PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33895270-0	2021	NLRP3 Inflammasome Inhibition by Histone Acetylation Ameliorates Sevoflurane-induced Cognitive Impairment in Aged Mice by Activating the Autophagy Pathway.	Sevoflurane	65-76	NLR family, pyrin domain containing 3	Mus musculus	0-5
33895270-7	2021	Concomitantly, sevoflurane upregulated components of the NLRP3 inflammasome (NLRP3, cleaved caspase-1, and IL-1beta) by promoting autophagic degradation in the aging brain.	Sevoflurane	15-26	NLR family, pyrin domain containing 3	Mus musculus	57-62
33895270-7	2021	Concomitantly, sevoflurane upregulated components of the NLRP3 inflammasome (NLRP3, cleaved caspase-1, and IL-1beta) by promoting autophagic degradation in the aging brain.	Sevoflurane	15-26	NLR family, pyrin domain containing 3	Mus musculus	77-82
33895270-9	2021	Treatment with 3-MA, an autophagy inhibitor, eliminated the neuroprotective effects of SAHA on improving cognition in mice, activating autophagy and downregulating the NLRP3 inflammasome.	3-methyladenine	15-19	NLR family, pyrin domain containing 3	Mus musculus	168-173
33895270-10	2021	Based on these results, histone acetylation activates autophagy plays an important role in inhibiting the activation of the NLRP3 inflammasome to protect the host from excessive neuroinflammation and sevoflurane-induced cognitive dysfunction in the aging brain.	Sevoflurane	200-211	NLR family, pyrin domain containing 3	Mus musculus	124-129
34036389-0	2021	kappa-opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice.	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer	31-38	NLR family, pyrin domain containing 3	Mus musculus	68-73
33753146-7	2021	Consistent with the results from molecular docking showing paeoniflorin antagonizes TLR4, NF-kappaB and NLRP3, the biochemical analysis also indicated paeoniflorin inhibited TLR4/NF-kappaB/NLRP3 signaling, decreased proinflammatory cytokine levels and microglial activation in the hippocampus of LPS induced mice.	peoniflorin	59-71	NLR family, pyrin domain containing 3	Mus musculus	104-109
34030116-3	2021	The present study tested whether exosome secretion from podocytes is enhanced by NADPH oxidase-produced reactive oxygen species (ROS), which may serve as a pathogenic mechanism mediating the release of inflammatory cytokines produced by the NLRP3 inflammasome in podocytes after Hcy stimulation.	Reactive Oxygen Species	104-127	NLR family, pyrin domain containing 3	Mus musculus	241-246
34030116-3	2021	The present study tested whether exosome secretion from podocytes is enhanced by NADPH oxidase-produced reactive oxygen species (ROS), which may serve as a pathogenic mechanism mediating the release of inflammatory cytokines produced by the NLRP3 inflammasome in podocytes after Hcy stimulation.	Reactive Oxygen Species	129-132	NLR family, pyrin domain containing 3	Mus musculus	241-246
34030116-3	2021	The present study tested whether exosome secretion from podocytes is enhanced by NADPH oxidase-produced reactive oxygen species (ROS), which may serve as a pathogenic mechanism mediating the release of inflammatory cytokines produced by the NLRP3 inflammasome in podocytes after Hcy stimulation.	Homocysteine	279-282	NLR family, pyrin domain containing 3	Mus musculus	241-246
34013370-0	2021	Hydrogen sulfide attenuates renal I/R-induced activation of the inflammatory response and apoptosis via regulating Nrf2-mediated NLRP3 signaling pathway inhibition.	Hydrogen Sulfide	0-16	NLR family, pyrin domain containing 3	Mus musculus	129-134
34013370-5	2021	The present study investigated whether Nrf2 and NLRP3 pathway participate in hydrogen sulfide-regulated renal I/R-induced activation of the inflammatory response and apoptosis.	Hydrogen Sulfide	77-93	NLR family, pyrin domain containing 3	Mus musculus	48-53
34013370-11	2021	Sodium hydrosulfide (NaHS) not only alleviated upregulation of NLRP3 protein expression levels, but also relieved renal injury, release of cytokines and cell apoptosis induced by renal I/R in wild-type mice, but not in Nrf2-KO mice.	sodium bisulfide	0-19	NLR family, pyrin domain containing 3	Mus musculus	63-68
34013370-11	2021	Sodium hydrosulfide (NaHS) not only alleviated upregulation of NLRP3 protein expression levels, but also relieved renal injury, release of cytokines and cell apoptosis induced by renal I/R in wild-type mice, but not in Nrf2-KO mice.	sodium bisulfide	21-25	NLR family, pyrin domain containing 3	Mus musculus	63-68
34030116-5	2021	In addition, Hcy induced activation in podocytes of NLRP3 inflammasomes and the formation of multivesicular bodies (MVBs) containing inflammatory cytokines, which were prevented by treatment with gp91 ds-tat or the ROS scavenger, catalase.	Homocysteine	13-16	NLR family, pyrin domain containing 3	Mus musculus	52-57
34013370-12	2021	NaHS alleviated NLRP3 inflammasome activation, renal injury, the inflammatory response and cell apoptosis via the Nrf2 signaling pathway in renal I/R model mice.	sodium bisulfide	0-4	NLR family, pyrin domain containing 3	Mus musculus	16-21
33753146-7	2021	Consistent with the results from molecular docking showing paeoniflorin antagonizes TLR4, NF-kappaB and NLRP3, the biochemical analysis also indicated paeoniflorin inhibited TLR4/NF-kappaB/NLRP3 signaling, decreased proinflammatory cytokine levels and microglial activation in the hippocampus of LPS induced mice.	peoniflorin	151-163	NLR family, pyrin domain containing 3	Mus musculus	104-109
34030116-5	2021	In addition, Hcy induced activation in podocytes of NLRP3 inflammasomes and the formation of multivesicular bodies (MVBs) containing inflammatory cytokines, which were prevented by treatment with gp91 ds-tat or the ROS scavenger, catalase.	ds-tat	201-207	NLR family, pyrin domain containing 3	Mus musculus	52-57
33753146-7	2021	Consistent with the results from molecular docking showing paeoniflorin antagonizes TLR4, NF-kappaB and NLRP3, the biochemical analysis also indicated paeoniflorin inhibited TLR4/NF-kappaB/NLRP3 signaling, decreased proinflammatory cytokine levels and microglial activation in the hippocampus of LPS induced mice.	peoniflorin	151-163	NLR family, pyrin domain containing 3	Mus musculus	189-194
34030116-5	2021	In addition, Hcy induced activation in podocytes of NLRP3 inflammasomes and the formation of multivesicular bodies (MVBs) containing inflammatory cytokines, which were prevented by treatment with gp91 ds-tat or the ROS scavenger, catalase.	Reactive Oxygen Species	215-218	NLR family, pyrin domain containing 3	Mus musculus	52-57
32989235-9	2021	In HFD-induced diabetic mouse model, administration of Pri (100 mug  kg-1  d-1, ip, for 6 weeks) reversed HFD-induced metabolic disorders via suppression of NLRP3 inflammasome activation.	pristimerin	55-58	NLR family, pyrin domain containing 3	Mus musculus	157-162
33872746-9	2021	FHL1 gene knockout (KO) or CS exposure during pregnancy each activated the expression of P2RX7, cell pyroptosis-related proteins (NLRP3, ASC, cleaved-caspase 1, IL-1beta), a muscle injury marker (MYOD1), and cytoskeletal proteins (MYBPC2, LDB3); these two factors had an additive effect.	Cesium	27-29	NLR family, pyrin domain containing 3	Mus musculus	130-135
32989235-0	2021	Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation.	pristimerin	0-11	NLR family, pyrin domain containing 3	Mus musculus	95-100
32989235-10	2021	Taken together, our results demonstrate that Pri acts as a NLRP3 inhibitor, suggesting that Pri might be useful for the treatment of NLRP3-associated diseases.	pristimerin	45-48	NLR family, pyrin domain containing 3	Mus musculus	59-64
32989235-4	2021	In this study we investigated whether NLRP3 inflammasome was associated with the anti-inflammatory activity of Pri.	pristimerin	111-114	NLR family, pyrin domain containing 3	Mus musculus	38-43
32989235-10	2021	Taken together, our results demonstrate that Pri acts as a NLRP3 inhibitor, suggesting that Pri might be useful for the treatment of NLRP3-associated diseases.	pristimerin	45-48	NLR family, pyrin domain containing 3	Mus musculus	133-138
32989235-6	2021	Pri specifically inhibited NLRP3 inflammasome activation, had no visible effects on NLRC4 and AIM2 inflammasome activation.	pristimerin	0-3	NLR family, pyrin domain containing 3	Mus musculus	27-32
32989235-7	2021	Furthermore, we demonstrated that Pri blocked the assembly of the NLRP3 inflammasome via disturbing the interaction between NEK7 and NLRP3; the alpha, beta-unsaturated carbonyl moiety of Pri was essential for NLRP3 inflammasome inactivation.	pristimerin	34-37	NLR family, pyrin domain containing 3	Mus musculus	66-71
32989235-7	2021	Furthermore, we demonstrated that Pri blocked the assembly of the NLRP3 inflammasome via disturbing the interaction between NEK7 and NLRP3; the alpha, beta-unsaturated carbonyl moiety of Pri was essential for NLRP3 inflammasome inactivation.	pristimerin	34-37	NLR family, pyrin domain containing 3	Mus musculus	133-138
32989235-7	2021	Furthermore, we demonstrated that Pri blocked the assembly of the NLRP3 inflammasome via disturbing the interaction between NEK7 and NLRP3; the alpha, beta-unsaturated carbonyl moiety of Pri was essential for NLRP3 inflammasome inactivation.	pristimerin	34-37	NLR family, pyrin domain containing 3	Mus musculus	133-138
32989235-8	2021	In LPS-induced systemic inflammation mouse model and MSU-induced mouse peritonitis model, preinjection of Pri (500 mug/kg, ip) produced remarkable therapeutic effects via inhibition of NLRP3 inflammasome in vivo.	pristimerin	106-109	NLR family, pyrin domain containing 3	Mus musculus	185-190
32989235-10	2021	Taken together, our results demonstrate that Pri acts as a NLRP3 inhibitor, suggesting that Pri might be useful for the treatment of NLRP3-associated diseases.	pristimerin	92-95	NLR family, pyrin domain containing 3	Mus musculus	59-64
32989235-10	2021	Taken together, our results demonstrate that Pri acts as a NLRP3 inhibitor, suggesting that Pri might be useful for the treatment of NLRP3-associated diseases.	pristimerin	92-95	NLR family, pyrin domain containing 3	Mus musculus	133-138
32803914-11	2021	Moreover, NLRP3 knockdown in macrophage restricted the conditioned ADEs to promote macrophage towards to Ti-induced M1-type polarization.	Titanium	105-107	NLR family, pyrin domain containing 3	Mus musculus	10-15
33872571-8	2021	Treatment with mito-TEMPO significantly reduced the increased production of pro-inflammatory cytokines and activations of TLR9/NF-kappaB and NLRP3/caspase-1 inflammasome induced by RXRbeta knockdown in ox-LDL treated HAECs.	MitoTEMPO	15-25	NLR family, pyrin domain containing 3	Mus musculus	141-146
33398541-0	2021	Amelioration of Juglanin against LPS-Induced Activation of NLRP3 Inflammasome in Chondrocytes Mediated by SIRT1.	juglanin	16-24	NLR family, pyrin domain containing 3	Mus musculus	59-64
33398541-9	2021	Juglanin inhibited the activation of the TxNIP/NLRP3/ASC/caspase-1 axis, and decreased production of IL-1beta and IL-18.	juglanin	0-8	NLR family, pyrin domain containing 3	Mus musculus	47-52
33398541-11	2021	SIRT1 silencing abolished the anti-NLRP3 inflammasome effect of juglanin, indicating that the effects of juglanin are dependent on its amelioration on SIRT1 expression.	juglanin	64-72	NLR family, pyrin domain containing 3	Mus musculus	35-40
33452697-10	2021	PSSM1443 functions as an inhibitor of the TXNIP-NLRP3 complex and its administration can decrease inflammation in SIMD-mice.	pssm1443	0-8	NLR family, pyrin domain containing 3	Mus musculus	48-53
33832341-9	2021	In an acute model of myocardial injury, perfusion of isolated mouse hearts with empagliflozin or tetrodotoxin prevented activation of the cardiac NLRP3 inflammasome and improved functional recovery after ischemia.	empagliflozin	80-93	NLR family, pyrin domain containing 3	Mus musculus	146-151
33832341-9	2021	In an acute model of myocardial injury, perfusion of isolated mouse hearts with empagliflozin or tetrodotoxin prevented activation of the cardiac NLRP3 inflammasome and improved functional recovery after ischemia.	Tetrodotoxin	97-109	NLR family, pyrin domain containing 3	Mus musculus	146-151
33744777-0	2021	Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation.	loganin	0-7	NLR family, pyrin domain containing 3	Mus musculus	105-110
33744777-8	2021	Besides, loganin dramatically inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1beta secretion.	loganin	9-16	NLR family, pyrin domain containing 3	Mus musculus	40-45
33744777-9	2021	Further in vitro studies confirmed that loganin efficiently inhibited M1 macrophage polarization and NLRP3 inflammasome activation by blocking the extra-cellular signal-regulated kinase (ERK) and nuclear factor-kappa B (NF-kappaB) pathways.	loganin	40-47	NLR family, pyrin domain containing 3	Mus musculus	101-106
33744777-10	2021	Taken together, the anti-inflammatory effect of loganin in sepsis-induced ALI was associated with the ERK and NF-kappaB pathway-mediated macrophage polarization and NLRP3 inflammasome activation.	loganin	48-55	NLR family, pyrin domain containing 3	Mus musculus	165-170
33705947-6	2021	We also demonstrated that luteolin inhibited NLRP3 inflammasome-derived caspase-1 activation and IL-1beta secretion in J774A.1 macrophages upon diverse stimuli including ATP, nigericin, or silica crystals.	Nigericin	175-184	NLR family, pyrin domain containing 3	Mus musculus	45-50
33452697-0	2021	Targeting the TXNIP-NLRP3 interaction with PSSM1443 to suppress inflammation in sepsis-induced myocardial dysfunction.	pssm1443	43-51	NLR family, pyrin domain containing 3	Mus musculus	20-25
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	103-108
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	183-188
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	Histidine	99-102	NLR family, pyrin domain containing 3	Mus musculus	183-188
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	pssm1443	145-153	NLR family, pyrin domain containing 3	Mus musculus	103-108
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	pssm1443	145-153	NLR family, pyrin domain containing 3	Mus musculus	183-188
33452697-7	2021	Furthermore, using an amplified luminescent proximity homogeneous assay (Alpha) with GST-TXNIP and His-NLRP3, we obtained a small molecule named PSSM1443 that could disrupt the TXNIP-NLRP3 interaction in vitro, impairing NLRP3 downstream events.	pssm1443	145-153	NLR family, pyrin domain containing 3	Mus musculus	183-188
33705947-6	2021	We also demonstrated that luteolin inhibited NLRP3 inflammasome-derived caspase-1 activation and IL-1beta secretion in J774A.1 macrophages upon diverse stimuli including ATP, nigericin, or silica crystals.	Silicon Dioxide	189-195	NLR family, pyrin domain containing 3	Mus musculus	45-50
34037304-1	2021	Glyburide (Gly) could inhibit NLRP3 inflammasome, as well as could be treated with Type 2 diabetes as a common medication.	Glyburide	0-9	NLR family, pyrin domain containing 3	Mus musculus	30-35
33716060-11	2021	Furthermore, TMP intervention participated in the inhibition of NLRP3 inflammasome accompanied with pyroptosis, as well as upregulating Trx expression and downregulating p-NF-kappaB, while the protective effect of TMP was limited to the involvement of Txnip overexpression.	Thymidine Monophosphate	13-16	NLR family, pyrin domain containing 3	Mus musculus	64-69
34052309-0	2021	Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson"s disease model.	Glyburide	36-49	NLR family, pyrin domain containing 3	Mus musculus	14-19
34052309-0	2021	Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson"s disease model.	Paraquat	114-122	NLR family, pyrin domain containing 3	Mus musculus	14-19
32814473-0	2021	Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-kappaB signaling.	irisin	0-6	NLR family, pyrin domain containing 3	Mus musculus	82-87
32814473-8	2021	Increased activity of NLRP3 inflammasome was discovered in LPS-challenged Raw264.7 cells, along with elevated levels of inflammation and apoptosis, the effects of which were mediated by activation of ROS and nuclear factor kappaB (NF-kappaB) signaling.	Reactive Oxygen Species	200-203	NLR family, pyrin domain containing 3	Mus musculus	22-27
32814473-10	2021	Our study demonstrated that irisin countered LPS-mediated liver injury via inhibiting apoptosis, NLRP3 inflammasome activation and NF-kappaB signaling.	irisin	28-34	NLR family, pyrin domain containing 3	Mus musculus	97-102
34047943-6	2021	Melatonin was found to reduce both paw thickness and the inflammation index in the mouse model, and melatonin also reduced the mRNA levels of interleukin-1 beta (IL-1beta), IL-6 and NLR family pyrin domain containing 3 (NLRP3) inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	220-225
34047943-6	2021	Melatonin was found to reduce both paw thickness and the inflammation index in the mouse model, and melatonin also reduced the mRNA levels of interleukin-1 beta (IL-1beta), IL-6 and NLR family pyrin domain containing 3 (NLRP3) inflammasome.	Melatonin	100-109	NLR family, pyrin domain containing 3	Mus musculus	182-218
34047943-6	2021	Melatonin was found to reduce both paw thickness and the inflammation index in the mouse model, and melatonin also reduced the mRNA levels of interleukin-1 beta (IL-1beta), IL-6 and NLR family pyrin domain containing 3 (NLRP3) inflammasome.	Melatonin	100-109	NLR family, pyrin domain containing 3	Mus musculus	220-225
34047943-10	2021	Western blot analysis showed that the expression of NLRP3, caspase-1 and pro-IL-1beta was also inhibited by melatonin.	Melatonin	108-117	NLR family, pyrin domain containing 3	Mus musculus	52-57
34047943-11	2021	In conclusion, our study demonstrated that melatonin alleviated gouty inflammation in vivo and in vitro, and the underlying mechanism may involve inhibiting the assembly of the NLRP3 inflammasome.	Melatonin	43-52	NLR family, pyrin domain containing 3	Mus musculus	177-182
34052309-9	2021	Overall, our findings demonstrated that glibenclamide protected dopaminergic neurons in a mouse PD model induced by combined exposures of paraquat and maneb through suppression of NLRP3 inflammasome activation, microglial M1 polarization and oxidative stress.	Glyburide	40-53	NLR family, pyrin domain containing 3	Mus musculus	180-185
34052309-0	2021	Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson"s disease model.	Maneb	127-132	NLR family, pyrin domain containing 3	Mus musculus	14-19
34052309-4	2021	This study was designed to investigate whether glibenclamide, an inhibitor of NLRP3 inflammasome, could offer a reliable protective strategy for PD in a mouse PD model induced by paraquat and maneb.	Glyburide	47-60	NLR family, pyrin domain containing 3	Mus musculus	78-83
34037304-1	2021	Glyburide (Gly) could inhibit NLRP3 inflammasome, as well as could be treated with Type 2 diabetes as a common medication.	Glyburide	0-3	NLR family, pyrin domain containing 3	Mus musculus	30-35
34037304-10	2021	Results suggested glyburide might inhibit NLRP3 inflammasome to attenuate inflammation-related lung tumorigenesis caused by intratracheal instillation of B(a)p/LPS in non-diabetes mice.	Glyburide	18-27	NLR family, pyrin domain containing 3	Mus musculus	42-47
34031983-0	2021	Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.	Verapamil	0-9	NLR family, pyrin domain containing 3	Mus musculus	69-74
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	17-30	NLR family, pyrin domain containing 3	Mus musculus	49-54
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	17-30	NLR family, pyrin domain containing 3	Mus musculus	115-120
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	174-187	NLR family, pyrin domain containing 3	Mus musculus	49-54
34052309-6	2021	Mechanistically, glibenclamide treatment blocked NLRP3 inflammasome activation evidenced by reduced expressions of NLRP3, activated caspase-1 and mature interleukin-1beta in glibenclamide co-treated mice compared with those in paraquat and maneb group mice.	Glyburide	174-187	NLR family, pyrin domain containing 3	Mus musculus	115-120
34052623-0	2021	ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus.	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	28-33
34031983-6	2021	Subsequently, overexpression of NLRP3 in mouse liver was induced by transfection with AAV-NRLP3 in vivo and in vitro to identity whether verapamil inhibited early ALF through suppressing the activation of NLRP3 inflammasome.	Verapamil	137-146	NLR family, pyrin domain containing 3	Mus musculus	32-37
34031983-7	2021	We found that ALF was induced by LPS/GalN in mice but was alleviated by verapamil through a mechanism that correlated with suppression of the NLRP3 inflammasome pathway.	Verapamil	72-81	NLR family, pyrin domain containing 3	Mus musculus	142-147
34031983-9	2021	Overexpression of NLRP3 via AAV in mouse liver in vivo and in vitro reduced the therapeutic effect of verapamil on LPS/GalN-induced ALF.	Verapamil	102-111	NLR family, pyrin domain containing 3	Mus musculus	18-23
34031983-9	2021	Overexpression of NLRP3 via AAV in mouse liver in vivo and in vitro reduced the therapeutic effect of verapamil on LPS/GalN-induced ALF.	Galactosamine	119-123	NLR family, pyrin domain containing 3	Mus musculus	18-23
34031983-10	2021	Taken together, the TXNIP antagonist verapamil could inhibit activation of the NLRP3 inflammasome, inflammatory responses and oxidative stress to alleviate LPS/GalN-induced ALF.	Verapamil	37-46	NLR family, pyrin domain containing 3	Mus musculus	79-84
34018696-4	2021	The GIT (stomach, colon, cecum and feces) microbiota was analyzed by 16S rDNA sequencing and the short chain fatty acids were detected using GC-MS. Dietary administration of AJOP significantly alleviated hyperuricemia, regulated uric acid metabolism, inhibited the activation of the NLRP3 inflammasome and NF-kappaB-related signaling pathway, and restored m6A methylation levels.	ajop	174-178	NLR family, pyrin domain containing 3	Mus musculus	283-288
34058500-6	2021	Mice daily drinking soluble La(III) species to mimic drinking tea process for 90 days were found to present NLRP3 inflammasome activation in liver and kidney, as a result of chronic fibrosis, which is potentially correlated to insoluble La(III) species formation.	la(iii)	28-35	NLR family, pyrin domain containing 3	Mus musculus	108-113
34018522-0	2021	Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation.	epigallocatechin gallate	0-26	NLR family, pyrin domain containing 3	Mus musculus	138-143
34018522-0	2021	Epigallocatechin-3-gallate attenuates acute pancreatitis induced lung injury by targeting mitochondrial reactive oxygen species triggered NLRP3 inflammasome activation.	Oxygen	113-119	NLR family, pyrin domain containing 3	Mus musculus	138-143
34018522-5	2021	Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung.	epigallocatechin gallate	10-14	NLR family, pyrin domain containing 3	Mus musculus	85-112
34018522-5	2021	Moreover, EGCG substantially attenuated oxidative stress and concurrently suppressed NOD-like receptor protein 3 (NLRP3) inflammasome activation in the lung.	epigallocatechin gallate	10-14	NLR family, pyrin domain containing 3	Mus musculus	114-119
34018522-7	2021	Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation.	epigallocatechin gallate	95-99	NLR family, pyrin domain containing 3	Mus musculus	43-48
34018522-7	2021	Meanwhile, the amount of ox-mtDNA bound to NLRP3 decreased significantly by the treatment with EGCG, resulting in impaired NLRP3 inflammasome activation.	epigallocatechin gallate	95-99	NLR family, pyrin domain containing 3	Mus musculus	123-128
34018522-8	2021	In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO.	epigallocatechin gallate	50-54	NLR family, pyrin domain containing 3	Mus musculus	31-36
34018522-8	2021	In addition, the antagonism of NLRP3 signaling by EGCG was affected in the presence of the mtROS stimulant rotenone or scavenger Mito-TEMPO.	Rotenone	107-115	NLR family, pyrin domain containing 3	Mus musculus	31-36
34018522-9	2021	Altogether, EGCG possesses potent activity to attenuate lung injury during AP progression by inhibiting NLRP3 inflammasome activation.	epigallocatechin gallate	12-16	NLR family, pyrin domain containing 3	Mus musculus	104-109
34018522-10	2021	As for the mechanism, the EGCG-conferred restriction of NLRP3 inflammasome activation probably arises from the elimination of mtROS as well as its oxidative product ox-mtDNA, which consequently enables the protection against AP-associated lung injury.	epigallocatechin gallate	26-30	NLR family, pyrin domain containing 3	Mus musculus	56-61
34003868-9	2021	These murine model results indicate that young female mice are more predisposed to metal-DTH augmented inflammatory responses to wear debris, which is highly influenced by active NLRP3 inflammasome/caspase-1 danger signaling.	Metals	83-88	NLR family, pyrin domain containing 3	Mus musculus	179-184
34000757-9	2021	HFD NLRP3-/- mice developed lower increase in body and epididymal fat weight, cholesterol levels and systemic and bowel inflammation.	Cholesterol	78-89	NLR family, pyrin domain containing 3	Mus musculus	4-9
34044073-13	2021	In summary, baicalin and baicalein are promising drug candidates for the treatment of HN by inhibiting XO activity, reducing inflammation and cell apoptosis through down-regulating TLRs/NLRP3/NF-kappaB, MAPK, PI3K/AKT/NF-kappaB pathways.	baicalin	12-20	NLR family, pyrin domain containing 3	Mus musculus	186-191
34044073-13	2021	In summary, baicalin and baicalein are promising drug candidates for the treatment of HN by inhibiting XO activity, reducing inflammation and cell apoptosis through down-regulating TLRs/NLRP3/NF-kappaB, MAPK, PI3K/AKT/NF-kappaB pathways.	baicalein	25-34	NLR family, pyrin domain containing 3	Mus musculus	186-191
34029695-8	2021	Further, TXNIP inhibition with verapamil replicated TXNIP/NLRP3-inflammasome downregulation in aged animals, with FOXO-1 and mTOR upregulation.	Verapamil	31-40	NLR family, pyrin domain containing 3	Mus musculus	58-63
34019860-0	2021	Safranal inhibits NLRP3 inflammasome activation by preventing ASC oligomerization.	safranal	0-8	NLR family, pyrin domain containing 3	Mus musculus	18-23
34019860-6	2021	We identified safranal, a small molecule responsible for the essence of saffron as a potential inhibitor of the NLRP3 inflammasome.	safranal	14-22	NLR family, pyrin domain containing 3	Mus musculus	112-117
34019860-8	2021	Safranal markedly suppressed the expression of NLRP3 and its ATPase activity.	safranal	0-8	NLR family, pyrin domain containing 3	Mus musculus	47-52
34019860-9	2021	Safranal treatment enhanced the expression of NRF2, whereas, si-RNA mediated silencing of Nrf2 abrogated the anti-NLRP3 effect of safranal.	safranal	130-138	NLR family, pyrin domain containing 3	Mus musculus	114-119
34019860-11	2021	Safranal also displayed anti-NLRP3 activity in multiple mice models.	safranal	0-8	NLR family, pyrin domain containing 3	Mus musculus	29-34
34019860-13	2021	Thus, our data projects safranal as a potential preclinical drug candidate against NLRP3 inflammasome triggered chronic inflammation.	safranal	24-32	NLR family, pyrin domain containing 3	Mus musculus	83-88
34010608-8	2021	Inhibiting autophagy with 3-MA reversed the inhibition of NLRP3 inflammasome activation and diminished the neuroprotective effects of Gas6.	3-methyladenine	26-30	NLR family, pyrin domain containing 3	Mus musculus	58-63
34055976-0	2021	PCB118 Induces Inflammation of Islet Beta Cells via Activating ROS-NLRP3 Inflammasome Signaling.	2,3',4,4',5-pentachlorobiphenyl	0-6	NLR family, pyrin domain containing 3	Mus musculus	67-72
34055976-0	2021	PCB118 Induces Inflammation of Islet Beta Cells via Activating ROS-NLRP3 Inflammasome Signaling.	ros	63-66	NLR family, pyrin domain containing 3	Mus musculus	67-72
34055976-4	2021	In this study, we explored whether ROS-induced NLRP3 inflammasome priming and activation were related to PCB118 exposure in mouse islet beta-TC-6 cells and the mechanisms of diabetes.	ros	35-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
34055976-4	2021	In this study, we explored whether ROS-induced NLRP3 inflammasome priming and activation were related to PCB118 exposure in mouse islet beta-TC-6 cells and the mechanisms of diabetes.	2,3',4,4',5-pentachlorobiphenyl	105-111	NLR family, pyrin domain containing 3	Mus musculus	47-52
34055976-8	2021	Conclusions: PCB118 can activate NLRP3 inflammasome signaling in islet beta cells via the oxidative stress pathway and cause inflammation in islet beta cells.	2,3',4,4',5-pentachlorobiphenyl	13-19	NLR family, pyrin domain containing 3	Mus musculus	33-38
33714750-6	2021	NLRP3 expression in the nigrostriatal system of MPTP-induced mice was significantly increased compared to control, whereas NLRP1, NLRP2, NLRC4, and AIM2 expression in the nigrostriatal system, as well as NLRP3 expression in the cerebral cortex and hippocampus, were similar in the two groups.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	48-52	NLR family, pyrin domain containing 3	Mus musculus	0-5
33893171-6	2021	Through mass spectrum and biochemical analysis, we identified lysine 565 and lysine 687 as theK63-linked polyubiquitination sites of NLRP3.	Lysine	62-68	NLR family, pyrin domain containing 3	Mus musculus	133-138
33714750-7	2021	Furthermore, MPTP-induced mice exhibited behavioral dysfunctions, dopaminergic neuronal degeneration, and activation of glial cells and the NLRP3 inflammasome.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	NLR family, pyrin domain containing 3	Mus musculus	140-145
33893171-6	2021	Through mass spectrum and biochemical analysis, we identified lysine 565 and lysine 687 as theK63-linked polyubiquitination sites of NLRP3.	Lysine	77-83	NLR family, pyrin domain containing 3	Mus musculus	133-138
33714750-8	2021	MCC950 treatment of MPTP-induced mice improved behavioral dysfunctions, reduced dopaminergic neuronal degeneration, and inhibited the activation of glial cells and the NLRP3 inflammasome.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	20-24	NLR family, pyrin domain containing 3	Mus musculus	168-173
33714750-9	2021	In conclusion, these findings indicated that NLRP3, not NLRP1, NLRP2, NLRC4, and AIM2, may be the key inflammasome that promotes MPTP-induced pathogenesis.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	129-133	NLR family, pyrin domain containing 3	Mus musculus	45-50
33992835-9	2021	Moreover, application of A-68930 to activate DRD1 reduced cardiac injury and fibrosis in a DOX-treated mouse model by suppressing the NLRP3 inflammasome in the heart.	A 68930	25-32	NLR family, pyrin domain containing 3	Mus musculus	134-139
33992835-9	2021	Moreover, application of A-68930 to activate DRD1 reduced cardiac injury and fibrosis in a DOX-treated mouse model by suppressing the NLRP3 inflammasome in the heart.	Doxorubicin	91-94	NLR family, pyrin domain containing 3	Mus musculus	134-139
33992835-10	2021	These findings indicate that DRD1 signaling may protect against DOX-induced cardiac injury by inhibiting the NLRP3 inflammasome-mediated inflammation.	Doxorubicin	64-67	NLR family, pyrin domain containing 3	Mus musculus	109-114
34045963-11	2021	In addition, zerumbone suppressed the production of IL-1beta and inhibited the activity of NLRP3 inflammasome in LPS/ATP- and LPS/nigericin-activated J774A.1 cells.	Adenosine Triphosphate	117-120	NLR family, pyrin domain containing 3	Mus musculus	91-96
34007200-0	2021	microRNA-223 Deficiency Exacerbates Acute Inflammatory Response to Monosodium Urate Crystals by Targeting NLRP3.	Uric Acid	67-83	NLR family, pyrin domain containing 3	Mus musculus	106-111
33974808-0	2021	Saikosaponin-d protects against liver fibrosis by regulating Estrogen receptor-beta/NLRP3 inflammasome pathway.	saikosaponin D	0-14	NLR family, pyrin domain containing 3	Mus musculus	84-89
34045963-11	2021	In addition, zerumbone suppressed the production of IL-1beta and inhibited the activity of NLRP3 inflammasome in LPS/ATP- and LPS/nigericin-activated J774A.1 cells.	Nigericin	130-139	NLR family, pyrin domain containing 3	Mus musculus	91-96
34045963-0	2021	Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages.	zerumbone	0-9	NLR family, pyrin domain containing 3	Mus musculus	91-96
34045963-13	2021	In conclusion, our experimental results demonstrate that zerumbone effectively attenuates the LPS-induced inflammatory response in macrophages both in vitro and ex vivo by suppressing the activation of the ERK-MAPK and NF-kappaB signaling pathways as well as blocking the activation of the NLRP3 inflammasome.	zerumbone	57-66	NLR family, pyrin domain containing 3	Mus musculus	290-295
34045963-2	2021	However, the effects of zerumbone on activation of the NLRP3 inflammasome in macrophages have not been examined.	zerumbone	24-33	NLR family, pyrin domain containing 3	Mus musculus	55-60
33984334-0	2021	A new mechanism of obeticholic acid on NASH treatment by inhibiting NLRP3 inflammasome activation in macrophage.	obeticholic acid	19-35	NLR family, pyrin domain containing 3	Mus musculus	68-73
34045963-11	2021	In addition, zerumbone suppressed the production of IL-1beta and inhibited the activity of NLRP3 inflammasome in LPS/ATP- and LPS/nigericin-activated J774A.1 cells.	zerumbone	13-22	NLR family, pyrin domain containing 3	Mus musculus	91-96
33460751-0	2021	Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-kappaB signaling and NLRP3 inflammasome activation.	suhuang	89-96	NLR family, pyrin domain containing 3	Mus musculus	189-194
33460751-15	2021	Suhuang also limited NLRP3 inflammasome activation by blocking NLRP3-ASC interaction and promoting NLRP3 ubiquitination degradation.	suhuang	0-7	NLR family, pyrin domain containing 3	Mus musculus	21-26
33460751-15	2021	Suhuang also limited NLRP3 inflammasome activation by blocking NLRP3-ASC interaction and promoting NLRP3 ubiquitination degradation.	suhuang	0-7	NLR family, pyrin domain containing 3	Mus musculus	63-68
33460751-15	2021	Suhuang also limited NLRP3 inflammasome activation by blocking NLRP3-ASC interaction and promoting NLRP3 ubiquitination degradation.	suhuang	0-7	NLR family, pyrin domain containing 3	Mus musculus	63-68
33460751-19	2021	CONCLUSIONS: Altogether, our work reveals that Suhuang inhibits non-resolving inflammation through inhibition of NF-kappaB signaling and NLRP3 inflammasome activation by preserving mitochondrial homeostasis, providing new pharmacological data for the clinical use of Suhuang.	suhuang	47-54	NLR family, pyrin domain containing 3	Mus musculus	137-142
34025639-10	2021	Since uric acid is a ligand of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, TFGU was further validated to inhibit the activation of NLRP3 inflammasome by CPT-11.	Uric Acid	6-15	NLR family, pyrin domain containing 3	Mus musculus	87-92
34024736-0	2021	Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3beta/AMPK/NLRP3 inflammasome pathway.	fisetin	0-7	NLR family, pyrin domain containing 3	Mus musculus	82-87
34024736-13	2021	The anti-inflammatory effects of fisetin were partially inhibited by the AMPK specific inhibitor compound C. CONCLUSIONS: Fisetin showed protective effects against hepatic IRI, countering inflammatory responses through mediating the GSK3beta/AMPK/NLRP3 inflammasome pathway.	fisetin	33-40	NLR family, pyrin domain containing 3	Mus musculus	247-252
34024736-13	2021	The anti-inflammatory effects of fisetin were partially inhibited by the AMPK specific inhibitor compound C. CONCLUSIONS: Fisetin showed protective effects against hepatic IRI, countering inflammatory responses through mediating the GSK3beta/AMPK/NLRP3 inflammasome pathway.	fisetin	122-129	NLR family, pyrin domain containing 3	Mus musculus	247-252
33975771-0	2021	Thalidomide reduces glycerol-induced acute kidney injury by inhibition of NF-kappaB, NLRP3 inflammasome, COX-2 and inflammatory cytokines.	Thalidomide	0-11	NLR family, pyrin domain containing 3	Mus musculus	85-90
33975771-0	2021	Thalidomide reduces glycerol-induced acute kidney injury by inhibition of NF-kappaB, NLRP3 inflammasome, COX-2 and inflammatory cytokines.	Glycerol	20-28	NLR family, pyrin domain containing 3	Mus musculus	85-90
34025639-10	2021	Since uric acid is a ligand of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, TFGU was further validated to inhibit the activation of NLRP3 inflammasome by CPT-11.	Uric Acid	6-15	NLR family, pyrin domain containing 3	Mus musculus	164-169
34025639-10	2021	Since uric acid is a ligand of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, TFGU was further validated to inhibit the activation of NLRP3 inflammasome by CPT-11.	Irinotecan	186-192	NLR family, pyrin domain containing 3	Mus musculus	164-169
32176932-8	2021	RESULTS: The results demonstrated that the effect of HFD on inflammatory cytokines in mice with apoE-/- background was reversed by celastrol administration, and celastrol treatment inhibited the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1/interleukin-1beta signaling cascades in peripheral blood mononuclear cells from HFD-fed apoE-/- mice.	celastrol	161-170	NLR family, pyrin domain containing 3	Mus musculus	248-253
34017331-0	2021	ATP Facilitates Staphylococcal Enterotoxin O Induced Neutrophil IL-1beta Secretion via NLRP3 Inflammasome Dependent Pathways.	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	87-92
33911050-0	2021	Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS.	Papaverine	0-10	NLR family, pyrin domain containing 3	Mus musculus	55-60
33911050-6	2021	In addition, MPTP/LPS enhanced interleukin-1beta (IL-1beta) expression and processing via nod-like receptor protein 3 (NLRP3) inflammasome activation in the SN region of mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	NLR family, pyrin domain containing 3	Mus musculus	90-117
33911050-6	2021	In addition, MPTP/LPS enhanced interleukin-1beta (IL-1beta) expression and processing via nod-like receptor protein 3 (NLRP3) inflammasome activation in the SN region of mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	13-17	NLR family, pyrin domain containing 3	Mus musculus	119-124
34017331-7	2021	However, SEO-induced IL-1beta secretion was abolished in the neutrophils of NLRP3-/- mice compared with those of wild type mice, indicating that activation of NLRP3 inflammasome mediated IL-1beta secretion during neutrophils stimulation with SEO under the action of ATP.	seo	9-12	NLR family, pyrin domain containing 3	Mus musculus	76-81
34017331-7	2021	However, SEO-induced IL-1beta secretion was abolished in the neutrophils of NLRP3-/- mice compared with those of wild type mice, indicating that activation of NLRP3 inflammasome mediated IL-1beta secretion during neutrophils stimulation with SEO under the action of ATP.	seo	9-12	NLR family, pyrin domain containing 3	Mus musculus	159-164
34017331-7	2021	However, SEO-induced IL-1beta secretion was abolished in the neutrophils of NLRP3-/- mice compared with those of wild type mice, indicating that activation of NLRP3 inflammasome mediated IL-1beta secretion during neutrophils stimulation with SEO under the action of ATP.	seo	242-245	NLR family, pyrin domain containing 3	Mus musculus	159-164
34017331-7	2021	However, SEO-induced IL-1beta secretion was abolished in the neutrophils of NLRP3-/- mice compared with those of wild type mice, indicating that activation of NLRP3 inflammasome mediated IL-1beta secretion during neutrophils stimulation with SEO under the action of ATP.	Adenosine Triphosphate	266-269	NLR family, pyrin domain containing 3	Mus musculus	159-164
33656514-0	2021	Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1beta release.	Vincristine	0-11	NLR family, pyrin domain containing 3	Mus musculus	65-70
33656514-3	2021	Here, we show that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and subsequent release of interleukin-1beta from macrophages, with mechanical allodynia and gait disturbances significantly reduced in knockout mice lacking NLRP3 signaling pathway components, or after treatment with the NLRP3 inhibitor MCC950.	Vincristine	19-30	NLR family, pyrin domain containing 3	Mus musculus	92-97
33656514-3	2021	Here, we show that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and subsequent release of interleukin-1beta from macrophages, with mechanical allodynia and gait disturbances significantly reduced in knockout mice lacking NLRP3 signaling pathway components, or after treatment with the NLRP3 inhibitor MCC950.	Vincristine	19-30	NLR family, pyrin domain containing 3	Mus musculus	268-273
33656514-3	2021	Here, we show that vincristine-induced peripheral neuropathy is driven by activation of the NLRP3 inflammasome and subsequent release of interleukin-1beta from macrophages, with mechanical allodynia and gait disturbances significantly reduced in knockout mice lacking NLRP3 signaling pathway components, or after treatment with the NLRP3 inhibitor MCC950.	Vincristine	19-30	NLR family, pyrin domain containing 3	Mus musculus	268-273
33556877-14	2021	The DOX + APG groups had much lower tissue MDA, IL-6, TNF-alpha, NLRP3, caspase-1, and IL-1beta levels and generation of intracellular ROS, but significantly higher SOD activity and GSH levels compared to those of the DOX group.	Doxorubicin	4-7	NLR family, pyrin domain containing 3	Mus musculus	65-70
33556877-14	2021	The DOX + APG groups had much lower tissue MDA, IL-6, TNF-alpha, NLRP3, caspase-1, and IL-1beta levels and generation of intracellular ROS, but significantly higher SOD activity and GSH levels compared to those of the DOX group.	Apigenin	10-13	NLR family, pyrin domain containing 3	Mus musculus	65-70
33319359-11	2021	Moreover, the expression of NLRP3 and phospho-NF-kappaB p65 in pancreatic and intestinal tissues was notably suppressed by 3,4-DAA.	N-(3',4'-dimethoxycinnamonyl)anthranilic acid	123-130	NLR family, pyrin domain containing 3	Mus musculus	28-33
33711331-0	2021	Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNAs alteration.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	22-27
33639565-9	2021	We observed that CA-074me not only inhibits CTSB, but also suppresses the expression and activity of NLRP3, ASC and caspase-1.	CA 074 methyl ester	17-25	NLR family, pyrin domain containing 3	Mus musculus	101-106
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	43-55	NLR family, pyrin domain containing 3	Mus musculus	99-104
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	57-60	NLR family, pyrin domain containing 3	Mus musculus	99-104
33995126-6	2021	In addition, the decreased AMPK phosphorylation and NLRP3 activation induced by high glucose (HG) in HK-2 cells could be alleviated by the overexpression of DsbA-L.	Glucose	85-92	NLR family, pyrin domain containing 3	Mus musculus	52-57
33417223-4	2021	We examined activation of the NLRP3 pathway in microglia exposed to cocaine, followed by validation in mice administered either cocaine or saline for 7 days, with or without pretreatment with the NLRP3 inhibitor, MCC950, and in postmortem cortical brain tissues of chronic cocaine-dependent humans.	Cocaine	68-75	NLR family, pyrin domain containing 3	Mus musculus	30-35
33827248-14	2021	CONCLUSIONS: Our results show that intracerebral heme injection induces neuroinflammation, and neurological deficits, in an NLRP3-dependent manner, suggesting that this is a feasible model to evaluate the role of heme in neurological disorders.	Heme	49-53	NLR family, pyrin domain containing 3	Mus musculus	124-129
33827248-14	2021	CONCLUSIONS: Our results show that intracerebral heme injection induces neuroinflammation, and neurological deficits, in an NLRP3-dependent manner, suggesting that this is a feasible model to evaluate the role of heme in neurological disorders.	Heme	213-217	NLR family, pyrin domain containing 3	Mus musculus	124-129
34047713-0	2021	NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice.	cucurbitacin B	29-43	NLR family, pyrin domain containing 3	Mus musculus	0-5
34047713-1	2021	Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages.	Uric Acid	66-82	NLR family, pyrin domain containing 3	Mus musculus	207-212
34047713-1	2021	Gouty arthritis is a common inflammatory disease characterized by monosodium urate (MSU) crystal induced nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome activation with up-regulated caspase-1 protease and IL-1beta in macrophages.	Uric Acid	84-87	NLR family, pyrin domain containing 3	Mus musculus	207-212
33959014-14	2021	Further mechanistic investigation showed that DHB distinctly down-regulated renal mRNA and protein levels of URAT1, GLUT9, NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), caspase-1 and IL-1beta.	dihydroberberine	46-49	NLR family, pyrin domain containing 3	Mus musculus	123-142
33931568-3	2021	Here, we show that thiolutin (THL), an inhibitor of the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease, blocks NLRP3 inflammasome activation by canonical, noncanonical, alternative, and transcription-independent pathways at nanomolar concentrations.	acetopyrrothine	19-28	NLR family, pyrin domain containing 3	Mus musculus	120-125
33931568-3	2021	Here, we show that thiolutin (THL), an inhibitor of the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease, blocks NLRP3 inflammasome activation by canonical, noncanonical, alternative, and transcription-independent pathways at nanomolar concentrations.	acetopyrrothine	30-33	NLR family, pyrin domain containing 3	Mus musculus	120-125
33931568-4	2021	In addition, THL potently inhibited the activation of multiple NLRP3 mutants linked with cryopyrin-associated periodic syndromes (CAPS).	acetopyrrothine	13-16	NLR family, pyrin domain containing 3	Mus musculus	63-68
33931568-5	2021	Treatment with THL alleviated NLRP3-related diseases in mouse models of lipopolysaccharide-induced sepsis, monosodium urate-induced peritonitis, experimental autoimmune encephalomyelitis, CAPS, and methionine-choline-deficient diet-induced nonalcoholic fatty liver disease.	acetopyrrothine	15-18	NLR family, pyrin domain containing 3	Mus musculus	30-35
33931568-6	2021	Mechanistic studies revealed that THL inhibits the BRCC3-containing isopeptidase complex (BRISC)-mediated NLRP3 deubiquitination and activation.	acetopyrrothine	34-37	NLR family, pyrin domain containing 3	Mus musculus	106-111
33931568-7	2021	In addition, we show that holomycin, a natural methyl derivative of THL, displays an even higher inhibitory activity against NLRP3 inflammasome than THL.	holomycin	26-35	NLR family, pyrin domain containing 3	Mus musculus	125-130
33931568-7	2021	In addition, we show that holomycin, a natural methyl derivative of THL, displays an even higher inhibitory activity against NLRP3 inflammasome than THL.	acetopyrrothine	68-71	NLR family, pyrin domain containing 3	Mus musculus	125-130
33931568-9	2021	Future clinical development of derivatives of THL may provide new therapies for NLRP3-related diseases.	acetopyrrothine	46-49	NLR family, pyrin domain containing 3	Mus musculus	80-85
33909257-9	2021	These results suggest that bavachin specifically enhances the ATP- or nigericin-induced activation of the NLRP3 inflammasome.	bavachin	27-35	NLR family, pyrin domain containing 3	Mus musculus	106-111
33909257-9	2021	These results suggest that bavachin specifically enhances the ATP- or nigericin-induced activation of the NLRP3 inflammasome.	Adenosine Triphosphate	62-65	NLR family, pyrin domain containing 3	Mus musculus	106-111
33909257-9	2021	These results suggest that bavachin specifically enhances the ATP- or nigericin-induced activation of the NLRP3 inflammasome.	Nigericin	70-79	NLR family, pyrin domain containing 3	Mus musculus	106-111
33915296-8	2021	MDN dose-dependently activated PGC-1alpha, significantly reduced pyroptosis, mtROS and the expressions of pyroptosis-associated proteins (NLRP3, ASC, cleaved caspase-1, IL-1beta, GSDMD-NT), and increased ZO-1 and Occludin protein expressions in BMVECs.	medioresinol	0-3	NLR family, pyrin domain containing 3	Mus musculus	138-143
33995030-0	2021	Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production.	Leflunomide	0-11	NLR family, pyrin domain containing 3	Mus musculus	84-89
33995030-8	2021	Results indicated that leflunomide induced dose-dependent pulmonary injury and the high dose and increased the vimentin, inflammatory markers (NLRP3 and interlukin-1beta).	Leflunomide	23-34	NLR family, pyrin domain containing 3	Mus musculus	143-148
33876420-0	2021	Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile mice.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	28-33
33876420-0	2021	Resveratrol reduces cardiac NLRP3-inflammasome activation and systemic inflammation to lessen doxorubicin-induced cardiotoxicity in juvenile mice.	Doxorubicin	94-105	NLR family, pyrin domain containing 3	Mus musculus	28-33
33876420-5	2021	Herein, we show that the cardiac NLRP3 inflammasome plays a crucial role in regulating cardiac injury in a doxorubicin-treated juvenile mouse model and the detrimental effects of hypertension in these mice later in life.	Doxorubicin	107-118	NLR family, pyrin domain containing 3	Mus musculus	33-38
33931568-1	2021	Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome activation results in potent therapeutic effects in a wide variety of preclinical inflammatory disease models.	Leucine	59-66	NLR family, pyrin domain containing 3	Mus musculus	139-144
33981238-7	2021	BSP administration accelerated diabetic wound healing, suppressed macrophage infiltration, promoted angiogenesis, suppressed NLRP3 inflammasome activation, decreased IL-1beta secretion, and improved insulin sensitivity in wound tissues in DM mice.	bsp	0-3	NLR family, pyrin domain containing 3	Mus musculus	125-130
33981238-8	2021	In vitro, co-treatment with BSP protected against HG-induced ROS generation, NLRP3 inflammasome activation, and IL-1beta secretion in BMDMs, and improved cell viability and decreased ROS levels in CMECs.	bsp	28-31	NLR family, pyrin domain containing 3	Mus musculus	77-82
33959014-14	2021	Further mechanistic investigation showed that DHB distinctly down-regulated renal mRNA and protein levels of URAT1, GLUT9, NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), caspase-1 and IL-1beta.	dihydroberberine	46-49	NLR family, pyrin domain containing 3	Mus musculus	144-149
33959014-15	2021	Our study revealed that DHB had outstanding hypouricemic and renoprotective effects via suppressing XOD, URAT1, GLUT9 and NLRP3 inflammasome activation in the kidney.	dihydroberberine	24-27	NLR family, pyrin domain containing 3	Mus musculus	122-127
33667712-0	2021	Btk knockout attenuates the liver inflammation in STZ-induced diabetic mice by suppressing NLRP3 inflammasome activation.	Streptozocin	50-53	NLR family, pyrin domain containing 3	Mus musculus	91-96
33863952-8	2021	Scopolamine treatment showed significant increase in the level of anxiety and impairments in memory and cognitive function associated with increased level of pro-inflammatory cytokines and NLRP3 inflammasome components.	Scopolamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	189-194
33674828-0	2021	Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-kappaB pathway and NLRP3 inflammasome activation in aged mice.	Atorvastatin	0-12	NLR family, pyrin domain containing 3	Mus musculus	124-129
33674828-12	2021	Atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines, including IL-1beta, TNF-alpha, and IL-6, accompanied by inhibiting the nuclear factor kappa-B (NF-kappaB) pathway and Nucleotide-Binding Oligomerization Domain, or Leucine Rich Repeat and Pyrin Domain Containing 3 (NLRP3) inflammasome activation, as well as hippocampal neuronal apoptosis.	Atorvastatin	0-12	NLR family, pyrin domain containing 3	Mus musculus	315-320
34041450-5	2021	Further study showed Nrf2 regulated reactive-oxygen-species-mediated Hippo-yes-associated protein (YAP) signaling, which in turn modulated the NLRP3 inflammasome activation.	Oxygen	45-51	NLR family, pyrin domain containing 3	Mus musculus	143-148
33954183-0	2021	NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition.	sodium bisulfide	0-4	NLR family, pyrin domain containing 3	Mus musculus	149-154
33954183-10	2021	NaHS treatment markedly improved the lung histological scores, the wet/dry weight ratio, bronchoalveolar lavage fluid (BALF) cell counts, BALF neutrophil counts, BALF neutrophil elastase activity, BALF protein concentration, PaO2/FiO2, mitochondrial morphology, the red/green fluorescence intensity that indicates changes in mitochondrial membrane potential, respiratory control rate (RCR), ATP, reactive oxygen species (ROS) release, and cell apoptosis via Nrf2-mediated NLRP3 pathway inhibition.	sodium bisulfide	0-4	NLR family, pyrin domain containing 3	Mus musculus	472-477
33883923-14	2021	Conclusion: ACY-1215 could inhibit the activation of M1 macrophages by improving the glycolytic pathway through regulating DNMT1 and DDX3X/NLRP3 signals to alleviate ALF.	ricolinostat	12-20	NLR family, pyrin domain containing 3	Mus musculus	139-144
33577850-0	2021	GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRbeta/Akt/NF-kappaB/NLRP3 pathway.	GYY 4137	0-7	NLR family, pyrin domain containing 3	Mus musculus	102-107
33577850-4	2021	This study aimed to investigate whether GYY4137 inhibits the activation of the pyrin domain-containing protein 3 (NLRP3) inflammasome by inhibiting the PDGFRbeta/Akt/NF-kappaB pathway.	GYY 4137	40-47	NLR family, pyrin domain containing 3	Mus musculus	114-119
33577850-10	2021	We discovered that GYY4137 reduced the levels of the p-PDGFRbeta, p-NF-kappaB, ASC, NLRP3, caspase-1, and p-Akt proteins in septic mouse lung tissue.	GYY 4137	19-26	NLR family, pyrin domain containing 3	Mus musculus	84-89
33954183-11	2021	Conclusion: NaHS protected against RIR-induced lung injury, mitochondrial dysfunction, and inflammation, which is associated with Nrf2 activation-mediated NLRP3 pathway inhibition.	sodium bisulfide	12-16	NLR family, pyrin domain containing 3	Mus musculus	155-160
33882517-5	2021	In this study, we demonstrate that memantine, a N-methyl-D-aspartic acid receptor (NMDAR) antagonist, through suppressing Ca2+ influx and subsequent ASC oligomerization inhibits macrophage Nlrp3 inflammasome activation and pyroptosis, therefore, alleviates ALI in septic mice.	Memantine	35-44	NLR family, pyrin domain containing 3	Mus musculus	189-194
33862553-0	2021	Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.	alpinetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	130-135
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	NLR family, pyrin domain containing 3	Mus musculus	68-73
33862553-10	2021	Overall, these findings suggested that the anti-fibrotic effect of alpinetin can be attributed to the inhibition of NLRP3-mediated anti-inflammatory activities and Nrf2-mediated anti-oxidative activities, in addition to the decrement of hepatic angiogenesis.	alpinetin	67-76	NLR family, pyrin domain containing 3	Mus musculus	116-121
33830232-3	2021	In this study, we found that ACA suppressed NLRP3 inflammasome activation in mouse bone marrow-derived macrophages and human THP-1 monocytes.	Acetates	29-32	NLR family, pyrin domain containing 3	Mus musculus	44-49
33830232-7	2021	ACA also prevented NLRP3 inflammasome activation in vivo, as evidenced in the MSU crystal-induced peritonitis and dextran sodium sulfate (DSS)-induced colitis mouse models accompanied by decreased Caspase-1 activation.	Acetates	0-3	NLR family, pyrin domain containing 3	Mus musculus	19-24
33830232-0	2021	1"-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.	1'-acetoxychavicol acetate	0-26	NLR family, pyrin domain containing 3	Mus musculus	36-41
33830232-8	2021	Thus, ACA is a potent inhibitor of the NLRP3 inflammasome for prevention of NLRP3-associated inflammatory diseases.	Acetates	6-9	NLR family, pyrin domain containing 3	Mus musculus	39-44
33830232-0	2021	1"-acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression.	Reactive Oxygen Species	94-97	NLR family, pyrin domain containing 3	Mus musculus	36-41
33830232-8	2021	Thus, ACA is a potent inhibitor of the NLRP3 inflammasome for prevention of NLRP3-associated inflammatory diseases.	Acetates	6-9	NLR family, pyrin domain containing 3	Mus musculus	76-81
33524801-0	2021	Epigallocatechin-3-gallate prevents inflammation and diabetes -Induced glucose tolerance through inhibition of NLRP3 inflammasome activation.	epigallocatechin gallate	0-26	NLR family, pyrin domain containing 3	Mus musculus	111-116
33917140-13	2021	In an adenine diet-induced CKD mouse model, phosphoramidon attenuated the progression of CKD by regulating autophagy, the NLRP3 inflammasome and ER stress.	phosphoramidon	44-58	NLR family, pyrin domain containing 3	Mus musculus	122-127
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	NLR family, pyrin domain containing 3	Mus musculus	127-132
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	NLR family, pyrin domain containing 3	Mus musculus	224-229
33987329-8	2021	Furthermore, 3-methyladenine, an autophagy inhibitor, abolished lycopene"s inhibitory effect on the NLRP3 inflammasome in KCs, which led to increased hepatic IR injury.	3-methyladenine	13-28	NLR family, pyrin domain containing 3	Mus musculus	100-105
33987329-8	2021	Furthermore, 3-methyladenine, an autophagy inhibitor, abolished lycopene"s inhibitory effect on the NLRP3 inflammasome in KCs, which led to increased hepatic IR injury.	Lycopene	64-72	NLR family, pyrin domain containing 3	Mus musculus	100-105
33987329-10	2021	Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury.	Lycopene	74-82	NLR family, pyrin domain containing 3	Mus musculus	126-131
33987329-11	2021	Conclusions: Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury.	Lycopene	44-52	NLR family, pyrin domain containing 3	Mus musculus	118-123
33543323-5	2021	OTA administration significantly increased histological injury and renal fibrosis molecules (alpha-SMA, Vimentin, TGF-beta) and activated the NOD-like receptor protein 3 (NLRP3) inflammasome and induced pyroptosis compared with control.	ochratoxin A	0-3	NLR family, pyrin domain containing 3	Mus musculus	171-176
33021112-0	2021	The cross-talk of NLRP3 inflammasome activation and necroptotic hepatocyte death in acetaminophen-induced mice acute liver injury.	Acetaminophen	84-97	NLR family, pyrin domain containing 3	Mus musculus	18-23
33021112-3	2021	However, the mechanistic linkage between necroptosis and NLRP3 inflammasome pathway in APAP-induced hepatotoxicity remains poorly understood.	Acetaminophen	87-91	NLR family, pyrin domain containing 3	Mus musculus	57-62
33021112-7	2021	Furthermore, the expression of critical molecules in NLRP3 inflammasome and necroptosis pathways peaked at 12-24 h, and then was decreased gradually, which is consistent with the pattern of pathological injury induced by APAP.	Acetaminophen	221-225	NLR family, pyrin domain containing 3	Mus musculus	53-58
33021112-9	2021	Furthermore, inhibition of necroptosis with necrostatin-1 significantly suppressed the activation of NLRP3 inflammasome signaling.	necrostatin-1	44-57	NLR family, pyrin domain containing 3	Mus musculus	101-106
33021112-10	2021	Taken together, our results highlighted that the cross-talk between necroptosis and NLRP3 inflammasome played a critical role for promoting APAP-induced liver injury.	Acetaminophen	140-144	NLR family, pyrin domain containing 3	Mus musculus	84-89
33022049-10	2021	Furthermore, a miR-130a-3p inhibitor significantly suppressed NLRP3 inflammasome activity by inducing autophagy in a mouse macrophage cell line (RAW264.7).	mir-130a-3p	15-26	NLR family, pyrin domain containing 3	Mus musculus	62-67
33823428-0	2021	MIF inhibitor ISO-1 alleviates severe acute pancreatitis-associated acute kidney injury by suppressing the NLRP3 inflammasome signaling pathway.	ISO-1	14-19	NLR family, pyrin domain containing 3	Mus musculus	107-112
33996256-9	2021	The in vivo studies revealed that FABP4 inhibitor BMS309403 ameliorated PE clinical phenotypes, the Treg/Th17 imbalance, and NLRP3 inflammasome activation in PE mice model.	2-(2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)biphenyl-3-yloxy)acetic acid	50-59	NLR family, pyrin domain containing 3	Mus musculus	125-130
33987329-0	2021	Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.	Lycopene	0-8	NLR family, pyrin domain containing 3	Mus musculus	91-96
33517224-0	2021	Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	107-112
33517224-0	2021	Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.	ai-44	18-23	NLR family, pyrin domain containing 3	Mus musculus	107-112
33517224-0	2021	Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.	Uric Acid	35-38	NLR family, pyrin domain containing 3	Mus musculus	107-112
33517224-4	2021	In this study, we explored the curcumin analogue AI-44 alleviated the gouty arthritis in mice via suppressing MSU engaging NLRP3 inflammasome activation.	Curcumin	31-39	NLR family, pyrin domain containing 3	Mus musculus	123-128
33524801-3	2021	In this study, we assessed the potential pathways by which EGCG regulates NLRP3 inflammasome activity in vitro.	epigallocatechin gallate	59-63	NLR family, pyrin domain containing 3	Mus musculus	74-79
33524801-4	2021	We found that EGCG inhibits caspase-1 activation and IL-1beta secretion by suppressing NLRP3 inflammasome activation in mouse bone marrow-derived macrophages (BMDMs).	epigallocatechin gallate	14-18	NLR family, pyrin domain containing 3	Mus musculus	87-92
33517224-4	2021	In this study, we explored the curcumin analogue AI-44 alleviated the gouty arthritis in mice via suppressing MSU engaging NLRP3 inflammasome activation.	ai-44	49-54	NLR family, pyrin domain containing 3	Mus musculus	123-128
33524801-5	2021	EGCG was also observed to block NLRP3-mediated ASC speckle formation and to alleviate pyroptosis in BMDMs.	epigallocatechin gallate	0-4	NLR family, pyrin domain containing 3	Mus musculus	32-37
33517224-5	2021	Furthermore, we demonstrated that AI-44 inhibited the interaction of cathepsin B and NLRP3 to prevent the activation of NLRP3 inflammasome.	ai-44	34-39	NLR family, pyrin domain containing 3	Mus musculus	85-90
33517224-5	2021	Furthermore, we demonstrated that AI-44 inhibited the interaction of cathepsin B and NLRP3 to prevent the activation of NLRP3 inflammasome.	ai-44	34-39	NLR family, pyrin domain containing 3	Mus musculus	120-125
33524801-6	2021	In addition, EGCG treatment could improve high-fat diet (HFD)-induced glucose tolerance and prevent NLRP3 inflammasome-dependent inflammation in a mouse model of HFD-induced type 2 diabetes (T2D).	epigallocatechin gallate	13-17	NLR family, pyrin domain containing 3	Mus musculus	100-105
33517224-7	2021	Collectively, these data suggest that AI-44 is a novel drug candidate for the treatment of gouty arthritis through targeting cathepsin B and inhibiting NLRP3 inflammasome activation.	ai-44	38-43	NLR family, pyrin domain containing 3	Mus musculus	152-157
33524801-7	2021	Taken together, our results show that EGCG is a general inhibitor of NLRP3 inflammasome activation and administration of EGCG in T2D mice could improve glucose tolerance in vivo.	epigallocatechin gallate	38-42	NLR family, pyrin domain containing 3	Mus musculus	69-74
33169332-0	2021	NLRP3 Inflammasome Inhibition Prevents alpha-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	111-115	NLR family, pyrin domain containing 3	Mus musculus	0-5
33607539-8	2021	Moreover, alleviation of Cd-induced NLRP3 inflammasome activation by PU was distinctly prevented by Nrf2 knockdown, assessed by protein levels of NLRP3 inflammosome complex and downstream IL-18 and IL-1beta production.	Cadmium	25-27	NLR family, pyrin domain containing 3	Mus musculus	36-41
33607539-8	2021	Moreover, alleviation of Cd-induced NLRP3 inflammasome activation by PU was distinctly prevented by Nrf2 knockdown, assessed by protein levels of NLRP3 inflammosome complex and downstream IL-18 and IL-1beta production.	Cadmium	25-27	NLR family, pyrin domain containing 3	Mus musculus	146-151
33607539-8	2021	Moreover, alleviation of Cd-induced NLRP3 inflammasome activation by PU was distinctly prevented by Nrf2 knockdown, assessed by protein levels of NLRP3 inflammosome complex and downstream IL-18 and IL-1beta production.	puerarin	69-71	NLR family, pyrin domain containing 3	Mus musculus	36-41
33607539-8	2021	Moreover, alleviation of Cd-induced NLRP3 inflammasome activation by PU was distinctly prevented by Nrf2 knockdown, assessed by protein levels of NLRP3 inflammosome complex and downstream IL-18 and IL-1beta production.	puerarin	69-71	NLR family, pyrin domain containing 3	Mus musculus	146-151
33607539-9	2021	Collectively, our data suggest that PU restores Cd-induced Nrf2 inhibition to prevent autophagy inhibition and NLRP3 inflammasome activation, providing novel insights into the protection of PU against Cd-induced hepatic cell damage.	puerarin	36-38	NLR family, pyrin domain containing 3	Mus musculus	111-116
33607539-9	2021	Collectively, our data suggest that PU restores Cd-induced Nrf2 inhibition to prevent autophagy inhibition and NLRP3 inflammasome activation, providing novel insights into the protection of PU against Cd-induced hepatic cell damage.	Cadmium	48-50	NLR family, pyrin domain containing 3	Mus musculus	111-116
33792721-10	2021	Despite the presence of inflammatory and oxidative stress, when GG retained the expression of AMPK/SIRT1, it could be observed that the downstream NLRP3 inflammatory-related proteins were inhibited.	genipin 1-gentiobioside	64-66	NLR family, pyrin domain containing 3	Mus musculus	147-152
32703610-11	2021	PPARdelta agonists also reduce the NLRP3 inflammasome-associated neural inflammation in the MPTP PD model in mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	92-96	NLR family, pyrin domain containing 3	Mus musculus	35-40
33607539-0	2021	Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells.	puerarin	0-8	NLR family, pyrin domain containing 3	Mus musculus	104-109
33576456-17	2021	The results of the present study suggested that PVT1 modulated NLRP3-mediated pyroptosis in septic AKI by targeting miR-20a-5p, which might suggest significant potential therapeutic targets for septic AKI.	mir-20a-5p	116-126	NLR family, pyrin domain containing 3	Mus musculus	63-68
33169332-0	2021	NLRP3 Inflammasome Inhibition Prevents alpha-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	111-115	NLR family, pyrin domain containing 3	Mus musculus	124-129
33169332-1	2021	Recent researches showed that nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome inhibition exerted dopaminergic neuroprotection in cellular or animal models of Parkinson"s disease (PD).	Leucine	60-67	NLR family, pyrin domain containing 3	Mus musculus	91-96
33169332-5	2021	In the present study, we investigate whether NLRP3 inflammasome inhibition prevents alpha-synuclein pathology by relieving autophagy dysfunction in the chronic 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	160-207	NLR family, pyrin domain containing 3	Mus musculus	45-50
33169332-5	2021	In the present study, we investigate whether NLRP3 inflammasome inhibition prevents alpha-synuclein pathology by relieving autophagy dysfunction in the chronic 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	209-213	NLR family, pyrin domain containing 3	Mus musculus	45-50
33169332-6	2021	NLRP3 knockout mice and their wild-type counterparts were treated with continuous MPTP administration via osmotic mini-pumps.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	82-86	NLR family, pyrin domain containing 3	Mus musculus	0-5
33169332-12	2021	Our results show that NLRP3 inflammasome inhibition via NLRP3 knockout not only protects against nigral dopaminergic degeneration and striatal dopamine deletion but also prevents nigral pathological alpha-synuclein formation in PD mice.	Dopamine	104-112	NLR family, pyrin domain containing 3	Mus musculus	22-27
33169332-12	2021	Our results show that NLRP3 inflammasome inhibition via NLRP3 knockout not only protects against nigral dopaminergic degeneration and striatal dopamine deletion but also prevents nigral pathological alpha-synuclein formation in PD mice.	Dopamine	104-112	NLR family, pyrin domain containing 3	Mus musculus	56-61
33859564-7	2021	Besides, the activation of NF-kappaB pathway and NLRP3 inflammasome was markedly inhibited by OCOP.	ocop	94-98	NLR family, pyrin domain containing 3	Mus musculus	49-54
32990912-7	2021	Our in vivo and in vitro studies revealed that LG could alleviate the inflammation response, reflected by the reduction of NLRP3 and cleaved caspase-1.	liquiritigenin	47-49	NLR family, pyrin domain containing 3	Mus musculus	123-128
33859564-9	2021	Taken together, the protective effect of OCOP against DSS-induced colitis might be intimately related to inhibition of NF-kappaB pathway and NLRP3 inflammasome.	Dextran Sulfate	54-57	NLR family, pyrin domain containing 3	Mus musculus	141-146
33859564-9	2021	Taken together, the protective effect of OCOP against DSS-induced colitis might be intimately related to inhibition of NF-kappaB pathway and NLRP3 inflammasome.	ocop	41-45	NLR family, pyrin domain containing 3	Mus musculus	141-146
33854503-0	2021	Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation.	Lactic Acid	0-11	NLR family, pyrin domain containing 3	Mus musculus	41-46
33854503-2	2021	We previously showed that glycolysis, a metabolic pathway that converts glucose into pyruvate, is essential for NLRP3 inflammasome activation in macrophages.	Glucose	72-79	NLR family, pyrin domain containing 3	Mus musculus	112-117
33854503-6	2021	By contrast, decreasing the activity of pyruvate oxidation by depletion of either mitochondrial pyruvate carrier 2 (MPC2) or pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) enhanced NLRP3 inflammasome activation, suggesting that inhibition of mitochondrial pyruvate transport enhanced lactic acid fermentation.	Lactic Acid	287-298	NLR family, pyrin domain containing 3	Mus musculus	184-189
33854503-2	2021	We previously showed that glycolysis, a metabolic pathway that converts glucose into pyruvate, is essential for NLRP3 inflammasome activation in macrophages.	Pyruvic Acid	85-93	NLR family, pyrin domain containing 3	Mus musculus	112-117
33854503-7	2021	Moreover, treatment with GSK2837808A reduced MSU-mediated peritonitis in mice, a disease model used for studying the consequences of NLRP3 inflammasome activation.	GSK2837808A	25-36	NLR family, pyrin domain containing 3	Mus musculus	133-138
33854503-8	2021	Our results suggest that lactic acid fermentation is important for NLRP3 inflammasome activation, while pyruvate oxidation is not.	Lactic Acid	25-36	NLR family, pyrin domain containing 3	Mus musculus	67-72
33854503-3	2021	Here, we investigated the role of metabolic pathways downstream glycolysis - lactic acid fermentation and pyruvate oxidation-in activation of the NLRP3 inflammasome.	Lactic Acid	77-88	NLR family, pyrin domain containing 3	Mus musculus	146-151
33854503-9	2021	Thus, reprograming pyruvate metabolism in mitochondria and in the cytoplasm should be considered as a novel strategy for the treatment of NLRP3 inflammasome-associated diseases.	Pyruvic Acid	19-27	NLR family, pyrin domain containing 3	Mus musculus	138-143
33854503-3	2021	Here, we investigated the role of metabolic pathways downstream glycolysis - lactic acid fermentation and pyruvate oxidation-in activation of the NLRP3 inflammasome.	Pyruvic Acid	106-114	NLR family, pyrin domain containing 3	Mus musculus	146-151
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Lactic Acid	69-80	NLR family, pyrin domain containing 3	Mus musculus	206-211
33783035-0	2021	Ginsenoside Re protects against chronic restraint stress-induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice.	Ginsenosides	0-11	NLR family, pyrin domain containing 3	Mus musculus	106-111
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Lactic Acid	69-80	NLR family, pyrin domain containing 3	Mus musculus	357-362
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Nigericin	242-251	NLR family, pyrin domain containing 3	Mus musculus	206-211
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Adenosine Triphosphate	253-256	NLR family, pyrin domain containing 3	Mus musculus	206-211
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Uric Acid	258-274	NLR family, pyrin domain containing 3	Mus musculus	206-211
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Uric Acid	276-279	NLR family, pyrin domain containing 3	Mus musculus	206-211
33854503-4	2021	Using pharmacological or genetic approaches, we show that decreasing lactic acid fermentation by inhibiting lactate dehydrogenase reduced caspase-1 activation and IL-1beta maturation in response to various NLRP3 inflammasome agonists such as nigericin, ATP, monosodium urate (MSU) crystals, or alum, indicating that lactic acid fermentation is required for NLRP3 inflammasome activation.	Lactic Acid	316-327	NLR family, pyrin domain containing 3	Mus musculus	206-211
33854503-5	2021	Inhibition of lactate dehydrogenase with GSK2837808A reduced lactate production and activity of the NLRP3 inflammasome regulator, phosphorylated protein kinase R (PKR), but did not reduce the common trigger of NLRP3 inflammasome, potassium efflux, or reactive oxygen species (ROS) production.	GSK2837808A	41-52	NLR family, pyrin domain containing 3	Mus musculus	100-105
33854503-5	2021	Inhibition of lactate dehydrogenase with GSK2837808A reduced lactate production and activity of the NLRP3 inflammasome regulator, phosphorylated protein kinase R (PKR), but did not reduce the common trigger of NLRP3 inflammasome, potassium efflux, or reactive oxygen species (ROS) production.	Lactic Acid	14-21	NLR family, pyrin domain containing 3	Mus musculus	100-105
33854503-5	2021	Inhibition of lactate dehydrogenase with GSK2837808A reduced lactate production and activity of the NLRP3 inflammasome regulator, phosphorylated protein kinase R (PKR), but did not reduce the common trigger of NLRP3 inflammasome, potassium efflux, or reactive oxygen species (ROS) production.	Lactic Acid	14-21	NLR family, pyrin domain containing 3	Mus musculus	210-215
33854503-6	2021	By contrast, decreasing the activity of pyruvate oxidation by depletion of either mitochondrial pyruvate carrier 2 (MPC2) or pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) enhanced NLRP3 inflammasome activation, suggesting that inhibition of mitochondrial pyruvate transport enhanced lactic acid fermentation.	Pyruvic Acid	40-48	NLR family, pyrin domain containing 3	Mus musculus	184-189
33854503-6	2021	By contrast, decreasing the activity of pyruvate oxidation by depletion of either mitochondrial pyruvate carrier 2 (MPC2) or pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1) enhanced NLRP3 inflammasome activation, suggesting that inhibition of mitochondrial pyruvate transport enhanced lactic acid fermentation.	Pyruvic Acid	96-104	NLR family, pyrin domain containing 3	Mus musculus	184-189
33242622-1	2021	& Kitam suppresses LPS-induced cytokine production and NLRP3 inflammasome activation in macrophages and alleviates carrageenan-induced acute inflammation in mice.	Carrageenan	115-126	NLR family, pyrin domain containing 3	Mus musculus	55-60
33645621-7	2021	In addition, ACG treatment remarkably down-regulated the expression of TLR4, p-P65, NLRP3, Caspase-1 and adenosquamous carcinoma (ASC) in lung tissue.	acg	13-16	NLR family, pyrin domain containing 3	Mus musculus	84-89
33621212-7	2021	IL1beta production by NCM was NLRP3 inflammasome-dependent and inhibited by treatment with a clinically approved sulphonylurea.	Sulfonylurea Compounds	113-126	NLR family, pyrin domain containing 3	Mus musculus	30-35
33323396-2	2021	We investigated whether inhibiting the NLRP3-inflammasome, through the use of the specific small-molecule NLRP3 inhibitor, MCC950, could reduce inflammation, improve vascular function and protect against diabetes-associated atherosclerosis in the streptozotocin (STZ)-induced diabetic Apolipoprotein knockout (ApoE-/-) mouse.	Streptozocin	247-261	NLR family, pyrin domain containing 3	Mus musculus	39-44
33723236-0	2021	NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin.	irisin	144-150	NLR family, pyrin domain containing 3	Mus musculus	0-5
33723236-8	2021	Furthermore, ectopic overexpression of NLRP3 abrogated the cardioprotective effects of irisin.	irisin	87-93	NLR family, pyrin domain containing 3	Mus musculus	39-44
33723236-9	2021	To summarize, pyroptosis is a pathological factor in cardiac hypertrophy, and irisin is a promising therapeutic agent that inhibits NLRP3-mediated pyroptosis of cardiomyocytes.	irisin	78-84	NLR family, pyrin domain containing 3	Mus musculus	132-137
33620070-0	2021	Inflammatory effect of Bothropstoxin-I from Bothrops jararacussu venom mediated by NLRP3 inflammasome involves ATP and P2X7 receptor.	Adenosine Triphosphate	111-114	NLR family, pyrin domain containing 3	Mus musculus	83-88
33620070-9	2021	These findings demonstrated the inflammatory effect of BthTX-I on muscle tissue, pointing out a role for the ATP released by damaged cells for the NLRP3 activation on macrophages, contributing to the understanding of the microenvironment of the tissue damage of the Bothrops envenomation.	Adenosine Triphosphate	109-112	NLR family, pyrin domain containing 3	Mus musculus	147-152
33707964-7	2021	The expression of nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC), caspase-1, and GSDMD-N in LPS/ATP-stimulated cells were examined by Western blot.	Adenosine Triphosphate	241-244	NLR family, pyrin domain containing 3	Mus musculus	18-99
33707964-9	2021	Results: Punicalin significantly blocked the production of endogenous ROS, reduced LPS/ATP-induced activation of NLRP3, caspase 1, ASC and GSDMD-N, IL-1b and IL-18 protein levels.	punicalin	9-18	NLR family, pyrin domain containing 3	Mus musculus	113-118
33707964-9	2021	Results: Punicalin significantly blocked the production of endogenous ROS, reduced LPS/ATP-induced activation of NLRP3, caspase 1, ASC and GSDMD-N, IL-1b and IL-18 protein levels.	Adenosine Triphosphate	87-90	NLR family, pyrin domain containing 3	Mus musculus	113-118
33707964-10	2021	Furthermore, N-acetylcysteine (NAC), an ROS scavenger, inhibited the LPS/ATP-stimulated activation of NLRP3 inflammasome mediated inflammation and pyroptosis.	Acetylcysteine	13-29	NLR family, pyrin domain containing 3	Mus musculus	102-107
33707964-10	2021	Furthermore, N-acetylcysteine (NAC), an ROS scavenger, inhibited the LPS/ATP-stimulated activation of NLRP3 inflammasome mediated inflammation and pyroptosis.	Acetylcysteine	31-34	NLR family, pyrin domain containing 3	Mus musculus	102-107
33707964-10	2021	Furthermore, N-acetylcysteine (NAC), an ROS scavenger, inhibited the LPS/ATP-stimulated activation of NLRP3 inflammasome mediated inflammation and pyroptosis.	ros	40-43	NLR family, pyrin domain containing 3	Mus musculus	102-107
33707964-10	2021	Furthermore, N-acetylcysteine (NAC), an ROS scavenger, inhibited the LPS/ATP-stimulated activation of NLRP3 inflammasome mediated inflammation and pyroptosis.	Adenosine Triphosphate	73-76	NLR family, pyrin domain containing 3	Mus musculus	102-107
33707964-11	2021	Conclusion: Punicalin ameliorates LPS/ATP-induced pyroptosis in J774A.1 macrophages, the mechanism may involve downregulation of the ROS/NLRP3 inflammasome signaling pathway.	punicalin	12-21	NLR family, pyrin domain containing 3	Mus musculus	137-142
33707964-11	2021	Conclusion: Punicalin ameliorates LPS/ATP-induced pyroptosis in J774A.1 macrophages, the mechanism may involve downregulation of the ROS/NLRP3 inflammasome signaling pathway.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	137-142
33746978-0	2021	Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture.	Uric Acid	26-42	NLR family, pyrin domain containing 3	Mus musculus	51-56
33746978-0	2021	Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture.	Oxygen	107-113	NLR family, pyrin domain containing 3	Mus musculus	51-56
33746978-5	2021	In this study, we clarified the actions of DcR3 and its non-decoy action motif heparin sulfate proteoglycan (HSPG) binding domain (HBD) in the MSU crystal-induced NLRP3 inflammasome activation in the macrophages and in mice.	Heparin	79-86	NLR family, pyrin domain containing 3	Mus musculus	163-168
33746978-5	2021	In this study, we clarified the actions of DcR3 and its non-decoy action motif heparin sulfate proteoglycan (HSPG) binding domain (HBD) in the MSU crystal-induced NLRP3 inflammasome activation in the macrophages and in mice.	Uric Acid	143-146	NLR family, pyrin domain containing 3	Mus musculus	163-168
33692106-4	2021	Thus, the MN-enabled transdermal codelivery of Cas9 RNP nanocomplexes and Dex nanoparticles result in the disruption of subcutaneous intracellular NLRP3 inflammasomes, which is demonstrated to be critical to alleviate skin inflammations and contributes to glucocorticoid therapy in mouse models of ISDs, including psoriasis and atopic dermatitis.	Dexamethasone	74-77	NLR family, pyrin domain containing 3	Mus musculus	147-152
33746978-10	2021	These findings indicate that HBD of DcR3 can reduce MSU crystal-induced NLRP3 inflammasome activation via modulation of mitochondrial and lysosomal functions.	Uric Acid	52-55	NLR family, pyrin domain containing 3	Mus musculus	72-77
33977048-8	2021	As NLRP3 inflammasome can be activated by ER stress, 3-HB can inhibit the activation of NLRP3 inflammasome, which triggers the increase of M1 macrophage proportion and the inhibition of cholesterol efflux.	Cholesterol	186-197	NLR family, pyrin domain containing 3	Mus musculus	3-8
33977048-8	2021	As NLRP3 inflammasome can be activated by ER stress, 3-HB can inhibit the activation of NLRP3 inflammasome, which triggers the increase of M1 macrophage proportion and the inhibition of cholesterol efflux.	Cholesterol	186-197	NLR family, pyrin domain containing 3	Mus musculus	88-93
33549002-10	2021	Further study showed that Scu inhibited the activation of nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) and activated phospho-protein kinase B (p-AKT), nuclear factor E2-related factor 2 (Nrf2), and heme oxygenase (HO-1).	scutellarin	26-29	NLR family, pyrin domain containing 3	Mus musculus	137-142
33783986-7	2021	The activation of NLRP3 inflammasome in RTECs by hemes was investigated by Western blot, ELISA, scanning electron microscopy, immunofluorescent staining, flow cytometry, and hemolysis models.	Heme	49-54	NLR family, pyrin domain containing 3	Mus musculus	18-23
33783986-11	2021	RESULTS: We found that heme could activate NLRP3 inflammasome in RTECs to induce kidney function injury.	Heme	23-27	NLR family, pyrin domain containing 3	Mus musculus	43-48
33783986-12	2021	NLRP3 gene knockout could prevent the damage of RTECs caused by hemes and recover kidney function in AHTR.	Heme	64-69	NLR family, pyrin domain containing 3	Mus musculus	0-5
33783986-13	2021	Moreover, NLRP3 inflammasome chemical inhibitor, 66PR, could bind to NLRP3 protein and inhibit inflammasome activation in RTECs, which consequently relieved the injury of RTECs caused by hemes, and alleviated kidney function damage in the AHTR model.	Heme	187-192	NLR family, pyrin domain containing 3	Mus musculus	10-15
33783986-13	2021	Moreover, NLRP3 inflammasome chemical inhibitor, 66PR, could bind to NLRP3 protein and inhibit inflammasome activation in RTECs, which consequently relieved the injury of RTECs caused by hemes, and alleviated kidney function damage in the AHTR model.	Heme	187-192	NLR family, pyrin domain containing 3	Mus musculus	69-74
33783986-14	2021	CONCLUSIONS: Hemes could activate NLRP3 inflammasome in RTECs, and a novel NLRP3 inflammasome inhibitor named 66PR relieved kidney function damage in AHTR.	Heme	13-18	NLR family, pyrin domain containing 3	Mus musculus	34-39
33323396-2	2021	We investigated whether inhibiting the NLRP3-inflammasome, through the use of the specific small-molecule NLRP3 inhibitor, MCC950, could reduce inflammation, improve vascular function and protect against diabetes-associated atherosclerosis in the streptozotocin (STZ)-induced diabetic Apolipoprotein knockout (ApoE-/-) mouse.	Streptozocin	247-261	NLR family, pyrin domain containing 3	Mus musculus	106-111
33323396-2	2021	We investigated whether inhibiting the NLRP3-inflammasome, through the use of the specific small-molecule NLRP3 inhibitor, MCC950, could reduce inflammation, improve vascular function and protect against diabetes-associated atherosclerosis in the streptozotocin (STZ)-induced diabetic Apolipoprotein knockout (ApoE-/-) mouse.	Streptozocin	263-266	NLR family, pyrin domain containing 3	Mus musculus	39-44
33387462-4	2021	Our results showed that CPZ treatment significantly increased the expression of Trpv4, activated Nlrp3 inflammasome, reduced peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) and decreased mitochondrial function.	Chlorpromazine	24-27	NLR family, pyrin domain containing 3	Mus musculus	97-102
33387462-8	2021	Furthermore, immunoprecipitation and use of a lysine acetylation assay showed that Sirtuin1 (SIRT1) mediated the PGC-1alpha deacetylation, which is involved in Nlrp3 inflammasome activation.	Lysine	46-52	NLR family, pyrin domain containing 3	Mus musculus	160-165
33387462-9	2021	These findings suggest that Trpv4 regulates mitochondrial function through the SIRT1/PGC-1alpha pathway, which further trigger Nlrp3 inflammasome activation in the CPZ-induced demyelination in mice.	Chlorpromazine	164-167	NLR family, pyrin domain containing 3	Mus musculus	127-132
33523066-13	2021	EPA also inhibited NLRP3/IL-1beta and IL-6/STAT3 inflammatory pathways and up-regulated the Wnt/beta-catenin pathway.	Eicosapentaenoic Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	19-24
33452670-9	2021	Moreover, by targeting ANO1, miR-144-3p inhibited the activation of NLRP3 inflammasome inflammatory signals in myocardial cells.	mir-144-3p	29-39	NLR family, pyrin domain containing 3	Mus musculus	68-73
33559709-0	2021	Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis.	celastrol	0-10	NLR family, pyrin domain containing 3	Mus musculus	125-130
33422760-7	2021	Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes.	psoralidin	10-20	NLR family, pyrin domain containing 3	Mus musculus	91-96
33422760-7	2021	Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes.	psoralidin	10-20	NLR family, pyrin domain containing 3	Mus musculus	197-202
33422760-7	2021	Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes.	psoralidin	163-173	NLR family, pyrin domain containing 3	Mus musculus	91-96
33422760-7	2021	Moreover, psoralidin significantly induced IL-1beta maturation and caspase-1 activation in NLRP3-knockout bone marrow-derived macrophages (BMDMs), suggesting that psoralidin not only activates the NLRP3 inflammasome but also activates other types of inflammasomes.	psoralidin	163-173	NLR family, pyrin domain containing 3	Mus musculus	197-202
33152436-13	2021	Importantly, increased hepatic expression of pro-inflammatory factors and the NLRP3 inflammasome, which have a positive correlation with differential bacteria, were characteristics found in DDC-induced cholestatic mice that were alleviated upon treatment with HQD.	Zalcitabine	190-193	NLR family, pyrin domain containing 3	Mus musculus	78-83
33655332-0	2021	Simiaosan alleviates the symptoms of gouty arthritis via the NALP3/IL-1beta pathway.	simiaosan	0-9	NLR family, pyrin domain containing 3	Mus musculus	61-66
33655332-9	2021	These results indicated that the effects of simiaosan were mediated through NALP3 inhibition.	simiaosan	44-53	NLR family, pyrin domain containing 3	Mus musculus	76-81
33655332-10	2021	Therefore, the herbal medicine simiaosan was revealed to possess an ability to alleviate the symptoms of GA by regulating the NALP3/IL-1beta signaling pathway.	simiaosan	31-40	NLR family, pyrin domain containing 3	Mus musculus	126-131
32918847-0	2021	NLRP3 inflammasome-derived interleukin-1beta attenuates stress-induced gastric injury via the COX-2/PGE2 axis.	Dinoprostone	100-104	NLR family, pyrin domain containing 3	Mus musculus	0-5
32918847-11	2021	PGE2 supplementation abolished the hypersensitivity in NLRP3-/- and caspase-1-/- mice through negative regulation of inflammatory cytokines.	Dinoprostone	0-4	NLR family, pyrin domain containing 3	Mus musculus	55-60
32918847-12	2021	CONCLUSION: These results suggest that NLRP3 inflammasome-derived IL-1beta plays a protective role in stress-induced gastric injury via activation of the COX-2/PGE2 axis.	Dinoprostone	160-164	NLR family, pyrin domain containing 3	Mus musculus	39-44
33268842-1	2021	NLRP3 inflammasome activation, which can be triggered by reactive oxygen species (ROS), contributes to nonalcoholic steatohepatitis (NASH) progression.	Reactive Oxygen Species	57-80	NLR family, pyrin domain containing 3	Mus musculus	0-5
33268842-1	2021	NLRP3 inflammasome activation, which can be triggered by reactive oxygen species (ROS), contributes to nonalcoholic steatohepatitis (NASH) progression.	Reactive Oxygen Species	82-85	NLR family, pyrin domain containing 3	Mus musculus	0-5
33268842-9	2021	We further explored the effect of adropin on the NLRP3 inflammasome in palmitic acid (PA)-treated hepatocytes and Kupffer cells.	Palmitic Acid	71-84	NLR family, pyrin domain containing 3	Mus musculus	49-54
33268842-9	2021	We further explored the effect of adropin on the NLRP3 inflammasome in palmitic acid (PA)-treated hepatocytes and Kupffer cells.	Palmitic Acid	86-88	NLR family, pyrin domain containing 3	Mus musculus	49-54
33432150-9	2021	We also show that the NLRP3 inflammasome is activated by a signalling cascade that involves the p21-activated kinases 1 and 2 (Pak1/2) and the Pak1-mediated phosphorylation of Thr 659 of NLRP3, which is necessary for the NLRP3-Nek7 interaction, inflammasome activation and IL-1beta cytokine maturation.	Threonine	176-179	NLR family, pyrin domain containing 3	Mus musculus	22-27
33432150-9	2021	We also show that the NLRP3 inflammasome is activated by a signalling cascade that involves the p21-activated kinases 1 and 2 (Pak1/2) and the Pak1-mediated phosphorylation of Thr 659 of NLRP3, which is necessary for the NLRP3-Nek7 interaction, inflammasome activation and IL-1beta cytokine maturation.	Threonine	176-179	NLR family, pyrin domain containing 3	Mus musculus	187-192
33432150-9	2021	We also show that the NLRP3 inflammasome is activated by a signalling cascade that involves the p21-activated kinases 1 and 2 (Pak1/2) and the Pak1-mediated phosphorylation of Thr 659 of NLRP3, which is necessary for the NLRP3-Nek7 interaction, inflammasome activation and IL-1beta cytokine maturation.	Threonine	176-179	NLR family, pyrin domain containing 3	Mus musculus	187-192
33549727-5	2021	RESULTS: Repeated treatment with morphine increased total expression of spinal TLR4, TAK1, and NLRP3 and phosphorylation of TAK1 in wild-type mice.	Morphine	33-41	NLR family, pyrin domain containing 3	Mus musculus	95-100
33515706-9	2021	Altogether, our results show that DPDS elicited neuroprotection in ALS models through inactivation of microglia by inhibiting IkappaB/NF-kappaB pathway and NLRP3 inflammasome activation, suggesting that DPDS may be a promising candidate for potential therapy for ALS.	diphenyldiselenide	34-38	NLR family, pyrin domain containing 3	Mus musculus	156-161
33515706-5	2021	Moreover, DPDS suppressed NLRP3 inflammasome activation by decreasing protein nitration via reduction in NO and ROS levels, whose low levels are related to NF-kappaB inhibition responsible for iNOS and NOX2 down-regulations, respectively.	diphenyldiselenide	10-14	NLR family, pyrin domain containing 3	Mus musculus	26-31
33549727-6	2021	TLR4 knockout attenuated morphine-induced tolerance and inhibited the chronic morphine-induced increase in NLRP3 and phosphorylation of TAK1.	Morphine	78-86	NLR family, pyrin domain containing 3	Mus musculus	107-112
33515706-5	2021	Moreover, DPDS suppressed NLRP3 inflammasome activation by decreasing protein nitration via reduction in NO and ROS levels, whose low levels are related to NF-kappaB inhibition responsible for iNOS and NOX2 down-regulations, respectively.	ros	112-115	NLR family, pyrin domain containing 3	Mus musculus	26-31
33549727-0	2021	Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance.	Morphine	120-128	NLR family, pyrin domain containing 3	Mus musculus	49-54
33549727-1	2021	BACKGROUND AND PURPOSE: The aim of this work was to investigate the role and signal transduction of toll-like receptor 4 (TLR4), TGF-beta-activated kinase 1 (TAK1) and nod-like receptor protein 3 (NLRP3) in microglial in the development of morphine-induced antinociceptive tolerance.	Morphine	240-248	NLR family, pyrin domain containing 3	Mus musculus	168-195
33641628-5	2021	Further, CCI rats, LPS and ATP treated N2A cells showed enhanced expression of NLRP3, ASC, Caspase-1 and IL-1beta.	Adenosine Triphosphate	27-30	NLR family, pyrin domain containing 3	Mus musculus	79-84
33641628-9	2021	Intriguingly, pretreatment of CRC (50 and 100 muM) to LPS and ATP treated N2A cells resulted in decreased colocalization of NLRP3 and ASC.Discussion: These findings revealed the neuroprotective potential of CRC against CCI induced NP and delineate the critical role of autophagy and mitochondrial quality control in NLRP3 regulation.	Adenosine Triphosphate	62-65	NLR family, pyrin domain containing 3	Mus musculus	124-129
33641628-9	2021	Intriguingly, pretreatment of CRC (50 and 100 muM) to LPS and ATP treated N2A cells resulted in decreased colocalization of NLRP3 and ASC.Discussion: These findings revealed the neuroprotective potential of CRC against CCI induced NP and delineate the critical role of autophagy and mitochondrial quality control in NLRP3 regulation.	Adenosine Triphosphate	62-65	NLR family, pyrin domain containing 3	Mus musculus	316-321
33641435-8	2021	Administration of rosuvastatin reduced the increases in expression of NLRP3, ASC, pro-caspase-1, TLR4, and p65 and decreased the contents of TNF-alpha, IL-1beta, IL-18 and IL-6, with a similar effect as MCC950 (NLRP3 inhibitor).	Rosuvastatin Calcium	18-30	NLR family, pyrin domain containing 3	Mus musculus	70-75
33641435-8	2021	Administration of rosuvastatin reduced the increases in expression of NLRP3, ASC, pro-caspase-1, TLR4, and p65 and decreased the contents of TNF-alpha, IL-1beta, IL-18 and IL-6, with a similar effect as MCC950 (NLRP3 inhibitor).	Rosuvastatin Calcium	18-30	NLR family, pyrin domain containing 3	Mus musculus	211-216
33549727-7	2021	Compared with controls, mice that received 5Z-7-oxozeaenol showed decreased development of morphine tolerance and inhibition on repeated morphine-induced increase of NLRP3 but not TLR4.	5-7-oxo-zeaenol	43-58	NLR family, pyrin domain containing 3	Mus musculus	166-171
33549727-7	2021	Compared with controls, mice that received 5Z-7-oxozeaenol showed decreased development of morphine tolerance and inhibition on repeated morphine-induced increase of NLRP3 but not TLR4.	Morphine	137-145	NLR family, pyrin domain containing 3	Mus musculus	166-171
33549727-8	2021	NLRP3 knockout mice showed resistance to morphine-induced analgesic tolerance with no effect on chronic morphine-induced expression of TLR4 and TAK1.	Morphine	41-49	NLR family, pyrin domain containing 3	Mus musculus	0-5
33549727-10	2021	CONCLUSIONS: Microglial TLR4 regulates TAK1 expression and phosphorylation and results in NLRP3 activation contributes to the development of morphine tolerance through regulating neuroinflammation.	Morphine	141-149	NLR family, pyrin domain containing 3	Mus musculus	90-95
33549727-11	2021	Targeting TLR4-TAK1-NLRP3 signaling to regulate neuro-inflammation will be alternative therapeutics and strategies for chronic morphine-induced antinociceptive tolerance.	Morphine	127-135	NLR family, pyrin domain containing 3	Mus musculus	20-25
33637069-11	2021	THJ treatment also inhibited the production of reactive oxygen species (ROS) and malondialdehyde (MDA), induced the production of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), decreased the levels of pro-inflammatory cytokines, and suppressed the activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome.	thj	0-3	NLR family, pyrin domain containing 3	Mus musculus	283-348
33641435-9	2021	In conclusion, inhibition of the inflammatory response and oxidative stress contributes to cardioprotection of rosuvastatin on cardiac injury induced by LPS, and the effect of rosuvastatin was achieved by inactivation of the NF-kappaB/NLRP3 pathway.	Rosuvastatin Calcium	176-188	NLR family, pyrin domain containing 3	Mus musculus	235-240
33637069-11	2021	THJ treatment also inhibited the production of reactive oxygen species (ROS) and malondialdehyde (MDA), induced the production of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), decreased the levels of pro-inflammatory cytokines, and suppressed the activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome.	thj	0-3	NLR family, pyrin domain containing 3	Mus musculus	350-355
33637069-13	2021	CONCLUSIONS: Overall, THJ protected the heart from hyperglycemia-induced oxidative stress and inflammation in DCM mice via a mechanism involving SIRT1-mediated antioxidant proteins and suppression of the NLRP3 inflammasome.	thj	22-25	NLR family, pyrin domain containing 3	Mus musculus	204-209
33728029-7	2021	Resveratrol also suppressed spleen tyrosine kinase (Syk) phosphorylation and nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) expression and IL-1beta secretion in ox-LDL- and LPS-treated platelets.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	77-143
33668885-11	2021	Furthermore, inhibition of lysosomal hyperpolarization with Bafilomycin A1 blocked LMP and NLRP3 activation, suggesting a causal relation between lysosomal hyperpolarization and LMP.	bafilomycin A1	60-74	NLR family, pyrin domain containing 3	Mus musculus	91-96
33717152-0	2021	NLRP3 Deficiency Protects Against Intermittent Hypoxia-Induced Neuroinflammation and Mitochondrial ROS by Promoting the PINK1-Parkin Pathway of Mitophagy in a Murine Model of Sleep Apnea.	Reactive Oxygen Species	99-102	NLR family, pyrin domain containing 3	Mus musculus	0-5
33717152-5	2021	Compared with wild-type mice, NLRP3 deficiency protected them from CIH-induced neuronal damage, as indicated by the restoration of fear-conditioning test results and amelioration of neuron apoptosis.	cih	67-70	NLR family, pyrin domain containing 3	Mus musculus	30-35
33717152-6	2021	In addition, NLRP3 knockout mice displayed the mitigated microglia activation that elicited by CIH, concomitantly with elimination of damaged mitochondria and reduction of oxidative stress levels (malondialdehyde and superoxide dismutase).	cih	95-98	NLR family, pyrin domain containing 3	Mus musculus	13-18
33717152-6	2021	In addition, NLRP3 knockout mice displayed the mitigated microglia activation that elicited by CIH, concomitantly with elimination of damaged mitochondria and reduction of oxidative stress levels (malondialdehyde and superoxide dismutase).	Malondialdehyde	197-212	NLR family, pyrin domain containing 3	Mus musculus	13-18
33717152-6	2021	In addition, NLRP3 knockout mice displayed the mitigated microglia activation that elicited by CIH, concomitantly with elimination of damaged mitochondria and reduction of oxidative stress levels (malondialdehyde and superoxide dismutase).	Superoxides	217-227	NLR family, pyrin domain containing 3	Mus musculus	13-18
33717152-11	2021	Furthermore, Parkin deletion or pretreated with 3MA (autophagy inhibitor) exacerbated these detrimental actions of IH, which was accompanied with NLRP3 inflammasome activation.	3-methyladenine	48-51	NLR family, pyrin domain containing 3	Mus musculus	146-151
33717152-12	2021	These results revealed NLRP3 deficiency acted as a protective promotor through enhancing Parkin-depended mitophagy in CIH-induced neuroinflammation.	cih	118-121	NLR family, pyrin domain containing 3	Mus musculus	23-28
33728029-0	2021	Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	64-69
33728029-7	2021	Resveratrol also suppressed spleen tyrosine kinase (Syk) phosphorylation and nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) expression and IL-1beta secretion in ox-LDL- and LPS-treated platelets.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	145-150
33728029-8	2021	The coimmunoprecipitation results showed that resveratrol inhibited the binding of Syk and NLRP3.	Resveratrol	46-57	NLR family, pyrin domain containing 3	Mus musculus	91-96
33728029-12	2021	The mechanism of action of resveratrol appears to be associated with the inhibition of TLR4/Syk/NLRP3 activation in ox-LDL-activated platelets.	Resveratrol	27-38	NLR family, pyrin domain containing 3	Mus musculus	96-101
33612104-1	2021	BACKGROUND: This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms.	Ceramides	55-63	NLR family, pyrin domain containing 3	Mus musculus	73-78
33676236-0	2021	Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.	oridonin	22-30	NLR family, pyrin domain containing 3	Mus musculus	94-99
33676236-1	2021	NOD-like receptor protein 3 (NLRP3) inflammasome is tightly related to the pathogenesis of cerebral ischemia/reperfusion (I/R) injury, and oridonin (Ori) has shown the potential to alleviate ischemia/reperfusion injury with underlying mechanisms.	oridonin	139-147	NLR family, pyrin domain containing 3	Mus musculus	29-34
33612104-2	2021	METHODS: Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages was used as an in vitro model of inflammation.	Adenosine	34-43	NLR family, pyrin domain containing 3	Mus musculus	71-76
33612104-1	2021	BACKGROUND: This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms.	Ceramides	65-68	NLR family, pyrin domain containing 3	Mus musculus	73-78
33612104-2	2021	METHODS: Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages was used as an in vitro model of inflammation.	Adenosine Triphosphate	58-61	NLR family, pyrin domain containing 3	Mus musculus	71-76
33609086-10	2021	CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation.	3-Hydroxybutyric Acid	33-53	NLR family, pyrin domain containing 3	Mus musculus	115-120
33612104-7	2021	Additionally, imipramine suppressed the LPS/ATP-induced expression of thioredoxin interacting protein (TXNIP), NLRP3, caspase-1, IL-1beta, and IL-18 at the protein and mRNA level.	Imipramine	14-24	NLR family, pyrin domain containing 3	Mus musculus	111-116
33612104-7	2021	Additionally, imipramine suppressed the LPS/ATP-induced expression of thioredoxin interacting protein (TXNIP), NLRP3, caspase-1, IL-1beta, and IL-18 at the protein and mRNA level.	Adenosine Triphosphate	44-47	NLR family, pyrin domain containing 3	Mus musculus	111-116
33612104-8	2021	Interestingly verapamil, a TXNIP inhibitor, suppressed LPS/ATP-induced activation of TXNIP/NLRP3 inflammasome but did not affect LPS/ATP-induced ASM activation and Cer formation.	Verapamil	14-23	NLR family, pyrin domain containing 3	Mus musculus	91-96
33612104-8	2021	Interestingly verapamil, a TXNIP inhibitor, suppressed LPS/ATP-induced activation of TXNIP/NLRP3 inflammasome but did not affect LPS/ATP-induced ASM activation and Cer formation.	Adenosine Triphosphate	59-62	NLR family, pyrin domain containing 3	Mus musculus	91-96
33612104-9	2021	TXNIP siRNA and verapamil inhibited C2-Cer-induced upregulation of TXNIP and activation of the NLRP3 inflammasome.	Verapamil	16-25	NLR family, pyrin domain containing 3	Mus musculus	95-100
33612104-9	2021	TXNIP siRNA and verapamil inhibited C2-Cer-induced upregulation of TXNIP and activation of the NLRP3 inflammasome.	N-acetylsphingosine	36-42	NLR family, pyrin domain containing 3	Mus musculus	95-100
33612104-10	2021	In addition, the pretreatment of cells with sulfo-N-succinimidyl oleate (SSO), an irreversible inhibitor of the scavenger receptor CD36, blocked Cer-induced upregulation of nuclear factor-kappaB (NF-kappaB) activity, TXNIP expression, and NLRP3 inflammasome activation.	sulfo-N-succinimidyl oleate	44-71	NLR family, pyrin domain containing 3	Mus musculus	239-244
33612104-10	2021	In addition, the pretreatment of cells with sulfo-N-succinimidyl oleate (SSO), an irreversible inhibitor of the scavenger receptor CD36, blocked Cer-induced upregulation of nuclear factor-kappaB (NF-kappaB) activity, TXNIP expression, and NLRP3 inflammasome activation.	sulfo-N-succinimidyl oleate	73-76	NLR family, pyrin domain containing 3	Mus musculus	239-244
33612104-10	2021	In addition, the pretreatment of cells with sulfo-N-succinimidyl oleate (SSO), an irreversible inhibitor of the scavenger receptor CD36, blocked Cer-induced upregulation of nuclear factor-kappaB (NF-kappaB) activity, TXNIP expression, and NLRP3 inflammasome activation.	Ceramides	145-148	NLR family, pyrin domain containing 3	Mus musculus	239-244
33612104-11	2021	Inhibition of NF-kappaB activation by SN50 prevented Cer-induced upregulation of TXNIP and activation of the NLRP3 inflammasome but did not affect CD36 expression.	Ceramides	53-56	NLR family, pyrin domain containing 3	Mus musculus	109-114
33612104-13	2021	The results documented that the CD36-dependent NF-kappaB-TXNIP signaling pathway plays an essential role in the Cer-induced activation of NLRP3 inflammasomes in macrophages.	Ceramides	112-115	NLR family, pyrin domain containing 3	Mus musculus	138-143
33609086-1	2021	AIM: This study aimed to assess the response of endogenous beta-hydroxybutyrate to psychological stress, and its association with nucleotide-binding domain, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome, and stress-induced behavior.	3-Hydroxybutyric Acid	59-79	NLR family, pyrin domain containing 3	Mus musculus	205-210
33609086-6	2021	A correlation was found between the increased beta-hydroxybutyrate levels in the blood and the active NLRP3 levels in the prefrontal cortex.	3-Hydroxybutyric Acid	46-66	NLR family, pyrin domain containing 3	Mus musculus	102-107
33609086-10	2021	CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation.	3-Hydroxybutyric Acid	184-204	NLR family, pyrin domain containing 3	Mus musculus	115-120
33579380-0	2021	Low-dose Diosbulbin-B (DB) activates tumor-intrinsic PD-L1/NLRP3 signaling pathway mediated pyroptotic cell death to increase cisplatin-sensitivity in gastric cancer (GC).	diosbulbin B	9-21	NLR family, pyrin domain containing 3	Mus musculus	59-64
33670601-0	2021	Loganin Alleviates Gout Inflammation by Suppressing NLRP3 Inflammasome Activation and Mitochondrial Damage.	loganin	0-7	NLR family, pyrin domain containing 3	Mus musculus	52-57
33670601-2	2021	The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators.	msu	73-76	NLR family, pyrin domain containing 3	Mus musculus	47-52
33670601-2	2021	The etiology of gout is directly linked to the NLRP3 inflammasome, since MSU crystals are NLRP3 inflammasome activators.	msu	73-76	NLR family, pyrin domain containing 3	Mus musculus	90-95
33670601-4	2021	We found that loganin suppressed MSU crystals-induced caspase-1 (p20) and interleukin (IL)-1beta production and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) specks formation in mouse primary macrophages, showing its ability to inhibit the NLRP3 inflammasome.	loganin	14-21	NLR family, pyrin domain containing 3	Mus musculus	280-285
33670601-4	2021	We found that loganin suppressed MSU crystals-induced caspase-1 (p20) and interleukin (IL)-1beta production and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) specks formation in mouse primary macrophages, showing its ability to inhibit the NLRP3 inflammasome.	msu	33-36	NLR family, pyrin domain containing 3	Mus musculus	280-285
33670601-6	2021	Furthermore, oral administration of loganin suppressed MSU crystals-induced gout inflammation in a mouse foot gout model, which was accompanied by the inhibition of the NLRP3 inflammasome.	loganin	36-43	NLR family, pyrin domain containing 3	Mus musculus	169-174
33670601-9	2021	These data demonstrate that loganin suppresses NLRP3 inflammasome activation by inhibiting mitochondrial stress.	loganin	28-35	NLR family, pyrin domain containing 3	Mus musculus	47-52
33643070-2	2021	In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process.	Homocysteine	15-27	NLR family, pyrin domain containing 3	Mus musculus	87-92
33579380-0	2021	Low-dose Diosbulbin-B (DB) activates tumor-intrinsic PD-L1/NLRP3 signaling pathway mediated pyroptotic cell death to increase cisplatin-sensitivity in gastric cancer (GC).	Cisplatin	126-135	NLR family, pyrin domain containing 3	Mus musculus	59-64
33643070-2	2021	In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process.	Homocysteine	29-32	NLR family, pyrin domain containing 3	Mus musculus	87-92
33643070-3	2021	Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo.	Homocysteine	0-3	NLR family, pyrin domain containing 3	Mus musculus	26-31
33579380-9	2021	In addition, low-dose DB triggered cell pyroptosis in CR-GC cells co-treated with cisplatin, which were abrogated by silencing NLRP3.	Cisplatin	82-91	NLR family, pyrin domain containing 3	Mus musculus	127-132
33579380-11	2021	Furthermore, we proved that PD-L1 negatively regulated NLRP3 in CR-GC cells, and low-dose DB activated NLRP3-mediated pyroptotic cell death in cisplatin treated CR-GC cells by downregulating PD-L1.	Cisplatin	143-152	NLR family, pyrin domain containing 3	Mus musculus	103-108
33579380-13	2021	CONCLUSIONS: Collectively, low-dose DB regulated intrinsic PD-L1/NLRP3 pathway to improve cisplatin-sensitivity in CR-GC cells, and this study provided alternative therapy treatments for GC.	Cisplatin	90-99	NLR family, pyrin domain containing 3	Mus musculus	65-70
33573688-0	2021	Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity.	Nigericin	44-53	NLR family, pyrin domain containing 3	Mus musculus	62-67
33573688-13	2021	CONCLUSIONS: Our study reveals that Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity.	Adenosine Triphosphate	73-76	NLR family, pyrin domain containing 3	Mus musculus	98-103
33573688-9	2021	RESULTS: Icariside I specifically enhances NLRP3 inflammasome activation triggered by ATP or nigericin but not SiO2, poly(I:C) or cytosolic LPS.	Adenosine Triphosphate	86-89	NLR family, pyrin domain containing 3	Mus musculus	43-48
33573688-13	2021	CONCLUSIONS: Our study reveals that Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity.	Nigericin	80-89	NLR family, pyrin domain containing 3	Mus musculus	98-103
33573688-9	2021	RESULTS: Icariside I specifically enhances NLRP3 inflammasome activation triggered by ATP or nigericin but not SiO2, poly(I:C) or cytosolic LPS.	Nigericin	93-102	NLR family, pyrin domain containing 3	Mus musculus	43-48
33574236-0	2021	Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3.	withaferin A	0-12	NLR family, pyrin domain containing 3	Mus musculus	72-77
33570219-0	2021	Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation.	Abscisic Acid	0-13	NLR family, pyrin domain containing 3	Mus musculus	43-48
33570219-4	2021	The results showed that ABA effectively stunted the development of airway inflammation, and concordantly downregulated OVA-induced activation of NLRP3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	Abscisic Acid	24-27	NLR family, pyrin domain containing 3	Mus musculus	145-150
33570219-7	2021	Collectively, ABA ameliorates OVA-induced allergic airway inflammation in a PPAR-gamma dependent manner, and such effect of ABA may be associated with its inhibitory effect on NLRP3 inflammasome and oxidative stress.	Abscisic Acid	14-17	NLR family, pyrin domain containing 3	Mus musculus	176-181
33570219-6	2021	Consistently, ABA inhibited the activation of NLRP3 inflammasome, suppressed oxidative stress and mitochondrial fusion/fission in LPS-stimulated Raw264.7 cells via PPAR-gamma.	Abscisic Acid	14-17	NLR family, pyrin domain containing 3	Mus musculus	46-51
33570219-7	2021	Collectively, ABA ameliorates OVA-induced allergic airway inflammation in a PPAR-gamma dependent manner, and such effect of ABA may be associated with its inhibitory effect on NLRP3 inflammasome and oxidative stress.	Abscisic Acid	124-127	NLR family, pyrin domain containing 3	Mus musculus	176-181
33567275-2	2021	Of note, multi-walled carbon nanotubes (MWCNTs), the highly representative products of nanotechnology, induce macrophage NLRP3 inflammasome activation and cause asbestosis-like pathogenesis.	Carbon	22-28	NLR family, pyrin domain containing 3	Mus musculus	121-126
33564842-2	2021	The Omega class glutathione transferase GSTO1-1 regulates the release of the pro-inflammatory cytokines interleukin 1beta (IL-1beta) and interleukin 18 (IL-18) by deglutathionylating NEK7 in the NLRP3 inflammasome.	Glutathione	16-27	NLR family, pyrin domain containing 3	Mus musculus	195-200
33022338-12	2021	Morroniside administration led to inhibition of matrix metalloproteinase-13 (MMP13), Caspase-1 and nod-like receptor protein-3 (NLRP3) expression in DMM mice and IL-1beta-stimulated chondrocytes.	morroniside	0-11	NLR family, pyrin domain containing 3	Mus musculus	99-126
33022338-12	2021	Morroniside administration led to inhibition of matrix metalloproteinase-13 (MMP13), Caspase-1 and nod-like receptor protein-3 (NLRP3) expression in DMM mice and IL-1beta-stimulated chondrocytes.	morroniside	0-11	NLR family, pyrin domain containing 3	Mus musculus	128-133
33614540-9	2020	Results: After acetate treatment, the expression levels of TNF-alpha, IL-1beta, IL-18, NLRP3, and caspase-1 were significantly reduced, while the expression of GPR43 was increased.	Acetates	15-22	NLR family, pyrin domain containing 3	Mus musculus	87-92
33547278-3	2021	We, therefore, hypothesized that the recognition of sUA is achieved by the Naip1-Nlrp3 inflammasome platform.	sua	52-55	NLR family, pyrin domain containing 3	Mus musculus	81-86
33603669-5	2020	Meanwhile, IOP treatment increased in expression of the NLRP3 inflammasome, IL-1beta, and IL-18 in the colon of CAC mice.	Epinephrine	11-14	NLR family, pyrin domain containing 3	Mus musculus	56-61
33614540-0	2020	Acetate Downregulates the Activation of NLRP3 Inflammasomes and Attenuates Lung Injury in Neonatal Mice With Bronchopulmonary Dysplasia.	Acetates	0-7	NLR family, pyrin domain containing 3	Mus musculus	40-45
33475360-0	2021	Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway.	Lycopene	0-8	NLR family, pyrin domain containing 3	Mus musculus	114-119
33475360-0	2021	Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway.	Diethylhexyl Phthalate	21-47	NLR family, pyrin domain containing 3	Mus musculus	114-119
33475360-5	2021	Moreover, the addition of Lyc inhibited DEHP-induced Caspase-1, NLRP3, ASC, NF-kappaB, IL-1beta, and IL-18 overexpression and GSDMD down-expression.	Diethylhexyl Phthalate	40-44	NLR family, pyrin domain containing 3	Mus musculus	64-69
33641782-0	2021	Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-kappaB, NLRP3 pathway.	mangiferin	0-10	NLR family, pyrin domain containing 3	Mus musculus	109-114
32436066-0	2021	Selenium Plays an Anti-Inflammatory Role by Regulation NLRP3 Inflammasome in Staphylococcus aureus-Infected Mouse Mammary Gland.	Selenium	0-8	NLR family, pyrin domain containing 3	Mus musculus	55-60
33358726-3	2021	Increasing evidence shows that the inflammatory response, mediated by activated nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasomes, is associated with the onset and progression of a wide range of diseases of the CNS.	Leucine	124-131	NLR family, pyrin domain containing 3	Mus musculus	176-181
33634989-0	2021	Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway.	Cholecalciferol	0-10	NLR family, pyrin domain containing 3	Mus musculus	91-96
33634989-0	2021	Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway.	Nitrogen	23-31	NLR family, pyrin domain containing 3	Mus musculus	91-96
33634989-8	2021	Mito-TEMPO (a mtROS scavenger) ameliorated NM-caused NLRP3 inflammasome activation in keratinocytes.	MitoTEMPO	0-10	NLR family, pyrin domain containing 3	Mus musculus	53-58
32436066-3	2021	In this experiment, we investigated whether selenium can inhibit the activation of the NLRP3 inflammasome in a mouse model of Staphylococcus aureus-induced mastitis.	Selenium	44-52	NLR family, pyrin domain containing 3	Mus musculus	87-92
32436066-7	2021	Through pathological staining, western blot analysis, real-time fluorescence quantitative polymerase chain reaction analysis, and enzyme-linked immunosorbent assay, the regulation effect of Selenium on NLRP3 inflammasome was detected.	Selenium	190-198	NLR family, pyrin domain containing 3	Mus musculus	202-207
32436066-8	2021	The result showed that compared with the control group, selenium significantly inhibited the expression of NLRP3, ASC, Caspase-1, Caspase-1 p20, and Pro-IL-1beta (p < 0.01).	Selenium	56-64	NLR family, pyrin domain containing 3	Mus musculus	107-112
32436066-10	2021	Therefore, these results suggest that dietary selenium can attenuate Staphylococcus aureus mastitis by inhibition of the NLRP3 inflammasome.	Selenium	46-54	NLR family, pyrin domain containing 3	Mus musculus	121-126
33181270-6	2021	Further, ibrutinib treatment inhibited LPS-activated inflammasome activation by targeting NLRP3/P38/Caspase-1 signaling.	ibrutinib	9-18	NLR family, pyrin domain containing 3	Mus musculus	90-95
33641782-10	2021	The results showed that mangiferin treatment significantly reduced NO, IL-1beta, IL-6 and TNF-alpha production, also reduced the mRNA and protein of iNOS and COX-2, promoted the polarization of inflammatory toward anti-inflammatory, and inhibited activation of NF-kappaB and NLRP3 inflammasome.	mangiferin	24-34	NLR family, pyrin domain containing 3	Mus musculus	275-280
33641782-11	2021	These data suggest that mangiferin has an anti-neuroinflammatory property via regulating microglia macrophage polarization and suppressing NF-kappaB and NLRP3 signaling pathway, and may act as a potential natural therapeutic candidate for neuroinflammatory diseases.	mangiferin	24-34	NLR family, pyrin domain containing 3	Mus musculus	153-158
33359024-0	2021	Chronic Oral Exposure to Cadmium Causes Liver Inflammation by NLRP3 Inflammasome Activation in Pubertal Mice.	Cadmium	25-32	NLR family, pyrin domain containing 3	Mus musculus	62-67
33359024-7	2021	Most importantly, the data validated a pivotal role of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome in Cd-induced inflammation in liver at puberty.	Cadmium	123-125	NLR family, pyrin domain containing 3	Mus musculus	100-105
33359024-8	2021	Collectively, our results suggested that low-dose Cd oral exposure can cause liver inflammation via activation of NLRP3 inflammasome and give rise to severe liver injury at puberty.	Cadmium	50-52	NLR family, pyrin domain containing 3	Mus musculus	114-119
32936353-0	2021	Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	104-109
33613874-7	2021	H-VLNs impede the formation and activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome, which is a crucial inflammatory signalling platform in the innate immune system.	h-vlns	0-6	NLR family, pyrin domain containing 3	Mus musculus	80-147
33613874-7	2021	H-VLNs impede the formation and activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome, which is a crucial inflammatory signalling platform in the innate immune system.	h-vlns	0-6	NLR family, pyrin domain containing 3	Mus musculus	149-154
33613874-9	2021	miR-4057 in H-VLNs was identified in inhibiting NLRP3 inflammasome activation.	mir-4057	0-8	NLR family, pyrin domain containing 3	Mus musculus	48-53
32812186-0	2021	Sinomenine Alleviates Murine Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis through Inhibiting NLRP3 Inflammasome.	sinomenine	0-10	NLR family, pyrin domain containing 3	Mus musculus	118-123
32812186-6	2021	In addition, sinomenine successfully attenuated tissue levels of inflammasome NLRP3, ASC, and caspase 1 besides its reduction of intensity of neuroinflammation, demyelination, and axonal damage and loss in lumbar spinal cord specimens.	sinomenine	13-23	NLR family, pyrin domain containing 3	Mus musculus	78-83
33388881-2	2021	However, whether sphingosine 1-phosphate (S1P) plays a role in NLRP3 inflammasome priming and activation remains unknown.	sphingosine 1-phosphate	17-40	NLR family, pyrin domain containing 3	Mus musculus	63-68
33388881-2	2021	However, whether sphingosine 1-phosphate (S1P) plays a role in NLRP3 inflammasome priming and activation remains unknown.	sphingosine 1-phosphate	42-45	NLR family, pyrin domain containing 3	Mus musculus	63-68
33388881-7	2021	Moreover, JTE-013 (S1PR2 inhibitor) treatment markedly reduced NLRP3 inflammasome priming and activation in BDL-injured liver.	JTE 013	10-17	NLR family, pyrin domain containing 3	Mus musculus	63-68
33526073-11	2021	Further molecular mechanisms underlying HDAC1 were explored with NH125, an eEF2K inhibitor, whose treatment reduced immobility time, altered pro-inflammatory cytokines, and NLRP3 expression.	NH 125	65-70	NLR family, pyrin domain containing 3	Mus musculus	173-178
33259938-0	2021	Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway.	Cisplatin	24-33	NLR family, pyrin domain containing 3	Mus musculus	65-70
33259938-4	2021	Our results showed that in wide type mice, renal function loss, tissue injury and cell death induced by cisplatin were alleviated by pretreatment of high-dose paricalcitol(a VDR agonist) accompanied with up-regulated VDR and decreased expression of NLRP3, GSDMD-N, Cleaved-Caspase-1 and mature Interleukin- 1beta (features of pyroptosis).	Cisplatin	104-113	NLR family, pyrin domain containing 3	Mus musculus	249-254
33259938-4	2021	Our results showed that in wide type mice, renal function loss, tissue injury and cell death induced by cisplatin were alleviated by pretreatment of high-dose paricalcitol(a VDR agonist) accompanied with up-regulated VDR and decreased expression of NLRP3, GSDMD-N, Cleaved-Caspase-1 and mature Interleukin- 1beta (features of pyroptosis).	paricalcitol	159-171	NLR family, pyrin domain containing 3	Mus musculus	249-254
33522199-0	2021	Qingre Jianpi decoction attenuates inflammatory responses by suppressing NOD-like receptor family pyrin domain-containing 3 inflammasome activation in dextran sulfate sodium-induced colitis mice.	Dextran Sulfate	151-173	NLR family, pyrin domain containing 3	Mus musculus	73-123
33522199-6	2021	RESULTS: QRJPD played an anti-inflammatory role in the treatment of ulcerative colitis (UC), reduced the secretion of inflammatory cytokines, and inhibited the inflammatory infiltration of immune cells by suppressing DSS-induced activation of the NLRP3 inflammasome.	Dextran Sulfate	217-220	NLR family, pyrin domain containing 3	Mus musculus	247-252
33522199-7	2021	CONCLUSION: QRJPD exerts protective effects by inhibiting DSS-induced NLRP3 inflammasome activation.	Dextran Sulfate	58-61	NLR family, pyrin domain containing 3	Mus musculus	70-75
33108630-5	2021	The in vitro study performed on BV2 cells indicated that betaOHB inhibited an LPS+ATP-induced inflammatory response and decreased NLRP3 protein levels.	betaohb	57-64	NLR family, pyrin domain containing 3	Mus musculus	130-135
33025508-5	2021	We further demonstrated that PF administration inhibited the enhanced expression of GSDMD which mainly distributed in microglia, along with the proteins involved in pyroptosis signaling transduction including caspase (CASP)-11, CASP-1, NLRP3, and interleukin (IL)-1beta in the hippocampus of mice treated with reserpine.	peoniflorin	29-31	NLR family, pyrin domain containing 3	Mus musculus	236-241
33025508-6	2021	And also, PF prevented lipopolysaccharide (LPS) and adenosine triphosphate (ATP)-induced pyroptosis in murine N9 microglia in vitro, evidenced by inhibiting the expression of CASP-11, NLRP3, CASP-1 cleavage, as well as IL-1beta.	peoniflorin	10-12	NLR family, pyrin domain containing 3	Mus musculus	184-189
32936353-1	2021	Melatonin improved the outcome of septic cardiomyopathy by inhibiting NLRP3 priming induced by reactive oxygen species.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
32936353-1	2021	Melatonin improved the outcome of septic cardiomyopathy by inhibiting NLRP3 priming induced by reactive oxygen species.	Oxygen	104-110	NLR family, pyrin domain containing 3	Mus musculus	70-75
32936353-9	2021	In turn, melatonin further enhanced the Nrf2 response in both mice strains and reduced the NLRP3 inflammasome activation in nlrp3+/+ mice, restoring myocardial homeostasis.	Melatonin	9-18	NLR family, pyrin domain containing 3	Mus musculus	91-96
32936353-9	2021	In turn, melatonin further enhanced the Nrf2 response in both mice strains and reduced the NLRP3 inflammasome activation in nlrp3+/+ mice, restoring myocardial homeostasis.	Melatonin	9-18	NLR family, pyrin domain containing 3	Mus musculus	124-129
33352229-5	2021	In vivo, cryptotanshinone attenuates caspase-1 activation and IL-1beta secretion in mouse models of NLRP3 inflammasome-mediated diseases such as endotoxemia syndrome and methionine- and choline-deficient-diet-induced nonalcoholic steatohepatitis (NASH).	cryptotanshinone	9-25	NLR family, pyrin domain containing 3	Mus musculus	100-105
33352229-0	2021	Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases.	cryptotanshinone	0-16	NLR family, pyrin domain containing 3	Mus musculus	41-46
33352229-6	2021	Our findings suggest that cryptotanshinone may be a promising therapeutic agent for the treatment of NLRP3 inflammasome-mediated diseases.	cryptotanshinone	26-42	NLR family, pyrin domain containing 3	Mus musculus	101-106
33352229-2	2021	Here, we demonstrate that cryptotanshinone (CTS), a major component derived from the traditional medicinal herb Salvia miltiorrhiza Bunge, is a specific inhibitor for the NLRP3 inflammasome.	cryptotanshinone	26-42	NLR family, pyrin domain containing 3	Mus musculus	171-176
32769820-0	2021	Aluminum Adjuvant Improves Survival via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis.	aluminum adjuvant	0-17	NLR family, pyrin domain containing 3	Mus musculus	40-45
33352229-2	2021	Here, we demonstrate that cryptotanshinone (CTS), a major component derived from the traditional medicinal herb Salvia miltiorrhiza Bunge, is a specific inhibitor for the NLRP3 inflammasome.	cryptotanshinone	44-47	NLR family, pyrin domain containing 3	Mus musculus	171-176
33352229-3	2021	Cryptotanshinone inhibits NLRP3 inflammasome activation in macrophages, but has no effects on AIM2 or NLRC4 inflammasome activation.	cryptotanshinone	0-16	NLR family, pyrin domain containing 3	Mus musculus	26-31
33352229-4	2021	Mechanistically, cryptotanshinone blocks Ca2+ signaling and the induction of mitochondrial reactive oxygen species (mtROS), which are important upstream signals of NLRP3 inflammasome activation.	cryptotanshinone	17-33	NLR family, pyrin domain containing 3	Mus musculus	164-169
33352229-4	2021	Mechanistically, cryptotanshinone blocks Ca2+ signaling and the induction of mitochondrial reactive oxygen species (mtROS), which are important upstream signals of NLRP3 inflammasome activation.	Reactive Oxygen Species	91-114	NLR family, pyrin domain containing 3	Mus musculus	164-169
32893437-0	2021	Lychee seed polyphenol protects the blood-brain barrier through inhibiting Abeta(25-35)-induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1-mediated autophagy in bEnd.3 cells and APP/PS1 mice.	Polyphenols	12-22	NLR family, pyrin domain containing 3	Mus musculus	96-101
33352465-0	2021	A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity.	nitroalkene	8-19	NLR family, pyrin domain containing 3	Mus musculus	52-57
33352465-0	2021	A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity.	Vitamin E	20-29	NLR family, pyrin domain containing 3	Mus musculus	52-57
33352465-9	2021	In conclusion, we propose that this novel nitroalkene-Trolox derivative is a suitable tool to tackle acute and chronic inflammation in vitro and in vivo mainly due to inhibition of NF-kB/NLRP3 activation.	nitroalkene	42-53	NLR family, pyrin domain containing 3	Mus musculus	187-192
33352465-9	2021	In conclusion, we propose that this novel nitroalkene-Trolox derivative is a suitable tool to tackle acute and chronic inflammation in vitro and in vivo mainly due to inhibition of NF-kB/NLRP3 activation.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	54-60	NLR family, pyrin domain containing 3	Mus musculus	187-192
32769820-6	2021	Utilizing genetic and cell-depletion studies, we demonstrate here that the prophylactic administration of aluminum adjuvants in neonatal mice improves sepsis survival via activation of the NLRP3 inflammasome and dendritic cell activation.	aluminum adjuvants	106-124	NLR family, pyrin domain containing 3	Mus musculus	189-194
33427450-0	2021	Limonin Attenuates LPS-Induced Hepatotoxicity by Inhibiting Pyroptosis via NLRP3/Gasdermin D Signaling Pathway.	limonin	0-7	NLR family, pyrin domain containing 3	Mus musculus	75-80
33584302-0	2020	Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson"s Disease Model.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	27-32
33584302-3	2020	However, the effect of Berberine on NLRP3 inflammasome in PD and its potential mechanisms remain unclear.	Berberine	23-32	NLR family, pyrin domain containing 3	Mus musculus	36-41
33058999-9	2021	Additionally, PCN-224 induced cytotoxicity in RAW264.7 cells and increased the protein levels of the inflammasome component NLR Family Pyrin Domain Containing 3 (NLRP3) molecular, which indicated its cellular effects in different cell types.	pcn-224	14-21	NLR family, pyrin domain containing 3	Mus musculus	124-160
33058999-9	2021	Additionally, PCN-224 induced cytotoxicity in RAW264.7 cells and increased the protein levels of the inflammasome component NLR Family Pyrin Domain Containing 3 (NLRP3) molecular, which indicated its cellular effects in different cell types.	pcn-224	14-21	NLR family, pyrin domain containing 3	Mus musculus	162-167
33509753-13	2021	CONCLUSIONS: Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-kappaB/NLRP3 signaling.	ros	132-135	NLR family, pyrin domain containing 3	Mus musculus	146-151
33615201-3	2021	Herein, we examined whether Treg-of-B cells could regulate macrophage function and prevent NLRP3-associated diseases, particularly inflammatory gouty arthritis.	treg	28-32	NLR family, pyrin domain containing 3	Mus musculus	91-96
33615201-4	2021	Treg-of-B cells, but not thymus-derived Treg or effector T cells, inhibited inflammasome-mediated IL-1beta secretion, caspase-1 activation, and NLRP3 production by LPS/ATP stimulation in a cell contact-dependent manner.	Adenosine Triphosphate	168-171	NLR family, pyrin domain containing 3	Mus musculus	144-149
33615201-5	2021	In addition, Treg-of-B cells inhibited monosodium urate-induced NLRP3 inflammasome activation in vitro via NF-kappaB signaling.	Uric Acid	39-55	NLR family, pyrin domain containing 3	Mus musculus	64-69
33584302-7	2020	In our in vivo studies, compared to MPTP group, mice in MPTP + BBR group showed significant amelioration of behavioral disorders, mitigation of neurotoxicity and NLRP3-associated neuroinflammation, enhancement of the autophagic process in substantia nigra (SN).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	56-60	NLR family, pyrin domain containing 3	Mus musculus	162-167
33584302-7	2020	In our in vivo studies, compared to MPTP group, mice in MPTP + BBR group showed significant amelioration of behavioral disorders, mitigation of neurotoxicity and NLRP3-associated neuroinflammation, enhancement of the autophagic process in substantia nigra (SN).	Berberine	63-66	NLR family, pyrin domain containing 3	Mus musculus	162-167
33427450-9	2021	We further demonstrated that limonin ameliorated LPS-induced hepatotoxicity by inhibiting pyroptosis via the NLRP3/gasdermin D signaling pathway.	limonin	29-36	NLR family, pyrin domain containing 3	Mus musculus	109-114
33530569-0	2021	Anti-Inflammatory Effects of Rosmarinic Acid-Loaded Nanovesicles in Acute Colitis through Modulation of NLRP3 Inflammasome.	rosmarinic acid	29-44	NLR family, pyrin domain containing 3	Mus musculus	104-109
33530569-6	2021	Moreover, RA-loaded nanovesicles downregulated protein expression of inflammasome components such as NLR family pyrin domain-containing 3 (NLRP3), adaptor protein (ASC) and caspase-1, and the consequent reduction of IL-1beta levels.	rosmarinic acid	10-12	NLR family, pyrin domain containing 3	Mus musculus	101-137
33530569-6	2021	Moreover, RA-loaded nanovesicles downregulated protein expression of inflammasome components such as NLR family pyrin domain-containing 3 (NLRP3), adaptor protein (ASC) and caspase-1, and the consequent reduction of IL-1beta levels.	rosmarinic acid	10-12	NLR family, pyrin domain containing 3	Mus musculus	139-144
33628094-10	2021	The enhancement of G-Rg1 promoted-autophagy resulted in the significant decrease in NF-kappaB, NLRP3 inflammasome, caspase 1, caspase 3, IL-1beta and IL-18, which suggesting that NF-kappaB/NLRP3 inflammasome signaling pathway was associated with the autophagy induced by G-Rg1 in acute liver injury.	ginsenoside Rg1	19-24	NLR family, pyrin domain containing 3	Mus musculus	95-100
33350984-0	2021	Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.	echinatin	0-9	NLR family, pyrin domain containing 3	Mus musculus	39-44
33350984-2	2021	In this study, we showed that echinatin, the ingredient of the traditional herbal medicine licorice, effectively suppresses the activation of NLRP3 inflammasome in vitro and in vivo.	echinatin	30-39	NLR family, pyrin domain containing 3	Mus musculus	142-147
33350984-3	2021	Further investigation revealed that echinatin exerts its inhibitory effect on NLRP3 inflammasome by binding to heat-shock protein 90 (HSP90), inhibiting its ATPase activity, and disrupting the association between the cochaperone SGT1 and HSP90-NLRP3.	echinatin	36-45	NLR family, pyrin domain containing 3	Mus musculus	78-83
33350984-3	2021	Further investigation revealed that echinatin exerts its inhibitory effect on NLRP3 inflammasome by binding to heat-shock protein 90 (HSP90), inhibiting its ATPase activity, and disrupting the association between the cochaperone SGT1 and HSP90-NLRP3.	echinatin	36-45	NLR family, pyrin domain containing 3	Mus musculus	244-249
33350984-4	2021	Importantly, in vivo experiments demonstrated that administration of echinatin obviously inhibits NLRP3 inflammasome activation and ameliorates LPS-induced septic shock and DSS-induced colitis in mice.	echinatin	69-78	NLR family, pyrin domain containing 3	Mus musculus	98-103
33350984-6	2021	Collectively, our study identified echinatin as a novel inhibitor of NLRP3 inflammasome and may be developed as a potentially therapeutic approach for the treatment of NLRP3-driven diseases.	echinatin	35-44	NLR family, pyrin domain containing 3	Mus musculus	69-74
33350984-6	2021	Collectively, our study identified echinatin as a novel inhibitor of NLRP3 inflammasome and may be developed as a potentially therapeutic approach for the treatment of NLRP3-driven diseases.	echinatin	35-44	NLR family, pyrin domain containing 3	Mus musculus	168-173
33338087-0	2021	Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	66-71
33338087-7	2021	Current data indicated that quercetin might improve neuroinflammation in aging mice by regulating the Sirtuin1/NLRP3 pathway.	Quercetin	28-37	NLR family, pyrin domain containing 3	Mus musculus	111-116
33552083-7	2020	When the WT mice were pretreated with the Nlrp3 inhibitors, both the biochemical indices and survival were significantly improved compared to those without inhibitor pretreatment, with Oridonin being most potent.	oridonin	185-193	NLR family, pyrin domain containing 3	Mus musculus	42-47
33552083-8	2020	Conclusion: Nlrp3 inflammasome activation plays a vital role in the HUS development when mice are challenged by Stx2, and Oridonin is effective in preventing HUS.	oridonin	122-130	NLR family, pyrin domain containing 3	Mus musculus	12-17
33613696-0	2021	Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine.	Methotrexate	0-12	NLR family, pyrin domain containing 3	Mus musculus	107-112
33628094-10	2021	The enhancement of G-Rg1 promoted-autophagy resulted in the significant decrease in NF-kappaB, NLRP3 inflammasome, caspase 1, caspase 3, IL-1beta and IL-18, which suggesting that NF-kappaB/NLRP3 inflammasome signaling pathway was associated with the autophagy induced by G-Rg1 in acute liver injury.	ginsenoside Rg1	19-24	NLR family, pyrin domain containing 3	Mus musculus	189-194
33628094-11	2021	Conclusion: G-Rg1 ameliorated acute liver injury via the autophagy, which may be related to NF-kappaB/NLRP3 inflammasome signaling pathway.	ginsenoside Rg1	12-17	NLR family, pyrin domain containing 3	Mus musculus	102-107
33462188-0	2021	Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson"s disease.	Copper	50-56	NLR family, pyrin domain containing 3	Mus musculus	11-16
33536915-12	2020	Together, these findings demonstrated that OEA protect against the LPS/D-Gal-induced acute liver injury in mice through the inhibition of apoptosis, oxidative stress and inflammation, and its mechanisms might be associated with the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways.	oleoylethanolamide	43-46	NLR family, pyrin domain containing 3	Mus musculus	247-252
33462188-5	2021	In this study, we investigated how the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome contributes to copper-mediated neuroinflammation in an animal model of WD.	Copper	126-132	NLR family, pyrin domain containing 3	Mus musculus	53-89
33462188-5	2021	In this study, we investigated how the activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome contributes to copper-mediated neuroinflammation in an animal model of WD.	Copper	126-132	NLR family, pyrin domain containing 3	Mus musculus	91-96
33462188-9	2021	Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta.	cupric chloride	94-99	NLR family, pyrin domain containing 3	Mus musculus	31-36
33462188-11	2021	Overall, our study demonstrates the contribution of copper overload-mediated activation of NLRP3 inflammasome to progressive neuropathology in the CNS of a murine model of WD.	Copper	52-58	NLR family, pyrin domain containing 3	Mus musculus	91-96
33536915-0	2020	Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.	oleoylethanolamide	0-18	NLR family, pyrin domain containing 3	Mus musculus	84-89
33542692-0	2020	Koumine Suppresses IL-1beta Secretion and Attenuates Inflammation Associated With Blocking ROS/NF-kappaB/NLRP3 Axis in Macrophages.	koumine	0-7	NLR family, pyrin domain containing 3	Mus musculus	105-110
33536915-12	2020	Together, these findings demonstrated that OEA protect against the LPS/D-Gal-induced acute liver injury in mice through the inhibition of apoptosis, oxidative stress and inflammation, and its mechanisms might be associated with the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways.	Galactose	71-76	NLR family, pyrin domain containing 3	Mus musculus	247-252
33542692-1	2020	Koumine (KM), one of the primary constituents of Gelsemium elegans, has been used for the treatment of inflammatory diseases such as rheumatoid arthritis, but whether KM impacts the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome remains unknown.	koumine	0-7	NLR family, pyrin domain containing 3	Mus musculus	229-234
33542692-3	2020	We found that KM dose-dependently inhibited IL-1beta secretion in macrophages after NLRP3 inflammasome activators stimulation.	koumine	14-16	NLR family, pyrin domain containing 3	Mus musculus	84-89
33542692-11	2020	Our results provide the first indication that KM exerts an inhibitory effect on NLRP3 inflammasome activation associated with blocking the ROS/NF-kappaB/NLRP3 signal axis.	Reactive Oxygen Species	139-142	NLR family, pyrin domain containing 3	Mus musculus	80-85
33309808-7	2021	RESULTS: Here, we found that the mRNA and protein levels of NEK7 and NLRP3 inflammasomes were upregulated in spinal cord tissues of injured mice and BV-2 microglia cells exposed to Lipopolysaccharide (LPS) and Adenosine triphosphate (ATP).	Adenosine	210-219	NLR family, pyrin domain containing 3	Mus musculus	69-74
33477467-8	2021	Furthermore, the macrophages of NLRP3-/- mice stimulated with rTSST-1+ATP showed significantly low levels of IL-1beta production compared to that of wild-type mice.	Adenosine Triphosphate	70-73	NLR family, pyrin domain containing 3	Mus musculus	32-37
33039874-9	2021	However, pretreatment with recombinant protein sCD59-Cys inhibited the expression of C5b-9, NLRP3 inflammasome, IL-1beta, IL-18, and attenuated renal tubular epithelial cell damage.	scd59-cys	47-56	NLR family, pyrin domain containing 3	Mus musculus	92-97
33039874-11	2021	Pretreatment with recombinant protein sCD59-Cys blocked the expression of the NLRP3 inflammasome by inhibiting the expression of C5b-9, and alleviating renal tubular epithelial cell damage.	scd59-cys	38-47	NLR family, pyrin domain containing 3	Mus musculus	78-83
33399849-5	2021	Macrophages from STZ-induced T1D mice exhibited increased inflammatory cytokine/chemokine levels, nitric oxide (NO) secretion, NLRP3 and iNOS protein levels, and augmented glycolytic activity compared to control animals.	Streptozocin	17-20	NLR family, pyrin domain containing 3	Mus musculus	127-132
33039874-0	2021	C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice.	Trichloroethylene	99-116	NLR family, pyrin domain containing 3	Mus musculus	40-45
33039874-3	2021	This study aimed to investigate whether TCE-sensitized mouse renal tubular epithelial cell damage was induced by NLRP3 inflammasome and whether NLRP3 inflammasome was activated by sublytic C5b-9.	Trichloroethylene	40-43	NLR family, pyrin domain containing 3	Mus musculus	113-118
33039874-8	2021	The renal lesions, serum NGAL level, renal NLRP3, ASC, Caspase-1 and IL-1beta protein levels all increased significantly in TCE sensitized positive group.	Trichloroethylene	124-127	NLR family, pyrin domain containing 3	Mus musculus	43-48
33309808-7	2021	RESULTS: Here, we found that the mRNA and protein levels of NEK7 and NLRP3 inflammasomes were upregulated in spinal cord tissues of injured mice and BV-2 microglia cells exposed to Lipopolysaccharide (LPS) and Adenosine triphosphate (ATP).	Adenosine Triphosphate	234-237	NLR family, pyrin domain containing 3	Mus musculus	69-74
33275990-9	2021	KEY FINDINGS: After treatment with MTDs the expression levels of inflammatory cytokines and NLRP3 inflammasome-associated proteins were gradually increased in vitro and in vivo.	mtds	35-39	NLR family, pyrin domain containing 3	Mus musculus	92-97
33440601-5	2021	Ac2-26 administration reduced NLRP3-derived IL-1beta production by WT neutrophils after nigericin and ATP stimulation.	annexin A1 peptide (2-26)	0-6	NLR family, pyrin domain containing 3	Mus musculus	30-35
33436548-0	2021	Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation.	Rosuvastatin Calcium	0-12	NLR family, pyrin domain containing 3	Mus musculus	95-100
33332136-0	2021	Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis.	1,2,3,4-tetrahydroquinoline	21-40	NLR family, pyrin domain containing 3	Mus musculus	55-60
33332136-0	2021	Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis.	Dextran Sulfate	101-104	NLR family, pyrin domain containing 3	Mus musculus	55-60
33332136-7	2021	Furthermore, in the dextran sulfate sodium (DSS)-induced colitis mouse model, compound 6 exhibited significant anti-inflammatory activity through inhibiting NLRP3 inflammasome in vivo.	Dextran Sulfate	20-42	NLR family, pyrin domain containing 3	Mus musculus	157-162
33332136-7	2021	Furthermore, in the dextran sulfate sodium (DSS)-induced colitis mouse model, compound 6 exhibited significant anti-inflammatory activity through inhibiting NLRP3 inflammasome in vivo.	Dextran Sulfate	44-47	NLR family, pyrin domain containing 3	Mus musculus	157-162
33446652-3	2021	The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1beta upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice.	flavanol	19-27	NLR family, pyrin domain containing 3	Mus musculus	178-183
33441763-4	2021	Both mechanical HIFU and thermal ablation induced a potent inflammatory response with increased expression of Nlrp3, Jun, Mefv, Il6 and Il1beta and alterations in macrophage polarization compared to control.	hifu	16-20	NLR family, pyrin domain containing 3	Mus musculus	110-115
33441763-5	2021	Furthermore, HIFU upregulated multiple innate immune receptors and immune pathways, including Nod1, Nlrp3, Aim2, Ctsb, Tlr1/2/4/7/8/9, Oas2, and RhoA.	hifu	13-17	NLR family, pyrin domain containing 3	Mus musculus	100-105
33440601-5	2021	Ac2-26 administration reduced NLRP3-derived IL-1beta production by WT neutrophils after nigericin and ATP stimulation.	Nigericin	88-97	NLR family, pyrin domain containing 3	Mus musculus	30-35
33440601-5	2021	Ac2-26 administration reduced NLRP3-derived IL-1beta production by WT neutrophils after nigericin and ATP stimulation.	Adenosine Triphosphate	102-105	NLR family, pyrin domain containing 3	Mus musculus	30-35
33413632-7	2021	MSC-derived PGE2 inhibited TGF-beta-activated kinase 1 (TAK1) signaling and NLRP3 inflammasome activation in liver macrophages to decrease the production of inflammatory cytokines.	Dinoprostone	12-16	NLR family, pyrin domain containing 3	Mus musculus	76-81
33295913-0	2021	High n-3 fatty acids counteract hyperglycemia-induced insulin resistance in fat-1 mice via pre-adipocyte NLRP3 inflammasome inhibition.	Fatty Acids, Omega-3	5-20	NLR family, pyrin domain containing 3	Mus musculus	105-110
33295913-3	2021	Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues.	Fatty Acids, Omega-3	11-20	NLR family, pyrin domain containing 3	Mus musculus	166-171
33295913-3	2021	Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues.	Glucose	78-85	NLR family, pyrin domain containing 3	Mus musculus	166-171
33295913-3	2021	Endogenous n-3 PUFAs in fat-1 mice were found to impair hyperglycemia or high glucose level-induced nucleotide-binding domain and leucine-rich repeat pyrin 3 domain (NLRP3) inflammasome activation and inhibit IL-1beta secretion in adipose tissues.	Leucine	130-137	NLR family, pyrin domain containing 3	Mus musculus	166-171
33295913-5	2021	Furthermore, in 3T3-L1 pre-adipocytes, high levels of glucose induced thioredoxin interacting protein (TXNIP) expression and activated the NLRP3 inflammasome, which was counteracted by docosahexaenoic acid (DHA), the major n-3 PUFA in fat-1 mice, by downregulating TXNIP via the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.	Glucose	54-61	NLR family, pyrin domain containing 3	Mus musculus	139-144
33295913-5	2021	Furthermore, in 3T3-L1 pre-adipocytes, high levels of glucose induced thioredoxin interacting protein (TXNIP) expression and activated the NLRP3 inflammasome, which was counteracted by docosahexaenoic acid (DHA), the major n-3 PUFA in fat-1 mice, by downregulating TXNIP via the phosphatidylinositol-3-kinase (PI3K)/Akt pathway.	Docosahexaenoic Acids	185-205	NLR family, pyrin domain containing 3	Mus musculus	139-144
33078829-0	2021	Microcystin-LR induces NLRP3 inflammasome activation via FOXO1 phosphorylation, resulting in interleukin-1beta secretion and pyroptosis in hepatocytes.	cyanoginosin LR	0-14	NLR family, pyrin domain containing 3	Mus musculus	23-28
33078829-3	2021	In this study, we investigated the possible role of NLRP3 inflammasome activation in MC-LR-induced mouse liver inflammatory injury.	cyanoginosin LR	85-90	NLR family, pyrin domain containing 3	Mus musculus	52-57
33078829-7	2021	In addition, we found that inhibition of FOXO1 by AKT-mediated hyperphosphorylation, due to PP2A inhibition, is required for MC-LR-induced expression of NLRP3.	cyanoginosin LR	125-130	NLR family, pyrin domain containing 3	Mus musculus	153-158
33078829-8	2021	Taken together, our in vivo and in vitro findings suggest a model in which the NLRP3 inflammasome activation, a result of AKT-mediated hyperphosphorylation of FOXO1 through inhibition of PP2A, plays a key role in MC-LR-induced liver inflammatory injury via IL-1beta secretion and pyroptotic cell death.	cyanoginosin LR	213-218	NLR family, pyrin domain containing 3	Mus musculus	79-84
33078829-4	2021	We found that MC-LR administered to mice by oral gavage mainly accumulated in liver and induced the activation of the NLRP3 inflammasome and production of mature IL-1beta.	cyanoginosin LR	14-19	NLR family, pyrin domain containing 3	Mus musculus	118-123
33078829-5	2021	Additionally, we observed an increase in the levels of NLRP3 inflammasome-related proteins and the proportion of pyroptosis in MC-LR-treated AML-12 cells.	aml-12	141-147	NLR family, pyrin domain containing 3	Mus musculus	55-60
33078829-6	2021	We also found that inhibition of NLRP3 in mice attenuated MC-LR-induced IL-1beta production, indicating an essential role for NLRP3 in MC-LR-induced liver inflammatory injury.	cyanoginosin LR	58-63	NLR family, pyrin domain containing 3	Mus musculus	33-38
33078829-6	2021	We also found that inhibition of NLRP3 in mice attenuated MC-LR-induced IL-1beta production, indicating an essential role for NLRP3 in MC-LR-induced liver inflammatory injury.	cyanoginosin LR	135-140	NLR family, pyrin domain containing 3	Mus musculus	33-38
33078829-6	2021	We also found that inhibition of NLRP3 in mice attenuated MC-LR-induced IL-1beta production, indicating an essential role for NLRP3 in MC-LR-induced liver inflammatory injury.	cyanoginosin LR	135-140	NLR family, pyrin domain containing 3	Mus musculus	126-131
33213837-0	2021	NLRP3 inflammasome inhibitor CY-09 reduces hepatic steatosis in experimental NAFLD mice.	CY5.5 cyanine dye	29-34	NLR family, pyrin domain containing 3	Mus musculus	0-5
32998520-4	2021	P2X7 is a ligand-gated cation channel that is activated in response to high concentrations of extracellular ATP, triggering the assembly and activation of the NLRP3 (nuclear oligomerization domain like receptor family pyrin domain containing 3) inflammasome and subsequent release of proinflammatory cytokines IL (interleukin)-1beta and IL-18.	Adenosine Triphosphate	108-111	NLR family, pyrin domain containing 3	Mus musculus	159-164
33490276-13	2021	In addition, high concentration of KCl significantly inhibited the effect of LpqH on mouse Ana-1 macrophages and reduced the expression of NLRP3, ASC, and caspase-1 p20 (P < 0.01).	Potassium Chloride	35-38	NLR family, pyrin domain containing 3	Mus musculus	139-144
33490276-16	2021	LpqH protein has good immunogenicity and can activate the NLRP3 inflammasome through the potassium efflux pathway without causing cell death.	Potassium	89-98	NLR family, pyrin domain containing 3	Mus musculus	58-63
33220928-0	2021	Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	NLR family, pyrin domain containing 3	Mus musculus	65-70
33220928-0	2021	Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.	Folic Acid	100-110	NLR family, pyrin domain containing 3	Mus musculus	65-70
33213837-3	2021	A small-molecule named CY-09 is a new selective and direct inhibitor of the NLRP3 inflammasome.	CY5.5 cyanine dye	23-28	NLR family, pyrin domain containing 3	Mus musculus	76-81
33272570-0	2021	Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome.	baicalein	0-9	NLR family, pyrin domain containing 3	Mus musculus	52-57
33220928-8	2021	In conclusion, this study demonstrated that AKF-PD inhibited renal fibrosis by suppressing the mtROS-NLRP3 pathway in the folic acid nephropathy model.	Folic Acid	122-132	NLR family, pyrin domain containing 3	Mus musculus	101-106
33232925-0	2021	Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis pathway.	Uric Acid	0-9	NLR family, pyrin domain containing 3	Mus musculus	68-73
33321327-0	2021	Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-kappaB/NLRP3 pathway.	Nicotine	27-35	NLR family, pyrin domain containing 3	Mus musculus	80-85
33321327-8	2021	Nicotine promoted pyroptosis in RAW264.7 cells, as evidenced by increased expression of cleaved Caspase1, NLRP3, IL-1beta, IL-18, and elevated LDH release.	Nicotine	0-8	NLR family, pyrin domain containing 3	Mus musculus	106-111
33321327-9	2021	Inhibition of HDAC6 suppressed nicotine-induced pyroptosis, which is partly mediated by p65 acetylation and NLRP3 transcription.	Nicotine	31-39	NLR family, pyrin domain containing 3	Mus musculus	108-113
33321327-11	2021	CONCLUSIONS: Nicotine induces macrophage pyroptosis in atherosclerosis through HDAC6/NF-kappaB/NLRP3 signaling pathway.	Nicotine	13-21	NLR family, pyrin domain containing 3	Mus musculus	95-100
33260093-0	2021	A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration.	Dopamine	2-10	NLR family, pyrin domain containing 3	Mus musculus	115-120
33272570-5	2021	Using a cytometric bead array, we found that IL-1alpha and IL-1beta, the downstream of NLRP3, had highest reduction among the plasma inflammatory cytokines in LPS/D-Gal-challenged mice after a treatment of baicalein.	Galactose	163-168	NLR family, pyrin domain containing 3	Mus musculus	87-92
33272570-5	2021	Using a cytometric bead array, we found that IL-1alpha and IL-1beta, the downstream of NLRP3, had highest reduction among the plasma inflammatory cytokines in LPS/D-Gal-challenged mice after a treatment of baicalein.	baicalein	206-215	NLR family, pyrin domain containing 3	Mus musculus	87-92
33272570-7	2021	Deficiency of Nlrp3 or Gsdmd significantly restored LPS/D-Gal-induced acute liver injury and lethality, and further administration of baicalein did not have additive effects.	Galactose	56-61	NLR family, pyrin domain containing 3	Mus musculus	14-19
33272570-9	2021	Moreover, a challenge of rmIL-1beta reversed the improvement in Nlrp3-/- mice or the mice treated with baicalein.	rmil-1beta	25-35	NLR family, pyrin domain containing 3	Mus musculus	64-69
33260093-2	2021	Inflammasome is a newly-found and promising target for effective treatment of immunity-associated diseases including liver disease, and dopamine has recently been proved as an inhibitor for NLRP3 inflammasome.	Dopamine	136-144	NLR family, pyrin domain containing 3	Mus musculus	190-195
33232925-2	2021	This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome-mediated pyroptosis.	Uric Acid	28-37	NLR family, pyrin domain containing 3	Mus musculus	74-79
33232925-2	2021	This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome-mediated pyroptosis.	Uric Acid	39-41	NLR family, pyrin domain containing 3	Mus musculus	74-79
33232925-10	2021	CONCLUSION: UA aggravates MI/R-induced activation of the NLRP3 inflammatory cascade and pyroptosis by promoting ROS generation, while inflammasome inhibitors and ROS scavengers partly reverse the injury.	Uric Acid	12-14	NLR family, pyrin domain containing 3	Mus musculus	57-62
33260093-3	2021	This work demonstrates a diselenide-based nanodrug for ALF treatment through inhibiting NLRP3 inflammasome activation and enhancing liver regeneration.	diselenium	25-35	NLR family, pyrin domain containing 3	Mus musculus	88-93
33260093-5	2021	As a nanoscale prodrug, SW@DSeSeD protects its payloads from decomposition in bloodstream upon administration, accumulates in liver of ALF mice, then responds to the overexpressed ROS and thereby releases SW033291 as well as a stable dopamine precursor that can transform into dopamine in hepatic cells, thus achieving significant therapeutic efficacy against ALF through inhibiting NLRP3 inflammasome activation and enhancing hepatic regeneration.	ros	180-183	NLR family, pyrin domain containing 3	Mus musculus	383-388
33232925-10	2021	CONCLUSION: UA aggravates MI/R-induced activation of the NLRP3 inflammatory cascade and pyroptosis by promoting ROS generation, while inflammasome inhibitors and ROS scavengers partly reverse the injury.	Arginine	29-30	NLR family, pyrin domain containing 3	Mus musculus	57-62
33260093-5	2021	As a nanoscale prodrug, SW@DSeSeD protects its payloads from decomposition in bloodstream upon administration, accumulates in liver of ALF mice, then responds to the overexpressed ROS and thereby releases SW033291 as well as a stable dopamine precursor that can transform into dopamine in hepatic cells, thus achieving significant therapeutic efficacy against ALF through inhibiting NLRP3 inflammasome activation and enhancing hepatic regeneration.	Dopamine	234-242	NLR family, pyrin domain containing 3	Mus musculus	383-388
33260093-5	2021	As a nanoscale prodrug, SW@DSeSeD protects its payloads from decomposition in bloodstream upon administration, accumulates in liver of ALF mice, then responds to the overexpressed ROS and thereby releases SW033291 as well as a stable dopamine precursor that can transform into dopamine in hepatic cells, thus achieving significant therapeutic efficacy against ALF through inhibiting NLRP3 inflammasome activation and enhancing hepatic regeneration.	Dopamine	277-285	NLR family, pyrin domain containing 3	Mus musculus	383-388
33232925-10	2021	CONCLUSION: UA aggravates MI/R-induced activation of the NLRP3 inflammatory cascade and pyroptosis by promoting ROS generation, while inflammasome inhibitors and ROS scavengers partly reverse the injury.	Reactive Oxygen Species	112-115	NLR family, pyrin domain containing 3	Mus musculus	57-62
33039664-10	2021	These findings demonstrate that impairing microglial autophagy aggravates pro-inflammatory responses to LPS and exacerbates MPTP-induced neurodegeneration by modulating NLRP3 inflammasome responses.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	124-128	NLR family, pyrin domain containing 3	Mus musculus	169-174
32971182-0	2021	Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of Parkin-mediated Mitophagy in in-vitro and in-vivo models of Parkinson disease.	andrographolide	0-15	NLR family, pyrin domain containing 3	Mus musculus	27-32
32971182-6	2021	The idea of using MPP+ after priming mouse microglia with LPS was to disrupt mitochondria and release reactive oxygen species, which act as Signal 2 in augmenting NLRP3 assembly, thereby releasing potent inflammatory mediators such as active interleukin-1 beta (IL-1beta) and IL-18.	Oxygen	111-117	NLR family, pyrin domain containing 3	Mus musculus	163-168
31846964-3	2021	The objective of this study was to determine the role of the NLRP3 inflammasome in 5-FU-induced small intestinal mucositis.	Fluorouracil	83-87	NLR family, pyrin domain containing 3	Mus musculus	61-66
32971182-8	2021	Treatment with Andrographolide promoted the parkin-dependent autophagic flux formation in microglia; resulting in the removal of defective mitochondria which in turn inhibit NLRP3 inflammasome activation.	andrographolide	15-30	NLR family, pyrin domain containing 3	Mus musculus	174-179
32971182-9	2021	Additionally, the neuroprotective role of Andrographolide in inhibiting NLRP3 activation together with salvage ATP level via promoting parkin-dependent mitophagy was seen in the substantial nigra par compacta (SNpc) region of mice brain.	andrographolide	42-57	NLR family, pyrin domain containing 3	Mus musculus	72-77
32971182-12	2021	In addition, andrographolide was seen to abate NLRP3 inflammasome activation in microglia and rescue dopaminergic neuron loss.	andrographolide	13-28	NLR family, pyrin domain containing 3	Mus musculus	47-52
33459112-0	2021	LncRNA MIAT downregulates IL-1beta, TNF-alpha to suppress macrophage inflammation but is suppressed by ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	103-106	NLR family, pyrin domain containing 3	Mus musculus	115-120
33459112-7	2021	LncRNA MIAT seemed to inhibit the expression of IL-1beta, TNF-alpha and be suppressed by ATP-induced NLRP3 inflammasome activation pathway.	Adenosine Triphosphate	89-92	NLR family, pyrin domain containing 3	Mus musculus	101-106
31846964-4	2021	METHODS: Small intestinal mucositis was induced in wild-type, NLRP3-/-, and caspase-1-/- mice by intraperitoneal injection of 5-FU.	Fluorouracil	126-130	NLR family, pyrin domain containing 3	Mus musculus	62-67
31846964-9	2021	NLRP3-/- mice exhibited less severe 5-FU-induced mucositis, and this phenotype was mimicked by genetic depletion or pharmacological inhibition of caspase-1.	Fluorouracil	36-40	NLR family, pyrin domain containing 3	Mus musculus	0-5
31846964-13	2021	CONCLUSIONS: NLRP3 inflammasome activation may exacerbate 5-FU-induced small intestinal mucositis via IL-1beta maturation.	Fluorouracil	58-62	NLR family, pyrin domain containing 3	Mus musculus	13-18
33217525-5	2021	In mouse livers, PAT induced pyroptosis, and increased inflammation through the activation of NLRP3 inflammasome.	Patulin	17-20	NLR family, pyrin domain containing 3	Mus musculus	94-99
32949934-6	2021	NLRP3 inflammasome-mediated pyroptosis axis (NLRP3, ASC, GSDMD, caspase-1, IL-1beta, and IL-18) were activated in the PM2.5-treated HCECs, accompanied by increased ROS formation.	Reactive Oxygen Species	164-167	NLR family, pyrin domain containing 3	Mus musculus	0-5
33217525-7	2021	In addition, PAT-induced pyroptosis was dependent upon the activation of NLRP3 inflammasome and the release of cathepsin B.	Patulin	13-16	NLR family, pyrin domain containing 3	Mus musculus	73-78
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	30-45	NLR family, pyrin domain containing 3	Mus musculus	169-174
33217525-10	2021	Moreover, autophagy inhibitor 3-methyladenine (3MA) attenuated PAT-induced increase in cytoplasmic cathepsin B expression, and subsequent LDH release, the activation of NLRP3 inflamosomes, pyroptotic cell death, and inflammation.	3-methyladenine	47-50	NLR family, pyrin domain containing 3	Mus musculus	169-174
33168408-0	2021	The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice.	oridonin	42-50	NLR family, pyrin domain containing 3	Mus musculus	13-18
33212186-8	2021	Interestingly, inhibition of NADPH oxidase by apocynin or specific siRNAs significantly mitigated HD-induced NLRP3 inflammasome activation.	acetovanillone	46-54	NLR family, pyrin domain containing 3	Mus musculus	109-114
33074353-0	2021	Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation.	Uric Acid	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
33074353-14	2021	In vitro, we showed that soluble uric acid alone increased the expression of TSPO, depolarized mitochondrial membrane potential, increased ROS release and activated NLRP3 inflammasome, which further reduced the expression of occludin and claudin-1.	Uric Acid	33-42	NLR family, pyrin domain containing 3	Mus musculus	165-170
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	44-49
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	128-133
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	175-178	NLR family, pyrin domain containing 3	Mus musculus	44-49
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	175-178	NLR family, pyrin domain containing 3	Mus musculus	128-133
33074353-17	2021	CONCLUSIONS: In conclusion, uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome.	Uric Acid	28-37	NLR family, pyrin domain containing 3	Mus musculus	98-103
32582954-6	2021	METHODS: NLRP3 inflammasome in macrophages from IL-37d transgenic (IL-37dtg) and control wild type (WT) mice were activated by lipopolysaccharide and adenosine 5"-triphosphate.	Adenosine	150-159	NLR family, pyrin domain containing 3	Mus musculus	9-14
32582954-9	2021	RESULTS: Our results showed that the activation of NLRP3 inflammasome in macrophage and alum-induced peritonitis was inhibited by IL-37d.	aluminum sulfate	88-92	NLR family, pyrin domain containing 3	Mus musculus	51-56
33168408-3	2021	Oridonin is a newly reported NLRP3 inhibitor with strong anti-inflammatory activity.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	29-34
33168408-4	2021	We hypothesized that the covalent NLRP3 inhibitor Oridonin could reduce IL-1beta and IL-18 expression and ameliorate myocardial fibrosis after myocardial infarction in mice, improve poor heart remodeling, and preserve heart function.	oridonin	50-58	NLR family, pyrin domain containing 3	Mus musculus	34-39
33168408-11	2021	The expression levels of NLRP3, IL-1beta and IL-18 were decreased in the Oridonin treatment group compared to non-treated group.	oridonin	73-81	NLR family, pyrin domain containing 3	Mus musculus	25-30
33290962-0	2021	Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome.	NAD	0-33	NLR family, pyrin domain containing 3	Mus musculus	156-161
33290962-9	2021	Treatment with NAD + also inhibited the expressions of NLRP3 and modulated the differentiation of Th1 and Th17 cells, reduced the expressions of the pro-inflammatory factors IL-1beta, IL-2, IL-18, IFN-gamma and IL-17, and increased the expression of anti-inflammatory IL-10.	NAD	15-20	NLR family, pyrin domain containing 3	Mus musculus	55-60
33290962-12	2021	Our results indicate that NAD + suppresses the NLRP3 inflammasome at least in part through the activation of autophagy to relieve the symptoms of EAE.	NAD	26-31	NLR family, pyrin domain containing 3	Mus musculus	47-52
33168408-13	2021	CONCLUSIONS: The covalent NLRP3-inflammasome inhibitor Oridonin reduces myocardial fibrosis and preserves cardiac function in a mouse MI model, which indicates potential therapeutic effect of Oridonin on acute MI patients.	oridonin	55-63	NLR family, pyrin domain containing 3	Mus musculus	26-31
33168408-13	2021	CONCLUSIONS: The covalent NLRP3-inflammasome inhibitor Oridonin reduces myocardial fibrosis and preserves cardiac function in a mouse MI model, which indicates potential therapeutic effect of Oridonin on acute MI patients.	oridonin	192-200	NLR family, pyrin domain containing 3	Mus musculus	26-31
32761488-0	2021	Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway activation: an in vivo and in vitro study.	dioscin	21-28	NLR family, pyrin domain containing 3	Mus musculus	111-116
33290968-0	2021	Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-kappaB-NLRP3 inflammasome signaling pathway.	pinocembrin	0-11	NLR family, pyrin domain containing 3	Mus musculus	110-115
33290968-0	2021	Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-kappaB-NLRP3 inflammasome signaling pathway.	Bleomycin	44-53	NLR family, pyrin domain containing 3	Mus musculus	110-115
33217488-0	2021	Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis.	Ellagic Acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	122-127
33217488-9	2021	Besides, ellagic acid lowered tissue levels of NLRP3 and caspase 1 in addition to its mitigation of neuroinflammation, demyelination and axonal damage in spinal cord specimens of EAE group.	Ellagic Acid	9-21	NLR family, pyrin domain containing 3	Mus musculus	47-52
33217488-11	2021	Taken together, ellagic acid can decrease severity of EAE via amelioration of astrogliosis, astrocyte activation, demyelination, neuroinflammation and axonal damage that is partly related to its effects on NLRP3 inflammasome and pyroptotic pathway.	Ellagic Acid	16-28	NLR family, pyrin domain containing 3	Mus musculus	206-211
33307514-6	2021	Concomitant with enlarged colonic patches, the cultured colon of infected mice treated with berberine secreted significantly higher levels of interleukin-1beta (IL-1beta), IL-6, TNF-alpha, and CCL-2, while NLRP3 inhibitor MMC950 or knockout of NLRP3 gene abrogated berberine-induced hypertrophy of colonic patches, suggesting the involvement of the NLRP3 signaling pathway in this process.	Berberine	92-101	NLR family, pyrin domain containing 3	Mus musculus	206-211
33307514-6	2021	Concomitant with enlarged colonic patches, the cultured colon of infected mice treated with berberine secreted significantly higher levels of interleukin-1beta (IL-1beta), IL-6, TNF-alpha, and CCL-2, while NLRP3 inhibitor MMC950 or knockout of NLRP3 gene abrogated berberine-induced hypertrophy of colonic patches, suggesting the involvement of the NLRP3 signaling pathway in this process.	Berberine	92-101	NLR family, pyrin domain containing 3	Mus musculus	244-249
33307514-6	2021	Concomitant with enlarged colonic patches, the cultured colon of infected mice treated with berberine secreted significantly higher levels of interleukin-1beta (IL-1beta), IL-6, TNF-alpha, and CCL-2, while NLRP3 inhibitor MMC950 or knockout of NLRP3 gene abrogated berberine-induced hypertrophy of colonic patches, suggesting the involvement of the NLRP3 signaling pathway in this process.	Berberine	92-101	NLR family, pyrin domain containing 3	Mus musculus	244-249
32761488-7	2021	Western blotting results suggested that dioscin inhibited the activation of NLRP3 through down-regulating the protein expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved-caspase-1, as well as IL-1beta.	dioscin	40-47	NLR family, pyrin domain containing 3	Mus musculus	76-81
32761488-7	2021	Western blotting results suggested that dioscin inhibited the activation of NLRP3 through down-regulating the protein expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved-caspase-1, as well as IL-1beta.	dioscin	40-47	NLR family, pyrin domain containing 3	Mus musculus	133-138
32761488-10	2021	Taken together, dioscin had a protective effect against MSU-initiated inflammatory response via repressing the production of inflammatory cytokines and the activation of inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway.	dioscin	16-23	NLR family, pyrin domain containing 3	Mus musculus	183-188
32761488-10	2021	Taken together, dioscin had a protective effect against MSU-initiated inflammatory response via repressing the production of inflammatory cytokines and the activation of inflammasome NLRP3 and TLR4/NF-kappaB signaling pathway.	Uric Acid	56-59	NLR family, pyrin domain containing 3	Mus musculus	183-188
32902019-0	2021	Nodakenin alleviates renal ischemia-reperfusion injury via inhibiting ROS induced NLRP3 inflammasome activation.	ros	70-73	NLR family, pyrin domain containing 3	Mus musculus	82-87
33347772-6	2021	Results: GLY protected against loss of cell viability induced by HG and significantly reduced HMGB1, IL-1beta, TLR2, TLR4, NLRP3, COX2, SOD2, HO-1, GPX2, and GR1.	Glycyrrhizic Acid	9-12	NLR family, pyrin domain containing 3	Mus musculus	123-128
33523018-10	2021	Gly(2)-GLP-2 furthermore reduced the inflammation response as seen in lower microglia activation, and decreased NLRP3 and interleukin-1beta pro-inflammatory cytokine expression levels.	Glycine	0-3	NLR family, pyrin domain containing 3	Mus musculus	112-117
33523018-13	2021	CONCLUSION: The present results demonstrate that Gly(2)-GLP-2 can attenuate NLRP3 inflammasome-mediated inflammation and mitochondrial damage in the substantia nigra induced by MPTP, and Gly(2)-GLP-2 shows neuroprotective effects in this PD animal model.	Glycylglycine	49-55	NLR family, pyrin domain containing 3	Mus musculus	76-81
33523018-13	2021	CONCLUSION: The present results demonstrate that Gly(2)-GLP-2 can attenuate NLRP3 inflammasome-mediated inflammation and mitochondrial damage in the substantia nigra induced by MPTP, and Gly(2)-GLP-2 shows neuroprotective effects in this PD animal model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	177-181	NLR family, pyrin domain containing 3	Mus musculus	76-81
33274576-6	2021	A maternal LC diet significantly increased Tlr4 transcription, causing premature neuronal differentiation and enhanced ethanol-induced NLRP3 inflammasome activation.	Ethanol	119-126	NLR family, pyrin domain containing 3	Mus musculus	135-140
33157234-9	2021	In conclusion, our findings indicate that alcohol increases the methylation of PPAR-alpha m6A by FTO-mediated YTHDF2 epigenetic modification, which ultimately leads to the activation of NLRP3 inflammasomes and NF-kappaB-driven renal inflammation in the kidney.	Alcohols	42-49	NLR family, pyrin domain containing 3	Mus musculus	186-191
32776627-5	2021	Further studies found that celastrol decreased the infiltration of macrophage as well as its inflammatory products (IL-1beta, IL-18, MCP-1alpha, and TNF-alpha) in liver and adipose tissues, which also displayed an obvious inhibition of TLR3/NLRP3 inflammasome molecules.	celastrol	27-36	NLR family, pyrin domain containing 3	Mus musculus	241-246
33157234-4	2021	In this study, we found that the administration of alcohol was associated with the activation of NLRP3 inflammasomes and NF-kappaB signaling, and the production of pro-inflammatory cytokines.	Alcohols	51-58	NLR family, pyrin domain containing 3	Mus musculus	97-102
33290778-5	2021	Arsenic exposure induced hepatic injury and resulted in the activations of p-AKT2, NF-kappaB p65, and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, downregulation of Sema 3A, and upregulation of Sema 4A or NRP-1.	Arsenic	0-7	NLR family, pyrin domain containing 3	Mus musculus	102-152
33130474-4	2021	METHODS: The influence of celastrol on NLRP3 inflammasome activation was firstly studied in lipopolysaccharide (LPS)-primed mouse bone marrow-derived macrophages (BMDMs) and phorbol 12-myristate 13-acetate (PMA)-primed THP-1 cells treated with nigericin.	celastrol	26-35	NLR family, pyrin domain containing 3	Mus musculus	39-44
33242555-3	2021	Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome.	Uric Acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	67-72
33242555-3	2021	Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome.	Uric Acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	74-110
33242555-3	2021	Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome.	Uric Acid	18-21	NLR family, pyrin domain containing 3	Mus musculus	67-72
33242555-3	2021	Monosodium urate (MSU) is known to be one of the activators of the NLRP3 (NLR family pyrin domain containing 3) inflammasome.	Uric Acid	18-21	NLR family, pyrin domain containing 3	Mus musculus	74-110
33242555-11	2021	In addition, AND decreased MSU-mediated ASC binding to NLRP3.	Uric Acid	27-30	NLR family, pyrin domain containing 3	Mus musculus	55-60
33242555-13	2021	These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release.	Uric Acid	78-81	NLR family, pyrin domain containing 3	Mus musculus	169-174
33290778-5	2021	Arsenic exposure induced hepatic injury and resulted in the activations of p-AKT2, NF-kappaB p65, and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, downregulation of Sema 3A, and upregulation of Sema 4A or NRP-1.	Arsenic	0-7	NLR family, pyrin domain containing 3	Mus musculus	154-159
33242555-13	2021	These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release.	ros	156-159	NLR family, pyrin domain containing 3	Mus musculus	169-174
33290778-7	2021	And, the inflammatory signaling p-AKT2 or NF-kappaB p65, and NLRP3 inflammasome showed a downregulation compared with arsenic treatment group.	Arsenic	118-125	NLR family, pyrin domain containing 3	Mus musculus	61-66
33158955-3	2020	Proteomic profiling of alveolar macrophages of Mincle transgenic (tg) mice stimulated with the Mincle-specific pneumococcal ligand glucosyl-diacylglycerol (Glc-DAG) revealed increased Nlrp3 inflammasome activation and downstream IL-1beta cytokine release that was not observed in Glc-DAG-stimulated Mincle knockout or Nlrp3 knockout macrophages.	glucosyl diacylglycerol	131-154	NLR family, pyrin domain containing 3	Mus musculus	184-189
33488936-5	2020	Moreover, dioscin also can reduce the production of proinflammatory factors such as interleukin-1 beta (IL-1beta) and inhibit the activation of NLRP3 inflammasome in LPS-induced mice mastitis.	dioscin	10-17	NLR family, pyrin domain containing 3	Mus musculus	144-149
33488936-6	2020	In vitro experiments, the results showed that dioscin inhibited the inflammatory response and the activation of NLRP3 inflammasome, but the survival rate of mouse mammary epithelial cells (mMECs) induced by LPS+ATP is increased.	dioscin	46-53	NLR family, pyrin domain containing 3	Mus musculus	112-117
33488936-8	2020	Further mechanistic studies demonstrate that dioscin can activate AMPK/Nrf2 to inhibit NLRP3/GSDMD-induced mMEC pyroptosis.	dioscin	45-52	NLR family, pyrin domain containing 3	Mus musculus	87-92
33351536-0	2020	Vinpocetine attenuates ischemic stroke through inhibiting NLRP3 inflammasome expression in mice.	vinpocetine	0-11	NLR family, pyrin domain containing 3	Mus musculus	58-63
33351536-3	2020	Here, we examined vinpocetine (Vinp), a synthetic drug, playing a neuroprotective role against ischemic stroke in mice through regulating NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation.	vinpocetine	18-29	NLR family, pyrin domain containing 3	Mus musculus	138-188
33351536-3	2020	Here, we examined vinpocetine (Vinp), a synthetic drug, playing a neuroprotective role against ischemic stroke in mice through regulating NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation.	vinpocetine	18-29	NLR family, pyrin domain containing 3	Mus musculus	190-195
33351536-3	2020	Here, we examined vinpocetine (Vinp), a synthetic drug, playing a neuroprotective role against ischemic stroke in mice through regulating NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation.	vinpocetine	31-35	NLR family, pyrin domain containing 3	Mus musculus	138-188
33351536-3	2020	Here, we examined vinpocetine (Vinp), a synthetic drug, playing a neuroprotective role against ischemic stroke in mice through regulating NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation.	vinpocetine	31-35	NLR family, pyrin domain containing 3	Mus musculus	190-195
33351536-8	2020	The experimental results indicated that post-treatment with Vinp decreased cerebral infarct size, improved behavior recover, reduced NLRP3 inflammasome expression, suppress the transfer of NF-kappaB to nucleus and pro-inflammatory cytokines release in MCAO/R mice.	vinpocetine	60-64	NLR family, pyrin domain containing 3	Mus musculus	133-138
33353046-0	2020	Melatonin Reduces NLRP3 Inflammasome Activation by Increasing alpha7 nAChR-Mediated Autophagic Flux.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	18-23
33353046-3	2020	In this work, we have focused on studying the effect of melatonin on the regulation of the NLRP3 inflammasome through alpha7 nicotinic receptor (nAChR) and its relationship with autophagy.	Melatonin	56-65	NLR family, pyrin domain containing 3	Mus musculus	91-96
33353046-10	2020	In vivo, melatonin reverted LPS-induced cognitive decline, reduced NLRP3 levels and promoted autophagic flux in the hippocampi of WT mice, whereas in alpha7 nAChR KO mice melatonin effect was not observed.	Melatonin	9-18	NLR family, pyrin domain containing 3	Mus musculus	67-72
33391509-0	2021	Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.	pubescenoside A	54-69	NLR family, pyrin domain containing 3	Mus musculus	106-111
33391509-9	2021	PBA suppressed NLRP3 inflammation activation and induced the Nrf2 signaling pathway.	pubescenoside A	0-3	NLR family, pyrin domain containing 3	Mus musculus	15-20
33377532-0	2021	Oridonin alleviates d-GalN/LPS-induced acute liver injury by inhibiting NLRP3 inflammasome.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	72-77
33377532-3	2021	Oridonin is a natural substance with an anti-inflammatory effect and has been reported to be an inhibitor of NLRP3.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	109-114
33377532-10	2021	More importantly, oridonin markedly reduced the expression of NLRP3, caspase-1, IL-18, and IL-1beta.	oridonin	18-26	NLR family, pyrin domain containing 3	Mus musculus	62-67
33377532-11	2021	This study showed that oridonin has a protective effect on d-GalN/LPS-induced ALI, and the underlying mechanisms may be associated with the inhibition of the NLRP3 inflammatory pathways.	oridonin	23-31	NLR family, pyrin domain containing 3	Mus musculus	158-163
33490912-5	2021	Here, we investigated whether LRV interferes with the inflammasome via caspase-11, which induces non-canonical NLRP3 activation and was reported to be activated by Leishmania.	(8alpha,9beta,10alpha,13alpha)-13-{[alpha-L-allopyranosyl-(1->2)-[beta-D-mannopyranosyl-(1->3)]-beta-D-allopyranosyl]oxy}kauran-18-oic acid	30-33	NLR family, pyrin domain containing 3	Mus musculus	111-116
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	Oxysterols	88-97	NLR family, pyrin domain containing 3	Mus musculus	132-137
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	98-115	NLR family, pyrin domain containing 3	Mus musculus	132-137
33409276-4	2020	In the present study, we found that in cultured carotid ECs, atherogenic stimulation by oxysterol 7-ketocholesterol (7-Ket) induced NLRP3 inflammasome formation and activation, reduced lysosome-multivesicular bodies (MVBs) fusion, and increased secretion of EVs that contain inflammasome product IL-1beta.	7-ketocholesterol	117-122	NLR family, pyrin domain containing 3	Mus musculus	132-137
33158955-3	2020	Proteomic profiling of alveolar macrophages of Mincle transgenic (tg) mice stimulated with the Mincle-specific pneumococcal ligand glucosyl-diacylglycerol (Glc-DAG) revealed increased Nlrp3 inflammasome activation and downstream IL-1beta cytokine release that was not observed in Glc-DAG-stimulated Mincle knockout or Nlrp3 knockout macrophages.	glucosyl diacylglycerol	131-154	NLR family, pyrin domain containing 3	Mus musculus	318-323
33158955-6	2020	Together, we show that overexpression of the pattern recognition receptor Mincle triggers increased Glc-DAG-dependent Nlrp3 inflammasome activation in professional phagocytes leading to fatal pneumococcal pneumonia in mice that is amenable to Nlrp3 inhibitor treatment.	glucosyl diacylglycerol	100-107	NLR family, pyrin domain containing 3	Mus musculus	118-123
33158955-6	2020	Together, we show that overexpression of the pattern recognition receptor Mincle triggers increased Glc-DAG-dependent Nlrp3 inflammasome activation in professional phagocytes leading to fatal pneumococcal pneumonia in mice that is amenable to Nlrp3 inhibitor treatment.	glucosyl diacylglycerol	100-107	NLR family, pyrin domain containing 3	Mus musculus	243-248
33362467-0	2020	TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells.	Midazolam	25-34	NLR family, pyrin domain containing 3	Mus musculus	42-47
33362467-7	2020	Furthermore, a combination of LPS and ATP was used to activate the NLRP3 inflammasome.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	67-72
33362775-0	2020	Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.	bixin	0-5	NLR family, pyrin domain containing 3	Mus musculus	80-85
33362775-7	2020	And bixin reduced the proportion of Th1 and Th17 cells in the spleen and CNS, and suppressed microglia aggregation, and TXNIP/NLRP3 inflammasome activity by scavenging excessive reactive oxygen species (ROS) in EAE mice.	bixin	4-9	NLR family, pyrin domain containing 3	Mus musculus	126-131
33316945-5	2020	Our results demonstrated that Dox significantly reduced muscle function in mice, which was associated with a significant increase in NLRP3 inflammasome and initiation marker TLR4 as compared with controls.	Doxorubicin	30-33	NLR family, pyrin domain containing 3	Mus musculus	133-138
33214151-3	2020	We now show that RBP4 primes the NLRP3 inflammasome for interleukin-1beta (IL1beta) release, in a glucose-dependent manner, through the TLR4/MD2 receptor complex and TLR2.	Glucose	98-105	NLR family, pyrin domain containing 3	Mus musculus	33-38
33365024-0	2020	Gallic Acid Alleviates Gouty Arthritis by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis Through Enhancing Nrf2 Signaling.	Gallic Acid	0-11	NLR family, pyrin domain containing 3	Mus musculus	53-58
33365024-3	2020	However, how gallic acid affects the NLRP3 inflammasome remains unclear.	Gallic Acid	13-24	NLR family, pyrin domain containing 3	Mus musculus	37-42
33365024-4	2020	Therefore, in the present study, we investigated the mechanisms underlying the effects of gallic acid on the NLRP3 inflammasome and pyroptosis, as well as its effect on gouty arthritis in mice.	Gallic Acid	90-101	NLR family, pyrin domain containing 3	Mus musculus	109-114
33365024-6	2020	Additionally, gallic acid blocked NLRP3 inflammasome activation and inhibited the subsequent activation of caspase-1 and secretion of IL-1beta.	Gallic Acid	14-25	NLR family, pyrin domain containing 3	Mus musculus	34-39
33365024-7	2020	Gallic acid exerted its inhibitory effect by blocking NLRP3-NEK7 interaction and ASC oligomerization, thereby limiting inflammasome assembly.	Gallic Acid	0-11	NLR family, pyrin domain containing 3	Mus musculus	54-59
33365024-13	2020	In summary, we found that gallic acid suppresses ROS generation, thereby limiting NLRP3 inflammasome activation and pyroptosis dependent on Nrf2 signaling, suggesting that gallic acid possesses therapeutic potential for the treatment of gouty arthritis.	Gallic Acid	26-37	NLR family, pyrin domain containing 3	Mus musculus	82-87
33365024-13	2020	In summary, we found that gallic acid suppresses ROS generation, thereby limiting NLRP3 inflammasome activation and pyroptosis dependent on Nrf2 signaling, suggesting that gallic acid possesses therapeutic potential for the treatment of gouty arthritis.	Gallic Acid	172-183	NLR family, pyrin domain containing 3	Mus musculus	82-87
33344657-0	2020	Anemoside B4 Protects against Acute Lung Injury by Attenuating Inflammation through Blocking NLRP3 Inflammasome Activation and TLR4 Dimerization.	anemoside B4	0-12	NLR family, pyrin domain containing 3	Mus musculus	93-98
33041005-3	2020	We found that Nlrp3-/- and WT mice showed similar mortality against a lethal dose of D-GalN/LPS treatment.	Galactosamine	85-91	NLR family, pyrin domain containing 3	Mus musculus	14-19
33041005-6	2020	Besides, Nlrp3-/- mice had reduced IL-1beta levels but similar TNF-alpha, IL-6, and MCP-1 levels compared with WT mice upon D-GalN/LPS administration.	Galactosamine	124-130	NLR family, pyrin domain containing 3	Mus musculus	9-14
33041005-1	2020	The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF).	Leucine	34-41	NLR family, pyrin domain containing 3	Mus musculus	99-104
33041005-1	2020	The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF).	Galactosamine	230-245	NLR family, pyrin domain containing 3	Mus musculus	99-104
33041005-1	2020	The nucleotide-binding domain and leucine-rich repeat-containing family pyrin domain containing 3 (NLRP3) inflammasome is involved in various acute and chronic liver diseases, however, it is not clear whether NLRP3 contributes to d-Galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced acute liver failure (ALF).	Galactosamine	247-253	NLR family, pyrin domain containing 3	Mus musculus	99-104
33041005-2	2020	This study aims to investigate the role of NLRP3 inflammasome in D-GalN/LPS-induced fatal hepatitis.	Galactosamine	65-71	NLR family, pyrin domain containing 3	Mus musculus	43-48
32003282-4	2020	Mechanistically, we found that inhibition of autophagy led to NLRP3 (NLR family pyrin domain containing 3) inflammasome activation via PDE10A (phosphodiesterase 10A)-cyclic adenosine monophosphate (cAMP) signaling in microglia, and the sequential upregulation of downstream IL1B/IL-1beta in turn increased the expression of MIF (macrophage migration inhibitory factor [glycosylation-inhibiting factor]), a pro-inflammatory cytokine.	Cyclic AMP	166-196	NLR family, pyrin domain containing 3	Mus musculus	62-67
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	Ceramides	46-54	NLR family, pyrin domain containing 3	Mus musculus	6-11
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	Fatty Acids	141-152	NLR family, pyrin domain containing 3	Mus musculus	6-11
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	mono-saturated fa	169-186	NLR family, pyrin domain containing 3	Mus musculus	6-11
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	Fatty Acids, Unsaturated	198-216	NLR family, pyrin domain containing 3	Mus musculus	6-11
33273482-4	2020	Obese NLRP3 deficient mice had lower systemic ceramide levels, potentially resulting attenuating inflammation, altered hepatic expression of fatty acids (FA) with lower mono-saturated FA and higher polyunsaturated FA levels, potentially counteracting development of liver steatosis, downregulated myocardial energy metabolism as assessed by proteomic analyses of LV heart tissue, and different levels of bile acids as compared with WT mice.	Bile Acids and Salts	404-414	NLR family, pyrin domain containing 3	Mus musculus	6-11
32003282-4	2020	Mechanistically, we found that inhibition of autophagy led to NLRP3 (NLR family pyrin domain containing 3) inflammasome activation via PDE10A (phosphodiesterase 10A)-cyclic adenosine monophosphate (cAMP) signaling in microglia, and the sequential upregulation of downstream IL1B/IL-1beta in turn increased the expression of MIF (macrophage migration inhibitory factor [glycosylation-inhibiting factor]), a pro-inflammatory cytokine.	Cyclic AMP	166-196	NLR family, pyrin domain containing 3	Mus musculus	69-105
32700178-0	2020	Toll-Like Receptor 9 Is Involved in NLRP3 Inflammasome Activation and IL-1beta Production Through Monosodium Urate-Induced Mitochondrial DNA.	Uric Acid	98-114	NLR family, pyrin domain containing 3	Mus musculus	36-41
33178347-0	2020	Sophocarpine attenuates septic liver injury through suppression of the NLRP3 inflammasome via autophagy-mediated degradation.	sophocarpine	0-12	NLR family, pyrin domain containing 3	Mus musculus	71-76
33178347-2	2020	Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome activation has been suggested to be a major cause of hepatocyte cell death in liver diseases.	Leucine	43-50	NLR family, pyrin domain containing 3	Mus musculus	94-99
33178347-6	2020	Additionally, sophocarpine appeared to have suppressed the activation of the NLRP3 inflammasome, as indicated by observed reductions in liver IL-1beta, NLRP3, caspase 1-p20 and gasdermin D-p30 protein levels.	sophocarpine	14-26	NLR family, pyrin domain containing 3	Mus musculus	77-82
33178347-6	2020	Additionally, sophocarpine appeared to have suppressed the activation of the NLRP3 inflammasome, as indicated by observed reductions in liver IL-1beta, NLRP3, caspase 1-p20 and gasdermin D-p30 protein levels.	sophocarpine	14-26	NLR family, pyrin domain containing 3	Mus musculus	152-157
33178347-7	2020	Further investigation suggested that sophocarpine-induced autophagy was essential for this suppression of NLRP3 inflammasome activation, the inhibition of which reversed the protective effects of sophocarpine on CLP-induced liver injury.	sophocarpine	37-49	NLR family, pyrin domain containing 3	Mus musculus	106-111
33178347-8	2020	Collectively, results from the present study suggested a protective role for sophocarpine against septic liver injury, where sophocarpine may suppress NLRP3 inflammasome activation by autophagy-mediated degradation.	sophocarpine	125-137	NLR family, pyrin domain containing 3	Mus musculus	151-156
33017103-9	2020	Basic Protocol 4 describes how to induce NLRP3 inflammasome activation and peritonitis by priming mice with LPS and subsequently challenging them with monosodium urate (MSU).	Uric Acid	151-167	NLR family, pyrin domain containing 3	Mus musculus	41-46
33017103-9	2020	Basic Protocol 4 describes how to induce NLRP3 inflammasome activation and peritonitis by priming mice with LPS and subsequently challenging them with monosodium urate (MSU).	Uric Acid	169-172	NLR family, pyrin domain containing 3	Mus musculus	41-46
33098156-1	2020	In the brain, NLRP3 (Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3) inflammasome is mainly expressed in microglia located in the hippocampus and other mood-regulated regions, which are particularly susceptible to stress.	Leucine	64-71	NLR family, pyrin domain containing 3	Mus musculus	14-19
33098156-5	2020	Furthermore, we treated these mice with the antidepressant clomipramine (CLO) to observe its effect on depressive-like behaviors and the expression of the NLRP3 inflammasome and LPS-induced IDO.	Clomipramine	59-71	NLR family, pyrin domain containing 3	Mus musculus	155-160
33098156-5	2020	Furthermore, we treated these mice with the antidepressant clomipramine (CLO) to observe its effect on depressive-like behaviors and the expression of the NLRP3 inflammasome and LPS-induced IDO.	Clomipramine	73-76	NLR family, pyrin domain containing 3	Mus musculus	155-160
32941795-0	2020	Nano-engineered nerolidol loaded lipid carrier delivery system attenuates cyclophosphamide neurotoxicity - Probable role of NLRP3 inflammasome and caspase-1.	nerolidol	16-25	NLR family, pyrin domain containing 3	Mus musculus	124-129
32479684-7	2020	Pretreatment with omentin-1 inhibited lipopolysaccharide-induced inflammation via TXNIP/NLRP3 signaling in RAW 264.7 macrophages.	omentin-1	18-27	NLR family, pyrin domain containing 3	Mus musculus	88-93
33006110-0	2020	Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1beta and Cathepsin B in macrophages.	procyanidin B2	84-98	NLR family, pyrin domain containing 3	Mus musculus	51-56
33006110-4	2020	In two mouse models of gout, oral administration of PCB2 suppressed MSU crystals-induced increasing expression of IL-1beta, Cathepsin B and NLRP3 in the air pouch skin and paws, accompanied with the downregulation prostaglandin E2 (PGE2) in pouch exudates.	procyanidin B2	52-56	NLR family, pyrin domain containing 3	Mus musculus	140-145
32700178-1	2020	The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1beta and is considered a main pathogenic mechanism for uric acid-induced inflammation.	Uric Acid	190-199	NLR family, pyrin domain containing 3	Mus musculus	4-40
32700178-1	2020	The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is a cytoplasmic multimolecular complex that generates interleukin (IL)-1beta and is considered a main pathogenic mechanism for uric acid-induced inflammation.	Uric Acid	190-199	NLR family, pyrin domain containing 3	Mus musculus	42-47
32700178-2	2020	Whether toll-like receptor 9 (TLR9) is responsible for uric acid-induced NLRP3 inflammasome activation remains unclear.	Uric Acid	55-64	NLR family, pyrin domain containing 3	Mus musculus	73-78
32700178-3	2020	Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA.	Uric Acid	102-118	NLR family, pyrin domain containing 3	Mus musculus	64-69
32700178-3	2020	Thus, the aim of this study was to identify the role of TLR9 in NLRP3 inflammasome activation through monosodium urate (MSU) crystal-induced mitochondrial DNA.	Uric Acid	120-123	NLR family, pyrin domain containing 3	Mus musculus	64-69
32700178-6	2020	RAW 264.7 cells treated with CpG-ODN stimulated the activation of NF-kappaB signaling, the NLRP3 inflammasome components NLRP3, ASC, and caspase-1, and IL-1beta gene and protein expression.	CPG-oligonucleotide	29-36	NLR family, pyrin domain containing 3	Mus musculus	91-96
32700178-6	2020	RAW 264.7 cells treated with CpG-ODN stimulated the activation of NF-kappaB signaling, the NLRP3 inflammasome components NLRP3, ASC, and caspase-1, and IL-1beta gene and protein expression.	CPG-oligonucleotide	29-36	NLR family, pyrin domain containing 3	Mus musculus	121-126
32700178-10	2020	CpG-ODN and MSU crystals augmented the activation of NLRP3 inflammasome components and IL-1beta expression, which was significantly suppressed in RAW 264.7 cells transfected with TLR9 siRNA.	Uric Acid	12-15	NLR family, pyrin domain containing 3	Mus musculus	53-58
32700178-11	2020	This study suggests that TLR9 activated by MSU crystal-mediated mitochondrial DNA contributes to the activation of NLRP3 inflammasomes and IL-1beta production.	Uric Acid	43-46	NLR family, pyrin domain containing 3	Mus musculus	115-120
33166810-0	2020	GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-kappaB signaling pathways.	gamma-Aminobutyric Acid	0-4	NLR family, pyrin domain containing 3	Mus musculus	122-127
33166810-6	2020	We demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of GABA-mediated activation of nod-like receptor protein 3 (NLRP3) inflammasome and the nuclear factor kappa B (NF-kappaB) signaling pathway.	gamma-Aminobutyric Acid	193-197	NLR family, pyrin domain containing 3	Mus musculus	221-248
33166810-6	2020	We demonstrated that chronic cold stress induced the activation of microglia, the emergence of neuroinflammation, and the impairment of neurons in the hippocampus, which might be the result of GABA-mediated activation of nod-like receptor protein 3 (NLRP3) inflammasome and the nuclear factor kappa B (NF-kappaB) signaling pathway.	gamma-Aminobutyric Acid	193-197	NLR family, pyrin domain containing 3	Mus musculus	250-255
33217691-12	2020	Salidroside proves to control hyperglycemia and hepatic inflammation via inhibiting HMGB1/RAGE/NF-kappaB and HMGB1/TLR4/NLRP3 signaling pathways.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	120-125
32711407-9	2020	Treatment with RA suppressed the ovarian expression of the NLRP3 inflammasome and regulated the ovarian expression of apoptosis-related proteins.	rosmarinic acid	15-17	NLR family, pyrin domain containing 3	Mus musculus	59-64
32711407-10	2020	The results suggested that RA exhibited a protective effect against CP-induced POF potentially by suppressing apoptosis and the NLRP3 inflammasome.	rosmarinic acid	27-29	NLR family, pyrin domain containing 3	Mus musculus	128-133
32452554-0	2020	Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages.	epoxyeicosatrienoic acids	0-25	NLR family, pyrin domain containing 3	Mus musculus	52-57
32452554-4	2020	In this study, we investigated the effects of EETs on the activation of nucleotide-binding domain leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3) inflammasome in murine macrophages.	Leucine	98-105	NLR family, pyrin domain containing 3	Mus musculus	166-171
32452554-7	2020	TPPU treatment remarkably reduced the expression of NLRP3 inflammasome-related molecules and blocked the activation of NLRP3 inflammasome.	TPPU	0-4	NLR family, pyrin domain containing 3	Mus musculus	52-57
33068868-0	2020	Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting inflammation and the NLRP3 inflammasome: The role of the SIRT1/NF-kappaB pathway.	puerarin	0-8	NLR family, pyrin domain containing 3	Mus musculus	100-105
33045564-8	2020	Mechanistically, we found that CM from NLRP3 inflammasome-activated-macrophages increased the level of inhibitor kappaB kinase protein phosphorylation (p-IkappaBalpha) and reactive oxygen species (ROS) content, and promoted IkappaBalpha protein degradation in macrophages.	Reactive Oxygen Species	172-195	NLR family, pyrin domain containing 3	Mus musculus	39-44
33045564-8	2020	Mechanistically, we found that CM from NLRP3 inflammasome-activated-macrophages increased the level of inhibitor kappaB kinase protein phosphorylation (p-IkappaBalpha) and reactive oxygen species (ROS) content, and promoted IkappaBalpha protein degradation in macrophages.	Reactive Oxygen Species	197-200	NLR family, pyrin domain containing 3	Mus musculus	39-44
32452554-7	2020	TPPU treatment remarkably reduced the expression of NLRP3 inflammasome-related molecules and blocked the activation of NLRP3 inflammasome.	TPPU	0-4	NLR family, pyrin domain containing 3	Mus musculus	119-124
33045564-9	2020	While the inhibition of nuclear factor kappa-B (NF-kappaB) and scavenging ROS eliminated the up-regulation of TREM-1 induced by the NLRP3 inflammasome activation in macrophages.	Reactive Oxygen Species	74-77	NLR family, pyrin domain containing 3	Mus musculus	132-137
33068868-8	2020	More importantly, the SIRT1 inhibitor nicotinamide prevented these puerarin-induced cardioprotective effects and regulation of the SIRT1/NF-kappaB pathway, as well as the NLRP3 inflammasome activation.	Niacinamide	38-50	NLR family, pyrin domain containing 3	Mus musculus	171-176
33068868-8	2020	More importantly, the SIRT1 inhibitor nicotinamide prevented these puerarin-induced cardioprotective effects and regulation of the SIRT1/NF-kappaB pathway, as well as the NLRP3 inflammasome activation.	puerarin	67-75	NLR family, pyrin domain containing 3	Mus musculus	171-176
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	eets	18-22	NLR family, pyrin domain containing 3	Mus musculus	96-101
33068868-9	2020	CONCLUSION: Puerarin protected against MI/R injury by inhibiting inflammatory responses probably via the SIRT1/NF-kappaB pathway, and inhibition of the NLRP3 inflammasome was also involved in puerarin-induced cardioprotective effects.	puerarin	192-200	NLR family, pyrin domain containing 3	Mus musculus	152-157
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	5,6-epoxy-8,11,14-eicosatrienoic acid	24-31	NLR family, pyrin domain containing 3	Mus musculus	96-101
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	8,9-epoxyeicosatrienoic acid	33-40	NLR family, pyrin domain containing 3	Mus musculus	96-101
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	11,12-epoxy-5,8,14-eicosatrienoic acid	42-51	NLR family, pyrin domain containing 3	Mus musculus	96-101
33135320-0	2020	Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction.	Tromethamine	0-4	NLR family, pyrin domain containing 3	Mus musculus	74-79
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	14,15-epoxy-5,8,11-eicosatrienoic acid	57-66	NLR family, pyrin domain containing 3	Mus musculus	96-101
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	Adenosine Triphosphate	132-135	NLR family, pyrin domain containing 3	Mus musculus	96-101
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	Nigericin	145-154	NLR family, pyrin domain containing 3	Mus musculus	96-101
32452554-11	2020	In conclusion, this study suggests that EETs inhibit the activation of the NLRP3 inflammasome by suppressing calcium overload and ROS production in macrophages, contributing to the therapeutic potency to ALI.	Calcium	109-116	NLR family, pyrin domain containing 3	Mus musculus	75-80
32452554-11	2020	In conclusion, this study suggests that EETs inhibit the activation of the NLRP3 inflammasome by suppressing calcium overload and ROS production in macrophages, contributing to the therapeutic potency to ALI.	Reactive Oxygen Species	130-133	NLR family, pyrin domain containing 3	Mus musculus	75-80
32980473-0	2020	Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-kappaB, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	0-10	NLR family, pyrin domain containing 3	Mus musculus	95-100
33104527-5	2020	Furthermore, the activation of NLRP3, NLRC4, and AIM2 inflammasomes in both mouse and human cells was remarkably reduced by treatment with the HUWE1 inhibitor BI8622.	BI8622	159-165	NLR family, pyrin domain containing 3	Mus musculus	31-36
32980473-9	2020	Moreover, the western blot results indicated that Cl-amidine decreased the phosphorylation of IkappaB, p65, p38, ERK and the expression of NLRP3 in LPS-induced mouse mastitis.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	50-60	NLR family, pyrin domain containing 3	Mus musculus	139-144
32980473-11	2020	This study demonstrated that Cl-amidine decreased the pathological injury in LPS-induced mouse mastitis by inhibiting NF-kappaB, MAPK, NLRP3 signaling pathway and NETs release, which provides a potential candidate for the treatment of mastitis.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	29-39	NLR family, pyrin domain containing 3	Mus musculus	135-140
32555019-12	2020	CONCLUSIONS: Our findings suggest that voluntary running ameriolates mechanisms associated with vascular dysfunction by suppressing NLRP3 inflammasome, improving NO production, and reducing oxidative stress.	ameriolates	57-68	NLR family, pyrin domain containing 3	Mus musculus	132-137
33269646-9	2020	Results: Results showed that LPS plus ATP activated NLRP3 inflammasome, which evidenced by the up-regulation of TNF-alpha, IL-1beta and IL-18.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	52-57
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	NLR family, pyrin domain containing 3	Mus musculus	59-64
32311777-11	2020	Moreover, TUDCA, a specific ERS inhibitor, also reduced the expression of NLRP3 components in the hippocampus under SE conditions.	ursodoxicoltaurine	10-15	NLR family, pyrin domain containing 3	Mus musculus	74-79
33265944-8	2020	The exacerbation by BPA of hepatic immune-metabolic dysfunction induced by HFD was shown by increased toll-like receptor-4 and its downstream pathways (i.e., NF-kB and NLRP3 inflammasome) amplifying inflammatory cytokine transcription and promoting fibrosis progression.	bisphenol A	20-23	NLR family, pyrin domain containing 3	Mus musculus	168-173
33312339-7	2020	We used qRT-PCR and Western blotting assays and demonstrated that SA reduced the activation of the NLRP3 inflammasome and attenuated intestinal permeability by enhancing the expression of ZO-1, occludin, and claudin-1 in colitis mice.	sinapinic acid	66-68	NLR family, pyrin domain containing 3	Mus musculus	99-104
32947010-1	2020	Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to hepatic ischemia/reperfusion (I/R) injury, while the mechanism of how NLRP3 inflammasome is regulated remains less well defined.	Leucine	40-47	NLR family, pyrin domain containing 3	Mus musculus	105-110
33243234-10	2020	Functionally, Paxillin is essential for ATP-induced NLRP3 inflammasome activation in mouse BMDMs and BMDCs as well as in human PBMCs and THP-1-differentiated macrophages.	Adenosine Triphosphate	40-43	NLR family, pyrin domain containing 3	Mus musculus	52-57
32758727-10	2020	Moreover, we overexpressed NLRP3 using nigericin or lentiviral particles in GCs.	Nigericin	39-48	NLR family, pyrin domain containing 3	Mus musculus	27-32
32758727-13	2020	After inhibiting NLRP3, dihydrotestosterone (DHT)-treated GCs demonstrated markedly decreased NLRP3, the inflammasome adapter protein ASC, C-terminal fragment of gasdermin D (GSDMD-C), AR and Cyp19alpha1 at the protein level.	Dihydrotestosterone	24-43	NLR family, pyrin domain containing 3	Mus musculus	17-22
32758727-13	2020	After inhibiting NLRP3, dihydrotestosterone (DHT)-treated GCs demonstrated markedly decreased NLRP3, the inflammasome adapter protein ASC, C-terminal fragment of gasdermin D (GSDMD-C), AR and Cyp19alpha1 at the protein level.	Dihydrotestosterone	24-43	NLR family, pyrin domain containing 3	Mus musculus	94-99
32758727-13	2020	After inhibiting NLRP3, dihydrotestosterone (DHT)-treated GCs demonstrated markedly decreased NLRP3, the inflammasome adapter protein ASC, C-terminal fragment of gasdermin D (GSDMD-C), AR and Cyp19alpha1 at the protein level.	Dihydrotestosterone	45-48	NLR family, pyrin domain containing 3	Mus musculus	17-22
32758727-13	2020	After inhibiting NLRP3, dihydrotestosterone (DHT)-treated GCs demonstrated markedly decreased NLRP3, the inflammasome adapter protein ASC, C-terminal fragment of gasdermin D (GSDMD-C), AR and Cyp19alpha1 at the protein level.	Dihydrotestosterone	45-48	NLR family, pyrin domain containing 3	Mus musculus	94-99
32758727-15	2020	These findings suggest that hyperandrogen stimulates chronic low-grade inflammation in the ovary to activate the NLRP3 inflammasome, further inducing a series of pathologies including ovarian GC pyroptotic death, follicular dysfunction and ovarian interstitial cell fibrosis.	hyperandrogen	28-41	NLR family, pyrin domain containing 3	Mus musculus	113-118
32682928-10	2020	Furthermore, the baicalin-provided NLRP3 inflammasome activation and promotion on liver regeneration after APAP-induced liver injury in wild-type mice were diminished in Nrf2 knockout mice.	baicalin	17-25	NLR family, pyrin domain containing 3	Mus musculus	35-40
32682928-10	2020	Furthermore, the baicalin-provided NLRP3 inflammasome activation and promotion on liver regeneration after APAP-induced liver injury in wild-type mice were diminished in Nrf2 knockout mice.	4-amino-N-acetyl-N-methylaniline	107-111	NLR family, pyrin domain containing 3	Mus musculus	35-40
32682928-11	2020	In conclusion, baicalin promoted liver regeneration after APAP-induced acute liver injury in mice via inducing Nrf2 accumulation in cytoplasm that led to NLRP3 inflammasome activation, and then caused the increased expression of IL-18, which induced hepatocytes proliferation.	baicalin	15-23	NLR family, pyrin domain containing 3	Mus musculus	154-159
33328988-7	2020	We further demonstrated that the mitochondrial protector diazoxide was able to reduce NLRP3 upregulation in a post-operative treatment paradigm.	Diazoxide	57-66	NLR family, pyrin domain containing 3	Mus musculus	86-91
33328988-9	2020	Blockade of NLRP3 activation might contribute to the previously observed anti-inflammatory and neuroprotective effects of diazoxide.	Diazoxide	122-131	NLR family, pyrin domain containing 3	Mus musculus	12-17
32682928-0	2020	Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation.	baicalin	0-8	NLR family, pyrin domain containing 3	Mus musculus	90-95
32682928-0	2020	Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation.	Acetaminophen	43-56	NLR family, pyrin domain containing 3	Mus musculus	90-95
32682928-6	2020	Baicalin induced the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, leading to the increased hepatic expression of interleukin-18 (IL-18) and IL-1beta in APAP-intoxicated mice.	baicalin	0-8	NLR family, pyrin domain containing 3	Mus musculus	80-85
32682928-6	2020	Baicalin induced the activation of NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, leading to the increased hepatic expression of interleukin-18 (IL-18) and IL-1beta in APAP-intoxicated mice.	4-amino-N-acetyl-N-methylaniline	187-191	NLR family, pyrin domain containing 3	Mus musculus	80-85
32682928-8	2020	Moreover, the baicalin-provided promotion on liver regeneration in APAP-intoxicated mice was diminished after the application of NLRP3 inhibitor MCC950 and the recombinant mouse IL-18 binding protein (rmIL-18BP).	baicalin	14-22	NLR family, pyrin domain containing 3	Mus musculus	129-134
32682928-8	2020	Moreover, the baicalin-provided promotion on liver regeneration in APAP-intoxicated mice was diminished after the application of NLRP3 inhibitor MCC950 and the recombinant mouse IL-18 binding protein (rmIL-18BP).	4-amino-N-acetyl-N-methylaniline	67-71	NLR family, pyrin domain containing 3	Mus musculus	129-134
32682928-9	2020	Baicalin induced the cytosolic accumulation of nuclear factor erythroid 2-related factor 2 (Nrf2), and increased the interaction between Nrf2 with Nlrp3, ASC and pro-caspase-1 in livers from APAP-intoxicated mice.	baicalin	0-8	NLR family, pyrin domain containing 3	Mus musculus	147-152
32947010-1	2020	Activation of nucleotide-binding domain leucine-rich repeat containing family pyrin domain containing 3 (NLRP3) inflammasome in Kupffer cells (KCs) contributes significantly to hepatic ischemia/reperfusion (I/R) injury, while the mechanism of how NLRP3 inflammasome is regulated remains less well defined.	Leucine	40-47	NLR family, pyrin domain containing 3	Mus musculus	247-252
33216713-4	2020	Chloride efflux is suggested as an important step in NLRP3 activation, but which chloride channels are involved is still unknown.	Chlorides	0-8	NLR family, pyrin domain containing 3	Mus musculus	53-58
32900490-0	2020	Glycyrrhetinic acid alleviates acute lung injury by PI3K/AKT suppressing macrophagic Nlrp3 inflammasome activation.	Glycyrrhetinic Acid	0-19	NLR family, pyrin domain containing 3	Mus musculus	85-90
32912629-4	2020	We have previously reported that Hcy induces vascular endothelial inflammation accompanied by the increase of high mobility group box-1 protein (HMGB1) and lysosomal cysteine protease cathepsin V in endothelial cells, and other studies have shown that HMGB1 or cathepsins are involved in activation of NLRP3 inflammasome and caspase-1.	Homocysteine	33-36	NLR family, pyrin domain containing 3	Mus musculus	302-307
32900490-10	2020	GA notably attenuated ALI by inhibiting Nlrp3 formation and activation.	Glycyrrhetinic Acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	40-45
32900490-12	2020	These findings indicate that GA ameliorated ALI in mice by suppressing the activation of Nlrp3 inflammasome which may be mediated by ROS-PI3K/AKT pathway.	Glycyrrhetinic Acid	29-31	NLR family, pyrin domain containing 3	Mus musculus	89-94
32900490-12	2020	These findings indicate that GA ameliorated ALI in mice by suppressing the activation of Nlrp3 inflammasome which may be mediated by ROS-PI3K/AKT pathway.	Reactive Oxygen Species	133-136	NLR family, pyrin domain containing 3	Mus musculus	89-94
33203418-15	2020	CONCLUSION: PAS-Na antagonized Mn-induced NLRP3 inflammasome dependent pyroptosis through inhibiting NF-kappaB pathway activation and oxidative stress.	1-naphthylphenylamine	12-18	NLR family, pyrin domain containing 3	Mus musculus	42-47
33294118-8	2020	In addition, the DA neuronal MN9D cell line and microglial BV-2 cell line were employed to explore whether EA-mediated neuroprotection was through an NLRP3-dependent mechanism.	Ellagic Acid	107-109	NLR family, pyrin domain containing 3	Mus musculus	150-155
33202409-2	2021	Our further study demonstrated that colchicine, a therapeutic agent for gout, significantly suppressed NSAID-induced small intestinal damage by inhibiting NLRP3 inflammasome activation in mice.	Colchicine	36-46	NLR family, pyrin domain containing 3	Mus musculus	155-160
33203418-0	2020	Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-kappaB pathway activation and oxidative stress.	sodium para-aminosalicylic acid	0-31	NLR family, pyrin domain containing 3	Mus musculus	59-64
33203418-0	2020	Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-kappaB pathway activation and oxidative stress.	Manganese	41-50	NLR family, pyrin domain containing 3	Mus musculus	59-64
33290264-0	2020	Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation.	tanshinone	0-14	NLR family, pyrin domain containing 3	Mus musculus	57-62
33203418-1	2020	BACKGROUND: The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology of manganese (Mn)-induced neurotoxicity.	Manganese	156-165	NLR family, pyrin domain containing 3	Mus musculus	30-57
33203418-1	2020	BACKGROUND: The activation of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent pyroptosis has been shown to play a vital role in the pathology of manganese (Mn)-induced neurotoxicity.	Manganese	156-165	NLR family, pyrin domain containing 3	Mus musculus	59-64
33203418-4	2020	We hypothesized that PAS-Na might act through NLRP3.	Protactinium	21-25	NLR family, pyrin domain containing 3	Mus musculus	46-51
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	NLR family, pyrin domain containing 3	Mus musculus	144-171
33442380-8	2020	Mechanism studies showed that JC-5411 exerted anti-inflammatory effect through activating Nrf2 signaling and inhibiting NF-kappaB and NLRP3 inflammasome pathway.	phenethyl isothiocyanate	30-37	NLR family, pyrin domain containing 3	Mus musculus	134-139
33202867-4	2020	METHODS: Glycerol-mediated RIAKI was induced in NLRP3 KO and wild-type (WT) mice.	Glycerol	9-17	NLR family, pyrin domain containing 3	Mus musculus	48-53
33202867-9	2020	Following glycerin injection, increases in cleaved caspase-3, poly (ADP-ribose) polymerase (PARP), and a decrease in the glutathione peroxidase 4 (GPX-4) level were observed in the kidneys of mice with RIAKI, and these changes were alleviated in the kidneys of NLRP3 KO mice.	Glycerol	10-18	NLR family, pyrin domain containing 3	Mus musculus	261-266
33202867-13	2020	CONCLUSIONS: NLRP3 depletion ameliorated renal tubular injury in a murine glycerol-induced acute kidney injury (AKI) model.	Glycerol	74-82	NLR family, pyrin domain containing 3	Mus musculus	13-18
33281541-0	2020	Neuroprotective Effect of Oridonin on Traumatic Brain Injury via Inhibiting NLRP3 Inflammasome in Experimental Mice.	oridonin	26-34	NLR family, pyrin domain containing 3	Mus musculus	76-81
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	cardamonin	13-15	NLR family, pyrin domain containing 3	Mus musculus	173-178
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	Acetaminophen	36-40	NLR family, pyrin domain containing 3	Mus musculus	144-171
33364966-7	2020	Furthermore, CD effectively reduced APAP-induced inflammation by inhibiting high mobility group box 1 (HMGB1), toll-like receptor 4 (TLR4), and NOD-like receptor protein 3 (NLRP3) signaling.	Acetaminophen	36-40	NLR family, pyrin domain containing 3	Mus musculus	173-178
33244197-15	2020	Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) and gasdermin D (GSDMD)-N in the CCl4 group was higher than that in the control group, while expression of these proteins in the DHM group was lower than that in the vehicle group.	Carbon Tetrachloride	173-177	NLR family, pyrin domain containing 3	Mus musculus	91-131
33176803-11	2020	Pinocembrin treatment significantly inhibited the formation of NLRP3 inflammasome and infiltration of microglia and enhanced BNIP3-mediated mitophagy in the hippocampus of IH mice.	pinocembrin	0-11	NLR family, pyrin domain containing 3	Mus musculus	63-68
33204133-7	2020	Moreover, ISO decreased biochemical indexes in the serum and inhibited the activation of HMGB1/NLRP3/NF-kappaB signaling in the kidney of db/db model mice.	isomangiferin	10-13	NLR family, pyrin domain containing 3	Mus musculus	95-100
33204133-8	2020	Conclusion: ISO provides protection against renal injury via inhibiting HMGB1/NLRP3/NF-kappaB signaling in a diabetic mouse model.	isomangiferin	12-15	NLR family, pyrin domain containing 3	Mus musculus	78-83
33240089-0	2020	Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly.	evodiamine	0-10	NLR family, pyrin domain containing 3	Mus musculus	90-95
33240089-5	2020	We also observed that evodiamine restrained the formation of the NLRP3 inflammasome by inhibiting the apoptosis-associated speck-like protein oligomerization and caspase-1 activity in THP-1 macrophages.	evodiamine	22-32	NLR family, pyrin domain containing 3	Mus musculus	65-70
33240089-6	2020	Our results demonstrated evodiamine inhibit NLRP3 inflammasome activation via the induction of autophagosome-mediated degradation of inflammasome and the inhibition of NFkappaB pathway, which synergistically contribute to the effect of evodiamine in colitis.	evodiamine	25-35	NLR family, pyrin domain containing 3	Mus musculus	44-49
33240089-6	2020	Our results demonstrated evodiamine inhibit NLRP3 inflammasome activation via the induction of autophagosome-mediated degradation of inflammasome and the inhibition of NFkappaB pathway, which synergistically contribute to the effect of evodiamine in colitis.	evodiamine	236-246	NLR family, pyrin domain containing 3	Mus musculus	44-49
33161415-10	2020	Moreover, ISO induced pyroptosis in the CFs cocultured with cardiomyocytes, and this process was inhibited by disruption of the MNTs with Cyto D or by the NLRP3 inhibitor MCC950 and the caspase-1 inhibitor Z-YVAD-FMK (FMK).	Isoproterenol	10-13	NLR family, pyrin domain containing 3	Mus musculus	155-160
33156491-0	2021	Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway.	Sodium 4-aminosalicylate	0-28	NLR family, pyrin domain containing 3	Mus musculus	102-107
33244197-15	2020	Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR- and pyrin domain-containing 3 (NLRP3) and gasdermin D (GSDMD)-N in the CCl4 group was higher than that in the control group, while expression of these proteins in the DHM group was lower than that in the vehicle group.	Carbon Tetrachloride	173-177	NLR family, pyrin domain containing 3	Mus musculus	133-138
33156491-0	2021	Sodium P-aminosalicylic Acid Inhibits Manganese-Induced Neuroinflammation in BV2 Microglial Cells via NLRP3-CASP1 Inflammasome Pathway.	Manganese	38-47	NLR family, pyrin domain containing 3	Mus musculus	102-107
33244197-16	2020	Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1beta (IL-1beta) in the CCl4 group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1beta was decreased.	Carbon Tetrachloride	170-174	NLR family, pyrin domain containing 3	Mus musculus	117-122
33156491-6	2021	PAS-Na significantly concentration and time dependently inhibited Mn-induced production of NLRP3, CASP1, IL-1beta, and IL-18.	1-naphthylphenylamine	0-6	NLR family, pyrin domain containing 3	Mus musculus	91-96
33244197-16	2020	Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1beta (IL-1beta) in the CCl4 group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1beta was decreased.	Carbon Tetrachloride	170-174	NLR family, pyrin domain containing 3	Mus musculus	265-270
33251225-0	2020	Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFkappaB/ROS Signaling Pathways.	ros	112-115	NLR family, pyrin domain containing 3	Mus musculus	21-26
33135287-9	2020	In addition, the GSDMD pore results in potassium efflux that can activate the NLRP3 inflammasome.	Potassium	39-48	NLR family, pyrin domain containing 3	Mus musculus	78-83
33251225-4	2020	This research aimed to explore the effect of adiponectin on palmitate (PA)-mediated NLRP3 inflammasome activation and its potential molecular mechanisms.	Palmitates	60-69	NLR family, pyrin domain containing 3	Mus musculus	84-89
33251225-4	2020	This research aimed to explore the effect of adiponectin on palmitate (PA)-mediated NLRP3 inflammasome activation and its potential molecular mechanisms.	Palmitates	71-73	NLR family, pyrin domain containing 3	Mus musculus	84-89
33251225-11	2020	Moreover, the expression levels of NLRP3 inflammasome pathway molecules (NFkappaB and ROS) were upregulated, while the phosphorylation levels of AMPK, JNK, and Erk1/2 were downregulated in adiponectin-KO mice compared with wild-type mice.	ros	86-89	NLR family, pyrin domain containing 3	Mus musculus	35-40
33251225-13	2020	Additionally, PA significantly promoted NLRP3 inflammasome activation and complex gene and protein expression in hepatocytes.	Palmitates	14-16	NLR family, pyrin domain containing 3	Mus musculus	40-45
33153475-7	2020	A pharmacological inhibitor of NLRP3 (CY-09) was administered to suppress NLPR3 activation.	CY5.5 cyanine dye	38-43	NLR family, pyrin domain containing 3	Mus musculus	31-36
33251225-16	2020	Adiponectin inhibited PA-mediated NLRP3 inflammasome activation in hepatocytes.	Palmitates	22-24	NLR family, pyrin domain containing 3	Mus musculus	34-39
33153477-8	2020	Finally, the ability of BMAA to activate neuronal innate immunity was quantified by addressing TLRs (Toll-like receptors) expression, p65 NF-kappaB translocation into the nucleus, increased expression of NLRP3 (Nod-like receptor 3), and pro-IL-1beta.	beta-N-methylamino-L-alanine	24-28	NLR family, pyrin domain containing 3	Mus musculus	204-209
32861720-7	2020	Focusing on astrocytes, we found UNC9995 shows a relatively safe concentration range and significantly suppresses astrocytic NLRP3 inflammasome activation induced by lipopolysaccharide plus ATP.	Adenosine Triphosphate	190-193	NLR family, pyrin domain containing 3	Mus musculus	125-130
33153477-12	2020	BMAA treatment also activated neuronal extracellular TLR4 and intracellular TLR3, inducing p65 NF-kappaB translocation into the nucleus and activating the transcription of NLRP3 and pro-IL-1beta.	beta-N-methylamino-L-alanine	0-4	NLR family, pyrin domain containing 3	Mus musculus	172-177
33154451-0	2020	Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity.	Riboflavin	0-10	NLR family, pyrin domain containing 3	Mus musculus	35-40
33154451-0	2020	Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity.	Riboflavin	12-22	NLR family, pyrin domain containing 3	Mus musculus	35-40
33154451-4	2020	In the present study, riboflavin attenuated the indicators of NLRP3 inflammasome activation in macrophages, such as the maturation and secretion of interleukin (IL)-1beta, IL-18, and caspase-1; the formation of Asc pyroptosome; and the cleavage of gasdermin D.	Riboflavin	22-32	NLR family, pyrin domain containing 3	Mus musculus	62-67
33154451-6	2020	Mechanistically, riboflavin prevented mitochondrial perturbations, such as mitochondrial ROS production and mitochondrial DNA release, which trigger the NLRP3 inflammasome assembly.	Riboflavin	17-27	NLR family, pyrin domain containing 3	Mus musculus	153-158
33154451-6	2020	Mechanistically, riboflavin prevented mitochondrial perturbations, such as mitochondrial ROS production and mitochondrial DNA release, which trigger the NLRP3 inflammasome assembly.	ros	89-92	NLR family, pyrin domain containing 3	Mus musculus	153-158
32846198-7	2020	Furthermore, ECH administration alleviated MPTP-triggered microglial activation, thus downregulated the expression and activation of NLRP3 inflammasomes in mice SN, along with the involved proteins including Caspase (CASP)-1 and interleukin-1beta (IL-1beta).	echinacoside	13-16	NLR family, pyrin domain containing 3	Mus musculus	133-138
32846198-8	2020	The inhibition of NLRP3/CASP-1/IL-1beta neuroinflammatory signaling was further confirmed in murine N9 microglia activated by MPP+ insult after ECH treatment in vitro.	mangion-purified polysaccharide (Candida albicans)	126-129	NLR family, pyrin domain containing 3	Mus musculus	18-23
32846198-9	2020	Furthermore, MCC950, a selective inhibitor for NLRP3 activation, reduced the enhancive expression of NLRP3/CASP-1/IL-1beta in MPP+-insulted N9, and also facilitated the inhibition of inflammation synergistically mediated by ECH treatment.	echinacoside	224-227	NLR family, pyrin domain containing 3	Mus musculus	101-106
32980515-2	2020	In this study, rationally designed alkenyl sulfonylurea derivatives were identified as novel, potent and orally bioavailable NLRP3 inhibitors.	alkenyl sulfonylurea	35-55	NLR family, pyrin domain containing 3	Mus musculus	125-130
32846198-0	2020	Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1beta signaling pathway in MPTP-induced Parkinson"s disease model.	echinacoside	0-12	NLR family, pyrin domain containing 3	Mus musculus	57-62
32846198-0	2020	Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1beta signaling pathway in MPTP-induced Parkinson"s disease model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	103-107	NLR family, pyrin domain containing 3	Mus musculus	57-62
33269624-10	2020	Baicalin reduced the expression of NLRP3 inflammasome and suppressed its activation.	baicalin	0-8	NLR family, pyrin domain containing 3	Mus musculus	35-40
32902155-0	2020	Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.	Oxidopamine	43-49	NLR family, pyrin domain containing 3	Mus musculus	105-110
32902155-0	2020	Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.	ros	101-104	NLR family, pyrin domain containing 3	Mus musculus	105-110
32902155-5	2020	Therefore, in this study, we focused on ROS-NLRP3 signal to investigate the mechanism of 6-OHDA-induced apoptosis of dopaminergic neurons MES23.5 and the protective effects of ACP on dopaminergic neurons.	ros	40-43	NLR family, pyrin domain containing 3	Mus musculus	44-49
32902155-5	2020	Therefore, in this study, we focused on ROS-NLRP3 signal to investigate the mechanism of 6-OHDA-induced apoptosis of dopaminergic neurons MES23.5 and the protective effects of ACP on dopaminergic neurons.	Oxidopamine	89-95	NLR family, pyrin domain containing 3	Mus musculus	44-49
32902155-6	2020	RESULT: 6-OHDA could further activate the expression of inflammasome NLRP3 by inducing ROS, thereby resulting in apoptosis of MES23.5 cells.	Oxidopamine	8-14	NLR family, pyrin domain containing 3	Mus musculus	69-74
32902155-6	2020	RESULT: 6-OHDA could further activate the expression of inflammasome NLRP3 by inducing ROS, thereby resulting in apoptosis of MES23.5 cells.	ros	87-90	NLR family, pyrin domain containing 3	Mus musculus	69-74
32902155-7	2020	ACP could inhibit the expression of ROS-NLRP3 induced by 6-OHDA, exerting a protective role in MES23.5 cells.	acp	0-3	NLR family, pyrin domain containing 3	Mus musculus	40-45
32902155-7	2020	ACP could inhibit the expression of ROS-NLRP3 induced by 6-OHDA, exerting a protective role in MES23.5 cells.	Oxidopamine	57-63	NLR family, pyrin domain containing 3	Mus musculus	40-45
32902155-8	2020	Animal experiments also confirmed that ACP intervention could reduce the activation level of ROS-NLRP3 in the substantia nigra-striatum and improve the exercise capacity of PD mice.	acp	39-42	NLR family, pyrin domain containing 3	Mus musculus	97-102
32902155-8	2020	Animal experiments also confirmed that ACP intervention could reduce the activation level of ROS-NLRP3 in the substantia nigra-striatum and improve the exercise capacity of PD mice.	ros	93-96	NLR family, pyrin domain containing 3	Mus musculus	97-102
32902155-9	2020	CONCLUSION: Our study validated that 6-OHDA could induce apoptosis of dopaminergic neurons via ROS-NLRP3 activation.	Oxidopamine	37-43	NLR family, pyrin domain containing 3	Mus musculus	99-104
32902155-9	2020	CONCLUSION: Our study validated that 6-OHDA could induce apoptosis of dopaminergic neurons via ROS-NLRP3 activation.	ros	95-98	NLR family, pyrin domain containing 3	Mus musculus	99-104
33269624-3	2020	The inhibition of NLRP3 inflammasome activation by baicalin has also been described.	baicalin	51-59	NLR family, pyrin domain containing 3	Mus musculus	18-23
33269624-4	2020	Therefore, the effects of baicalin on NLRP3 inflammasome activation and atherosclerosis were evaluated in present study.	baicalin	26-34	NLR family, pyrin domain containing 3	Mus musculus	38-43
33269624-12	2020	Silencing NLRP3 resulted in decreased production of IL-1, IL-18, mitochondria ROS, total ROS, ICAM-1, and VCAM-1, and inhibition of NLRP3 inflammasome activation.	Reactive Oxygen Species	78-81	NLR family, pyrin domain containing 3	Mus musculus	10-15
33269624-12	2020	Silencing NLRP3 resulted in decreased production of IL-1, IL-18, mitochondria ROS, total ROS, ICAM-1, and VCAM-1, and inhibition of NLRP3 inflammasome activation.	Reactive Oxygen Species	89-92	NLR family, pyrin domain containing 3	Mus musculus	10-15
33269624-13	2020	CONCLUSION: Baicalin ameliorated atherosclerosis by inhibiting NLRP3 inflammasome.	baicalin	12-20	NLR family, pyrin domain containing 3	Mus musculus	63-68
33182019-7	2020	We found that treatment with 5MTP contributed to decreased activation of pro-inflammatory microglia and reduced the generation of inflammatory cytokines, including TNF-alpha, IL-1beta, IL-6 and IL-18, by negative regulation of the p38-MAPK signaling pathway and NLRP3/caspase-1 expression.	5-methoxytryptophan	29-33	NLR family, pyrin domain containing 3	Mus musculus	262-267
32870322-0	2020	Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-kappaB-NLRP3 inflammation activation.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	103-108
32870322-6	2020	We further found that metformin significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central hippocampus.	Metformin	22-31	NLR family, pyrin domain containing 3	Mus musculus	57-62
32870322-7	2020	Our findings reveal that metformin confers an antidepressant effect partly through inhibition of peripheral and central NLRP3 inflammasome activation.	Metformin	25-34	NLR family, pyrin domain containing 3	Mus musculus	120-125
32870322-8	2020	In light of metformin favorable properties, it should be evaluated in the treatment of depression and related neurologic disorders characterized by NLRP3 inflammasome activation.	Metformin	12-21	NLR family, pyrin domain containing 3	Mus musculus	148-153
33182064-0	2020	Amifostine ameliorates induction of experimental autoimmune encephalomyelitis: Effect on reactive oxygen species/NLRP3 pathway.	Amifostine	0-10	NLR family, pyrin domain containing 3	Mus musculus	113-118
33182028-7	2020	Moreover, both in vivo and in vitro data showed that A-68930-induced DRD1 activation significantly inhibited NLRP3 inflammasome-dependent neuroinflammation induced by Abeta1-42, and this effect may be mediated by the activation of AMPK/autophagy signaling pathway, which enhanced NLRP3 inflammasome degradation and thus decreased the secretion of IL-1beta and IL-18.	A 68930	53-60	NLR family, pyrin domain containing 3	Mus musculus	109-114
33182028-7	2020	Moreover, both in vivo and in vitro data showed that A-68930-induced DRD1 activation significantly inhibited NLRP3 inflammasome-dependent neuroinflammation induced by Abeta1-42, and this effect may be mediated by the activation of AMPK/autophagy signaling pathway, which enhanced NLRP3 inflammasome degradation and thus decreased the secretion of IL-1beta and IL-18.	A 68930	53-60	NLR family, pyrin domain containing 3	Mus musculus	280-285
33182069-8	2020	Importantly, LQ inhibited the expression of cleaved caspase-8 and the downstream NLRP3 inflammasome and IL-1beta.	laquinimod	13-15	NLR family, pyrin domain containing 3	Mus musculus	81-86
32977368-8	2020	However, when corticosteroids intervened the LPS-primed macrophages, it also negatively regulated NLRP3-inflammasome activation through suppressing mitochondrial reactive oxygen species (mtROS) production.	Oxygen	171-177	NLR family, pyrin domain containing 3	Mus musculus	98-103
32965793-6	2020	In vitro, Lico A could reduce the expression of NLRP3, apoptosis-associated speck-like protein (ASC), Gasdermin D (GSDMD), caspase-1, interleukin-1beta (IL-1beta) and IL-18, which indicated that Lico A attenuates LPS-induced chondrocytes pyroptosis.	licochalcone A	10-16	NLR family, pyrin domain containing 3	Mus musculus	48-53
33192124-2	2020	Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation.	Ginsenosides	0-12	NLR family, pyrin domain containing 3	Mus musculus	74-79
32965793-8	2020	Meanwhile, we found that Lico A inhibits NLRP3 inflammasome via nuclear factor erythroid-2-related factor 2 (Nrf2)/haeme oxygenase-1(HO-1)/nuclear factor kappa-B (NF-kappaB) axis.	licochalcone A	25-31	NLR family, pyrin domain containing 3	Mus musculus	41-46
33105536-0	2020	Effect of Pioglitazone on Perihematomal Edema in Intracerebral Hemorrhage Mouse Model by Regulating NLRP3 Expression and Energy Metabolism.	Pioglitazone	10-22	NLR family, pyrin domain containing 3	Mus musculus	100-105
33105536-11	2020	Expression levels of NLRP3 in the ICH model treated with pioglitazone were decreased more than those of the control mice on days 3 and 7.	Pioglitazone	57-69	NLR family, pyrin domain containing 3	Mus musculus	21-26
33105536-15	2020	Pioglitazone decreased NLRP3-related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in the ICH mice model.	Pioglitazone	0-12	NLR family, pyrin domain containing 3	Mus musculus	23-28
33105536-15	2020	Pioglitazone decreased NLRP3-related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in the ICH mice model.	Lactic Acid	116-123	NLR family, pyrin domain containing 3	Mus musculus	23-28
33182050-5	2020	In vitro studies showed that IL-6 directly induced NLRP3 inflammasome activation via cathepsin B (CTSB) in the presence of ATP.	Adenosine Triphosphate	123-126	NLR family, pyrin domain containing 3	Mus musculus	51-56
33182050-6	2020	In addition, S100A9 induced by ATP stimulation promoted the interaction of CTSB and NLRP3 to activate the NLRP3 inflammasome.	Adenosine Triphosphate	31-34	NLR family, pyrin domain containing 3	Mus musculus	84-89
33182050-6	2020	In addition, S100A9 induced by ATP stimulation promoted the interaction of CTSB and NLRP3 to activate the NLRP3 inflammasome.	Adenosine Triphosphate	31-34	NLR family, pyrin domain containing 3	Mus musculus	106-111
33192124-2	2020	Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation.	Ginsenosides	0-12	NLR family, pyrin domain containing 3	Mus musculus	208-213
33192124-2	2020	Ginsenosides, saponin molecules of RGE, selectively inhibit activation of NLRP3 and AIM2 inflammasomes, while non-saponin molecules of RGE upregulate inflammasome components associated with the initiation of NLRP3 inflammasome activation.	Saponins	14-21	NLR family, pyrin domain containing 3	Mus musculus	74-79
32949661-0	2020	OXYGEN EXPOSURE IN EARLY LIFE ACTIVATES NLRP3 INFLAMMASOME IN MOUSE BRAIN.	Oxygen	0-6	NLR family, pyrin domain containing 3	Mus musculus	40-45
33128438-5	2020	Primary mouse alveolar macrophages and cultured murine macrophages exposed to CFH (0-1 mg/ml) for 24 hr demonstrated robust upregulation of the NLRP3 inflammasome components NLRP3, caspase-1, and caspase-11.	hexafluoroisopropanol	78-81	NLR family, pyrin domain containing 3	Mus musculus	144-149
32882398-7	2020	Minocycline also prevented expression of the hippocampal NLRP3 inflammasome, indicating that microglia might be the primary contributor to SI-induced hippocampal NLRP3 inflammasome activation.	Minocycline	0-11	NLR family, pyrin domain containing 3	Mus musculus	57-62
32882398-7	2020	Minocycline also prevented expression of the hippocampal NLRP3 inflammasome, indicating that microglia might be the primary contributor to SI-induced hippocampal NLRP3 inflammasome activation.	Minocycline	0-11	NLR family, pyrin domain containing 3	Mus musculus	162-167
33128438-5	2020	Primary mouse alveolar macrophages and cultured murine macrophages exposed to CFH (0-1 mg/ml) for 24 hr demonstrated robust upregulation of the NLRP3 inflammasome components NLRP3, caspase-1, and caspase-11.	hexafluoroisopropanol	78-81	NLR family, pyrin domain containing 3	Mus musculus	174-179
33128438-9	2020	Together, these data demonstrate that CFH can stimulate the NLRP3 inflammasome in macrophages and that this pathway may be important in the pathogenesis of CFH-induced acute lung injury.	hexafluoroisopropanol	38-41	NLR family, pyrin domain containing 3	Mus musculus	60-65
33114221-0	2020	Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation In Vivo and In Vitro.	Auranofin	0-9	NLR family, pyrin domain containing 3	Mus musculus	93-98
32569717-7	2020	AIM OF THE STUDY: To investigate the protective effect of PS against cadmium-induced testicular injury in mice via the TXNIP-NLRP3-Caspase-1 and CytC-Caspase-9-Caspase-3 pathway.	ps	58-60	NLR family, pyrin domain containing 3	Mus musculus	125-130
32861708-6	2020	Downregulation of the CPT1-FAO-acetyl-coenzyme A (acetyl-CoA)-acetylated alpha-tubulin pathway was observed to inhibit the effect of arctigenin on NLRP3 inflammasome assembly, as confirmed by CPT1 overexpression.	fao-acetyl-coenzyme a	27-48	NLR family, pyrin domain containing 3	Mus musculus	147-152
32861708-6	2020	Downregulation of the CPT1-FAO-acetyl-coenzyme A (acetyl-CoA)-acetylated alpha-tubulin pathway was observed to inhibit the effect of arctigenin on NLRP3 inflammasome assembly, as confirmed by CPT1 overexpression.	Acetyl Coenzyme A	50-60	NLR family, pyrin domain containing 3	Mus musculus	147-152
32861708-6	2020	Downregulation of the CPT1-FAO-acetyl-coenzyme A (acetyl-CoA)-acetylated alpha-tubulin pathway was observed to inhibit the effect of arctigenin on NLRP3 inflammasome assembly, as confirmed by CPT1 overexpression.	arctigenin	133-143	NLR family, pyrin domain containing 3	Mus musculus	147-152
32861708-7	2020	Lastly, arctigenin was shown to inhibit NLRP3 inflammasome activation and improve CAC in mice, and the effect was significantly diminished by the overexpression of adeno-associated virus (AAV)9-CPT1.	arctigenin	8-18	NLR family, pyrin domain containing 3	Mus musculus	40-45
33114221-8	2020	In addition, auranofin suppressed the expressions of interleukin (IL)-1beta, IL-18, caspase-1, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) in the liver tissue.	Auranofin	13-22	NLR family, pyrin domain containing 3	Mus musculus	155-160
33114221-11	2020	Auranofin could significantly inhibit LPS- and PA-induced inflammatory activity including nitric oxide and NLRP3 inflammasome-mediated cytokines.	Auranofin	0-9	NLR family, pyrin domain containing 3	Mus musculus	107-112
33097834-4	2021	USP19 inhibited NLRP3 inflammasome activation by increasing autophagy flux and decreasing the generation of mitochondrial reactive oxygen species.	Reactive Oxygen Species	122-145	NLR family, pyrin domain containing 3	Mus musculus	16-21
33114221-12	2020	The results of this study demonstrate that auranofin treatment inhibits the characteristics of NAFLD through the inhibition of NLRP3 inflammasome.	Auranofin	43-52	NLR family, pyrin domain containing 3	Mus musculus	127-132
33093455-0	2020	Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1beta/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model.	Oxygen	154-160	NLR family, pyrin domain containing 3	Mus musculus	15-20
33078870-0	2020	Chlorogenic Acid Suppresses miR-155 and Ameliorates Ulcerative Colitis Through the NF-kappaB/NLRP3 inflammasome Pathway.	Chlorogenic Acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	93-98
33192525-11	2020	Thus, scutellarin might alleviate HN progression via a mechanism involved in CCN1 regulation on NLRP3 inflammasome activation.	scutellarin	6-17	NLR family, pyrin domain containing 3	Mus musculus	96-101
33093455-1	2020	Activation of the nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome plays an important role in ocular neovascularization.	Leucine	44-51	NLR family, pyrin domain containing 3	Mus musculus	104-109
33087357-3	2020	Mice with macrophage-specific CD1d1 deficiency (LymCD1d1-/- ) acquire resistance to dextran sodium sulfate (DSS)-induced colitis, attributing to the transcriptional inhibition of NLRP3 inflammasome components.	dextran sodium sulfate	84-106	NLR family, pyrin domain containing 3	Mus musculus	179-184
33087357-3	2020	Mice with macrophage-specific CD1d1 deficiency (LymCD1d1-/- ) acquire resistance to dextran sodium sulfate (DSS)-induced colitis, attributing to the transcriptional inhibition of NLRP3 inflammasome components.	dss	108-111	NLR family, pyrin domain containing 3	Mus musculus	179-184
33078870-3	2020	METHODS AND RESULTS: In this study, we used the NLRP3 inflammasome model with LPS/ATP-induced RAW264.7 cells in vitro and dextran-sulfate-sodium-induced colitis in mice to evaluate the effect of CGA on NLRP3 inflammasome-related signaling.	Adenosine Triphosphate	82-85	NLR family, pyrin domain containing 3	Mus musculus	48-53
33078870-7	2020	CGA exposure in LPS/ATP-stimulated RAW264.7 cells led to a decrease in p-NK-kappaB and NLRP3 inflammasome-related proteins, which was dependent on the downregulation of miR-155 expression.	Adenosine Triphosphate	20-23	NLR family, pyrin domain containing 3	Mus musculus	87-92
33066442-5	2020	The activation of the NLRP3 inflammasome was determined by detecting the activity of caspase-1 and the production of Interleukin 1beta (IL-1beta) in Lipopolysaccharide (LPS) and ATP-stimulated Tamm-Horsfall Protein 1 (THP-1) macrophages, while the production of IL-6 was studied in LPS-stimulated RAW264.7 mouse macrophages.	Adenosine Triphosphate	178-181	NLR family, pyrin domain containing 3	Mus musculus	22-27
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Uric Acid	22-31	NLR family, pyrin domain containing 3	Mus musculus	65-116
33132912-0	2020	alpha-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation.	alpha-cyperone	0-14	NLR family, pyrin domain containing 3	Mus musculus	113-118
33132912-0	2020	alpha-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation.	ros	100-103	NLR family, pyrin domain containing 3	Mus musculus	113-118
33132912-6	2020	NLRP3 inflammasome related proteins including NLRP3, ASC, Caspase-1, IL-1beta, IL-18 and GSDMD-N were downregulated after Cy administration.	alpha-cyperone	122-124	NLR family, pyrin domain containing 3	Mus musculus	0-5
33132912-6	2020	NLRP3 inflammasome related proteins including NLRP3, ASC, Caspase-1, IL-1beta, IL-18 and GSDMD-N were downregulated after Cy administration.	alpha-cyperone	122-124	NLR family, pyrin domain containing 3	Mus musculus	46-51
33134248-10	2020	It was found that Nrf2 was significantly activated in the COS@SiO2 treatment group, and the expressions of NF-kappaB and the NLRP3 inflammasome were notably decreased.	carbonyl sulfide	58-61	NLR family, pyrin domain containing 3	Mus musculus	125-130
33134248-10	2020	It was found that Nrf2 was significantly activated in the COS@SiO2 treatment group, and the expressions of NF-kappaB and the NLRP3 inflammasome were notably decreased.	Silicon Dioxide	62-66	NLR family, pyrin domain containing 3	Mus musculus	125-130
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Reactive Oxygen Species	204-207	NLR family, pyrin domain containing 3	Mus musculus	65-116
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Reactive Oxygen Species	204-207	NLR family, pyrin domain containing 3	Mus musculus	118-123
33134248-12	2020	This demonstrated that porous COS@SiO2 nanocomposites activate the Nrf2 signaling pathway to inhibit oxidative stress and reduce the expression of NF-kappaB and the NLRP3 inflammasome and the release of inflammatory factors, thus blocking the systemic inflammatory response and ultimately ameliorating SAP and associated lung injury.	carbonyl sulfide	30-33	NLR family, pyrin domain containing 3	Mus musculus	165-170
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Uric Acid	22-31	NLR family, pyrin domain containing 3	Mus musculus	118-123
33134248-12	2020	This demonstrated that porous COS@SiO2 nanocomposites activate the Nrf2 signaling pathway to inhibit oxidative stress and reduce the expression of NF-kappaB and the NLRP3 inflammasome and the release of inflammatory factors, thus blocking the systemic inflammatory response and ultimately ameliorating SAP and associated lung injury.	Silicon Dioxide	34-38	NLR family, pyrin domain containing 3	Mus musculus	165-170
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Reactive Oxygen Species	179-202	NLR family, pyrin domain containing 3	Mus musculus	65-116
33117389-9	2020	In adult UUO, soluble uric acid is upregulated and activates the NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome, which promotes fibrosis, apoptosis, and reactive oxygen species (ROS) injury.	Reactive Oxygen Species	179-202	NLR family, pyrin domain containing 3	Mus musculus	118-123
32608058-8	2020	We show that inhibition of BTK reduces activation of NF-kappaB and the NLRP3 inflammasome specifically in primary murine and human macrophages; which are the primary target of ibrutinib in vivo in the setting of metabolic inflammation.	ibrutinib	176-185	NLR family, pyrin domain containing 3	Mus musculus	71-76
33017381-0	2020	The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-kappaB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways.	O(1)-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-phenylglycine ethyl ester	31-34	NLR family, pyrin domain containing 3	Mus musculus	121-157
33017381-0	2020	The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-kappaB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways.	O(1)-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-phenylglycine ethyl ester	31-34	NLR family, pyrin domain containing 3	Mus musculus	159-164
33017381-8	2020	Furthermore, C16 significantly inhibited pyroptosis during AKI, as evidenced by decreased renal levels of apoptosis-associated speck-like protein; NACHT, LRR, NLR Family Pyrin Domain-Containing 3; caspase-1; interleukin (IL)-1ss; and IL-18.	O(1)-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-phenylglycine ethyl ester	13-16	NLR family, pyrin domain containing 3	Mus musculus	159-195
32768195-8	2020	Also, GdCI3 increased the level of CaMKII phosphorylation, and upregulated expression of NLRP3, cleaved caspase-1, and IL-1beta, which were attenuated by NPS-2143.	gdci3	6-11	NLR family, pyrin domain containing 3	Mus musculus	89-94
32768195-9	2020	Besides, CaMKII inhibitor KN-93 down-regulated the upregulated expression of NLRP3, cleaved caspase-1, and IL-1beta induced by GdCI3.	KN 93	26-31	NLR family, pyrin domain containing 3	Mus musculus	77-82
32768883-0	2020	Lychee seed polyphenol inhibits Abeta-induced activation of NLRP3 inflammasome via the LRP1/AMPK mediated autophagy induction.	Polyphenols	12-22	NLR family, pyrin domain containing 3	Mus musculus	60-65
32674019-6	2020	Furthermore, we found ROS could regulate the intracellular Ca2+ level, expression of the Transient Receptor Potential Melastatin 2 (TRPM2), NLRP3 and its downstream inflammatory factors in vivo.	Reactive Oxygen Species	22-25	NLR family, pyrin domain containing 3	Mus musculus	140-145
32674019-7	2020	In vitro experiments with A549 cells and primary type II alveolar epithelium cells (SD cells) showed that ROS induced by PM2.5 exposure could mediate intracellular Ca2+ mobilization via TRPM2, with a subsequent activation of NLRP3.	Reactive Oxygen Species	106-109	NLR family, pyrin domain containing 3	Mus musculus	225-230
32674019-8	2020	In our present study, we demonstrated the contribution of the ROS-TRPM2-Ca2+-NLRP3 pathway in PM2.5-induced acute lung injury and offered a potential therapeutical target valid for related pathology.	Reactive Oxygen Species	62-65	NLR family, pyrin domain containing 3	Mus musculus	77-82
32607760-4	2020	The NLRP3 inflammasome was activated in the myocardium of Dox-treating (5 mg/kg, once every other day, cumulative dosage to 15 mg/kg and sacrificed after 2 days of last Dox injection) C57BL/6 mice as shown by the up-regulation of NLRP3 and Caspase-1 p20.	Doxorubicin	58-61	NLR family, pyrin domain containing 3	Mus musculus	4-9
32607760-4	2020	The NLRP3 inflammasome was activated in the myocardium of Dox-treating (5 mg/kg, once every other day, cumulative dosage to 15 mg/kg and sacrificed after 2 days of last Dox injection) C57BL/6 mice as shown by the up-regulation of NLRP3 and Caspase-1 p20.	Doxorubicin	58-61	NLR family, pyrin domain containing 3	Mus musculus	230-235
32607760-4	2020	The NLRP3 inflammasome was activated in the myocardium of Dox-treating (5 mg/kg, once every other day, cumulative dosage to 15 mg/kg and sacrificed after 2 days of last Dox injection) C57BL/6 mice as shown by the up-regulation of NLRP3 and Caspase-1 p20.	Doxorubicin	169-172	NLR family, pyrin domain containing 3	Mus musculus	4-9
32444995-0	2020	Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice.	sacubitril and valsartan sodium hydrate drug combination	14-24	NLR family, pyrin domain containing 3	Mus musculus	93-98
32444995-0	2020	Protection of Sacubitril/Valsartan against Pathological Cardiac Remodeling by Inhibiting the NLRP3 Inflammasome after Relief of Pressure Overload in Mice.	Valsartan	25-34	NLR family, pyrin domain containing 3	Mus musculus	93-98
32607763-8	2020	And ROS stimulation activated the NLRP3 inflammasome which was inhibited by thioredoxin-1.	ros	4-7	NLR family, pyrin domain containing 3	Mus musculus	34-39
32444995-8	2020	Finally, our data indicated that Sac/Val treatment could significantly suppress NF-kappaB signaling and NLRP3 inflammasome activation in mice after relief of pressure overload.	Valine	37-40	NLR family, pyrin domain containing 3	Mus musculus	104-109
32444995-9	2020	CONCLUSION: Sac/Val exerted its beneficial effects to prevent maladaptive cardiac fibrosis and dysfunction in mice following pressure unloading, which was at least partly due to the inhibition of NLRP3 inflammasome activation.	Valine	16-19	NLR family, pyrin domain containing 3	Mus musculus	196-201
32654189-7	2020	Tissue NLRP3 levels were 80% higher in the DCD-WT group compared to the CBD-WT group.	dcd	43-46	NLR family, pyrin domain containing 3	Mus musculus	7-12
32654189-7	2020	Tissue NLRP3 levels were 80% higher in the DCD-WT group compared to the CBD-WT group.	Cannabidiol	72-75	NLR family, pyrin domain containing 3	Mus musculus	7-12
32750449-0	2020	Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	123-128
32738376-0	2020	Melatonin induced suppression of ER stress and mitochondrial dysfunction inhibited NLRP3 inflammasome activation in COPD mice.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	83-88
32738376-6	2020	Besides, Cs induced endoplasmic reticulum (ER) stress and mitochondrial dysfunctions causing the activation of NLRP3 inflammasome.	Cesium	9-11	NLR family, pyrin domain containing 3	Mus musculus	111-116
31820078-8	2020	10-HDA inhibited the activation of the TNF-alpha/NF-kappaB axis and NLRP3 inflammasome-IL-1beta pathway, which may be the anti-neuroinflammatory mechanism of 10-HDA.	10-hydroxy-2-decenoic acid	0-6	NLR family, pyrin domain containing 3	Mus musculus	68-73
31820078-8	2020	10-HDA inhibited the activation of the TNF-alpha/NF-kappaB axis and NLRP3 inflammasome-IL-1beta pathway, which may be the anti-neuroinflammatory mechanism of 10-HDA.	10-hydroxy-2-decenoic acid	158-164	NLR family, pyrin domain containing 3	Mus musculus	68-73
31820078-11	2020	Inhibition of FOXO1 and autophagy using chemical inhibitors markedly blunted the effect of 10-HDA on the TNF-alpha pathway and NLRP3 inflammasome-IL-1beta pathway, indicating that 10-HDA alleviates neuroinflammation in BV-2 cells by modulating FOXO1-mediated autophagy.	10-hydroxy-2-decenoic acid	180-186	NLR family, pyrin domain containing 3	Mus musculus	127-132
32813287-0	2020	Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-kappaB/NLRP3 inflammasome and sirtuin 1/autophagy axis.	honokiol	65-73	NLR family, pyrin domain containing 3	Mus musculus	134-139
32750449-8	2020	Moreover, we found that GTPs inhibited Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasomes and increased nuclear factor erythroid 2-related factor 2 (Nrf2) pathways in the liver tissues.	gtps	24-28	NLR family, pyrin domain containing 3	Mus musculus	92-97
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	SI-2 hydrochloride	94-112	NLR family, pyrin domain containing 3	Mus musculus	230-235
32705396-9	2020	Therefore, these findings strongly indicate the anti-inflammatory properties of melatonin that may suppress ROS-NLRP3 inflammasome activation and protect HT22 cells against apoptosis by inhibiting the ROS-mediated p53-dependent mitochondrial apoptotic pathway.	Melatonin	80-89	NLR family, pyrin domain containing 3	Mus musculus	112-117
32705396-9	2020	Therefore, these findings strongly indicate the anti-inflammatory properties of melatonin that may suppress ROS-NLRP3 inflammasome activation and protect HT22 cells against apoptosis by inhibiting the ROS-mediated p53-dependent mitochondrial apoptotic pathway.	Reactive Oxygen Species	108-111	NLR family, pyrin domain containing 3	Mus musculus	112-117
32910484-6	2020	Melatonin inhibited neuronal pyroptosis and excessive autophagy, as evidenced by decreased levels of NLRP3, cleaved caspase-1, GSDMD-N, IL-1beta, LC3, Beclin1, and ATG12 both in vivo and in vitro.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	101-106
32705396-5	2020	Melatonin treatment attenuated the expression of IL-1beta, IL-18, cleaved caspase-1, and NLRP3 and decreased the production of reactive oxygen species (ROS), revealing its inhibitory effects against ROS-NLRP3 inflammasome activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	89-94
32705396-5	2020	Melatonin treatment attenuated the expression of IL-1beta, IL-18, cleaved caspase-1, and NLRP3 and decreased the production of reactive oxygen species (ROS), revealing its inhibitory effects against ROS-NLRP3 inflammasome activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	203-208
32705396-5	2020	Melatonin treatment attenuated the expression of IL-1beta, IL-18, cleaved caspase-1, and NLRP3 and decreased the production of reactive oxygen species (ROS), revealing its inhibitory effects against ROS-NLRP3 inflammasome activation.	Reactive Oxygen Species	199-202	NLR family, pyrin domain containing 3	Mus musculus	203-208
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	SI-2	94-98	NLR family, pyrin domain containing 3	Mus musculus	230-235
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	NLR family, pyrin domain containing 3	Mus musculus	230-235
32736194-4	2020	In this study, by searching for kinds of lysine acetyltransferases inhibitors, we showed that SI-2 hydrochloride (SI-2), a specific inhibitor of lysine acetyltransferase KAT13B (lysine acetyltransferases 13B), specifically blocks NLRP3 inflammasome activation both in mice in vivo and in human cells ex vivo.	Lysine	145-151	NLR family, pyrin domain containing 3	Mus musculus	230-235
32115713-0	2020	Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.	Glucose	0-7	NLR family, pyrin domain containing 3	Mus musculus	34-39
32115713-10	2020	In vivo experiments further revealed that IL-1beta production was increased in LPS-primed mice exposed to hypoxia (9.5% O2 ), which was prevented by a deficiency of NLRP3, an apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1.	Oxygen	120-122	NLR family, pyrin domain containing 3	Mus musculus	165-170
32115713-4	2020	Severe hypoxia (0.1% O2 ) induced the processing of pro-IL-1beta, pro-caspase-1, and gasdermin D, as well as the release of IL-1beta and lactate dehydrogenase in lipopolysaccharide (LPS)-primed murine macrophages, indicating that hypoxia induces NLRP3 inflammasome-driven inflammation and pyroptosis.	Oxygen	21-23	NLR family, pyrin domain containing 3	Mus musculus	246-251
32976511-9	2020	In summary, we revealed that lentinan was a novel adjuvant against T. spiralis infection via NLRP3.	Lentinan	29-37	NLR family, pyrin domain containing 3	Mus musculus	93-98
33000581-4	2020	Cytokines, NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome related protein including caspase-associated recruitment domain (CARD) domain Apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC), caspase-1 and NOD-like receptor family, pyrin domain containing 3 (NLRP3), and reactive oxygen species were simultaneously investigated.	Oxygen	335-341	NLR family, pyrin domain containing 3	Mus musculus	63-68
32886103-6	2020	It is noting that in response to oxLDL challenge, piceatannol abated the pyroptosis in RAW264.7 cells, with a decreased expression of caspase1, GSDMD, IL-18, IL-1b and NLRP3.	3,3',4,5'-tetrahydroxystilbene	50-61	NLR family, pyrin domain containing 3	Mus musculus	168-173
32726591-0	2020	Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia.	beta-amyloid	0-12	NLR family, pyrin domain containing 3	Mus musculus	23-28
32726591-16	2020	Pharmacological inhibition of TLR4 by CLI-095 abolished Abeta1-42-induced NLRP3 inflammasome activation, which curbed the development of inflammation and exerted protective effect on HT-22 neurons.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	38-45	NLR family, pyrin domain containing 3	Mus musculus	74-79
32726591-17	2020	Furthermore, the inhibitory effects of CLI-095 on Abeta1-42-induced inflammation were reversed by NLRP3 activator ATP.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	39-46	NLR family, pyrin domain containing 3	Mus musculus	98-103
32726591-17	2020	Furthermore, the inhibitory effects of CLI-095 on Abeta1-42-induced inflammation were reversed by NLRP3 activator ATP.	Adenosine Triphosphate	114-117	NLR family, pyrin domain containing 3	Mus musculus	98-103
33101273-2	2020	Reactive oxygen species have been implicated in NLRP3 inflammasome activation.	Oxygen	9-15	NLR family, pyrin domain containing 3	Mus musculus	48-53
33101273-4	2020	Thus, the major aim of the present study was to address the role of PKR and the oxidant, peroxynitrite, in the two-tiered function of the NLRP3 inflammasome (priming and activation).	Peroxynitrous Acid	89-102	NLR family, pyrin domain containing 3	Mus musculus	138-143
33101273-9	2020	In a similar fashion, a peroxynitrite decomposition catalyst (Fe-TPPS) prevented both the priming and activation of the NLRP3 inflammasome.	Peroxynitrous Acid	24-37	NLR family, pyrin domain containing 3	Mus musculus	120-125
33101273-9	2020	In a similar fashion, a peroxynitrite decomposition catalyst (Fe-TPPS) prevented both the priming and activation of the NLRP3 inflammasome.	fe-tpps	62-69	NLR family, pyrin domain containing 3	Mus musculus	120-125
33101273-11	2020	Conclusion: Our results indicate that peroxynitrite-/PKR pathway modulates priming and activation of NLRP3 inflammasome in LPS/ATP challenged cardiac fibroblasts.	Peroxynitrous Acid	38-51	NLR family, pyrin domain containing 3	Mus musculus	101-106
33101273-11	2020	Conclusion: Our results indicate that peroxynitrite-/PKR pathway modulates priming and activation of NLRP3 inflammasome in LPS/ATP challenged cardiac fibroblasts.	Adenosine Triphosphate	127-130	NLR family, pyrin domain containing 3	Mus musculus	101-106
32966239-6	2020	We found that endothelia-specific NLRP3-depletion significantly attenuated AS severity in mice treated with HFD, likely through reduced apoptotic death of endothelial cells and production of ROS.	Reactive Oxygen Species	191-194	NLR family, pyrin domain containing 3	Mus musculus	34-39
32595041-0	2020	EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages.	Uric Acid	81-97	NLR family, pyrin domain containing 3	Mus musculus	18-23
33061523-17	2020	Conclusion: This study demonstrates that the NLRP3 inflammasome in microglia plays a crucial role in morphine tolerance and that both TLR4- and P2X7R-dependent pathways are required for NLRP3 inflammasome activation over the course of the development of morphine-induced tolerance.	Morphine	254-262	NLR family, pyrin domain containing 3	Mus musculus	186-191
32595041-9	2020	Silencing Eps8 had no effect on the basal expression of p46/p33 caspase-1 and NLRP3, but nearly abolished MSU crystal-induced NLRP3 expression and caspase-1 activation.	Uric Acid	106-109	NLR family, pyrin domain containing 3	Mus musculus	126-131
33061523-0	2020	Spinal TLR4/P2X7 Receptor-Dependent NLRP3 Inflammasome Activation Contributes to the Development of Tolerance to Morphine-Induced Antinociception.	Morphine	113-121	NLR family, pyrin domain containing 3	Mus musculus	36-41
33061523-5	2020	Thus far, the mechanism underlying NLRP3 inflammasome activation during morphine-induced tolerance is not yet fully understood.	Morphine	72-80	NLR family, pyrin domain containing 3	Mus musculus	35-40
33061523-6	2020	Therefore, we sought to investigate the mechanisms of NLRP3 inflammasome activation and its role in the development of morphine-induced tolerance.	Morphine	119-127	NLR family, pyrin domain containing 3	Mus musculus	54-59
33061523-10	2020	TLR4 knockout mice and A438079, a P2X7R antagonist, were used to assess the role of TLR4 and P2X7R in chronic morphine-induced NLRP3 inflammasome activation.	Morphine	110-118	NLR family, pyrin domain containing 3	Mus musculus	127-132
33061523-12	2020	Results: Repeated morphine treatment increased the expression of NLRP3.	Morphine	18-26	NLR family, pyrin domain containing 3	Mus musculus	65-70
33061523-13	2020	Knockout of NLRP3 attenuated morphine-induced tolerance and suppressed morphine-induced activation of microglia.	Morphine	29-37	NLR family, pyrin domain containing 3	Mus musculus	12-17
33061523-13	2020	Knockout of NLRP3 attenuated morphine-induced tolerance and suppressed morphine-induced activation of microglia.	Morphine	71-79	NLR family, pyrin domain containing 3	Mus musculus	12-17
33061523-14	2020	Knockout of TLR4 alleviated morphine tolerance and chronic morphine-induced upregulation of spinal NLRP3.	Morphine	59-67	NLR family, pyrin domain containing 3	Mus musculus	99-104
33061523-15	2020	Inhibition of spinal P2X7R with A438079 not only prevented the development of morphine-induced tolerance but also inhibited repeated morphine treatment-induced upregulation of spinal NLRP3.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	32-39	NLR family, pyrin domain containing 3	Mus musculus	183-188
33061523-15	2020	Inhibition of spinal P2X7R with A438079 not only prevented the development of morphine-induced tolerance but also inhibited repeated morphine treatment-induced upregulation of spinal NLRP3.	Morphine	133-141	NLR family, pyrin domain containing 3	Mus musculus	183-188
33061523-17	2020	Conclusion: This study demonstrates that the NLRP3 inflammasome in microglia plays a crucial role in morphine tolerance and that both TLR4- and P2X7R-dependent pathways are required for NLRP3 inflammasome activation over the course of the development of morphine-induced tolerance.	Morphine	101-109	NLR family, pyrin domain containing 3	Mus musculus	45-50
32950971-8	2020	Our results suggest that GPA inhibits NLRP3 inflammasome activation through increasing AMPK phosphorylation to suppress ROS, and can be applied in the prevention of colitis through targeting NLRP3.	Reactive Oxygen Species	120-123	NLR family, pyrin domain containing 3	Mus musculus	38-43
32808642-8	2020	GSPE treatment also reduced NLR family pyrin domain-containing 3 (NLRP3) inflammasome mRNA levels of colon tissue.	gspe	0-4	NLR family, pyrin domain containing 3	Mus musculus	28-64
32808642-8	2020	GSPE treatment also reduced NLR family pyrin domain-containing 3 (NLRP3) inflammasome mRNA levels of colon tissue.	gspe	0-4	NLR family, pyrin domain containing 3	Mus musculus	66-71
32958021-5	2020	Therefore, we tested if BHB inhibition of the NLRP3 inflammasome reduces overall AD pathology in the 5XFAD mouse model of AD.	3-Hydroxybutyric Acid	24-27	NLR family, pyrin domain containing 3	Mus musculus	46-51
32958021-8	2020	Taken together, our findings demonstrate that BHB reduces AD pathology by inhibiting NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	46-49	NLR family, pyrin domain containing 3	Mus musculus	85-90
32943500-3	2020	Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3)- and pyrin-mediated inflammasome assembly, caspase activation, and IL-1beta conversion occur at the microtubule-organizing center (MTOC).	Leucine	46-53	NLR family, pyrin domain containing 3	Mus musculus	106-111
32710952-0	2020	Monotropein alleviates secondary liver injury in chronic colitis by regulating TLR4/NF-kappaB signaling and NLRP3 inflammasome.	monotropein	0-11	NLR family, pyrin domain containing 3	Mus musculus	108-113
33014275-4	2020	R-BHB activates anti-inflammatory GPR109A signaling and inhibits the NLRP3 inflammasome and histone deacetylases, while a ketogenic diet has been shown to protect mice from influenza virus infection through a protective gammadelta T cell response and by increasing electron transport chain gene expression to restore energy metabolism.	r-bhb	0-5	NLR family, pyrin domain containing 3	Mus musculus	69-74
32917982-6	2021	Our results demonstrate that vitamins K3 and K4 exert their anti-inflammatory effects by inhibiting NLRP3 inflammasome activation and indicate that vitamin K supplementation may be a treatment option for NLRP3-associated inflammatory diseases.	vitamins k3 and k4	29-47	NLR family, pyrin domain containing 3	Mus musculus	100-105
32917982-6	2021	Our results demonstrate that vitamins K3 and K4 exert their anti-inflammatory effects by inhibiting NLRP3 inflammasome activation and indicate that vitamin K supplementation may be a treatment option for NLRP3-associated inflammatory diseases.	vitamins k3 and k4	29-47	NLR family, pyrin domain containing 3	Mus musculus	204-209
32917982-6	2021	Our results demonstrate that vitamins K3 and K4 exert their anti-inflammatory effects by inhibiting NLRP3 inflammasome activation and indicate that vitamin K supplementation may be a treatment option for NLRP3-associated inflammatory diseases.	Vitamin K	148-157	NLR family, pyrin domain containing 3	Mus musculus	204-209
32891167-7	2020	The pretreatment of ROS inhibitor N-acetyl-L-cysteine (NAC) significantly attenuated N. caninum-induced ROS production, LDH release, IL-1beta secretion and NLRP3 expression, whereas N. caninum proliferation was notably increased.	Reactive Oxygen Species	20-23	NLR family, pyrin domain containing 3	Mus musculus	156-161
32894139-11	2020	CONCLUSIONS: In conclusion, we unravel a critical role of the NLRP3 inflammasome in Cg-induced pro-inflammatory cytokines production and colitis, which is an important discovery on the pro-inflammatory properties of this sulfated polysaccharide for pre-clinical studies.	Carrageenan	84-86	NLR family, pyrin domain containing 3	Mus musculus	62-67
32894139-11	2020	CONCLUSIONS: In conclusion, we unravel a critical role of the NLRP3 inflammasome in Cg-induced pro-inflammatory cytokines production and colitis, which is an important discovery on the pro-inflammatory properties of this sulfated polysaccharide for pre-clinical studies.	Polysaccharides	230-244	NLR family, pyrin domain containing 3	Mus musculus	62-67
32891167-7	2020	The pretreatment of ROS inhibitor N-acetyl-L-cysteine (NAC) significantly attenuated N. caninum-induced ROS production, LDH release, IL-1beta secretion and NLRP3 expression, whereas N. caninum proliferation was notably increased.	Acetylcysteine	34-53	NLR family, pyrin domain containing 3	Mus musculus	156-161
32891159-12	2020	In vitro, ROS upregulated neuronal pyroptosis and activated the NLRP3 inflammasome pathway, both of which were reversed by addition of a ROS scavenger.	Reactive Oxygen Species	10-13	NLR family, pyrin domain containing 3	Mus musculus	64-69
32891159-12	2020	In vitro, ROS upregulated neuronal pyroptosis and activated the NLRP3 inflammasome pathway, both of which were reversed by addition of a ROS scavenger.	Reactive Oxygen Species	137-140	NLR family, pyrin domain containing 3	Mus musculus	64-69
32891167-7	2020	The pretreatment of ROS inhibitor N-acetyl-L-cysteine (NAC) significantly attenuated N. caninum-induced ROS production, LDH release, IL-1beta secretion and NLRP3 expression, whereas N. caninum proliferation was notably increased.	Acetylcysteine	55-58	NLR family, pyrin domain containing 3	Mus musculus	156-161
32891159-13	2020	Our results suggested that microglial Hv1 regulated neuronal apoptosis and NLRP3-induced neuronal pyroptosis after SCI by mediating ROS production.	Reactive Oxygen Species	132-135	NLR family, pyrin domain containing 3	Mus musculus	75-80
32891167-8	2020	In contrary, the ROS inducer pyrogallol (PG) significantly enhanced ROS production and NLRP3 inflammasome activity and decreased the parasite burden in N. caninum-infected peritoneal macrophages.	Reactive Oxygen Species	17-20	NLR family, pyrin domain containing 3	Mus musculus	87-92
32891167-0	2020	ROS-mediated NLRP3 inflammasome activation participates in the response against Neospora caninum infection.	Reactive Oxygen Species	0-3	NLR family, pyrin domain containing 3	Mus musculus	13-18
32891167-8	2020	In contrary, the ROS inducer pyrogallol (PG) significantly enhanced ROS production and NLRP3 inflammasome activity and decreased the parasite burden in N. caninum-infected peritoneal macrophages.	Pyrogallol	29-39	NLR family, pyrin domain containing 3	Mus musculus	87-92
32891167-8	2020	In contrary, the ROS inducer pyrogallol (PG) significantly enhanced ROS production and NLRP3 inflammasome activity and decreased the parasite burden in N. caninum-infected peritoneal macrophages.	Pyrogallol	41-43	NLR family, pyrin domain containing 3	Mus musculus	87-92
32891167-9	2020	NADPH-dependent ROS-mediated NLRP3 inflammasome activation induced by N. caninum can also be confirmed by using the NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI).	NADP	0-5	NLR family, pyrin domain containing 3	Mus musculus	29-34
32891167-9	2020	NADPH-dependent ROS-mediated NLRP3 inflammasome activation induced by N. caninum can also be confirmed by using the NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI).	Reactive Oxygen Species	16-19	NLR family, pyrin domain containing 3	Mus musculus	29-34
32891167-9	2020	NADPH-dependent ROS-mediated NLRP3 inflammasome activation induced by N. caninum can also be confirmed by using the NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI).	diphenyleneiodonium	140-168	NLR family, pyrin domain containing 3	Mus musculus	29-34
32891167-9	2020	NADPH-dependent ROS-mediated NLRP3 inflammasome activation induced by N. caninum can also be confirmed by using the NADPH oxidase inhibitor diphenyleneiodonium chloride (DPI).	diphenyleneiodonium	170-173	NLR family, pyrin domain containing 3	Mus musculus	29-34
32891167-11	2020	In vivo, IL-18 releases in serum and parasite burdens in peritoneal exudate cells were significantly increased in PG-treated WT mice after infection with N. caninum; however, IL-18 productions and parasite burdens were not changed in PG-treated Nlrp3-/- mice.	Pyrogallol	114-116	NLR family, pyrin domain containing 3	Mus musculus	245-250
32891167-13	2020	CONCLUSIONS: Neospora caninum-induced NADPH-dependent ROS generation plays an important role in NLRP3 inflammasome activation and controlling parasites.	NADP	38-43	NLR family, pyrin domain containing 3	Mus musculus	96-101
32891167-13	2020	CONCLUSIONS: Neospora caninum-induced NADPH-dependent ROS generation plays an important role in NLRP3 inflammasome activation and controlling parasites.	Reactive Oxygen Species	54-57	NLR family, pyrin domain containing 3	Mus musculus	96-101
32891167-14	2020	The ROS inducer PG can control N. caninum infection mainly by promoting NLRP3 inflammasome activation.	Reactive Oxygen Species	4-7	NLR family, pyrin domain containing 3	Mus musculus	72-77
32891167-14	2020	The ROS inducer PG can control N. caninum infection mainly by promoting NLRP3 inflammasome activation.	Pyrogallol	16-18	NLR family, pyrin domain containing 3	Mus musculus	72-77
32891167-15	2020	ROS-mediated NLRP3 inflammasome axis can be a potential therapeutic target for neosporosis.	Reactive Oxygen Species	0-3	NLR family, pyrin domain containing 3	Mus musculus	13-18
32319265-0	2020	Repurposing Auranofin, an Anti-Rheumatic Gold Compound, to Treat Acne Vulgaris by Targeting the NLRP3 Inflammasome.	Auranofin	12-21	NLR family, pyrin domain containing 3	Mus musculus	96-101
32884023-8	2020	Mechanistically, hADSC-Evs treatment suppressed the DS induced rises in NLRP3 inflammasome formation, caspase-1 activation and IL-1beta maturation.	hadsc-evs	17-26	NLR family, pyrin domain containing 3	Mus musculus	72-77
32884023-8	2020	Mechanistically, hADSC-Evs treatment suppressed the DS induced rises in NLRP3 inflammasome formation, caspase-1 activation and IL-1beta maturation.	ds	19-21	NLR family, pyrin domain containing 3	Mus musculus	72-77
32884023-9	2020	In conclusion, hADSC-Evs eye drops effectively suppress NLRP3 inflammatory response and alleviate ocular surface damage in dry eye disease.	hadsc-evs	15-24	NLR family, pyrin domain containing 3	Mus musculus	56-61
32559625-11	2020	OEA antiinflammatory effects were mediated by the selective targeting of the TLR4 axis causing a downstream inhibition of nuclear factor kappa B (NF-kappaB)- MyD88-dependent and NLRP3 inflammation pathways.	N-oleoylethanolamine	0-3	NLR family, pyrin domain containing 3	Mus musculus	178-183
32983127-7	2020	Mitochondrial ROS and mitochondrial DNA activate NLRP3 inflammasome and the DNA sensors cGAS and STING accelerating cell death pathways including caspases with inflammation enhancing alveolar septa destruction, remodeling, and fibrosis.	Reactive Oxygen Species	14-17	NLR family, pyrin domain containing 3	Mus musculus	49-54
33042624-2	2020	Although it is recognized that NLRP3 (nucleotide-binding domain, leucine-rich repeat-containing family, pyrin domain-containing 3) inflammasome is involved in pyroptosis activation, the mechanism by which head and neck squamous cell carcinoma (HNSCC) inhibits pyroptotic cell death remains undefined.	Leucine	65-72	NLR family, pyrin domain containing 3	Mus musculus	31-36
33042624-3	2020	This study aims to delineate the role of calcium regulator CD38 in NLRP3 inflammasome-dependent pyroptosis in HNSCC.	Calcium	41-48	NLR family, pyrin domain containing 3	Mus musculus	67-72
33042624-16	2020	ChIP assay indicated that calcium-sensitive transcription factor NFAT1 was possibly involved in the transcriptional upregulation of NLRP3 observed in CD38-overexpressing HNSCC.	Calcium	26-33	NLR family, pyrin domain containing 3	Mus musculus	132-137
32319265-4	2020	In this study, we investigated whether auranofin, an anti-rheumatoid arthritis agent, inhibited NLRP3 inflammasome activation, thereby effectively treating acne vulgaris.	Auranofin	39-48	NLR family, pyrin domain containing 3	Mus musculus	96-101
32319265-5	2020	Auranofin suppressed NLRP3 inflammasome activation induced by Propionibacterium acnes, reducing the production of IL-1beta in primary mouse macrophages and human sebocytes.	Auranofin	0-9	NLR family, pyrin domain containing 3	Mus musculus	21-26
32738997-0	2020	Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome.	parthenolide	39-51	NLR family, pyrin domain containing 3	Mus musculus	117-122
32319265-8	2020	Topical application of auranofin led to the downregulation of the NLRP3 inflammasome activated by P. acnes in mouse ear skin.	Auranofin	23-32	NLR family, pyrin domain containing 3	Mus musculus	66-71
32738997-1	2020	Parthenolide (PTL) can target NLRP3 inflammasome to treat inflammation and its related disease, but its cytotoxicity limits further development as an anti-inflammatory drug.	parthenolide	0-12	NLR family, pyrin domain containing 3	Mus musculus	30-35
32319265-9	2020	These results show that auranofin inhibits the NLRP3 inflammasome, the activation of which is associated with acne symptoms.	Auranofin	24-33	NLR family, pyrin domain containing 3	Mus musculus	47-52
32738997-1	2020	Parthenolide (PTL) can target NLRP3 inflammasome to treat inflammation and its related disease, but its cytotoxicity limits further development as an anti-inflammatory drug.	parthenolide	14-17	NLR family, pyrin domain containing 3	Mus musculus	30-35
32319265-10	2020	The results further suggest that topical application of auranofin could be a new therapeutic strategy for treating acne vulgaris by targeting the NLRP3 inflammasome.	Auranofin	56-65	NLR family, pyrin domain containing 3	Mus musculus	146-151
32656909-0	2020	Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.	wedelolactone	0-13	NLR family, pyrin domain containing 3	Mus musculus	53-58
32656909-0	2020	Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.	Serine	26-29	NLR family, pyrin domain containing 3	Mus musculus	53-58
32656909-0	2020	Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.	Threonine	30-33	NLR family, pyrin domain containing 3	Mus musculus	53-58
32656909-7	2020	RESULTS: We found that wedelolactone broadly inhibited NLRP3 inflammasome activation and pyroptosis and IL-1beta secretion.	wedelolactone	23-36	NLR family, pyrin domain containing 3	Mus musculus	55-60
32656909-9	2020	The inhibitory effects of wedelolactone were abrogated by PKA inhibitor H89, which also attenuated wedelolactone-enhanced Ser/Thr phosphorylation of NLRP3 at PKA-specific sites.	wedelolactone	26-39	NLR family, pyrin domain containing 3	Mus musculus	149-154
32656909-9	2020	The inhibitory effects of wedelolactone were abrogated by PKA inhibitor H89, which also attenuated wedelolactone-enhanced Ser/Thr phosphorylation of NLRP3 at PKA-specific sites.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	72-75	NLR family, pyrin domain containing 3	Mus musculus	149-154
32656909-9	2020	The inhibitory effects of wedelolactone were abrogated by PKA inhibitor H89, which also attenuated wedelolactone-enhanced Ser/Thr phosphorylation of NLRP3 at PKA-specific sites.	wedelolactone	99-112	NLR family, pyrin domain containing 3	Mus musculus	149-154
32402876-10	2020	PBP, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger.	pentabromophenol	0-3	NLR family, pyrin domain containing 3	Mus musculus	76-81
32656909-9	2020	The inhibitory effects of wedelolactone were abrogated by PKA inhibitor H89, which also attenuated wedelolactone-enhanced Ser/Thr phosphorylation of NLRP3 at PKA-specific sites.	Serine	122-125	NLR family, pyrin domain containing 3	Mus musculus	149-154
32656909-9	2020	The inhibitory effects of wedelolactone were abrogated by PKA inhibitor H89, which also attenuated wedelolactone-enhanced Ser/Thr phosphorylation of NLRP3 at PKA-specific sites.	Threonine	126-129	NLR family, pyrin domain containing 3	Mus musculus	149-154
32656909-11	2020	CONCLUSION: Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.	wedelolactone	38-51	NLR family, pyrin domain containing 3	Mus musculus	92-97
32656909-11	2020	CONCLUSION: Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.	Serine	65-68	NLR family, pyrin domain containing 3	Mus musculus	92-97
32656909-11	2020	CONCLUSION: Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.	Threonine	69-72	NLR family, pyrin domain containing 3	Mus musculus	92-97
32727891-5	2020	Intestinal I/R injury caused acute lung injury (ALI) characterized by inflammation, reactive oxygen species generation, and vascular permeability, which was markedly improved by NLRP3 deficiency.	Oxygen	93-99	NLR family, pyrin domain containing 3	Mus musculus	178-183
32679538-8	2020	Moreover, pIL-35 pretreatment significantly decreased the levels of cardiac proinflammatory cytokines including TNF-alpha, IL-6, and IL-1beta, and the NLRP3 inflammasome.	pil-35	10-16	NLR family, pyrin domain containing 3	Mus musculus	151-156
32593156-0	2020	Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.	phthalide	0-9	NLR family, pyrin domain containing 3	Mus musculus	135-140
32563803-8	2020	Our study demonstrated that the protective therapeutic action of SIFs on DSS-induced colitis depended on inhibition of ERalpha and subsequent NLRP3 inflammasome activation, and SIFs are promising therapeutic agents for the treatment of colitis.	dss	73-76	NLR family, pyrin domain containing 3	Mus musculus	142-147
32701014-7	2020	Moreover, Psb pretreatment effectively suppressed inflammation by decreasing NLRP3 inflammasome, MAPK, and NF-kappaB pathway activations.	pterostilbene	10-13	NLR family, pyrin domain containing 3	Mus musculus	77-82
32701014-9	2020	This was the first study to demonstrate that Psb protects against L/D-induced ALF by inactivating MAPK, NF-kappab, and NLRP3 inflammasome and upregulating the Nrf2 signaling pathway, indicating a potential therapeutic application for ALF treatment.	pterostilbene	45-48	NLR family, pyrin domain containing 3	Mus musculus	119-124
32563803-0	2020	Soy isoflavones ameliorate experimental colitis by targeting ERalpha/NLRP3 inflammasome pathways.	Isoflavones	0-15	NLR family, pyrin domain containing 3	Mus musculus	69-74
32701014-0	2020	Pterostilbene Protects Against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF-kappaB, MAPK, and NLRP3 Inflammasome Activation.	pterostilbene	0-13	NLR family, pyrin domain containing 3	Mus musculus	163-168
32701014-0	2020	Pterostilbene Protects Against Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF-kappaB, MAPK, and NLRP3 Inflammasome Activation.	Galactosamine	50-65	NLR family, pyrin domain containing 3	Mus musculus	163-168
32908485-13	2020	Meanwhile, compared to the stroke and stroke+PBS group, Ki20227 administration downregulated the expression of NLRP3, active caspase 1, and NF-kappaB protein in the ischemia penumbra of Ki20227 treatment group mice.	N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea	56-63	NLR family, pyrin domain containing 3	Mus musculus	111-116
32504759-7	2020	Moreover, PQQ inhibited the NLRP3 inflammatory pathway, as indicated by the reduced expression of NLRP3, ASC, and Caspase-1.	PQQ Cofactor	10-13	NLR family, pyrin domain containing 3	Mus musculus	28-33
32504759-7	2020	Moreover, PQQ inhibited the NLRP3 inflammatory pathway, as indicated by the reduced expression of NLRP3, ASC, and Caspase-1.	PQQ Cofactor	10-13	NLR family, pyrin domain containing 3	Mus musculus	98-103
32504759-8	2020	SIGNIFICANCE: Our results suggest that PQQ protects against CTX-induced nephrotoxicity, probably by activating the Nrf2-mediated antioxidant pathway and inhibiting the NLRP3 inflammatory pathway.	PQQ Cofactor	39-42	NLR family, pyrin domain containing 3	Mus musculus	168-173
32705202-8	2020	Asiaticoside administration also downregulated the levels of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha in the hippocampus, and reduced the phosphorylation of nuclear factor (NF)-kappaBp65 and the expression of nod-like receptor protein 3 (NLRP3), thus decreasing the expression of mature caspase-1.	asiaticoside	0-12	NLR family, pyrin domain containing 3	Mus musculus	229-256
32705202-8	2020	Asiaticoside administration also downregulated the levels of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha in the hippocampus, and reduced the phosphorylation of nuclear factor (NF)-kappaBp65 and the expression of nod-like receptor protein 3 (NLRP3), thus decreasing the expression of mature caspase-1.	asiaticoside	0-12	NLR family, pyrin domain containing 3	Mus musculus	258-263
32705202-10	2020	Therefore, asiaticoside may activate the cAMP/PKA signaling pathway to inhibit NF-kappaB- and NLRP3-related inflammation.	asiaticoside	11-23	NLR family, pyrin domain containing 3	Mus musculus	94-99
32556930-6	2020	In addition, NaB upregulated the expression of pro-inflammatory cytokines (IL-6, 3.52-fold, P < 0.05; IL-18, 1.72-fold, P < 0.001) and NLRP3 (3.11-fold, P < 0.001) in the colon of PD mice.	nab	13-16	NLR family, pyrin domain containing 3	Mus musculus	135-140
32683554-8	2020	Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage-NLRP3 inflammasome activation is a pathway underlying the brain-heart interaction after diabetic stroke.	CY5.5 cyanine dye	46-51	NLR family, pyrin domain containing 3	Mus musculus	17-22
32683554-8	2020	Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage-NLRP3 inflammasome activation is a pathway underlying the brain-heart interaction after diabetic stroke.	CY5.5 cyanine dye	46-51	NLR family, pyrin domain containing 3	Mus musculus	123-128
32808001-6	2020	Further investigations reveal that FNs could effectively inhibit the activation of NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome, and thus prevent the secretion of mature IL-1beta and neutrophil influx, deriving from the superior ROS scavenging capability.	ros	253-256	NLR family, pyrin domain containing 3	Mus musculus	83-88
32504759-0	2020	Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway.	PQQ Cofactor	21-45	NLR family, pyrin domain containing 3	Mus musculus	144-149
32504759-0	2020	Ameliorate effect of pyrroloquinoline quinone against cyclophosphamide-induced nephrotoxicity by activating the Nrf2 pathway and inhibiting the NLRP3 pathway.	Cyclophosphamide	54-70	NLR family, pyrin domain containing 3	Mus musculus	144-149
32266697-0	2020	Sleeve Gastroplasty Combined with the NLRP3 Inflammasome Inhibitor CY-09 Reduces Body Weight, Improves Insulin Resistance and Alleviates Hepatic Steatosis in Mouse Model.	CY5.5 cyanine dye	67-72	NLR family, pyrin domain containing 3	Mus musculus	38-43
32266697-2	2020	A small molecule named CY-09 is the selective inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome.	CY5.5 cyanine dye	23-28	NLR family, pyrin domain containing 3	Mus musculus	63-114
32266697-2	2020	A small molecule named CY-09 is the selective inhibitor of the NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome.	CY5.5 cyanine dye	23-28	NLR family, pyrin domain containing 3	Mus musculus	116-121
32585162-10	2020	Additionally, cholecalciferol treatment per se reduced the immunocontent of NLRP3 inflammasome-related proteins ASC, caspase-1, and TXNIP in the hippocampus of mice.	Cholecalciferol	14-29	NLR family, pyrin domain containing 3	Mus musculus	76-81
32706026-0	2020	LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression.	gm14205	7-14	NLR family, pyrin domain containing 3	Mus musculus	34-39
32706026-7	2020	Furthermore, we focused on one of the five lncRNAs, Gm14205, and found that it targeted OXTR which inhibited astrocytic NLRP3 inflammasome activation in hippocampal primary astrocytes.	gm14205	52-59	NLR family, pyrin domain containing 3	Mus musculus	120-125
32908485-13	2020	Meanwhile, compared to the stroke and stroke+PBS group, Ki20227 administration downregulated the expression of NLRP3, active caspase 1, and NF-kappaB protein in the ischemia penumbra of Ki20227 treatment group mice.	N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea	186-193	NLR family, pyrin domain containing 3	Mus musculus	111-116
32908485-14	2020	In short, the CSF1R inhibitor, Ki20227, played vital neuroprotective roles in ischemia cerebral stroke mice, and the mechanisms may be via inhibiting microglia M1 polarization and NLRP3 inflammasome pathway activation.	N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea	31-38	NLR family, pyrin domain containing 3	Mus musculus	180-185
32854770-9	2020	These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response.	th2	132-135	NLR family, pyrin domain containing 3	Mus musculus	35-40
32854770-9	2020	These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response.	treg	140-144	NLR family, pyrin domain containing 3	Mus musculus	76-81
32854770-9	2020	These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response.	th2	132-135	NLR family, pyrin domain containing 3	Mus musculus	76-81
32854770-9	2020	These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response.	treg	140-144	NLR family, pyrin domain containing 3	Mus musculus	35-40
32908628-0	2020	Resveratrol Inhibits Ischemia-Induced Myocardial Senescence Signals and NLRP3 Inflammasome Activation.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	72-77
32908628-13	2020	Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation.	Resveratrol	27-30	NLR family, pyrin domain containing 3	Mus musculus	199-204
32703418-0	2020	Trans-unsaturated fatty acid activates NLRP3 inflammasome in macrophages and exacerbates intestinal inflammation in mice.	trans-unsaturated fatty acid	0-28	NLR family, pyrin domain containing 3	Mus musculus	39-44
32835606-0	2021	1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.	1-deoxysphingolipid	0-20	NLR family, pyrin domain containing 3	Mus musculus	79-84
32829380-9	2020	Our data demonstrate that ELA prevents DOCA/salt-induced hypertension by inhibiting NADPH oxidase/ROS/NLRP3 pathway in the kidney, which is APJ independent.	Desoxycorticosterone Acetate	39-43	NLR family, pyrin domain containing 3	Mus musculus	102-107
32829380-9	2020	Our data demonstrate that ELA prevents DOCA/salt-induced hypertension by inhibiting NADPH oxidase/ROS/NLRP3 pathway in the kidney, which is APJ independent.	Reactive Oxygen Species	98-101	NLR family, pyrin domain containing 3	Mus musculus	102-107
32526245-0	2020	Down-regulation of DJ-1 augments neuroinflammation via Nrf2/Trx1/NLRP3 axis in MPTP-induced Parkinson"s disease mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	79-83	NLR family, pyrin domain containing 3	Mus musculus	65-70
32703418-3	2020	We demonstrate here that elaidate, a trans-isomer of oleate, enhances interleukin (IL)-1beta production through the activation of NLRP3 inflammasome in mouse bone marrow-derived macrophages (BMDMs).	elaidic acid	25-33	NLR family, pyrin domain containing 3	Mus musculus	130-135
32778044-0	2021	Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole.	Pentylenetetrazole	91-109	NLR family, pyrin domain containing 3	Mus musculus	34-39
32407845-8	2020	Finally, we found that CD38 inhibitors, nicotinamide and telmisartan significantly improved the endothelium-independent contraction and vascular remodeling, which was also associated with the inhibition of NLRP3 inflammasome in the aorta media in the diabetic mice.	Niacinamide	40-52	NLR family, pyrin domain containing 3	Mus musculus	206-211
32407845-8	2020	Finally, we found that CD38 inhibitors, nicotinamide and telmisartan significantly improved the endothelium-independent contraction and vascular remodeling, which was also associated with the inhibition of NLRP3 inflammasome in the aorta media in the diabetic mice.	Telmisartan	57-68	NLR family, pyrin domain containing 3	Mus musculus	206-211
32903542-8	2020	Finally, CypA inhibitor TMN355 attenuated liver steatosis and injury and inhibited NF-kappaB/NLRP3 signaling pathway.	TMN 355	24-30	NLR family, pyrin domain containing 3	Mus musculus	93-98
32850832-0	2020	Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis.	Isoproterenol	80-93	NLR family, pyrin domain containing 3	Mus musculus	0-57
32850832-0	2020	Nucleotide-Binding Oligomerization Domain-Like Receptor 3 Deficiency Attenuated Isoproterenol-Induced Cardiac Fibrosis via Reactive Oxygen Species/High Mobility Group Box 1 Protein Axis.	Reactive Oxygen Species	123-146	NLR family, pyrin domain containing 3	Mus musculus	0-57
32850832-3	2020	The study aims to investigate the role of NLRP3 on cardiac fibrosis induced by isoproterenol (ISO).	Isoproterenol	79-92	NLR family, pyrin domain containing 3	Mus musculus	42-47
32850832-3	2020	The study aims to investigate the role of NLRP3 on cardiac fibrosis induced by isoproterenol (ISO).	Isoproterenol	94-97	NLR family, pyrin domain containing 3	Mus musculus	42-47
32850832-4	2020	In vivo, NLRP3 knockout and wild-type mice were subcutaneously injected with ISO to induce the cardiac fibrosis model.	Isoproterenol	77-80	NLR family, pyrin domain containing 3	Mus musculus	9-14
32850832-5	2020	The results showed that NLRP3 deficiency alleviated the cardiac fibrosis and inflammation induced by ISO.	Isoproterenol	101-104	NLR family, pyrin domain containing 3	Mus musculus	24-29
32850832-8	2020	We found that NLRP3 could regulate high-mobility group box 1 protein (HMGB1) secretion via reactive oxygen species production in NRVMs and the HMGB1 secreted by NRVMs promoted the activation and proliferation of cardiac fibroblasts.	Reactive Oxygen Species	91-114	NLR family, pyrin domain containing 3	Mus musculus	14-19
32778044-1	2021	BACKGROUND: While our previous research has demonstrated that the NLRP3 inflammasome is involved in epilepsy progression, the effects of the specific NLRP3 inhibitor CY-09 remain poorly understood.	CY5.5 cyanine dye	166-171	NLR family, pyrin domain containing 3	Mus musculus	150-155
32850832-9	2020	Thus, we concluded that the NLRP3/reactive oxygen species/HMGB1 pathway could be the underlying mechanism of ISO-induced cardiac fibrosis.	Isoproterenol	109-112	NLR family, pyrin domain containing 3	Mus musculus	28-33
32778044-7	2021	CONCLUSION: These findings indicate that CY-09 may represent an important treatment agent for epilepsy and other NLRP3 inflammasome-associated diseases.	CY5.5 cyanine dye	41-46	NLR family, pyrin domain containing 3	Mus musculus	113-118
32778128-0	2020	Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells.	Silicon Dioxide	12-18	NLR family, pyrin domain containing 3	Mus musculus	41-46
32778128-8	2020	FCCP, a mitochondrial uncoupler, as well as overexpressed NLRP3 mimicked the silica-induced depolarization and the DNA damage response.	Silicon Dioxide	77-83	NLR family, pyrin domain containing 3	Mus musculus	58-63
33505579-2	2020	We investigated whether fucoidan, a marine sulfated polysaccharide derived from brown seaweeds, could reduce NLRP3 inflammasome activation by enhancing sequestosome 1 (p62/SQSTM1)-dependent selective autophagy to alleviate atherosclerosis in high-fat-fed ApoE-/- mice with partial carotid ligation and differentiated THP-1 cells incubated with oxidized low-density lipoprotein (oxLDL).	fucoidan	24-32	NLR family, pyrin domain containing 3	Mus musculus	109-114
32784362-8	2020	Studies also showed that SsnB was effective in suppressing TLR4-induced nod-like receptor protein 3 (NLRP3) inflammasome activation, a prominent inflammatory disease pathway.	sparstolonin B	25-29	NLR family, pyrin domain containing 3	Mus musculus	72-99
32784362-8	2020	Studies also showed that SsnB was effective in suppressing TLR4-induced nod-like receptor protein 3 (NLRP3) inflammasome activation, a prominent inflammatory disease pathway.	sparstolonin B	25-29	NLR family, pyrin domain containing 3	Mus musculus	101-106
32784362-10	2020	Inactivation of SsnB by treating the parent molecule by acetate reversed the deactivation of NLRP3 inflammasome and astrocytes in vitro, suggesting that SsnB molecular motifs may be responsible for its anti-inflammatory activity.	sparstolonin B	16-20	NLR family, pyrin domain containing 3	Mus musculus	93-98
32784362-10	2020	Inactivation of SsnB by treating the parent molecule by acetate reversed the deactivation of NLRP3 inflammasome and astrocytes in vitro, suggesting that SsnB molecular motifs may be responsible for its anti-inflammatory activity.	Acetates	56-63	NLR family, pyrin domain containing 3	Mus musculus	93-98
32784362-10	2020	Inactivation of SsnB by treating the parent molecule by acetate reversed the deactivation of NLRP3 inflammasome and astrocytes in vitro, suggesting that SsnB molecular motifs may be responsible for its anti-inflammatory activity.	sparstolonin B	153-157	NLR family, pyrin domain containing 3	Mus musculus	93-98
32761175-0	2020	Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson"s Disease.	baicalein	0-9	NLR family, pyrin domain containing 3	Mus musculus	53-58
32761175-0	2020	Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson"s Disease.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	86-90	NLR family, pyrin domain containing 3	Mus musculus	53-58
32761175-8	2020	Baicalein also inhibited NLRP3 and caspase-1 activation and suppressed gasdermin D (GSDMD)-dependent pyroptosis.	baicalein	0-9	NLR family, pyrin domain containing 3	Mus musculus	25-30
32761175-10	2020	CONCLUSIONS: These findings suggest that baicalein can reverse MPTP-induced neuroinflammation in mice by suppressing NLRP3/caspase-1/GSDMD pathway.	baicalein	41-50	NLR family, pyrin domain containing 3	Mus musculus	117-122
32761175-10	2020	CONCLUSIONS: These findings suggest that baicalein can reverse MPTP-induced neuroinflammation in mice by suppressing NLRP3/caspase-1/GSDMD pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	63-67	NLR family, pyrin domain containing 3	Mus musculus	117-122
32454054-4	2020	We found that depressive-like behavior in streptozotocin (STZ)-induced diabetic mice was associated with hippocampal NLRP3 inflammasome activation.	Streptozocin	42-56	NLR family, pyrin domain containing 3	Mus musculus	117-122
32454054-4	2020	We found that depressive-like behavior in streptozotocin (STZ)-induced diabetic mice was associated with hippocampal NLRP3 inflammasome activation.	Streptozocin	58-61	NLR family, pyrin domain containing 3	Mus musculus	117-122
32454054-5	2020	Hyperglycemia increased reactive oxygen species (ROS) production, thus leading to NLRP3 inflammasome activation in hippocampal neurons.	Reactive Oxygen Species	24-47	NLR family, pyrin domain containing 3	Mus musculus	82-87
32454054-5	2020	Hyperglycemia increased reactive oxygen species (ROS) production, thus leading to NLRP3 inflammasome activation in hippocampal neurons.	Reactive Oxygen Species	49-52	NLR family, pyrin domain containing 3	Mus musculus	82-87
32765674-0	2020	miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression.	mir-223-3p	0-10	NLR family, pyrin domain containing 3	Mus musculus	108-113
32454054-6	2020	It was found that STZ treatment induced apoptotic and pyroptotic cell death in the hippocampus as evidenced by increases of cleaved caspase 3 positive hippocampal neurons, TUNEL-positive cells, protein levels of p53, Bax, Puma, and the cleaved GSDMD N-terminal fragment, all of which were decreased in NLRP3 deficient mice.	Streptozocin	18-21	NLR family, pyrin domain containing 3	Mus musculus	302-307
32454054-7	2020	Using murine hippocampal neuronal cell line HT22, we found that high glucose induced apoptotic and pyroptotic cell death in a NLRP3 inflammasome-dependent manner in vitro.	Glucose	69-76	NLR family, pyrin domain containing 3	Mus musculus	126-131
32454054-8	2020	In addition, NLRP3 deficiency alleviated depressive-like behavior in STZ-induced diabetic mice.	Streptozocin	69-72	NLR family, pyrin domain containing 3	Mus musculus	13-18
32454054-9	2020	Our results suggest that hyperglycemia results in apoptosis and pyroptosis of hippocampal neuron cells in a NLRP3-dependent manner, which was associated with the depressive phenotypes evoked by STZ-induced diabetes.	Streptozocin	194-197	NLR family, pyrin domain containing 3	Mus musculus	108-113
32454054-10	2020	The study identifies a novel function of NLRP3 activation in high glucose-induced neuronal cell death, which sheds further light on the pathogenesis and new therapeutic targets of diabetes-associated depression.	Glucose	66-73	NLR family, pyrin domain containing 3	Mus musculus	41-46
32666684-11	2020	The results showed that the elderly recipients had much higher levels of TNF-alpha, IL-6, IL-1beta, and IL-18 post-transplantation, indicating increased NLRP3 activation in lR-stressed livers of elderly recipients.	Lawrencium	173-175	NLR family, pyrin domain containing 3	Mus musculus	153-158
32953791-0	2020	Micheliolide alleviates ankylosing spondylitis (AS) by suppressing the activation of the NLRP3 inflammasome and maintaining the balance of Th1/Th2 via regulating the NF-kappaB signaling pathway.	micheliolide	0-12	NLR family, pyrin domain containing 3	Mus musculus	89-94
32953791-10	2020	After the addition of celastrol, MCL treatment significantly reduced the levels of p-p65, NLRP3, caspase-1, and ASC.	celastrol	22-31	NLR family, pyrin domain containing 3	Mus musculus	90-95
32297666-6	2020	Furthermore, SESN1 suppressed cholesterol crystal-induced NLRP3 inflammasome activation and foam cell formation.	Cholesterol	30-41	NLR family, pyrin domain containing 3	Mus musculus	58-63
32774172-8	2020	Maternal L-Carnitine supplementation significantly reduced NLRP3 level.	Carnitine	9-20	NLR family, pyrin domain containing 3	Mus musculus	59-64
32480011-6	2020	GSDMD positive cells and NLRP3 inflammasome expression were augmented in gingival tissue, which were partly reversed by metformin.	Metformin	120-129	NLR family, pyrin domain containing 3	Mus musculus	25-30
32335797-0	2020	Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK-mTOR Interplay.	dapagliflozin	0-13	NLR family, pyrin domain containing 3	Mus musculus	95-100
32335797-0	2020	Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK-mTOR Interplay.	Ticagrelor	18-28	NLR family, pyrin domain containing 3	Mus musculus	95-100
32335797-1	2020	PURPOSE: Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome.	Ticagrelor	9-19	NLR family, pyrin domain containing 3	Mus musculus	144-149
32335797-1	2020	PURPOSE: Ticagrelor, a P2Y12 receptor antagonist, and dapagliflozin, a sodium-glucose-cotransporter-2 inhibitor, suppress the activation of the NLRP3 inflammasome.	dapagliflozin	54-67	NLR family, pyrin domain containing 3	Mus musculus	144-149
32335797-12	2020	Moreover, only dapagliflozin decreased myocardial BNP and Caspase-1 mRNA levels, and the effects of dapagliflozin on NLRP3 and collagen-3 mRNA levels were significantly greater than those of ticagrelor.	dapagliflozin	100-113	NLR family, pyrin domain containing 3	Mus musculus	117-122
32335797-13	2020	CONCLUSIONS: Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination.	dapagliflozin	18-31	NLR family, pyrin domain containing 3	Mus musculus	124-129
32335797-13	2020	CONCLUSIONS: Both dapagliflozin and ticagrelor attenuated the progression of diabetic cardiomyopathy, the activation of the NLRP3 inflammasome, and fibrosis in BTBR mice with additive effects of the combination.	Ticagrelor	36-46	NLR family, pyrin domain containing 3	Mus musculus	124-129
32196713-7	2020	In ovalbumin-induced asthmatic mice, atractylenolide III treatment also significantly inhibited NLRP3 inflammasome activation and restored the Th1/Th2 balance.	(+)-Atractylenolide	37-52	NLR family, pyrin domain containing 3	Mus musculus	96-101
32167222-0	2020	Glyburide attenuates ozone-induced pulmonary inflammation and injury by blocking the NLRP3 inflammasome.	Glyburide	0-9	NLR family, pyrin domain containing 3	Mus musculus	85-90
32167222-9	2020	In addition, glyburide inhibited the expression of NLRP3, IL-18, and IL-1beta protein in lung tissues, and also suppressed NLRP3 inflammasome activation, including caspase-1 p10, active IL-1beta protein in lung tissues, IL-1beta, and IL-18 in BALF.	Glyburide	13-22	NLR family, pyrin domain containing 3	Mus musculus	51-56
32167222-9	2020	In addition, glyburide inhibited the expression of NLRP3, IL-18, and IL-1beta protein in lung tissues, and also suppressed NLRP3 inflammasome activation, including caspase-1 p10, active IL-1beta protein in lung tissues, IL-1beta, and IL-18 in BALF.	Glyburide	13-22	NLR family, pyrin domain containing 3	Mus musculus	123-128
32167222-10	2020	These results demonstrate that glyburide effectively attenuates ozone-induced pulmonary inflammation and injury via blocking the NLRP3 inflammasome.	Glyburide	31-40	NLR family, pyrin domain containing 3	Mus musculus	129-134
32542792-6	2020	Our studies identify that RIPK3 promotes renal fibrosis via the activation of the NLRP3 inflammasome in a mouse model of folic acid-induced nephropathy.	Folic Acid	121-131	NLR family, pyrin domain containing 3	Mus musculus	82-87
32765674-0	2020	miR-223-3p reduces high glucose and high fat-induced endothelial cell injury in diabetic mice by regulating NLRP3 expression.	Glucose	24-31	NLR family, pyrin domain containing 3	Mus musculus	108-113
32765674-1	2020	Expression levels of miR-223-3p and NLRP3 in high glucose and high fat (HGHF)-induced diabetic mice, and the mechanism on the injury of mouse cardiac microvascular endothelial cells (MCMECs) were investigated.	Glucose	50-57	NLR family, pyrin domain containing 3	Mus musculus	36-41
32765674-6	2020	Flow cytometry was used to observe apoptosis and TargetScan to predict the target relationship between miR-223-3p and NLRP3.	mir-223-3p	103-113	NLR family, pyrin domain containing 3	Mus musculus	118-123
32765674-7	2020	Dual-luciferase reporter gene assay was used to detect the relationship between miR-223-3p and NLRP3.	mir-223-3p	80-90	NLR family, pyrin domain containing 3	Mus musculus	95-100
32765674-12	2020	miR-223-3p reduces the injury of MCMECs and inhibits endothelial cell apoptosis in mice by regulating the expression of NLRP3.	mir-223-3p	0-10	NLR family, pyrin domain containing 3	Mus musculus	120-125
32239396-10	2020	The decline of p-eNOS, endothelium-dependent vasodilation function, and survival rate significantly improved with NLRP3-specific inhibitor MCC950 intervention or NLRP3 knockout in CLP mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	139-145	NLR family, pyrin domain containing 3	Mus musculus	114-119
32521491-0	2020	Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway.	ginsenoside Rk3	0-15	NLR family, pyrin domain containing 3	Mus musculus	101-106
32419528-7	2020	We found that aloin significantly inhibited the activation of NF-kappaB and NLRP3 inflammasome in ALI induced by LPS.	alloin	14-19	NLR family, pyrin domain containing 3	Mus musculus	76-81
32419528-8	2020	Meanwhile, aloin was found to increase the expression of SIRT1 and inhibition of SIRT1 by EX-527 reversed the protective effects of aloin.Conclusions: These results suggest that aloin exerts its protective effects on LPS-induced ALI by activation SIRT1, which subsequently results in the suppression of NF-kappaB and NLRP3 inflammasome.	alloin	132-137	NLR family, pyrin domain containing 3	Mus musculus	317-322
32419528-8	2020	Meanwhile, aloin was found to increase the expression of SIRT1 and inhibition of SIRT1 by EX-527 reversed the protective effects of aloin.Conclusions: These results suggest that aloin exerts its protective effects on LPS-induced ALI by activation SIRT1, which subsequently results in the suppression of NF-kappaB and NLRP3 inflammasome.	alloin	132-137	NLR family, pyrin domain containing 3	Mus musculus	317-322
32435966-10	2020	In the present study, we demonstrate that PNX-14 could attenuate LPS-induced ER stress response and NLRP3 inflammasome activation in mouse cerebral astrocytes.	pnx-14	42-48	NLR family, pyrin domain containing 3	Mus musculus	100-105
32419528-0	2020	Aloin suppresses lipopolysaccharide-induced acute lung injury by inhibiting NLRP3/NF-kappaB via activation of SIRT1 in mice.	alloin	0-5	NLR family, pyrin domain containing 3	Mus musculus	76-81
32531709-0	2020	Betulin alleviates on myocardial inflammation in diabetes mice via regulating Siti1/NLRP3/NF-kappaB pathway.	betulin	0-7	NLR family, pyrin domain containing 3	Mus musculus	84-89
32473572-6	2020	Furthermore, GTD treatment could significantly inhibit inflammation-related signaling pathways activated by LPS/GalN, including the suppression of nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) and nuclear factor-kappa B (NF-kappaB) activation.	gastrodin	13-16	NLR family, pyrin domain containing 3	Mus musculus	204-209
32473572-8	2020	Taken together, our investigation indicated that GTD played an essential role in liver protection by relieving hepatocyte apoptosis and inflammation reaction, which may be closely involved in the inhibition of NLRP3 inflammasome and NF-kappaB activation, regulation of apoptosis-related proteins expression, and the recovery of AMPK/ACC/autophagy.	gastrodin	49-52	NLR family, pyrin domain containing 3	Mus musculus	210-215
32535537-0	2020	Activation of NLRP3 inflammasome in RAW 264.7 cells by polysaccharides extracted from Grateloupia livida (Harv.)	Polysaccharides	55-70	NLR family, pyrin domain containing 3	Mus musculus	14-19
32470468-9	2020	Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H2O2-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 macrophages, which were abrogated by Met treatment.	ros	239-242	NLR family, pyrin domain containing 3	Mus musculus	180-185
32544869-0	2020	Salidroside protects mice against CCl4-induced acute liver injury via down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	119-124
32544869-6	2020	Finally, Sal also down-regulated the expression of cytochrome P4502E1 (CYP2E1), and Nod-like receptor protein 3 (NLRP3) inflammasome activation in the liver of mice by CCl4.	rhodioloside	9-12	NLR family, pyrin domain containing 3	Mus musculus	84-111
32544869-6	2020	Finally, Sal also down-regulated the expression of cytochrome P4502E1 (CYP2E1), and Nod-like receptor protein 3 (NLRP3) inflammasome activation in the liver of mice by CCl4.	rhodioloside	9-12	NLR family, pyrin domain containing 3	Mus musculus	113-118
32544869-7	2020	Our study demonstrates that Sal exerts its hepatoprotective effects on ALI through its antioxidant and anti-inflammatory effects, which might be mediated by down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation.	rhodioloside	28-31	NLR family, pyrin domain containing 3	Mus musculus	206-211
32470468-0	2020	Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	84-89
32470468-0	2020	Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages.	ros	80-83	NLR family, pyrin domain containing 3	Mus musculus	84-89
32470468-11	2020	Collectively, these findings suggest that Met protects against ischaemic myocardial injury through alleviating autophagy-ROS-NLRP3 axis-mediated inflammatory response in macrophages.	ros	121-124	NLR family, pyrin domain containing 3	Mus musculus	125-130
32470468-9	2020	Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H2O2-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 macrophages, which were abrogated by Met treatment.	Hydrogen Peroxide	74-91	NLR family, pyrin domain containing 3	Mus musculus	180-185
32470468-9	2020	Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H2O2-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 macrophages, which were abrogated by Met treatment.	Hydrogen Peroxide	98-102	NLR family, pyrin domain containing 3	Mus musculus	180-185
32622527-0	2020	Xenon blunts NF-kappaB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice.	Xenon	0-5	NLR family, pyrin domain containing 3	Mus musculus	23-28
32470468-9	2020	Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H2O2-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 macrophages, which were abrogated by Met treatment.	Adenosine Triphosphate	136-139	NLR family, pyrin domain containing 3	Mus musculus	180-185
32622527-5	2020	The effects of xenon were mediated primarily by deceasing serum levels of anti-double stranded DNA autoantibody, inhibiting reactive oxygen species production, NF-kappaB/NLRP3 inflammasome activation, ICAM-1 expression, glomerular deposition of IgG and C3 and apoptosis, in the kidney; and enhancing renal hypoxia inducible factor 1-alpha expression.	Xenon	15-20	NLR family, pyrin domain containing 3	Mus musculus	170-175
32622527-6	2020	Proteomic analysis revealed that the treatment with xenon downregulated renal NLRP3 inflammasome-mediated cellular signaling.	Xenon	52-57	NLR family, pyrin domain containing 3	Mus musculus	78-83
32461025-0	2020	Dysfunctional Nurr1 promotes high glucose-induced Muller cell activation by up-regulating the NF-kappaB/NLRP3 inflammasome axis.	Glucose	34-41	NLR family, pyrin domain containing 3	Mus musculus	104-109
32461025-5	2020	In vitro, Nurr1 expression and nuclear translocation decreased in Muller cells exposed to high glucose levels; therefore, p65 was activated, and the downstream NLRP3 inflammasome was up-regulated via the interaction of p65 with its promoter.	Glucose	95-102	NLR family, pyrin domain containing 3	Mus musculus	160-165
32849566-0	2020	Supraphysiological Levels of Testosterone Induce Vascular Dysfunction via Activation of the NLRP3 Inflammasome.	Testosterone	29-41	NLR family, pyrin domain containing 3	Mus musculus	92-97
32428667-0	2020	Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis.	lycorine	0-8	NLR family, pyrin domain containing 3	Mus musculus	73-78
32428667-0	2020	Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis.	Bleomycin	21-30	NLR family, pyrin domain containing 3	Mus musculus	73-78
32428667-6	2020	Furthermore, our in vitro assay showed that LYC inhibited LPS/Nigericin- or LPS/ATP-induced NACHT, LRP and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pyroptosis in bone marrow-derived macrophages (BMDMs).	Nigericin	62-71	NLR family, pyrin domain containing 3	Mus musculus	141-146
32428667-6	2020	Furthermore, our in vitro assay showed that LYC inhibited LPS/Nigericin- or LPS/ATP-induced NACHT, LRP and PYD domains-containing protein 3 (NLRP3) inflammasome activation, and pyroptosis in bone marrow-derived macrophages (BMDMs).	Adenosine Triphosphate	80-83	NLR family, pyrin domain containing 3	Mus musculus	141-146
32849566-4	2020	We hypothesized that supraphysiological levels of testosterone, via generation of mitochondrial reactive oxygen species (mROS), activates the NLRP3 inflammasome and promotes vascular dysfunction.	Testosterone	50-62	NLR family, pyrin domain containing 3	Mus musculus	142-147
32849566-4	2020	We hypothesized that supraphysiological levels of testosterone, via generation of mitochondrial reactive oxygen species (mROS), activates the NLRP3 inflammasome and promotes vascular dysfunction.	Reactive Oxygen Species	96-119	NLR family, pyrin domain containing 3	Mus musculus	142-147
32849566-14	2020	Conclusion: Supraphysiological levels of testosterone induce vascular dysfunction via mROS generation and NLRP3 inflammasome activation.	Testosterone	41-53	NLR family, pyrin domain containing 3	Mus musculus	106-111
32656558-0	2020	Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway.	oleuropein	8-18	NLR family, pyrin domain containing 3	Mus musculus	164-169
32722183-0	2020	A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway.	epoxydocosapentaenoic acid	12-38	NLR family, pyrin domain containing 3	Mus musculus	130-135
32722183-7	2020	Improved postischemic functional recovery, maintained cardiac ATP levels, reduced oxidative stress and attenuation of NLRP3 activation were observed in hearts perfused with the analogue SA-26.	sa-26	186-191	NLR family, pyrin domain containing 3	Mus musculus	118-123
32722183-9	2020	Together, these data demonstrate that the cardioprotective effects of the EDP analogue SA-26 against IR injury involve preservation of mitochondrial SIRT3 activity, which attenuates a detrimental innate NLRP3 inflammasome response.	sa-26	87-92	NLR family, pyrin domain containing 3	Mus musculus	203-208
32291445-7	2020	Inhibition of NLRP3 inflammosome reversed TMAO-stimulated M1 features, indicating that NLRP3 is the key proteolytic activator involved in macrophage"s response to TMAO stimulation.	trimethyloxamine	42-46	NLR family, pyrin domain containing 3	Mus musculus	14-19
32291445-7	2020	Inhibition of NLRP3 inflammosome reversed TMAO-stimulated M1 features, indicating that NLRP3 is the key proteolytic activator involved in macrophage"s response to TMAO stimulation.	trimethyloxamine	42-46	NLR family, pyrin domain containing 3	Mus musculus	87-92
32291445-7	2020	Inhibition of NLRP3 inflammosome reversed TMAO-stimulated M1 features, indicating that NLRP3 is the key proteolytic activator involved in macrophage"s response to TMAO stimulation.	trimethyloxamine	163-167	NLR family, pyrin domain containing 3	Mus musculus	14-19
32291445-7	2020	Inhibition of NLRP3 inflammosome reversed TMAO-stimulated M1 features, indicating that NLRP3 is the key proteolytic activator involved in macrophage"s response to TMAO stimulation.	trimethyloxamine	163-167	NLR family, pyrin domain containing 3	Mus musculus	87-92
32291445-9	2020	In vivo depletion of NLRP3 in GVHD recipients not only blocked M1 polarization but also reversed GVHD severity in the presence of TMAO treatment.	trimethyloxamine	130-134	NLR family, pyrin domain containing 3	Mus musculus	21-26
32291445-10	2020	In conclusion, our data revealed that TMAO-induced GVHD progression is resulted from Th1 and Th17 differentiation, which is mediated by polarized M1 macrophage requiring NLRP3 inflammasome activation.	trimethyloxamine	38-42	NLR family, pyrin domain containing 3	Mus musculus	170-175
32628479-0	2020	Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis.	callicarpins	0-12	NLR family, pyrin domain containing 3	Mus musculus	99-104
32628479-0	2020	Callicarpins, Two Classes of Rearranged ent-Clerodane Diterpenoids from Callicarpa Plants Blocking NLRP3 Inflammasome-Induced Pyroptosis.	Diterpenes	54-66	NLR family, pyrin domain containing 3	Mus musculus	99-104
32698512-0	2020	Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-kappaB-NLRP3 Pathway.	kmu-470	60-67	NLR family, pyrin domain containing 3	Mus musculus	114-119
32707926-0	2020	Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages.	Imiquimod	48-57	NLR family, pyrin domain containing 3	Mus musculus	97-102
32707926-6	2020	Notably, TCLPA5 administration attenuated the upregulation of macrophage NLRP3 in injured skin of mice with imiquimod-induced psoriasis.	TC LPA5 4	9-15	NLR family, pyrin domain containing 3	Mus musculus	73-78
32707926-6	2020	Notably, TCLPA5 administration attenuated the upregulation of macrophage NLRP3 in injured skin of mice with imiquimod-induced psoriasis.	Imiquimod	108-117	NLR family, pyrin domain containing 3	Mus musculus	73-78
32707926-8	2020	LPA exposure activated NLRP3 inflammasome in lipopolysaccharide-primed cells, which was evidenced by NLRP3 upregulation, caspase-1 activation, and IL-1beta maturation/secretion.	lysophosphatidic acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	23-28
32707926-8	2020	LPA exposure activated NLRP3 inflammasome in lipopolysaccharide-primed cells, which was evidenced by NLRP3 upregulation, caspase-1 activation, and IL-1beta maturation/secretion.	lysophosphatidic acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	101-106
32707926-9	2020	This LPA-driven NLRP3 inflammasome activation in lipopolysaccharide-primed cells was significantly attenuated upon LPA5 knockdown.	lysophosphatidic acid	5-8	NLR family, pyrin domain containing 3	Mus musculus	16-21
32792941-8	2020	CoQ10 also decreased the levels of related inflammatory factors (ICAM-1, VCAM-1, IL-6, TNF-alpha and NLRP3).	coenzyme Q10	0-5	NLR family, pyrin domain containing 3	Mus musculus	101-106
32698512-6	2020	Notably, KMU-470 inhibited LPS-induced up-regulation of a major component of the inflammasome complex, NLRP3, in RAW 264.7 cells.	kmu-470	9-16	NLR family, pyrin domain containing 3	Mus musculus	103-108
32680528-12	2020	CONCLUSIONS: Dopaminergic neurons have the potential to accumulate NLRP3 inflammasome activators with age, including reactive oxygen species, dopamine metabolites, and misfolded proteins.	Oxygen	126-132	NLR family, pyrin domain containing 3	Mus musculus	67-72
32788872-6	2020	Interestingly, pretreatment with the caspase-12-specific inhibitor Z-ATAD-FMK attenuated cell injury and apoptosis and decreased the levels of NLRP3, caspase-1, IL-1beta, and cleaved caspase-3 in the OGD group.	z-atad-fmk	67-77	NLR family, pyrin domain containing 3	Mus musculus	143-148
32680528-12	2020	CONCLUSIONS: Dopaminergic neurons have the potential to accumulate NLRP3 inflammasome activators with age, including reactive oxygen species, dopamine metabolites, and misfolded proteins.	Dopamine	142-150	NLR family, pyrin domain containing 3	Mus musculus	67-72
31712142-9	2020	Taken together, Myr exhibits a protective role against LPS/D-GalN-induced FH by suppressing hepatic apoptosis, inflammation, and oxidative stress, likely involving in the regulation of apoptosis-related protein, TLR4-NF-kappaB/-MAPK and NLRP3 inflammasome, and AMPK-Nrf2/HO-1 signaling pathway.	myricetin	16-19	NLR family, pyrin domain containing 3	Mus musculus	237-242
32774726-6	2020	We also verified, through an in vitro simulation of the excitatory toxicity of glutamate and aging effects, that the activation of NLRP3 inflammasome plays a vital role in the cochlear ribbon synaptic damage.	Glutamic Acid	79-88	NLR family, pyrin domain containing 3	Mus musculus	131-136
32646056-0	2020	Juglone Suppresses LPS-induced Inflammatory Responses and NLRP3 Activation in Macrophages.	juglone	0-7	NLR family, pyrin domain containing 3	Mus musculus	58-63
32646056-3	2020	The aim of this study was to explore the effects of juglone (5-hydroxyl-1,4-naphthoquinone) on NLRP3 inflammasome activation.	juglone	52-59	NLR family, pyrin domain containing 3	Mus musculus	95-100
32646056-3	2020	The aim of this study was to explore the effects of juglone (5-hydroxyl-1,4-naphthoquinone) on NLRP3 inflammasome activation.	5-hydroxyl-1,4-naphthoquinone	61-90	NLR family, pyrin domain containing 3	Mus musculus	95-100
32646056-8	2020	The levels of NLRP3 and cleaved caspase-1, as well as the secretion of IL-1beta and IL-18, were decreased by treatment with juglone in a concentration-dependent manner.	juglone	124-131	NLR family, pyrin domain containing 3	Mus musculus	14-19
32646056-9	2020	Juglone also inhibited the ATPase activities of NLRP3 in LPS/ATP-stimulated J774.1 macrophages.	juglone	0-7	NLR family, pyrin domain containing 3	Mus musculus	48-53
32646056-9	2020	Juglone also inhibited the ATPase activities of NLRP3 in LPS/ATP-stimulated J774.1 macrophages.	Adenosine Triphosphate	27-30	NLR family, pyrin domain containing 3	Mus musculus	48-53
32646056-10	2020	Our results suggested that juglone could inhibit inflammatory cytokine production and NLRP3 inflammasome activation in macrophages, and should be considered as a therapeutic strategy for inflammation-related diseases.	juglone	27-34	NLR family, pyrin domain containing 3	Mus musculus	86-91
32352641-3	2020	Here, we report that in mouse airway epithelial cells (AECs), inflammasome activation is inhibited by EphA2, a member of the transmembrane tyrosine kinase receptor family, via tyrosine phosphorylation of NLRP3 in a model of reovirus infection.	Tyrosine	139-147	NLR family, pyrin domain containing 3	Mus musculus	204-209
32311670-10	2020	p53 may mediate the anti-inflammation effect of 10-HDAA in two ways: first by directly deactivating the NLRP3 inflammatory pathway, second by indirectly promoting autophagy.	10-hydroxydecanoic acid	48-55	NLR family, pyrin domain containing 3	Mus musculus	104-109
32134203-7	2020	RESULTS: beta-Carotene (provitamin A) suppressed the NLRP3 inflammasome activation induced by various activators including MSU crystals, in mouse bone marrow-derived primary macrophages (p<0.05).	beta Carotene	9-22	NLR family, pyrin domain containing 3	Mus musculus	53-58
32134203-7	2020	RESULTS: beta-Carotene (provitamin A) suppressed the NLRP3 inflammasome activation induced by various activators including MSU crystals, in mouse bone marrow-derived primary macrophages (p<0.05).	beta Carotene	24-36	NLR family, pyrin domain containing 3	Mus musculus	53-58
32134203-8	2020	Surface plasmon resonance analysis demonstrated the direct binding of beta-carotene to the pyrin domain (PYD) of NLRP3 (KD =3.41E-06).	beta Carotene	70-83	NLR family, pyrin domain containing 3	Mus musculus	113-118
32134203-9	2020	Molecular modeling and mutation assays revealed the interaction mode between beta-carotene and the NLRP3 PYD.	beta Carotene	77-90	NLR family, pyrin domain containing 3	Mus musculus	99-104
32134203-10	2020	Inflammatory symptoms induced by MSU crystals were attenuated by oral administration of beta-carotene in gouty arthritis mouse models (p<0.05), correlating with its suppressive effects on the NLRP3 inflammasome in inflamed tissues.	beta Carotene	88-101	NLR family, pyrin domain containing 3	Mus musculus	192-197
32353421-9	2020	NEK7 is a vital mediator of NLRP3 inflammasome activation, and glibenclamide or oridonin may be candidates for the development of new therapeutics against VILI driven by the interaction between NEK7 and NLRP3.	oridonin	80-88	NLR family, pyrin domain containing 3	Mus musculus	203-208
32559840-4	2020	Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Containing 3 (NLRP3) immunoreactivity in Iba1-labled microglia together with total Iba1 and NLRP3 expression in the brain following tMCAO, while down-regulated by CEP treatment.	tmcao	211-216	NLR family, pyrin domain containing 3	Mus musculus	55-91
32559840-4	2020	Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Containing 3 (NLRP3) immunoreactivity in Iba1-labled microglia together with total Iba1 and NLRP3 expression in the brain following tMCAO, while down-regulated by CEP treatment.	tmcao	211-216	NLR family, pyrin domain containing 3	Mus musculus	93-98
32559840-4	2020	Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Containing 3 (NLRP3) immunoreactivity in Iba1-labled microglia together with total Iba1 and NLRP3 expression in the brain following tMCAO, while down-regulated by CEP treatment.	cepharanthine	242-245	NLR family, pyrin domain containing 3	Mus musculus	55-91
32559840-4	2020	Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Containing 3 (NLRP3) immunoreactivity in Iba1-labled microglia together with total Iba1 and NLRP3 expression in the brain following tMCAO, while down-regulated by CEP treatment.	cepharanthine	242-245	NLR family, pyrin domain containing 3	Mus musculus	93-98
32559840-5	2020	In both tMCAO-induced mice and OGD/R-treated BV-2 cells, CEP exhibited dose-dependent inhibition on the expression of NLRP3, ASC and cleaved caspase-1.	cepharanthine	57-60	NLR family, pyrin domain containing 3	Mus musculus	118-123
32407725-2	2020	Retinal Muller cells proliferate and produce pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via the reactive oxygen species (ROS)/thioredoxin interacting protein (TXNIP)/NACHT, LRR and PYD domain-containing protein 3 (NLRP3) inflammasome axis to promote proliferative DR. Epigallocatechin-3-gallate (EGCG) plays anti-oxidant, anti-inflammatory, anti-proliferative and anti-angiogenic roles in Muller cells.	Reactive Oxygen Species	165-188	NLR family, pyrin domain containing 3	Mus musculus	283-288
32407725-2	2020	Retinal Muller cells proliferate and produce pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via the reactive oxygen species (ROS)/thioredoxin interacting protein (TXNIP)/NACHT, LRR and PYD domain-containing protein 3 (NLRP3) inflammasome axis to promote proliferative DR. Epigallocatechin-3-gallate (EGCG) plays anti-oxidant, anti-inflammatory, anti-proliferative and anti-angiogenic roles in Muller cells.	Reactive Oxygen Species	190-193	NLR family, pyrin domain containing 3	Mus musculus	283-288
32407725-4	2020	In an in vitro model of high glucose-stimulated Muller cells, pro-EGCG inhibited proliferation and pro-angiogenic factor production by down-regulating the activity of the ROS/TXNIP/NLRP3 inflammasome axis.	Glucose	29-36	NLR family, pyrin domain containing 3	Mus musculus	181-186
32407725-4	2020	In an in vitro model of high glucose-stimulated Muller cells, pro-EGCG inhibited proliferation and pro-angiogenic factor production by down-regulating the activity of the ROS/TXNIP/NLRP3 inflammasome axis.	pro-egcg	62-70	NLR family, pyrin domain containing 3	Mus musculus	181-186
32407725-5	2020	In a mouse DR model, pro-EGCG reduced ROS accumulation, NLRP3 inflammasome activation, Muller cell proliferation, and production of the pro-angiogenic factors VEGF and HGF.	pro-egcg	21-29	NLR family, pyrin domain containing 3	Mus musculus	56-61
32407725-6	2020	In summary, pro-EGCG mitigated hyperglycaemia-challenged Muller cell proliferation and pro-angiogenic factor production by inhibiting ROS/TXNIP/NLRP3 inflammasome signalling, implying a potential therapeutic strategy for DR.	pro-egcg	12-20	NLR family, pyrin domain containing 3	Mus musculus	144-149
32350570-0	2020	Hydrogen attenuates sepsis-associated encephalopathy by NRF2 mediated NLRP3 pathway inactivation.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	70-75
32350570-15	2020	Hydrogen increased Nrf2 expression and inhibited the SAE-induced expression of NLRP3, caspase-1, cytokines IL-1beta and IL-18, neuronal apoptosis, and mitochondrial dysfunction in WT mice but not Nrf2 KO mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	79-84
32350570-17	2020	Hydrogen alleviated inflammation, neuronal apoptosis and mitochondrial dysfunction via inhibiting Nrf2-mediated NLRP3 pathway.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	112-117
32353421-0	2020	NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury.	Potassium	74-83	NLR family, pyrin domain containing 3	Mus musculus	41-46
32353421-7	2020	Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux.	Potassium	142-151	NLR family, pyrin domain containing 3	Mus musculus	64-69
32353421-7	2020	Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux.	Potassium	142-151	NLR family, pyrin domain containing 3	Mus musculus	109-114
32353421-8	2020	NEK7 depletion and treatment with glibenclamide or oridonin exerted anti-inflammatory effects that alleviated VILI by blocking the interaction between NEK7 and NLRP3, inhibiting NLRP3 inflammasome activation.	Glyburide	34-47	NLR family, pyrin domain containing 3	Mus musculus	160-165
32353421-8	2020	NEK7 depletion and treatment with glibenclamide or oridonin exerted anti-inflammatory effects that alleviated VILI by blocking the interaction between NEK7 and NLRP3, inhibiting NLRP3 inflammasome activation.	Glyburide	34-47	NLR family, pyrin domain containing 3	Mus musculus	178-183
32353421-8	2020	NEK7 depletion and treatment with glibenclamide or oridonin exerted anti-inflammatory effects that alleviated VILI by blocking the interaction between NEK7 and NLRP3, inhibiting NLRP3 inflammasome activation.	oridonin	51-59	NLR family, pyrin domain containing 3	Mus musculus	160-165
32353421-8	2020	NEK7 depletion and treatment with glibenclamide or oridonin exerted anti-inflammatory effects that alleviated VILI by blocking the interaction between NEK7 and NLRP3, inhibiting NLRP3 inflammasome activation.	oridonin	51-59	NLR family, pyrin domain containing 3	Mus musculus	178-183
32353421-9	2020	NEK7 is a vital mediator of NLRP3 inflammasome activation, and glibenclamide or oridonin may be candidates for the development of new therapeutics against VILI driven by the interaction between NEK7 and NLRP3.	Glyburide	63-76	NLR family, pyrin domain containing 3	Mus musculus	203-208
32407725-0	2020	A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Muller cells.	epigallocatechin gallate	13-39	NLR family, pyrin domain containing 3	Mus musculus	133-138
32407725-0	2020	A prodrug of epigallocatechin-3-gallate alleviates high glucose-induced pro-angiogenic factor production by inhibiting the ROS/TXNIP/NLRP3 inflammasome axis in retinal Muller cells.	Glucose	56-63	NLR family, pyrin domain containing 3	Mus musculus	133-138
32361652-0	2020	Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation.	geniposide	0-10	NLR family, pyrin domain containing 3	Mus musculus	20-25
32361652-6	2020	This study aimed to evaluate whether geniposide could inhibit the expression and activation of NLRP3 inflammasome in BV-2 microglial cells following oxygen-glucose deprivation/reoxygenation (OGD/R) and assessed whether autophagy is involved in this process.	geniposide	37-47	NLR family, pyrin domain containing 3	Mus musculus	95-100
32361652-6	2020	This study aimed to evaluate whether geniposide could inhibit the expression and activation of NLRP3 inflammasome in BV-2 microglial cells following oxygen-glucose deprivation/reoxygenation (OGD/R) and assessed whether autophagy is involved in this process.	Oxygen	149-155	NLR family, pyrin domain containing 3	Mus musculus	95-100
32361652-9	2020	The results demonstrated geniposide decreased cell death and the levels of NLRP3, ASC, cleaved- caspase-1 and IL-1beta, whereas significantly increased the conversion of LC3 and Beclin-1 expression, decreased the expression of P62.	geniposide	25-35	NLR family, pyrin domain containing 3	Mus musculus	75-80
32361652-10	2020	Taken together, our results suggested that the effect of geniposide could be ascribed to the reduction of the level of inflammatory cytokines via inhibiting the activation and expression of NLRP3 inflammasome and increasing autophagic activity following OGD/R in BV-2 microglial cells.	geniposide	57-67	NLR family, pyrin domain containing 3	Mus musculus	190-195
32402951-0	2020	Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.	neferine	0-8	NLR family, pyrin domain containing 3	Mus musculus	96-101
32402952-4	2020	Therefore, we aimed to explore the cytotoxic effects of cigarette smoke condensate (CSC) on the activation of NLRP3 inflammasome in vitro and in vivo.	cigarette smoke condensate	56-82	NLR family, pyrin domain containing 3	Mus musculus	110-115
32325405-6	2020	In vitro, bilirubin inhibited caspase-1 maturation and IL-1beta secretion in NLRP3, AIM2, and NLRC4 inflammasomes.	Bilirubin	10-19	NLR family, pyrin domain containing 3	Mus musculus	77-82
32402952-4	2020	Therefore, we aimed to explore the cytotoxic effects of cigarette smoke condensate (CSC) on the activation of NLRP3 inflammasome in vitro and in vivo.	8-(3-Chlorostyryl)caffeine	84-87	NLR family, pyrin domain containing 3	Mus musculus	110-115
32361652-11	2020	We provided a new understanding of geniposide in neuroprotection by activating autophagy and promoting anti-inflammation inhibiting NLRP3 inflammasome in microglial cells.	geniposide	35-45	NLR family, pyrin domain containing 3	Mus musculus	132-137
32083340-0	2020	Paeoniflorin relieves LPS-induced inflammatory pain in mice by inhibiting NLRP3 inflammasome activation via transient receptor potential vanilloid 1.	peoniflorin	0-12	NLR family, pyrin domain containing 3	Mus musculus	74-79
32323562-0	2020	PKM2 Activator TEPP-46 Attenuates Thoracic Aortic Aneurysm and Dissection by Inhibiting NLRP3 Inflammasome-Mediated IL-1beta Secretion.	TEPP-46	15-22	NLR family, pyrin domain containing 3	Mus musculus	88-93
32323562-7	2020	Furthermore, TEPP-46 treatment also suppressed the activation of the NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome by downregulating p-STAT3 and HIF1-alpha.	TEPP-46	13-20	NLR family, pyrin domain containing 3	Mus musculus	139-144
32347580-2	2020	The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC.	4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine	24-27	NLR family, pyrin domain containing 3	Mus musculus	259-264
32237257-0	2020	1,25(OH)2 D3 alleviates DSS-induced ulcerative colitis via inhibiting NLRP3 inflammasome activation.	1,25(oh)2	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
32273259-4	2020	Doxorubicin (Dox)-induced DCM characterization disclosed that NLRP3 inflammasome activation and pyroptosis occurred in Dox-treated heart tissues, but were very marginal in either NLRP3-/- or caspase-1-/- mice.	Doxorubicin	0-11	NLR family, pyrin domain containing 3	Mus musculus	62-67
32538511-1	2020	OBJECTIVE: This study aimed to investigate whether the NLRP3 inflammasome in Kupffer cells (KCs) can be activated in response to high glucose (HG) and to evaluate its influence on hepatic insulin sensitivity.	Glucose	134-141	NLR family, pyrin domain containing 3	Mus musculus	55-60
32438202-6	2020	RESULTS: We found ROS-NLRP3 singaling was activated in BV2 cells at OGD/R 24 h. Importantly, microglial NLRP3 activation was essential for NLRP3 activation in PC12 cells under microglial-neuronal co-culture circumstance, which has been confirmed to induced neuronal apoptosis.	ros	18-21	NLR family, pyrin domain containing 3	Mus musculus	22-27
32273259-4	2020	Doxorubicin (Dox)-induced DCM characterization disclosed that NLRP3 inflammasome activation and pyroptosis occurred in Dox-treated heart tissues, but were very marginal in either NLRP3-/- or caspase-1-/- mice.	Doxorubicin	0-3	NLR family, pyrin domain containing 3	Mus musculus	62-67
32273259-4	2020	Doxorubicin (Dox)-induced DCM characterization disclosed that NLRP3 inflammasome activation and pyroptosis occurred in Dox-treated heart tissues, but were very marginal in either NLRP3-/- or caspase-1-/- mice.	Doxorubicin	13-16	NLR family, pyrin domain containing 3	Mus musculus	62-67
32273259-5	2020	Mechanistically, Dox enhanced expressions of NOX1 and NOX4 and induced mitochondrial fission through dynamin-related protein 1 (Drp1) activation, leading to NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes via caspase-1-dependent manner.	Doxorubicin	17-20	NLR family, pyrin domain containing 3	Mus musculus	157-162
32273259-8	2020	Importantly, Dox-induced Drp1-mediated mitochondrial fission and the consequent NLRP3 inflammasome activation and pyroptosis were reversed by NOX1 and NOX4 inhibition in mice.	Doxorubicin	13-16	NLR family, pyrin domain containing 3	Mus musculus	80-85
32325423-7	2020	Moreover, SRT1720 regulates PDH-related glucose oxidative metabolism to reduce NLRP3 inflammasome activation and pyroptosis in an Akt signaling dependent manner during I/R.	Glucose	40-47	NLR family, pyrin domain containing 3	Mus musculus	79-84
32321163-10	2020	These results indicate that following triclosan exposure, activation of the NLRP3 inflammasome occurs in both the skin tissue and dLNs, providing a possible mechanism for triclosan"s effects on allergic disease and further support a connection between mitochondrial involvement in immunological responses.	Triclosan	38-47	NLR family, pyrin domain containing 3	Mus musculus	76-81
32321163-10	2020	These results indicate that following triclosan exposure, activation of the NLRP3 inflammasome occurs in both the skin tissue and dLNs, providing a possible mechanism for triclosan"s effects on allergic disease and further support a connection between mitochondrial involvement in immunological responses.	Triclosan	171-180	NLR family, pyrin domain containing 3	Mus musculus	76-81
32630144-2	2020	Here we describe how low concentrations of UTP and ATP applied during macrophage priming enhance IL-1beta production when subsequently the NLRP3 inflammasome is activated in murine resident peritoneal macrophages.	Uridine Triphosphate	43-46	NLR family, pyrin domain containing 3	Mus musculus	139-144
32413745-0	2020	Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	72-77
32413745-0	2020	Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation.	Morphine	21-29	NLR family, pyrin domain containing 3	Mus musculus	72-77
32413745-4	2020	There was a significant activation of the NLRP3 inflammasome in the prefrontal cortex and the peripheral blood of morphine-treated mice compared to control animals, which could be blocked by melatonin.	Morphine	114-122	NLR family, pyrin domain containing 3	Mus musculus	42-47
32413745-4	2020	There was a significant activation of the NLRP3 inflammasome in the prefrontal cortex and the peripheral blood of morphine-treated mice compared to control animals, which could be blocked by melatonin.	Melatonin	191-200	NLR family, pyrin domain containing 3	Mus musculus	42-47
32630144-2	2020	Here we describe how low concentrations of UTP and ATP applied during macrophage priming enhance IL-1beta production when subsequently the NLRP3 inflammasome is activated in murine resident peritoneal macrophages.	Adenosine Triphosphate	51-54	NLR family, pyrin domain containing 3	Mus musculus	139-144
32413745-6	2020	SiRNA knockdown or pharmacological inhibition of the NLRP3 abolished the morphine-induced inflammasome activation.	Morphine	73-81	NLR family, pyrin domain containing 3	Mus musculus	53-58
32636719-0	2020	The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice.	Resveratrol	25-36	NLR family, pyrin domain containing 3	Mus musculus	94-100
32413745-7	2020	Co-administration of melatonin and low-dose morphine had better analgesia effects in the murine models of pain and led to a lower NLRP3 inflammasome activity in brain tissues.	Melatonin	21-30	NLR family, pyrin domain containing 3	Mus musculus	130-135
32413745-7	2020	Co-administration of melatonin and low-dose morphine had better analgesia effects in the murine models of pain and led to a lower NLRP3 inflammasome activity in brain tissues.	Morphine	44-52	NLR family, pyrin domain containing 3	Mus musculus	130-135
32413745-8	2020	Mice deficient for Nlrp3 had a higher nociceptive threshold and were less sensitive to develop morphine-induced analgesic tolerance and acetic acid-induced pain relative to wild-type animals.	Morphine	95-103	NLR family, pyrin domain containing 3	Mus musculus	19-24
32413745-8	2020	Mice deficient for Nlrp3 had a higher nociceptive threshold and were less sensitive to develop morphine-induced analgesic tolerance and acetic acid-induced pain relative to wild-type animals.	Acetic Acid	136-147	NLR family, pyrin domain containing 3	Mus musculus	19-24
32636719-6	2020	In conclusion, this study confirms resveratrol acts against radiation-induced inflammatory bowel disease via NLRP-3 inflammasome repression in mice and supports Sirt1 as a potential biomarker and therapy target in intestinal radiation protection.	Resveratrol	35-46	NLR family, pyrin domain containing 3	Mus musculus	109-115
32539054-9	2020	In conclusion, these data demonstrate that KD decreased the reactive astrocytes and activated the microglia in the corpus callosum, and that KD inhibited the HADC3 and NLRP3 inflammasome signaling pathway in CPZ-treated mice.	Chlorpromazine	208-211	NLR family, pyrin domain containing 3	Mus musculus	168-173
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Methionine	286-296	NLR family, pyrin domain containing 3	Mus musculus	57-62
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Methionine	286-296	NLR family, pyrin domain containing 3	Mus musculus	88-93
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Methionine	286-296	NLR family, pyrin domain containing 3	Mus musculus	88-93
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Choline	297-304	NLR family, pyrin domain containing 3	Mus musculus	57-62
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Choline	297-304	NLR family, pyrin domain containing 3	Mus musculus	88-93
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Choline	297-304	NLR family, pyrin domain containing 3	Mus musculus	88-93
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Carbon Tetrachloride	337-357	NLR family, pyrin domain containing 3	Mus musculus	57-62
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Carbon Tetrachloride	337-357	NLR family, pyrin domain containing 3	Mus musculus	88-93
32695095-4	2020	Here, we found significantly elevated gene expression of NLRP3 inflammasome components (NLRP3, pro-interleukin-1beta, and pro-interleukin-18) and the activation of NLRP3 inflammasome significantly elevated during murine chronic liver injury induced by a bile duct ligation operation, a methionine-choline-deficient and high-fat diet, or carbon tetrachloride intraperitoneal injection.	Carbon Tetrachloride	337-357	NLR family, pyrin domain containing 3	Mus musculus	88-93
32595419-0	2020	NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-kappaB/COX-2/PG pathway.	pg	100-102	NLR family, pyrin domain containing 3	Mus musculus	0-5
32557012-13	2021	In particular, the expression of SIRT3, SOD2, and NLRP3 was significantly regulated in the idebenone treatment groups compared with the HFD group both in vivo and in vitro.	idebenone	91-100	NLR family, pyrin domain containing 3	Mus musculus	50-55
32476536-1	2020	Background Aberrant activation of the NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat-containing receptor family pyrin domain-containing 3) inflammasome is thought to play a causative role in atherosclerosis.	Leucine	88-95	NLR family, pyrin domain containing 3	Mus musculus	38-43
32625078-0	2020	Genistein Attenuates Acute Cerebral Ischemic Damage by Inhibiting the NLRP3 Inflammasome in Reproductively Senescent Mice.	Genistein	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
32538180-0	2020	Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.	Sevoflurane	0-11	NLR family, pyrin domain containing 3	Mus musculus	49-54
32268154-0	2020	Cordycepin protects against acute pancreatitis by modulating NF-kappaB and NLRP3 inflammasome activation via AMPK.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	75-80
31937929-0	2020	Oroxindin inhibits macrophage NLRP3 inflammasome activation in DSS-induced ulcerative colitis in mice via suppressing TXNIP-dependent NF-kappaB pathway.	oroxindin	0-9	NLR family, pyrin domain containing 3	Mus musculus	30-35
32101829-0	2020	Palmitic acid activates NLRP3 inflammasome and induces placental inflammation during pregnancy in mice.	Palmitic Acid	0-13	NLR family, pyrin domain containing 3	Mus musculus	24-29
32101829-8	2020	The administration of PA significantly increased IL-1beta protein and the mRNA expression of NLRP3 inflammasome components (NLRP3, ASC, and caspase-1) within the placenta.	Palmitic Acid	22-24	NLR family, pyrin domain containing 3	Mus musculus	93-98
32101829-8	2020	The administration of PA significantly increased IL-1beta protein and the mRNA expression of NLRP3 inflammasome components (NLRP3, ASC, and caspase-1) within the placenta.	Palmitic Acid	22-24	NLR family, pyrin domain containing 3	Mus musculus	124-129
32101829-9	2020	In murine placental cell culture, PA significantly stimulated IL-1beta secretion, and this secretion was suppressed by a specific NLRP3 inhibitor (MCC950).	Palmitic Acid	34-36	NLR family, pyrin domain containing 3	Mus musculus	130-135
32101829-9	2020	In murine placental cell culture, PA significantly stimulated IL-1beta secretion, and this secretion was suppressed by a specific NLRP3 inhibitor (MCC950).	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	147-153	NLR family, pyrin domain containing 3	Mus musculus	130-135
32101829-11	2020	Treatment with PA induced ASC assembling and IL-1beta secretion in macrophages, and this PA-induced IL-1beta secretion was significantly suppressed in NLRP3-knockout macrophages.	Palmitic Acid	15-17	NLR family, pyrin domain containing 3	Mus musculus	151-156
32101829-11	2020	Treatment with PA induced ASC assembling and IL-1beta secretion in macrophages, and this PA-induced IL-1beta secretion was significantly suppressed in NLRP3-knockout macrophages.	Palmitic Acid	89-91	NLR family, pyrin domain containing 3	Mus musculus	151-156
32101829-12	2020	These results indicate that transient higher levels of PA exposure in pregnant mice activates NLRP3 inflammasome and induces placental inflammation, resulting in the incidence of absorption.	Palmitic Acid	55-57	NLR family, pyrin domain containing 3	Mus musculus	94-99
32513156-0	2020	Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	0-8	NLR family, pyrin domain containing 3	Mus musculus	73-78
32513156-15	2020	The expression of NLRP3 inflammasome protein and NF-kappaB pathway were significantly inhibited by caffeine treatment.	Caffeine	99-107	NLR family, pyrin domain containing 3	Mus musculus	18-23
32513156-16	2020	CONCLUSION: Caffeine treatment can protect hyperoxia-induced mice lung from oxidative injury by inhibiting NLRP3 inflammasome and NF-kappaB pathway.	Caffeine	12-20	NLR family, pyrin domain containing 3	Mus musculus	107-112
31937929-7	2020	Furthermore, oroxindin treatment significantly inhibited the generation of IL-1beta and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome formation and activation.	oroxindin	13-22	NLR family, pyrin domain containing 3	Mus musculus	126-183
31937929-7	2020	Furthermore, oroxindin treatment significantly inhibited the generation of IL-1beta and IL-18 in the colon via inhibiting the nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) inflammasome formation and activation.	oroxindin	13-22	NLR family, pyrin domain containing 3	Mus musculus	185-190
31937929-8	2020	In cultured macrophages, LPS induced NLRP3 inflammasome formation and caspase-1 activation, which were suppressed by oroxindin (12.5-50 muM).	oroxindin	117-126	NLR family, pyrin domain containing 3	Mus musculus	37-42
31937929-10	2020	In conclusion, these results demonstrate that oroxindin could be absorbed by the colon and attenuate inflammatory responses via inhibiting NLRP3 inflammasome formation and activation, which is related to the inhibitory effect on TXNIP-dependent NF-kappaB-signaling pathway.	oroxindin	46-55	NLR family, pyrin domain containing 3	Mus musculus	139-144
32517686-0	2020	Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome.	ethyl pyruvate	0-14	NLR family, pyrin domain containing 3	Mus musculus	88-93
32517686-4	2020	We previously found that ethyl pyruvate (EP), a metabolite derivative, is able to effectively inhibit the NLRP3 inflammasome activation.	ethyl pyruvate	25-39	NLR family, pyrin domain containing 3	Mus musculus	106-111
32517686-4	2020	We previously found that ethyl pyruvate (EP), a metabolite derivative, is able to effectively inhibit the NLRP3 inflammasome activation.	ethyl pyruvate	41-43	NLR family, pyrin domain containing 3	Mus musculus	106-111
32517686-10	2020	To investigate the mechanisms by which ethyl pyruvate prevent SAE, the activation of NLRP3 in the hippocampus and the microglia were determined using western blotting, and cognitive function, microglia activation, and neurogenesis were assessed using WT, Nlrp3-/- and Asc-/- mice in the sublethal CLP model.	ethyl pyruvate	39-53	NLR family, pyrin domain containing 3	Mus musculus	85-90
32517686-13	2020	In addition, EP significantly decreased the NLRP3 level in the hippocampus of the CLP mice, and inhibited the cleavage of IL-1beta induced by NLRP3 inflammsome in microglia.	ethyl pyruvate	13-15	NLR family, pyrin domain containing 3	Mus musculus	44-49
32517686-13	2020	In addition, EP significantly decreased the NLRP3 level in the hippocampus of the CLP mice, and inhibited the cleavage of IL-1beta induced by NLRP3 inflammsome in microglia.	ethyl pyruvate	13-15	NLR family, pyrin domain containing 3	Mus musculus	142-147
32517686-17	2020	CONCLUSION: The results demonstrated that ethyl pyruvate confers protection against SAE through inhibiting the NLRP3 inflammasome.	ethyl pyruvate	42-56	NLR family, pyrin domain containing 3	Mus musculus	111-116
32408051-5	2020	CB1 expression was increased in liver tissue and macrophages of CCl4- and MCDHF-treated mice, positively correlated with NLRP3.	Carbon Tetrachloride	64-68	NLR family, pyrin domain containing 3	Mus musculus	121-126
32408051-6	2020	CB1 agonist ACEA (Arachiodonyl-2"-Chloroethylamide) promoted NLRP3 expression and NLRP3 inflammasome activation in macrophages.	arachidonyl-2-chloroethylamide	12-16	NLR family, pyrin domain containing 3	Mus musculus	61-66
32408051-6	2020	CB1 agonist ACEA (Arachiodonyl-2"-Chloroethylamide) promoted NLRP3 expression and NLRP3 inflammasome activation in macrophages.	arachidonyl-2-chloroethylamide	12-16	NLR family, pyrin domain containing 3	Mus musculus	82-87
32408051-6	2020	CB1 agonist ACEA (Arachiodonyl-2"-Chloroethylamide) promoted NLRP3 expression and NLRP3 inflammasome activation in macrophages.	arachiodonyl-2"-chloroethylamide	18-50	NLR family, pyrin domain containing 3	Mus musculus	61-66
32408051-6	2020	CB1 agonist ACEA (Arachiodonyl-2"-Chloroethylamide) promoted NLRP3 expression and NLRP3 inflammasome activation in macrophages.	arachiodonyl-2"-chloroethylamide	18-50	NLR family, pyrin domain containing 3	Mus musculus	82-87
32408051-7	2020	CB1 blockade with its antagonist AM281 reduced NLRP3 expression, inflammasome activation, and liver inflammation in CCl4- and MCDHF-treated mice.	AM 281	33-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
32108663-2	2020	Shingosine-1-phosphate is reported to evoke NLRP3 inflammasome activation.	shingosine-1-phosphate	0-22	NLR family, pyrin domain containing 3	Mus musculus	44-49
31768838-0	2020	Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy.	fluorescein diester	6-22	NLR family, pyrin domain containing 3	Mus musculus	50-55
31976546-12	2020	Consistent with Cnlp-/- mouse data, CRAMP administration suppressed renal I/R-induced NLRP3 inflammasome activation and its renal protective effects were mimicked by a specific NLRP3 inhibitor CY-09 treatment.	CY5.5 cyanine dye	193-198	NLR family, pyrin domain containing 3	Mus musculus	86-91
31976546-12	2020	Consistent with Cnlp-/- mouse data, CRAMP administration suppressed renal I/R-induced NLRP3 inflammasome activation and its renal protective effects were mimicked by a specific NLRP3 inhibitor CY-09 treatment.	CY5.5 cyanine dye	193-198	NLR family, pyrin domain containing 3	Mus musculus	177-182
32647664-8	2020	The inhibitory effect of CY09, an NLRP3 antagonist, efficiently abrogated the exacerbation effects of diabetes on liver IR injury in db/db mice.	CY5.5 cyanine dye	25-29	NLR family, pyrin domain containing 3	Mus musculus	34-39
32647664-10	2020	ROS scavenging by NAC pretreatment markedly inhibited hepatocellular NLRP3 inflammasome activation and pyroptosis in the db/db mice post-IR, indicating that ROS play an essential role in mediating hepatocyte pyroptosis in the setting of diabetes mellitus.	Reactive Oxygen Species	0-3	NLR family, pyrin domain containing 3	Mus musculus	69-74
32647664-10	2020	ROS scavenging by NAC pretreatment markedly inhibited hepatocellular NLRP3 inflammasome activation and pyroptosis in the db/db mice post-IR, indicating that ROS play an essential role in mediating hepatocyte pyroptosis in the setting of diabetes mellitus.	Reactive Oxygen Species	157-160	NLR family, pyrin domain containing 3	Mus musculus	69-74
32199914-0	2020	Propofol alleviates ventilator-induced lung injury through regulating the Nrf2/NLRP3 signaling pathway.	Propofol	0-8	NLR family, pyrin domain containing 3	Mus musculus	79-84
32114358-9	2020	Importantly, we found that PTUPB treatment suppressed the activation of NLRP3 inflammasome in the liver and lung of septic mice.	PTUPB	27-32	NLR family, pyrin domain containing 3	Mus musculus	72-77
32493060-8	2020	Lastly, addition of beta-hydroxybutyrate to isolated hearts was associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3)-inflammasome activation, which has been previously shown to play a role in contributing to HF-induced cardiac inflammation.	3-Hydroxybutyric Acid	20-40	NLR family, pyrin domain containing 3	Mus musculus	88-93
32493060-8	2020	Lastly, addition of beta-hydroxybutyrate to isolated hearts was associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3)-inflammasome activation, which has been previously shown to play a role in contributing to HF-induced cardiac inflammation.	3-Hydroxybutyric Acid	20-40	NLR family, pyrin domain containing 3	Mus musculus	95-144
32493060-10	2020	These beneficial effects of ketones were associated with reduced cardiac NLRP3 inflammasome activation, suggesting that ketones may modulate cardiac inflammation via this mechanism.	Ketones	28-35	NLR family, pyrin domain containing 3	Mus musculus	73-78
32493060-10	2020	These beneficial effects of ketones were associated with reduced cardiac NLRP3 inflammasome activation, suggesting that ketones may modulate cardiac inflammation via this mechanism.	Ketones	120-127	NLR family, pyrin domain containing 3	Mus musculus	73-78
32219880-0	2020	Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	99-104
32219880-0	2020	Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome.	Carbon Tetrachloride	21-41	NLR family, pyrin domain containing 3	Mus musculus	99-104
32219880-8	2020	The expression of NLRP3, caspase-1, and IL-1beta was downregulated with the oridonin treatment.	oridonin	76-84	NLR family, pyrin domain containing 3	Mus musculus	18-23
32219880-11	2020	Mechanically, oridonin may inhibit the activity of the NLRP3 inflammasome and inflammation in the liver.	oridonin	14-22	NLR family, pyrin domain containing 3	Mus musculus	55-60
32199914-2	2020	Herein, we discussed how propofol protects against VILI-induced inflammation with the interaction of nuclear factor E2-related factor 2 (Nrf2)/NOD-like receptor protein 3 (NLRP3).	Propofol	25-33	NLR family, pyrin domain containing 3	Mus musculus	172-177
32293760-7	2020	DSS activated the NLRP3-inflammasome and increased interleukin (IL)-1beta in the liver.	Dextran Sulfate	0-3	NLR family, pyrin domain containing 3	Mus musculus	18-23
32199914-5	2020	Propofol up-regulated Nrf2 and down-regulated NLRP3 in VILI model.	Propofol	0-8	NLR family, pyrin domain containing 3	Mus musculus	46-51
32199914-7	2020	Above all, we can conclude that propofol exerts it protective function against VILI and the subsequent inflammatory responses through activating Nrf2 and inhibiting NLRP3 expression.	Propofol	32-40	NLR family, pyrin domain containing 3	Mus musculus	165-170
32289481-6	2020	RESULT: Our study found that oroxylin A suppressed hepatocyte pyroptosis through a NLRP3 inflammasome dependent-canonical caspase-1 pathway.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	29-39	NLR family, pyrin domain containing 3	Mus musculus	83-88
32289481-7	2020	Results illuminated that oroxylin A inhibited NLRP3 inflammasome activation by reducing ROS accumulation.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	25-35	NLR family, pyrin domain containing 3	Mus musculus	46-51
32289481-7	2020	Results illuminated that oroxylin A inhibited NLRP3 inflammasome activation by reducing ROS accumulation.	ros	88-91	NLR family, pyrin domain containing 3	Mus musculus	46-51
32454347-11	2020	Daph inhibited inflammatory responses by inactivating the thioredoxin-interacting protein (Txnip)/NLRP3 inflammasome.	daphnetin	0-4	NLR family, pyrin domain containing 3	Mus musculus	98-103
32279044-6	2020	Furthermore, GL indirectly attenuated the expression of IL-1beta by directly inhibiting extracellular HMGB1 functions, which activated the NF-kappaB-p65/NLRP3/IL-1beta signalling pathway.	Glycyrrhizic Acid	13-15	NLR family, pyrin domain containing 3	Mus musculus	153-158
31860730-0	2020	Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome.	Aldosterone	8-19	NLR family, pyrin domain containing 3	Mus musculus	99-104
31860730-5	2020	Primary HSC isolated from C57BL/6 mice were treated with aldo, and the effects of aldo on NLRP3 inflammasome and HSC activation were detected in vitro.	Aldosterone	82-86	NLR family, pyrin domain containing 3	Mus musculus	90-95
31860730-8	2020	In vitro, aldo induced the activation of primary mouse HSCs by promoting the expression and assembly of NLRP3 inflammasome.	Aldosterone	10-14	NLR family, pyrin domain containing 3	Mus musculus	104-109
31860730-9	2020	In vivo, NLRP3 knockout could alleviate the liver fibrosis induced by aldo in mice.	Aldosterone	70-74	NLR family, pyrin domain containing 3	Mus musculus	9-14
31860730-10	2020	In addition, treatment with spironolactone (spi) could inhibit the NLRP3 expression, HSC activation, and liver fibrosis induced by CCl4 .	Spironolactone	28-42	NLR family, pyrin domain containing 3	Mus musculus	67-72
32385942-6	2020	Furthermore, AR-C17 treatment reduced neuroinflammation by inhibiting microglial activation and astrogliosis as well as decreasing NLRP3 inflammasome-mediated IL-1beta production and activating SIRT3/SOD2 signaling pathway.	ar-c17	13-19	NLR family, pyrin domain containing 3	Mus musculus	131-136
32259702-0	2020	NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson"s disease.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	107-111	NLR family, pyrin domain containing 3	Mus musculus	0-5
31860730-10	2020	In addition, treatment with spironolactone (spi) could inhibit the NLRP3 expression, HSC activation, and liver fibrosis induced by CCl4 .	Spironolactone	28-31	NLR family, pyrin domain containing 3	Mus musculus	67-72
32454347-0	2020	Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation.	daphnetin	34-43	NLR family, pyrin domain containing 3	Mus musculus	134-139
32454347-14	2020	CONCLUSIONS: These investigations demonstrated that Daph treatment has protective potential against oxidative stress-driven hepatotoxicity by inhibition of ASK1/JNK and Txnip/NLRP3 activation, which may be strongly related to the Nrf2/Trx-1 upregulation.	daphnetin	52-56	NLR family, pyrin domain containing 3	Mus musculus	175-180
32108749-2	2020	We aimed to explore the effects of the selective Nlrp3 inflammasome inhibitor MCC950 on the pathogenesis of OB.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	78-84	NLR family, pyrin domain containing 3	Mus musculus	49-54
32565873-0	2020	Oridonin Attenuates Myocardial Ischemia/Reperfusion Injury via Downregulating Oxidative Stress and NLRP3 Inflammasome Pathway in Mice.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	99-104
32179110-4	2020	When investigating the molecular mechanisms of QDs causing the inflammatory injury, the findings suggested that cadmium-containing QDs exposure activated NF-kappaB that participated in the NLRP3 inflammasome priming and pro-IL-1ss expression.	Cadmium	112-119	NLR family, pyrin domain containing 3	Mus musculus	189-194
32179110-5	2020	After that, QDs-induced excessive ROS generation triggered the NLRP3 inflammasome activation and resulted in active caspase-1 to process pro-IL-1ss into mature IL-1ss release and inflammatory cell death, i.e. pyroptosis.	ros	34-37	NLR family, pyrin domain containing 3	Mus musculus	63-68
32364698-0	2020	Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation.	astragalin	0-10	NLR family, pyrin domain containing 3	Mus musculus	80-85
32531700-9	2020	In vitro OGD/R induced the release of lactate dehydrogenase, promoted NLRP3 inflammasomes activation and pyroptosis in BV-2 cells, which was significantly suppressed by treatment with ginsenoside Rd (Rd) and Z-ligustilide (LIG).	Ginsenosides	184-195	NLR family, pyrin domain containing 3	Mus musculus	70-75
32566102-9	2020	In vivo, BBG significantly alleviated TAC-induced cardiac fibrosis, cardiac dysfunction, and NLRP3/IL-1beta activation.	coomassie Brilliant Blue	9-12	NLR family, pyrin domain containing 3	Mus musculus	93-98
32550919-0	2020	Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.	ros	94-97	NLR family, pyrin domain containing 3	Mus musculus	108-113
32081748-10	2020	In conclusion, our findings found that GE activated AMPKalpha to suppress myocardial ROS accumulation, thus blocking NLRP3 inflammasome-mediated cardiomyocyte apoptosis and pyroptosis and improving cardiac function in mice with sepsis.	ampkalpha	52-61	NLR family, pyrin domain containing 3	Mus musculus	117-122
32081748-10	2020	In conclusion, our findings found that GE activated AMPKalpha to suppress myocardial ROS accumulation, thus blocking NLRP3 inflammasome-mediated cardiomyocyte apoptosis and pyroptosis and improving cardiac function in mice with sepsis.	Reactive Oxygen Species	85-88	NLR family, pyrin domain containing 3	Mus musculus	117-122
32613145-3	2020	Thus, castration increased the dependency of atherosclerosis on the NLRP3 inflammasome, suggesting that testosterone may block inflammation in atherogenesis.	Testosterone	104-116	NLR family, pyrin domain containing 3	Mus musculus	68-73
32476784-4	2020	In hypoxic adipocytes, HIF-1alpha upregulates pla2g16 (a novel HIF-1alpha target gene) gene expression to activate the NLRP3 inflammasome pathway and stimulate insulin resistance, and adipocyte-specific Hif1a knockout can ameliorate homocysteine-induced insulin resistance in mice.	Homocysteine	233-245	NLR family, pyrin domain containing 3	Mus musculus	119-124
32432571-8	2020	Further study indicated that Sal alleviated PD through inhibiting NLRP3-dependent pyroptosis.	rhodioloside	29-32	NLR family, pyrin domain containing 3	Mus musculus	66-71
32432571-9	2020	In conclusion, pyroptosis plays a key role in PD and Sal protects dopaminergic neurons by inhibiting NLRP3-dependent pyroptosis through: (1) indirectly reducing the production of NLRP3, pro-IL-1beta and pro-IL-18 by inhibiting TLR4/MyD88/NF-kappaB signaling pathways, (2) directly suppressing pyroptosis through inhibiting TXNIP/NLRP3/caspase-1 signaling pathways.	rhodioloside	53-56	NLR family, pyrin domain containing 3	Mus musculus	101-106
32432571-9	2020	In conclusion, pyroptosis plays a key role in PD and Sal protects dopaminergic neurons by inhibiting NLRP3-dependent pyroptosis through: (1) indirectly reducing the production of NLRP3, pro-IL-1beta and pro-IL-18 by inhibiting TLR4/MyD88/NF-kappaB signaling pathways, (2) directly suppressing pyroptosis through inhibiting TXNIP/NLRP3/caspase-1 signaling pathways.	rhodioloside	53-56	NLR family, pyrin domain containing 3	Mus musculus	179-184
32432571-9	2020	In conclusion, pyroptosis plays a key role in PD and Sal protects dopaminergic neurons by inhibiting NLRP3-dependent pyroptosis through: (1) indirectly reducing the production of NLRP3, pro-IL-1beta and pro-IL-18 by inhibiting TLR4/MyD88/NF-kappaB signaling pathways, (2) directly suppressing pyroptosis through inhibiting TXNIP/NLRP3/caspase-1 signaling pathways.	rhodioloside	53-56	NLR family, pyrin domain containing 3	Mus musculus	179-184
32508525-3	2020	This study is aimed at investigating the modulation of NLRP3 inflammasome priming by endogenous glucocorticoids (corticosterone, CORT) and its relationship with xanthine oxidase (XO).	Cortisone	129-133	NLR family, pyrin domain containing 3	Mus musculus	55-60
32508525-6	2020	Then, the effect of higher concentrations of CORT (700 ng/ml) on LPS-induced NLRP3 expression and the effect of allopurinol (250 mug/ml) were observed.	Cortisone	45-49	NLR family, pyrin domain containing 3	Mus musculus	77-82
32508525-9	2020	The results showed that LPS-induced NLRP3 expression was upregulated further by pretreatment with CORT (300 ng/ml) (P < 0.05); however, higher concentrations of CORT (greater than 700 ng/ml) downregulated NLRP3 expression (P < 0.01) and the expression and activity of XO (P < 0.05 and P < 0.01, respectively).	Cortisone	98-102	NLR family, pyrin domain containing 3	Mus musculus	36-41
32508525-9	2020	The results showed that LPS-induced NLRP3 expression was upregulated further by pretreatment with CORT (300 ng/ml) (P < 0.05); however, higher concentrations of CORT (greater than 700 ng/ml) downregulated NLRP3 expression (P < 0.01) and the expression and activity of XO (P < 0.05 and P < 0.01, respectively).	Cortisone	98-102	NLR family, pyrin domain containing 3	Mus musculus	205-210
32508525-9	2020	The results showed that LPS-induced NLRP3 expression was upregulated further by pretreatment with CORT (300 ng/ml) (P < 0.05); however, higher concentrations of CORT (greater than 700 ng/ml) downregulated NLRP3 expression (P < 0.01) and the expression and activity of XO (P < 0.05 and P < 0.01, respectively).	Cortisone	161-165	NLR family, pyrin domain containing 3	Mus musculus	36-41
32508525-10	2020	Allopurinol significantly inhibited NLRP3 expression.	Allopurinol	0-11	NLR family, pyrin domain containing 3	Mus musculus	36-41
32508525-11	2020	However, XO expression and activity, NLRP3 expression, and supernatant IL-1beta and IL-18 levels were significantly increased in the RU486 group compared with the CORT group.	Mifepristone	133-138	NLR family, pyrin domain containing 3	Mus musculus	37-42
32508525-12	2020	In conclusion, our results suggested that CORT inhibits LPS-induced NLRP3 inflammasome priming in macrophages.	Cortisone	42-46	NLR family, pyrin domain containing 3	Mus musculus	68-73
32432571-0	2020	Salidroside ameliorates Parkinson"s disease by inhibiting NLRP3-dependent pyroptosis.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	58-63
32508525-0	2020	Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase.	Corticosterone	0-14	NLR family, pyrin domain containing 3	Mus musculus	36-41
32508525-3	2020	This study is aimed at investigating the modulation of NLRP3 inflammasome priming by endogenous glucocorticoids (corticosterone, CORT) and its relationship with xanthine oxidase (XO).	Corticosterone	113-127	NLR family, pyrin domain containing 3	Mus musculus	55-60
32454788-0	2020	Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis.	Arginine	12-20	NLR family, pyrin domain containing 3	Mus musculus	50-55
32454788-4	2020	This study investigated the effect of intravenous Arg supplementation on modulating NLRP3 inflammasome activity in relation to septic AKI.	Arginine	50-53	NLR family, pyrin domain containing 3	Mus musculus	84-89
32454788-12	2020	After Arg treatment, plasma Arg and NO levels increased, kidney function improved, and expressions of renal NLRP3 inflammasome-related proteins were downregulated.	Arginine	6-9	NLR family, pyrin domain containing 3	Mus musculus	108-113
32454788-13	2020	Changes in plasma NO and renal NLRP3 inflammasome-related protein expression were abrogated when L-NIL was given to the Arg sepsis groups.	Arginine	120-123	NLR family, pyrin domain containing 3	Mus musculus	31-36
32454788-15	2020	The findings suggest that intravenous Arg supplementation immediately after sepsis restores plasma Arg levels and is beneficial for attenuating septic AKI, partly via NO-mediated NLRP3 inflammasome inhibition.	Arginine	38-41	NLR family, pyrin domain containing 3	Mus musculus	179-184
32440120-0	2020	The NLRP3-Mediated Neuroinflammatory Responses to CdTe Quantum Dots and the Protection of ZnS Shell.	cadmium telluride	50-54	NLR family, pyrin domain containing 3	Mus musculus	4-9
32435622-7	2020	CAPE regulated NLRP3 at the post-transcriptional level by inhibiting reactive oxygen species (ROS) production.	caffeic acid phenethyl ester	0-4	NLR family, pyrin domain containing 3	Mus musculus	15-20
32419986-0	2020	Tetrandrine alleviates cerebral ischemia/reperfusion injury by suppressing NLRP3 inflammasome activation via Sirt-1.	tetrandrine	0-11	NLR family, pyrin domain containing 3	Mus musculus	75-80
32419986-4	2020	Therefore, the aim of this study was to investigate the possible effects of Tet on cerebral ischemia and the related mechanisms involved in NLRP3 inflammasome.	tetrandrine	76-79	NLR family, pyrin domain containing 3	Mus musculus	140-145
32419986-12	2020	Conclusion: Our results demonstrate that Tet has benefits for cerebral I/R injury, which are partially related to the suppression of NLRP3 inflammasome activation via upregulating Sirt-1.	tetrandrine	41-44	NLR family, pyrin domain containing 3	Mus musculus	133-138
32440120-0	2020	The NLRP3-Mediated Neuroinflammatory Responses to CdTe Quantum Dots and the Protection of ZnS Shell.	Zinc	90-93	NLR family, pyrin domain containing 3	Mus musculus	4-9
32435622-7	2020	CAPE regulated NLRP3 at the post-transcriptional level by inhibiting reactive oxygen species (ROS) production.	Reactive Oxygen Species	69-92	NLR family, pyrin domain containing 3	Mus musculus	15-20
32435622-7	2020	CAPE regulated NLRP3 at the post-transcriptional level by inhibiting reactive oxygen species (ROS) production.	Reactive Oxygen Species	94-97	NLR family, pyrin domain containing 3	Mus musculus	15-20
32440120-5	2020	When investigating the mechanisms of cadmium-containing QDs causing IL-1ss-mediated inflammation, the findings suggested that cadmium-containing QDs activated the NLRP3 inflammasome by causing excessive ROS generation, and resulted in IL-1ss release.	Cadmium	37-44	NLR family, pyrin domain containing 3	Mus musculus	163-168
32435622-8	2020	However, CAPE did not affect NLRP3 or IL-1beta transcription, but instead enhanced NLRP3 binding to ubiquitin molecules, promoting NLRP3 ubiquitination, and contributing to the anti-tumor effect in the AOM/DSS mouse model.	caffeic acid phenethyl ester	9-13	NLR family, pyrin domain containing 3	Mus musculus	83-88
32435622-8	2020	However, CAPE did not affect NLRP3 or IL-1beta transcription, but instead enhanced NLRP3 binding to ubiquitin molecules, promoting NLRP3 ubiquitination, and contributing to the anti-tumor effect in the AOM/DSS mouse model.	caffeic acid phenethyl ester	9-13	NLR family, pyrin domain containing 3	Mus musculus	83-88
32375810-11	2020	Mechanistically, CD11b-mediated NLRP3 inflammasome activation contributes to paraquat and maneb-induced LC/NE neurodegeneration.	Paraquat	77-85	NLR family, pyrin domain containing 3	Mus musculus	32-37
32375810-11	2020	Mechanistically, CD11b-mediated NLRP3 inflammasome activation contributes to paraquat and maneb-induced LC/NE neurodegeneration.	Maneb	90-95	NLR family, pyrin domain containing 3	Mus musculus	32-37
32440120-5	2020	When investigating the mechanisms of cadmium-containing QDs causing IL-1ss-mediated inflammation, the findings suggested that cadmium-containing QDs activated the NLRP3 inflammasome by causing excessive ROS generation, and resulted in IL-1ss release.	Cadmium	126-133	NLR family, pyrin domain containing 3	Mus musculus	163-168
32375810-13	2020	Furthermore, inhibition of NLRP3 inflammasome by glybenclamide, a sulfonylurea inhibitor of NLRP3 inflammasome, was found to be able to suppress microglial proinflammatory activation and nuclear factor-kappaB activation induced by paraquat and maneb.	Glyburide	49-62	NLR family, pyrin domain containing 3	Mus musculus	27-32
32435622-9	2020	Moreover, CAPE suppressed the interaction between NLRP3 and CSN5 but enhanced that between NLRP3 and Cullin1 both in vivo and in vitro.	caffeic acid phenethyl ester	10-14	NLR family, pyrin domain containing 3	Mus musculus	50-55
32440120-5	2020	When investigating the mechanisms of cadmium-containing QDs causing IL-1ss-mediated inflammation, the findings suggested that cadmium-containing QDs activated the NLRP3 inflammasome by causing excessive ROS generation, and resulted in IL-1ss release.	ros	203-206	NLR family, pyrin domain containing 3	Mus musculus	163-168
32435622-9	2020	Moreover, CAPE suppressed the interaction between NLRP3 and CSN5 but enhanced that between NLRP3 and Cullin1 both in vivo and in vitro.	caffeic acid phenethyl ester	10-14	NLR family, pyrin domain containing 3	Mus musculus	91-96
32435622-10	2020	Altogether, our findings demonstrate that CAPE prevents CAC by post-transcriptionally inhibiting NLRP3 inflammasome.	caffeic acid phenethyl ester	42-46	NLR family, pyrin domain containing 3	Mus musculus	97-102
32375810-13	2020	Furthermore, inhibition of NLRP3 inflammasome by glybenclamide, a sulfonylurea inhibitor of NLRP3 inflammasome, was found to be able to suppress microglial proinflammatory activation and nuclear factor-kappaB activation induced by paraquat and maneb.	Glyburide	49-62	NLR family, pyrin domain containing 3	Mus musculus	92-97
32375810-13	2020	Furthermore, inhibition of NLRP3 inflammasome by glybenclamide, a sulfonylurea inhibitor of NLRP3 inflammasome, was found to be able to suppress microglial proinflammatory activation and nuclear factor-kappaB activation induced by paraquat and maneb.	Paraquat	231-239	NLR family, pyrin domain containing 3	Mus musculus	27-32
32182125-8	2020	The activity of NOD-like receptor protein 3 (NLRP3) inflammasome was increased when testosterone supplementation was provided.	Testosterone	84-96	NLR family, pyrin domain containing 3	Mus musculus	45-50
32375810-13	2020	Furthermore, inhibition of NLRP3 inflammasome by glybenclamide, a sulfonylurea inhibitor of NLRP3 inflammasome, was found to be able to suppress microglial proinflammatory activation and nuclear factor-kappaB activation induced by paraquat and maneb.	Maneb	244-249	NLR family, pyrin domain containing 3	Mus musculus	27-32
32014690-10	2020	Our data suggest that bronchial epithelial pyroptosis exacerbates airway inflammation and hyper-responsiveness in TDI-induced asthma via NLRP3 inflammasome activation and GSDND cleavage.	Toluene 2,4-Diisocyanate	114-117	NLR family, pyrin domain containing 3	Mus musculus	137-142
32182125-9	2020	However, the enhanced inflammatory response and fibrosis due to testosterone supplementation were negated by inhibiting the activation of NLRP3 using the specific small molecule inhibitor MCC950.	Testosterone	64-76	NLR family, pyrin domain containing 3	Mus musculus	138-143
32182125-9	2020	However, the enhanced inflammatory response and fibrosis due to testosterone supplementation were negated by inhibiting the activation of NLRP3 using the specific small molecule inhibitor MCC950.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	188-194	NLR family, pyrin domain containing 3	Mus musculus	138-143
32182125-10	2020	It suggests that testosterone is a key factor that influences liver injury by regulating NLRP3 inflammasome activation mediated inflammatory response.	Testosterone	17-29	NLR family, pyrin domain containing 3	Mus musculus	89-94
32182125-8	2020	The activity of NOD-like receptor protein 3 (NLRP3) inflammasome was increased when testosterone supplementation was provided.	Testosterone	84-96	NLR family, pyrin domain containing 3	Mus musculus	16-43
32014690-11	2020	Therefore, NLRP3 inflammasome-mediated pyroptosis may be a potential treatment target for TDI-induced asthma.	Toluene 2,4-Diisocyanate	90-93	NLR family, pyrin domain containing 3	Mus musculus	11-16
31883118-8	2020	Eucalyptol inhibited NLRP3 inflammasome activation and pro-inflammatory cytokine productions induced by MSU in ankle tissues in vivo.	eucalyptol	0-10	NLR family, pyrin domain containing 3	Mus musculus	21-26
31883118-11	2020	The in vivo effects of eucalyptol on ankle edema, mechanical allodynia, NLRP3 inflammasome, IL-1beta and TRPV1 expression were mimicked by treating MSU-injected mice with anti-oxidants.	eucalyptol	23-33	NLR family, pyrin domain containing 3	Mus musculus	72-77
32385145-1	2020	BACKGROUND: We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome.	Fluorouracil	42-56	NLR family, pyrin domain containing 3	Mus musculus	137-142
32040233-2	2020	NLRP3 inflammasome is a key player in APAP-induced inflammation.	Acetaminophen	38-42	NLR family, pyrin domain containing 3	Mus musculus	0-5
32040233-16	2020	APAP markedly activated the NLRP3 inflammasome pathway and consequently increased the production of caspase-1 and IL-1beta.	Acetaminophen	0-4	NLR family, pyrin domain containing 3	Mus musculus	28-33
32040233-17	2020	Interestingly, we found that allicin significantly inhibited NLRP3 inflammasome activation, which resulted in decreased caspase-1 and IL-1beta levels.	allicin	29-36	NLR family, pyrin domain containing 3	Mus musculus	61-66
32052502-1	2020	BACKGROUND: Glutathione S-Transferases Omega Class 1 (GSTO1-1) is a unique member of the GST family regulating cellular redox metabolism and innate immunity through the promotion of LPS/TLR4/NLRP3 signaling in macrophages.	Glutathione	12-23	NLR family, pyrin domain containing 3	Mus musculus	191-196
32052502-1	2020	BACKGROUND: Glutathione S-Transferases Omega Class 1 (GSTO1-1) is a unique member of the GST family regulating cellular redox metabolism and innate immunity through the promotion of LPS/TLR4/NLRP3 signaling in macrophages.	Sulfur	24-25	NLR family, pyrin domain containing 3	Mus musculus	191-196
32374299-0	2020	Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of ER stress and the NLRP3 inflammasome pathway.	Ginsenosides	39-51	NLR family, pyrin domain containing 3	Mus musculus	147-152
32374299-7	2020	Further investigations showed that CK treatments inhibited the NLRP3 inflammasome pathway, as evidenced by the declined expression of TXNIP, NLRP3 inflammasomes, ASC, cleaved caspase-1, and mature IL-1beta in hippocampal tissues.	ginsenoside M1	35-37	NLR family, pyrin domain containing 3	Mus musculus	63-68
32374299-7	2020	Further investigations showed that CK treatments inhibited the NLRP3 inflammasome pathway, as evidenced by the declined expression of TXNIP, NLRP3 inflammasomes, ASC, cleaved caspase-1, and mature IL-1beta in hippocampal tissues.	ginsenoside M1	35-37	NLR family, pyrin domain containing 3	Mus musculus	141-146
32385145-1	2020	BACKGROUND: We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome.	Fluorouracil	58-62	NLR family, pyrin domain containing 3	Mus musculus	137-142
32385145-1	2020	BACKGROUND: We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome.	Leucine	148-155	NLR family, pyrin domain containing 3	Mus musculus	137-142
31900028-3	2020	The present study has been designed to elucidate the role of NADPH oxidase system and/or mitochondrial oxidative stress and its downstream pathway NLRP3 inflammasomes in mouse model of acid aspiration mediated ALI.	NADP	61-66	NLR family, pyrin domain containing 3	Mus musculus	147-152
32156650-0	2020	Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.	Ginsenosides	21-32	NLR family, pyrin domain containing 3	Mus musculus	77-82
32337854-6	2020	However, the cell death response to SiO2 in KC differs by inducing pyroptosis as a result of potassium efflux, caspase 1 activation, NLRP3 inflammasome assembly, IL-1beta release, and cleavage of gasdermin-D.	Silicon Dioxide	36-40	NLR family, pyrin domain containing 3	Mus musculus	133-138
32365944-6	2020	Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3-/- mouse model.	sud-mc	10-16	NLR family, pyrin domain containing 3	Mus musculus	26-74
32232236-4	2020	Fucoxanthin also significantly attenuated the palmitate-induced transcriptional expression of Il-6, Il-1beta, Tnfalpha and Nlrp3 inflammasomes and increased the expression of Tgfb.	fucoxanthin	0-11	NLR family, pyrin domain containing 3	Mus musculus	123-128
32232236-4	2020	Fucoxanthin also significantly attenuated the palmitate-induced transcriptional expression of Il-6, Il-1beta, Tnfalpha and Nlrp3 inflammasomes and increased the expression of Tgfb.	Palmitates	46-55	NLR family, pyrin domain containing 3	Mus musculus	123-128
32365944-6	2020	Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3-/- mouse model.	sud-mc	10-16	NLR family, pyrin domain containing 3	Mus musculus	76-81
32365944-6	2020	Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3-/- mouse model.	sud-mc	10-16	NLR family, pyrin domain containing 3	Mus musculus	150-155
32365944-6	2020	Moreover, SUD-MC actuated NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome-dependent pulmonary inflammation, as confirmed by the NLRP3 inflammasome inhibitor and the NLRP3-/- mouse model.	sud-mc	10-16	NLR family, pyrin domain containing 3	Mus musculus	150-155
32425506-0	2020	Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation.	anisodamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	150-155
32425506-9	2020	In addition, TUNEL analysis showed that ANI-induced apoptosis of tumor cells, and NLRP3 overexpression reversed the inhibitory effect of ANI on HCC.	anisodamine	137-140	NLR family, pyrin domain containing 3	Mus musculus	82-87
32312957-2	2020	Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome-mediated diseases.	carnosol	21-29	NLR family, pyrin domain containing 3	Mus musculus	145-150
32344663-2	2020	A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium (DSS)-induced colitis via its potential antioxidant capacity, and by inhibiting the activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome.	Dimethyl Fumarate	39-56	NLR family, pyrin domain containing 3	Mus musculus	207-255
32344663-2	2020	A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium (DSS)-induced colitis via its potential antioxidant capacity, and by inhibiting the activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome.	Dimethyl Fumarate	39-56	NLR family, pyrin domain containing 3	Mus musculus	257-262
32344663-2	2020	A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium (DSS)-induced colitis via its potential antioxidant capacity, and by inhibiting the activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome.	Dimethyl Fumarate	58-61	NLR family, pyrin domain containing 3	Mus musculus	207-255
32344663-2	2020	A previous study has demonstrated that dimethyl fumarate (DMF) protects mice from dextran sulfate sodium (DSS)-induced colitis via its potential antioxidant capacity, and by inhibiting the activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome.	Dimethyl Fumarate	58-61	NLR family, pyrin domain containing 3	Mus musculus	257-262
32312957-2	2020	Here, we report that carnosol inhibits NLRP3 inflammasome activation by directly targeting heat-shock protein 90 (HSP90), which is essential for NLRP3 inflammasome activity, thereby treating inflammasome-mediated diseases.	carnosol	21-29	NLR family, pyrin domain containing 3	Mus musculus	39-44
32312957-3	2020	Our data demonstrate that carnosol inhibits NLRP3 inflammasome activation in primary mouse bone marrow-derived macrophages (BMDMs), THP-1 cells and human peripheral blood mononuclear cells (hPBMCs).	carnosol	26-34	NLR family, pyrin domain containing 3	Mus musculus	44-49
32312957-5	2020	In vivo, our results show that carnosol has remarkable therapeutic effects in mouse models of NLRP3 inflammasome-mediated diseases, including endotoxemia and nonalcoholic steatohepatitis (NASH).	carnosol	31-39	NLR family, pyrin domain containing 3	Mus musculus	94-99
32316419-4	2020	We searched substances that could inhibit the activation of the NLRP3 inflammasome and identified sweroside as an NLRP3 inhibitor.	sweroside	98-107	NLR family, pyrin domain containing 3	Mus musculus	114-119
32295623-7	2020	Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma.	Leucine	57-64	NLR family, pyrin domain containing 3	Mus musculus	164-200
32295623-7	2020	Mechanistically, the newly identified nucleotide-binding leucine-rich repeat-containing receptor (NLR) family pyrin domain-containing 12 (NLRP12) collaborated with NLR family pyrin domain-containing 3 (NLRP3) and NLR family CARD domain-containing protein 4 (NLRC4) downstream of the CASP8-HIF-1alpha axis, to elicit pyroptotic processes and interleukin-1beta (IL-1beta) maturation through caspase-1 activation, facilitating pyroptosis and neuroinflammation in acute glaucoma.	Leucine	57-64	NLR family, pyrin domain containing 3	Mus musculus	202-207
32316419-0	2020	Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome.	sweroside	0-9	NLR family, pyrin domain containing 3	Mus musculus	82-87
32316419-8	2020	Sweroside effectively inhibited NLRP3 inflammasome activation in primary macrophages as shown by a decrease in IL-1beta and caspase-1 production.	sweroside	0-9	NLR family, pyrin domain containing 3	Mus musculus	32-37
32316419-4	2020	We searched substances that could inhibit the activation of the NLRP3 inflammasome and identified sweroside as an NLRP3 inhibitor.	sweroside	98-107	NLR family, pyrin domain containing 3	Mus musculus	64-69
32316419-10	2020	The improvement of NASH symptoms by sweroside was accompanied with its inhibitory effects on the hepatic NLRP3 inflammasome as hepatic IL-1beta and caspase-1 were decreased.	sweroside	36-45	NLR family, pyrin domain containing 3	Mus musculus	105-110
32126212-0	2020	Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells.	benzyl isothiocyanate	0-21	NLR family, pyrin domain containing 3	Mus musculus	158-163
32126212-0	2020	Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells.	Cholesterol	43-54	NLR family, pyrin domain containing 3	Mus musculus	158-163
32316419-11	2020	Furthermore, sweroside blocked de novo synthesis of mitochondrial DNA in the liver, contributing to suppression of the NLRP3 inflammasome.	sweroside	13-22	NLR family, pyrin domain containing 3	Mus musculus	119-124
32126212-0	2020	Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells.	Cholesterol	128-139	NLR family, pyrin domain containing 3	Mus musculus	158-163
32316419-12	2020	These results suggest that targeting the NLRP3 inflammasome with sweroside could be beneficially employed to improve NASH symptoms.	sweroside	65-74	NLR family, pyrin domain containing 3	Mus musculus	41-46
32268299-8	2020	In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1beta) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice.	Spermidine	97-107	NLR family, pyrin domain containing 3	Mus musculus	61-66
32268299-8	2020	In addition, western blot results (Bcl-2, Bax and Caspase-3, NLRP3, IL-18, IL-1beta) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including NGF, PSD95and PSD93 and BDNF in neurons of SAMP8 mice.	Spermine	112-120	NLR family, pyrin domain containing 3	Mus musculus	61-66
32032741-0	2020	Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.	dimethylaminomylide	34-53	NLR family, pyrin domain containing 3	Mus musculus	113-118
32223388-0	2020	Targeting the NLRP3 Inflammasome With Inhibitor MCC950 Prevents Aortic Aneurysms and Dissections in Mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	48-54	NLR family, pyrin domain containing 3	Mus musculus	14-19
32223388-3	2020	In this study, we tested the effects of MCC950, a potent, selective NLRP3 inhibitor, on preventing aortic destruction and aortic aneurysm and dissection formation.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	40-46	NLR family, pyrin domain containing 3	Mus musculus	68-73
32032741-0	2020	Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.	dimethylaminomicheliolide	55-61	NLR family, pyrin domain containing 3	Mus musculus	113-118
32032741-0	2020	Anti-neuroinflammatory effects of dimethylaminomylide (DMAMCL, i.e., ACT001) are associated with attenuating the NLRP3 inflammasome in MPTP-induced Parkinson disease in mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	135-139	NLR family, pyrin domain containing 3	Mus musculus	113-118
32032741-7	2020	In addition, it alleviates dopaminergic neurodegeneration in the nigrostriatal pathway and inhibits oxidative stress, the inflammatory response and activation of the NLRP3 inflammasome in the midbrain of MPTP-induced PD mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	204-208	NLR family, pyrin domain containing 3	Mus musculus	166-171
32032741-9	2020	Overall, our study showed that ACT001 alleviates NLRP3-mediated neuroinflammation in PD mice induced by MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	104-108	NLR family, pyrin domain containing 3	Mus musculus	49-54
32108526-8	2020	SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3).	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	243-248
32246016-6	2020	Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation.	Reactive Oxygen Species	50-73	NLR family, pyrin domain containing 3	Mus musculus	99-104
32246016-6	2020	Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation.	Reactive Oxygen Species	75-78	NLR family, pyrin domain containing 3	Mus musculus	99-104
32322412-10	2020	PCR and western blot results suggested that the pranoprofen group expressed less NLRP3, IL-1beta, and MMP-13 mRNA and protein expression in corneal tissue than the saline group (p < 0.05).	pyranoprofen	48-59	NLR family, pyrin domain containing 3	Mus musculus	81-86
32322412-11	2020	Conclusion: Pranoprofen may alleviate inflammatory response by inhibiting the expression levels of NLRP3 and IL-1beta at the early stage of corneal alkali injury, lowering the expression of MMP-13 and ultimately reducing corneal epithelial damage.	pyranoprofen	12-23	NLR family, pyrin domain containing 3	Mus musculus	99-104
32108526-8	2020	SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3).	suhx	14-18	NLR family, pyrin domain containing 3	Mus musculus	243-248
32108526-11	2020	Thus, SuHx-induced RV and pulmonary dysfunction, inflammation, and fibrosis can be attenuated or prevented by SFN, supporting the rationale for further studies to investigate SFN and the role of Nrf2 and NLRP3 pathways in preclinical and clinical PAH studies.NEW & NOTEWORTHY Pulmonary arterial hypertension (PAH) in this murine model (SU5416 + hypoxia) is associated with early changes in right ventricular (RV) diastolic and systolic function.	suhx	6-10	NLR family, pyrin domain containing 3	Mus musculus	204-209
31758699-0	2020	Naringenin attenuates nonalocholic fatty liver disease by downregulating NLRP3/NF-kappaB pathway in mice.	naringenin	0-10	NLR family, pyrin domain containing 3	Mus musculus	73-78
31758699-8	2020	In KCs isolated from WT mice, NGN could inhibit NLRP3 expression.	naringenin	30-33	NLR family, pyrin domain containing 3	Mus musculus	48-53
31758699-9	2020	Besides, NGN also inhibited lipid deposition, NLRP3 and IL-1beta expression in WT hepatocytes, but lost efficacy in NLRP3-/- hepatocytes.	naringenin	9-12	NLR family, pyrin domain containing 3	Mus musculus	46-51
31758699-10	2020	After re-expressing NLRP3 in NLRP3-/- hepatocytes by adenovirus, the anti-lipid deposition effect of NGN was restored.	naringenin	101-104	NLR family, pyrin domain containing 3	Mus musculus	20-25
31758699-10	2020	After re-expressing NLRP3 in NLRP3-/- hepatocytes by adenovirus, the anti-lipid deposition effect of NGN was restored.	naringenin	101-104	NLR family, pyrin domain containing 3	Mus musculus	29-34
31758699-11	2020	CONCLUSION AND IMPLICATIONS: Our results elucidated that NGN prevented NAFLD via downregulating NLRP3/NF-kappaB signaling pathway both in KCs and hepatocytes, thus attenuating inflammation in the mice livers.	naringenin	57-60	NLR family, pyrin domain containing 3	Mus musculus	96-101
32043638-3	2020	Dietary administration of TMOP alleviated hyperuricemia and renal inflammation phenotypes, reprogramed uric acid metabolism pathways, inhibited the activation of NLRP3 inflammasome and TLR4/MyD88/NF-kappaB signaling pathways, and suppressed the phosphorylation of p65-NF-kappaB.	tmop	26-30	NLR family, pyrin domain containing 3	Mus musculus	162-167
32067273-7	2020	Our findings indicate that melatonin produces an antifibrotic effect via inhibiting lncR-MALAT1/miR-141-mediated NLRP3 inflammasome activation and TGF-beta1/Smads signaling, and it might be considered a potential agent for the treatment of DCM.	Melatonin	27-36	NLR family, pyrin domain containing 3	Mus musculus	113-118
31916051-0	2020	Isofraxidin Alleviates Myocardial Infarction Through NLRP3 Inflammasome Inhibition.	isofraxidin	0-11	NLR family, pyrin domain containing 3	Mus musculus	53-58
32086866-6	2020	Moreover, 5-BDBD attenuated ATPgammaS induced NLRP3 inflammasome induction in renal proximal tubules from WT mice.	5-(3-bromophenyl)-1,3-dihydro-2H-benzofuro(3,2-e)-1,4-diazepin-2-one	10-16	NLR family, pyrin domain containing 3	Mus musculus	46-51
32086866-6	2020	Moreover, 5-BDBD attenuated ATPgammaS induced NLRP3 inflammasome induction in renal proximal tubules from WT mice.	adenosine 5'-O-(3-thiotriphosphate)	28-37	NLR family, pyrin domain containing 3	Mus musculus	46-51
32067273-0	2020	Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-beta1/Smads signaling in diabetic cardiomyopathy.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	84-89
32067273-2	2020	Herein, we found that melatonin administration significantly ameliorated cardiac dysfunction and reduced collagen production by inhibiting TGF-beta1/Smads signaling and NLRP3 inflammasome activation, as manifested by downregulating the expression of TGF-beta1, p-Smad2, p-Smad3, NLRP3, ASC, cleaved caspase-1, mature IL-1beta, and IL-18 in the heart of melatonin-treated mice with diabetes mellitus (DM).	Melatonin	22-31	NLR family, pyrin domain containing 3	Mus musculus	169-174
32067273-2	2020	Herein, we found that melatonin administration significantly ameliorated cardiac dysfunction and reduced collagen production by inhibiting TGF-beta1/Smads signaling and NLRP3 inflammasome activation, as manifested by downregulating the expression of TGF-beta1, p-Smad2, p-Smad3, NLRP3, ASC, cleaved caspase-1, mature IL-1beta, and IL-18 in the heart of melatonin-treated mice with diabetes mellitus (DM).	Melatonin	22-31	NLR family, pyrin domain containing 3	Mus musculus	279-284
32116027-5	2020	It was observed that calycosin repressed oxidative stress by enhancing Nrf2 anti-oxidative pathway and suppressed inflammation by blocking NACHT, NALP3 inflammasome and NF-kappaB pathway activation.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	NLR family, pyrin domain containing 3	Mus musculus	146-151
31552548-0	2020	Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-kappaB pathway in mice.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	119-124
31552548-2	2020	Because oridonin (Ori) has been indicated as a covalent NLRP3 inhibitor with strong anti-inflammasome activity, we herein aimed to assess the effects of Ori in a mouse model of carrageenan (CAR)-induced pleurisy.	oridonin	8-16	NLR family, pyrin domain containing 3	Mus musculus	56-61
31552548-5	2020	Regarding cellular pathways, Ori could alleviate the CAR-activated NF-kappaB and TXNIP/NLRP3 pathways.	oridonin	29-32	NLR family, pyrin domain containing 3	Mus musculus	87-92
31552548-9	2020	In conclusion, Ori conferred protection against CAR-induced pleurisy via Nrf2-dependent antioxidative and NLRP3-dependent anti-inflammatory properties.	oridonin	15-18	NLR family, pyrin domain containing 3	Mus musculus	106-111
31916051-12	2020	Taken together, we initially reported the cardio-protective and alleviative effect of isofraxidin on MI and uncovered its underlying mechanism related to the NLRP3 inflammasome inhibition.	isofraxidin	86-97	NLR family, pyrin domain containing 3	Mus musculus	158-163
32044659-0	2020	NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-kappaB.	NecroX-5	0-8	NLR family, pyrin domain containing 3	Mus musculus	102-107
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	tubastatin A	9-12	NLR family, pyrin domain containing 3	Mus musculus	38-43
32044659-6	2020	Furthermore, NecroX-5 suppressed the activation of NLRP3 inflammasome and NF-kappaB signalpathway.	NecroX-5	13-21	NLR family, pyrin domain containing 3	Mus musculus	51-56
32062071-0	2020	Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation.	glaucocalyxin A	0-15	NLR family, pyrin domain containing 3	Mus musculus	85-90
32062073-6	2020	Furthermore, OVA challenge elevated the activation of NLRP3 inflammasome with higher protein expression of NLRP3, caspase1 and IL-1beta, enhanced oxidative stress with higher expression of 8-OHdG, nitrotyrosine and SOD2, increased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	8-ohdg	189-195	NLR family, pyrin domain containing 3	Mus musculus	54-59
32062073-6	2020	Furthermore, OVA challenge elevated the activation of NLRP3 inflammasome with higher protein expression of NLRP3, caspase1 and IL-1beta, enhanced oxidative stress with higher expression of 8-OHdG, nitrotyrosine and SOD2, increased the expression of mitochondrial fusion/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin-related protein 1 (DRP1) and Fission 1 (Fis1).	Nitrotyrosine	197-210	NLR family, pyrin domain containing 3	Mus musculus	54-59
31982515-3	2020	Addition of the membrane-permeant zinc chelator TPEN blocked the increases in the levels of NLRP3 and caspase-1 as well as the release of inflammatory cytokines, indicating a role for increased zinc in LPS-induced inflammasome formation.	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	48-52	NLR family, pyrin domain containing 3	Mus musculus	92-97
32087352-0	2020	Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation.	silica dioxide	0-14	NLR family, pyrin domain containing 3	Mus musculus	91-96
31939051-1	2020	We found that circadian changes in ATP level in peripheral blood (PB) activate the Nlrp3 inflammasome, which triggers diurnal release of hematopoietic stem/progenitor cells (HSPCs) from murine bone marrow (BM) into PB.	Adenosine Triphosphate	35-38	NLR family, pyrin domain containing 3	Mus musculus	83-88
31939051-2	2020	Consistent with this finding, we observed circadian changes in expression of mRNA for Nlrp3 inflammasome-related genes, including Nlrp3, caspase 1, IL-1beta, IL-18, gasdermin (GSDMD), HMGB1, and S100A9.	GSDMC protein, human	165-174	NLR family, pyrin domain containing 3	Mus musculus	86-91
31939051-3	2020	Circadian release of HSPCs from BM into PB as well as expression of Nlrp3-associated genes was decreased in mice in which pannexin 1-mediated secretion of ATP was inhibited by the blocking peptide 10Panx and in animals exposed to the specific small-molecule inhibitor of the Nlrp3 inflammasome MCC950.	Adenosine Triphosphate	155-158	NLR family, pyrin domain containing 3	Mus musculus	68-73
31939051-3	2020	Circadian release of HSPCs from BM into PB as well as expression of Nlrp3-associated genes was decreased in mice in which pannexin 1-mediated secretion of ATP was inhibited by the blocking peptide 10Panx and in animals exposed to the specific small-molecule inhibitor of the Nlrp3 inflammasome MCC950.	Adenosine Triphosphate	155-158	NLR family, pyrin domain containing 3	Mus musculus	275-280
32296329-0	2020	Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis.	calcipotriene	0-12	NLR family, pyrin domain containing 3	Mus musculus	22-27
32296329-11	2020	In addition, VDR agonist calcipotriol exert inhibitory effect on NLRP3 inflammasome activation through activating yes-associated protein 1 (YAP1).	calcipotriene	25-37	NLR family, pyrin domain containing 3	Mus musculus	65-70
32296329-12	2020	In conclusion, our findings proved that calcipotriol suppressed the NLRP3 signal by activating YAP1 to alleviate liver injury and retard fibrogenesis in cholestasis.	calcipotriene	40-52	NLR family, pyrin domain containing 3	Mus musculus	68-73
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	tubastatin A	9-12	NLR family, pyrin domain containing 3	Mus musculus	100-105
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	Oxidopamine	23-29	NLR family, pyrin domain containing 3	Mus musculus	38-43
32296327-4	2020	Results: TBA inhibited 6-OHDA-induced NLRP3 activation, as demonstrated by decreased expressions of NLRP3 and matured caspase-1 and IL-1beta, and also alleviated glial proliferation and dopaminergic neuronal degeneration.	Oxidopamine	23-29	NLR family, pyrin domain containing 3	Mus musculus	100-105
32296327-6	2020	Conclusion: Our findings indicate that pharmacological inhibition of HDAC6 with TBA attenuates NLRP3 inflammation and protects dopaminergic neurons, probably through Prx2 acetylation.	tubastatin A	80-83	NLR family, pyrin domain containing 3	Mus musculus	95-100
32296329-10	2020	Moreover, calcipotriol supplement markedly inhibited NLRP3 inflammasome pathway activation to alleviate liver injury and fibrosis in vivo and inhibit hepatic stellate cell (HSC) activation in vitro.	calcipotriene	10-22	NLR family, pyrin domain containing 3	Mus musculus	53-58
32308747-14	2020	The dual COX-2 and sEH inhibitor PTUPB exerts anti-inflammatory effects in treating ALI by inhibiting the NLRP3 inflammasome activation.	PTUPB	33-38	NLR family, pyrin domain containing 3	Mus musculus	106-111
32308747-0	2020	A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation.	PTUPB	27-32	NLR family, pyrin domain containing 3	Mus musculus	111-116
32269523-11	2020	Finally, the protective effect of Hsp22 cardiac function was almost abolished by overexpression of NLRP3 in DOX-treated mice.	Doxorubicin	108-111	NLR family, pyrin domain containing 3	Mus musculus	99-104
32269523-12	2020	Conclusion: In summary, Hsp22 overexpression in the heart could suppress cardiac injury in response to DOX treatment through blocking TLR4/NLRP3 activation.	Doxorubicin	103-106	NLR family, pyrin domain containing 3	Mus musculus	139-144
32192500-16	2020	CONCLUSIONS: Collectively, these data indicated AOPPs as biomarkers of oxidative stress, modulating inflammatory response in SCI by multiple signaling pathways, which also included the induction of NADPH oxidase dependent ROS, and NLRP3-mediated pyroptosis, and activation of MAPKs and NF-kappaB.	Reactive Oxygen Species	222-225	NLR family, pyrin domain containing 3	Mus musculus	231-236
32308747-11	2020	PTUPB pre-treatment remarkably reduced the activation of macrophages and NLRP3 inflammasome in vitro.	PTUPB	0-5	NLR family, pyrin domain containing 3	Mus musculus	73-78
32214150-13	2020	We conclude that Visfatin/eNampt produces in vivo vascular dysfunction in mice by a Nampt-dependent TLR4-mediated pathway, involving NLRP3-inflammasome and paracrine IL-1beta.	enampt	26-32	NLR family, pyrin domain containing 3	Mus musculus	133-138
31645662-0	2020	Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis.	kanglexin	0-9	NLR family, pyrin domain containing 3	Mus musculus	110-115
32145511-0	2020	Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome.	muscone	0-7	NLR family, pyrin domain containing 3	Mus musculus	152-157
32145511-5	2020	We found that muscone suppressed microglial activation-mediated inflammatory response through the NADPH oxidase 4 (NOX4)/janus kinase 2-signal transducer and activator of transcription 3 (JAK2-STAT3) pathway and pyrin-domain-containing 3 (NLRP3) inflammasome.	muscone	14-21	NLR family, pyrin domain containing 3	Mus musculus	239-244
32145511-7	2020	Furthermore, muscone inhibited the CFA-induced NOX4, p-JAK2/p-STAT3, and NLRP3 inflammasome expression in spinal cord of mice.	muscone	13-20	NLR family, pyrin domain containing 3	Mus musculus	73-78
32145511-8	2020	In conclusion, this study uncovered that muscone relieved inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome.	muscone	41-48	NLR family, pyrin domain containing 3	Mus musculus	193-198
32194416-7	2020	Whereas, the inhibitory effect of BBR on ROS, TXNIP expression, NLRP3 inflammasome activation and pyroptosis could be reversed by H2O2 in AML12 cells.	Hydrogen Peroxide	130-134	NLR family, pyrin domain containing 3	Mus musculus	64-69
32194416-8	2020	This study demonstrates that BBR"s inhibitory effect on NLRP3 inflammasome activation and pyroptosis may be mediated by ROS/TXNIP axis in vitro for the first time.	Reactive Oxygen Species	120-123	NLR family, pyrin domain containing 3	Mus musculus	56-61
31530901-7	2020	Furthermore, PE injection significantly increased the expression of NOD-like receptor protein 3 (NLRP3) and the cleavage of caspase-1 (p20) and interleukin-18 in the heart; similar results were observed in both Langendorff-perfused hearts and cultured cardiomyocytes following the treatment with PE (10 muM).	Phenylephrine	13-15	NLR family, pyrin domain containing 3	Mus musculus	68-95
31530901-7	2020	Furthermore, PE injection significantly increased the expression of NOD-like receptor protein 3 (NLRP3) and the cleavage of caspase-1 (p20) and interleukin-18 in the heart; similar results were observed in both Langendorff-perfused hearts and cultured cardiomyocytes following the treatment with PE (10 muM).	Phenylephrine	13-15	NLR family, pyrin domain containing 3	Mus musculus	97-102
31530901-8	2020	Moreover, PE-induced NLRP3 inflammasome activation and cardiac inflammation was blocked in Nlrp3-/- mice compared with wild-type mice.	Phenylephrine	10-12	NLR family, pyrin domain containing 3	Mus musculus	21-26
31530901-8	2020	Moreover, PE-induced NLRP3 inflammasome activation and cardiac inflammation was blocked in Nlrp3-/- mice compared with wild-type mice.	Phenylephrine	10-12	NLR family, pyrin domain containing 3	Mus musculus	91-96
31973813-0	2020	PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice.	PTUPB	0-5	NLR family, pyrin domain containing 3	Mus musculus	89-94
31973813-8	2020	Additionally, we found that PTUPB reduced the production of pro-inflammatory cytokines and suppressed the NLRP3 inflammasome activation in HFD mice and hepatocytes.	PTUPB	28-33	NLR family, pyrin domain containing 3	Mus musculus	106-111
32184453-4	2020	The nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (NLRP3) inflammasome was more strongly upregulated in colon tissues of Slco2a-/- mice administered DSS and in macrophages isolated from Slco2a1-/- mice than in the WT counterparts.	dss	196-199	NLR family, pyrin domain containing 3	Mus musculus	98-103
31836503-10	2020	Additionally, the P-induced NLRP3 activation in the RAW 264.7 cell line was diminished by the knockdown of Tlr2 or JSH-23 treatment in vitro.	4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine	115-121	NLR family, pyrin domain containing 3	Mus musculus	28-33
33455389-6	2020	However, ROS scavengers could diminish the MoS2 QD-mediated NLRP3 inflammasome activation and pyroptotic cell death in microglia.	Reactive Oxygen Species	9-12	NLR family, pyrin domain containing 3	Mus musculus	60-65
32131850-16	2020	CONCLUSIONS: These findings indicate that Parkin-mediated mitophagy is important for the protective effect of PD in SI-AKI, and the underlying mechanisms include the inhibition of mitochondrial dysfunction and NLRP3 inflammasome activation.	polydatin	110-112	NLR family, pyrin domain containing 3	Mus musculus	210-215
32032542-3	2020	Here, we show that NLRP3, a pattern recognition receptor, is modified by acetylation in macrophages and is deacetylated by SIRT2, an NAD+-dependent deacetylase and a metabolic sensor.	NAD	133-136	NLR family, pyrin domain containing 3	Mus musculus	19-24
32195267-0	2020	MCC950, a Selective Inhibitor of NLRP3 Inflammasome, Reduces the Inflammatory Response and Improves Neurological Outcomes in Mice Model of Spinal Cord Injury.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	33-38
31645662-0	2020	Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis.	Anthraquinones	19-32	NLR family, pyrin domain containing 3	Mus musculus	110-115
31645662-10	2020	We conclude that KLX prevents MI-induced cardiac damages and cardiac dysfunction at least partly through attenuating NLRP3 and subsequent cardiomyocyte pyroptosis, and it is worthy of more rigorous investigations for its potential for alleviating ischemic heart disease.	klx	17-20	NLR family, pyrin domain containing 3	Mus musculus	117-122
32309314-12	2020	While the activation of the NLRP3 pathway was found to be in negative correlation with CHBP treatment.	chbp	87-91	NLR family, pyrin domain containing 3	Mus musculus	28-33
32309314-13	2020	CHBP could suppress the activation of NLRP3 and its downstream inflammatory mediators even with addition of extracellular ATP, a direct activator of the NLRP3 inflammasome.	Adenosine Triphosphate	122-125	NLR family, pyrin domain containing 3	Mus musculus	153-158
32057354-3	2020	Here, we reported that dehydrocostus lactone (DCL), a main component of Saussurea lappa from the traditional Chinese medicine, inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent interleukin (IL)-1beta production in primary mouse macrophages and human peripheral blood mononuclear cells and exerted an inhibitory effect on NLRP3-driven inflammation.	dehydrocostus lactone	23-44	NLR family, pyrin domain containing 3	Mus musculus	137-142
31320730-6	2020	Importantly, we showed that chronic administration of MCC950, a novel selective NLRP3 inhibitor, to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	54-60	NLR family, pyrin domain containing 3	Mus musculus	80-85
32057354-3	2020	Here, we reported that dehydrocostus lactone (DCL), a main component of Saussurea lappa from the traditional Chinese medicine, inhibited NLRP3 inflammasome-mediated caspase-1 activation and subsequent interleukin (IL)-1beta production in primary mouse macrophages and human peripheral blood mononuclear cells and exerted an inhibitory effect on NLRP3-driven inflammation.	dehydrocostus lactone	46-49	NLR family, pyrin domain containing 3	Mus musculus	137-142
32057354-6	2020	These results suggest that DCL is a potent pharmacological inhibitor of NLRP3 inflammasome and may be developed as a therapeutic drug for treating NLRP3-associated diseases.	dehydrocostus lactone	27-30	NLR family, pyrin domain containing 3	Mus musculus	72-77
32057354-6	2020	These results suggest that DCL is a potent pharmacological inhibitor of NLRP3 inflammasome and may be developed as a therapeutic drug for treating NLRP3-associated diseases.	dehydrocostus lactone	27-30	NLR family, pyrin domain containing 3	Mus musculus	147-152
31971317-4	2020	Jmjd3 specific inhibitor GSK J4 or knocking down Jmjd3 significantly inhibited NLRP3 inflammasome activation in lipopolysaccharide (LPS) and nigericin-stimulated bone marrow-derived macrophages.	Nigericin	141-150	NLR family, pyrin domain containing 3	Mus musculus	79-84
31913203-10	2020	fed hyperoxaluric mice 1,3-butanediol, which blocks an inflammatory form of cell death called NLRP3 inflammasome and found less intrarenal oxidative damage and higher anti-inflammatory renal infiltrates in experimentals.	1,3-butylene glycol	23-37	NLR family, pyrin domain containing 3	Mus musculus	94-99
31918161-4	2020	In addition, the Nfkbiz+/- and Nfkbiz-/- mice significantly attenuated serum IL-1beta secretion in response to a monosodium urate injection, a NLRP3 trigger, when compared with Nfkbiz-+/+ mice.	Uric Acid	113-129	NLR family, pyrin domain containing 3	Mus musculus	143-148
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	141-146
31971317-8	2020	Overall, our study reveals that Jmjd3 is a potential epigenetic regulator for the treatment of inflammatory bowel disease (IBD), suggesting that Nrf2 is a potential target gene of Jmjd3 by mediating methylation status of trimethylated H3 lysine 27 (H3K27me3) in the promotor and is required for NLRP3 inflammasome activation, thereby providing the platform for potential future therapeutic interventions in IBD.	tyrosyl-lysine	238-244	NLR family, pyrin domain containing 3	Mus musculus	295-300
32141447-0	2020	Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-kappaB and NLRP3 pathways in carrageenan-induced pleurisy.	Carrageenan	159-170	NLR family, pyrin domain containing 3	Mus musculus	141-146
31986326-0	2020	5-O-methyldihydroquercetin and cilicicone B isolated from Spina Gleditsiae ameliorate lipopolysaccharide-induced acute kidney injury in mice by inhibiting inflammation and oxidative stress via the TLR4/MyD88/TRIF/NLRP3 signaling pathway.	5-O-methyldihydroquercetin	0-26	NLR family, pyrin domain containing 3	Mus musculus	213-218
31986326-0	2020	5-O-methyldihydroquercetin and cilicicone B isolated from Spina Gleditsiae ameliorate lipopolysaccharide-induced acute kidney injury in mice by inhibiting inflammation and oxidative stress via the TLR4/MyD88/TRIF/NLRP3 signaling pathway.	Cilicicone b	31-43	NLR family, pyrin domain containing 3	Mus musculus	213-218
31978804-10	2020	Furthermore, treatment with BAY11-7082, an inhibitor of NF-kappaB, repressed the activation of NF-kappaB, and attenuated LPS induced elevation of NLRP3 and cell death in cardiomyocytes.	3-(4-methylphenylsulfonyl)-2-propenenitrile	28-38	NLR family, pyrin domain containing 3	Mus musculus	146-151
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	NLR family, pyrin domain containing 3	Mus musculus	98-125
31840571-8	2020	It further demonstrates that 2B viroporin activates NLRP3 inflammasome and induces IL-1beta in mice, which enhances the specific immune response against FMDV as an ideal self-adjuvant for FMD VLPs vaccine in guinea pigs.	2,5-dichloro-4-bromophenol	29-41	NLR family, pyrin domain containing 3	Mus musculus	52-57
31978803-5	2020	6-Gingerol administration also inhibited the expression of pyroptosis-related proteins, including NOD-like receptor protein 3 (NLRP3), IL-1beta, and caspase-1.	gingerol	0-10	NLR family, pyrin domain containing 3	Mus musculus	127-132
31860763-0	2020	Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury by suppressing the inflammatory COX-2/NLRP3/NF-kappaB pathway in mice.	eriodictyol	0-11	NLR family, pyrin domain containing 3	Mus musculus	107-112
31860763-5	2020	Moreover, eriodictyol inhibited the COX-2/NLRP3/NF-kappaB signaling pathway in the lung tissues of ALI mice.	eriodictyol	10-21	NLR family, pyrin domain containing 3	Mus musculus	42-47
31860763-6	2020	In conclusion, our observations validated that eriodictyol processed the protective effects on ALI mice, which was related to the regulation of the COX-2/NLRP3/NF-kappaB signaling pathway.	eriodictyol	47-58	NLR family, pyrin domain containing 3	Mus musculus	154-159
32000299-0	2020	Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	61-66
32000299-4	2020	In this study, we used the db/db mice (diabetic model) to discover whether quercetin could improve DE through the Sirtuin1/NLRP3 (NOD-, LRR- and pyrin domain-containing 3) pathway.	Quercetin	75-84	NLR family, pyrin domain containing 3	Mus musculus	123-128
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	89-94
32000299-8	2020	Quercetin also increased the protein expression of SIRT1 and decreased the expression of NLRP3 inflammation-related proteins, including NLRP3, the adaptor protein ASC and cleaved Caspase-1, the pro-inflammatory cytokines IL-1beta and IL-18.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	136-141
32000299-9	2020	In conclusion, the present results indicate that the SIRT1/NLRP3 pathway may be a crucial mechanism for the neuroprotective effect of quercetin against DE.	Quercetin	134-143	NLR family, pyrin domain containing 3	Mus musculus	59-64
31840571-12	2020	This study demonstrates the functions of FMDV RNA and 2B viroporin activate NLRP3 inflammasome and provides some useful information for the development of FMD vaccine self-adjuvant, which is also helpful for the establishment of effective prevention strategies by targeting NLRP3 inflammasome.	2,5-dichloro-4-bromophenol	54-66	NLR family, pyrin domain containing 3	Mus musculus	76-81
31840571-12	2020	This study demonstrates the functions of FMDV RNA and 2B viroporin activate NLRP3 inflammasome and provides some useful information for the development of FMD vaccine self-adjuvant, which is also helpful for the establishment of effective prevention strategies by targeting NLRP3 inflammasome.	2,5-dichloro-4-bromophenol	54-66	NLR family, pyrin domain containing 3	Mus musculus	274-279
32014472-0	2020	NLRP3 inflammasome inhibition attenuates subacute neurotoxicity induced by acrylamide in vitro and in vivo.	Acrylamide	75-85	NLR family, pyrin domain containing 3	Mus musculus	0-5
32114413-0	2020	Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and NLRP3 inflammasome activation in SAMP8 mice.	Ginsenosides	0-11	NLR family, pyrin domain containing 3	Mus musculus	91-96
32116706-9	2020	The expression of NLRP3, active caspase-1, and active caspase-3 enhanced by PM were also downregulated by hydrogen sulfide in mice lung.	Hydrogen Sulfide	106-122	NLR family, pyrin domain containing 3	Mus musculus	18-23
32292543-0	2020	Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors.	n-cyano-sulfoximineurea	13-36	NLR family, pyrin domain containing 3	Mus musculus	83-88
32292543-2	2020	In this study, rationally designed mimics of sulfonylurea moiety were investigated as NLRP3 inhibitors.	Sulfonylurea Compounds	45-57	NLR family, pyrin domain containing 3	Mus musculus	86-91
32292543-3	2020	Our results culminated into discovery of series of unprecedented N-cyano sulfoximineurea derivatives as potent NLRP3 inflammasome inhibitors.	n-cyano sulfoximineurea	65-88	NLR family, pyrin domain containing 3	Mus musculus	111-116
32096759-5	2020	Moreover, independent of this activity, Trx1 is critical for NLRP3 inflammasome activation and IL-1b production in macrophages by detoxifying excessive ROS levels.	ros	152-155	NLR family, pyrin domain containing 3	Mus musculus	61-66
32110933-0	2020	Glycine Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Regulating NLRP3 Inflammasome and NRF2 Signaling.	Glycine	0-7	NLR family, pyrin domain containing 3	Mus musculus	78-83
32110933-6	2020	Further study showed that glycine-reduced LPS challenge resulted in the upregulation of nuclear factor kappaB (NF-kappaB), nucleotide binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome.	Glycine	26-33	NLR family, pyrin domain containing 3	Mus musculus	180-185
32110933-8	2020	Our findings indicated that glycine pretreatment prevented LPS-induced lung injury by regulating both NLRP3 inflammasome and NRF2 signaling.	Glycine	28-35	NLR family, pyrin domain containing 3	Mus musculus	102-107
32087497-6	2020	For interventional studies, mice received NLRP3 specific inhibitor MCC950 (10 mg/kg) or the vehicle only intraperitoneally.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	67-73	NLR family, pyrin domain containing 3	Mus musculus	42-47
32085388-0	2020	Coixol Suppresses NF-kappaB, MAPK Pathways and NLRP3 Inflammasome Activation in Lipopolysaccharide-Induced RAW 264.7 Cells.	6-methoxybenzoxazolinone	0-6	NLR family, pyrin domain containing 3	Mus musculus	47-52
32085388-3	2020	Furthermore, we found that coixol inhibits mitogen-activated protein kinases (MAPKs), nuclear transcription factor kappa B (NF-kappaB) pathways, and NOD-like receptor protein (NLRP) 3 inflammasome activation.	6-methoxybenzoxazolinone	27-33	NLR family, pyrin domain containing 3	Mus musculus	149-183
32069862-3	2020	Recently, suppression of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome, was shown to alleviate the severity of GalN/LPS-induced liver damage in mice.	Galactosamine	188-192	NLR family, pyrin domain containing 3	Mus musculus	59-126
32069862-3	2020	Recently, suppression of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome, was shown to alleviate the severity of GalN/LPS-induced liver damage in mice.	Galactosamine	188-192	NLR family, pyrin domain containing 3	Mus musculus	128-133
32116706-10	2020	The protective effect of hydrogen sulfide on emphysema, airway inflammation, inhibiting oxidative stress, NLRP3 inflammasome formation, and anti-apoptosis was inhibited by Nrf2 knockout in mice.	Hydrogen Sulfide	25-41	NLR family, pyrin domain containing 3	Mus musculus	106-111
32116706-11	2020	Similarly, hydrogen sulfide attenuated the secretion of IL-1beta, NLRP3 expression, caspase-1 activation, ASC speck formation, and apoptosis caused by fine particulate matter exposure in A549 cells but not in Nrf2 silenced cells.	Hydrogen Sulfide	11-27	NLR family, pyrin domain containing 3	Mus musculus	66-71
32116706-12	2020	Conclusion: Hydrogen sulfide played a protect role in PM-induced mice emphysema and airway inflammation by inhibiting NLRP3 inflammasome formation and apoptosis via Nrf2-dependent pathway.	Hydrogen Sulfide	12-28	NLR family, pyrin domain containing 3	Mus musculus	118-123
32016690-12	2021	The decreased M1 macrophages and neutrophils infiltration and the remission of the NLRP3/IL-1beta pathway, confirmed the FDG-PET (inflammation) imaging results.	4-fluoro-4-deoxyglucose	121-124	NLR family, pyrin domain containing 3	Mus musculus	83-88
32117301-0	2020	TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation.	Melatonin	5-14	NLR family, pyrin domain containing 3	Mus musculus	57-62
32117301-5	2020	Meanwhile, melatonin biosynthesis was reduced in OVA-challenged WT mice, while such reduction was notably rescued by TLR2 deficiency, suggesting that TLR2-NLRP3-mediated allergic airway inflammation was associated with decreased endogenous melatonin biosynthesis.	Melatonin	11-20	NLR family, pyrin domain containing 3	Mus musculus	155-160
32117301-5	2020	Meanwhile, melatonin biosynthesis was reduced in OVA-challenged WT mice, while such reduction was notably rescued by TLR2 deficiency, suggesting that TLR2-NLRP3-mediated allergic airway inflammation was associated with decreased endogenous melatonin biosynthesis.	Melatonin	240-249	NLR family, pyrin domain containing 3	Mus musculus	155-160
32117301-6	2020	Furthermore, addition of melatonin to OVA-challenged WT mice pronouncedly ameliorated airway inflammation, decreased TLR2 expression and NLRP3 inflammasome activation, further implying that melatonin in turn inhibited airway inflammation via suppressing TLR2-NLRP3 signal.	Melatonin	25-34	NLR family, pyrin domain containing 3	Mus musculus	137-142
32117301-6	2020	Furthermore, addition of melatonin to OVA-challenged WT mice pronouncedly ameliorated airway inflammation, decreased TLR2 expression and NLRP3 inflammasome activation, further implying that melatonin in turn inhibited airway inflammation via suppressing TLR2-NLRP3 signal.	Melatonin	25-34	NLR family, pyrin domain containing 3	Mus musculus	259-264
32117301-6	2020	Furthermore, addition of melatonin to OVA-challenged WT mice pronouncedly ameliorated airway inflammation, decreased TLR2 expression and NLRP3 inflammasome activation, further implying that melatonin in turn inhibited airway inflammation via suppressing TLR2-NLRP3 signal.	Melatonin	190-199	NLR family, pyrin domain containing 3	Mus musculus	137-142
32117301-6	2020	Furthermore, addition of melatonin to OVA-challenged WT mice pronouncedly ameliorated airway inflammation, decreased TLR2 expression and NLRP3 inflammasome activation, further implying that melatonin in turn inhibited airway inflammation via suppressing TLR2-NLRP3 signal.	Melatonin	190-199	NLR family, pyrin domain containing 3	Mus musculus	259-264
32117301-7	2020	Most interestingly, although melatonin receptor antagonist luzindole significantly reduced the protein expressions of ASMT, AANAT and subsequent level of melatonin in OVA-challenged TLR2-/- mice, it exhibited null effect on leukocytes infiltration, Th2-cytokines production and NLRP3 activity.	luzindole	59-68	NLR family, pyrin domain containing 3	Mus musculus	278-283
32117301-8	2020	These results indicate that a TLR2-melatonin feedback loop regulates NLRP3 inflammasome activity in allergic airway inflammation, and melatonin may be a promising therapeutic medicine for airway inflammatory diseases such as asthma.	Melatonin	35-44	NLR family, pyrin domain containing 3	Mus musculus	69-74
31854009-10	2020	Inhibition of NLRP3 inflammasome activation and the inflammasome-IL-1 cascade opens novel insights into the development of new therapies to address alcohol use disorder in an era of targeted and precision medicine.	Ethanol	148-155	NLR family, pyrin domain containing 3	Mus musculus	14-19
31866303-6	2020	Berberine significantly inhibited Bmal1 (-2000/+100 bp)- and Nlrp3 (-1310/+100 bp)-Luc reporter activities, and dose-dependently decreased cellular expressions of both Bmal1 and Nlrp3.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	61-66
31506572-6	2020	We further demonstrated that isosibiricin upregulated the expression of dopamine D1/2 receptors in LPS-treated BV-2 cells, resulting in inhibitory effect on nucleotide binding domain-like receptor protein 3 (NLRP3)/caspase-1 inflammasome pathway.	Isosibiricin	29-41	NLR family, pyrin domain containing 3	Mus musculus	157-206
31506572-6	2020	We further demonstrated that isosibiricin upregulated the expression of dopamine D1/2 receptors in LPS-treated BV-2 cells, resulting in inhibitory effect on nucleotide binding domain-like receptor protein 3 (NLRP3)/caspase-1 inflammasome pathway.	Isosibiricin	29-41	NLR family, pyrin domain containing 3	Mus musculus	208-213
31866303-6	2020	Berberine significantly inhibited Bmal1 (-2000/+100 bp)- and Nlrp3 (-1310/+100 bp)-Luc reporter activities, and dose-dependently decreased cellular expressions of both Bmal1 and Nlrp3.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	178-183
31846625-0	2020	H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.	Deuterium	0-3	NLR family, pyrin domain containing 3	Mus musculus	144-149
31989218-0	2020	Novel complementary antitumour effects of celastrol and metformin by targeting IkappaBkappaB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.	celastrol	42-51	NLR family, pyrin domain containing 3	Mus musculus	108-113
31989218-0	2020	Novel complementary antitumour effects of celastrol and metformin by targeting IkappaBkappaB, apoptosis and NLRP3 inflammasome activation in diethylnitrosamine-induced murine hepatocarcinogenesis.	Metformin	56-65	NLR family, pyrin domain containing 3	Mus musculus	108-113
31989218-11	2020	In conclusion, by inhibiting NLRP3 inflammasome and its prerequisite NFkappaB signalling, simultaneous administration of metformin and celastrol appears to have additive benefits in the treatment of HCC compared to cela monotherapy.	Metformin	121-130	NLR family, pyrin domain containing 3	Mus musculus	29-34
31989218-11	2020	In conclusion, by inhibiting NLRP3 inflammasome and its prerequisite NFkappaB signalling, simultaneous administration of metformin and celastrol appears to have additive benefits in the treatment of HCC compared to cela monotherapy.	celastrol	135-144	NLR family, pyrin domain containing 3	Mus musculus	29-34
31846625-8	2020	NaHS treatment also suppressed NLRP3, NF-kappaB and IL-4/STAT6 activation in the obstructed kidneys.	sodium bisulfide	0-4	NLR family, pyrin domain containing 3	Mus musculus	31-36
31846625-10	2020	H2S suppresses NLRP3 activation and subsequently inactivates NF-kappaB and IL-4/STAT6 signaling, which may contribute to the anti-inflammatory and anti-fibrotic effects of H2S.	Deuterium	0-3	NLR family, pyrin domain containing 3	Mus musculus	15-20
31846625-10	2020	H2S suppresses NLRP3 activation and subsequently inactivates NF-kappaB and IL-4/STAT6 signaling, which may contribute to the anti-inflammatory and anti-fibrotic effects of H2S.	Deuterium	172-175	NLR family, pyrin domain containing 3	Mus musculus	15-20
31926478-9	2020	Together, our data suggested that ghrelin protected against ICH-induced SBI by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway.	Ghrelin	34-41	NLR family, pyrin domain containing 3	Mus musculus	90-95
32010314-0	2020	Tacrolimus reduces atherosclerotic plaque formation in ApoE-/- mice by inhibiting NLRP3 inflammatory corpuscles.	Tacrolimus	0-10	NLR family, pyrin domain containing 3	Mus musculus	82-87
32010314-10	2020	The protein content of NLRP3, ASC, Casp-1, IL-1beta and IL-18 in the aorta in ApoE-/- mice was remarkably increased, and they were inhibited to some extent after tacrolimus intervention.	Tacrolimus	162-172	NLR family, pyrin domain containing 3	Mus musculus	23-28
32010314-11	2020	In conclusion, it is speculated that tacrolimus may reduce the formation of AS through inhibiting ROS in macrophages and activation of NLRP3 inflammatory corpuscles and reducing the release of IL-1beta and IL-18.	Tacrolimus	37-47	NLR family, pyrin domain containing 3	Mus musculus	135-140
31596526-9	2020	Mechanistically, we identified the generation of reactive oxygen species and ATP as key events required for SOD1G93A -mediated NLRP3 activation.	Oxygen	58-64	NLR family, pyrin domain containing 3	Mus musculus	127-132
31596526-9	2020	Mechanistically, we identified the generation of reactive oxygen species and ATP as key events required for SOD1G93A -mediated NLRP3 activation.	Adenosine Triphosphate	77-80	NLR family, pyrin domain containing 3	Mus musculus	127-132
32459025-7	2020	Both DLEs and omega-UFAs led to an almost complete inhibition of the inflammatory histopathology of CIA and this was concomitant with the inhibition of NF-kB and the inhibition of the activation of NLRP3.	dles	5-9	NLR family, pyrin domain containing 3	Mus musculus	198-203
32459025-7	2020	Both DLEs and omega-UFAs led to an almost complete inhibition of the inflammatory histopathology of CIA and this was concomitant with the inhibition of NF-kB and the inhibition of the activation of NLRP3.	omega-ufas	14-24	NLR family, pyrin domain containing 3	Mus musculus	198-203
31830477-0	2020	Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation.	Eicosapentaenoic Acid	0-21	NLR family, pyrin domain containing 3	Mus musculus	103-108
31930778-10	2020	Additionally, AOAA attenuated NLRP3-Caspase1/IL-1beta activation and decreased the release of IL-6 and TNF-alpha pro-inflammatory cytokines and reciprocally increased IL-10 anti-inflammatory cytokine level in both ischaemic myocardium and M1 macrophages.	Aminooxyacetic Acid	14-18	NLR family, pyrin domain containing 3	Mus musculus	30-35
31930778-11	2020	In conclusion, short-term AOAA treatment significantly improves cardiac function in mice with MI by balancing macrophage polarization through modulating macrophage metabolism and inhibiting NLRP3-Caspase1/IL-1beta pathway.	Aminooxyacetic Acid	26-30	NLR family, pyrin domain containing 3	Mus musculus	190-195
31830477-8	2020	RESULT: Here we show that EPA suppresses ACI-induced inflammatory responses through blocking NLRP3 inflammasome activation.	Eicosapentaenoic Acid	26-29	NLR family, pyrin domain containing 3	Mus musculus	93-98
31830477-9	2020	In addition, EPA inhibits NLRP3 inflammasome activation through G protein-coupled receptor 40 (GPR40) and GPR120.	Eicosapentaenoic Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	26-31
31830477-11	2020	CONCLUSION: EPA exerts beneficial effect on ACI-induced inflammation through blocking NLRP3 inflammasome activation by GPR40 and GPR120.	Eicosapentaenoic Acid	12-15	NLR family, pyrin domain containing 3	Mus musculus	86-91
31996485-4	2020	Tamoxifen-inducible Nlrp3 knock-in (Nlrp3A350V/+CreT-KI) mice and WT mice were administered either control chow diet or diet containing the selective ASK1 inhibitor GS-444217 for 6 weeks.	Tamoxifen	0-9	NLR family, pyrin domain containing 3	Mus musculus	20-25
32009974-10	2019	In endothelial cells, dmDNA activated NLRP3 via mitochondrial ROS and Ca2+ influx.	Calcium	70-74	NLR family, pyrin domain containing 3	Mus musculus	38-43
31979265-0	2020	Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome.	auxarconjugatin A	10-37	NLR family, pyrin domain containing 3	Mus musculus	114-119
31979265-2	2020	These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis.	Uric Acid	6-15	NLR family, pyrin domain containing 3	Mus musculus	38-85
31979265-2	2020	These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis.	Uric Acid	6-15	NLR family, pyrin domain containing 3	Mus musculus	87-92
31979265-3	2020	This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo.	polyenylpyrrole	26-41	NLR family, pyrin domain containing 3	Mus musculus	180-185
31979265-3	2020	This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo.	auxarconjugatin A	53-80	NLR family, pyrin domain containing 3	Mus musculus	180-185
31979265-3	2020	This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo.	auxarconjugatin A	82-87	NLR family, pyrin domain containing 3	Mus musculus	180-185
31979265-3	2020	This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo.	Uric Acid	134-143	NLR family, pyrin domain containing 3	Mus musculus	180-185
31979265-6	2020	Additionally, 4-HAB inhibited the NLRP3 inflammasome through Sirt1-dependent autophagy induction.	auxarconjugatin A	14-19	NLR family, pyrin domain containing 3	Mus musculus	34-39
31979265-8	2020	In conclusion, 4-HAB attenuates gouty inflammation, in part by attenuating activation of the NLRP3 inflammasome through the Sirt1/autophagy induction pathway.	auxarconjugatin A	15-20	NLR family, pyrin domain containing 3	Mus musculus	93-98
32023718-18	2020	Conclusions: Sodium butyrate can inhibit the activation of NLRP3 inflammasome and decrease the production of IL-1beta and IL-18 in intestinal mucosa of severe scald mice, which protects the intestinal barrier function by alleviating the alteration of tight junction protein expression and localization.	Butyric Acid	13-28	NLR family, pyrin domain containing 3	Mus musculus	59-64
32023718-14	2020	Compared with those of pure scald group, the protein expressions of NLRP3, IL-1beta, and IL-18 of mice in scald+ sodium butyrate group were significantly decreased (P<0.05).	Butyric Acid	113-128	NLR family, pyrin domain containing 3	Mus musculus	68-73
31703838-6	2020	Podocyte autophagy has been confirmed to be inhibited in high-fat diet/streptozotocin (HFD/STZ)-induced DN mice, and NLRP3 has been found to be upregulated in both mice and human DN biopsies and in vitro.	Streptozocin	91-94	NLR family, pyrin domain containing 3	Mus musculus	117-122
31941010-3	2020	In this study, we further found that the NLRP3 inflammasome was activated in PPVI administrated A549-bearing athymic nude mice.	polyphyllin H	77-81	NLR family, pyrin domain containing 3	Mus musculus	41-46
31805268-0	2020	Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation.	genipin	22-29	NLR family, pyrin domain containing 3	Mus musculus	92-97
31805268-0	2020	Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation.	Ethanol	33-40	NLR family, pyrin domain containing 3	Mus musculus	92-97
31625260-5	2020	Furthermore, old NLRP3 KO mice showed an inhibition of the PI3K/AKT/mTOR pathway and autophagy improvement, compared with old wild mice and preserved Nampt-mediated NAD+ levels with increased SIRT1 protein expression.	NAD	165-168	NLR family, pyrin domain containing 3	Mus musculus	17-22
31738935-0	2020	Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways.	Streptozocin	38-52	NLR family, pyrin domain containing 3	Mus musculus	95-100
31924176-0	2020	Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	54-59
31924176-13	2020	CONCLUSIONS: This study extended our original analysis of the ability of hydrogen to stimulate NLRP3 inflammasome/GSDMD activation in pyroptosis and revealed possible mechanism (s) for improvement of anti-tumor effects in the clinical management of endometrial cancer.	Hydrogen	73-81	NLR family, pyrin domain containing 3	Mus musculus	95-100
33202149-8	2020	As a result, Geniposide could ameliorate inflammatory responses and prevent colitis in DSS-induced acute colitis of mice by activating AMP-activated protein kinase (AMPK)/Transcription 1 (Sirt1) dependent signaling via the suppression of nod-like receptor protein 3 (NLRP3) inflammasome.	geniposide	13-23	NLR family, pyrin domain containing 3	Mus musculus	238-265
33202149-0	2020	Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling.	geniposide	59-69	NLR family, pyrin domain containing 3	Mus musculus	143-148
32345030-7	2020	LPS-induced activation of microglial cells and elevation in expression of inflammatory cytokines including IL-1beta, RANTES, and MCP-1 in the prefrontal cortex of mice were effectively abrogated by muscone, which significantly down-regulated expression of TLR4, MyD88, Caspase-1, NLRP3, renin, and Ang II.	muscone	198-205	NLR family, pyrin domain containing 3	Mus musculus	280-285
33202149-8	2020	As a result, Geniposide could ameliorate inflammatory responses and prevent colitis in DSS-induced acute colitis of mice by activating AMP-activated protein kinase (AMPK)/Transcription 1 (Sirt1) dependent signaling via the suppression of nod-like receptor protein 3 (NLRP3) inflammasome.	geniposide	13-23	NLR family, pyrin domain containing 3	Mus musculus	267-272
33202149-8	2020	As a result, Geniposide could ameliorate inflammatory responses and prevent colitis in DSS-induced acute colitis of mice by activating AMP-activated protein kinase (AMPK)/Transcription 1 (Sirt1) dependent signaling via the suppression of nod-like receptor protein 3 (NLRP3) inflammasome.	Dextran Sulfate	87-90	NLR family, pyrin domain containing 3	Mus musculus	238-265
33202149-8	2020	As a result, Geniposide could ameliorate inflammatory responses and prevent colitis in DSS-induced acute colitis of mice by activating AMP-activated protein kinase (AMPK)/Transcription 1 (Sirt1) dependent signaling via the suppression of nod-like receptor protein 3 (NLRP3) inflammasome.	Dextran Sulfate	87-90	NLR family, pyrin domain containing 3	Mus musculus	267-272
33202149-10	2020	Geniposide suppressed NLRP3 inflammasome and induced AMPK/Sirt1 signaling in LPS-induced BMDM cell or RAW264.7 cell models.	geniposide	0-10	NLR family, pyrin domain containing 3	Mus musculus	22-27
33202149-12	2020	The activation of NLRP3 attenuated the anti-inflammatory effects of geniposide in colitis.	geniposide	68-78	NLR family, pyrin domain containing 3	Mus musculus	18-23
33202149-13	2020	Taken together, our results demonstrated that geniposide ameliorated inflammatory responses in colitis vai the suppression of NLRP3 inflammasome in macrophages by AMPK/Sirt1-dependent signaling.	geniposide	46-56	NLR family, pyrin domain containing 3	Mus musculus	126-131
31664855-4	2020	We found that lack of HO-1 activated lipopolysaccharide (LPS) and ATP-treated bone marrow-derived macrophages, causing an increase in secreted levels of cleaved interleukin (IL)-1B, IL-18, and caspase-1, markers of increased inflammasome activity, whereas HO-1 overexpression suppressed IL-1B, NLRP3, and IL-18.	Adenosine Triphosphate	66-69	NLR family, pyrin domain containing 3	Mus musculus	294-299
31780368-0	2020	Dexamethasone alleviate allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome.	Dexamethasone	0-13	NLR family, pyrin domain containing 3	Mus musculus	93-98
31869665-0	2020	Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-beta structure based virtual screening.	benzo[cd]indol-2-one	13-33	NLR family, pyrin domain containing 3	Mus musculus	91-96
31869665-0	2020	Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-beta structure based virtual screening.	benzylidene-thiazolidine-2,4-dione	38-72	NLR family, pyrin domain containing 3	Mus musculus	91-96
31869665-8	2020	IIIM-1266 and IIIM-1270 displayed bidentate H-bonding with Arg 346 and Glu 305 residues in the active site of ER-beta; and they also strongly occupied the ADP-binding site of NLRP3 protein.	Adenosine Diphosphate	155-158	NLR family, pyrin domain containing 3	Mus musculus	175-180
31882076-0	2020	Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	152-157
31882076-0	2020	Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation.	epigallocatechin gallate	26-52	NLR family, pyrin domain containing 3	Mus musculus	152-157
31882076-0	2020	Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation.	perfluorodecanoic acid	69-91	NLR family, pyrin domain containing 3	Mus musculus	152-157
31882076-6	2020	Moreover, GTPs and EGCG ameliorated hepatic oxidative stress, cell apoptosis, necrosis, steatosis, edema, and degeneration, reduced hepatic inflammation and NLRP3 inflammasome activation caused by a moderate dose of PFDA.	epigallocatechin gallate	19-23	NLR family, pyrin domain containing 3	Mus musculus	157-162
31758498-7	2020	Furthermore, TAF/TDF suppressed the activities of TGFbeta1/Smad3 and NF-kappaB/NLRP3 inflammasome signaling pathways in vivo and in vitro.	tenofovir alafenamide	13-16	NLR family, pyrin domain containing 3	Mus musculus	79-84
31758498-11	2020	CONCLUSIONS: TAF/TDF prevented progression and promoted reversion of liver fibrosis through assembling TGFbeta1/Smad3 and NF-kappaB/NLRP3 inflammasome signaling pathways via upregulating the expression of NS5ATP9.	tenofovir alafenamide	13-16	NLR family, pyrin domain containing 3	Mus musculus	132-137
31813002-0	2020	Ganciclovir reduces irinotecan-induced intestinal toxicity by inhibiting NLRP3 activation.	Ganciclovir	0-11	NLR family, pyrin domain containing 3	Mus musculus	73-78
31813002-0	2020	Ganciclovir reduces irinotecan-induced intestinal toxicity by inhibiting NLRP3 activation.	irinotecan	20-30	NLR family, pyrin domain containing 3	Mus musculus	73-78
31813002-4	2020	Intraperitoneal administration of irinotecan with or without GCV for 4 days induced intestinal toxicity in mice to analyze diarrhea; beta-glucuronidase (beta-GLU) activity; fecal occult blood; hepatic function in blood samples, histopathological changes; and NOD-like receptor 3 (NLRP3), toll-like receptor 4 (TLR4), high-mobility group box 1 protein (HMGB1), phosphorylated nuclear factor kappa B (p-NF-kappaB), occludin, and zonular occludens (ZO-1) expression in colonic and ileal tissues.	irinotecan	34-44	NLR family, pyrin domain containing 3	Mus musculus	259-278
31813002-4	2020	Intraperitoneal administration of irinotecan with or without GCV for 4 days induced intestinal toxicity in mice to analyze diarrhea; beta-glucuronidase (beta-GLU) activity; fecal occult blood; hepatic function in blood samples, histopathological changes; and NOD-like receptor 3 (NLRP3), toll-like receptor 4 (TLR4), high-mobility group box 1 protein (HMGB1), phosphorylated nuclear factor kappa B (p-NF-kappaB), occludin, and zonular occludens (ZO-1) expression in colonic and ileal tissues.	irinotecan	34-44	NLR family, pyrin domain containing 3	Mus musculus	280-285
31957470-0	2020	Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.	empagliflozin	0-13	NLR family, pyrin domain containing 3	Mus musculus	75-80
31957470-0	2020	Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.	empagliflozin	0-13	NLR family, pyrin domain containing 3	Mus musculus	82-131
31957470-4	2020	Of note, empagliflozin attenuated activation of the NLRP3 inflammasome and expression of associated markers of sterile inflammation in hearts from mice with HFrEF, implicating reduced cardiac inflammation as a mechanism of empagliflozin that contributes to sustained function in HFrEF in the absence of diabetes mellitus.	empagliflozin	9-22	NLR family, pyrin domain containing 3	Mus musculus	52-57
31957470-5	2020	In addition, we validate that the beneficial cardiac effects of empagliflozin in HF with preserved ejection fraction (HFpEF; n=9-10) are similarly associated with reduced activation of the NLRP3 inflammasome.	empagliflozin	64-77	NLR family, pyrin domain containing 3	Mus musculus	189-194
31957470-7	2020	CONCLUSIONS: These data provide evidence that the beneficial cardiac effects of empagliflozin are associated with reduced cardiac inflammation via blunting activation of the NLRP3 inflammasome in a Ca2+-dependent manner and hence may be beneficial in treating HF even in the absence of diabetes mellitus.	empagliflozin	80-93	NLR family, pyrin domain containing 3	Mus musculus	174-179
31957470-7	2020	CONCLUSIONS: These data provide evidence that the beneficial cardiac effects of empagliflozin are associated with reduced cardiac inflammation via blunting activation of the NLRP3 inflammasome in a Ca2+-dependent manner and hence may be beneficial in treating HF even in the absence of diabetes mellitus.	Calcium	198-202	NLR family, pyrin domain containing 3	Mus musculus	174-179
31914630-0	2020	Rutaecarpine derivative R3 attenuates atherosclerosis via inhibiting NLRP3 inflammasome-related inflammation and modulating cholesterol transport.	rutecarpine	0-12	NLR family, pyrin domain containing 3	Mus musculus	69-74
31914640-0	2020	Ginsenoside Rg3 suppresses the NLRP3 inflammasome activation through inhibition of its assembly.	ginsenoside Rg3	0-15	NLR family, pyrin domain containing 3	Mus musculus	31-36
31914640-5	2020	Rg3 specifically inhibits activation of NLRP3 but not the NLRC4 or AIM2 inflammasomes.	ginsenoside Rg3	0-3	NLR family, pyrin domain containing 3	Mus musculus	40-45
31914640-7	2020	Mechanistically, Rg3 abrogates NEK7-NLRP3 interaction, and subsequently inhibits NLRP3-ASC interaction, ASC oligomerization, and speckle formation.	ginsenoside Rg3	17-20	NLR family, pyrin domain containing 3	Mus musculus	36-41
31914640-7	2020	Mechanistically, Rg3 abrogates NEK7-NLRP3 interaction, and subsequently inhibits NLRP3-ASC interaction, ASC oligomerization, and speckle formation.	ginsenoside Rg3	17-20	NLR family, pyrin domain containing 3	Mus musculus	81-86
31914640-9	2020	Thus, our findings reveal an anti-inflammatory mechanism for Rg3 and suggest its potential use in NLRP3-driven diseases.	ginsenoside Rg3	61-64	NLR family, pyrin domain containing 3	Mus musculus	98-103
31758498-0	2020	TAF and TDF attenuate liver fibrosis through NS5ATP9, TGFbeta1/Smad3, and NF-kappaB/NLRP3 inflammasome signaling pathways.	tenofovir alafenamide	0-3	NLR family, pyrin domain containing 3	Mus musculus	84-89
31625631-2	2020	In this study, we evaluated the role of hyperglycemic in regulating NLRP3 inflammasome activation by inhibiting autophagy induction in KCs in the TAA-induced liver injury model.	Thioacetamide	146-149	NLR family, pyrin domain containing 3	Mus musculus	68-73
31625631-6	2020	NLRP3 inhibition by its antagonist CY-09 effectively suppressed inflammasome activation in KCs and attenuated liver injury in hyperglycemic mice.	CY5.5 cyanine dye	35-40	NLR family, pyrin domain containing 3	Mus musculus	0-5
31625631-9	2020	AMPK activation by its agonist AICAR or mTOR signaling knockdown by siRNA restored autophagy activation, and subsequently, inhibited NLRP3 inflammasome activation in KCs, leading to ultimately reduced TAA-induced liver injury in the hyperglycemic mice.	Thioacetamide	201-204	NLR family, pyrin domain containing 3	Mus musculus	133-138
31625631-10	2020	Our findings demonstrated that hyperglycemia aggravated TAA-induced acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via inhibiting AMPK/mTOR-mediated autophagy.	Thioacetamide	56-59	NLR family, pyrin domain containing 3	Mus musculus	126-131
31780368-10	2020	DEX also significantly inhibited the activity of NLRP3 inflammasome and reduced the protein contents of Pro-Caspase-1, Caspase-1, Capase-1/Pro-Caspase-1, IL-1beta, IL-6 and IL-17 in lung tissues.	Dexamethasone	0-3	NLR family, pyrin domain containing 3	Mus musculus	49-54
31780368-11	2020	Our study suggested that DEX alleviates allergic airway inflammation by inhibiting the activity of NLRP3 inflammasome and the levels of IL-1beta and IL-18.	Dexamethasone	25-28	NLR family, pyrin domain containing 3	Mus musculus	99-104
32816567-0	2020	Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice.	saikosaponin D	57-71	NLR family, pyrin domain containing 3	Mus musculus	35-40
32694683-2	2020	A widely used ketogenic diet (KD), which is extremely high in fat with very low carbohydrates, drives the host into using beta-hydroxybutyrate for the production of ATP and lowers NLRP3-mediated inflammation.	3-Hydroxybutyric Acid	122-142	NLR family, pyrin domain containing 3	Mus musculus	180-185
32816567-0	2020	Inhibition of oxidative stress and NLRP3 inflammasome by Saikosaponin-d alleviates acute liver injury in carbon tetrachloride-induced hepatitis in mice.	Carbon Tetrachloride	105-125	NLR family, pyrin domain containing 3	Mus musculus	35-40
31141808-0	2020	Prostaglandin E2 Regulates Activation of Mouse Peritoneal Macrophages by Staphylococcus aureus through Toll-Like Receptor 2, Toll-Like Receptor 4, and NLRP3 Inflammasome Signaling.	Dinoprostone	0-16	NLR family, pyrin domain containing 3	Mus musculus	151-156
31141808-7	2020	Our data demonstrate that S. aureus can induce macrophage TLR/mitogen-activated protein kinase/NF-kappaB signaling and that PGE2 treatment upregulates NLRP3/caspase-1 signaling activation.	Dinoprostone	124-128	NLR family, pyrin domain containing 3	Mus musculus	151-156
31141808-8	2020	Thus, macrophage PGE2 secretion after S. aureus infection depends on bacterial lipoprotein maturation and macrophage receptors TLR2, TLR4, and NLRP3.	Dinoprostone	17-21	NLR family, pyrin domain containing 3	Mus musculus	143-148
31141808-9	2020	Moreover, exogenous PGE2 regulates S. aureus-induced macrophage activation through TLRs and NLRP3 inflammasome signaling.	Dinoprostone	20-24	NLR family, pyrin domain containing 3	Mus musculus	92-97
31094238-0	2020	Artemisinin alleviates atherosclerotic lesion by reducing macrophage inflammation via regulation of AMPK/NF-kappaB/NLRP3 inflammasomes pathway.	artemisinin	0-11	NLR family, pyrin domain containing 3	Mus musculus	115-120
31094238-5	2020	Atherosclerotic mice treated with artemisinin showed reduced inflammation by up-regulating adenosine 5"-monophosphate (AMP) activated protein kinase (AMPK) activation and by down-regulating nuclear factor-kappaB (NF-kappaB) phosphorylation and nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome expression in the aortas.	artemisinin	34-45	NLR family, pyrin domain containing 3	Mus musculus	296-301
31094238-7	2020	In conclusion, we demonstrate that artemisinin may protect the aortas from atherosclerotic lesions by suppression of inflammatory reaction via AMPK/NF-kappaB/NLRP3 inflammasomes signalling in macrophages.	artemisinin	35-46	NLR family, pyrin domain containing 3	Mus musculus	158-163
33227837-0	2020	Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning.	Oxygen	22-28	NLR family, pyrin domain containing 3	Mus musculus	32-37
31873049-8	2020	In addition, progesterone decreased the expression of inflammatory genes related to neuroinflammation (IL-1beta, TNF-alpha, TLR4 and NLRP3) as well as increased the antioxidant capacity and decreased the lipid peroxidation (MDA) in the hippocampus.Discussion and Conclusion: Administration of progesterone significantly mitigated the negative effects of MS on behaviours relevant to depressive-like behaviour as well as attenuated neuro-immune response and oxidative stress in the hippocampus of MS mice.	Progesterone	13-25	NLR family, pyrin domain containing 3	Mus musculus	133-138
33176317-0	2020	Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson"s Disease.	(melle-4)cyclosporin	65-71	NLR family, pyrin domain containing 3	Mus musculus	15-20
33176317-0	2020	Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson"s Disease.	Rotenone	75-83	NLR family, pyrin domain containing 3	Mus musculus	15-20
33176317-16	2020	The protein expression of NLRP3, caspase-1, pro-caspase-1, GSDMD, IL-18, and IL-1beta was significantly increased after 24 h of rotenone incubation.	Rotenone	128-136	NLR family, pyrin domain containing 3	Mus musculus	26-31
33176317-17	2020	NIM811 suppressed rotenone-induced pyroptosis and downregulated the protein expression of NLRP3, caspase-1, pro-caspase-1, GSDMD, IL-1beta, and IL-18.	(melle-4)cyclosporin	0-6	NLR family, pyrin domain containing 3	Mus musculus	90-95
33176317-18	2020	CONCLUSION: These results provide evidence that rotenone activates the NLRP3 inflammomere and induces pyroptosis.	Rotenone	48-56	NLR family, pyrin domain containing 3	Mus musculus	71-76
33176317-19	2020	NIM811 protects the cell from rotenone-induced damage and inhibits NLRP3 inflammasome and pyroptosis.	(melle-4)cyclosporin	0-6	NLR family, pyrin domain containing 3	Mus musculus	67-72
31814281-0	2020	A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.	dioscin	36-43	NLR family, pyrin domain containing 3	Mus musculus	6-11
31814281-5	2020	The decrease in mRNA and protein levels of NLRP3, Caspase-1, and IL-1beta is observed in dioscin treated mouse macrophages.	dioscin	89-96	NLR family, pyrin domain containing 3	Mus musculus	43-48
32705666-1	2020	AIM: The aim of this investigation was to determine whether melatonin (MLT) mitigates white matter (WM) injury by attenuating NOD-like receptor family pyrin domain-containing 3 (NLRP3)-associated oligodendrocyte apoptosis after subarachnoid hemorrhage (SAH).	Melatonin	60-69	NLR family, pyrin domain containing 3	Mus musculus	126-176
32705666-1	2020	AIM: The aim of this investigation was to determine whether melatonin (MLT) mitigates white matter (WM) injury by attenuating NOD-like receptor family pyrin domain-containing 3 (NLRP3)-associated oligodendrocyte apoptosis after subarachnoid hemorrhage (SAH).	Melatonin	60-69	NLR family, pyrin domain containing 3	Mus musculus	178-183
31790902-0	2020	Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.	Phloretin	0-9	NLR family, pyrin domain containing 3	Mus musculus	89-94
33227837-0	2020	Effects of hyperbaric oxygen on NLRP3 inflammasome activation in the brain after carbon monoxide poisoning.	Carbon Monoxide	81-96	NLR family, pyrin domain containing 3	Mus musculus	32-37
31790902-13	2020	CONCLUSIONS: Phloretin could effectively attenuate UA-induced renal injury via co-inhibiting NLRP3 and UA reabsorption, and thus it might be a potential therapy to hyperuricemia-related renal diseases.	Phloretin	13-22	NLR family, pyrin domain containing 3	Mus musculus	93-98
31790902-13	2020	CONCLUSIONS: Phloretin could effectively attenuate UA-induced renal injury via co-inhibiting NLRP3 and UA reabsorption, and thus it might be a potential therapy to hyperuricemia-related renal diseases.	Uric Acid	51-53	NLR family, pyrin domain containing 3	Mus musculus	93-98
33227837-3	2020	In this study we investigated the effects of hyperbaric oxygen (HBO2) on NLRP3 inflammasome activation after ACOP.	Oxygen	56-62	NLR family, pyrin domain containing 3	Mus musculus	73-78
31841118-10	2019	In contrast, overexpression of XIAP by transfection in vitro restrained PA-stimulated hepatic steatosis by suppression of oxidative stress, NLRP3 related inflammatory response, and impairment of Nrf2 activity, further alleviating abnormal metabolic disorder associated NAFLD.	Palmitates	72-74	NLR family, pyrin domain containing 3	Mus musculus	140-145
31882798-1	2019	Oxalate crystal-induced renal inflammation is associated with progressive kidney failure due to activation of the NLRP3/CASP-1 inflammasome.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	114-119
31561077-8	2019	The expression of NLRP3, NLRP6 and IL-18 protein in the lung tissues of mice exposed to B(a)p plus LPS was upregulated significantly compared with those in Vehicle control group.	Benzo(a)pyrene	88-93	NLR family, pyrin domain containing 3	Mus musculus	18-23
31920554-8	2019	Moreover, immunofluorescence staining and western-blot showed that the expression of NLRP3 inflammasome and its associated proteins in neurons and microglia was inhibited by meisoindigo.	N-methylisoindigotin	174-185	NLR family, pyrin domain containing 3	Mus musculus	85-90
31920554-9	2019	The effects of Meisoindigo on NLRP3 inflammasome inactivation and increased the M2 phenotype of microglia/macrophage through shifting from a M1 phenotype, which was possibly mediated by inhibition of TLR4/NF-kappaB.	N-methylisoindigotin	15-26	NLR family, pyrin domain containing 3	Mus musculus	30-35
31920554-13	2019	After suffering OGD/R, the TLR4/NF-kappaB pathway was activated, the expression of NLRP3 inflammasome-associated proteins and M1 microglia/macrophage were increased, but meisoindigo could inhibit above changes in both HT-22 and BV2 cells.	N-methylisoindigotin	170-181	NLR family, pyrin domain containing 3	Mus musculus	83-88
31920554-14	2019	Additionally, though lipopolysaccharide stimulated the activation of TLR4 signaling in OGD/R models, meisoindigo co-treatment markedly reversed the upregulation of TLR4 and following activation of NLRP3 inflammasome and polarization of M1 microglia/macrophages mediated by TLR4.	N-methylisoindigotin	101-112	NLR family, pyrin domain containing 3	Mus musculus	197-202
31920554-15	2019	Overall, we demonstrate for the first time that meisoindigo post-treatment alleviates brain damage induced by ischemic stroke in vivo and in vitro experiments through blocking activation of the NLRP3 inflammasome and regulating the polarization of microglia/macrophages via inhibition of the TLR4/NF-kappaB signaling pathway.	N-methylisoindigotin	48-59	NLR family, pyrin domain containing 3	Mus musculus	194-199
31920554-0	2019	Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-kappaB Signaling Pathway.	N-methylisoindigotin	0-11	NLR family, pyrin domain containing 3	Mus musculus	86-91
31561077-0	2019	Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?	benzo(a	109-116	NLR family, pyrin domain containing 3	Mus musculus	3-8
31561077-0	2019	Is NLRP3 or NLRP6 inflammasome activation associated with inflammation-related lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide?	pyrene	117-123	NLR family, pyrin domain containing 3	Mus musculus	3-8
31561077-11	2019	In conclusion, our results from this study demonstrate that NLRP3 inflammasome, not NLRP6 inflammasome, activation is involved in B(a)p plus LPS-induced inflammation-related lung tumorigenesis in mice, but the mechanisms of NLRP6 participate in the development of lung cancer should be further investigated.	Benzo(a)pyrene	130-135	NLR family, pyrin domain containing 3	Mus musculus	60-65
31733211-8	2019	Collectively, our data suggest that nicotine enhances cathepsin B-dependent Nlrp3 inflammasome activation and the consequent production of a novel permeability factor HMGB1, which causes disruption of inter-endothelial tight junctions leading to endothelial hyperpermeability.	Nicotine	36-44	NLR family, pyrin domain containing 3	Mus musculus	76-81
31733211-0	2019	Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction.	Nicotine	71-79	NLR family, pyrin domain containing 3	Mus musculus	38-43
31705915-10	2019	Using siRNA and Lenti-Virus to inhibit NLRP3 abolished palmitate-induced IL-1beta release and restored impaired phosphorylation of IRS-1 (Tyr), Akt (Ser473) and eNOS (Ser1177) and ACh-mediated endothelium-dependent vasorelaxation induced by palmitate.	Palmitates	241-250	NLR family, pyrin domain containing 3	Mus musculus	39-44
31733211-3	2019	This study aims to investigate the role of endothelial Nlrp3 inflammasome in nicotine-induced disruption of inter-endothelial tight junctions and consequent endothelial barrier dysfunction.	Nicotine	77-85	NLR family, pyrin domain containing 3	Mus musculus	55-60
31733211-4	2019	The confocal microscopic analysis demonstrated that mice treated with nicotine exhibited disrupted inter-endothelial tight junctions as shown by decreased ZO-1 and ZO-2 expression in the coronary arterial endothelium, whereas the decreases in ZO-1/2 were prevented by Nlrp3 gene deficiency.	Nicotine	70-78	NLR family, pyrin domain containing 3	Mus musculus	268-273
31733211-5	2019	In cultured endothelial cells, nicotine caused Nlrp3 inflammasome complex formation and enhances the inflammasome activity as shown by increased cleavage of pro-caspase-1, and interleukin-1beta (IL-1beta) production.	Nicotine	31-39	NLR family, pyrin domain containing 3	Mus musculus	47-52
31733211-6	2019	Further, nicotine disrupted tight junction and increased permeability in an endothelial cell monolayer, and this nicotine-induced effect was prevented by silencing of Nlrp3 gene, inhibition of caspase-1, or blockade of high mobility group box 1 (HMGB1).	Nicotine	9-17	NLR family, pyrin domain containing 3	Mus musculus	167-172
31733211-6	2019	Further, nicotine disrupted tight junction and increased permeability in an endothelial cell monolayer, and this nicotine-induced effect was prevented by silencing of Nlrp3 gene, inhibition of caspase-1, or blockade of high mobility group box 1 (HMGB1).	Nicotine	113-121	NLR family, pyrin domain containing 3	Mus musculus	167-172
31705915-11	2019	AMPKalpha activator AICAR(5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside) inhibited NLRP3 inflammasome activation and decreased IL-1beta release and restored impaired insulin signal pathway induced by palmitate.	AICA ribonucleotide	20-25	NLR family, pyrin domain containing 3	Mus musculus	93-98
31705915-0	2019	NLRP3 inflammasome mediate palmitate-induced endothelial dysfunction.	Palmitates	27-36	NLR family, pyrin domain containing 3	Mus musculus	0-5
31738882-0	2019	Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	116-121
31705915-10	2019	Using siRNA and Lenti-Virus to inhibit NLRP3 abolished palmitate-induced IL-1beta release and restored impaired phosphorylation of IRS-1 (Tyr), Akt (Ser473) and eNOS (Ser1177) and ACh-mediated endothelium-dependent vasorelaxation induced by palmitate.	Palmitates	55-64	NLR family, pyrin domain containing 3	Mus musculus	39-44
31705915-10	2019	Using siRNA and Lenti-Virus to inhibit NLRP3 abolished palmitate-induced IL-1beta release and restored impaired phosphorylation of IRS-1 (Tyr), Akt (Ser473) and eNOS (Ser1177) and ACh-mediated endothelium-dependent vasorelaxation induced by palmitate.	Tyrosine	138-141	NLR family, pyrin domain containing 3	Mus musculus	39-44
31705915-11	2019	AMPKalpha activator AICAR(5-aminoimidazole-4-carbox-amide-1-beta-d-ribofuranoside) inhibited NLRP3 inflammasome activation and decreased IL-1beta release and restored impaired insulin signal pathway induced by palmitate.	acadesine	26-81	NLR family, pyrin domain containing 3	Mus musculus	93-98
31705915-12	2019	SIGNIFICANCE: NLRP3 inflammasome activation via AMPKalpha inactivation mediated palmitate-induced endothelial dysfunction through involves IL-1beta-induced insulin signal pathway.	ampkalpha	48-57	NLR family, pyrin domain containing 3	Mus musculus	14-19
31705915-12	2019	SIGNIFICANCE: NLRP3 inflammasome activation via AMPKalpha inactivation mediated palmitate-induced endothelial dysfunction through involves IL-1beta-induced insulin signal pathway.	Palmitates	80-89	NLR family, pyrin domain containing 3	Mus musculus	14-19
31738882-10	2019	Blocking the effect of endogenous melatonin by Luzindole abolished the suppressive effect of CpG-ODN on OVA-induced airway inflammation and activation of NLRP3 inflammasome, suggesting such effect was mediated by endogenous melatonin.	Melatonin	34-43	NLR family, pyrin domain containing 3	Mus musculus	154-159
31738882-10	2019	Blocking the effect of endogenous melatonin by Luzindole abolished the suppressive effect of CpG-ODN on OVA-induced airway inflammation and activation of NLRP3 inflammasome, suggesting such effect was mediated by endogenous melatonin.	luzindole	47-56	NLR family, pyrin domain containing 3	Mus musculus	154-159
31738882-10	2019	Blocking the effect of endogenous melatonin by Luzindole abolished the suppressive effect of CpG-ODN on OVA-induced airway inflammation and activation of NLRP3 inflammasome, suggesting such effect was mediated by endogenous melatonin.	Melatonin	224-233	NLR family, pyrin domain containing 3	Mus musculus	154-159
31738882-11	2019	Moreover, exogenous melatonin pronouncedly ameliorated airway inflammation and decreased the activation of NLRP3 inflammasome.	Melatonin	20-29	NLR family, pyrin domain containing 3	Mus musculus	107-112
31738882-12	2019	SIGNIFICANCE: These results proven that CpG-ODN protects against allergic airway inflammation via suppressing the activation of NLRP3 inflammasome, and such effect may be resulted from the restored-production of melatonin.	Melatonin	212-221	NLR family, pyrin domain containing 3	Mus musculus	128-133
31849516-0	2019	NLRP3 Inflammasome Mediated Interleukin-1beta Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma.	1-phenyl-3,3-dimethyltriazene	104-111	NLR family, pyrin domain containing 3	Mus musculus	0-5
33273997-6	2019	In parallel, PS-ALA blocked Nlrp3 activation and reduced release of IL-1beta and IL-18 via inhibiting ER stress-induced sensitization of unfolded protein response sensors (Ire1alpha and Xbp1s).	ps-ala	13-19	NLR family, pyrin domain containing 3	Mus musculus	28-33
31849516-8	2019	Furthermore, NLRP3-inflammasome and p-p65/p65 were elevated after ALA-PDT mediated IL1beta production in cancer-associated-fibroblasts.	delta-aminolevulinic acid methyl ester	66-69	NLR family, pyrin domain containing 3	Mus musculus	13-18
31388087-11	2019	We showed that compared with MPTP-treated WT mice, TLR4 deficiency significantly attenuated MPTP-induced motor deficits and TH-protein expression reduction in SNpc and striatum, suppressed MPTP-induced alpha-synuclein abnormality and neuroinflammation mediated through oxidative stress, glial activation, NF-kappaB and the NLRP3 inflammasome signaling pathways.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	92-96	NLR family, pyrin domain containing 3	Mus musculus	323-328
31787755-7	2019	NEK7 interacted with NLRP3, as revealed by Co-IP and GST pull-down assays, to exert its effects.	inositol 2,4,5-trisphosphate	43-48	NLR family, pyrin domain containing 3	Mus musculus	21-26
31789603-7	2019	Inhibition of NLRP3 or NF-kappaB by Bay11-7082 resulted in reduction of KA-induced IL-1beta production.	3-(4-methylphenylsulfonyl)-2-propenenitrile	36-46	NLR family, pyrin domain containing 3	Mus musculus	14-19
31817997-4	2019	Here, we tested the hypothesis that an excess of aldosterone induces vascular dysfunction in type 2 diabetes, via the activation of mineralocorticoid receptors (MR) and assembly of the NLRP3 inflammasome.	Aldosterone	49-60	NLR family, pyrin domain containing 3	Mus musculus	185-190
31319679-3	2019	Results: Exposure of mouse peritoneal macrophages (PMs) to lipopolysaccharide (LPS) plus ATP caused NLRP3 inflammasome activation, together with an increased connexin43 (Cx43).	Adenosine Triphosphate	89-92	NLR family, pyrin domain containing 3	Mus musculus	100-105
31411068-7	2019	Knockdown of NLRP3 or Caspase-1 or treatments with SS-31 or YVAD inhibited the expression of the NLRP3 inflammasome, and reduced IL-1beta and IL-18 levels in cell supernatant.	YVAD	60-64	NLR family, pyrin domain containing 3	Mus musculus	97-102
31411068-7	2019	Knockdown of NLRP3 or Caspase-1 or treatments with SS-31 or YVAD inhibited the expression of the NLRP3 inflammasome, and reduced IL-1beta and IL-18 levels in cell supernatant.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	51-56	NLR family, pyrin domain containing 3	Mus musculus	97-102
31647995-4	2019	Using a streptozotocin (STZ)-induced diabetes mouse model, we found that endothelium-specific AC gene knockout mice (Asah1fl/fl/ECcre) significantly enhanced the formation and activation of NLRP3 inflammasomes in coronary arterial ECs (CECs).	Streptozocin	24-27	NLR family, pyrin domain containing 3	Mus musculus	190-195
31677073-0	2019	Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice.	Carbamazepine	0-13	NLR family, pyrin domain containing 3	Mus musculus	48-53
31677073-4	2019	Here we report that CBZ causes idiosyncratic liver injury through promoting specific stimuli-induced NLRP3 inflammasome activation.	Carbamazepine	20-23	NLR family, pyrin domain containing 3	Mus musculus	101-106
31677073-5	2019	CBZ (40 muM) enhances NLRP3 inflammasome activation triggered by adenosine triphosphate (ATP) or nigericin, rather than SiO2, monosodium urate crystal or intracellular lipopolysaccharide (LPS).	Carbamazepine	0-3	NLR family, pyrin domain containing 3	Mus musculus	22-27
31677073-5	2019	CBZ (40 muM) enhances NLRP3 inflammasome activation triggered by adenosine triphosphate (ATP) or nigericin, rather than SiO2, monosodium urate crystal or intracellular lipopolysaccharide (LPS).	Adenosine Triphosphate	65-87	NLR family, pyrin domain containing 3	Mus musculus	22-27
31677073-5	2019	CBZ (40 muM) enhances NLRP3 inflammasome activation triggered by adenosine triphosphate (ATP) or nigericin, rather than SiO2, monosodium urate crystal or intracellular lipopolysaccharide (LPS).	Adenosine Triphosphate	89-92	NLR family, pyrin domain containing 3	Mus musculus	22-27
31677073-5	2019	CBZ (40 muM) enhances NLRP3 inflammasome activation triggered by adenosine triphosphate (ATP) or nigericin, rather than SiO2, monosodium urate crystal or intracellular lipopolysaccharide (LPS).	Nigericin	97-106	NLR family, pyrin domain containing 3	Mus musculus	22-27
31677073-7	2019	Mechanistically, synergistic induction of mitochondrial reactive oxygen species (mtROS) is a crucial event in the enhancement effect of CBZ on ATP- or nigericin-induced NLRP3 inflammasome activation.	Oxygen	65-71	NLR family, pyrin domain containing 3	Mus musculus	169-174
31677073-7	2019	Mechanistically, synergistic induction of mitochondrial reactive oxygen species (mtROS) is a crucial event in the enhancement effect of CBZ on ATP- or nigericin-induced NLRP3 inflammasome activation.	Carbamazepine	136-139	NLR family, pyrin domain containing 3	Mus musculus	169-174
31677073-7	2019	Mechanistically, synergistic induction of mitochondrial reactive oxygen species (mtROS) is a crucial event in the enhancement effect of CBZ on ATP- or nigericin-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	143-146	NLR family, pyrin domain containing 3	Mus musculus	169-174
31677073-7	2019	Mechanistically, synergistic induction of mitochondrial reactive oxygen species (mtROS) is a crucial event in the enhancement effect of CBZ on ATP- or nigericin-induced NLRP3 inflammasome activation.	Nigericin	151-160	NLR family, pyrin domain containing 3	Mus musculus	169-174
31677073-8	2019	Moreover, the "C=C" on the seven-membered ring and "C=O" on the nitrogen of CBZ may be contribute to NLRP3 inflammasome hyperactivation and hepatotoxicity.	Nitrogen	64-72	NLR family, pyrin domain containing 3	Mus musculus	101-106
31677073-8	2019	Moreover, the "C=C" on the seven-membered ring and "C=O" on the nitrogen of CBZ may be contribute to NLRP3 inflammasome hyperactivation and hepatotoxicity.	Carbamazepine	76-79	NLR family, pyrin domain containing 3	Mus musculus	101-106
31677073-9	2019	Notably, in vivo data indicate that CBZ (50 mg/kg) causes liver injury in an LPS (2 mg/kg)-mediated susceptibility mouse model of IDILI, accompanied by an increase in caspase-1 activity and IL-1beta production, whereas the combination of CBZ and LPS does not exhibit the effect in NLRP3-knockout mice.	Carbamazepine	36-39	NLR family, pyrin domain containing 3	Mus musculus	281-286
31677073-10	2019	In conclusion, CBZ specifically promotes ATP- or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury.	Carbamazepine	15-18	NLR family, pyrin domain containing 3	Mus musculus	67-72
31677073-10	2019	In conclusion, CBZ specifically promotes ATP- or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury.	Adenosine Triphosphate	41-44	NLR family, pyrin domain containing 3	Mus musculus	67-72
31677073-10	2019	In conclusion, CBZ specifically promotes ATP- or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury.	Nigericin	49-58	NLR family, pyrin domain containing 3	Mus musculus	67-72
31347703-8	2019	Amelioration of pancreatic damage by butyrate was associated with reduced levels of TNF-alpha, IL-6 and MCP-1 and suppressed NLRP3 inflammasome activation in both pancreas and colon.	Butyrates	37-45	NLR family, pyrin domain containing 3	Mus musculus	125-130
31347703-9	2019	Further mechanistic investigations revealed that butyrate ameliorated pancreatic inflammation by suppressing interaction between histone deacetylase 1 (HDAC1) and AP1 and STAT1 with increased histone acetylation at H3K9, H3K14, H3K18 and H3K27 loci, resulting in suppressed NLRP3 inflammasome activation and modulated immune cell infiltration in pancreas.	Butyrates	49-57	NLR family, pyrin domain containing 3	Mus musculus	274-279
31347703-10	2019	Additionally, butyrate mediated STAT1/AP1-NLRP3 inflammasome suppression via HDAC1 inhibition was demonstrated in peritoneal macrophage.	Butyrates	14-22	NLR family, pyrin domain containing 3	Mus musculus	42-47
31347703-11	2019	In colon, butyrate inhibited NLRP3 inflammasome activation via GPR109A.	Butyrates	10-18	NLR family, pyrin domain containing 3	Mus musculus	29-34
31137980-10	2019	Inhibition of hydrogen peroxide production from superoxide anions in the gp91phox-/- status prevented the increased TEWL and decreased skin hydration level noted with degradation of NLRP3 and caspase-1.	Hydrogen Peroxide	14-31	NLR family, pyrin domain containing 3	Mus musculus	182-187
31137980-10	2019	Inhibition of hydrogen peroxide production from superoxide anions in the gp91phox-/- status prevented the increased TEWL and decreased skin hydration level noted with degradation of NLRP3 and caspase-1.	Superoxides	48-58	NLR family, pyrin domain containing 3	Mus musculus	182-187
30612217-8	2019	Naringenin also inhibited inflammasome upregulation (reduced Nlrp3, ASC, caspase-1, and pro-IL-1beta mRNA expression) and oxidative stress (reduced gp91phox mRNA expression and superoxide anion production, increased GSH levels, induced Nrf2 protein in CD45+ hematopoietic recruited cells, and induced Nrf2 and HO-1 mRNA expression).	naringenin	0-10	NLR family, pyrin domain containing 3	Mus musculus	61-66
30877711-3	2019	Here, we report that the renoprotective effect of gemigliptin is associated with a reduction in NLRP3-mediated inflammation in a murine model of renal fibrosis.	LC15-0444	50-61	NLR family, pyrin domain containing 3	Mus musculus	96-101
31689135-0	2019	Serelaxin inhibits the profibrotic TGF-beta1/IL-1beta axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts.	serelaxin protein, human	0-9	NLR family, pyrin domain containing 3	Mus musculus	86-91
31689135-3	2019	HCMFs stimulated with TGF-beta1 (5 ng/ml), LPS (100 ng/ml), and ATP (5 mM) (T+L+A) for 8 h, to induce the NLRP3 inflammasome, demonstrated significantly increased protein expression of markers of NLRP3 priming (NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain, procaspase-1) and activity (IL-1beta, IL-18).	hcmfs	0-5	NLR family, pyrin domain containing 3	Mus musculus	106-111
31689135-3	2019	HCMFs stimulated with TGF-beta1 (5 ng/ml), LPS (100 ng/ml), and ATP (5 mM) (T+L+A) for 8 h, to induce the NLRP3 inflammasome, demonstrated significantly increased protein expression of markers of NLRP3 priming (NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain, procaspase-1) and activity (IL-1beta, IL-18).	hcmfs	0-5	NLR family, pyrin domain containing 3	Mus musculus	196-201
31689135-3	2019	HCMFs stimulated with TGF-beta1 (5 ng/ml), LPS (100 ng/ml), and ATP (5 mM) (T+L+A) for 8 h, to induce the NLRP3 inflammasome, demonstrated significantly increased protein expression of markers of NLRP3 priming (NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain, procaspase-1) and activity (IL-1beta, IL-18).	hcmfs	0-5	NLR family, pyrin domain containing 3	Mus musculus	196-201
31689135-3	2019	HCMFs stimulated with TGF-beta1 (5 ng/ml), LPS (100 ng/ml), and ATP (5 mM) (T+L+A) for 8 h, to induce the NLRP3 inflammasome, demonstrated significantly increased protein expression of markers of NLRP3 priming (NLRP3, apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain, procaspase-1) and activity (IL-1beta, IL-18).	Adenosine Triphosphate	64-67	NLR family, pyrin domain containing 3	Mus musculus	106-111
31485755-11	2019	CONCLUSION: Taken together, our study suggests that deubiquitinating enzyme BRCC36 inhibition could potentially suppress oxLDL-induced inflammatory process by inhibiting NLRP3 activation and resultant IL-1beta secretion.	brcc36	76-82	NLR family, pyrin domain containing 3	Mus musculus	170-175
31232472-0	2019	MicroRNA-190 alleviates neuronal damage and inhibits neuroinflammation via Nlrp3 in MPTP-induced Parkinson"s disease mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	84-88	NLR family, pyrin domain containing 3	Mus musculus	75-80
31735662-0	2019	Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-kappaB/NLRP3 pathway.	Propofol	0-8	NLR family, pyrin domain containing 3	Mus musculus	159-164
31735662-10	2019	Besides, NLRP3 inflammasome and TLR4/NF-kappaB pathway were inactivated under the treatment of propofol according to the expression of pathways-related proteins.	Propofol	95-103	NLR family, pyrin domain containing 3	Mus musculus	9-14
31735662-11	2019	CONCLUSION: Taken together, propofol contributed to liver protection against d-GalN/LPS-induced liver injury in mice by inhibiting inflammation, oxidative stress and hepatocyte apoptosis through regulating TLR4/NF-kappaB/NLRP3 pathway.	Propofol	28-36	NLR family, pyrin domain containing 3	Mus musculus	221-226
31232472-11	2019	In conclusion, we demonstrated that miR-190 alleviates neuronal damage and inhibits inflammation via negatively regulating the expression and activation of Nlrp3 in MPTP-induced PD mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	165-169	NLR family, pyrin domain containing 3	Mus musculus	156-161
31689519-9	2019	The results showed that FMT, like phloretin, ameliorated UC by improving disease symptoms and colon inflammation, balancing inflammatory cytokines, maintaining intestinal barrier integrity, restoring systemic immune function, inhibiting NF-kappaB and NLRP3 inflammasome activation and ameliorating the oxidant stress.	fmt	24-27	NLR family, pyrin domain containing 3	Mus musculus	251-256
31586460-7	2019	Our result showed that chronic treatment with stress hormone corticosterone increased Txnip protein levels and Txnip-NLRP3 binding in N9 mouse microglia, in primary cultured mouse microglia and in mouse brain.	Corticosterone	61-75	NLR family, pyrin domain containing 3	Mus musculus	117-122
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	NLR family, pyrin domain containing 3	Mus musculus	96-101
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	NLR family, pyrin domain containing 3	Mus musculus	127-132
31586460-11	2019	It is therefore likely that Txnip-activated NLRP3 inflammasome contributes to corticosterone-caused neuroinflammation.	Corticosterone	78-92	NLR family, pyrin domain containing 3	Mus musculus	44-49
31597697-0	2019	NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation.	treg	27-31	NLR family, pyrin domain containing 3	Mus musculus	0-5
32237395-0	2019	[Triptolide inhibits NLRP3 inflammasome activation and ameliorates podocyte epithelial-mesenchymal transition induced by high glucose].	triptolide	1-11	NLR family, pyrin domain containing 3	Mus musculus	21-26
31849693-7	2019	Furthermore, farrerol attenuated the phosphorylation of C-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (p38); the activation of phosphorylated nuclear factor-kappaB (p-NF-kappaB) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3); and the expression of phosphorylated p53 (p-p53), Bax, and cleaved caspase-3.	farrerol	13-21	NLR family, pyrin domain containing 3	Mus musculus	310-315
31597697-5	2019	NLRP3-deficient mice elevate Treg generation in various organs in the de novo pathway.	treg	29-33	NLR family, pyrin domain containing 3	Mus musculus	0-5
31597697-7	2019	Importantly, NLRP3 interacted with Kpna2 and translocated to the nucleus from the cytoplasm under Treg-polarizing conditions.	treg	98-102	NLR family, pyrin domain containing 3	Mus musculus	13-18
31597697-8	2019	Taken together, our results identify a novel role for NLRP3 as a new negative regulator of Treg differentiation, mediated via its interaction with Kpna2 for nuclear translocation.	treg	91-95	NLR family, pyrin domain containing 3	Mus musculus	54-59
31885813-0	2019	Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression.	resveratrol	10-27	NLR family, pyrin domain containing 3	Mus musculus	138-143
31657406-5	2019	When using the microglial BV2 cells to investigate the underlying mechanisms, we found that the NLRP3 inflammasome activation was involved in the IL-1beta-mediated inflammation induced by Ag2Se QDs.	Silver	188-193	NLR family, pyrin domain containing 3	Mus musculus	96-101
31885813-0	2019	Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression.	4,7-dihydroxy-5-methoxy-6-methyl-8-formylflavan	35-60	NLR family, pyrin domain containing 3	Mus musculus	138-143
31570558-0	2019	Taurine alleviates schistosoma-induced liver injury by inhibiting TXNIP/NLRP3 inflammasome signal pathway and pyroptosis.	Taurine	0-7	NLR family, pyrin domain containing 3	Mus musculus	72-77
31611307-5	2019	SAA induced the expression of NLRP3 which mediated IL-1beta induction in murine BV-2 cells and both sex primary mouse microglial cells, in a dose and time dependent fashion.	Gonadal Steroid Hormones	100-103	NLR family, pyrin domain containing 3	Mus musculus	30-35
31685616-3	2019	Based on our mechanistic investigations in vitro and in vivo, 1) the capability of DAPPD to restore microglial phagocytosis is responsible for diminishing the accumulation of amyloid-beta (Abeta) species and significantly improving cognitive function in the brains of 2 types of Alzheimer"s disease (AD) transgenic mice, and 2) the rectification of microglial function by DAPPD is a result of its ability to suppress the expression of NLRP3 inflammasome-associated proteins through its impact on the NF-kappaB pathway.	dappd	83-88	NLR family, pyrin domain containing 3	Mus musculus	435-440
31570558-7	2019	Furthermore, taurine suppressed the activation of hepatic thioredoxin-interacting protein (TXNIP)/NLRP3 inflammasome in mice with S. japonicum infection, thereby inhibiting the activation of downstream inflammatory mediators such as interleukin-1beta and subsequent pyroptosis.	Taurine	13-20	NLR family, pyrin domain containing 3	Mus musculus	98-103
31570558-3	2019	Previous studies have indicated that NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is involved in schistosomiasis-associated liver fibrosis and that taurine could ameliorate hepatic granuloma and fibrosis caused by Schistosoma japonicum infection.	Taurine	175-182	NLR family, pyrin domain containing 3	Mus musculus	89-94
31612242-5	2019	In vivo, AFB1-treated mice exhibited NLRP3 inflammasome activation, inflammatory infiltration, and increased recruitment of KCs.	Aflatoxin B1	9-13	NLR family, pyrin domain containing 3	Mus musculus	37-42
31803174-3	2019	MSU crystals engage the Nlrp3 inflammasome, leading to the activation of caspase-1 and production of IL-1beta and IL-18 within gout-affected joints, promoting the influx of neutrophils and monocytes.	Uric Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	24-29
31814820-9	2019	In conclusion, the study indicates that MFX relieves a depressive-like state in LPS-induced mice through the inhibition of the NLRP3 inflammasome and the enhancement of the neurogenesis pathway.	Moxifloxacin	40-43	NLR family, pyrin domain containing 3	Mus musculus	127-132
31533918-3	2019	Here we demonstrate that conditioning regimen-induced adenosine triphosphate (ATP) release is a primary driver of MDSC dysfunction through ATP receptor (P2x7R) engagement and NLR pyrin family domain 3 (NLRP3) inflammasome activation.	Adenosine	54-63	NLR family, pyrin domain containing 3	Mus musculus	202-207
31533918-3	2019	Here we demonstrate that conditioning regimen-induced adenosine triphosphate (ATP) release is a primary driver of MDSC dysfunction through ATP receptor (P2x7R) engagement and NLR pyrin family domain 3 (NLRP3) inflammasome activation.	Adenosine Triphosphate	78-81	NLR family, pyrin domain containing 3	Mus musculus	202-207
31700106-8	2019	ICP/MAP and sodium nitroprusside (SNP)-induced relaxation in CC were decreased in NLRP3-/- mice.	Nitroprusside	12-32	NLR family, pyrin domain containing 3	Mus musculus	82-87
31700106-13	2019	LPS + ATP increased NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Adenosine Triphosphate	6-9	NLR family, pyrin domain containing 3	Mus musculus	20-25
31700106-15	2019	NLRP3 plays a dual role in CC relaxation, with its inhibition leading to impairment of nitric oxide-mediated relaxation, while its activation by LPS + ATP causes decreased CC sensitivity to NO and endothelium-dependent relaxation.	Nitric Oxide	87-99	NLR family, pyrin domain containing 3	Mus musculus	0-5
31700106-15	2019	NLRP3 plays a dual role in CC relaxation, with its inhibition leading to impairment of nitric oxide-mediated relaxation, while its activation by LPS + ATP causes decreased CC sensitivity to NO and endothelium-dependent relaxation.	Adenosine Triphosphate	151-154	NLR family, pyrin domain containing 3	Mus musculus	0-5
31865729-10	2019	Moreover, we found that the overexpression of miR-155 promoted the activation of the ox-LDL-induced NLRP3 inflammasome, which could also be blocked by the ERK inhibitor U0126.	U 0126	169-174	NLR family, pyrin domain containing 3	Mus musculus	100-105
31612242-8	2019	Furthermore, pyroptosis and inflammatory response induced by AFB1 were relieved with COX-2 genetic (siPTGS2) intervention or pharmaceutic (celecoxib, 30 mg/kg body weight, i.g, 4 weeks) inhibition of COX-2 via NLRP3 inflammasome suppression in vivo and in vitro.	Aflatoxin B1	61-65	NLR family, pyrin domain containing 3	Mus musculus	210-215
31542387-0	2019	Mitophagy protects against acetaminophen-induced acute liver injury in mice through inhibiting NLRP3 inflammasome activation.	Acetaminophen	27-40	NLR family, pyrin domain containing 3	Mus musculus	95-100
31518877-0	2019	Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE-/- mice.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	20-47
31518877-1	2019	AIMS: The present study aimed to investigate the effect of metformin on diabetes-accelerated atherosclerosis and whether Nod-like receptor protein 3 (NLRP3) inflammasome is a target for metformin.	Metformin	186-195	NLR family, pyrin domain containing 3	Mus musculus	121-148
31518877-1	2019	AIMS: The present study aimed to investigate the effect of metformin on diabetes-accelerated atherosclerosis and whether Nod-like receptor protein 3 (NLRP3) inflammasome is a target for metformin.	Metformin	186-195	NLR family, pyrin domain containing 3	Mus musculus	150-155
31518877-7	2019	In vitro experiments showed that high glucose induced the accumulation of reactive oxygen species and activated NLRP3 inflammasomes, which was significantly suppressed by treatment with metformin or antioxidant N-acetyl-L-cysteine.	Glucose	38-45	NLR family, pyrin domain containing 3	Mus musculus	112-117
31518877-7	2019	In vitro experiments showed that high glucose induced the accumulation of reactive oxygen species and activated NLRP3 inflammasomes, which was significantly suppressed by treatment with metformin or antioxidant N-acetyl-L-cysteine.	Metformin	186-195	NLR family, pyrin domain containing 3	Mus musculus	112-117
31542387-12	2019	By contrast, pretreatment with CQ further enhanced NLRP3 inflammasome signaling pathway.	Chloroquine	31-33	NLR family, pyrin domain containing 3	Mus musculus	51-56
31542387-11	2019	Notably, RAPA significantly inhibited the activation of NF-kB and NLRP3 inflammasome and the production of IL-1beta in APAP-treated mice.	Sirolimus	9-13	NLR family, pyrin domain containing 3	Mus musculus	66-71
31518877-7	2019	In vitro experiments showed that high glucose induced the accumulation of reactive oxygen species and activated NLRP3 inflammasomes, which was significantly suppressed by treatment with metformin or antioxidant N-acetyl-L-cysteine.	Acetylcysteine	211-230	NLR family, pyrin domain containing 3	Mus musculus	112-117
31518877-8	2019	Moreover, Compound C, an inhibitor of adenosine 5"-monophosphate-activated protein kinase (AMPK), blocked the anti-inflammatory effect of metformin, indicating that metformin inhibited high glucose-induced NLRP3 inflammasomes activation through AMPK activation.	Metformin	138-147	NLR family, pyrin domain containing 3	Mus musculus	206-211
31518877-8	2019	Moreover, Compound C, an inhibitor of adenosine 5"-monophosphate-activated protein kinase (AMPK), blocked the anti-inflammatory effect of metformin, indicating that metformin inhibited high glucose-induced NLRP3 inflammasomes activation through AMPK activation.	Metformin	165-174	NLR family, pyrin domain containing 3	Mus musculus	206-211
31518877-8	2019	Moreover, Compound C, an inhibitor of adenosine 5"-monophosphate-activated protein kinase (AMPK), blocked the anti-inflammatory effect of metformin, indicating that metformin inhibited high glucose-induced NLRP3 inflammasomes activation through AMPK activation.	Glucose	190-197	NLR family, pyrin domain containing 3	Mus musculus	206-211
31518877-10	2019	CONCLUSIONS: Metformin inhibited NLRP3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE-/- mice, which at least partially through activation of AMPK and regulation of thioredoxin-1/thioredoxin-interacting protein.	Metformin	13-22	NLR family, pyrin domain containing 3	Mus musculus	33-38
31376498-11	2019	Further, ethanol-induced autophagy suppressed the NLRP3 inflammatory and apoptosis pathways in the hippocampus in mice and in vitro.	Ethanol	9-16	NLR family, pyrin domain containing 3	Mus musculus	50-55
31032942-0	2019	Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high-fat high cholesterol diet via regulating NF-kappaB and NLRP3 inflammasome pathway.	Cannabidiol	0-11	NLR family, pyrin domain containing 3	Mus musculus	136-141
31419475-0	2019	Redox regulation of hepatic NLRP3 inflammasome activation and immune dysregulation in trichloroethene-mediated autoimmunity.	Trichloroethylene	86-101	NLR family, pyrin domain containing 3	Mus musculus	28-33
31419475-6	2019	Importantly, TCE exposure resulted in the activation of hepatic inflammasome (NLRP3 and caspase-1) and up-regulation of pro-inflammatory cytokine IL-1beta, and these changes were attenuated by NAC supplementation.	Trichloroethylene	13-16	NLR family, pyrin domain containing 3	Mus musculus	78-83
31419475-6	2019	Importantly, TCE exposure resulted in the activation of hepatic inflammasome (NLRP3 and caspase-1) and up-regulation of pro-inflammatory cytokine IL-1beta, and these changes were attenuated by NAC supplementation.	Acetylcysteine	193-196	NLR family, pyrin domain containing 3	Mus musculus	78-83
31520988-0	2019	Toosendanin alleviates dextran sulfate sodium-induced colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling.	Dextran Sulfate	23-45	NLR family, pyrin domain containing 3	Mus musculus	118-123
31520988-7	2019	In conclusion, our findings demonstrated that, TSN alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis.	Dextran Sulfate	62-65	NLR family, pyrin domain containing 3	Mus musculus	151-156
31520990-0	2019	Suppression of NLRP3 and NF-kappaB signaling pathways by alpha-Cyperone via activating SIRT1 contributes to attenuation of LPS-induced acute lung injury in mice.	alpha-cyperone	57-71	NLR family, pyrin domain containing 3	Mus musculus	15-20
31520990-8	2019	Meanwhile, alpha-Cyperone could downregulate NF-kappaB and NLRP3 signaling pathways.	alpha-cyperone	11-25	NLR family, pyrin domain containing 3	Mus musculus	59-64
31520990-10	2019	In conclusion, alpha-Cyperone showed the protective effect on LPS-induced ALI in mice by suppressing the NF-kappaB and NLRP3 signaling pathways, mainly via up-regulating SIRT1.	alpha-cyperone	15-29	NLR family, pyrin domain containing 3	Mus musculus	119-124
31477246-0	2019	NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing.	Glyburide	29-38	NLR family, pyrin domain containing 3	Mus musculus	0-5
31477246-2	2019	The present study aims to investigate the therapeutic effects of glyburide, an NLRP3 inflammasome inhibitor, in a diabetic-induced fracture model.	Glyburide	65-74	NLR family, pyrin domain containing 3	Mus musculus	79-84
31374144-7	2019	Finally, consistent with the results obtained in BV2 cells, EGCG treatment reduces microglial inflammation and neurotoxicity by suppressing the activation of canonical NLRP3 and noncanonical caspase-11-dependent inflammasome via TLR4/NF-kappaB pathway in LPS+Abeta-induced rat primary microglia and hippocampus of APP/PS1 mice.	epigallocatechin gallate	60-64	NLR family, pyrin domain containing 3	Mus musculus	168-173
31507096-9	2019	Moreover, p120 prevented the activation of NLRP3 and regulated NLRP3 by inhibiting the TLR4 pathway and ROS production.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	43-48
31507096-9	2019	Moreover, p120 prevented the activation of NLRP3 and regulated NLRP3 by inhibiting the TLR4 pathway and ROS production.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	63-68
31374144-8	2019	CONCLUSION: EGCG attenuates microglial inflammation and neurotoxicity by inhibition of canonical NLRP3 and noncanonical caspase-11-dependent inflammasome activation via TLR4/NF-kappaB pathway.	epigallocatechin gallate	12-16	NLR family, pyrin domain containing 3	Mus musculus	97-102
31115771-12	2019	In BV2 cells, DOI-induced inflammation mediated through TLR/NLRP3/NF-kappaB was significantly inhibited following RH administration.	rhyncophylline	114-116	NLR family, pyrin domain containing 3	Mus musculus	60-65
31737627-0	2019	D-Ribose Induces Podocyte NLRP3 Inflammasome Activation and Glomerular Injury via AGEs/RAGE Pathway.	Ribose	0-8	NLR family, pyrin domain containing 3	Mus musculus	26-31
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	NLR family, pyrin domain containing 3	Mus musculus	22-27
31295660-0	2019	Resveratrol alleviates chronic "real-world" ambient particulate matter-induced lung inflammation and fibrosis by inhibiting NLRP3 inflammasome activation in mice.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	124-129
31737627-3	2019	Given that D-ribose was reported to induce advanced glycation end products (AGEs) formation, the present study tested whether D-ribose induces NLRP3 activation and associated glomerular injury via AGEs/receptor of AGEs (RAGE) signaling pathway.	Ribose	126-134	NLR family, pyrin domain containing 3	Mus musculus	143-148
31737627-6	2019	This D-ribose-induced NLRP3 inflammasome formation was accompanied by its activation as evidenced by increased IL-1beta production, a major product of NLRP3 inflammasome.	Ribose	5-13	NLR family, pyrin domain containing 3	Mus musculus	151-156
31737627-10	2019	In cell studies, we also confirmed that D-ribose induced NLRP3 inflammasome formation and activation in podocytes, which was significantly blocked by caspase-1 inhibitor, YvAD.	Ribose	40-48	NLR family, pyrin domain containing 3	Mus musculus	57-62
31737627-5	2019	Administration of D-ribose daily for 30 days was found to induce NLRP3 inflammasome formation in glomerular podocyte, as shown by increased co-localization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Ribose	18-26	NLR family, pyrin domain containing 3	Mus musculus	65-70
31737627-11	2019	Mechanically, AGEs formation inhibition and cleavage or silencing of RAGE gene were shown to suppress D-ribose-induced NLRP3 inflammasome formation and activation, as shown by significant reduction of NLRP3 inflammasome molecular aggregation, caspase-1 activity and IL-1beta production.	Ribose	102-110	NLR family, pyrin domain containing 3	Mus musculus	119-124
31737627-12	2019	These results strongly suggest that relatively long term administration of D-ribose induces NLRP3 inflammasome formation and activation in podocytes via AGEs/RAGE signaling pathway, which may be one of important triggering mechanisms leading to diabetic nephropathy.	Ribose	75-83	NLR family, pyrin domain containing 3	Mus musculus	92-97
31737627-5	2019	Administration of D-ribose daily for 30 days was found to induce NLRP3 inflammasome formation in glomerular podocyte, as shown by increased co-localization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Ribose	18-26	NLR family, pyrin domain containing 3	Mus musculus	159-164
31369292-0	2019	Tamoxifen-induced, intestinal-specific deletion of Slc5a6 in adult mice leads to spontaneous inflammation: involvement of NF-kappaB, NLRP3, and gut microbiota.	Tamoxifen	0-9	NLR family, pyrin domain containing 3	Mus musculus	133-138
31413130-8	2019	Evans blue intensities in WT mouse tissues are significantly higher than in NLRP3-/- mouse tissues, demonstrating an essential role of NLRP3 in M-induced vascular leakages in mice.	Evans Blue	0-10	NLR family, pyrin domain containing 3	Mus musculus	135-140
31600901-6	2019	Our data shows that the Dox treatment significantly increased expression of inflammasome markers (TLR4 and NLRP3), pyroptotic markers (caspase-1, IL1-beta, and IL-18), cell signaling proteins (MyD88, p-P38, and p-JNK), pro-inflammatory M1 macrophages, and TNF-alpha cytokine.	Doxorubicin	24-27	NLR family, pyrin domain containing 3	Mus musculus	107-112
31680990-7	2019	The resulting peroxynitrite generation led to increased oxidative stress that triggered inflammation as shown by increased NLRP-3 inflammasome activation and increased cell death.	Peroxynitrous Acid	14-27	NLR family, pyrin domain containing 3	Mus musculus	123-129
30869745-0	2019	Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin.	Melatonin	138-147	NLR family, pyrin domain containing 3	Mus musculus	8-13
30869745-9	2019	The fewer sarcopenic changes as well as the highly detectable prophylactic effects of melatonin treatment reported here in the muscle of NLRP3-knockout mice comparing with that previously detected in wild-type mice, confirming NLRP3 inflammasome implication in muscular aging and sarcopenia onset and progression.	Melatonin	86-95	NLR family, pyrin domain containing 3	Mus musculus	137-142
30869745-9	2019	The fewer sarcopenic changes as well as the highly detectable prophylactic effects of melatonin treatment reported here in the muscle of NLRP3-knockout mice comparing with that previously detected in wild-type mice, confirming NLRP3 inflammasome implication in muscular aging and sarcopenia onset and progression.	Melatonin	86-95	NLR family, pyrin domain containing 3	Mus musculus	227-232
31369292-9	2019	Overall, these findings support our conclusion that the biotin transport pathway plays an important role in the maintenance of intestinal homeostasis, and that NF-kappaB and the NLRP3 inflammasome, as well as gut microbiota, drive the development of intestinal inflammation when SMVT is absent.NEW & NOTEWORTHY This study demonstrates that deletion of the intestinal biotin uptake system in adult mice leads to the development of spontaneous gut inflammation and that luminal microbiota plays a role in its development.	Biotin	367-373	NLR family, pyrin domain containing 3	Mus musculus	178-183
31369292-9	2019	Overall, these findings support our conclusion that the biotin transport pathway plays an important role in the maintenance of intestinal homeostasis, and that NF-kappaB and the NLRP3 inflammasome, as well as gut microbiota, drive the development of intestinal inflammation when SMVT is absent.NEW & NOTEWORTHY This study demonstrates that deletion of the intestinal biotin uptake system in adult mice leads to the development of spontaneous gut inflammation and that luminal microbiota plays a role in its development.	Phenobarbital	468-475	NLR family, pyrin domain containing 3	Mus musculus	178-183
30632647-0	2019	GEN-27 exhibits anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-kappaB pathway.	gen-27	0-6	NLR family, pyrin domain containing 3	Mus musculus	75-80
31271646-8	2019	KEY RESULTS: Treatment of macrophages with probenecid or AZ11645373 in vitro diminished NLRP3 inflammasome-dependent IL-1beta secretion.	AZ 11645373	57-67	NLR family, pyrin domain containing 3	Mus musculus	88-93
31175486-0	2019	ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages.	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	57-62
31175486-1	2019	ATP acts as a canonical activator to induce NLRP3 (NOD-like receptor family, pyrin domain containing 3) inflammasome activation in macrophages, leading to caspase-1/gasdermin D (GSDMD)-mediated pyroptosis.	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	44-49
31175486-9	2019	Collectively, our results indicate that ATP induces pyroptosis in macrophages through the caspase-3/GSDME axis when the canonical NLRP3 pathway is blocked, suggestive of an alternative mechanism for combating against pathogen evasion.	Adenosine Triphosphate	40-43	NLR family, pyrin domain containing 3	Mus musculus	130-135
31395340-5	2019	Moreover, we confirmed that NF-kappaB/NLRP3 pathway was involved in the therapeutic effect of Verapamil against LPS-induced injury in vivo and in vitro.	Verapamil	94-103	NLR family, pyrin domain containing 3	Mus musculus	38-43
31271646-8	2019	KEY RESULTS: Treatment of macrophages with probenecid or AZ11645373 in vitro diminished NLRP3 inflammasome-dependent IL-1beta secretion.	Probenecid	43-53	NLR family, pyrin domain containing 3	Mus musculus	88-93
30632647-7	2019	Mechanistically, GEN-27 abated LPS-induced reactive oxygen species production, as well as mitigated LPS-induced increase of caspase 1 activity and the protein levels of NOD-like receptor 3 (NLRP3), anti-apoptosis-associated speck-like protein-containing a CRAD (ASC), and caspase 1 in RAW264.7 cells in a dose-dependent manner.	gen-27	17-23	NLR family, pyrin domain containing 3	Mus musculus	169-188
30632647-7	2019	Mechanistically, GEN-27 abated LPS-induced reactive oxygen species production, as well as mitigated LPS-induced increase of caspase 1 activity and the protein levels of NOD-like receptor 3 (NLRP3), anti-apoptosis-associated speck-like protein-containing a CRAD (ASC), and caspase 1 in RAW264.7 cells in a dose-dependent manner.	gen-27	17-23	NLR family, pyrin domain containing 3	Mus musculus	190-195
30632647-8	2019	Similarly, GEN-27 dose-dependently weakened adenosine triphosphate-induced NLRP3 and IL-1beta in RAW264.7 cells.	gen-27	11-17	NLR family, pyrin domain containing 3	Mus musculus	75-80
31694081-0	2019	PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages.	Fatty Acids	53-63	NLR family, pyrin domain containing 3	Mus musculus	72-77
30632647-8	2019	Similarly, GEN-27 dose-dependently weakened adenosine triphosphate-induced NLRP3 and IL-1beta in RAW264.7 cells.	Adenosine Triphosphate	44-66	NLR family, pyrin domain containing 3	Mus musculus	75-80
30632647-10	2019	In summary, these results revealed that GEN-27 exhibited anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-kappaB pathway, suggesting that GEN-27 may be served as a promising therapeutic agent for the prevention and therapy of inflammatory-associated diseases.	gen-27	40-46	NLR family, pyrin domain containing 3	Mus musculus	116-121
30632647-10	2019	In summary, these results revealed that GEN-27 exhibited anti-inflammatory effects by suppressing the activation of NLRP3 inflammasome and NF-kappaB pathway, suggesting that GEN-27 may be served as a promising therapeutic agent for the prevention and therapy of inflammatory-associated diseases.	gen-27	174-180	NLR family, pyrin domain containing 3	Mus musculus	116-121
31694081-12	2019	Furthermore, genetic inhibition of DGAT1 suppressed fatty acid-induced NLRP3 inflammasome activation.	Fatty Acids	52-62	NLR family, pyrin domain containing 3	Mus musculus	71-76
31694081-13	2019	CONCLUSION: Our results suggest that PF-04620110 suppresses fatty acid-induced NLRP3 inflammasome activation.	Fatty Acids	60-70	NLR family, pyrin domain containing 3	Mus musculus	79-84
31577945-0	2019	Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.	Glutathione	0-11	NLR family, pyrin domain containing 3	Mus musculus	42-47
31577945-2	2019	Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome.	Glutathione	22-33	NLR family, pyrin domain containing 3	Mus musculus	132-137
31694081-8	2019	RESULTS: Here we show that PF-04620110 suppressed fatty acid-induced nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR), pyrin-domain-containing 3 (NLRP3) inflammasome activation in macrophages.	Fatty Acids	50-60	NLR family, pyrin domain containing 3	Mus musculus	170-175
31276670-0	2019	NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.	Cisplatin	41-50	NLR family, pyrin domain containing 3	Mus musculus	0-5
31276670-2	2019	Here, we investigated whether a specific inhibitor of NLRP3 inflammasome, MCC950, can attenuate cisplatin-induced renal fibrosis.	Cisplatin	96-105	NLR family, pyrin domain containing 3	Mus musculus	54-59
31319131-6	2019	We found that the metformin pretreatment alleviated the lung injury and decreased the levels of TNF-a, IL-1beta and IL-6 in the bronchoalveolar lavage fluid (BALF) and in lung tissues, as well as the levels of NLRP3, NLRC4 and cleaved caspase-1 associated with LPS-induced ALI in old mice.	Metformin	18-27	NLR family, pyrin domain containing 3	Mus musculus	210-215
31276670-6	2019	NLRP3-/- mice were used to confirm the role of NLRP3 inflammasome in cisplatin-induced renal fibrosis.	Cisplatin	69-78	NLR family, pyrin domain containing 3	Mus musculus	47-52
31276670-8	2019	In multiple-cisplatin-induced murine model, renal fibrosis was accompanied by the activation of NLRP3 inflammasome.	Cisplatin	12-21	NLR family, pyrin domain containing 3	Mus musculus	96-101
31276670-9	2019	MCC950, the specific inhibitor of NLRP3 inflammasome, reduced cisplatin-induced renal dysfunction, tubular damage, interstitial collagen deposit, and the expression of profibrotic parameters.	Cisplatin	62-71	NLR family, pyrin domain containing 3	Mus musculus	34-39
31276670-10	2019	NLRP3 inhibition might protect against cisplatin-induced renal fibrosis through the alleviation of oxidative stress and inflammation.	Cisplatin	39-48	NLR family, pyrin domain containing 3	Mus musculus	0-5
31276670-11	2019	Furthermore, inhibition of NLRP3 inflammasome activation by deleting NLRP3 gene halted the progression of cisplatin-induced renal fibrosis.	Cisplatin	106-115	NLR family, pyrin domain containing 3	Mus musculus	27-32
31276670-11	2019	Furthermore, inhibition of NLRP3 inflammasome activation by deleting NLRP3 gene halted the progression of cisplatin-induced renal fibrosis.	Cisplatin	106-115	NLR family, pyrin domain containing 3	Mus musculus	69-74
31276670-12	2019	CONCLUSION: Inhibition of NLRP3 inflammasome attenuates renal fibrosis due to repeated cisplatin injections, and might be identified as a potential target for attenuating cisplatin-induced chronic kidney disease.	Cisplatin	87-96	NLR family, pyrin domain containing 3	Mus musculus	26-31
31276670-12	2019	CONCLUSION: Inhibition of NLRP3 inflammasome attenuates renal fibrosis due to repeated cisplatin injections, and might be identified as a potential target for attenuating cisplatin-induced chronic kidney disease.	Cisplatin	171-180	NLR family, pyrin domain containing 3	Mus musculus	26-31
31352325-5	2019	After the administration of TP at the dose of 600 mug/kg for 12 h or 24 h, we examined the serum biochemical parameters, liver histopathological changes, the expression of liver inflammatory factors, and the activation of NLRP3 inflammasome.	triptolide	28-30	NLR family, pyrin domain containing 3	Mus musculus	222-227
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	NLR family, pyrin domain containing 3	Mus musculus	156-175
31549524-7	2019	Kaempferol reduces pyroptosis by suppressing the expression and activity of caspase-1, increasing the protein expression of Toll-like receptor 4 (TLR4) and NOD-like receptor 3 (NLRP3), and inhibition of the decomposition of gasdermin D (GSDMD).	Kaempferols	0-10	NLR family, pyrin domain containing 3	Mus musculus	177-182
31401385-7	2019	In addition, Astragaloside IV significantly inhibited NFkappaB mediated NLRP3 inflammasome activation and activated Nrf2 both in vivo and in vitro.	astragaloside	13-26	NLR family, pyrin domain containing 3	Mus musculus	72-77
31352325-7	2019	Further results implied that the activation of TLR4-Myd88-NF-kappaB pathway and oxidative stress induced by a single dose of TP (600 mug/kg) might participate in the activation of NLRP3 inflammasome.	triptolide	125-127	NLR family, pyrin domain containing 3	Mus musculus	180-185
31583056-0	2019	Gamma-tocopherol ameliorates hyperglycemia-induced hepatic inflammation associated with NLRP3 inflammasome in alloxan-induced diabetic mice.	gamma-Tocopherol	0-16	NLR family, pyrin domain containing 3	Mus musculus	88-93
31401385-9	2019	These findings demonstrate that Astragaloside IV protects dopaminergic neuron from neuroinflammation and oxidative stress which are largely dependent upon activation of the Nrf2 pathways and suppression of NFkappaB/NLRP3 inflammasome signaling pathway.	astragaloside	32-45	NLR family, pyrin domain containing 3	Mus musculus	215-220
31432098-0	2019	Hydrogen alleviates mitochondrial dysfunction and organ damage via autophagy-mediated NLRP3 inflammasome inactivation in sepsis.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	86-91
31432098-8	2019	The results demonstrated that LPS and ATP led to NLRP3 inflammasome pathway activation, excessive cytokine release, mitochondrial dysfunction and the activation of autophagy.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	49-54
31432098-10	2019	H2 treatment ameliorated vital organ damage, the inflammatory response, mitochondrial dysfunction and NLRP3 pathway activation, and promoted autophagy in macrophages induced by LPS and in CLP mice.	Deuterium	0-2	NLR family, pyrin domain containing 3	Mus musculus	102-107
31432098-11	2019	However, the inhibitor of autophagy and the inducer of NLRP3 reversed the protective effect of H2 against organ damage, the inflammatory response and mitochondrial dysfunction in vivo and in vitro.	Deuterium	95-97	NLR family, pyrin domain containing 3	Mus musculus	55-60
31432098-12	2019	Collectively, the results demonstrated that H2 alleviated mitochondrial dysfunction and cytokine release via autophagy-mediated NLRP3 inflammasome inactivation.	Deuterium	44-46	NLR family, pyrin domain containing 3	Mus musculus	128-133
31296606-2	2019	Established contributors to oxalate crystal-induced renal necroinflammation include the NACHT, LRR and PYD domains-containing protein-3 (NLRP3) inflammasome and mixed lineage kinase domain-like (MLKL) protein-dependent tubule necroptosis.	Oxalates	28-35	NLR family, pyrin domain containing 3	Mus musculus	88-135
31296606-2	2019	Established contributors to oxalate crystal-induced renal necroinflammation include the NACHT, LRR and PYD domains-containing protein-3 (NLRP3) inflammasome and mixed lineage kinase domain-like (MLKL) protein-dependent tubule necroptosis.	Oxalates	28-35	NLR family, pyrin domain containing 3	Mus musculus	137-142
31583056-3	2019	In this study, we investigated the hypothesis that gamma-tocopherol (GT) supplementation ameliorates NLRP3 inflammasome associated hepatic inflammation in diabetes.	gamma-Tocopherol	51-67	NLR family, pyrin domain containing 3	Mus musculus	101-106
31570110-10	2019	Confocal analysis of Iba1-stained retinal flatmounts and qPCR demonstrated that ONL1204 also abrogated microglia activation and inhibited the induction of multiple genes implicated in glaucoma, including cytokines and chemokines (GFAP, Caspase-8, TNFalpha, IL-1beta, IL-6, IL-18, MIP-1alpha, MIP-1beta, MIP-2, MCPI, and IP10), components of the complement cascade (C3, C1Q), Toll-like receptor pathway (TLR4), and inflammasome pathway (NLRP3).	hydroxylysyl-5-oxonorleucine	80-87	NLR family, pyrin domain containing 3	Mus musculus	436-441
31302317-0	2019	Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation.	obovatol	0-8	NLR family, pyrin domain containing 3	Mus musculus	18-23
31302317-7	2019	RESULTS: Obovatol inhibited NLRP3, AIM2, and non-canonical inflammasomes through inhibition of Asc pyroptosome formation and mitochondrial ROS generation.	obovatol	9-17	NLR family, pyrin domain containing 3	Mus musculus	28-33
31302317-10	2019	CONCLUSION: Obovatol is suggested as an inhibitor of NLRP3, AIM2, and non-canonical inflammasomes.	obovatol	12-20	NLR family, pyrin domain containing 3	Mus musculus	53-58
31340160-8	2019	In addition, 5 mg/kg andrographolide treatment also decreased the expression of pro-inflammatory mediators and cytokines (NO, COX-2, iNOS, IL-1beta, IL-6 and TNF-alpha), NF-kappaB signaling (p-p65, p-IkappaBalpha) and NLRP3 inflammasome assembly (NLRP3, ASC and caspase-1) in the prefrontal cortex.	andrographolide	21-36	NLR family, pyrin domain containing 3	Mus musculus	218-223
31558153-0	2019	Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice.	astragaloside	0-13	NLR family, pyrin domain containing 3	Mus musculus	72-77
31525186-4	2019	However, drug discovery efforts have been constrained by the lack of insight into the molecular target and mechanism by which these CRIDs inhibit the NLRP3 inflammasome pathway.	crids	132-137	NLR family, pyrin domain containing 3	Mus musculus	150-155
31561220-0	2019	The role of NLRP3 in traumatic brain injury and its regulation by pioglitazone.	pioglitazone	66-78	NLR family, pyrin domain containing 3	Mus musculus	12-17
31561220-3	2019	The nucleotide-binding domain and leucine-rich repeat (NLR) family pyrin domain-containing 3 protein (NLRP3) is a key component of secondary injury.	leucylleucine	34-41	NLR family, pyrin domain containing 3	Mus musculus	102-107
31561220-4	2019	Pioglitazone regulates NLRP3 and other inflammatory cytokines.	pioglitazone	0-12	NLR family, pyrin domain containing 3	Mus musculus	23-28
31561220-11	2019	In Western blot, the expression of inflammasomes was higher after TBI in the sham group, but the expression of interleukin-1beta, caspase-1, and NLRP3 was decreased significantly following treatment with pioglitazone.	pioglitazone	204-216	NLR family, pyrin domain containing 3	Mus musculus	145-150
31561220-15	2019	Interestingly, pioglitazone reduced cerebral edema and immune response after TBI by downregulating the effects of NLRP3.	pioglitazone	15-27	NLR family, pyrin domain containing 3	Mus musculus	114-119
31616405-4	2019	Here we tested the hypothesis that DHA suppresses cSiO2-induced NLRP3 inflammasome activation, IL-1 cytokine release, and cell death in the macrophage.	Docosahexaenoic Acids	35-38	NLR family, pyrin domain containing 3	Mus musculus	64-69
31616405-4	2019	Here we tested the hypothesis that DHA suppresses cSiO2-induced NLRP3 inflammasome activation, IL-1 cytokine release, and cell death in the macrophage.	Silicon	50-55	NLR family, pyrin domain containing 3	Mus musculus	64-69
31616405-12	2019	DHA"s suppressive effects were linked to inhibition of LPS-induced Nlrp3, Il1b, and Il1a transcription, potentially through the activation of PPARgamma.	Docosahexaenoic Acids	0-3	NLR family, pyrin domain containing 3	Mus musculus	67-72
31340160-8	2019	In addition, 5 mg/kg andrographolide treatment also decreased the expression of pro-inflammatory mediators and cytokines (NO, COX-2, iNOS, IL-1beta, IL-6 and TNF-alpha), NF-kappaB signaling (p-p65, p-IkappaBalpha) and NLRP3 inflammasome assembly (NLRP3, ASC and caspase-1) in the prefrontal cortex.	andrographolide	21-36	NLR family, pyrin domain containing 3	Mus musculus	247-252
31700865-0	2019	The SGLT2 inhibitor dapagliflozin attenuates the activity of ROS-NLRP3 inflammasome axis in steatohepatitis with diabetes mellitus.	dapagliflozin	20-33	NLR family, pyrin domain containing 3	Mus musculus	65-70
31552054-15	2019	Delayed administration of ibrutinib and acalabrutinib attenuated the decline of EF, FS, and FAC caused by CLP and also reduced the activation of BTK, NF-kappaB, and NLRP3 inflammasome.	ibrutinib	26-35	NLR family, pyrin domain containing 3	Mus musculus	165-170
31552054-15	2019	Delayed administration of ibrutinib and acalabrutinib attenuated the decline of EF, FS, and FAC caused by CLP and also reduced the activation of BTK, NF-kappaB, and NLRP3 inflammasome.	acalabrutinib	40-53	NLR family, pyrin domain containing 3	Mus musculus	165-170
31572210-6	2019	B-R3D increased the protein expression of NLRP3 inflammasome components ASC, caspase-1, and interleukin-1beta in the obstructed kidneys, which was markedly prevented by aliskiren.	aliskiren	169-178	NLR family, pyrin domain containing 3	Mus musculus	42-47
31572210-8	2019	These results indicate that the renin inhibitor aliskiren increases water channel AQP2 expression at least partially by suppressing NLRP3 inflammasome activation in the obstructed kidneys of mice with BUO and BUO release.	aliskiren	48-57	NLR family, pyrin domain containing 3	Mus musculus	132-137
31700865-9	2019	Further mechanistic investigations indicated that the protection of DAPA on diabetic liver injury was associated with the suppressed production of hepatic reactive oxygen species (ROS) and malondialdehyde (MDA) and the inhibited activation of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome.	dapagliflozin	68-72	NLR family, pyrin domain containing 3	Mus musculus	295-300
31203155-0	2019	Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.	cycloastragenol	70-85	NLR family, pyrin domain containing 3	Mus musculus	14-19
30523572-0	2019	Selenium Attenuates Staphylococcus aureus Mastitis in Mice by Inhibiting the Activation of the NALP3 Inflammasome and NF-kappaB/MAPK Pathway.	Selenium	0-8	NLR family, pyrin domain containing 3	Mus musculus	95-100
30523572-2	2019	In this study, we explored whether selenium can inhibit the activation of the NALP3 inflammasome and NF-kappaB/MAPK pathway to achieve anti-inflammatory effects.	Selenium	35-43	NLR family, pyrin domain containing 3	Mus musculus	78-83
30523572-6	2019	Therefore, this study revealed that selenium can attenuate S. aureus mastitis by inhibiting the activation of the NALP3 inflammasome and NF-kappaB/MAPK pathway.	Selenium	36-44	NLR family, pyrin domain containing 3	Mus musculus	114-119
31177914-7	2019	We also found that IRGM suppresses NLRP3-mediated exacerbated outcomes of dextran sodium sulfate (DSS)-induced colitis in a mouse model.	dextran sodium sulfate	74-96	NLR family, pyrin domain containing 3	Mus musculus	35-40
31177914-7	2019	We also found that IRGM suppresses NLRP3-mediated exacerbated outcomes of dextran sodium sulfate (DSS)-induced colitis in a mouse model.	dss	98-101	NLR family, pyrin domain containing 3	Mus musculus	35-40
31599445-5	2019	Cardiolipin is reported to be effective to trigger the activation of NLRP3 inflammasome through a ROS-independent signaling pathway.	ros	98-101	NLR family, pyrin domain containing 3	Mus musculus	69-74
31203155-0	2019	Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.	Imiquimod	117-126	NLR family, pyrin domain containing 3	Mus musculus	14-19
31203155-9	2019	Taken together, the results show that CAG selectively modulates macrophage function by inhibiting NLRP3 inflammasome-mediated pyroptosis to ameliorate IMQ-induced psoriasis-like skin inflammation in mice.	Imiquimod	151-154	NLR family, pyrin domain containing 3	Mus musculus	98-103
30945296-12	2019	Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7/NLRP3.	Metformin	77-86	NLR family, pyrin domain containing 3	Mus musculus	127-132
31069623-0	2019	FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation.	Fingolimod Hydrochloride	0-6	NLR family, pyrin domain containing 3	Mus musculus	64-69
31069623-0	2019	FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation.	mangion-purified polysaccharide (Candida albicans)	16-20	NLR family, pyrin domain containing 3	Mus musculus	64-69
31069623-9	2019	Moreover, in MPP+-treated BV-2 cells and primary microglia, FTY720 treatment significantly attenuated the increases in the phosphorylation of PI3K/AKT/GSK-3beta, reduced ROS generation and p65 activation, and also inhibited the activation of NLRP3 inflammasome and caspase-1.	mangion-purified polysaccharide (Candida albicans)	13-17	NLR family, pyrin domain containing 3	Mus musculus	242-247
31069623-9	2019	Moreover, in MPP+-treated BV-2 cells and primary microglia, FTY720 treatment significantly attenuated the increases in the phosphorylation of PI3K/AKT/GSK-3beta, reduced ROS generation and p65 activation, and also inhibited the activation of NLRP3 inflammasome and caspase-1.	Fingolimod Hydrochloride	60-66	NLR family, pyrin domain containing 3	Mus musculus	242-247
31069623-10	2019	In conclusion, FTY720 may reduce PD progression by inhibiting NLRP3 inflammasome activation via its effects on ROS generation and p65 activation in microglia.	ros	111-114	NLR family, pyrin domain containing 3	Mus musculus	62-67
30945296-14	2019	Metformin suppressed the inflammatory state by inhibiting Nek7 expression to decrease NLRP3 inflammasome activity.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	86-91
31069623-12	2019	Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage.	Fingolimod Hydrochloride	19-25	NLR family, pyrin domain containing 3	Mus musculus	177-182
31336157-11	2019	Coptisine not only prevented NLRP3 inflammasome assembly by affecting the binding between pro-caspase-1 and apoptosis-associated speck-like protein containing a CARD, but also inhibited inflammasome priming by decreasing NLRP3 expression through inactivation of the nuclear factor-kappaB pathway.	coptisine	0-9	NLR family, pyrin domain containing 3	Mus musculus	29-34
31152156-0	2019	Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress.	Flavonoids	0-9	NLR family, pyrin domain containing 3	Mus musculus	83-88
31152156-0	2019	Flavonoid VI-16 protects against DSS-induced colitis by inhibiting Txnip-dependent NLRP3 inflammasome activation in macrophages via reducing oxidative stress.	vi-16	10-15	NLR family, pyrin domain containing 3	Mus musculus	83-88
31152156-4	2019	Here we report that VI-16, a synthetic flavonoid compound, exerts potent anti-inflammatory effects on macrophages in DSS-induced colitis mice, which intervened in the activation of NLRP3 inflammasome without affecting intestinal epithelial cells.	vi-16	20-25	NLR family, pyrin domain containing 3	Mus musculus	181-186
31152156-5	2019	However, the protection of VI-16 against DSS-induced colitis was dependent on NLRP3 expression in hematopoietic cells.	vi-16	27-32	NLR family, pyrin domain containing 3	Mus musculus	78-83
31152156-7	2019	Further studies confirm that VI-16 inhibits the binding of Txnip to NLRP3 by reducing oxidative stress and ultimately inhibits NLRP3 inflammasome.	vi-16	29-34	NLR family, pyrin domain containing 3	Mus musculus	68-73
31152156-7	2019	Further studies confirm that VI-16 inhibits the binding of Txnip to NLRP3 by reducing oxidative stress and ultimately inhibits NLRP3 inflammasome.	vi-16	29-34	NLR family, pyrin domain containing 3	Mus musculus	127-132
31152156-8	2019	This demonstrates the ability of VI-16 to inhibit the NLRP3 inflammasome activation and its potential use in the treatment of inflammatory bowel disease.	vi-16	33-38	NLR family, pyrin domain containing 3	Mus musculus	54-59
31336157-11	2019	Coptisine not only prevented NLRP3 inflammasome assembly by affecting the binding between pro-caspase-1 and apoptosis-associated speck-like protein containing a CARD, but also inhibited inflammasome priming by decreasing NLRP3 expression through inactivation of the nuclear factor-kappaB pathway.	coptisine	0-9	NLR family, pyrin domain containing 3	Mus musculus	221-226
31336157-12	2019	Moreover, coptisine prevented LPS-mediated IL-1beta production and MSU-mediated mice paw edema by blocking NLRP3 inflammasome activation in vivo.	coptisine	10-19	NLR family, pyrin domain containing 3	Mus musculus	107-112
31336157-13	2019	Coptisine blocks NLRP3 inflammasome activation by inhibiting caspase-1 and may be useful for treating NLRP3 inflammasome-involved gouty arthritis.	coptisine	0-9	NLR family, pyrin domain containing 3	Mus musculus	17-22
31336157-13	2019	Coptisine blocks NLRP3 inflammasome activation by inhibiting caspase-1 and may be useful for treating NLRP3 inflammasome-involved gouty arthritis.	coptisine	0-9	NLR family, pyrin domain containing 3	Mus musculus	102-107
31233226-16	2019	CONCLUSIONS: This study indicated that alcohol could aggravate the severity of prostatic inflammation in EAP model though activating the NLRP3 inflammasome.	Alcohols	39-46	NLR family, pyrin domain containing 3	Mus musculus	137-142
31359520-7	2019	After ACP intervention, the neuroethology of mice was significantly improved, as demonstrated by the elevated levels of dopamine in the striatum and the decreased expression of dopamine in the striatum in NLRP3 inflammasome.	Dopamine	177-185	NLR family, pyrin domain containing 3	Mus musculus	205-210
31359520-7	2019	After ACP intervention, the neuroethology of mice was significantly improved, as demonstrated by the elevated levels of dopamine in the striatum and the decreased expression of dopamine in the striatum in NLRP3 inflammasome.	acp	6-9	NLR family, pyrin domain containing 3	Mus musculus	205-210
31318658-7	2019	Foxp1 was further identified as a gatekeeper of vessel inflammation by direct regulation of endothelial inflammasome components, including Nlrp3 (NLR [nucleotide-binding and leucine-rich repeat immune receptors] family pyrin domain containing 3), caspase-1, and IL (interleukin)-1beta.	Leucine	174-181	NLR family, pyrin domain containing 3	Mus musculus	139-144
31555089-3	2019	The nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome, has been shown to be involved in TBI.	leucylleucine	47-54	NLR family, pyrin domain containing 3	Mus musculus	98-103
32305963-0	2019	H 2S protects against diabetes-accelerated atherosclerosis by preventing the activation of NLRP3 inflammasome.	Deuterium	0-4	NLR family, pyrin domain containing 3	Mus musculus	91-96
32305963-5	2019	Mechanically, GYY4137 suppressed the activation of pyrin domain containing protein 3 (NLRP3) inflammasome in diabetes-accelerated atherosclerosis conditions.	GYY 4137	14-21	NLR family, pyrin domain containing 3	Mus musculus	86-91
32305963-6	2019	Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and oxLDL could be reversed, indicating that H 2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome.	Glucose	72-79	NLR family, pyrin domain containing 3	Mus musculus	18-23
32305963-6	2019	Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and oxLDL could be reversed, indicating that H 2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome.	Glucose	72-79	NLR family, pyrin domain containing 3	Mus musculus	186-191
32305963-6	2019	Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and oxLDL could be reversed, indicating that H 2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome.	Deuterium	125-129	NLR family, pyrin domain containing 3	Mus musculus	18-23
32305963-6	2019	Upon knockdown of NLRP3, the increase of ICAM1 and VCAM1 caused by high glucose and oxLDL could be reversed, indicating that H 2S protected the endothelium by inhibiting the activity of NLRP3 inflammasome.	Deuterium	125-129	NLR family, pyrin domain containing 3	Mus musculus	186-191
31555089-3	2019	The nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome, has been shown to be involved in TBI.	MRT67307	71-76	NLR family, pyrin domain containing 3	Mus musculus	98-103
31555089-14	2019	Furthermore, NEK7 knock-down suppressed NLRP3 inflammasome activation and pyroptosis, which were triggered by K+ efflux, and the LPS + ATP-triggered NEK7-NLRP3 complex was reversed in primary cortical neurons placed in 50 mM K+ medium.	Adenosine Triphosphate	135-138	NLR family, pyrin domain containing 3	Mus musculus	40-45
31555089-14	2019	Furthermore, NEK7 knock-down suppressed NLRP3 inflammasome activation and pyroptosis, which were triggered by K+ efflux, and the LPS + ATP-triggered NEK7-NLRP3 complex was reversed in primary cortical neurons placed in 50 mM K+ medium.	Adenosine Triphosphate	135-138	NLR family, pyrin domain containing 3	Mus musculus	154-159
31439031-3	2019	Meanwhile, transplantation of the NLRP3 KO microbiota alleviated the CUS-induced depressive-like behaviors.	cus	69-72	NLR family, pyrin domain containing 3	Mus musculus	34-39
31455356-8	2019	Curcumin administration protected THP-1 and RAW264.7 cells from MSU induced mitochondrial damage through preventing mitochondrial membrane potential reduction, decreasing mitochondria ROS, and then inhibited the activity of NLRP3 inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	224-229
31455356-11	2019	CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	224-229
31455356-11	2019	CONCLUSION: Curcumin administration effectively alleviated MSU-induced inflammation by suppressing the degradation of IkappaBalpha, the activation NF-kappaB signaling pathway, the damage of mitochondria, and the activity of NLRP3 inflammasome.	Uric Acid	59-62	NLR family, pyrin domain containing 3	Mus musculus	224-229
31429763-2	2019	Here we postulated that high-salt-induced NFAT5 controls the inflammasome activation by directly regulating NLRP3, which mediates the expression of inflammatory- and adhesion-related genes in vascular endothelium, resulting in the formation of atherosclerosis.	Salts	29-33	NLR family, pyrin domain containing 3	Mus musculus	108-113
31244050-6	2019	Overall findings demonstrated that OC-rich EVOO restored the BBB function and reduced AD-associated pathology by reducing neuroinflammation through inhibition of NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome and inducing autophagy through activation of AMP-activated protein kinase (AMPK)/Unc-51-like autophagy activating kinase 1 (ULK1) pathway.	evoo	43-47	NLR family, pyrin domain containing 3	Mus musculus	211-216
31439870-5	2019	NLRP3 inflammasome was activated by ATP in bone marrow-derived primary mouse macrophages.	Adenosine Triphosphate	36-39	NLR family, pyrin domain containing 3	Mus musculus	0-5
31439870-9	2019	In addition, treatment with celastrol, an inhibitor of NLRP3 inflammasome, reduced the potency of macrophages to stimulate migration and invasion of melanoma cells.	celastrol	28-37	NLR family, pyrin domain containing 3	Mus musculus	55-60
31531121-0	2019	Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis.	polycoride	33-43	NLR family, pyrin domain containing 3	Mus musculus	60-65
31531121-0	2019	Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis.	Reactive Oxygen Species	56-59	NLR family, pyrin domain containing 3	Mus musculus	60-65
31531121-1	2019	Objective: To explore the effect of Tripterygium wilfordii polycoride (TWP) on the NADPH oxidases (NOXs)-reactive oxygen species (ROS)-NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway and the possibility of using TWP to treat ulcerative colitis (UC).	N-hydroxy-4-[(1H-indol-1-yl)methyl]benzamide	71-74	NLR family, pyrin domain containing 3	Mus musculus	164-169
31531121-1	2019	Objective: To explore the effect of Tripterygium wilfordii polycoride (TWP) on the NADPH oxidases (NOXs)-reactive oxygen species (ROS)-NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway and the possibility of using TWP to treat ulcerative colitis (UC).	Reactive Oxygen Species	105-128	NLR family, pyrin domain containing 3	Mus musculus	164-169
31531121-1	2019	Objective: To explore the effect of Tripterygium wilfordii polycoride (TWP) on the NADPH oxidases (NOXs)-reactive oxygen species (ROS)-NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway and the possibility of using TWP to treat ulcerative colitis (UC).	Reactive Oxygen Species	130-133	NLR family, pyrin domain containing 3	Mus musculus	164-169
31531121-9	2019	Conclusion: TWP demonstrated anti-inflammatory effects on UC by decreasing the expression of proinflammatory factors in the NOXs-ROS-NLRP3 signaling pathway.	Reactive Oxygen Species	129-132	NLR family, pyrin domain containing 3	Mus musculus	133-138
31429763-6	2019	RESULTS: We first observe that high-salt intake promotes atherosclerosis formation in the aortas of ApoE-/- mice, through inducing the expression of NFAT5, NLRP3, and IL-1beta in endothelium.	Salts	36-40	NLR family, pyrin domain containing 3	Mus musculus	156-161
31429763-8	2019	Chromatin immunoprecipitation assay demonstrates that NFAT5 directly binds to the promoter regions of NLRP3 and IL-1beta in endothelial cells subjected to the high-salt environment.	Salts	164-168	NLR family, pyrin domain containing 3	Mus musculus	102-107
31388770-0	2019	DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome.	Linagliptin	20-31	NLR family, pyrin domain containing 3	Mus musculus	95-100
31292215-3	2019	In this study, we demonstrate that protein citrullination is common during pyroptotic cell death in macrophages and that inhibition of PAD enzyme activity by Cl-amidine, a pan-PAD inhibitor, blocks NLRP3 inflammasome assembly and proinflammatory IL-1beta release in macrophages.	N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide	158-168	NLR family, pyrin domain containing 3	Mus musculus	198-203
30728466-0	2019	NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	92-96	NLR family, pyrin domain containing 3	Mus musculus	0-5
31447572-0	2019	A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	27-33	NLR family, pyrin domain containing 3	Mus musculus	98-103
31447572-9	2019	Inhibition of the NLRP3 inflammasome with MCC950 reduced the production of active caspase-1 and active IL-1beta in db/db mice and HG-induced mesangial cells.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	42-48	NLR family, pyrin domain containing 3	Mus musculus	18-23
31447572-13	2019	MCC950 effectively ameliorated diabetic kidney injury by inhibiting NLRP3/caspase-1/IL-1beta pathway, which may be a potential therapeutic strategy to prevent the progression of DN.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	68-73
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	36-40	NLR family, pyrin domain containing 3	Mus musculus	260-287
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	36-40	NLR family, pyrin domain containing 3	Mus musculus	289-294
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	Phosphorus	37-38	NLR family, pyrin domain containing 3	Mus musculus	260-287
30728466-12	2019	Furthermore, the olfactory bulbs in MPTP/P-treated mice showed significantly increased levels of interleukin-1beta (IL-1beta), caspase-1, glial fibrillary acidic protein (GFAP), Toll receptor 4 (TLR4), phosphorylation of p65, as well as activated molecules of NOD-like receptor protein 3 (NLRP3) that were associated with neuroinflammation.	Phosphorus	37-38	NLR family, pyrin domain containing 3	Mus musculus	289-294
30728466-13	2019	Our results demonstrate that MPTP/P-caused olfactory bulb damage might be related to NLRP3-mediated inflammation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	29-33	NLR family, pyrin domain containing 3	Mus musculus	85-90
30728466-13	2019	Our results demonstrate that MPTP/P-caused olfactory bulb damage might be related to NLRP3-mediated inflammation.	Phosphorus	30-31	NLR family, pyrin domain containing 3	Mus musculus	85-90
31121485-0	2019	Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
31162673-10	2019	In addition, L6H21 treatment markedly inhibited EtOH + LPS-elevated hepatic protein levels of NLRP3, cleaved caspase-1, cleaved IL-1beta, and caspase-1-associated apoptosis.	(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one	13-18	NLR family, pyrin domain containing 3	Mus musculus	94-99
31162673-10	2019	In addition, L6H21 treatment markedly inhibited EtOH + LPS-elevated hepatic protein levels of NLRP3, cleaved caspase-1, cleaved IL-1beta, and caspase-1-associated apoptosis.	Ethanol	48-52	NLR family, pyrin domain containing 3	Mus musculus	94-99
31162673-11	2019	CONCLUSIONS: Our results demonstrate that L6H21 treatment inhibits EtOH + LPS-induced liver steatosis and injury through suppression of NLRP3 inflammasome activation.	(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one	42-47	NLR family, pyrin domain containing 3	Mus musculus	136-141
31167564-8	2019	Furthermore, Mark4 deficiency in primary murine bone marrow-derived macrophages prevented cholesterol crystal-induced NLRP3 inflammasome activation, as revealed by reduced caspase-1 activity together with reduced production of IL-1beta and IL-18.	Cholesterol	90-101	NLR family, pyrin domain containing 3	Mus musculus	118-123
31162673-0	2019	Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation.	Chalcone	0-8	NLR family, pyrin domain containing 3	Mus musculus	88-93
31162673-0	2019	Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation.	(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one	20-25	NLR family, pyrin domain containing 3	Mus musculus	88-93
30791224-10	2019	The Pim-1 inhibitor AZD1208 reduced the severity of proteinuria, glomerulonephritis, renal immune complex deposits, and serum anti-dsDNA antibody levels, concomitant with the suppression of NFATc1 expression and NLRP3 inflammasome activation, in diseased (NZB x NZW)F1 mice (each P &lt; 0.05 versus controls).	AZD1208	20-27	NLR family, pyrin domain containing 3	Mus musculus	212-217
31121485-6	2019	Bilirubin prior to LPS treatment decreased protein expressions of Nlrp3, pro-interleukin (IL)-1beta and mature IL-1beta in PMs, whereas bilirubin post LPS treatment showed no effects.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	66-71
31121485-7	2019	Bilirubin prior to LPS treatment dose-dependently repressed expressions of Nlrp3 and IL-1beta, and inhibited translocation of p-p65 to nucleus in Raw264.7 cells.	Bilirubin	0-9	NLR family, pyrin domain containing 3	Mus musculus	75-80
31121485-11	2019	In conclusion, bilirubin acted on inflammation and alleviated alum-induced peritonitis through inactivation of Nlrp3 inflammasome.	Bilirubin	15-24	NLR family, pyrin domain containing 3	Mus musculus	111-116
30847744-0	2019	Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling.	sinomenine	0-10	NLR family, pyrin domain containing 3	Mus musculus	70-75
31215797-0	2019	Resveratrol Suppresses Abeta-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	81-86
31215797-0	2019	Resveratrol Suppresses Abeta-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway.	UNII-042A8N37WH	23-28	NLR family, pyrin domain containing 3	Mus musculus	81-86
31215797-7	2019	We conclude that resveratrol protects microglia from Abeta-stimulated inflammation by suppressing the inflammatory response, at least in part by inhibiting the TXNIP/TRX/NLRP3 signaling pathway.	Resveratrol	17-28	NLR family, pyrin domain containing 3	Mus musculus	170-175
30847744-3	2019	In the present study, the protective effect of SIN on ACLT-induced articular cartilage degeneration and IL-1beta-induced chondrocyte apoptosis miR-223-3p/NLRP3 signaling regulation was investigated.	sinomenine	47-50	NLR family, pyrin domain containing 3	Mus musculus	154-159
30887396-0	2019	Dihydromyricetin Alleviates Sepsis-Induced Acute Lung Injury through Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis in Mice Model.	dihydromyricetin	0-16	NLR family, pyrin domain containing 3	Mus musculus	80-85
30887396-2	2019	Dihydromyricetin (DHM) has been reported to exert anti-inflammatory effects by inhibiting NLRP3 inflammasome activation in vascular endothelial cells.	dihydromyricetin	0-16	NLR family, pyrin domain containing 3	Mus musculus	90-95
30887396-2	2019	Dihydromyricetin (DHM) has been reported to exert anti-inflammatory effects by inhibiting NLRP3 inflammasome activation in vascular endothelial cells.	dihydromyricetin	18-21	NLR family, pyrin domain containing 3	Mus musculus	90-95
30887396-9	2019	DHM treatment significantly inhibited the CLP-induced NLRP3 inflammasome pathway (NLRP3, ASC, caspase-1, gasdermin D (Gsdmd), IL-1beta, and IL-18).	dihydromyricetin	0-3	NLR family, pyrin domain containing 3	Mus musculus	54-59
30887396-9	2019	DHM treatment significantly inhibited the CLP-induced NLRP3 inflammasome pathway (NLRP3, ASC, caspase-1, gasdermin D (Gsdmd), IL-1beta, and IL-18).	dihydromyricetin	0-3	NLR family, pyrin domain containing 3	Mus musculus	82-87
30802544-4	2019	The functional S1PR1 antagonist FTY720 blocked NLRP3 activation and IL-1beta production.	Fingolimod Hydrochloride	32-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
30938884-10	2019	When we knocked down miR-181a and then treated cells with U0126 before ox-LDL stimulation, we found that U0126 reversed the increased activation of the MEK/ERK/NF-kappaB pathway and upregulation of NLRP3 inflammasome-related proteins (NLRP3, caspase-1, IL-18, IL-1beta) that resulted from miR-181a knockdown.	U 0126	58-63	NLR family, pyrin domain containing 3	Mus musculus	198-203
30938884-10	2019	When we knocked down miR-181a and then treated cells with U0126 before ox-LDL stimulation, we found that U0126 reversed the increased activation of the MEK/ERK/NF-kappaB pathway and upregulation of NLRP3 inflammasome-related proteins (NLRP3, caspase-1, IL-18, IL-1beta) that resulted from miR-181a knockdown.	U 0126	58-63	NLR family, pyrin domain containing 3	Mus musculus	235-240
30938884-10	2019	When we knocked down miR-181a and then treated cells with U0126 before ox-LDL stimulation, we found that U0126 reversed the increased activation of the MEK/ERK/NF-kappaB pathway and upregulation of NLRP3 inflammasome-related proteins (NLRP3, caspase-1, IL-18, IL-1beta) that resulted from miR-181a knockdown.	U 0126	105-110	NLR family, pyrin domain containing 3	Mus musculus	198-203
30938884-10	2019	When we knocked down miR-181a and then treated cells with U0126 before ox-LDL stimulation, we found that U0126 reversed the increased activation of the MEK/ERK/NF-kappaB pathway and upregulation of NLRP3 inflammasome-related proteins (NLRP3, caspase-1, IL-18, IL-1beta) that resulted from miR-181a knockdown.	U 0126	105-110	NLR family, pyrin domain containing 3	Mus musculus	235-240
31153046-0	2019	Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation.	Carbon Monoxide	0-15	NLR family, pyrin domain containing 3	Mus musculus	128-133
31153046-11	2019	The results of this study suggested a protective role of CORM-2 in PM-induced lung inflammation by inhibiting the TLR2 and TLR4/ROS-NLRP3 inflammasome-CRP axial.	ros	128-131	NLR family, pyrin domain containing 3	Mus musculus	132-137
31153046-0	2019	Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation.	ros	124-127	NLR family, pyrin domain containing 3	Mus musculus	128-133
31255694-0	2019	Chaetocin attenuates gout in mice through inhibiting HIF-1alpha and NLRP3 inflammasome-dependent IL-1beta secretion in macrophages.	chaetocin	0-9	NLR family, pyrin domain containing 3	Mus musculus	68-73
31070765-0	2019	Blockade of the NLRP3/Caspase-1 Axis Ameliorates Airway Neutrophilic Inflammation in a Toluene Diisocyanate-Induced Murine Asthma Model.	Toluene 2,4-Diisocyanate	87-107	NLR family, pyrin domain containing 3	Mus musculus	16-21
31070765-2	2019	Yet, the role of NLRP3/caspase-1 in toluene diisocyanate (TDI)-induced asthma is still obscure.	Toluene 2,4-Diisocyanate	36-56	NLR family, pyrin domain containing 3	Mus musculus	17-22
31255694-4	2019	In the study, we found that chaetocin could decrease MSU induced IL-1beta secretion in bone marrow derived macrophages by several mechanisms, including inhibiting the activation of NLRP3 inflammasome.	chaetocin	28-37	NLR family, pyrin domain containing 3	Mus musculus	181-186
31255694-8	2019	In MSU-induced peritonitis model, the peritoneal macrophages of chaetocin-pretreated mice showed significantly decreased mRNA levels of HIF-1alpha and NLRP3 related genes.	chaetocin	64-73	NLR family, pyrin domain containing 3	Mus musculus	151-156
31187838-0	2019	Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation.	Polyphenols	10-21	NLR family, pyrin domain containing 3	Mus musculus	105-110
31417546-11	2019	The LMP-mediated microbial balance further enhanced caecal barrier function and shaped gut-pancreatic immune environment, as characterized by higher expression of tight junction proteins claudin-1, ZO-2 in caecum, increased Foxp3+ Treg population and decreased NLRP3 inflammasome activation in both caecum and pancreas.	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	4-7	NLR family, pyrin domain containing 3	Mus musculus	261-266
31417409-0	2019	Amentoflavone Affects Epileptogenesis and Exerts Neuroprotective Effects by Inhibiting NLRP3 Inflammasome.	amentoflavone	0-13	NLR family, pyrin domain containing 3	Mus musculus	87-92
31417409-8	2019	Amentoflavone also inhibited the activation of the NLRP3 inflammasome and decreased the levels of inflammatory cytokines in the hippocampus of PTZ-induced kindling mice.	amentoflavone	0-13	NLR family, pyrin domain containing 3	Mus musculus	51-56
31417409-9	2019	Additionally, amentoflavone could alleviate the LPS-induced inflammatory response by inhibiting the NLRP3 inflammasome in LPS-induced BV2 microglial cells.	amentoflavone	14-27	NLR family, pyrin domain containing 3	Mus musculus	100-105
31417409-10	2019	Our results indicated that amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting the NLRP3 inflammasome and, thus, mediating the inflammatory process in PTZ-induced kindling mice and LPS-induced BV2 microglial cells.	amentoflavone	27-40	NLR family, pyrin domain containing 3	Mus musculus	118-123
31417409-10	2019	Our results indicated that amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting the NLRP3 inflammasome and, thus, mediating the inflammatory process in PTZ-induced kindling mice and LPS-induced BV2 microglial cells.	Pentylenetetrazole	186-189	NLR family, pyrin domain containing 3	Mus musculus	118-123
31187838-8	2019	Furthermore, GTPs reduced LPS-induced hepatic NF-kappaB signaling and NLRP3 inflammasome activation.	gtps	13-17	NLR family, pyrin domain containing 3	Mus musculus	70-75
31316052-0	2019	Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome.	Propofol	0-8	NLR family, pyrin domain containing 3	Mus musculus	80-85
31187838-9	2019	GTPs exert protective effects against inflammatory liver injury by regulating NF-kappaB signaling and the NLRP3 inflammasome activation.	gtps	0-4	NLR family, pyrin domain containing 3	Mus musculus	106-111
31316052-13	2019	Our studies suggest, for the first time, that propofol-induced pyroptosis might be restricted to macrophage through an NLRP3/ASC/caspase-1 pathway, which provides potential targets for limiting adverse reactions during propofol application.	Propofol	46-54	NLR family, pyrin domain containing 3	Mus musculus	119-124
31316052-13	2019	Our studies suggest, for the first time, that propofol-induced pyroptosis might be restricted to macrophage through an NLRP3/ASC/caspase-1 pathway, which provides potential targets for limiting adverse reactions during propofol application.	Propofol	219-227	NLR family, pyrin domain containing 3	Mus musculus	119-124
31337751-0	2019	Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination.	Acetates	0-7	NLR family, pyrin domain containing 3	Mus musculus	81-86
31337751-6	2019	In addition, acetate activates soluble adenylyl cyclase (sAC), promotes NLRP3 inflammasome ubiquitination by PKA, and ultimately induces NLRP3 degradation through autophagy.	Acetates	13-20	NLR family, pyrin domain containing 3	Mus musculus	72-77
31337751-6	2019	In addition, acetate activates soluble adenylyl cyclase (sAC), promotes NLRP3 inflammasome ubiquitination by PKA, and ultimately induces NLRP3 degradation through autophagy.	Acetates	13-20	NLR family, pyrin domain containing 3	Mus musculus	137-142
31337751-7	2019	In vivo, acetate protects mice from NLRP3 inflammasome-dependent peritonitis and LPS-induced endotoxemia.	Acetates	9-16	NLR family, pyrin domain containing 3	Mus musculus	36-41
31337751-8	2019	Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.	Acetates	45-52	NLR family, pyrin domain containing 3	Mus musculus	67-72
31337751-8	2019	Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.	Acetates	45-52	NLR family, pyrin domain containing 3	Mus musculus	178-183
31337751-8	2019	Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.	Acetates	45-52	NLR family, pyrin domain containing 3	Mus musculus	178-183
31337751-8	2019	Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.	Acetates	224-231	NLR family, pyrin domain containing 3	Mus musculus	67-72
31316052-10	2019	Here, we show that propofol-induced mitochondrial reactive oxygen species (ROS) can trigger NLRP3 inflammasome activation.	Propofol	19-27	NLR family, pyrin domain containing 3	Mus musculus	92-97
31316052-10	2019	Here, we show that propofol-induced mitochondrial reactive oxygen species (ROS) can trigger NLRP3 inflammasome activation.	Reactive Oxygen Species	50-73	NLR family, pyrin domain containing 3	Mus musculus	92-97
31316052-10	2019	Here, we show that propofol-induced mitochondrial reactive oxygen species (ROS) can trigger NLRP3 inflammasome activation.	Reactive Oxygen Species	75-78	NLR family, pyrin domain containing 3	Mus musculus	92-97
31311094-0	2019	NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis.	Melatonin	33-42	NLR family, pyrin domain containing 3	Mus musculus	0-5
31311094-7	2019	Our results showed that melatonin attenuates pristane-induced LN through restoring of morphology and attenuation of oxidative stress and inflammation through a pathway that inhibited activation of NLRP3 inflammasome signaling.	Melatonin	24-33	NLR family, pyrin domain containing 3	Mus musculus	197-202
31311094-0	2019	NLRP3 Inflammasome Modulation by Melatonin Supplementation in Chronic Pristane-Induced Lupus Nephritis.	pristane	70-78	NLR family, pyrin domain containing 3	Mus musculus	0-5
31311094-7	2019	Our results showed that melatonin attenuates pristane-induced LN through restoring of morphology and attenuation of oxidative stress and inflammation through a pathway that inhibited activation of NLRP3 inflammasome signaling.	pristane	45-53	NLR family, pyrin domain containing 3	Mus musculus	197-202
31354519-0	2019	Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome.	trimethyloxamine	0-22	NLR family, pyrin domain containing 3	Mus musculus	71-76
31311094-8	2019	Our data clearly demonstrate that melatonin has protective activity on lupus nephritis in these mice that is highly associated with its effect on enhancing the Nrf2 antioxidant signaling pathway and decreasing renal NLRP3 inflammasome activation.	Melatonin	34-43	NLR family, pyrin domain containing 3	Mus musculus	216-221
31354519-4	2019	However, whether TMAO mediates cardiac fibrosis via activating NLRP3 inflammasome remains unclear.	trimethyloxamine	17-21	NLR family, pyrin domain containing 3	Mus musculus	63-68
31354519-6	2019	TMAO exacerbated DOX-induced cardiac dysfunction, heart weight and cardiac fibrosis manifested by enhanced collagen accumulation, higher profibrotic levels and elevated inflammatory factors as well as NLRP3 inflammasome activation.	trimethyloxamine	0-4	NLR family, pyrin domain containing 3	Mus musculus	201-206
31354519-6	2019	TMAO exacerbated DOX-induced cardiac dysfunction, heart weight and cardiac fibrosis manifested by enhanced collagen accumulation, higher profibrotic levels and elevated inflammatory factors as well as NLRP3 inflammasome activation.	Doxorubicin	17-20	NLR family, pyrin domain containing 3	Mus musculus	201-206
31354519-8	2019	Furthermore, TMAO treatment induced NLRP3 inflammasome activation including oxidative stress in cultured cardiac fibroblast.	trimethyloxamine	13-17	NLR family, pyrin domain containing 3	Mus musculus	36-41
31354519-10	2019	Conclusion: Our data suggested that TMAO aggravated DOX-induced mouse cardiac fibrosis, at least in part, through activation of the NLRP3 inflammasome, providing a new potential target for preventing the progression of cardiac fibrosis.	trimethyloxamine	36-40	NLR family, pyrin domain containing 3	Mus musculus	132-137
31354519-10	2019	Conclusion: Our data suggested that TMAO aggravated DOX-induced mouse cardiac fibrosis, at least in part, through activation of the NLRP3 inflammasome, providing a new potential target for preventing the progression of cardiac fibrosis.	Doxorubicin	52-55	NLR family, pyrin domain containing 3	Mus musculus	132-137
31327964-0	2019	Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	80-85
31327964-7	2019	Melatonin increased mobility time of LPS-induced DLB mice and suppressed NLRP3 expression and interleukin-1beta (IL-1beta) cleavage in the hippocampus.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	73-78
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Melatonin	22-31	NLR family, pyrin domain containing 3	Mus musculus	86-91
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Melatonin	22-31	NLR family, pyrin domain containing 3	Mus musculus	173-178
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Adenosine	49-58	NLR family, pyrin domain containing 3	Mus musculus	86-91
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Adenosine Triphosphate	73-76	NLR family, pyrin domain containing 3	Mus musculus	86-91
31327964-9	2019	Our results show that melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition of NLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1beta (IL-1beta) maturation and secretion.	Adenosine Triphosphate	73-76	NLR family, pyrin domain containing 3	Mus musculus	173-178
31327964-11	2019	The beneficial effects of melatonin on NLRP3 inflammasome activation were associated with nuclear factor erythroid 2-related factor 2 (Nrf2) and Silent information regulator 2 homolog 1 (SIRT1) activation, which were reversed by Nrf2 siRNA and SIRT1 inhibitor treatment.	Melatonin	26-35	NLR family, pyrin domain containing 3	Mus musculus	39-44
31010959-6	2019	We found that LDL cholesterol lowering was dispensable, but statin-induced lowering of isoprenoids required for protein prenylation triggered NLRP3/caspase-1 inflammasome activation and interleukin-1beta (IL-1beta)-dependent insulin resistance in adipose tissue.	Terpenes	87-98	NLR family, pyrin domain containing 3	Mus musculus	142-147
30999127-0	2019	Carbenoxolone ameliorates insulin sensitivity in obese mice induced by high fat diet via regulating the IkappaB-alpha/NF-kappaB pathway and NLRP3 inflammasome.	Carbenoxolone	0-13	NLR family, pyrin domain containing 3	Mus musculus	140-145
30999127-7	2019	Besides, treatment with CBX could significantly reduce expressions of p-IkappaB-alpha, p-NF-kappaB, p-IRS-1, NLRP3 and inflammatory factors, increase expressions of p-PI3K and p-AKT.	Carbenoxolone	24-27	NLR family, pyrin domain containing 3	Mus musculus	109-114
31384532-0	2019	Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury.	Aspirin	0-7	NLR family, pyrin domain containing 3	Mus musculus	78-83
31384532-3	2019	We hypothesized that low-dose aspirin could ameliorate endothelial injury by inhibiting the activation of NLRP3 inflammasomes and ultimately prevent cardiovascular diseases.	Aspirin	30-37	NLR family, pyrin domain containing 3	Mus musculus	106-111
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	Aspirin	14-21	NLR family, pyrin domain containing 3	Mus musculus	36-41
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	Aspirin	14-21	NLR family, pyrin domain containing 3	Mus musculus	146-151
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	ros	173-176	NLR family, pyrin domain containing 3	Mus musculus	36-41
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	ros	173-176	NLR family, pyrin domain containing 3	Mus musculus	146-151
31384532-8	2019	We also found that low-concentration aspirin could inhibit the formation and activation of NLRP3 inflammasome and restore the expression of the endothelial tight junction protein zonula occludens-1/2 (ZO1/2).	Aspirin	37-44	NLR family, pyrin domain containing 3	Mus musculus	91-96
31384532-9	2019	We assume that aspirin can ameliorate the endothelial layer dysfunction by suppressing the activation of NLRP3 inflammasome.	Aspirin	15-22	NLR family, pyrin domain containing 3	Mus musculus	105-110
31384534-3	2019	Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli.	cardamonin	19-22	NLR family, pyrin domain containing 3	Mus musculus	57-62
31384534-4	2019	Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome.	cardamonin	29-32	NLR family, pyrin domain containing 3	Mus musculus	75-80
31384534-6	2019	We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.	cardamonin	25-28	NLR family, pyrin domain containing 3	Mus musculus	44-49
31384534-7	2019	Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1beta production induced by LPS in vivo, which is shown to be NLRP3 dependent.	cardamonin	13-16	NLR family, pyrin domain containing 3	Mus musculus	162-167
31384534-8	2019	In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.	cardamonin	36-39	NLR family, pyrin domain containing 3	Mus musculus	86-91
31384534-8	2019	In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases.	cardamonin	36-39	NLR family, pyrin domain containing 3	Mus musculus	151-156
30790702-6	2019	Socially defeated mice with KA treatment displayed enhanced vulnerability to subsequent dextran sulphate sodium (DSS)-induced colonic injury and inflammatory disturbance, and this effect was reversed by autophagic inhibition that blocked the NLRP3-suppressive effect of KA.	dss	113-116	NLR family, pyrin domain containing 3	Mus musculus	242-247
31082627-0	2019	Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.	Clomipramine	103-115	NLR family, pyrin domain containing 3	Mus musculus	30-35
30964965-6	2019	Interestingly, the protection offered by olaparib was further linked with the altered level of NLRP3 inflammasome-mediated IL-1beta release and consequent expression of its downstream targets matrix metalloproteinase-9 and transforming growth factor beta.	olaparib	41-49	NLR family, pyrin domain containing 3	Mus musculus	95-100
30738183-5	2019	Our results showed that the CS procedure induced the accumulation of inflammatory cells (macrophages, neutrophils, and lymphocytes), the production of cytokines, the activation of inflammasome components (NLRP3, ASC, caspase-1), depression-related behaviours, and the stimulation of GR signalling.	Cesium	28-30	NLR family, pyrin domain containing 3	Mus musculus	205-210
30790702-0	2019	Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress.	Kynurenic Acid	0-14	NLR family, pyrin domain containing 3	Mus musculus	36-41
30790702-3	2019	Here we show that kynurenic acid (KA) is an endogenous driver of social stress-exacerbated colitis via regulating the magnitude of NLRP3 inflammasome.	Kynurenic Acid	18-32	NLR family, pyrin domain containing 3	Mus musculus	131-136
30790702-6	2019	Socially defeated mice with KA treatment displayed enhanced vulnerability to subsequent dextran sulphate sodium (DSS)-induced colonic injury and inflammatory disturbance, and this effect was reversed by autophagic inhibition that blocked the NLRP3-suppressive effect of KA.	dextran sulphate sodium	88-111	NLR family, pyrin domain containing 3	Mus musculus	242-247
31082627-5	2019	Third, we utilized NLRP3 (NOD-like receptor protein 3) knock-out (KO) mice to prove that NLRP3 is involved in the effects of clomipramine.	Clomipramine	125-137	NLR family, pyrin domain containing 3	Mus musculus	89-94
31082627-9	2019	Clomipramine significantly reduced the LPS-induced increase in NLRP3 gene expression in BV2 cells.	Clomipramine	0-12	NLR family, pyrin domain containing 3	Mus musculus	63-68
31082627-10	2019	Furthermore, we utilized NLRP3 KO mice to explore whether NLPP3 was involved in this process and found that clomipramine treatment inhibits the LPS-induced increased expression of IL-1beta.	Clomipramine	108-120	NLR family, pyrin domain containing 3	Mus musculus	25-30
31082627-11	2019	CONCLUSION: These results imply that clomipramine could attenuate depressive behaviors and neuroinflammation induced by LPS via partial regulation of NLRP3.	Clomipramine	37-49	NLR family, pyrin domain containing 3	Mus musculus	150-155
30952009-7	2019	RESULTS: CS activated the NLRP3 inflammasome by activating NIMA-related kinase 7 (NEK7).	Cesium	9-11	NLR family, pyrin domain containing 3	Mus musculus	26-31
31217433-0	2019	Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1beta secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment.	Docosahexaenoic Acids	0-20	NLR family, pyrin domain containing 3	Mus musculus	35-40
30847567-0	2019	Tetramethylpyrazine ameliorates depression by inhibiting TLR4-NLRP3 inflammasome signal pathway in mice.	tetramethylpyrazine	0-19	NLR family, pyrin domain containing 3	Mus musculus	62-67
30847567-5	2019	In this study, we hypothesized that TMP ameliorates depression may be through the inhibition of the TLR4-NF-kappaB-NLRP3 signal pathway.	tetramethylpyrazine	36-39	NLR family, pyrin domain containing 3	Mus musculus	115-120
30847567-7	2019	Additionally, we also found that CUMS induced the upregulation of proinflammatory cytokines; TLR4 and NLRP3-associated proteins were significantly suppressed by TMP in the prefrontal cortex and hippocampus.	tetramethylpyrazine	161-164	NLR family, pyrin domain containing 3	Mus musculus	102-107
30847567-10	2019	Taken together, our findings suggested that TMP exerted a potential antidepressant-like effect in CUMS mice, and the molecular mechanisms may relate to inhibit the TLR4-NF-kappaB-NLRP3 signaling pathway in the brain.	tetramethylpyrazine	44-47	NLR family, pyrin domain containing 3	Mus musculus	179-184
31229895-0	2019	Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation.	Reactive Oxygen Species	67-90	NLR family, pyrin domain containing 3	Mus musculus	91-96
31229895-5	2019	Instead, Parkin deficiency augments innate antiviral inflammation by enhancing mitochondrial ROS (mtROS)-mediated NLRP3 inflammasome activation and promoting viral clearance.	Reactive Oxygen Species	93-96	NLR family, pyrin domain containing 3	Mus musculus	114-119
31233552-0	2019	Non-canonical NLRP3 inflammasome activation and IL-1beta signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4.	Leukotrienes	137-148	NLR family, pyrin domain containing 3	Mus musculus	14-19
31233552-7	2019	We showed that macrophages from NLRP3-/-, ASC-/-, Casp-1/11-/-, gp91phox-/- , and IL-1R-/- mice treated with ATP or LTB4 did not decrease parasitic load as was observed in WT mice.	Adenosine Triphosphate	109-112	NLR family, pyrin domain containing 3	Mus musculus	32-37
31234344-4	2019	We found that DHA enclosed in RV-SLNs significantly enhanced its ability to contrast the cytotoxic effect of SDS and to inhibit the SDS- and TNF-alpha-induced production of the inflammatory cytokines IL-1beta, IL-6, and 1 MCP-1, in the two keratinocyte cell lines, as well as the NLRP3 inflammasome activation.	Docosahexaenoic Acids	14-17	NLR family, pyrin domain containing 3	Mus musculus	280-285
31217433-9	2019	The repression of 5-FU-induced caspase-1 activity by DHA supplementation is partially due to beta-arrestin-2-dependent inhibition of NLRP3 inflammasome activity but was independent of JNK pathway.	Fluorouracil	18-22	NLR family, pyrin domain containing 3	Mus musculus	133-138
31217433-9	2019	The repression of 5-FU-induced caspase-1 activity by DHA supplementation is partially due to beta-arrestin-2-dependent inhibition of NLRP3 inflammasome activity but was independent of JNK pathway.	Docosahexaenoic Acids	53-56	NLR family, pyrin domain containing 3	Mus musculus	133-138
31217433-2	2019	Release of mature IL-1beta is a consequence of 5-FU-mediated NLRP3 activation and subsequent caspase-1 activity in MDSC.	Fluorouracil	47-51	NLR family, pyrin domain containing 3	Mus musculus	61-66
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	NLR family, pyrin domain containing 3	Mus musculus	141-146
31002919-6	2019	MCC950 was utilized as a selective NLRP3 inflammasome inhibitor.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	35-40
31002919-9	2019	Inhibition the NLRP3 inflammasome signalling by treatment with MCC950 decreased the activation of IL-23/IL-17 axis and the expression of IL-23R.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	63-69	NLR family, pyrin domain containing 3	Mus musculus	15-20
31338007-0	2019	Deoxynivalenol enhances IL-1ss expression in BV2 microglial cells through activation of the NF-?B pathway and the ASC/NLRP3 inflammasome.	deoxynivalenol	0-14	NLR family, pyrin domain containing 3	Mus musculus	118-123
31186013-0	2019	Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-kappaB pathways.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	114-119
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	NLR family, pyrin domain containing 3	Mus musculus	54-59
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	NLR family, pyrin domain containing 3	Mus musculus	141-146
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	NLR family, pyrin domain containing 3	Mus musculus	141-146
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	NLR family, pyrin domain containing 3	Mus musculus	141-146
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	88-91	NLR family, pyrin domain containing 3	Mus musculus	141-146
31338007-7	2019	Thus, components of the inflammasome, such as ASC and NLRP3, significantly increased by DON treatment; in addition, the knockdown of ASC and NLRP3 markedly downregulated DON-induced IL-1beta secretion, but not IL-1beta gene expression, which indicated that DON promoted IL-1beta secretion through the ASC/NLRP3 inflammasome.	deoxynivalenol	170-173	NLR family, pyrin domain containing 3	Mus musculus	141-146
31338007-8	2019	Collectively, the data suggested that DON induced IL-1beta expression in BV2 microglial cells through the activation of the NF-kappaB signaling pathway and the subsequent upregulation of the ASC/NLRP3 inflammasome.	deoxynivalenol	38-41	NLR family, pyrin domain containing 3	Mus musculus	195-200
31170267-5	2019	The important role of NLRP3 activation in STSLS is further confirmed in vivo with the NLRP3 inhibitor MCC950 and nlrp3-knockout mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	102-108	NLR family, pyrin domain containing 3	Mus musculus	22-27
31181689-8	2019	Besides, EPD decreased the imiquimod-induced expression levels of TLR7, TLR8, TRAF6, MyD88, p-IKKalpha, p-IKBalpha, p-NF-kappaB, NLRP3, apoptosis-associated speck-like protein contained a caspase recruitment domain (ASC), cysteinyl aspartate specific proteinase 1 (caspase-1), and IL-1beta.	Imiquimod	27-36	NLR family, pyrin domain containing 3	Mus musculus	129-134
31281589-7	2019	All pretreatments inhibited the activation of the TLR4/NF-kappaB pathway, while A967079 alone, and combined with AMG9810 also reduced the activation of the NLRP3/caspase-1 pathway.	A 967079	80-87	NLR family, pyrin domain containing 3	Mus musculus	156-161
31281589-7	2019	All pretreatments inhibited the activation of the TLR4/NF-kappaB pathway, while A967079 alone, and combined with AMG9810 also reduced the activation of the NLRP3/caspase-1 pathway.	3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide	113-120	NLR family, pyrin domain containing 3	Mus musculus	156-161
31182681-0	2019	Kainic acid Induces production and aggregation of amyloid beta-protein and memory deficits by activating inflammasomes in NLRP3- and NF-kappaB-stimulated pathways.	Kainic Acid	0-11	NLR family, pyrin domain containing 3	Mus musculus	122-127
31182681-7	2019	Inhibition of NLRP3 or NF-kappaB by Bay11-7082 caused a reduction in the KA-induced expression of interleukin (IL)-1beta and BDNF.	3-(4-methylphenylsulfonyl)-2-propenenitrile	36-46	NLR family, pyrin domain containing 3	Mus musculus	14-19
31174271-0	2019	Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis.	epigallocatechin gallate	0-26	NLR family, pyrin domain containing 3	Mus musculus	62-67
31174271-3	2019	We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation.	epigallocatechin gallate	24-50	NLR family, pyrin domain containing 3	Mus musculus	91-96
31174271-3	2019	We investigated whether epigallocatechin-3-gallate (EGCG) suppresses the activation of the NLRP3 inflammasome, thereby effectively preventing gouty inflammation.	epigallocatechin gallate	52-56	NLR family, pyrin domain containing 3	Mus musculus	91-96
31174271-4	2019	EGCG blocked MSU crystal-induced production of caspase-1(p10) and interleukin-1beta in primary mouse macrophages, indicating its suppressive effect on the NLRP3 inflammasome.	epigallocatechin gallate	0-4	NLR family, pyrin domain containing 3	Mus musculus	155-160
31174271-6	2019	The in vivo suppressive effects of EGCG correlated well with the suppression of the NLRP3 inflammasome in mouse foot tissue.	epigallocatechin gallate	35-39	NLR family, pyrin domain containing 3	Mus musculus	84-89
31174271-7	2019	EGCG inhibited the de novo synthesis of mitochondrial DNA as well as the production of reactive oxygen species in primary mouse macrophages, contributing to the suppression of the NLRP3 inflammasome.	epigallocatechin gallate	0-4	NLR family, pyrin domain containing 3	Mus musculus	180-185
31174271-7	2019	EGCG inhibited the de novo synthesis of mitochondrial DNA as well as the production of reactive oxygen species in primary mouse macrophages, contributing to the suppression of the NLRP3 inflammasome.	Reactive Oxygen Species	87-110	NLR family, pyrin domain containing 3	Mus musculus	180-185
31174271-8	2019	These results show that EGCG suppresses the activation of the NLRP3 inflammasome in macrophages via the blockade of mitochondrial DNA synthesis, contributing to the prevention of gouty inflammation.	epigallocatechin gallate	24-28	NLR family, pyrin domain containing 3	Mus musculus	62-67
31174271-9	2019	The inhibitory effects of EGCG on the NLRP3 inflammasome make EGCG a promising therapeutic option for NLRP3-dependent diseases such as gout.	epigallocatechin gallate	26-30	NLR family, pyrin domain containing 3	Mus musculus	38-43
31174271-9	2019	The inhibitory effects of EGCG on the NLRP3 inflammasome make EGCG a promising therapeutic option for NLRP3-dependent diseases such as gout.	epigallocatechin gallate	26-30	NLR family, pyrin domain containing 3	Mus musculus	102-107
31174271-9	2019	The inhibitory effects of EGCG on the NLRP3 inflammasome make EGCG a promising therapeutic option for NLRP3-dependent diseases such as gout.	epigallocatechin gallate	62-66	NLR family, pyrin domain containing 3	Mus musculus	38-43
31174271-9	2019	The inhibitory effects of EGCG on the NLRP3 inflammasome make EGCG a promising therapeutic option for NLRP3-dependent diseases such as gout.	epigallocatechin gallate	62-66	NLR family, pyrin domain containing 3	Mus musculus	102-107
31407595-5	2019	In the DMM group, the expression of the OA biomarkers MMP-13, NLRP3 significantly increased, whilst Collagen II and LC-3B levels were significantly lower than other experimental groups.	dimethylmyleran	7-10	NLR family, pyrin domain containing 3	Mus musculus	62-67
31170267-5	2019	The important role of NLRP3 activation in STSLS is further confirmed in vivo with the NLRP3 inhibitor MCC950 and nlrp3-knockout mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	102-108	NLR family, pyrin domain containing 3	Mus musculus	86-91
31134844-0	2019	Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing cytokine production in mice.	pulegone	0-8	NLR family, pyrin domain containing 3	Mus musculus	50-55
31026586-3	2019	Therefore, the aim of our research was to determine whether H2S exerts an anti-inflammatory effect on DSS-induced colitis by targeting NLRP3 inflammasome.	Hydrogen Sulfide	60-63	NLR family, pyrin domain containing 3	Mus musculus	135-140
31026586-3	2019	Therefore, the aim of our research was to determine whether H2S exerts an anti-inflammatory effect on DSS-induced colitis by targeting NLRP3 inflammasome.	Dextran Sulfate	102-105	NLR family, pyrin domain containing 3	Mus musculus	135-140
31026586-6	2019	Besides, H2S markedly suppressed the expression of NLRP3 and cleaved caspase-1 (p20) in colons from DSS-induced colitis mice.	Hydrogen Sulfide	9-12	NLR family, pyrin domain containing 3	Mus musculus	51-56
31026586-6	2019	Besides, H2S markedly suppressed the expression of NLRP3 and cleaved caspase-1 (p20) in colons from DSS-induced colitis mice.	Dextran Sulfate	100-103	NLR family, pyrin domain containing 3	Mus musculus	51-56
31026586-8	2019	Our experimental results also suggested that H2S dose-dependently inhibits the activation of NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs) by reducing the cleavage of caspase-1 and the secretion of IL-1beta.	Hydrogen Sulfide	45-48	NLR family, pyrin domain containing 3	Mus musculus	93-98
31026586-10	2019	Collectively, our study confirms that H2S exerts its protective effect on DSS-induced mouse colitis at least partly by inhibiting the activation of NLRP3 inflammasome pathway.	Hydrogen Sulfide	38-41	NLR family, pyrin domain containing 3	Mus musculus	148-153
31026586-10	2019	Collectively, our study confirms that H2S exerts its protective effect on DSS-induced mouse colitis at least partly by inhibiting the activation of NLRP3 inflammasome pathway.	Dextran Sulfate	74-77	NLR family, pyrin domain containing 3	Mus musculus	148-153
30326194-0	2019	Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation 1.	Docosahexaenoic Acids	61-81	NLR family, pyrin domain containing 3	Mus musculus	99-104
30326194-4	2019	In contrast with EPA and 17,18-EEQ, DHA and 19,20-EDP exerted cardioprotection, as shown by a significant improvement in postischemic functional recovery associated with significant attenuation of NLRP3 inflammasome complex activation and preserved mitochondrial function.	Docosahexaenoic Acids	36-39	NLR family, pyrin domain containing 3	Mus musculus	197-202
30326194-4	2019	In contrast with EPA and 17,18-EEQ, DHA and 19,20-EDP exerted cardioprotection, as shown by a significant improvement in postischemic functional recovery associated with significant attenuation of NLRP3 inflammasome complex activation and preserved mitochondrial function.	19(20)-EpDPE	44-53	NLR family, pyrin domain containing 3	Mus musculus	197-202
30326194-9	2019	Interestingly, 19,20-EDP provided the best protection against IR injury via maintaining mitochondrial function and thereby reducing the detrimental NLRP3 inflammasome responses.	19(20)-EpDPE	15-24	NLR family, pyrin domain containing 3	Mus musculus	148-153
31026586-0	2019	Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.	Hydrogen Sulfide	0-16	NLR family, pyrin domain containing 3	Mus musculus	68-73
31026586-0	2019	Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome.	Dextran Sulfate	34-37	NLR family, pyrin domain containing 3	Mus musculus	68-73
31026586-2	2019	In addition, the NLRP3 inflammasome is a key player in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	75-97	NLR family, pyrin domain containing 3	Mus musculus	17-22
31026586-2	2019	In addition, the NLRP3 inflammasome is a key player in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	99-102	NLR family, pyrin domain containing 3	Mus musculus	17-22
31134844-3	2019	Objective: Here, the modulatory effects of pulegone on NLRP3 inflammasome were investigated.	pulegone	43-51	NLR family, pyrin domain containing 3	Mus musculus	55-60
31134844-7	2019	In addition, a reduced mRNA and protein expression production of ASC, NLRP3, and Caspase-1 were detected in lungs after pulegone administration.	pulegone	120-128	NLR family, pyrin domain containing 3	Mus musculus	70-75
31134844-10	2019	Conclusion: Pulegone exerts anti-inflammatory effects on LPS-induced sepsis mice via inhibition of the NLRP3 expression.	pulegone	12-20	NLR family, pyrin domain containing 3	Mus musculus	103-108
30901677-4	2019	The effects of Genistein in dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome was investigated in this study.	Genistein	15-24	NLR family, pyrin domain containing 3	Mus musculus	94-99
30901677-4	2019	The effects of Genistein in dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome was investigated in this study.	Dextran Sulfate	28-50	NLR family, pyrin domain containing 3	Mus musculus	94-99
30927050-0	2019	alpha-Mangostin suppresses NLRP3 inflammasome activation via promoting autophagy in LPS-stimulated murine macrophages and protects against CLP-induced sepsis in mice.	mangostin	0-15	NLR family, pyrin domain containing 3	Mus musculus	27-32
30901677-4	2019	The effects of Genistein in dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome was investigated in this study.	Dextran Sulfate	52-55	NLR family, pyrin domain containing 3	Mus musculus	94-99
31556748-7	2019	Results: In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP.	Hydroxychloroquine	44-47	NLR family, pyrin domain containing 3	Mus musculus	77-82
30952097-0	2019	Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway.	Ketones	21-27	NLR family, pyrin domain containing 3	Mus musculus	100-105
30952097-0	2019	Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway.	lps	36-39	NLR family, pyrin domain containing 3	Mus musculus	100-105
30952097-0	2019	Protective effect of Ketone musk on LPS/ATP-induced pyroptosis in J774A.1 cells through suppressing NLRP3/GSDMD pathway.	Adenosine Triphosphate	40-43	NLR family, pyrin domain containing 3	Mus musculus	100-105
30952097-5	2019	Our present study demonstrated that KM inhibited LPS/ATP-induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome.	lps	49-52	NLR family, pyrin domain containing 3	Mus musculus	196-201
30952097-5	2019	Our present study demonstrated that KM inhibited LPS/ATP-induced pyroptosis and the release of IL-1beta/18 in J774A.1 cells by inhibiting the activation of GSDMD and caspase-1 and the assembly of NLRP3 inflammasome.	Adenosine Triphosphate	53-56	NLR family, pyrin domain containing 3	Mus musculus	196-201
31556748-9	2019	Ex vivo culture of alveolar macrophages collected from cSiO2-treated mice showed significantly less NLRP3 inflammasome activation after in vivo exposure to HCQ.	csio2	55-60	NLR family, pyrin domain containing 3	Mus musculus	100-105
31556748-9	2019	Ex vivo culture of alveolar macrophages collected from cSiO2-treated mice showed significantly less NLRP3 inflammasome activation after in vivo exposure to HCQ.	Hydroxychloroquine	156-159	NLR family, pyrin domain containing 3	Mus musculus	100-105
30700851-10	2019	Along with impaired mitophagy, mRNA and protein levels of NLRP3, caspase-1, IL-18 and IL-1beta were upregulated by PA treatment.	Palmitic Acid	115-117	NLR family, pyrin domain containing 3	Mus musculus	58-63
31156650-0	2019	Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation.	Paclitaxel	23-33	NLR family, pyrin domain containing 3	Mus musculus	54-59
29885344-3	2019	CCH strongly enhanced NLRP3, activated caspase-1 and IL-1beta expressions in hippocampus and thalamus at age 12 M of AD mice.	1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine	0-3	NLR family, pyrin domain containing 3	Mus musculus	22-27
31009850-0	2019	Bavachin attenuates LPS-induced inflammatory response and inhibits the activation of NLRP3 inflammasome in macrophages.	bavachin	0-8	NLR family, pyrin domain containing 3	Mus musculus	85-90
31121492-9	2019	Additionally, LPS stimulation also promoted the production of intracellular reactive oxygen (ROS), which further induced the NLRP3 translocation to the cytoplasm from the nucleus.	reactive oxygen	76-91	NLR family, pyrin domain containing 3	Mus musculus	125-130
31121492-9	2019	Additionally, LPS stimulation also promoted the production of intracellular reactive oxygen (ROS), which further induced the NLRP3 translocation to the cytoplasm from the nucleus.	ros	93-96	NLR family, pyrin domain containing 3	Mus musculus	125-130
31239738-8	2019	Moreover, fasting-induced hepatic steatosis and accompanied liver injury were ameliorated when mice were intraperitoneally injected with MCC950 (a selective NLRP3 inhibitor).	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	137-143	NLR family, pyrin domain containing 3	Mus musculus	157-162
31239738-10	2019	Conclusion: The NLRP3 inhibitor-MCC950 protects against fasting-induced hepatic steatosis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	32-38	NLR family, pyrin domain containing 3	Mus musculus	16-21
31009850-13	2019	Additionally, bavachin suppressed NLRP3 inflammasome-derived IL-1beta secretion, decreased caspase-1 activation, repressed mature IL-1beta expression, and inhibited inflammasome complex formation.	bavachin	14-22	NLR family, pyrin domain containing 3	Mus musculus	34-39
31009850-15	2019	CONCLUSION: Our experimental results indicated anti-inflammatory effects of bavachin exhibit attenuation of LPS-induced inflammation and inhibit activation of NLRP3 inflammasome in macrophages.	bavachin	76-84	NLR family, pyrin domain containing 3	Mus musculus	159-164
31089880-2	2019	Therefore, we became interested in the role of the Nlrp3 inflammasome in this process and show for the first time that its activation in ATP-dependent manner orchestrates BM egress of hematopoietic stem/progenitor cells (HSPCs) as well as other stem cells, including mesenchymal stroma cells (MSCs), endothelial progenitor cells (EPCs), and very small embryonic-like stem cells (VSELs).	Adenosine Triphosphate	137-140	NLR family, pyrin domain containing 3	Mus musculus	51-56
31089880-4	2019	In support of this mechanism, we demonstrate that the Nlrp3 inflammasome become activated in innate immunity cells by granulocyte colony stimulating factor (G-CSF) and AMD3100 in an ATP-dependent manner.	Adenosine Triphosphate	182-185	NLR family, pyrin domain containing 3	Mus musculus	54-59
31089880-5	2019	Moreover, administration of the Nlrp3 inflammasome activator nigericin induces mobilization in mice, and the opposite effect is obtained by administration of an Nlrp3 inhibitor (MCC950) to mice mobilized by G-CSF or AMD3100.	Nigericin	61-70	NLR family, pyrin domain containing 3	Mus musculus	32-37
31089880-6	2019	In summary, our results further support the crucial role of innate immunity, BM sterile inflammation, and novel role of the ATP-Nlrp3-ComC axis in the egress of stem cells into PB.	Adenosine Triphosphate	124-127	NLR family, pyrin domain containing 3	Mus musculus	128-133
31016965-10	2019	Additionally, the enhanced IL-1beta secretion in the presence of 50 muM MEHP ( P < 0.01) also supports inflammasome activation (significant ASC and NLRP3 protein augmentation).	mono-(2-ethylhexyl)phthalate	72-76	NLR family, pyrin domain containing 3	Mus musculus	148-153
31097691-7	2019	The protein levels of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome components NLRP3, apoptosis-related spotted protein (ASC) and cysteinyl aspartate-specific protease-1 (caspase-1) were increased in GSK1016790A-injected mice, which indicated NLRP3 inflammasome activation.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	257-268	NLR family, pyrin domain containing 3	Mus musculus	105-110
31156650-6	2019	However, paclitaxel could induce robust activation of caspase-1 in BMDMs in the presence of NLRP3 inflammasome-activating signal 2, such as ATP or nigericin.	Paclitaxel	9-19	NLR family, pyrin domain containing 3	Mus musculus	92-97
30703369-8	2019	Furthermore, administration of OL-CM reduced the expression of pro-inflammatory cytokines and suppressed the activation of NLRP3-inflammasome complex in EAE mice.	ol-cm	31-36	NLR family, pyrin domain containing 3	Mus musculus	123-128
31156650-6	2019	However, paclitaxel could induce robust activation of caspase-1 in BMDMs in the presence of NLRP3 inflammasome-activating signal 2, such as ATP or nigericin.	Adenosine Triphosphate	140-143	NLR family, pyrin domain containing 3	Mus musculus	92-97
31156650-7	2019	This paclitaxel/ATP-mediated inflammasome activation was completely abrogated in Nlrp3-deficient macrophages.	Paclitaxel	5-15	NLR family, pyrin domain containing 3	Mus musculus	81-86
31156650-7	2019	This paclitaxel/ATP-mediated inflammasome activation was completely abrogated in Nlrp3-deficient macrophages.	Adenosine Triphosphate	16-19	NLR family, pyrin domain containing 3	Mus musculus	81-86
31156650-10	2019	These findings suggest that paclitaxel can drive the priming of signal-mediated events for NLRP3 activation but not a second signal-triggered phenomenon such as mitochondrial damage.	Paclitaxel	28-38	NLR family, pyrin domain containing 3	Mus musculus	91-96
31156650-12	2019	Collectively, our data strongly indicate that paclitaxel is able to facilitate the activation of NLRP3 inflammasome signaling in a certain physiological environment.	Paclitaxel	46-56	NLR family, pyrin domain containing 3	Mus musculus	97-102
30902848-4	2019	Emerging evidence suggests that therapeutics designed for cancer chemotherapy or inflammatory disorders such as SMAC mimetics, TAK1 inhibitors and BH3 mimetics promote caspase-8 or caspase-9-dependent inflammatory cell death and NLRP3 inflammasome activation.	BH 3	147-150	NLR family, pyrin domain containing 3	Mus musculus	229-234
30896354-0	2019	Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome.	Silymarin	0-9	NLR family, pyrin domain containing 3	Mus musculus	160-165
31308035-0	2019	Anti-inflammatory Effects of Dopamine in Lipopolysaccharide (LPS)-stimulated RAW264.7 Cells via Inhibiting NLRP3 Inflammasome Activation.	Dopamine	29-37	NLR family, pyrin domain containing 3	Mus musculus	107-112
30560913-0	2019	Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via JNK and NF-kappaB pathways in acute glaucoma.	kaempferol	0-10	NLR family, pyrin domain containing 3	Mus musculus	71-76
30560913-9	2019	The activations of caspase-8, caspase-3, and NLRP1/NLRP3 inflammasome activation were inhibited by kaempferol.	kaempferol	99-109	NLR family, pyrin domain containing 3	Mus musculus	51-56
30560913-12	2019	CONCLUSION: Kaempferol attenuated retinal ganglion cell death by suppressing NLRP1/NLRP3 inflammasomes and caspase-8 via inhibiting NF-kappaB and JNK pathways in acute glaucoma.	kaempferol	12-22	NLR family, pyrin domain containing 3	Mus musculus	83-88
31118933-0	2019	Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation.	naringenin	0-10	NLR family, pyrin domain containing 3	Mus musculus	112-117
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	13-16	NLR family, pyrin domain containing 3	Mus musculus	91-96
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	13-16	NLR family, pyrin domain containing 3	Mus musculus	322-327
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	Dopamine	26-28	NLR family, pyrin domain containing 3	Mus musculus	91-96
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	Dopamine	26-28	NLR family, pyrin domain containing 3	Mus musculus	322-327
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	160-163	NLR family, pyrin domain containing 3	Mus musculus	91-96
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	160-163	NLR family, pyrin domain containing 3	Mus musculus	322-327
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	160-163	NLR family, pyrin domain containing 3	Mus musculus	91-96
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	naringenin	160-163	NLR family, pyrin domain containing 3	Mus musculus	322-327
31118933-11	2019	In addition, NAR-mediated DA neuroprotection was dependent on the inhibition of microglial NLRP3 inflammasome activation, as evidenced by the observations that NAR-reduced pro-inflammatory factors production and further NAR-exerted DA neuroprotection against LPS-induced neuronal damage was not discerned after microglial NLRP3 siRNA treatment.	Dopamine	232-234	NLR family, pyrin domain containing 3	Mus musculus	91-96
31118933-12	2019	Conclusions: This study demonstrated that NAR targeted microglial NLRP3 inflammasome to protect DA neurons against LPS-induced neurotoxicity.	Dopamine	96-98	NLR family, pyrin domain containing 3	Mus musculus	66-71
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	nitro	4-9	NLR family, pyrin domain containing 3	Mus musculus	57-62
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	quinazolin-4(3 h)-one	22-43	NLR family, pyrin domain containing 3	Mus musculus	57-62
30896160-5	2019	The nitro-substituted quinazolin-4(3 H)-one 2k inhibited NLRP3 inflammasome (IC50 5 muM) via the suppression of IL-1beta release from ATP-stimulated J774A.1 cells.	Adenosine Triphosphate	134-137	NLR family, pyrin domain containing 3	Mus musculus	57-62
31308035-7	2019	DA also inhibited the mRNA and protein expression levels of nitric oxide synthase (iNOS) and downregulated NLRP3 and caspase-1 expression.	Dopamine	0-2	NLR family, pyrin domain containing 3	Mus musculus	107-112
31308035-8	2019	The administration of DA and NLRP3 inhibitor, MCC950 played a synergistic role in suppressing NLRP3 activity.	Dopamine	22-24	NLR family, pyrin domain containing 3	Mus musculus	94-99
31308035-9	2019	CONCLUSION: Taken together, these findings demonstrate that DA displays potent anti-inflammatory effects that are mediated by the suppression of pro-inflammatory mediators (IL-1beta, IL-6, TNF-alpha), cytokines (iNOS) and the NLRP3 inflammasome activation.	Dopamine	60-62	NLR family, pyrin domain containing 3	Mus musculus	226-231
31308035-10	2019	Improvement of DA correlated with its effect on NLRP3 activation.	Dopamine	15-17	NLR family, pyrin domain containing 3	Mus musculus	48-53
30615886-7	2019	TBI induced NLRP3 inflammasome activation and mitochondrial dysfunction, including increased caspase-1 p20 expression, exacerbated the secretion of LDH, IL-1beta and IL-18, and disorder of ATP, MMP, ROS and mitophagy (Pink1 and LC3 expression in mitochondria).	Adenosine Triphosphate	189-192	NLR family, pyrin domain containing 3	Mus musculus	12-17
30615886-7	2019	TBI induced NLRP3 inflammasome activation and mitochondrial dysfunction, including increased caspase-1 p20 expression, exacerbated the secretion of LDH, IL-1beta and IL-18, and disorder of ATP, MMP, ROS and mitophagy (Pink1 and LC3 expression in mitochondria).	ros	199-202	NLR family, pyrin domain containing 3	Mus musculus	12-17
30698909-11	2019	Furthermore, the ability of tumor formation in nude mice, the rates of clone formation and positive cells, mRNA and protein levels of NLRP3 inflammasome activation-related factors in LPS + CTPE-induced cells were all higher than those in cells stimulated with CTPE alone.	ctpe	189-193	NLR family, pyrin domain containing 3	Mus musculus	134-139
30802677-0	2019	The selective NLRP3 inflammasome inhibitor MCC950 alleviates cholestatic liver injury and fibrosis in mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	43-49	NLR family, pyrin domain containing 3	Mus musculus	14-19
30802677-2	2019	MCC950, a small-molecule NLRP3 inhibitor, was previously shown to have anti-inflammatory effects.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	25-30
30896354-0	2019	Silymarin and silymarin nanoparticles guard against chronic unpredictable mild stress induced depressive-like behavior in mice: involvement of neurogenesis and NLRP3 inflammasome.	Silymarin	14-23	NLR family, pyrin domain containing 3	Mus musculus	160-165
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	gadolinium chloride	195-200	NLR family, pyrin domain containing 3	Mus musculus	74-79
30585631-2	2019	Purple sweet potato color (PSPC), one type of flavonoid, has been demonstrated to suppress endothelial senescence and restore endothelial function in diabetic mice by inhibiting the nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome.	Flavonoids	46-55	NLR family, pyrin domain containing 3	Mus musculus	284-289
30589073-4	2019	In brief, our results showed that, NLRP3 inflammasome inhibitor BAY 11-7082 or A438079 inhibited activation of NLRP3 inflammasome, alleviated mitochondrial dysfunction, the number of macrophage and neutrophil, thereby attenuating alveolar type II cell apoptosis, lung edema, and histological injury.	3-(4-methylphenylsulfonyl)-2-propenenitrile	64-75	NLR family, pyrin domain containing 3	Mus musculus	35-40
30589073-4	2019	In brief, our results showed that, NLRP3 inflammasome inhibitor BAY 11-7082 or A438079 inhibited activation of NLRP3 inflammasome, alleviated mitochondrial dysfunction, the number of macrophage and neutrophil, thereby attenuating alveolar type II cell apoptosis, lung edema, and histological injury.	3-(4-methylphenylsulfonyl)-2-propenenitrile	64-75	NLR family, pyrin domain containing 3	Mus musculus	111-116
30589073-4	2019	In brief, our results showed that, NLRP3 inflammasome inhibitor BAY 11-7082 or A438079 inhibited activation of NLRP3 inflammasome, alleviated mitochondrial dysfunction, the number of macrophage and neutrophil, thereby attenuating alveolar type II cell apoptosis, lung edema, and histological injury.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	79-86	NLR family, pyrin domain containing 3	Mus musculus	111-116
30589073-5	2019	Taken together, our data reveal that NLRP3 inflammasome inhibitor BAY 11-7082 or A438079 attenuates the inflammatory response, reverses mitochondrial dysfunction, and subsequently alleviates secondary lung injury following SCI.	3-(4-methylphenylsulfonyl)-2-propenenitrile	66-77	NLR family, pyrin domain containing 3	Mus musculus	37-42
30589073-5	2019	Taken together, our data reveal that NLRP3 inflammasome inhibitor BAY 11-7082 or A438079 attenuates the inflammatory response, reverses mitochondrial dysfunction, and subsequently alleviates secondary lung injury following SCI.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	81-88	NLR family, pyrin domain containing 3	Mus musculus	37-42
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	Hydrogen Peroxide	29-33	NLR family, pyrin domain containing 3	Mus musculus	74-79
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	Hydrogen Peroxide	29-33	NLR family, pyrin domain containing 3	Mus musculus	254-259
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	Hydrogen Peroxide	29-33	NLR family, pyrin domain containing 3	Mus musculus	254-259
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	gadolinium chloride	195-200	NLR family, pyrin domain containing 3	Mus musculus	254-259
31060676-3	2019	Results After treatment with H2O2,the expression of caspase-1 protein and NLRP3 mRNA in BV2 cells was increased,and IL-1beta protein in BV2 cells was significantly increased after treatment with GdCl3(P=0.0036).After treatment with CA-074Me,the doses of NLRP3 mRNA(P=0.037),caspase-1(P=0.021),and IL-1beta(P= 0.036)were significantly reduced.Cells in the H2O2 group and H2O2+GdCl3 group grew more slowly.The expressions of CTSB mRNA and TRPML1 mRNA,or CTSB and TRPML1 proteins in BV2 cells in the treatment group with 200 mumol/L of H2O2 concentration were similar.H2O2-induced CTSB protein expression was inhibited after silencing TRPML1 gene.The changes of other cathepsins were not affected for the different concentration of H2O2.In the BV2 cells treated with TRPML1 gene silencing,the expression of CTSB protein was significantly reduced and the difference was statistically significant(P=0.021)between the H2O2 +siRNA treatment group and the H2O2 treatment group.&lt;b&gt;Conclusion&lt;/b&gt; CTSB regulates the activation of NLRP3 inflammasome in the oxidative stress model of microglia cells,probably mediated by calcium channel protein TRPML1.	gadolinium chloride	195-200	NLR family, pyrin domain containing 3	Mus musculus	254-259
31023362-10	2019	The possible mechanisms of the underlying effects of baicalein on ROS production and signaling pathways of Nrf2/heme-oxygenase (HO)-1, NLRP3 inflammasome, and NF-kappaB phosphorylation in lipopolysaccharide (LPS)-primed MDSCs were analyzed.	baicalein	53-62	NLR family, pyrin domain containing 3	Mus musculus	135-140
31106156-6	2019	Besides, e-As4S4 could also inhibit the activation of hypoxia-inducible factor-1alpha (HIF-1alpha) and NLRP3 inflammasomes.	e-as4s4	9-16	NLR family, pyrin domain containing 3	Mus musculus	103-108
31023362-10	2019	The possible mechanisms of the underlying effects of baicalein on ROS production and signaling pathways of Nrf2/heme-oxygenase (HO)-1, NLRP3 inflammasome, and NF-kappaB phosphorylation in lipopolysaccharide (LPS)-primed MDSCs were analyzed.	Reactive Oxygen Species	66-69	NLR family, pyrin domain containing 3	Mus musculus	135-140
31023362-15	2019	CONCLUSION: The data show that baicalein alleviates the symptoms of pristane-induced LN and suggest that the alleviation may be attributed to inhibition of MDSC expansion and regulation of the balance of the Nrf2/HO-1 signal and NLRP3 expression in MDSCs.	baicalein	31-40	NLR family, pyrin domain containing 3	Mus musculus	229-234
31023362-15	2019	CONCLUSION: The data show that baicalein alleviates the symptoms of pristane-induced LN and suggest that the alleviation may be attributed to inhibition of MDSC expansion and regulation of the balance of the Nrf2/HO-1 signal and NLRP3 expression in MDSCs.	pristane	68-76	NLR family, pyrin domain containing 3	Mus musculus	229-234
31019207-4	2019	Our data show that in microglia Abeta causes P2X7R-dependent a) NFkappaB activation; b) NLRP3 inflammasome expression and function; c) mitochondria toxicity; and these changes are fully inhibited by nimodipine.	Nimodipine	199-209	NLR family, pyrin domain containing 3	Mus musculus	88-93
30716318-0	2019	Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-kappaB/NLRP3 inflammasome signalling pathway in mice.	Harmine	0-7	NLR family, pyrin domain containing 3	Mus musculus	91-96
31019207-3	2019	In the present study, we used the N13 microglia cell line and mouse primary microglia from wt and P2rx7-deleted mice to test the effect of nimodipine on amyloid beta (Abeta)-dependent NLRP3 inflammasome expression and function, and on mitochondrial energy metabolism.	Nimodipine	139-149	NLR family, pyrin domain containing 3	Mus musculus	184-189
30716318-8	2019	In addition, immunohistochemistry staining and western blot analysis indicated that harmine treatment suppressed the expression of toll-like receptor 4 (TLR4) and the phosphorylation of nuclear factor-kappa B (NF-kappaB) p65 and inhibitor of kappaBalpha (IkappaBalpha) while inhibiting the expression of NLRP3, caspase-1 and interleukin-1beta (IL-1beta).	Harmine	84-91	NLR family, pyrin domain containing 3	Mus musculus	304-309
30716318-10	2019	The involved underlying mechanisms of harmine in LPS-induced acute kidney injury might be related to inhibition of the TLR4-NF-kappaB pathway and NLRP3 inflammasome pathway.	Harmine	38-45	NLR family, pyrin domain containing 3	Mus musculus	146-151
30796460-6	2019	Selective inhibition of the IRE-1alpha/XBP-1s branch by a pharmacological inhibitor STF-083010 or by genetic silencing of XBP-1 significantly attenuated Cd-induced NLRP3 inflammasome activation and pyroptosis.	STF 083010	84-94	NLR family, pyrin domain containing 3	Mus musculus	164-169
31097920-7	2019	In addition, after blocking CD36 with inhibitor sulfo-N-succinimidyl oleate (SSO) or CD36 siRNA, activation of NLRP3 inflammasome and release of IL-1beta are downregulated, and podocyte injury was alleviated.	sulfo-N-succinimidyl oleate	48-75	NLR family, pyrin domain containing 3	Mus musculus	111-116
31097920-7	2019	In addition, after blocking CD36 with inhibitor sulfo-N-succinimidyl oleate (SSO) or CD36 siRNA, activation of NLRP3 inflammasome and release of IL-1beta are downregulated, and podocyte injury was alleviated.	sulfo-N-succinimidyl oleate	77-80	NLR family, pyrin domain containing 3	Mus musculus	111-116
30796460-3	2019	Human proximal tubular epithelial HK-2 cells were treated with 0-10 microM CdCl2 for 48 h. We found that Cd dose-dependently caused cytotoxicity, which correlated with activation of the NLRP3 inflammasome, increases in the expression and secretion of pro-inflammatory cytokines and upregulation of pyroptosis-related genes in HK-2 cells or/and in kidneys of Cd-treated mice.	Cadmium Chloride	75-80	NLR family, pyrin domain containing 3	Mus musculus	186-191
30796460-3	2019	Human proximal tubular epithelial HK-2 cells were treated with 0-10 microM CdCl2 for 48 h. We found that Cd dose-dependently caused cytotoxicity, which correlated with activation of the NLRP3 inflammasome, increases in the expression and secretion of pro-inflammatory cytokines and upregulation of pyroptosis-related genes in HK-2 cells or/and in kidneys of Cd-treated mice.	Cadmium	75-77	NLR family, pyrin domain containing 3	Mus musculus	186-191
30971058-3	2019	The NLRP3 inflammasome was activated in BV2 microglia cells to explore potential mechanisms for the neuroprotective effects of Asiatic acid.	asiatic acid	127-139	NLR family, pyrin domain containing 3	Mus musculus	4-9
30971286-0	2019	Microglial NLRP3 inflammasome activation mediates IL-1beta release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model.	Nitroglycerin	123-136	NLR family, pyrin domain containing 3	Mus musculus	11-16
30971286-9	2019	RESULTS: Repeated NTG administration induced acute and chronic mechanical hyperalgesia and increased expression of NLRP3 and IL-1beta.	Nitroglycerin	18-21	NLR family, pyrin domain containing 3	Mus musculus	115-120
30971286-10	2019	Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC.	Nitroglycerin	38-41	NLR family, pyrin domain containing 3	Mus musculus	12-17
30971286-10	2019	Blockade of NLRP3 or IL-1beta reduced NTG-induced hyperalgesia, and this effect was accompanied by a significant inhibition of the NTG-induced increase in p-ERK, c-Fos and CGRP levels in the TNC.	Nitroglycerin	131-134	NLR family, pyrin domain containing 3	Mus musculus	12-17
30952839-4	2019	Furthermore, Lico A efficiently alleviated LPS-induced inflammatory response by inhibiting TLR4-MAPK and -NF-kappaB, as well as the Txnip-NLRP3 signaling pathway.	licochalcone A	13-19	NLR family, pyrin domain containing 3	Mus musculus	138-143
30944389-0	2019	Glucosamine inhibits IL-1beta expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome.	Glucosamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	110-115
30944389-3	2019	Glucosamine is widely used as a dietary supplement to promote the health of cartilage tissue and is expected to exert anti-inflammatory activity in joint inflammation, which is a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome-associated complication.	Glucosamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	179-260
30944389-3	2019	Glucosamine is widely used as a dietary supplement to promote the health of cartilage tissue and is expected to exert anti-inflammatory activity in joint inflammation, which is a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome-associated complication.	Glucosamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	262-267
30944389-4	2019	Here, we investigated whether GlcN inhibits the NLRP3 inflammasome and dissected the underlying molecular mechanisms.	Glucosamine	30-34	NLR family, pyrin domain containing 3	Mus musculus	48-53
30944389-5	2019	We found that GlcN suppressed the NLRP3 inflammasome in mouse and human macrophages.	Glucosamine	14-18	NLR family, pyrin domain containing 3	Mus musculus	34-39
30944389-10	2019	These results indicated that GlcN might be a novel dietary supplement for the amelioration of NLRP3 inflammasome-associated complications.	Glucosamine	29-33	NLR family, pyrin domain containing 3	Mus musculus	94-99
30796460-3	2019	Human proximal tubular epithelial HK-2 cells were treated with 0-10 microM CdCl2 for 48 h. We found that Cd dose-dependently caused cytotoxicity, which correlated with activation of the NLRP3 inflammasome, increases in the expression and secretion of pro-inflammatory cytokines and upregulation of pyroptosis-related genes in HK-2 cells or/and in kidneys of Cd-treated mice.	Cadmium	105-107	NLR family, pyrin domain containing 3	Mus musculus	186-191
30796460-4	2019	These effects were significantly abrogated by inhibiting caspase-1 activity with inhibitor YVAD or silencing NLRP3 with siRNA in vitro, suggesting that Cd induces caspase-1- and NLRP3-inflammasome-dependent pyroptosis.	Cadmium	152-154	NLR family, pyrin domain containing 3	Mus musculus	109-114
30796460-4	2019	These effects were significantly abrogated by inhibiting caspase-1 activity with inhibitor YVAD or silencing NLRP3 with siRNA in vitro, suggesting that Cd induces caspase-1- and NLRP3-inflammasome-dependent pyroptosis.	Cadmium	152-154	NLR family, pyrin domain containing 3	Mus musculus	178-183
30796460-6	2019	Selective inhibition of the IRE-1alpha/XBP-1s branch by a pharmacological inhibitor STF-083010 or by genetic silencing of XBP-1 significantly attenuated Cd-induced NLRP3 inflammasome activation and pyroptosis.	Cadmium	153-155	NLR family, pyrin domain containing 3	Mus musculus	164-169
30653357-6	2019	Moreover, upon inflammatory stimuli, including ATP and nigericin treatments, CUL1 disassociates from NLRP3 to release the repression of the NLRP3 inflammasome.	Adenosine Triphosphate	47-50	NLR family, pyrin domain containing 3	Mus musculus	101-106
30859754-0	2019	Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.	Glyburide	0-13	NLR family, pyrin domain containing 3	Mus musculus	133-138
30859754-13	2019	Glibenclamide treatment and NLRP3 knockdown significantly reduced hemin-induced activation of the NLRP3 inflammasome, release of extracellular lactate dehydrogenase, apoptosis, and loss of ZO-1 in b.End3 cells.	Glyburide	0-13	NLR family, pyrin domain containing 3	Mus musculus	98-103
30859754-13	2019	Glibenclamide treatment and NLRP3 knockdown significantly reduced hemin-induced activation of the NLRP3 inflammasome, release of extracellular lactate dehydrogenase, apoptosis, and loss of ZO-1 in b.End3 cells.	Hemin	66-71	NLR family, pyrin domain containing 3	Mus musculus	28-33
30859754-13	2019	Glibenclamide treatment and NLRP3 knockdown significantly reduced hemin-induced activation of the NLRP3 inflammasome, release of extracellular lactate dehydrogenase, apoptosis, and loss of ZO-1 in b.End3 cells.	Hemin	66-71	NLR family, pyrin domain containing 3	Mus musculus	98-103
30859754-14	2019	However, NLRP3 knockdown abolished the protective effect of glibenclamide.	Glyburide	60-73	NLR family, pyrin domain containing 3	Mus musculus	9-14
30859754-15	2019	CONCLUSION: Glibenclamide maintained BBB integrity in experimental ICH by inhibiting the activation of the NLRP3 inflammasome in microvessel endothelial cells.	Glyburide	12-25	NLR family, pyrin domain containing 3	Mus musculus	107-112
30707890-0	2019	NLRP3 inflammasome in NMDA-induced retinal excitotoxicity.	N-Methylaspartate	22-26	NLR family, pyrin domain containing 3	Mus musculus	0-5
30707890-3	2019	Thus far, it has not been elucidated whether NMDA-mediated excitotoxicity can trigger NLRP3 inflammasome in vivo.	N-Methylaspartate	45-49	NLR family, pyrin domain containing 3	Mus musculus	86-91
30707890-6	2019	NMDA insult in the retina potentiates macrophage/microglia cell infiltration, primes the NLRP3 inflammasome in a transcription-dependent manner and induces the expression of interleukin-1beta (IL-1beta).	N-Methylaspartate	0-4	NLR family, pyrin domain containing 3	Mus musculus	89-94
30707890-9	2019	Our results indicate that NMDA-mediated retinal excitotoxicity induces immune cell recruitment and NLRP3 inflammasome activity even though inflammasome-mediated neuroinflammation is not a leading contributing factor to cell death in this type of retinal injury.	N-Methylaspartate	26-30	NLR family, pyrin domain containing 3	Mus musculus	99-104
30615919-0	2019	5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson"s disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress.	CHEMBL4291418	0-64	NLR family, pyrin domain containing 3	Mus musculus	209-214
30653357-6	2019	Moreover, upon inflammatory stimuli, including ATP and nigericin treatments, CUL1 disassociates from NLRP3 to release the repression of the NLRP3 inflammasome.	Adenosine Triphosphate	47-50	NLR family, pyrin domain containing 3	Mus musculus	140-145
30653357-6	2019	Moreover, upon inflammatory stimuli, including ATP and nigericin treatments, CUL1 disassociates from NLRP3 to release the repression of the NLRP3 inflammasome.	Nigericin	55-64	NLR family, pyrin domain containing 3	Mus musculus	101-106
30653357-6	2019	Moreover, upon inflammatory stimuli, including ATP and nigericin treatments, CUL1 disassociates from NLRP3 to release the repression of the NLRP3 inflammasome.	Nigericin	55-64	NLR family, pyrin domain containing 3	Mus musculus	140-145
30716587-6	2019	Intraperitoneal injection of fraxinellone significantly inhibited the pancreatic activation of multiple inflammasome molecules such as NACHT, LRR and PYD domains-containing protein 3 (NLRP3), PY-CARD, caspase-1, IL-18, and IL-1beta during AP.	fraxinellone	29-41	NLR family, pyrin domain containing 3	Mus musculus	184-189
31084401-0	2019	Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition.	madecassoside	33-46	NLR family, pyrin domain containing 3	Mus musculus	110-115
31084401-7	2019	Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation.	madecassoside	13-26	NLR family, pyrin domain containing 3	Mus musculus	94-99
31084401-7	2019	Furthermore, Madecassoside decreased MSU-induced neutrophil cytosolic factor 1, caspase-1 and NLRP3 expression in mice with peritoneal inflammation.	Uric Acid	37-40	NLR family, pyrin domain containing 3	Mus musculus	94-99
31084401-10	2019	Conclusion: These findings indicate that Madecassoside has potential to ameliorate inflammation in both acute gouty arthritis model and peritonitis model, probably via regulating IL-1beta and NLRP3 expression.	madecassoside	41-54	NLR family, pyrin domain containing 3	Mus musculus	192-197
30343389-10	2019	TQ inhibited plasma cTnT levels; improved ATP; significantly inhibited p62, NLRP3, caspase-1, IL-1beta, IL-18, IL-6, TNF-alpha, and MCP-1expressions; and increased beclin 1 and IL-10 level.	thymoquinone	0-2	NLR family, pyrin domain containing 3	Mus musculus	76-81
30738291-0	2019	Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	48-53
30738291-11	2019	In addition, curcumin reduced NLRP3 inflammasome activation in lupus-prone mice.	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	30-35
30051350-0	2019	The Involvement of NLRP3 on the Effects of Minocycline in an AD-Like Pathology Induced by beta-Amyloid Oligomers Administered to Mice.	Minocycline	43-54	NLR family, pyrin domain containing 3	Mus musculus	19-24
30738291-12	2019	In vitro, curcumin significantly inhibited anti-dsDNA+ serum induced expression of NLRP3 inflammasome in podocytes.	Curcumin	10-18	NLR family, pyrin domain containing 3	Mus musculus	83-88
30747785-0	2019	The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.	dapansutrile	34-41	NLR family, pyrin domain containing 3	Mus musculus	4-9
30747785-0	2019	The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.	dapansutrile	43-55	NLR family, pyrin domain containing 3	Mus musculus	4-9
30747785-3	2019	We proposed that OLT1177 (dapansutrile), a novel NLRP3 inflammasome inhibitor, could preserve myocardial function after ischemia reperfusion injury in the mouse.	dapansutrile	26-38	NLR family, pyrin domain containing 3	Mus musculus	49-54
30256406-8	2019	The 2-DG treatment also strongly suppressed the activation of the NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome.	Deoxyglucose	4-8	NLR family, pyrin domain containing 3	Mus musculus	136-141
30256406-10	2019	We found that the 2-DG treatment remarkably reduced the expression of proinflammatory factors induced by LPS, including tumor necrosis factor-alpha messenger RNA (mRNA), pro-interleukin (IL)-1beta mRNA, pro-IL-18 mRNA, NLRP3 mRNA, caspase-1 mRNA, and IL-1beta protein.	Deoxyglucose	18-22	NLR family, pyrin domain containing 3	Mus musculus	219-224
30782961-3	2019	Several studies in hyperlipidemic mouse models found that the NOD-like receptor protein 3 (NLRP3) inflammasome contributes to atherosclerosis, but recent work suggests that a second hit, such as defective cholesterol efflux or accumulation of oxidized mitochondrial DNA, may be required for significant inflammasome activation.	Cholesterol	205-216	NLR family, pyrin domain containing 3	Mus musculus	62-89
30782961-3	2019	Several studies in hyperlipidemic mouse models found that the NOD-like receptor protein 3 (NLRP3) inflammasome contributes to atherosclerosis, but recent work suggests that a second hit, such as defective cholesterol efflux or accumulation of oxidized mitochondrial DNA, may be required for significant inflammasome activation.	Cholesterol	205-216	NLR family, pyrin domain containing 3	Mus musculus	91-96
30051350-12	2019	Thus, the anti-inflammatory effect of minocycline involves TLR2 receptors and NLRP3, besides being beneficial by ameliorating memory impairments.	Minocycline	38-49	NLR family, pyrin domain containing 3	Mus musculus	78-83
30632500-11	2019	Our findings indicate that acacetin has a protective effect on cerebral ischemia-reperfusion injury, and its mechanism of action is associated with inhibition of microglia-mediated inflammation and the NLRP3 signaling pathway.	acacetin	27-35	NLR family, pyrin domain containing 3	Mus musculus	202-207
30632500-0	2019	Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway.	acacetin	0-8	NLR family, pyrin domain containing 3	Mus musculus	71-76
30607478-11	2019	At a molecular level, RSV inhibited the activation of NLRP3 and NF-kappaB in the hippocampal region caused by deficiency of estrogen.	Resveratrol	22-25	NLR family, pyrin domain containing 3	Mus musculus	54-59
30632500-2	2019	However, whether acacetin has an effect on inflammatory corpuscle 3 (NLRP3) after cerebral ischemia-reperfusion injury has not been fully determined.	acacetin	17-25	NLR family, pyrin domain containing 3	Mus musculus	69-74
31182921-0	2019	Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	23-28
30357309-0	2019	Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.	Salts	110-114	NLR family, pyrin domain containing 3	Mus musculus	34-39
30357309-9	2019	MCC950 treatment from day 10 attenuated 1K/DOCA/salt-induced increases in renal expression of inflammasome subunits (NLRP3, ASC, pro-caspase-1) and inflammatory/injury markers (pro-IL-18, pro-IL-1beta, IL-17A, TNF-alpha, osteopontin, ICAM-1, VCAM-1, CCL2, vimentin), each by 25-40%.	Desoxycorticosterone Acetate	43-47	NLR family, pyrin domain containing 3	Mus musculus	117-122
30357309-9	2019	MCC950 treatment from day 10 attenuated 1K/DOCA/salt-induced increases in renal expression of inflammasome subunits (NLRP3, ASC, pro-caspase-1) and inflammatory/injury markers (pro-IL-18, pro-IL-1beta, IL-17A, TNF-alpha, osteopontin, ICAM-1, VCAM-1, CCL2, vimentin), each by 25-40%.	Salts	48-52	NLR family, pyrin domain containing 3	Mus musculus	117-122
30971927-0	2019	Evodiamine Augments NLRP3 Inflammasome Activation and Anti-bacterial Responses Through Inducing alpha-Tubulin Acetylation.	evodiamine	0-10	NLR family, pyrin domain containing 3	Mus musculus	20-25
30971927-2	2019	Here we aimed to explore whether evodiamine influenced NLRP3 (NLR family, pyrin containing domain 3) inflammasome activation in macrophages, which is a critical mechanism for defending the host against pathogenic infections.	evodiamine	33-43	NLR family, pyrin domain containing 3	Mus musculus	55-60
30971927-3	2019	We uncovered that evodiamine dose-dependently enhanced NLRP3 inflammasome activation in lipopolysaccharide-primed macrophages, as indicated by increased interleukin (IL)-1beta production and caspase-1 cleavage, accompanied by increased ASC speck formation and pyroptosis.	evodiamine	18-28	NLR family, pyrin domain containing 3	Mus musculus	55-60
30971927-5	2019	Such evodiamine-mediated increases in NLRP3 activation and pyroptosis were attenuated by activators of alpha-tubulin deacetylase, resveratrol and NAD+, or dynein-specific inhibitor ciliobrevin A.	evodiamine	5-15	NLR family, pyrin domain containing 3	Mus musculus	38-43
30971927-5	2019	Such evodiamine-mediated increases in NLRP3 activation and pyroptosis were attenuated by activators of alpha-tubulin deacetylase, resveratrol and NAD+, or dynein-specific inhibitor ciliobrevin A.	Resveratrol	130-141	NLR family, pyrin domain containing 3	Mus musculus	38-43
30971927-5	2019	Such evodiamine-mediated increases in NLRP3 activation and pyroptosis were attenuated by activators of alpha-tubulin deacetylase, resveratrol and NAD+, or dynein-specific inhibitor ciliobrevin A.	NAD	146-150	NLR family, pyrin domain containing 3	Mus musculus	38-43
30971927-6	2019	Small interfering RNA knockdown of alphaTAT1 (the gene encoding alpha-tubulin N-acetyltransferase) expression, which reduced alpha-tubulin acetylation, also diminished evodiamine-mediated augmentation of NLRP3 activation and pyroptosis.	evodiamine	168-178	NLR family, pyrin domain containing 3	Mus musculus	204-209
30971927-7	2019	Evodiamine also enhanced NLRP3-mediated production of IL-1beta and neutrophil recruitment in vivo.	evodiamine	0-10	NLR family, pyrin domain containing 3	Mus musculus	25-30
30971927-10	2019	Collectively, our results indicated that evodiamine augmented the NLRP3 inflammasome activation through inducing alpha-tubulin acetylation, thereby conferring intensified innate immunity against bacterial infection.	evodiamine	41-51	NLR family, pyrin domain containing 3	Mus musculus	66-71
31182921-6	2019	The aim of this study was to investigate whether metformin can inhibit the NLRP3 inflammasome by activating the AMPK/mTOR pathway in DCM.	Metformin	49-58	NLR family, pyrin domain containing 3	Mus musculus	75-80
31182921-8	2019	Immunohistochemical staining, immunofluorescence staining and western blot assays indicated that the expression levels of mTOR, NLRP3, caspase-1, IL-1beta and GSDMD-N were decreased in the diabetic model treated with metformin and were reversed after the administration of an AMPK inhibitor in vivo and in vitro.	gsdmd-n	159-166	NLR family, pyrin domain containing 3	Mus musculus	128-133
30964190-0	2019	Therapeutic effect of dexmedetomidine on intracerebral hemorrhage via regulating NLRP3.	Dexmedetomidine	22-37	NLR family, pyrin domain containing 3	Mus musculus	81-86
30597306-8	2019	In summary, our investigations suggested that the ability of AGD to ameliorate LPS/GalN-induced ALI may involve the inhibition of the NLRP3 inflammasome and NF-kappaB signalling pathways and the upregulation of the Nrf2/NQO1 signalling pathway.	Galactosamine	83-87	NLR family, pyrin domain containing 3	Mus musculus	134-139
30385134-0	2019	Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway.	puerarin	0-8	NLR family, pyrin domain containing 3	Mus musculus	99-104
30592629-0	2019	Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation.	Brefeldin A	0-11	NLR family, pyrin domain containing 3	Mus musculus	66-71
30592629-2	2019	Here, we found that perturbation of ER-Golgi trafficking by brefeldin A (BFA) treatment attenuated nucleotide-binding oligomerization domain-like receptor family, pyrin-domain-containing 3 (NLRP3) inflammasome activation in mouse bone marrow-derived macrophages (BMDMs).	Brefeldin A	60-71	NLR family, pyrin domain containing 3	Mus musculus	99-188
30592629-2	2019	Here, we found that perturbation of ER-Golgi trafficking by brefeldin A (BFA) treatment attenuated nucleotide-binding oligomerization domain-like receptor family, pyrin-domain-containing 3 (NLRP3) inflammasome activation in mouse bone marrow-derived macrophages (BMDMs).	Brefeldin A	60-71	NLR family, pyrin domain containing 3	Mus musculus	190-195
30592629-2	2019	Here, we found that perturbation of ER-Golgi trafficking by brefeldin A (BFA) treatment attenuated nucleotide-binding oligomerization domain-like receptor family, pyrin-domain-containing 3 (NLRP3) inflammasome activation in mouse bone marrow-derived macrophages (BMDMs).	Brefeldin A	73-76	NLR family, pyrin domain containing 3	Mus musculus	99-188
30592629-2	2019	Here, we found that perturbation of ER-Golgi trafficking by brefeldin A (BFA) treatment attenuated nucleotide-binding oligomerization domain-like receptor family, pyrin-domain-containing 3 (NLRP3) inflammasome activation in mouse bone marrow-derived macrophages (BMDMs).	Brefeldin A	73-76	NLR family, pyrin domain containing 3	Mus musculus	190-195
30592629-3	2019	BFA treatment inhibited NLRP3-mediated inflammasome assembly and caspase-1 activation but did not block IL-1beta secretion from BMDMs following BFA administration after NLRP3 inflammasome activation.	Brefeldin A	0-3	NLR family, pyrin domain containing 3	Mus musculus	24-29
30592629-7	2019	These data suggest that BFA-targeted vesicle trafficking at the Golgi contributes to activation of the NLRP3 inflammasome signaling.-Hong, S., Hwang, I., Gim, E., Yang, J., Park, S., Yoon, S.-H., Lee, W.-W., Yu, J.-W. Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation.	Brefeldin A	24-27	NLR family, pyrin domain containing 3	Mus musculus	103-108
30592629-7	2019	These data suggest that BFA-targeted vesicle trafficking at the Golgi contributes to activation of the NLRP3 inflammasome signaling.-Hong, S., Hwang, I., Gim, E., Yang, J., Park, S., Yoon, S.-H., Lee, W.-W., Yu, J.-W. Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation.	Brefeldin A	24-27	NLR family, pyrin domain containing 3	Mus musculus	284-289
30592629-7	2019	These data suggest that BFA-targeted vesicle trafficking at the Golgi contributes to activation of the NLRP3 inflammasome signaling.-Hong, S., Hwang, I., Gim, E., Yang, J., Park, S., Yoon, S.-H., Lee, W.-W., Yu, J.-W. Brefeldin A-sensitive ER-Golgi vesicle trafficking contributes to NLRP3-dependent caspase-1 activation.	Brefeldin A	218-229	NLR family, pyrin domain containing 3	Mus musculus	103-108
30385134-7	2019	In addition, changes in the Nlrp3 inflammasome activation via reactive oxygen species (ROS)-dependent oxidative pathway were investigated using western blot, immunofluorescence microscopy analyses and flow cytometry.	Reactive Oxygen Species	62-85	NLR family, pyrin domain containing 3	Mus musculus	28-33
30385134-7	2019	In addition, changes in the Nlrp3 inflammasome activation via reactive oxygen species (ROS)-dependent oxidative pathway were investigated using western blot, immunofluorescence microscopy analyses and flow cytometry.	Reactive Oxygen Species	87-90	NLR family, pyrin domain containing 3	Mus musculus	28-33
30385134-8	2019	ROS scavenger and Nlrp3 gene silencing were used to determine the roles of the ROS-Nlrp3 pathway involved in the molecular mechanism of Pu.	Reactive Oxygen Species	79-82	NLR family, pyrin domain containing 3	Mus musculus	83-88
30385134-9	2019	RESULTS: Our findings demonstrate that puerarin inhibits high glucose-induced Nlrp3 inflammasome formation and activation, as shown by fluorescence confocal microscopy and Western blot.	puerarin	39-47	NLR family, pyrin domain containing 3	Mus musculus	78-83
30385134-9	2019	RESULTS: Our findings demonstrate that puerarin inhibits high glucose-induced Nlrp3 inflammasome formation and activation, as shown by fluorescence confocal microscopy and Western blot.	Glucose	62-69	NLR family, pyrin domain containing 3	Mus musculus	78-83
30385134-12	2019	Interestingly, thioredoxin-interacting protein (TXNIP) protein and TXNIP binding to Nlrp3 markedly decreased with puerarin treatment.	puerarin	114-122	NLR family, pyrin domain containing 3	Mus musculus	84-89
30385134-16	2019	In conclusion, we reveal a new protection mechanism of puerarin that inhibits Nlrp3 inflammasome activation and decreases subsequent caspase-1 activation, triggering the release of HMGB1 by reducing ROS generation.	puerarin	55-63	NLR family, pyrin domain containing 3	Mus musculus	78-83
30576854-5	2019	The cationic CNCs-poly(APMA) evoked a more robust immunological response in murine cell line, while the anionic CNCs-poly(NIPAAm) showed a significant NLRP3 inflammasome-dependent and independent immunological response in human monocytes.	nipaam	122-128	NLR family, pyrin domain containing 3	Mus musculus	151-156
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	0-10	NLR family, pyrin domain containing 3	Mus musculus	36-41
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	0-10	NLR family, pyrin domain containing 3	Mus musculus	184-189
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	141-151	NLR family, pyrin domain containing 3	Mus musculus	36-41
30937316-15	2019	Budesonide significantly suppressed NLRP3 and pro-caspase-1 expression in the lung and reduced IL-1beta content in the BALF, indicating that budesonide inhibited the activation of the NLRP3 inflammasome.	Budesonide	141-151	NLR family, pyrin domain containing 3	Mus musculus	184-189
30937316-17	2019	Conclusion: Suppression of NLRP3 inflammasome activation in mice via budesonide attenuated lung injury induced by LPS in mice with ALI.	Budesonide	69-79	NLR family, pyrin domain containing 3	Mus musculus	27-32
30873011-0	2019	The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction.	Reactive Oxygen Species	87-90	NLR family, pyrin domain containing 3	Mus musculus	26-31
30918581-0	2019	Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus.	honokiol	0-8	NLR family, pyrin domain containing 3	Mus musculus	139-144
30918581-2	2019	The activation of NLRP3 inflammasome had been reported to be involved in neurodegenerative diseases, including postoperative cognitive change, and is closely related to mitochondrial ROS and mitophagy.	ros	183-186	NLR family, pyrin domain containing 3	Mus musculus	18-23
30918581-10	2019	Honokiol-mediated mitophagy inhibited the activation of NLRP3 inflammasome and neuroinflammation in the hippocampus.	honokiol	0-8	NLR family, pyrin domain containing 3	Mus musculus	56-61
30918581-11	2019	Using 3-MA, an autophagy inhibitor, the neuroprotective effects of HNK on mitophagy and NLRP3 inflammasome activation were eliminated.	3-methyladenine	6-10	NLR family, pyrin domain containing 3	Mus musculus	88-93
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	Reactive Oxygen Species	53-76	NLR family, pyrin domain containing 3	Mus musculus	163-206
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	Reactive Oxygen Species	53-76	NLR family, pyrin domain containing 3	Mus musculus	208-213
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	NLR family, pyrin domain containing 3	Mus musculus	163-206
30873011-4	2019	Growing evidence has shown that mitochondria-derived reactive oxygen species (mtROS) are closely linked to IL-1beta expression through a redox sensor known as the nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome.	mtros	78-83	NLR family, pyrin domain containing 3	Mus musculus	208-213
30867846-11	2019	Conclusions: p66Shc is a key regulator of liver fibrosis by mediating mitochondrial ROS production, which triggers NLRP3 inflammasome activation.	Reactive Oxygen Species	84-87	NLR family, pyrin domain containing 3	Mus musculus	115-120
30741293-6	2019	Interestingly, further investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) expression and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element-binding protein (CREB) in hippocampal.	cums	70-74	NLR family, pyrin domain containing 3	Mus musculus	140-167
30741293-6	2019	Interestingly, further investigations demonstrated that SEC inhibited CUMS-induced activation of the nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasomes pathways but upregulated brain-derived neurotrophic factor (BDNF) expression and promoted phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element-binding protein (CREB) in hippocampal.	cums	70-74	NLR family, pyrin domain containing 3	Mus musculus	169-174
30899381-0	2019	SXBX pill suppresses homocysteine-induced vascular smooth muscle cells dedifferentiation by inhibiting NLRP3 inflammasomes activation via ERK/p38 MAPK pathways.	Homocysteine	21-33	NLR family, pyrin domain containing 3	Mus musculus	103-108
30779140-3	2019	Herein, we investigated the anti-inflammatory effects of metformin on the NIMA-related kinase 7(Nek7)/NOD-like receptor family pyrin domain containing 3 (NLRP3) pathway both in vivo and in vitro in experimental diabetic periodontitis.	Metformin	57-66	NLR family, pyrin domain containing 3	Mus musculus	154-159
30779140-13	2019	Furthermore, after stimulation with the mTOR inhibitor rapamycin, additional metformin treatment could still downregulate Nek7/NLRP3.	Metformin	77-86	NLR family, pyrin domain containing 3	Mus musculus	127-132
30779140-15	2019	Metformin suppressed the inflammatory state by inhibiting Nek7 expression to decrease NLRP3 inflammasome activity.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	86-91
30899381-12	2019	In conclusion, SXBX pill inhibited Hcy-induced proliferation, migration and dedifferentiation of VSMCs by suppressing NLRP3 inflammasomes activation via of ERK/p38 MAPK pathway.	Homocysteine	35-38	NLR family, pyrin domain containing 3	Mus musculus	118-123
30594691-0	2019	Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination.	myricetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	19-24
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	myricetin	29-38	NLR family, pyrin domain containing 3	Mus musculus	49-54
30594691-0	2019	Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination.	myricetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	135-140
30594691-0	2019	Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination.	Reactive Oxygen Species	66-69	NLR family, pyrin domain containing 3	Mus musculus	19-24
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	myricetin	29-38	NLR family, pyrin domain containing 3	Mus musculus	154-159
30594691-0	2019	Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination.	Reactive Oxygen Species	119-122	NLR family, pyrin domain containing 3	Mus musculus	19-24
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	myricetin	29-38	NLR family, pyrin domain containing 3	Mus musculus	154-159
30389578-2	2019	Extracellular heme, with its pro-oxidant, pro-inflammatory and cytotoxic effects, is sensed by innate immune cells through pattern recognition receptors such as toll-like receptor 4 and nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3), while free availability of heme is strictly controlled.	Heme	14-18	NLR family, pyrin domain containing 3	Mus musculus	282-287
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	Reactive Oxygen Species	94-117	NLR family, pyrin domain containing 3	Mus musculus	49-54
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	Reactive Oxygen Species	119-122	NLR family, pyrin domain containing 3	Mus musculus	49-54
30594691-3	2019	The present study found that myricetin inhibited NLRP3 inflammasome assembly via promotion of reactive oxygen species (ROS)-independent ubiquitination of NLRP3 and reduction of ROS-dependent ubiquitination of ASC (apoptosis-associated speck-like protein containing a CARD), which disrupted the interaction between ASC and NLRP3 and inhibited ASC oligomerization.	Reactive Oxygen Species	177-180	NLR family, pyrin domain containing 3	Mus musculus	49-54
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	NLR family, pyrin domain containing 3	Mus musculus	114-119
30554117-0	2019	Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-kappaB and NLRP3 inflammasome.	evodiamine	0-10	NLR family, pyrin domain containing 3	Mus musculus	115-120
30554117-6	2019	Further mechanistic results showed that EVO restrained the inflammation by regulating NF-kappaB signal and NLRP3 inflammasome.	evodiamine	40-43	NLR family, pyrin domain containing 3	Mus musculus	107-112
30554117-0	2019	Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-kappaB and NLRP3 inflammasome.	Dextran Sulfate	20-42	NLR family, pyrin domain containing 3	Mus musculus	115-120
30180270-8	2019	Stimulated WT HSCs displayed increased levels of NLRP3 inflammasome-induced reactive oxygen species (ROS) production and cathepsin B activity, accompanied by an up-regulation of mRNA and protein levels of fibrotic makers, an effect abrogated in Nlrp3-/- HSCs.	Reactive Oxygen Species	76-99	NLR family, pyrin domain containing 3	Mus musculus	49-54
30180270-8	2019	Stimulated WT HSCs displayed increased levels of NLRP3 inflammasome-induced reactive oxygen species (ROS) production and cathepsin B activity, accompanied by an up-regulation of mRNA and protein levels of fibrotic makers, an effect abrogated in Nlrp3-/- HSCs.	Reactive Oxygen Species	101-104	NLR family, pyrin domain containing 3	Mus musculus	49-54
30180270-9	2019	Nlrp3L351P CreT HSCs also showed elevated mRNA and protein expression of fibrotic markers 24 hours after inflammasome activation induced with 4-hydroxytamoxifen (4OHT).	hydroxytamoxifen	142-160	NLR family, pyrin domain containing 3	Mus musculus	0-5
30774010-0	2019	The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in Nod2 knockout mice.	dss	32-35	NLR family, pyrin domain containing 3	Mus musculus	4-9
30276509-9	2019	In addition, administration of MCC950 or Ac-YVAD-CMK rescues cognitive deficits and ameliorates increased hippocampal NLRP3-mediated neuronal pyroptosis and pro-inflammatory cytokines.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	31-37	NLR family, pyrin domain containing 3	Mus musculus	118-123
30276509-9	2019	In addition, administration of MCC950 or Ac-YVAD-CMK rescues cognitive deficits and ameliorates increased hippocampal NLRP3-mediated neuronal pyroptosis and pro-inflammatory cytokines.	ac-yvad	41-48	NLR family, pyrin domain containing 3	Mus musculus	118-123
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dextran sodium sulfate	126-148	NLR family, pyrin domain containing 3	Mus musculus	69-106
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dextran sodium sulfate	126-148	NLR family, pyrin domain containing 3	Mus musculus	108-113
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dss	150-153	NLR family, pyrin domain containing 3	Mus musculus	69-106
30537634-7	2019	The elevated levels of nod-like receptor protein 3 (NLRP3) inflammasome in hippocampus of d-gal-treated mice were reduced by PF11 through reducing the accumulation of advanced glycation endproducts (AGEs) and the expression of the receptor of advanced glycation endproducts (RAGE).	Galactose	90-95	NLR family, pyrin domain containing 3	Mus musculus	23-50
30537634-7	2019	The elevated levels of nod-like receptor protein 3 (NLRP3) inflammasome in hippocampus of d-gal-treated mice were reduced by PF11 through reducing the accumulation of advanced glycation endproducts (AGEs) and the expression of the receptor of advanced glycation endproducts (RAGE).	Galactose	90-95	NLR family, pyrin domain containing 3	Mus musculus	52-57
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dss	150-153	NLR family, pyrin domain containing 3	Mus musculus	108-113
30774010-5	2019	NLRP3 inflammasome formation was observed at a higher rate in NOD2-deficient small intestinal lamina propria cells after insult by DSS.	dss	131-134	NLR family, pyrin domain containing 3	Mus musculus	0-5
30515710-15	2019	Finally, allicin supplementation inhibited the Nucleotide-binding oligomerization domain containing 3 (NLRP3) inflammasome hyperactivity, and the expressions of inflammasome components, such as ACS, caspase-1, and IL-1beta in the hippocampus of CSDS mice.	allicin	9-16	NLR family, pyrin domain containing 3	Mus musculus	103-108
30557824-3	2019	In this study, we found that rapamycin ameliorated LPS-induced ALI by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated IL-1beta and IL-18 secretion.	Sirolimus	29-38	NLR family, pyrin domain containing 3	Mus musculus	133-138
30515710-0	2019	Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.	allicin	0-7	NLR family, pyrin domain containing 3	Mus musculus	105-110
30515710-16	2019	Allicin attenuated depressive-like behaviors of CSDS mice through reducing neuroinflammation, ameliorating iron abnromal accumulation, balacing oxidative stress, and attenuation neuronal apoptosis in the hippocampus via suppression of NLRP3 inflammasome.	allicin	0-7	NLR family, pyrin domain containing 3	Mus musculus	235-240
30610999-0	2019	Electroacupuncture at ST-36 ameliorates DSS-induced acute colitis via regulating macrophage polarization induced by suppressing NLRP3/IL-1beta and promoting Nrf2/HO-1.	Dextran Sulfate	40-43	NLR family, pyrin domain containing 3	Mus musculus	128-133
30610999-12	2019	(4) NLRP3/IL-1beta protein and mRNA levels in isolated macrophages decreased with HEA and LEA compared with the DSS treatment group; (5) HEA increased Nrf2/HO-1 levels compared with levels in DSS mice.	Dextran Sulfate	112-115	NLR family, pyrin domain containing 3	Mus musculus	4-9
30761140-0	2019	Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages.	Paclitaxel	0-10	NLR family, pyrin domain containing 3	Mus musculus	53-58
30989921-1	2019	The aim of this paper was to study the effect and mechanism of alcohol extract from Polygonum cuspidatum(PCE) on acute gouty arthritis in C57 BL/6 mice through NLRP3/ASC/caspase-1 axis.	Alcohols	63-70	NLR family, pyrin domain containing 3	Mus musculus	160-165
30989921-5	2019	The swelling degree of ankle joint significantly relief; expression of IL-1beta, IL-6 and TNF-alpha in joint synovium significantly decrease; mRNA and protein expression of NLRP3, ASC and caspase-1 were significantly decrease in PCE treatment group compared with model group.	pce	229-232	NLR family, pyrin domain containing 3	Mus musculus	173-178
30989921-6	2019	Our research implied that alcohol extract from P. cuspidatum had positive effect on acute gouty arthritis in mice, and the regulation of NLRP3/ASC/caspase-1 axis may be its mechanism.	Alcohols	26-33	NLR family, pyrin domain containing 3	Mus musculus	137-142
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Paclitaxel	20-30	NLR family, pyrin domain containing 3	Mus musculus	88-93
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Adenosine Triphosphate	62-65	NLR family, pyrin domain containing 3	Mus musculus	88-93
30761140-3	2019	Here we showed that paclitaxel pre-treatment greatly enhanced ATP- or nigericin-induced NLRP3 inflammasome activation as indicated by increased release of cleaved caspase-1 and mature IL-1beta, enhanced formation of ASC speck, and increased gasdermin D cleavage and pyroptosis.	Nigericin	70-79	NLR family, pyrin domain containing 3	Mus musculus	88-93
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Paclitaxel	18-28	NLR family, pyrin domain containing 3	Mus musculus	53-58
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Paclitaxel	18-28	NLR family, pyrin domain containing 3	Mus musculus	253-258
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Resveratrol	115-126	NLR family, pyrin domain containing 3	Mus musculus	53-58
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Resveratrol	115-126	NLR family, pyrin domain containing 3	Mus musculus	253-258
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	NAD	128-132	NLR family, pyrin domain containing 3	Mus musculus	53-58
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Paclitaxel	185-195	NLR family, pyrin domain containing 3	Mus musculus	53-58
30696442-0	2019	NLRP3 deletion inhibits inflammation-driven mouse lung tumorigenesis induced by benzo(a)pyrene and lipopolysaccharide.	Benzo(a)pyrene	80-94	NLR family, pyrin domain containing 3	Mus musculus	0-5
30761140-6	2019	Concurrently, the paclitaxel-mediated enhancement of NLRP3 inflammasome activation was significantly suppressed by resveratrol, NAD+, or MEC-17 knockdown, indicating the involvement of paclitaxel-induced alpha-tubulin acetylation in the augmentation of NLRP3 inflammasome activation.	Paclitaxel	185-195	NLR family, pyrin domain containing 3	Mus musculus	253-258
30761140-7	2019	Similar to paclitaxel, epothilone B that is another microtubule-stabilizing agent also induced alpha-tubulin acetylation and increased NLRP3 inflammasome activation in macrophages in response to ATP treatment.	epothilone B	23-35	NLR family, pyrin domain containing 3	Mus musculus	135-140
30761140-7	2019	Similar to paclitaxel, epothilone B that is another microtubule-stabilizing agent also induced alpha-tubulin acetylation and increased NLRP3 inflammasome activation in macrophages in response to ATP treatment.	Adenosine Triphosphate	195-198	NLR family, pyrin domain containing 3	Mus musculus	135-140
30761140-9	2019	Collectively, our data indicate that paclitaxel potentiated NLRP3 inflammasome activation by inducing alpha-tubulin acetylation and thereby conferred enhanced antibacterial innate responses, suggesting its potential application against pathogenic infections beyond its use as a chemotherapeutic agent.	Paclitaxel	37-47	NLR family, pyrin domain containing 3	Mus musculus	60-65
30805082-2	2019	Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	23-28
30551881-7	2019	Additionally, granisetron could inhibit the activation of p38 MAPK and NLRP3 inflammasome both in vivo and in vitro.	Granisetron	14-25	NLR family, pyrin domain containing 3	Mus musculus	71-76
30604787-7	2019	Phloretin also inhibited the DSS-induced (NOD)-like receptor family and pyrin domain containing 3 (NLRP3) inflammasome activations.	Phloretin	0-9	NLR family, pyrin domain containing 3	Mus musculus	99-104
30604787-7	2019	Phloretin also inhibited the DSS-induced (NOD)-like receptor family and pyrin domain containing 3 (NLRP3) inflammasome activations.	Dextran Sulfate	29-32	NLR family, pyrin domain containing 3	Mus musculus	99-104
30805082-2	2019	Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism.	ros	197-200	NLR family, pyrin domain containing 3	Mus musculus	210-215
30805082-4	2019	Treatment with alpha-lipoic acid, a scavenger of ROS, lowered ROS overproduction and alleviated NLRP3-triggered kidney injury of HFD-treated mice.	Thioctic Acid	15-32	NLR family, pyrin domain containing 3	Mus musculus	96-101
30805082-5	2019	Collectively, the VEGFR2/ROS/NLRP3 signal is a critical therapeutic strategy for the kidney injury of HFD-treated mice.	ros	25-28	NLR family, pyrin domain containing 3	Mus musculus	29-34
30657794-0	2019	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	3-Hydroxybutyric Acid	53-73	NLR family, pyrin domain containing 3	Mus musculus	165-170
30657794-8	2019	In fact, the elevated levels of retinal NLRP3 inflammasome activation markers (NLRP3, ASC, caspase-1) and of the relative proinflammatory cytokines (IL-1beta, IL-18) were significantly reduced by 50 mg/kg and 100 mg/kg beta-hydroxybutyrate treatment.	3-Hydroxybutyric Acid	219-239	NLR family, pyrin domain containing 3	Mus musculus	40-45
30653583-0	2019	Transition from metal-DTH resistance to susceptibility is facilitated by NLRP3 inflammasome signaling induced Th17 reactivity: Implications for orthopedic implants.	metal-dth	16-25	NLR family, pyrin domain containing 3	Mus musculus	73-78
30653583-3	2019	Metal implant debris is known to act as a danger signal that drives NLRP3 inflammasome activation.	Metals	0-5	NLR family, pyrin domain containing 3	Mus musculus	68-73
30653583-7	2019	This study provides mechanistic insight into how in vivo exposure to orthopedic implant debris, and metals in general, elicits NLRP3 inflammasome activation that mediates the generation of IL-17A/F producing CD4+ T cells, leading to metal-delayed type hypersensitivity reactions.	Metals	100-105	NLR family, pyrin domain containing 3	Mus musculus	127-132
30787974-0	2019	Ghrelin attenuates UUO-induced renal fibrosis via attenuation of Nlrp3 inflammasome and endoplasmic reticulum stress.	uuo	19-22	NLR family, pyrin domain containing 3	Mus musculus	65-70
30654511-0	2019	Dual Role of Triptolide in Interrupting the NLRP3 Inflammasome Pathway to Attenuate Cardiac Fibrosis.	triptolide	13-23	NLR family, pyrin domain containing 3	Mus musculus	44-49
30755784-0	2019	Melatonin Alleviates Radiation-Induced Lung Injury via Regulation of miR-30e/NLRP3 Axis.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	77-82
30755784-5	2019	Moreover, in the irradiated RAW 264.7 cells, melatonin blocked the NLRP3 inflammasome activation accompanied with the inhibition of the IL-1beta release and caspase-1 activity.	Melatonin	45-54	NLR family, pyrin domain containing 3	Mus musculus	67-72
30755784-13	2019	Meanwhile, melatonin exerted its protective effect through negatively regulating the NLRP3 inflammasome in macrophages.	Melatonin	11-20	NLR family, pyrin domain containing 3	Mus musculus	85-90
30755784-14	2019	The melatonin-mediated miR-30e/NLRP3 signaling may provide novel therapeutic targets for radiation-induced injury.	Melatonin	4-13	NLR family, pyrin domain containing 3	Mus musculus	31-36
30662948-5	2019	Exaggerated NLRP3 and IL-1beta expression in Vsig4-/- mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	176-198	NLR family, pyrin domain containing 3	Mus musculus	12-17
30626741-8	2019	Viniferin also reduced NLRP3 activation and the production of proinflammatory cytokines, effects that were absent in SIRT3-/- macrophages.	Viniferin	0-9	NLR family, pyrin domain containing 3	Mus musculus	23-28
30662948-5	2019	Exaggerated NLRP3 and IL-1beta expression in Vsig4-/- mice is accountable for deleterious disease severity in experimental autoimmune encephalomyelitis (EAE) and resistance to dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	200-203	NLR family, pyrin domain containing 3	Mus musculus	12-17
30463689-8	2019	In vitro studies revealed that the NLRP3 activator nigericin nullified diallyl sulfide-offered benefit against Akt2 knockout on cardiomyocyte mechanical function and mitophagy (using Western blot and colocalization of GFP-LC3 and MitoTracker Red).	Nigericin	51-60	NLR family, pyrin domain containing 3	Mus musculus	35-40
30522866-6	2019	Genetic ablation of TLR4 in platelets led to decreased platelet caspase 1 activation and platelet aggregation, which was reversed by the NLRP3 activator Nigericin.	Nigericin	153-162	NLR family, pyrin domain containing 3	Mus musculus	137-142
29885849-0	2019	PPARss/delta agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson"s disease.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	85-89	NLR family, pyrin domain containing 3	Mus musculus	32-37
29885849-3	2019	Emerging evidence indicates that the nucleotide-binding domain and leucine-rich-repeat-protein 3 (NLRP3) inflammasome-mediated neuroinflammation plays a crucial role in the pathogenesis of PD.	Leucine	67-74	NLR family, pyrin domain containing 3	Mus musculus	98-103
29885849-4	2019	In the present study we investigate whether PPARss/delta agonists alleviate NLRP3-mediated neuroinflammation in the 1- methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	166-170	NLR family, pyrin domain containing 3	Mus musculus	76-81
29885849-11	2019	Our results show that GW501516 reduced movement impairment in PD mice; furthermore, it attenuated dopaminergic neurodegeneration in the midbrain and the depletion of dopamine in the striatum and it inhibited inflammatory reactions and NLRP3 inflammasome activation in the midbrain of PD mice.	GW 501516	22-30	NLR family, pyrin domain containing 3	Mus musculus	235-240
29885849-13	2019	Collectively, our findings demonstrate for the first time that the specific PPARss/delta agonist GW501516 alleviates NLRP3 inflammasome-mediated neuroinflammation in astrocytes in the MPTP mouse model of PD.	GW 501516	97-105	NLR family, pyrin domain containing 3	Mus musculus	117-122
29885849-13	2019	Collectively, our findings demonstrate for the first time that the specific PPARss/delta agonist GW501516 alleviates NLRP3 inflammasome-mediated neuroinflammation in astrocytes in the MPTP mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	184-188	NLR family, pyrin domain containing 3	Mus musculus	117-122
30522866-7	2019	Two weeks after the induction of FAL, ischemic limb perfusion was increased in TLR4 PF4 and NLRP3-/- mice as compared to control mice.	fal	33-36	NLR family, pyrin domain containing 3	Mus musculus	92-97
30622196-0	2019	Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells.	Manganese	0-9	NLR family, pyrin domain containing 3	Mus musculus	20-25
30622196-3	2019	In this study, we examined whether Mn2+ activates the multiprotein NLRP3 inflammasome complex to promote neuroinflammation.	Manganese(2+)	35-39	NLR family, pyrin domain containing 3	Mus musculus	67-72
30622196-4	2019	Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1beta (IL-1beta).	Manganese(2+)	45-49	NLR family, pyrin domain containing 3	Mus musculus	74-79
30622196-11	2019	Together, these results suggest that the divalent metal manganese acts as a key amplifier of NLRP3 inflammasome signaling and exosomal ASC release.	metal manganese	50-65	NLR family, pyrin domain containing 3	Mus musculus	93-98
30455347-7	2019	RORgamma inverse agonists suppressed lipopolysaccharide (LPS)/ATP-stimulated IL-1beta secretion and expression of Il1b and Nlrp3 in BMDMs.	Adenosine Triphosphate	62-65	NLR family, pyrin domain containing 3	Mus musculus	123-128
30463689-8	2019	In vitro studies revealed that the NLRP3 activator nigericin nullified diallyl sulfide-offered benefit against Akt2 knockout on cardiomyocyte mechanical function and mitophagy (using Western blot and colocalization of GFP-LC3 and MitoTracker Red).	allyl sulfide	71-86	NLR family, pyrin domain containing 3	Mus musculus	35-40
30472522-6	2019	In vitro studies showed that Celastrol reduced the toxicity resulting from the administration of LPS with ATP to BV-2 cells, inhibited the pyroptosis-related proteins (NLRP3 Caspase-1 GSDMD), and inhibited the release of corresponding inflammatory factors.	celastrol	29-38	NLR family, pyrin domain containing 3	Mus musculus	168-173
29786072-0	2019	MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-4	NLR family, pyrin domain containing 3	Mus musculus	12-17
29786072-3	2019	In the present study, we present evidences that microglial NLRP3 inflammasome activation is critical for dopaminergic neuronal loss and the subsequent motor deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	173-217	NLR family, pyrin domain containing 3	Mus musculus	59-64
29786072-3	2019	In the present study, we present evidences that microglial NLRP3 inflammasome activation is critical for dopaminergic neuronal loss and the subsequent motor deficits in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	219-223	NLR family, pyrin domain containing 3	Mus musculus	59-64
29786072-4	2019	Specifically, NLRP3 deficiency significantly reduces motor dysfunctions and dopaminergic neurodegeneration of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	110-114	NLR family, pyrin domain containing 3	Mus musculus	14-19
29786072-5	2019	Furthermore, NLRP3 deficiency abolishes MPTP-induced microglial recruitment, interleukin-1beta production and caspase-1 activation in the SN of mouse brain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	40-44	NLR family, pyrin domain containing 3	Mus musculus	13-18
29786072-6	2019	In primary microglia and mixed glial cell cultures, MPTP/ATP treatment promotes the robust assembly and activation of the NLRP3 inflammasome via producing mitochondrial reactive oxygen species.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	52-56	NLR family, pyrin domain containing 3	Mus musculus	122-127
29786072-6	2019	In primary microglia and mixed glial cell cultures, MPTP/ATP treatment promotes the robust assembly and activation of the NLRP3 inflammasome via producing mitochondrial reactive oxygen species.	Adenosine Triphosphate	57-60	NLR family, pyrin domain containing 3	Mus musculus	122-127
29786072-6	2019	In primary microglia and mixed glial cell cultures, MPTP/ATP treatment promotes the robust assembly and activation of the NLRP3 inflammasome via producing mitochondrial reactive oxygen species.	Oxygen	178-184	NLR family, pyrin domain containing 3	Mus musculus	122-127
29786072-7	2019	Consistently, 1-methyl-4-phenyl-pyridinium (MPP+) induces NLRP3 inflammasome activation in the presence of ATP or nigericin treatment in mouse bone-marrow-derived macrophages.	1-Methyl-4-phenylpyridinium	14-42	NLR family, pyrin domain containing 3	Mus musculus	58-63
29786072-7	2019	Consistently, 1-methyl-4-phenyl-pyridinium (MPP+) induces NLRP3 inflammasome activation in the presence of ATP or nigericin treatment in mouse bone-marrow-derived macrophages.	mangion-purified polysaccharide (Candida albicans)	44-48	NLR family, pyrin domain containing 3	Mus musculus	58-63
29786072-8	2019	These findings reveal a novel priming role of neurotoxin MPTP or MPP+ for NLRP3 activation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	57-61	NLR family, pyrin domain containing 3	Mus musculus	74-79
29786072-8	2019	These findings reveal a novel priming role of neurotoxin MPTP or MPP+ for NLRP3 activation.	mangion-purified polysaccharide (Candida albicans)	65-69	NLR family, pyrin domain containing 3	Mus musculus	74-79
29786072-10	2019	Furthermore, Cx3Cr1CreER-based microglia-specific expression of an active NLRP3 mutant greatly exacerbates motor deficits and dopaminergic neuronal loss of MPTP-treated mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	156-160	NLR family, pyrin domain containing 3	Mus musculus	74-79
29786072-11	2019	Taken together, our results indicate that microglial NLRP3 inflammasome activation plays a pivotal role in the MPTP-induced neurodegeneration in PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	111-115	NLR family, pyrin domain containing 3	Mus musculus	53-58
31266025-1	2019	Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome leading to podocyte dysfunction and glomerular injury.	Homocysteine	23-26	NLR family, pyrin domain containing 3	Mus musculus	63-144
31266025-1	2019	Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome leading to podocyte dysfunction and glomerular injury.	Homocysteine	23-26	NLR family, pyrin domain containing 3	Mus musculus	146-151
31266025-5	2019	Rac1 activator, uridine triphosphate (UTP), mimicked L-Hcy-induced NLRP3 inflammasome activation, while Rac1 inhibitor NSC23766 blocked it.	Homocysteine	53-58	NLR family, pyrin domain containing 3	Mus musculus	67-72
31266025-4	2019	In cultured podocytes, we found that L-Hcy (the active Hcy form) stimulated the NLRP3 inflammasome formation, as shown by increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1, which was accompanied by increased interleukin-1beta production and caspase-1 activity, indicating NLRP3 inflammasome activation.	Homocysteine	37-42	NLR family, pyrin domain containing 3	Mus musculus	80-85
31266025-4	2019	In cultured podocytes, we found that L-Hcy (the active Hcy form) stimulated the NLRP3 inflammasome formation, as shown by increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1, which was accompanied by increased interleukin-1beta production and caspase-1 activity, indicating NLRP3 inflammasome activation.	Homocysteine	37-42	NLR family, pyrin domain containing 3	Mus musculus	150-155
31266025-8	2019	In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice.	Folic Acid	58-64	NLR family, pyrin domain containing 3	Mus musculus	95-100
31266025-4	2019	In cultured podocytes, we found that L-Hcy (the active Hcy form) stimulated the NLRP3 inflammasome formation, as shown by increased colocalization of NLRP3 with apoptosis-associated speck-like protein (ASC) or caspase-1, which was accompanied by increased interleukin-1beta production and caspase-1 activity, indicating NLRP3 inflammasome activation.	Homocysteine	37-42	NLR family, pyrin domain containing 3	Mus musculus	150-155
31266025-8	2019	In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice.	Folic Acid	58-64	NLR family, pyrin domain containing 3	Mus musculus	240-245
31266025-5	2019	Rac1 activator, uridine triphosphate (UTP), mimicked L-Hcy-induced NLRP3 inflammasome activation, while Rac1 inhibitor NSC23766 blocked it.	Uridine Triphosphate	16-36	NLR family, pyrin domain containing 3	Mus musculus	67-72
31266025-8	2019	In animal studies, hyperhomocysteinemia (hHcy) induced by folate-free diet was shown to induce NLRP3 inflammasome formation and activation in glomeruli, which was also mimicked by UTP and inhibited by NSC23766 to a comparable level seen in Nlrp3 gene knockout mice.	Uridine Triphosphate	180-183	NLR family, pyrin domain containing 3	Mus musculus	95-100
31266025-5	2019	Rac1 activator, uridine triphosphate (UTP), mimicked L-Hcy-induced NLRP3 inflammasome activation, while Rac1 inhibitor NSC23766 blocked it.	Uridine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	67-72
30496979-10	2019	Taken together, the current results demonstrated that palmatine protected mice against DSS-induced colitis by facilitating PINK1/Parkin-driven mitophagy and thus inactivating NLRP3 inflammasomes in macrophage.	palmatine	54-63	NLR family, pyrin domain containing 3	Mus musculus	175-180
30825154-7	2019	Low doses of LPS in combination with the specific hepatotoxic agent D-galactosamine (D-GalN) promote liver injury in mice and induce the production of inflammatory cytokines associated with increased NLRP3 protein and caspase 1 activity, thus recapitulating the clinical picture of FH in humans.	Galactosamine	68-83	NLR family, pyrin domain containing 3	Mus musculus	200-205
30496979-0	2019	Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.	palmatine	0-9	NLR family, pyrin domain containing 3	Mus musculus	99-104
30496979-0	2019	Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.	Dextran Sulfate	21-43	NLR family, pyrin domain containing 3	Mus musculus	99-104
30496979-0	2019	Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation.	Dextran Sulfate	45-48	NLR family, pyrin domain containing 3	Mus musculus	99-104
30496979-6	2019	Moreover, palmatine suppressed NLRP3 inflammasomes activation, but enhanced the expression of the mitophagy-related proteins involving LC3, PINK1 and Parkin in colonic tissue of DSS mice.	palmatine	10-19	NLR family, pyrin domain containing 3	Mus musculus	31-36
30439507-0	2019	Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages.	Reactive Oxygen Species	113-136	NLR family, pyrin domain containing 3	Mus musculus	58-63
30439507-4	2019	The present study aimed to investigate whether Omp34 elicited NLRP3 inflammasome activation through the mitochondria-derived reactive oxygen species (ROS).	Reactive Oxygen Species	125-148	NLR family, pyrin domain containing 3	Mus musculus	62-67
30439507-4	2019	The present study aimed to investigate whether Omp34 elicited NLRP3 inflammasome activation through the mitochondria-derived reactive oxygen species (ROS).	Reactive Oxygen Species	150-153	NLR family, pyrin domain containing 3	Mus musculus	62-67
30439507-7	2019	Additionally, Omp34 stimulated RAW264.7 mitochondria to generate ROS, while the ROS scavenger Mito-TEMPO inhibited the Omp34-triggered expression of NLRP3 inflammasome-associated proteins and IL-1beta synthesis.	Reactive Oxygen Species	80-83	NLR family, pyrin domain containing 3	Mus musculus	149-154
30439507-8	2019	The above findings indicate that mitochondria-derived ROS play an important role in the process of NLRP3 inflammasome activation.	Reactive Oxygen Species	54-57	NLR family, pyrin domain containing 3	Mus musculus	99-104
30439507-9	2019	In summary, our study demonstrates that the A. baumannii pathogen pattern recognition receptor Omp34 activates NLRP3 inflammasome via mitochondria-derived ROS in RAW264.7 cells.	Reactive Oxygen Species	155-158	NLR family, pyrin domain containing 3	Mus musculus	111-116
30439507-10	2019	Accordingly, down-regulating the mitochondria-derived ROS prevents the severe infection consequences caused by A. baumannii-induced NLRP3 inflammasome hyper-activation.	Reactive Oxygen Species	54-57	NLR family, pyrin domain containing 3	Mus musculus	132-137
30596806-11	2018	DCAC treatment resulted in significantly increased early and late-stage apoptosis, accompanied with inflammasome activation (NLRP3 increases).	2,2-dichloroacetyl chloride	0-4	NLR family, pyrin domain containing 3	Mus musculus	125-130
30544130-0	2018	Peroxisome Proliferator Activated Receptor gamma (PPARgamma) Agonist Rosiglitazone Ameliorate Airway Inflammation by Inhibiting Toll-Like Receptor 2 (TLR2)/Nod-Like Receptor with Pyrin Domain Containing 3 (NLRP3) Inflammatory Corpuscle Activation in Asthmatic Mice.	Rosiglitazone	69-82	NLR family, pyrin domain containing 3	Mus musculus	206-211
30098377-5	2018	NLRP3 knockout (KO) improved renal function, attenuated glomerular hypertrophy, glomerulosclerosis, mesangial expansion, interstitial fibrosis, inflammation and expression of TGF-beta1 and connective tissue growth factor (CTGF), as well as the activation of Smad3 in kidneys of STZ-induced diabetic mice.	Streptozocin	278-281	NLR family, pyrin domain containing 3	Mus musculus	0-5
30098377-6	2018	In addition, NLRP3 KO inhibited expression of thioredoxin-interacting protein (TXNIP) and NADPH oxidase 4 (Nox4) and superoxide production in diabetic kidneys.	Superoxides	117-127	NLR family, pyrin domain containing 3	Mus musculus	13-18
30098377-7	2018	The diabetes-induced increase in urinary level of 8-hydroxydeoxyguanosine (8-OHdG) was attenuated in NLRP3 KO mice.	8-ohdg	50-73	NLR family, pyrin domain containing 3	Mus musculus	101-106
30098377-7	2018	The diabetes-induced increase in urinary level of 8-hydroxydeoxyguanosine (8-OHdG) was attenuated in NLRP3 KO mice.	8-ohdg	75-81	NLR family, pyrin domain containing 3	Mus musculus	101-106
30098377-8	2018	In vitro experiments, using HK-2 cells, revealed that high glucose (HG)-mediated expression of TXNIP and Nox4 was inhibited by transfection with NLRP3 shRNA plasmid or antioxidant tempol treatment.	Glucose	59-66	NLR family, pyrin domain containing 3	Mus musculus	145-150
30098377-9	2018	Silencing of the NLRP3 resulted in reduced generation of reactive oxygen species (ROS) in HK-2 cells under HG conditions.	Reactive Oxygen Species	57-80	NLR family, pyrin domain containing 3	Mus musculus	17-22
30098377-9	2018	Silencing of the NLRP3 resulted in reduced generation of reactive oxygen species (ROS) in HK-2 cells under HG conditions.	Reactive Oxygen Species	82-85	NLR family, pyrin domain containing 3	Mus musculus	17-22
30472831-8	2018	Moreover, DSS induced the activation of mitogen-activated protein kinase (MAPK) and (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was inhibited by naringin.	Dextran Sulfate	10-13	NLR family, pyrin domain containing 3	Mus musculus	138-143
30662666-0	2018	Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kappaB and NLRP3 inflammasome.	muscone	0-7	NLR family, pyrin domain containing 3	Mus musculus	170-175
30662666-10	2018	To sum up, our study found that muscone alleviated cardiac macrophage-mediated chronic inflammation by inhibiting NF-kappaB and NLRP3 inflammasome activation, thereby improving cardiac function in MI mice.	muscone	32-39	NLR family, pyrin domain containing 3	Mus musculus	128-133
30379164-0	2018	Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-kappaB pathway.	methyl chlorogenate	0-29	NLR family, pyrin domain containing 3	Mus musculus	95-100
30544130-9	2018	CONCLUSIONS PPARgamma rosiglitazone ameliorates airway inflammation by inhibiting NF-kappaB expression in asthmatic mice, and further inhibits the activation of TLR2/NLRP3 inflammatory corpuscles.	Rosiglitazone	22-35	NLR family, pyrin domain containing 3	Mus musculus	166-171
30188752-7	2018	Thus, our research shows that GDF11 alleviates DSS-induced colitis by inhibiting NLRP3 inflammasome activation, providing some basis for its potential use in the treatment of UC.	dss	47-50	NLR family, pyrin domain containing 3	Mus musculus	81-86
30544722-0	2018	Gastrodin Alleviates Cognitive Dysfunction and Depressive-Like Behaviors by Inhibiting ER Stress and NLRP3 Inflammasome Activation in db/db Mice.	gastrodin	0-9	NLR family, pyrin domain containing 3	Mus musculus	101-106
30564782-7	2018	Self-cleavage at the D285 site is required to generate the fully active caspase-11 protease (proposed here to be p32/p10) that mediates gasdermin D cleavage, macrophage death, and NLRP3-dependent IL-1beta production.	d285	21-25	NLR family, pyrin domain containing 3	Mus musculus	180-185
30188752-6	2018	Furthermore, we found that GDF11 inhibited NLRP3 inflammasome activation by downregulating the Toll-like receptor 4/NF-kappaB p65 pathway and reactive oxygen species production via the typical Smad2/3 pathway.	Reactive Oxygen Species	142-165	NLR family, pyrin domain containing 3	Mus musculus	43-48
30387829-0	2018	Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells.	nobiletin	0-9	NLR family, pyrin domain containing 3	Mus musculus	43-48
29869390-0	2018	Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice.	dihydromyricetin	0-16	NLR family, pyrin domain containing 3	Mus musculus	85-90
30388519-0	2018	Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.	piperine	0-8	NLR family, pyrin domain containing 3	Mus musculus	78-83
30388519-3	2018	Here we assessed the therapeutic potential of piperine, a bioactive compound known to target NLRP3 inflammasome, on LN development both in vivo and in vitro.	piperine	46-54	NLR family, pyrin domain containing 3	Mus musculus	93-98
30388519-5	2018	Upon treatment with increasing doses of piperine, we assessed renal lesions, measured serum levels of pro-inflammatory cytokines, and examined expressions of key components of NLRP3 inflammasome in kidney.	piperine	40-48	NLR family, pyrin domain containing 3	Mus musculus	176-181
30388519-8	2018	RESULTS: In pristane-injected mice, piperine significantly ameliorated LN development in a dose-dependent manner, which was associated with the inhibition of NLRP3 inflammasome and the reduction of serum IL-1beta, but not of IL-18 level.	piperine	36-44	NLR family, pyrin domain containing 3	Mus musculus	158-163
30388519-9	2018	In HK-2 cells, piperine potently inhibited pyroptosis and the activation of NLRP3 inflammasome in response to LPS + ATP.	piperine	15-23	NLR family, pyrin domain containing 3	Mus musculus	76-81
30388519-9	2018	In HK-2 cells, piperine potently inhibited pyroptosis and the activation of NLRP3 inflammasome in response to LPS + ATP.	Adenosine Triphosphate	116-119	NLR family, pyrin domain containing 3	Mus musculus	76-81
30388519-10	2018	The effects of piperine were mediated by blocking AMPK activation, and the AMPK agonist metformin bypassed the activities of piperine, and resumed pyroptosis as well as the activation on NLRP3 inflammasome.	Metformin	88-97	NLR family, pyrin domain containing 3	Mus musculus	187-192
30388519-11	2018	CONCLUSIONS: By targeting AMPK, piperine significantly suppressed the activation of NLRP3 inflammasome, inhibited the release of pro-inflammatory cytokines, blocked the pyroptosis of tubular epithelial cells, and thus suppressed the development of LN.	piperine	32-40	NLR family, pyrin domain containing 3	Mus musculus	84-89
30422890-1	2018	BACKGROUND: A diet rich in saturated fat and sugars (Western diet, WD) induces myocardial expression of the NLRP3 inflammasome and dysfunction in mice.	saturated fat	27-40	NLR family, pyrin domain containing 3	Mus musculus	108-113
30422890-1	2018	BACKGROUND: A diet rich in saturated fat and sugars (Western diet, WD) induces myocardial expression of the NLRP3 inflammasome and dysfunction in mice.	Sugars	45-51	NLR family, pyrin domain containing 3	Mus musculus	108-113
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	55-60
30396035-0	2018	Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1beta production.	Dextran Sulfate	20-23	NLR family, pyrin domain containing 3	Mus musculus	55-60
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Curcumin	74-82	NLR family, pyrin domain containing 3	Mus musculus	150-155
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Dextran Sulfate	86-108	NLR family, pyrin domain containing 3	Mus musculus	150-155
30396035-3	2018	OBJECTIVE: The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1beta production.	Dextran Sulfate	110-113	NLR family, pyrin domain containing 3	Mus musculus	150-155
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	NLR family, pyrin domain containing 3	Mus musculus	56-61
30273598-2	2018	We first demonstrated that 7-ketocholesterol stimulated Nlrp3 inflammasome formation and activation as shown by increased colocalization of inflammasome components [Nlrp3 versus apoptosis associated speck-like protein (Asc) or caspase-1] and enhanced cleavage of caspase-1 into active caspase-1 to generate IL-1beta in coronary artery smooth muscle cells.	7-ketocholesterol	27-44	NLR family, pyrin domain containing 3	Mus musculus	165-170
30053645-11	2018	ATP levels reduced from day 7 to day 28 in NLRP3-/- recipients, but were extremely high in C57BL/6 recipients from day 14 to day 28 (P &lt; .01).	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	43-48
30053645-12	2018	The decreased levels of P2X7R were connected to less ATP in NLRP3-/- recipients at day 21 and day 28.	Adenosine Triphosphate	53-56	NLR family, pyrin domain containing 3	Mus musculus	60-65
30133699-3	2018	Here we analyzed the impact of different inflammasome components, including absent in melanoma 2 (AIM2) and NOD-like receptor family pyrin domain containing 3 (NLRP3), in the development of diethylnitrosamine (DEN)-induced HCC in mice.	Diethylnitrosamine	190-208	NLR family, pyrin domain containing 3	Mus musculus	160-165
30133699-3	2018	Here we analyzed the impact of different inflammasome components, including absent in melanoma 2 (AIM2) and NOD-like receptor family pyrin domain containing 3 (NLRP3), in the development of diethylnitrosamine (DEN)-induced HCC in mice.	Diethylnitrosamine	210-213	NLR family, pyrin domain containing 3	Mus musculus	160-165
29953588-6	2018	Compared with wild-type mice, NLRP3 knockout mice dramatically protected them from kidney injury, as indicated by the restoration of creatinine levels, lessened histopathological alterations, and the suppression of macrophages infiltration stained with F4/80.	Creatinine	133-143	NLR family, pyrin domain containing 3	Mus musculus	30-35
29953588-7	2018	NLRP3 deficiency notably reversed CIH-induced oxidative stress (malondialdehyde and superoxide dismutase), concomitantly with the abrogated apoptosis-related proteins and proinflammatory signaling pathway.	cih	34-37	NLR family, pyrin domain containing 3	Mus musculus	0-5
29953588-7	2018	NLRP3 deficiency notably reversed CIH-induced oxidative stress (malondialdehyde and superoxide dismutase), concomitantly with the abrogated apoptosis-related proteins and proinflammatory signaling pathway.	Malondialdehyde	64-79	NLR family, pyrin domain containing 3	Mus musculus	0-5
29953588-8	2018	Consistently, NLRP3-deficient tubular cells remarkably inhibited reactive oxygen species generation and NLRP3 inflammasome activation.	Reactive Oxygen Species	65-88	NLR family, pyrin domain containing 3	Mus musculus	14-19
29953588-11	2018	Inhibition of miR-155 suppressed the CIH-induced NLRP3 inflammasome activation in renal tubular cells, whereas overexpression of miR-155 promoted oxidation and enhanced NLRP3 pathway.	cih	37-40	NLR family, pyrin domain containing 3	Mus musculus	49-54
30387829-0	2018	Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells.	Palmitic Acid	21-34	NLR family, pyrin domain containing 3	Mus musculus	43-48
30396035-4	2018	METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed.	Curcumin	50-58	NLR family, pyrin domain containing 3	Mus musculus	83-88
30396035-4	2018	METHODS: LPS-primed macrophages were treated with curcumin prior to DSS triggering NLRP3 inflammasome activation, IL-1beta secretion and ASC oligomerization were observed.	Dextran Sulfate	68-71	NLR family, pyrin domain containing 3	Mus musculus	83-88
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Curcumin	69-77	NLR family, pyrin domain containing 3	Mus musculus	9-14
30396035-9	2018	RESULTS: NLRP3 inflammasome activation was dramatically inhibited by curcumin in DSS-stimulated macrophages, as evidenced by decreased IL-1beta secretion, less caspase-1 activation and ASC specks.	Dextran Sulfate	81-84	NLR family, pyrin domain containing 3	Mus musculus	9-14
30387829-1	2018	The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been reported to contribute to palmitic acid (PA)-induced lipotoxicity.	Palmitic Acid	111-124	NLR family, pyrin domain containing 3	Mus musculus	56-61
30396035-10	2018	Mechanistically, curcumin prevented DSS-induced K+ efflux, intracellular ROS formation and cathepsin B release, three major cellular events mediating NLRP3 inflammasome activation.	Curcumin	17-25	NLR family, pyrin domain containing 3	Mus musculus	150-155
30396035-10	2018	Mechanistically, curcumin prevented DSS-induced K+ efflux, intracellular ROS formation and cathepsin B release, three major cellular events mediating NLRP3 inflammasome activation.	Dextran Sulfate	36-39	NLR family, pyrin domain containing 3	Mus musculus	150-155
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Curcumin	136-144	NLR family, pyrin domain containing 3	Mus musculus	25-30
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Curcumin	136-144	NLR family, pyrin domain containing 3	Mus musculus	77-82
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Dextran Sulfate	148-151	NLR family, pyrin domain containing 3	Mus musculus	25-30
30387829-1	2018	The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been reported to contribute to palmitic acid (PA)-induced lipotoxicity.	Palmitic Acid	126-128	NLR family, pyrin domain containing 3	Mus musculus	56-61
30387829-7	2018	The results demonstrated that PA effectively activated NLRP3 inflammasome and increased the expression and secretion of interleukin (IL)-1beta and IL-18.	Palmitic Acid	30-32	NLR family, pyrin domain containing 3	Mus musculus	55-60
30396035-13	2018	Furthermore, blockage of NLRP3 inflammasome activation in vivo with specific NLRP3 inhibitor abrogated the further inhibitory effect of curcumin on DSS-induced colitis.	Dextran Sulfate	148-151	NLR family, pyrin domain containing 3	Mus musculus	77-82
30387829-8	2018	Notably, the PA-induced inflammasome activation was reversed by Nob, as indicated by the decreased expression levels of NLRP3, Caspase-1, IL-1beta and IL-18.	Palmitic Acid	13-15	NLR family, pyrin domain containing 3	Mus musculus	120-125
30396035-14	2018	CONCLUSION: Curcumin could strongly suppress DSS-induced NLRP3 inflammsome activation and alleviate DSS-induced colitis in mice, thus it may be a promising candidate drug in clinical application for IBD therapy.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	57-62
30396035-14	2018	CONCLUSION: Curcumin could strongly suppress DSS-induced NLRP3 inflammsome activation and alleviate DSS-induced colitis in mice, thus it may be a promising candidate drug in clinical application for IBD therapy.	Dextran Sulfate	45-48	NLR family, pyrin domain containing 3	Mus musculus	57-62
30387829-10	2018	Overall, the results of the present study indicated that Nob alleviated PA-induced lipotoxicity in AML-12 cells via the suppression of NLRP3 inflammasome activation in a SIRT1-dependent manner.	Palmitic Acid	72-74	NLR family, pyrin domain containing 3	Mus musculus	135-140
30548229-8	2018	LPS increased gastrocnemius mRNA expression of TNF-alpha and IL-1beta, and protein levels of NLRP3, all of which were attenuated by imoxin.	imoxin	132-138	NLR family, pyrin domain containing 3	Mus musculus	93-98
30662603-0	2018	MnTBAP treatment ameliorates aldosterone-induced renal injury by regulating mitochondrial dysfunction and NLRP3 inflammasome signalling.	Aldosterone	29-40	NLR family, pyrin domain containing 3	Mus musculus	106-111
30333233-6	2018	MCC950, a selective small-molecule inhibitor of canonical and noncanonical NLRP3 activation, reduced RXR expression, leading to decreased pAEC apoptosis that was reversed by the RXR agonist adapalene.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	75-80
30333233-9	2018	Critically, the HO-1 products carbon monoxide and bilirubin suppressed the NLRP3-RXR axis in pAECs.	Carbon Monoxide	30-45	NLR family, pyrin domain containing 3	Mus musculus	75-80
30333233-9	2018	Critically, the HO-1 products carbon monoxide and bilirubin suppressed the NLRP3-RXR axis in pAECs.	Bilirubin	50-59	NLR family, pyrin domain containing 3	Mus musculus	75-80
30524241-0	2018	Inhibiting the NLRP3 Inflammasome With MCC950 Ameliorates Isoflurane-Induced Pyroptosis and Cognitive Impairment in Aged Mice.	Isoflurane	58-68	NLR family, pyrin domain containing 3	Mus musculus	15-20
30524241-3	2018	This study explores the protective effects of the NLRP3 inflammasome inhibitor MCC950 on pyroptosis and cognitive impairment in aged mice exposed to isoflurane.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	79-85	NLR family, pyrin domain containing 3	Mus musculus	50-55
30524241-3	2018	This study explores the protective effects of the NLRP3 inflammasome inhibitor MCC950 on pyroptosis and cognitive impairment in aged mice exposed to isoflurane.	Isoflurane	149-159	NLR family, pyrin domain containing 3	Mus musculus	50-55
30524241-8	2018	We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice.	Isoflurane	14-24	NLR family, pyrin domain containing 3	Mus musculus	64-69
30524241-8	2018	We found that isoflurane GA caused upregulations of hippocampal NLRP3, cleaved caspase-1, interleukin-1beta (IL-1beta), and IL-18 and the activation of pyroptosis, which is NLRP3 inflammasome-dependent; this consequently gave rise to neuronal damage and cognitive impairment in aged mice.	Isoflurane	14-24	NLR family, pyrin domain containing 3	Mus musculus	173-178
30524241-9	2018	Interestingly, pretreatment with NLRP3 inflammasome inhibitor MCC950 not only provided a neuroprotective effect against the inflammasome activation but also ameliorated pyroptosis and cognitive impairment in aged mice exposed to isoflurane.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	62-68	NLR family, pyrin domain containing 3	Mus musculus	33-38
30524241-9	2018	Interestingly, pretreatment with NLRP3 inflammasome inhibitor MCC950 not only provided a neuroprotective effect against the inflammasome activation but also ameliorated pyroptosis and cognitive impairment in aged mice exposed to isoflurane.	Isoflurane	229-239	NLR family, pyrin domain containing 3	Mus musculus	33-38
30524241-10	2018	Our data demonstrate that pyroptosis is involved in NLRP3 inflammasome-mediated isoflurane-induced cognitive impairment in aged mice and suggest that inhibiting the NLRP3 inflammasome with MCC950 may have clinically therapeutic benefits for elderly patients undertaking GA.	Isoflurane	80-90	NLR family, pyrin domain containing 3	Mus musculus	52-57
30097755-3	2018	Previously, we and others elucidated porcine nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family Pyrin domain containing 3 (NLRP3) inflammasome activation.	porcine nucleotide	37-55	NLR family, pyrin domain containing 3	Mus musculus	147-152
30662603-7	2018	In addition, MnTBAP treatment of aldosterone-infused mice significantly improved mitochondrial morphology and function, suppressed the activation of NLRP3 inflammasome, reduced renal tubular cell apoptosis, decreased phenotypic alterations, and ameliorated renal apoptosis.	Aldosterone	33-44	NLR family, pyrin domain containing 3	Mus musculus	149-154
30662603-8	2018	We conclude that MnTBAP treatment ameliorates aldosterone-induced renal injury through regulating MtD and NLRP3 inflammsome signalling axis.	Aldosterone	46-57	NLR family, pyrin domain containing 3	Mus musculus	106-111
30424795-14	2018	HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1beta.	Lactic Acid	21-28	NLR family, pyrin domain containing 3	Mus musculus	147-152
30092543-2	2018	Although NLRP3 inflammasome activation is essential for development of many chronic diseases, the relationship between PM2.5-induced toxicological effect and NLRP3 inflammasome activation is rarely investigated.	[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE	119-122	NLR family, pyrin domain containing 3	Mus musculus	158-163
30092543-5	2018	PM2.5 could be internalized into cells through multiple endocytosis processes, such as phagocytosis and pinocytosis (macropinocytosis, clathrin- and caveolin-mediated endocytosis), and activate NLRP3 inflammasome through cathepsin B release, ROS production, and potassium efflux.	ros	242-245	NLR family, pyrin domain containing 3	Mus musculus	194-199
30092543-5	2018	PM2.5 could be internalized into cells through multiple endocytosis processes, such as phagocytosis and pinocytosis (macropinocytosis, clathrin- and caveolin-mediated endocytosis), and activate NLRP3 inflammasome through cathepsin B release, ROS production, and potassium efflux.	Potassium	262-271	NLR family, pyrin domain containing 3	Mus musculus	194-199
29802206-9	2018	CM-KI mice developed spontaneous premature atrial contractions and inducible AF, which was attenuated by a specific NLRP3 inflammasome inhibitor, MCC950.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	146-152	NLR family, pyrin domain containing 3	Mus musculus	116-121
30339173-6	2018	Importantly, DCA induced the activation of the NLRP3 inflammasome, increased the production of inflammatory cytokines, and led to intestinal low grade inflammation.	Deoxycholic Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	47-52
30424795-14	2018	HCAR1 stimulation by lactate or ketones from the ketogenic diet reduced inflammasome formation, as shown by reduced mRNA and protein expression of NLRP3 and IL-1beta.	Ketones	32-39	NLR family, pyrin domain containing 3	Mus musculus	147-152
30459553-8	2018	The neuroprotective and anti-inflammatory effects of 17-AGG were reversed by recombinant HSP90 (rHSP90); this detrimental effect of HSP90 was inhibited by the specific P2X7 receptor (P2X7R) inhibitor A438079, indicating that SAH-induced inflammation and inhibition of neurogenesis were likely mediated by HSP90 and the P2X7R/NLRP3 inflammasome pathway.	17-agg	53-59	NLR family, pyrin domain containing 3	Mus musculus	325-330
30459553-0	2018	Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.	tanespimycin	39-45	NLR family, pyrin domain containing 3	Mus musculus	85-90
30483252-8	2018	The deletion of NLRP3 or MAVS in renal tubular cells attenuated mitochondrial reactive oxygen species (ROS) production and depolarization of the mitochondrial membrane potentials under hypoxia.	Reactive Oxygen Species	78-101	NLR family, pyrin domain containing 3	Mus musculus	16-21
30483252-8	2018	The deletion of NLRP3 or MAVS in renal tubular cells attenuated mitochondrial reactive oxygen species (ROS) production and depolarization of the mitochondrial membrane potentials under hypoxia.	Reactive Oxygen Species	103-106	NLR family, pyrin domain containing 3	Mus musculus	16-21
30483252-9	2018	In response to UUO, NLRP3 KO mice showed less fibrosis, apoptosis, and ROS injury than wild type (WT) mice.	Reactive Oxygen Species	71-74	NLR family, pyrin domain containing 3	Mus musculus	20-25
30483252-11	2018	Our results indicate that inflammasome-independent NLRP3 in renal tubular cells plays important role in mitochondrial ROS production and injury by binding to MAVS after hypoxic injury.	Reactive Oxygen Species	118-121	NLR family, pyrin domain containing 3	Mus musculus	51-56
30459553-6	2018	However, intraperitoneal administration of the specific HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) reduced the levels of HSP90, NLRP3, ASC, caspase-1 and IL-1beta, while increasing the levels of brain-derived neurotrophic factor and doublecortin (DCX), as well as the number of BrdU-positive cells in SAH mice.	tanespimycin	72-110	NLR family, pyrin domain containing 3	Mus musculus	149-154
30257355-0	2018	Knockdown of TLR4 attenuates high glucose-induced podocyte injury via the NALP3/ASC/Caspase-1 signaling pathway.	Glucose	34-41	NLR family, pyrin domain containing 3	Mus musculus	74-79
30459553-6	2018	However, intraperitoneal administration of the specific HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) reduced the levels of HSP90, NLRP3, ASC, caspase-1 and IL-1beta, while increasing the levels of brain-derived neurotrophic factor and doublecortin (DCX), as well as the number of BrdU-positive cells in SAH mice.	tanespimycin	112-118	NLR family, pyrin domain containing 3	Mus musculus	149-154
30016155-5	2018	Furthermore, NLRP3 and ASC-deficient mice were protected against oxidative stress-induced diabetes caused by repetitive low-dose alloxan administration, and this was associated with reduced beta-cell death and reduced macrophage infiltration.	Alloxan	129-136	NLR family, pyrin domain containing 3	Mus musculus	13-18
30354239-3	2018	Recently, it has been reported that cholesterol crystals activate NLRP3 (NACHT, LRR [leucine-rich repeats], and PYD [pyrin domain] domain-containing protein 3) inflammasomes, thereby contributing to the development of atherosclerosis.	Cholesterol	36-47	NLR family, pyrin domain containing 3	Mus musculus	66-71
30257355-4	2018	In this study, we found that high glucose (HG) activated nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NALP3) inflammasome, as shown by elevated NALP3, apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) and cleaved caspase-1 protein levels, and increased caspase-1 activity in mouse podocytes in vitro.	Glucose	34-41	NLR family, pyrin domain containing 3	Mus musculus	151-156
30257355-4	2018	In this study, we found that high glucose (HG) activated nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NALP3) inflammasome, as shown by elevated NALP3, apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) and cleaved caspase-1 protein levels, and increased caspase-1 activity in mouse podocytes in vitro.	Glucose	34-41	NLR family, pyrin domain containing 3	Mus musculus	193-198
30031824-0	2018	Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-kappaB, and the induction of autophagy.	daphnetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	106-111
29786071-9	2018	We also found that Drd2 agonists suppressed the upregulation of caspase-1 and IL-1beta expression in primary cultured mouse astrocytes in response to the activation of NLRP3 inflammasome induced by lipopolysaccharide plus adenosine triphosphate.	Adenosine Triphosphate	222-244	NLR family, pyrin domain containing 3	Mus musculus	168-173
29981343-7	2018	REC grown in high glucose transfected with the miR15a mimic had decreased levels of Foxo1 and NLRP3.	Glucose	18-25	NLR family, pyrin domain containing 3	Mus musculus	94-99
30031824-0	2018	Daphnetin alleviates lipopolysaccharide/d-galactosamine-induced acute liver failure via the inhibition of NLRP3, MAPK and NF-kappaB, and the induction of autophagy.	Galactosamine	40-55	NLR family, pyrin domain containing 3	Mus musculus	106-111
30031824-5	2018	Moreover, Daph treatment effectively inhibited LPS/GalN-induced nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) signaling pathway activation, and significantly induced autophagy activation by enhancing the level of pro-autophagy proteins expression.	daphnetin	10-14	NLR family, pyrin domain containing 3	Mus musculus	121-126
30170255-0	2018	Melatonin inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in lipopolysaccharide-induced endometritis in mice.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	65-70
30031824-6	2018	Taken together, these findings suggested that Daph plays a pivotal role in liver protection by suppressing inflammatory responses which may be closely associated with the inhibition of NLRP3 inflammasome, MAPK and NF-kappaB activation, as well as the induction of autophagy.	daphnetin	46-50	NLR family, pyrin domain containing 3	Mus musculus	185-190
30170255-6	2018	Melatonin also inhibited LPS-induced thioredoxin-interacting protein (TXNIP)/NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-kappaB) activation, reactive oxygen species (ROS) production, and endoplasmic reticulum (ER) stress.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	130-135
30019185-9	2018	Palmitic acid was used to stimulate Kupffer cells (KCs), and protein expressions of CTSB, NLRP3, ASC (apoptosis-associated speck-like protein containing CARD), and caspase-1 in KCs were detected.	Palmitic Acid	0-13	NLR family, pyrin domain containing 3	Mus musculus	90-95
30170255-8	2018	In conclusion, our results demonstrated that melatonin inhibited ER stress-associated TXNIP/NLRP3 inflammasome activation with a regulation of adenosine monophosphate activated protein kinase (AMPK) in LPS-induced endometritis.	Melatonin	45-54	NLR family, pyrin domain containing 3	Mus musculus	92-97
30266768-2	2018	Neutrophils also have functional NLRP3 and NLRC4 inflammasomes that can process pro-IL-1beta to the bioactive 17-kDa form.	17-kda	110-116	NLR family, pyrin domain containing 3	Mus musculus	33-38
30102002-0	2018	Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury by targeting NLRP3 via miR-381.	Dexmedetomidine	0-15	NLR family, pyrin domain containing 3	Mus musculus	85-90
30102002-8	2018	Dex treatment significantly attenuated lung injury and inhibited the expression levels of the inflammation factors via reducing the level of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and autocleavage of caspase-1.	Dexmedetomidine	0-3	NLR family, pyrin domain containing 3	Mus musculus	141-189
30102002-8	2018	Dex treatment significantly attenuated lung injury and inhibited the expression levels of the inflammation factors via reducing the level of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and autocleavage of caspase-1.	Dexmedetomidine	0-3	NLR family, pyrin domain containing 3	Mus musculus	191-196
30102002-9	2018	Moreover, mmu-miR-381, which targets the mRNA of NLRP3, was upregulated after Dex treatment.	Dexmedetomidine	78-81	NLR family, pyrin domain containing 3	Mus musculus	49-54
30102002-10	2018	Dex attenuates LPS-induced acute lung injury via miR-381-targeted NLRP3.	Dexmedetomidine	0-3	NLR family, pyrin domain containing 3	Mus musculus	66-71
30019185-13	2018	In in vitro experiments, PA stimulation could increase the expressions of CTSB and NLRP3 inflammasome in KCs, and CTSB inhibition downregulated the expression of NLRP3 inflammasome in KCs, when challenged by PA.	Protactinium	25-27	NLR family, pyrin domain containing 3	Mus musculus	83-88
30019185-13	2018	In in vitro experiments, PA stimulation could increase the expressions of CTSB and NLRP3 inflammasome in KCs, and CTSB inhibition downregulated the expression of NLRP3 inflammasome in KCs, when challenged by PA.	Protactinium	208-210	NLR family, pyrin domain containing 3	Mus musculus	162-167
30152849-7	2018	However, blocking p38 MAPK signaling through the inhibitor SB203580 significantly suppressed the acute lung injury and excessive lung inflammation in vivo, consistent with the reduced expression of the NLRP3 inflammasome and IL-1beta and cleavage of caspase-1.	SB 203580	59-67	NLR family, pyrin domain containing 3	Mus musculus	202-207
30382081-3	2018	Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or ATP, as assessed using gene knockout and gene knockdown cells, dominant active/negative mutants, and pharmacological inhibition.	Nigericin	153-162	NLR family, pyrin domain containing 3	Mus musculus	93-98
30312877-0	2018	Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide.	Reactive Oxygen Species	54-57	NLR family, pyrin domain containing 3	Mus musculus	64-69
30312877-8	2018	Furthermore, ROS generation inhibitor (Apocynin; APO) significantly reduced Nlrp3 inflammasome formation and IL-1beta production in mPDLFs with P.g-LPS.	Reactive Oxygen Species	13-16	NLR family, pyrin domain containing 3	Mus musculus	76-81
30312877-10	2018	In conclusion, our results demonstrate that ROS/TXNIP/Nlrp3 Inflammasome pathway is a key initiating mechanism necessary for P.g-LPS-induced subsequent mPDLFs inflammatory response leading to chronic periodontitis.	Reactive Oxygen Species	44-47	NLR family, pyrin domain containing 3	Mus musculus	54-59
30591104-10	2018	Meanwhile, the levels of TC, FC, CE/TC, and the expression of NLRP3, ASC, caspase-1 in TMZ combined with CQ group were reduced obviously.	Chloroquine	105-107	NLR family, pyrin domain containing 3	Mus musculus	62-67
30591104-13	2018	Conclusion Trimetazidine promotes cholesterol efflux in foam cells via activating autophagy and increasing the formation of MET, as well as inhibiting NLRP3 inflammasome.	Trimetazidine	11-24	NLR family, pyrin domain containing 3	Mus musculus	151-156
30382081-3	2018	Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or ATP, as assessed using gene knockout and gene knockdown cells, dominant active/negative mutants, and pharmacological inhibition.	Adenosine Triphosphate	166-169	NLR family, pyrin domain containing 3	Mus musculus	93-98
30375483-0	2018	Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis.	Reactive Oxygen Species	53-56	NLR family, pyrin domain containing 3	Mus musculus	57-62
30429827-0	2018	Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.	Verapamil	0-9	NLR family, pyrin domain containing 3	Mus musculus	91-96
30429827-13	2018	The observed results demonstrate that verapamil ameliorates hepatic metaflammation by inhibiting TXNIP/NLRP3 pathways.	Verapamil	38-47	NLR family, pyrin domain containing 3	Mus musculus	103-108
30375483-10	2018	These data demonstrated that A. adenophora caused liver inflammatory injury and induced hepatocyte pyroptosis by activating NLRP3 inflammasome, which was triggered by elevating ROS production levels.	Reactive Oxygen Species	177-180	NLR family, pyrin domain containing 3	Mus musculus	124-129
29795356-0	2018	Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARgamma/NF-kappaB/NLRP3 inflammasome axis.	astragaloside A	0-16	NLR family, pyrin domain containing 3	Mus musculus	117-122
30360489-0	2018	The Small Molecule NLRP3 Inflammasome Inhibitor MCC950 Does Not Alter Wound Healing in Obese Mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	48-54	NLR family, pyrin domain containing 3	Mus musculus	19-24
30360489-4	2018	As the NLRP3 inflammasome has been implicated with various other inflammatory diseases, in this study, we used MCC950-a selective NLRP3 small molecule inhibitor-on murine models of both acute and chronic wounds.	mcc950-a	111-119	NLR family, pyrin domain containing 3	Mus musculus	7-12
30360489-4	2018	As the NLRP3 inflammasome has been implicated with various other inflammatory diseases, in this study, we used MCC950-a selective NLRP3 small molecule inhibitor-on murine models of both acute and chronic wounds.	mcc950-a	111-119	NLR family, pyrin domain containing 3	Mus musculus	130-135
30315247-6	2018	NLRP3-/- had increased circulating free fatty acids (FFA), fatty deposition and liver weight 1 hour post-burn.	Fatty Acids	40-51	NLR family, pyrin domain containing 3	Mus musculus	0-5
30185517-0	2018	Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice.	Curcumin	31-39	NLR family, pyrin domain containing 3	Mus musculus	66-71
30185517-2	2018	In this study, we screened a series of small compounds with anti-inflammatory activities and identified a novel NLRP3 inflammasome inhibitor, AI-44, a curcumin analogue that selectively inhibited signal 2 but not signal 1 of NLRP3 inflammasome activation.	ai-44	142-147	NLR family, pyrin domain containing 3	Mus musculus	112-117
30185517-2	2018	In this study, we screened a series of small compounds with anti-inflammatory activities and identified a novel NLRP3 inflammasome inhibitor, AI-44, a curcumin analogue that selectively inhibited signal 2 but not signal 1 of NLRP3 inflammasome activation.	ai-44	142-147	NLR family, pyrin domain containing 3	Mus musculus	225-230
30185517-2	2018	In this study, we screened a series of small compounds with anti-inflammatory activities and identified a novel NLRP3 inflammasome inhibitor, AI-44, a curcumin analogue that selectively inhibited signal 2 but not signal 1 of NLRP3 inflammasome activation.	Curcumin	151-159	NLR family, pyrin domain containing 3	Mus musculus	112-117
30333752-9	2018	Importantly, trans-Chalcone reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation and thereby the mRNA expression of the inflammasome components Nlrp3 (cryopyrin), Asc (apoptosis-associated speck-like protein containing a CARD), Pro-caspase-1 and Pro-IL-1beta.	Chalcone	13-27	NLR family, pyrin domain containing 3	Mus musculus	185-190
30333752-9	2018	Importantly, trans-Chalcone reduced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation and thereby the mRNA expression of the inflammasome components Nlrp3 (cryopyrin), Asc (apoptosis-associated speck-like protein containing a CARD), Pro-caspase-1 and Pro-IL-1beta.	Chalcone	13-27	NLR family, pyrin domain containing 3	Mus musculus	192-201
30103942-0	2018	Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release.	Fatty Acids	0-10	NLR family, pyrin domain containing 3	Mus musculus	21-26
30103942-10	2018	NLRP3 inflammasome expression was substantially increased, and mtDNA-NLRP3 inflammasome complexes formed upon PA stimulation.	Palmitic Acid	110-112	NLR family, pyrin domain containing 3	Mus musculus	69-74
30103942-11	2018	Our data suggest that mtDNA released from mitochondria during PA stimulation causes NLRP3 inflammasome activation, providing a missing link between NLRP3 inflammasome activation and NASH development, via binding of cytosolic mtDNA to the NLRP3 inflammasome.	Palmitic Acid	62-64	NLR family, pyrin domain containing 3	Mus musculus	84-89
30103942-11	2018	Our data suggest that mtDNA released from mitochondria during PA stimulation causes NLRP3 inflammasome activation, providing a missing link between NLRP3 inflammasome activation and NASH development, via binding of cytosolic mtDNA to the NLRP3 inflammasome.	Palmitic Acid	62-64	NLR family, pyrin domain containing 3	Mus musculus	148-153
30103942-11	2018	Our data suggest that mtDNA released from mitochondria during PA stimulation causes NLRP3 inflammasome activation, providing a missing link between NLRP3 inflammasome activation and NASH development, via binding of cytosolic mtDNA to the NLRP3 inflammasome.	Palmitic Acid	62-64	NLR family, pyrin domain containing 3	Mus musculus	148-153
30114748-0	2018	AlCl3 inhibits LPS-induced NLRP3 inflammasome activation and IL-1beta production through suppressing NF-kappaB signaling pathway in murine peritoneal macrophages.	Aluminum Chloride	0-5	NLR family, pyrin domain containing 3	Mus musculus	27-32
30114748-5	2018	Besides, AlCl3 exposure restrained the LPS-induced NLR pyrin domain containing 3 (NLRP3) inflammasome activation presented as NLRP3 expressions reduction, caspase-1 cleavage inhibition and interleukin 1 beta (IL-1beta) maturation lessened.	Aluminum Chloride	9-14	NLR family, pyrin domain containing 3	Mus musculus	82-87
30114748-5	2018	Besides, AlCl3 exposure restrained the LPS-induced NLR pyrin domain containing 3 (NLRP3) inflammasome activation presented as NLRP3 expressions reduction, caspase-1 cleavage inhibition and interleukin 1 beta (IL-1beta) maturation lessened.	Aluminum Chloride	9-14	NLR family, pyrin domain containing 3	Mus musculus	126-131
30114748-7	2018	The results suggested that AlCl3 inhibited the activation of NF-kappaB signaling pathway induced by LPS, which maybe one of the upstream signals involved in the inhibition of NLRP3 inflammasome activation by AlCl3.	Aluminum Chloride	27-32	NLR family, pyrin domain containing 3	Mus musculus	175-180
30114748-7	2018	The results suggested that AlCl3 inhibited the activation of NF-kappaB signaling pathway induced by LPS, which maybe one of the upstream signals involved in the inhibition of NLRP3 inflammasome activation by AlCl3.	Aluminum Chloride	208-213	NLR family, pyrin domain containing 3	Mus musculus	175-180
29852215-6	2018	Molecular biology analyses suggested that both TLR2/MyD88/NF-kappaB pathway and NLRP3 inflammasome participated in the CdTe QD-induced IL-1ss secretion.	cadmium telluride	119-123	NLR family, pyrin domain containing 3	Mus musculus	80-85
29804160-10	2018	The NLRP3 inflammasome activator monosodium urate partly abrogated the effect of melatonin on the expression of osteoblastogenic markers, including Runx2 and OCN.	Uric Acid	33-49	NLR family, pyrin domain containing 3	Mus musculus	4-9
29804160-10	2018	The NLRP3 inflammasome activator monosodium urate partly abrogated the effect of melatonin on the expression of osteoblastogenic markers, including Runx2 and OCN.	Melatonin	81-90	NLR family, pyrin domain containing 3	Mus musculus	4-9
29804160-11	2018	Additionally, the results showed that melatonin suppressed NLRP3 inflammasome activation by regulating Wnt/beta-catenin signaling, which was confirmed by the Wnt/beta-catenin inhibitor recombinant DKK1.	Melatonin	38-47	NLR family, pyrin domain containing 3	Mus musculus	59-64
29804160-12	2018	These results indicated that melatonin ameliorates estrogen deficiency-induced osteoporosis and impaired osteogenic differentiation potential by suppressing activation of the NLRP3 inflammasome via mediating the Wnt/beta-catenin pathway.	Melatonin	29-38	NLR family, pyrin domain containing 3	Mus musculus	175-180
30197023-0	2018	AMSC-derived exosomes alleviate lipopolysaccharide/d-galactosamine-induced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages.	Galactosamine	51-66	NLR family, pyrin domain containing 3	Mus musculus	133-138
29885354-8	2018	However, the addition of Klotho to the TCDD + LPS-cotreated cells significantly increased PDLIM2 and decreased p65 activation and NLRP3 (p &lt; 0.05).	Polychlorinated Dibenzodioxins	39-43	NLR family, pyrin domain containing 3	Mus musculus	130-135
29804160-0	2018	Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	114-119
30107367-0	2018	Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-kappaB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.	Ginsenosides	21-32	NLR family, pyrin domain containing 3	Mus musculus	98-103
30107367-11	2018	In conclusion, our study provided evidence that the protective effect of CK on diabetes-induced renal injury is associated with down-regulating the expression of NADHP oxidase, and inhibition of ROS-mediated activation of NLRP3 inflammasome and NF-kappaB/p38 signaling pathway, suggesting its therapeutic implication for renal inflammation.	ginsenoside M1	73-75	NLR family, pyrin domain containing 3	Mus musculus	222-227
30107367-11	2018	In conclusion, our study provided evidence that the protective effect of CK on diabetes-induced renal injury is associated with down-regulating the expression of NADHP oxidase, and inhibition of ROS-mediated activation of NLRP3 inflammasome and NF-kappaB/p38 signaling pathway, suggesting its therapeutic implication for renal inflammation.	ros	195-198	NLR family, pyrin domain containing 3	Mus musculus	222-227
29885354-7	2018	Compared with the LPS-treated cells, expression of Klotho and PDLIM2 was significantly decreased in TCDD + LPS-treated cells (p &lt; 0.05), while expression of p65 and NLRP3 were significantly increased in the cotreatment cells (p &lt; 0.05).	Polychlorinated Dibenzodioxins	100-104	NLR family, pyrin domain containing 3	Mus musculus	168-173
29852215-8	2018	The results, taken together, demonstrated that MPA-modified CdTe QDs exposure with a high concentration was capable of activating microglial cells and promoting IL-1ss secretion, which was highly correlated with the activations of both TLR2/MyD88/NF-kappaB pathway and ROS-induced NLRP3 inflammasome.	cadmium telluride	60-64	NLR family, pyrin domain containing 3	Mus musculus	281-286
30146255-0	2018	The selective Nlrp3 inflammasome inhibitor Mcc950 attenuates lung ischemia-reperfusion injury.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	43-49	NLR family, pyrin domain containing 3	Mus musculus	14-19
30237538-4	2018	In mouse livers, we show that arsenic trioxide (As2O3) induced NASH, increased autophagy and NLRP3 inflammasome activation, increased lipid accumulation, and resulted in dysregulation of lipid-related genes.	Arsenic Trioxide	30-46	NLR family, pyrin domain containing 3	Mus musculus	93-98
30237538-4	2018	In mouse livers, we show that arsenic trioxide (As2O3) induced NASH, increased autophagy and NLRP3 inflammasome activation, increased lipid accumulation, and resulted in dysregulation of lipid-related genes.	Arsenic Trioxide	48-53	NLR family, pyrin domain containing 3	Mus musculus	93-98
30363922-0	2018	Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation.	Sevoflurane	0-11	NLR family, pyrin domain containing 3	Mus musculus	42-47
30363922-9	2018	Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA-induced activity of NLRP3 in the lungs.	Sevoflurane	13-24	NLR family, pyrin domain containing 3	Mus musculus	91-96
30363922-9	2018	Furthermore, sevoflurane, similar to MCC950, clearly inhibited the OVA-induced activity of NLRP3 in the lungs.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	37-43	NLR family, pyrin domain containing 3	Mus musculus	91-96
30363922-11	2018	Conclusion: Taken together, our data showed that sevoflurane ameliorated allergic airway inflammation by inhibiting Th2 responses and NLRP3 expression.	Sevoflurane	49-60	NLR family, pyrin domain containing 3	Mus musculus	134-139
30146255-4	2018	The aim of our study was to test the efficacy of Mcc950 on lung IR injury and to investigate the role of reactive oxygen species (ROS) in Nlrp3 inflammasome activation using a murine lung IR model.	Reactive Oxygen Species	105-128	NLR family, pyrin domain containing 3	Mus musculus	138-143
30146255-4	2018	The aim of our study was to test the efficacy of Mcc950 on lung IR injury and to investigate the role of reactive oxygen species (ROS) in Nlrp3 inflammasome activation using a murine lung IR model.	Reactive Oxygen Species	130-133	NLR family, pyrin domain containing 3	Mus musculus	138-143
30146255-5	2018	The results of the current study confirmed that Nlrp3 was upregulated and activated during lung IR, and inhibiting oxidative stress by the ROS scavenger edaravone attenuated Nlrp3 inflammasome activation.	Edaravone	153-162	NLR family, pyrin domain containing 3	Mus musculus	174-179
30146255-8	2018	Therefore, we conclude that ROS-dependent activation of the Nlrp3 inflammasome contributed to lung IR injury.	Reactive Oxygen Species	28-31	NLR family, pyrin domain containing 3	Mus musculus	60-65
30189890-6	2018	Arhalofenate acid (100 muM) attenuated MSU crystal-induced IL-1beta production in BMDMs via inhibition of NLRP3 inflammasome activation.	arhalofenate acid	0-17	NLR family, pyrin domain containing 3	Mus musculus	106-111
30209319-0	2018	Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.	Mercury	0-7	NLR family, pyrin domain containing 3	Mus musculus	58-63
30209319-0	2018	Mercury and arsenic attenuate canonical and non-canonical NLRP3 inflammasome activation.	Arsenic	12-19	NLR family, pyrin domain containing 3	Mus musculus	58-63
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Cadmium	73-80	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Cadmium	82-84	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Mercury	87-94	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Mercury	96-98	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Arsenic	101-108	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Arsenic	110-112	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-4	2018	In this study, we elucidated the effects of four heavy metals, including cadmium (Cd), mercury (Hg), arsenic (As), and lead (Pb), on the activation of NLRP3, NLRC4, and AIM2 inflammasomes.	Lead	125-127	NLR family, pyrin domain containing 3	Mus musculus	151-156
30209319-5	2018	In our results, mercury and arsenic inhibited interleukin (IL)-1beta and IL-18 secretion resulting from canonical and non-canonical NLRP3 inflammasome activation in macrophages and attenuated elevation of serum IL-1beta in response to LPS treatment in mice.	Mercury	16-23	NLR family, pyrin domain containing 3	Mus musculus	132-137
30209319-5	2018	In our results, mercury and arsenic inhibited interleukin (IL)-1beta and IL-18 secretion resulting from canonical and non-canonical NLRP3 inflammasome activation in macrophages and attenuated elevation of serum IL-1beta in response to LPS treatment in mice.	Arsenic	28-35	NLR family, pyrin domain containing 3	Mus musculus	132-137
30254716-10	2018	Mitochondrial ROS (mitoROS), which was a recognized inducer for NLRP3 inflammasome, was attenuated by melatonin through the induction of mitophagy.	Reactive Oxygen Species	14-17	NLR family, pyrin domain containing 3	Mus musculus	64-69
29859191-6	2018	In conclusion, our data showed that INT-777 could protect pancreatic acinar cell against necrosis and reduce the severity of AP, which may be mediated by inhibiting ROS/NLRP3 inflammasome pathway.	Reactive Oxygen Species	165-168	NLR family, pyrin domain containing 3	Mus musculus	169-174
30254716-0	2018	Melatonin Ameliorates the Progression of Atherosclerosis via Mitophagy Activation and NLRP3 Inflammasome Inhibition.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	86-91
30254716-4	2018	Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages.	Melatonin	28-37	NLR family, pyrin domain containing 3	Mus musculus	59-64
30254716-10	2018	Mitochondrial ROS (mitoROS), which was a recognized inducer for NLRP3 inflammasome, was attenuated by melatonin through the induction of mitophagy.	Melatonin	102-111	NLR family, pyrin domain containing 3	Mus musculus	64-69
30254716-4	2018	Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages.	Reactive Oxygen Species	119-142	NLR family, pyrin domain containing 3	Mus musculus	59-64
30254716-4	2018	Herein, we demonstrate that melatonin suppressed prolonged NLRP3 inflammasome activation in atherosclerotic lesions by reactive oxygen species (ROS) scavenging via mitophagy in macrophages.	Reactive Oxygen Species	144-147	NLR family, pyrin domain containing 3	Mus musculus	59-64
30254716-11	2018	Both Sirt3-siRNA and autophagy inhibitor 3-MA partially abolished the beneficial effects of melatonin on mitoROS clearance and NLRP3 inflammasome activation, indicating the crucial role of Sirt3-mediated mitophagy.	3-methyladenine	41-45	NLR family, pyrin domain containing 3	Mus musculus	127-132
30254716-7	2018	Furthermore, melatonin decreased NLRP3 inflammasome activation and the consequent IL-1beta secretion within atherosclerotic lesions.	Melatonin	13-22	NLR family, pyrin domain containing 3	Mus musculus	33-38
30254716-13	2018	In conclusion, the current study demonstrated that melatonin prevented atherosclerotic progression, at least in part, via inducing mitophagy and attenuating NLRP3 inflammasome activation, which was mediated by the Sirt3/FOXO3a/Parkin signaling pathway.	Melatonin	51-60	NLR family, pyrin domain containing 3	Mus musculus	157-162
30254716-9	2018	In ox-LDL-treated macrophages, melatonin attenuated the NLRP3 inflammasome activation and the inflammatory factors secretion, while this protective effect was abolished by either Sirt3 silence or autophagy inhibitor 3-MA.	Melatonin	31-40	NLR family, pyrin domain containing 3	Mus musculus	56-61
30060081-0	2018	mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus.	Reactive Oxygen Species	49-72	NLR family, pyrin domain containing 3	Mus musculus	15-20
30060081-5	2018	The inhibition of mTOR by INK128, a novel mTORC1/2 inhibitor, suppressed LPS/ATP and LPS/nigericin-induced NLRP3 inflammasome activation in bone marrow-derived macrophages (BMDMs) in vitro.	INK128	26-32	NLR family, pyrin domain containing 3	Mus musculus	107-112
30060081-5	2018	The inhibition of mTOR by INK128, a novel mTORC1/2 inhibitor, suppressed LPS/ATP and LPS/nigericin-induced NLRP3 inflammasome activation in bone marrow-derived macrophages (BMDMs) in vitro.	Nigericin	89-98	NLR family, pyrin domain containing 3	Mus musculus	107-112
30060081-6	2018	INK128 decreased both the mRNA and protein levels of NLRP3 in an NF-kappaB-independent manner.	INK128	0-6	NLR family, pyrin domain containing 3	Mus musculus	53-58
30060081-7	2018	Moreover, we reported for the first time that the inhibition of mTOR suppressed mitochondrial reactive oxygen species (ROS) production in BMDMs stimulated by an NLRP3 agonist.	Reactive Oxygen Species	94-117	NLR family, pyrin domain containing 3	Mus musculus	161-166
30060081-7	2018	Moreover, we reported for the first time that the inhibition of mTOR suppressed mitochondrial reactive oxygen species (ROS) production in BMDMs stimulated by an NLRP3 agonist.	Reactive Oxygen Species	119-122	NLR family, pyrin domain containing 3	Mus musculus	161-166
30060081-8	2018	Furthermore, N-acetyl-L-cysteine, a ROS inhibitor, decreased NLRP3 expression, and rotenone, a robust ROS inducer, partially reversed the inhibitory effect of INK128 on NLRP3.	Acetylcysteine	13-32	NLR family, pyrin domain containing 3	Mus musculus	61-66
30060081-8	2018	Furthermore, N-acetyl-L-cysteine, a ROS inhibitor, decreased NLRP3 expression, and rotenone, a robust ROS inducer, partially reversed the inhibitory effect of INK128 on NLRP3.	Rotenone	83-91	NLR family, pyrin domain containing 3	Mus musculus	169-174
30060081-8	2018	Furthermore, N-acetyl-L-cysteine, a ROS inhibitor, decreased NLRP3 expression, and rotenone, a robust ROS inducer, partially reversed the inhibitory effect of INK128 on NLRP3.	INK128	159-165	NLR family, pyrin domain containing 3	Mus musculus	169-174
30060081-9	2018	These results demonstrated that mTOR regulated the activation of the NLRP3 inflammasome at least partially via ROS-induced NLRP3 expression.	Reactive Oxygen Species	111-114	NLR family, pyrin domain containing 3	Mus musculus	69-74
30060081-9	2018	These results demonstrated that mTOR regulated the activation of the NLRP3 inflammasome at least partially via ROS-induced NLRP3 expression.	Reactive Oxygen Species	111-114	NLR family, pyrin domain containing 3	Mus musculus	123-128
30060081-10	2018	Importantly, in vivo data demonstrated that INK128 treatment prominently attenuated lupus nephritis and suppressed NLRP3 inflammasome activation in B6.MRL-FASlpr/J lupus mice.	INK128	44-50	NLR family, pyrin domain containing 3	Mus musculus	115-120
29859240-0	2018	Hydrogen sulfide attenuates oxidative stress-induced NLRP3 inflammasome activation via S-sulfhydrating c-Jun at Cys269 in macrophages.	Hydrogen Sulfide	0-16	NLR family, pyrin domain containing 3	Mus musculus	53-58
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	cardamonin	0-10	NLR family, pyrin domain containing 3	Mus musculus	90-95
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	flavone	22-29	NLR family, pyrin domain containing 3	Mus musculus	90-95
30071202-5	2018	In vitro, cardamonin inhibited NLRP3 inflammasome activation in THP-1 and bone marrow-derived macrophages.	cardamonin	10-20	NLR family, pyrin domain containing 3	Mus musculus	31-36
30071202-7	2018	The AhR antagonist CH223191 obviously abolished NLRP3 inflammasome activation inhibited by cardamonin.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	NLR family, pyrin domain containing 3	Mus musculus	48-53
29859240-4	2018	We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages.	Hydrogen Peroxide	37-54	NLR family, pyrin domain containing 3	Mus musculus	70-75
29859240-4	2018	We reported here that H2S attenuated hydrogen peroxide (H2O2)-induced NLRP3 inflammasome activation, which led to caspase-1 activation and IL-1beta production in macrophages.	Hydrogen Peroxide	56-60	NLR family, pyrin domain containing 3	Mus musculus	70-75
29845284-0	2018	Linarin prevents LPS-induced acute lung injury by suppressing oxidative stress and inflammation via inhibition of TXNIP/NLRP3 and NF-kappaB pathways.	linarin	0-7	NLR family, pyrin domain containing 3	Mus musculus	120-125
29740969-1	2018	AIM: To analyze the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018 as the peripherally restricted cannabinoid 1 receptor (CB1R) antagonist.	aj5018	156-162	NLR family, pyrin domain containing 3	Mus musculus	77-82
30021379-8	2018	Further experiments indicated that NLRP3-ASC pathway was activated by reactive oxygen species (ROS), since ROS scavenger of N-acetyl-cysteine (NAC) prevented, which was further reduced by PepE addition.	Reactive Oxygen Species	70-93	NLR family, pyrin domain containing 3	Mus musculus	35-40
30021379-8	2018	Further experiments indicated that NLRP3-ASC pathway was activated by reactive oxygen species (ROS), since ROS scavenger of N-acetyl-cysteine (NAC) prevented, which was further reduced by PepE addition.	Reactive Oxygen Species	95-98	NLR family, pyrin domain containing 3	Mus musculus	35-40
30021379-8	2018	Further experiments indicated that NLRP3-ASC pathway was activated by reactive oxygen species (ROS), since ROS scavenger of N-acetyl-cysteine (NAC) prevented, which was further reduced by PepE addition.	Reactive Oxygen Species	107-110	NLR family, pyrin domain containing 3	Mus musculus	35-40
30021379-8	2018	Further experiments indicated that NLRP3-ASC pathway was activated by reactive oxygen species (ROS), since ROS scavenger of N-acetyl-cysteine (NAC) prevented, which was further reduced by PepE addition.	Acetylcysteine	124-141	NLR family, pyrin domain containing 3	Mus musculus	35-40
30021379-8	2018	Further experiments indicated that NLRP3-ASC pathway was activated by reactive oxygen species (ROS), since ROS scavenger of N-acetyl-cysteine (NAC) prevented, which was further reduced by PepE addition.	Acetylcysteine	143-146	NLR family, pyrin domain containing 3	Mus musculus	35-40
29959134-5	2018	GL significantly improved MCD diet-induced hepatic steatosis, inflammation, and fibrosis and inhibited activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome.	Glycyrrhizic Acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	121-157
29959134-5	2018	GL significantly improved MCD diet-induced hepatic steatosis, inflammation, and fibrosis and inhibited activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome.	Glycyrrhizic Acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	159-164
29959134-7	2018	In Raw 264.7 macrophage cells, both GL and GA inhibited deoxycholic acid-induced NLRP3 inflammasome-associated inflammation.	Glycyrrhizic Acid	36-38	NLR family, pyrin domain containing 3	Mus musculus	81-86
29959134-7	2018	In Raw 264.7 macrophage cells, both GL and GA inhibited deoxycholic acid-induced NLRP3 inflammasome-associated inflammation.	Glycyrrhetinic Acid	43-45	NLR family, pyrin domain containing 3	Mus musculus	81-86
29959134-7	2018	In Raw 264.7 macrophage cells, both GL and GA inhibited deoxycholic acid-induced NLRP3 inflammasome-associated inflammation.	Deoxycholic Acid	56-72	NLR family, pyrin domain containing 3	Mus musculus	81-86
30186412-0	2018	Triiodothyronine alleviates alcoholic liver disease injury through the negative regulation of the NLRP3 signaling pathway.	Triiodothyronine	0-16	NLR family, pyrin domain containing 3	Mus musculus	98-103
30084831-0	2018	Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice.	Linoleic Acid	9-22	NLR family, pyrin domain containing 3	Mus musculus	90-95
30146006-6	2018	Further study showed that metronidazole- and vancomycin-sensitive bacteria are involved in maintenance of NLRP3/IL-1beta signal in pMphi.	Metronidazole	26-39	NLR family, pyrin domain containing 3	Mus musculus	106-111
30146006-6	2018	Further study showed that metronidazole- and vancomycin-sensitive bacteria are involved in maintenance of NLRP3/IL-1beta signal in pMphi.	Vancomycin	45-55	NLR family, pyrin domain containing 3	Mus musculus	106-111
30084831-8	2018	We also found increased levels of NOD-like receptor protein 3 (NLRP3) inflammasome components and Caspase-1 activation in the livers of OXLAM-fed mice.	oxlam	136-141	NLR family, pyrin domain containing 3	Mus musculus	34-61
30084831-8	2018	We also found increased levels of NOD-like receptor protein 3 (NLRP3) inflammasome components and Caspase-1 activation in the livers of OXLAM-fed mice.	oxlam	136-141	NLR family, pyrin domain containing 3	Mus musculus	63-68
30084831-10	2018	This study identified key mechanisms by which dietary OXLAMs contribute to NASH development, including mitochondrial dysfunction, hepatocyte cell death, and NLRP3 inflammasome activation.	oxlams	54-60	NLR family, pyrin domain containing 3	Mus musculus	157-162
29588315-2	2018	IL-1beta and IL-18 are produced via the NLRP3 inflammasome in myeloid cells in response to cholesterol accumulation, but mechanisms linking NLRP3 inflammasome activation to atherogenesis are unclear.	Cholesterol	91-102	NLR family, pyrin domain containing 3	Mus musculus	40-45
29859317-2	2018	Recently, a potent, selective, small-molecule NLRP3 inflammasome inhibitor, MCC950, was described.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	76-82	NLR family, pyrin domain containing 3	Mus musculus	46-51
30146016-0	2018	Icariin alleviates murine lupus nephritis via inhibiting NF-kappaB activation pathway and NLRP3 inflammasome.	icariin	0-7	NLR family, pyrin domain containing 3	Mus musculus	90-95
30146016-12	2018	Finally, icariin suppressed NLRP3 inflammasome activation and IL-1beta production in MRL/lpr mice.	icariin	9-16	NLR family, pyrin domain containing 3	Mus musculus	28-33
30146016-13	2018	SIGNIFICANCE: Icariin alleviated murine lupus nephritis via inhibiting NF-kappaB activation and NLRP3 inflammasome activation.	icariin	14-21	NLR family, pyrin domain containing 3	Mus musculus	96-101
29588315-12	2018	CONCLUSIONS: Cholesterol accumulation in myeloid cells activates the NLRP3 inflammasome, which enhances neutrophil accumulation and neutrophil extracellular trap formation in atherosclerotic plaques.	Cholesterol	13-24	NLR family, pyrin domain containing 3	Mus musculus	69-74
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Cobalt	41-47	NLR family, pyrin domain containing 3	Mus musculus	92-97
30224927-9	2018	Taken together, our results indicate that BSYZ alleviates MPTP-induced neuroinflammation probably via inhibiting NLRP3 inflammasome activation in microglia.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	58-62	NLR family, pyrin domain containing 3	Mus musculus	113-118
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Chromium	49-57	NLR family, pyrin domain containing 3	Mus musculus	92-97
30186184-11	2018	Tube length of thoracic aortic rings from NALP3-/- mice was longer than those from WT mice after receiving high-salt treatment.	Salts	112-116	NLR family, pyrin domain containing 3	Mus musculus	42-47
30138321-2	2018	Studies with macrophages have shown that cobalt, chromium, and nickel ions can activate the NLRP3 inflammasome, a multiprotein complex responsible for the activation of caspase-1 (a proteolytic enzyme converting pro-interleukin [IL]-1beta to mature IL-1beta).	Nickel	63-69	NLR family, pyrin domain containing 3	Mus musculus	92-97
30186184-12	2018	Inhibiting NALP3 with a NALP3 antagonist, small interfering (si) RNA experiments using si-NALP3, and decomposing ROS significantly improved tube formation ability in MAECs under high salt medium.	Silicon	61-63	NLR family, pyrin domain containing 3	Mus musculus	11-16
30107806-9	2018	In addition, corylin inhibited the expression of iNOS and COX-2, attenuated the phosphorylation of ERK, JNK and p38, decreased the expression of NLRP3 and ASC, and repressed the activation of caspase-1 and IL-1beta by LPS-activated BV2 cells.	corylin	13-20	NLR family, pyrin domain containing 3	Mus musculus	145-150
30186184-12	2018	Inhibiting NALP3 with a NALP3 antagonist, small interfering (si) RNA experiments using si-NALP3, and decomposing ROS significantly improved tube formation ability in MAECs under high salt medium.	Salts	183-187	NLR family, pyrin domain containing 3	Mus musculus	11-16
30186184-13	2018	NALP3 expression was increased in MAECs cultured with high salt treatment and inhibiting NALP3 reversed the down-regulation of p-eNOS induced by high salt in MAECs.	Salts	59-63	NLR family, pyrin domain containing 3	Mus musculus	0-5
30186184-13	2018	NALP3 expression was increased in MAECs cultured with high salt treatment and inhibiting NALP3 reversed the down-regulation of p-eNOS induced by high salt in MAECs.	Salts	150-154	NLR family, pyrin domain containing 3	Mus musculus	0-5
30186184-13	2018	NALP3 expression was increased in MAECs cultured with high salt treatment and inhibiting NALP3 reversed the down-regulation of p-eNOS induced by high salt in MAECs.	Salts	150-154	NLR family, pyrin domain containing 3	Mus musculus	89-94
30186184-14	2018	Conclusion: High salt intake impairs endothelial function, which is at least in part mediated by increasing NALP3 expression.	Salts	17-21	NLR family, pyrin domain containing 3	Mus musculus	108-113
30186288-0	2018	Repositioning of the beta-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome.	Carvedilol	34-44	NLR family, pyrin domain containing 3	Mus musculus	92-97
30126430-9	2018	GSK872 significantly suppressed the activation of necroptosis and NLRP3 activation with reduction of IL-1beta and IL-18 production and inflammatory cells infiltration, resulting in a significant amelioration of lung injury.	GSK872	0-6	NLR family, pyrin domain containing 3	Mus musculus	66-71
30126430-12	2018	This RIP3-NLRP3 interaction was significantly inhibited by GSK872.	GSK872	59-65	NLR family, pyrin domain containing 3	Mus musculus	10-15
29913124-0	2018	Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome.	astragaloside	22-35	NLR family, pyrin domain containing 3	Mus musculus	126-131
30186184-0	2018	Inflammasome-Independent NALP3 Contributes to High-Salt Induced Endothelial Dysfunction.	Salts	51-55	NLR family, pyrin domain containing 3	Mus musculus	25-30
30186184-5	2018	Thus, this study was designed to investigate the possible mechanisms of NALP3 in high salt induced endothelial dysfunction.	Salts	86-90	NLR family, pyrin domain containing 3	Mus musculus	72-77
29907905-4	2018	We also found that the release of adenosine triphosphate (ATP) was increased post smoke exposure, while oxidized ATP, an inhibitor of purinergic P2X7 receptor, suppressed smoke-induced NALP3 inflammasome assembly, caspase-1 activation, and K+ efflux.	Adenosine Triphosphate	58-61	NLR family, pyrin domain containing 3	Mus musculus	185-190
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	238-265	NLR family, pyrin domain containing 3	Mus musculus	68-73
29920250-5	2018	Nuclear factor kappa B (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome-associated protein expressions and inflammatory cytokine (IL-1beta and IL-18) release were detected in the presence or absence of NF-kappaB inhibitor pyrrolidine dithiocarbamate (PDTC).	pyrrolidine dithiocarbamic acid	267-271	NLR family, pyrin domain containing 3	Mus musculus	68-73
29907905-4	2018	We also found that the release of adenosine triphosphate (ATP) was increased post smoke exposure, while oxidized ATP, an inhibitor of purinergic P2X7 receptor, suppressed smoke-induced NALP3 inflammasome assembly, caspase-1 activation, and K+ efflux.	Adenosine Triphosphate	113-116	NLR family, pyrin domain containing 3	Mus musculus	185-190
30047025-0	2018	Sophocarpine attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-kappaB activation.	sophocarpine	0-12	NLR family, pyrin domain containing 3	Mus musculus	62-67
29264825-0	2018	Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation.	Fenofibrate	0-11	NLR family, pyrin domain containing 3	Mus musculus	78-83
30047025-10	2018	Sophocarpine treatment reduced the levels of proteins that form NLRP3 inflammasome.	sophocarpine	0-12	NLR family, pyrin domain containing 3	Mus musculus	64-69
29737568-0	2018	Pterostilbene inhibits amyloid-beta-induced neuroinflammation in a microglia cell line by inactivating the NLRP3/caspase-1 inflammasome pathway.	pterostilbene	0-13	NLR family, pyrin domain containing 3	Mus musculus	107-112
29737568-8	2018	Abeta1-42 activated NLRP3/caspase-1 inflammasome, which was inactivated by pterostilbene.	pterostilbene	75-88	NLR family, pyrin domain containing 3	Mus musculus	20-25
29737568-10	2018	In conclusion, pterostilbene attenuated the neuroinflammatory response induced by Abeta1-42 in microglia through inhibiting the NLRP3/caspase-1 inflammasome pathway, indicating that pterostilbene might be an effective therapy for AD.	pterostilbene	15-28	NLR family, pyrin domain containing 3	Mus musculus	128-133
29264825-5	2018	The purpose of this study is to determine whether fenofibrate protects retinas from oxidative damage and neuroinflammation via modulating the Nrf2 pathway and blocking NLRP3 inflammasome activation during diabetes.	Fenofibrate	50-61	NLR family, pyrin domain containing 3	Mus musculus	168-173
29682880-9	2018	FSL-1 as well as the representative NLRP3 inflammasome activator nigericin induced the NLRP3/ASC speck, but FSL-1 located in a compartment different from the NLRP3/ASC speck.	Nigericin	65-74	NLR family, pyrin domain containing 3	Mus musculus	36-41
29264825-11	2018	In addition, retinal expression of NLRP3, Caspase-1 p20, IL-1beta p17, and ICAM-1 were dramatically increased in vehicle-treated diabetic mice, which were abolished by fenofibrate intervention.	Fenofibrate	168-179	NLR family, pyrin domain containing 3	Mus musculus	35-40
29682880-9	2018	FSL-1 as well as the representative NLRP3 inflammasome activator nigericin induced the NLRP3/ASC speck, but FSL-1 located in a compartment different from the NLRP3/ASC speck.	Nigericin	65-74	NLR family, pyrin domain containing 3	Mus musculus	87-92
29264825-13	2018	Taken together, fenofibrate attenuates oxidative stress and neuroinflammation in diabetic retinas, which is at least partially through modulating Nrf2 expression and NLRP3 inflammasome activation.	Fenofibrate	16-27	NLR family, pyrin domain containing 3	Mus musculus	166-171
29682880-9	2018	FSL-1 as well as the representative NLRP3 inflammasome activator nigericin induced the NLRP3/ASC speck, but FSL-1 located in a compartment different from the NLRP3/ASC speck.	Nigericin	65-74	NLR family, pyrin domain containing 3	Mus musculus	87-92
30140364-5	2018	In in vitro studies, palmitic acid (PA) was found to increase colocalization of NLRP3 components and enhanced caspase-1 activity in hepatic stellate cells (HSCs), indicating enhanced formation and activation of NLRP3 inflammasomes by PA.	Palmitic Acid	234-236	NLR family, pyrin domain containing 3	Mus musculus	211-216
30017113-4	2018	Therefore, we synthesized some 1,5-AF derivatives that would not be able to form the dimer conformation and can be expected to have high activity against inflammasome, and then evaluated their inhibitory activities with respect to the NLRP3 inflammasome by using mouse bone marrow-derived macrophages and human THP-1 cells.	1,5-anhydrofructose	31-37	NLR family, pyrin domain containing 3	Mus musculus	235-240
30150895-0	2018	Corrigendum to "Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways".	naringenin	16-26	NLR family, pyrin domain containing 3	Mus musculus	101-106
30140364-0	2018	NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ.	CHEMBL1354522	130-133	NLR family, pyrin domain containing 3	Mus musculus	0-5
30140364-4	2018	FTZ extracts not only significantly reduced the NLRP3 inflammasome formation and activation but also attenuated the liver steatosis and fibrogenic phenotype changed.	CHEMBL1354522	0-3	NLR family, pyrin domain containing 3	Mus musculus	48-53
30140364-5	2018	In in vitro studies, palmitic acid (PA) was found to increase colocalization of NLRP3 components and enhanced caspase-1 activity in hepatic stellate cells (HSCs), indicating enhanced formation and activation of NLRP3 inflammasomes by PA.	Palmitic Acid	21-34	NLR family, pyrin domain containing 3	Mus musculus	80-85
30140364-7	2018	Nlrp3 siRNA can reverse this effect by silencing the NLRP3 inflammasome and both with FTZ.	CHEMBL1354522	86-89	NLR family, pyrin domain containing 3	Mus musculus	0-5
30140364-5	2018	In in vitro studies, palmitic acid (PA) was found to increase colocalization of NLRP3 components and enhanced caspase-1 activity in hepatic stellate cells (HSCs), indicating enhanced formation and activation of NLRP3 inflammasomes by PA.	Palmitic Acid	21-34	NLR family, pyrin domain containing 3	Mus musculus	211-216
30140364-10	2018	Mechanistically, stimulated membrane raft redox signaling platform formation and increased O2 - production by PA to activate NLRP3 inflammasomes in HSCs was blocked by FTZ treatment.	Oxygen	91-93	NLR family, pyrin domain containing 3	Mus musculus	125-130
30140364-5	2018	In in vitro studies, palmitic acid (PA) was found to increase colocalization of NLRP3 components and enhanced caspase-1 activity in hepatic stellate cells (HSCs), indicating enhanced formation and activation of NLRP3 inflammasomes by PA.	Palmitic Acid	36-38	NLR family, pyrin domain containing 3	Mus musculus	80-85
30140364-5	2018	In in vitro studies, palmitic acid (PA) was found to increase colocalization of NLRP3 components and enhanced caspase-1 activity in hepatic stellate cells (HSCs), indicating enhanced formation and activation of NLRP3 inflammasomes by PA.	Palmitic Acid	36-38	NLR family, pyrin domain containing 3	Mus musculus	211-216
30140364-10	2018	Mechanistically, stimulated membrane raft redox signaling platform formation and increased O2 - production by PA to activate NLRP3 inflammasomes in HSCs was blocked by FTZ treatment.	Palmitic Acid	110-112	NLR family, pyrin domain containing 3	Mus musculus	125-130
30140364-10	2018	Mechanistically, stimulated membrane raft redox signaling platform formation and increased O2 - production by PA to activate NLRP3 inflammasomes in HSCs was blocked by FTZ treatment.	CHEMBL1354522	168-171	NLR family, pyrin domain containing 3	Mus musculus	125-130
30140364-11	2018	It is concluded that FTZ extracts inhibit NASH by its action on both inflammatory response and liver lipid metabolism associated with NLRP3 inflammasome formation and activation.	CHEMBL1354522	21-24	NLR family, pyrin domain containing 3	Mus musculus	134-139
30140371-0	2018	Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	103-108
30140371-6	2018	In addition, salidroside suppressed oxidative stress, thioredoxin-interacting protein (TXNIP) expression, and NLRP3 inflammasome activation in the liver.	rhodioloside	13-24	NLR family, pyrin domain containing 3	Mus musculus	110-115
30036952-0	2018	Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusion Injury via Modulation of the TLR4/NF-kappaB and NLRP3 Pathways.	Anthocyanins	14-25	NLR family, pyrin domain containing 3	Mus musculus	130-135
30140371-7	2018	In cultured hepatocytes, salidroside dose dependently regulated lipid accumulation, reactive oxygen species (ROS) generation, and NLRP3 inflammasome activation as well as improved AMP-activated protein kinase (AMPK) activity and insulin sensitivity.	rhodioloside	25-36	NLR family, pyrin domain containing 3	Mus musculus	130-135
30140371-9	2018	Our findings demonstrated that salidroside protects against NAFLD by improving hepatic lipid metabolism and NLRP3 inflammasome activation, and these actions are related to the regulation of the oxidative stress and AMPK-dependent TXNIP/NLRP3 pathways.	rhodioloside	31-42	NLR family, pyrin domain containing 3	Mus musculus	108-113
30140371-9	2018	Our findings demonstrated that salidroside protects against NAFLD by improving hepatic lipid metabolism and NLRP3 inflammasome activation, and these actions are related to the regulation of the oxidative stress and AMPK-dependent TXNIP/NLRP3 pathways.	rhodioloside	31-42	NLR family, pyrin domain containing 3	Mus musculus	236-241
30005632-7	2018	The combination of heat stress with rehydration with fructose was associated with increased intrarenal expression of the inflammasome markers, NLRP3 and IL-18, compared to heat stress alone.	Fructose	53-61	NLR family, pyrin domain containing 3	Mus musculus	143-148
29958799-1	2018	Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive.	Potassium	0-9	NLR family, pyrin domain containing 3	Mus musculus	105-110
29958799-1	2018	Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive.	Adenosine Triphosphate	93-96	NLR family, pyrin domain containing 3	Mus musculus	105-110
29954866-7	2018	Moreover, treatment with the NLRP3-inflammasome inhibitor MCC950 alongside antimalarial drugs phenocopied the protective effect of IL33 therapy in improving the recovery from established ECM.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	58-64	NLR family, pyrin domain containing 3	Mus musculus	29-34
29929367-4	2018	25-OCH3-PPD decreases serum ALT/AST levels and improves the histological pathology of liver in TAA-induced mice; attenuates transcripts of pro-fibrogenic markers associated with hepatic stellate cell activation; attenuates the levels of pro-Inflammatory cytokines and blocks apoptosis happened in liver; inhibits NLRP3 inflammasome by affecting P2X7R activation; and regulates PI3K/Akt and LKB1/AMPK-SIRT1.	25-methoxylprotopanaxadiol	0-11	NLR family, pyrin domain containing 3	Mus musculus	313-318
29906245-5	2018	KC depletion partly prevented the antiinflammatory effects of indole, notably through a reduction of nucleotide-binding domain and leucine-rich repeat containing (NLR) family pyrin domain-containing 3 (NLRP3) pathway activation.	indole	62-68	NLR family, pyrin domain containing 3	Mus musculus	131-200
29769270-8	2018	These data thus demonstrate that GLA-SE adjuvanticity acts through TLR4 signaling and NLRP3 inflammasome activation to promote robust Th1 and B cell responses to vaccine Ags.	gamma-Linolenic Acid	33-36	NLR family, pyrin domain containing 3	Mus musculus	86-91
29966531-6	2018	METHODS: In the present study, we detected the NLRP3 expressions in the midbrain, liver, and bone marrow-derived macrophages in response to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) acute and chronic challenge.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	140-187	NLR family, pyrin domain containing 3	Mus musculus	47-52
29966531-6	2018	METHODS: In the present study, we detected the NLRP3 expressions in the midbrain, liver, and bone marrow-derived macrophages in response to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) acute and chronic challenge.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	189-193	NLR family, pyrin domain containing 3	Mus musculus	47-52
29874961-0	2018	Procyanidin B2 prevents lupus nephritis development in mice by inhibiting NLRP3 inflammasome activation.	procyanidin B2	0-14	NLR family, pyrin domain containing 3	Mus musculus	74-79
29783158-0	2018	Pirfenidone ameliorates lipopolysaccharide-induced pulmonary inflammation and fibrosis by blocking NLRP3 inflammasome activation.	pirfenidone	0-11	NLR family, pyrin domain containing 3	Mus musculus	99-104
29783158-3	2018	Our present study aims to assess whether pirfenidone,with anti-fibrotic and anti-inflammatory properties, can improve LPS-induced inflammation and fibrosis by inhibiting NLRP3 inflammasome activation.	pirfenidone	41-52	NLR family, pyrin domain containing 3	Mus musculus	170-175
29783158-8	2018	Pirfenidone substantially reduced NLRP3 and ASC expression and inhibited caspase-1 activation and IL-1beta maturation in lung tissues.	pirfenidone	0-11	NLR family, pyrin domain containing 3	Mus musculus	34-39
29906245-5	2018	KC depletion partly prevented the antiinflammatory effects of indole, notably through a reduction of nucleotide-binding domain and leucine-rich repeat containing (NLR) family pyrin domain-containing 3 (NLRP3) pathway activation.	indole	62-68	NLR family, pyrin domain containing 3	Mus musculus	202-207
29891042-11	2018	CONCLUSIONS: TSG attenuates high glucose-induced cell apoptosis in vitro partly through the suppression of NLRP3 inflammasome signaling.	Glucose	33-40	NLR family, pyrin domain containing 3	Mus musculus	107-112
29872077-0	2018	MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	47-52
29896426-6	2018	More interestingly, the high cholesterol diet not only improved NLRP3 inflammasome activation and IL-1beta expression, but also increased levels of anti-inflammatory cytokines IL-4 and IL-6 in the hippocampus of old mice, suggesting playing pro- and anti-neuroinflammatory effects.	Cholesterol	29-40	NLR family, pyrin domain containing 3	Mus musculus	64-69
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	Oxaloacetic Acid	10-13	NLR family, pyrin domain containing 3	Mus musculus	200-205
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Fatty Acids, Volatile	46-51	NLR family, pyrin domain containing 3	Mus musculus	108-140
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Fatty Acids, Volatile	46-51	NLR family, pyrin domain containing 3	Mus musculus	142-147
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Acetates	53-60	NLR family, pyrin domain containing 3	Mus musculus	108-140
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Acetates	53-60	NLR family, pyrin domain containing 3	Mus musculus	142-147
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Propionates	62-72	NLR family, pyrin domain containing 3	Mus musculus	108-140
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Propionates	62-72	NLR family, pyrin domain containing 3	Mus musculus	142-147
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Butyrates	77-85	NLR family, pyrin domain containing 3	Mus musculus	108-140
29475132-3	2018	The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation.	Butyrates	77-85	NLR family, pyrin domain containing 3	Mus musculus	142-147
29475132-4	2018	Using a partial ligated carotid artery (PLCA) mouse model fed with the Western diet (WD), we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/-).	Butyrates	104-112	NLR family, pyrin domain containing 3	Mus musculus	137-142
29475132-5	2018	Nevertheless, both acetate and propionate markedly enhanced the formation and activation of the Nlrp3 inflammasome as well as carotid neointima formation in the carotid arteries with PLCA in Asc+/+, but not Asc-/- mice.	Acetates	19-26	NLR family, pyrin domain containing 3	Mus musculus	96-101
29475132-5	2018	Nevertheless, both acetate and propionate markedly enhanced the formation and activation of the Nlrp3 inflammasome as well as carotid neointima formation in the carotid arteries with PLCA in Asc+/+, but not Asc-/- mice.	Propionates	31-41	NLR family, pyrin domain containing 3	Mus musculus	96-101
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	Butyrates	30-38	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	Butyrates	30-38	NLR family, pyrin domain containing 3	Mus musculus	225-230
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	Butyrates	30-38	NLR family, pyrin domain containing 3	Mus musculus	225-230
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	138-155	NLR family, pyrin domain containing 3	Mus musculus	107-112
29891042-0	2018	Tetrahydroxy Stilbene Glucoside Alleviates High Glucose-Induced MPC5 Podocytes Injury Through Suppression of NLRP3 Inflammasome.	tetrahydroxy stilbene glucoside	0-31	NLR family, pyrin domain containing 3	Mus musculus	109-114
29891042-0	2018	Tetrahydroxy Stilbene Glucoside Alleviates High Glucose-Induced MPC5 Podocytes Injury Through Suppression of NLRP3 Inflammasome.	Glucose	48-55	NLR family, pyrin domain containing 3	Mus musculus	109-114
28349253-3	2018	METHODS: Palmitate challenge evoked ROS-associated endoplasmic reticulum stress (ER stress) and NLRP3 inflammasome activation in PVAT.	Palmitates	9-18	NLR family, pyrin domain containing 3	Mus musculus	96-101
28349253-6	2018	Moreover, Mangiferin restored insulin-mediated Akt and eNOS phosphorylations with increased NO production, immunohistochemistry examination of adipocytes, and endothelial tissue in high-fat diet-fed mice also showed that oral administration of Mangiferin inhibited ER stress and NLRP3 induction in PVAT, and then effectively prevented insulin resistance in the vessel endothelium.	mangiferin	10-20	NLR family, pyrin domain containing 3	Mus musculus	279-284
29574653-8	2018	Moreover, the levels of epoxyeicosatrienoic acids and heme oxygenase-1 activity were notably elevated in sEH-/- mice compared with those in wild-type mice after exposure to 100% O2 for 72 h. The nucleotide-binding domains and leucine-rich repeat pyrin domains containing 3 (NLRP3) inflammasome activation and caspase-1 activity induced by hyperoxia were inhibited in sEH-/- mice compared with those in wild-type mice.	Oxygen	178-180	NLR family, pyrin domain containing 3	Mus musculus	274-279
29295651-2	2018	This study aims to examine whether specific modulation of NLPR3 inflammasome by MCC950, a novel selective NLRP3 inhibitor, confers protection after experimental TBI.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	80-86	NLR family, pyrin domain containing 3	Mus musculus	106-111
29998123-1	2018	Background: We previously reported that the NLRP3 inflammasome played an important role in mediating the podocyte injury induced by aldosterone.	Aldosterone	132-143	NLR family, pyrin domain containing 3	Mus musculus	44-49
29505886-4	2018	Moreover, OAA treatment significantly decreased the elevations of IL-1beta, IL-6, TNF-alpha, TGF-beta1, and fibronectin, and the activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the lungs of PHMG-P-treated mice.	polyhexamethyleneguanidine	236-242	NLR family, pyrin domain containing 3	Mus musculus	200-205
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	157-162	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	Cholesterol	144-155	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	Acetates	201-208	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-6	2018	In cultured ECs (EOMA cells), butyrate was found to significantly decrease the formation and activation of Nlrp3 inflammasomes induced by 7-ketocholesterol (7-Ket) or cholesterol crystals (CHC), while acetate did not inhibit Nlrp3 inflammasome activation induced by either 7-Ket or CHC, but itself even activated Nlrp3 inflammsomes.	7-ketocholesterol	273-278	NLR family, pyrin domain containing 3	Mus musculus	107-112
29475132-7	2018	Mechanistically, the inhibitory action of butyrate on the Nlrp3 inflammasome was attributed to a blockade of lipid raft redox signaling platforms to produce O2 - upon 7-Ket or CHC stimulations.	Butyrates	42-50	NLR family, pyrin domain containing 3	Mus musculus	58-63
29475132-7	2018	Mechanistically, the inhibitory action of butyrate on the Nlrp3 inflammasome was attributed to a blockade of lipid raft redox signaling platforms to produce O2 - upon 7-Ket or CHC stimulations.	Oxygen	157-159	NLR family, pyrin domain containing 3	Mus musculus	58-63
29722780-8	2018	Furthermore, experiments indicated that MSNs induced mitochondrial reactive oxygen species (ROS) generation, and the ROS scavenger could attenuate the MSN-activated NLRP3 inflammasomes and pyroptosis in the liver.	Reactive Oxygen Species	117-120	NLR family, pyrin domain containing 3	Mus musculus	165-170
29863661-12	2018	In this manuscript, we show that activation of the NLRP3 inflammasome by nigericin leads to the co-localization of the adaptor protein ASC and active caspase-1, leading to pyroptosis.	Nigericin	73-82	NLR family, pyrin domain containing 3	Mus musculus	51-56
29722780-9	2018	Collectively, these data suggested that MSNs triggered liver inflammation and hepatocyte pyroptosis through NLRP3 inflammasome activation, which was caused by MSN-induced ROS generation.	Reactive Oxygen Species	171-174	NLR family, pyrin domain containing 3	Mus musculus	108-113
29523554-4	2018	Reduced synthesis of 25-hydroxycholesterol after LIPA inhibition contributed to defective mitochondria-associated membrane leading to mitochondrial oxidative stress-induced NLRP3 (NOD-like receptor family, pyrin domain containing) inflammasome activation and caspase-1-dependent Rac1 (Ras-related C3 botulinum toxin substrate 1) degradation.	25-hydroxycholesterol	21-42	NLR family, pyrin domain containing 3	Mus musculus	173-178
29421335-0	2018	NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	47-51	NLR family, pyrin domain containing 3	Mus musculus	0-5
29421335-10	2018	These results suggested that MPTP was toxic to mouse thymus via a mechanism involving the NF-kappaB and NLRP3 inflammasome pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	29-33	NLR family, pyrin domain containing 3	Mus musculus	104-109
29609129-7	2018	Moreover, lidocaine abrogated the increased concentrations of T cytokines and TNF-alpha in bronchoalveolar lavage fluid (BALF) of allergic mice, as well as reducing the expression of phosphorylated nuclear factor (P-NF)-kappaBp65 and the NOD-like receptor pyridine containing 3 (NLRP3), which are important for the production of pro-inflammatory cytokines.	Lidocaine	10-19	NLR family, pyrin domain containing 3	Mus musculus	238-277
29773990-7	2018	Atorvastatin could also inhibit NLRP3 inflammasome activation and inflammatory cytokines, such as IL-1beta, TNF-alpha, and IL-18 secretion in vivo.	Atorvastatin	0-12	NLR family, pyrin domain containing 3	Mus musculus	32-37
29773990-10	2018	We employed oxidized low-density lipoprotein (ox-LDL) to stimulate RAW264.7 cells with atorvastatin, which showed that atorvastatin could attenuate lipid deposition, ameliorate inflammation, inhibit NLRP3 inflammasome activation, and enhance autophagy in vitro.	Atorvastatin	87-99	NLR family, pyrin domain containing 3	Mus musculus	199-204
29773990-10	2018	We employed oxidized low-density lipoprotein (ox-LDL) to stimulate RAW264.7 cells with atorvastatin, which showed that atorvastatin could attenuate lipid deposition, ameliorate inflammation, inhibit NLRP3 inflammasome activation, and enhance autophagy in vitro.	Atorvastatin	119-131	NLR family, pyrin domain containing 3	Mus musculus	199-204
29854830-1	2018	We recently have proved that excessive fecal DCA caused by high-fat diet may serve as an endogenous danger-associated molecular pattern to activate NLRP3 inflammasome and thus contributes to the development of inflammatory bowel disease (IBD).	Dichloroacetic Acid	45-48	NLR family, pyrin domain containing 3	Mus musculus	148-153
29854830-5	2018	Meanwhile, DCA-induced NLRP3 inflammasome activation is at least partially achieved through stimulating extracellular regulated protein kinases (ERK) signaling pathway downstream of S1PR2 followed by promoting of lysosomal cathepsin B release.	Dichloroacetic Acid	11-14	NLR family, pyrin domain containing 3	Mus musculus	23-28
29518608-8	2018	NLR family, pyrin domain-containing 3 (NLRP3) inflammasome was also suppressed by RIP3 knockout in potassium oxonate-treated mice.	potassium oxonate	99-116	NLR family, pyrin domain containing 3	Mus musculus	0-37
29518608-8	2018	NLR family, pyrin domain-containing 3 (NLRP3) inflammasome was also suppressed by RIP3 knockout in potassium oxonate-treated mice.	potassium oxonate	99-116	NLR family, pyrin domain containing 3	Mus musculus	39-44
29771438-0	2018	Methylene blue attenuates renal ischemia-reperfusion injury by negative regulation of NLRP3 signaling pathway.	Methylene Blue	0-14	NLR family, pyrin domain containing 3	Mus musculus	86-91
29771438-16	2018	CONCLUSIONS: We showed that methylene blue can alleviate the apoptosis and inflammatory response induced by renal IR injury in mice, and its relevant mechanism may be related to the fact that methylene blue can negatively regulate NLRP3 signaling pathway.	Methylene Blue	28-42	NLR family, pyrin domain containing 3	Mus musculus	231-236
29771438-16	2018	CONCLUSIONS: We showed that methylene blue can alleviate the apoptosis and inflammatory response induced by renal IR injury in mice, and its relevant mechanism may be related to the fact that methylene blue can negatively regulate NLRP3 signaling pathway.	Methylene Blue	192-206	NLR family, pyrin domain containing 3	Mus musculus	231-236
29456024-6	2018	RESULTS: Flagellin A N/C inhibited radiation-induced reactive oxygen species production, decreased NLRP3 activity, and reduced the occurrence of caspase-1-dependent pyroptosis.	flagellin a	9-20	NLR family, pyrin domain containing 3	Mus musculus	99-104
29456024-8	2018	Flagellin A N/C exerted a protective effect by blunting the activation of NLRP3 inflammasome signaling, thereby reducing the inflammatory response and occurrence of caspase-1-dependent pyroptosis in the intestine.	flagellin a	0-11	NLR family, pyrin domain containing 3	Mus musculus	74-79
29456024-10	2018	CONCLUSIONS: Reactive oxygen species-induced NLRP3 inflammasomes mediated radiation-induced pyroptosis of the intestinal cells, and FlaAN/C suppressed pyroptosis to protect the intestinal tissue.	Reactive Oxygen Species	13-36	NLR family, pyrin domain containing 3	Mus musculus	45-50
29602772-4	2018	In this article, we show that mouse NLRP3 and caspase-1 independently interact with the mitochondrial lipid cardiolipin, which is externalized to the outer mitochondrial membrane at priming in response to reactive oxygen species.	Reactive Oxygen Species	205-228	NLR family, pyrin domain containing 3	Mus musculus	36-41
29602772-5	2018	An NLRP3 activation signal is then required for the calcium-dependent association of the adaptor molecule ASC with NLRP3 on the mitochondrial surface, resulting in inflammasome complex assembly and activation.	Calcium	52-59	NLR family, pyrin domain containing 3	Mus musculus	3-8
29602772-5	2018	An NLRP3 activation signal is then required for the calcium-dependent association of the adaptor molecule ASC with NLRP3 on the mitochondrial surface, resulting in inflammasome complex assembly and activation.	Calcium	52-59	NLR family, pyrin domain containing 3	Mus musculus	115-120
29863012-17	2018	These findings suggest that dexmedetomidine exhibits neuroprotective effects against acute (3 days) post-traumatic inflammatory responses, potentially via suppression of NF-kappaB and NLRP3 inflammasome activation.	Dexmedetomidine	28-43	NLR family, pyrin domain containing 3	Mus musculus	184-189
29609129-7	2018	Moreover, lidocaine abrogated the increased concentrations of T cytokines and TNF-alpha in bronchoalveolar lavage fluid (BALF) of allergic mice, as well as reducing the expression of phosphorylated nuclear factor (P-NF)-kappaBp65 and the NOD-like receptor pyridine containing 3 (NLRP3), which are important for the production of pro-inflammatory cytokines.	Lidocaine	10-19	NLR family, pyrin domain containing 3	Mus musculus	279-284
29609129-10	2018	However, lidocaine effectively inhibited airway inflammation and counteracted the expression of P-NF-kappaBp65 and NLRP3 in allergic mice pretreated with Pam3CSK4.	Lidocaine	9-18	NLR family, pyrin domain containing 3	Mus musculus	115-120
29549176-0	2018	Curcumin Suppresses IL-1beta Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	91-96
29849929-0	2018	Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling.	2,2',4,4'-tetrabromodiphenyl ether	42-48	NLR family, pyrin domain containing 3	Mus musculus	97-102
29665808-0	2018	Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment.	Isoflurane	58-68	NLR family, pyrin domain containing 3	Mus musculus	17-22
29665808-3	2018	This study is carried out to determine the critical role of the NOD-like receptor protein 3 (NLRP3)-caspase-1 pathway in isoflurane-induced cognitive impairment.	Isoflurane	121-131	NLR family, pyrin domain containing 3	Mus musculus	64-91
29665808-3	2018	This study is carried out to determine the critical role of the NOD-like receptor protein 3 (NLRP3)-caspase-1 pathway in isoflurane-induced cognitive impairment.	Isoflurane	121-131	NLR family, pyrin domain containing 3	Mus musculus	93-98
29665808-13	2018	Isoflurane activated NLRP3-caspase-1 pathway and increased the secretion of IL-18 and IL-1beta in cells pretreated with lipopolysaccharide but not in cells without pretreatment.	Isoflurane	0-10	NLR family, pyrin domain containing 3	Mus musculus	21-26
29665808-14	2018	Downregulation of NLRP3 attenuated the activation of NLRP3 inflammasome by isoflurane.	Isoflurane	75-85	NLR family, pyrin domain containing 3	Mus musculus	18-23
29665808-14	2018	Downregulation of NLRP3 attenuated the activation of NLRP3 inflammasome by isoflurane.	Isoflurane	75-85	NLR family, pyrin domain containing 3	Mus musculus	53-58
29665808-15	2018	CONCLUSIONS: NLRP3 priming status in aged mouse brain may be involved in isoflurane-induced hippocampal inflammation and cognitive impairment.	Isoflurane	73-83	NLR family, pyrin domain containing 3	Mus musculus	13-18
29853850-5	2018	Diabetic mice received MCC950 (the specific molecule NLRP3 inhibitor) or vehicle 60 minutes before the middle cerebral artery occlusion (MCAO) and reperfusion.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	23-29	NLR family, pyrin domain containing 3	Mus musculus	53-58
29853850-9	2018	MCC950, the NLRP3 specific inhibitor, ameliorated diabetic mice with cerebral ischemia-reperfusion injury and improved the 28-day survival rate during the recovery stage of ischemic stroke.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	12-17
29849583-1	2018	Objective: This study is aimed at investigating whether exenatide (Exe) delays the progression of nonalcoholic fatty liver disease (NAFLD) in C57BL/6 mice by targeting the NLRP3 inflammasome through the autophagy/mitophagy pathway.	Exenatide	56-65	NLR family, pyrin domain containing 3	Mus musculus	172-177
29849583-1	2018	Objective: This study is aimed at investigating whether exenatide (Exe) delays the progression of nonalcoholic fatty liver disease (NAFLD) in C57BL/6 mice by targeting the NLRP3 inflammasome through the autophagy/mitophagy pathway.	Exenatide	67-70	NLR family, pyrin domain containing 3	Mus musculus	172-177
29549176-5	2018	The inhibitory effect of curcumin on inflammasome activation was specific to the NLRP3, not to the NLRC4 or the AIM2 inflammasomes.	Curcumin	25-33	NLR family, pyrin domain containing 3	Mus musculus	81-86
29476863-10	2018	NALP3 inflammasome activation was detected in the PHMG-P group until 4 weeks, which is suspected to be the main reason for the persistent inflammatory response and exacerbation of fibrotic changes.	polyhexamethyleneguanidine	50-56	NLR family, pyrin domain containing 3	Mus musculus	0-5
29549176-6	2018	Curcumin inhibited the NLRP3 inflammasome by preventing K+ efflux and disturbing the downstream events, including the efficient spatial arrangement of mitochondria, ASC oligomerization, and speckle formation.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	23-28
29549176-10	2018	Taken together, we identified curcumin as a common NLRP3 inflammasome activation inhibitor.	Curcumin	30-38	NLR family, pyrin domain containing 3	Mus musculus	51-56
29549176-11	2018	Our findings reveal a mechanism through which curcumin represses inflammation and suggest the potential clinical use of curcumin in NLRP3-driven diseases.	Curcumin	120-128	NLR family, pyrin domain containing 3	Mus musculus	132-137
29849486-0	2018	Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways.	naringenin	0-10	NLR family, pyrin domain containing 3	Mus musculus	85-90
29654318-2	2018	We therefore hypothesized that MCC950, a selective NLRP3-inflammasome inhibitor provides protection in mouse model of transient middle cerebral artery occlusion (tMCAO).	tmcao	162-167	NLR family, pyrin domain containing 3	Mus musculus	51-56
29692782-9	2018	Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA-induced hepatitis.	Reactive Oxygen Species	14-17	NLR family, pyrin domain containing 3	Mus musculus	55-60
29692782-9	2018	Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA-induced hepatitis.	Reactive Oxygen Species	14-17	NLR family, pyrin domain containing 3	Mus musculus	164-169
29692782-9	2018	Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA-induced hepatitis.	Acetylcysteine	21-38	NLR family, pyrin domain containing 3	Mus musculus	55-60
29692782-9	2018	Scavenging of ROS by N-acetyl-cysteine also attenuated NLRP3 inflammasome activation and liver inflammation, indicating that the essential role of ROS in mediating NLRP3 inflammasome activation in ConA-induced hepatitis.	Reactive Oxygen Species	147-150	NLR family, pyrin domain containing 3	Mus musculus	164-169
29654318-2	2018	We therefore hypothesized that MCC950, a selective NLRP3-inflammasome inhibitor provides protection in mouse model of transient middle cerebral artery occlusion (tMCAO).	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	31-37	NLR family, pyrin domain containing 3	Mus musculus	51-56
29355515-0	2018	Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1beta in Mice.	Alcohols	47-54	NLR family, pyrin domain containing 3	Mus musculus	88-93
30788937-14	2018	CONCLUSIONS: Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and its mechanism may be associated with inhibiting NLRP3 inflammasome activation, reducing IL-1beta generation and alleviating myocardial inflammatory injury.	ursolic acid	13-25	NLR family, pyrin domain containing 3	Mus musculus	217-222
29437575-0	2018	Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages.	Fatty Acids	0-21	NLR family, pyrin domain containing 3	Mus musculus	77-82
29508169-18	2018	mRNA levels of NALP3, ASC, IL-1beta, IL-6, caspase-1, TNF-alpha, collagen-1, and collagen-3 significantly increased in the kidneys of the BTBR compared to the WT mice.	btbr	138-142	NLR family, pyrin domain containing 3	Mus musculus	15-20
29447945-0	2018	Salmeterol, agonist of beta2-aderenergic receptor, prevents systemic inflammation via inhibiting NLRP3 inflammasome.	Salmeterol Xinafoate	0-10	NLR family, pyrin domain containing 3	Mus musculus	97-102
29447945-6	2018	We found that Salmeterol (10-10 M-10-7 M) prevented the cleavage of caspase-1 and the activation of NLRP3 inflammasome, reduced the release of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in vitro.	Salmeterol Xinafoate	14-24	NLR family, pyrin domain containing 3	Mus musculus	100-105
29447945-9	2018	These findings imply that Salmeterol at low concentrations (10-10 M-10-7 M) shows anti-inflammatory effect via inhibiting NLRP3 inflammasome.	Salmeterol Xinafoate	26-36	NLR family, pyrin domain containing 3	Mus musculus	122-127
29277561-1	2018	BACKGROUND &amp; AIMS: The innate immune system responds not only to bacterial signals, but also to non-infectious danger-associated molecular patterns that activate the NLRP3 inflammasome complex after tissue injury.	Adenosine Monophosphate	12-15	NLR family, pyrin domain containing 3	Mus musculus	170-175
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	51-56
29393339-3	2018	The objective of the present study was to investigate whether NALP3 inflammasome activation is involved in H2O2-mediated collagen synthesis, in addition to examining the possible cell signaling mechanisms underlying this effect.	Hydrogen Peroxide	107-111	NLR family, pyrin domain containing 3	Mus musculus	62-67
29393339-5	2018	H2O2-exposed fibroblasts exhibited activated NALP3 inflammasomes via increased NALP3, apoptosis-associated Speck-like protein and caspase-1 expression and the secretion of interleukin-1beta.	Hydrogen Peroxide	0-4	NLR family, pyrin domain containing 3	Mus musculus	45-50
29393339-5	2018	H2O2-exposed fibroblasts exhibited activated NALP3 inflammasomes via increased NALP3, apoptosis-associated Speck-like protein and caspase-1 expression and the secretion of interleukin-1beta.	Hydrogen Peroxide	0-4	NLR family, pyrin domain containing 3	Mus musculus	79-84
29393339-8	2018	Furthermore, the NALP3 inflammasome was found to be activated in bleomycin-induced pulmonary fibrosis in mice, and this activation was relieved by a nuclear factor (NF)-kappaB inhibitor.	Bleomycin	65-74	NLR family, pyrin domain containing 3	Mus musculus	17-22
29393339-9	2018	Taken together, these findings indicate that the NALP3 inflammasome is involved in H2O2-induced type I collagen synthesis, which is mediated by the NF-kappaB signaling pathway.	Hydrogen Peroxide	83-87	NLR family, pyrin domain containing 3	Mus musculus	49-54
29393339-10	2018	Additionally, the NALP3 inflammasome contributes to the development of bleomycin-induced pulmonary fibrosis.	Bleomycin	71-80	NLR family, pyrin domain containing 3	Mus musculus	18-23
29410031-7	2018	However, the observed reactions to aluminium adjuvants were independent of NALP3, caspase-1, and interleukin-1beta, but dependent on histamine.	Aluminum	35-44	NLR family, pyrin domain containing 3	Mus musculus	75-80
29274035-0	2018	MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson"s disease by targeting Nlrp3.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	44-48	NLR family, pyrin domain containing 3	Mus musculus	91-96
29274035-10	2018	Taken together, our study demonstrates that miR-30e ameliorates neuroinflammation in the MPTP model of PD by decreasing Nlrp3 inflammasome activity.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	89-93	NLR family, pyrin domain containing 3	Mus musculus	120-125
29438662-0	2018	Alendronate augments lipid A-induced IL-1beta release and Smad3/NLRP3/ASC-dependent cell death.	Alendronate	0-11	NLR family, pyrin domain containing 3	Mus musculus	64-69
29340626-0	2018	Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation.	sulforaphane	57-69	NLR family, pyrin domain containing 3	Mus musculus	15-20
29340626-1	2018	Objective: The aetiology of gout is closely linked to the deposition of monosodium uric acid (MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome.	monosodium uric acid	72-92	NLR family, pyrin domain containing 3	Mus musculus	198-203
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	115-120
29340626-1	2018	Objective: The aetiology of gout is closely linked to the deposition of monosodium uric acid (MSU) crystals and the consequent activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome.	msu	94-97	NLR family, pyrin domain containing 3	Mus musculus	198-203
29340626-5	2018	Results: Oral administration of SFN attenuated MSU crystal-induced swelling and neutrophil recruitment in a mouse foot acute gout model, correlating with the suppression of the NLRP3 inflammasome activation in foot tissues.	sulforaphane	32-35	NLR family, pyrin domain containing 3	Mus musculus	177-182
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	87-90	NLR family, pyrin domain containing 3	Mus musculus	51-56
29340626-6	2018	Consistently, oral administration of SFN blocked MSU-crystal-induced activation of the NLRP3 inflammasome in a mouse air pouch gout model.	sulforaphane	37-40	NLR family, pyrin domain containing 3	Mus musculus	87-92
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	87-90	NLR family, pyrin domain containing 3	Mus musculus	115-120
29340626-7	2018	SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly(dA:dT) in primary mouse macrophages, independent of the reactive oxygen species pathway.	Adenosine Triphosphate	70-92	NLR family, pyrin domain containing 3	Mus musculus	15-20
29340626-9	2018	Conclusion: Oral administration of SFN effectively alleviated acute gouty inflammation by suppression of the NLRP3 inflammasome.	sulforaphane	35-38	NLR family, pyrin domain containing 3	Mus musculus	109-114
29340626-7	2018	SFN suppressed NLRP3 inflammasome activation induced by MSU crystals, adenosine triphosphate and nigericin but not by poly(dA:dT) in primary mouse macrophages, independent of the reactive oxygen species pathway.	Nigericin	97-106	NLR family, pyrin domain containing 3	Mus musculus	15-20
28365974-0	2018	Diosmetin Alleviates Lipopolysaccharide-Induced Acute Lung Injury through Activating the Nrf2 Pathway and Inhibiting the NLRP3 Inflammasome.	diosmetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	121-126
29662437-9	2018	Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	83-88
29662437-9	2018	Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	154-159
29662437-9	2018	Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation.	Reactive Oxygen Species	79-82	NLR family, pyrin domain containing 3	Mus musculus	83-88
30134814-0	2018	Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity.	ethyl pyruvate	18-32	NLR family, pyrin domain containing 3	Mus musculus	38-43
30134814-7	2018	CONCLUSION: Ethyl pyruvate acts as a novel NLRP3 inflammasome inhibitor that preserves the integrity of mitochondria during inflammation.	ethyl pyruvate	12-26	NLR family, pyrin domain containing 3	Mus musculus	43-48
28365974-8	2018	Furthermore, diosmetin significantly increased the expression of Nrf2 along with its target gene HO-1 and blocked the activation of NLRP3 inflammasome in the lung tissues, which might be central to the protective effects of diosmetin.	diosmetin	13-22	NLR family, pyrin domain containing 3	Mus musculus	132-137
28365974-8	2018	Furthermore, diosmetin significantly increased the expression of Nrf2 along with its target gene HO-1 and blocked the activation of NLRP3 inflammasome in the lung tissues, which might be central to the protective effects of diosmetin.	diosmetin	224-233	NLR family, pyrin domain containing 3	Mus musculus	132-137
28365974-9	2018	Further supporting these results, in vitro experiments also showed that diosmetin activated Nrf2 and HO-1, as well as inhibited the NLRP3 inflammasome in both RAW264.7 and A549 cells.	diosmetin	72-81	NLR family, pyrin domain containing 3	Mus musculus	132-137
28365974-10	2018	The present study highlights the protective effects of diosmetin on LPS-induced ALI via activation of Nrf2 and inhibition of NLRP3 inflammasome, bringing up the hope of its application as a therapeutic drug towards LPS-induced ALI.	diosmetin	55-64	NLR family, pyrin domain containing 3	Mus musculus	125-130
29675433-0	2018	Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy.	ros	31-34	NLR family, pyrin domain containing 3	Mus musculus	35-40
29576052-0	2018	Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome.	norisoboldine	0-13	NLR family, pyrin domain containing 3	Mus musculus	133-138
29576052-8	2018	Both siAhR and alpha-naphthoflavone (alpha-NF) markedly diminished the inhibition of NOR on NLRP3 inflammasome activation.	alpha-naphthoflavone	15-35	NLR family, pyrin domain containing 3	Mus musculus	92-97
29241624-2	2018	Mechanistically, intrarenal calcium oxalate crystal deposition is thought to elicit inflammation, tubular injury and atrophy, involving the NLRP3 inflammasome.	Calcium Oxalate	28-43	NLR family, pyrin domain containing 3	Mus musculus	140-145
29241624-5	2018	NLRP3 inhibition using the beta-hydroxybutyrate precursor 1,3-butanediol protected such mice from nephrocalcinosis-related CKD.	3-Hydroxybutyric Acid	27-47	NLR family, pyrin domain containing 3	Mus musculus	0-5
29241624-5	2018	NLRP3 inhibition using the beta-hydroxybutyrate precursor 1,3-butanediol protected such mice from nephrocalcinosis-related CKD.	1,3-butylene glycol	58-72	NLR family, pyrin domain containing 3	Mus musculus	0-5
28357805-0	2018	Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis.	Peroxynitrous Acid	0-13	NLR family, pyrin domain containing 3	Mus musculus	28-33
29358279-5	2018	We demonstrate that NLRP3 inflammasome activation is blocked by removing copper from the active site of superoxide dismutase 1, recapitulating impaired inflammasome function in superoxide dismutase 1-deficient mice.	Copper	73-79	NLR family, pyrin domain containing 3	Mus musculus	20-25
28255908-3	2018	We first demonstrated increased formation and activation of NLRP3 inflammasome in TgCRND8 mice compared to non-transgenic littermate controls, which was inhibited by the treatment with JC-124.	jc-124	185-191	NLR family, pyrin domain containing 3	Mus musculus	60-65
28255908-6	2018	Overall, these data demonstrated beneficial effects of JC-124 as a specific NLRP3 inflammasome inhibitor in AD mouse model and supported the further development of NLRP3 inflammasome inhibitors as a viable option for AD therapeutics.	jc-124	55-61	NLR family, pyrin domain containing 3	Mus musculus	76-81
28255908-6	2018	Overall, these data demonstrated beneficial effects of JC-124 as a specific NLRP3 inflammasome inhibitor in AD mouse model and supported the further development of NLRP3 inflammasome inhibitors as a viable option for AD therapeutics.	jc-124	55-61	NLR family, pyrin domain containing 3	Mus musculus	164-169
29737062-0	2018	[Sodium Ferulate Attenuates Oxidative Stress Induced Inflammation via Suppressing NALP3 Inflammasome and p38 MAPK Signal Pathway].	ferulic acid	1-16	NLR family, pyrin domain containing 3	Mus musculus	82-87
29737062-5	2018	CONCLUSION: The mechanism of sodium ferulate attenuated oxidative stress induced inflammation may be through blunting p38 MAPK signal pathway,the expression of NALP3 inflammasome,Caspase-1 and the secretion of IL-1beta are reduced.	ferulic acid	29-44	NLR family, pyrin domain containing 3	Mus musculus	160-165
29675433-1	2018	Previous studies demonstrated that ROS-NLRP3 inflammasome signaling activation was involved in the pathogenesis of diabetic nephropathy (DN).	ros	35-38	NLR family, pyrin domain containing 3	Mus musculus	39-44
29675433-3	2018	Whether high glucose primes ROS-NLRP3 inflammasome signaling via STRs is unclear.	ros	28-31	NLR family, pyrin domain containing 3	Mus musculus	32-37
29675433-6	2018	Furthermore, lactisole significantly mitigated the production of intracellular ROS and reversed the high glucose-induced decrease of Ca2+ and the activation of NLRP3 inflammasome signaling in vitro (p &lt; 0.05).	lactisole	13-22	NLR family, pyrin domain containing 3	Mus musculus	160-165
29675433-6	2018	Furthermore, lactisole significantly mitigated the production of intracellular ROS and reversed the high glucose-induced decrease of Ca2+ and the activation of NLRP3 inflammasome signaling in vitro (p &lt; 0.05).	Glucose	105-112	NLR family, pyrin domain containing 3	Mus musculus	160-165
29675433-7	2018	These combined results support the hypothesis that STRs could be involved in the activation of ROS-NLRP3 inflammasome signaling in the pathogenesis of DN, suggesting that STRs may act as new therapeutic targets of DN.	ros	95-98	NLR family, pyrin domain containing 3	Mus musculus	99-104
29279328-1	2018	A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction.	Uric Acid	50-53	NLR family, pyrin domain containing 3	Mus musculus	78-83
28970254-0	2018	Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease.	Silybin	0-7	NLR family, pyrin domain containing 3	Mus musculus	17-22
28970254-5	2018	In addition, silybin inhibited the approach of calreticulin and translocase of outer membrane 20 (Tom20), prevented assembly of the NLRP3 inflammasome complex, and suppressed the accumulation of acetylated alpha-tubulin in the perinuclear region.	Silybin	13-20	NLR family, pyrin domain containing 3	Mus musculus	132-137
29279328-0	2018	Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.	Hydrogen Sulfide	0-16	NLR family, pyrin domain containing 3	Mus musculus	26-31
29279328-1	2018	A variety of stimuli, including monosodium urate (MSU) crystals, activate the NLRP3 inflammasome, and this activation involves several molecular mechanisms including xanthine oxidase (XO) up-regulation and mitochondrial dysfunction.	Uric Acid	32-48	NLR family, pyrin domain containing 3	Mus musculus	78-83
29636842-7	2018	Thus, BMSCs exert beneficial effects on inhibiting NLRP3 inflammasome activation in macrophages primarily via both enhancing mitophagy and decreasing mitochondrial ROS.	ros	164-167	NLR family, pyrin domain containing 3	Mus musculus	51-56
29055716-8	2018	Since ATP is a known activator of the NOD-like receptor protein 3 (NLRP3) inflammasome complex, a key mediator of neuroinflammation, we examined the effects of Peptide5 treatment on NLRP3 inflammasome expression.	Adenosine Triphosphate	6-9	NLR family, pyrin domain containing 3	Mus musculus	38-65
29055716-8	2018	Since ATP is a known activator of the NOD-like receptor protein 3 (NLRP3) inflammasome complex, a key mediator of neuroinflammation, we examined the effects of Peptide5 treatment on NLRP3 inflammasome expression.	Adenosine Triphosphate	6-9	NLR family, pyrin domain containing 3	Mus musculus	67-72
28970254-8	2018	The anti-inflammatory effect of silybin was blocked by SIRT2 silencing or by the SIRT2 inhibitor AGK2, as evidenced by NLRP3/ASC colocalization, AC-alpha-tubulin expression, and IL-1beta release.	Silybin	32-39	NLR family, pyrin domain containing 3	Mus musculus	119-124
28970254-0	2018	Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease.	NAD	57-61	NLR family, pyrin domain containing 3	Mus musculus	17-22
28970254-1	2018	Silybin is one of the effective, traditional Chinese medicines used as a hepatoprotective agent in nonalcoholic fatty liver disease (NAFLD) therapy worldwide, and the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been recognized as an important factor involved in NAFLD development.	Silybin	0-7	NLR family, pyrin domain containing 3	Mus musculus	219-224
28970254-3	2018	In our study, we found that silybin inhibited endoplasmic reticulum stress and NLRP3 inflammasome activation in the livers of HFD-fed mice and in cultured hepatocytes.	Silybin	28-35	NLR family, pyrin domain containing 3	Mus musculus	79-84
29434743-6	2018	In conclusion, the results of the present study suggested that AT-I exerts anti-depressant-like effects in a CUMS-induced model of depression in mice, the molecular mechanism of which is associated with the inhibition of NLRP3 inflammasome activation to decrease IL-1beta production.	cums	109-113	NLR family, pyrin domain containing 3	Mus musculus	221-226
29636853-7	2018	NaHS could improve renal function and kidney histopathological changes, attenuate LPS-induced inflammation and oxidative stress, and inhibit expressions of TLR4, NLRP3, and caspase-1.	sodium bisulfide	0-4	NLR family, pyrin domain containing 3	Mus musculus	162-167
29278702-5	2018	In mouse insulinoma cell line 6 (MIN6), hypoxia (1% O2) primes the NLRP3 inflammasome along with NF-kappaB signaling activation.	Oxygen	52-54	NLR family, pyrin domain containing 3	Mus musculus	67-72
29636853-8	2018	Our study demonstrated that endogenous H2S is involved in the pathogenesis of SA-AKI, and exogenous H2S exerts protective effects against LPS-induced AKI by inhibiting inflammation and oxidative stress via the TLR4/NLRP3 signaling pathway.	Hydrogen Sulfide	100-103	NLR family, pyrin domain containing 3	Mus musculus	215-220
29370073-3	2018	Studies with vitamin D3 plus phorbol ester transformed THP-1 macrophages demonstrated that functionalization, regardless of amount, corresponded with profoundly decreased NLRP3 inflammasome activation.	Cholecalciferol	13-23	NLR family, pyrin domain containing 3	Mus musculus	171-176
29370073-3	2018	Studies with vitamin D3 plus phorbol ester transformed THP-1 macrophages demonstrated that functionalization, regardless of amount, corresponded with profoundly decreased NLRP3 inflammasome activation.	Phorbol Esters	29-42	NLR family, pyrin domain containing 3	Mus musculus	171-176
29278702-8	2018	Finally, the role of the ROS-TXNIP axis in mediating the activation of the NLRP3 inflammasome and cell death was characterized by pretreating with the ROS scavenger N-acetylcysteine (NAC) and performing TXNIP knockdown experiments in MIN6.	Reactive Oxygen Species	25-28	NLR family, pyrin domain containing 3	Mus musculus	75-80
29278702-8	2018	Finally, the role of the ROS-TXNIP axis in mediating the activation of the NLRP3 inflammasome and cell death was characterized by pretreating with the ROS scavenger N-acetylcysteine (NAC) and performing TXNIP knockdown experiments in MIN6.	Reactive Oxygen Species	151-154	NLR family, pyrin domain containing 3	Mus musculus	75-80
29278702-8	2018	Finally, the role of the ROS-TXNIP axis in mediating the activation of the NLRP3 inflammasome and cell death was characterized by pretreating with the ROS scavenger N-acetylcysteine (NAC) and performing TXNIP knockdown experiments in MIN6.	Acetylcysteine	165-181	NLR family, pyrin domain containing 3	Mus musculus	75-80
29269298-0	2018	Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression.	Dexmedetomidine	0-15	NLR family, pyrin domain containing 3	Mus musculus	122-127
29278702-8	2018	Finally, the role of the ROS-TXNIP axis in mediating the activation of the NLRP3 inflammasome and cell death was characterized by pretreating with the ROS scavenger N-acetylcysteine (NAC) and performing TXNIP knockdown experiments in MIN6.	Acetylcysteine	183-186	NLR family, pyrin domain containing 3	Mus musculus	75-80
29278702-9	2018	Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS-TXNIP-NLRP3 axis in vitro.	Reactive Oxygen Species	157-160	NLR family, pyrin domain containing 3	Mus musculus	167-172
29269298-10	2018	In addition, dexmedetomidine at 20 mug/kg significantly down-regulated the expression of NLRP3, pro-IL-1beta, and IL-1beta in pancreatic tissue, but up-regulated the expression of NET in both mouse models.	Dexmedetomidine	13-28	NLR family, pyrin domain containing 3	Mus musculus	89-94
29507694-8	2018	Further supporting these results, we observed that pretreatment with the phosphatidylinositol 3-kinase inhibitor LY294002 abolished NGR1-mediated neuroprotective effects against oxidative stress and NLRP3 inflammasome activation in HG-treated HT22 hippocampal neurons.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	113-121	NLR family, pyrin domain containing 3	Mus musculus	199-204
29269298-11	2018	CONCLUSION: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.	Dexmedetomidine	12-27	NLR family, pyrin domain containing 3	Mus musculus	130-135
29507694-8	2018	Further supporting these results, we observed that pretreatment with the phosphatidylinositol 3-kinase inhibitor LY294002 abolished NGR1-mediated neuroprotective effects against oxidative stress and NLRP3 inflammasome activation in HG-treated HT22 hippocampal neurons.	Phosphatidylinositols	73-93	NLR family, pyrin domain containing 3	Mus musculus	199-204
29301581-2	2018	Previous study reported that the neurotransmitter dopamine inhibited NLRP3 inflammasome activation via dopamine D1 receptor (DRD1).	Dopamine	50-58	NLR family, pyrin domain containing 3	Mus musculus	69-74
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	14-25	NLR family, pyrin domain containing 3	Mus musculus	68-73
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	14-25	NLR family, pyrin domain containing 3	Mus musculus	251-256
29375379-10	2017	Intriguingly, scutellarin augmented PKA-specific phosphorylation of NLRP3 in LPS-primed macrophages, which was completely blocked by selective PKA inhibitor H89, suggesting that PKA signaling had been involved in the action of scutellarin to suppress NLRP3 inflammasome activation.	scutellarin	227-238	NLR family, pyrin domain containing 3	Mus musculus	68-73
29375379-11	2017	Supporting this, the inhibitory effect of scutellarin on NLRP3 inflammasome activation was completely counteracted by H89 or adenyl cyclase inhibitor MDL12330A.	scutellarin	42-53	NLR family, pyrin domain containing 3	Mus musculus	57-62
29375379-11	2017	Supporting this, the inhibitory effect of scutellarin on NLRP3 inflammasome activation was completely counteracted by H89 or adenyl cyclase inhibitor MDL12330A.	RMI 12330A	150-159	NLR family, pyrin domain containing 3	Mus musculus	57-62
29375379-12	2017	As NLRP3-dependent release of IL-1beta has a critical role in sepsis, the in vivo activity of scutellarin was assayed in a mouse model of bacterial sepsis, which was established by intraperitoneally injection of a lethal dose of viable Escherichia coli.	scutellarin	94-105	NLR family, pyrin domain containing 3	Mus musculus	3-8
29375379-15	2017	These data indicated that scutellarin suppressed NLRP3 inflammasome activation in macrophages by augmenting PKA signaling, highlighting its potential therapeutic application for treating NLRP3-related inflammatory diseases.	scutellarin	26-37	NLR family, pyrin domain containing 3	Mus musculus	49-54
29375379-15	2017	These data indicated that scutellarin suppressed NLRP3 inflammasome activation in macrophages by augmenting PKA signaling, highlighting its potential therapeutic application for treating NLRP3-related inflammatory diseases.	scutellarin	26-37	NLR family, pyrin domain containing 3	Mus musculus	187-192
29507526-0	2018	Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway.	formononetin	0-12	NLR family, pyrin domain containing 3	Mus musculus	99-104
29507526-0	2018	Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway.	Dextran Sulfate	40-62	NLR family, pyrin domain containing 3	Mus musculus	99-104
29507526-5	2018	In addition, the result showed that formononetin could reduce the NLRP3 pathway protein levels (NLRP3, ASC, IL-1beta) in vivo and vitro, and MCC950, the NLRP3 specific inhibitor, could alleviate the DSS-induced mice acute colitis.	formononetin	36-48	NLR family, pyrin domain containing 3	Mus musculus	66-71
29507526-5	2018	In addition, the result showed that formononetin could reduce the NLRP3 pathway protein levels (NLRP3, ASC, IL-1beta) in vivo and vitro, and MCC950, the NLRP3 specific inhibitor, could alleviate the DSS-induced mice acute colitis.	formononetin	36-48	NLR family, pyrin domain containing 3	Mus musculus	96-101
29507526-5	2018	In addition, the result showed that formononetin could reduce the NLRP3 pathway protein levels (NLRP3, ASC, IL-1beta) in vivo and vitro, and MCC950, the NLRP3 specific inhibitor, could alleviate the DSS-induced mice acute colitis.	formononetin	36-48	NLR family, pyrin domain containing 3	Mus musculus	96-101
29507526-6	2018	Furthermore, in the foundation of administrating MCC950 to inhibit activation of NLRP3 inflammasome, we failed to observe the protective effects of formononetin on acute colitis in mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	49-55	NLR family, pyrin domain containing 3	Mus musculus	81-86
29507526-7	2018	Collectively, our study for the first time confirmed the protective effects of formononetin on DSS-induced acute colitis via inhibiting the NLRP3 inflammasome pathway activation.	formononetin	79-91	NLR family, pyrin domain containing 3	Mus musculus	140-145
29375379-6	2017	In this study, we aimed to investigate whether scutellarin could affect the activation of NLRP3 inflammasome in macrophages.	scutellarin	47-58	NLR family, pyrin domain containing 3	Mus musculus	90-95
29375379-7	2017	The results showed that scutellarin dose-dependently reduced caspase-1 activation and decreased mature interleukin-1beta (IL-1beta) release in lipopolysaccharide (LPS)-primed macrophages upon ATP or nigericin stimulation, indicating that scutellarin inhibited NLRP3 inflammasome activation in macrophages.	scutellarin	24-35	NLR family, pyrin domain containing 3	Mus musculus	260-265
29354126-5	2017	In the present study, we found that procyanidin, a powerful antioxidation flavonoid, has a significant effect on ROS clearance on THP-1 macrophages after lipopolysaccharide (LPS) or LPS-combined adenosine triphosphate stimulation, thus downregulating MMP9 expression, suppressing NF-kappaB signaling, and interrupting the formation of the NLRP3 inflammasome.	procyanidin	36-47	NLR family, pyrin domain containing 3	Mus musculus	339-344
29354126-6	2017	Moreover, our in vivo data showed that procyanidin attenuated Dextran sulfate sodium-induced experimental colitis in a dose-dependent fashion by suppressing the expression of MMP9, NF-kappaB, and NLRP3 inflammasome signaling in colonic tissues in mice.	procyanidin	39-50	NLR family, pyrin domain containing 3	Mus musculus	196-201
29354126-6	2017	Moreover, our in vivo data showed that procyanidin attenuated Dextran sulfate sodium-induced experimental colitis in a dose-dependent fashion by suppressing the expression of MMP9, NF-kappaB, and NLRP3 inflammasome signaling in colonic tissues in mice.	Dextran Sulfate	62-84	NLR family, pyrin domain containing 3	Mus musculus	196-201
28986310-0	2018	The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation.	EMD 638683	19-28	NLR family, pyrin domain containing 3	Mus musculus	108-113
28986310-10	2018	Administration of the NLRP3 inflammasome inhibitor MCC950 indicated that EMD638683 attenuated Ang II-induced cardiac inflammation and fibrosis by inhibiting the NLRP3 inflammasome/IL-1beta secretion axis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	51-57	NLR family, pyrin domain containing 3	Mus musculus	22-27
28986310-10	2018	Administration of the NLRP3 inflammasome inhibitor MCC950 indicated that EMD638683 attenuated Ang II-induced cardiac inflammation and fibrosis by inhibiting the NLRP3 inflammasome/IL-1beta secretion axis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	51-57	NLR family, pyrin domain containing 3	Mus musculus	161-166
28986310-11	2018	These findings indicate that the SGK1 inhibitor EMD638683 can negatively regulate NLRP3 inflammasome activation, and may represent a promising approach to the treatment of hypertensive cardiac damage.	EMD 638683	48-57	NLR family, pyrin domain containing 3	Mus musculus	82-87
29111328-0	2018	3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates NLRP3 inflammasome-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglial cells.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	0-57	NLR family, pyrin domain containing 3	Mus musculus	69-74
28887870-8	2018	Isoliquiritigenin, an inhibitor of NALP3, decreased the rate of wound repair in WT mice.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	35-40
29111328-10	2018	Our results suggest that the anti-inflammatory functions of KHG26792 may be, at least in part, due to regulation of the P2X7R/NLRP3-mediated signaling pathway during microglial activation.	3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride	60-68	NLR family, pyrin domain containing 3	Mus musculus	126-131
29038005-0	2018	Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.	Prednisone	0-10	NLR family, pyrin domain containing 3	Mus musculus	62-67
29038005-0	2018	Prednisone alleviates demyelination through regulation of the NLRP3 inflammasome in a C57BL/6 mouse model of cuprizone-induced demyelination.	Cuprizone	109-118	NLR family, pyrin domain containing 3	Mus musculus	62-67
30359991-7	2018	Mechanistically, losartan, a nonpeptide Ang II receptor antagonist, decreased Ang II-induced NLRP3 inflammasome activation, lysosomal membrane permeability, lysosomal cathepsin B release, and macrophage digestion dysfunction.	Losartan	17-25	NLR family, pyrin domain containing 3	Mus musculus	93-98
29794447-19	2018	CONCLUSIONS: These data elucidated the effects of Nrf2 inhibition and NLRP3 inflammasome activation in LCA-induced liver injury.	Lithocholic Acid	103-106	NLR family, pyrin domain containing 3	Mus musculus	70-75
29794447-20	2018	The hepatoprotective activity of vardenafil in LCA-induced cholestatic damage may result from the drug"s ability to activate Nrf2 signaling and prevent the activation of NLRP3, which could suppress the inflammatory responses in hepatic tissue.	Vardenafil Dihydrochloride	33-43	NLR family, pyrin domain containing 3	Mus musculus	170-175
29794447-20	2018	The hepatoprotective activity of vardenafil in LCA-induced cholestatic damage may result from the drug"s ability to activate Nrf2 signaling and prevent the activation of NLRP3, which could suppress the inflammatory responses in hepatic tissue.	Lithocholic Acid	47-50	NLR family, pyrin domain containing 3	Mus musculus	170-175
28992480-9	2018	These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1beta and IL-18.	Zearalenone	109-112	NLR family, pyrin domain containing 3	Mus musculus	154-159
28992480-9	2018	These findings uncovered a possible mechanism of intestinal mucosal innate immunity in response to mycotoxin ZEA that ZEA could activate the ROS-mediated NLRP3 inflammasome and, in turn, contribute to the caspase-1-dependent activation of the inflammatory cytokines IL-1beta and IL-18.	Reactive Oxygen Species	141-144	NLR family, pyrin domain containing 3	Mus musculus	154-159
29794447-15	2018	Importantly, LCA induced the activation of NLRP3 inflammasome.	Lithocholic Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	43-48
29794447-16	2018	LCA increased the expression of NLRP3, ASC, caspase-1, and IL-1beta genes and proteins in hepatic tissue.	Lithocholic Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	32-37
28992480-0	2018	Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome.	Zearalenone	0-11	NLR family, pyrin domain containing 3	Mus musculus	69-74
28992480-0	2018	Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome.	Zearalenone	13-16	NLR family, pyrin domain containing 3	Mus musculus	69-74
30468127-6	2018	This effect was inhibited in cells treated with MCC950 as a common NLRP3 inhibitor, thereby implicating the role of NLRP3 inflammasome in epileptic neuronal apoptosis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	48-54	NLR family, pyrin domain containing 3	Mus musculus	67-72
30468127-6	2018	This effect was inhibited in cells treated with MCC950 as a common NLRP3 inhibitor, thereby implicating the role of NLRP3 inflammasome in epileptic neuronal apoptosis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	48-54	NLR family, pyrin domain containing 3	Mus musculus	116-121
30468127-8	2018	Compared with the wild type mice, neuronal loss induced by pentylenetetrazole was significantly inhibited in the NLRP3 KO mice.	Pentylenetetrazole	59-77	NLR family, pyrin domain containing 3	Mus musculus	113-118
28887870-10	2018	Treatment with adenosine triphosphate (ATP), a ligand of NALP3, upregulated the mRNA expression of pro-inflammatory cytokines at the wound site and accelerated wound healing in the WT mice.	Adenosine Triphosphate	15-37	NLR family, pyrin domain containing 3	Mus musculus	57-62
28887870-10	2018	Treatment with adenosine triphosphate (ATP), a ligand of NALP3, upregulated the mRNA expression of pro-inflammatory cytokines at the wound site and accelerated wound healing in the WT mice.	Adenosine Triphosphate	39-42	NLR family, pyrin domain containing 3	Mus musculus	57-62
28799242-3	2018	Here, we demonstrate that T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, inhibits NLRP3 inflammasome activation by damping basal and lipopolysaccharide-induced nuclear factor-kappaB-mediated up-regulation of NLRP3 and interleukin-1beta during the priming step and basal and ATP/lipopolysaccharide-induced ATP production, K+ efflux, and reactive oxygen species production during the activation step.	Adenosine Triphosphate	286-289	NLR family, pyrin domain containing 3	Mus musculus	94-99
29100037-0	2018	Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4/NFkappaB.	Dexmedetomidine	0-15	NLR family, pyrin domain containing 3	Mus musculus	97-102
28956063-0	2018	Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion.	Reactive Oxygen Species	26-29	NLR family, pyrin domain containing 3	Mus musculus	38-43
28956063-7	2018	Furthermore, the activation of NLRP3 inflammasome was sensitive to the reactive oxygen species (ROS) level and Nrf2 could decrease the production of ROS.	Reactive Oxygen Species	71-94	NLR family, pyrin domain containing 3	Mus musculus	31-36
28956063-7	2018	Furthermore, the activation of NLRP3 inflammasome was sensitive to the reactive oxygen species (ROS) level and Nrf2 could decrease the production of ROS.	Reactive Oxygen Species	96-99	NLR family, pyrin domain containing 3	Mus musculus	31-36
28956063-7	2018	Furthermore, the activation of NLRP3 inflammasome was sensitive to the reactive oxygen species (ROS) level and Nrf2 could decrease the production of ROS.	Reactive Oxygen Species	149-152	NLR family, pyrin domain containing 3	Mus musculus	31-36
28956063-9	2018	CONCLUSION: We elucidated an inhibitory regulation of Nrf2/ARE pathway on ROS-induced NLRP3 inflammasome activation in BV2 microglial cells after OGDR exposure.	Reactive Oxygen Species	74-77	NLR family, pyrin domain containing 3	Mus musculus	86-91
28799242-3	2018	Here, we demonstrate that T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, inhibits NLRP3 inflammasome activation by damping basal and lipopolysaccharide-induced nuclear factor-kappaB-mediated up-regulation of NLRP3 and interleukin-1beta during the priming step and basal and ATP/lipopolysaccharide-induced ATP production, K+ efflux, and reactive oxygen species production during the activation step.	Adenosine Triphosphate	317-320	NLR family, pyrin domain containing 3	Mus musculus	94-99
28799242-3	2018	Here, we demonstrate that T cell Ig mucin-3 (Tim-3), an immune checkpoint inhibitor, inhibits NLRP3 inflammasome activation by damping basal and lipopolysaccharide-induced nuclear factor-kappaB-mediated up-regulation of NLRP3 and interleukin-1beta during the priming step and basal and ATP/lipopolysaccharide-induced ATP production, K+ efflux, and reactive oxygen species production during the activation step.	Reactive Oxygen Species	348-371	NLR family, pyrin domain containing 3	Mus musculus	94-99
29334279-1	2018	In an effort to improve the adjuvanticity of insoluble aluminium salts, we discovered that the adjuvant activity of aluminium salt nanoparticles is significantly stronger than aluminium salt microparticles, likely related to nanoparticle"s stronger ability to directly activate NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome as the nanoparticles are more efficiently taken up by phagocytic cells.	aluminium salt	116-130	NLR family, pyrin domain containing 3	Mus musculus	278-325
28799242-4	2018	Residues Y256/Y263 in the C-terminal region of Tim-3 are required for these inhibitory effects on the NLRP3 inflammasome.	y256	9-13	NLR family, pyrin domain containing 3	Mus musculus	102-107
28799242-4	2018	Residues Y256/Y263 in the C-terminal region of Tim-3 are required for these inhibitory effects on the NLRP3 inflammasome.	y263	14-18	NLR family, pyrin domain containing 3	Mus musculus	102-107
29202301-2	2018	beta-Glucan-induced dectin-1 signalling activates the NLRP3 inflammasome, which in turn rapidly produces IL-1beta, a master regulator of inflammation.	beta-Glucans	0-11	NLR family, pyrin domain containing 3	Mus musculus	54-59
29202301-5	2018	Furthermore, SYK inhibition markedly decreased beta-glucan-induced IL-1beta expression, suggesting that SYK is indispensable for NLRP3 inflammasome activation.	beta-Glucans	47-58	NLR family, pyrin domain containing 3	Mus musculus	129-134
29854992-0	2018	The Immunomodulatory Properties of 2-Hydroxyethyl Methacrylate are Mediated by the NLRP3 Inflammasome.	hydroxyethyl methacrylate	35-62	NLR family, pyrin domain containing 3	Mus musculus	83-88
29334279-1	2018	In an effort to improve the adjuvanticity of insoluble aluminium salts, we discovered that the adjuvant activity of aluminium salt nanoparticles is significantly stronger than aluminium salt microparticles, likely related to nanoparticle"s stronger ability to directly activate NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome as the nanoparticles are more efficiently taken up by phagocytic cells.	aluminium salt	116-130	NLR family, pyrin domain containing 3	Mus musculus	327-332
29180292-3	2018	We found that ESAT-6 induced caspase-1 activation and inflammasome priming in mouse RPE cells, substantially more in wild-type than in Tlr2/3/4/7/9-/-, Myd88-/- or Nlrp3-/- RPE cells.	esat-6	14-20	NLR family, pyrin domain containing 3	Mus musculus	164-169
29393276-10	2018	Isoliquiritigenin prevents NSAID-induced small intestinal damage by inhibiting NLRP3 inflammasome activation.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	79-84
29061758-7	2018	Furthermore, by using the murine macrophage line RAW 264.7, we found that PZQ could inhibit the formation of the NLRP3 inflammasome and attenuate phagocytic activity in M1 macrophages.	Praziquantel	74-77	NLR family, pyrin domain containing 3	Mus musculus	113-118
28963039-6	2018	We speculated that ketamine triggered the formation of NLRP3 and caspase-1 complex and its translocation to the mitochondria.	Ketamine	19-27	NLR family, pyrin domain containing 3	Mus musculus	55-60
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	Palmitic Acid	44-46	NLR family, pyrin domain containing 3	Mus musculus	83-88
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	Palmitic Acid	44-46	NLR family, pyrin domain containing 3	Mus musculus	190-195
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	baicalin	121-123	NLR family, pyrin domain containing 3	Mus musculus	83-88
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	baicalin	121-123	NLR family, pyrin domain containing 3	Mus musculus	190-195
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	ursodoxicoltaurine	128-133	NLR family, pyrin domain containing 3	Mus musculus	83-88
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	ursodoxicoltaurine	128-133	NLR family, pyrin domain containing 3	Mus musculus	190-195
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	baicalin	151-153	NLR family, pyrin domain containing 3	Mus musculus	83-88
29031535-7	2017	Furthermore, western blotting revealed that PA-challenged expressions of TXNIP and NLRP3 were dramatically suppressed by BA and TUDCA, suggesting that BA inhibited ER stress through a TXNIP/NLRP3 pathway.	baicalin	151-153	NLR family, pyrin domain containing 3	Mus musculus	190-195
29031535-8	2017	Overall, our results indicate that BA alleviates PA-induced cytotoxicity in AML-12 cells via suppression of ER stress and TXNIP/NLRP3 inflammasome activation.	baicalin	35-37	NLR family, pyrin domain containing 3	Mus musculus	128-133
29031535-8	2017	Overall, our results indicate that BA alleviates PA-induced cytotoxicity in AML-12 cells via suppression of ER stress and TXNIP/NLRP3 inflammasome activation.	Palmitic Acid	49-51	NLR family, pyrin domain containing 3	Mus musculus	128-133
29212744-3	2018	MCC950 is a potent, selective, small-molecule NLRP3 inhibitor that blocks NLRP3 activation at nanomolar concentrations.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	46-51
29212744-3	2018	MCC950 is a potent, selective, small-molecule NLRP3 inhibitor that blocks NLRP3 activation at nanomolar concentrations.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	74-79
29262843-9	2017	These data indicate that tenuigenin inhibits the activation of NLRP3 inflammasome via downregulating ROS.	Reactive Oxygen Species	101-104	NLR family, pyrin domain containing 3	Mus musculus	63-68
29259897-0	2017	Pioglitazone ameliorates retinal ischemia/reperfusion injury via suppressing NLRP3 inflammasome activities.	Pioglitazone	0-12	NLR family, pyrin domain containing 3	Mus musculus	77-82
29061706-2	2018	We recently reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1beta (IL-1beta) secretion in macrophages.	Adenosine Diphosphate	51-54	NLR family, pyrin domain containing 3	Mus musculus	185-190
29146293-5	2017	Andrographolide suppressed overexpression of microglial MIP-1alpha, P2X7 receptor and its downstream signaling mediators including-inflammasome NLRP3, caspase1 and mature IL-1beta.	andrographolide	0-15	NLR family, pyrin domain containing 3	Mus musculus	144-149
29312513-5	2017	In addition, NLRP3, as a sensor protein of ROS, may contribute to inflammasome assembly and subsequent inflammation in the cochleae.	Reactive Oxygen Species	43-46	NLR family, pyrin domain containing 3	Mus musculus	13-18
29311802-9	2017	Inhibition of Caspase-11 expression with either wedelolactone or siRNAs reduced the expression of inflammasome NLRP3 and pro-inflammatory cytokines.	wedelolactone	48-61	NLR family, pyrin domain containing 3	Mus musculus	111-116
28837807-0	2017	WITHDRAWN: Schisandrin B suppresses NLRP3 inflammasome activation to alleviate myocardial ischemia reperfusion injury via maintaining mitochondrial autophagy.	schizandrin B	11-24	NLR family, pyrin domain containing 3	Mus musculus	36-41
28918467-9	2017	Moreover, anisodamine treatment reduced expression of ER stress markers IRE-1alpha, CHOP, and ATF4, TXNIP and NLRP3, as well as ACS, Caspase-1, IL-1alpha, IL-1beta, and IL-18, showing moderate protective effect on the changes of above factors comparing with TXNIP or NLRP3 knock down.	anisodamine	10-21	NLR family, pyrin domain containing 3	Mus musculus	110-115
28918467-9	2017	Moreover, anisodamine treatment reduced expression of ER stress markers IRE-1alpha, CHOP, and ATF4, TXNIP and NLRP3, as well as ACS, Caspase-1, IL-1alpha, IL-1beta, and IL-18, showing moderate protective effect on the changes of above factors comparing with TXNIP or NLRP3 knock down.	anisodamine	10-21	NLR family, pyrin domain containing 3	Mus musculus	267-272
28918467-0	2017	Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury.	anisodamine	0-11	NLR family, pyrin domain containing 3	Mus musculus	67-72
28918467-10	2017	This study declared that anisodamine showed protective effect on RIAKI model may by inhibiting ER stress associated TXNIP/NLRP3 inflammasome.	anisodamine	25-36	NLR family, pyrin domain containing 3	Mus musculus	122-127
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Asbestos	0-8	NLR family, pyrin domain containing 3	Mus musculus	207-234
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	43-65	NLR family, pyrin domain containing 3	Mus musculus	207-234
29285164-0	2017	Resveratrol alleviates Staphylococcus aureus pneumonia by inhibition of the NLRP3 inflammasome.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	76-81
29285164-5	2017	In addition, reverse-transcription quantitative polymerase chain reaction and western blot assays showed that resveratrol markedly decreased the mRNA and protein expression of nucleotide-binding domain and leucine-rich repeat containing gene family pyrin domain containing 3 protein (NLRP3), apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain and caspase-1.	Resveratrol	110-121	NLR family, pyrin domain containing 3	Mus musculus	284-289
29285164-6	2017	These results demonstrated that resveratrol significantly alleviates S. aureus pneumonia in mice, the possible underlying mechanism of which is associated with the inhibition of the NLRP3 inflammasome.	Resveratrol	32-43	NLR family, pyrin domain containing 3	Mus musculus	182-187
28730512-0	2017	NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid.	Palmitic Acid	115-128	NLR family, pyrin domain containing 3	Mus musculus	0-5
28730512-9	2017	We found that KCs and NLRP3 play pro-inflammatory roles in the progression of NASH, probably through secretions of IL-1beta and IL-18 by KCs induced by PA.	Palmitic Acid	152-154	NLR family, pyrin domain containing 3	Mus musculus	22-27
28730512-10	2017	PA could act as a kind of damage-associated molecular patterns to elevate the messenger RNA and protein expression levels of NLRP3, ASC, and caspase-1 in KCs from WT mice.	Palmitic Acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	125-130
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	43-65	NLR family, pyrin domain containing 3	Mus musculus	236-241
28730512-11	2017	In the contrast, NLRP3 deletion could inhibit the NLRP3 inflammasome upregulation and activation in KCs induced by PA.	Palmitic Acid	115-117	NLR family, pyrin domain containing 3	Mus musculus	17-22
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	67-70	NLR family, pyrin domain containing 3	Mus musculus	207-234
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Asbestos	0-8	NLR family, pyrin domain containing 3	Mus musculus	236-241
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Adenosine Triphosphate	67-70	NLR family, pyrin domain containing 3	Mus musculus	236-241
28730512-11	2017	In the contrast, NLRP3 deletion could inhibit the NLRP3 inflammasome upregulation and activation in KCs induced by PA.	Palmitic Acid	115-117	NLR family, pyrin domain containing 3	Mus musculus	50-55
28730512-13	2017	In conclusion, our novel findings demonstrate that NLRP3 plays a pivotal role in NASH development and pro-inflammatory cytokines IL-1beta and IL-18 secretion induced by PA stimulation, and NLRP3 might be an effective potential target for the treatment of liver inflammatory diseases associated with NLRP3 inflammasome activation.	Palmitic Acid	169-171	NLR family, pyrin domain containing 3	Mus musculus	51-56
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Silicon Dioxide	13-19	NLR family, pyrin domain containing 3	Mus musculus	207-234
28766178-1	2017	Asbestos and silica (exogenous danger) and adenosine triphosphate (ATP, endogenous danger-signaling molecule) synergistically increase IL-1beta release from endotoxin-primed macrophage, which is mediated by NOD-like receptor protein 3 (NLRP3) inflammasome.	Silicon Dioxide	13-19	NLR family, pyrin domain containing 3	Mus musculus	236-241
27957680-7	2017	Expression of NLRP3 inflammasome proteins and levels of activated caspase 1 and mature interleukin 1 beta were significantly reduced in SOD1(G93A) mice supplemented with E2.	Estradiol	170-172	NLR family, pyrin domain containing 3	Mus musculus	14-19
28855315-9	2017	Eplerenone suppressed the expression of the inflammasome components, Nlrp3 and Caspase1, in the eWAT and liver.	Eplerenone	0-10	NLR family, pyrin domain containing 3	Mus musculus	69-74
28855315-11	2017	These results indicate that eplerenone inhibited both the priming and triggering signals that promote NLRP3-inflammasome activation.	Eplerenone	28-38	NLR family, pyrin domain containing 3	Mus musculus	102-107
29031144-10	2017	These results demonstrate that SEN plays an important role in treatment CUMS-induced depression in mice, possibly via suppression of pathway activation associated with NLRP3 inflammasome.	cums	72-76	NLR family, pyrin domain containing 3	Mus musculus	168-173
28466394-3	2017	Thus, in the present study, we investigated the hypothesis that NLRP3 inflammasome activation is linked to rotenone (ROT)-induced microglial activation which is dependent upon a priming stimulus by a pathogen-associated molecular pattern (PAMP) or damage associated molecular pattern (DAMP), respectively.	Rotenone	107-115	NLR family, pyrin domain containing 3	Mus musculus	64-69
28466394-3	2017	Thus, in the present study, we investigated the hypothesis that NLRP3 inflammasome activation is linked to rotenone (ROT)-induced microglial activation which is dependent upon a priming stimulus by a pathogen-associated molecular pattern (PAMP) or damage associated molecular pattern (DAMP), respectively.	Rotenone	117-120	NLR family, pyrin domain containing 3	Mus musculus	64-69
28466394-8	2017	In LPS treated mice, dasatinib attenuated NLRP3 inflammasome activation, c-Abl and PKCdelta activation; and sickness behavior.	Dasatinib	21-30	NLR family, pyrin domain containing 3	Mus musculus	42-47
28942141-0	2017	Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages.	Carbon Monoxide	0-15	NLR family, pyrin domain containing 3	Mus musculus	47-52
29178967-0	2017	Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation.	Morphine	52-60	NLR family, pyrin domain containing 3	Mus musculus	96-101
29178967-2	2017	Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance.	Morphine	19-27	NLR family, pyrin domain containing 3	Mus musculus	95-122
29178967-2	2017	Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance.	Morphine	19-27	NLR family, pyrin domain containing 3	Mus musculus	124-129
29178967-2	2017	Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance.	Morphine	162-170	NLR family, pyrin domain containing 3	Mus musculus	95-122
29178967-2	2017	Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance.	Morphine	162-170	NLR family, pyrin domain containing 3	Mus musculus	124-129
29178967-5	2017	Glibenclamide, a classic KATP channel blocker, can improve neuroinflammation by inhibiting the activation of NLRP3 inflammasome.	Glyburide	0-13	NLR family, pyrin domain containing 3	Mus musculus	109-114
29178967-6	2017	Our present study investigated the effect and possible mechanism of glibenclamide in improving morphine tolerance via its specific inhibition on the release of HSP70 and activation of NLRP3 inflammasome induced by morphine.	Glyburide	68-81	NLR family, pyrin domain containing 3	Mus musculus	184-189
29178967-6	2017	Our present study investigated the effect and possible mechanism of glibenclamide in improving morphine tolerance via its specific inhibition on the release of HSP70 and activation of NLRP3 inflammasome induced by morphine.	Morphine	214-222	NLR family, pyrin domain containing 3	Mus musculus	184-189
29178967-16	2017	Glibenclamide as a classic KATP channel blocker markedly inhibited the release of HSP70 induced by morphine and suppressed HSP70-TLR4-NLRP3 inflammasome-mediated neuroinflammation, which consequently attenuated morphine tolerance.	Glyburide	0-13	NLR family, pyrin domain containing 3	Mus musculus	134-139
29178967-17	2017	CONCLUSIONS: Our study indicated that morphine-induced extracellular HSP70 was an alternative way for the activation of TLR4-NLRP3 in analgesic tolerance.	Morphine	38-46	NLR family, pyrin domain containing 3	Mus musculus	125-130
29024091-9	2017	Furthermore, CD suppressed the LPS-induced NLRP3, Caspase-1, and IL-1beta mRNA expression in lung, as well as the expression of NLRP3 and Caspase-1 (p20) protein.	Cadmium	13-15	NLR family, pyrin domain containing 3	Mus musculus	43-48
29024091-9	2017	Furthermore, CD suppressed the LPS-induced NLRP3, Caspase-1, and IL-1beta mRNA expression in lung, as well as the expression of NLRP3 and Caspase-1 (p20) protein.	Cadmium	13-15	NLR family, pyrin domain containing 3	Mus musculus	128-133
29024091-10	2017	CD may have protective effects in endotoxin-poisoned mice via inhibiting the activation of NLRP3 inflammasome, and can be considered as a potential therapeutic candidate for diseases involved in endotoxin poisoning such as sepsis.	Cadmium	0-2	NLR family, pyrin domain containing 3	Mus musculus	91-96
29180692-0	2017	Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice.	baicalein	0-9	NLR family, pyrin domain containing 3	Mus musculus	91-96
29180692-0	2017	Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice.	Trinitrobenzenesulfonic Acid	22-26	NLR family, pyrin domain containing 3	Mus musculus	91-96
29160418-13	2017	These data demonstrated an association between serum vitamin D levels and outcomes of obese asthma, and indicated that NLRP3 inflammasome may play a role in this disorder.	Vitamin D	53-62	NLR family, pyrin domain containing 3	Mus musculus	119-124
29141025-12	2017	Collectively, our results demonstrate that the anti-inflammatory activity of EO and 1,8-cineole is modulated via selective downregulation of the PRR pathways, including PRR receptors (TREM-1 and NLRP3) and common downstream signaling cascade partners (NF-kappaB, MAPKs, MKP-1).	Eucalyptol	84-95	NLR family, pyrin domain containing 3	Mus musculus	195-200
29141025-13	2017	To our knowledge, this is the first report on the modulatory role of TREM-1 and NLRP3 inflammasome pathways and the MAPK negative regulator MKP-1 in context of the anti-inflammatory potential of EO and its constituent 1,8-cineole.	Eucalyptol	218-229	NLR family, pyrin domain containing 3	Mus musculus	80-85
29118366-5	2017	In particular, the NLRP3 alkylation by BOT-4-one led to an impaired ATPase activity of NLRP3, thereby obstructing the assembly of the NLRP3 inflammasome.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	39-48	NLR family, pyrin domain containing 3	Mus musculus	87-92
29163554-0	2017	Isoliquiritigenin Activates Nuclear Factor Erythroid-2 Related Factor 2 to Suppress the NOD-Like Receptor Protein 3 Inflammasome and Inhibits the NF-kappaB Pathway in Macrophages and in Acute Lung Injury.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	88-115
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	0-17	NLR family, pyrin domain containing 3	Mus musculus	150-155
29163554-3	2017	Isoliquiritigenin (ISL), a flavonoid from the liquorice compound, is suggested to be a regulator of the above pathways, but the mechanisms of how the NLRP3/NF-kappaB pathway interacts with Nrf2 and its protective effects in ALI remain unknown.	isoliquiritigenin	19-22	NLR family, pyrin domain containing 3	Mus musculus	150-155
29118366-6	2017	Additionally, we found that NLRP3 alkylators, including BOT-4-one, enhance the ubiquitination level of NLRP3, which might also contribute to the inhibition of NLRP3 inflammasome activation.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	56-65	NLR family, pyrin domain containing 3	Mus musculus	28-33
29118366-6	2017	Additionally, we found that NLRP3 alkylators, including BOT-4-one, enhance the ubiquitination level of NLRP3, which might also contribute to the inhibition of NLRP3 inflammasome activation.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	56-65	NLR family, pyrin domain containing 3	Mus musculus	103-108
29118366-6	2017	Additionally, we found that NLRP3 alkylators, including BOT-4-one, enhance the ubiquitination level of NLRP3, which might also contribute to the inhibition of NLRP3 inflammasome activation.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	56-65	NLR family, pyrin domain containing 3	Mus musculus	103-108
29118366-7	2017	Finally, BOT-4-one appeared to be superior to other known NLRP3 alkylators in inhibiting the functionality of the NLRP3 inflammasome and its resulting anti-inflammatory activity was confirmed in vivo using a monosodium urate-induced peritonitis mouse model.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	9-18	NLR family, pyrin domain containing 3	Mus musculus	58-63
29118366-0	2017	BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	0-9	NLR family, pyrin domain containing 3	Mus musculus	21-26
29084176-4	2017	Our results showed that SiO2 plain NPs induced NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome activation, increasing interleukin (IL)-1beta release in vitro, and, to a lesser extent, in vivo.	Silicon Dioxide	24-28	NLR family, pyrin domain containing 3	Mus musculus	47-94
29118366-0	2017	BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	0-9	NLR family, pyrin domain containing 3	Mus musculus	52-57
29118366-3	2017	Here, we demonstrate NLRP3 inflammasome-specific action of a benzoxathiole derivative, BOT-4-one.	benzoxathiole	61-74	NLR family, pyrin domain containing 3	Mus musculus	21-26
29118366-3	2017	Here, we demonstrate NLRP3 inflammasome-specific action of a benzoxathiole derivative, BOT-4-one.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	87-96	NLR family, pyrin domain containing 3	Mus musculus	21-26
29118366-4	2017	BOT-4-one exhibited an inhibition of NLRP3 inflammasome activation, which was attributable to its alkylating capability to NLRP3.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	0-9	NLR family, pyrin domain containing 3	Mus musculus	37-42
29118366-4	2017	BOT-4-one exhibited an inhibition of NLRP3 inflammasome activation, which was attributable to its alkylating capability to NLRP3.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	0-9	NLR family, pyrin domain containing 3	Mus musculus	123-128
29118366-5	2017	In particular, the NLRP3 alkylation by BOT-4-one led to an impaired ATPase activity of NLRP3, thereby obstructing the assembly of the NLRP3 inflammasome.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	39-48	NLR family, pyrin domain containing 3	Mus musculus	19-24
29118366-5	2017	In particular, the NLRP3 alkylation by BOT-4-one led to an impaired ATPase activity of NLRP3, thereby obstructing the assembly of the NLRP3 inflammasome.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	39-48	NLR family, pyrin domain containing 3	Mus musculus	87-92
29021150-5	2017	Importantly, treatment with CY-09 shows remarkable therapeutic effects on mouse models of cryopyrin-associated autoinflammatory syndrome (CAPS) and type 2 diabetes.	CY5.5 cyanine dye	28-33	NLR family, pyrin domain containing 3	Mus musculus	90-99
28962083-0	2017	Cordycepin inhibits LPS-induced inflammatory responses by modulating NOD-Like Receptor Protein 3 inflammasome activation.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	69-96
28941191-6	2017	PNU282987 also significantly inhibited the activation of NLRP3 inflammasome and thus decreased the production of IL-1beta and IL-18 both in lipopolysaccharide (LPS)/ATP-stimulated BV2 microglia in vitro and spinal cord from EAE mice in vivo, while inverse effects were observed in alpha7nAChR knockout mice.	PNU-282987	0-9	NLR family, pyrin domain containing 3	Mus musculus	57-62
28941191-6	2017	PNU282987 also significantly inhibited the activation of NLRP3 inflammasome and thus decreased the production of IL-1beta and IL-18 both in lipopolysaccharide (LPS)/ATP-stimulated BV2 microglia in vitro and spinal cord from EAE mice in vivo, while inverse effects were observed in alpha7nAChR knockout mice.	Adenosine Triphosphate	165-168	NLR family, pyrin domain containing 3	Mus musculus	57-62
28941191-7	2017	Furthermore, overexpression of beta-arrestin-1 attenuated the inhibitory effect of PNU282987 on NLRP3 inflammasome activation in LPS/ATP-stimulated BV2 microglia.	PNU-282987	83-92	NLR family, pyrin domain containing 3	Mus musculus	96-101
28941191-7	2017	Furthermore, overexpression of beta-arrestin-1 attenuated the inhibitory effect of PNU282987 on NLRP3 inflammasome activation in LPS/ATP-stimulated BV2 microglia.	Adenosine Triphosphate	133-136	NLR family, pyrin domain containing 3	Mus musculus	96-101
28941191-8	2017	PNU282987 inhibited the interaction between beta-arrestin-1 and NLRP3 protein in vitro.	PNU-282987	0-9	NLR family, pyrin domain containing 3	Mus musculus	64-69
28938188-8	2017	The increases were inhibited by hemin and the inhibition of hemin on ROS production and NLRP3 inflammasome activation were blocked by ZnPP.	zinc protoporphyrin	134-138	NLR family, pyrin domain containing 3	Mus musculus	88-93
28905319-8	2017	Consistently, the expression of chemokine-like receptor 1 (CMKLR1) and nucleotide oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) was significantly lower in the KCs and mice treated with wortmannin than those treated with IGF-1.	Wortmannin	223-233	NLR family, pyrin domain containing 3	Mus musculus	159-164
28930866-8	2017	CONCLUSIONS: P2X7R antagonist OxATP and BBG significantly decreased pancreatic chronic inflammation and fibrosis in a mouse CP model and suggested that blockade of P2X7R-NLRP3 inflammasome signaling pathway may represent a novel therapeutic strategy for CP and its fibrotic process.	2',3'-dialdehyde ATP	30-35	NLR family, pyrin domain containing 3	Mus musculus	170-175
29118366-7	2017	Finally, BOT-4-one appeared to be superior to other known NLRP3 alkylators in inhibiting the functionality of the NLRP3 inflammasome and its resulting anti-inflammatory activity was confirmed in vivo using a monosodium urate-induced peritonitis mouse model.	2-cyclohexylimino-6-methyl-6,7-dihydro-5H-benzo(1,3)oxathiol-4-one	9-18	NLR family, pyrin domain containing 3	Mus musculus	114-119
29118366-7	2017	Finally, BOT-4-one appeared to be superior to other known NLRP3 alkylators in inhibiting the functionality of the NLRP3 inflammasome and its resulting anti-inflammatory activity was confirmed in vivo using a monosodium urate-induced peritonitis mouse model.	Uric Acid	219-224	NLR family, pyrin domain containing 3	Mus musculus	114-119
28867183-0	2017	Indomethacin inhabits the NLRP3 inflammasome pathway and protects severe acute pancreatitis in mice.	Indomethacin	0-12	NLR family, pyrin domain containing 3	Mus musculus	26-31
28867183-7	2017	Taken together, our data showed that Indo could protect pancreatic acinar cell from injury by inhabiting NLRP3 pathway and decreased the severity of SAP accordingly.	Indomethacin	37-41	NLR family, pyrin domain containing 3	Mus musculus	105-110
29084550-10	2017	Furthermore, antidiabetic drug glyburide, an inhibitor of the NLRP3 inflammasome, was discovered to be effective in preventing the experimental comorbidity.	Glyburide	31-40	NLR family, pyrin domain containing 3	Mus musculus	62-67
29084176-4	2017	Our results showed that SiO2 plain NPs induced NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome activation, increasing interleukin (IL)-1beta release in vitro, and, to a lesser extent, in vivo.	Silicon Dioxide	24-28	NLR family, pyrin domain containing 3	Mus musculus	96-101
29228654-14	2017	Dietary A438079 showed modest inhibition of P2X7R, NLRP3, and IL-33, whereas AZ10606120 had no effects.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	8-15	NLR family, pyrin domain containing 3	Mus musculus	51-56
29163487-4	2017	The formation of ASC specks, a critical marker of NLRP3 inflammasome assembly, was robustly inhibited by baicalin in the macrophages upon ATP or nigericin stimulation.	baicalin	105-113	NLR family, pyrin domain containing 3	Mus musculus	50-55
29163487-4	2017	The formation of ASC specks, a critical marker of NLRP3 inflammasome assembly, was robustly inhibited by baicalin in the macrophages upon ATP or nigericin stimulation.	Adenosine Triphosphate	138-141	NLR family, pyrin domain containing 3	Mus musculus	50-55
29163487-4	2017	The formation of ASC specks, a critical marker of NLRP3 inflammasome assembly, was robustly inhibited by baicalin in the macrophages upon ATP or nigericin stimulation.	Nigericin	145-154	NLR family, pyrin domain containing 3	Mus musculus	50-55
29163487-7	2017	Of note, the PKA inhibitor H89 could block baicalin-induced NLRP3 phosphorylation on PKA-specific sites, further supporting PKA"s role in this process.	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	27-30	NLR family, pyrin domain containing 3	Mus musculus	60-65
29163487-7	2017	Of note, the PKA inhibitor H89 could block baicalin-induced NLRP3 phosphorylation on PKA-specific sites, further supporting PKA"s role in this process.	baicalin	43-51	NLR family, pyrin domain containing 3	Mus musculus	60-65
29163487-10	2017	Altogether, our results revealed that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling, highlighting its therapeutic potential for the treatment of NLRP3-related inflammatory diseases.	baicalin	38-46	NLR family, pyrin domain containing 3	Mus musculus	57-62
29163487-10	2017	Altogether, our results revealed that baicalin inhibited NLRP3 inflammasome activation at least partly through augmenting PKA signaling, highlighting its therapeutic potential for the treatment of NLRP3-related inflammatory diseases.	baicalin	38-46	NLR family, pyrin domain containing 3	Mus musculus	197-202
29163487-3	2017	Here, we showed that baicalin treatment dose-dependently inhibited adenosine triphosphate (ATP) or nigericin-induced NLRP3 inflammasome activation, as revealed by the decreased release of mature interleukin (IL)-1beta, active caspase-1p10, and high-mobility group box-1 protein from lipopolysaccharide (LPS)-primed bone marrow-derived macrophages.	baicalin	21-29	NLR family, pyrin domain containing 3	Mus musculus	117-122
29163487-3	2017	Here, we showed that baicalin treatment dose-dependently inhibited adenosine triphosphate (ATP) or nigericin-induced NLRP3 inflammasome activation, as revealed by the decreased release of mature interleukin (IL)-1beta, active caspase-1p10, and high-mobility group box-1 protein from lipopolysaccharide (LPS)-primed bone marrow-derived macrophages.	Nigericin	99-108	NLR family, pyrin domain containing 3	Mus musculus	117-122
29066896-3	2017	Aminated gamma-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1beta.	poly(gamma-glutamic acid)	9-18	NLR family, pyrin domain containing 3	Mus musculus	48-53
28653829-0	2017	Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.	hydroxyl-sulfonamide	38-58	NLR family, pyrin domain containing 3	Mus musculus	150-155
28653829-0	2017	Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis.	5-chloro-n-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide	69-137	NLR family, pyrin domain containing 3	Mus musculus	150-155
28653829-1	2017	In our efforts to develop novel small-molecule inhibitors for the NOD-like receptor family pyrin-domain-containing 3 (NLRP3) inflammasome as potential disease-modifying agents to treat neurological disorders including multiple sclerosis (MS), a hydroxyl sulfonamide analogue JC-171 has been rationally designed and biologically characterized both in vitro and in vivo.	hydroxyl sulfonamide	245-265	NLR family, pyrin domain containing 3	Mus musculus	118-123
28653829-4	2017	Furthermore, immunoprecipitation study revealed that JC-171 interfered with NLRP3/ASC interaction induced by LPS/ATP stimulation.	Adenosine Triphosphate	113-116	NLR family, pyrin domain containing 3	Mus musculus	76-81
29070054-4	2017	We investigated whether inhibition of NLRP3 inflammasome activation by the pharmacologic inhibitor BAY 11-7082 or A438079 could exert neuroprotective effects in a mouse model of SCI.	3-(4-methylphenylsulfonyl)-2-propenenitrile	99-110	NLR family, pyrin domain containing 3	Mus musculus	38-43
29070054-10	2017	RESULTS: Inhibition of NLRP3 inflammasome activation by pharmacologic inhibitor BAY 11-7082 or A438079 reduced neuronal death, attenuated spinal cord anatomic damage, and promoted motor recovery.	3-(4-methylphenylsulfonyl)-2-propenenitrile	80-91	NLR family, pyrin domain containing 3	Mus musculus	23-28
29070054-10	2017	RESULTS: Inhibition of NLRP3 inflammasome activation by pharmacologic inhibitor BAY 11-7082 or A438079 reduced neuronal death, attenuated spinal cord anatomic damage, and promoted motor recovery.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	95-102	NLR family, pyrin domain containing 3	Mus musculus	23-28
29070054-11	2017	Furthermore, BAY 11-7082 or A438079 directly attenuated the levels of NLRP3 inflammasome and proinflammatory cytokines.	3-(4-methylphenylsulfonyl)-2-propenenitrile	13-24	NLR family, pyrin domain containing 3	Mus musculus	70-75
29070054-11	2017	Furthermore, BAY 11-7082 or A438079 directly attenuated the levels of NLRP3 inflammasome and proinflammatory cytokines.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	28-35	NLR family, pyrin domain containing 3	Mus musculus	70-75
28800542-0	2017	Digitoflavone (DG) attenuates LPS-induced acute lung injury through reducing oxidative stress and inflammatory response dependent on the suppression of TXNIP/NLRP3 and NF-kappaB.	Luteolin	0-13	NLR family, pyrin domain containing 3	Mus musculus	158-163
28709622-10	2017	Moreover, similar to Nec-1, genipin attenuated GalN/LPS-induced increases in the protein expression levels of NLRP3, ASC, and caspase-1, inflammasome components, and levels of liver and serum IL-1beta.	Galactosamine	47-51	NLR family, pyrin domain containing 3	Mus musculus	110-115
28933629-10	2017	In macrophages, ezetimibe blocked the NLRP3 inflammasome-IL1B pathway in an autophagy-dependent manner and modulated hepatocyte-macrophage interaction via extracellular vesicles.	Ezetimibe	16-25	NLR family, pyrin domain containing 3	Mus musculus	38-43
28750357-0	2017	Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling.	wedelolactone	22-35	NLR family, pyrin domain containing 3	Mus musculus	115-120
28750357-5	2017	Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS.	dss	177-180	NLR family, pyrin domain containing 3	Mus musculus	65-70
28953873-5	2017	Unexpectedly, unbiased whole-transcriptome analyses of adipose macrophages revealed that ageing upregulates genes that control catecholamine degradation in an NLRP3 inflammasome-dependent manner.	Catecholamines	127-140	NLR family, pyrin domain containing 3	Mus musculus	159-164
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Catecholamines	37-50	NLR family, pyrin domain containing 3	Mus musculus	12-17
28953873-6	2017	Deletion of NLRP3 in ageing restored catecholamine-induced lipolysis by downregulating growth differentiation factor-3 (GDF3) and monoamine oxidase A (MAOA) that is known to degrade noradrenaline.	Norepinephrine	182-195	NLR family, pyrin domain containing 3	Mus musculus	12-17
28532818-0	2017	TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2",4,4"-tetrabromodiphenyl ether (BDE-47)-treated mice.	2,2',4,4'-tetrabromodiphenyl ether	87-121	NLR family, pyrin domain containing 3	Mus musculus	36-41
28938395-1	2017	Despite recent studies that show oxidative stress-generated reactive oxygen species (ROS) regulate NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated innate immune response in various diabetic complications, the mechanism by which ROS activate innate immune response is not well understood.	Reactive Oxygen Species	60-83	NLR family, pyrin domain containing 3	Mus musculus	151-156
28762847-0	2017	Inhibition of NLRP3 inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice.	cinnamaldehyde	64-78	NLR family, pyrin domain containing 3	Mus musculus	14-19
28938395-1	2017	Despite recent studies that show oxidative stress-generated reactive oxygen species (ROS) regulate NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated innate immune response in various diabetic complications, the mechanism by which ROS activate innate immune response is not well understood.	Reactive Oxygen Species	85-88	NLR family, pyrin domain containing 3	Mus musculus	151-156
28938395-1	2017	Despite recent studies that show oxidative stress-generated reactive oxygen species (ROS) regulate NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated innate immune response in various diabetic complications, the mechanism by which ROS activate innate immune response is not well understood.	Reactive Oxygen Species	261-264	NLR family, pyrin domain containing 3	Mus musculus	151-156
28938395-4	2017	In Thp1 monocytes, inhibition or ablation of AR prevented high-glucose-induced activation of NLRP3 inflammasome and caspase-1 and release of the innate immune cytokines interleukin (IL)-1beta and IL-18.	Glucose	63-70	NLR family, pyrin domain containing 3	Mus musculus	93-98
28938395-7	2017	Collectively, our data suggest that AR regulates hyperglycemia-induced NLRP3 inflammasome-mediated innate immune response by altering the ROS/Lyn/Syk/PI3K/Ca2+/K+ signals.	Reactive Oxygen Species	138-141	NLR family, pyrin domain containing 3	Mus musculus	71-76
28830026-7	2017	Furthermore, CPZ+PRO caused a significant decrease in mRNA and protein expression levels of NLRP3 and IL-18 (~2-fold), in comparison to the CPZ group.	cpz+pro	13-20	NLR family, pyrin domain containing 3	Mus musculus	92-97
28656530-4	2017	NACHT, LRR, and PYD domain-containing protein 3 (NALP3) belongs to the NLR families and recognizes adenosine triphosphate (ATP), crystals, and reactive oxygen species.	Adenosine Triphosphate	99-121	NLR family, pyrin domain containing 3	Mus musculus	49-54
28656530-4	2017	NACHT, LRR, and PYD domain-containing protein 3 (NALP3) belongs to the NLR families and recognizes adenosine triphosphate (ATP), crystals, and reactive oxygen species.	Adenosine Triphosphate	123-126	NLR family, pyrin domain containing 3	Mus musculus	49-54
28656530-4	2017	NACHT, LRR, and PYD domain-containing protein 3 (NALP3) belongs to the NLR families and recognizes adenosine triphosphate (ATP), crystals, and reactive oxygen species.	Reactive Oxygen Species	143-166	NLR family, pyrin domain containing 3	Mus musculus	49-54
28656530-11	2017	The treatment with ATP, which is a ligand to NALP3, increased the liver-to-body weight ratio in WT mice.	Adenosine Triphosphate	19-22	NLR family, pyrin domain containing 3	Mus musculus	45-50
28830026-0	2017	Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model.	Progesterone	0-12	NLR family, pyrin domain containing 3	Mus musculus	86-91
28830026-7	2017	Furthermore, CPZ+PRO caused a significant decrease in mRNA and protein expression levels of NLRP3 and IL-18 (~2-fold), in comparison to the CPZ group.	Chlorpromazine	13-16	NLR family, pyrin domain containing 3	Mus musculus	92-97
28830026-0	2017	Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model.	Cuprizone	110-119	NLR family, pyrin domain containing 3	Mus musculus	86-91
27665283-0	2017	Pterostilbene Attenuates Early Brain Injury Following Subarachnoid Hemorrhage via Inhibition of the NLRP3 Inflammasome and Nox2-Related Oxidative Stress.	pterostilbene	0-13	NLR family, pyrin domain containing 3	Mus musculus	100-105
29028430-0	2017	Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	78-83
29028430-14	2017	This study provides the first evidence that curcumin exerts protection on osteoarthritis by inhibition to the release of inflammasome NLRP3, leading to the downregulation of inflammatory cytokines.	Curcumin	44-52	NLR family, pyrin domain containing 3	Mus musculus	134-139
27665283-13	2017	In conclusion, our study suggests that PTE attenuates EBI following SAH possibly via the inhibition of NLRP3 inflammasome and Nox2-related oxidative stress.	pterostilbene	39-42	NLR family, pyrin domain containing 3	Mus musculus	103-108
27665283-10	2017	PTE treatment also reduced NLRP3 inflammasome activation.	pterostilbene	0-3	NLR family, pyrin domain containing 3	Mus musculus	27-32
29070142-4	2017	RESULTS: The allo-HSCT aGVHD mouse model was successfully established, the intraperitoneal injection of BBG alleviated the aGVHD clinical manifestations including roachback, ruffled fur, skin peeling and weight loss of recipient mice, decreased P2X7R and IL-1beta expression and reduced the mRNA levels of P2X7R, NLRP3, Caspase-1, IL-1beta and IL-18.	coomassie Brilliant Blue	104-107	NLR family, pyrin domain containing 3	Mus musculus	313-318
28791390-0	2017	Beneficial effect of magnolol on lupus nephritis in MRL/lpr mice by attenuating the NLRP3 inflammasome and NF-kappaB signaling pathway: A mechanistic analysis.	magnolol	21-29	NLR family, pyrin domain containing 3	Mus musculus	84-89
28791390-3	2017	The results of the present study demonstrated that administration of MG caused inhibition of the activation of NACHT, LRR and PYD domains-containing protein 3 and interleukin-1beta production.	magnolol	69-71	NLR family, pyrin domain containing 3	Mus musculus	111-158
28848230-5	2017	Inhibition of NLRP3 activation using the small-molecule inhibitor MCC950 resulted in reduced CHIKV-induced inflammation and abrogated osteoclastogenic bone loss and myositis, but did not affect in vivo viral replication.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	66-72	NLR family, pyrin domain containing 3	Mus musculus	14-19
28633109-3	2017	The present study tested whether acid sphingomyelinase (ASM) and ceramide associated membrane raft (MR) signaling platforms contribute to the activation of NLRP3 inflammasomes and atherosclerotic lesions during hypercholesterolemia.	Ceramides	65-73	NLR family, pyrin domain containing 3	Mus musculus	156-161
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	14-31	NLR family, pyrin domain containing 3	Mus musculus	234-239
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	NLR family, pyrin domain containing 3	Mus musculus	121-126
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	7-ketocholesterol	33-39	NLR family, pyrin domain containing 3	Mus musculus	234-239
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	Cholesterol	20-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	Cholesterol	20-31	NLR family, pyrin domain containing 3	Mus musculus	234-239
28633109-4	2017	We found that 7-ketocholesterol (7-Keto) or cholesterol crystal (ChC) markedly increased the formation and activation of NLRP3 inflammasomes in mouse carotid arterial endothelial cells (CAECs), as shown by increased colocalization of NLRP3 with ASC or caspase-1, enhanced caspase-1 activity and elevated IL-1beta levels, which were markedly attenuated by mouse Asm siRNA, ASM inhibitor- amitriptyline, and deletion of mouse Asm gene.	Amitriptyline	387-400	NLR family, pyrin domain containing 3	Mus musculus	121-126
28760679-0	2017	Amelioration of amyloid beta-induced retinal inflammatory responses by a LXR agonist TO901317 is associated with inhibition of the NF-kappaB signaling and NLRP3 inflammasome.	T0901317	85-93	NLR family, pyrin domain containing 3	Mus musculus	155-160
29031719-10	2017	NLR family pyrin domain containing 3 (Nlrp3) inflammasome activation by PA in the presence of lipopolysaccharide is also increased in Stat6-/- macrophages and to a lesser extent, in Ppardelta/gamma-/- macrophages.	Palmitic Acid	72-74	NLR family, pyrin domain containing 3	Mus musculus	0-36
29031719-10	2017	NLR family pyrin domain containing 3 (Nlrp3) inflammasome activation by PA in the presence of lipopolysaccharide is also increased in Stat6-/- macrophages and to a lesser extent, in Ppardelta/gamma-/- macrophages.	Palmitic Acid	72-74	NLR family, pyrin domain containing 3	Mus musculus	38-43
28939830-5	2017	Nlrp3-/--HFHC showed higher hepatic expression of PPAR gamma2 (that regulates lipid uptake and storage) and triglyceride content, histological score of liver injury and greater adipose tissue inflammation.	Triglycerides	108-120	NLR family, pyrin domain containing 3	Mus musculus	0-5
28963531-0	2017	Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation.	Methylene Blue	0-14	NLR family, pyrin domain containing 3	Mus musculus	24-29
28245134-9	2017	NLRP3 deficiency reduced proinflammatory LMs and increased proresolving LM, lipoxin B4 (LXB4) in septic mice, and in macrophages stimulated with LPS and ATP.	Adenosine Triphosphate	153-156	NLR family, pyrin domain containing 3	Mus musculus	0-5
29156799-0	2017	Asiatic acid protects against hepatic ischemia/reperfusion injury by inactivation of Kupffer cells via PPARgamma/NLRP3 inflammasome signaling pathway.	asiatic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	113-118
29156799-8	2017	Conversely, pharmacological inhibition of PPARgamma by GW9662 abolished the protective effects of AA on hepatic I/R injury and in turn aggravated NLRP3 inflammasome activation.	2-chloro-5-nitrobenzanilide	55-61	NLR family, pyrin domain containing 3	Mus musculus	146-151
29156799-10	2017	Depletion of KCs by gadolinium chloride (GdCl3) further attenuated the detrimental effects of GW9662 on hepatic I/R as well as NLRP3 activation.	gadolinium chloride	20-39	NLR family, pyrin domain containing 3	Mus musculus	127-132
29156799-10	2017	Depletion of KCs by gadolinium chloride (GdCl3) further attenuated the detrimental effects of GW9662 on hepatic I/R as well as NLRP3 activation.	gadolinium chloride	41-46	NLR family, pyrin domain containing 3	Mus musculus	127-132
29156799-11	2017	In vitro, AA concentration-dependently inhibited LPS/H2O2-induced NLRP3 inflammaosome activation in KCs and RAW264.7 cells.	Hydrogen Peroxide	53-57	NLR family, pyrin domain containing 3	Mus musculus	66-71
29156799-12	2017	Either GW9662 or genetic knockdown of PPARgamma abolished the AA-mediated inactivation of NLRP3 inflammasome.	2-chloro-5-nitrobenzanilide	7-13	NLR family, pyrin domain containing 3	Mus musculus	90-95
28679588-5	2017	The anti-oxidant, N-acetylcysteine, partially attenuated, whereas treatment with de novo ceramide synthesis inhibitor, myriocin, completely blocked adipose tissue inflammation and nucleotide oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3)-inflammasome activation, but not hepatic steatosis and insulin resistance induced by adipocyte raptor deletion.	Ceramides	89-97	NLR family, pyrin domain containing 3	Mus musculus	180-253
28871042-0	2017	Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.	trimethyloxamine	0-22	NLR family, pyrin domain containing 3	Mus musculus	71-76
28871042-4	2017	Here, we examined the potential role of the NLRP3 inflammasome in TMAO-induced vascular inflammation in vitro and in vivo and the underlying mechanisms.	trimethyloxamine	66-70	NLR family, pyrin domain containing 3	Mus musculus	44-49
28871042-6	2017	Moreover, TMAO promoted NLRP3 and activated caspase-1 p20 expression and caspase-1 activity in vitro and in vivo.	trimethyloxamine	10-14	NLR family, pyrin domain containing 3	Mus musculus	24-29
28871042-7	2017	Notably, a caspase-1 inhibitor (YVAD), an NLRP3 inhibitor (MCC950), as well as NLRP3 short interfering RNA attenuated TMAO-induced activation of the NLRP3 inflammasome, subsequently leading to suppression of inflammation in HUVECs.	trimethyloxamine	118-122	NLR family, pyrin domain containing 3	Mus musculus	42-47
28871042-7	2017	Notably, a caspase-1 inhibitor (YVAD), an NLRP3 inhibitor (MCC950), as well as NLRP3 short interfering RNA attenuated TMAO-induced activation of the NLRP3 inflammasome, subsequently leading to suppression of inflammation in HUVECs.	trimethyloxamine	118-122	NLR family, pyrin domain containing 3	Mus musculus	79-84
28871042-7	2017	Notably, a caspase-1 inhibitor (YVAD), an NLRP3 inhibitor (MCC950), as well as NLRP3 short interfering RNA attenuated TMAO-induced activation of the NLRP3 inflammasome, subsequently leading to suppression of inflammation in HUVECs.	trimethyloxamine	118-122	NLR family, pyrin domain containing 3	Mus musculus	79-84
28871042-9	2017	TMAO-induced endothelial NLRP3 inflammasome activation was ameliorated by the mitochondrial ROS scavenger Mito-TEMPO, or SIRT3 overexpression in HUVECs.	trimethyloxamine	0-4	NLR family, pyrin domain containing 3	Mus musculus	25-30
28871042-9	2017	TMAO-induced endothelial NLRP3 inflammasome activation was ameliorated by the mitochondrial ROS scavenger Mito-TEMPO, or SIRT3 overexpression in HUVECs.	Reactive Oxygen Species	92-95	NLR family, pyrin domain containing 3	Mus musculus	25-30
28871042-11	2017	CONCLUSIONS: TMAO promoted vascular inflammation by activating the NLRP3 inflammasome, and the NLRP3 inflammasome activation in part was mediated through inhibition of the SIRT3-SOD2-mitochondrial ROS signaling pathway.	trimethyloxamine	13-17	NLR family, pyrin domain containing 3	Mus musculus	67-72
28871042-11	2017	CONCLUSIONS: TMAO promoted vascular inflammation by activating the NLRP3 inflammasome, and the NLRP3 inflammasome activation in part was mediated through inhibition of the SIRT3-SOD2-mitochondrial ROS signaling pathway.	Reactive Oxygen Species	197-200	NLR family, pyrin domain containing 3	Mus musculus	95-100
28703484-0	2017	Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.	Sulfonylurea Compounds	0-13	NLR family, pyrin domain containing 3	Mus musculus	55-60
28703484-5	2017	We report the synthesis and biological evaluation of nine sulfonylureas that inhibit NLRP3 activation in murine bone-marrow- derived macrophages in a potent, dose-dependent manner.	Sulfonylurea Compounds	58-71	NLR family, pyrin domain containing 3	Mus musculus	85-90
28865486-6	2017	NLRP3 inflammasome activated by LPS and ATP promoted sphere-forming and colony formation capacities along with an upregulation of BMI1, ALDH1 and CD44.	Adenosine Triphosphate	40-43	NLR family, pyrin domain containing 3	Mus musculus	0-5
28865486-7	2017	In addition, NLRP3 inflammasome blockade by NLRP3 inhibitor MCC950 reduced sphere and colony number, also decreased the expression of BMI1, ALDH1 and CD44 in SCCHN cell lines.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	60-66	NLR family, pyrin domain containing 3	Mus musculus	13-18
28865486-7	2017	In addition, NLRP3 inflammasome blockade by NLRP3 inhibitor MCC950 reduced sphere and colony number, also decreased the expression of BMI1, ALDH1 and CD44 in SCCHN cell lines.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	60-66	NLR family, pyrin domain containing 3	Mus musculus	44-49
28729463-1	2017	Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood.	Fatty Acids, Unsaturated	8-13	NLR family, pyrin domain containing 3	Mus musculus	165-170
28679588-5	2017	The anti-oxidant, N-acetylcysteine, partially attenuated, whereas treatment with de novo ceramide synthesis inhibitor, myriocin, completely blocked adipose tissue inflammation and nucleotide oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3)-inflammasome activation, but not hepatic steatosis and insulin resistance induced by adipocyte raptor deletion.	thermozymocidin	119-127	NLR family, pyrin domain containing 3	Mus musculus	180-253
28729463-1	2017	Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how nucleotide-binding oligomerization domain leucine-rich repeat-containing receptor protein (NLRP3) inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood.	Fatty Acids, Unsaturated	8-12	NLR family, pyrin domain containing 3	Mus musculus	165-170
28679588-5	2017	The anti-oxidant, N-acetylcysteine, partially attenuated, whereas treatment with de novo ceramide synthesis inhibitor, myriocin, completely blocked adipose tissue inflammation and nucleotide oligomerization domain-like receptor pyrin domain-containing 3 (NLRP3)-inflammasome activation, but not hepatic steatosis and insulin resistance induced by adipocyte raptor deletion.	thermozymocidin	119-127	NLR family, pyrin domain containing 3	Mus musculus	255-260
28903492-0	2017	Editor"s Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.	Rotenone	120-128	NLR family, pyrin domain containing 3	Mus musculus	20-25
28814068-1	2017	BACKGROUND/AIMS: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome.	Reactive Oxygen Species	70-93	NLR family, pyrin domain containing 3	Mus musculus	226-231
28814068-5	2017	The expression levels of the NLRP3-inflammasome and caspase-1 were upregulated in RAW 264.7 cells by stimulation with CSE and DEPs and were inhibited by NAC.	Acetylcysteine	153-156	NLR family, pyrin domain containing 3	Mus musculus	29-34
28814068-9	2017	NLRP3-inflammasome expression as determined by immunohistochemistry was increased by CSE and DEPs in both the normal and elastin-induced emphysema groups, and was suppressed by NAC.	Acetylcysteine	177-180	NLR family, pyrin domain containing 3	Mus musculus	0-5
28814068-10	2017	CONCLUSIONS: The NLRP3-inf lammasome is activated by DEPs in ex vivo tissue explants from elastase-induced emphysema animal model, and this activation is inhibited by NAC.	Acetylcysteine	167-170	NLR family, pyrin domain containing 3	Mus musculus	17-22
28669709-0	2017	A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells.	Curcumin	27-35	NLR family, pyrin domain containing 3	Mus musculus	77-82
28669709-0	2017	A mechanistic insight into curcumin modulation of the IL-1beta secretion and NLRP3 S-glutathionylation induced by needle-like cationic cellulose nanocrystals in myeloid cells.	Cellulose	135-144	NLR family, pyrin domain containing 3	Mus musculus	77-82
28669709-1	2017	Recently we have demonstrated that needle-like cationic cellulose nanocrystals (CNC-AEMA2) evoke immunological responses through NLRP3 inflammasome/IL-1beta inflammatory pathway.	Cellulose	56-65	NLR family, pyrin domain containing 3	Mus musculus	129-134
28669709-5	2017	We hypothesize that curcumin may also affect S-glutathionylation of key proteins involved in the NLRP3 inflammasome/IL-1beta pathway, and therefore impact their protein-protein interactions.	Curcumin	20-28	NLR family, pyrin domain containing 3	Mus musculus	97-102
28669709-6	2017	The goal of this study was to investigate the effects of curcumin on the S-glutathionylation of NLRP3 induced by CNC-AEMA2 in LPS-primed mouse macrophages (J774A.1), as well as interactions among proteins of the NLRP3 inflammasome complex.	Curcumin	57-65	NLR family, pyrin domain containing 3	Mus musculus	96-101
28669709-7	2017	Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S-glutathionylation and a respective increase in caspase-1 S-glutathionylation, which appears to favor protein-protein interactions in the NLRP3 complex.	Curcumin	48-56	NLR family, pyrin domain containing 3	Mus musculus	112-117
28669709-7	2017	Our main finding indicates that the addition of curcumin concomitantly with LPS caused the greatest decrease in NLRP3 S-glutathionylation and a respective increase in caspase-1 S-glutathionylation, which appears to favor protein-protein interactions in the NLRP3 complex.	Curcumin	48-56	NLR family, pyrin domain containing 3	Mus musculus	257-262
28669709-8	2017	Taking together, our results suggest that, at least in part, the anti-inflammatory activity of curcumin is associated with changes in S-glutathionylation of key NLRP3 inflammasome components, and perhaps resulting in sustained complex assembly and suppression of IL-1beta secretion.	Curcumin	95-103	NLR family, pyrin domain containing 3	Mus musculus	161-166
28647362-6	2017	Interesting, GW4064 suppresses NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome mediates tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta, as well as mitochondrial respiratory complexes mRNA expression in WT and FXR KO mice treated with LPS.	GW 4064	13-19	NLR family, pyrin domain containing 3	Mus musculus	31-78
28647362-6	2017	Interesting, GW4064 suppresses NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome mediates tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta, as well as mitochondrial respiratory complexes mRNA expression in WT and FXR KO mice treated with LPS.	GW 4064	13-19	NLR family, pyrin domain containing 3	Mus musculus	80-85
28903492-7	2017	Analysis of brain tissues revealed Nlrp3-dependent neuroinflammation and nigral cell loss in mice exposed to rotenone as compared with mice exposed to vehicle alone.	Rotenone	109-117	NLR family, pyrin domain containing 3	Mus musculus	35-40
28903492-8	2017	Together, our findings provide compelling evidence of a role for Nlrp3 in nigral degeneration and neuroinflammation resulting from systemic rotenone exposure and suggest that the suppression of NLRP3 activity may be a rational neuroprotective strategy for toxin-associated PD.	Rotenone	140-148	NLR family, pyrin domain containing 3	Mus musculus	65-70
28786950-12	2017	In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD+ level to inhibit NLRP3 inflammasome activation.	NAD	80-84	NLR family, pyrin domain containing 3	Mus musculus	102-107
28623127-0	2017	The inhibition of NLRP3 signaling attenuates liver injury in an alpha-galactosylceramide-induced hepatitis model.	alpha-galactosylceramide	64-88	NLR family, pyrin domain containing 3	Mus musculus	18-23
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Adenosine Triphosphate	97-119	NLR family, pyrin domain containing 3	Mus musculus	0-47
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Adenosine Triphosphate	97-119	NLR family, pyrin domain containing 3	Mus musculus	49-54
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Adenosine Triphosphate	121-124	NLR family, pyrin domain containing 3	Mus musculus	0-47
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Adenosine Triphosphate	121-124	NLR family, pyrin domain containing 3	Mus musculus	49-54
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Reactive Oxygen Species	141-164	NLR family, pyrin domain containing 3	Mus musculus	0-47
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Reactive Oxygen Species	141-164	NLR family, pyrin domain containing 3	Mus musculus	49-54
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Reactive Oxygen Species	166-169	NLR family, pyrin domain containing 3	Mus musculus	0-47
28623127-3	2017	NACHT, LRR and PYD domains-containing protein 3 (NALP3) belongs to the NLR family and recognizes adenosine triphosphate (ATP), crystals, and Reactive Oxygen Species (ROS).	Reactive Oxygen Species	166-169	NLR family, pyrin domain containing 3	Mus musculus	49-54
28401330-0	2017	Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.	cordycepin	0-10	NLR family, pyrin domain containing 3	Mus musculus	94-99
28544564-5	2017	MCC950, a selective inhibitor of NLRP3, was used to treat NZM2328 mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	0-6	NLR family, pyrin domain containing 3	Mus musculus	33-38
28544564-10	2017	In vitro, sera from diseased NZM2328 mice activated NLRP3 inflammasomes in the podocyte cell line through the production of reactive oxygen species.	Reactive Oxygen Species	124-147	NLR family, pyrin domain containing 3	Mus musculus	52-57
28370493-2	2017	Moreover, melatonin blunts the NF-kappaB/NLRP3 connection during sepsis.	Melatonin	10-19	NLR family, pyrin domain containing 3	Mus musculus	41-46
28370493-12	2017	The efficacy of melatonin in counteracting the NLRP3 inflammasome activation further confirms the indoleamine as a useful therapeutic drug against this serious condition.	Melatonin	16-25	NLR family, pyrin domain containing 3	Mus musculus	47-52
28370493-12	2017	The efficacy of melatonin in counteracting the NLRP3 inflammasome activation further confirms the indoleamine as a useful therapeutic drug against this serious condition.	indolamine	98-109	NLR family, pyrin domain containing 3	Mus musculus	47-52
28394319-8	2017	We also examined the effect of homocysteine (Hcy) on NLRP3 inflammasome activation in THP-1-differentiated macrophages in the presence or absence of NLRP3 siRNA or the caspase-1 inhibitor Z-WEHD-FMK.	Homocysteine	45-48	NLR family, pyrin domain containing 3	Mus musculus	53-58
28394319-10	2017	As reactive oxygen species (ROS) may have a central role in NLRP3 inflammasome activation, we next investigated whether antioxidant N-acetyl-l-cysteine (NAC) prevented Hcy-induced NLRP3 inflammasome activation in macrophages.	Homocysteine	168-171	NLR family, pyrin domain containing 3	Mus musculus	180-185
28394319-11	2017	We found Hcy-induced NLRP3 inflammasome activation was abolished by NAC.	Homocysteine	9-12	NLR family, pyrin domain containing 3	Mus musculus	21-26
28394319-11	2017	We found Hcy-induced NLRP3 inflammasome activation was abolished by NAC.	Acetylcysteine	68-71	NLR family, pyrin domain containing 3	Mus musculus	21-26
28394319-12	2017	Treatment with NAC in HHcy mice also suppressed NLRP3 inflammasome activation and improved HHcy-induced atherosclerosis.	Acetylcysteine	15-18	NLR family, pyrin domain containing 3	Mus musculus	48-53
28394319-14	2017	Hcy activates NLRP3 inflammasomes in ROS-dependent pathway in macrophages.	Homocysteine	0-3	NLR family, pyrin domain containing 3	Mus musculus	14-19
28394319-14	2017	Hcy activates NLRP3 inflammasomes in ROS-dependent pathway in macrophages.	Reactive Oxygen Species	37-40	NLR family, pyrin domain containing 3	Mus musculus	14-19
28596375-0	2017	NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	33-39	NLR family, pyrin domain containing 3	Mus musculus	0-5
28410265-0	2017	Mangiferin inhibits hippocampal NLRP3 inflammasome and exerts antidepressant effects in a chronic mild stress mice model.	mangiferin	0-10	NLR family, pyrin domain containing 3	Mus musculus	32-37
31966664-0	2017	Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation.	obeticholic acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	75-80
31966664-2	2017	Our aim was to investigate whether the therapeutic effect of OCA on NASH was attributed to its inhibition effect on cytosolic sensor NLR family pyrin domain containing 3 (NLRP3) inflammasome activation.	octyl-4-chloroacetoacetate	61-64	NLR family, pyrin domain containing 3	Mus musculus	133-169
31966664-2	2017	Our aim was to investigate whether the therapeutic effect of OCA on NASH was attributed to its inhibition effect on cytosolic sensor NLR family pyrin domain containing 3 (NLRP3) inflammasome activation.	octyl-4-chloroacetoacetate	61-64	NLR family, pyrin domain containing 3	Mus musculus	171-176
31966664-5	2017	After daily gavage of 0.4 mg of OCA or vehicle for 24 days, we evaluated the direct effect of OCA on NLRP3 inflammasome activation by analyzing the expressions of NLRP3 and IL-1beta.	octyl-4-chloroacetoacetate	94-97	NLR family, pyrin domain containing 3	Mus musculus	101-106
31966664-9	2017	We also found that short-term OCA treatment could significantly down-regulate the expressions of NLRP3 and IL-1beta and therefore improved NASH-associated steatosis and inflammation.	octyl-4-chloroacetoacetate	30-33	NLR family, pyrin domain containing 3	Mus musculus	97-102
31966664-10	2017	CONCLUSIONS: NLRP3 inflammasome could be activated and might have an essential role in NASH progression, and short-term OCA treatment could have a potential therapeutic effect on NASH-associated steatosis and inflammation by inhibiting NLRP3 inflammasome activation.	octyl-4-chloroacetoacetate	120-123	NLR family, pyrin domain containing 3	Mus musculus	236-241
28398673-4	2017	Here, we demonstrated that melatonin alleviated lipopolysaccharides (LPS)-induced inflammation and NLRP3 inflammasome formation in mice adipose tissue.	Melatonin	27-36	NLR family, pyrin domain containing 3	Mus musculus	99-104
28398673-5	2017	The NLRP3 inflammasome-mediated pyroptosis was also inhibited by melatonin in adipocytes.	Melatonin	65-74	NLR family, pyrin domain containing 3	Mus musculus	4-9
28398673-10	2017	Melatonin also attenuated NLRP3 inflammasome activation and pyroptosis, which was induced by LPS or obesity.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	26-31
28404518-5	2017	In the DRG explant culture, after treatment with TNF-alpha, the expression of IL-1beta, NLRP3, and caspase 1 was significantly increased but this was reversed by the addition of fullerol.	fullerol	178-186	NLR family, pyrin domain containing 3	Mus musculus	88-93
28765650-6	2017	This decrease was associated with an inhibition of the activation of p38MAPK, JNK, NF-kappaB and NLRP3 inflammasome leading to a reduction of IL-1beta secretion in response to LPS and ATP in REDD1-/- BMDM.	Adenosine Triphosphate	184-187	NLR family, pyrin domain containing 3	Mus musculus	97-102
28463821-0	2017	Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.	ros	14-17	NLR family, pyrin domain containing 3	Mus musculus	86-91
28463821-0	2017	Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.	Ethanol	37-44	NLR family, pyrin domain containing 3	Mus musculus	86-91
28463821-3	2017	We hypothesized that protracted exposure of leukocytes to ethanol would amplify inflammasome activation, which would help to implicate mechanisms involved in diseases associated with both alcoholism and aberrant NLRP3 inflammasome activation.	Ethanol	58-65	NLR family, pyrin domain containing 3	Mus musculus	212-217
28463821-4	2017	Here we show that long-term ethanol exposure of human peripheral blood mononuclear cells and a mouse macrophage cell line (J774) amplifies IL-1beta secretion following stimulation with NLRP3 agonists, but not with AIM2 or NLRP1b agonists.	Ethanol	28-35	NLR family, pyrin domain containing 3	Mus musculus	185-190
28463821-8	2017	Together, these results indicate that increases in iNOS and mitochondrial ROS production are critical for chronic ethanol-induced IL-1beta hypersecretion, and that protracted exposure to the products of ethanol metabolism are probable mediators of NLRP3 inflammasome hyperactivation.	Ethanol	114-121	NLR family, pyrin domain containing 3	Mus musculus	248-253
28463821-8	2017	Together, these results indicate that increases in iNOS and mitochondrial ROS production are critical for chronic ethanol-induced IL-1beta hypersecretion, and that protracted exposure to the products of ethanol metabolism are probable mediators of NLRP3 inflammasome hyperactivation.	Ethanol	203-210	NLR family, pyrin domain containing 3	Mus musculus	248-253
28740109-6	2017	Dimethyloxalylglycine-mediated hydroxylase inhibition ameliorates colitis in mice, downregulates NLRP3 and promotes autophagy.	oxalylglycine	0-21	NLR family, pyrin domain containing 3	Mus musculus	97-102
28420825-7	2017	Histological and gene expression analysis revealed colchicine significantly inhibited the infiltration of neutrophils and macrophages, and attenuated the mRNA expression of pro-inflammatory cytokines and NLRP3 inflammasome components in the infarcted myocardium at 24 h after MI.	Colchicine	51-61	NLR family, pyrin domain containing 3	Mus musculus	204-209
28420825-8	2017	CONCLUSIONS: Short-term treatment with colchicine successfully attenuated pro-inflammatory cytokines and NLRP3 inflammasome, and improved cardiac function, heart failure, and survival after MI.	Colchicine	39-49	NLR family, pyrin domain containing 3	Mus musculus	105-110
28791016-0	2017	Doxycycline Attenuates Leptospira-Induced IL-1beta by Suppressing NLRP3 Inflammasome Priming.	Doxycycline	0-11	NLR family, pyrin domain containing 3	Mus musculus	66-71
28791016-8	2017	Meanwhile, Dox suppressed leptospira-induced NLRP3 inflammasome priming with the upregulation of the Na/K-ATPase Pump beta1 subunit.	Doxycycline	11-14	NLR family, pyrin domain containing 3	Mus musculus	45-50
28791016-11	2017	Our results indicated that Dox also modulated immune response to attenuate leptospira-induced IL-1beta by suppressing p38, JNK, p65, and NLRP3 inflammasome priming.	Doxycycline	27-30	NLR family, pyrin domain containing 3	Mus musculus	137-142
28938606-0	2017	Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	0-10	NLR family, pyrin domain containing 3	Mus musculus	44-49
28938606-2	2017	The aim of this study was to investigate the anti-inflammatory effect of a bioactive flavonoid-oroxylin A on the treatment of dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome.	flavonoid-oroxylin a	85-105	NLR family, pyrin domain containing 3	Mus musculus	192-197
28938606-5	2017	Moreover, oroxylin A significantly decreased the expression of NLRP3 in intestinal mucosal tissue.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	10-20	NLR family, pyrin domain containing 3	Mus musculus	63-68
28938606-7	2017	Further study found that the activation of NLRP3 inflammasome was dose-dependently inhibited by oroxylin A in both THP-Ms and BMDMs, followed by decrease in the cleavage of caspase-1 and secretion of IL-1beta.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	96-106	NLR family, pyrin domain containing 3	Mus musculus	43-48
28938606-8	2017	This inhibitory effect of oroxylin A was due to restraint of the NLRP3 protein expression and the inflammasome formation in macrophages.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	26-36	NLR family, pyrin domain containing 3	Mus musculus	65-70
28938606-9	2017	Furthermore, the reduction of NLRP3 protein expression by oroxylin A was dependent on the inhibition of NF-kappaB p65 expression and nuclear translocation.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	58-68	NLR family, pyrin domain containing 3	Mus musculus	30-35
28938606-2	2017	The aim of this study was to investigate the anti-inflammatory effect of a bioactive flavonoid-oroxylin A on the treatment of dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome.	Dextran Sulfate	126-148	NLR family, pyrin domain containing 3	Mus musculus	192-197
28938606-10	2017	Besides, oroxylin A directly suppressed the ASC speck formation and the inflammasome assembly which in turn restrained the activation of NLRP3 inflammasome.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	9-19	NLR family, pyrin domain containing 3	Mus musculus	137-142
28938606-11	2017	Our findings demonstrated that oroxylin A inhibited NLRP3 inflammasome activation and could potentially be used for the treatment of IBD.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	31-41	NLR family, pyrin domain containing 3	Mus musculus	52-57
28938606-2	2017	The aim of this study was to investigate the anti-inflammatory effect of a bioactive flavonoid-oroxylin A on the treatment of dextran sulfate sodium (DSS)-induced murine colitis via targeting NLRP3 inflammasome.	Dextran Sulfate	150-153	NLR family, pyrin domain containing 3	Mus musculus	192-197
28584055-5	2017	In SIRT3 knock-out bone marrow-derived macrophages, NLRP3 activation promoted excess cytosolic extrusion of mitochondrial DNA along with increased reactive oxygen species and reduced superoxide dismutase 2 (SOD2) activity.	Reactive Oxygen Species	147-170	NLR family, pyrin domain containing 3	Mus musculus	52-57
26848183-4	2017	DESIGN: Wild-type and NLRP3-deficient mice with dextran sodium sulfate-induced colitis were orally administered with TiO2 nanoparticles.	dextran sodium sulfate	48-70	NLR family, pyrin domain containing 3	Mus musculus	22-27
28732510-8	2017	2ccPA treatment reduced cuprizone-induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction.	2-carba-cyclic phosphatidic acid	0-5	NLR family, pyrin domain containing 3	Mus musculus	80-85
28726774-10	2017	Moreover, IL-22 markedly downregulated high glucose-induced activation of NLRP3 inflammasome in renal mesangial cells in a dose-dependent manner, indicating that the effects of IL-22 on NLRP3 inflammasome activation was independent of improved glycemic control.	Glucose	44-51	NLR family, pyrin domain containing 3	Mus musculus	74-79
28726774-10	2017	Moreover, IL-22 markedly downregulated high glucose-induced activation of NLRP3 inflammasome in renal mesangial cells in a dose-dependent manner, indicating that the effects of IL-22 on NLRP3 inflammasome activation was independent of improved glycemic control.	Glucose	44-51	NLR family, pyrin domain containing 3	Mus musculus	186-191
28590715-3	2017	Recently, studies have indicated that the activation of NLRP3 inflammasome plays a critical role in inducing adjuvant effects that are controlled by the inherent shape and hydroxyl contents of aluminum oxyhydroxide (AlOOH) nanoparticles; however, the detailed relationship between surface properties and adjuvant effects for these materials remains unknown.	Hydroxyl Radical	172-180	NLR family, pyrin domain containing 3	Mus musculus	56-61
28590715-3	2017	Recently, studies have indicated that the activation of NLRP3 inflammasome plays a critical role in inducing adjuvant effects that are controlled by the inherent shape and hydroxyl contents of aluminum oxyhydroxide (AlOOH) nanoparticles; however, the detailed relationship between surface properties and adjuvant effects for these materials remains unknown.	Boehmite	193-214	NLR family, pyrin domain containing 3	Mus musculus	56-61
28590715-3	2017	Recently, studies have indicated that the activation of NLRP3 inflammasome plays a critical role in inducing adjuvant effects that are controlled by the inherent shape and hydroxyl contents of aluminum oxyhydroxide (AlOOH) nanoparticles; however, the detailed relationship between surface properties and adjuvant effects for these materials remains unknown.	alooh	216-221	NLR family, pyrin domain containing 3	Mus musculus	56-61
28320049-7	2017	DBHB treatment suppressed SCI-induced NLRP3 inflammasome activation and reduced protein expression of IL-1beta and IL-18.	DBHB	0-4	NLR family, pyrin domain containing 3	Mus musculus	38-43
28320049-9	2017	CONCLUSIONS AND IMPLICATIONS: DBHB promoted functional recovery and relieved pain hypersensitivity in mice with SCI, possibly through inhibition of histone deacetylation and NLRP3 inflammasome activation and preservation of mitochondrial function.	DBHB	30-34	NLR family, pyrin domain containing 3	Mus musculus	174-179
28708885-0	2017	Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus.	Pioglitazone	0-12	NLR family, pyrin domain containing 3	Mus musculus	36-41
28740491-3	2017	Various molecular mechanisms were associated with NLRP3 activation including the presence of extracellular ATP, recognized by the cell surface P2X7 receptor (P2X7R).	Adenosine Triphosphate	107-110	NLR family, pyrin domain containing 3	Mus musculus	50-55
26848183-4	2017	DESIGN: Wild-type and NLRP3-deficient mice with dextran sodium sulfate-induced colitis were orally administered with TiO2 nanoparticles.	titanium dioxide	117-121	NLR family, pyrin domain containing 3	Mus musculus	22-27
28378341-5	2017	Importantly, overexpression of NLRP3 was strongly associated with poor liver function characterized by high levels of ALT, AST, and urea, as well as neutrophil infiltration after transplantation.	Urea	132-136	NLR family, pyrin domain containing 3	Mus musculus	31-36
28087651-5	2017	In contrast, nigericin, a soluble activator of NLRP3 inflammasomes, induced cell death that was dependent on the NLRP3.	Nigericin	13-22	NLR family, pyrin domain containing 3	Mus musculus	47-52
28179433-5	2017	Compared with UUO-treated wild-type mice, UUO-treated IL-36 knockout mice exhibited markedly reduced NLRP3 inflammasome activation and macrophage/T cell infiltration in the kidney and T cell activation in the renal draining lymph nodes.	uuo	42-45	NLR family, pyrin domain containing 3	Mus musculus	101-106
28087651-5	2017	In contrast, nigericin, a soluble activator of NLRP3 inflammasomes, induced cell death that was dependent on the NLRP3.	Nigericin	13-22	NLR family, pyrin domain containing 3	Mus musculus	113-118
28216285-6	2017	The NLRP3 inflammasome activation was increased in type 2 diabetic mice and treatment of diabetic aortic segments with MCC950, a potent selective inhibitor of NLRP3 inflammasome ex vivo improved endothelial-dependent vasorelaxation.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	119-125	NLR family, pyrin domain containing 3	Mus musculus	4-9
28637493-0	2017	The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma.	Fluorouracil	34-48	NLR family, pyrin domain containing 3	Mus musculus	12-17
28637493-3	2017	In this study, we explored the role of NLRP3 inflammasome in 5-FU resistance of oral squamous cell carcinoma (OSCC).	Fluorouracil	61-65	NLR family, pyrin domain containing 3	Mus musculus	39-44
28637493-6	2017	The correlation between 5-FU treatment and the expression and activation of NLRP3 inflammasome was further examined by evaluating NLRP3 and IL-1beta expression in OSCC cell lines without or with NLRP3 knocked down.	Fluorouracil	24-28	NLR family, pyrin domain containing 3	Mus musculus	76-81
28637493-6	2017	The correlation between 5-FU treatment and the expression and activation of NLRP3 inflammasome was further examined by evaluating NLRP3 and IL-1beta expression in OSCC cell lines without or with NLRP3 knocked down.	Fluorouracil	24-28	NLR family, pyrin domain containing 3	Mus musculus	130-135
28637493-6	2017	The correlation between 5-FU treatment and the expression and activation of NLRP3 inflammasome was further examined by evaluating NLRP3 and IL-1beta expression in OSCC cell lines without or with NLRP3 knocked down.	Fluorouracil	24-28	NLR family, pyrin domain containing 3	Mus musculus	130-135
28637493-13	2017	Moreover, 5-FU treatment increased expression and activation of NLRP3 inflammasome in OSCC cells in a cell culture system and xenograft mouse model.	Fluorouracil	10-14	NLR family, pyrin domain containing 3	Mus musculus	64-69
28637493-14	2017	Silencing of NLRP3 expression significantly inhibited OSCC cell proliferation and enhanced 5-FU-induced apoptosis of OSCC cells.	Fluorouracil	91-95	NLR family, pyrin domain containing 3	Mus musculus	13-18
28637493-15	2017	Further investigation showed that intracellular ROS induced by 5-FU promoted the expression and activation of NLRP3 inflammasome and increased the production of interleukin (IL)-1beta, which then mediated the chemoresistance.	Reactive Oxygen Species	48-51	NLR family, pyrin domain containing 3	Mus musculus	110-115
28637493-15	2017	Further investigation showed that intracellular ROS induced by 5-FU promoted the expression and activation of NLRP3 inflammasome and increased the production of interleukin (IL)-1beta, which then mediated the chemoresistance.	Fluorouracil	63-67	NLR family, pyrin domain containing 3	Mus musculus	110-115
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Fluorouracil	67-71	NLR family, pyrin domain containing 3	Mus musculus	39-44
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Reactive Oxygen Species	136-139	NLR family, pyrin domain containing 3	Mus musculus	140-145
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Fluorouracil	195-199	NLR family, pyrin domain containing 3	Mus musculus	39-44
28637493-18	2017	CONCLUSIONS: Our findings suggest that NLRP3 inflammasome promoted 5-FU resistance of OSCC both in vitro and in vivo, and targeting the ROS/NLRP3 inflammasome/IL-1beta signaling pathway may help 5-FU-based adjuvant chemotherapy of OSCC.	Fluorouracil	195-199	NLR family, pyrin domain containing 3	Mus musculus	140-145
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	28-41	NLR family, pyrin domain containing 3	Mus musculus	57-62
28499273-2	2017	It has been also shown that palmitic acid (PA) activates NLRP3 inflammasome and promotes interleukin-1beta (IL-1beta) secretion in Kupffer cells (KCs).	Palmitic Acid	43-45	NLR family, pyrin domain containing 3	Mus musculus	57-62
28499273-8	2017	PA triggered the activation and co-localization of the NLRP3 inflammasome protein complex in KCs isolated from WT and TXNIP-/- but not NLRP3-/- mice, and most of the complex co-localized with mitochondria of KCs following PA stimulation.	Palmitic Acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	55-60
28499273-8	2017	PA triggered the activation and co-localization of the NLRP3 inflammasome protein complex in KCs isolated from WT and TXNIP-/- but not NLRP3-/- mice, and most of the complex co-localized with mitochondria of KCs following PA stimulation.	Palmitic Acid	222-224	NLR family, pyrin domain containing 3	Mus musculus	55-60
28752965-0	2017	[The Effect of Sodium Ferulate in Experimental Pulmonary Fibrosis via NALP3 Inflammasome].	ferulic acid	15-30	NLR family, pyrin domain containing 3	Mus musculus	70-75
28752965-1	2017	OBJECTIVE: To investigate the activation of NALP3 inflammasome in the process of experimental pulmonary fibrosis (PF), and evaluate the effect of sodium ferulate (SF) in the relationship of NALP3 and PF.	ferulic acid	146-161	NLR family, pyrin domain containing 3	Mus musculus	190-195
28752965-1	2017	OBJECTIVE: To investigate the activation of NALP3 inflammasome in the process of experimental pulmonary fibrosis (PF), and evaluate the effect of sodium ferulate (SF) in the relationship of NALP3 and PF.	ferulic acid	163-165	NLR family, pyrin domain containing 3	Mus musculus	190-195
28752965-12	2017	in vitroexperiment, H2O2 increased NALP3 (P&lt;0.05), ASC (P&lt;0.01), caspase-1 (P&lt;0.05) expressions and IL-1beta releasing (P&lt;0.05)and promoted the expressions of collagen-1 and alpha-SMA in both gene and protein levels (P&lt;0.05) in NIH-3T3.	Hydrogen Peroxide	20-24	NLR family, pyrin domain containing 3	Mus musculus	35-40
28752965-13	2017	NALP3 activation was partly inhibited in H2O2+SF group (P&lt;0.05).	Hydrogen Peroxide	41-45	NLR family, pyrin domain containing 3	Mus musculus	0-5
28752965-15	2017	CONCLUSION: Sodium ferulate may suppress oxidative stress mediated NALP3 activation to inhibit fibroblast activation in the anti-fibrosis effect.	ferulic acid	12-27	NLR family, pyrin domain containing 3	Mus musculus	67-72
28623945-0	2017	Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis.	mir-155	0-7	NLR family, pyrin domain containing 3	Mus musculus	79-84
28216285-6	2017	The NLRP3 inflammasome activation was increased in type 2 diabetic mice and treatment of diabetic aortic segments with MCC950, a potent selective inhibitor of NLRP3 inflammasome ex vivo improved endothelial-dependent vasorelaxation.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	119-125	NLR family, pyrin domain containing 3	Mus musculus	159-164
28216285-9	2017	Inhibition of peroxynitrite formation preferentially attenuated NLRP3 inflammasome activation in APN-KO diabetic mice.	Peroxynitrous Acid	14-27	NLR family, pyrin domain containing 3	Mus musculus	64-69
28603491-13	2017	Moreover, the TLR4/MyD88/NF-kappaB pathway and NLRP3 inflammasome were involved in the inhibitory effects of NOSH-NBP on M1 polarization, while peroxisome proliferator activated receptor gamma signaling contributed to NOSH-NBP induced M2 polarization.	nosh-nbp	109-117	NLR family, pyrin domain containing 3	Mus musculus	47-52
28286920-8	2017	However, TLR4 KO mice that received DAPT reduced APAP-induced liver damage and NF-kappaB, NLRP3, and cleaved caspase-1 activation.	dapt	36-40	NLR family, pyrin domain containing 3	Mus musculus	90-95
28286920-11	2017	These results demonstrate that Notch signaling regulates innate NLRP3 inflammasome activation through regulation of HMGB1/TLR4/NF-kappaB activation in APAP-induced liver injury.	Acetaminophen	151-155	NLR family, pyrin domain containing 3	Mus musculus	64-69
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	Acetaminophen	8-19	NLR family, pyrin domain containing 3	Mus musculus	327-332
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	Acetaminophen	20-33	NLR family, pyrin domain containing 3	Mus musculus	327-332
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	NLR family, pyrin domain containing 3	Mus musculus	327-332
28096454-0	2017	Mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	53-56	NLR family, pyrin domain containing 3	Mus musculus	65-70
28096454-3	2017	Here, we show that mitochondrial function is required for extracellular ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	72-75	NLR family, pyrin domain containing 3	Mus musculus	84-89
28096454-6	2017	CCCP did not inhibit the ATP-induced generation of reactive oxygen species and cell death, both of which are known to promote IL-1beta release, but did inhibit the ATP-induced activation of caspase-1, a component of the NLRP3 inflammasome.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	0-4	NLR family, pyrin domain containing 3	Mus musculus	220-225
28096454-6	2017	CCCP did not inhibit the ATP-induced generation of reactive oxygen species and cell death, both of which are known to promote IL-1beta release, but did inhibit the ATP-induced activation of caspase-1, a component of the NLRP3 inflammasome.	Adenosine Triphosphate	164-167	NLR family, pyrin domain containing 3	Mus musculus	220-225
28096454-7	2017	These results suggest that mitochondrial function is required somewhat specifically for ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	88-91	NLR family, pyrin domain containing 3	Mus musculus	100-105
27993998-5	2017	The NLRP3 inflammasome components were studied by sucrose density gradient fractionation, chemical cross-linking, and co-immunoprecipitation.	Sucrose	50-57	NLR family, pyrin domain containing 3	Mus musculus	4-9
27993998-10	2017	In the absence of IL-10, NLRP3 inflammasome was spontaneously active and more robustly responsive when activated by LPS and nigericin.	Nigericin	124-133	NLR family, pyrin domain containing 3	Mus musculus	25-30
27993998-11	2017	Glyburide markedly suppressed NLRP3 inflammasome expression/activation in IL-10-/- mice, leading to not only alleviation of ongoing colitis but also prevention/delay of disease onset.	Glyburide	0-9	NLR family, pyrin domain containing 3	Mus musculus	30-35
28404639-5	2017	Crown-like structures consisted of activated Kupffer cells (KCs) staining positive for NLRP3 and activated caspase 1, which surrounded and processed cholesterol crystal-containing remnant LDs of dead hepatocytes.	Cholesterol	149-160	NLR family, pyrin domain containing 3	Mus musculus	87-92
28404641-0	2017	NLRP3 inflammasome as a novel target for docosahexaenoic acid metabolites to abrogate glomerular injury.	Docosahexaenoic Acids	41-61	NLR family, pyrin domain containing 3	Mus musculus	0-5
28404641-4	2017	In vitro, confocal microscopy demonstrated that 17S-HDHA (100 nM) and RvD1 (60 nM) prevented Hcys-induced formation of NLRP3 inflammasomes, as shown by reduced colocalization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Homocysteine	93-97	NLR family, pyrin domain containing 3	Mus musculus	119-124
28404641-4	2017	In vitro, confocal microscopy demonstrated that 17S-HDHA (100 nM) and RvD1 (60 nM) prevented Hcys-induced formation of NLRP3 inflammasomes, as shown by reduced colocalization of NLRP3 with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) or caspase-1.	Homocysteine	93-97	NLR family, pyrin domain containing 3	Mus musculus	178-183
28404641-9	2017	It is concluded that inhibition of NLRP3 inflammasome activation is one of the important mechanisms mediating the beneficial action of RvD1 and 17S-HDHA on Hcys-induced podocyte injury and glomerular sclerosis.	Homocysteine	156-160	NLR family, pyrin domain containing 3	Mus musculus	35-40
33440489-0	2017	Targeting TNFalpha Ameliorated Cationic PAMAM Dendrimer-Induced Hepatotoxicity via Regulating NLRP3 Inflammasomes Pathway.	PAMAM dendrimer, ethylenediamine core, generation 0.0 solution	40-55	NLR family, pyrin domain containing 3	Mus musculus	94-99
28380426-0	2017	Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation.	Dextran Sulfate	40-62	NLR family, pyrin domain containing 3	Mus musculus	114-119
28493895-3	2017	Because the Na+/K+-ATPase is involved in inflammatory responses, we investigated the role of NLRP3 inflammasomes in the pathophysiology of cardiac glycoside-induced cardiac inflammation and dysfunction.	Glycosides	147-156	NLR family, pyrin domain containing 3	Mus musculus	93-98
28493895-7	2017	Furthermore, deficiency of NLRP3 inflammasome components, NLRP3 and caspase-1, also attenuated ouabain-induced cardiac dysfunction and inflammation.	Ouabain	95-102	NLR family, pyrin domain containing 3	Mus musculus	27-32
28493895-8	2017	In vitro experiments revealed that ouabain induced NLRP3 inflammasome activation as well as subsequent IL-1beta release from macrophages, and this activation was mediated by K+ efflux.	Ouabain	35-42	NLR family, pyrin domain containing 3	Mus musculus	51-56
28493895-9	2017	Our findings demonstrate that cardiac glycosides promote cardiac inflammation and dysfunction through NLRP3 inflammasomes and provide new insights into the mechanisms underlying the adverse effects of cardiac glycosides.	Glycosides	38-48	NLR family, pyrin domain containing 3	Mus musculus	102-107
28482444-10	2017	After stimulated by Pg LPS, mRNA and protein expression of IL-1beta (P&lt;0.01, P&lt;0.01) and NALP3 (P&lt;0.01, P&lt;0.01) significantly increased; but the expression of IL-1beta (P=0.002, P=0.027) and NALP3 (P&lt;0.01, P&lt;0.01) were decreased when pretreated with AC-YVAD-CMK.	ac-yvad	268-275	NLR family, pyrin domain containing 3	Mus musculus	95-100
28427239-2	2017	RESULTS: Up-regulation of Foxo3a restored autophagy flux and dampened the activation of the NLRP3 inflammasome in KCs stimulated with PA and LPS.	Protactinium	134-136	NLR family, pyrin domain containing 3	Mus musculus	92-97
28427239-6	2017	In addition, autophagy formation was restored, and activation of NLRP3 inflammasome was inhibited in KCs isolated from mice treated with Iturin A and fed with a HFD.	iturin A	137-145	NLR family, pyrin domain containing 3	Mus musculus	65-70
28415686-4	2017	CS could significantly inhibited HFD-induced lipid homeostasis, and inhibited inflammation in adipose tissue, as reflected by the decreased mRNA expression levels of inflammation-related genes and secretion of the chemokines/cytokines, inhibited the accumulation of adipose tissue macrophages (ATMs) and shifted their polarization from M1 to M2, suppressed HFD-induced expression of NLRP3 inflammasome component genes and decreased IL-1beta and Caspase-1 production in mice.	chikusetsu saponin IVa	0-2	NLR family, pyrin domain containing 3	Mus musculus	383-388
28415686-5	2017	Moreover, CS treatment also inhibited the activation of NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs).	chikusetsu saponin IVa	10-12	NLR family, pyrin domain containing 3	Mus musculus	56-61
28415686-6	2017	Meanwhile, CS treatment inhibited an NLRP3-induced ASC pyroptosome formation and lipopolysaccharide (LPS)-induced pyroptosis.	chikusetsu saponin IVa	11-13	NLR family, pyrin domain containing 3	Mus musculus	37-42
28415686-8	2017	Taking together, this study has revealed that CS effectively inhibits HFD-induced inflammation in adipose tissue of mice through inhibiting both NLRP3 inflammasome activation and NF-kappaB signaling.	chikusetsu saponin IVa	46-48	NLR family, pyrin domain containing 3	Mus musculus	145-150
33440489-7	2017	Moreover, suppression of NLRP3 inflammasomes by belnacasan could also protect against cationic PAMAM dendrimer-induced hepatotoxicity and TNFalpha-induced acute hepatotoxicity.	belnacasan	48-58	NLR family, pyrin domain containing 3	Mus musculus	25-30
33440489-7	2017	Moreover, suppression of NLRP3 inflammasomes by belnacasan could also protect against cationic PAMAM dendrimer-induced hepatotoxicity and TNFalpha-induced acute hepatotoxicity.	PAMAM dendrimer, ethylenediamine core, generation 0.0 solution	95-110	NLR family, pyrin domain containing 3	Mus musculus	25-30
33440489-9	2017	In general, these findings revealed that targeting TNFalpha could ameliorate cationic PAMAM dendrimer-induced hepatotoxicity via regulating NLRP3 inflammasome pathway, underscoring that TNFalpha antagonism by etanercept could be used as an effective pharmacological approach to control hepatotoxicity of cationic PAMAM dendrimers and thus providing novel therapeutic strategies for managing liver toxicity of nanomaterials via regulating inflammatory mediators.	PAMAM dendrimer, ethylenediamine core, generation 0.0 solution	86-101	NLR family, pyrin domain containing 3	Mus musculus	140-145
28558868-5	2017	Moreover, vaticaffinol markedly down-regulated renal protein levels of NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), and Caspase-1, resulting in the reduction of interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels in this animal model.	vaticaffinol	10-22	NLR family, pyrin domain containing 3	Mus musculus	71-90
28320097-8	2017	Of note, Asiatic acid reduces NOD-like receptor, pyrin domain containing-3 (NLRP3) inflammasome.	asiatic acid	9-21	NLR family, pyrin domain containing 3	Mus musculus	30-74
28320097-8	2017	Of note, Asiatic acid reduces NOD-like receptor, pyrin domain containing-3 (NLRP3) inflammasome.	asiatic acid	9-21	NLR family, pyrin domain containing 3	Mus musculus	76-81
28318352-0	2017	The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability.	Manganese	96-105	NLR family, pyrin domain containing 3	Mus musculus	12-17
28282788-0	2017	Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	37-42
28282788-0	2017	Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.	Palmitates	19-28	NLR family, pyrin domain containing 3	Mus musculus	37-42
28282788-0	2017	Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement.	Berberine	131-140	NLR family, pyrin domain containing 3	Mus musculus	37-42
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	37-46	NLR family, pyrin domain containing 3	Mus musculus	122-127
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Berberine	48-51	NLR family, pyrin domain containing 3	Mus musculus	122-127
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	saturated fatty acid palmitate	78-108	NLR family, pyrin domain containing 3	Mus musculus	122-127
28282788-3	2017	In the present study, we showed that berberine (BBR) significantly suppressed saturated fatty acid palmitate (PA)-induced NLRP3 inflammasome activation and interleukin-1beta (IL-1beta) release in macrophages, which was one of the most important mediators in the insulin sensitivity of adipose tissue.	Palmitates	110-112	NLR family, pyrin domain containing 3	Mus musculus	122-127
28558868-5	2017	Moreover, vaticaffinol markedly down-regulated renal protein levels of NOD-like receptor 3 (NLRP3), apoptosis-associated speck-like (ASC), and Caspase-1, resulting in the reduction of interleukin (IL)-1beta, IL-18, IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels in this animal model.	vaticaffinol	10-22	NLR family, pyrin domain containing 3	Mus musculus	92-97
28238167-8	2017	Treatment of 3xTg-AD mice with flavocoxid reduced: (1) learning and memory loss; (2) the increased eicosanoid production and the phosphorylation level of amyloid precursor protein (APP-pThr668), Abeta 1-42, p-tau (pThr181), pERK, and the activation of the NLRP3 inflammasome; (3) Abeta plaques; and (4) neuronal loss, compared to saline-treated animals.	flavocoxid	31-41	NLR family, pyrin domain containing 3	Mus musculus	256-261
27314460-5	2017	Oligodendrocytes of control pups showed expression of inflammasome components (NLRP3, ACS, and caspase-1) and their levels were increased by prenatal administration of dexamethasone (DEX), a synthetic GC.	Dexamethasone	168-181	NLR family, pyrin domain containing 3	Mus musculus	79-84
27314460-5	2017	Oligodendrocytes of control pups showed expression of inflammasome components (NLRP3, ACS, and caspase-1) and their levels were increased by prenatal administration of dexamethasone (DEX), a synthetic GC.	Dexamethasone	183-186	NLR family, pyrin domain containing 3	Mus musculus	79-84
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Reactive Oxygen Species	28-51	NLR family, pyrin domain containing 3	Mus musculus	110-137
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Reactive Oxygen Species	28-51	NLR family, pyrin domain containing 3	Mus musculus	139-144
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Reactive Oxygen Species	53-56	NLR family, pyrin domain containing 3	Mus musculus	110-137
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Reactive Oxygen Species	53-56	NLR family, pyrin domain containing 3	Mus musculus	139-144
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Homocysteine	207-219	NLR family, pyrin domain containing 3	Mus musculus	110-137
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Homocysteine	207-219	NLR family, pyrin domain containing 3	Mus musculus	139-144
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Homocysteine	221-225	NLR family, pyrin domain containing 3	Mus musculus	110-137
28193546-1	2017	NADPH oxidase (NOX)-derived reactive oxygen species (ROS) have been demonstrated to mediate the activation of NOD-like receptor protein 3 (NLRP3) inflammasomes in podocytes in response to elevated levels of homocysteine (Hcys).	Homocysteine	221-225	NLR family, pyrin domain containing 3	Mus musculus	139-144
28193546-3	2017	The present study tested whether the guanine nucleotide exchange factor Vav2 mediates Rac1-mediated NOX activation in response to elevated Hcys leading to NLRP3 inflammasome activation in podocytes and consequent glomerular injury.	Homocysteine	139-143	NLR family, pyrin domain containing 3	Mus musculus	155-160
28193546-10	2017	These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury.	Homocysteine	36-40	NLR family, pyrin domain containing 3	Mus musculus	138-143
28193546-10	2017	These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury.	Reactive Oxygen Species	107-110	NLR family, pyrin domain containing 3	Mus musculus	138-143
28188924-4	2017	Further investigation indicated that Daph significantly suppressed cytochrome c release and NLRP3 inflammasome activation and modulated apoptosis-related protein Bcl-2, Bax, and caspase-3 expression.	daphnetin	37-41	NLR family, pyrin domain containing 3	Mus musculus	92-97
28284330-7	2017	FPS-ZM1 and fasudil exerted their anti-inflammatory effects by downregulating inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), NLRP3 and nuclear translocation of nuclear factor kappa B (NF-kappaB) p65.	fasudil	12-19	NLR family, pyrin domain containing 3	Mus musculus	144-149
28167322-1	2017	BACKGROUND &amp; AIMS: NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in Non-alcoholic fatty liver disease (NAFLD).	Adenosine Monophosphate	12-15	NLR family, pyrin domain containing 3	Mus musculus	23-50
28167322-1	2017	BACKGROUND &amp; AIMS: NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in Non-alcoholic fatty liver disease (NAFLD).	Adenosine Monophosphate	12-15	NLR family, pyrin domain containing 3	Mus musculus	52-57
28167322-2	2017	We used the first small molecule NLRP3 inhibitor, MCC950, to test whether inflammasome blockade alters inflammatory recruitment and liver fibrosis in two murine models of steatohepatitis.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	50-56	NLR family, pyrin domain containing 3	Mus musculus	33-38
28167322-10	2017	This is potentially attributable to the blockade of cholesterol crystal-mediated NLRP3 activation in myeloid cells.	Cholesterol	52-63	NLR family, pyrin domain containing 3	Mus musculus	81-86
27706903-5	2017	RESULTS: Acetaminophen overdose resulted in a significant increase in serum transaminases, hepatocyte cell death, unfolded protein response activation, oxidative stress, NLRP3 inflammasome activation, caspase 1 and pro-inflammatory cytokine expressions.	Acetaminophen	9-22	NLR family, pyrin domain containing 3	Mus musculus	170-175
27706903-6	2017	Standard of care, N-acetylcysteine and, to a lesser extent, tauroursodeoxycholic treatment were associated with significantly lower transaminase levels, hepatocyte death, unfolded protein response activation, oxidative stress markers, caspase 1 expression and NLRP3 levels.	Acetylcysteine	18-34	NLR family, pyrin domain containing 3	Mus musculus	260-265
27706903-6	2017	Standard of care, N-acetylcysteine and, to a lesser extent, tauroursodeoxycholic treatment were associated with significantly lower transaminase levels, hepatocyte death, unfolded protein response activation, oxidative stress markers, caspase 1 expression and NLRP3 levels.	tauroursodeoxycholic	60-80	NLR family, pyrin domain containing 3	Mus musculus	260-265
27706903-7	2017	Importantly, the combination of N-acetylcysteine and tauroursodeoxycholic acid improved serum transaminase levels, reduced histopathological liver damage, UPR-activated CHOP, oxidative stress, caspase 1 expression, NLRP3 levels, IL-1beta levels and the expression of pro-inflammatory cytokines and this to a greater extend than N-acetylcysteine alone.	Acetylcysteine	32-48	NLR family, pyrin domain containing 3	Mus musculus	215-220
27706903-7	2017	Importantly, the combination of N-acetylcysteine and tauroursodeoxycholic acid improved serum transaminase levels, reduced histopathological liver damage, UPR-activated CHOP, oxidative stress, caspase 1 expression, NLRP3 levels, IL-1beta levels and the expression of pro-inflammatory cytokines and this to a greater extend than N-acetylcysteine alone.	ursodoxicoltaurine	53-78	NLR family, pyrin domain containing 3	Mus musculus	215-220
28350048-0	2017	Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-kappaB signaling and NLRP3 activation.	Silybin	0-7	NLR family, pyrin domain containing 3	Mus musculus	89-94
28350048-9	2017	Silybin exerts protective effects against lung injury by regulating NF-kappaB signaling and the NLRP3 inflammasome activation.	Silybin	0-7	NLR family, pyrin domain containing 3	Mus musculus	96-101
28404595-4	2017	In this study, we reveal that lysophosphatidylcholine (LPC), a molecule associated with neurodegeneration and demyelination, elicits NLRP3 and NLRC4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation.	Lysophosphatidylcholines	30-53	NLR family, pyrin domain containing 3	Mus musculus	133-138
28404595-4	2017	In this study, we reveal that lysophosphatidylcholine (LPC), a molecule associated with neurodegeneration and demyelination, elicits NLRP3 and NLRC4 inflammasome activation in microglia and astrocytes, which are central players in neuroinflammation.	Lysophosphatidylcholines	55-58	NLR family, pyrin domain containing 3	Mus musculus	133-138
28376889-0	2017	Grape seed-derived procyanidins alleviate gout pain via NLRP3 inflammasome suppression.	Proanthocyanidins	19-31	NLR family, pyrin domain containing 3	Mus musculus	56-61
28380377-3	2017	Here, we show that bile acids are danger-associated molecular patterns (DAMPs) that can activate both signal 1 and 2 of the NLRP3 inflammasome in inflammatory macrophages.	Bile Acids and Salts	19-29	NLR family, pyrin domain containing 3	Mus musculus	124-129
28380377-4	2017	Mechanistically, bile acids induce a prolonged calcium influx and activate the NLRP3 inflammasome synergistically with ATP.	Bile Acids and Salts	17-27	NLR family, pyrin domain containing 3	Mus musculus	79-84
28380377-8	2017	These findings suggest that bile acids and FXR play pivotal roles in sepsis via controlling the NLRP3 inflammasome, and that targeting FXR may represent a therapeutic strategy for cholestasis-associated sepsis.	Bile Acids and Salts	28-38	NLR family, pyrin domain containing 3	Mus musculus	96-101
28376889-3	2017	The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production.	Uric Acid	14-30	NLR family, pyrin domain containing 3	Mus musculus	126-131
28376889-3	2017	The uptake of monosodium urate (MSU) crystals by macrophages can lead to activation of NOD-like receptors containing a PYD 3 (NLRP3) inflammasome, thus accelerating interleukin (IL)-1beta production.	Uric Acid	32-35	NLR family, pyrin domain containing 3	Mus musculus	126-131
28376889-4	2017	Reactive oxygen species (ROS) promoted development of the inflammatory process through NLRP3 inflammasome.	Reactive Oxygen Species	0-23	NLR family, pyrin domain containing 3	Mus musculus	87-92
28376889-4	2017	Reactive oxygen species (ROS) promoted development of the inflammatory process through NLRP3 inflammasome.	Reactive Oxygen Species	25-28	NLR family, pyrin domain containing 3	Mus musculus	87-92
28376889-12	2017	Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta.	Proanthocyanidins	0-12	NLR family, pyrin domain containing 3	Mus musculus	58-63
28376889-12	2017	Procyanidins also inhibited MSU-induced activation of the NLRP3 inflammasome and increase of IL-1beta.	Uric Acid	28-31	NLR family, pyrin domain containing 3	Mus musculus	58-63
28376889-14	2017	CONCLUSIONS: Suppression of the NLRP3 inflammasome in macrophages contributes to the amelioration of gout pain by procyanidins.	Proanthocyanidins	114-126	NLR family, pyrin domain containing 3	Mus musculus	32-37
28052869-9	2017	In the mice with NLRP3 gene deletion, Aldo-induced downregulation of nephrin and podocin, podocyte foot processes, and albuminuria was remarkably improved, indicating an amelioration of podocyte injury.	Aldosterone	38-42	NLR family, pyrin domain containing 3	Mus musculus	17-22
28213267-3	2017	Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-kappaB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS).	ferulic acid	126-138	NLR family, pyrin domain containing 3	Mus musculus	343-348
28202418-0	2017	ROS/TXNIP pathway contributes to thrombin induced NLRP3 inflammasome activation and cell apoptosis in microglia.	Reactive Oxygen Species	0-3	NLR family, pyrin domain containing 3	Mus musculus	50-55
28202418-8	2017	Thrombin activates ROS/TXNIP/NLRP3 signaling in BV2 cells, which may indicate a mechanism that pro-inflammatory and pro-apoptotic contributes to the development of ICH.	Reactive Oxygen Species	19-22	NLR family, pyrin domain containing 3	Mus musculus	29-34
28219839-0	2017	Sinigrin inhibits production of inflammatory mediators by suppressing NF-kappaB/MAPK pathways or NLRP3 inflammasome activation in macrophages.	sinigrin	0-8	NLR family, pyrin domain containing 3	Mus musculus	97-102
28219839-6	2017	Treatment with sinigrin decreased IL-1beta and IL-18 production and concurrently suppressed NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 expression in LPS/ATP-stimulated cells, suggesting that the blocking of NLRP3 inflammasome activation prevented the production of both cytokines.	sinigrin	15-23	NLR family, pyrin domain containing 3	Mus musculus	92-97
28447181-0	2017	SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes.	dapagliflozin	23-36	NLR family, pyrin domain containing 3	Mus musculus	67-72
28447181-2	2017	PURPOSE: We assessed whether (1) dapagliflozin (Dapa, an SGLT2-inhibitor) attenuates the deterioration of heart function Nlrp3 and inflammasome activation in diabetic mice.	dapagliflozin	33-46	NLR family, pyrin domain containing 3	Mus musculus	121-126
28447181-2	2017	PURPOSE: We assessed whether (1) dapagliflozin (Dapa, an SGLT2-inhibitor) attenuates the deterioration of heart function Nlrp3 and inflammasome activation in diabetic mice.	dapagliflozin	48-52	NLR family, pyrin domain containing 3	Mus musculus	121-126
28447181-15	2017	This in vitro study showed that NALP3, ASC, IL-1beta, and caspase-1 mRNA levels were higher in the BTBR cardiofibroblasts and attenuated with Dapa.	dapagliflozin	142-146	NLR family, pyrin domain containing 3	Mus musculus	32-37
28219839-6	2017	Treatment with sinigrin decreased IL-1beta and IL-18 production and concurrently suppressed NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 expression in LPS/ATP-stimulated cells, suggesting that the blocking of NLRP3 inflammasome activation prevented the production of both cytokines.	sinigrin	15-23	NLR family, pyrin domain containing 3	Mus musculus	272-277
28219839-7	2017	Collectively, these results suggest that sinigrin has immunomodulatory effects by suppressing the production of inflammatory mediators, possibly by inhibiting the NF-kappaB/MAPK pathways or NLRP3 inflammasome activation.	sinigrin	41-49	NLR family, pyrin domain containing 3	Mus musculus	190-195
28213267-5	2017	Then, we found that CUMS significantly caused interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) up-regulation, microglia, NF-kappaB signaling and NLRP3 inflammasome activation in the prefrontal cortex.	cums	20-24	NLR family, pyrin domain containing 3	Mus musculus	191-196
28099758-0	2017	Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	74-79
28189916-0	2017	Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.	Fructose	45-53	NLR family, pyrin domain containing 3	Mus musculus	134-139
28189916-7	2017	In addition, we found inhibition of Keap1/Nrf2 antioxidant signaling and more robust stimulation of the Nlrp3 inflammasome pathway in the livers of HFRT-fed mice when compared with HFAT-fed mice, which is consistent with the recent finding that palmitate and SREBP1c are implicated in hepatic oxidative stress and inflammation.	Palmitates	245-254	NLR family, pyrin domain containing 3	Mus musculus	104-109
28189916-9	2017	Thus, we hypothesize an amplifying loop among lipogenesis, palmitate, Nrf2 and Nlrp3 that leads to a higher risk of NAFLD progression to NASH in a high-fructose diet compared to a high-saturated fat intake.	Fructose	152-160	NLR family, pyrin domain containing 3	Mus musculus	79-84
28189916-9	2017	Thus, we hypothesize an amplifying loop among lipogenesis, palmitate, Nrf2 and Nlrp3 that leads to a higher risk of NAFLD progression to NASH in a high-fructose diet compared to a high-saturated fat intake.	saturated fat	185-198	NLR family, pyrin domain containing 3	Mus musculus	79-84
28099758-0	2017	Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.	Cadmium	21-28	NLR family, pyrin domain containing 3	Mus musculus	74-79
28099758-7	2017	In addition, we showed that Cd triggered an inflammatory cell death, which is mediated by the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome.	Cadmium	28-30	NLR family, pyrin domain containing 3	Mus musculus	139-144
28099758-8	2017	Moreover, melatonin treatment significantly alleviated Cd-induced liver injury by decreasing serum ALT/AST levels, suppressing pro-inflammatory cytokine production, inhibiting NLRP3 inflammasome activation, ameliorating oxidative stress, and attenuating hepatocyte death.	Melatonin	10-19	NLR family, pyrin domain containing 3	Mus musculus	176-181
28099758-8	2017	Moreover, melatonin treatment significantly alleviated Cd-induced liver injury by decreasing serum ALT/AST levels, suppressing pro-inflammatory cytokine production, inhibiting NLRP3 inflammasome activation, ameliorating oxidative stress, and attenuating hepatocyte death.	Cadmium	55-57	NLR family, pyrin domain containing 3	Mus musculus	176-181
28099758-9	2017	Most importantly, melatonin markedly abrogated Cd-induced TXNIP overexpression and decreased the interaction between TXNIP and NLRP3 in vivo and in vitro.	Melatonin	18-27	NLR family, pyrin domain containing 3	Mus musculus	127-132
28099758-11	2017	Collectively, our results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 inflammasome pathway.	Melatonin	39-48	NLR family, pyrin domain containing 3	Mus musculus	155-160
28099758-11	2017	Collectively, our results suggest that melatonin confers protection against Cd-induced liver inflammation and hepatocyte death via inhibition of the TXNIP-NLRP3 inflammasome pathway.	Cadmium	76-78	NLR family, pyrin domain containing 3	Mus musculus	155-160
28202417-0	2017	Triptolide attenuates pressure overload-induced myocardial remodeling in mice via the inhibition of NLRP3 inflammasome expression.	triptolide	0-10	NLR family, pyrin domain containing 3	Mus musculus	100-105
28093255-11	2017	The knockout of NLRP3 gene inhibited CUMS-induced activation of the MAPK pathway.	cums	37-41	NLR family, pyrin domain containing 3	Mus musculus	16-21
28093255-13	2017	CONCLUSIONS: These data further proved that the NLRP3 inflammasome mediated CUMS-induced depression-like behavior.	cums	76-80	NLR family, pyrin domain containing 3	Mus musculus	48-53
28093255-14	2017	The NLRP3 inflammasome regulated CUMS-induced MAPK pathway and NF-kappaB protein complex activation in depression mouse model.	cums	33-37	NLR family, pyrin domain containing 3	Mus musculus	4-9
28202417-8	2017	Our study demonstrated that the protective effect of triptolide against pressure overload in the heart may act by inhibiting the NLRP3 inflammasome-induced inflammatory response and activating the profibrotic pathway.	triptolide	53-63	NLR family, pyrin domain containing 3	Mus musculus	129-134
28202417-7	2017	Triptolide treatment attenuated TAC-induced myocardial remodeling, improved cardiac diastolic and systolic function, inhibited the NLRP3 inflammasome and downstream inflammatory mediators (IL-1beta, IL-18, MCP-1, VCAM-1), activated the profibrotic TGF-beta1 pathway, and suppressed macrophage infiltration in a dose-dependent manner.	triptolide	0-10	NLR family, pyrin domain containing 3	Mus musculus	131-136
28337127-2	2017	The nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome, a subcellular multiprotein complex that is abundantly expressed in the central nervous system (CNS), can sense and be activated by a wide range of exogenous and endogenous stimuli such as microbes, aggregated and misfolded proteins, and adenosine triphosphate, which results in activation of caspase-1.	Adenosine Triphosphate	358-380	NLR family, pyrin domain containing 3	Mus musculus	100-105
28303894-8	2017	MK-801 also decreased the expression of pro-inflammatory cytokines, and inhibited I-kappaB degradation, ROS generation and NLRP3 inflammasome expression in beta-cells exposed to high-glucose.	Dizocilpine Maleate	0-6	NLR family, pyrin domain containing 3	Mus musculus	123-128
28273882-0	2017	Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn.	Butyrates	44-52	NLR family, pyrin domain containing 3	Mus musculus	14-19
28273882-7	2017	Treatment with NLRP3 inhibitors using NaB and HBA preserved corneal clarity and decreased NLRP3, caspase-1, and IL-1beta mRNA transcripts, as well as NLRP3 protein expression on post-injury compared to BSS-treated corneas.	nab	38-41	NLR family, pyrin domain containing 3	Mus musculus	15-20
28273882-7	2017	Treatment with NLRP3 inhibitors using NaB and HBA preserved corneal clarity and decreased NLRP3, caspase-1, and IL-1beta mRNA transcripts, as well as NLRP3 protein expression on post-injury compared to BSS-treated corneas.	nab	38-41	NLR family, pyrin domain containing 3	Mus musculus	90-95
28273882-7	2017	Treatment with NLRP3 inhibitors using NaB and HBA preserved corneal clarity and decreased NLRP3, caspase-1, and IL-1beta mRNA transcripts, as well as NLRP3 protein expression on post-injury compared to BSS-treated corneas.	nab	38-41	NLR family, pyrin domain containing 3	Mus musculus	90-95
28096316-0	2017	BAY 11-7082 inhibits the NF-kappaB and NLRP3 inflammasome pathways and protects against IMQ-induced psoriasis.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	NLR family, pyrin domain containing 3	Mus musculus	39-44
28168403-0	2017	Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts.	Carbon Monoxide	0-15	NLR family, pyrin domain containing 3	Mus musculus	100-105
28168403-8	2017	Treatment of CF with CORM-3 before ATP prevented ATP-induced activation of the NLRP3 inflammasome.	Adenosine Triphosphate	49-52	NLR family, pyrin domain containing 3	Mus musculus	79-84
28168403-9	2017	Challenging CF with LPS/ATP promoted NLRP3 interactions with adaptor ASC (apoptosis-associated speck-like protein containing a caspase-recruitment domain), which was prevented by CORM-3.	Adenosine Triphosphate	24-27	NLR family, pyrin domain containing 3	Mus musculus	37-42
28096316-1	2017	BAY 11-7082 antagonizes I-kappaB kinase-beta preventing nuclear translocation of nuclear factor-kappaB (NF-kappaB); it also inhibits NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	NLR family, pyrin domain containing 3	Mus musculus	186-191
28096316-11	2017	BAY 11-7082 reduced pNF-kappaB, NLRP3, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta expression, blunted the phosphorylation of signal transducer and activators of transcription 3 (STAT3) and decreased IL-23 levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	NLR family, pyrin domain containing 3	Mus musculus	32-37
28096316-13	2017	NLRP3 KO animals showed a reduced total histological score but persistent mild acanthosis, dermal thickness and expression of pNF-kappaB and pSTAT3, following IMQ application.	Imiquimod	159-162	NLR family, pyrin domain containing 3	Mus musculus	0-5
28096316-14	2017	Our data suggest that BAY 11-7082 might represent an interesting approach for the management of psoriasis-like dermatitis depending on the dual inhibition of NF-kappaB and NLRP3.	3-(4-methylphenylsulfonyl)-2-propenenitrile	22-33	NLR family, pyrin domain containing 3	Mus musculus	172-177
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Reactive Oxygen Species	181-204	NLR family, pyrin domain containing 3	Mus musculus	248-253
28132925-6	2017	Furthermore, both NADPH and apocynin suppressed the expression of inflammasome proteins including NLRP3 ASC, caspase-1, interleukin (IL)-1beta and IL-18 in the ischemic cortex as revealed by Western blot analysis and immunofluorescence.	NADP	18-23	NLR family, pyrin domain containing 3	Mus musculus	98-103
28092375-6	2017	IL-1beta and insulin increased the uptake of glucose into macrophages, and insulin reinforced a pro-inflammatory pattern via the insulin receptor, glucose metabolism, production of reactive oxygen species, and secretion of IL-1beta mediated by the NLRP3 inflammasome.	Glucose	45-52	NLR family, pyrin domain containing 3	Mus musculus	248-253
28289409-5	2017	Diabetic mice also showed increased positive caspase-1 macrophages in the PLNs, which were decreased in NLRP3-/- mice, but not in ASC-/- mice, after STZ treatment.	Streptozocin	149-152	NLR family, pyrin domain containing 3	Mus musculus	104-109
28126413-4	2017	Bafilomycin A1 treatment of particle-exposed macrophages also resulted in decreased active cathepsin L in the cytosol, a surrogate measure for leaked cathepsin B, which was associated with less NLRP3 inflammasome activity.	bafilomycin	0-11	NLR family, pyrin domain containing 3	Mus musculus	194-199
28289409-3	2017	Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice.	Streptozocin	148-162	NLR family, pyrin domain containing 3	Mus musculus	40-45
28289409-12	2017	Overall, our results demonstrate that mDNA-mediated NLRP3 activation triggers caspase-1-dependent IL-1beta production and contributes to pathogenic cellular responses during the development of STZ-induced T1D.	Streptozocin	193-196	NLR family, pyrin domain containing 3	Mus musculus	52-57
28289409-3	2017	Similar increases in gene expression of NLRP3, apoptosis associated speck like protein (ASC) and pro-IL-1beta were induced by multiple low doses of streptozotocin (STZ) in C57BL/6 mice.	Streptozocin	164-167	NLR family, pyrin domain containing 3	Mus musculus	40-45
27923741-6	2017	These effects were blocked by the NLRP3 inflammasome inhibitor Ac-Tyr-Val-Ala-Asp-chloromethylketone.	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketone	63-100	NLR family, pyrin domain containing 3	Mus musculus	34-39
28011393-8	2017	Importantly, we found that AS-IV suppressed NLRP3 inflammasome activation by controlling ROS production.	Reactive Oxygen Species	89-92	NLR family, pyrin domain containing 3	Mus musculus	44-49
28265343-11	2017	Palmitate upregulated NLRP3 and IL1beta expression in primary Muller cells isolated from wild type.	Palmitates	0-9	NLR family, pyrin domain containing 3	Mus musculus	22-27
28265343-12	2017	However, using primary Muller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1beta.	Palmitates	107-116	NLR family, pyrin domain containing 3	Mus musculus	138-143
27912077-10	2017	In vivo, the DDC-stimulated number of cytokeratin-19-positive cells in the liver of wild-type animals was slightly reduced in Nlrp3-/- mice, and expression of E-cadherin was reestablished.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	13-16	NLR family, pyrin domain containing 3	Mus musculus	126-131
27730320-5	2017	Together, these results suggest that (i) NLRP3 inflammasome and local IL-1beta(+)F4/80(+)Ly6C(+) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy and (ii) identified MCC950 specific inhibitor of the NLRP3 inflammasome with promising therapeutic potential for the treatment of VCP-associated myopathy.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	196-202	NLR family, pyrin domain containing 3	Mus musculus	41-46
28117341-4	2017	These results strongly suggest that NLRP3 inflammasome serves as a key player in the pathogenesis of IgAN partly through activation of T cells and mitochondrial ROS production and that a local, kidney-targeting suppression of NLRP3 be a therapeutic strategy for IgAN.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	36-41
28031338-8	2017	Intriguingly, following CLP, Nlrp3-/- peritoneal cells (primarily neutrophils) demonstrate decreased autophagy, augmented phagocytosis, and enhanced scavenger receptor (macrophage receptor with collagenous structure) and mannose-binding leptin expression.	Mannose	221-228	NLR family, pyrin domain containing 3	Mus musculus	29-34
28039299-7	2017	Nlrp3-R258W mutant mice exhibited significantly higher mortality upon pristane challenge.	pristane	70-78	NLR family, pyrin domain containing 3	Mus musculus	0-5
28167912-7	2017	Mechanistic studies revealed that C5a most likely increased NLRP3 inflammasome activation via production of reactive oxygen species (ROS), and not through increased transcription of inflammasome components.	Reactive Oxygen Species	108-131	NLR family, pyrin domain containing 3	Mus musculus	60-65
28167912-7	2017	Mechanistic studies revealed that C5a most likely increased NLRP3 inflammasome activation via production of reactive oxygen species (ROS), and not through increased transcription of inflammasome components.	Reactive Oxygen Species	133-136	NLR family, pyrin domain containing 3	Mus musculus	60-65
28167912-8	2017	Therefore we conclude that C5a generated upon MSU-induced complement activation increases neutrophil recruitment in vivo by promoting IL-1 production via the generation of ROS, which activate the NLRP3 inflammasome.	Reactive Oxygen Species	172-175	NLR family, pyrin domain containing 3	Mus musculus	196-201
28117341-4	2017	These results strongly suggest that NLRP3 inflammasome serves as a key player in the pathogenesis of IgAN partly through activation of T cells and mitochondrial ROS production and that a local, kidney-targeting suppression of NLRP3 be a therapeutic strategy for IgAN.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	226-231
27308893-0	2017	Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming.	Reactive Oxygen Species	98-121	NLR family, pyrin domain containing 3	Mus musculus	56-61
27797173-0	2017	Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Abeta-Mediated Microglial Inflammation.	dipeptidyl vinyl sulfone	0-24	NLR family, pyrin domain containing 3	Mus musculus	67-72
27913620-5	2017	We have also shown that H7N9 and A/Puerto Rico/H1N1 (PR8)PB1-F2 peptide treatment induces significant mitochondrial reactive oxygen production, which contributes to NLRP3 activation.	reactive oxygen	116-131	NLR family, pyrin domain containing 3	Mus musculus	165-170
27913620-6	2017	Importantly, treatment of cells or mice with the specific NLRP3 inhibitor MCC950 significantly reduces IL-1beta maturation, lung cellular recruitment, and cytokine production.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	74-80	NLR family, pyrin domain containing 3	Mus musculus	58-63
27308893-0	2017	Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming.	Reactive Oxygen Species	98-121	NLR family, pyrin domain containing 3	Mus musculus	130-135
27308893-5	2017	Compared with normal cells, Nrf2-deficient cells showed upregulated cleaved caspase-1, which were attributed to the increased transcription of NLRP3 caused by excess reactive oxygen species (ROS).	Reactive Oxygen Species	166-189	NLR family, pyrin domain containing 3	Mus musculus	143-148
27308893-5	2017	Compared with normal cells, Nrf2-deficient cells showed upregulated cleaved caspase-1, which were attributed to the increased transcription of NLRP3 caused by excess reactive oxygen species (ROS).	Reactive Oxygen Species	191-194	NLR family, pyrin domain containing 3	Mus musculus	143-148
27308893-6	2017	Furthermore, priming of the NLRP3 inflammasome was sensitive to the exogenous ROS levels induced by H2O2 or rotenone.	Reactive Oxygen Species	78-81	NLR family, pyrin domain containing 3	Mus musculus	28-33
27308893-6	2017	Furthermore, priming of the NLRP3 inflammasome was sensitive to the exogenous ROS levels induced by H2O2 or rotenone.	Hydrogen Peroxide	100-104	NLR family, pyrin domain containing 3	Mus musculus	28-33
27308893-6	2017	Furthermore, priming of the NLRP3 inflammasome was sensitive to the exogenous ROS levels induced by H2O2 or rotenone.	Rotenone	108-116	NLR family, pyrin domain containing 3	Mus musculus	28-33
27308893-7	2017	Combined with adenosine triphosphate, rotenone triggered higher activity of the NLRP3 inflammasome compared with lipopolysaccharide, suggesting that ROS promoted the priming step.	Adenosine Triphosphate	14-36	NLR family, pyrin domain containing 3	Mus musculus	80-85
27308893-7	2017	Combined with adenosine triphosphate, rotenone triggered higher activity of the NLRP3 inflammasome compared with lipopolysaccharide, suggesting that ROS promoted the priming step.	Rotenone	38-46	NLR family, pyrin domain containing 3	Mus musculus	80-85
27308893-7	2017	Combined with adenosine triphosphate, rotenone triggered higher activity of the NLRP3 inflammasome compared with lipopolysaccharide, suggesting that ROS promoted the priming step.	Reactive Oxygen Species	149-152	NLR family, pyrin domain containing 3	Mus musculus	80-85
27308893-10	2017	INNOVATION: We elucidated the effects and possible mechanisms of Nrf2 activation-induced NQO1 expression on NLRP3 inflammasome inactivation and established a novel regulatory role of the Nrf2 pathway in ROS-induced NLRP3 priming.	Reactive Oxygen Species	203-206	NLR family, pyrin domain containing 3	Mus musculus	215-220
26996064-5	2017	We then used the bacterial toxin nigericin and a common product released from necrotic cells, ATP, as prototypical microbial and sterile signal 2 stimuli, respectively, to trigger the assembly of the NLRP3 inflammasome complex in mouse and human macrophages.	Nigericin	33-42	NLR family, pyrin domain containing 3	Mus musculus	200-205
28194406-0	2017	Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	57-62
28194406-7	2017	Additionally, curcumin treatment was associated with significant reductions in mature interleukin-1beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells exposed to high glucose concentration.	Curcumin	14-22	NLR family, pyrin domain containing 3	Mus musculus	128-133
28194406-8	2017	In summary, curcumin, a potent antifibrotic agent, is a promising treatment for DN, and its renoprotective effects appear to be mediated by the inhibition of NLRP3 inflammasome activity.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	158-163
26996064-5	2017	We then used the bacterial toxin nigericin and a common product released from necrotic cells, ATP, as prototypical microbial and sterile signal 2 stimuli, respectively, to trigger the assembly of the NLRP3 inflammasome complex in mouse and human macrophages.	Adenosine Triphosphate	94-97	NLR family, pyrin domain containing 3	Mus musculus	200-205
28490015-10	2017	Importantly, knockdown of SIRT1 reversed the inhibitory effect of SDS on NLRP3 inflammasome activation.	rhodioloside	66-69	NLR family, pyrin domain containing 3	Mus musculus	73-78
28490015-11	2017	CONCLUSIONS: Taken together, these findings indicate that SDS may confer protection against ventilation induced lung injury via SIRT1-de-pendent inhibition of NLRP3 inflammasome activation.	rhodioloside	58-61	NLR family, pyrin domain containing 3	Mus musculus	159-164
28490015-0	2017	Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	89-94
29132140-9	2017	Moreover, SS-31 treatment attenuated reactive oxygen species levels, reversed mitochondrial dysfunction and inhibited NLRP3 inflammasome activation.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	10-15	NLR family, pyrin domain containing 3	Mus musculus	118-123
28490015-8	2017	SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase-1 cleavage as well as interleukin (IL)-1beta secretion both in vivo and in vitro.	rhodioloside	0-3	NLR family, pyrin domain containing 3	Mus musculus	42-47
28873369-8	2017	In addition, the activation of NLRP3 inflammasome was restrained by Dex both in lung tissue in vivo and RAW264.7 cells in vitro.	Dexmedetomidine	68-71	NLR family, pyrin domain containing 3	Mus musculus	31-36
29130962-6	2017	RESULTS: TMAO treatment significantly increased the colocalization of NLRP3 with Asc or NLRP3 with caspase-1, caspase-1 activity, IL-1beta production, cell permeability in carotid artery endothelial cells (CAECs) compared to control cells.	trimethyloxamine	9-13	NLR family, pyrin domain containing 3	Mus musculus	88-93
29130962-7	2017	Pretreatment with caspase-1 inhibitor, WEHD or Nlrp3 siRNA abolished the TMAO-induced inflammasome formation, activation and cell permeability in these cells.	trimethyloxamine	73-77	NLR family, pyrin domain containing 3	Mus musculus	47-52
29130962-8	2017	In addition, we explored the mechanisms by which TMAO activates NLRP3 inflammasomes.	trimethyloxamine	49-53	NLR family, pyrin domain containing 3	Mus musculus	64-69
29130962-9	2017	TMAO-induced the activation of NLRP3 inflammasomes was associated with both redox regulation and lysosomal dysfunction.	trimethyloxamine	0-4	NLR family, pyrin domain containing 3	Mus musculus	31-36
29130962-10	2017	In animal experiments, direct infusion of TMAO in mice with partially ligated carotid artery were found to have increased NLRP3 inflammasome formation and IL-1beta production in the intima of wild type mice.	trimethyloxamine	42-46	NLR family, pyrin domain containing 3	Mus musculus	122-127
29130962-11	2017	CONCLUSION: The formation and activation of NLRP3 inflammasomes by TMAO may be an important initiating mechanism to turn on the endothelial inflammatory response leading to endothelial dysfunction.	trimethyloxamine	67-71	NLR family, pyrin domain containing 3	Mus musculus	44-49
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Fenofibrate	52-63	NLR family, pyrin domain containing 3	Mus musculus	158-185
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Fenofibrate	52-63	NLR family, pyrin domain containing 3	Mus musculus	187-192
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Streptozocin	210-224	NLR family, pyrin domain containing 3	Mus musculus	158-185
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Streptozocin	210-224	NLR family, pyrin domain containing 3	Mus musculus	187-192
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Streptozocin	226-229	NLR family, pyrin domain containing 3	Mus musculus	158-185
28817808-3	2017	The current study aimed to test our hypothesis that fenofibrate stimulates angiogenesis and restores endothelial precursor cell (EPC) function via inhibiting Nod-like receptor protein 3 (NLRP3) inflammasome in streptozotocin (STZ)-induced diabetic mice.	Streptozocin	226-229	NLR family, pyrin domain containing 3	Mus musculus	187-192
28817808-11	2017	Furthermore, fenofibrate deregulated the activity of NLRP3 inflammasome by reducing TXNIP, NLRP3 and caspase-1 expression in EPCs of diabetic mice.	Fenofibrate	13-24	NLR family, pyrin domain containing 3	Mus musculus	53-58
28817808-11	2017	Furthermore, fenofibrate deregulated the activity of NLRP3 inflammasome by reducing TXNIP, NLRP3 and caspase-1 expression in EPCs of diabetic mice.	Fenofibrate	13-24	NLR family, pyrin domain containing 3	Mus musculus	91-96
28817808-12	2017	In vitro, fenofibrate prevented high glucose induced EPC dysfunction, deregulated NLRP3 inflammasome activity.	Fenofibrate	10-21	NLR family, pyrin domain containing 3	Mus musculus	82-87
28817808-14	2017	CONCLUSION: Fenofibrate can accelerate wound healing in diabetic mice, which at least in part was mediated by improving the impaired EPC function via a NLRP3 inflammasome pathway, suggesting the significance of PPARalpha agonists in the treatment of diabetes.	Fenofibrate	12-23	NLR family, pyrin domain containing 3	Mus musculus	152-157
29130962-0	2017	Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction.	trimethyloxamine	0-22	NLR family, pyrin domain containing 3	Mus musculus	34-39
29130962-3	2017	The present study tested whether TMAO induces NLRP3 inflammasome formation and activation and thereby contributes to endothelial injury initiating atherogenesis.	trimethyloxamine	33-37	NLR family, pyrin domain containing 3	Mus musculus	46-51
29130962-6	2017	RESULTS: TMAO treatment significantly increased the colocalization of NLRP3 with Asc or NLRP3 with caspase-1, caspase-1 activity, IL-1beta production, cell permeability in carotid artery endothelial cells (CAECs) compared to control cells.	trimethyloxamine	9-13	NLR family, pyrin domain containing 3	Mus musculus	70-75
29435463-5	2017	Principal coordinate analysis clearly separated controls, STZ, and NLRP3-KO STZ mice.	Streptozocin	76-79	NLR family, pyrin domain containing 3	Mus musculus	67-72
29169180-2	2017	We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome.	Aldosterone	28-39	NLR family, pyrin domain containing 3	Mus musculus	172-177
29169180-2	2017	We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome.	Aldosterone	28-32	NLR family, pyrin domain containing 3	Mus musculus	172-177
29169180-2	2017	We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome.	Reactive Oxygen Species	113-136	NLR family, pyrin domain containing 3	Mus musculus	172-177
29169180-2	2017	We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome.	mtros	138-143	NLR family, pyrin domain containing 3	Mus musculus	172-177
29169180-9	2017	RESULTS: Compared with control mice, Aldo-infused mice showed impaired renal function, increased mtROS production and MtD, Nlrp3 inflammasome activation, and elevated ERS.	Aldosterone	37-41	NLR family, pyrin domain containing 3	Mus musculus	123-128
27930969-3	2017	In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of rhapontin (100mg/kg) significantly attenuated colonic pathological damage and remarkably inhibited infiltration by inflammatory cells, myeloperoxidase (MPO) activity, NLRP3 inflammasome activation and SIRT1 expression in the colon.	rhapontin	78-87	NLR family, pyrin domain containing 3	Mus musculus	245-250
29435463-7	2017	When compared to the WT STZ group, the NLRP3-KO STZ group showed a significant decrease in the Firmicutes : Bacteroidetes ratio.	Streptozocin	24-27	NLR family, pyrin domain containing 3	Mus musculus	39-44
29435463-7	2017	When compared to the WT STZ group, the NLRP3-KO STZ group showed a significant decrease in the Firmicutes : Bacteroidetes ratio.	Streptozocin	48-51	NLR family, pyrin domain containing 3	Mus musculus	39-44
28004759-9	2016	LR12 also reduced the expression of NLRP3 and caspase-1 p10 protein, and secretion of the IL-1beta, inhibited activation of the NLRP3 inflammasome by decreasing ROS.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	128-133
27256568-0	2017	Oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages.	Phosphatidylcholines	9-28	NLR family, pyrin domain containing 3	Mus musculus	55-60
27256568-4	2017	In this study, we investigated whether oxidized phosphatidylcholine induces the activation of NLRP3 inflammasome in macrophages, leading to the secretion of IL-1beta.	Phosphatidylcholines	48-67	NLR family, pyrin domain containing 3	Mus musculus	94-99
27256568-9	2017	Our results demonstrate that endogenously produced oxidized phosphatidylcholines such as POVPC induce the activation of NLRP3 inflammasome, leading to the production of IL-1beta in macrophages.	Phosphatidylcholines	60-80	NLR family, pyrin domain containing 3	Mus musculus	120-125
28321151-0	2017	The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock.	Chloroquine	17-28	NLR family, pyrin domain containing 3	Mus musculus	52-57
28321151-3	2017	In this study, we investigated whether CQ suppresses NLRP3 inflammasome activation and thereby confers protection against murine endotoxic shock.	Chloroquine	39-41	NLR family, pyrin domain containing 3	Mus musculus	53-58
28321151-4	2017	CQ attenuated NF-kappaB and MAPK activation and prohibited expression of IL-1beta, IL-18, and Nlrp3 in LPS treated murine bone marrow-derived macrophages (BMDMs), demonstrating its inhibitory effect on the priming signal of NLRP3 activation.	Chloroquine	0-2	NLR family, pyrin domain containing 3	Mus musculus	94-99
28321151-4	2017	CQ attenuated NF-kappaB and MAPK activation and prohibited expression of IL-1beta, IL-18, and Nlrp3 in LPS treated murine bone marrow-derived macrophages (BMDMs), demonstrating its inhibitory effect on the priming signal of NLRP3 activation.	Chloroquine	0-2	NLR family, pyrin domain containing 3	Mus musculus	224-229
28321151-5	2017	Then, CQ was shown to inhibit caspase-1 activation and ASC specks formation in BMDMs, which indicates that CQ also suppresses inflammasome assembly, the second signal for NLRP3 inflammasome activation.	Chloroquine	6-8	NLR family, pyrin domain containing 3	Mus musculus	171-176
28321151-8	2017	Overall, our results demonstrate a new role of CQ that facilitates negative regulation on NLRP3 inflammasome, which thereby confers protection against lethal endotoxic shock.	Chloroquine	47-49	NLR family, pyrin domain containing 3	Mus musculus	90-95
27280937-0	2017	Astagalus Polysaccharide Attenuates Murine Colitis through Inhibiton of the NLRP3 Inflammasome.	astagalus polysaccharide	0-24	NLR family, pyrin domain containing 3	Mus musculus	76-81
29075366-0	2017	The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.	Lignans	14-20	NLR family, pyrin domain containing 3	Mus musculus	80-85
29075366-0	2017	The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.	secoisolariciresinol diglucoside	21-53	NLR family, pyrin domain containing 3	Mus musculus	80-85
29075366-4	2017	RESULTS: Asbestos induces a significant (p &lt; 0.0001) increase in the NLRP3 subunit, release of proinflammatory cytokines, NLRP3-activated cytokines, NF-kappaB, and levels of nitrates/nitrites.	Asbestos	9-17	NLR family, pyrin domain containing 3	Mus musculus	72-77
29075366-4	2017	RESULTS: Asbestos induces a significant (p &lt; 0.0001) increase in the NLRP3 subunit, release of proinflammatory cytokines, NLRP3-activated cytokines, NF-kappaB, and levels of nitrates/nitrites.	Asbestos	9-17	NLR family, pyrin domain containing 3	Mus musculus	125-130
29075366-6	2017	CONCLUSIONS: LGM2605 reduced asbestos-induced NLRP3 expression, proinflammatory cytokine release, NF-kappaB activation, and nitrosative stress in MFs supporting its possible use in preventing the asbestos-induced inflammatory cascade leading to malignancy.	Asbestos	29-37	NLR family, pyrin domain containing 3	Mus musculus	46-51
28078039-10	2016	The expressions of caspase-1, NLRP3, IL-1beta, and IL-18 in LPS+ATP group were significantly higher than the control group by Western blot and ELISA.	Adenosine Triphosphate	64-67	NLR family, pyrin domain containing 3	Mus musculus	30-35
27924062-0	2016	Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis.	Chenodeoxycholic Acid	0-21	NLR family, pyrin domain containing 3	Mus musculus	32-37
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	Chenodeoxycholic Acid	49-70	NLR family, pyrin domain containing 3	Mus musculus	187-192
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	Chenodeoxycholic Acid	72-76	NLR family, pyrin domain containing 3	Mus musculus	187-192
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	Bile Acids and Salts	109-118	NLR family, pyrin domain containing 3	Mus musculus	187-192
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	ros	297-300	NLR family, pyrin domain containing 3	Mus musculus	187-192
27924062-8	2016	In conclusion, excessive CDCA may represent an endogenous danger signal to activate NLRP3 inflammasome and initiate liver inflammation during cholestasis.	Chenodeoxycholic Acid	25-29	NLR family, pyrin domain containing 3	Mus musculus	84-89
28078023-5	2016	Further, picroside II treatment alleviated the inflammatory response in sepsis and enhanced immune function by inhibiting the activation of NLRP3 inflammasome and NF-kappaB pathways.	picroside II	9-21	NLR family, pyrin domain containing 3	Mus musculus	140-145
27783111-4	2016	We used confocal microscopy to study the formation and activation of NOD-like receptor family pyrin domain containing-3 (Nlrp3) inflammasomes and expression of tight junction proteins in coronary arteries of streptozotocin-treated diabetic wild type and Nlrp3 gene-deleted mice.	Streptozocin	208-222	NLR family, pyrin domain containing 3	Mus musculus	69-119
27934918-0	2016	Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout.	caffeic acid phenethyl ester	39-67	NLR family, pyrin domain containing 3	Mus musculus	17-22
27934918-1	2016	Gouty arthritis is caused by the deposition of uric acid crystals, which induce the activation of NOD-like receptor family, pyrin domain containing 3(NLRP3) inflammasome.	Uric Acid	47-56	NLR family, pyrin domain containing 3	Mus musculus	150-155
27934918-4	2016	In primary mouse macrophages, caffeic acid phenethyl ester(CAPE) blocked caspase-1 activation and IL-1beta production induced by MSU crystals, showing that CAPE suppresses NLRP3 inflammasome activation.	caffeic acid phenethyl ester	30-58	NLR family, pyrin domain containing 3	Mus musculus	172-177
27803035-6	2016	Mice lacking the IL-1R or the inflammasome components NLRP3 and caspase-1 were protected from aldosterone-induced vascular damage.	Aldosterone	94-105	NLR family, pyrin domain containing 3	Mus musculus	54-59
27803035-7	2016	In vitro, aldosterone stimulated NLRP3-dependent interleukin-1beta secretion by bone marrow-derived macrophages by activating nuclear factor-kappaB signaling and reactive oxygen species generation.	Aldosterone	10-21	NLR family, pyrin domain containing 3	Mus musculus	33-38
27803035-7	2016	In vitro, aldosterone stimulated NLRP3-dependent interleukin-1beta secretion by bone marrow-derived macrophages by activating nuclear factor-kappaB signaling and reactive oxygen species generation.	Reactive Oxygen Species	162-185	NLR family, pyrin domain containing 3	Mus musculus	33-38
27803035-8	2016	Moreover, chimeric mice reconstituted with NLRP3-deficient hematopoietic cells showed that NLRP3 in immune cells mediates aldosterone-induced vascular damage.	Aldosterone	122-133	NLR family, pyrin domain containing 3	Mus musculus	43-48
27803035-8	2016	Moreover, chimeric mice reconstituted with NLRP3-deficient hematopoietic cells showed that NLRP3 in immune cells mediates aldosterone-induced vascular damage.	Aldosterone	122-133	NLR family, pyrin domain containing 3	Mus musculus	91-96
27803035-11	2016	CONCLUSIONS: Together, these data demonstrate that NLRP3 inflammasome, through activation of IL-1R, is critically involved in the deleterious vascular effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in conditions with high aldosterone levels.	Aldosterone	162-173	NLR family, pyrin domain containing 3	Mus musculus	51-56
27803035-11	2016	CONCLUSIONS: Together, these data demonstrate that NLRP3 inflammasome, through activation of IL-1R, is critically involved in the deleterious vascular effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in conditions with high aldosterone levels.	Aldosterone	162-173	NLR family, pyrin domain containing 3	Mus musculus	183-188
27803035-11	2016	CONCLUSIONS: Together, these data demonstrate that NLRP3 inflammasome, through activation of IL-1R, is critically involved in the deleterious vascular effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in conditions with high aldosterone levels.	Aldosterone	265-276	NLR family, pyrin domain containing 3	Mus musculus	51-56
27803035-11	2016	CONCLUSIONS: Together, these data demonstrate that NLRP3 inflammasome, through activation of IL-1R, is critically involved in the deleterious vascular effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in conditions with high aldosterone levels.	Aldosterone	265-276	NLR family, pyrin domain containing 3	Mus musculus	183-188
27643555-3	2016	In this study, we aimed to investigate the effect of resveratrol on NLRP3 inflammasome in lipopolysaccharide-induced ALI.	Resveratrol	53-64	NLR family, pyrin domain containing 3	Mus musculus	68-73
27643555-7	2016	In lung tissue, resveratrol also inhibited the LPS-induced NLRP3, ASC, caspase-1 mRNA and protein expression, and NLRP3 inflammasome activation.	Resveratrol	16-27	NLR family, pyrin domain containing 3	Mus musculus	59-64
27643555-7	2016	In lung tissue, resveratrol also inhibited the LPS-induced NLRP3, ASC, caspase-1 mRNA and protein expression, and NLRP3 inflammasome activation.	Resveratrol	16-27	NLR family, pyrin domain containing 3	Mus musculus	114-119
27643555-8	2016	Moreover, resveratrol administration not only suppressed the NF-kappaB p65 nuclear translocation, NF-kappaB activity and ROS production in the LPS-treated mice, but also inhibited the LPS-induced thioredoxin-interacting protein (TXNIP) protein expression and interaction of TXNIP-NLRP3 in lung tissue.	Resveratrol	10-21	NLR family, pyrin domain containing 3	Mus musculus	280-285
27643555-10	2016	Taken together, our study suggests that resveratrol protects against LPS-induced lung injury by NLRP3 inflammasome inhibition.	Resveratrol	40-51	NLR family, pyrin domain containing 3	Mus musculus	96-101
27966619-0	2016	NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis.	Oxazolone	51-60	NLR family, pyrin domain containing 3	Mus musculus	0-5
27966619-9	2016	Compared to wild-type mice, NLRP3-/- mice exhibited higher sensitivity to oxazolone treatment with enhancement of Th2 cytokine expression and reduction of mature IL-1beta and IL-18 production; this phenotype was rescued by exogenous IL-1beta or IL-18.	Oxazolone	74-83	NLR family, pyrin domain containing 3	Mus musculus	28-33
27803035-0	2016	NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage.	Aldosterone	28-39	NLR family, pyrin domain containing 3	Mus musculus	0-5
27803035-4	2016	RESULTS: Here, we show that NLRP3 inflammasome plays a central role in aldosterone-induced vascular dysfunction.	Aldosterone	71-82	NLR family, pyrin domain containing 3	Mus musculus	28-33
27793052-0	2016	Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-kappaB signaling and NLRP3 inflammasome activation.	andrographolide	0-15	NLR family, pyrin domain containing 3	Mus musculus	112-117
27793052-4	2016	Mechanically, Andrographolide markedly hampered the activation of nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome both in vivo and vitro thus decreased levels of TNF-alpha and IL-1beta.	andrographolide	14-29	NLR family, pyrin domain containing 3	Mus musculus	104-109
27793052-5	2016	Finally, we confirmed that ROS scavenging was responsible for Andrographolide"s inactivation of NF-kappaB and NLRP3 inflammasome signaling.	ros	27-30	NLR family, pyrin domain containing 3	Mus musculus	110-115
27793052-5	2016	Finally, we confirmed that ROS scavenging was responsible for Andrographolide"s inactivation of NF-kappaB and NLRP3 inflammasome signaling.	andrographolide	62-77	NLR family, pyrin domain containing 3	Mus musculus	110-115
27754761-3	2016	The decrease in the circulating level of the neurotransmitter dopamine in pink1-/- and park2-/- mice accelerates the release of a late sepsis mediator, HMGB1, via HIF1A-dependent anaerobic glycolysis and subsequent NLRP3-dependent inflammasome activation.	Dopamine	62-70	NLR family, pyrin domain containing 3	Mus musculus	215-220
27630169-6	2016	In wild-type hepatic macrophages, deoxycholic acid induced the association of Gal3 and NLRP3 with direct activation of the inflammasome, resulting in an increase in IL-1beta.	Deoxycholic Acid	34-50	NLR family, pyrin domain containing 3	Mus musculus	87-92
27783111-4	2016	We used confocal microscopy to study the formation and activation of NOD-like receptor family pyrin domain containing-3 (Nlrp3) inflammasomes and expression of tight junction proteins in coronary arteries of streptozotocin-treated diabetic wild type and Nlrp3 gene-deleted mice.	Streptozocin	208-222	NLR family, pyrin domain containing 3	Mus musculus	121-126
27783111-4	2016	We used confocal microscopy to study the formation and activation of NOD-like receptor family pyrin domain containing-3 (Nlrp3) inflammasomes and expression of tight junction proteins in coronary arteries of streptozotocin-treated diabetic wild type and Nlrp3 gene-deleted mice.	Streptozocin	208-222	NLR family, pyrin domain containing 3	Mus musculus	254-259
27783111-6	2016	Similarly, Nlrp3 gene silencing prevented high glucose-induced down-regulation of tight junction proteins in cultured mouse vascular endothelial cells (MVECs).	Glucose	47-54	NLR family, pyrin domain containing 3	Mus musculus	11-16
27783111-7	2016	The high glucose-induced tight junction disruption and consequent endothelial permeability were attributed to increased release of the high mobility group box protein-1 (HMGB1), which is dependent on enhanced Nlrp3 inflammasome activity.	Glucose	9-16	NLR family, pyrin domain containing 3	Mus musculus	209-214
27783111-9	2016	Collectively, the ROS-dependent activation of endothelial Nlrp3 inflammasomes by hyperglycemia may be an important initiating mechanism to cause endothelial dysfunction.	Reactive Oxygen Species	18-21	NLR family, pyrin domain containing 3	Mus musculus	58-63
27783111-12	2016	High glucose activates Nlrp3 inflammasome in endothelial cells via ROS production.	Glucose	5-12	NLR family, pyrin domain containing 3	Mus musculus	23-28
27783111-12	2016	High glucose activates Nlrp3 inflammasome in endothelial cells via ROS production.	Reactive Oxygen Species	67-70	NLR family, pyrin domain containing 3	Mus musculus	23-28
27783111-14	2016	Blockade of Nlrp3/HMGB1 axis inhibits high glucose-induced endothelial permeability.	Glucose	43-50	NLR family, pyrin domain containing 3	Mus musculus	12-17
26676570-7	2016	Furthermore, we demonstrated that miR-7 post-transcriptionally controlled Nlrp3 expression besides targeting alpha-syn.	mir-7	34-39	NLR family, pyrin domain containing 3	Mus musculus	74-79
27919184-0	2016	Role of engineered metal oxide nanoparticle agglomeration in reactive oxygen species generation and cathepsin B release in NLRP3 inflammasome activation and pulmonary toxicity.	metal oxide	19-30	NLR family, pyrin domain containing 3	Mus musculus	123-128
26676570-8	2016	Most notably, stereotactic injection of miR-7 mimics into lateral ventricles significantly inhibited NLRP3 inflammasome activation and improved adult neurogenesis in mouse SVZ.	mir-7	40-45	NLR family, pyrin domain containing 3	Mus musculus	101-106
27733681-11	2016	Collectively, these findings reveal novel anti-inflammatory activities for vitamin B6 and suggest its potential for preventing inflammatory diseases driven by the NLRP3 inflammasome.	Vitamin B 6	75-85	NLR family, pyrin domain containing 3	Mus musculus	163-168
27965665-0	2016	Deoxycholic Acid Triggers NLRP3 Inflammasome Activation and Aggravates DSS-Induced Colitis in Mice.	Deoxycholic Acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	26-31
27965665-3	2016	In this study, we sought to investigate the role and mechanism of DCA in the induction of inflammation via promoting NLRP3 inflammasome activation.	Deoxycholic Acid	66-69	NLR family, pyrin domain containing 3	Mus musculus	117-122
27965665-4	2016	Here, we, for the first time, showed that DCA dose-dependently induced NLRP3 inflammasome activation and highly pro-inflammatory cytokine-IL-1beta production in macrophages.	Deoxycholic Acid	42-45	NLR family, pyrin domain containing 3	Mus musculus	71-76
27965665-5	2016	Mechanistically, DCA-triggered NLRP3 inflammasome activation by promoting cathepsin B release at least partially through sphingosine-1-phosphate receptor 2.	Deoxycholic Acid	17-20	NLR family, pyrin domain containing 3	Mus musculus	31-36
27965665-6	2016	Colorectal instillation of DCA significantly increased mature IL-1beta level in colonic tissue and exacerbated DSS-induced colitis, while in vivo blockage of NLRP3 inflammasome or macrophage depletion dramatically reduced the mature IL-1beta production and ameliorated the aggravated inflammatory injury imposed by DCA.	Deoxycholic Acid	27-30	NLR family, pyrin domain containing 3	Mus musculus	158-163
27965665-6	2016	Colorectal instillation of DCA significantly increased mature IL-1beta level in colonic tissue and exacerbated DSS-induced colitis, while in vivo blockage of NLRP3 inflammasome or macrophage depletion dramatically reduced the mature IL-1beta production and ameliorated the aggravated inflammatory injury imposed by DCA.	Deoxycholic Acid	315-318	NLR family, pyrin domain containing 3	Mus musculus	158-163
27965665-7	2016	Thus, our findings show that high-level fecal DCA may serve as an endogenous danger signal to activate NLRP3 inflammasome and contribute to HFD-related colonic inflammation.	Deoxycholic Acid	46-49	NLR family, pyrin domain containing 3	Mus musculus	103-108
27733681-0	2016	Vitamin B6 Prevents IL-1beta Protein Production by Inhibiting NLRP3 Inflammasome Activation.	Vitamin B 6	0-10	NLR family, pyrin domain containing 3	Mus musculus	62-67
27689324-6	2016	By fluorescence microscopy and flow cytometry, we observed that such palmitate-induced Nlrp3 inflammasome activated was accompanied by a reduction in inter-endothelial tight junction proteins ZO-1/ZO-2.	Palmitates	69-78	NLR family, pyrin domain containing 3	Mus musculus	87-92
27689324-0	2016	Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.	Fatty Acids, Nonesterified	43-58	NLR family, pyrin domain containing 3	Mus musculus	98-103
27689324-9	2016	Lastly, blockade of cathepsin B with Ca-074Me significantly abolished palmitate-induced activation of Nlrp3 inflammasomes, down-regulation of ZO-1/ZO-2, and enhanced permeability in MVECs or their monolayers.	CA 074 methyl ester	37-45	NLR family, pyrin domain containing 3	Mus musculus	102-107
27689324-5	2016	In microvascular endothelial cells (MVECs), palmitate markedly induces Nlrp3 inflammasome complex formation leading to caspase-1 activation and IL1beta production.	Palmitates	44-53	NLR family, pyrin domain containing 3	Mus musculus	71-76
27689324-9	2016	Lastly, blockade of cathepsin B with Ca-074Me significantly abolished palmitate-induced activation of Nlrp3 inflammasomes, down-regulation of ZO-1/ZO-2, and enhanced permeability in MVECs or their monolayers.	Palmitates	70-79	NLR family, pyrin domain containing 3	Mus musculus	102-107
27666012-0	2016	Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells.	Dinoprostone	81-98	NLR family, pyrin domain containing 3	Mus musculus	127-132
27666012-2	2016	Bone marrow mesenchymal stem cells (BMSCs) attenuate sepsis through prostaglandin E 2 (PGE2) by increasing the interleukin-10 (IL-10) production of macrophages; moreover, NLRP3 inflammasome assembly is effectively regulated by IL-10 during infection.	Dinoprostone	68-85	NLR family, pyrin domain containing 3	Mus musculus	171-176
27769021-0	2016	The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling.	sinomenine	23-33	NLR family, pyrin domain containing 3	Mus musculus	81-86
27666012-7	2016	Furthermore, extracellular signal-regulated kinase 1 (ERK1) inhibitor reduced IL-10 production in KCs and blocked the inhibitory effect of PGE2 on the activation of the NLRP3 inflammasome.	Dinoprostone	139-143	NLR family, pyrin domain containing 3	Mus musculus	169-174
27666012-8	2016	Our data reveal a novel mechanism of BMSC-mediated suppression of the activation of KCs through the secretion of PGE2 by BMSCs, which promotes KCs to secrete IL-10, leading to the inhibition of the NLRP3 inflammasome in KCs.	Dinoprostone	113-117	NLR family, pyrin domain containing 3	Mus musculus	198-203
27276511-0	2016	Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	103-108
27306439-0	2016	Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1beta/IL-1R1/MyD88/NF-kappaB pathway.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	0-14	NLR family, pyrin domain containing 3	Mus musculus	95-100
27306439-3	2016	In this study, we explored whether a potential anti-fibrotic agent fluorofenidone (FD) exerts its anti-inflammatory and anti-fibrotic effects through suppressing activation of NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome and the IL-1beta/IL-1R1/MyD88/NF-kappaB pathway in vivo and in vitro.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	67-81	NLR family, pyrin domain containing 3	Mus musculus	176-223
27306439-3	2016	In this study, we explored whether a potential anti-fibrotic agent fluorofenidone (FD) exerts its anti-inflammatory and anti-fibrotic effects through suppressing activation of NACHT, LRR and PYD domains-containing protein 3 (NALP3) inflammasome and the IL-1beta/IL-1R1/MyD88/NF-kappaB pathway in vivo and in vitro.	5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone	67-81	NLR family, pyrin domain containing 3	Mus musculus	225-230
27779191-5	2016	Furthermore, stereotaxic injection of 25-HC into the corpus callosum of mouse brains induces microglial recruitment, interleukin-1beta production, and oligodendrocyte cell death in an NLRP3 inflammasome-dependent manner.	25-hydroxycholesterol	38-43	NLR family, pyrin domain containing 3	Mus musculus	184-189
27450485-7	2016	Furthermore, casticin suppressed LPS-induced NF-kappaB activation, and NLRP3, ASC, and caspase-1 expression.	casticin	13-21	NLR family, pyrin domain containing 3	Mus musculus	71-76
27450485-9	2016	Casticin protected against LPS-induced ALI by inhibiting inflammatory cytokines production through the inhibition of NF-kappaB and NLRP3 signaling pathways.	casticin	0-8	NLR family, pyrin domain containing 3	Mus musculus	131-136
27306439-15	2016	This study demonstrated that FD, attenuates BLM-induced pulmonary inflammation and fibrosis in mice via inhibiting the activation of NALP3 inflammasome and the IL-1beta/IL-1R1/MyD88/ NF-kappaB pathway.	Bleomycin	44-47	NLR family, pyrin domain containing 3	Mus musculus	133-138
27276511-0	2016	Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice.	Resveratrol	14-25	NLR family, pyrin domain containing 3	Mus musculus	103-108
27276511-1	2016	OBJECTIVE: This study was designed to investigate the hypothesis that metformin and resveratrol exhibited the same effect on inhibition of NLRP3 inflammasome activation with regulation of AMPK in adipose tissue exposed to high glucose.	Metformin	70-79	NLR family, pyrin domain containing 3	Mus musculus	139-144
27276511-1	2016	OBJECTIVE: This study was designed to investigate the hypothesis that metformin and resveratrol exhibited the same effect on inhibition of NLRP3 inflammasome activation with regulation of AMPK in adipose tissue exposed to high glucose.	Resveratrol	84-95	NLR family, pyrin domain containing 3	Mus musculus	139-144
27276511-5	2016	As a result from suppressing TXNIP/NLRP3 inflammasome activation, metformin and resveratrol inhibited inflammation and reduced cell apoptosis in adipose tissue or adipocytes exposed to high glucose.	Resveratrol	80-91	NLR family, pyrin domain containing 3	Mus musculus	35-40
27276511-6	2016	CONCLUSION: Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult.	Metformin	12-21	NLR family, pyrin domain containing 3	Mus musculus	114-119
27276511-6	2016	CONCLUSION: Metformin and resveratrol protected mitochondrial integrity by inhibiting Drp1 activity and prevented NLRP3 inflammasome activation by suppressing ER stress, and thereby protected adipose function from high glucose insult.	Resveratrol	26-37	NLR family, pyrin domain containing 3	Mus musculus	114-119
27440421-1	2016	The aim of this study was to evaluate the effects of chronic treatment with empagliflozin, a potent and selective sodium glucose cotransporter-2 inhibitor, in a murine model of diet-induced obesity and insulin resistance, focusing on drug effects on body weight reduction and nucleotide-binding domain, leucine-rich repeat containing protein (NLRP)-3 inflammasome activation, which have never been investigated to date.	empagliflozin	76-89	NLR family, pyrin domain containing 3	Mus musculus	303-350
27721446-0	2016	Stabilization of endogenous Nrf2 by minocycline protects against Nlrp3-inflammasome induced diabetic nephropathy.	Minocycline	36-47	NLR family, pyrin domain containing 3	Mus musculus	65-70
27721446-9	2016	Accordingly, minocycline mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2-/- mice.	Minocycline	13-24	NLR family, pyrin domain containing 3	Mus musculus	34-39
27439970-0	2016	NLRP3 inflammasome as a target of berberine in experimental murine liver injury: interference with P2X7 signalling.	Berberine	34-43	NLR family, pyrin domain containing 3	Mus musculus	0-5
27594529-0	2016	Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure.	Silicon Dioxide	108-114	NLR family, pyrin domain containing 3	Mus musculus	45-50
27522260-5	2016	Further investigation indicated that astilbin prevented the renal damage against the expression of Thioredoxin-interacting protein (TXNIP) and its related inflammation signal pathway, including NLR pyrin domain-containing 3/Nuclear factor kappaB (NLRP3/NF-kappaB), which is associated with the up-regulation of interleukin-1beta (IL-1beta) and interleukin-18 (IL-18), and also presented a renal protective role by suppression oxidative stress.	astilbin	37-45	NLR family, pyrin domain containing 3	Mus musculus	247-252
27315109-9	2016	Finally, alum was able to activate NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in murine basophils in the same way as alum in professional antigen-presenting cells, but NLRP3 was not required for Th2-promoting activities on basophils by alum in vitro.	th2	221-224	NLR family, pyrin domain containing 3	Mus musculus	84-89
27440421-7	2016	Moreover, diet-induced activation of NLRP-3 in kidney and liver (not observed in the heart) was dose-dependently attenuated by empagliflozin.	empagliflozin	127-140	NLR family, pyrin domain containing 3	Mus musculus	37-43
27440421-9	2016	Most notably, empagliflozin treatment was associated with NLRP-3 inflammasome signaling modulation, suggesting that this inhibition may contribute to the drug therapeutic effects.	empagliflozin	14-27	NLR family, pyrin domain containing 3	Mus musculus	58-64
27566281-7	2016	These data indicate that UCP2 negatively regulates the activation of NLRP3 inflammasome and inhibited the ROS-TXNIP-NLRP3 pathway in astrocytes.	Reactive Oxygen Species	106-109	NLR family, pyrin domain containing 3	Mus musculus	116-121
27234527-9	2016	In addition, EGCG treatment suppressed NLRP3 inflammasome activation in MSU-challenged THP-1 monocytes.	epigallocatechin gallate	13-17	NLR family, pyrin domain containing 3	Mus musculus	39-44
26956548-0	2016	Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation.	Silver	27-33	NLR family, pyrin domain containing 3	Mus musculus	81-86
27234527-8	2016	Furthermore, EGCG decreased MSU-triggered neutrophil cytosolic factor 1 and NLRP3 protein expression, limiting pro-inflammatory mediator secretion such as IL-1beta, IL-6, monocyte chemoattractant protein-1, and serum amyloid A.	epigallocatechin gallate	13-17	NLR family, pyrin domain containing 3	Mus musculus	76-81
27585971-0	2016	Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome.	Colchicine	0-10	NLR family, pyrin domain containing 3	Mus musculus	90-95
27207922-0	2016	Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression.	Fluoxetine	0-10	NLR family, pyrin domain containing 3	Mus musculus	20-25
27207922-4	2016	METHODS: We used a chronic mild stress model and cultured primary macrophage/microglia to investigate the effects of fluoxetine on NLRP3 inflammasome and its underlying mechanisms.	Fluoxetine	117-127	NLR family, pyrin domain containing 3	Mus musculus	131-136
27207922-5	2016	RESULTS: We demonstrated that fluoxetine significantly suppressed NLRP3 inflammasome activation, subsequent caspase-1 cleavage, and interleukin-1beta secretion in both peripheral macrophages and central microglia.	Fluoxetine	30-40	NLR family, pyrin domain containing 3	Mus musculus	66-71
27207922-6	2016	We further found that fluoxetine reduced reactive oxygen species production, attenuated the phosphorylation of double-stranded RNA-dependent protein kinase, and inhibited the association of protein kinase with NLRP3.	Fluoxetine	22-32	NLR family, pyrin domain containing 3	Mus musculus	210-215
27207922-7	2016	These data indicate that fluoxetine inhibits the activation of NLRP3 inflammasome via downregulating reactive oxygen species-protein kinase-NLRP3 signaling pathway.	Fluoxetine	25-35	NLR family, pyrin domain containing 3	Mus musculus	63-68
27207922-7	2016	These data indicate that fluoxetine inhibits the activation of NLRP3 inflammasome via downregulating reactive oxygen species-protein kinase-NLRP3 signaling pathway.	Fluoxetine	25-35	NLR family, pyrin domain containing 3	Mus musculus	140-145
27207922-8	2016	Correspondingly, in vivo data showed that fluoxetine also suppressed NLRP3 inflammasome activation in hippocampus and macrophages of chronic mild stress mice and alleviated chronic mild stress-induced depression-like behavior.	Fluoxetine	42-52	NLR family, pyrin domain containing 3	Mus musculus	69-74
27207922-9	2016	CONCLUSIONS: Our findings reveal that fluoxetine confers an antidepressant effect partly through inhibition of peripheral and central NLRP3 inflammasome activation and suggest the potential clinical use of fluoxetine in NLRP3 inflammasome-driven inflammatory diseases such as depression.	Fluoxetine	38-48	NLR family, pyrin domain containing 3	Mus musculus	134-139
27207922-9	2016	CONCLUSIONS: Our findings reveal that fluoxetine confers an antidepressant effect partly through inhibition of peripheral and central NLRP3 inflammasome activation and suggest the potential clinical use of fluoxetine in NLRP3 inflammasome-driven inflammatory diseases such as depression.	Fluoxetine	38-48	NLR family, pyrin domain containing 3	Mus musculus	220-225
27207922-9	2016	CONCLUSIONS: Our findings reveal that fluoxetine confers an antidepressant effect partly through inhibition of peripheral and central NLRP3 inflammasome activation and suggest the potential clinical use of fluoxetine in NLRP3 inflammasome-driven inflammatory diseases such as depression.	Fluoxetine	206-216	NLR family, pyrin domain containing 3	Mus musculus	134-139
27207922-9	2016	CONCLUSIONS: Our findings reveal that fluoxetine confers an antidepressant effect partly through inhibition of peripheral and central NLRP3 inflammasome activation and suggest the potential clinical use of fluoxetine in NLRP3 inflammasome-driven inflammatory diseases such as depression.	Fluoxetine	206-216	NLR family, pyrin domain containing 3	Mus musculus	220-225
27521339-0	2016	Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.	cp-456	62-68	NLR family, pyrin domain containing 3	Mus musculus	33-38
27521339-3	2016	In this study, we further define the pharmacology of the previously reported NLRP3 inflammasome-selective, IL-1beta processing inhibitor CP-456,773 (also known as MCC950), and we demonstrate its efficacy in two in vivo models of inflammation.	cp-456	137-143	NLR family, pyrin domain containing 3	Mus musculus	77-82
27521339-4	2016	Specifically, we show that in human and mouse innate immune cells CP-456,773 is an inhibitor of the cellular release of IL-1beta, IL-1alpha, and IL-18, that CP-456,773 prevents inflammasome activation induced by disease-relevant soluble and crystalline NLRP3 stimuli, and that CP-456,773 inhibits R848- and imiquimod-induced IL-1beta release.	cp-456	157-163	NLR family, pyrin domain containing 3	Mus musculus	253-258
27528423-5	2016	The inhibition of NLRP3 by means of glybenclamide significantly reduced IL-1beta release.	Glyburide	36-49	NLR family, pyrin domain containing 3	Mus musculus	18-23
27528423-10	2016	In contrast, the depletion of TAMs by means of clodronate liposomes reduced lung tumorigenesis, associated to lower in vivo release of IL-1alpha and IL-1beta.In conclusion, our data imply lung tumor lesions are populated by macrophages which pro-tumor activity is regulated by the activation of the NLRP3 inflammasome that leads to the release of IL-1alpha and IL-1beta in a caspase-11/caspase-1-dependent manner.	tams	30-34	NLR family, pyrin domain containing 3	Mus musculus	299-304
27431618-4	2016	This study investigated the role of genistein supplementation in inflammation and oxidative stress, which are related to NLRP3 inflammasome, NFkappaB and Nrf2 activation, during cutaneous wound healing in alloxan-induced diabetic mice.	Genistein	36-45	NLR family, pyrin domain containing 3	Mus musculus	121-126
27431618-8	2016	Moreover, genistein supplementation restored NLRP3 inflammasome (NLRP3, ASC and caspase-1) at the basal level and ameliorated both inflammation (TNFalpha, iNOS, COX2 and NFkappaB) and antioxidant defense system (Nrf2, HO-1, GPx, and catalase) during early stage of wound healing in diabetic mice.	Genistein	10-19	NLR family, pyrin domain containing 3	Mus musculus	45-50
27431618-8	2016	Moreover, genistein supplementation restored NLRP3 inflammasome (NLRP3, ASC and caspase-1) at the basal level and ameliorated both inflammation (TNFalpha, iNOS, COX2 and NFkappaB) and antioxidant defense system (Nrf2, HO-1, GPx, and catalase) during early stage of wound healing in diabetic mice.	Genistein	10-19	NLR family, pyrin domain containing 3	Mus musculus	65-70
27521339-4	2016	Specifically, we show that in human and mouse innate immune cells CP-456,773 is an inhibitor of the cellular release of IL-1beta, IL-1alpha, and IL-18, that CP-456,773 prevents inflammasome activation induced by disease-relevant soluble and crystalline NLRP3 stimuli, and that CP-456,773 inhibits R848- and imiquimod-induced IL-1beta release.	cp-456	157-163	NLR family, pyrin domain containing 3	Mus musculus	253-258
27611972-7	2016	In vivo, HU308 treatment attenuated DSS-induced colitis mice associated with reduced colon inflammation and inhibited NLRP3 inflammasome activation in wild-type mice.	HU 308	9-14	NLR family, pyrin domain containing 3	Mus musculus	118-123
27585971-7	2016	Indomethacin-induced small intestinal damage was reduced by 77%, as determined by the lesion index in NLRP3(-/-) mice, and colchicine treatment failed to inhibit small intestinal damage in NLRP3(-/-) mice.	Indomethacin	0-12	NLR family, pyrin domain containing 3	Mus musculus	102-107
27585971-8	2016	These results demonstrate that colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome.	Colchicine	31-41	NLR family, pyrin domain containing 3	Mus musculus	121-126
28598075-0	2016	[The Protective Effect of Tanshinone IIA on Oxygen-glucose Deprivation and Reperfusion Injury of MicrogliaThrough the NLRP3 Inflammatory Signaling Pathway].	tanshinone	26-40	NLR family, pyrin domain containing 3	Mus musculus	118-123
27262364-2	2016	Here, we studied whether a specific inhibitor of the Nlrp3 inflammasome, CP-456,773, can prevent kidney fibrosis in a murine model of crystal nephropathy induced by diets rich in oxalate or adenine.	cp-456	73-79	NLR family, pyrin domain containing 3	Mus musculus	53-58
27262364-8	2016	Thus, early NLRP3 inhibition by CP-456,773 may be an effective treatment for crystal nephropathy.	cp-456	32-38	NLR family, pyrin domain containing 3	Mus musculus	12-17
27455510-0	2016	NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.	dependent	5-14	NLR family, pyrin domain containing 3	Mus musculus	45-50
27455510-0	2016	NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages.	Fatty Acids	15-25	NLR family, pyrin domain containing 3	Mus musculus	45-50
27455510-7	2016	We also found that inhibition of FAO by etomoxir treatment suppressed NLRP3 inflammasome activation.	etomoxir	40-48	NLR family, pyrin domain containing 3	Mus musculus	70-75
28598075-4	2016	In TSA 0 (also called OGD group), 0.5, 1.0, 2.0 ug/mL groups, expression levels of NLRP3 and caspase-1 were detected by Western blot, while IL-1beta and IL-18 in culture medium of those groups were detected by ELISA assay.	tanshinone	3-6	NLR family, pyrin domain containing 3	Mus musculus	83-88
28598075-7	2016	The expression levels of NLRP3, caspase-1, IL-1beta and IL-18 decreased with the increase of TSA concentration.	tanshinone	93-96	NLR family, pyrin domain containing 3	Mus musculus	25-30
28598075-8	2016	CONCLUSIONS: TSA can inhibit the expression of protein and cytokines of NLRP3 inflammatory signaling pathway in OGD/R BV-2 cells, which may be one of the molecular mechanisms of the protective effect of TSA on OGD/R cells.	tanshinone	13-16	NLR family, pyrin domain containing 3	Mus musculus	72-77
28598075-8	2016	CONCLUSIONS: TSA can inhibit the expression of protein and cytokines of NLRP3 inflammatory signaling pathway in OGD/R BV-2 cells, which may be one of the molecular mechanisms of the protective effect of TSA on OGD/R cells.	tanshinone	203-206	NLR family, pyrin domain containing 3	Mus musculus	72-77
27509058-6	2016	MitoTEMPO, a mitochondrial targeted antioxidant, attenuated Ang II induced mitochondrial reactive oxygen species (mROS) production and NLRP3 inflammation activation.	MitoTEMPO	0-9	NLR family, pyrin domain containing 3	Mus musculus	135-140
27483033-2	2016	In addition, the chain-like structure and reactive surface silanols also allow fumed silica to activate the NLRP3 inflammasome, leading to IL-1beta production.	silanol	59-67	NLR family, pyrin domain containing 3	Mus musculus	108-113
27483033-2	2016	In addition, the chain-like structure and reactive surface silanols also allow fumed silica to activate the NLRP3 inflammasome, leading to IL-1beta production.	Silicon Dioxide	85-91	NLR family, pyrin domain containing 3	Mus musculus	108-113
27483033-5	2016	In contrast, the NLRP3 inflammasome pathway was continuously activated by repetitive-dose administration of 3 x 7 mg/kg fumed silica, 1 week apart.	Silicon Dioxide	126-132	NLR family, pyrin domain containing 3	Mus musculus	17-22
27509058-10	2016	As expected, Ang II-induced mitochondrial dysfunction and NLRP3 inflammasome activation was markedly inhibited by mitoTEMPO.	MitoTEMPO	114-123	NLR family, pyrin domain containing 3	Mus musculus	58-63
27421477-0	2016	Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	47-52
27535180-0	2016	15-Lipoxygenase metabolites of alpha-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome.	alpha-Linolenic Acid	31-51	NLR family, pyrin domain containing 3	Mus musculus	137-142
27535180-0	2016	15-Lipoxygenase metabolites of alpha-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome.	13-(s)-hpotre	54-67	NLR family, pyrin domain containing 3	Mus musculus	137-142
27535180-0	2016	15-Lipoxygenase metabolites of alpha-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome.	13-(s)-hotre	72-84	NLR family, pyrin domain containing 3	Mus musculus	137-142
27535180-7	2016	These studies reveal the anti-inflammatory effects of 13-(S)-hydroperoxyoctadecatrienoic acid [13-(S)-HPOTrE] and 13-(S)-hydroxyoctadecatrienoic acid [13-(S)-HOTrE] by inactivating NLRP3 inflammasome complex through the PPAR-gamma pathway.	13-(s)-hydroperoxyoctadecatrienoic acid	54-93	NLR family, pyrin domain containing 3	Mus musculus	181-186
27535180-7	2016	These studies reveal the anti-inflammatory effects of 13-(S)-hydroperoxyoctadecatrienoic acid [13-(S)-HPOTrE] and 13-(S)-hydroxyoctadecatrienoic acid [13-(S)-HOTrE] by inactivating NLRP3 inflammasome complex through the PPAR-gamma pathway.	13-(s)-hydroxyoctadecatrienoic acid	114-149	NLR family, pyrin domain containing 3	Mus musculus	181-186
27385778-3	2016	We assayed propidium(2+) (Pro(2+)) influx kinetics during NLRP3 or Pyrin inflammasome activation in murine bone marrow-derived macrophages (BMDMs) as an indicator of this PM permeabilization.	propidium(2+)	11-24	NLR family, pyrin domain containing 3	Mus musculus	58-63
26883974-9	2016	Decreased ET-1 levels were associated with greater activation of NLRP3 and IL-1beta in normal glucose.	Glucose	94-101	NLR family, pyrin domain containing 3	Mus musculus	65-70
26883974-10	2016	High glucose increased NLRP3 markers and activation compared to normal and low glucose.	Glucose	5-12	NLR family, pyrin domain containing 3	Mus musculus	23-28
27421477-6	2016	Furthermore, sodium orthovanadate-induced phosphorylation of ASC Y144, necessary and sufficient for Nlrp3 inflammasome activation, and secretion of phosphorylated ASC were inhibited by ethanol.	Sodium orthovanadate	13-33	NLR family, pyrin domain containing 3	Mus musculus	100-105
27421477-0	2016	Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation.	Alcohols	30-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
27421477-6	2016	Furthermore, sodium orthovanadate-induced phosphorylation of ASC Y144, necessary and sufficient for Nlrp3 inflammasome activation, and secretion of phosphorylated ASC were inhibited by ethanol.	Ethanol	185-192	NLR family, pyrin domain containing 3	Mus musculus	100-105
27421477-2	2016	The NLRP3 inflammasome, a multiprotein intracellular pattern recognition receptor complex that facilitates the cleavage and secretion of the proinflammatory cytokines IL-1beta and IL-18, can be inhibited by ethanol, and we sought to better understand the mechanism through which this occurs and whether chemically similar molecules exert comparable effects.	Ethanol	207-214	NLR family, pyrin domain containing 3	Mus musculus	4-9
27421477-7	2016	Finally, multiple alcohol-containing organic compounds exerted inhibitory effects on the Nlrp3 inflammasome, whereas 2-methylbutane (isopentane), the analogous alkane of the potent inhibitor isoamyl alcohol (isopentanol), did not.	Alcohols	18-25	NLR family, pyrin domain containing 3	Mus musculus	89-94
27421477-3	2016	We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow-derived dendritic cells, mouse neutrophils, and human PBMCs.	Ethanol	13-20	NLR family, pyrin domain containing 3	Mus musculus	64-69
27421477-3	2016	We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow-derived dendritic cells, mouse neutrophils, and human PBMCs.	Potassium	276-285	NLR family, pyrin domain containing 3	Mus musculus	64-69
27421477-7	2016	Finally, multiple alcohol-containing organic compounds exerted inhibitory effects on the Nlrp3 inflammasome, whereas 2-methylbutane (isopentane), the analogous alkane of the potent inhibitor isoamyl alcohol (isopentanol), did not.	isopentyl alcohol	191-206	NLR family, pyrin domain containing 3	Mus musculus	89-94
27421477-7	2016	Finally, multiple alcohol-containing organic compounds exerted inhibitory effects on the Nlrp3 inflammasome, whereas 2-methylbutane (isopentane), the analogous alkane of the potent inhibitor isoamyl alcohol (isopentanol), did not.	isopentyl alcohol	208-219	NLR family, pyrin domain containing 3	Mus musculus	89-94
27421477-8	2016	Our results demonstrate that ethanol antagonizes the NLRP3 inflammasome at an apical event in its activation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-chain alcohols.	Ethanol	29-36	NLR family, pyrin domain containing 3	Mus musculus	53-58
27421477-8	2016	Our results demonstrate that ethanol antagonizes the NLRP3 inflammasome at an apical event in its activation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-chain alcohols.	Alcohols	205-213	NLR family, pyrin domain containing 3	Mus musculus	53-58
27547413-0	2016	Dipeptidyl peptidase-4 inhibition by Saxagliptin prevents inflammation and renal injury by targeting the Nlrp3/ASC inflammasome.	saxagliptin	37-48	NLR family, pyrin domain containing 3	Mus musculus	105-110
27509875-0	2016	Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer"s disease in rodent models.	Fenamates	0-8	NLR family, pyrin domain containing 3	Mus musculus	28-33
27509875-3	2016	Here we show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes.	Fenamates	76-84	NLR family, pyrin domain containing 3	Mus musculus	137-142
27509875-4	2016	Flufenamic acid and mefenamic acid are efficacious in NLRP3-dependent rodent models of inflammation in air pouch and peritoneum.	Flufenamic Acid	0-15	NLR family, pyrin domain containing 3	Mus musculus	54-59
27509875-4	2016	Flufenamic acid and mefenamic acid are efficacious in NLRP3-dependent rodent models of inflammation in air pouch and peritoneum.	Mefenamic Acid	20-34	NLR family, pyrin domain containing 3	Mus musculus	54-59
27509875-6	2016	These data suggest that fenamate NSAIDs could be repurposed as NLRP3 inflammasome inhibitors and Alzheimer"s disease therapeutics.	Fenamates	24-32	NLR family, pyrin domain containing 3	Mus musculus	63-68
27547413-13	2016	Kidney and adipose protein levels of apoptosis-associated speck-like protein 1, NLRP3, TNFalpha and Caspase-1 were higher in the BTBR and Akita mice than in the WT mice.	btbr	129-133	NLR family, pyrin domain containing 3	Mus musculus	80-85
27423466-0	2016	Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	38-43
26933834-10	2016	Bleomycin-exposed aged NLRP3(-/-) mice had reduced fibrosis compared with their wild-type age-matched counterparts.	Bleomycin	0-9	NLR family, pyrin domain containing 3	Mus musculus	23-28
26933834-11	2016	Bone marrow-derived and alveolar macrophages from aged mice displayed higher levels of NLRP3 inflammasome activation and caspase-1-dependent IL-1beta and IL-18 production, which was associated with altered mitochondrial function and increased production of reactive oxygen species.	Reactive Oxygen Species	257-280	NLR family, pyrin domain containing 3	Mus musculus	87-92
26891693-8	2016	The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux.	Potassium	122-131	NLR family, pyrin domain containing 3	Mus musculus	17-22
27423466-7	2016	Lastly, SFN inhibited generation of mitochondrial reactive oxygen species, which trigger NLRP3 inflammasome activation.	Reactive Oxygen Species	50-73	NLR family, pyrin domain containing 3	Mus musculus	89-94
27423466-8	2016	Thus, SFN is suggested as an anti-inflammasome molecule for NLRP3 and NLRC4 inflammasome activation.	sulforaphane	6-9	NLR family, pyrin domain containing 3	Mus musculus	60-65
27465336-9	2016	Furthermore, prophylactic administration of telmisartan markedly inhibited BBB impairment, NLRP3, apoptotic speck-containing protein (ASC) and Caspase-1 activation, as well as IL-1beta and IL-18 maturation, subsequently improved the neurological outcomes.	Telmisartan	44-55	NLR family, pyrin domain containing 3	Mus musculus	91-96
27465336-10	2016	In conclusion, telmisartan can reduce traumatic cerebral edema by inhibiting the NLRP3 inflammasome-regulated IL-1beta and IL-18 accumulation.	Telmisartan	15-26	NLR family, pyrin domain containing 3	Mus musculus	81-86
27184504-9	2016	Taken together, our results demonstrated the ability of DMF to inhibit NLRP3 inflammasome activation and its potential use in the treatment of NLRP3-associated diseases.	Dimethyl Fumarate	56-59	NLR family, pyrin domain containing 3	Mus musculus	71-76
27467658-5	2016	While shikonin has previously been reported to suppress the priming step, we demonstrated that shikonin also inhibits the second step of inflammasome activation induced by soluble and particulate NLRP3 instigators in primed immortalized murine bone marrow-derived macrophages.	shikonin	95-103	NLR family, pyrin domain containing 3	Mus musculus	196-201
27467658-6	2016	Shikonin decreased NLRP3 inflammasome activation in response to nigericin more potently than acetylshikonin.	Nigericin	64-73	NLR family, pyrin domain containing 3	Mus musculus	19-24
27184504-0	2016	Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.	Dimethyl Fumarate	0-17	NLR family, pyrin domain containing 3	Mus musculus	124-129
27184504-0	2016	Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation.	Dextran Sulfate	30-52	NLR family, pyrin domain containing 3	Mus musculus	124-129
27157410-11	2016	In vitro, COV08-0064 selectively blocked mRNA upregulation of TNF-alpha, IL-1beta, NLRP3 and MCP-1 in macrophages and IFN-beta mRNA in dendritic cells induced by the TLR9 agonist CpG-ODN.	6-N-methylnaltrexamine	10-20	NLR family, pyrin domain containing 3	Mus musculus	83-88
27184504-6	2016	At the same time, decreased activation of caspase-1 was detected in DMF-treated mice, indicating that the NLRP3 inflammasome activation was suppressed.	Dimethyl Fumarate	68-71	NLR family, pyrin domain containing 3	Mus musculus	106-111
27184504-9	2016	Taken together, our results demonstrated the ability of DMF to inhibit NLRP3 inflammasome activation and its potential use in the treatment of NLRP3-associated diseases.	Dimethyl Fumarate	56-59	NLR family, pyrin domain containing 3	Mus musculus	143-148
27184504-7	2016	The in vitro study verified a negative regulation of DMF and its intestinal metabolite on NLRP3 inflammasome.	Dimethyl Fumarate	53-56	NLR family, pyrin domain containing 3	Mus musculus	90-95
27345021-8	2016	The NLRP3 inflammasome senses chemically diverse PAMPs and damage associated molecular patterns (DAMPs), including extracellular ATP and iron-containing heme.	Adenosine Triphosphate	129-132	NLR family, pyrin domain containing 3	Mus musculus	4-9
26731380-6	2016	Ozone-induced changes were associated with increased Nod-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 activation and p38 mitogen-activated protein kinase phosphorylation and decreased Akt phosphorylation.	Ozone	0-5	NLR family, pyrin domain containing 3	Mus musculus	98-103
26731380-9	2016	In conclusion, NaHS administration prevented and partially reversed ozone-induced features of lung inflammation and emphysema via regulation of the NLRP3-caspase-1, p38 mitogen-activated protein kinase, and Akt pathways.	sodium bisulfide	15-19	NLR family, pyrin domain containing 3	Mus musculus	148-153
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	129-134
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	136-141
27191349-7	2016	Oxalate crystals have been shown to activate the NOD-like receptor family, pyrin domain containing 3 inflammasome (also known as NALP3, NLRP3, or cryopyrin), resulting in release of IL-1beta and macrophage infiltration.	Oxalates	0-7	NLR family, pyrin domain containing 3	Mus musculus	146-155
27170638-4	2016	We used Leu-Leu-O-methyl ester (LLME), a soluble lysosomotropic agent, to quantitatively track the kinetics and extent of LMP in relation to NLRP3 inflammasome signaling responses (ASC oligomerization, caspase-1 activation, IL-1beta release) and PM cation fluxes in murine bone marrow-derived dendritic cells (BMDCs).	llme	32-36	NLR family, pyrin domain containing 3	Mus musculus	141-146
27170638-4	2016	We used Leu-Leu-O-methyl ester (LLME), a soluble lysosomotropic agent, to quantitatively track the kinetics and extent of LMP in relation to NLRP3 inflammasome signaling responses (ASC oligomerization, caspase-1 activation, IL-1beta release) and PM cation fluxes in murine bone marrow-derived dendritic cells (BMDCs).	(2~{s},3~{r},4~{s})-2-[(2~{s},3~{r})-1,3-Bis(Oxidanyl)-1-Oxidanylidene-Butan-2-Yl]-4-[(3~{s},5~{s})-5-(Dimethylcarbamoyl)pyrrolidin-3-Yl]sulfanyl-3-Methyl-3,4-Dihydro-2~{h}-Pyrrole-5-Carboxylic Acid	122-125	NLR family, pyrin domain containing 3	Mus musculus	141-146
27170638-7	2016	Supramillimolar LLME also induced dominant negative effects on inflammasome activation by the canonical NLRP3 agonist nigericin; this inhibition correlated with an increase in NLRP3 ubiquitination.	Nigericin	118-127	NLR family, pyrin domain containing 3	Mus musculus	104-109
27345021-8	2016	The NLRP3 inflammasome senses chemically diverse PAMPs and damage associated molecular patterns (DAMPs), including extracellular ATP and iron-containing heme.	Iron	137-141	NLR family, pyrin domain containing 3	Mus musculus	4-9
27345021-8	2016	The NLRP3 inflammasome senses chemically diverse PAMPs and damage associated molecular patterns (DAMPs), including extracellular ATP and iron-containing heme.	Heme	153-157	NLR family, pyrin domain containing 3	Mus musculus	4-9
27189966-0	2016	Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes.	anandamide	21-31	NLR family, pyrin domain containing 3	Mus musculus	88-93
27189966-0	2016	Protective Action of Anandamide and Its COX-2 Metabolite against l-Homocysteine-Induced NLRP3 Inflammasome Activation and Injury in Podocytes.	Homocysteine	65-79	NLR family, pyrin domain containing 3	Mus musculus	88-93
27189966-2	2016	Given the demonstrated anti-inflammatory effects of endocannabinoids, the present study was designed to test whether anandamide (AEA) or its metabolites diminish NLRP3 inflammasome activation and prevent podocyte injury and associated glomerular damage during hyperhomocysteinemia (hHcys).	anandamide	129-132	NLR family, pyrin domain containing 3	Mus musculus	162-167
27189966-1	2016	Recent studies have demonstrated that l-homocysteine (Hcys)-induced podocyte injury leading to glomerular damage or sclerosis is attributable to the activation of the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome.	Homocysteine	38-52	NLR family, pyrin domain containing 3	Mus musculus	167-248
27189966-3	2016	AEA (100 muM) inhibited Hcys-induced NLRP3 inflammasome activation in cultured podocytes, as indicated by elevated caspase-1 activity and interleukin-1beta levels, and attenuated podocyte dysfunction, as shown by reduced vascular endothelial growth factor production.	anandamide	0-3	NLR family, pyrin domain containing 3	Mus musculus	37-42
27189966-1	2016	Recent studies have demonstrated that l-homocysteine (Hcys)-induced podocyte injury leading to glomerular damage or sclerosis is attributable to the activation of the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome.	Homocysteine	38-52	NLR family, pyrin domain containing 3	Mus musculus	250-255
27189966-3	2016	AEA (100 muM) inhibited Hcys-induced NLRP3 inflammasome activation in cultured podocytes, as indicated by elevated caspase-1 activity and interleukin-1beta levels, and attenuated podocyte dysfunction, as shown by reduced vascular endothelial growth factor production.	Homocysteine	24-28	NLR family, pyrin domain containing 3	Mus musculus	37-42
27189966-1	2016	Recent studies have demonstrated that l-homocysteine (Hcys)-induced podocyte injury leading to glomerular damage or sclerosis is attributable to the activation of the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome.	Homocysteine	54-58	NLR family, pyrin domain containing 3	Mus musculus	167-248
27189966-5	2016	In mice in vivo, AEA treatment attenuated glomerular NLRP3 inflammasome activation induced by hHcys accompanying a folate-free diet, on the basis of inhibition of hHcys-induced colocalization of NLRP3 molecules and increased interleukin-1beta levels in glomeruli.	anandamide	17-20	NLR family, pyrin domain containing 3	Mus musculus	53-58
27189966-5	2016	In mice in vivo, AEA treatment attenuated glomerular NLRP3 inflammasome activation induced by hHcys accompanying a folate-free diet, on the basis of inhibition of hHcys-induced colocalization of NLRP3 molecules and increased interleukin-1beta levels in glomeruli.	anandamide	17-20	NLR family, pyrin domain containing 3	Mus musculus	195-200
27189966-1	2016	Recent studies have demonstrated that l-homocysteine (Hcys)-induced podocyte injury leading to glomerular damage or sclerosis is attributable to the activation of the nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome.	Homocysteine	54-58	NLR family, pyrin domain containing 3	Mus musculus	250-255
27189966-5	2016	In mice in vivo, AEA treatment attenuated glomerular NLRP3 inflammasome activation induced by hHcys accompanying a folate-free diet, on the basis of inhibition of hHcys-induced colocalization of NLRP3 molecules and increased interleukin-1beta levels in glomeruli.	Folic Acid	115-121	NLR family, pyrin domain containing 3	Mus musculus	53-58
27189966-7	2016	Hcys- and AEA-induced effects were absent in NLRP3-knockout mice.	Homocysteine	0-4	NLR family, pyrin domain containing 3	Mus musculus	45-50
27189966-2	2016	Given the demonstrated anti-inflammatory effects of endocannabinoids, the present study was designed to test whether anandamide (AEA) or its metabolites diminish NLRP3 inflammasome activation and prevent podocyte injury and associated glomerular damage during hyperhomocysteinemia (hHcys).	anandamide	117-127	NLR family, pyrin domain containing 3	Mus musculus	162-167
27189966-7	2016	Hcys- and AEA-induced effects were absent in NLRP3-knockout mice.	anandamide	10-13	NLR family, pyrin domain containing 3	Mus musculus	45-50
27105502-0	2016	MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-kappaB and NLRP3 inflammasome activation.	Dextran Sulfate	44-47	NLR family, pyrin domain containing 3	Mus musculus	114-119
27189966-8	2016	These beneficial effects of AEA against hHcys-induced NLRP3 inflammasome activation and glomerular injury were not observed in mice cotreated with CEL.	anandamide	28-31	NLR family, pyrin domain containing 3	Mus musculus	54-59
27189966-9	2016	We further demonstrated that prostaglandin E2-ethanolamide (PGE2-EA), a COX-2 product of AEA, at 10 muM had a similar inhibitory effect to that of 100 muM AEA on Hcys-induced NLRP3 inflammasome formation and activation in cultured podocytes.	prostaglandin E2 ethanolamide	29-58	NLR family, pyrin domain containing 3	Mus musculus	175-180
27189966-9	2016	We further demonstrated that prostaglandin E2-ethanolamide (PGE2-EA), a COX-2 product of AEA, at 10 muM had a similar inhibitory effect to that of 100 muM AEA on Hcys-induced NLRP3 inflammasome formation and activation in cultured podocytes.	prostaglandin E2 ethanolamide	60-67	NLR family, pyrin domain containing 3	Mus musculus	175-180
27189966-9	2016	We further demonstrated that prostaglandin E2-ethanolamide (PGE2-EA), a COX-2 product of AEA, at 10 muM had a similar inhibitory effect to that of 100 muM AEA on Hcys-induced NLRP3 inflammasome formation and activation in cultured podocytes.	anandamide	155-158	NLR family, pyrin domain containing 3	Mus musculus	175-180
27189966-9	2016	We further demonstrated that prostaglandin E2-ethanolamide (PGE2-EA), a COX-2 product of AEA, at 10 muM had a similar inhibitory effect to that of 100 muM AEA on Hcys-induced NLRP3 inflammasome formation and activation in cultured podocytes.	Homocysteine	162-166	NLR family, pyrin domain containing 3	Mus musculus	175-180
27189966-10	2016	From these results, we conclude that AEA has anti-inflammatory properties, protecting podocytes from Hcys-induced injury by inhibition of NLRP3 inflammasome activation through its COX-2 metabolite, PGE2-EA.	anandamide	37-40	NLR family, pyrin domain containing 3	Mus musculus	138-143
29100270-0	2017	Albuminuria confers renal resistance to loop diuretics via the stimulation of NLRP3 inflammasome/prostaglandin signaling in thick ascending limb.	Prostaglandins	97-110	NLR family, pyrin domain containing 3	Mus musculus	78-83
29100270-4	2017	Meanwhile, NLRP3 and mPGES-1 were stimulated in NKCC2 positive tubules (thick ascending limb, TAL) paralleled with increased urinary PGE2 excretion.	Dinoprostone	133-137	NLR family, pyrin domain containing 3	Mus musculus	11-16
27321991-0	2016	Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis.	Dextran Sulfate	96-99	NLR family, pyrin domain containing 3	Mus musculus	68-73
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	NLR family, pyrin domain containing 3	Mus musculus	186-213
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	NLR family, pyrin domain containing 3	Mus musculus	215-220
27283237-4	2016	Administration of the specific NLRP3 inhibitor MCC950 to mice from one day following IAV challenge resulted in hypersusceptibility to lethality.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	47-53	NLR family, pyrin domain containing 3	Mus musculus	31-36
26921756-6	2016	Wogonoside inhibited the expression of hepatic NLRP3, ASC, caspase-1, and IL-1beta induced by LPS/GalN.	wogonoside	0-10	NLR family, pyrin domain containing 3	Mus musculus	47-52
26921756-7	2016	In conclusion, these results suggest that wogonoside protects against LPS/GalN-induced acute liver injury by activating Nrf2 and inhibiting NLRP3 inflammasome activation.	wogonoside	42-52	NLR family, pyrin domain containing 3	Mus musculus	140-145
27044804-0	2016	Inhibition of the Inflammasome NLRP3 by Arglabin Attenuates Inflammation, Protects Pancreatic beta-Cells from Apoptosis, and Prevents Type 2 Diabetes Mellitus Development in ApoE2Ki Mice on a Chronic High-Fat Diet.	arglabin	40-48	NLR family, pyrin domain containing 3	Mus musculus	31-36
27325457-0	2016	Enterococcus faecalis Lipoteichoic Acid-induced NLRP3 Inflammasome via the Activation of the Nuclear Factor Kappa B Pathway.	lipoteichoic acid	22-39	NLR family, pyrin domain containing 3	Mus musculus	48-53
27325457-1	2016	INTRODUCTION: We wished to examine the effects of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome on periapical periodontitis induced by Enterococcus faecalis and to investigate the molecular mechanisms of lipoteichoic acid (LTA) derived from E. faecalis on the expression of the NLRP3 inflammasome.	lipoteichoic acid	249-266	NLR family, pyrin domain containing 3	Mus musculus	121-126
27325457-1	2016	INTRODUCTION: We wished to examine the effects of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome on periapical periodontitis induced by Enterococcus faecalis and to investigate the molecular mechanisms of lipoteichoic acid (LTA) derived from E. faecalis on the expression of the NLRP3 inflammasome.	lipoteichoic acid	268-271	NLR family, pyrin domain containing 3	Mus musculus	121-126
26869350-7	2016	Knockdown Drp1 or gp91(phox) attenuated PA-induced NLRP3 induction and enhanced inhibitory effects of CRA.	Palmitates	40-42	NLR family, pyrin domain containing 3	Mus musculus	51-56
27225830-3	2016	Cardiac dysfunction and injury were induced by low-dose Dox (15 mg/kg) administration in NLRP3-deficient (NLRP3(-/-)) mice but not in wild-type (WT) and IL-1beta(-/-) mice, indicating that NLRP3 deficiency enhanced the susceptibility to Dox-induced cardiotoxicity independent of IL-1beta.	Doxorubicin	56-59	NLR family, pyrin domain containing 3	Mus musculus	89-94
27225830-3	2016	Cardiac dysfunction and injury were induced by low-dose Dox (15 mg/kg) administration in NLRP3-deficient (NLRP3(-/-)) mice but not in wild-type (WT) and IL-1beta(-/-) mice, indicating that NLRP3 deficiency enhanced the susceptibility to Dox-induced cardiotoxicity independent of IL-1beta.	Doxorubicin	56-59	NLR family, pyrin domain containing 3	Mus musculus	106-111
27225830-4	2016	Although the hearts of WT and NLRP3(-/-) mice showed no significant difference in inflammatory cell infiltration, macrophages were the predominant inflammatory cells in the hearts, and cardiac IL-10 production was decreased in Dox-treated NLRP3(-/-) mice.	Doxorubicin	227-230	NLR family, pyrin domain containing 3	Mus musculus	30-35
27225830-4	2016	Although the hearts of WT and NLRP3(-/-) mice showed no significant difference in inflammatory cell infiltration, macrophages were the predominant inflammatory cells in the hearts, and cardiac IL-10 production was decreased in Dox-treated NLRP3(-/-) mice.	Doxorubicin	227-230	NLR family, pyrin domain containing 3	Mus musculus	239-244
27225830-5	2016	Bone marrow transplantation experiments showed that bone marrow-derived cells contributed to the exacerbation of Dox-induced cardiotoxicity in NLRP3(-/-) mice.	Doxorubicin	113-116	NLR family, pyrin domain containing 3	Mus musculus	143-148
27225830-8	2016	These results demonstrated that NLRP3 regulates macrophage IL-10 production and contributes to the pathophysiology of Dox-induced cardiotoxicity, which is independent of IL-1beta.	Doxorubicin	118-121	NLR family, pyrin domain containing 3	Mus musculus	32-37
27225830-9	2016	Our findings identify a novel role of NLRP3 and provided new insights into the mechanisms underlying Dox-induced cardiotoxicity.	Doxorubicin	101-104	NLR family, pyrin domain containing 3	Mus musculus	38-43
27105502-7	2016	The underlying mechanisms for the protective effect of MALT1 inhibitors in DSS-induced colitis may be attributed to its inhibition on NF-kappaB and NLRP3 inflammasome activation in macrophages.	Dextran Sulfate	75-78	NLR family, pyrin domain containing 3	Mus musculus	148-153
26830216-15	2016	CONCLUSION: Artemisinin protects mice from burn sepsis by attenuating the inflammatory response and alleviating inflammatory infiltration in vital organs, likely through inhibiting the activation of NLRP3 inflammasome.	artemisinin	12-23	NLR family, pyrin domain containing 3	Mus musculus	199-204
26830216-0	2016	Artemisinin protects mice against burn sepsis through inhibiting NLRP3 inflammasome activation.	artemisinin	0-11	NLR family, pyrin domain containing 3	Mus musculus	65-70
26830216-13	2016	Artemisinin down-regulated protein levels of NLRP3 and caspase 1 and inhibited the increases of IL-1beta and IL-18 messenger RNA expression from Raw 264.7 cells that were stimulated with burn sepsis serum.	artemisinin	0-11	NLR family, pyrin domain containing 3	Mus musculus	45-50
26888116-0	2016	Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	62-67
26833024-0	2016	Correcting the NLRP3 inflammasome deficiency in macrophages from autoimmune NZB mice with exon skipping antisense oligonucleotides.	Oligonucleotides	114-130	NLR family, pyrin domain containing 3	Mus musculus	15-20
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides	42-58	NLR family, pyrin domain containing 3	Mus musculus	98-103
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides	42-58	NLR family, pyrin domain containing 3	Mus musculus	147-152
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides	42-58	NLR family, pyrin domain containing 3	Mus musculus	176-181
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides, Antisense	60-64	NLR family, pyrin domain containing 3	Mus musculus	98-103
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides, Antisense	60-64	NLR family, pyrin domain containing 3	Mus musculus	147-152
26833024-5	2016	Here we have used exon skipping antisense oligonucleotides (AONs) to prevent aberrant splicing of Nlrp3 in NZB macrophages, and this restored both NLRP3 protein expression and NLRP3 inflammasome activity.	Oligonucleotides, Antisense	60-64	NLR family, pyrin domain containing 3	Mus musculus	176-181
26888116-4	2016	How melatonin directly blocks activation of the NLRP3 inflammasome in ALI remains unclear.	Melatonin	4-13	NLR family, pyrin domain containing 3	Mus musculus	48-53
26888116-8	2016	Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone-induced NLRP3 inflammasome activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	41-46
26888116-8	2016	Melatonin inhibits the activation of the NLRP3 inflammasome by both suppressing the release of extracellular histones and directly blocking histone-induced NLRP3 inflammasome activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	156-161
27014913-0	2016	Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury.	Reactive Oxygen Species	14-37	NLR family, pyrin domain containing 3	Mus musculus	47-52
26349656-4	2016	Small intestinal damage developed 3 h after indomethacin administration, accompanied by increases in IL-1beta and NLRP3 mRNA expression and mature caspase-1 and IL-1beta levels.	Indomethacin	44-56	NLR family, pyrin domain containing 3	Mus musculus	114-119
26349656-9	2016	Apyrase, an adenosine triphosphate (ATP) scavenger, or Brilliant Blue G, a purinergic P2X7 receptor antagonist, inhibited the damage as well as caspase-1 activation and IL-1beta processing, despite there being sufficient amounts of pro-IL-1beta and NLRP3.	coomassie Brilliant Blue	55-71	NLR family, pyrin domain containing 3	Mus musculus	249-254
26896627-8	2016	NLRP3 myocardial expression was significantly increased at 24h and 6h vs 3h (P&lt;0.01).	6H	67-69	NLR family, pyrin domain containing 3	Mus musculus	0-5
26896627-8	2016	NLRP3 myocardial expression was significantly increased at 24h and 6h vs 3h (P&lt;0.01).	Tritium	73-75	NLR family, pyrin domain containing 3	Mus musculus	0-5
26896627-10	2016	The NLRP3inh given 1h after reperfusion also significantly decreased caspase-1 activity and infarct size measured at 24h, whereas the NLRP3inh did not when given with a delay of 3h.	Hydrogen	19-21	NLR family, pyrin domain containing 3	Mus musculus	4-9
26896627-11	2016	CONCLUSIONS: Pharmacological inhibition of the NLRP3 inflammasome within 1h of reperfusion limits the secondary inflammatory injury and infarct size following myocardial ischemia-reperfusion in the mouse.	Hydrogen	73-75	NLR family, pyrin domain containing 3	Mus musculus	47-52
27053298-0	2016	The caspase-1 inhibitor AC-YVAD-CMK attenuates acute gastric injury in mice: involvement of silencing NLRP3 inflammasome activities.	ac-yvad	24-31	NLR family, pyrin domain containing 3	Mus musculus	102-107
26980705-4	2016	HFD significantly enhanced the Asm activity, ceramide production, colocalization of Nlrp3 (Nod-like receptor protein 3) with ASC (apoptosis-associated speck-like protein) or Caspase-1, NADPH-dependent superoxide (O2( -)) production in glomeruli of Asm(+/+) mice than in control diet-fed mice.	Superoxides	201-211	NLR family, pyrin domain containing 3	Mus musculus	84-89
26980705-4	2016	HFD significantly enhanced the Asm activity, ceramide production, colocalization of Nlrp3 (Nod-like receptor protein 3) with ASC (apoptosis-associated speck-like protein) or Caspase-1, NADPH-dependent superoxide (O2( -)) production in glomeruli of Asm(+/+) mice than in control diet-fed mice.	Superoxides	213-215	NLR family, pyrin domain containing 3	Mus musculus	84-89
26980705-5	2016	However, such HFD-induced increases in Asm activity, ceramide production, colocalization of Nlrp3 with ASC or Caspase-1, superoxide (O(2 -)) production was attenuated in Asm(-/-) or Asm shRNA-transfected wild-type mice.	Superoxides	121-131	NLR family, pyrin domain containing 3	Mus musculus	92-97
27222180-7	2016	NAC obviously reduced cellular ROS level stimulated by PA (7782.15+-2.87 vs 5445.6+-1.17, P=0.00) and suppressed the expressions of NLRP3, ASC and caspase-1.	nac	0-3	NLR family, pyrin domain containing 3	Mus musculus	132-137
27075683-2	2016	Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver.	sulforaphane	58-70	NLR family, pyrin domain containing 3	Mus musculus	144-149
27075683-2	2016	Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver.	sulforaphane	72-75	NLR family, pyrin domain containing 3	Mus musculus	144-149
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	NLR family, pyrin domain containing 3	Mus musculus	46-51
27075683-5	2016	SFN inhibited saturated fatty acid-induced activation of the NLRP3 inflammasome in primary mouse hepatocytes, accompanied by the restoration of mitochondrial dysfunction.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	61-66
27075683-5	2016	SFN inhibited saturated fatty acid-induced activation of the NLRP3 inflammasome in primary mouse hepatocytes, accompanied by the restoration of mitochondrial dysfunction.	Fatty Acids	14-34	NLR family, pyrin domain containing 3	Mus musculus	61-66
27075683-6	2016	The suppression of NLRP3 inflammasome by SFN was mediated by the regulation of AMP-activated protein kinase-autophagy axis.	sulforaphane	41-44	NLR family, pyrin domain containing 3	Mus musculus	19-24
27053298-9	2016	Overall, our results showed that the caspase-1 inhibitor AC-YVAD-CMK protected against acute gastric injury in mice by affecting the NLRP3 inflammasome and attenuating inflammatory processes and apoptosis.	ac-yvad	57-64	NLR family, pyrin domain containing 3	Mus musculus	133-138
27014913-0	2016	Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury.	Aldosterone	92-103	NLR family, pyrin domain containing 3	Mus musculus	47-52
27014913-4	2016	The NLRP3 inflammasome is induced by Aldo in a dose- and time-dependent manner, as evidenced by increased NLRP3, ASC, caspase-1, and downstream cytokines, such as interleukin (IL)-1beta and IL-18.	Aldosterone	37-41	NLR family, pyrin domain containing 3	Mus musculus	4-9
27014913-4	2016	The NLRP3 inflammasome is induced by Aldo in a dose- and time-dependent manner, as evidenced by increased NLRP3, ASC, caspase-1, and downstream cytokines, such as interleukin (IL)-1beta and IL-18.	Aldosterone	37-41	NLR family, pyrin domain containing 3	Mus musculus	106-111
27014913-5	2016	The activation of the NLRP3 inflammasome was significantly prevented by the selective mineralocorticoid receptor (MR) antagonist eplerenone (EPL) (P &lt; 0.01).	Eplerenone	129-139	NLR family, pyrin domain containing 3	Mus musculus	22-27
27014913-9	2016	We conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS-mediated NLRP3 inflammasome activation.	Aldosterone	17-21	NLR family, pyrin domain containing 3	Mus musculus	101-106
27014913-9	2016	We conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS-mediated NLRP3 inflammasome activation.	Reactive Oxygen Species	88-91	NLR family, pyrin domain containing 3	Mus musculus	101-106
27010854-0	2016	Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.	poly-adp	0-8	NLR family, pyrin domain containing 3	Mus musculus	59-64
26639408-0	2016	Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	90-95
26639408-9	2016	Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), cleaved caspase-1, interleukin-1beta (IL-1beta), and interleukin-6 (IL-6); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2) and reduction in the pro-apoptotic factor (Bim).	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	45-50
26639408-10	2016	In summary, our results demonstrate that melatonin treatment attenuates the EBI following SAH by inhibiting NLRP3 inflammasome-associated apoptosis.	Melatonin	41-50	NLR family, pyrin domain containing 3	Mus musculus	108-113
26921636-0	2016	Dietary cholesterol promotes AOM-induced colorectal cancer through activating the NLRP3 inflammasome.	Cholesterol	8-19	NLR family, pyrin domain containing 3	Mus musculus	82-87
26921636-4	2016	Here we show that the cholesterol promoted colon carcinogenesis in azoxymethane (AOM)-treated mice through activating the NLRP3 inflammasome.	Cholesterol	22-33	NLR family, pyrin domain containing 3	Mus musculus	122-127
26921636-4	2016	Here we show that the cholesterol promoted colon carcinogenesis in azoxymethane (AOM)-treated mice through activating the NLRP3 inflammasome.	Azoxymethane	67-79	NLR family, pyrin domain containing 3	Mus musculus	122-127
26921636-4	2016	Here we show that the cholesterol promoted colon carcinogenesis in azoxymethane (AOM)-treated mice through activating the NLRP3 inflammasome.	Azoxymethane	81-84	NLR family, pyrin domain containing 3	Mus musculus	122-127
26921636-6	2016	Cholesterol crystals, detected in the colon of mice fed with HCD, also promoted NLRP3 inflammasome activation in macrophages, as indicated by elevated expression of cleaved caspase-1, formation of NLRP3-ASC-caspase-1 complex assembly, and higher IL-1beta secretion.	Cholesterol	0-11	NLR family, pyrin domain containing 3	Mus musculus	80-85
26921636-6	2016	Cholesterol crystals, detected in the colon of mice fed with HCD, also promoted NLRP3 inflammasome activation in macrophages, as indicated by elevated expression of cleaved caspase-1, formation of NLRP3-ASC-caspase-1 complex assembly, and higher IL-1beta secretion.	Cholesterol	0-11	NLR family, pyrin domain containing 3	Mus musculus	197-202
26921636-7	2016	Importantly, cholesterol was found to inhibit the activity of AMPKalpha in macrophages, leading to a significant production of mitochondrial ROS, which in turn activated the NLRP3 inflammasome.	Cholesterol	13-24	NLR family, pyrin domain containing 3	Mus musculus	174-179
26921636-7	2016	Importantly, cholesterol was found to inhibit the activity of AMPKalpha in macrophages, leading to a significant production of mitochondrial ROS, which in turn activated the NLRP3 inflammasome.	ros	141-144	NLR family, pyrin domain containing 3	Mus musculus	174-179
27062120-5	2016	In keeping with this, alum did not trigger IL-1beta production from human PMN, and the lysosomotropic peptide Leu-Leu-OMe stimulated only weak NLRP3-dependent IL-1beta production from murine neutrophils, suggesting that lysosomal rupture is not a strong stimulus for NLRP3 activation in neutrophils.	leucyl-leucine-methyl ester	110-121	NLR family, pyrin domain containing 3	Mus musculus	267-272
26639394-7	2016	We also found that uric acid-induced NLRP3 inflammasome activation, whereas lowering uric acid by allopurinol inhibited NLRP3 inflammasome activation in a high fat diet mouse model of NAFLD.	Uric Acid	19-28	NLR family, pyrin domain containing 3	Mus musculus	37-42
26639394-7	2016	We also found that uric acid-induced NLRP3 inflammasome activation, whereas lowering uric acid by allopurinol inhibited NLRP3 inflammasome activation in a high fat diet mouse model of NAFLD.	Uric Acid	85-94	NLR family, pyrin domain containing 3	Mus musculus	120-125
26639394-7	2016	We also found that uric acid-induced NLRP3 inflammasome activation, whereas lowering uric acid by allopurinol inhibited NLRP3 inflammasome activation in a high fat diet mouse model of NAFLD.	Allopurinol	98-109	NLR family, pyrin domain containing 3	Mus musculus	120-125
26931361-0	2016	Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia.	Proanthocyanidins	0-12	NLR family, pyrin domain containing 3	Mus musculus	71-76
26987023-7	2016	The CI treatment attenuated the intracellular movement of NLRP3 in Triton X-100 insoluble fraction, without affecting the expression of other NLRP3 inflammasome-related proteins.	Octoxynol	67-79	NLR family, pyrin domain containing 3	Mus musculus	58-63
26931361-0	2016	Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia.	Morphine	24-32	NLR family, pyrin domain containing 3	Mus musculus	71-76
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Morphine	28-36	NLR family, pyrin domain containing 3	Mus musculus	93-119
26931361-4	2016	Our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on NOD-like receptor protein3 (NLRP3) inflammasome in microglia.	Proanthocyanidins	87-99	NLR family, pyrin domain containing 3	Mus musculus	163-189
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Morphine	28-36	NLR family, pyrin domain containing 3	Mus musculus	121-126
26931361-4	2016	Our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on NOD-like receptor protein3 (NLRP3) inflammasome in microglia.	Proanthocyanidins	87-99	NLR family, pyrin domain containing 3	Mus musculus	191-196
26931361-12	2016	CONCLUSIONS: Procyanidins suppresses morphine-induced activation of NLRP3 inflammasome and inflammatory responses in microglia, and thus resulting in significant attenuation of morphine antinociceptive tolerance.	Proanthocyanidins	13-25	NLR family, pyrin domain containing 3	Mus musculus	68-73
26931361-4	2016	Our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on NOD-like receptor protein3 (NLRP3) inflammasome in microglia.	Morphine	113-121	NLR family, pyrin domain containing 3	Mus musculus	163-189
26931361-12	2016	CONCLUSIONS: Procyanidins suppresses morphine-induced activation of NLRP3 inflammasome and inflammatory responses in microglia, and thus resulting in significant attenuation of morphine antinociceptive tolerance.	Morphine	37-45	NLR family, pyrin domain containing 3	Mus musculus	68-73
26931361-12	2016	CONCLUSIONS: Procyanidins suppresses morphine-induced activation of NLRP3 inflammasome and inflammatory responses in microglia, and thus resulting in significant attenuation of morphine antinociceptive tolerance.	Morphine	177-185	NLR family, pyrin domain containing 3	Mus musculus	68-73
26931361-4	2016	Our present study investigated the effects and possible mechanism of a natural product procyanidins in improving morphine tolerance via its specific inhibition on NOD-like receptor protein3 (NLRP3) inflammasome in microglia.	Morphine	113-121	NLR family, pyrin domain containing 3	Mus musculus	191-196
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Proanthocyanidins	0-12	NLR family, pyrin domain containing 3	Mus musculus	93-119
26931361-10	2016	Procyanidins also inhibited morphine-induced increase of interleukin-1beta and activation of NOD-like receptor protein3 (NLRP3) inflammasome.	Proanthocyanidins	0-12	NLR family, pyrin domain containing 3	Mus musculus	121-126
26937141-0	2016	Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation.	Fatty Acids, Unsaturated	33-59	NLR family, pyrin domain containing 3	Mus musculus	86-113
26642356-3	2016	Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	183-206	NLR family, pyrin domain containing 3	Mus musculus	18-23
26642356-3	2016	Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	183-206	NLR family, pyrin domain containing 3	Mus musculus	101-106
26642356-3	2016	Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	208-211	NLR family, pyrin domain containing 3	Mus musculus	18-23
26642356-3	2016	Activation of the NLRP3 inflammasome required NEK7, which bound to the leucine-rich repeat domain of NLRP3 in a kinase-independent manner downstream of the induction of mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	208-211	NLR family, pyrin domain containing 3	Mus musculus	101-106
26642356-5	2016	NEK7 promoted the NLRP3-dependent cellular inflammatory response to intraperitoneal challenge with monosodium urate and the development of experimental autoimmune encephalitis in mice.	Uric Acid	99-115	NLR family, pyrin domain containing 3	Mus musculus	18-23
26681113-0	2016	Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.	Melatonin	108-117	NLR family, pyrin domain containing 3	Mus musculus	65-70
26681113-9	2016	Together, our results suggest that, although with different strengths, chronoinflammaging constitutes the biochemical substrate of aging and sepsis, and identifies the NLRP3 inflammasome as a new molecular target for melatonin, providing a rationale for its use in NLRP3-dependent diseases.	Melatonin	217-226	NLR family, pyrin domain containing 3	Mus musculus	168-173
26681113-9	2016	Together, our results suggest that, although with different strengths, chronoinflammaging constitutes the biochemical substrate of aging and sepsis, and identifies the NLRP3 inflammasome as a new molecular target for melatonin, providing a rationale for its use in NLRP3-dependent diseases.	Melatonin	217-226	NLR family, pyrin domain containing 3	Mus musculus	265-270
26623925-4	2016	A subgroup of HD-fed wild-type mice was treated with the NLRP3 inflammasome inhibitor BAY 11-7082 (3 mg/kg intraperitoneally [IP]).	3-(4-methylphenylsulfonyl)-2-propenenitrile	86-97	NLR family, pyrin domain containing 3	Mus musculus	57-62
26623925-8	2016	BAY 11-7082 also attenuated the diet-induced increase in NLRP3 inflammasome expression, resulting in inhibition of caspase-1 activation and interleukin (IL)-1beta and IL-18 production (in liver and kidney).	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	NLR family, pyrin domain containing 3	Mus musculus	57-62
26937141-0	2016	Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation.	dietary saturated fatty acid	0-28	NLR family, pyrin domain containing 3	Mus musculus	86-113
26937141-7	2016	SFA palmitic acid (PA) directly activated NLRP3 inflammasome and increased sensitization to LPS-induced inflammasome activation in hepatocytes.	sfa palmitic acid	0-17	NLR family, pyrin domain containing 3	Mus musculus	42-47
26937141-7	2016	SFA palmitic acid (PA) directly activated NLRP3 inflammasome and increased sensitization to LPS-induced inflammasome activation in hepatocytes.	Palmitic Acid	19-21	NLR family, pyrin domain containing 3	Mus musculus	42-47
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Fatty Acids, Unsaturated	13-17	NLR family, pyrin domain containing 3	Mus musculus	74-79
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Fatty Acids, Unsaturated	13-17	NLR family, pyrin domain containing 3	Mus musculus	152-157
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Docosahexaenoic Acids	18-38	NLR family, pyrin domain containing 3	Mus musculus	74-79
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Docosahexaenoic Acids	18-38	NLR family, pyrin domain containing 3	Mus musculus	152-157
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Docosahexaenoic Acids	40-43	NLR family, pyrin domain containing 3	Mus musculus	74-79
26937141-8	2016	In contrast, PUFA docosahexaenoic acid (DHA) had the potential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation.	Docosahexaenoic Acids	40-43	NLR family, pyrin domain containing 3	Mus musculus	152-157
26937141-9	2016	Furthermore, a high-fat diet increased but PUFA-enriched diet decreased sensitization to LPS-induced hepatic NLRP3 inflammasome activation in vivo.	Fatty Acids, Unsaturated	43-47	NLR family, pyrin domain containing 3	Mus musculus	109-114
26588861-0	2016	3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome.	3-(2-oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino(2,1-a)isoquinolin-4(11bH)-one	0-89	NLR family, pyrin domain containing 3	Mus musculus	189-194
26877061-2	2016	In the current study, we demonstrate that human and murine neutrophils express functional cell-surface P2X7R, which leads to ATP-induced loss of intracellular K(+), NLRP3 inflammasome activation and IL-1beta secretion.	Adenosine Triphosphate	125-128	NLR family, pyrin domain containing 3	Mus musculus	165-170
26683666-10	2016	These findings suggest that generation of reactive oxygen species and potassium efflux contribute to HIV-induced pyroptosis and NLRP3 inflammasome activation in podocytes.	Reactive Oxygen Species	42-65	NLR family, pyrin domain containing 3	Mus musculus	128-133
26683666-10	2016	These findings suggest that generation of reactive oxygen species and potassium efflux contribute to HIV-induced pyroptosis and NLRP3 inflammasome activation in podocytes.	Potassium	70-79	NLR family, pyrin domain containing 3	Mus musculus	128-133
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Salts	21-25	NLR family, pyrin domain containing 3	Mus musculus	132-137
26103560-7	2016	KEY RESULTS: 1K/DOCA/salt-induced hypertension in mice was associated with increased renal mRNA expression of inflammasome subunits NLRP3, ASC and pro-caspase-1, and the cytokine, pro-IL-1beta, as well as protein levels of active caspase-1 and mature IL-1beta.	Desoxycorticosterone Acetate	16-20	NLR family, pyrin domain containing 3	Mus musculus	132-137
26675345-5	2016	HCAG also reduced NLRP3 inflammasome-derived IL-1beta secretion by inhibiting the ATP-mediated phosphorylation of AKT and PKC-alpha/delta.	Adenosine Triphosphate	82-85	NLR family, pyrin domain containing 3	Mus musculus	18-23
26491791-7	2016	However, MLFE supplementation stimulated cutaneous NLRP3 inflammasome in HFD-induced obese mice (day 3).	mlfe	9-13	NLR family, pyrin domain containing 3	Mus musculus	51-56
26675345-0	2016	A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways.	cinnamaldehyde	25-39	NLR family, pyrin domain containing 3	Mus musculus	104-109
26555554-0	2016	Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	21-26
26555554-2	2016	Ethanol also activates other immune receptors, such as NOD-like-receptors, and specifically NLRP3-inflammasome in astroglial cells, to stimulate caspase-1 cleavage and IL-1beta and IL-18 cytokines production.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	92-97
26555554-4	2016	Using cerebral cortexes of the chronic alcohol-fed WT and TLR4(-/-) mice, we demonstrated that chronic ethanol treatment enhanced TLR4 mediated-NLRP3/Caspase-1 complex activation, and up-regulated pro-inflammatory cytokines and chemokines levels.	Ethanol	103-110	NLR family, pyrin domain containing 3	Mus musculus	144-149
26555554-5	2016	Ethanol-induced NLRP3-inflammasome activation and mitochondria-ROS generation were also observed in cultured microglial cells.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	16-21
26555554-8	2016	Thus, our results demonstrate that ethanol triggers TLR4-mediated NLRP3-inflammasome activation in glial cells, and suggest that microglia stimulation may compromise the permeability of blood-brain barrier events to contribute to ethanol-induced neuroinflammation and brain damage.	Ethanol	35-42	NLR family, pyrin domain containing 3	Mus musculus	66-71
26555554-8	2016	Thus, our results demonstrate that ethanol triggers TLR4-mediated NLRP3-inflammasome activation in glial cells, and suggest that microglia stimulation may compromise the permeability of blood-brain barrier events to contribute to ethanol-induced neuroinflammation and brain damage.	Ethanol	230-237	NLR family, pyrin domain containing 3	Mus musculus	66-71
26488087-0	2016	Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.	Hydrogen	10-18	NLR family, pyrin domain containing 3	Mus musculus	57-62
26488087-0	2016	Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species.	Reactive Oxygen Species	133-156	NLR family, pyrin domain containing 3	Mus musculus	57-62
26488087-2	2016	Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation that can be blocked by some mitochondria-targeted antioxidants.	Reactive Oxygen Species	42-65	NLR family, pyrin domain containing 3	Mus musculus	170-175
26488087-4	2016	Due to the unique molecular structure, H2 can easily target the mitochondria, suggesting that H2 is a potential antagonist of mtROS-dependent NLRP3 inflammasome activation.	Hydrogen	39-41	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-4	2016	Due to the unique molecular structure, H2 can easily target the mitochondria, suggesting that H2 is a potential antagonist of mtROS-dependent NLRP3 inflammasome activation.	Hydrogen	94-96	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-5	2016	Here we have showed that, in mouse macrophages, H2 exhibited substantial inhibitory activity against LPS-initiated NLRP3 inflammasome activation by scavenging mtROS.	Hydrogen	48-50	NLR family, pyrin domain containing 3	Mus musculus	115-120
26488087-6	2016	Moreover, the elimination of mtROS by H2 resultantly inhibited mtROS-mediated NLRP3 deubiquitination, a non-transcriptional priming signal of NLRP3 in response to the stimulation of LPS.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	78-83
26488087-6	2016	Moreover, the elimination of mtROS by H2 resultantly inhibited mtROS-mediated NLRP3 deubiquitination, a non-transcriptional priming signal of NLRP3 in response to the stimulation of LPS.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	142-147
26488087-7	2016	Additionally, the removal of mtROS by H2 reduced the generation of oxidized mitochondrial DNA and consequently decreased its binding to NLRP3, thereby inhibiting the NLRP3 inflammasome activation.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	136-141
26488087-7	2016	Additionally, the removal of mtROS by H2 reduced the generation of oxidized mitochondrial DNA and consequently decreased its binding to NLRP3, thereby inhibiting the NLRP3 inflammasome activation.	Hydrogen	38-40	NLR family, pyrin domain containing 3	Mus musculus	166-171
26488087-8	2016	Our findings have, for the first time, revealed the novel mechanism underlying the inhibitory effect of molecular hydrogen on LPS-caused NLRP3 inflammasome activation, highlighting the promising application of this new antioxidant in the treatment of LPS-associated inflammatory pathological damage.	Hydrogen	114-122	NLR family, pyrin domain containing 3	Mus musculus	137-142
26650800-7	2016	This study showed that magnesium lithospermate B could be used to treat acute and chronic colitis by inhibiting the activation of the NLRP3/ASC/Caspase-1 pathway.	magnesium lithospermate	23-46	NLR family, pyrin domain containing 3	Mus musculus	134-139
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	NLR family, pyrin domain containing 3	Mus musculus	238-243
26553871-5	2016	Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive.	Potassium	64-73	NLR family, pyrin domain containing 3	Mus musculus	38-43
26553871-5	2016	Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive.	Potassium	64-73	NLR family, pyrin domain containing 3	Mus musculus	97-102
26553871-5	2016	Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive.	Potassium	64-73	NLR family, pyrin domain containing 3	Mus musculus	97-102
26553871-7	2016	We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus.	Nigericin	94-103	NLR family, pyrin domain containing 3	Mus musculus	36-41
26553871-7	2016	We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus.	Potassium	109-118	NLR family, pyrin domain containing 3	Mus musculus	36-41
26449770-1	2016	Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation.	Uric Acid	99-115	NLR family, pyrin domain containing 3	Mus musculus	184-189
26449770-1	2016	Gout manifests as recurrent episodes of acute joint inflammation and pain due to the deposition of monosodium urate (MSU) crystals within the affected tissue in a process dependent on NLRP3 inflammasome activation.	Uric Acid	117-120	NLR family, pyrin domain containing 3	Mus musculus	184-189
26628639-0	2016	Suppression of NLRP3 inflammasome by gamma-tocotrienol ameliorates type 2 diabetes.	plastochromanol 8	37-54	NLR family, pyrin domain containing 3	Mus musculus	15-20
27610005-5	2016	Colitis was induced in wild-type (WT) and Nlrp3-/- mice by treatment with dextran sulphate sodium (DSS).	dextran sulphate sodium	74-97	NLR family, pyrin domain containing 3	Mus musculus	42-47
27010539-7	2016	In anesthetized mice, medullary infusion of Nlrp3 inflammasome activator, monosodium urate (MSU), induced significant decreases in sodium excretion and medullary blood flow without changes in mean arterial blood pressure and renal cortical blood flow.	Uric Acid	74-90	NLR family, pyrin domain containing 3	Mus musculus	44-49
27010539-7	2016	In anesthetized mice, medullary infusion of Nlrp3 inflammasome activator, monosodium urate (MSU), induced significant decreases in sodium excretion and medullary blood flow without changes in mean arterial blood pressure and renal cortical blood flow.	Uric Acid	92-95	NLR family, pyrin domain containing 3	Mus musculus	44-49
27010539-7	2016	In anesthetized mice, medullary infusion of Nlrp3 inflammasome activator, monosodium urate (MSU), induced significant decreases in sodium excretion and medullary blood flow without changes in mean arterial blood pressure and renal cortical blood flow.	Sodium	78-84	NLR family, pyrin domain containing 3	Mus musculus	44-49
27010539-8	2016	Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF.	Uric Acid	77-80	NLR family, pyrin domain containing 3	Mus musculus	49-54
27010539-8	2016	Caspase-1 inhibitor, Ac-YVAD-CMK and deletion of Nlrp3 or Asc gene abolished MSU-induced decreases in renal sodium excretion and MBF.	Sodium	108-114	NLR family, pyrin domain containing 3	Mus musculus	49-54
27010539-9	2016	CONCLUSION: Our results indicate that renal medullary Nlrp3 inflammasomes represent a new regulatory mechanism of renal MBF and sodium excretion which may not depend on classical inflammatory response.	Sodium	128-134	NLR family, pyrin domain containing 3	Mus musculus	54-59
27610005-5	2016	Colitis was induced in wild-type (WT) and Nlrp3-/- mice by treatment with dextran sulphate sodium (DSS).	dss	99-102	NLR family, pyrin domain containing 3	Mus musculus	42-47
27610005-7	2016	DSS-treated Nlrp3-/- mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17.	dss	0-3	NLR family, pyrin domain containing 3	Mus musculus	12-17
28104929-10	2016	Also, reduced production of IL-1beta, IL-18, NLRP3 protein, and mitochondrial ROS in the aortic tissues was detected with dapagliflozin treatment.	dapagliflozin	122-135	NLR family, pyrin domain containing 3	Mus musculus	45-50
27143817-7	2016	Moreover, LPS-induced NLRP3 inflammasome and cleaved caspase-1 were inhibited by rolipram.	Rolipram	81-89	NLR family, pyrin domain containing 3	Mus musculus	22-27
28104929-11	2016	In vitro, NLRP3 inflammasome was activated by hyperglucose and hyperlipid through ROS pathway.	hyperglucose	46-58	NLR family, pyrin domain containing 3	Mus musculus	10-15
28104929-11	2016	In vitro, NLRP3 inflammasome was activated by hyperglucose and hyperlipid through ROS pathway.	hyperlipid	63-73	NLR family, pyrin domain containing 3	Mus musculus	10-15
28104929-11	2016	In vitro, NLRP3 inflammasome was activated by hyperglucose and hyperlipid through ROS pathway.	Reactive Oxygen Species	82-85	NLR family, pyrin domain containing 3	Mus musculus	10-15
28104929-13	2016	Dapagliflozin may be of therapeutic potential for diabetic atherosclerosis induced by high-fat diet, and these benefits may depend on the inhibitory effect on the secretion of IL-1beta by macrophages via the ROS-NLRP3-caspase-1 pathway.	dapagliflozin	0-13	NLR family, pyrin domain containing 3	Mus musculus	212-217
28104929-13	2016	Dapagliflozin may be of therapeutic potential for diabetic atherosclerosis induced by high-fat diet, and these benefits may depend on the inhibitory effect on the secretion of IL-1beta by macrophages via the ROS-NLRP3-caspase-1 pathway.	Reactive Oxygen Species	208-211	NLR family, pyrin domain containing 3	Mus musculus	212-217
26924896-0	2016	Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1beta Axis in Microglia.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	79-84
26924896-9	2016	NLRP3 expression and IL-1beta cleavage were well inhibited by resveratrol dose-dependently.	Resveratrol	62-73	NLR family, pyrin domain containing 3	Mus musculus	0-5
26924896-10	2016	The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide.	Resveratrol	55-66	NLR family, pyrin domain containing 3	Mus musculus	88-93
26924896-10	2016	The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide.	Adenosine Triphosphate	76-79	NLR family, pyrin domain containing 3	Mus musculus	88-93
26924896-10	2016	The in vitro results showed that in the BV2 cell lines resveratrol prevents ATP induced NLRP3 activation and IL-1beta cleavage, which were reversed by the sirtuin 1 inhibitor, nicotinamide.	Niacinamide	176-188	NLR family, pyrin domain containing 3	Mus musculus	88-93
26924896-11	2016	In conclusion, resveratrol improves the spatial memory in mice with SAE and inhibits the NLRP3/IL-1beta axis in the microglia.	Resveratrol	15-26	NLR family, pyrin domain containing 3	Mus musculus	89-94
27846628-0	2016	Minocycline Suppresses NLRP3 Inflammasome Activation in Experimental Ischemic Stroke.	Minocycline	0-11	NLR family, pyrin domain containing 3	Mus musculus	23-28
27433030-0	2016	Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.	hydroxysafflor yellow A	0-23	NLR family, pyrin domain containing 3	Mus musculus	45-50
27433030-1	2016	Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated.	hydroxysafflor yellow A	0-23	NLR family, pyrin domain containing 3	Mus musculus	151-156
27433030-6	2016	These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1beta secretion in macrophages.	ros	149-152	NLR family, pyrin domain containing 3	Mus musculus	199-204
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	NLR family, pyrin domain containing 3	Mus musculus	237-242
27846628-3	2016	METHODS: We investigated the effects of minocycline on NLRP3 inflammasome activation using the transient middle cerebral artery occlusion (tMCAO) mouse model and an in vitro oxygen-glucose deprivation/reoxygenation injury model in BV2 microglial cells.	Minocycline	40-51	NLR family, pyrin domain containing 3	Mus musculus	55-60
27846628-2	2016	Since NLRP3 inflammasome activation controls the maturation and release of proinflammatory cytokines, especially interleukin-1beta (IL-1beta) and IL-18 in ischemia stroke, we suppose that minocycline may be involved in the regulation of NLRP3 inflammasome activation.	Minocycline	188-199	NLR family, pyrin domain containing 3	Mus musculus	6-11
27846628-5	2016	Meanwhile, we showed that minocycline prevented the activation of microglias and attenuated NLRP3 inflammasome signaling after tMCAO injury.	Minocycline	26-37	NLR family, pyrin domain containing 3	Mus musculus	92-97
27846628-6	2016	Furthermore, we found that the pretreatment of minocycline significantly inhibited signal 1 and signal 2 of NLRP3 inflammasome activation in BV2 cells.	Minocycline	47-58	NLR family, pyrin domain containing 3	Mus musculus	108-113
26081624-0	2015	Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1beta Mechanism.	Diphosphonates	0-14	NLR family, pyrin domain containing 3	Mus musculus	69-74
27846628-7	2016	CONCLUSION: We demonstrated that minocycline can ameliorate ischemia-induced brain damage via inhibiting NLRP3 inflammasome activation.	Minocycline	33-44	NLR family, pyrin domain containing 3	Mus musculus	105-110
27847555-0	2016	Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	101-106
26438821-4	2015	Given that the metabolic fate of fatty acids in macrophages is not entirely elucidated, we have hypothesized that de novo synthesis of ceramide, through the rate-limiting enzyme serine palmitoyltransferase long chain (Sptlc)-2, is required for saturated fatty acid-driven Nlrp3 inflammasome activation in macrophages.	Ceramides	135-143	NLR family, pyrin domain containing 3	Mus musculus	272-277
27843532-0	2016	NLRP3 Inflammasome Activation in the Brain after Global Cerebral Ischemia and Regulation by 17beta-Estradiol.	Estradiol	92-108	NLR family, pyrin domain containing 3	Mus musculus	0-5
26438821-5	2015	Here we report that mitochondrial targeted overexpression of catalase, which is established to mitigate oxidative stress, controls ceramide-induced Nlrp3 inflammasome activation but does not affect the ATP-mediated caspase-1 cleavage.	Ceramides	131-139	NLR family, pyrin domain containing 3	Mus musculus	148-153
26635145-0	2015	Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation.	Busulfan	0-8	NLR family, pyrin domain containing 3	Mus musculus	61-66
26635145-0	2015	Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation.	cyclosphamide	13-26	NLR family, pyrin domain containing 3	Mus musculus	61-66
26635145-1	2015	The aim of this study was to evaluate the role of NLRP3 inflammasome on BU/CY-induced liver inflammation in mice after HSCT.	Cysteine	75-77	NLR family, pyrin domain containing 3	Mus musculus	50-55
26635145-4	2015	Furthermore, NLRP3 selective inhibitor (BAY 11-7082) was administrated into mice after HSCT to evaluate its effects on liver inflammation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	40-51	NLR family, pyrin domain containing 3	Mus musculus	13-18
26635145-10	2015	In conclusion, NLRP3 was involved in BU/CY-induced liver inflammation after HSCT and selectively inhibited it ameliorated liver inflammation and improved liver function, suggesting targeting NLRP3 might be a new approach in the prophylaxis of liver inflammation after HSCT.	Busulfan	37-39	NLR family, pyrin domain containing 3	Mus musculus	15-20
26635145-10	2015	In conclusion, NLRP3 was involved in BU/CY-induced liver inflammation after HSCT and selectively inhibited it ameliorated liver inflammation and improved liver function, suggesting targeting NLRP3 might be a new approach in the prophylaxis of liver inflammation after HSCT.	Busulfan	37-39	NLR family, pyrin domain containing 3	Mus musculus	191-196
26635145-10	2015	In conclusion, NLRP3 was involved in BU/CY-induced liver inflammation after HSCT and selectively inhibited it ameliorated liver inflammation and improved liver function, suggesting targeting NLRP3 might be a new approach in the prophylaxis of liver inflammation after HSCT.	Cysteine	40-42	NLR family, pyrin domain containing 3	Mus musculus	15-20
26635145-10	2015	In conclusion, NLRP3 was involved in BU/CY-induced liver inflammation after HSCT and selectively inhibited it ameliorated liver inflammation and improved liver function, suggesting targeting NLRP3 might be a new approach in the prophylaxis of liver inflammation after HSCT.	Cysteine	40-42	NLR family, pyrin domain containing 3	Mus musculus	191-196
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Zoledronic Acid	32-43	NLR family, pyrin domain containing 3	Mus musculus	135-140
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Zoledronic Acid	45-48	NLR family, pyrin domain containing 3	Mus musculus	135-140
26081624-8	2015	Systemic treatment of mice with zoledronate (Zol), a nitrogen-containing bisphosphonate, resulted in a 1.86- and 1.63-fold increase in NLRP3/caspase-1-dependent IL-1beta secretion by db/+ and db/db BMDMs, respectively, compared with BMDMs derived from nontreated mice (p &lt; 0.001).	Diphosphonates	73-87	NLR family, pyrin domain containing 3	Mus musculus	135-140
26584539-9	2015	CONCLUSION: Our data show that Citral alleviates the mouse ASLN model by inhibition of the activation signal, but not the priming signal, of NLRP3 inflammasome and enhanced activation of Nrf2 antioxidant signaling.	citral	31-37	NLR family, pyrin domain containing 3	Mus musculus	141-146
26293846-8	2015	Taken together, these data strongly suggest that the activation of endothelial Nlrp3 inflammasomes as a result of the increased actions of injurious adipokines such as visfatin produces HMGB1, which act in paracrine or autocrine fashion to disrupt inter-endothelial junctions and increase paracellular permeability of the endothelium contributing to the early onset of endothelial injury during metabolic disorders such as obesity or high-fat/cholesterol diet.	Cholesterol	443-454	NLR family, pyrin domain containing 3	Mus musculus	79-84
26660560-6	2015	Asbestos-exposed mice displayed an increased innate immune response consistent with NLRP3 inflammasome activation.	Asbestos	0-8	NLR family, pyrin domain containing 3	Mus musculus	84-89
26611836-5	2015	Treatment of hyperoxia-exposed mice with either IL1 receptor antagonist to block IL1beta or glyburide to block the Nlrp3 inflammasome results in decreased inflammation and increased alveolarization.	Glyburide	92-101	NLR family, pyrin domain containing 3	Mus musculus	115-120
26454213-6	2015	We further found that GE treatment reversed CUMS-induced IL-1beta elevation, possibly by inhibiting nuclear factor kappa B (NF-kappaB) pathway activation and regulating nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome expression.	cums	44-48	NLR family, pyrin domain containing 3	Mus musculus	263-268
26584539-0	2015	Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation.	citral	0-6	NLR family, pyrin domain containing 3	Mus musculus	105-110
26584539-5	2015	The analysis of mechanisms of action of Citral also involved its effects on IL-1beta secretion and signaling pathways of NLRP3 inflammasome in LPS-primed peritoneal macrophages or J774A macrophages.	citral	40-46	NLR family, pyrin domain containing 3	Mus musculus	121-126
26584539-7	2015	In addition, Citral inhibited NLRP3 inflammasome activation and levels of ROS, NAD(P)H oxidase subunit p47(phox), or COX-2, and it enhanced the activation of nuclear factor E2-related factor 2 (Nrf2).	citral	13-19	NLR family, pyrin domain containing 3	Mus musculus	30-35
26529046-7	2015	RESULTS: Intravitreous injection of 3TC, AZT, and ABC significantly suppressed laser-induced CNV in C57BL/6J wild-type and Nlrp3-/- mice (P &lt; 0.05) but not in P2rx7-/- mice.	Lamivudine	36-39	NLR family, pyrin domain containing 3	Mus musculus	123-128
24914072-0	2015	Gadolinium-based compounds induce NLRP3-dependent IL-1beta production and peritoneal inflammation.	Gadolinium	0-10	NLR family, pyrin domain containing 3	Mus musculus	34-39
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	Silicon Dioxide	42-48	NLR family, pyrin domain containing 3	Mus musculus	148-153
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	Asbestos	52-60	NLR family, pyrin domain containing 3	Mus musculus	148-153
24914072-4	2015	Because other profibrotic agents, such as silica or asbestos, activate the nucleotide-binding oligomerisation domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and initiate interleukin (IL)-1beta release with the subsequent development of fibrosis, we evaluated the effects of GBCAs on inflammasome activation.	gbcas	285-290	NLR family, pyrin domain containing 3	Mus musculus	148-153
26250869-0	2015	Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	20-25
26250869-6	2015	The inhibition of NLRP3 inflammasome by curcumin was in part mediated via the suppression of extracellular regulated protein kinases phosphorylation.	Curcumin	40-48	NLR family, pyrin domain containing 3	Mus musculus	18-23
26250869-3	2015	Here, we sought to investigate the role and mechanism of curcumin on the inhibition of mature IL-1beta production via the regulation of NLRP3 inflammasome.	Curcumin	57-65	NLR family, pyrin domain containing 3	Mus musculus	136-141
26250869-8	2015	CONCLUSION: Curcumin potently inhibits the activation of NLRP3 inflammasome which may contribute to its anti-inflammatory activity.	Curcumin	12-20	NLR family, pyrin domain containing 3	Mus musculus	57-62
26250869-9	2015	Our finding offers a mechanistic basis for the therapeutic potential of curcumin in septic shock and other NLRP3 inflammasome-driven diseases.	Curcumin	72-80	NLR family, pyrin domain containing 3	Mus musculus	107-112
26250869-4	2015	METHODS AND RESULTS: Curcumin dramatically inhibited the production of mature IL-1beta in LPS-primed macrophages triggered by multiple NLRP3 inflammasome activators, and also reduced the level of cleaved caspase-1 as measured by western blot and ELISA.	Curcumin	21-29	NLR family, pyrin domain containing 3	Mus musculus	135-140
26250869-5	2015	Curcumin prevented K(+) efflux, the common trigger for NLRP3 inflammasome activation, and attenuated lysosomes disruption and intracellular ROS formation as well.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	55-60
26770363-0	2015	Isoflurane attenuates murine lupus nephritis by inhibiting NLRP3 inflammasome activation.	Isoflurane	0-10	NLR family, pyrin domain containing 3	Mus musculus	59-64
26489382-4	2015	Conversely, carbonyl cyanide m-chlorophenyl hydrazone, a chemical inducer of mitochondrial fission, clearly attenuated NLRP3 inflammasome assembly and activation.	Carbonyl Cyanide m-Chlorophenyl Hydrazone	12-53	NLR family, pyrin domain containing 3	Mus musculus	119-124
25974041-0	2015	Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.	nicotinamide-beta-riboside	0-21	NLR family, pyrin domain containing 3	Mus musculus	71-76
26361146-8	2015	Tunicamycin-exposed islets from NLRP3 KO mice exhibited similar levels of ER stress and apoptosis induction as islets from WT (Ins2(+/+); NLRP3(+/+)) mice.	Tunicamycin	0-11	NLR family, pyrin domain containing 3	Mus musculus	32-37
26320672-0	2015	Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition.	fumigaclavine C	0-15	NLR family, pyrin domain containing 3	Mus musculus	91-96
26086368-0	2015	Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia.	Rifampin	0-10	NLR family, pyrin domain containing 3	Mus musculus	68-73
26086368-0	2015	Rifampicin attenuates rotenone-induced inflammation via suppressing NLRP3 inflammasome activation in microglia.	Rotenone	22-30	NLR family, pyrin domain containing 3	Mus musculus	68-73
26086368-7	2015	Moreover, western blot analysis verified that rifampicin pretreatment suppressed NLRP3 inflammasome activation via inhibiting caspase-1 cleavage and protein expression of NLRP3.	Rifampin	46-56	NLR family, pyrin domain containing 3	Mus musculus	81-86
26086368-7	2015	Moreover, western blot analysis verified that rifampicin pretreatment suppressed NLRP3 inflammasome activation via inhibiting caspase-1 cleavage and protein expression of NLRP3.	Rifampin	46-56	NLR family, pyrin domain containing 3	Mus musculus	171-176
26086368-8	2015	As it is indicated that reactive oxidative stress (ROS) is one of the activators for NLRP3 inflammasome, we further employed 2",7"-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining and Rhodamine123 staining to detect intracellular ROS and mitochondrial membrane potential (MMP), respectively.	ros	51-54	NLR family, pyrin domain containing 3	Mus musculus	85-90
26086368-10	2015	Taken together, our data indicate that rifampicin pretreatment inhibits maturation of IL-1beta and neuroinflammation induced by rotenone via attenuating NLRP3 inflammasome activation.	Rifampin	39-49	NLR family, pyrin domain containing 3	Mus musculus	153-158
26086368-10	2015	Taken together, our data indicate that rifampicin pretreatment inhibits maturation of IL-1beta and neuroinflammation induced by rotenone via attenuating NLRP3 inflammasome activation.	Rotenone	128-136	NLR family, pyrin domain containing 3	Mus musculus	153-158
26320672-0	2015	Fumigaclavine C ameliorates dextran sulfate sodium-induced murine experimental colitis via NLRP3 inflammasome inhibition.	Dextran Sulfate	28-50	NLR family, pyrin domain containing 3	Mus musculus	91-96
26320672-5	2015	At the same time, decreased activation of caspase-1 in peritoneal macrophages was detected in Fumigaclavine C -treated mice which suggested that the NLRP3 inflammasome activation was suppressed.	fumigaclavine C	94-109	NLR family, pyrin domain containing 3	Mus musculus	149-154
26320672-7	2015	Taken together, our results demonstrate the ability of Fumigaclavine C to inhibit NLRP3 inflammasome activation and give some evidence for its potential use in the treatment of inflammatory bowel diseases.	fumigaclavine C	55-70	NLR family, pyrin domain containing 3	Mus musculus	82-87
26379247-8	2015	Mechanistically, SS-31 treatment suppressed pro-inflammatory responses by decreasing the levels of NF-kappaB, NLRP3, caspase 1, IL-1beta, and TNF-alpha; and inhibited the apoptotic pathway by decreasing the Bax/Bcl-2 ratio, reducing the release of cytochrome C, and blocking the cleavage of caspase 3.	arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide	17-22	NLR family, pyrin domain containing 3	Mus musculus	110-115
26166692-7	2015	These results suggest that PLIN2 inhibits insulin-induced glucose uptake by activating NLRP3, caspase-1 and IL-1beta, leading to a decreased IRS-1 expression.	Glucose	58-65	NLR family, pyrin domain containing 3	Mus musculus	87-92
26367131-6	2015	The quick release of reactive oxygen species (ROS) by the infected macrophages suggests a plausible viral initiation of NLRP3 inflammasome activation.	Reactive Oxygen Species	21-44	NLR family, pyrin domain containing 3	Mus musculus	120-125
26367131-6	2015	The quick release of reactive oxygen species (ROS) by the infected macrophages suggests a plausible viral initiation of NLRP3 inflammasome activation.	Reactive Oxygen Species	46-49	NLR family, pyrin domain containing 3	Mus musculus	120-125
26367131-7	2015	Further experiments show that mice deficient of p47phox, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit that controls acute ROS production, present with reductions in NLRP3 inflammasome activation and subsequent IL-1beta secretion during viral infection, which appears to be responsible for acquiring resilience to viral FH.	Reactive Oxygen Species	147-150	NLR family, pyrin domain containing 3	Mus musculus	190-195
26045547-0	2015	Disruption of the NF-kappaB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-alpha and blocks the septic response in mice.	Melatonin	48-57	NLR family, pyrin domain containing 3	Mus musculus	28-33
26045547-5	2015	Melatonin also decreased NF-kappaB-dependent proinflammatory response and restored redox balance and mitochondrial homeostasis, thus inhibiting the NLRP3 inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	148-153
26045547-7	2015	Our results are evidence of the NF-kappaB/NLRP3 connection during sepsis and identify NLRP3 as a novel molecular target for melatonin.	Melatonin	124-133	NLR family, pyrin domain containing 3	Mus musculus	42-47
26045547-7	2015	Our results are evidence of the NF-kappaB/NLRP3 connection during sepsis and identify NLRP3 as a novel molecular target for melatonin.	Melatonin	124-133	NLR family, pyrin domain containing 3	Mus musculus	86-91
26100631-3	2015	Sustained stimulation (&gt;2 h) of LPS-primed caspase-1-deficient (Casp1/11(-/-)) BMDC with the canonical NLRP3 inflammasome agonist nigericin results in release of bioactive IL-1beta in conjunction with robust caspase-8 activation.	Nigericin	133-142	NLR family, pyrin domain containing 3	Mus musculus	106-111
26195813-4	2015	Prior studies have found that the cathepsin B inhibitor, Ca074Me, suppresses this response, supporting a model whereby ingested particles disrupt lysosomes and release cathepsin B into the cytosol, somehow activating NLRP3.	CA 074 methyl ester	57-64	NLR family, pyrin domain containing 3	Mus musculus	217-222
26119225-0	2015	NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure.	Oxygen	56-62	NLR family, pyrin domain containing 3	Mus musculus	0-5
26119225-0	2015	NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure.	Paraquat	133-141	NLR family, pyrin domain containing 3	Mus musculus	0-5
26119225-5	2015	Interestingly, activation of NLRP3 inflammasome, which triggers inflammation in response to mitochondrial stress, was enhanced in paraquat-exposed mice.	Paraquat	130-138	NLR family, pyrin domain containing 3	Mus musculus	29-34
26119225-7	2015	Together, our results indicate that NLRP3 inflammasome activation induced by mitochondrial reactive oxygen species plays a key role in mediating paraquat-induced long-term cognition decline by elevating brain inflammation.	Oxygen	100-106	NLR family, pyrin domain containing 3	Mus musculus	36-41
26119225-7	2015	Together, our results indicate that NLRP3 inflammasome activation induced by mitochondrial reactive oxygen species plays a key role in mediating paraquat-induced long-term cognition decline by elevating brain inflammation.	Paraquat	145-153	NLR family, pyrin domain containing 3	Mus musculus	36-41
26100631-5	2015	In contrast to the rapid caspase-1-mediated death of wild type (WT) BMDC via NLRP3-dependent pyroptosis, nigericin-stimulated Casp1/11(-/-) BMDC exhibit markedly delayed cell death via NLRP3-dependent apoptosis.	Nigericin	105-114	NLR family, pyrin domain containing 3	Mus musculus	185-190
25601272-5	2015	Upon lipopolysaccharide (LPS) or LPS/ATP stimulation, IL-4 markedly inhibited the assembly of NLRP3 inflammasome, including NLRP3-dependent ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomerization, NLRP3-ASC interaction and NLRP3 speck-like oligomeric structure formation.	Adenosine Triphosphate	37-40	NLR family, pyrin domain containing 3	Mus musculus	94-99
30338301-0	2015	Cellulose nanocrystal cationic derivative induces NLRP3 inflammasome-dependent IL-1beta secretion associated with mitochondrial ROS production.	Cellulose	0-9	NLR family, pyrin domain containing 3	Mus musculus	50-55
30338301-0	2015	Cellulose nanocrystal cationic derivative induces NLRP3 inflammasome-dependent IL-1beta secretion associated with mitochondrial ROS production.	Reactive Oxygen Species	128-131	NLR family, pyrin domain containing 3	Mus musculus	50-55
25975512-6	2015	ATP, nigericin and MSU were used as danger-associated molecules to activate the NLRP3 inflammasome.	Adenosine Triphosphate	0-3	NLR family, pyrin domain containing 3	Mus musculus	80-85
25975512-6	2015	ATP, nigericin and MSU were used as danger-associated molecules to activate the NLRP3 inflammasome.	Nigericin	5-14	NLR family, pyrin domain containing 3	Mus musculus	80-85
26086107-0	2015	Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS.	Ginsenosides	0-11	NLR family, pyrin domain containing 3	Mus musculus	49-54
26086107-3	2015	In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression.	Ginsenosides	36-48	NLR family, pyrin domain containing 3	Mus musculus	159-164
26086107-3	2015	In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression.	Nitric Oxide	192-204	NLR family, pyrin domain containing 3	Mus musculus	159-164
26086107-4	2015	In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1beta production via the S-nitrosylation of the NLRP3 inflammasome.	Nitric Oxide	91-103	NLR family, pyrin domain containing 3	Mus musculus	275-280
26234821-0	2015	Sodium butyrate alleviates adipocyte inflammation by inhibiting NLRP3 pathway.	Butyric Acid	0-15	NLR family, pyrin domain containing 3	Mus musculus	64-69
26234821-10	2015	Further analysis of inflammation pathway showed that NLRP3 was activated in db/db mice, which was efficiently inhibited by NaB treatment.	nab	123-126	NLR family, pyrin domain containing 3	Mus musculus	53-58
25601272-5	2015	Upon lipopolysaccharide (LPS) or LPS/ATP stimulation, IL-4 markedly inhibited the assembly of NLRP3 inflammasome, including NLRP3-dependent ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomerization, NLRP3-ASC interaction and NLRP3 speck-like oligomeric structure formation.	Adenosine Triphosphate	37-40	NLR family, pyrin domain containing 3	Mus musculus	124-129
25937482-6	2015	P2X7 antagonist A438079 suppressed NLRP3/ASC/caspase 1 activation, production of IL-1beta, IL-17A and IFN-gamma and neutrophil infiltration but not the production of IL-10, resulting in a significant amelioration of lung injury.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	16-23	NLR family, pyrin domain containing 3	Mus musculus	35-40
25601272-5	2015	Upon lipopolysaccharide (LPS) or LPS/ATP stimulation, IL-4 markedly inhibited the assembly of NLRP3 inflammasome, including NLRP3-dependent ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomerization, NLRP3-ASC interaction and NLRP3 speck-like oligomeric structure formation.	Adenosine Triphosphate	37-40	NLR family, pyrin domain containing 3	Mus musculus	124-129
25601272-5	2015	Upon lipopolysaccharide (LPS) or LPS/ATP stimulation, IL-4 markedly inhibited the assembly of NLRP3 inflammasome, including NLRP3-dependent ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain) oligomerization, NLRP3-ASC interaction and NLRP3 speck-like oligomeric structure formation.	Adenosine Triphosphate	37-40	NLR family, pyrin domain containing 3	Mus musculus	124-129
25601272-8	2015	Furthermore, the IL-4-mediated suppression of NLRP3 inflammasome was independent of STAT6-dependent transcription and mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	132-155	NLR family, pyrin domain containing 3	Mus musculus	46-51
25601272-8	2015	Furthermore, the IL-4-mediated suppression of NLRP3 inflammasome was independent of STAT6-dependent transcription and mitochondrial reactive oxygen species (ROS).	Reactive Oxygen Species	157-160	NLR family, pyrin domain containing 3	Mus musculus	46-51
26074074-0	2015	Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.	Iron	0-4	NLR family, pyrin domain containing 3	Mus musculus	53-58
25915511-5	2015	In the doxorubicin model, a significant increase in myocardial interstitial fibrosis and a decline in systolic function were seen in vehicle-treated mice, whereas treatment with the NLRP3 inhibitor significantly reduced fibrosis (-80%, P = 0.001) and preserved systolic function (LVFS 35 +- 2 vs. vehicle 27% +- 2%, P = 0.017).	Doxorubicin	7-18	NLR family, pyrin domain containing 3	Mus musculus	182-187
25914040-13	2015	Additionally, Wuling San decreased NLRP3 inflammasome activation and IL-1beta secretion in the kidney of fructose-fed mice.	Fructose	105-113	NLR family, pyrin domain containing 3	Mus musculus	35-40
25914040-15	2015	The molecular mechanism of its action may be associated with the suppression of TLR4/MyD88 signaling and NLRP3 inflammasome activation to reduce IL-1beta production in high fructose-induced hyperuricemic mice.	Fructose	173-181	NLR family, pyrin domain containing 3	Mus musculus	105-110
25535911-0	2015	Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	21-26
25535911-2	2015	Here, we report that resveratrol, a polyphenolic compound naturally produced by plants, inhibits NLRP3 inflammasome-derived IL-1beta secretion and pyroptosis in macrophages.	Resveratrol	21-32	NLR family, pyrin domain containing 3	Mus musculus	97-102
25535911-3	2015	Resveratrol inhibits the activation step of the NLRP3 inflammasome by suppressing mitochondrial damage.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	48-53
25535911-7	2015	Our data indicate that resveratrol suppresses NLRP3 inflammasome activation by preserving mitochondrial integrity and by augmenting autophagy.	Resveratrol	23-34	NLR family, pyrin domain containing 3	Mus musculus	46-51
25937574-0	2015	L-Menthone confers antidepressant-like effects in an unpredictable chronic mild stress mouse model via NLRP3 inflammasome-mediated inflammatory cytokines and central neurotransmitters.	menthone	0-10	NLR family, pyrin domain containing 3	Mus musculus	103-108
26074074-3	2015	We report that excess iron, but not other Fenton catalytic metals, induces activation of the NLRP3 inflammasome, a pathway also implicated in AMD.	Iron	22-26	NLR family, pyrin domain containing 3	Mus musculus	93-98
26074074-4	2015	Additionally, iron-induced degeneration of the retinal pigmented epithelium (RPE) is suppressed in mice lacking inflammasome components caspase-1/11 or Nlrp3 or by inhibition of caspase-1.	Iron	14-18	NLR family, pyrin domain containing 3	Mus musculus	152-157
25929180-0	2015	Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages.	Ziram	81-86	NLR family, pyrin domain containing 3	Mus musculus	72-77
25929180-2	2015	Here, we found that the treatment of mouse macrophages with the zinc-containing dithiocarbamate ziram, a widely used fungicide in agriculture, caused a decrease in pro-caspase-1 and NLRP3 levels while not affecting ASC level.	dithiocarbamate ziram	80-101	NLR family, pyrin domain containing 3	Mus musculus	182-187
25929180-6	2015	Furthermore, the zinc-containing dithiocarbamate, zinc diethyldithiocarbamate, efficiently decreased the levels of pro-caspase-1 and NLRP3, whereas dithiocarbamates, dimethyldithiocarbamate and diethyldithiocarbamate without zinc, were less active.	Dithiocarbamate	33-48	NLR family, pyrin domain containing 3	Mus musculus	133-138
25929180-6	2015	Furthermore, the zinc-containing dithiocarbamate, zinc diethyldithiocarbamate, efficiently decreased the levels of pro-caspase-1 and NLRP3, whereas dithiocarbamates, dimethyldithiocarbamate and diethyldithiocarbamate without zinc, were less active.	Ditiocarb	50-77	NLR family, pyrin domain containing 3	Mus musculus	133-138
25929180-6	2015	Furthermore, the zinc-containing dithiocarbamate, zinc diethyldithiocarbamate, efficiently decreased the levels of pro-caspase-1 and NLRP3, whereas dithiocarbamates, dimethyldithiocarbamate and diethyldithiocarbamate without zinc, were less active.	Ditiocarb	55-77	NLR family, pyrin domain containing 3	Mus musculus	133-138
25929180-9	2015	These results indicate that ziram causes degradation of pro-caspase-1 and NLRP3 in a zinc- and oxidative property-dependent manner and suggest that exposure to ziram may compromise the clearance of microbial pathogens.	Ziram	28-33	NLR family, pyrin domain containing 3	Mus musculus	74-79
25690658-4	2015	We show here that P2X7R activation by ATP (EC50 = 1 mM) or benzoyl-ATP (EC50 = 300 muM) and P2X7R down-modulation caused a 2- to 8-fold up-regulation of NLRP3 mRNA in mouse N13 microglial cells.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	153-158
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	0-28	NLR family, pyrin domain containing 3	Mus musculus	73-78
25914377-2	2015	Monosodium urate monohydrate (MSU) crystals cause gout by activating the NLRP3 inflammasome, leading to interleukin-1beta (IL-1beta) production and neutrophil recruitment.	Uric Acid	30-33	NLR family, pyrin domain containing 3	Mus musculus	73-78
25626736-0	2015	Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1beta secretion and insulin resistance despite obesity.	Fatty Acids, Monounsaturated	0-26	NLR family, pyrin domain containing 3	Mus musculus	66-71
25690658-4	2015	We show here that P2X7R activation by ATP (EC50 = 1 mM) or benzoyl-ATP (EC50 = 300 muM) and P2X7R down-modulation caused a 2- to 8-fold up-regulation of NLRP3 mRNA in mouse N13 microglial cells.	benzoyl-atp	59-70	NLR family, pyrin domain containing 3	Mus musculus	153-158
25580516-9	2015	Inhibitor experiments indicated that O157:H7-induced IL-1beta production was largely dependent upon caspase-1 activation and partially dependent upon ATP signalling and cathepsin B release, which were both involved in NLRP3 activation.	Adenosine Triphosphate	150-153	NLR family, pyrin domain containing 3	Mus musculus	218-223
25582105-1	2015	BACKGROUND &amp; AIMS: It was reported that alcohol consumption activated the NLRP3 inflammasome in Kupffer cells, leading to mature interleukin (IL)-1beta release in alcoholic liver injury; however, how IL-1beta promotes liver injury remains unclear.	Adenosine Monophosphate	12-15	NLR family, pyrin domain containing 3	Mus musculus	78-83
26030099-7	2015	In addition, chCfhTg mice demonstrated upregulation of NLRP3, IP-10, CD68, and TREM-2 in the RNA isolates from RPE/MG/MPhi.	chcfhtg	13-20	NLR family, pyrin domain containing 3	Mus musculus	55-60
25582105-1	2015	BACKGROUND &amp; AIMS: It was reported that alcohol consumption activated the NLRP3 inflammasome in Kupffer cells, leading to mature interleukin (IL)-1beta release in alcoholic liver injury; however, how IL-1beta promotes liver injury remains unclear.	Alcohols	44-51	NLR family, pyrin domain containing 3	Mus musculus	78-83
25582105-6	2015	Increased gene and protein expression of mature IL-1beta correlated with elevated expression of the NLRP3 inflammasome components NLRP3, ASC, and cleaved caspase-1 in Kupffer cells from ethanol-exposed wild-type mice.	Ethanol	186-193	NLR family, pyrin domain containing 3	Mus musculus	100-105
25582105-6	2015	Increased gene and protein expression of mature IL-1beta correlated with elevated expression of the NLRP3 inflammasome components NLRP3, ASC, and cleaved caspase-1 in Kupffer cells from ethanol-exposed wild-type mice.	Ethanol	186-193	NLR family, pyrin domain containing 3	Mus musculus	130-135
25582105-8	2015	CONCLUSIONS: After alcohol-exposure Kupffer cell-derived IL-1beta triggered by NLRP3 activation, recruits and activates hepatic iNKT cells, subsequently promoting liver inflammation and neutrophil infiltration, and inducing alcoholic liver injury.	Alcohols	19-26	NLR family, pyrin domain containing 3	Mus musculus	79-84
25762778-7	2015	Third, the intracellular Ca(2+) buffer, BAPTA, and the channel blocker, 2-aminoethoxydiphenyl borate, widely used reagents for disruption of Ca(2+)-dependent signaling pathways, strongly suppressed nigericin-induced NLRP3 inflammasome signaling via mechanisms dissociated from their canonical or expected effects on Ca(2+) homeostasis.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	40-45	NLR family, pyrin domain containing 3	Mus musculus	216-221
25950489-6	2015	Conversely, in acetaminophen-mediated liver injury, blockade of either RIP1 or RIP3 was protective and was associated with lower NLRP3 inflammasome activation.	Acetaminophen	15-28	NLR family, pyrin domain containing 3	Mus musculus	129-134
25900651-7	2015	Intravaginal administration of wild-type (WT) mice with glyburide, a potent inhibitor of the NLRP3 inflammasome, reduced PMN infiltration and IL-1beta to levels comparable to those observed in Nlrp3(-/-) mice.	Glyburide	56-65	NLR family, pyrin domain containing 3	Mus musculus	93-98
25900651-7	2015	Intravaginal administration of wild-type (WT) mice with glyburide, a potent inhibitor of the NLRP3 inflammasome, reduced PMN infiltration and IL-1beta to levels comparable to those observed in Nlrp3(-/-) mice.	Glyburide	56-65	NLR family, pyrin domain containing 3	Mus musculus	193-198
25694485-8	2015	Interestingly, mRNA and protein levels of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components apoptosis-associated speck-like protein containing a caspase recruitment domain, caspase-1, and IL-1beta were dramatically increased in obstructed kidneys of 7UUO mice, which were significantly suppressed by aliskiren.	aliskiren	338-347	NLR family, pyrin domain containing 3	Mus musculus	46-97
25694485-8	2015	Interestingly, mRNA and protein levels of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components apoptosis-associated speck-like protein containing a caspase recruitment domain, caspase-1, and IL-1beta were dramatically increased in obstructed kidneys of 7UUO mice, which were significantly suppressed by aliskiren.	aliskiren	338-347	NLR family, pyrin domain containing 3	Mus musculus	99-104
25694485-10	2015	In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction.	aliskiren	61-70	NLR family, pyrin domain containing 3	Mus musculus	179-184
25581126-0	2015	NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes.	Carbon	109-115	NLR family, pyrin domain containing 3	Mus musculus	24-29
25581126-1	2015	The purpose of this paper is to elucidate the key role of NADPH oxidase in NLRP3 inflammasome activation and generation of pulmonary fibrosis by multi-walled carbon nanotubes (MWCNTs).	Carbon	158-164	NLR family, pyrin domain containing 3	Mus musculus	75-80
25581126-3	2015	In this study, three long aspect ratio (LAR) materials (MWCNTs, single-walled carbon nanotubes, and silver nanowires) are used to compare with spherical carbon black and silver nanoparticles for their ability to trigger oxygen burst activity and NLRP3 assembly.	Oxygen	220-226	NLR family, pyrin domain containing 3	Mus musculus	246-251
25739025-7	2015	In vitro, Nlrp3 inflammasome formation and its activity were instigated in cultured endothelial cells by cholesterol crystal, a danger factor associated with hypercholesterolemia.	Cholesterol	105-116	NLR family, pyrin domain containing 3	Mus musculus	10-15
25739025-8	2015	Moreover, cholesterol crystals directly induced endothelial dysfunction in coronary arteries from Nlrp3(+/+) mice, which was attenuated in Nlrp3(-/-) arteries.	Cholesterol	10-21	NLR family, pyrin domain containing 3	Mus musculus	98-103
25739025-8	2015	Moreover, cholesterol crystals directly induced endothelial dysfunction in coronary arteries from Nlrp3(+/+) mice, which was attenuated in Nlrp3(-/-) arteries.	Cholesterol	10-21	NLR family, pyrin domain containing 3	Mus musculus	139-144
25762778-7	2015	Third, the intracellular Ca(2+) buffer, BAPTA, and the channel blocker, 2-aminoethoxydiphenyl borate, widely used reagents for disruption of Ca(2+)-dependent signaling pathways, strongly suppressed nigericin-induced NLRP3 inflammasome signaling via mechanisms dissociated from their canonical or expected effects on Ca(2+) homeostasis.	2-aminoethoxydiphenyl borate	72-100	NLR family, pyrin domain containing 3	Mus musculus	216-221
25762778-7	2015	Third, the intracellular Ca(2+) buffer, BAPTA, and the channel blocker, 2-aminoethoxydiphenyl borate, widely used reagents for disruption of Ca(2+)-dependent signaling pathways, strongly suppressed nigericin-induced NLRP3 inflammasome signaling via mechanisms dissociated from their canonical or expected effects on Ca(2+) homeostasis.	Nigericin	198-207	NLR family, pyrin domain containing 3	Mus musculus	216-221
25867480-5	2015	Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals.	Adenosine Triphosphate	178-181	NLR family, pyrin domain containing 3	Mus musculus	136-141
25867480-5	2015	Emodin treatment attenuated interleukin (IL)-1beta secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals.	Silicon Dioxide	198-204	NLR family, pyrin domain containing 3	Mus musculus	136-141
25687021-9	2015	Levels of mRNA of the components of NALP-3 inflammasome, ASC, CASP-1, NALP-1 and NALP-3, also showed an age-dependent increase that was reversed by RSV.	Resveratrol	148-151	NLR family, pyrin domain containing 3	Mus musculus	36-42
25750210-7	2015	In a murine model of in utero infection, hyperpigmented GBS strains induced fetal injury in both an NLRP3 inflammasome-dependent and NLRP3 inflammasome-independent manner.	gbs	56-59	NLR family, pyrin domain containing 3	Mus musculus	100-105
25750210-7	2015	In a murine model of in utero infection, hyperpigmented GBS strains induced fetal injury in both an NLRP3 inflammasome-dependent and NLRP3 inflammasome-independent manner.	gbs	56-59	NLR family, pyrin domain containing 3	Mus musculus	133-138
25687021-9	2015	Levels of mRNA of the components of NALP-3 inflammasome, ASC, CASP-1, NALP-1 and NALP-3, also showed an age-dependent increase that was reversed by RSV.	Resveratrol	148-151	NLR family, pyrin domain containing 3	Mus musculus	81-87
25294243-9	2015	The underlying mechanisms for the COX-2-mediated increase in NLRP3 inflammasome activation were determined to be the following: (1) enhancement of lipopolysaccharide-induced proIL-1beta and NLRP3 expression by increasing NF-kappaB activation and (2) enhancement of the caspase-1 activation by increasing damaged mitochondria, mitochondrial reactive oxygen species production and release of mitochondrial DNA into cytosol.	Reactive Oxygen Species	340-363	NLR family, pyrin domain containing 3	Mus musculus	61-66
25677765-11	2015	In conclusion, our study demonstrated that wogonoside may exert its anti-inflammatory effect via dual inhibition of NF-kappaB and NLRP3 inflammasome, suggesting that wogonoside might be a potential effective drug for inflammatory bowel diseases.	wogonoside	43-53	NLR family, pyrin domain containing 3	Mus musculus	130-135
25613820-0	2015	Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.	arglabin	82-90	NLR family, pyrin domain containing 3	Mus musculus	53-58
25613820-1	2015	BACKGROUND: This study was designed to evaluate the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet.	arglabin	62-70	NLR family, pyrin domain containing 3	Mus musculus	78-83
25794175-0	2015	Protective effect of leaf essential oil from Cinnamomum osmophloeum Kanehira on endotoxin-induced intestinal injury in mice associated with suppressed local expression of molecules in the signaling pathways of TLR4 and NLRP3.	leaf essential oil	21-39	NLR family, pyrin domain containing 3	Mus musculus	219-224
25794175-7	2015	Our data provide strong evidence for a protective effect of CO of the linalool chemotype in the endotoxin-induced systemic inflammatory response in close association with suppression of the TLR4 and NLRP3 signaling pathways in intestine.	linalool	70-78	NLR family, pyrin domain containing 3	Mus musculus	199-204
25822487-7	2015	Using a variety of NLRP3 triggering mechanisms, we show that apoptotic cells negatively regulate NF-kappaB and NLRP3 activation in primary peritoneal macrophages, at pre- and post-transcription levels, via inhibition of reactive oxygen species, lysosomal stabilization, and blocking K+ efflux.	Reactive Oxygen Species	220-243	NLR family, pyrin domain containing 3	Mus musculus	19-24
25822487-7	2015	Using a variety of NLRP3 triggering mechanisms, we show that apoptotic cells negatively regulate NF-kappaB and NLRP3 activation in primary peritoneal macrophages, at pre- and post-transcription levels, via inhibition of reactive oxygen species, lysosomal stabilization, and blocking K+ efflux.	Reactive Oxygen Species	220-243	NLR family, pyrin domain containing 3	Mus musculus	111-116
25677765-0	2015	Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-kappaB and NLRP3 inflammasome activation.	wogonoside	0-10	NLR family, pyrin domain containing 3	Mus musculus	116-121
25677765-0	2015	Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-kappaB and NLRP3 inflammasome activation.	Dextran Sulfate	28-50	NLR family, pyrin domain containing 3	Mus musculus	116-121
25677765-5	2015	In this study, we investigated the anti-inflammatory effect of wogonoside in dextran sulfate sodium (DSS)-induced murine colitis and further revealed the underlying mechanisms by targeting NF-kappaB and NLRP3 inflammasome.	wogonoside	63-73	NLR family, pyrin domain containing 3	Mus musculus	203-208
25677765-11	2015	In conclusion, our study demonstrated that wogonoside may exert its anti-inflammatory effect via dual inhibition of NF-kappaB and NLRP3 inflammasome, suggesting that wogonoside might be a potential effective drug for inflammatory bowel diseases.	wogonoside	166-176	NLR family, pyrin domain containing 3	Mus musculus	130-135
25677765-9	2015	The underlying mechanisms for the protective effect of wogonoside in DSS-induced colitis may be attributed to its inhibition on NF-kappaB and NLRP3 inflammasome activation in colons.	wogonoside	55-65	NLR family, pyrin domain containing 3	Mus musculus	142-147
25677765-9	2015	The underlying mechanisms for the protective effect of wogonoside in DSS-induced colitis may be attributed to its inhibition on NF-kappaB and NLRP3 inflammasome activation in colons.	Dextran Sulfate	69-72	NLR family, pyrin domain containing 3	Mus musculus	142-147
25686106-10	2015	In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1beta secretion in mouse models of NLRP3-mediated diseases such as Muckle-Wells syndrome, familial cold autoinflammatory syndrome and urate crystal-induced peritonitis.	3-Hydroxybutyric Acid	9-12	NLR family, pyrin domain containing 3	Mus musculus	107-112
25681332-0	2015	The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.	cyclopentenone	4-18	NLR family, pyrin domain containing 3	Mus musculus	65-70
25681332-0	2015	The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes.	prostaglandin 15d-pgj2	19-41	NLR family, pyrin domain containing 3	Mus musculus	65-70
25681332-3	2015	We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes.	Eicosanoids	19-29	NLR family, pyrin domain containing 3	Mus musculus	186-191
25681332-3	2015	We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes.	15-deoxy-delta(12,14)-prostaglandin J2	30-56	NLR family, pyrin domain containing 3	Mus musculus	186-191
25681332-3	2015	We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes.	15-deoxy-delta(12,14)-prostaglandin J2	58-66	NLR family, pyrin domain containing 3	Mus musculus	186-191
25681332-3	2015	We report that the eicosanoid 15-deoxy-Delta(12,14)-PGJ2 (15d-PGJ2) and related cyclopentenone PGs inhibit caspase-1 activation by the NLR family leucine-rich repeat protein (NLRP)1 and NLRP3 inflammasomes.	cyclopentenone	80-94	NLR family, pyrin domain containing 3	Mus musculus	186-191
25681332-8	2015	In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release.	Uric Acid	44-60	NLR family, pyrin domain containing 3	Mus musculus	82-87
25681332-8	2015	In a mouse peritonitis model of gout, using monosodium urate crystals to activate NLRP3, 15d-PGJ2 caused a significant inhibition of cell recruitment and associated IL-1beta release.	15-deoxy-delta(12,14)-prostaglandin J2	89-97	NLR family, pyrin domain containing 3	Mus musculus	82-87
25596528-3	2015	In mice, DNA damage initiated by chemotherapeutic drug cyclophosphamide activated caspase 1 through the formation of the NLRP3 complex resulting in detrusor hyperplasia.	Cyclophosphamide	55-71	NLR family, pyrin domain containing 3	Mus musculus	121-126
25543031-0	2015	Oxygen-glucose deprivation inducing B1 RNA inhibits neuronal cells metabolic activity by NLRP3 and associated proinflammatory cytokines production.	oxygen-glucose	0-14	NLR family, pyrin domain containing 3	Mus musculus	89-94
25548278-2	2015	Recent investigations suggest the possible role of NLRP3 inflammasomes, which regulate IL-1beta production and lead to inflammatory responses, in the pathophysiology of HALI; however, their role is not fully understood.	hali	169-173	NLR family, pyrin domain containing 3	Mus musculus	51-56
25548278-3	2015	In this study, we investigated the role of NLRP3 inflammasomes in mice with HALI.	hali	76-80	NLR family, pyrin domain containing 3	Mus musculus	43-48
25548278-9	2015	These findings demonstrate that NLRP3 regulates Stat3 signaling in alveolar epithelial cells by affecting macrophage and neutrophil function independent of IL-1beta production and contributes to the pathophysiology of HALI.	hali	218-222	NLR family, pyrin domain containing 3	Mus musculus	32-37
25582856-6	2015	In vivo, in a monosodium urate crystal (MSU)-induced NLRP3-dependent peritonitis model, MSU-induced IL-1beta production and neutrophil flux were significantly reduced in beta-arrestin1 knockout mice.	monosodium urate crystal	14-38	NLR family, pyrin domain containing 3	Mus musculus	53-58
25582856-6	2015	In vivo, in a monosodium urate crystal (MSU)-induced NLRP3-dependent peritonitis model, MSU-induced IL-1beta production and neutrophil flux were significantly reduced in beta-arrestin1 knockout mice.	msu	40-43	NLR family, pyrin domain containing 3	Mus musculus	53-58
25523461-0	2015	Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.	asiatic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	122-127
25524927-5	2015	METHODS AND RESULTS: We used mice with mutant NLRP3 (constitutively active), NLRP3-A350V, under the control of tamoxifen-driven expression of the Cre recombinase (Nlrp3-A350V/CreT mice).	Tamoxifen	111-120	NLR family, pyrin domain containing 3	Mus musculus	163-168
25524927-7	2015	Tamoxifen treatment induced the inflammasome in the spleen but not in the heart, despite expression of the mutant NLRP3-A350V.	Tamoxifen	0-9	NLR family, pyrin domain containing 3	Mus musculus	114-119
25523461-8	2015	Taken together, our results demonstrate the ability of asiatic acid to inhibit NLRP3 inflammasome activation and its potential usage in the treatment of inflammatory bowel diseases.	asiatic acid	55-67	NLR family, pyrin domain containing 3	Mus musculus	79-84
25523461-0	2015	Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.	Dextran Sulfate	25-47	NLR family, pyrin domain containing 3	Mus musculus	122-127
25523461-5	2015	At the same time, decreased activation of caspase-1 in peritoneal macrophages was detected in asiatic acid-treated mice, which suggested that the NLRP3 inflammasome activation was suppressed.	asiatic acid	94-106	NLR family, pyrin domain containing 3	Mus musculus	146-151
25603858-8	2015	Pretreatment with the NLRP3 inflammasome inhibitor VX-765 decreased serum and hippocampal levels of interleukin-1beta protein and significantly moderated the depressive-like behaviors induced by chronic mild stress.	belnacasan	51-57	NLR family, pyrin domain containing 3	Mus musculus	22-27
25351950-2	2015	Cell culture, RNA transfection, adenosine triphosphate (ATP)-induced expression of NALP3, reverse transcription polymerase chain reaction and western blotting were used to explore the association between the P2X7 receptor and NALP3-encoding gene in P388D1 murine macrophage-like cells at the molecular level.	Adenosine Triphosphate	32-54	NLR family, pyrin domain containing 3	Mus musculus	83-88
25351950-2	2015	Cell culture, RNA transfection, adenosine triphosphate (ATP)-induced expression of NALP3, reverse transcription polymerase chain reaction and western blotting were used to explore the association between the P2X7 receptor and NALP3-encoding gene in P388D1 murine macrophage-like cells at the molecular level.	Adenosine Triphosphate	56-59	NLR family, pyrin domain containing 3	Mus musculus	83-88
25574840-9	2015	FASN inhibition by shRNA and treatment with the chemical inhibitors C75 and cerulenin suppressed NLRP3-mediated caspase-1 activation and inhibited NLRP3 and pro-IL-1beta gene expression in macrophages.	Cerulenin	76-85	NLR family, pyrin domain containing 3	Mus musculus	97-102
25574840-9	2015	FASN inhibition by shRNA and treatment with the chemical inhibitors C75 and cerulenin suppressed NLRP3-mediated caspase-1 activation and inhibited NLRP3 and pro-IL-1beta gene expression in macrophages.	Cerulenin	76-85	NLR family, pyrin domain containing 3	Mus musculus	147-152
25520429-5	2015	KCs that formed CLSs stained positive for NLRP3, implicating activation of the NLRP3 inflammasome in response to cholesterol crystals.	Cholesterol	113-124	NLR family, pyrin domain containing 3	Mus musculus	42-47
25520429-5	2015	KCs that formed CLSs stained positive for NLRP3, implicating activation of the NLRP3 inflammasome in response to cholesterol crystals.	Cholesterol	113-124	NLR family, pyrin domain containing 3	Mus musculus	79-84
25520429-8	2015	These findings are consistent with a causative link between exposure of hepatocytes and KCs to cholesterol crystals and with the development of NASH possibly mediated by NLRP3 activation.	Cholesterol	95-106	NLR family, pyrin domain containing 3	Mus musculus	170-175
25378412-7	2015	Furthermore, angiotensin II stimulated generation of mitochondria-derived reactive oxygen species in the adventitial macrophages, and this mitochondria-derived reactive oxygen species generation was inhibited by NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain, and caspase-1 deficiency.	Reactive Oxygen Species	160-183	NLR family, pyrin domain containing 3	Mus musculus	212-217
25499818-3	2015	More importantly, nuciferine suppressed renal activation of Toll-like receptor 4/myeloid differentiation factor 88/NF-kappaB (TLR4/MyD88/NF-kappaB) signaling and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome to reduce serum and renal IL-1beta levels in hyperuricemic mice with renal inflammation reduction.	nuciferine	18-28	NLR family, pyrin domain containing 3	Mus musculus	215-220
25378412-8	2015	In vitro experiments revealed that angiotensin II stimulated the NLRP3 inflammasome activation and subsequent interleukin-1beta release in macrophages, and this activation was mediated through an angiotensin type I receptor/mitochondria-derived reactive oxygen species-dependent pathway.	Reactive Oxygen Species	245-268	NLR family, pyrin domain containing 3	Mus musculus	65-70
26777707-10	2015	Hemin also promoted the binding of NMDAR1 to NLRP3.	Hemin	0-5	NLR family, pyrin domain containing 3	Mus musculus	45-50
25967960-9	2015	In addition, resveratrol, with or without sodium alginate, could reduce NLRP3 expression obviously in the synovial tissues.	Resveratrol	13-24	NLR family, pyrin domain containing 3	Mus musculus	72-77
25967960-9	2015	In addition, resveratrol, with or without sodium alginate, could reduce NLRP3 expression obviously in the synovial tissues.	Alginates	42-57	NLR family, pyrin domain containing 3	Mus musculus	72-77
25211550-3	2015	Furthermore, NS-induced pregnancy complications were markedly improved in Nlrp3(-/-) mice but not in component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-deficient (Asc(-/-)) mice, indicating the independence of NLRP3 inflammasomes.	ns	13-15	NLR family, pyrin domain containing 3	Mus musculus	74-79
26777707-9	2015	Hemin up regulated NLRP3 and IL-1b level, which was reversed by MK801 (NMDAR antagonist) in vitro.	Dizocilpine Maleate	64-69	NLR family, pyrin domain containing 3	Mus musculus	19-24
25075770-8	2015	Mitochondrial reactive oxygen species (ROS) activate the Nlrp3 inflammasome in glucose or advanced glycation end product stressed podocytes.	Reactive Oxygen Species	14-37	NLR family, pyrin domain containing 3	Mus musculus	57-62
25075770-8	2015	Mitochondrial reactive oxygen species (ROS) activate the Nlrp3 inflammasome in glucose or advanced glycation end product stressed podocytes.	Reactive Oxygen Species	39-42	NLR family, pyrin domain containing 3	Mus musculus	57-62
25075770-8	2015	Mitochondrial reactive oxygen species (ROS) activate the Nlrp3 inflammasome in glucose or advanced glycation end product stressed podocytes.	Glucose	79-86	NLR family, pyrin domain containing 3	Mus musculus	57-62
25211550-3	2015	Furthermore, NS-induced pregnancy complications were markedly improved in Nlrp3(-/-) mice but not in component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-deficient (Asc(-/-)) mice, indicating the independence of NLRP3 inflammasomes.	ns	13-15	NLR family, pyrin domain containing 3	Mus musculus	255-260
25404286-6	2014	LT-induced NLRP1b inflammasome activation was shown to be impaired upon inhibition of potassium efflux, which is known to play a major role in NLRP3 inflammasome formation and ASC dimerization.	Potassium	86-95	NLR family, pyrin domain containing 3	Mus musculus	143-148
25405767-6	2014	Exposure of islets lacking functional NLRP3 or caspase-1 to H2O2, rotenone or thapsigargin induced similar cell death as in wild-type islets.	Rotenone	66-74	NLR family, pyrin domain containing 3	Mus musculus	38-43
25405767-6	2014	Exposure of islets lacking functional NLRP3 or caspase-1 to H2O2, rotenone or thapsigargin induced similar cell death as in wild-type islets.	Thapsigargin	78-90	NLR family, pyrin domain containing 3	Mus musculus	38-43
25405767-3	2014	ER stress, oxidative stress and high glucose concentrations may also activate the NLRP3 inflammasome leading to interleukin (IL)-1beta production and caspase-1 dependent pyroptosis.	Glucose	37-44	NLR family, pyrin domain containing 3	Mus musculus	82-87
25405767-6	2014	Exposure of islets lacking functional NLRP3 or caspase-1 to H2O2, rotenone or thapsigargin induced similar cell death as in wild-type islets.	Hydrogen Peroxide	60-64	NLR family, pyrin domain containing 3	Mus musculus	38-43
25405768-8	2014	RESULTS: The inflammasome-associated proteins NALP3 and ASC, but not IPAF and AIM2, are required for CS-induced IL-1beta/IL-18 release, but not IL-1alpha.	Cesium	101-103	NLR family, pyrin domain containing 3	Mus musculus	46-51
25405768-12	2014	CONCLUSION: This data indicates a key role for the P2X7-NALP3/ASC-caspase1/11-IL-1beta/IL-18 axis in CS induced airway inflammation, highlighting this pathway as a possible therapeutic target for the treatment of COPD.	Cesium	101-103	NLR family, pyrin domain containing 3	Mus musculus	56-61
24861026-3	2014	Gain of function tamoxifen-inducible Nlrp3 knock-in mice allowing for in vivo temporal control of NLRP3 activation and loss of function Nlrp3 knockout mice were placed on short-term choline-deficient amino acid-defined (CDAA) diet, to induce isolated hepatic steatosis or long-term CDAA exposure, to induce severe steatohepatitis and fibrosis, respectively.	Tamoxifen	17-26	NLR family, pyrin domain containing 3	Mus musculus	37-42
25308879-4	2014	Moreover, we measured the changes of nod-like receptor family, pyrin domain containing proteins (NLRP3) inflammasome components, oxidative stress, and proapoptotic genes in renal tissues in cisplatin-induced nephrotoxicity after treatment with A-438079.	Cisplatin	190-199	NLR family, pyrin domain containing 3	Mus musculus	97-102
25308879-7	2014	These effects were associated with the significantly reduced levels of NLRP3 inflammasome components, oxidative stress, p53 and caspase-3 in renal tissues in cisplatin-induced nephrotoxicity.	Cisplatin	158-167	NLR family, pyrin domain containing 3	Mus musculus	71-76
24917577-0	2014	Fluvastatin causes NLRP3 inflammasome-mediated adipose insulin resistance.	Fluvastatin	0-11	NLR family, pyrin domain containing 3	Mus musculus	19-24
24917577-7	2014	Fluvastatin-induced activation of the NLRP3/caspase-1 pathway was required for the development of insulin resistance in adipose tissue explants, an effect also prevented by glyburide.	Fluvastatin	0-11	NLR family, pyrin domain containing 3	Mus musculus	38-43
24917577-7	2014	Fluvastatin-induced activation of the NLRP3/caspase-1 pathway was required for the development of insulin resistance in adipose tissue explants, an effect also prevented by glyburide.	Glyburide	173-182	NLR family, pyrin domain containing 3	Mus musculus	38-43
25295542-4	2014	Here, we determined that macrophage-generated CO promotes ATP production and release by bacteria, which then activates the Nacht, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome, intensifying bacterial killing.	Adenosine Triphosphate	58-61	NLR family, pyrin domain containing 3	Mus musculus	123-171
25295542-4	2014	Here, we determined that macrophage-generated CO promotes ATP production and release by bacteria, which then activates the Nacht, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome, intensifying bacterial killing.	Adenosine Triphosphate	58-61	NLR family, pyrin domain containing 3	Mus musculus	173-178
25295542-10	2014	The ATP then bound to macrophage nucleotide P2 receptors, resulting in activation of the NALP3/IL-1beta inflammasome to amplify bacterial phagocytosis by macrophages.	Adenosine Triphosphate	4-7	NLR family, pyrin domain containing 3	Mus musculus	89-94
25448682-0	2014	Suppression of NF-kappaB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone.	fraxinellone	175-187	NLR family, pyrin domain containing 3	Mus musculus	39-44
25356867-0	2014	NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation.	Reactive Oxygen Species	47-50	NLR family, pyrin domain containing 3	Mus musculus	0-5
25356867-2	2014	In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed mitochondrial ROS inhibitor, NecroX-5.	Reactive Oxygen Species	66-89	NLR family, pyrin domain containing 3	Mus musculus	100-105
25356867-2	2014	In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed mitochondrial ROS inhibitor, NecroX-5.	Reactive Oxygen Species	91-94	NLR family, pyrin domain containing 3	Mus musculus	100-105
25356867-2	2014	In this study, to evaluate the relationship between mitochondrial reactive oxygen species (ROS) and NLRP3 inflammasome activation in allergic asthma, we used a newly developed mitochondrial ROS inhibitor, NecroX-5.	NecroX-5	205-213	NLR family, pyrin domain containing 3	Mus musculus	100-105
25356867-5	2014	These findings suggest that mitochondrial ROS have a critical role in the pathogenesis of allergic airway inflammation through the modulation of NLRP3 inflammasome activation, providing a novel role of airway epithelial cells expressing NLRP3 inflammasome as an immune responder.	Reactive Oxygen Species	42-45	NLR family, pyrin domain containing 3	Mus musculus	145-150
25356867-5	2014	These findings suggest that mitochondrial ROS have a critical role in the pathogenesis of allergic airway inflammation through the modulation of NLRP3 inflammasome activation, providing a novel role of airway epithelial cells expressing NLRP3 inflammasome as an immune responder.	Reactive Oxygen Species	42-45	NLR family, pyrin domain containing 3	Mus musculus	237-242
24861026-5	2014	Nlrp3(-/-) mice were protected from long-term feeding CDAA-induced hepatomegaly, liver injury, and infiltration of activated macrophages.	CDAA	54-58	NLR family, pyrin domain containing 3	Mus musculus	0-5
24861026-6	2014	More importantly, Nlrp3(-/-) mice showed marked protection from CDAA-induced liver fibrosis.	CDAA	64-68	NLR family, pyrin domain containing 3	Mus musculus	18-23
25152324-5	2014	We hypothesized that inhibition of the NLRP3 inflammasome with the sulfonylurea drug glyburide would reduce disease severity in obese mice with cerulein-induced SAP.	Glyburide	85-94	NLR family, pyrin domain containing 3	Mus musculus	39-44
24691785-6	2014	Furthermore, well established inflammasome triggers (ATP, nigericin, and crystals) in humans and mice had similar effects on porcine NLRP3 inflammasome activation.	Adenosine Triphosphate	53-56	NLR family, pyrin domain containing 3	Mus musculus	133-138
25216263-6	2014	In addition, the genetic (small interfering ribonucleic acid [siRNA]) and pharmacological (glyburide) inhibition of the NLRP3 inflammasome in CFs can block this signaling pathway.	Glyburide	91-100	NLR family, pyrin domain containing 3	Mus musculus	120-125
25216263-7	2014	Furthermore, the inhibition of the NLRP3 inflammasome in cardiac fibroblasts ameliorated the ability of LPS-challenged CFs to impact cardiomyocyte function as assessed by intracellular cyclic adenosine monophosphate (cAMP) responses in cardiomyocytes.	Cyclic AMP	185-215	NLR family, pyrin domain containing 3	Mus musculus	35-40
25216263-7	2014	Furthermore, the inhibition of the NLRP3 inflammasome in cardiac fibroblasts ameliorated the ability of LPS-challenged CFs to impact cardiomyocyte function as assessed by intracellular cyclic adenosine monophosphate (cAMP) responses in cardiomyocytes.	Cyclic AMP	217-221	NLR family, pyrin domain containing 3	Mus musculus	35-40
25138219-1	2014	NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate NLRP3 inflammasomes resulting in podocyte and glomerular injury during hyperhomocysteinemia (hHcys).	Reactive Oxygen Species	22-45	NLR family, pyrin domain containing 3	Mus musculus	83-88
25138219-1	2014	NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate NLRP3 inflammasomes resulting in podocyte and glomerular injury during hyperhomocysteinemia (hHcys).	Reactive Oxygen Species	47-50	NLR family, pyrin domain containing 3	Mus musculus	83-88
25138219-4	2014	In cultured podocytes, size exclusion chromatography and confocal microscopy showed that inhibition of TXNIP by siRNA or verapamil prevented Hcys-induced TXNIP protein recruitment to form NLRP3 inflammasomes and abolished Hcys-induced increases in caspase-1 activity and IL-1beta production.	Verapamil	121-130	NLR family, pyrin domain containing 3	Mus musculus	188-193
25138219-4	2014	In cultured podocytes, size exclusion chromatography and confocal microscopy showed that inhibition of TXNIP by siRNA or verapamil prevented Hcys-induced TXNIP protein recruitment to form NLRP3 inflammasomes and abolished Hcys-induced increases in caspase-1 activity and IL-1beta production.	Homocysteine	141-145	NLR family, pyrin domain containing 3	Mus musculus	188-193
25138219-7	2014	Evidenced by immunofluorescence and co-immunoprecipitation studies, glomerular inflammasome formation and TXNIP binding to NLRP3 were markedly increased in mice with hHcys but not in TXNIP shRNA-transfected mice or those receiving verapamil.	Verapamil	231-240	NLR family, pyrin domain containing 3	Mus musculus	123-128
25254654-0	2014	Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection.	Reactive Oxygen Species	0-23	NLR family, pyrin domain containing 3	Mus musculus	91-96
25254654-5	2014	Increased ROS in Rip2-deficient macrophages subsequently enhances c-Jun N-terminal kinase (JNK) signaling resulting in increased caspase-11 expression and activation, and more non-canonical NLRP3-dependant inflammasome activation.	Reactive Oxygen Species	10-13	NLR family, pyrin domain containing 3	Mus musculus	190-195
24621884-7	2014	Furthermore, Ipt negatively regulated nod-like receptor protein 3 (NLRP3) expression and, in turn, inhibited microglia-mediated neuro-inflammation by suppressing the activation of NLRP3-inflammasome/caspase-1/interleukin 1beta axis in the hippocampus of CMS mice.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	13-16	NLR family, pyrin domain containing 3	Mus musculus	38-65
24621884-7	2014	Furthermore, Ipt negatively regulated nod-like receptor protein 3 (NLRP3) expression and, in turn, inhibited microglia-mediated neuro-inflammation by suppressing the activation of NLRP3-inflammasome/caspase-1/interleukin 1beta axis in the hippocampus of CMS mice.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	13-16	NLR family, pyrin domain containing 3	Mus musculus	67-72
24621884-7	2014	Furthermore, Ipt negatively regulated nod-like receptor protein 3 (NLRP3) expression and, in turn, inhibited microglia-mediated neuro-inflammation by suppressing the activation of NLRP3-inflammasome/caspase-1/interleukin 1beta axis in the hippocampus of CMS mice.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	13-16	NLR family, pyrin domain containing 3	Mus musculus	180-185
25272939-0	2014	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.	Losartan	0-8	NLR family, pyrin domain containing 3	Mus musculus	101-106
25272939-0	2014	Losartan inhibits LPS + ATP-induced IL-1beta secretion from mouse primary macrophages by suppressing NALP3 inflammasome.	Adenosine Triphosphate	24-27	NLR family, pyrin domain containing 3	Mus musculus	101-106
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Losartan	86-94	NLR family, pyrin domain containing 3	Mus musculus	141-146
25272939-4	2014	To further elucidate the molecular mechanism underlying the anti-IL-1beta property of losartan, we studied the LPS+ATP-induced activation of NALP3 inflammasome which controls the muturation and secretion of IL-1beta.	Adenosine Triphosphate	115-118	NLR family, pyrin domain containing 3	Mus musculus	141-146
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Thioglycolates	21-35	NLR family, pyrin domain containing 3	Mus musculus	178-183
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Thioglycolates	21-35	NLR family, pyrin domain containing 3	Mus musculus	228-233
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Adenosine Triphosphate	81-84	NLR family, pyrin domain containing 3	Mus musculus	178-183
25272939-7	2014	RESULTS: In cultured thioglycollate-elicited macrophages, we observed that LPS + ATP greatly enhanced IL-1 beta secretion (6938.00 +/- 83.45; P &lt; 0.05) and the mRNA levels of NALP3, caspase-1 which are two main components of NALP3 inflammasome (60.88 +/- 8.28; 1.31 +/- 0.04, P &lt; 0.05 for both).	Adenosine Triphosphate	81-84	NLR family, pyrin domain containing 3	Mus musculus	228-233
25272939-8	2014	The macrophages co-cultured with losartan showed low production of IL-1beta (3907.50 +/- 143.61; P &lt; 0.05) and low production of NALP3, caspase-1mRNA (29.82 +/- 6.92; 1.12 +/- 0.05, P &lt; 0.05 for both).	Losartan	33-41	NLR family, pyrin domain containing 3	Mus musculus	132-137
25272939-10	2014	CONCLUSIONS: Our results show that the NALP3 inflammasome is up-regulated and activated in the mouse macrophage in response to LPS + ATP stimulation.	Adenosine Triphosphate	133-136	NLR family, pyrin domain containing 3	Mus musculus	39-44
24841199-0	2014	Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.	Reactive Oxygen Species	36-59	NLR family, pyrin domain containing 3	Mus musculus	14-19
24836981-0	2014	Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye.	Reactive Oxygen Species	0-23	NLR family, pyrin domain containing 3	Mus musculus	34-39
24836981-3	2014	There is emerging evidence in other tissues that innate immune responses to a variety of environmental stresses stem from ROS-induced cytosolic NLRP3 inflammasome activation.	Reactive Oxygen Species	122-125	NLR family, pyrin domain containing 3	Mus musculus	144-149
24836981-5	2014	We determined the role of ROS generation in mediating increases in IL-1beta secretion through caspase-1 activation caused by NLRP3 inflammasome activation in an environment-induced murine dry eye (DE) model.	Reactive Oxygen Species	26-29	NLR family, pyrin domain containing 3	Mus musculus	125-130
24836981-7	2014	Increases in ROS production preceded rises in corneal and conjunctival gene expression of NLRP3 inflammasome components and IL-1beta that were identified using real-time PCR.	Reactive Oxygen Species	13-16	NLR family, pyrin domain containing 3	Mus musculus	90-95
24836981-10	2014	Rises in ROS generation occurred after 1 week of ICES exposure, which preceded increases in gene expression of three NLRP3 inflammasome components (i.e. NLRP3, ASC and caspase-1) leading to rises in bioactive IL-1beta release.	Reactive Oxygen Species	9-12	NLR family, pyrin domain containing 3	Mus musculus	117-122
24836981-10	2014	Rises in ROS generation occurred after 1 week of ICES exposure, which preceded increases in gene expression of three NLRP3 inflammasome components (i.e. NLRP3, ASC and caspase-1) leading to rises in bioactive IL-1beta release.	Reactive Oxygen Species	9-12	NLR family, pyrin domain containing 3	Mus musculus	153-158
24836981-14	2014	NAC also down-regulated both increases in NLRP3, ASC, caspase-1 and IL-1beta mRNA levels, along with their immunostaining.	Acetylcysteine	0-3	NLR family, pyrin domain containing 3	Mus musculus	42-47
24836981-16	2014	We show in a dessicating DE disease murine model that rises in ROS generation trigger NLRP3 inflammasome complexation and activation leading to increases in bioactive IL-1beta secretion.	Reactive Oxygen Species	63-66	NLR family, pyrin domain containing 3	Mus musculus	86-91
25136295-0	2014	Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells.	Reactive Oxygen Species	21-24	NLR family, pyrin domain containing 3	Mus musculus	55-60
25136295-0	2014	Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells.	Ethanol	39-46	NLR family, pyrin domain containing 3	Mus musculus	55-60
25136295-6	2014	Ethanol, as ATP and LPS treatments, up-regulates NLRP3 expression, and causes caspase-1 cleavage and the release of IL-1beta and IL-18 in astrocytes supernatant.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	49-54
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Ethanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	203-208
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Reactive Oxygen Species	76-99	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Reactive Oxygen Species	101-104	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Reactive Oxygen Species	101-104	NLR family, pyrin domain containing 3	Mus musculus	203-208
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Reactive Oxygen Species	160-163	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	272-282	NLR family, pyrin domain containing 3	Mus musculus	16-21
25077824-19	2014	Furthermore, Nalp3 and Caspase-1 levels were markedly increased by high glucose plus LPS, and both proteins were significantly inhibited by glibenclamide treatment.	Glyburide	140-153	NLR family, pyrin domain containing 3	Mus musculus	13-18
25077824-20	2014	CONCLUSIONS: We conclude that glibenclamide could attenuate myocardial injury induced by LPS challenge in STZ-mice, which was possibly related to inhibiting inflammation through Nalp3 inflammasomes.	Glyburide	30-43	NLR family, pyrin domain containing 3	Mus musculus	178-183
24836981-17	2014	These results prompt us to suggest that the ROS-NLRP3-IL-1beta signaling pathway might play a priming role in environment-induced DE progression.	Reactive Oxygen Species	44-47	NLR family, pyrin domain containing 3	Mus musculus	48-53
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Ethanol	379-386	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-7	2014	Ethanol-induced NLRP3/caspase-1 activation is mediated by mitochondrial (m) reactive oxygen species (ROS) generation because when using a specific mitochondria ROS scavenger, the mito-TEMPO (500 muM) or NLRP3 blocking peptide (4 mug/ml) or a specific caspase-1 inhibitor, Z-YVAD-FMK (10 muM), abrogates mROS release and reduces the up-regulation of IL-1beta and IL-18 induced by ethanol or LPS or ATP.	Adenosine Triphosphate	397-400	NLR family, pyrin domain containing 3	Mus musculus	16-21
25136295-8	2014	Confocal microscopy studies further confirm that ethanol, ATP or LPS promotes NLRP3/caspase-1 complex recruitment within the mitochondria to promote cell death by caspase-1-mediated pyroptosis, which accounts for  73% of total cell death ( 22%) and the remaining ( 25%) die by caspase-3-dependent apoptosis.	Ethanol	49-56	NLR family, pyrin domain containing 3	Mus musculus	78-83
25136295-8	2014	Confocal microscopy studies further confirm that ethanol, ATP or LPS promotes NLRP3/caspase-1 complex recruitment within the mitochondria to promote cell death by caspase-1-mediated pyroptosis, which accounts for  73% of total cell death ( 22%) and the remaining ( 25%) die by caspase-3-dependent apoptosis.	Adenosine Triphosphate	58-61	NLR family, pyrin domain containing 3	Mus musculus	78-83
25136295-9	2014	Suppression of the TLR4 function abrogates most ethanol effects on NLRP3 activation and reduces cell death.	Ethanol	48-55	NLR family, pyrin domain containing 3	Mus musculus	67-72
25136295-10	2014	These findings suggest that NLRP3 participates, in ethanol-induced neuroinflammation and highlight the NLRP3/TLR4 crosstalk in ethanol-induced brain injury.	Ethanol	51-58	NLR family, pyrin domain containing 3	Mus musculus	28-33
25136295-10	2014	These findings suggest that NLRP3 participates, in ethanol-induced neuroinflammation and highlight the NLRP3/TLR4 crosstalk in ethanol-induced brain injury.	Ethanol	127-134	NLR family, pyrin domain containing 3	Mus musculus	103-108
24841199-7	2014	Instead, mitochondrially localized NLRP3 potentiated reactive oxygen species to augment R-Smad activation.	Reactive Oxygen Species	53-76	NLR family, pyrin domain containing 3	Mus musculus	35-40
24829412-6	2014	Three mechanisms for NLRP3 inflammasome activation may contribute: K(+) efflux, reactive oxygen species, and lysosomal destabilization.	Reactive Oxygen Species	80-103	NLR family, pyrin domain containing 3	Mus musculus	21-26
24464629-0	2014	Heme induces IL-1beta secretion through activating NLRP3 in kidney inflammation.	Heme	0-4	NLR family, pyrin domain containing 3	Mus musculus	51-56
24464629-5	2014	Here, we find that heme induces IL-1beta secretion through activating NLRP3 inflammasome in macrophages.	Heme	19-23	NLR family, pyrin domain containing 3	Mus musculus	70-75
24464629-6	2014	Heme activates NLRP3 through P2X receptors, especially the P2X7R and P2X4R.	Heme	0-4	NLR family, pyrin domain containing 3	Mus musculus	15-20
24464629-8	2014	Our study proves that heme is a potential danger activator of NLRP3 inflammasome that plays an essential role in IL-1beta secretion during kidney inflammation and provides new insight into the mechanism of innate immune initiation.	Heme	22-26	NLR family, pyrin domain containing 3	Mus musculus	62-67
24789624-0	2014	Lipopolysaccharide/adenosine triphosphate induces IL-1beta and IL-18 secretion through the NLRP3 inflammasome in RAW264.7 murine macrophage cells.	Adenosine Triphosphate	19-41	NLR family, pyrin domain containing 3	Mus musculus	91-96
24687687-5	2014	The NLRP3 inflammasome in APCs was critical to potentiate NKT-cell-mediated immune responses, since C57BL/6 NLRP3 inflammasome-deficient mice exhibited reduced responsiveness to alpha-galactosylceramide.	alpha-galactosylceramide	178-202	NLR family, pyrin domain containing 3	Mus musculus	4-9
24687687-5	2014	The NLRP3 inflammasome in APCs was critical to potentiate NKT-cell-mediated immune responses, since C57BL/6 NLRP3 inflammasome-deficient mice exhibited reduced responsiveness to alpha-galactosylceramide.	alpha-galactosylceramide	178-202	NLR family, pyrin domain containing 3	Mus musculus	108-113
24687687-6	2014	Importantly, NKT cells were found to act as regulators of NLRP3 inflammasome signaling, as NKT-cell-derived TNF-alpha was required for optimal IL-1beta and IL-18 production by myeloid cells in response to alpha-galactosylceramide, by acting on the NLRP3 inflammasome priming step.	alpha-galactosylceramide	205-229	NLR family, pyrin domain containing 3	Mus musculus	58-63
26344742-3	2014	We have recently reported that intramuscular injection of PCEP induces NLRP3, an inflammasome receptor gene, and inflammatory cytokines, including IL-1beta and IL-18, in mouse muscle tissue.	poly(bis(carboxylatoethylphenoxy)phosphazene)	58-62	NLR family, pyrin domain containing 3	Mus musculus	71-76
24619705-0	2014	Polyhydroxylated metallofullerenols stimulate IL-1beta secretion of macrophage through TLRs/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation.	metallofullerenols	17-35	NLR family, pyrin domain containing 3	Mus musculus	120-125
24619705-5	2014	Small interfering RNA (siRNA) knockdown shows that NLRP3 inflammasomes, but not NLRC4, participate in fullerenol-induced IL-1beta production.	fullerenol	102-112	NLR family, pyrin domain containing 3	Mus musculus	51-56
24619705-9	2014	Our work demonstrated that fullerenols can greatly activate macrophage and promote IL-1beta production via both TLRs/MyD88/NF-kappaB pathway and NLRP3 inflammasome activation, while Gd@C82(OH)22 had stronger ability C60(OH)22 due to the different electron affinity on the surface of carbon cage induced by the encaged gadolinium ion.	fullerenol	27-38	NLR family, pyrin domain containing 3	Mus musculus	145-150
24629563-0	2014	Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation.	Resveratrol	0-11	NLR family, pyrin domain containing 3	Mus musculus	60-65
24798340-7	2014	Biochemical analysis revealed that Nrf2 appeared in the ASC-enriched cytosolic compartment after NLRP3 inflammasome activation.	asc	56-59	NLR family, pyrin domain containing 3	Mus musculus	97-102
24798340-8	2014	Furthermore, mitochondrial reactive oxygen species-induced NLRP3 activation also required Nrf2.	Reactive Oxygen Species	27-50	NLR family, pyrin domain containing 3	Mus musculus	59-64
24911523-3	2014	Exposure to DHA reduced IL-1beta production by ligands that stimulate the NLRP3, AIM2, and NAIP5/NLRC4 inflammasomes.	Docosahexaenoic Acids	12-15	NLR family, pyrin domain containing 3	Mus musculus	74-79
24879148-4	2014	Here we show that the small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through inhibiting the NLRP3 inflammasome.	andrographolide	37-52	NLR family, pyrin domain containing 3	Mus musculus	171-176
24879148-4	2014	Here we show that the small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through inhibiting the NLRP3 inflammasome.	andrographolide	54-59	NLR family, pyrin domain containing 3	Mus musculus	171-176
24657625-11	2014	RESULTS: In macrophages and monocytes, increasing concentrations of lactate reduced TLR4-mediated induction of Il1B, Nlrp3, and Casp1; activation of NF-kappaB; release of IL1beta; and cleavage of CASP1.	Lactic Acid	68-75	NLR family, pyrin domain containing 3	Mus musculus	117-122
24657625-15	2014	CONCLUSIONS: Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81.	Lactic Acid	13-20	NLR family, pyrin domain containing 3	Mus musculus	63-68
24470197-8	2014	FSTL-1 activated the mitochondrial electron transport chain, increased the production of ATP (a key activator of the nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome) and IL-1beta secretion.	Adenosine Triphosphate	89-92	NLR family, pyrin domain containing 3	Mus musculus	170-175
24583148-3	2014	This study investigated the effect of hemin (a potent HO-1 inducer) on NLRP3 inflammasome in sepsis-induced ALI.	Hemin	38-43	NLR family, pyrin domain containing 3	Mus musculus	71-76
24583148-8	2014	In lung tissues, hemin down-regulated mRNA and protein levels of NLRP3, ASC and caspase-1.	Hemin	17-22	NLR family, pyrin domain containing 3	Mus musculus	65-70
24583148-12	2014	Our study suggests that hemin-inhibited NLRP3 inflammasome activation involved HO-1, reducing IL-1beta and IL-18 secretion and limiting the inflammatory response.	Hemin	24-29	NLR family, pyrin domain containing 3	Mus musculus	40-45
24696236-6	2014	NLRP3(-/-) mice showed reduced inflammatory responses, reactive oxygen species production, and apoptosis in I/R liver.	Reactive Oxygen Species	55-78	NLR family, pyrin domain containing 3	Mus musculus	0-5
24696236-10	2014	Furthermore, NLRP3(-/-) neutrophils decreased keratinocyte-derived chemokine-induced concentrations of intracellular calcium elevation, Rac activation, and actin assembly formation, thereby resulting in impaired migration activity.	Calcium	117-124	NLR family, pyrin domain containing 3	Mus musculus	13-18
24352154-7	2014	Surprisingly, fructose did not induce MetSyn but, irrespective of this, did induce Nlrp3-dependent renal inflammation.	Fructose	14-22	NLR family, pyrin domain containing 3	Mus musculus	83-88
24629563-13	2014	CONCLUSION: These results demonstrate that resveratrol ameliorates hepatic metaflammation, accompanied by alterations in NLRP3 inflammasome.	Resveratrol	43-54	NLR family, pyrin domain containing 3	Mus musculus	121-126
23886272-5	2014	CoQ10 deficiency induced by p-aminobenzoate treatment in blood mononuclear cells and mice showed NLRP3 inflammasome activation with marked algesia.	para-Aminobenzoates	28-43	NLR family, pyrin domain containing 3	Mus musculus	97-102
23771404-9	2014	Treatment of wild-type mice with the K-ATP channel opener iptakalim (IPT) could protect against LPS-induced liver injury through attenuating NLRP3 inflammasome-mediated inflammatory responses.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	58-67	NLR family, pyrin domain containing 3	Mus musculus	141-146
23771404-9	2014	Treatment of wild-type mice with the K-ATP channel opener iptakalim (IPT) could protect against LPS-induced liver injury through attenuating NLRP3 inflammasome-mediated inflammatory responses.	N-(1-methylethyl)-1,1,2-trimethylpropylamine	69-72	NLR family, pyrin domain containing 3	Mus musculus	141-146
24703845-5	2014	Consequently, they overproduce reactive oxygen species (ROS) to potentiate secretion of proinflammatory cytokines by activating NLRP3 inflammasome.	Reactive Oxygen Species	31-54	NLR family, pyrin domain containing 3	Mus musculus	128-133
24703845-5	2014	Consequently, they overproduce reactive oxygen species (ROS) to potentiate secretion of proinflammatory cytokines by activating NLRP3 inflammasome.	Reactive Oxygen Species	56-59	NLR family, pyrin domain containing 3	Mus musculus	128-133
24336017-2	2014	Glyburide has NLRP3 inhibitory activity in vitro but requires very high doses in vivo, associated with hypoglycemia.	Glyburide	0-9	NLR family, pyrin domain containing 3	Mus musculus	14-19
24336017-5	2014	HL-1 cardiomyocytes were treated with lipopolysaccharide and ATP to induce the formation of the NLRP3 inflammasome, measured as increased caspase-1 activity and cell death, and 16673-34-0 prevented such effects.	Adenosine Triphosphate	61-64	NLR family, pyrin domain containing 3	Mus musculus	96-101
24336017-8	2014	CONCLUSIONS: The small molecule 16673-34-0, an intermediate substrate in the glyburide synthesis free of the cyclohexylurea moiety, inhibits the formation of the NLRP3 inflammasome in cardiomyocytes and limits the infarct size after myocardial ischemia-reperfusion in the mouse, without affecting glucose metabolism.	Glyburide	77-86	NLR family, pyrin domain containing 3	Mus musculus	162-167
24140862-7	2014	In vivo, scavenging of O2(-) by Tempol and removal of H2O2 by catalase substantially inhibited NLRP3 inflammasome formation and activation in glomeruli of hHcys mice as shown by reduced colocalization of NLRP3 with ASC or caspase-1 and inhibition of caspase-1 activation and IL-1beta production.	Hydrogen Peroxide	54-58	NLR family, pyrin domain containing 3	Mus musculus	95-100
24283717-9	2014	In parallel, NMDA triggered the expression of NOD-like receptor protein (NLRP3), activation of caspase-1, and release of IL-1beta and TNF-alpha in primary WT but not TKO Muller cultures.	N-Methylaspartate	13-17	NLR family, pyrin domain containing 3	Mus musculus	73-78
24587153-0	2014	Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.	luteolin-7-glucoside	0-11	NLR family, pyrin domain containing 3	Mus musculus	103-108
24587153-11	2014	The decreased levels of ROS induced by luteoloside was accompanied by decrease in expression of NLRP3 inflammasome resulting in decrease in proteolytic cleavage of caspase-1.	Reactive Oxygen Species	24-27	NLR family, pyrin domain containing 3	Mus musculus	96-101
24587153-11	2014	The decreased levels of ROS induced by luteoloside was accompanied by decrease in expression of NLRP3 inflammasome resulting in decrease in proteolytic cleavage of caspase-1.	luteolin-7-glucoside	39-50	NLR family, pyrin domain containing 3	Mus musculus	96-101
24587153-13	2014	Thus, luteoloside exerts its inhibitory effect on proliferation, invasion and metastasis of HCC cells through inhibition of NLRP3 inflammasome.	luteolin-7-glucoside	6-17	NLR family, pyrin domain containing 3	Mus musculus	124-129
24279434-8	2014	Pretreatment with the NLRP3 inflammasome inhibitor Ac-YVAD-CMK significantly abrogated the depressive-like behaviors induced by lipopolysaccharide.	ac-yvad	51-58	NLR family, pyrin domain containing 3	Mus musculus	22-27
23813842-5	2014	To study the presence and significance of NLRP3-initiated pyroptotic cell death, we separated hepatocytes from nonparenchymal cells and developed a novel flow-cytometry-based (fluorescence-activated cell sorting; FACS) strategy to detect and quantify pyroptosis in vivo based on detection of active caspase 1 (Casp1)- and propidium iodide (PI)-positive cells.	Propidium	322-338	NLR family, pyrin domain containing 3	Mus musculus	42-47
24273204-3	2014	We also determined whether mitochondrial reactive oxygen species (ROS) governed by mitochondrial permeability transition pores (mPTPs) would trigger NLRP3 inflammasome activation following ICH.	Reactive Oxygen Species	41-64	NLR family, pyrin domain containing 3	Mus musculus	149-154
24273204-3	2014	We also determined whether mitochondrial reactive oxygen species (ROS) governed by mitochondrial permeability transition pores (mPTPs) would trigger NLRP3 inflammasome activation following ICH.	Reactive Oxygen Species	66-69	NLR family, pyrin domain containing 3	Mus musculus	149-154
24273204-12	2014	In naive animals, rotenone administration induced mPTP formation, ROS generation, and NLRP3 inflammasome activation, which were then reduced by TRO-19622 or Mito-TEMPO.	Rotenone	18-26	NLR family, pyrin domain containing 3	Mus musculus	86-91
24273204-14	2014	Mitochondria ROS may be a major trigger of NLRP3 inflammasome activation.	Reactive Oxygen Species	13-16	NLR family, pyrin domain containing 3	Mus musculus	43-48
24140862-0	2014	Contribution of endogenously produced reactive oxygen species to the activation of podocyte NLRP3 inflammasomes in hyperhomocysteinemia.	Reactive Oxygen Species	38-61	NLR family, pyrin domain containing 3	Mus musculus	92-97
24140862-3	2014	However, it remains unknown which reactive oxygen species (ROS) are responsible for this activation of NLRP3 inflammasomes and how such action of ROS is controlled.	Reactive Oxygen Species	34-57	NLR family, pyrin domain containing 3	Mus musculus	103-108
24140862-3	2014	However, it remains unknown which reactive oxygen species (ROS) are responsible for this activation of NLRP3 inflammasomes and how such action of ROS is controlled.	Reactive Oxygen Species	59-62	NLR family, pyrin domain containing 3	Mus musculus	103-108
24140862-9	2014	In conclusion, endogenously produced O2(-) and H2O2 primarily contribute to NLRP3 inflammasome formation and activation in mouse glomeruli resulting in glomerular injury or consequent sclerosis during hHcys.	Superoxides	37-39	NLR family, pyrin domain containing 3	Mus musculus	76-81
24140862-9	2014	In conclusion, endogenously produced O2(-) and H2O2 primarily contribute to NLRP3 inflammasome formation and activation in mouse glomeruli resulting in glomerular injury or consequent sclerosis during hHcys.	Hydrogen Peroxide	47-51	NLR family, pyrin domain containing 3	Mus musculus	76-81
25015733-13	2014	ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs.	ros	0-3	NLR family, pyrin domain containing 3	Mus musculus	37-42
24475307-2	2014	Thus, the present study tested the hypothesis that activation of Nlrp3 inflammasomes by ATP, which is a classical non-lipid danger stimulus, enhances the migration of macrophage and increases lipids deposition in macrophages accelerating foam cell formation.	Adenosine Triphosphate	88-91	NLR family, pyrin domain containing 3	Mus musculus	65-70
24475307-3	2014	We first demonstrated that extracellular ATP (2.5 mM) markedly increased the formation and activation of Nlrp3 inflammasomes in bone marrow macrophages (BMMs) from wild type (Asc+/+) mice resulting in activation of caspase-1 and IL-1beta production.	Adenosine Triphosphate	41-44	NLR family, pyrin domain containing 3	Mus musculus	105-110
25015733-13	2014	ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs.	ros	0-3	NLR family, pyrin domain containing 3	Mus musculus	75-80
24876671-0	2014	Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice.	chrysophanic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	22-27
25054161-4	2014	Silica increased NLRP3 inflammasome activation and release of the proinflammatory cytokine, IL-1beta, to a greater extent in MARCO(-/-) AM compared to wild type (WT) AM.	Silicon Dioxide	0-6	NLR family, pyrin domain containing 3	Mus musculus	17-22
25054161-6	2014	The difference in sensitivity to LMP appears to be in cholesterol recycling since increasing cholesterol in AM by treatment with U18666A decreased silica-induced NLRP3 inflammasome activation, and cells lacking MARCO were less able to sequester cholesterol following silica treatment.	Cholesterol	93-104	NLR family, pyrin domain containing 3	Mus musculus	162-167
25054161-6	2014	The difference in sensitivity to LMP appears to be in cholesterol recycling since increasing cholesterol in AM by treatment with U18666A decreased silica-induced NLRP3 inflammasome activation, and cells lacking MARCO were less able to sequester cholesterol following silica treatment.	Silicon Dioxide	147-153	NLR family, pyrin domain containing 3	Mus musculus	162-167
25054161-6	2014	The difference in sensitivity to LMP appears to be in cholesterol recycling since increasing cholesterol in AM by treatment with U18666A decreased silica-induced NLRP3 inflammasome activation, and cells lacking MARCO were less able to sequester cholesterol following silica treatment.	Cholesterol	93-104	NLR family, pyrin domain containing 3	Mus musculus	162-167
25171193-5	2014	The plasma Hcys levels were significantly elevated in both Nlrp3(-/-) and Nlrp3(+/+) mice fed a FF diet compared to ND fed mice.	Homocysteine	11-15	NLR family, pyrin domain containing 3	Mus musculus	59-64
25171193-5	2014	The plasma Hcys levels were significantly elevated in both Nlrp3(-/-) and Nlrp3(+/+) mice fed a FF diet compared to ND fed mice.	Homocysteine	11-15	NLR family, pyrin domain containing 3	Mus musculus	74-79
24876671-7	2014	The NALP3 inflammasome activation status and its dynamic expression during the natural inflammatory response induced by tMCAO were first profiled.	tmcao	120-125	NLR family, pyrin domain containing 3	Mus musculus	4-9
24876671-12	2014	Chrysophanol could inhibit the activation of NALP3 inflammasome and protect cerebral ischemic stroke.	chrysophanic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	45-50
23839951-0	2013	Functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation.	Carbon	21-27	NLR family, pyrin domain containing 3	Mus musculus	86-91
25214720-0	2014	Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	30-35
25214720-0	2014	Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice.	Sodium Chloride	14-20	NLR family, pyrin domain containing 3	Mus musculus	30-35
23739234-0	2013	NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy.	Oxalates	81-88	NLR family, pyrin domain containing 3	Mus musculus	0-5
23994575-0	2013	NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1.	Galactosamine	33-48	NLR family, pyrin domain containing 3	Mus musculus	0-5
23994575-4	2013	This study examined activation of the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome in GalN/LPS-induced hepatic injury and the role of HO-1 in the signaling pathways of inflammasome.	Galactosamine	110-114	NLR family, pyrin domain containing 3	Mus musculus	87-92
23994575-10	2013	Hepatic mRNA levels of TNF-alpha, IL-1beta, and NLRP3 increased after GalN/LPS treatment, and hemin attenuated increases in TNF-alpha and IL-1beta.	Galactosamine	70-74	NLR family, pyrin domain containing 3	Mus musculus	48-53
23994575-11	2013	After GalN/LPS treatment, the hepatic expression of NLRP3, ASC, and caspase-1 (p10) was increased.	Galactosamine	6-10	NLR family, pyrin domain containing 3	Mus musculus	52-57
24163412-9	2013	Expression of Nlrp3 and activation of caspase-1 were increased in PGN+poly(I:C)-treated uterus, which could induce pyroptosis.	Poly I-C	70-79	NLR family, pyrin domain containing 3	Mus musculus	14-19
24223129-7	2013	Cathepsin B activity, K(+) efflux, Ca(2+) influx and ROS production were all required for the NLRP3 inflammasome activation by M.hy.	ros	53-56	NLR family, pyrin domain containing 3	Mus musculus	94-99
23843215-7	2013	Up-regulated expression of NLRP3 and pro-caspase 1, post-translational processing of pro-caspase-1, and release of IL-18 in response to lipopolysaccharide + 2"(3")-O-(4-benzoylbenzoyl)ATP were attenuated by P2X7 R silencing in cultured mouse podocytes.	2"(3")-o-(4-benzoylbenzoyl)atp	157-187	NLR family, pyrin domain containing 3	Mus musculus	27-32
24022661-8	2013	Blockade of P2X7 activation by BBG suppressed NLRP3/ASC/caspase 1 assembly and the subsequent release of interleukin-1beta (IL-1beta), resulting in a significant reduction in the severity of nephritis and circulating anti-dsDNA antibodies.	coomassie Brilliant Blue	31-34	NLR family, pyrin domain containing 3	Mus musculus	46-51
23994575-13	2013	GalN/LPS induced expression of the thioredoxin-interacting protein (TXNIP) gene and the interaction between NLRP3 and TXNIP; again, hemin attenuated these effects.	Galactosamine	0-4	NLR family, pyrin domain containing 3	Mus musculus	108-113
23994575-13	2013	GalN/LPS induced expression of the thioredoxin-interacting protein (TXNIP) gene and the interaction between NLRP3 and TXNIP; again, hemin attenuated these effects.	Hemin	132-137	NLR family, pyrin domain containing 3	Mus musculus	108-113
23994575-15	2013	Our findings suggest that activation of the NLRP3 inflammasome leads to a GalN/LPS-induced inflammatory response through TXNIP-NLRP3 interaction.	Galactosamine	74-78	NLR family, pyrin domain containing 3	Mus musculus	44-49
23994575-15	2013	Our findings suggest that activation of the NLRP3 inflammasome leads to a GalN/LPS-induced inflammatory response through TXNIP-NLRP3 interaction.	Galactosamine	74-78	NLR family, pyrin domain containing 3	Mus musculus	127-132
23994575-16	2013	Furthermore, HO-1 overexpression may protect the liver against GalN/LPS-induced inflammation through suppression of the NLRP3 signaling pathway.	Galactosamine	63-67	NLR family, pyrin domain containing 3	Mus musculus	120-125
23739234-6	2013	Mice fed the diet high in soluble oxalate demonstrated increased NALP3 expression in the kidney.	Oxalates	34-41	NLR family, pyrin domain containing 3	Mus musculus	65-70
23739234-7	2013	Nalp3-null mice were completely protected from the progressive renal failure and death that occurred in wild-type mice fed the diet high in soluble oxalate.	Oxalates	148-155	NLR family, pyrin domain containing 3	Mus musculus	0-5
24204969-8	2013	The results suggest that osthole exerts its reno-protective effects on the progression of IgAN by inhibiting ROS production and activation of NF-kappaB and the NLRP3 inflammasome in the kidney.	osthol	25-32	NLR family, pyrin domain containing 3	Mus musculus	160-165
24204969-0	2013	Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kappaB/NLRP3 pathway.	osthol	0-7	NLR family, pyrin domain containing 3	Mus musculus	109-114
24116148-0	2013	Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.	polyenylpyrrole	0-15	NLR family, pyrin domain containing 3	Mus musculus	36-41
24116148-0	2013	Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression by reducing reactive oxygen species production and mitogen-activated protein kinase activation.	Reactive Oxygen Species	115-138	NLR family, pyrin domain containing 3	Mus musculus	36-41
24116148-6	2013	Compound 1h also reduced secretion of IL-6 and tumor necrosis factor-alpha by LPS-activated J774A.1 murine macrophage cells, primary mice peritoneal macrophages, and JAWSII murine bone marrow-derived dendritic cells and reduced NLRP3 inflammasome-mediated interleukin-1beta (IL-1beta) secretion by LPS + adenosine triphosphate-activated J774A.1 and JAWSII cells.	Hydrogen	9-11	NLR family, pyrin domain containing 3	Mus musculus	228-233
24116148-9	2013	They also show how compound 1h regulates inflammation and suggest it may be a new source for the development of anti-inflammatory agents to ameliorate inflammation- and NLRP3 inflammasome-related diseases.	Hydrogen	28-30	NLR family, pyrin domain containing 3	Mus musculus	169-174
23980097-3	2013	In this study, we show that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular pattern uric acid contribute to Nlrp3 inflammasome-mediated IL-1beta production and that gastrointestinal decontamination and uric acid depletion reduced GvHD severity.	Uric Acid	131-140	NLR family, pyrin domain containing 3	Mus musculus	155-160
24124509-6	2013	Impaired cytokine expression and NLR family, pyrin domain-containing 3 (NLRP3) inflammasome activation was seen in mice treated with creosol.	creosol	133-140	NLR family, pyrin domain containing 3	Mus musculus	33-70
24124509-6	2013	Impaired cytokine expression and NLR family, pyrin domain-containing 3 (NLRP3) inflammasome activation was seen in mice treated with creosol.	creosol	133-140	NLR family, pyrin domain containing 3	Mus musculus	72-77
24052904-6	2013	Moreover, increased caspase-1 dependent IL-1beta secretion with increased expression of NLRP3 inflammasome and phospho-NFkappaBp65 were observed in LGALS3(-/-) peritoneal macrophages stimulated in vitro by lipopolysaccharide and/or saturated fatty acid palmitate.	saturated fatty acid palmitate	232-262	NLR family, pyrin domain containing 3	Mus musculus	88-93
24003916-4	2013	NLRP3 inflammasome inducers reduce the NAD(+) level to inactivate the alpha-tubulin deacetylase Sirtuin 2, resulting in accumulation of acetylated alpha-tubulin.	NAD	39-45	NLR family, pyrin domain containing 3	Mus musculus	0-5
23770281-0	2013	Bay11-7082 attenuates murine lupus nephritis via inhibiting NLRP3 inflammasome and NF-kappaB activation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-10	NLR family, pyrin domain containing 3	Mus musculus	60-65
23770281-2	2013	In vitro data have shown that Bay11-7082 selectively inhibits NLRP3 inflammasome activity independent of NF-kappaB activity.	3-(4-methylphenylsulfonyl)-2-propenenitrile	30-40	NLR family, pyrin domain containing 3	Mus musculus	62-67
23770281-7	2013	Bay11-7082 treatment inhibited renal NLRP3 inflammasome formation and NF-kappaB activation in vivo.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-10	NLR family, pyrin domain containing 3	Mus musculus	37-42
23770281-11	2013	This study suggests that dual inhibition of NLRP3 inflammasome and NF-kappaB activation using Bay11-7082 or its analogues may be a promising therapeutic strategy for preventing the progression of LN.	3-(4-methylphenylsulfonyl)-2-propenenitrile	94-104	NLR family, pyrin domain containing 3	Mus musculus	44-49
23619996-3	2013	Here, we tried to identify new pathways regulated by the NLRP3 inflammasome in murine dendritic cells (DCs) in response to monosodium urate (MSU) crystals.	Uric Acid	123-139	NLR family, pyrin domain containing 3	Mus musculus	57-62
24067228-0	2013	[Expression of NLRP3 inflammasome in BALB/c mice with imiquimod-induced psoriasis-like inflammation and therapeutic effect of mustard seed (Sinapis Alba Linn)].	Imiquimod	54-63	NLR family, pyrin domain containing 3	Mus musculus	15-20
23838163-7	2013	CONCLUSIONS: Atheroprone flow induces NLRP3 inflammasome in endothelium through SREBP2 activation.	atheroprone	13-24	NLR family, pyrin domain containing 3	Mus musculus	38-43
23833276-9	2013	NLRP3(-/-) mice with ischemic AKI had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls.	Urea	64-68	NLR family, pyrin domain containing 3	Mus musculus	0-5
23833276-9	2013	NLRP3(-/-) mice with ischemic AKI had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls.	Nitrogen	69-77	NLR family, pyrin domain containing 3	Mus musculus	0-5
23833276-9	2013	NLRP3(-/-) mice with ischemic AKI had significantly lower blood urea nitrogen, serum creatinine, and acute tubular necrosis and apoptosis scores than the wild-type controls.	Creatinine	85-95	NLR family, pyrin domain containing 3	Mus musculus	0-5
23915129-0	2013	Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines.	mitoquinone	34-39	NLR family, pyrin domain containing 3	Mus musculus	94-99
23915129-10	2013	By decreasing mitochondrial reactive oxygen species, MitoQ also suppressed activation of the NLRP3 inflammasome that was responsible for maturation of IL-1 beta and IL-18.	mitoquinone	53-58	NLR family, pyrin domain containing 3	Mus musculus	93-98
23619996-3	2013	Here, we tried to identify new pathways regulated by the NLRP3 inflammasome in murine dendritic cells (DCs) in response to monosodium urate (MSU) crystals.	Uric Acid	141-144	NLR family, pyrin domain containing 3	Mus musculus	57-62
23619996-5	2013	Upon exposure to MSU or other ROS-mobilizing stimuli (rotenone and gamma-radiation), DNA fragmentation was markedly ameliorated in Nlrp3(-/-) and casp-1(-/-) DCs compared with WT DCs.	ros	30-33	NLR family, pyrin domain containing 3	Mus musculus	131-136
23619996-5	2013	Upon exposure to MSU or other ROS-mobilizing stimuli (rotenone and gamma-radiation), DNA fragmentation was markedly ameliorated in Nlrp3(-/-) and casp-1(-/-) DCs compared with WT DCs.	Rotenone	54-62	NLR family, pyrin domain containing 3	Mus musculus	131-136
23619996-6	2013	Moreover, Nlrp3(-/-) DCs experienced significantly less oxidative DNA damage mediated by ROS.	ros	89-92	NLR family, pyrin domain containing 3	Mus musculus	10-15
23349493-7	2013	Transfection of LGALS3(-/-) macrophages with NLRP3 small interfering RNA attenuated IL-1beta production in response to palmitate and LPS plus palmitate.	Palmitates	119-128	NLR family, pyrin domain containing 3	Mus musculus	45-50
23567192-0	2013	Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome.	antroquinonol	0-13	NLR family, pyrin domain containing 3	Mus musculus	143-148
23567192-6	2013	Further mechanistic analysis in AcP-IgAN mice showed that, early in the developmental stage of the AcP-IgAN model, Antroq promoted the Nrf2 antioxidant pathway and inhibited the activation of T cells and NLRP3 inflammasome.	antroquinonol	115-121	NLR family, pyrin domain containing 3	Mus musculus	204-209
23567192-8	2013	In addition, Antroq was shown to inhibit activation of NLRP3 inflammasome in vitro by an IgA immune complex (IC) partly involving a reduced ROS production in IgA-IC-primed macrophages, and this finding may be helpful in the understanding of the mode of action of Antroq in the treated AcP-IgAN mice.	antroquinonol	13-19	NLR family, pyrin domain containing 3	Mus musculus	55-60
23567192-8	2013	In addition, Antroq was shown to inhibit activation of NLRP3 inflammasome in vitro by an IgA immune complex (IC) partly involving a reduced ROS production in IgA-IC-primed macrophages, and this finding may be helpful in the understanding of the mode of action of Antroq in the treated AcP-IgAN mice.	Reactive Oxygen Species	140-143	NLR family, pyrin domain containing 3	Mus musculus	55-60
23567192-8	2013	In addition, Antroq was shown to inhibit activation of NLRP3 inflammasome in vitro by an IgA immune complex (IC) partly involving a reduced ROS production in IgA-IC-primed macrophages, and this finding may be helpful in the understanding of the mode of action of Antroq in the treated AcP-IgAN mice.	antroquinonol	263-269	NLR family, pyrin domain containing 3	Mus musculus	55-60
24009541-0	2013	Cobalt Chloride-induced Hypoxia Ameliorates NLRP3-Mediated Caspase-1 Activation in Mixed Glial Cultures.	cobaltous chloride	0-15	NLR family, pyrin domain containing 3	Mus musculus	44-49
24009541-4	2013	Of particular interest, CoCl2-induced hypoxic condition considerably inhibited NLRP3-dependent caspase-1 activation in mixed glial cells, but not in bone marrow-derived macrophages.	cobaltous chloride	24-29	NLR family, pyrin domain containing 3	Mus musculus	79-84
24009541-5	2013	CoCl2-mediated inhibition of NLRP3 inflammasome activity was also observed in the isolated brain microglial cells, but CoCl2 did not affect poly dA:dT-triggered AIM2 inflammasome activity in mixed glial cells.	cobaltous chloride	0-5	NLR family, pyrin domain containing 3	Mus musculus	29-34
24009541-6	2013	Our results collectively demonstrate that CoCl2-induced hypoxia may negatively regulate NLRP3 inflammasome signaling in brain glial cells, but its physiological significance remains to be determined.	cobaltous chloride	42-47	NLR family, pyrin domain containing 3	Mus musculus	88-93
23636457-2	2013	Nucleotide-binding domain and leucine-rich repeat PYD-containing protein 3 (NLRP3) senses the ROS, triggering inflammasome activation and interleukin-1beta (IL-1beta) production and secretion.	Reactive Oxygen Species	94-97	NLR family, pyrin domain containing 3	Mus musculus	76-81
23636457-9	2013	Taken together, this research demonstrates for the first time that NLRP3-deficient mice have suppressed inflammatory response and blunted lung epithelial cell apoptosis to HALI.	hali	172-176	NLR family, pyrin domain containing 3	Mus musculus	67-72
23376234-2	2013	Several identified Nlrp3 inflammasome activators also trigger reactive oxygen species (ROS) production.	Reactive Oxygen Species	62-85	NLR family, pyrin domain containing 3	Mus musculus	19-24
23376234-2	2013	Several identified Nlrp3 inflammasome activators also trigger reactive oxygen species (ROS) production.	Reactive Oxygen Species	87-90	NLR family, pyrin domain containing 3	Mus musculus	19-24
23376234-5	2013	In this study, we explore the impact of mitochondria dysfunction and ROS production on Nlrp3 inflammasome stimulation and IL-1beta secretion induced by serum amyloid A (SAA) in primary mouse peritoneal macrophages.	Reactive Oxygen Species	69-72	NLR family, pyrin domain containing 3	Mus musculus	87-92
23376234-11	2013	We also found that mitochondria-targeted drugs increased IL-1beta secretion regardless of their impact on mitochondrial function and ROS levels, suggesting that mitochondrial ROS-dependent and -independent mechanisms play a role in the Nlrp3 inflammasome/IL-1beta secretion axis in SAA-stimulated cells.	Reactive Oxygen Species	175-178	NLR family, pyrin domain containing 3	Mus musculus	236-241
23376234-12	2013	Finally, we found that FCCP significantly sustained the association of the Nlrp3 inflammasome complex, which could explain the most robust effect among the drugs tested in enhancing IL-1beta secretion in SAA-treated cells.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	23-27	NLR family, pyrin domain containing 3	Mus musculus	75-80
23376234-13	2013	Overall, our data suggest that the Nlrp3 inflammasome/IL-1beta secretion axis is a very highly regulated inflammatory pathway that is susceptible not only to changes in mitochondrial or intracellular ROS, but also to changes in overall mitochondrial function.	Reactive Oxygen Species	200-203	NLR family, pyrin domain containing 3	Mus musculus	35-40
23625200-0	2013	Alcohol-induced IL-1beta in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation.	Alcohols	0-7	NLR family, pyrin domain containing 3	Mus musculus	53-58
23625200-6	2013	Expression of inflammasome components (NLRP1, NLRP3, ASC) and proinflammatory cytokines (TNF-alpha, MCP-1) was increased in brains of alcohol-fed compared with control mice.	Alcohols	134-141	NLR family, pyrin domain containing 3	Mus musculus	46-51
23625200-11	2013	NLRP3- or ASC-deficient mice were protected from caspase-1 activation and alcohol-induced IL-1beta increase in the brain.	Alcohols	74-81	NLR family, pyrin domain containing 3	Mus musculus	0-5
23625200-14	2013	In conclusion, alcohol up-regulates and activates the NLRP3/ASC inflammasome, leading to caspase-1 activation and IL-1beta increase in the cerebellum.	Alcohols	15-22	NLR family, pyrin domain containing 3	Mus musculus	54-59
23583630-0	2013	Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.	thymoquinone	0-12	NLR family, pyrin domain containing 3	Mus musculus	70-75
23583630-4	2013	We have assessed whether thymoquinone inhibits metastasis of melanoma cells by targeting NLRP3 subunit of inflammasomes.	thymoquinone	25-37	NLR family, pyrin domain containing 3	Mus musculus	89-94
23583630-7	2013	The inhibition of migration of melanoma cells by thymoquinone was accompanied by a decrease in expression of NLRP3 inflammasome resulting in decrease in proteolytic cleavage of caspase-1.	thymoquinone	49-61	NLR family, pyrin domain containing 3	Mus musculus	109-114
23583630-10	2013	Furthermore, inhibition of reactive oxygen species (ROS) by thymoquinone resulted in partial inactivation of NLRP3 inflammasome.	Reactive Oxygen Species	27-50	NLR family, pyrin domain containing 3	Mus musculus	109-114
23583630-10	2013	Furthermore, inhibition of reactive oxygen species (ROS) by thymoquinone resulted in partial inactivation of NLRP3 inflammasome.	Reactive Oxygen Species	52-55	NLR family, pyrin domain containing 3	Mus musculus	109-114
23583630-10	2013	Furthermore, inhibition of reactive oxygen species (ROS) by thymoquinone resulted in partial inactivation of NLRP3 inflammasome.	thymoquinone	60-72	NLR family, pyrin domain containing 3	Mus musculus	109-114
23583630-11	2013	Thus, thymoquinone exerts its inhibitory effect on migration of human and mouse melanoma cells by inhibition of NLRP3 inflammasome.	thymoquinone	6-18	NLR family, pyrin domain containing 3	Mus musculus	112-117
23506741-0	2013	A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome.	benzo[d]imidazole	8-25	NLR family, pyrin domain containing 3	Mus musculus	140-145
23609011-4	2013	We examined the potential co-localization of NLRP3 inflammasome with mitochondria and seven other organelles under adenosine triphosphate, nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal microscopy approach.	Nigericin	139-148	NLR family, pyrin domain containing 3	Mus musculus	45-50
23609011-4	2013	We examined the potential co-localization of NLRP3 inflammasome with mitochondria and seven other organelles under adenosine triphosphate, nigericin or monosodium urate stimulation in mouse peritoneal macrophages using confocal microscopy approach.	Uric Acid	152-168	NLR family, pyrin domain containing 3	Mus musculus	45-50
23717478-0	2013	Adenosine-5"-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome.	Adenosine Triphosphate	0-25	NLR family, pyrin domain containing 3	Mus musculus	95-100
23717478-0	2013	Adenosine-5"-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome.	Adenosine Triphosphate	27-30	NLR family, pyrin domain containing 3	Mus musculus	95-100
23717478-1	2013	It has been established that Adenosine-5"-triphosphate (ATP) can activate the NLRP3 inflammasome.	Adenosine Triphosphate	29-54	NLR family, pyrin domain containing 3	Mus musculus	78-83
23717478-1	2013	It has been established that Adenosine-5"-triphosphate (ATP) can activate the NLRP3 inflammasome.	Adenosine Triphosphate	56-59	NLR family, pyrin domain containing 3	Mus musculus	78-83
23717478-2	2013	However, the physiological effect of extracellular ATP on NLRP3 inflammasome activation has not yet been investigated.	Adenosine Triphosphate	51-54	NLR family, pyrin domain containing 3	Mus musculus	58-63
23717478-10	2013	In the present study, we demonstrated a protective role for ATP during bacterial infection and this effect was related to NLRP3 inflammasome activation.	Adenosine Triphosphate	60-63	NLR family, pyrin domain containing 3	Mus musculus	122-127
23506741-0	2013	A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome.	Dextran Sulfate	63-85	NLR family, pyrin domain containing 3	Mus musculus	140-145
23506741-3	2013	In the present study, we aimed at examining the effect of 1-ethyl-5-methyl-2-phenyl-1H-benzo[d]imidazole, a synthetic small molecular compound also named Fc11a-2, for the treatment of dextran sulfate sodium (DSS)-induced experimental colitis in mice via targeting NLRP3 inflammasome.	CHEMBL4443648	58-104	NLR family, pyrin domain containing 3	Mus musculus	264-269
23240585-8	2013	Hypoxic exposure increased PH, vascular remodeling, and NALP3 inflammasome activation in PBS-treated mice, while mice treated with MnTE-2-PyP showed an attenuation in each of these endpoints.	pbs	89-92	NLR family, pyrin domain containing 3	Mus musculus	56-61
22921586-0	2013	The mycobacterial cord factor adjuvant analogue trehalose-6,6"-dibehenate (TDB) activates the Nlrp3 inflammasome.	trehalose 6,6'-dibehenate	48-73	NLR family, pyrin domain containing 3	Mus musculus	94-99
23088210-2	2013	The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated redox signaling contributes to homocysteine (Hcys)-induced activation of NALP3 inflammasomes, an intracellular inflammatory machinery in podocytes in vitro and in vivo.	nicotinamide adenine	47-67	NLR family, pyrin domain containing 3	Mus musculus	189-194
23088210-2	2013	The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated redox signaling contributes to homocysteine (Hcys)-induced activation of NALP3 inflammasomes, an intracellular inflammatory machinery in podocytes in vitro and in vivo.	Homocysteine	147-159	NLR family, pyrin domain containing 3	Mus musculus	189-194
23088210-2	2013	The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-mediated redox signaling contributes to homocysteine (Hcys)-induced activation of NALP3 inflammasomes, an intracellular inflammatory machinery in podocytes in vitro and in vivo.	Homocysteine	161-165	NLR family, pyrin domain containing 3	Mus musculus	189-194
23088210-9	2013	CONCLUSION: Hcys-induced NADPH oxidase activation is importantly involved in the switching on of NALP3 inflammasomes within podocytes, which leads to the downstream recruitment of immune cells, ultimately resulting in glomerular injury and sclerosis.	Homocysteine	12-16	NLR family, pyrin domain containing 3	Mus musculus	97-102
23406388-0	2013	Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-kappaB and NLRP3 inflammasome activation.	artemisinin	18-29	NLR family, pyrin domain containing 3	Mus musculus	156-161
23406388-5	2013	RESULTS: We found that artemisinin treatment (1) decreased neuritic plaque burden; (2) did not alter Abeta transport across the blood-brain barrier; (3) regulated APP processing via inhibiting beta-secretase activity; (4) inhibited NF-kappaB activity and NALP3 inflammasome activation in APPswe/PS1dE9 double transgenic mice.	artemisinin	23-34	NLR family, pyrin domain containing 3	Mus musculus	255-260
23406388-6	2013	CONCLUSIONS: The in vivo study clearly demonstrates that artemisinin has protective effects on AD pathology due to its effects on suppressing NF-kappaB activity and NALP3 inflammasome activation.	artemisinin	57-68	NLR family, pyrin domain containing 3	Mus musculus	165-170
22921586-0	2013	The mycobacterial cord factor adjuvant analogue trehalose-6,6"-dibehenate (TDB) activates the Nlrp3 inflammasome.	trehalose 6,6'-dibehenate	75-78	NLR family, pyrin domain containing 3	Mus musculus	94-99
23103566-8	2013	Thus, we demonstrate for the first time that the specific PPAR-delta agonist GW0742 attenuates the metabolic abnormalities and the renal dysfunction/inflammation caused by chronic HFCS-55 exposure by preventing upregulation of fructokinase (liver) and activation of the NLRP3 inflammasome (kidney).	GW0742	77-83	NLR family, pyrin domain containing 3	Mus musculus	270-275
23427251-4	2013	In vitro studies show that Nlrp3 inflammasome activation is enhanced by Gabarap deficiency, as evidenced by more casapse-1 activation, more IL-1beta, and more IL-18 secretion in LPS- and ATP-treated Gabarap(-/-) macrophages.	Adenosine Triphosphate	187-190	NLR family, pyrin domain containing 3	Mus musculus	27-32
23436933-5	2013	We also observed that NADPH oxidase subunit gp91(phox) was dispensable for stretch-induced cytokine production, whereas mitochondrial generation of reactive oxygen species was required for stretch-induced NLRP3 inflammasome activation and IL-1beta release.	Reactive Oxygen Species	148-171	NLR family, pyrin domain containing 3	Mus musculus	205-210
23387472-6	2013	Up-regulation of NLRP3 mRNA by UV was also found to be dependent on UV-induced uric acid.	Uric Acid	79-88	NLR family, pyrin domain containing 3	Mus musculus	17-22
23387472-7	2013	This suggested that the target of UV-induced uric acid included proteins involved in the formation and activation of the NLRP3-inflammasome.	Uric Acid	45-54	NLR family, pyrin domain containing 3	Mus musculus	121-126
23318584-0	2013	Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock.	Nitric Oxide	0-12	NLR family, pyrin domain containing 3	Mus musculus	24-29
23318584-2	2013	Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1beta secretion in myeloid cells from both mice and humans.	Nitric Oxide	18-30	NLR family, pyrin domain containing 3	Mus musculus	50-55
23711138-2	2013	In this study, the methanolic extract of WS(mWS) was tested for its electrical influence on hippocampal CA1 pyramidal neurons using a patch clamp technique.	methanolic	19-29	NLR family, pyrin domain containing 3	Mus musculus	41-43
24117067-5	2013	The mWS induced currents were blocked by picrotoxin, a GABAA receptor antagonist.	Picrotoxin	41-51	NLR family, pyrin domain containing 3	Mus musculus	4-7
23711138-2	2013	In this study, the methanolic extract of WS(mWS) was tested for its electrical influence on hippocampal CA1 pyramidal neurons using a patch clamp technique.	methanolic	19-29	NLR family, pyrin domain containing 3	Mus musculus	44-47
24117067-3	2013	In whole-cell patch clamp mode, methanol extract of Withania somnifera (mWS) induced short-lived and repeatable inward currents in all SG neurons tested (31.3 +- 8.51 pA, n = 7) using a high chloride pipette solution.	Methanol	32-40	NLR family, pyrin domain containing 3	Mus musculus	72-75
23711138-3	2013	In current clamp mode under a high chloride pipette solution, mWS (400 ng/mul) induced remarkable membrane depolarization (9.75 +- 2.54 mV, n = 6) of CA1 neurons.	Chlorides	35-43	NLR family, pyrin domain containing 3	Mus musculus	62-65
24117067-3	2013	In whole-cell patch clamp mode, methanol extract of Withania somnifera (mWS) induced short-lived and repeatable inward currents in all SG neurons tested (31.3 +- 8.51 pA, n = 7) using a high chloride pipette solution.	Chlorides	191-199	NLR family, pyrin domain containing 3	Mus musculus	72-75
24117067-4	2013	The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Na (+) channel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist.	Tetrodotoxin	95-107	NLR family, pyrin domain containing 3	Mus musculus	4-7
23711138-4	2013	The mWS-induced depolarization was dose-dependent, reproducible, and persistent in the presence of 0.5 muM tetrodotoxin (TTX, 10.17 +- 0.04 mV, n = 6).	Tetrodotoxin	107-119	NLR family, pyrin domain containing 3	Mus musculus	4-7
24117067-4	2013	The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Na (+) channel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist.	Tetrodotoxin	109-112	NLR family, pyrin domain containing 3	Mus musculus	4-7
24117067-4	2013	The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Na (+) channel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist.	6-Cyano-7-nitroquinoxaline-2,3-dione	155-159	NLR family, pyrin domain containing 3	Mus musculus	4-7
24117067-4	2013	The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Na (+) channel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist.	2-amino-5-phosphopentanoic acid	203-206	NLR family, pyrin domain containing 3	Mus musculus	4-7
24117067-4	2013	The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Na (+) channel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist.	Strychnine	240-250	NLR family, pyrin domain containing 3	Mus musculus	4-7
23711138-4	2013	The mWS-induced depolarization was dose-dependent, reproducible, and persistent in the presence of 0.5 muM tetrodotoxin (TTX, 10.17 +- 0.04 mV, n = 6).	Tetrodotoxin	121-124	NLR family, pyrin domain containing 3	Mus musculus	4-7
23711138-5	2013	In voltage clamp mode (holding potential = -60 mV), mWS induced a dose-dependent non-desensitizing inward current that persisted in the presence of TTX (0.5 muM), suggesting that the response induced by mWS was purely a postsynaptic event.	Tetrodotoxin	148-151	NLR family, pyrin domain containing 3	Mus musculus	52-55
23711138-5	2013	In voltage clamp mode (holding potential = -60 mV), mWS induced a dose-dependent non-desensitizing inward current that persisted in the presence of TTX (0.5 muM), suggesting that the response induced by mWS was purely a postsynaptic event.	Tetrodotoxin	148-151	NLR family, pyrin domain containing 3	Mus musculus	203-206
23711138-7	2013	Further, mWS potentiated the NMDA response in hippocampal CA1 neurons at low concentrations.	N-Methylaspartate	29-33	NLR family, pyrin domain containing 3	Mus musculus	9-12
23711138-8	2013	Overall, these results suggest that there are compounds in WS with possible glycine mimetic activities, which may be potential targets for inducing memory consolidation in hippocampal CA1 neurons.	Glycine	76-83	NLR family, pyrin domain containing 3	Mus musculus	59-61
22986467-2	2013	However, the ROS-mediated signaling pathways controlling NLRP3 inflammasome activation are not well defined.	Reactive Oxygen Species	13-16	NLR family, pyrin domain containing 3	Mus musculus	57-62
23839341-0	2013	Pirfenidone attenuates cardiac fibrosis in a mouse model of TAC-induced left ventricular remodeling by suppressing NLRP3 inflammasome formation.	pirfenidone	0-11	NLR family, pyrin domain containing 3	Mus musculus	115-120
23839341-6	2013	The inhibition of NLRP3 expression by pirfenidone attenuated the expression of IL-1beta and IL-1beta-induced inflammatory and profibrotic responses.	pirfenidone	38-49	NLR family, pyrin domain containing 3	Mus musculus	18-23
23839341-7	2013	CONCLUSIONS: Pirfenidone may be useful in the treatment of hypertension-induced myocardial fibrosis by inhibiting NLRP3-induced inflammation and fibrosis.	pirfenidone	13-24	NLR family, pyrin domain containing 3	Mus musculus	114-119
22986467-0	2013	Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1beta secretion.	Adenosine Triphosphate	19-41	NLR family, pyrin domain containing 3	Mus musculus	92-97
22986467-1	2013	OBJECTIVE: Reactive oxygen species (ROS) plays a critical role in the regulation of NLRP3 inflammasome activation.	Reactive Oxygen Species	11-34	NLR family, pyrin domain containing 3	Mus musculus	84-89
22986467-5	2013	RESULTS: LPS-induced NLRP3 protein expression was regulated through the NADPH oxidase/ROS/NF-kappaB-dependent, JAK2/PI3-kinase/AKT/NF-kappaB-dependent, and MAPK-dependent pathways, while ATP-induced caspase-1 activation was regulated through the NADPH oxidase/ROS-dependent pathway.	Reactive Oxygen Species	86-89	NLR family, pyrin domain containing 3	Mus musculus	21-26
22986467-1	2013	OBJECTIVE: Reactive oxygen species (ROS) plays a critical role in the regulation of NLRP3 inflammasome activation.	Reactive Oxygen Species	36-39	NLR family, pyrin domain containing 3	Mus musculus	84-89
22986467-5	2013	RESULTS: LPS-induced NLRP3 protein expression was regulated through the NADPH oxidase/ROS/NF-kappaB-dependent, JAK2/PI3-kinase/AKT/NF-kappaB-dependent, and MAPK-dependent pathways, while ATP-induced caspase-1 activation was regulated through the NADPH oxidase/ROS-dependent pathway.	Adenosine Triphosphate	187-190	NLR family, pyrin domain containing 3	Mus musculus	21-26
22986467-5	2013	RESULTS: LPS-induced NLRP3 protein expression was regulated through the NADPH oxidase/ROS/NF-kappaB-dependent, JAK2/PI3-kinase/AKT/NF-kappaB-dependent, and MAPK-dependent pathways, while ATP-induced caspase-1 activation was regulated through the NADPH oxidase/ROS-dependent pathway.	Reactive Oxygen Species	260-263	NLR family, pyrin domain containing 3	Mus musculus	21-26
22986467-6	2013	CONCLUSIONS: These results demonstrate that ROS regulates not only the priming stage, but also the activation stage, of NLRP3 inflammasome activation in LPS + ATP-activated macrophages.	Reactive Oxygen Species	44-47	NLR family, pyrin domain containing 3	Mus musculus	120-125
22986467-6	2013	CONCLUSIONS: These results demonstrate that ROS regulates not only the priming stage, but also the activation stage, of NLRP3 inflammasome activation in LPS + ATP-activated macrophages.	Adenosine Triphosphate	159-162	NLR family, pyrin domain containing 3	Mus musculus	120-125
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	63-74	NLR family, pyrin domain containing 3	Mus musculus	181-186
23221343-0	2013	Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1beta secretion.	Calcium Oxalate	0-15	NLR family, pyrin domain containing 3	Mus musculus	54-59
23221343-7	2013	These data demonstrated that CaOx crystals trigger IL-1beta-dependent innate immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tubular cells, leading to the release of the NLRP3 agonist ATP.	Adenosine Triphosphate	235-238	NLR family, pyrin domain containing 3	Mus musculus	94-99
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Silicon Dioxide	266-272	NLR family, pyrin domain containing 3	Mus musculus	36-84
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Silicon Dioxide	266-272	NLR family, pyrin domain containing 3	Mus musculus	86-91
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Uric Acid	278-283	NLR family, pyrin domain containing 3	Mus musculus	36-84
22933241-2	2013	Several lines of evidence implicate NACHT, LRR, and PYD domains-containing protein 3 (NALP3) inflammasome-mediated production of interleukin 1 beta (IL-1beta) in the pathogenesis of clinical disorders ascribable to foreign particulate materials, including asbestos, silica, and urate crystals.	Uric Acid	278-283	NLR family, pyrin domain containing 3	Mus musculus	86-91
22933241-8	2013	Importantly, using macrophages from mice deficient in components of the NALP3 inflammasome, we show PMMA-induced IL-1beta production is strictly dependent on these components.	Polymethyl Methacrylate	100-104	NLR family, pyrin domain containing 3	Mus musculus	72-77
23852596-6	2013	More specifically, protocols are described for the preparation and differentiation of BMDCs, their priming and stimulation using particulate NLRP3 agonists such as monosodium urate monohydrate (MSU) and the vaccine adjuvant alum.	Uric Acid	164-192	NLR family, pyrin domain containing 3	Mus musculus	141-146
23852596-6	2013	More specifically, protocols are described for the preparation and differentiation of BMDCs, their priming and stimulation using particulate NLRP3 agonists such as monosodium urate monohydrate (MSU) and the vaccine adjuvant alum.	Uric Acid	194-197	NLR family, pyrin domain containing 3	Mus musculus	141-146
23511475-2	2013	Although mitochondrial reactive oxygen species have a central role in NLRP3 inflammasome activation, how reactive oxygen species signal assembly of the NLRP3 inflammasome remains elusive.	Reactive Oxygen Species	23-46	NLR family, pyrin domain containing 3	Mus musculus	70-75
23511475-2	2013	Although mitochondrial reactive oxygen species have a central role in NLRP3 inflammasome activation, how reactive oxygen species signal assembly of the NLRP3 inflammasome remains elusive.	Reactive Oxygen Species	105-128	NLR family, pyrin domain containing 3	Mus musculus	152-157
24453428-0	2013	Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice.	Alcohols	0-7	NLR family, pyrin domain containing 3	Mus musculus	45-50
24453428-9	2013	We conclude that the Nlrp3 inflammasome is protective during alcohol-induced liver injury.	Alcohols	61-68	NLR family, pyrin domain containing 3	Mus musculus	21-26
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	gemcitabine	76-79	NLR family, pyrin domain containing 3	Mus musculus	181-186
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	85-99	NLR family, pyrin domain containing 3	Mus musculus	181-186
23202296-3	2013	Here we show that two clinically used chemotherapeutic agents, gemcitabine (Gem) and 5-fluorouracil (5FU), activate the NOD-like receptor family, pyrin domain containing-3 protein (Nlrp3)-dependent caspase-1 activation complex (termed the inflammasome) in myeloid-derived suppressor cells (MDSCs), leading to production of interleukin-1beta (IL-1beta), which curtails anticancer immunity.	Fluorouracil	101-104	NLR family, pyrin domain containing 3	Mus musculus	181-186
23202296-6	2013	Accordingly, Gem and 5FU exerted higher antitumor effects when tumors were established in Nlrp3(-/-) or Casp1(-/-) mice or wild-type mice treated with interleukin-1 receptor antagonist (IL-1Ra).	Fluorouracil	21-24	NLR family, pyrin domain containing 3	Mus musculus	90-95
23171450-9	2012	This ROS activate NLRP3, and NLRP3 leads to the production of caspase-1, which subsequently increases IL-1beta, thereby finally inducing inflammation.	Reactive Oxygen Species	5-8	NLR family, pyrin domain containing 3	Mus musculus	18-23
23468973-4	2013	We aimed to clarify 1/ the role of BCP crystals in cartilage destruction and 2/ the role of IL-1 and NLRP3 inflammasome in cartilage degradation related to BCP crystals.	bcp	156-159	NLR family, pyrin domain containing 3	Mus musculus	101-106
22986947-3	2013	A recent study suggested that the purinergic receptor antagonist A438079 protects against APAP-induced liver injury by preventing the activation of the Nalp3 inflammasome in Kupffer cells and thereby preventing inflammatory injury.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	65-72	NLR family, pyrin domain containing 3	Mus musculus	152-157
23143333-4	2012	Here we show that the murine calcium-sensing receptor (CASR) activates the NLRP3 inflammasome, mediated by increased intracellular Ca(2+) and decreased cellular cyclic AMP (cAMP).	Cyclic AMP	161-171	NLR family, pyrin domain containing 3	Mus musculus	75-80
23143333-4	2012	Here we show that the murine calcium-sensing receptor (CASR) activates the NLRP3 inflammasome, mediated by increased intracellular Ca(2+) and decreased cellular cyclic AMP (cAMP).	Cyclic AMP	173-177	NLR family, pyrin domain containing 3	Mus musculus	75-80
23010656-0	2012	Hyaluronan activation of the Nlrp3 inflammasome contributes to the development of airway hyperresponsiveness.	Hyaluronic Acid	0-10	NLR family, pyrin domain containing 3	Mus musculus	29-34
23010656-12	2012	CONCLUSIONS: The Nlrp3 inflammasome is required for the development of ozone-induced reactive airways disease.	Ozone	71-76	NLR family, pyrin domain containing 3	Mus musculus	17-22
23228123-5	2012	However upon activation of the NLRP3 inflammasome with ATP, macrophages from young and aged mice were able to efficiently convert and secrete intracellular pro-cytokines as functional cytokines.	Adenosine Triphosphate	55-58	NLR family, pyrin domain containing 3	Mus musculus	31-36
23216160-0	2012	NLRP3 inflammasome activation in murine alveolar macrophages and related lung pathology is associated with MWCNT nickel contamination.	Nickel	113-119	NLR family, pyrin domain containing 3	Mus musculus	0-5
23216160-4	2012	MWCNT, from a variety of sources that differed primarily in overall purity and metal contaminants, were examined for their effects in vitro (toxicity and NLRP3 inflammasome activation using primary alveolar macrophages isolated from C57Bl/6 mice).	mwcnt	0-5	NLR family, pyrin domain containing 3	Mus musculus	154-159
23028046-12	2012	We found that LeTx caused NLRP1b/caspase-1-dependent mitochondrial dysfunction, including hyperpolarization and generation of reactive oxygen species, which was distinct from that induced by stimuli such as NLRP3-activating ATP.	Adenosine Triphosphate	224-227	NLR family, pyrin domain containing 3	Mus musculus	207-212
23010873-2	2012	The host sensor for asbestos-induced inflammation is the NLRP3 inflammasome and it is widely assumed that this complex is essential for asbestos-induced cancers.	Asbestos	20-28	NLR family, pyrin domain containing 3	Mus musculus	57-62
22986739-4	2012	The suppression of spontaneous and experimental tumor metastases and methylcholanthrene (MCA)-induced sarcomas in mice deficient for NLRP3 was NK cell and IFN-gamma-dependent.	Methylcholanthrene	69-87	NLR family, pyrin domain containing 3	Mus musculus	133-138
22986739-4	2012	The suppression of spontaneous and experimental tumor metastases and methylcholanthrene (MCA)-induced sarcomas in mice deficient for NLRP3 was NK cell and IFN-gamma-dependent.	Methylcholanthrene	89-92	NLR family, pyrin domain containing 3	Mus musculus	133-138
23010873-5	2012	Thus, early inflammatory reactions triggered by asbestos are NLRP3-dependent, but NLRP3 is not critical in the chronic development of asbestos-induced mesothelioma.	Asbestos	48-56	NLR family, pyrin domain containing 3	Mus musculus	61-66
22169929-0	2012	NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability.	Ceramides	41-49	NLR family, pyrin domain containing 3	Mus musculus	0-6
22904305-5	2012	In a second model of IL-1beta-driven inflammation, NLRP3 activation by monosodium urate crystals similarly increased IL-6.	Uric Acid	71-87	NLR family, pyrin domain containing 3	Mus musculus	51-56
22753929-6	2012	In contrast, muramyl dipeptide-mediated inflammasome formation is not dependent on NLRP1 but NLRP3.	Acetylmuramyl-Alanyl-Isoglutamine	13-30	NLR family, pyrin domain containing 3	Mus musculus	93-98
22882971-11	2012	CONCLUSIONS: In conclusion, non-crystalline silica particles in the nano- and submicro-size ranges seemed to induce IL-1beta release from LPS-primed RAW264.7 macrophages via similar mechanisms as crystalline silica, involving particle uptake, phagosomal leakage and activation of the NALP3 inflammasome.	Silicon Dioxide	44-50	NLR family, pyrin domain containing 3	Mus musculus	284-289
22882971-2	2012	Several reports have demonstrated that crystalline, but also non-crystalline silica particles induce IL-1beta release from macrophages via the NALP3-inflammasome complex (caspase-1, ASC and NALP3) in the presence of lipopolysaccharide (LPS) from bacteria.	Silicon Dioxide	77-83	NLR family, pyrin domain containing 3	Mus musculus	143-148
22327078-0	2012	Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin.	Nigericin	109-118	NLR family, pyrin domain containing 3	Mus musculus	9-14
22882971-2	2012	Several reports have demonstrated that crystalline, but also non-crystalline silica particles induce IL-1beta release from macrophages via the NALP3-inflammasome complex (caspase-1, ASC and NALP3) in the presence of lipopolysaccharide (LPS) from bacteria.	Silicon Dioxide	77-83	NLR family, pyrin domain containing 3	Mus musculus	190-195
22700321-0	2012	Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance.	Fatty Acids	8-29	NLR family, pyrin domain containing 3	Mus musculus	40-45
22700321-2	2012	We hypothesized that saturated fatty acids (SFA) directly prime the NLRP3 inflammasome via TLR4 concurrent with IR.	Fatty Acids	21-42	NLR family, pyrin domain containing 3	Mus musculus	68-73
22700321-2	2012	We hypothesized that saturated fatty acids (SFA) directly prime the NLRP3 inflammasome via TLR4 concurrent with IR.	Fatty Acids	44-47	NLR family, pyrin domain containing 3	Mus musculus	68-73
22383490-2	2012	The purinergic receptor P2X7 is upstream of the nod-like receptor family, pryin domain containing-3 (NLRP3) inflammasome in immune cells and is activated by ATP and NAD that serve as damage-associated molecular patterns.	Adenosine Triphosphate	157-160	NLR family, pyrin domain containing 3	Mus musculus	101-106
22383490-2	2012	The purinergic receptor P2X7 is upstream of the nod-like receptor family, pryin domain containing-3 (NLRP3) inflammasome in immune cells and is activated by ATP and NAD that serve as damage-associated molecular patterns.	NAD	165-168	NLR family, pyrin domain containing 3	Mus musculus	101-106
22453828-2	2012	Here we show that phagocytosis of ultrahigh molecular weight polyethylene particles induces damage to the endosomal-limiting membrane and results in the leakage of cathepsins into the cytosol and NLRP3-inflammasome activation.	Polyethylene	61-73	NLR family, pyrin domain containing 3	Mus musculus	196-201
22453828-5	2012	Finally, an increase in cytosolic cathepsins, NLRP3-inflammasome activation, and IL-1 production is seen in dendritic cells from annexin A2-null mice, following exposure to polyethylene particles.	Polyethylene	173-185	NLR family, pyrin domain containing 3	Mus musculus	46-51
22647887-4	2012	Treatment of podocytes with l-homocysteine induced the formation of NALP3 inflammasome complex, an increase in caspase 1 activity, podocyte cytoskeleton rearrangement, and decreased production of vascular endothelial growth factor from podocytes, which were all blocked by silencing the ASC gene or inhibiting caspase 1 activity.	Homocysteine	28-42	NLR family, pyrin domain containing 3	Mus musculus	68-73
22647887-5	2012	In mice with hHcys induced by feeding them a folate-free diet, NALP3 inflammasome formation and activation in glomerular podocytes were detected at an early stage, as shown by confocal microscopy, size exclusion chromatography of the assembled inflammasome complex, and increased interleukin-1beta production in glomeruli.	Folic Acid	45-51	NLR family, pyrin domain containing 3	Mus musculus	63-68
22647887-8	2012	In conclusion, NALP3 inflammasome formation and activation on stimulation of homocysteine are important molecular mechanisms triggering podocyte injury and ultimately resulting in glomerulosclerosis in hHcys.	Homocysteine	77-89	NLR family, pyrin domain containing 3	Mus musculus	15-20
22327078-5	2012	Our study demonstrates for the first time, to our knowledge, that during influenza viral infection, elderly mice have impaired NLRP3 inflammasome activity and that treatment with nigericin rescues NLRP3 activation in elderly hosts.	Nigericin	179-188	NLR family, pyrin domain containing 3	Mus musculus	127-132
22246178-10	2012	Finally, we provide further insights by demonstrating that statins enhance NLRP3-inflammasome activation by increasing mitochondrial reactive oxygen species generation in macrophages.	Reactive Oxygen Species	133-156	NLR family, pyrin domain containing 3	Mus musculus	75-80
22246178-11	2012	CONCLUSIONS: Statin use is associated with ILA among smokers in the COPDGene study and enhances bleomycin-induced lung inflammation and fibrosis in the mouse through a mechanism involving enhanced NLRP3-inflammasome activation.	Bleomycin	96-105	NLR family, pyrin domain containing 3	Mus musculus	197-202
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Adenosine Triphosphate	112-115	NLR family, pyrin domain containing 3	Mus musculus	146-151
22207130-0	2012	IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1beta by keratinocytes via the ROS-NLRP3-caspase-1 pathway.	Reactive Oxygen Species	108-111	NLR family, pyrin domain containing 3	Mus musculus	112-117
22207130-5	2012	RESULTS: We found that treatment with IL-17 and IL-22 causes an increase in IL-1beta via the activation of NLRP3 by a process that involves the generation of reactive oxygen species.	Reactive Oxygen Species	158-181	NLR family, pyrin domain containing 3	Mus musculus	107-112
21952942-0	2012	NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4)  in a murine model of gout.	Leukotriene B4	82-95	NLR family, pyrin domain containing 3	Mus musculus	0-5
21952942-11	2012	Mechanistically, LTB(4)  drove MSU crystal-induced production of ROS and ROS-dependent activation of the NLRP3 inflammasome.	Reactive Oxygen Species	73-76	NLR family, pyrin domain containing 3	Mus musculus	105-110
22147847-3	2012	Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid, activating the NLRP3 inflammasome complex and cleaving pro-IL-1beta to mature IL-1beta through caspase-1.	Uric Acid	120-129	NLR family, pyrin domain containing 3	Mus musculus	146-151
23075874-3	2012	Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages activates the Nlrp3 inflammasome and that Nlrp3(-/-) mice are protected in the acute DSS colitis model.	dextran sodium sulfate	43-65	NLR family, pyrin domain containing 3	Mus musculus	101-106
23075874-3	2012	Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages activates the Nlrp3 inflammasome and that Nlrp3(-/-) mice are protected in the acute DSS colitis model.	dss	67-70	NLR family, pyrin domain containing 3	Mus musculus	101-106
23075874-3	2012	Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages activates the Nlrp3 inflammasome and that Nlrp3(-/-) mice are protected in the acute DSS colitis model.	dss	172-175	NLR family, pyrin domain containing 3	Mus musculus	129-134
23075874-4	2012	Of note, other groups have reported opposing effects in regards to DSS susceptibility in Nlrp3(-/-) mice.	dss	67-70	NLR family, pyrin domain containing 3	Mus musculus	89-94
23075874-8	2012	RESULTS: Nlrp3(-/-) mice treated with either DSS or TNBS exhibited attenuated colitis and lower mortality.	dss	45-48	NLR family, pyrin domain containing 3	Mus musculus	9-14
23075874-8	2012	RESULTS: Nlrp3(-/-) mice treated with either DSS or TNBS exhibited attenuated colitis and lower mortality.	Trinitrobenzenesulfonic Acid	52-56	NLR family, pyrin domain containing 3	Mus musculus	9-14
21792841-11	2011	Furthermore, NLRP3(-/-)  mice and ASC(-/-)  mice were resistant to bleomycin-induced skin fibrosis, which suggests a key role for the inflammasome in in vivo fibrosis.	Bleomycin	67-76	NLR family, pyrin domain containing 3	Mus musculus	13-18
23271661-3	2012	Here we show that increased extracellular calcium activates the NLRP3 inflammasome via stimulation of G protein-coupled calcium sensing receptors.	Calcium	42-49	NLR family, pyrin domain containing 3	Mus musculus	64-69
22768222-5	2012	We show that activation of NALP3 depends on phagocytosis of dying cells, ATP release through pannexin-1 channels of dying autophagic cells, P(2)X(7) purinergic receptor activation, and on consequent potassium efflux.	Adenosine Triphosphate	73-76	NLR family, pyrin domain containing 3	Mus musculus	27-32
22768222-5	2012	We show that activation of NALP3 depends on phagocytosis of dying cells, ATP release through pannexin-1 channels of dying autophagic cells, P(2)X(7) purinergic receptor activation, and on consequent potassium efflux.	Potassium	199-208	NLR family, pyrin domain containing 3	Mus musculus	27-32
22606244-1	2012	Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium.	Potassium	102-111	NLR family, pyrin domain containing 3	Mus musculus	52-57
22606244-9	2012	Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome.	Potassium	123-132	NLR family, pyrin domain containing 3	Mus musculus	162-167
21862582-10	2011	Thus, the deacetylated polysaccharide chitosan potently activates the NLRP3 inflammasome in a phagocytosis-dependent manner.	Polysaccharides	23-37	NLR family, pyrin domain containing 3	Mus musculus	70-75
21862582-10	2011	Thus, the deacetylated polysaccharide chitosan potently activates the NLRP3 inflammasome in a phagocytosis-dependent manner.	Chitosan	38-46	NLR family, pyrin domain containing 3	Mus musculus	70-75
21641991-0	2011	Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation.	epigallocatechin gallate	0-26	NLR family, pyrin domain containing 3	Mus musculus	130-135
21856950-0	2011	NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy.	Durapatite	64-78	NLR family, pyrin domain containing 3	Mus musculus	0-5
21641991-5	2011	Our data clearly demonstrate that EGCG has prophylactic effects on lupus nephritis in these mice that are highly associated with its effects of enhancing the Nrf2 antioxidant signaling pathway, decreasing renal NLRP3 inflammasome activation, and increasing systemic Treg cell activity.	epigallocatechin gallate	34-38	NLR family, pyrin domain containing 3	Mus musculus	211-216
21464611-0	2011	Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome.	Doxorubicin	0-11	NLR family, pyrin domain containing 3	Mus musculus	106-111
21484785-4	2011	We show that cholesterol crystals, which accumulate in atherosclerotic plaques, represent an endogenous danger signal that activates Nrf2 and the NLRP3 inflammasome.	Cholesterol	13-24	NLR family, pyrin domain containing 3	Mus musculus	146-151
21484785-7	2011	Our studies demonstrate a role for Nrf2 in inflammasome activation, and identify cholesterol crystals as disease-relevant triggers of the NLRP3 inflammasome and potent pro-atherogenic cytokine responses.	Cholesterol	81-92	NLR family, pyrin domain containing 3	Mus musculus	138-143
21464611-0	2011	Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome.	Daunorubicin	16-28	NLR family, pyrin domain containing 3	Mus musculus	106-111
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Doxorubicin	97-108	NLR family, pyrin domain containing 3	Mus musculus	71-76
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Doxorubicin	97-108	NLR family, pyrin domain containing 3	Mus musculus	166-171
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Daunorubicin	113-125	NLR family, pyrin domain containing 3	Mus musculus	71-76
21464611-10	2011	The release of IL-1beta required the expression of ASC, caspase-1, and NLRP3, demonstrating that doxorubicin and daunorubicin-induced inflammation is mediated by the NLRP3 inflammasome.	Daunorubicin	113-125	NLR family, pyrin domain containing 3	Mus musculus	166-171
21464611-11	2011	As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium.	Doxorubicin	86-97	NLR family, pyrin domain containing 3	Mus musculus	51-56
21464611-11	2011	As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium.	ros	184-187	NLR family, pyrin domain containing 3	Mus musculus	51-56
21464611-11	2011	As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium.	Potassium	244-253	NLR family, pyrin domain containing 3	Mus musculus	51-56
21278344-0	2011	Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1beta secretion by activating the NLRP3 inflammasome.	aminoglycoside antibiotics	37-63	NLR family, pyrin domain containing 3	Mus musculus	109-114
21396389-0	2011	Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.	Acetaminophen	34-47	NLR family, pyrin domain containing 3	Mus musculus	12-17
21396389-4	2011	The objective of this invetstigation was to evaluate the role of the Nalp3 inflammasome on release of damage associated molecular patterns (DAMPs), hepatic neutrophil accumulation and liver injury (ALT, necrosis) after APAP overdose.	Acetaminophen	219-223	NLR family, pyrin domain containing 3	Mus musculus	69-74
21396389-7	2011	In addition, aspirin treatment, which has been postulated to attenuate cytokine formation and the activation of the Nalp3 inflammasome after APAP, had no effect on release of DAMPs, hepatic neutrophil accumulation or liver injury.	Aspirin	13-20	NLR family, pyrin domain containing 3	Mus musculus	116-121
21396389-7	2011	In addition, aspirin treatment, which has been postulated to attenuate cytokine formation and the activation of the Nalp3 inflammasome after APAP, had no effect on release of DAMPs, hepatic neutrophil accumulation or liver injury.	Acetaminophen	141-145	NLR family, pyrin domain containing 3	Mus musculus	116-121
21497116-0	2011	Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.	Silicon Dioxide	0-6	NLR family, pyrin domain containing 3	Mus musculus	95-100
21497116-0	2011	Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.	aluminum salts	20-34	NLR family, pyrin domain containing 3	Mus musculus	95-100
21497116-0	2011	Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.	Prostaglandins	62-75	NLR family, pyrin domain containing 3	Mus musculus	95-100
21217695-4	2011	We further found that the Nlrp3 inflammasome senses lipotoxicity-associated increases in intracellular ceramide to induce caspase-1 cleavage in macrophages and adipose tissue.	Ceramides	103-111	NLR family, pyrin domain containing 3	Mus musculus	26-31
21625424-5	2011	All three drugs induced potassium efflux from the cells as a known mechanism for NLRP3 activation but the P2X7 receptor was not required for this process.	Potassium	24-33	NLR family, pyrin domain containing 3	Mus musculus	81-86
22216309-7	2011	Confocal microscopy and Western blotting assays indicated that CRID3 inhibited the formation of ASC complexes or "specks" in response to NLRP3 and AIM2 stimulation.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	63-68	NLR family, pyrin domain containing 3	Mus musculus	137-142
22216309-9	2011	SIGNIFICANCE: These results identify CRID3 as a novel inhibitor of the NLRP3 and AIM2 inflammasomes and provide an insight into the mechanism of action of this small molecule.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	37-42	NLR family, pyrin domain containing 3	Mus musculus	71-76
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	polyene macrolides	14-32	NLR family, pyrin domain containing 3	Mus musculus	153-158
21625424-0	2011	Polyene macrolide antifungal drugs trigger interleukin-1beta secretion by activating the NLRP3 inflammasome.	polyene macrolide	0-17	NLR family, pyrin domain containing 3	Mus musculus	89-94
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Amphotericin B	33-47	NLR family, pyrin domain containing 3	Mus musculus	153-158
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Nystatin	49-57	NLR family, pyrin domain containing 3	Mus musculus	153-158
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Natamycin	63-72	NLR family, pyrin domain containing 3	Mus musculus	153-158
21625424-7	2011	Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1.	Potassium	111-120	NLR family, pyrin domain containing 3	Mus musculus	153-158
21106820-4	2010	This work shows that expression of the Nlrp3 gene was increased &gt;100-fold in a cuprizone-induced demyelination and neuroinflammation model.	Cuprizone	82-91	NLR family, pyrin domain containing 3	Mus musculus	39-44
21048113-0	2010	Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production.	Reactive Oxygen Species	93-116	NLR family, pyrin domain containing 3	Mus musculus	49-54
21048113-4	2010	After stimulation with ATP, an agonist of the NLRP3 inflammasome, knockdown of TRIM30 enhanced caspase-1 activation and increased production of IL-1beta in both J774 cells and bone marrow-derived macrophages.	Adenosine Triphosphate	23-26	NLR family, pyrin domain containing 3	Mus musculus	46-51
21048113-6	2010	Production of reactive oxygen species was increased in TRIM30 knockdown cells, and its increase was required for enhanced NLRP3 inflammasome activation, because antioxidant treatment blocked excess IL-1beta production.	Reactive Oxygen Species	14-37	NLR family, pyrin domain containing 3	Mus musculus	122-127
21048113-8	2010	Finally, in a crystal-induced NLRP3 inflammasome-dependent peritonitis model, monosodium urate-induced neutrophil flux and IL-1beta production was reduced significantly in TRIM30 transgenic mice as compared with that in their nontransgenic littermates.	Uric Acid	78-94	NLR family, pyrin domain containing 3	Mus musculus	30-35
20428172-0	2010	NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.	Cholesterol	68-79	NLR family, pyrin domain containing 3	Mus musculus	0-5
20855874-5	2010	In this study, we showed that mice deficient for Nlrp3 or the inflammasome effector caspase-1 were highly susceptible to azoxymethane/dextran sodium sulfate-induced inflammation and suffered from dramatically increased tumor burdens in the colon.	Azoxymethane	121-133	NLR family, pyrin domain containing 3	Mus musculus	49-54
20855874-5	2010	In this study, we showed that mice deficient for Nlrp3 or the inflammasome effector caspase-1 were highly susceptible to azoxymethane/dextran sodium sulfate-induced inflammation and suffered from dramatically increased tumor burdens in the colon.	dextran sodium sulfate	134-156	NLR family, pyrin domain containing 3	Mus musculus	49-54
20522787-2	2010	We previously investigated the endogenous mediators released on lung injury and showed that uric acid is a danger signal activating Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in lung inflammation and fibrosis (Gasse et al., Am J Respir Crit Care Med 2009;179:903-913).	Uric Acid	92-101	NLR family, pyrin domain containing 3	Mus musculus	185-190
20442201-0	2010	Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.	Dextran Sulfate	29-51	NLR family, pyrin domain containing 3	Mus musculus	77-82
20442201-0	2010	Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.	Dextran Sulfate	53-56	NLR family, pyrin domain containing 3	Mus musculus	77-82
20442201-3	2010	Here, the role of the NLRP3 inflammasome in experimental colitis induced by dextran sodium sulfate (DSS) was examined.	dextran sodium sulfate	76-98	NLR family, pyrin domain containing 3	Mus musculus	22-27
20442201-3	2010	Here, the role of the NLRP3 inflammasome in experimental colitis induced by dextran sodium sulfate (DSS) was examined.	Dextran Sulfate	100-103	NLR family, pyrin domain containing 3	Mus musculus	22-27
20442201-9	2010	IL-1beta secretion was abrogated in macrophages lacking NLRP3, ASC or caspase-1, indicating that DSS activates caspase-1 via the NLRP3 inflammasome.	Dextran Sulfate	97-100	NLR family, pyrin domain containing 3	Mus musculus	129-134
20442201-11	2010	After oral administration of DSS, NLRP3(-/-) mice developed a less severe colitis than wild-type mice and produced lower levels of proinflammatory cytokines in colonic tissue.	Dextran Sulfate	29-32	NLR family, pyrin domain containing 3	Mus musculus	34-39
20442201-13	2010	CONCLUSIONS: The NLRP3 inflammasome was identified as a critical mechanism of intestinal inflammation in the DSS colitis model.	Dextran Sulfate	109-112	NLR family, pyrin domain containing 3	Mus musculus	17-22
20576854-7	2010	Studies in Rag1(-/-) mice suggest further that lymphocytes may participate in the regulation of SiO(2)-induced inflammation through modulation of the Nalp3 inflammasome.	Silicon Dioxide	96-102	NLR family, pyrin domain containing 3	Mus musculus	150-155
20506351-0	2010	Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.	Uric Acid	61-77	NLR family, pyrin domain containing 3	Mus musculus	42-51
20506351-0	2010	Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.	Uric Acid	61-77	NLR family, pyrin domain containing 3	Mus musculus	52-57
20506351-1	2010	OBJECTIVE: The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown.	Uric Acid	34-62	NLR family, pyrin domain containing 3	Mus musculus	107-116
20506351-1	2010	OBJECTIVE: The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown.	Uric Acid	64-67	NLR family, pyrin domain containing 3	Mus musculus	107-116
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Reactive Oxygen Species	59-82	NLR family, pyrin domain containing 3	Mus musculus	190-195
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Reactive Oxygen Species	84-87	NLR family, pyrin domain containing 3	Mus musculus	190-195
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Reactive Oxygen Species	84-87	NLR family, pyrin domain containing 3	Mus musculus	196-205
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	99-116	NLR family, pyrin domain containing 3	Mus musculus	190-195
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	99-116	NLR family, pyrin domain containing 3	Mus musculus	196-205
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	118-121	NLR family, pyrin domain containing 3	Mus musculus	190-195
20862209-5	2010	Release of IL-1beta from macrophages was suppressed by the reactive oxygen species (ROS) scavenger N-acetyl cysteine (NAC) and high extracellular K(+), which are two agents known to inhibit NALP3/cryopyrin/CIAS1 inflammasome formation.	Acetylcysteine	118-121	NLR family, pyrin domain containing 3	Mus musculus	196-205
20428172-6	2010	Here we show that cholesterol crystals activate the NLRP3 inflammasome in phagocytes in vitro in a process that involves phagolysosomal damage.	Cholesterol	18-29	NLR family, pyrin domain containing 3	Mus musculus	52-57
20428172-7	2010	Similarly, when injected intraperitoneally, cholesterol crystals induce acute inflammation, which is impaired in mice deficient in components of the NLRP3 inflammasome, cathepsin B, cathepsin L or IL-1 molecules.	Cholesterol	44-55	NLR family, pyrin domain containing 3	Mus musculus	149-154
20428172-10	2010	Although there is the possibility that oxidized LDL activates the NLRP3 inflammasome in vivo, our results demonstrate that crystalline cholesterol acts as an endogenous danger signal and its deposition in arteries or elsewhere is an early cause rather than a late consequence of inflammation.	Cholesterol	135-146	NLR family, pyrin domain containing 3	Mus musculus	66-71
20303296-4	2010	Here, we showed that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis.	dextran sodium sulfate	94-116	NLR family, pyrin domain containing 3	Mus musculus	40-45
20303296-4	2010	Here, we showed that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	NLR family, pyrin domain containing 3	Mus musculus	40-45
20023662-4	2010	Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3.	Uric Acid	32-41	NLR family, pyrin domain containing 3	Mus musculus	177-182
20023662-4	2010	Inflammasome activators such as uric acid crystals induced the dissociation of TXNIP from thioredoxin in a reactive oxygen species (ROS)-sensitive manner and allowed it to bind NLRP3.	Reactive Oxygen Species	132-135	NLR family, pyrin domain containing 3	Mus musculus	177-182
19767732-2	2009	Here we show that dying tumor cells release ATP, which then acts on P2X(7) purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ("inflammasome"), allowing for the secretion of interleukin-1beta (IL-1beta).	Adenosine Triphosphate	44-47	NLR family, pyrin domain containing 3	Mus musculus	183-188
19675207-0	2009	Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner.	Cholesterol	0-11	NLR family, pyrin domain containing 3	Mus musculus	102-107
20007584-6	2009	Finally, IL-1beta production and inflammation are reduced in mice deficient for the NALP3 inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and we identified uric acid, which is produced upon elastase-induced lung injury, as an activator of the NALP3/ASC inflammasome.	Uric Acid	218-227	NLR family, pyrin domain containing 3	Mus musculus	84-89
19783673-0	2009	Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.	Uric Acid	90-99	NLR family, pyrin domain containing 3	Mus musculus	56-61
19783673-10	2009	These data suggest that uric acid is released during malaria infection and may serve to augment the initial host response to hemozoin via activation of the NALP3 inflammasome.	Uric Acid	24-33	NLR family, pyrin domain containing 3	Mus musculus	156-161
19359429-12	2009	Mice lacking the inflammasome-sensing and adaptor molecules, NLRP3 and apoptosis-associated speck-like protein containing CARD, had reduced CCl(4) and TAA-induced liver fibrosis.	Cefaclor	140-143	NLR family, pyrin domain containing 3	Mus musculus	61-66
19258328-0	2009	NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.	Hyaluronic Acid	85-95	NLR family, pyrin domain containing 3	Mus musculus	0-5
19218193-3	2009	OBJECTIVES: To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating the NALP3 inflammasome in the lung.	Bleomycin	92-95	NLR family, pyrin domain containing 3	Mus musculus	180-185
19218193-3	2009	OBJECTIVES: To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating the NALP3 inflammasome in the lung.	Uric Acid	146-155	NLR family, pyrin domain containing 3	Mus musculus	180-185
19218193-6	2009	MEASUREMENTS AND MAIN RESULTS: Lung injury depends on the NALP3 inflammasome, which is triggered by uric acid locally produced in the lung upon BLM-induced DNA damage and degradation.	Uric Acid	100-109	NLR family, pyrin domain containing 3	Mus musculus	58-63
19218193-8	2009	Local administration of exogenous uric acid crystals recapitulates lung inflammation and repair, which depend on the NALP3 inflammasome, MyD88, and IL-1R1 pathways and Toll-like receptor (TLR)2 and TLR4 for optimal inflammation but are independent of the IL-18 receptor.	Uric Acid	34-43	NLR family, pyrin domain containing 3	Mus musculus	117-122
19218193-9	2009	CONCLUSIONS: Uric acid released from injured cells constitutes a major endogenous danger signal that activates the NALP3 inflammasome, leading to IL-1beta production.	Uric Acid	13-22	NLR family, pyrin domain containing 3	Mus musculus	115-120
19218193-0	2009	Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.	Uric Acid	0-9	NLR family, pyrin domain containing 3	Mus musculus	40-45
19218193-3	2009	OBJECTIVES: To determine if lung injury depends on the NALP3 inflammasome and if bleomycin (BLM)-induced lung injury triggers local production of uric acid, thereby activating the NALP3 inflammasome in the lung.	Bleomycin	81-90	NLR family, pyrin domain containing 3	Mus musculus	180-185
19428913-2	2009	It has recently been shown that one member of an intracellular PRR, the NLRP3 inflammasome, is activated by a number of classical adjuvants including aluminum hydroxide and saponins [Eisenbarth SC, Colegio OR, O"Connor W, Sutterwala FS, Flavell RA.	Aluminum Hydroxide	150-168	NLR family, pyrin domain containing 3	Mus musculus	72-77
19428913-2	2009	It has recently been shown that one member of an intracellular PRR, the NLRP3 inflammasome, is activated by a number of classical adjuvants including aluminum hydroxide and saponins [Eisenbarth SC, Colegio OR, O"Connor W, Sutterwala FS, Flavell RA.	Saponins	173-181	NLR family, pyrin domain containing 3	Mus musculus	72-77
19428913-3	2009	Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.	Aluminum	79-88	NLR family, pyrin domain containing 3	Mus musculus	21-26
19428913-13	2009	Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.	Silicon Dioxide	0-6	NLR family, pyrin domain containing 3	Mus musculus	48-53
19428913-13	2009	Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.	aluminum salts	20-34	NLR family, pyrin domain containing 3	Mus musculus	48-53
19258328-0	2009	NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury.	Hyaluronic Acid	85-95	NLR family, pyrin domain containing 3	Mus musculus	6-15
19258328-5	2009	Similarly, the addition of hyaluronan to macrophages derived from cryopyrin-deficient mice increased release of Cxcl2 but did not increase IL-1beta release.	Hyaluronic Acid	27-37	NLR family, pyrin domain containing 3	Mus musculus	66-75
19258328-6	2009	To define the mechanism of hyaluronan-mediated activation of cryopyrin, elements of the hyaluronan recognition process were studied in detail.	Hyaluronic Acid	27-37	NLR family, pyrin domain containing 3	Mus musculus	61-70
19258328-6	2009	To define the mechanism of hyaluronan-mediated activation of cryopyrin, elements of the hyaluronan recognition process were studied in detail.	Hyaluronic Acid	88-98	NLR family, pyrin domain containing 3	Mus musculus	61-70
19258328-9	2009	Therefore, the action of CD44 and subsequent hyaluronan catabolism trigger the intracellular cryopyrin --&gt; IL-1beta pathway.	Hyaluronic Acid	45-55	NLR family, pyrin domain containing 3	Mus musculus	93-102
19258328-10	2009	These findings support the hypothesis that hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation.	Hyaluronic Acid	43-53	NLR family, pyrin domain containing 3	Mus musculus	85-94
19120479-6	2009	Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of microbial components and in response to crystalline substances such as the endogenous danger signal uric acid.	Uric Acid	179-188	NLR family, pyrin domain containing 3	Mus musculus	0-9
19164858-0	2009	Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.	Acetaminophen	0-13	NLR family, pyrin domain containing 3	Mus musculus	74-79
19164858-6	2009	By activating caspase-1, the enzyme responsible for generating mature IL-1beta and IL-18 from pro-IL-1beta and pro-IL-18, respectively, the Nalp3 inflammasome plays a crucial role in the second step of proinflammatory cytokine activation following acetaminophen-induced liver injury.	Acetaminophen	248-261	NLR family, pyrin domain containing 3	Mus musculus	140-145
19164858-9	2009	In summary, we have identified a 2-signal requirement (Tlr9 and the Nalp3 inflammasome) for acetaminophen-induced hepatotoxicity and some potential therapeutic approaches.	Acetaminophen	92-105	NLR family, pyrin domain containing 3	Mus musculus	68-73
19120479-6	2009	Cryopyrin/NALP3 mediates caspase-1 activation in response to a wide variety of microbial components and in response to crystalline substances such as the endogenous danger signal uric acid.	Uric Acid	179-188	NLR family, pyrin domain containing 3	Mus musculus	10-15
16407889-0	2006	Gout-associated uric acid crystals activate the NALP3 inflammasome.	Uric Acid	16-25	NLR family, pyrin domain containing 3	Mus musculus	48-53
18768827-2	2008	In this study we show that alum adjuvant induces the release of IL-1beta from macrophages and dendritic cells and that this is abrogated in cells lacking various NALP3 inflammasome components.	alum adjuvant	27-40	NLR family, pyrin domain containing 3	Mus musculus	162-167
18656551-2	2008	Here we report that NLRP3 acts as a novel negative regulator of delayed prostaglandin (PG) D(2) production in BMMCs.	Prostaglandin D2	72-95	NLR family, pyrin domain containing 3	Mus musculus	20-25
18656551-4	2008	Ectopic expression of NLRP3 in BMMCs resulted in marked attenuation of cyclooxygenase (COX)-2-dependent delayed PGD(2) generation, whereas it had no effects on other effector functions, including degranulation, COX-1-dependent immediate PGD(2) generation and cytokine/chemokine expression.	Prostaglandins D	112-115	NLR family, pyrin domain containing 3	Mus musculus	22-27
18656551-4	2008	Ectopic expression of NLRP3 in BMMCs resulted in marked attenuation of cyclooxygenase (COX)-2-dependent delayed PGD(2) generation, whereas it had no effects on other effector functions, including degranulation, COX-1-dependent immediate PGD(2) generation and cytokine/chemokine expression.	Prostaglandins D	237-240	NLR family, pyrin domain containing 3	Mus musculus	22-27
18656551-6	2008	Moreover, in CTMC-like differentiated cells in which endogenous NLRP3 expression was induced, cytokine-stimulated induction of COX-2 and attendant delayed PGD(2) generation were markedly reduced.	ctmc	13-17	NLR family, pyrin domain containing 3	Mus musculus	64-69
18656551-7	2008	Our results suggest that, in mouse mast cells, NLRP3 counter-regulates COX-2-dependent sustained production of PGD(2), a prostanoid that exhibits both pro- and anti-allergic effects, thereby potentially influencing the duration of allergic and other mast cell-associated inflammatory diseases.	Prostaglandin D2	111-117	NLR family, pyrin domain containing 3	Mus musculus	47-52
18656551-7	2008	Our results suggest that, in mouse mast cells, NLRP3 counter-regulates COX-2-dependent sustained production of PGD(2), a prostanoid that exhibits both pro- and anti-allergic effects, thereby potentially influencing the duration of allergic and other mast cell-associated inflammatory diseases.	Prostaglandins	121-131	NLR family, pyrin domain containing 3	Mus musculus	47-52
18768827-0	2008	Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome.	alum adjuvant	14-27	NLR family, pyrin domain containing 3	Mus musculus	94-99
18403674-0	2008	Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.	Silicon Dioxide	76-82	NLR family, pyrin domain containing 3	Mus musculus	33-38
18403674-3	2008	Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion.	Silicon Dioxide	32-38	NLR family, pyrin domain containing 3	Mus musculus	57-62
14688236-5	2003	MMIG-1 was distributed in the cytosol of CTMC-like differentiated BMMC.	ctmc	41-45	NLR family, pyrin domain containing 3	Mus musculus	0-6
16546100-4	2006	NALP3 was essential for the ATP-driven activation of caspase-1 in lipopolysaccharide-stimulated macrophages and for the efficient secretion of the caspase-1-dependent cytokines IL-1alpha, IL-1beta, and IL-18.	Adenosine Triphosphate	28-31	NLR family, pyrin domain containing 3	Mus musculus	0-5
33770730-0	2021	Oridonin ameliorates noise-induced hearing loss by blocking NLRP3 - NEK7 mediated inflammasome activation.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	60-65
33773468-0	2021	4-Acetylantroquinonol B ameliorates nonalcoholic steatohepatitis by suppression of ER stress and NLRP3 inflammasome activation.	4-acetylantroquinonol B	0-23	NLR family, pyrin domain containing 3	Mus musculus	97-102
33770730-5	2021	These results indicate that the activation of inflammasomes in the cochleae of mice during the pathological process of NIHL as well as NLRP3, a sensor protein of reactive oxygen species (ROS), may be key factors for inflammasome assembly and subsequent inflammation in cochleae.	Reactive Oxygen Species	162-185	NLR family, pyrin domain containing 3	Mus musculus	135-140
33773468-10	2021	In addition, 4-AAQB suppressed inflammatory responses, ER stress, and NLRP3 inflammasome activation, but increased the nuclear factor erythroid 2-related factor 2 (Nrf2) and Sirtuin 1 (SIRT1) signaling pathways in both in vitro and in vivo models.	4-acetylantroquinonol B	13-19	NLR family, pyrin domain containing 3	Mus musculus	70-75
33770730-5	2021	These results indicate that the activation of inflammasomes in the cochleae of mice during the pathological process of NIHL as well as NLRP3, a sensor protein of reactive oxygen species (ROS), may be key factors for inflammasome assembly and subsequent inflammation in cochleae.	Reactive Oxygen Species	187-190	NLR family, pyrin domain containing 3	Mus musculus	135-140
33770730-6	2021	Moreover, many recent studies have revealed that NEK7 is an important component and regulator of NLRP3 inflammasomes by interacting with NLRP3 directly and that these interactions can be interrupted by oridonin.	oridonin	202-210	NLR family, pyrin domain containing 3	Mus musculus	97-102
33770730-6	2021	Moreover, many recent studies have revealed that NEK7 is an important component and regulator of NLRP3 inflammasomes by interacting with NLRP3 directly and that these interactions can be interrupted by oridonin.	oridonin	202-210	NLR family, pyrin domain containing 3	Mus musculus	137-142
33770730-7	2021	Here, we further determined that treatment with oridonin could indeed interrupt the interaction between NLRP3 and NEK7 as well as inhibit the downstream inflammasome activation in mouse cochleae after noise exposure.	oridonin	48-56	NLR family, pyrin domain containing 3	Mus musculus	104-109
33812251-0	2021	Potential of Forsythoside I as a therapeutic approach for acute lung injury: Involvement of TXNIP/NLRP3 inflammasome.	isoforsythiaside	13-27	NLR family, pyrin domain containing 3	Mus musculus	98-103
33972740-5	2021	Mechanistically, RRx-001 covalently binds to cysteine 409 of NLRP3 via its bromoacetyl group and therefore blocks the NLRP3-NEK7 interaction, which is critical for the assembly and activation of the NLRP3 inflammasome.	Cysteine	45-53	NLR family, pyrin domain containing 3	Mus musculus	61-66
33941658-5	2021	The combined injection of sterile cecal content (SCC) and the gut commensal bacteria Bacteroides fragilis leads to IL-1beta-dependent peritonitis, which was mitigated in mice deficient in NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome components.	Leucine	222-229	NLR family, pyrin domain containing 3	Mus musculus	188-193
33794337-0	2021	17beta-estradiol reduces demyelination in cuprizone-fed mice by promoting M2 microglia polarity and regulating NLRP3 inflammasome.	Estradiol	0-16	NLR family, pyrin domain containing 3	Mus musculus	111-116
33794337-0	2021	17beta-estradiol reduces demyelination in cuprizone-fed mice by promoting M2 microglia polarity and regulating NLRP3 inflammasome.	Cuprizone	42-51	NLR family, pyrin domain containing 3	Mus musculus	111-116
33794337-7	2021	Moreover, administration of 17beta-estradiol resulted in a significant reduction (~3-fold) in transcript levels of NLRP3 inflammasome and its downstream product IL-18, comapred to controls.	Estradiol	28-44	NLR family, pyrin domain containing 3	Mus musculus	115-120
33794337-8	2021	In summary, this study demonstrated for the first time that exogenous 17beta-estradiol therapy robustly leads to the reduction of M1 phenotype, stimulation of polarized M2 microglia, and repression of NLRP3 inflammasome in the corpus callosum of CPZ demyelination model of MS.	Estradiol	70-86	NLR family, pyrin domain containing 3	Mus musculus	201-206
33823244-13	2021	We also observed that kaempferol could inhibite the pyroptosis related proteins (NLRP3 Caspase-1 p10 ASC N-GSDMD) and reduce the release of IL-18 and IL-1beta.	kaempferol	22-32	NLR family, pyrin domain containing 3	Mus musculus	81-86
33775855-5	2021	Our data showed that walnut oil ameliorated the pathological morphology, decreased the reactive oxygen species (ROS) production and pro-inflammatory cytokines release, down-regulated the related gene proteins expression of NLRP3/ASC/Caspase-1 inflammatory pathway, inhibited apoptosis, shifted from more pathogenic bacteria towards probiotics, and increased the levels of short-chain fatty acids (SCFAs) in DSS-induced damaging process.	Fatty Acids, Volatile	372-395	NLR family, pyrin domain containing 3	Mus musculus	223-228
33775855-0	2021	Walnut oil alleviates DSS-induced colitis in mice by inhibiting NLRP3 inflammasome activation and regulating gut microbiota.	walnut oil	0-10	NLR family, pyrin domain containing 3	Mus musculus	64-69
33775855-0	2021	Walnut oil alleviates DSS-induced colitis in mice by inhibiting NLRP3 inflammasome activation and regulating gut microbiota.	Dextran Sulfate	22-25	NLR family, pyrin domain containing 3	Mus musculus	64-69
33775855-2	2021	Furthermore, the NLRP3 inflammasome activation is a key cause in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	85-107	NLR family, pyrin domain containing 3	Mus musculus	17-22
33775855-2	2021	Furthermore, the NLRP3 inflammasome activation is a key cause in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.	Dextran Sulfate	109-112	NLR family, pyrin domain containing 3	Mus musculus	17-22
33775855-4	2021	Therefore, we investigated whether walnut oil exerts an anti-inflammatory effect on DSS-induced colitis mice by targeting NLRP3 inflammasome and gut microbiota.	walnut oil	35-45	NLR family, pyrin domain containing 3	Mus musculus	122-127
33775855-5	2021	Our data showed that walnut oil ameliorated the pathological morphology, decreased the reactive oxygen species (ROS) production and pro-inflammatory cytokines release, down-regulated the related gene proteins expression of NLRP3/ASC/Caspase-1 inflammatory pathway, inhibited apoptosis, shifted from more pathogenic bacteria towards probiotics, and increased the levels of short-chain fatty acids (SCFAs) in DSS-induced damaging process.	walnut oil	21-31	NLR family, pyrin domain containing 3	Mus musculus	223-228
33939881-0	2021	Quercetin Attenuates Atherosclerotic Inflammation by Inhibiting Gal-3-NLRP3 Signaling Pathway.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
33939881-2	2021	Herein, we investigated the anti-arteriosclerotic properties of quercetin by modulating galectin-3 (Gal-3)-NLR family, pyrin domain-containing 3 (NLRP3) pathway.	Quercetin	64-73	NLR family, pyrin domain containing 3	Mus musculus	146-151
33939881-6	2021	Furthermore, immunofluorescence and immunohistochemistry exhibited higher expressions of Gal-3 and NLRP3 in carotid plaques and plaques from HFD-fed mice, which were concurrently downregulated by quercetin.	Quercetin	196-205	NLR family, pyrin domain containing 3	Mus musculus	99-104
33939881-7	2021	Similar to TD139, quercetin dramatically suppressed NLRP3 inflammasome activation in ox-LDL-laden macrophages, and accordingly alleviated cellular steatosis and IL-1beta secretion, which was abolished by recombinant Gal-3.	Quercetin	18-27	NLR family, pyrin domain containing 3	Mus musculus	52-57
33939881-9	2021	CONCLUSION: Gal-3 initiates inflammatory lesions by activating NLRP3 inflammasome which functions as a candidate target of quercetin exerting favorable anti-atherogenic effects.	Quercetin	123-132	NLR family, pyrin domain containing 3	Mus musculus	63-68
33775855-5	2021	Our data showed that walnut oil ameliorated the pathological morphology, decreased the reactive oxygen species (ROS) production and pro-inflammatory cytokines release, down-regulated the related gene proteins expression of NLRP3/ASC/Caspase-1 inflammatory pathway, inhibited apoptosis, shifted from more pathogenic bacteria towards probiotics, and increased the levels of short-chain fatty acids (SCFAs) in DSS-induced damaging process.	Fatty Acids, Volatile	397-402	NLR family, pyrin domain containing 3	Mus musculus	223-228
33775855-5	2021	Our data showed that walnut oil ameliorated the pathological morphology, decreased the reactive oxygen species (ROS) production and pro-inflammatory cytokines release, down-regulated the related gene proteins expression of NLRP3/ASC/Caspase-1 inflammatory pathway, inhibited apoptosis, shifted from more pathogenic bacteria towards probiotics, and increased the levels of short-chain fatty acids (SCFAs) in DSS-induced damaging process.	Dextran Sulfate	407-410	NLR family, pyrin domain containing 3	Mus musculus	223-228
33775855-6	2021	Collectively, our study concludes that walnut oil exerts anti-inflammatory effect on DSS-induced colitis in mice by inhibiting the NLRP3 inflammasome activation and modulating gut microbiota, and may be a prominent functional food candidate for UC treatment.	walnut oil	39-49	NLR family, pyrin domain containing 3	Mus musculus	131-136
33775855-6	2021	Collectively, our study concludes that walnut oil exerts anti-inflammatory effect on DSS-induced colitis in mice by inhibiting the NLRP3 inflammasome activation and modulating gut microbiota, and may be a prominent functional food candidate for UC treatment.	Dextran Sulfate	85-88	NLR family, pyrin domain containing 3	Mus musculus	131-136
33034415-15	2021	The results showed that when 3-MA and BafA1 were applied, the promotion of autophagy by zinc was blocked and that the inhibitory effect of zinc on NLRP3 was reversed.	3-methyladenine	29-33	NLR family, pyrin domain containing 3	Mus musculus	147-152
33801675-10	2021	For the first time, we showed that melatonin significantly reduced the expression of miR-21, miR-146a, and miR-223 (p < 0.05 for all ones, and p < 0.01 for miR-21 at 24 months old) in aged WT mice, increased miR-223 in NLRP3- mice (p < 0.05), and induced miR-483 expression in both mice strains, this increase being significant at 24 months of age.	Melatonin	35-44	NLR family, pyrin domain containing 3	Mus musculus	219-224
33587908-15	2021	Besides, in dry eye mouse model, intraperitoneal injection of melatonin showed greatly improved clinical parameters, inhibited activated NLRP3 inflammation cascade, and increased density of goblet cells and tear volume.	Melatonin	62-71	NLR family, pyrin domain containing 3	Mus musculus	137-142
33588680-8	2021	Furthermore, schizandrin could dramatically inhibit the neuroinflammation in mice by reducing pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) through regulating NF-kappaB/NLRP3/Iba-1 signaling.	schizandrin	13-24	NLR family, pyrin domain containing 3	Mus musculus	182-187
33788266-10	2021	Triptolide also down-regulated ubiquitin-proteasome molecules (n-FoxO3a/atrogin-1/MuRF1), proteasome activity, autophagy-lysosomal molecules (LC3-II/LC3-I and Bnip3), and inflammatory mediators (NF-kappaB, Cox-2, NLRP3, IL-1beta, and TNF-alpha).	triptolide	0-10	NLR family, pyrin domain containing 3	Mus musculus	213-218
33811893-0	2021	Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion acute kidney injury by inhibiting NLRP3 inflammasome.	Hydrogen Sulfide	0-16	NLR family, pyrin domain containing 3	Mus musculus	106-111
33811893-16	2021	H2S suppressed cell pyroptosis and kidney injury via inhibiting the NLRP3/Caspase-1 axis.	Deuterium	0-3	NLR family, pyrin domain containing 3	Mus musculus	68-73
33811893-17	2021	SIGNIFICANCE: We highlighted that H2S prevented cell pyroptosis via suppressing the NLRP3/Caspase-1 axis, thereby inhibiting I/R-induced AKI.	Deuterium	34-37	NLR family, pyrin domain containing 3	Mus musculus	84-89
32795894-9	2020	The protein levels of NLRP3 and cleaved caspase-1 were attenuated in the lung tissue following CHBP treatment.	chbp	95-99	NLR family, pyrin domain containing 3	Mus musculus	22-27
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	NLR family, pyrin domain containing 3	Mus musculus	251-256
33815373-5	2021	Blockages of EIII-neutrophil interaction using cell-binding competitive inhibitor or selective Nlrp3 inflammasome inhibitors OLT1177 and Z-WHED-FMK can suppress EIII-induced NETosis response.	z-whed-fmk	137-147	NLR family, pyrin domain containing 3	Mus musculus	95-100
33793882-12	2021	Moreover, we found that Rg3 could bind to NLRP3 suggesting the anti-inflammatory effects of Rg3 by molecular docking study.	ginsenoside Rg3	24-27	NLR family, pyrin domain containing 3	Mus musculus	42-47
33793882-12	2021	Moreover, we found that Rg3 could bind to NLRP3 suggesting the anti-inflammatory effects of Rg3 by molecular docking study.	ginsenoside Rg3	92-95	NLR family, pyrin domain containing 3	Mus musculus	42-47
33092444-5	2020	In addition, the expression of NLRP3, caspase-1, Pro-caspase-1, IL-1beta and IL-18 were increased in heart tissues of DCM mice and high glucose-treated HL-1 cells, which was repressed by GAS5 up-regulation.	Glucose	136-143	NLR family, pyrin domain containing 3	Mus musculus	31-36
32795894-10	2020	In in vitro experiments, CHBP treatment decreased NLRP3 inflammasome expression and downstream IL-1beta secretion, consistent with the in vivo results.	chbp	25-29	NLR family, pyrin domain containing 3	Mus musculus	50-55
34942323-0	2022	Protective effect of pteryxin on LPS-induced acute lung injury via modulating MAPK/NF-kappaB pathway and NLRP3 inflammasome activation.	pteryxin	21-29	NLR family, pyrin domain containing 3	Mus musculus	105-110
32572399-1	2020	prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-kappaB and NLRP3 inflammasome.	Dextran Sulfate	9-31	NLR family, pyrin domain containing 3	Mus musculus	104-109
30966861-5	2019	In addition, the small molecule kaempferol (Ka) protected mice against LPS- and SNCA-induced neurodegeneration by inhibiting NLRP3 inflammasome activation as evidenced by the fact that Ka reduced cleaved CASP1 expression and disrupted NLRP3-PYCARD-CASP1 complex assembly with concomitant decreased IL1B secretion.	kaempferol	32-42	NLR family, pyrin domain containing 3	Mus musculus	125-130
30966861-5	2019	In addition, the small molecule kaempferol (Ka) protected mice against LPS- and SNCA-induced neurodegeneration by inhibiting NLRP3 inflammasome activation as evidenced by the fact that Ka reduced cleaved CASP1 expression and disrupted NLRP3-PYCARD-CASP1 complex assembly with concomitant decreased IL1B secretion.	kaempferol	32-42	NLR family, pyrin domain containing 3	Mus musculus	235-240
31736980-0	2019	OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.	nesosteine	0-7	NLR family, pyrin domain containing 3	Mus musculus	36-41
34942323-10	2022	The binding of pteryxin to target proteins (MAPK, NF-kappaB and NLRP3) was determined based on molecular docking tests.	pteryxin	15-23	NLR family, pyrin domain containing 3	Mus musculus	64-69
34942323-13	2022	Moreover, pteryxin suppressed LPS-induced upregulation of proteins involved in MAPK/NF-kappaB signaling pathway and NLRP3 inflammasome activation.	pteryxin	10-18	NLR family, pyrin domain containing 3	Mus musculus	116-121
34942323-14	2022	The expression level of F4/80 and NLRP3 was also downregulated by pteryxin pretreatment in lung tissues.	pteryxin	66-74	NLR family, pyrin domain containing 3	Mus musculus	34-39
34942323-15	2022	Docking analysis revealed that pteryxin bound to target proteins (MAPK, NF- kappaB and NLRP3) with a fit-well pattern .	pteryxin	31-39	NLR family, pyrin domain containing 3	Mus musculus	87-92
34942323-16	2022	CONCLUSION: Pteryxin may attenuate LPS-induced acute lung injury by dampening MAPK/NF-kappaB signaling and NLRP 3 inflammasome activation.	pteryxin	12-20	NLR family, pyrin domain containing 3	Mus musculus	107-113
34740771-0	2022	Isoxanthohumol, a component of Sophora flavescens, promotes the activation of the NLRP3 inflammasome and induces idiosyncratic hepatotoxicity.	isoxanthohumol	0-14	NLR family, pyrin domain containing 3	Mus musculus	82-87
34740771-4	2022	MATERIALS AND METHODS: Western blot, Caspase-Glo  1 Inflammasome Assay, ELISA kits, Flow cytometry and FLIPRT Tetra system were used to study the effect of isoxanthohumol (IXN) on the activation of NLRP3 inflammasomes and its mechanism.	isoxanthohumol	156-170	NLR family, pyrin domain containing 3	Mus musculus	198-203
34740771-8	2022	Mechanistically, IXN promotes NLRP3-dependet apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) oligomerization and the generation of mitochondrial reactive oxygen species (mtROS) triggered by ATP.	Reactive Oxygen Species	194-217	NLR family, pyrin domain containing 3	Mus musculus	30-35
34740771-8	2022	Mechanistically, IXN promotes NLRP3-dependet apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC) oligomerization and the generation of mitochondrial reactive oxygen species (mtROS) triggered by ATP.	Adenosine Triphosphate	239-242	NLR family, pyrin domain containing 3	Mus musculus	30-35
34740771-10	2022	CONCLUSIONS: These results show that IXN enhances NLRP3 inflammasome activation by promoting the accumulation of ATP-induced mtROS and ASC oligomerization to cause IDILI, indicating that IXN may be a risk factor for liver injury caused by the clinical use of Sophora flavescens.	Adenosine Triphosphate	113-116	NLR family, pyrin domain containing 3	Mus musculus	50-55
34662667-0	2022	Pteryxin attenuates LPS-induced inflammatory responses and inhibits NLRP3 inflammasome activation in RAW264.7 cells.	pteryxin	0-8	NLR family, pyrin domain containing 3	Mus musculus	68-73
34856183-7	2022	Furthermore, hexarelin inhibited inflammatory cell infiltration, NLRP3 inflammasome activation and IL-18 production.	hexarelin	13-22	NLR family, pyrin domain containing 3	Mus musculus	65-70
34662667-12	2022	Moreover, pteryxin inhibited caspase-1 and NLRP3 activation and formation of ASC specks in RAW 264.7 cells, implying that pteryxin inhibits inflammasome assembly, which is a signal for NLRP3 inflammasome activation.	pteryxin	10-18	NLR family, pyrin domain containing 3	Mus musculus	43-48
34662667-12	2022	Moreover, pteryxin inhibited caspase-1 and NLRP3 activation and formation of ASC specks in RAW 264.7 cells, implying that pteryxin inhibits inflammasome assembly, which is a signal for NLRP3 inflammasome activation.	pteryxin	10-18	NLR family, pyrin domain containing 3	Mus musculus	185-190
34662667-12	2022	Moreover, pteryxin inhibited caspase-1 and NLRP3 activation and formation of ASC specks in RAW 264.7 cells, implying that pteryxin inhibits inflammasome assembly, which is a signal for NLRP3 inflammasome activation.	pteryxin	122-130	NLR family, pyrin domain containing 3	Mus musculus	43-48
34737012-0	2022	Physalin B ameliorates inflammatory responses in lipopolysaccharide-induced acute lung injury mice by inhibiting NF-kappaB and NLRP3 via the activation of the PI3K/Akt pathway.	physalin B	0-10	NLR family, pyrin domain containing 3	Mus musculus	127-132
34737012-19	2022	The NF-kappaB and NLRP3 pathways were inhibited through activation of the PI3K/Akt pathway due to PB pretreatment, whereas administration of PI3K inhibitors increased activation of these pathways.	physalin B	98-100	NLR family, pyrin domain containing 3	Mus musculus	18-23
34662667-12	2022	Moreover, pteryxin inhibited caspase-1 and NLRP3 activation and formation of ASC specks in RAW 264.7 cells, implying that pteryxin inhibits inflammasome assembly, which is a signal for NLRP3 inflammasome activation.	pteryxin	122-130	NLR family, pyrin domain containing 3	Mus musculus	185-190
34662667-13	2022	In conclusion, pteryxin blocks NF-kappaB/MAPK signaling, and suppresses the initiation and activation of NLRP3 thereby preventing inflammation.	pteryxin	15-23	NLR family, pyrin domain containing 3	Mus musculus	105-110
34973190-9	2022	P2X4 may induce the activation of NLRP3 inflammasomes by mediating calcium influx, thus exacerbating the inflammatory response, and inhibition of P2X4 expression can effectively block this process.	Calcium	67-74	NLR family, pyrin domain containing 3	Mus musculus	34-39
34784237-6	2022	In J774A.1 cells induced by LPS alone, paeonol reduced the levels of IL-1beta, NLRP3, p-IKK, p-IkappaBalpha, and p-p65, but did not affect ASC levels.	paeonol	39-46	NLR family, pyrin domain containing 3	Mus musculus	79-84
34784237-9	2022	These results suggest that paeonol inhibits IL-1beta production by inhibiting the activation of NLRP3 inflammasome, NF-kappaB, and MAPK signaling pathways.	paeonol	27-34	NLR family, pyrin domain containing 3	Mus musculus	96-101
34933095-7	2022	In Abeta(1-42)-, A53T-alpha-synuclein-, or Q74-induced BV-2 cells, PSS significantly inhibited NLRP3 inflammasome activation, which was attenuated by bafilomycin A1 (an autophagy inhibitor) and SHP099 (an SHP-2 inhibitor).	pss	67-70	NLR family, pyrin domain containing 3	Mus musculus	95-100
34894577-0	2022	Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP).	O, O-diacetylbritannilactone	48-79	NLR family, pyrin domain containing 3	Mus musculus	18-23
34894577-0	2022	Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP).	Sulfhydryl Compounds	122-127	NLR family, pyrin domain containing 3	Mus musculus	18-23
34894577-7	2022	In site-specific profiling, NLRP3 was identified as a covalent target of 1 and 2 for the first time, and the Cys483 of NLRP3 NACHT domain was identified as one active-site of NLRP3 cysteine residues that can be covalently modified by the alpha-methylene-gamma-lactone moiety.	Cysteine	181-189	NLR family, pyrin domain containing 3	Mus musculus	28-33
34894577-7	2022	In site-specific profiling, NLRP3 was identified as a covalent target of 1 and 2 for the first time, and the Cys483 of NLRP3 NACHT domain was identified as one active-site of NLRP3 cysteine residues that can be covalently modified by the alpha-methylene-gamma-lactone moiety.	Cysteine	181-189	NLR family, pyrin domain containing 3	Mus musculus	119-124
34894577-7	2022	In site-specific profiling, NLRP3 was identified as a covalent target of 1 and 2 for the first time, and the Cys483 of NLRP3 NACHT domain was identified as one active-site of NLRP3 cysteine residues that can be covalently modified by the alpha-methylene-gamma-lactone moiety.	Cysteine	181-189	NLR family, pyrin domain containing 3	Mus musculus	175-180
34933095-0	2022	Polygala saponins inhibit NLRP3 inflammasome-mediated neuroinflammation via SHP2-Mediated mitophagy.	Saponins	9-17	NLR family, pyrin domain containing 3	Mus musculus	26-31
34933095-7	2022	In Abeta(1-42)-, A53T-alpha-synuclein-, or Q74-induced BV-2 cells, PSS significantly inhibited NLRP3 inflammasome activation, which was attenuated by bafilomycin A1 (an autophagy inhibitor) and SHP099 (an SHP-2 inhibitor).	bafilomycin A1	150-164	NLR family, pyrin domain containing 3	Mus musculus	95-100
34933095-7	2022	In Abeta(1-42)-, A53T-alpha-synuclein-, or Q74-induced BV-2 cells, PSS significantly inhibited NLRP3 inflammasome activation, which was attenuated by bafilomycin A1 (an autophagy inhibitor) and SHP099 (an SHP-2 inhibitor).	SHP099	194-200	NLR family, pyrin domain containing 3	Mus musculus	95-100
34409550-8	2022	Emodin also inhibited the expression of NLRP3 and reduced the levels of pro-inflammatory factors, including interleukin-1 beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha).	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	40-45
34933095-8	2022	In addition, the co-localization of LC3 and ASC revealed that PSS promoted the autophagic degradation of the NLRP3 inflammasome.	pss	62-65	NLR family, pyrin domain containing 3	Mus musculus	109-114
34933095-11	2022	Collectively, the present study, for the first time, shows that PSS inhibit the NLRP3 inflammasome via SHP-2-mediated mitophagy in vitro and in vivo, which strongly suggests the therapeutic potential of PSS in various neurodegenerative diseases.	pss	64-67	NLR family, pyrin domain containing 3	Mus musculus	80-85
34933095-11	2022	Collectively, the present study, for the first time, shows that PSS inhibit the NLRP3 inflammasome via SHP-2-mediated mitophagy in vitro and in vivo, which strongly suggests the therapeutic potential of PSS in various neurodegenerative diseases.	pss	203-206	NLR family, pyrin domain containing 3	Mus musculus	80-85
34970353-12	2022	The present study demonstrated that VEGF could attenuate BP-induced apoptosis and differentiation of MC3T3 cells by regulating the NLRP3/caspase 1/GSDMD pathway.	Diphosphonates	57-59	NLR family, pyrin domain containing 3	Mus musculus	131-136
34409550-10	2022	These results suggest that emodin protected hepatocytes from APAP-induced liver injury via the upregulation of the Nrf2-mediated antioxidative stress pathway, the inhibition of the NLRP3 inflammasome, and the downregulation of the cGAS-STING signaling pathway.	Emodin	27-33	NLR family, pyrin domain containing 3	Mus musculus	181-186
34920334-10	2022	Mechanistically, the inflammatory response could be alleviated by DAP in the way of inhibiting the expression levels of TLR4, p-NF-kappaB, NLRP3, ASC, Cleaved-caspase-1 (p20), mature-IL-1beta (p17), and N-GSDM.	daphnetin	66-69	NLR family, pyrin domain containing 3	Mus musculus	139-144
34619319-0	2022	Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-kappaB and NLRP3 inflammasome.	Uric Acid	42-58	NLR family, pyrin domain containing 3	Mus musculus	126-131
34269108-4	2022	Notably, the enrichment of genes associated with the NOD, LRR, and NLRP3 pyrin domain-containing protein 3 (NLRP3) inflammasome pathway is downregulated after CBD treatment.	Cannabidiol	159-162	NLR family, pyrin domain containing 3	Mus musculus	108-113
34269108-8	2022	Our results demonstrate that CBD accelerates oral ulcer healing by inhibiting CMPK2-mediated NLRP3 inflammasome activation and pyroptosis, which are mediated mostly by PPARgamma in the nucleus and partially by CB1 in the plasma membrane.	Cannabidiol	29-32	NLR family, pyrin domain containing 3	Mus musculus	93-98
34601084-9	2022	Furthermore, FTF-EtOH up-regulated Nrf2 and its downstream genes through enhancing the stability of Nrf2 protein, and inhibited the activation of NF-kappaB and NLRP3 inflammasome, which have been confirmed by detecting the protein levels in the mouse model.	Ethanol	17-21	NLR family, pyrin domain containing 3	Mus musculus	160-165
34601084-11	2022	The protection of FTF-EtOH against inflammation was produced by activation of Nrf2 and inhibitions of NF-kappaB and NLRP3 inflammasome.	Ethanol	22-26	NLR family, pyrin domain containing 3	Mus musculus	116-121
34601084-0	2022	The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-kappaB.	Ethanol	4-11	NLR family, pyrin domain containing 3	Mus musculus	131-136
34619319-3	2022	AIM OF STUDY: The purpose of this study is to investigate the effects of GSZD on peritoneal recruitment of neutrophils, production of proinflammatory mediators, activations of nuclear factor (NF)-kappaB and nucleotide oligomerization domain-like receptor protein-3 (NLRP3) inflammasome in mice with monosodium urate crystal (MSU)-induced peritonitis (MIP).	monosodium urate crystal	299-323	NLR family, pyrin domain containing 3	Mus musculus	266-271
34619319-15	2022	CONCLUSIONS: These results suggest that GSZD attenuates the MSU-induced inflammation through inhibiting the activations of NF-kappaB and NLRP3 inflammasome.	msu	60-63	NLR family, pyrin domain containing 3	Mus musculus	137-142
34904823-4	2022	Initial priming of microglial cells with LPS following treatment with H2O2 induced NF-kappaB translocation to the nucleus with a robust generation of free radicals that act as signal 2 in augmenting NLRP3 inflammasome assembly and its downstream targets.	Hydrogen Peroxide	70-74	NLR family, pyrin domain containing 3	Mus musculus	199-204
34896151-5	2022	Moreover, sCPA reduced oxidative stress via regulating SOD and MDA levels, and decreased the contents of inflammatory proteins NF-kappaB and NLRP3 and adjusted TNF-alpha, IFN-gamma, IL-1beta, and IL-10 inflammatory cytokines.	SCPA	10-14	NLR family, pyrin domain containing 3	Mus musculus	141-146
34974110-0	2022	High glutamate concentration reverses the inhibitory effect of microglial adenosine 2A receptor on NLRP3 inflammasome assembly and activation.	Glutamic Acid	5-14	NLR family, pyrin domain containing 3	Mus musculus	99-104
34974110-6	2022	The results showed that pharmacological A2AR activation ameliorated NLRP3 activation under no or low glutamate concentrations, but this effect was reversed by high glutamate concentrations.	Glutamic Acid	101-110	NLR family, pyrin domain containing 3	Mus musculus	68-73
34974110-6	2022	The results showed that pharmacological A2AR activation ameliorated NLRP3 activation under no or low glutamate concentrations, but this effect was reversed by high glutamate concentrations.	Glutamic Acid	164-173	NLR family, pyrin domain containing 3	Mus musculus	68-73
34974110-8	2022	We further demonstrated that A2AR activation inhibited the interaction between NLRP3 and caspase 1 under no or low glutamate concentrations while promoting their interaction under high glutamate concentrations.	Glutamic Acid	115-124	NLR family, pyrin domain containing 3	Mus musculus	79-84
34974110-10	2022	In conclusion, our findings proved that the high glutamate concentration could reverse the inhibition of A2AR on NLRP3 inflammasome activation by modulating its assembly, which provides new insights into the regulatory effect of A2AR on neuroinflammation under different pathological conditions.	Glutamic Acid	49-58	NLR family, pyrin domain containing 3	Mus musculus	113-118
34904823-0	2022	Perillyl Alcohol Attenuates NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental In Vitro and In Vivo Models of Parkinson"s Disease.	perillyl alcohol	0-16	NLR family, pyrin domain containing 3	Mus musculus	28-33
34904823-9	2022	Further pharmacological scavenging of free radicals restricts microglia activation and simultaneously supports neuronal survival via targeting the NLRP3 inflammasome pathway in PD.	Free Radicals	38-51	NLR family, pyrin domain containing 3	Mus musculus	147-152
34904823-3	2022	Hence, the present study aimed to investigate the role of lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) in activating NLRP3 inflammasome-driven neurodegeneration and elucidated the neuroprotective role of perillyl alcohol (PA) in in vitro and in vivo models of Parkinson"s disease (PD).	Hydrogen Peroxide	87-104	NLR family, pyrin domain containing 3	Mus musculus	126-131
34904823-3	2022	Hence, the present study aimed to investigate the role of lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) in activating NLRP3 inflammasome-driven neurodegeneration and elucidated the neuroprotective role of perillyl alcohol (PA) in in vitro and in vivo models of Parkinson"s disease (PD).	Hydrogen Peroxide	106-110	NLR family, pyrin domain containing 3	Mus musculus	126-131
34890760-9	2022	Furthermore, we found that NaB significantly ameliorated glucocorticoid receptor and NLRP3 inflammasome expression.	nab	27-30	NLR family, pyrin domain containing 3	Mus musculus	85-90
34365603-9	2022	Moreover, Que administration significantly alleviated systemic and vWAT inflammation, abolished NLRP3 inflammasome activation, and improved signaling abnormalities characteristic of insulin resistance in vWAT and adipocytes.	Quercetin	10-13	NLR family, pyrin domain containing 3	Mus musculus	96-101
34365603-11	2022	Most importantly, Que administration inhibited NLRP3 inflammasome-mediated inflammation and insulin signaling in vWAT to improve these adverse effects.	Quercetin	18-21	NLR family, pyrin domain containing 3	Mus musculus	47-52
34896185-6	2022	In vivo study demonstrated that DADS significantly ameliorated liver damage in mice challenged with LPS, as shown by the inhibition of increases in serum aminotransferase activities, neutrophil infiltration, and NF-kappaB and NLRP3 inflammasome activation.	diallyl disulfide	32-36	NLR family, pyrin domain containing 3	Mus musculus	226-231
34861244-13	2022	In vitro, MaR1 could significantly suppressed the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome, GSDMD-N, and IL-1beta caused by LPS and nigericin stimulation in BMDMs.	Nigericin	163-172	NLR family, pyrin domain containing 3	Mus musculus	64-100
34861244-13	2022	In vitro, MaR1 could significantly suppressed the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome, GSDMD-N, and IL-1beta caused by LPS and nigericin stimulation in BMDMs.	Nigericin	163-172	NLR family, pyrin domain containing 3	Mus musculus	102-107
34929351-0	2022	Bisphenol A induces pyroptotic cell death via ROS/NLRP3/Caspase-1 pathway in osteocytes MLO-Y4.	bis(4-hydroxyphenyl)sulfone	0-9	NLR family, pyrin domain containing 3	Mus musculus	50-55
34767031-9	2022	Moreover, the Nrf2/HO-1 axis inhibited the activation of NLRP2 inflammasome and NLRP3 overexpression reversed the effect of Dex.	Dexmedetomidine	124-127	NLR family, pyrin domain containing 3	Mus musculus	80-85
34929351-10	2022	Collectively, our data suggest that BPA causes pyroptotic death of osteocytes via ROS/NLRP3/Caspase-1 pathway.	bisphenol A	36-39	NLR family, pyrin domain containing 3	Mus musculus	86-91
34767031-10	2022	CONCLUSION: In conclusion, Dex promoted M2-polarization of microglia and attenuated oxidative stress and inflammation, and thus protected against cerebral ischemic injury by activating the Nrf2/HO-1 pathway and inhibiting NLRP3 inflammasome.	Dexmedetomidine	27-30	NLR family, pyrin domain containing 3	Mus musculus	222-227
34767031-0	2022	Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway.	Dexmedetomidine	0-15	NLR family, pyrin domain containing 3	Mus musculus	148-153
34866334-6	2022	In addition, inhibition of NF-kappaB by the small molecule inhibitor Bay-11-7082 led to lower levels of NLRP3 inflammasomes and cleaved caspase-1 proteins in BV2 cells after oxygen-glucose deprivation and reoxygenation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	69-80	NLR family, pyrin domain containing 3	Mus musculus	104-109
34961984-6	2022	Our findings indicated that, in the EAE spinal cord, tibolone reversed the astrocytic and microglial reaction, and reduced the hyperexpression of TLR4 and HMGB1, as well as NLR family pyrin domain containing 3-caspase 1-interleukin-1beta inflammasome activation.	tibolone	53-61	NLR family, pyrin domain containing 3	Mus musculus	173-209
34586567-0	2022	Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU.	gentiopicroside	11-26	NLR family, pyrin domain containing 3	Mus musculus	44-49
34586567-0	2022	Effects of Gentiopicroside on activation of NLRP3 inflammasome in acute gouty arthritis mice induced by MSU.	Uric Acid	104-107	NLR family, pyrin domain containing 3	Mus musculus	44-49
34586567-7	2022	And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS.	Uric Acid	177-180	NLR family, pyrin domain containing 3	Mus musculus	28-55
34586567-7	2022	And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS.	Uric Acid	177-180	NLR family, pyrin domain containing 3	Mus musculus	57-62
34586567-7	2022	And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS.	gentiopicroside	214-217	NLR family, pyrin domain containing 3	Mus musculus	28-55
34586567-7	2022	And the over-expressions of NOD-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and Caspase-1 induced by MSU were inhibited by treatment with GPS.	gentiopicroside	214-217	NLR family, pyrin domain containing 3	Mus musculus	57-62
34478049-0	2022	Caffeine Inhibits Activation of the NLRP3 Inflammasome via Autophagy to Attenuate Microglia-Mediated Neuroinflammation in Experimental Autoimmune Encephalomyelitis.	Caffeine	0-8	NLR family, pyrin domain containing 3	Mus musculus	36-41
34478049-9	2022	Furthermore, caffeine increased the LC3-II/LC3-I levels and decreased the NLRP3 and P62 levels in EAE mice, whereas the autophagy inhibitor 3-methylamine (3-MA) blocked these effects.	Caffeine	13-21	NLR family, pyrin domain containing 3	Mus musculus	74-79
34478049-9	2022	Furthermore, caffeine increased the LC3-II/LC3-I levels and decreased the NLRP3 and P62 levels in EAE mice, whereas the autophagy inhibitor 3-methylamine (3-MA) blocked these effects.	3-methylamine	140-153	NLR family, pyrin domain containing 3	Mus musculus	74-79
34478049-10	2022	In vitro, caffeine promoted autophagy by suppressing the mechanistic target of rapamycin (mTOR) pathway and inhibited activation of the NLRP3 inflammasome.	Caffeine	10-18	NLR family, pyrin domain containing 3	Mus musculus	136-141
34478049-12	2022	Taken together, these data suggest that caffeine exerts a newly discovered effect on EAE by reducing NLRP3 inflammasome activation via the induction of autophagy in microglia.	Caffeine	40-48	NLR family, pyrin domain containing 3	Mus musculus	101-106
34586567-10	2022	Consistently, the results proved that GPS could inhibit the activation of NLRP3 inflammasome in RAW264.7 macrophages stimulated by LPS-MSU.	Uric Acid	135-138	NLR family, pyrin domain containing 3	Mus musculus	74-79
34662588-1	2022	The investigation aimed to evaluate the effects of Mcc950, an inhibitor of the NLRP3 inflammasome, on diabetic retinopathy (DR) mice.	N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide	51-57	NLR family, pyrin domain containing 3	Mus musculus	79-84
34883151-0	2022	Hyperoside suppresses NLRP3 inflammasome in Parkinson"s disease via Pituitary Adenylate Cyclase-Activating Polypeptide.	hyperoside	0-10	NLR family, pyrin domain containing 3	Mus musculus	22-27
34757579-7	2022	On the other hand, we demonstrated that there are significant decrease for expression of IDO-1, CYP27b1, NLRP1, NLRP3 and AIM2 genes in prevention and treatment groups compared to cuprizone group.	Cuprizone	180-189	NLR family, pyrin domain containing 3	Mus musculus	112-117
34883151-11	2022	Hyperoside also inhibited the inflammasome activation by reducing the expression of NLRP3, apoptosis-associated speck-like protein containing caspases recruitment domain (ASC), and caspase-1 and increased PACAP content and CREB phosphorylation in the SNpc of the mice.	hyperoside	0-10	NLR family, pyrin domain containing 3	Mus musculus	84-89
34883151-12	2022	PACAP 6-38 reversed the inhibitory effect of hyperoside on the microglia proliferation and activation of the NLRP3 inflammasome.	CHEMBL525267	0-10	NLR family, pyrin domain containing 3	Mus musculus	109-114
34883151-12	2022	PACAP 6-38 reversed the inhibitory effect of hyperoside on the microglia proliferation and activation of the NLRP3 inflammasome.	hyperoside	45-55	NLR family, pyrin domain containing 3	Mus musculus	109-114
34883151-13	2022	These results indicate that hyperoside can inhibit the activation of the NLRP3 inflammasome by up-regulating PACAP, thus effectively inhibiting MPTP-induced neuroinflammation and protecting DA neurons.	hyperoside	28-38	NLR family, pyrin domain containing 3	Mus musculus	73-78
34883151-13	2022	These results indicate that hyperoside can inhibit the activation of the NLRP3 inflammasome by up-regulating PACAP, thus effectively inhibiting MPTP-induced neuroinflammation and protecting DA neurons.	pacap	109-114	NLR family, pyrin domain containing 3	Mus musculus	73-78
34883151-13	2022	These results indicate that hyperoside can inhibit the activation of the NLRP3 inflammasome by up-regulating PACAP, thus effectively inhibiting MPTP-induced neuroinflammation and protecting DA neurons.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	144-148	NLR family, pyrin domain containing 3	Mus musculus	73-78
34883151-13	2022	These results indicate that hyperoside can inhibit the activation of the NLRP3 inflammasome by up-regulating PACAP, thus effectively inhibiting MPTP-induced neuroinflammation and protecting DA neurons.	Dopamine	190-192	NLR family, pyrin domain containing 3	Mus musculus	73-78
34953939-0	2022	Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-kappaB.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	127-132
34798522-8	2022	CONCLUSION: BDG effectively inhibited the apoptosis of intestinal epithelial cells and suppressed the activation of the NLRP3 inflammasome which resulted in the restoration of the intestinal barrier.	O(6)-n-butyldeoxyguanosine	12-15	NLR family, pyrin domain containing 3	Mus musculus	120-125
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	NLR family, pyrin domain containing 3	Mus musculus	99-147
34953939-13	2022	In addition, the absence of Nrf2 abolished the suppressive effect of hydrogen on the expression of Nacht, Lrr, and Pyd domains-containing protein 3 (NLRP3) pathway members and p65 NF-kappaB after HI.	Hydrogen	69-77	NLR family, pyrin domain containing 3	Mus musculus	149-154
34953939-14	2022	Taken together, our findings showed that hydrogen alleviated cellular injury and apoptosis, neurobehavioural deficits, the inflammatory response and oxidative stress via the Nrf2-mediated NLRP3 and NF-kappaB pathways.	Hydrogen	41-49	NLR family, pyrin domain containing 3	Mus musculus	188-193
34987507-0	2021	Intracellular NAD+ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation.	NAD	14-18	NLR family, pyrin domain containing 3	Mus musculus	58-63
34718095-0	2022	Aurantio-obtusin induces hepatotoxicity through activation of NLRP3 inflammasome signaling.	aurantio-obtusin	0-16	NLR family, pyrin domain containing 3	Mus musculus	62-67
34718095-10	2022	In conclusion, AO induced hepatotoxicity by activating NLRP3 inflammasome signaling, at least in part, through increased KCNN4 and ROS production, and NF-kappaB inhibition.	aurantio-obtusin	15-17	NLR family, pyrin domain containing 3	Mus musculus	55-60
34718095-10	2022	In conclusion, AO induced hepatotoxicity by activating NLRP3 inflammasome signaling, at least in part, through increased KCNN4 and ROS production, and NF-kappaB inhibition.	Reactive Oxygen Species	131-134	NLR family, pyrin domain containing 3	Mus musculus	55-60
34987507-7	2021	FK866 plus nigericin stimulation caused an NLRP3-dependent assembly of inflammasome complex.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	0-5	NLR family, pyrin domain containing 3	Mus musculus	43-48
34987391-0	2021	Methyl Gallate Improves Hyperuricemia Nephropathy Mice Through Inhibiting NLRP3 Pathway.	methyl gallate	0-14	NLR family, pyrin domain containing 3	Mus musculus	74-79
34987507-5	2021	Instead, FK866 facilitated robust caspase-1 activation in BMDMs in the presence of NLRP3-activating signals such as ATP and nigericin, a potassium ionophore.	Adenosine Triphosphate	116-119	NLR family, pyrin domain containing 3	Mus musculus	83-88
34987507-7	2021	FK866 plus nigericin stimulation caused an NLRP3-dependent assembly of inflammasome complex.	Nigericin	11-20	NLR family, pyrin domain containing 3	Mus musculus	43-48
34987507-5	2021	Instead, FK866 facilitated robust caspase-1 activation in BMDMs in the presence of NLRP3-activating signals such as ATP and nigericin, a potassium ionophore.	Nigericin	124-133	NLR family, pyrin domain containing 3	Mus musculus	83-88
34987507-5	2021	Instead, FK866 facilitated robust caspase-1 activation in BMDMs in the presence of NLRP3-activating signals such as ATP and nigericin, a potassium ionophore.	Potassium	137-146	NLR family, pyrin domain containing 3	Mus musculus	83-88
34987507-6	2021	However, this FK866-mediated caspase-1 activation was completely abolished in Nlrp3-deficient macrophages.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	14-19	NLR family, pyrin domain containing 3	Mus musculus	78-83
34955683-0	2021	IL-38 Alleviates Inflammation in Sepsis in Mice by Inhibiting Macrophage Apoptosis and Activation of the NLRP3 Inflammasome.	il-38	0-5	NLR family, pyrin domain containing 3	Mus musculus	105-110
34955647-0	2021	Angiotensin-(1-7) Analogue AVE0991 Modulates Astrocyte-Mediated Neuroinflammation via lncRNA SNHG14/miR-223-3p/NLRP3 Pathway and Offers Neuroprotection in a Transgenic Mouse Model of Alzheimer"s Disease.	AVE 0991	27-34	NLR family, pyrin domain containing 3	Mus musculus	111-116
34955647-13	2021	Conclusion: Our results suggest that Ang-(1-7) analogue AVE0991 inhibits astrocyte-mediated neuroinflammation via SNHG14/miR-223-3p/NLRP3 pathway and offers neuroprotection in APP/PS1 mice.	AVE 0991	56-63	NLR family, pyrin domain containing 3	Mus musculus	132-137
34916479-10	2021	Using xenograft mouse models, we found that galangin exposure further restrained cancer development after 5-FU treatment and increased sensitivity to chemotherapy by suppressing the NLRP3 inflammasome pathway.	galangin	44-52	NLR family, pyrin domain containing 3	Mus musculus	182-187
34916479-11	2021	CONCLUSIONS Our results indicated that galangin played a synergistic anticancer role through NLRP3 inflammasome inhibition when paired with FU-5.	galangin	39-47	NLR family, pyrin domain containing 3	Mus musculus	93-98
34916479-11	2021	CONCLUSIONS Our results indicated that galangin played a synergistic anticancer role through NLRP3 inflammasome inhibition when paired with FU-5.	fu-5	140-144	NLR family, pyrin domain containing 3	Mus musculus	93-98
34955683-5	2021	Moreover, exposure to IL-38 alone was sufficient to inhibit macrophage apoptosis and LPS-driven activation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome.	il-38	22-27	NLR family, pyrin domain containing 3	Mus musculus	114-155
34955683-5	2021	Moreover, exposure to IL-38 alone was sufficient to inhibit macrophage apoptosis and LPS-driven activation of the NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) inflammasome.	il-38	22-27	NLR family, pyrin domain containing 3	Mus musculus	157-162
34955683-9	2021	Collectively, these findings present IL-38 as a potent immune modulator that restrains the inflammatory response by suppressing macrophage apoptosis and activation of the NLRP3 inflammasome.	il-38	37-42	NLR family, pyrin domain containing 3	Mus musculus	171-176
34637786-6	2021	Furthermore, TRPV4 inhibitor HC067047 reduced the activation of astrocyte and microglia, decreased expression of CaMKII-NLRP3 inflammasome and increased the expression of neurogenesis marker DCX in the hippocampus.	HC-067047	29-37	NLR family, pyrin domain containing 3	Mus musculus	120-125
34987507-12	2021	Collectively, our data suggest that NAD+ depletion provides a non-transcriptional priming signal for NLRP3 activation via mitochondrial perinuclear clustering, and aging-associated NAD+ decline can trigger NLRP3 inflammasome activation in ATP-rich environments.	NAD	36-40	NLR family, pyrin domain containing 3	Mus musculus	101-106
34987507-12	2021	Collectively, our data suggest that NAD+ depletion provides a non-transcriptional priming signal for NLRP3 activation via mitochondrial perinuclear clustering, and aging-associated NAD+ decline can trigger NLRP3 inflammasome activation in ATP-rich environments.	NAD	181-185	NLR family, pyrin domain containing 3	Mus musculus	206-211
34987507-12	2021	Collectively, our data suggest that NAD+ depletion provides a non-transcriptional priming signal for NLRP3 activation via mitochondrial perinuclear clustering, and aging-associated NAD+ decline can trigger NLRP3 inflammasome activation in ATP-rich environments.	Adenosine Triphosphate	239-242	NLR family, pyrin domain containing 3	Mus musculus	206-211
34907173-6	2021	Further research revealed that TRPV1 channel regulated ATP-induced NLRP3 inflammasome activation through mediating Ca2+ influx and phosphorylation of phosphatase PP2A in microglia.	Adenosine Triphosphate	55-58	NLR family, pyrin domain containing 3	Mus musculus	67-72
34774873-7	2021	Moreover, nuclear factor-kappa B (NF-kappaB)-dependent priming of the NLRP3 inflammasome was partially inhibited by TAK875 and AMG1638.	amg1638	127-134	NLR family, pyrin domain containing 3	Mus musculus	70-75
34774873-8	2021	The intracellular Ca2+ increase caused by ATP, nigericin (pore-forming toxin), or endoplasmic reticulum stress activates the NLRP3 inflammasome.	Adenosine Triphosphate	42-45	NLR family, pyrin domain containing 3	Mus musculus	125-130
34774873-8	2021	The intracellular Ca2+ increase caused by ATP, nigericin (pore-forming toxin), or endoplasmic reticulum stress activates the NLRP3 inflammasome.	Nigericin	47-56	NLR family, pyrin domain containing 3	Mus musculus	125-130
34774873-11	2021	These findings indicate that the free fatty acid-sensing GPR40 plays a key role in the NLRP3 inflammasome pathway.	Fatty Acids	38-48	NLR family, pyrin domain containing 3	Mus musculus	87-92
34774873-4	2021	Interestingly, we found that two GPR40 agonists, TAK875 and AMG1638, suppressed activation of the NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs).	TAK-875	49-55	NLR family, pyrin domain containing 3	Mus musculus	98-103
34774873-4	2021	Interestingly, we found that two GPR40 agonists, TAK875 and AMG1638, suppressed activation of the NLRP3 inflammasome in bone marrow-derived macrophages (BMDMs).	amg1638	60-67	NLR family, pyrin domain containing 3	Mus musculus	98-103
34774873-6	2021	TAK875 also suppressed NLRP3 inflammasome-induced pyroptosis of BMDMs.	TAK-875	0-6	NLR family, pyrin domain containing 3	Mus musculus	23-28
34774873-7	2021	Moreover, nuclear factor-kappa B (NF-kappaB)-dependent priming of the NLRP3 inflammasome was partially inhibited by TAK875 and AMG1638.	TAK-875	116-122	NLR family, pyrin domain containing 3	Mus musculus	70-75
34823419-3	2021	This study evaluated whether empagliflozin (EMPA) protects the pancreas from diabetes mellitus-induced injury by downregulating the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/Gasdermin D (GSDMD) pyroptosis-related inflammasome pathway in vitro and in vivo.	empagliflozin	44-48	NLR family, pyrin domain containing 3	Mus musculus	132-197
34903499-8	2021	RESULTS: DSS-induced colitis increased steatosis, inflammatory (IL-6, TNFalpha, NLRP3, MCP-1) as well as fibrotic (TGF-beta, alpha-SMA) mediator expression in HFD-FG mice.	Dextran Sulfate	9-12	NLR family, pyrin domain containing 3	Mus musculus	80-85
34817168-5	2021	Notably, the treatment of wild-type (WT) mice with genistein, a phytoestrogen, could attenuate high-fat diet (HFD)-induced liver lipid steatosis and inhibit NLRP3-GSDMD-mediated pyroptosis.	Genistein	51-60	NLR family, pyrin domain containing 3	Mus musculus	157-162
34924922-6	2021	Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1beta and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration.	Sevoflurane	31-35	NLR family, pyrin domain containing 3	Mus musculus	57-105
34924922-6	2021	Mechanistically, we found that SEVO induced formation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome and its downstream caspase 1-mediated production of IL-1beta and IL-18, which subsequently deactivated brain-derived neurotrophic factor (BDNF) to promote neurodegeneration.	Sevoflurane	31-35	NLR family, pyrin domain containing 3	Mus musculus	107-112
34924922-7	2021	Together, these data suggest that NLRP3 inflammasome is essential for SEVO-induced AD.	Sevoflurane	70-74	NLR family, pyrin domain containing 3	Mus musculus	34-39
34823419-0	2021	Empagliflozin protects diabetic pancreatic tissue from damage by inhibiting the activation of the NLRP3/caspase-1/GSDMD pathway in pancreatic beta cells: in vitro and in vivo studies.	empagliflozin	0-13	NLR family, pyrin domain containing 3	Mus musculus	98-103
34823419-3	2021	This study evaluated whether empagliflozin (EMPA) protects the pancreas from diabetes mellitus-induced injury by downregulating the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/Gasdermin D (GSDMD) pyroptosis-related inflammasome pathway in vitro and in vivo.	empagliflozin	29-42	NLR family, pyrin domain containing 3	Mus musculus	132-197
34823419-3	2021	This study evaluated whether empagliflozin (EMPA) protects the pancreas from diabetes mellitus-induced injury by downregulating the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/Gasdermin D (GSDMD) pyroptosis-related inflammasome pathway in vitro and in vivo.	empagliflozin	29-42	NLR family, pyrin domain containing 3	Mus musculus	199-204
34955826-7	2021	After constructing a tumor-bearing mice model, galloflavin was intragastrically administered, followed by detection of tumor growth, expression of NLRP3 and ASC by immunohistochemistry, and tumor histopathology by H&E staining.	galloflavin	47-58	NLR family, pyrin domain containing 3	Mus musculus	147-152
34955826-15	2021	Galloflavin could inhibit the malignant behavior of colorectal cancer cells by targeting NLRP3.	galloflavin	0-11	NLR family, pyrin domain containing 3	Mus musculus	89-94
34882936-0	2022	Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.	licochalcone B	0-14	NLR family, pyrin domain containing 3	Mus musculus	41-46
34882936-0	2022	Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.	licochalcone B	0-14	NLR family, pyrin domain containing 3	Mus musculus	79-84
34882936-2	2022	In the present study, we demonstrated that Licochalcone B (LicoB), a main component of the traditional medicinal herb licorice, is a specific inhibitor of the NLRP3 inflammasome.	licochalcone B	43-57	NLR family, pyrin domain containing 3	Mus musculus	159-164
34882936-2	2022	In the present study, we demonstrated that Licochalcone B (LicoB), a main component of the traditional medicinal herb licorice, is a specific inhibitor of the NLRP3 inflammasome.	licochalcone B	59-64	NLR family, pyrin domain containing 3	Mus musculus	159-164
34882936-3	2022	LicoB inhibits the activation of the NLRP3 inflammasome in macrophages but has no effect on the activation of AIM2 or NLRC4 inflammasome.	licochalcone B	0-5	NLR family, pyrin domain containing 3	Mus musculus	37-42
34882936-4	2022	Mechanistically, LicoB directly binds to NEK7 and inhibits the interaction between NLRP3 and NEK7, thus suppressing NLRP3 inflammasome activation.	licochalcone B	17-22	NLR family, pyrin domain containing 3	Mus musculus	83-88
34882936-4	2022	Mechanistically, LicoB directly binds to NEK7 and inhibits the interaction between NLRP3 and NEK7, thus suppressing NLRP3 inflammasome activation.	licochalcone B	17-22	NLR family, pyrin domain containing 3	Mus musculus	116-121
34882936-5	2022	Furthermore, LicoB exhibits protective effects in mouse models of NLRP3 inflammasome-mediated diseases, including lipopolysaccharide (LPS)-induced septic shock, MSU-induced peritonitis and non-alcoholic steatohepatitis (NASH).	licochalcone B	13-18	NLR family, pyrin domain containing 3	Mus musculus	66-71
34882936-6	2022	Our findings indicate that LicoB is a specific NLRP3 inhibitor and a promising candidate for treating NLRP3 inflammasome-related diseases.	licochalcone B	27-32	NLR family, pyrin domain containing 3	Mus musculus	47-52
34882936-6	2022	Our findings indicate that LicoB is a specific NLRP3 inhibitor and a promising candidate for treating NLRP3 inflammasome-related diseases.	licochalcone B	27-32	NLR family, pyrin domain containing 3	Mus musculus	102-107
34887675-0	2021	1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.	1,25-dihydroxyvitamin D	0-23	NLR family, pyrin domain containing 3	Mus musculus	105-110
34823419-3	2021	This study evaluated whether empagliflozin (EMPA) protects the pancreas from diabetes mellitus-induced injury by downregulating the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)/caspase-1/Gasdermin D (GSDMD) pyroptosis-related inflammasome pathway in vitro and in vivo.	empagliflozin	44-48	NLR family, pyrin domain containing 3	Mus musculus	199-204
34823419-11	2021	Furthermore, empagliflozin not only reduced the expression levels of NLRP3/caspase-1/GSDMD in vitro, but also reduced their expression levels in vivo.	empagliflozin	13-26	NLR family, pyrin domain containing 3	Mus musculus	69-74
34823419-12	2021	In summary, our data suggested that empagliflozin protects the pancreatic tissues from diabetes mellitus-induced injury by downregulating the NLRP3/caspase-1/GSDMD pyroptosis-related inflammasome pathway.	empagliflozin	36-49	NLR family, pyrin domain containing 3	Mus musculus	142-147
34534636-11	2021	Hesperadin pretreatment inhibited the expression of MST4 and increased the expression of NLRP3 inflammasome-medicated proteins, which aggravated neurological deficits and cerebral edema.	hesperadin	0-10	NLR family, pyrin domain containing 3	Mus musculus	89-94
34348577-2	2021	The purpose of this work is to probe into the impact of N2O on nerve cell injury through regulating thioredoxin-interacting protein (TXNIP)/the NOD-like receptor domain of pyrin containing 3 (NLRP3) pathway.	Nitrous Oxide	56-59	NLR family, pyrin domain containing 3	Mus musculus	192-197
34348577-3	2021	The results indicated that, N2O exposure elevated TXNIP/NLRP3 expression in vivo and in vitro, led to declined learning and memory capabilities in mice, reduced apoptosis rate in hippocampal neuron and Nissl bodies, elevated inflammatory factors TNF-alpha, IL-1beta and IL-6 levels, as well as cleaved caspase-3 and Bax expressions, and reduced Bcl-2 expression.	Nitrous Oxide	28-31	NLR family, pyrin domain containing 3	Mus musculus	56-61
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	40-43	NLR family, pyrin domain containing 3	Mus musculus	135-140
34348577-6	2021	All in all, the results manifested that N2O is available to promote nerve cell inflammation and apoptosis through activating the TXNIP/NLRP3 pathway that can be used as a potential target for N2O-induced nerve damage in the future.	Nitrous Oxide	192-195	NLR family, pyrin domain containing 3	Mus musculus	135-140
34738867-8	2021	Collectively, we concluded that BMSCs-exo upregulated miR-223-3p to degrade NLRP3 in EPCs, which further reversed the cytotoxic effects of LPS treatment on EPCs to ameliorate LPS-induced AUI.	mir-223-3p	54-64	NLR family, pyrin domain containing 3	Mus musculus	76-81
34747306-9	2021	The MPO activity and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1beta, and NLR family pyrin domain-containing 3) levels were also significantly reduced after DEX treatment compared with those in the ALI mice.	Dexmedetomidine	180-183	NLR family, pyrin domain containing 3	Mus musculus	97-133
34715758-9	2021	Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-alpha and IL-1beta production.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	11-19	NLR family, pyrin domain containing 3	Mus musculus	70-75
34925379-0	2021	Dl-3-n-Butylphthalide Rescues Dopaminergic Neurons in Parkinson"s Disease Models by Inhibiting the NLRP3 Inflammasome and Ameliorating Mitochondrial Impairment.	3-n-butylphthalide	0-21	NLR family, pyrin domain containing 3	Mus musculus	99-104
34715758-6	2021	Ephedrine treatment also suppressed TNF-alpha and IL-1beta production and NOD-like receptor pyrin domain 3 (NLRP3) inflammasome activation in BV2 microglial cells.	Ephedrine	0-9	NLR family, pyrin domain containing 3	Mus musculus	74-106
34715758-9	2021	Meanwhile, LY294002 attenuated the inhibitory effects of ephedrine on NLRP3 inflammasome activation and TNF-alpha and IL-1beta production.	Ephedrine	57-66	NLR family, pyrin domain containing 3	Mus musculus	70-75
34715758-6	2021	Ephedrine treatment also suppressed TNF-alpha and IL-1beta production and NOD-like receptor pyrin domain 3 (NLRP3) inflammasome activation in BV2 microglial cells.	Ephedrine	0-9	NLR family, pyrin domain containing 3	Mus musculus	108-113
34796763-10	2021	The regulation of Beclin1 participated in the effects of DAPK1 on inflammation of arterial aneurysm by ATP-dependent NLRP3 inflammasome.	Adenosine Triphosphate	103-106	NLR family, pyrin domain containing 3	Mus musculus	117-122
34715758-7	2021	The expression of NLRP3, caspase-1, and IL-1beta was suppressed by ephedrine.	Ephedrine	67-76	NLR family, pyrin domain containing 3	Mus musculus	18-23
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	14-41	NLR family, pyrin domain containing 3	Mus musculus	204-209
34420157-3	2021	In continuation with our previous findings, we have further evaluated the mechanistic role of ATN-161 in vitro and found that oxygen and glucose deprivation and reperfusion (OGD/R)-induced inflammation, oxidative stress, apoptosis, mitochondrial depolarization, and fibrosis attenuate tight junction integrity via induction of alpha5, NLRP3, p-FAK, and p-AKT signaling in mouse brain endothelial cells.	Oxygen	126-132	NLR family, pyrin domain containing 3	Mus musculus	335-340
34420157-4	2021	ATN-161 treatment (10 microM) effectively inhibited OGD/R-induced extracellular matrix (ECM) deposition by reducing integrin alpha5, MMP-9, and fibronectin expression, as well as reducing oxidative stress by reducing mitochondrial superoxide radicals, intracellular ROS, inflammation by reducing NLRP3 inflammasome, tight junction loss by reducing claudin-5 and ZO-1 expression levels, mitochondrial damage by inhibiting mitochondrial depolarization, and apoptosis via regulation of p-FAK and p-AKT levels.	acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide	0-7	NLR family, pyrin domain containing 3	Mus musculus	296-301
34741997-8	2021	The results of in vitro studies showed that cabozantinib could inhibit the inflammatory response and apoptosis of alveolar epithelial cells by inhibiting the activation of TLR4/NF-kappaB and NLRP3 inflammasome pathways.	cabozantinib	44-56	NLR family, pyrin domain containing 3	Mus musculus	191-196
34619496-4	2021	Accordingly, we focused on exploring the effect of ROCK for NLRP3 inflammasome, the results showed that VILI in C57BL/6 mice significantly increased NF-kappaB, NLRP3, ASC, caspase1 expression, and the secretion of cytokines, which was reversed by applying the ROCK Inhibitor-Y27632.	Y 27632	275-281	NLR family, pyrin domain containing 3	Mus musculus	60-65
34619496-4	2021	Accordingly, we focused on exploring the effect of ROCK for NLRP3 inflammasome, the results showed that VILI in C57BL/6 mice significantly increased NF-kappaB, NLRP3, ASC, caspase1 expression, and the secretion of cytokines, which was reversed by applying the ROCK Inhibitor-Y27632.	Y 27632	275-281	NLR family, pyrin domain containing 3	Mus musculus	160-165
34741997-10	2021	In summary, cabozantinib could alleviate lung injury through regulating the TLR4 /NF-kappaB/NLRP3 inflammasome pathway, and alleviate pulmonary fibrosis by inhibiting the TGF-beta1/Smad3 signaling pathway.	cabozantinib	12-24	NLR family, pyrin domain containing 3	Mus musculus	92-97
34740080-10	2021	Additionally, pyrrolidine dithiocarbamate (PDTC), an NF-kappaB inhibitor, ameliorated cerebral ischemia-reperfusion injury by suppressing microglial polarization towards the proinflammatory phenotype and NLRP3 activation in vivo, further suggesting that these protective effects of JLX001 were mediated by inhibition of the NF-kappaB signaling pathway.	pyrrolidine dithiocarbamic acid	43-47	NLR family, pyrin domain containing 3	Mus musculus	204-209
34676876-14	2021	Semaglutide attenuated the LPS- and nigericin-induced inflammatory response and LDH release by blocking NLRP3 inflammasome activation in BV2 cells.	Nigericin	36-45	NLR family, pyrin domain containing 3	Mus musculus	104-109
34836795-0	2021	Novel organoselenides (NSAIDs-Se derivatives) protect against LPS-induced inflammation in microglia by targeting the NOX2/NLRP3 signaling pathway.	organoselenides	6-21	NLR family, pyrin domain containing 3	Mus musculus	122-127
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	NLR family, pyrin domain containing 3	Mus musculus	247-252
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	NLR family, pyrin domain containing 3	Mus musculus	254-281
34836795-8	2021	Our finding demonstrated that organoselenium compounds derived from NSAID might play an important role in the protection of brain microglia against inflammation-related neurodegenerative disease by potentially down-regulating the NOX2/NLRP3 signaling axis.	organoselenium	30-44	NLR family, pyrin domain containing 3	Mus musculus	235-240
34810128-5	2021	Our findings demonstrated that extracellular citrate aggravated the pathological lung injury induced by LPS in mice, characterized by up-regulation of pro-inflammatory factors and over-activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in the lungs.	Citric Acid	45-52	NLR family, pyrin domain containing 3	Mus musculus	199-247
34810128-5	2021	Our findings demonstrated that extracellular citrate aggravated the pathological lung injury induced by LPS in mice, characterized by up-regulation of pro-inflammatory factors and over-activation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome in the lungs.	Citric Acid	45-52	NLR family, pyrin domain containing 3	Mus musculus	249-254
34810128-6	2021	In vitro, we found that citrate treatment significantly augmented the expression of NLRP3 and pro-IL-1beta and enhanced the translocation of NF-kappaB/p65 into the nucleus.	Citric Acid	24-31	NLR family, pyrin domain containing 3	Mus musculus	84-89
34810128-8	2021	Inhibiting the production of ROS with a ROS scavenger N-acetyl-L-cysteine (NAC) attenuated the activation of NLRP3 inflammasome.	Reactive Oxygen Species	29-32	NLR family, pyrin domain containing 3	Mus musculus	109-114
34810128-8	2021	Inhibiting the production of ROS with a ROS scavenger N-acetyl-L-cysteine (NAC) attenuated the activation of NLRP3 inflammasome.	Reactive Oxygen Species	40-43	NLR family, pyrin domain containing 3	Mus musculus	109-114
34810128-8	2021	Inhibiting the production of ROS with a ROS scavenger N-acetyl-L-cysteine (NAC) attenuated the activation of NLRP3 inflammasome.	Acetylcysteine	54-73	NLR family, pyrin domain containing 3	Mus musculus	109-114
34810128-8	2021	Inhibiting the production of ROS with a ROS scavenger N-acetyl-L-cysteine (NAC) attenuated the activation of NLRP3 inflammasome.	Acetylcysteine	75-78	NLR family, pyrin domain containing 3	Mus musculus	109-114
34810128-9	2021	Altogether, we conclude that extracellular citrate may serve as a damage-associated molecular pattern (DAMP) and aggravates LPS-induced ALI by activating the NLRP3 inflammasome.	Citric Acid	43-50	NLR family, pyrin domain containing 3	Mus musculus	158-163
34562185-8	2021	Moreover, XQ-1H or PAFR siRNA alleviated the neuronal pyroptosis induced by LPS and nigericin (an NLRP3 activator) in cortical neurons.	Nigericin	84-93	NLR family, pyrin domain containing 3	Mus musculus	98-103
34619490-13	2021	Ketamine administered at the dose of 5 mg/kg, but not at 1 mg/kg, prevented the increase on the immunocontent of NLRP3 inflammasome complex components and regulators induced by LPS or TNF-alpha administration.	Ketamine	0-8	NLR family, pyrin domain containing 3	Mus musculus	113-118
34619490-14	2021	Collectively, these findings suggest that ketamine elicits a pro-resilient phenotype against inflammatory stressors-induced depressive-like behavior, an effect associated with the suppression of the NLRP3 inflammasome-driven signaling pathway.	Ketamine	42-50	NLR family, pyrin domain containing 3	Mus musculus	199-204
34590407-0	2021	CP-25 exerts therapeutic effects in mice with dextran sodium sulfate-induced colitis by inhibiting GRK2 translocation to downregulate the TLR4-NF-kappaB-NLRP3 inflammasome signaling pathway in macrophages.	dextran sodium sulfate	46-68	NLR family, pyrin domain containing 3	Mus musculus	153-158
34619490-0	2021	The resilient phenotype elicited by ketamine against inflammatory stressors-induced depressive-like behavior is associated with NLRP3-driven signaling pathway.	Ketamine	36-44	NLR family, pyrin domain containing 3	Mus musculus	128-133
34740817-10	2021	Consistent with this finding, an NLRP3 inflammasome inhibitor (MCC950) was employed to treat OP, and modulation of pyroptosis was found to ameliorate osteoclastogenesis and bone loss in ovariectomized (OVX) mice, suggesting that UA suppressed osteoclast formation by regulating the inflammatory signal-dependent pyroptosis pathway.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	229-231	NLR family, pyrin domain containing 3	Mus musculus	33-38
34673151-0	2021	TRPM2 contributes to neuroinflammation and cognitive deficits in a cuprizone-induced multiple sclerosis model via NLRP3 inflammasome.	Cuprizone	67-76	NLR family, pyrin domain containing 3	Mus musculus	114-119
34880753-8	2021	BHBA significantly improved water maze performance; increased the ACh content, SOD activity, and SIRT1 expression; and decreased AChE and LDH activity, ROS, MDA, IL-1beta, TNF-alpha contents, and NLRP3 expression.	3-Hydroxybutyric Acid	0-4	NLR family, pyrin domain containing 3	Mus musculus	196-201
34726583-12	2021	CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression.	th2	26-29	NLR family, pyrin domain containing 3	Mus musculus	86-91
34656886-0	2021	Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1beta inflammation signal in pancreatic beta cells by regulating AMPK and autophagy.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-11	NLR family, pyrin domain containing 3	Mus musculus	69-74
34656886-10	2021	RESULTS: UA significantly inhibited IL-1beta secretion and TXNIP/NLRP3 expression in the pancreas of diabetic mice and in MIN6 pancreatic cells.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	9-11	NLR family, pyrin domain containing 3	Mus musculus	65-70
34656886-12	2021	UA activated autophagy to inhibit TXNIP/NLRP3 IL-1beta inflammatory signal, an effect that was reversed by CQ.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-2	NLR family, pyrin domain containing 3	Mus musculus	40-45
34656886-15	2021	In this study, verapamil (as positive control) inhibited NLRP3 /IL-1beta signaling in MIN6 cells.	Verapamil	15-24	NLR family, pyrin domain containing 3	Mus musculus	57-62
34873416-9	2021	Moreover, we found that in the treatment of GL, three weeks of UCA irradiation and six weeks caused no significant difference in the pathological manifestations and ganglion cells of mice, while after six weeks of irradiation, the level of NLRP3 in mice increased.	uca	63-66	NLR family, pyrin domain containing 3	Mus musculus	240-245
34815367-9	2022	BT reduced the secretion of inflammatory factors and blocked the P2X7r-NLRP3 signaling pathway.	betulin	0-2	NLR family, pyrin domain containing 3	Mus musculus	71-76
34829721-0	2021	Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	142-147
34881312-0	2021	MiR-17-5p Inhibits TXNIP/NLRP3 Inflammasome Pathway and Suppresses Pancreatic beta-Cell Pyroptosis in Diabetic Mice.	mir-17-5p	0-9	NLR family, pyrin domain containing 3	Mus musculus	25-30
34881312-12	2021	Conclusion: Our results demonstrated that miR-17-5p improves glucose tolerance, and pancreatic beta-cell function and inhibits TXNIP/NLRP3 inflammasome pathway-related pyroptosis in DM mice.	mir-17-5p	42-51	NLR family, pyrin domain containing 3	Mus musculus	133-138
34876932-0	2021	miR-29a-5p Alleviates Traumatic Brain Injury- (TBI-) Induced Permeability Disruption via Regulating NLRP3 Pathway.	mir-29a-5p	0-10	NLR family, pyrin domain containing 3	Mus musculus	100-105
34876932-12	2021	NLRP3 inhibition and miR-29a-5p silencing together caused significantly decreased FITC concentration and increased TEER value and release of IL-1beta and IL-18.	Fluorescein-5-isothiocyanate	82-86	NLR family, pyrin domain containing 3	Mus musculus	0-5
34876932-13	2021	miR-29a-5p mimic alleviated the BBB and cerebral water content and inactivates NLRP3 in the mouse TBI model.	mir-29a-5p	0-10	NLR family, pyrin domain containing 3	Mus musculus	79-84
34876932-14	2021	Conclusions: miR-29a-5p mimics protect TBI-induced increased endothelial cell permeability and BBB dysfunction via suppressing NLRP3 expression and activation.	mir-29a-5p	13-23	NLR family, pyrin domain containing 3	Mus musculus	127-132
34899337-0	2021	Entinostat Improves Motor Function and Neuronal Damage Via Downregulating NLRP3 Inflammasome Activation After Spinal Cord Injury.	entinostat	0-10	NLR family, pyrin domain containing 3	Mus musculus	74-79
34899337-5	2021	Results: The results showed that entinostat suppressed HDAC activation (including HDAC1 and HDAC3 expression), improved the grip strength and BMS score, spinal edema, cell death, and local NLRP3 inflammasome activation in the spinal cord following SCI.	entinostat	33-43	NLR family, pyrin domain containing 3	Mus musculus	189-194
34899337-6	2021	Furthermore, entinostat significantly increased OGD-inhibited neuronal activity and decreased PI-positive cells, HDAC activation, caspase-1 activation, IL-1beta and IL-18 levels, and NLRP3 expression.	entinostat	13-23	NLR family, pyrin domain containing 3	Mus musculus	183-188
34899337-7	2021	Conclusion: In summary, we first documented that entinostat improved the motor function, histopathologic damage, and local inflammatory response and NLRP3 inflammasome activation in the spinal cord following SCI and also presented the neuroprotective role of OGD-induced neuronal damage via the NLRP3 inflammasome.	entinostat	49-59	NLR family, pyrin domain containing 3	Mus musculus	149-154
34899337-7	2021	Conclusion: In summary, we first documented that entinostat improved the motor function, histopathologic damage, and local inflammatory response and NLRP3 inflammasome activation in the spinal cord following SCI and also presented the neuroprotective role of OGD-induced neuronal damage via the NLRP3 inflammasome.	entinostat	49-59	NLR family, pyrin domain containing 3	Mus musculus	295-300
34782991-13	2022	RESULTS: The results showed that low doses of Dex suppress NLRP3 and interleukin-1beta in both terms.	Dexmedetomidine	46-49	NLR family, pyrin domain containing 3	Mus musculus	59-64
34807349-9	2022	SYR also suppressed LPS-induced pyroptosis in RAW 264.7 cells by inhibiting the activation of the NLRP3 inflammasome, which was abolished by an oestrogen receptor-beta (ERbeta) antagonist (PHTPP).	PHTPP	189-194	NLR family, pyrin domain containing 3	Mus musculus	98-103
34809705-4	2021	On the other hand, a remarkable increase in the expression levels of NOD-like receptor pyrin domain-containing protein (NLRP) 3, ASC, and Cleaved Caspase (Cas)-1 protein was observed in the MPs treated group.	6-trimethylsilylthio-9-trimethylsilylpurine	190-193	NLR family, pyrin domain containing 3	Mus musculus	69-127
34644617-10	2021	Altogether, deficiency of PDE4B inhibit the inflammasome activation and pyroptosis in LPS stimulated lung injury model and macrophages by regulating ROS/Nrf2/NLRP3 activation.	ros	149-152	NLR family, pyrin domain containing 3	Mus musculus	158-163
34787801-9	2022	In vitro, we demonstrated that emodin could inhibit NLRP3 and then inhibit the expression of ASC, CASP1, GSDMD, IL-1beta, and IL-18.	Emodin	31-37	NLR family, pyrin domain containing 3	Mus musculus	52-57
34787801-10	2022	In vivo, we confirmed that emodin had protective effects on LPS-induced ALI and inhibitory effects on NLRP3 inflammasome -dependent pyroptosis.	Emodin	27-33	NLR family, pyrin domain containing 3	Mus musculus	102-107
34787801-11	2022	Emodin showed excellent protective effects against LPS-induced ALI by regulating the NLRP3 inflammasome-dependent pyroptosis signaling pathway.	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	85-90
34797502-6	2022	MCC950 (NLRP3 inhibitor) and Z-YVAD-FMK (Caspase-1 inhibitor) were used to treat astrocytes to inhibit the activity of NLRP3 and Caspase-1.	benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone	29-39	NLR family, pyrin domain containing 3	Mus musculus	119-124
34789781-3	2021	Deletion of the endosomal adaptor protein APPL1 impairs mitophagy, leading to accumulation of damaged mitochondria producing reactive oxygen species (ROS) and oxidized cytosolic mitochondrial DNA, which in turn trigger NLRP3 inflammasome overactivation in macrophages.	Reactive Oxygen Species	125-148	NLR family, pyrin domain containing 3	Mus musculus	219-224
34789781-3	2021	Deletion of the endosomal adaptor protein APPL1 impairs mitophagy, leading to accumulation of damaged mitochondria producing reactive oxygen species (ROS) and oxidized cytosolic mitochondrial DNA, which in turn trigger NLRP3 inflammasome overactivation in macrophages.	Reactive Oxygen Species	150-153	NLR family, pyrin domain containing 3	Mus musculus	219-224
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	NLR family, pyrin domain containing 3	Mus musculus	48-53
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	NLR family, pyrin domain containing 3	Mus musculus	85-90
34868022-0	2021	Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma.	ros	82-85	NLR family, pyrin domain containing 3	Mus musculus	96-101
34858188-8	2021	We also found that farrerol alleviated inflammation and renal fibrosis by inhibiting p-NF-kappaB/NLRP3 and TGF-beta/Smad signaling.	farrerol	19-27	NLR family, pyrin domain containing 3	Mus musculus	97-102
34869071-9	2021	Inhibition assays with glyburide and CA-074 methyl ester (K+ outflow inhibitor and cathepsin B inhibitor) blocked IL-1beta secretion, which demonstrated the essential role of the NLRP3 inflammasome in inflammatory response.	Glyburide	23-32	NLR family, pyrin domain containing 3	Mus musculus	179-184
34869071-9	2021	Inhibition assays with glyburide and CA-074 methyl ester (K+ outflow inhibitor and cathepsin B inhibitor) blocked IL-1beta secretion, which demonstrated the essential role of the NLRP3 inflammasome in inflammatory response.	CA 074 methyl ester	37-56	NLR family, pyrin domain containing 3	Mus musculus	179-184
34858398-0	2021	Dimethyl Fumarate Alleviates NLRP3 Inflammasome Activation in Microglia and Sickness Behavior in LPS-Challenged Mice.	Dimethyl Fumarate	0-17	NLR family, pyrin domain containing 3	Mus musculus	29-34
34858398-3	2021	In this study, we investigated the potential use of DMF against microglial NLRP3 inflammasome activation both in vitro and in vivo.	Dimethyl Fumarate	52-55	NLR family, pyrin domain containing 3	Mus musculus	75-80
34858398-4	2021	For in vitro studies, LPS- and ATP-stimulated N9 microglial cells were used to induce NLRP3 inflammasome activation.	Adenosine Triphosphate	31-34	NLR family, pyrin domain containing 3	Mus musculus	86-91
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Dimethyl Fumarate	26-29	NLR family, pyrin domain containing 3	Mus musculus	62-67
34741555-5	2022	Further experiments revealed that dynamin-related protein 1 (Drp1)-mediated excessive mitochondrial fission induced overproduction of reactive oxygen species in the retinal cells, leading to apoptosis, activation of microglia, and formation of the NLRP3 inflammasome.	Oxygen	143-149	NLR family, pyrin domain containing 3	Mus musculus	248-253
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Dimethyl Fumarate	26-29	NLR family, pyrin domain containing 3	Mus musculus	136-141
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Adenosine Triphosphate	50-53	NLR family, pyrin domain containing 3	Mus musculus	62-67
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Adenosine Triphosphate	50-53	NLR family, pyrin domain containing 3	Mus musculus	136-141
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Oxygen	159-165	NLR family, pyrin domain containing 3	Mus musculus	62-67
34858398-10	2021	DMF also improved LPS-induced sickness behavior in male mice and decreased caspase-1/NLRP3 levels via Nrf2 activation.	Dimethyl Fumarate	0-3	NLR family, pyrin domain containing 3	Mus musculus	85-90
34858398-12	2021	Our results proved the effectiveness of DMF on the amelioration of microglial NLRP3 inflammasome activation.	Dimethyl Fumarate	40-43	NLR family, pyrin domain containing 3	Mus musculus	78-83
34827648-4	2021	In addition, similar inhibition effects were observed in the iNOS-induced COX-2 mediated pathway and NLRP3 inflammasome pathway of MDI-stimulated 3T3-L1 cells treated with alpha-cubebenol.	alpha-cubebenol	172-187	NLR family, pyrin domain containing 3	Mus musculus	101-106
34820388-0	2021	GSDMD Mediates LPS-Induced Septic Myocardial Dysfunction by Regulating ROS-dependent NLRP3 Inflammasome Activation.	Reactive Oxygen Species	71-74	NLR family, pyrin domain containing 3	Mus musculus	85-90
34820388-10	2021	Further research showed that in the myocardium of LPS-induced septic mice, GSDMD-NT enrichment in mitochondria led to mitochondrial dysfunction and reactive oxygen species (ROS) overproduction, which further regulated the activation of the NLRP3 inflammasome.	Reactive Oxygen Species	148-171	NLR family, pyrin domain containing 3	Mus musculus	240-245
34820388-10	2021	Further research showed that in the myocardium of LPS-induced septic mice, GSDMD-NT enrichment in mitochondria led to mitochondrial dysfunction and reactive oxygen species (ROS) overproduction, which further regulated the activation of the NLRP3 inflammasome.	Reactive Oxygen Species	173-176	NLR family, pyrin domain containing 3	Mus musculus	240-245
34820428-4	2021	In vitro, flow cytometry shows that Cd exposure promotes M1-type polarization of macrophages, manifested as the increasing expressions of nuclear Factor kappa-light-chain-enhancer of activated B (NF-kB) and NLR family pyrin domain containing 3 (NLRP3).	Cadmium	36-38	NLR family, pyrin domain containing 3	Mus musculus	207-243
34820428-4	2021	In vitro, flow cytometry shows that Cd exposure promotes M1-type polarization of macrophages, manifested as the increasing expressions of nuclear Factor kappa-light-chain-enhancer of activated B (NF-kB) and NLR family pyrin domain containing 3 (NLRP3).	Cadmium	36-38	NLR family, pyrin domain containing 3	Mus musculus	245-250
34827148-11	2021	Moreover, Vit C was able to reduce NLRP3 activation, which is linked to the pathogenesis of many inflammatory diseases, including neuroinflammatory disorders.	Ascorbic Acid	10-15	NLR family, pyrin domain containing 3	Mus musculus	35-40
34803702-9	2021	More importantly, the inhibition of TLR4/MyD88/NF-kappaB pathway and NLRP3 expression was also confirmed in MSU-induced Raw264.7 cells.	Uric Acid	108-111	NLR family, pyrin domain containing 3	Mus musculus	69-74
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Flavonoids	55-65	NLR family, pyrin domain containing 3	Mus musculus	200-205
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Flavonoids	7-17	NLR family, pyrin domain containing 3	Mus musculus	144-149
34803702-10	2021	In conclusion, these results indicated that the active flavonoids from L. brachystachya could effectively attenuate gouty arthritis induced by MSU crystal through the TLR4/MyD88/NF-kappaB pathway and NLRP3 expression in vivo and in vitro, suggesting several potential candidates for the treatment of gouty arthritis.	Uric Acid	143-146	NLR family, pyrin domain containing 3	Mus musculus	200-205
34803702-0	2021	Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-kappaB Pathway and NLRP3 Expression.	Uric Acid	55-71	NLR family, pyrin domain containing 3	Mus musculus	144-149
34585633-10	2021	NLRP3 overexpression inhibited the beneficial effects of CWA on the heart during DCM and on high glucose-induced myocyte injury.	Glucose	97-104	NLR family, pyrin domain containing 3	Mus musculus	0-5
34735466-6	2021	Inhibiting IDO-1 with 1-MT or INCB24360 increased IL-1beta secretion and suppressed NLRP3 expression in RAW264.7/BV-2 cells.	epacadostat	30-39	NLR family, pyrin domain containing 3	Mus musculus	84-89
34672194-0	2021	Ellagic Acid Exerts Beneficial Effects on Hyperuricemia by Inhibiting Xanthine Oxidase and NLRP3 Inflammasome Activation.	Ellagic Acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	91-96
34672194-8	2021	Furthermore, EA significantly inhibited the expressions of XOD and NLRP3 pathway-related proteins (TLR4, p-p65, caspase-1, TNF-alpha, and IL-18) in vitro and in vivo.	Ellagic Acid	13-15	NLR family, pyrin domain containing 3	Mus musculus	67-72
34672194-9	2021	Our results indicated that EA exerts ameliorative effects in experimental hyperuricemia and foot edema via regulating the NLRP3 signaling pathway and represents a promising therapeutic option for the management of hyperuricemia.	Ellagic Acid	27-29	NLR family, pyrin domain containing 3	Mus musculus	122-127
34988203-0	2021	Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-kappaB signaling pathway.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	21-26
34988203-2	2021	Salidroside (Sal) has good anti-inflammatory effects; however, it remains unclear whether Sal can regulate NLRP3 inflammasome activation through the Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-kappaB) signaling pathway after cerebral ischemia to alleviate inflammatory injury.	rhodioloside	90-93	NLR family, pyrin domain containing 3	Mus musculus	107-112
34353430-6	2021	KHG26700 significantly attenuated the expression of several pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6, in these cells, as well as the LPS-induced increases in NLRP3, NF-kappaB, and phospho-IkBalpha levels.	khg26700	0-8	NLR family, pyrin domain containing 3	Mus musculus	221-226
34353430-8	2021	These results suggest that the anti-inflammatory effects of KHG26700 may be due, at least in part, to the regulation of the NLRP3-mediated signaling pathway during microglial activation.	khg26700	60-68	NLR family, pyrin domain containing 3	Mus musculus	124-129
34769321-12	2021	A feasible mechanism would involve that melatonin up-regulated the Faecalibacterium population and production of its metabolite butyrate and MCT1 expression and inhibited HDAC3 in the colon, which would allow p-GSK-3beta/beta-catenin/HIF-1alpha activation and NF-kappaB/NLRP3 suppression to up-regulate Card9 expression and suppress inflammation response.	Melatonin	40-49	NLR family, pyrin domain containing 3	Mus musculus	270-275
34769321-12	2021	A feasible mechanism would involve that melatonin up-regulated the Faecalibacterium population and production of its metabolite butyrate and MCT1 expression and inhibited HDAC3 in the colon, which would allow p-GSK-3beta/beta-catenin/HIF-1alpha activation and NF-kappaB/NLRP3 suppression to up-regulate Card9 expression and suppress inflammation response.	Butyrates	128-136	NLR family, pyrin domain containing 3	Mus musculus	270-275
34474337-0	2021	MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis.	Doxorubicin	18-29	NLR family, pyrin domain containing 3	Mus musculus	91-96
34474337-5	2021	Mechanismly, MCC950 had the potential to inhibit DOX-induced the cleavage of NLRP3, ASC, Caspase-1, IL-18, IL-1beta and GSDMD in vivo.	Doxorubicin	49-52	NLR family, pyrin domain containing 3	Mus musculus	77-82
34474337-7	2021	Taken together, our findings validated that MCC950, an NLRP3 inflammasome inhibitor, has the potential to attenuate doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis.	Doxorubicin	116-127	NLR family, pyrin domain containing 3	Mus musculus	55-60
34353430-0	2021	Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells.	n-cyclooctyl-5-methylthiazol-2-amine hydrobromide	29-78	NLR family, pyrin domain containing 3	Mus musculus	154-159
34353430-3	2021	NLRP3 inflammasomes activate nuclear factor kappa-B (NF-kappaB) and reactive oxygen species (ROS), which induce inflammatory responses.	Reactive Oxygen Species	68-91	NLR family, pyrin domain containing 3	Mus musculus	0-5
34353430-3	2021	NLRP3 inflammasomes activate nuclear factor kappa-B (NF-kappaB) and reactive oxygen species (ROS), which induce inflammatory responses.	Reactive Oxygen Species	93-96	NLR family, pyrin domain containing 3	Mus musculus	0-5
34492534-8	2021	Antcin A could also inhibit the activation of NLRP3 inflammasome in liver tissue and decrease the level of inflammatory factors.	antcin A	0-8	NLR family, pyrin domain containing 3	Mus musculus	46-51
34630642-0	2021	Sinomenine hydrochloride ameliorates dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota composition whilst suppressing the activation of the NLRP3 inflammasome.	sinomenine	0-24	NLR family, pyrin domain containing 3	Mus musculus	170-175
34231604-0	2021	Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice.	ethyl acetate	68-81	NLR family, pyrin domain containing 3	Mus musculus	14-19
34231604-10	2021	The work demonstrated that the ethyl acetate fraction of Bungeanum ameliorated cognitive deficits, and its effects may be related to ameliorating oxidative stress and suppressing the NLRP3 inflammasome pathway and GSDMD-mediated pyroptosis in aging mice.	ethyl acetate	31-44	NLR family, pyrin domain containing 3	Mus musculus	183-188
34530204-14	2021	Additionally, administration of exogenous GGPP could inhibit the activation of autophagy, enhance the activity of NLRP3 inflammasome, and the production of IL-1beta and IL-18.	geranylgeranyl pyrophosphate	42-46	NLR family, pyrin domain containing 3	Mus musculus	114-119
34530204-15	2021	Inhibition of autophagy by 3-MA treatment also promoted the activity of NLRP3 inflammasome and the production of IL-1beta and IL-18.	3-methyladenine	27-31	NLR family, pyrin domain containing 3	Mus musculus	72-77
34536747-0	2021	Role of vitamin D/VDR nuclear translocation in down-regulation of NF-kappaB/NLRP3/caspase-1 axis in lupus nephritis.	Vitamin D	8-17	NLR family, pyrin domain containing 3	Mus musculus	76-81
34614429-0	2021	Aluminum impairs cognitive function by activating DDX3X-NLRP3-mediated pyroptosis signaling pathway.	Aluminum	0-8	NLR family, pyrin domain containing 3	Mus musculus	56-61
34614429-8	2021	Meanwhile, aluminum could stimulate nucleotide oligomerization domain-like receptor family pyrin domain containing protein 3 (NLRP3) inflammasome assembly and activate caspase-1 (CASP1), inducing gasdermin D (GSDMD)-mediated pyroptosis signaling, releasing cytokines IL-1beta and IL-18, further promoting the activation of glial cells to magnify neuroinflammatory response.	Aluminum	11-19	NLR family, pyrin domain containing 3	Mus musculus	126-131
34614429-11	2021	CONCLUSION: Aluminum exposure could induce nerve cell pyroptosis and neuroinflammation by DDX3X-NLRP3 inflammasome signaling pathway, which could be rescued via Rsv activating sirtuin 1 (SIRT1).	Aluminum	12-20	NLR family, pyrin domain containing 3	Mus musculus	96-101
34614429-11	2021	CONCLUSION: Aluminum exposure could induce nerve cell pyroptosis and neuroinflammation by DDX3X-NLRP3 inflammasome signaling pathway, which could be rescued via Rsv activating sirtuin 1 (SIRT1).	Resveratrol	161-164	NLR family, pyrin domain containing 3	Mus musculus	96-101
34492534-0	2021	Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3.	antcin A	0-8	NLR family, pyrin domain containing 3	Mus musculus	123-128
34492534-5	2021	Pull-down assay and immunoprecipitation assay were used to detect the binding between Antcin A and NLRP3.	antcin A	86-94	NLR family, pyrin domain containing 3	Mus musculus	99-104
34492534-6	2021	As a result, Antcin A could significantly inhibit the occurrence of pyrolysis, decrease the expression of inflammatory factors, inhibit the activation and assembly of NLRP3 inflammasome, and significantly down-regulate the expression of NLRP3, Caspase-1 and GSDMD-NT in KCs.	antcin A	13-21	NLR family, pyrin domain containing 3	Mus musculus	167-172
34492534-6	2021	As a result, Antcin A could significantly inhibit the occurrence of pyrolysis, decrease the expression of inflammatory factors, inhibit the activation and assembly of NLRP3 inflammasome, and significantly down-regulate the expression of NLRP3, Caspase-1 and GSDMD-NT in KCs.	antcin A	13-21	NLR family, pyrin domain containing 3	Mus musculus	237-242
34536747-7	2021	In 16-week-old MRL/lpr LN mice, the upregulated expression of NLRP3/caspase-1/IL-1beta/IL-18 axis was significantly downregulated after paricalcitol treatment.	paricalcitol	136-148	NLR family, pyrin domain containing 3	Mus musculus	62-67
34492534-9	2021	In the study of mechanism, we revealed that Antcin A could inhibit the assembly and activation of NLRP3 inflammasome by binding with NLRP3.	antcin A	44-52	NLR family, pyrin domain containing 3	Mus musculus	98-103
34536747-8	2021	Paricalcitol can reverse the apoptosis induced by anti-dsDNA antibody via the NF-kappaB/NLRP3/caspase-1/IL-1beta/IL-18 axis in mRTECs.	paricalcitol	0-12	NLR family, pyrin domain containing 3	Mus musculus	88-93
34492534-9	2021	In the study of mechanism, we revealed that Antcin A could inhibit the assembly and activation of NLRP3 inflammasome by binding with NLRP3.	antcin A	44-52	NLR family, pyrin domain containing 3	Mus musculus	133-138
34492534-10	2021	In summary, in this study, we found that Antcin A could inhibit pyroptosis in KC and alleviate the inflammatory response of liver tissue in NAFLD by targeting NLRP3 inflammasome, which was one of the mechanisms of Anctin A in protecting liver.	antcin A	41-49	NLR family, pyrin domain containing 3	Mus musculus	159-164
34298481-7	2021	In confirmatory work, 3T3-L1 adipocyte pretreatment with the LC omega-3 PUFA docosahexaenoic acid (100 muM, 24 h) blunted interferon-gamma-induced (5 ng/mL, 24 h) expression of genes related to major histocompatibility complex II and priming and activity markers of the NLRP3 inflammasome compared with control (P < 0.05).	-3 pufa	69-76	NLR family, pyrin domain containing 3	Mus musculus	270-275
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	epigallocatechin gallate	0-24	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	epigallocatechin gallate	26-30	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	staphylococcal alpha-hemolysin	43-73	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	ros	122-125	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	epigallocatechin gallate	144-148	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-4	2021	In this study, we investigated the inhibitory effect of EGCG on Hla-induced NLRP3 inflammasome activation in vitro and in vivo and elucidated the potential molecular mechanism.	epigallocatechin gallate	56-60	NLR family, pyrin domain containing 3	Mus musculus	76-81
34562843-8	2021	Moreover, Hla-induced expression of NLRP3, ASC and caspase-1 protein and generation of IL-1beta and IL-18 in the damaged liver tissue of mice were also significantly suppressed by EGCG in a dose-dependent manner.	epigallocatechin gallate	180-184	NLR family, pyrin domain containing 3	Mus musculus	36-41
34562843-9	2021	Collectively, EGCG could be a promising candidate for alleviating Hla-induced the activation of NLRP3 inflammasome, depending on ROS mediated MAPK signaling pathway, and inhibition of Hla secretion and heptamer formation.	epigallocatechin gallate	14-18	NLR family, pyrin domain containing 3	Mus musculus	96-101
34562843-9	2021	Collectively, EGCG could be a promising candidate for alleviating Hla-induced the activation of NLRP3 inflammasome, depending on ROS mediated MAPK signaling pathway, and inhibition of Hla secretion and heptamer formation.	ros	129-132	NLR family, pyrin domain containing 3	Mus musculus	96-101
34478813-0	2021	Ginkgolide B Inhibits NLRP3 Inflammasome Activation and Promotes Microglial M2 Polarization in Abeta1-42-induced microglia cells.	ginkgolide B	0-12	NLR family, pyrin domain containing 3	Mus musculus	22-27
34478813-6	2021	We found that GB treatment ameliorated Abeta1-42-induced pathological damages and inhibited NLRP3 inflammasome activation.	ginkgolide B	14-16	NLR family, pyrin domain containing 3	Mus musculus	92-97
34478813-8	2021	Our findings suggest that GB treatment prevents the pathological processes of AD and suppresses neuroinflammation by inhibiting NLRP3 inflammasome activation and promoting microglial M2 polarization.	ginkgolide B	26-28	NLR family, pyrin domain containing 3	Mus musculus	128-133
34632701-6	2021	As a result, the administration of Sulfa-4 and Sulfa-22 could significantly inhibit the activation of microglia, decrease the expression of inflammatory factors in the central nervous system and simultaneously suppress the production of p30-GSDMD as well as the expression of upstream NLRP3 inflammasome and Caspase-1 protein.	sulfa-4	35-42	NLR family, pyrin domain containing 3	Mus musculus	285-290
34632701-6	2021	As a result, the administration of Sulfa-4 and Sulfa-22 could significantly inhibit the activation of microglia, decrease the expression of inflammatory factors in the central nervous system and simultaneously suppress the production of p30-GSDMD as well as the expression of upstream NLRP3 inflammasome and Caspase-1 protein.	sulfa-22	47-55	NLR family, pyrin domain containing 3	Mus musculus	285-290
34298481-0	2021	Dietary omega-3 polyunsaturated fatty acids modulate CD4+ T-cell subset markers, adipocyte antigen-presentation potential, and NLRP3 inflammasome activity in a coculture model of obese adipose tissue.	omega-3 polyunsaturated fatty acids	8-43	NLR family, pyrin domain containing 3	Mus musculus	127-132
34298481-7	2021	In confirmatory work, 3T3-L1 adipocyte pretreatment with the LC omega-3 PUFA docosahexaenoic acid (100 muM, 24 h) blunted interferon-gamma-induced (5 ng/mL, 24 h) expression of genes related to major histocompatibility complex II and priming and activity markers of the NLRP3 inflammasome compared with control (P < 0.05).	Docosahexaenoic Acids	77-97	NLR family, pyrin domain containing 3	Mus musculus	270-275
34583225-8	2021	RESULTS: We found that after 5% DSS treatment, the inflammation indexes and the expression of NLRP3-related proteins were increased concomitant with the loss of mucins and occludin.	Dextran Sulfate	32-35	NLR family, pyrin domain containing 3	Mus musculus	94-99
34583225-0	2021	Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-kappaB pathway.	Dextran Sulfate	29-32	NLR family, pyrin domain containing 3	Mus musculus	76-81
34782040-8	2021	Our results suggested that ASX improved hyperuricemia and kidney inflammation induced by PO and HX, probably by reducing UA synthesis and suppressing the NF-kappa B and NLRP3 pathways simultaneously.	astaxanthine	27-30	NLR family, pyrin domain containing 3	Mus musculus	169-174
34782040-0	2021	Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-kappa B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.	astaxanthine	0-11	NLR family, pyrin domain containing 3	Mus musculus	114-119
34600334-0	2021	The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of Celastrol in Parkinson"s disease.	celastrol	70-79	NLR family, pyrin domain containing 3	Mus musculus	9-14
34782040-7	2021	Furthermore, ASX administration effectively inhibited the activities of key enzymes related to UA synthesis (xanthine oxidase (XOD) and adenosine deaminase (ADA)) and modulated the protein expressions of NF-kappa B p65, p-NF-kappa B p65, Ikappa Balpha, p-Ikappa Balpha, NLRP3, ASC, Caspase-1, and cleavedCaspase-1 involved in inflammation pathways.	astaxanthine	13-16	NLR family, pyrin domain containing 3	Mus musculus	270-275
34418127-0	2021	Melatonin attenuates prostatic inflammation and pelvic pain via Sirt1-dependent inhibition of the NLRP3 inflammasome in an EAP mouse model.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	98-103
34418127-8	2021	Then, we explored the anti-inflammatory effects of melatonin on CP/CPPS by Western blotting and immunohistochemical staining, by measuring the expression of silent information regulator 1 (Sirt1) and NLRP3 inflammasome-related proteins in EAP mice.	Melatonin	51-60	NLR family, pyrin domain containing 3	Mus musculus	200-205
34418127-11	2021	Furthermore, we found that the protective effects of melatonin were achieved through activation of the Sirt1 pathway and downregulation of the NLRP3 inflammasome.	Melatonin	53-62	NLR family, pyrin domain containing 3	Mus musculus	143-148
34418127-12	2021	CONCLUSIONS: The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS.	Melatonin	40-49	NLR family, pyrin domain containing 3	Mus musculus	122-127
34418127-12	2021	CONCLUSIONS: The results indicated that melatonin could attenuate prostate inflammation and pelvic pain by inhibiting the NLRP3 inflammasomes signaling pathway through the activation of Sirt1 in mice with EAP, and these efforts should provide a promising therapeutic strategy for CP/CPPS.	phosphorylethanolamine	205-208	NLR family, pyrin domain containing 3	Mus musculus	122-127
34600334-6	2021	By using multiple genetically modified mice (Nrf2-KO, NLRP3-KO and Caspase-1-KO), we identified that celastrol inhibits NLRP3 inflammasome activation, relieves motor deficits and nigrostriatal dopaminergic degeneration through Nrf2-NLRP3-caspase-1 pathway.	celastrol	101-110	NLR family, pyrin domain containing 3	Mus musculus	54-59
34600334-6	2021	By using multiple genetically modified mice (Nrf2-KO, NLRP3-KO and Caspase-1-KO), we identified that celastrol inhibits NLRP3 inflammasome activation, relieves motor deficits and nigrostriatal dopaminergic degeneration through Nrf2-NLRP3-caspase-1 pathway.	celastrol	101-110	NLR family, pyrin domain containing 3	Mus musculus	120-125
34600334-6	2021	By using multiple genetically modified mice (Nrf2-KO, NLRP3-KO and Caspase-1-KO), we identified that celastrol inhibits NLRP3 inflammasome activation, relieves motor deficits and nigrostriatal dopaminergic degeneration through Nrf2-NLRP3-caspase-1 pathway.	celastrol	101-110	NLR family, pyrin domain containing 3	Mus musculus	232-237
34600334-7	2021	Taken together, these findings suggest that Nrf2-NLRP3-caspase-1 axis may serve as a key target of celastrol in PD treatment, and highlight the favorable properties of celastrol for neuroprotection, making celastrol as a promising disease-modifying agent for PD.	celastrol	99-108	NLR family, pyrin domain containing 3	Mus musculus	49-54
34951216-0	2021	(Rehmanniae Radix and Rehmanniae Radix Praeparata improve diabetes induced by high-fat diet coupled with streptozotocin in mice through AMPK-mediated NF-kappaB/NLRP3 signaling pathway).	Streptozocin	105-119	NLR family, pyrin domain containing 3	Mus musculus	160-165
34238903-0	2021	FUNDC1 Regulates Autophagy by Inhibiting ROS-NLRP3 Signaling to Avoid Apoptosis in the Lung In A Lipopolysaccharide-Induced Mouse Model.	ros	41-44	NLR family, pyrin domain containing 3	Mus musculus	45-50
34238903-4	2021	This study explored whether FUNDC1 regulates autophagy by inhibiting ROS-NLRP3 signaling to avoid apoptosis in the lung in a lipopolysaccharide-induced mouse model.	ros	69-72	NLR family, pyrin domain containing 3	Mus musculus	73-78
34776934-0	2021	The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome.	gliquidone	23-33	NLR family, pyrin domain containing 3	Mus musculus	129-134
34612661-0	2021	Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation.	Dextran Sulfate	35-57	NLR family, pyrin domain containing 3	Mus musculus	89-94
34612661-0	2021	Akkermansia muciniphila Alleviates Dextran Sulfate Sodium (DSS)-Induced Acute Colitis by NLRP3 Activation.	Dextran Sulfate	59-62	NLR family, pyrin domain containing 3	Mus musculus	89-94
34612661-14	2021	In conclusion, A. muciniphila alleviates DSS-induced acute colitis by NLRP3 activation, which enriches the mechanism and provides a new prospect for the probiotic-based treatment of colitis.	Dextran Sulfate	41-44	NLR family, pyrin domain containing 3	Mus musculus	70-75
34718231-6	2021	Treatment of pregnant mice with lipopolysaccharide (LPS) and RU38486 induced preterm birth (PTB) and also promoted uterine NLRP3 inflammasome and NF-kappaB activation.	Mifepristone	61-68	NLR family, pyrin domain containing 3	Mus musculus	123-128
34718231-7	2021	Treatment of pregnant mice with NLRP3 inflammasome inhibitor BAY11-7082 and MCC950 delayed the onset of labor and suppressed NLRP3 inflammasome and NF-kappaB activation in uterus.	3-(4-methylphenylsulfonyl)-2-propenenitrile	61-71	NLR family, pyrin domain containing 3	Mus musculus	32-37
34718231-7	2021	Treatment of pregnant mice with NLRP3 inflammasome inhibitor BAY11-7082 and MCC950 delayed the onset of labor and suppressed NLRP3 inflammasome and NF-kappaB activation in uterus.	3-(4-methylphenylsulfonyl)-2-propenenitrile	61-71	NLR family, pyrin domain containing 3	Mus musculus	125-130
34776934-5	2021	Importantly, gliquidone downregulated the LPS-induced microglial NLRP3 inflammasome and peripheral inflammation in wild-type mice.	gliquidone	13-23	NLR family, pyrin domain containing 3	Mus musculus	65-70
34776934-6	2021	An investigation of the molecular mechanism of the effects of gliquidone on LPS-stimulated proinflammatory responses showed that in BV2 microglial cells, gliquidone significantly decreased LPS-induced proinflammatory cytokine levels and inhibited ERK/STAT3/NF-kappaB phosphorylation by altering NLRP3 inflammasome activation.	gliquidone	62-72	NLR family, pyrin domain containing 3	Mus musculus	295-300
34776934-6	2021	An investigation of the molecular mechanism of the effects of gliquidone on LPS-stimulated proinflammatory responses showed that in BV2 microglial cells, gliquidone significantly decreased LPS-induced proinflammatory cytokine levels and inhibited ERK/STAT3/NF-kappaB phosphorylation by altering NLRP3 inflammasome activation.	gliquidone	154-164	NLR family, pyrin domain containing 3	Mus musculus	295-300
34776934-7	2021	In primary astrocytes, gliquidone selectively affected LPS-mediated proinflammatory cytokine expression and decreased STAT3/NF-kappaB signaling in an NLRP3-independent manner.	gliquidone	23-33	NLR family, pyrin domain containing 3	Mus musculus	150-155
34829577-8	2021	Further, reactive oxygen species (ROS) production was dependent on the S1P/S1P2 signaling axis in these cells, and the ROS generated regulate NLRP3 inflammasome activation, but not NLRP3 priming.	Reactive Oxygen Species	34-37	NLR family, pyrin domain containing 3	Mus musculus	142-147
34771569-7	2021	Treatment with TAK-242 also inhibited the activation of NLR family pyrin domain containing 3 (NLRP3) in UVB-exposed skin of SKH-1 mice.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	15-22	NLR family, pyrin domain containing 3	Mus musculus	56-92
34771569-7	2021	Treatment with TAK-242 also inhibited the activation of NLR family pyrin domain containing 3 (NLRP3) in UVB-exposed skin of SKH-1 mice.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	15-22	NLR family, pyrin domain containing 3	Mus musculus	94-99
34829577-2	2021	Here, we provide experimental evidence supporting the regulatory role of sphingosine-1-phosphate (S1P) in NLRP3 inflammasome activation in mouse bone-marrow-derived macrophages (BMDMs), along with the S1P receptor subtype involved and underlying regulatory mechanisms.	sphingosine 1-phosphate	73-96	NLR family, pyrin domain containing 3	Mus musculus	106-111
34829577-2	2021	Here, we provide experimental evidence supporting the regulatory role of sphingosine-1-phosphate (S1P) in NLRP3 inflammasome activation in mouse bone-marrow-derived macrophages (BMDMs), along with the S1P receptor subtype involved and underlying regulatory mechanisms.	sphingosine 1-phosphate	98-101	NLR family, pyrin domain containing 3	Mus musculus	106-111
34836115-12	2021	Moreover, GSH inhibited protein and mRNA expression of inflammasome-related protein including NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryoprin), ASC (Apoptosis-associated speck-like protein containing a CARD), and caspase-1.	Glutathione	10-13	NLR family, pyrin domain containing 3	Mus musculus	94-99
34836115-12	2021	Moreover, GSH inhibited protein and mRNA expression of inflammasome-related protein including NLRP3 (NOD-like receptor pyrin domain-containing protein 3, cryoprin), ASC (Apoptosis-associated speck-like protein containing a CARD), and caspase-1.	Glutathione	10-13	NLR family, pyrin domain containing 3	Mus musculus	101-152
34836115-13	2021	These findings provided evidence that GSH ameliorates renal injury including metabolic dysfunction and inflammation via the inhibition of NLRP3-dependent inflammasome in I/R-induced ARF mice.	Glutathione	38-41	NLR family, pyrin domain containing 3	Mus musculus	138-143
34829577-4	2021	In this event, S1P2, but not S1P1, was involved based on the attenuated NLRP3 upregulation with JTE013 (S1P2 antagonist) or S1P2 knockdown.	JTE 013	96-102	NLR family, pyrin domain containing 3	Mus musculus	72-77
34829577-8	2021	Further, reactive oxygen species (ROS) production was dependent on the S1P/S1P2 signaling axis in these cells, and the ROS generated regulate NLRP3 inflammasome activation, but not NLRP3 priming.	Reactive Oxygen Species	119-122	NLR family, pyrin domain containing 3	Mus musculus	142-147
34829577-8	2021	Further, reactive oxygen species (ROS) production was dependent on the S1P/S1P2 signaling axis in these cells, and the ROS generated regulate NLRP3 inflammasome activation, but not NLRP3 priming.	Reactive Oxygen Species	9-32	NLR family, pyrin domain containing 3	Mus musculus	142-147
34733156-9	2021	Our data also indicated that OT administration alleviated the expression of TLR4/My-D88 and the activation of NF-kappaB, NLRP3, and caspase-1 in lung tissues from the VILI mice model.	Oxytocin	29-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
34706239-6	2021	Mechanistically, Peli1 conjugates K63 ubiquitin chain to lysine 55 of the inflammasome adaptor apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which in turn facilitates ASC/NLRP3 interaction and ASC oligomerization, thereby contributing to inflammasome activation.	Lysine	57-63	NLR family, pyrin domain containing 3	Mus musculus	212-217
34734090-0	2021	Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways.	mangiferin	0-10	NLR family, pyrin domain containing 3	Mus musculus	76-81
34734090-6	2021	Furthermore, western blots, real-time PCR, and immunohistochemistry experiments confirmed that Man significantly activated the AMPK signal pathway and inhibited NLRP3 inflammasome activation and pyroptosis in NAFLD mice.	mangiferin	95-98	NLR family, pyrin domain containing 3	Mus musculus	161-166
34737695-12	2021	Collectively, the inhibition of mitochondrial ROS-mediated NLRP3 inflammasome activation contributes to the protective effects of CA, which may be considered a potential therapeutic agent for septic ALI.	ros	46-49	NLR family, pyrin domain containing 3	Mus musculus	59-64
34769018-7	2021	RESULTS: We revealed that NLRP3 inflammasomes are required for insulin-dependent glucose transport in the brain and memory consolidation.	Glucose	81-88	NLR family, pyrin domain containing 3	Mus musculus	26-31
34687223-4	2022	We showed that 5 mg/kg/day PFOS exposure may exacerbated liver inflammation and steatosis in high-fat diet (HFD)-fed mice with concurrently elevated expression of NLRP3 and caspase-1.	perfluorooctane sulfonic acid	27-31	NLR family, pyrin domain containing 3	Mus musculus	163-168
34737710-10	2021	Melatonin inhibited the activation of the NLRP3 inflammasome, thereby reducing the expression of IL-1beta and other related proinflammatory cytokines such as MCP-1, MIP-1, NLRP3, ASC, TNF-a and VEGF-A (all p < 0.05).	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	42-47
34737710-10	2021	Melatonin inhibited the activation of the NLRP3 inflammasome, thereby reducing the expression of IL-1beta and other related proinflammatory cytokines such as MCP-1, MIP-1, NLRP3, ASC, TNF-a and VEGF-A (all p < 0.05).	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	172-177
34733156-11	2021	Moreover, the OT administration may alleviate the activation of GSDMD partially through its effects on the NLRP3-mediated pathway.	Oxytocin	14-16	NLR family, pyrin domain containing 3	Mus musculus	107-112
34824899-8	2021	In summary, MPA reduces the level of demyelination and has an anti-inflammatory role in CNS demyelination by inducing M2 microglia polarization and suppressing the M1 phenotype through the inhibition of NF-kappaB and NLRP3 inflammasome.	Medroxyprogesterone Acetate	12-15	NLR family, pyrin domain containing 3	Mus musculus	217-222
34664134-4	2022	Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation.	Glyburide	19-32	NLR family, pyrin domain containing 3	Mus musculus	91-139
34664134-4	2022	Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation.	Glyburide	19-32	NLR family, pyrin domain containing 3	Mus musculus	141-146
34664134-4	2022	Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation.	Glyburide	34-37	NLR family, pyrin domain containing 3	Mus musculus	91-139
34664134-4	2022	Anti-diabetic drug glibenclamide (GLB) possesses anti-inflammatory properties and inhibits NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation.	Glyburide	34-37	NLR family, pyrin domain containing 3	Mus musculus	141-146
34664134-10	2022	In contrast, the clinical drug GLB and DMF have several other beneficial effects, which are independent of NLRP3 inhibition and Nrf2 activation.	Dimethyl Fumarate	39-42	NLR family, pyrin domain containing 3	Mus musculus	107-112
34664134-0	2022	Simultaneous Modulation of NLRP3 Inflammasome and Nrf2/ARE Pathway Rescues Thioacetamide-Induced Hepatic Damage in Mice: Role of Oxidative Stress and Inflammation.	Thioacetamide	75-88	NLR family, pyrin domain containing 3	Mus musculus	27-32
34652636-0	2022	MiR-124 Prevents the Microglial Proinflammatory Response by Inhibiting the Activities of TLR4 and Downstream NLRP3 in Palmitic Acid-Treated BV2 Cells.	Palmitic Acid	118-131	NLR family, pyrin domain containing 3	Mus musculus	109-114
34182382-8	2021	Pb increased the expression of NLRP3 and promoted cleavage of caspase-1 in mRNA and protein levels, and minocycline partially reversed the effects of Pb on NLRP3 inflammasomes.	Lead	0-2	NLR family, pyrin domain containing 3	Mus musculus	31-36
34652636-12	2022	Third, TAK-242 did not affect the expression of miR-124 but simulated the protective effect of the miR-124 mimic on microglial activation and NLRP3 expression.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	7-14	NLR family, pyrin domain containing 3	Mus musculus	142-147
34182382-8	2021	Pb increased the expression of NLRP3 and promoted cleavage of caspase-1 in mRNA and protein levels, and minocycline partially reversed the effects of Pb on NLRP3 inflammasomes.	Minocycline	104-115	NLR family, pyrin domain containing 3	Mus musculus	156-161
34182382-8	2021	Pb increased the expression of NLRP3 and promoted cleavage of caspase-1 in mRNA and protein levels, and minocycline partially reversed the effects of Pb on NLRP3 inflammasomes.	Lead	150-152	NLR family, pyrin domain containing 3	Mus musculus	156-161
34182382-9	2021	Blocking of NLRP3 by KO mice or siRNA attenuated neural alterations induced by Pb, weakened microglial activation in vivo and in vitro as well, without affecting the accumulation of Pb.	Lead	79-81	NLR family, pyrin domain containing 3	Mus musculus	12-17
34182382-10	2021	Pb increased autophagic protein levels and phosphorylation of NF-kappaB, while suppressing autophagy or NF-kappaB inhibited Pb"s effects on NLRP3.	Lead	124-126	NLR family, pyrin domain containing 3	Mus musculus	140-145
34182382-11	2021	CONCLUSIONS: NLRP3 is involved in the regulation of Pb-induced neurotoxicity.	Lead	52-54	NLR family, pyrin domain containing 3	Mus musculus	13-18
34507948-6	2021	NLRP3 inhibition by the selective inhibitor CRID3 sodium salt and NLRP3 deficiency improved the overall clearance of alpha-syn oligomers.	sodium salt	50-61	NLR family, pyrin domain containing 3	Mus musculus	0-5
34652636-3	2022	The aim of the study was to explore whether miR-124 exerted this effect through TLR4/MyD88/NF-kappaB p65/NLRP3 signaling in palmitic acid-treated BV2 cells.	Palmitic Acid	124-137	NLR family, pyrin domain containing 3	Mus musculus	105-110
34652636-9	2022	First, palmitic acid upregulated TLR4/MyD88/NF-kappaB p65 signaling, increased NLRP3 expression, elevated the pyroptosis rate, and promoted the microglial proinflammatory response in BV2 cells.	Palmitic Acid	7-20	NLR family, pyrin domain containing 3	Mus musculus	79-84
34652636-10	2022	Second, the miR-124 mimic and inhibitor separately alleviated and aggravated the effect of palmitic acid on microglial activation and NLRP3 expression.	Palmitic Acid	91-104	NLR family, pyrin domain containing 3	Mus musculus	134-139
34676022-9	2021	Next, cell experiments confirmed that CAY10602 inhibited activation of the NLRP3 inflammasome in BV2 microglial cells.	CAY10602	38-46	NLR family, pyrin domain containing 3	Mus musculus	75-80
34712137-9	2021	Moreover, PEA exerted a clear anti-inflammatory effect though ameliorating the expression of inflammatory mediators and suppressing the NLRP3 inflammasome pathway activation.	palmidrol	10-13	NLR family, pyrin domain containing 3	Mus musculus	136-141
34474083-5	2021	The blockage of N-methyl-d-aspartate receptors (NMDAR) by memantine reduced LPS-induced depression-like behaviors, NLRP3 inflammasome and astrocyte activation, and calpain-1 expression.	Memantine	58-67	NLR family, pyrin domain containing 3	Mus musculus	115-120
34721038-0	2021	Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo.	dhts	0-19	NLR family, pyrin domain containing 3	Mus musculus	42-47
34721038-3	2021	We found that dihydrotanshinone I (DHT) specifically blocked the canonical and non-canonical activation of the NLRP3 inflammasome.	dhts	14-33	NLR family, pyrin domain containing 3	Mus musculus	111-116
34721038-3	2021	We found that dihydrotanshinone I (DHT) specifically blocked the canonical and non-canonical activation of the NLRP3 inflammasome.	Dihydrotestosterone	35-38	NLR family, pyrin domain containing 3	Mus musculus	111-116
34721038-6	2021	We also discovered that DHT suppressed ASC oligomerization induced by NLRP3 agonists, suggesting that DHT inhibited the assembly of the NLRP3 inflammasome.	Dihydrotestosterone	24-27	NLR family, pyrin domain containing 3	Mus musculus	70-75
34721038-6	2021	We also discovered that DHT suppressed ASC oligomerization induced by NLRP3 agonists, suggesting that DHT inhibited the assembly of the NLRP3 inflammasome.	Dihydrotestosterone	24-27	NLR family, pyrin domain containing 3	Mus musculus	136-141
34721038-6	2021	We also discovered that DHT suppressed ASC oligomerization induced by NLRP3 agonists, suggesting that DHT inhibited the assembly of the NLRP3 inflammasome.	Dihydrotestosterone	102-105	NLR family, pyrin domain containing 3	Mus musculus	70-75
34721038-6	2021	We also discovered that DHT suppressed ASC oligomerization induced by NLRP3 agonists, suggesting that DHT inhibited the assembly of the NLRP3 inflammasome.	Dihydrotestosterone	102-105	NLR family, pyrin domain containing 3	Mus musculus	136-141
34721038-7	2021	Importantly, DHT possessed a significant therapeutic effect on NLRP3 inflammasome-mediated sepsis in mice.	Dihydrotestosterone	13-16	NLR family, pyrin domain containing 3	Mus musculus	63-68
34721038-8	2021	Therefore, our results aimed to clarify DHT as a specific small-molecule inhibitor for the NLRP3 inflammasome and suggested that DHT can be used as a potential drug against NLRP3-mediated diseases.	Dihydrotestosterone	40-43	NLR family, pyrin domain containing 3	Mus musculus	91-96
34721038-8	2021	Therefore, our results aimed to clarify DHT as a specific small-molecule inhibitor for the NLRP3 inflammasome and suggested that DHT can be used as a potential drug against NLRP3-mediated diseases.	Dihydrotestosterone	40-43	NLR family, pyrin domain containing 3	Mus musculus	173-178
34721038-8	2021	Therefore, our results aimed to clarify DHT as a specific small-molecule inhibitor for the NLRP3 inflammasome and suggested that DHT can be used as a potential drug against NLRP3-mediated diseases.	Dihydrotestosterone	129-132	NLR family, pyrin domain containing 3	Mus musculus	91-96
34721038-8	2021	Therefore, our results aimed to clarify DHT as a specific small-molecule inhibitor for the NLRP3 inflammasome and suggested that DHT can be used as a potential drug against NLRP3-mediated diseases.	Dihydrotestosterone	129-132	NLR family, pyrin domain containing 3	Mus musculus	173-178
34676022-12	2021	Taken together, CAY10602 alleviates TAA-induced HE by suppressing microglial activation and the NLRP3 inflammasome and reducing the neurotoxicity of NH4Cl in HT22 cells.	CAY10602	16-24	NLR family, pyrin domain containing 3	Mus musculus	96-101
34626306-0	2022	Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	98-103
34628369-0	2021	Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome.	schizandrin B	53-66	NLR family, pyrin domain containing 3	Mus musculus	157-162
34628369-6	2021	At the same time, Schisandrin B not only reduced inflammation in vivo and vitro model of colitis, but also suppressed the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome in vivo and vitro model of colitis.	schizandrin B	18-31	NLR family, pyrin domain containing 3	Mus musculus	216-221
34628369-8	2021	The inhibition of AMPK reduced the anti-inflammation effects of Schisandrin B on NLRP3 inflammasome.	schizandrin B	64-77	NLR family, pyrin domain containing 3	Mus musculus	81-86
34628369-10	2021	Collectively, our novel findings for first time showed that, Schisandrin B suppressed NLRP3 inflammasome activation-mediated interleukin-1beta (IL-1beta) level and pyroptosis in intestinal epithelial cells of colitis model through the activation of AMPK/Nrf2 dependent signaling-ROS-induced mitochondrial damage, which may be a significant therapeutic approach in the treatment of acute colitis.	schizandrin B	61-74	NLR family, pyrin domain containing 3	Mus musculus	86-91
34626306-7	2022	The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI.	CCI	134-137	NLR family, pyrin domain containing 3	Mus musculus	14-19
34628369-10	2021	Collectively, our novel findings for first time showed that, Schisandrin B suppressed NLRP3 inflammasome activation-mediated interleukin-1beta (IL-1beta) level and pyroptosis in intestinal epithelial cells of colitis model through the activation of AMPK/Nrf2 dependent signaling-ROS-induced mitochondrial damage, which may be a significant therapeutic approach in the treatment of acute colitis.	Reactive Oxygen Species	279-282	NLR family, pyrin domain containing 3	Mus musculus	86-91
34628484-9	2021	In addition, Metformin reversed mitophagy dysfunction and the over-expression of NLRP3.	Metformin	13-22	NLR family, pyrin domain containing 3	Mus musculus	81-86
34626306-9	2022	Moreover, SAL inhibited the activation of the TXNIP/NLRP3 inflammasome axis and mitigated the neuronal loss of spinal dorsal horn induced by nerve injury.	rhodioloside	10-13	NLR family, pyrin domain containing 3	Mus musculus	52-57
34619679-5	2022	We found that beta-TCP activates NLRP3 inflammasomes, and increases interleukin (IL)-1beta production in primary cultured mouse dendritic cells (DCs) and macrophages, and human THP-1 cells in caspase-1 dependent manner.	beta-tricalcium phosphate	14-22	NLR family, pyrin domain containing 3	Mus musculus	33-38
34619679-8	2022	Immune cell migration around subcutaneously injected beta-TCP particles was reduced in NLRP3-deficient mice.	beta-tricalcium phosphate	53-61	NLR family, pyrin domain containing 3	Mus musculus	87-92
34619679-9	2022	These findings suggest that the effects of beta-TCP particles in vivo are at least partly mediated by NLRP3 inflammasome complexes.	beta-tricalcium phosphate	43-51	NLR family, pyrin domain containing 3	Mus musculus	102-107
34384953-0	2021	AZD8055 ameliorates experimental autoimmune encephalomyelitis via the mTOR/ROS/NLRP3 pathway.	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	0-7	NLR family, pyrin domain containing 3	Mus musculus	79-84
34384953-0	2021	AZD8055 ameliorates experimental autoimmune encephalomyelitis via the mTOR/ROS/NLRP3 pathway.	ros	75-78	NLR family, pyrin domain containing 3	Mus musculus	79-84
34384953-10	2021	The degree of inflammatory cell infiltration and demyelination was mild in AZD8055-treated EAE model mice.Meanwhile, the pathway of ROS/NLRP3 was downregulated, and LC3 and NLRP3 were colocalized.	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	75-82	NLR family, pyrin domain containing 3	Mus musculus	136-141
34384953-10	2021	The degree of inflammatory cell infiltration and demyelination was mild in AZD8055-treated EAE model mice.Meanwhile, the pathway of ROS/NLRP3 was downregulated, and LC3 and NLRP3 were colocalized.	(5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol	75-82	NLR family, pyrin domain containing 3	Mus musculus	173-178
34612516-12	2022	iPSC-CM treatment attenuated NLRP3 expression and inhibited NLRP3 inflammasome activation by disrupting NLRP3-mediated ASC complex formation in LPS/IFN-gamma-primed RAW264.7 cells.	ipsc-cm	0-7	NLR family, pyrin domain containing 3	Mus musculus	29-34
34692767-12	2021	Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1beta, IL-18, p-YAP and p-LATS.	Folic Acid	0-10	NLR family, pyrin domain containing 3	Mus musculus	206-211
34612516-12	2022	iPSC-CM treatment attenuated NLRP3 expression and inhibited NLRP3 inflammasome activation by disrupting NLRP3-mediated ASC complex formation in LPS/IFN-gamma-primed RAW264.7 cells.	ipsc-cm	0-7	NLR family, pyrin domain containing 3	Mus musculus	60-65
34612516-12	2022	iPSC-CM treatment attenuated NLRP3 expression and inhibited NLRP3 inflammasome activation by disrupting NLRP3-mediated ASC complex formation in LPS/IFN-gamma-primed RAW264.7 cells.	ipsc-cm	0-7	NLR family, pyrin domain containing 3	Mus musculus	104-109
34118343-10	2021	Leojaponin inhibits NLRP3 inflammasome activation in both J774A.1 cells and bone marrow-derived macrophages in a dose dependent manner.	leojaponin	0-10	NLR family, pyrin domain containing 3	Mus musculus	20-25
34639115-2	2021	Recently, lysophosphatidic acid (LPA)/LPAR5 signaling has been reported to be involved in both NLRP3 inflammasome activation in macrophages and keratinocyte activation to produce inflammatory cytokines, contributing to psoriasis pathogenesis.	lysophosphatidic acid	10-31	NLR family, pyrin domain containing 3	Mus musculus	95-100
34639115-2	2021	Recently, lysophosphatidic acid (LPA)/LPAR5 signaling has been reported to be involved in both NLRP3 inflammasome activation in macrophages and keratinocyte activation to produce inflammatory cytokines, contributing to psoriasis pathogenesis.	lysophosphatidic acid	33-36	NLR family, pyrin domain containing 3	Mus musculus	95-100
34118343-14	2021	CONCLUSION: Our findings suggest that Leojaponin inhibits NLRP3 inflammasome activation through enhancing autophagy via RAPTOR phosphorylation, thereby highlighting Leojaponin as a potent drug for inflammasome-related diseases.	leojaponin	38-48	NLR family, pyrin domain containing 3	Mus musculus	58-63
34118343-14	2021	CONCLUSION: Our findings suggest that Leojaponin inhibits NLRP3 inflammasome activation through enhancing autophagy via RAPTOR phosphorylation, thereby highlighting Leojaponin as a potent drug for inflammasome-related diseases.	leojaponin	165-175	NLR family, pyrin domain containing 3	Mus musculus	58-63
34685620-8	2021	STZ-induced diabetic cardiomyopathy significantly increased inflammasome formation (TLR4, NLRP3, Nek7, and GBP5), pyroptosis markers (caspase-1, IL-1beta, and IL-18), inflammatory cytokines (IL-6 and TNF-alpha), MMP9, and infiltration of monocytes (CD14), macrophage (iNOS), and dendritic cells (CD11b and CD11c) (p < 0.05).	Streptozocin	0-3	NLR family, pyrin domain containing 3	Mus musculus	90-95
34382991-6	2021	Anserine alleviated hyperuricaemia and renal inflammation phenotypes, inhibited uric acid biosynthesis, promoted uric acid excretion, and inhibited NLRP3 inflammasome and TLR4/MyD88/NF-kappaB signalling pathway activation.	Anserine	0-8	NLR family, pyrin domain containing 3	Mus musculus	148-153
34473137-0	2021	Chlorogenic acid ameliorates Klebsiella pneumoniae-induced pneumonia in immunosuppressed mice via inhibiting the activation of NLRP3 inflammasomes.	Chlorogenic Acid	0-16	NLR family, pyrin domain containing 3	Mus musculus	127-132
34181898-5	2021	Dihydromyricetin (DMY), a potential compound to enhance SIRT3 expression, significantly inhibited cellular cholesterol accumulation, suppressed foam cell formation, improved mitochondrial function, attenuated oxidative stress, and alleviated NLRP3 activation in ox-LDL-stimulated macrophages.	dihydromyricetin	0-16	NLR family, pyrin domain containing 3	Mus musculus	242-247
34529881-9	2021	Cotreatment with AS1842856 or CQ all led to autophagic inhibition and thereby abolished Ang(1-7)-induced remission on NLRP3 inflammasome activation caused by LPS exposure, shifting the microglial polarization from M1 to M2 phenotype.	5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid	17-26	NLR family, pyrin domain containing 3	Mus musculus	118-123
34529881-9	2021	Cotreatment with AS1842856 or CQ all led to autophagic inhibition and thereby abolished Ang(1-7)-induced remission on NLRP3 inflammasome activation caused by LPS exposure, shifting the microglial polarization from M1 to M2 phenotype.	Chloroquine	30-32	NLR family, pyrin domain containing 3	Mus musculus	118-123
34181898-0	2021	Protective role of sirtuin3 against oxidative stress and NLRP3 inflammasome in cholesterol accumulation and foam cell formation of macrophages with ox-LDL-stimulation.	Cholesterol	79-90	NLR family, pyrin domain containing 3	Mus musculus	57-62
34181898-5	2021	Dihydromyricetin (DMY), a potential compound to enhance SIRT3 expression, significantly inhibited cellular cholesterol accumulation, suppressed foam cell formation, improved mitochondrial function, attenuated oxidative stress, and alleviated NLRP3 activation in ox-LDL-stimulated macrophages.	dihydromyricetin	18-21	NLR family, pyrin domain containing 3	Mus musculus	242-247
34271086-9	2021	Though the intracellular levels of pyroptosis-related cytokine caspase-1, cleaved caspase-1, NLRP3, IL-18, IL-1beta were upregulated both in MI and H2O2 stimulation, knockout of TN-C resisted such injury and alleviated cardiac pyroptosis, which further decreased IL-6, TNF-alpha, MCP-1 expression.	Hydrogen Peroxide	148-152	NLR family, pyrin domain containing 3	Mus musculus	93-98
34324866-7	2021	Particularly, the effect of SR9009 on inhibiting NLRP3-mediated IL-1beta and IL-18 production in macrophages was dependent on BMAL1 expression.	SR9009	28-34	NLR family, pyrin domain containing 3	Mus musculus	49-54
34271086-11	2021	And TLR4 inhibitor TAK-242 significantly reduced NLRP3 expression levels after MI.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	19-26	NLR family, pyrin domain containing 3	Mus musculus	49-54
34480147-1	2021	The nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain-containing 3 (NLRP3) inflammasome is essential in inflammation and inflammatory disorders.	Leucine	31-38	NLR family, pyrin domain containing 3	Mus musculus	97-102
34080091-2	2021	We previously reported that ALN augmented lipid A-induced interleukin (IL)-1beta production and NOD-like receptor pyrin domain-containing-3 (NLRP3)/apoptosis-associated speck-like protein containing a CARD (ASC)-dependent cell death.	Lipid A	42-49	NLR family, pyrin domain containing 3	Mus musculus	96-139
34480147-7	2021	Reactive oxygen species (ROS) upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.	Reactive Oxygen Species	0-23	NLR family, pyrin domain containing 3	Mus musculus	122-127
34480147-7	2021	Reactive oxygen species (ROS) upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.	Reactive Oxygen Species	25-28	NLR family, pyrin domain containing 3	Mus musculus	122-127
34480147-8	2021	Eliminating ROS suppressed NLRP3 activation and reduced sepsis and peritonitis symptoms in a MINK1-dependent manner.	Reactive Oxygen Species	12-15	NLR family, pyrin domain containing 3	Mus musculus	27-32
34685598-0	2021	Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner.	Bile Acids and Salts	0-10	NLR family, pyrin domain containing 3	Mus musculus	20-25
34685598-5	2021	LCA feeding led to strong liver damage and activation of NLRP3 inflammasome.	Lithocholic Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	57-62
34685598-9	2021	Primary HSC upregulated the NLRP3 inflammasome and early fibrotic markers when stimulated with DCA, but not LCA.	Dichloroacetic Acid	95-98	NLR family, pyrin domain containing 3	Mus musculus	28-33
34685598-11	2021	The data shows that distinct BA induce NLRP3 inflammasome activation in HSC or KC, promoting fibrosis or inflammation.	Bile Acids and Salts	29-31	NLR family, pyrin domain containing 3	Mus musculus	39-44
34080091-7	2021	Moreover, ALN induced the release of NLRP3 and ASC into culture supernatants.	Alendronate	10-13	NLR family, pyrin domain containing 3	Mus musculus	37-42
34080091-8	2021	GSK"872, but not Ac-IETD-CHO, reduced the ALN-induced release of NLRP3, but not ASC, into culture supernatants, and reduced ALN-induced cell death, but not ALN-induced LDH release.	Alendronate	42-45	NLR family, pyrin domain containing 3	Mus musculus	65-70
34080091-9	2021	Antibodies against NLRP3 and ASC upregulated caspase-11 expression in the cytosol by inhibiting ALN-induced cell death.	Alendronate	96-99	NLR family, pyrin domain containing 3	Mus musculus	19-24
34080091-2	2021	We previously reported that ALN augmented lipid A-induced interleukin (IL)-1beta production and NOD-like receptor pyrin domain-containing-3 (NLRP3)/apoptosis-associated speck-like protein containing a CARD (ASC)-dependent cell death.	Lipid A	42-49	NLR family, pyrin domain containing 3	Mus musculus	141-146
34298396-7	2021	Interestingly, JNK inhibitor SP600125 significantly attenuated surgery-induced cognitive impairments through inhibiting pyroptosis, inflammatory responses, and reducing immunoreactivity of NLRP3 and gasdermin D N terminus (GSDMD-N) in hippocampal microglia.	pyrazolanthrone	29-37	NLR family, pyrin domain containing 3	Mus musculus	189-194
34364304-8	2021	The results showed that CLP-induced pyroptosis was elevated, and CB2 agonist HU308 treatment inhibited the pyroptosis activity through a decrease of the protein levels of NLRP3 as well as caspase-1 and GSDMD activation.	HU 308	77-82	NLR family, pyrin domain containing 3	Mus musculus	171-176
34339962-7	2021	Moreover, Dioscin inhibited NF-kappaB, MAPK signaling and nucleotide oligomerization domain-like receptor family pyrin domain ontaining 3(NLRP3) inflammasome pathway in DSS-induced colitis.	dioscin	10-17	NLR family, pyrin domain containing 3	Mus musculus	138-143
34332342-8	2021	Interestingly, isoflurane preconditioning reduced intracellular Ca2+ levels, NF-kappaB translocation, and NLRP3 inflammasome activation in LPS-induced macrophages.	Isoflurane	15-25	NLR family, pyrin domain containing 3	Mus musculus	106-111
34333354-10	2021	Notably, markers related to ferroptosis including increased lipid peroxidation, enhanced neuroinflammation such as NLRP3, and also the expression of DMT1, ACSL4 and NCOA4, were reduced by TSG administration.	tsg	188-191	NLR family, pyrin domain containing 3	Mus musculus	115-120
34464722-7	2021	The two ERbeta agonists reversed LPS- and ATP-induced up-regulation of P2X7R and its downstream proteins, including NLRP3, ASC, caspase-1, and pro-IL-1beta, in RAW264.7 cells.	Adenosine Triphosphate	42-45	NLR family, pyrin domain containing 3	Mus musculus	116-121
34448620-2	2021	Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT), have been shown to block the NLRP3 inflammasome and prevent retinal degeneration in a mouse model of age-related macular degeneration.	Zidovudine	61-71	NLR family, pyrin domain containing 3	Mus musculus	108-113
34448620-2	2021	Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT), have been shown to block the NLRP3 inflammasome and prevent retinal degeneration in a mouse model of age-related macular degeneration.	Zidovudine	73-76	NLR family, pyrin domain containing 3	Mus musculus	108-113
34087492-0	2021	Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling.	bakuchiol	0-9	NLR family, pyrin domain containing 3	Mus musculus	73-78
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Mercury	17-19	NLR family, pyrin domain containing 3	Mus musculus	86-148
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Mercury	17-19	NLR family, pyrin domain containing 3	Mus musculus	150-155
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Oxygen	54-60	NLR family, pyrin domain containing 3	Mus musculus	86-148
34332282-13	2021	Mechanistically, HG stimulated mitochondrial reactive oxygen species (mtROS)-mediated NOD-like receptor family and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and EMT in tubular epithelial cells, and andrographolide (5 and 10 muM) inhibited these effects by ameliorating mitochondrial dysfunction.	Oxygen	54-60	NLR family, pyrin domain containing 3	Mus musculus	150-155
34332282-14	2021	In vivo, treatment with andrographolide (2 and 4 mg/kg) inhibited renal tubular cell apoptosis, EMT and tubulointerstitial fibrosis, mitochondrial dysfunction and NLRP3 inflammasome activation in diabetic mice.	andrographolide	24-39	NLR family, pyrin domain containing 3	Mus musculus	163-168
34332282-15	2021	CONCLUSION: Andrographolide (5 and 10 muM) prevents HG-induced renal tubular cell damage, and andrographolide (2 and 4 mg/kg) protects against the progression of diabetic tubular injury and fibrosis in mice by suppressing mitochondrial dysfunction and NLRP3 inflammasome activation.	andrographolide	12-27	NLR family, pyrin domain containing 3	Mus musculus	252-257
34332282-15	2021	CONCLUSION: Andrographolide (5 and 10 muM) prevents HG-induced renal tubular cell damage, and andrographolide (2 and 4 mg/kg) protects against the progression of diabetic tubular injury and fibrosis in mice by suppressing mitochondrial dysfunction and NLRP3 inflammasome activation.	andrographolide	94-109	NLR family, pyrin domain containing 3	Mus musculus	252-257
34087492-8	2021	BAK also reduced the expressions of NLRP3, ASC, cleaved-caspase-1, IL-1beta and IL-18.	bakuchiol	0-3	NLR family, pyrin domain containing 3	Mus musculus	36-41
34087492-11	2021	It was found that the functions of BAK in vitro were consistent with those in vivo, as manifested by reduced NLRP3 inflammasome and activated Nrf2 signaling.	bakuchiol	35-38	NLR family, pyrin domain containing 3	Mus musculus	109-114
34087492-14	2021	In short, BAK is more meaningful in improving cerebral ischemic injury through suppressing NLRP3-mediated inflammatory response and activating the Nrf2 signaling pathway.	bakuchiol	10-13	NLR family, pyrin domain containing 3	Mus musculus	91-96
34391754-0	2021	Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice.	andrographolide sulfonate	83-108	NLR family, pyrin domain containing 3	Mus musculus	14-19
34391754-6	2021	Finally, we verified that 5-FU significantly activated the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in myeloid-derived suppressor cells (MDSCs) and that andrographolide sulfonate reversed this process to sensitize cells to 5-FU.	Fluorouracil	26-30	NLR family, pyrin domain containing 3	Mus musculus	59-95
34391754-6	2021	Finally, we verified that 5-FU significantly activated the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in myeloid-derived suppressor cells (MDSCs) and that andrographolide sulfonate reversed this process to sensitize cells to 5-FU.	Fluorouracil	26-30	NLR family, pyrin domain containing 3	Mus musculus	97-102
34391754-6	2021	Finally, we verified that 5-FU significantly activated the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in myeloid-derived suppressor cells (MDSCs) and that andrographolide sulfonate reversed this process to sensitize cells to 5-FU.	andrographolide sulfonate	170-195	NLR family, pyrin domain containing 3	Mus musculus	59-95
34391754-6	2021	Finally, we verified that 5-FU significantly activated the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in myeloid-derived suppressor cells (MDSCs) and that andrographolide sulfonate reversed this process to sensitize cells to 5-FU.	andrographolide sulfonate	170-195	NLR family, pyrin domain containing 3	Mus musculus	97-102
34630845-0	2021	Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF-kappaB Suppression and NLRP3 Inflammasome Inhibition.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	143-148
34391754-7	2021	In summary, andrographolide sulfonate synergistically enhanced antitumor effects and improved antitumor immunity by inhibiting 5-FU-induced NLRP3 activation in MDSCs.	andrographolide sulfonate	12-37	NLR family, pyrin domain containing 3	Mus musculus	140-145
34391754-7	2021	In summary, andrographolide sulfonate synergistically enhanced antitumor effects and improved antitumor immunity by inhibiting 5-FU-induced NLRP3 activation in MDSCs.	Fluorouracil	127-131	NLR family, pyrin domain containing 3	Mus musculus	140-145
34411834-0	2021	Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway.	magnolol	0-8	NLR family, pyrin domain containing 3	Mus musculus	131-136
34638977-0	2021	Donepezil Regulates LPS and Abeta-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.	Donepezil	0-9	NLR family, pyrin domain containing 3	Mus musculus	76-81
34638977-5	2021	Importantly, we found that donepezil suppressed LPS-induced AKT/MAPK signaling, the NLRP3 inflammasome, and transcription factor NF-kB/STAT3 phosphorylation to reduce neuroinflammatory responses.	Donepezil	27-36	NLR family, pyrin domain containing 3	Mus musculus	84-89
34630845-8	2021	Western blot revealed a decrease in pyroptosis-related proteins, e.g., GSDMD-N, cleaved caspase-1, NLRP3, IL-1beta, and IL-18, following in vitro or in vivo curcumin treatment.	Curcumin	157-165	NLR family, pyrin domain containing 3	Mus musculus	99-104
34630845-10	2021	NLRP3 knocked down by siRNA transfection markedly increased the inhibitory effects of curcumin on microglial pyroptosis and proinflammatory responses, both in vitro and in vivo.	Curcumin	86-94	NLR family, pyrin domain containing 3	Mus musculus	0-5
34630845-11	2021	Furthermore, stereotaxic microinjection of AAV-based NLRP3 shRNA significantly improved sensorimotor function and reduced WM lesion following curcumin treatment in MCAO mice.	CHEMBL2031461	43-46	NLR family, pyrin domain containing 3	Mus musculus	53-58
34630845-11	2021	Furthermore, stereotaxic microinjection of AAV-based NLRP3 shRNA significantly improved sensorimotor function and reduced WM lesion following curcumin treatment in MCAO mice.	Curcumin	142-150	NLR family, pyrin domain containing 3	Mus musculus	53-58
34630845-12	2021	Our study suggested that curcumin reduced stroke-induced WM damage, improved functional outcomes, and attenuated microglial pyroptosis, at least partially, through suppression of the NF-kappaB/NLRP3 signaling pathway, further supporting curcumin as a potential therapeutic drug for stroke.	Curcumin	25-33	NLR family, pyrin domain containing 3	Mus musculus	193-198
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	NLR family, pyrin domain containing 3	Mus musculus	140-145
34659244-7	2021	Indeed, valinomycin-induced compulsory mitochondrial depolarization in neutrophils restored inflammasome-dependent cell death and ATP-induced NLRP3 desensitization in neutrophils.	Valinomycin	8-19	NLR family, pyrin domain containing 3	Mus musculus	142-147
34659244-7	2021	Indeed, valinomycin-induced compulsory mitochondrial depolarization in neutrophils restored inflammasome-dependent cell death and ATP-induced NLRP3 desensitization in neutrophils.	Adenosine Triphosphate	130-133	NLR family, pyrin domain containing 3	Mus musculus	142-147
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	NLR family, pyrin domain containing 3	Mus musculus	195-200
34684415-8	2021	The PM2.5 exposure was involved in airway remodeling and inflammation, suggesting that YG-1 treatment improves acute bronchial and pulmonary inflammation by inhibiting the inflammatory cytokines (NLRP3/caspase-1 pathway).	YG-1	87-91	NLR family, pyrin domain containing 3	Mus musculus	196-201
34552216-10	2021	Furthermore, DHC decreased lipopolysaccharide (LPS)-induced inflammation in BMDMs, as evidenced by the reduced protein levels of CD80, iNOS, NLRP3, IL-1beta, and IL-18.	dehydrocorydalin	13-16	NLR family, pyrin domain containing 3	Mus musculus	141-146
34506712-0	2021	Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis.	pterostilbene	19-32	NLR family, pyrin domain containing 3	Mus musculus	79-84
34369953-0	2021	Correction: Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice.	ethyl acetate	80-93	NLR family, pyrin domain containing 3	Mus musculus	26-31
34369953-1	2021	Correction for "Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of Bungeanum ameliorated cognitive dysfunction in aged mice" by Meihuan Zhao et al., Food Funct., 2021, DOI: 10.1039/D1FO00876E.	ethyl acetate	84-97	NLR family, pyrin domain containing 3	Mus musculus	30-35
34683104-0	2021	NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice.	Cocaine	34-41	NLR family, pyrin domain containing 3	Mus musculus	0-5
34630100-7	2021	CBD treatment inhibited macrophage recruitment and suppressed activation of NFkappaB-NLRP3-pyroptosis pathway in mice livers.	Cannabidiol	0-3	NLR family, pyrin domain containing 3	Mus musculus	85-90
34572437-0	2021	The AST-120 Recovers Uremic Toxin-Induced Cognitive Deficit via NLRP3 Inflammasome Pathway in Astrocytes and Microglia.	AST 120	4-11	NLR family, pyrin domain containing 3	Mus musculus	64-69
34567409-12	2021	NR treatment also reduced levels of the inflammatory cytokines, IL-1beta and TNF-alpha, and attenuated activation of NLRP3 inflammasomes induced by TAC.	nicotinamide-beta-riboside	0-2	NLR family, pyrin domain containing 3	Mus musculus	117-122
34146983-11	2021	Targeting the inhibition of NLRP3-mediated macrophage pyroptosis provides a new way to study lung injury induced by the exposure to PM2.5.	[4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE	132-135	NLR family, pyrin domain containing 3	Mus musculus	28-33
34192596-0	2021	Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice.	demethylenetetrahydroberberine	0-30	NLR family, pyrin domain containing 3	Mus musculus	93-98
34192596-8	2021	Moreover, pull-down assays and compound-centric chemical proteomics illustrated that DMTHB inhibited NOD-like receptor protein 3 (NLRP3) inflammasome signaling.	dmthb	85-90	NLR family, pyrin domain containing 3	Mus musculus	101-128
34192596-8	2021	Moreover, pull-down assays and compound-centric chemical proteomics illustrated that DMTHB inhibited NOD-like receptor protein 3 (NLRP3) inflammasome signaling.	dmthb	85-90	NLR family, pyrin domain containing 3	Mus musculus	130-135
34192596-11	2021	SIGNIFICANCE: DMTHB targeted the NLRP3 inflammasome to suppress inflammation and inhibited CYP2E1 to reduce oxidative stress and ER stress.	dmthb	14-19	NLR family, pyrin domain containing 3	Mus musculus	33-38
34526512-5	2021	Paradoxically, a consequence of CT135 mediated neutrophil killing results in a submucosal macrophage-associated endometritis driven by ATP/P2X7R induced NLRP3 inflammasome activation.	Adenosine Triphosphate	135-138	NLR family, pyrin domain containing 3	Mus musculus	153-158
34526512-5	2021	Paradoxically, a consequence of CT135 mediated neutrophil killing results in a submucosal macrophage-associated endometritis driven by ATP/P2X7R induced NLRP3 inflammasome activation.	p2x7r	139-144	NLR family, pyrin domain containing 3	Mus musculus	153-158
34526512-8	2021	We propose this source of ATP serves as a DAMP to activate submucosal macrophage NLRP3 inflammasome that drive damaging immunopathology.	Adenosine Triphosphate	26-29	NLR family, pyrin domain containing 3	Mus musculus	81-86
34526512-8	2021	We propose this source of ATP serves as a DAMP to activate submucosal macrophage NLRP3 inflammasome that drive damaging immunopathology.	dinitrophenyl-aminopropyl-methylamine	42-46	NLR family, pyrin domain containing 3	Mus musculus	81-86
34567409-12	2021	NR treatment also reduced levels of the inflammatory cytokines, IL-1beta and TNF-alpha, and attenuated activation of NLRP3 inflammasomes induced by TAC.	tac	148-151	NLR family, pyrin domain containing 3	Mus musculus	117-122
34567409-16	2021	Mechanically, these beneficial effects were attributed to the inhibition of NLRP3 inflammasome activation and myocardial inflammatory response by regulating the NAD+-Sirtuin3-MnSOD signaling pathway.	NAD	161-165	NLR family, pyrin domain containing 3	Mus musculus	76-81
34566976-0	2021	Oridonin Prolongs the Survival of Mouse Cardiac Allografts by Attenuating the NF-kappaB/NLRP3 Pathway.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	88-93
34497121-6	2021	NR treatment also reduced NLRP3 inflammasome expression, DNA damage, apoptosis, and cellular senescence in the AD mouse brains.	nicotinamide-beta-riboside	0-2	NLR family, pyrin domain containing 3	Mus musculus	26-31
34566976-1	2021	Background: Oridonin (Ori), the main bioactive ingredient of the natural anti-inflammatory herb Rabdosia rubescens, could be a covalent inhibitor of the NLRP3 inflammasome.	oridonin	12-20	NLR family, pyrin domain containing 3	Mus musculus	153-158
34566976-15	2021	Ori could exert IS activity through decreasing IL-1beta and IL-18 production and Th1 differentiation and proliferation and expanding Tregs via inhibiting the NF-kappaB/NLRP3 signaling pathway.	tregs	133-138	NLR family, pyrin domain containing 3	Mus musculus	168-173
34646372-1	2021	Aberrant activation of the nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome drives the development of many complex inflammatory diseases, such as obesity, Alzheimer"s disease, and atherosclerosis.	Leucine	57-64	NLR family, pyrin domain containing 3	Mus musculus	126-131
34506597-6	2021	24 hours following the final injury, rmTBI causes an upregulation in mRNA levels of NLRP3, caspase-1, the apoptosis-associated speck-like protein containing a CARD (ASC), nuclear factor kappa B (NF-kappaB), interleukin-1Beta (IL-1beta), interleukin 18 (IL-18), nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase 1 (HMOX1).	rmtbi	37-42	NLR family, pyrin domain containing 3	Mus musculus	84-89
34506597-11	2021	These results suggest that NLRP3 inflammasome activation and the subsequent inflammatory response in the mice cortex are involved in the process of rmTBI.	rmtbi	148-153	NLR family, pyrin domain containing 3	Mus musculus	27-32
34491906-10	2021	The co-culture of DNTs and intestinal macrophages showed that DNTs could activate Fas/FasL-TNF-alpha signal and induce the activation of NLRP3 inflammasome.	2,6-dinitrotoluene	62-66	NLR family, pyrin domain containing 3	Mus musculus	137-142
34567414-0	2021	Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression.	polymethoxyflavones	0-19	NLR family, pyrin domain containing 3	Mus musculus	124-129
34646372-10	2021	Local administration of GC-VLNs in mice alleviates NLRP3 inflammasome-mediated inflammation in chemical-induced acute liver injury.	gc-vlns	24-31	NLR family, pyrin domain containing 3	Mus musculus	51-56
34646372-12	2021	The phospholipid 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) in GC-VLNs has been identified to inhibit NLRP3 inflammasome activation.	Phospholipids	4-16	NLR family, pyrin domain containing 3	Mus musculus	110-115
34646372-12	2021	The phospholipid 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) in GC-VLNs has been identified to inhibit NLRP3 inflammasome activation.	1,2-DILINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	17-60	NLR family, pyrin domain containing 3	Mus musculus	110-115
34571975-0	2021	Sinapic Acid Controls Inflammation by Suppressing NLRP3 Inflammasome Activation.	sinapinic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	50-55
34646372-12	2021	The phospholipid 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) in GC-VLNs has been identified to inhibit NLRP3 inflammasome activation.	1,2-Dilauroyl-sn-glycero-3-phosphocholine	62-66	NLR family, pyrin domain containing 3	Mus musculus	110-115
34342641-5	2021	In macrophages expressing ASCC171A, a mutant ASC without glutathionylation site, activation of NLRP3 inflammasome is GSTO1 independent, ROS independent, and signal 2 less dependent.	ros	136-139	NLR family, pyrin domain containing 3	Mus musculus	95-100
34512861-0	2021	XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis-Induced Renal Inflammation and Oxidative Injury via the miR-223/NLRP3 Pathway.	Calcium Oxalate	27-42	NLR family, pyrin domain containing 3	Mus musculus	124-129
34564408-6	2021	SP challenge caused a significant concentration-dependent increase in proinflammatory markers (TLR4, p-p38 MAPK, NF-kappaB) paralleled to a marked upregulation of inflammasome-dependent inflammatory pathways (NLRP3, Caspase-1) with IL-6, IL-1beta, TNF-alpha over-release, compared to vehicle group.	sp	0-2	NLR family, pyrin domain containing 3	Mus musculus	209-214
34564408-9	2021	Our data show for the first time that um-PEA, via PPAR-alpha, markedly inhibits the SP induced NLRP3 signalling pathway outlining a novel mechanism of action of this lipid against COVID-19.	sp	84-86	NLR family, pyrin domain containing 3	Mus musculus	95-100
34512861-7	2021	The XIST, NLRP3, caspase-1, and IL-1beta levels were notably increased in kidney samples from glyoxylate-induced CaOx stone model mice.	glyoxylic acid	94-104	NLR family, pyrin domain containing 3	Mus musculus	10-15
34512861-11	2021	Our results suggest that the lncRNA XIST participates in the formation and progression of renal calculus by interacting with miR-223-3p and the NLRP3/Caspase-1/IL-1beta pathway to mediate the inflammatory response and ROS production.	Reactive Oxygen Species	218-221	NLR family, pyrin domain containing 3	Mus musculus	144-149
34224819-0	2021	Treadmill exercise alleviates neuronal damage by suppressing NLRP3 inflammasome and microglial activation in the MPTP mouse model of Parkinson"s disease.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	113-117	NLR family, pyrin domain containing 3	Mus musculus	61-66
34224819-4	2021	In this study, we investigated whether NLRP3 inflammasome was involved in treadmill exercise-induced neuroprotection and anti-inflammation effect in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	153-197	NLR family, pyrin domain containing 3	Mus musculus	39-44
34224819-4	2021	In this study, we investigated whether NLRP3 inflammasome was involved in treadmill exercise-induced neuroprotection and anti-inflammation effect in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	199-203	NLR family, pyrin domain containing 3	Mus musculus	39-44
34224819-11	2021	Overall, our study demonstrated that treadmill exercise could effectively alleviates neuronal damage via inhibition of NLRP3 inflammasome and microglial activation in MPTP-induced PD mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	167-171	NLR family, pyrin domain containing 3	Mus musculus	119-124
34405489-0	2021	Sodium houttuyfonate attenuates neurological defects after traumatic brain injury in mice via inhibiting NLRP3 inflammasomes.	sodium houttuyfonate	0-20	NLR family, pyrin domain containing 3	Mus musculus	105-110
34285037-0	2021	Over-production of gastrointestinal 5-HT promotes colitis-associated colorectal cancer progression via enhancing NLRP3 inflammasome activation.	Serotonin	36-40	NLR family, pyrin domain containing 3	Mus musculus	113-118
34285037-7	2021	NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling.	Serotonin	72-76	NLR family, pyrin domain containing 3	Mus musculus	0-5
34285037-7	2021	NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling.	Serotonin	72-76	NLR family, pyrin domain containing 3	Mus musculus	187-192
34285037-7	2021	NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling.	Serotonin	178-182	NLR family, pyrin domain containing 3	Mus musculus	0-5
34285037-7	2021	NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling.	Serotonin	178-182	NLR family, pyrin domain containing 3	Mus musculus	187-192
34285037-9	2021	Addressing the positive feedback loop between 5-HT and NLRP3 signaling could provide potential therapeutic targets for CRC.	Serotonin	46-50	NLR family, pyrin domain containing 3	Mus musculus	55-60
34173703-9	2021	Mechanistically, PM2.5 activated the NLRP3 inflammasome in HUVECs while knockdown of NLRP3 could effectively reverse the downregulation of eNOS expression and production of ROS after PM2.5 exposure.	Reactive Oxygen Species	173-176	NLR family, pyrin domain containing 3	Mus musculus	37-42
34173703-9	2021	Mechanistically, PM2.5 activated the NLRP3 inflammasome in HUVECs while knockdown of NLRP3 could effectively reverse the downregulation of eNOS expression and production of ROS after PM2.5 exposure.	Reactive Oxygen Species	173-176	NLR family, pyrin domain containing 3	Mus musculus	85-90
34405489-6	2021	The results showed that SH inhibited TLR4 and NLRP3 inflammasome activation in the microglia cell.	sodium houttuyfonate	24-26	NLR family, pyrin domain containing 3	Mus musculus	46-51
34129896-0	2021	Saponins from Panax japonicus alleviate HFD-induced impaired behaviors through inhibiting NLRP3 inflammasome to upregulate AMPA receptors.	Saponins	0-8	NLR family, pyrin domain containing 3	Mus musculus	90-95
34512865-0	2021	Melatonin Exerts Cardioprotective Effects by Inhibiting NLRP3 Inflammasome-Induced Pyroptosis in Mice following Myocardial Infarction.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	56-61
34512865-6	2021	The results also showed that pyroptosis was induced both in vivo and in vitro, as evidenced by increased NLRP3, cleaved caspase-1, GSDMD-N, and mature IL-1beta and IL-18 levels, and these changes were decreased by melatonin treatment.	Melatonin	214-223	NLR family, pyrin domain containing 3	Mus musculus	105-110
34512865-9	2021	Our results indicate that melatonin can exert cardioprotective effects by inhibiting NLRP3 inflammasome-induced pyroptosis through modulation of the TLR4/NF-kappaB signaling pathway and provide strong evidence for the utility of melatonin in the treatment of MI.	Melatonin	26-35	NLR family, pyrin domain containing 3	Mus musculus	85-90
34512865-9	2021	Our results indicate that melatonin can exert cardioprotective effects by inhibiting NLRP3 inflammasome-induced pyroptosis through modulation of the TLR4/NF-kappaB signaling pathway and provide strong evidence for the utility of melatonin in the treatment of MI.	Melatonin	229-238	NLR family, pyrin domain containing 3	Mus musculus	85-90
34119876-4	2021	In the present study, we found that inhibition of SAHH by using its inhibitor adenosine dialdehyde (ADA) accumulates intracellular or plasma SAH levels and increases high glucose-induced podocyte injury and aggravates STZ-induced diabetic nephropathy, which is associated with Nod-like receptor protein 3 (NLRP3) inflammasome activation.	Adenosine	78-87	NLR family, pyrin domain containing 3	Mus musculus	277-304
34119876-4	2021	In the present study, we found that inhibition of SAHH by using its inhibitor adenosine dialdehyde (ADA) accumulates intracellular or plasma SAH levels and increases high glucose-induced podocyte injury and aggravates STZ-induced diabetic nephropathy, which is associated with Nod-like receptor protein 3 (NLRP3) inflammasome activation.	periodate-oxidized adenosine	100-103	NLR family, pyrin domain containing 3	Mus musculus	277-304
34416350-0	2021	Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.	microcystin	14-25	NLR family, pyrin domain containing 3	Mus musculus	157-162
34573030-8	2021	However, mitoTA293 suppressed the induction of mitophagy, enhanced the activation of the NLRP3 inflammasome/caspase-1/IL1beta/IL1R/p-p38 MAPK/p16 and p21 pathways, and exacerbated cellular senescence, inflammation, and fibrosis.	mitota293	9-18	NLR family, pyrin domain containing 3	Mus musculus	89-94
34450210-8	2021	We further confirmed that SAL inhibited furan-induced inflammation by reducing the levels of NLRP3, ASC, Cleaved Caspase-1 and IL-1beta and decreasing the production of pro-inflammatory cytokines.	rhodioloside	26-29	NLR family, pyrin domain containing 3	Mus musculus	93-98
34450210-8	2021	We further confirmed that SAL inhibited furan-induced inflammation by reducing the levels of NLRP3, ASC, Cleaved Caspase-1 and IL-1beta and decreasing the production of pro-inflammatory cytokines.	furan	40-45	NLR family, pyrin domain containing 3	Mus musculus	93-98
34450210-9	2021	Our results shed light into the alleviating mechanisms behind furan-induced liver inflammation, and suggested that SAL inhibited OS, ERS and related MAPK and NF-kappaB pathways and therefore inhibited the NLRP3 inflammasome activation, which may be its potential mechanism of alleviating liver inflammation.	furan	62-67	NLR family, pyrin domain containing 3	Mus musculus	205-210
34450210-9	2021	Our results shed light into the alleviating mechanisms behind furan-induced liver inflammation, and suggested that SAL inhibited OS, ERS and related MAPK and NF-kappaB pathways and therefore inhibited the NLRP3 inflammasome activation, which may be its potential mechanism of alleviating liver inflammation.	rhodioloside	115-118	NLR family, pyrin domain containing 3	Mus musculus	205-210
34504642-9	2021	The levels of NLRP3 inflammasome proteins, including NLRP3, ASC, caspase-1, and cleaved caspase-1 were decreased in the YSPDF-treated group.	yspdf	120-125	NLR family, pyrin domain containing 3	Mus musculus	14-19
34581089-10	2021	These aforementioned results suggest that the total triterpenoids from C. speciosa have significant protective effects against CAG induced by Hp, and its mechanism may be related to enhancing the function of endogenous antioxidant system, suppressing the oxidative stress and inflammatory reaction induced by Hp, correcting lysosomal dysfunction and inflammatory activation of TLR4/NF-kappaB/NLRP3 inflammasome signaling pathway and thus inhibiting mitochondria-mediated apoptosis.	Triterpenes	52-65	NLR family, pyrin domain containing 3	Mus musculus	392-397
34511904-9	2021	Mechanistic studies demonstrated that the elemene nanoemulsion effectively scavenged the reactive oxygen species (ROS) in vitro and in vivo, which decreased the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently reduced angiogenesis in the tumor microenvironment as well as decreased the level of NLRP3 inflammasomes and IL-1beta production.	elemene	42-49	NLR family, pyrin domain containing 3	Mus musculus	325-330
34511904-9	2021	Mechanistic studies demonstrated that the elemene nanoemulsion effectively scavenged the reactive oxygen species (ROS) in vitro and in vivo, which decreased the stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently reduced angiogenesis in the tumor microenvironment as well as decreased the level of NLRP3 inflammasomes and IL-1beta production.	Reactive Oxygen Species	114-117	NLR family, pyrin domain containing 3	Mus musculus	325-330
34131970-0	2021	Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation.	Emodin	0-6	NLR family, pyrin domain containing 3	Mus musculus	70-75
34131970-8	2021	In vitro, emodin alleviated LPS-induced cell injury and inflammation in cardiomyocytes by inhibiting NLRP3 inflammasome activation.	Emodin	10-16	NLR family, pyrin domain containing 3	Mus musculus	101-106
34131970-10	2021	Taken together, our findings suggest that emodin improves LPS-induced myocardial injury and cardiac dysfunction by alleviating the inflammatory response and cardiomyocyte pyroptosis by inhibiting NLRP3 inflammasome activation, which provides a feasible strategy for preventing and treating myocardial injury in sepsis.	Emodin	42-48	NLR family, pyrin domain containing 3	Mus musculus	196-201
34531748-8	2021	In addition, Nrf2 deficiency strikingly weakens the beneficial effects of AICAR on alleviation of liver injury, oxidative stress and NLRP3 inflammasome activation in L-arginine-induced PALI mice.	AICA ribonucleotide	74-79	NLR family, pyrin domain containing 3	Mus musculus	133-138
34531748-9	2021	Thus, AICAR protects against PALI in rodents by triggering AMPK, which is mediated at least in part by Nrf2-modulated antioxidant effects and NLRP3 inflammasome activation.	AICA ribonucleotide	6-11	NLR family, pyrin domain containing 3	Mus musculus	142-147
34504642-9	2021	The levels of NLRP3 inflammasome proteins, including NLRP3, ASC, caspase-1, and cleaved caspase-1 were decreased in the YSPDF-treated group.	yspdf	120-125	NLR family, pyrin domain containing 3	Mus musculus	53-58
34504642-10	2021	Cell experiments showed that YSPDF inhibited EMT and the NLRP3 inflammasome in HG-exposed HK-2 cells, possibly via activation of Nrf2.	yspdf	29-34	NLR family, pyrin domain containing 3	Mus musculus	57-62
34577821-0	2021	Ameliorative Effects of Cardamonin on Monosodium Urate-Induced Gouty Arthritis through Inhibiting NLRP3 Inflammasome Mediation.	cardamonin	24-34	NLR family, pyrin domain containing 3	Mus musculus	98-103
34577821-7	2021	Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion.	Uric Acid	90-93	NLR family, pyrin domain containing 3	Mus musculus	55-60
34577821-7	2021	Results: In the current study, we determined that most NLRP3 was released passively after MSU stimulation, and this release of NLRP3 promoted caspase-1 activation and IL-1beta secretion.	Uric Acid	90-93	NLR family, pyrin domain containing 3	Mus musculus	127-132
34462641-0	2021	Quyu Shengxin Decoction Alleviates DSS-Induced Ulcerative Colitis in Mice by Suppressing RIP1/RIP3/NLRP3 Signalling.	shengxin	5-13	NLR family, pyrin domain containing 3	Mus musculus	99-104
34417574-0	2022	Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflammasome activation in lung macrophages.	tetrandrine	0-11	NLR family, pyrin domain containing 3	Mus musculus	75-80
34417574-7	2022	Specifically, we found that tetrandrine attenuated silicosis by inhibiting both the canonical and non-canonical NLRP3 inflammasome pathways in lung macrophages.	tetrandrine	28-39	NLR family, pyrin domain containing 3	Mus musculus	112-117
34378931-4	2021	Moreover, the activation of the NOD-like receptor (NLR) family member NLRP3 inflammasome-mediated inflammation was significantly inhibited by both alpha-GOS and beta-GOS.	alpha-gos	147-156	NLR family, pyrin domain containing 3	Mus musculus	70-75
34378931-4	2021	Moreover, the activation of the NOD-like receptor (NLR) family member NLRP3 inflammasome-mediated inflammation was significantly inhibited by both alpha-GOS and beta-GOS.	beta-gos	161-169	NLR family, pyrin domain containing 3	Mus musculus	70-75
34433035-3	2021	Here, we show that deficiency of HIF-2alpha in macrophages results in excessive activation of the NLRP3 inflammasome in a manner dependent on CPT1A-mediated enhancement of fatty acid oxidation (FAO).	Fatty Acids	172-182	NLR family, pyrin domain containing 3	Mus musculus	98-103
34182071-0	2021	Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice.	Dehydroepiandrosterone	0-22	NLR family, pyrin domain containing 3	Mus musculus	104-109
34182071-4	2021	Furthermore, DHEA blocked the p38-induced NLRP3 inflammasome activation in both LPS-stimulated colon epithelial cells and macrophages.	Dehydroepiandrosterone	13-17	NLR family, pyrin domain containing 3	Mus musculus	42-47
34456729-10	2021	ABPPk inhibited the activation of microglia in hippocampal CA3 region and suppressed the activation of NF-kappaB as well as the expression of NLRP3, cleaved caspase-1, and ASC in the brain after AbetaOs injection.	abetaos	195-202	NLR family, pyrin domain containing 3	Mus musculus	142-147
34490270-0	2021	alpha1-nAchR-Mediated Signaling Through Lipid Raft Is Required for Nicotine-Induced NLRP3 Inflammasome Activation and Nicotine-Accelerated Atherosclerosis.	Nicotine	67-75	NLR family, pyrin domain containing 3	Mus musculus	84-89
34490270-3	2021	Here, we aim to identify the essential role of lipid raft in mediating nicotine-triggered inflammatory and nicotine-accelerated atherosclerosis, and to figure out the specific receptor of nicotine-induced Nod-like receptor protein 3 (NLRP3) inflammasome activation in macrophage.	Nicotine	188-196	NLR family, pyrin domain containing 3	Mus musculus	205-232
34490270-3	2021	Here, we aim to identify the essential role of lipid raft in mediating nicotine-triggered inflammatory and nicotine-accelerated atherosclerosis, and to figure out the specific receptor of nicotine-induced Nod-like receptor protein 3 (NLRP3) inflammasome activation in macrophage.	Nicotine	188-196	NLR family, pyrin domain containing 3	Mus musculus	234-239
34490270-6	2021	We confirmed that nicotine triggered NLRP3 inflammasome activation and induced macrophage migration into atherosclerotic plaque, thus accelerated atherosclerosis in apoE-/- mice fed with a high-fat diet.	Nicotine	18-26	NLR family, pyrin domain containing 3	Mus musculus	37-42
34490270-7	2021	Mechanically, nicotine increased the expression of alpha1-nAChR and stimulated the accumulation of alpha1-nAChR in lipid raft, leading to NLRP3 inflammasome activation in macrophage.	Nicotine	14-22	NLR family, pyrin domain containing 3	Mus musculus	138-143
34490270-8	2021	Conversely, silencing of alpha1-nAChR in macrophage sufficiently blocked the pro-inflammasome activation effect of nicotine, indicating that alpha1-nAChR was the specific receptor for nicotine in triggering NLRP3 inflammasome in macrophage.	Nicotine	115-123	NLR family, pyrin domain containing 3	Mus musculus	207-212
34490270-8	2021	Conversely, silencing of alpha1-nAChR in macrophage sufficiently blocked the pro-inflammasome activation effect of nicotine, indicating that alpha1-nAChR was the specific receptor for nicotine in triggering NLRP3 inflammasome in macrophage.	Nicotine	184-192	NLR family, pyrin domain containing 3	Mus musculus	207-212
34490270-9	2021	Furthermore, both the destruction of lipid raft by methyl-beta-cyclodextrin and the interference of lipid raft clustering by silencing acid sphingomyelinase reversed nicotine-induced NLRP3 inflammasome activation by reducing the accumulation of alpha1-nAChR in lipid raft in macrophage, suggesting lipid raft-mediated accumulation of alpha1-nAChR was the key event in regulating the pro-inflammatory effects of nicotine in macrophage.	methyl-beta-cyclodextrin	51-75	NLR family, pyrin domain containing 3	Mus musculus	183-188
34490270-9	2021	Furthermore, both the destruction of lipid raft by methyl-beta-cyclodextrin and the interference of lipid raft clustering by silencing acid sphingomyelinase reversed nicotine-induced NLRP3 inflammasome activation by reducing the accumulation of alpha1-nAChR in lipid raft in macrophage, suggesting lipid raft-mediated accumulation of alpha1-nAChR was the key event in regulating the pro-inflammatory effects of nicotine in macrophage.	Nicotine	166-174	NLR family, pyrin domain containing 3	Mus musculus	183-188
34490270-9	2021	Furthermore, both the destruction of lipid raft by methyl-beta-cyclodextrin and the interference of lipid raft clustering by silencing acid sphingomyelinase reversed nicotine-induced NLRP3 inflammasome activation by reducing the accumulation of alpha1-nAChR in lipid raft in macrophage, suggesting lipid raft-mediated accumulation of alpha1-nAChR was the key event in regulating the pro-inflammatory effects of nicotine in macrophage.	Nicotine	411-419	NLR family, pyrin domain containing 3	Mus musculus	183-188
34490270-10	2021	Importantly, nicotine-induced NLRP3 inflammasome activation and macrophage migration into atherosclerotic plaque were reversed by methyl-beta-cyclodextrin, making a significant improvement for atherosclerosis in apoE-/- mice fed with a high-fat diet.	Nicotine	13-21	NLR family, pyrin domain containing 3	Mus musculus	30-35
34490270-10	2021	Importantly, nicotine-induced NLRP3 inflammasome activation and macrophage migration into atherosclerotic plaque were reversed by methyl-beta-cyclodextrin, making a significant improvement for atherosclerosis in apoE-/- mice fed with a high-fat diet.	methyl-beta-cyclodextrin	130-154	NLR family, pyrin domain containing 3	Mus musculus	30-35
34062252-0	2021	Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity.	Dronedarone	13-24	NLR family, pyrin domain containing 3	Mus musculus	46-51
34062252-2	2021	It is the first time that dronedarone, a multiply ion channel blocker, was identified as a NLRP3-inflammasome inhibitor with an IC50 value of 6.84 muM against IL-1beta release.	Dronedarone	26-37	NLR family, pyrin domain containing 3	Mus musculus	91-96
34062252-3	2021	A series of novel 5-amide benzofuran derivatives were designed and synthesized as NLRP3-inflammasome inhibitors.	5-amide benzofuran	18-36	NLR family, pyrin domain containing 3	Mus musculus	82-87
34062252-5	2021	Notably, treatment with 8c could significantly inhibit NLRP3-mediated IL-1beta release and ameliorate peritoneal inflammation in a mouse model of sepsis.	N-(4-bromophenyl) 3-(4-bromophenylaminosulfonyl)benzamide	24-26	NLR family, pyrin domain containing 3	Mus musculus	55-60
34513923-0	2021	The Specific NLRP3 Antagonist IFM-514 Decreases Fibrosis and Inflammation in Experimental Murine Non-Alcoholic Steatohepatitis.	ifm-514	30-37	NLR family, pyrin domain containing 3	Mus musculus	13-18
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	2-5	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	epigallocatechin gallate	29-33	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	epigallocatechin gallate	124-150	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	epigallocatechin gallate	152-156	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	glutamyl-gamma-boronate	166-174	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	231-234	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-6	2022	Benefiting from the inflammation-homing effect of the macrophage membrane, the nanosystem delivers payloads (diagnostic probe and therapeutic drugs) to inflammatory lesions more efficiently and releases a chromophore and two drugs upon being triggered by the overexpressed in-situ ROS, thus exhibiting better theranostic performance in the autoimmune hepatitis and hind paw edema mouse models, including more salient imaging signals and better therapeutic efficacy via inhibiting NF-kappaB pathway and suppressing NLRP3 inflammasome activation.	ros	281-284	NLR family, pyrin domain containing 3	Mus musculus	514-519
34232130-0	2021	The impact of thiamine deficiency and benfotiamine treatment on Nod-like receptor protein-3 inflammasome in microglia.	Thiamine	14-22	NLR family, pyrin domain containing 3	Mus musculus	64-91
34232130-4	2021	In this study, we found that NLRP3 inflammasomes were significantly activated in the microglia of thiamine deficiency mice model.	Thiamine	98-106	NLR family, pyrin domain containing 3	Mus musculus	29-34
34232130-0	2021	The impact of thiamine deficiency and benfotiamine treatment on Nod-like receptor protein-3 inflammasome in microglia.	benphothiamine	38-50	NLR family, pyrin domain containing 3	Mus musculus	64-91
34376811-2	2022	Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process.	Uric Acid	9-12	NLR family, pyrin domain containing 3	Mus musculus	31-36
34232130-5	2021	In contrast, benfotiamine dampened inflammation NLRP3 mediated in BV2 cells stimulated with LPS and ATP through reducing mitochondrial reactive oxygen species levels and mitigating autophagy flux defect.	benphothiamine	13-25	NLR family, pyrin domain containing 3	Mus musculus	48-53
34232130-5	2021	In contrast, benfotiamine dampened inflammation NLRP3 mediated in BV2 cells stimulated with LPS and ATP through reducing mitochondrial reactive oxygen species levels and mitigating autophagy flux defect.	Adenosine Triphosphate	100-103	NLR family, pyrin domain containing 3	Mus musculus	48-53
34232130-5	2021	In contrast, benfotiamine dampened inflammation NLRP3 mediated in BV2 cells stimulated with LPS and ATP through reducing mitochondrial reactive oxygen species levels and mitigating autophagy flux defect.	reactive	135-143	NLR family, pyrin domain containing 3	Mus musculus	48-53
34376811-2	2022	Although MSU crystal-triggered NLRP3 inflammasome activation and interleukin 1beta (IL-1beta) release are known to have key roles in gouty arthritis, recent studies revealed that MSU crystal-induced necrosis also plays a critical role in this process.	Uric Acid	179-182	NLR family, pyrin domain containing 3	Mus musculus	31-36
34232130-5	2021	In contrast, benfotiamine dampened inflammation NLRP3 mediated in BV2 cells stimulated with LPS and ATP through reducing mitochondrial reactive oxygen species levels and mitigating autophagy flux defect.	oxygen species	144-158	NLR family, pyrin domain containing 3	Mus musculus	48-53
34376811-4	2022	Here, we showed that MSU crystal-induced necrosis in murine macrophages was not dependent on NLRP3 inflammasome activation, as neither genetic deletion nor pharmacological blockade of the NLRP3 pathway inhibited the necrosis.	Uric Acid	21-24	NLR family, pyrin domain containing 3	Mus musculus	188-193
34232130-6	2021	These data identify an important role of thiamine metabolism in NLRP3 inflammasome activation, and correcting thiamine metabolism through benfotiamine provides a new therapeutic strategy for NLRP3 inflammasome related neurological, metabolic, and inflammatory diseases.	Thiamine	41-49	NLR family, pyrin domain containing 3	Mus musculus	64-69
34376811-7	2022	Baicalin, a previously identified inhibitor of NLRP3, inhibited MSU crystal-induced inflammasome activation and suppressed the necrosis in macrophages.	baicalin	0-8	NLR family, pyrin domain containing 3	Mus musculus	47-52
34232130-6	2021	These data identify an important role of thiamine metabolism in NLRP3 inflammasome activation, and correcting thiamine metabolism through benfotiamine provides a new therapeutic strategy for NLRP3 inflammasome related neurological, metabolic, and inflammatory diseases.	benphothiamine	138-150	NLR family, pyrin domain containing 3	Mus musculus	191-196
34376811-9	2022	Altogether, our data indicate that MSU crystals induce NLRP3-independent necrosis, which can be inhibited by combined inhibitors for multiple signaling pathways, highlighting a new avenue for the treatment of gouty arthritis.	Uric Acid	35-38	NLR family, pyrin domain containing 3	Mus musculus	55-60
34439517-7	2021	Fewer cardiac sarcopenic changes and highly remarkable protective effects of melatonin treatment detected in aged cardiomyocytes of NLRP3-/- mice compared with aged WT animals, confirming implication of the NLRP3 inflammasome in cardiac aging.	Melatonin	77-86	NLR family, pyrin domain containing 3	Mus musculus	132-137
34349235-9	2022	ISO activated the NLRP3 inflammasome in both cardiomyocytes and mouse hearts, but this effect was alleviated by glibenclamide pretreatment.	Isoproterenol	0-3	NLR family, pyrin domain containing 3	Mus musculus	18-23
34439517-7	2021	Fewer cardiac sarcopenic changes and highly remarkable protective effects of melatonin treatment detected in aged cardiomyocytes of NLRP3-/- mice compared with aged WT animals, confirming implication of the NLRP3 inflammasome in cardiac aging.	Melatonin	77-86	NLR family, pyrin domain containing 3	Mus musculus	207-212
34421582-10	2021	Finally, the expression of TLR4, MYD88, phospho-IkappaBalpha, phospho-NF-kappaB and the NLRP3 inflammasome was significantly upregulated in LPS-induced BV2 microglial cells, while agmatine suppressed the expression of these proteins.	Agmatine	180-188	NLR family, pyrin domain containing 3	Mus musculus	88-93
34421582-12	2021	The inhibitory effect of agmatine on pyroptosis was mediated by the suppression of the TLR4/MYD88/NF-kappaB/NLRP3 inflammasome pathway.	Agmatine	25-33	NLR family, pyrin domain containing 3	Mus musculus	108-113
34349235-13	2022	In conclusion, glibenclamide alleviates beta-AR overactivation-induced cardiac inflammation by inhibiting the NLRP3 inflammasome.	Glyburide	15-28	NLR family, pyrin domain containing 3	Mus musculus	110-115
34349235-9	2022	ISO activated the NLRP3 inflammasome in both cardiomyocytes and mouse hearts, but this effect was alleviated by glibenclamide pretreatment.	Glyburide	112-125	NLR family, pyrin domain containing 3	Mus musculus	18-23
34349235-10	2022	Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome.	Isoproterenol	32-35	NLR family, pyrin domain containing 3	Mus musculus	139-144
34349235-10	2022	Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome.	Potassium	60-69	NLR family, pyrin domain containing 3	Mus musculus	139-144
34349235-10	2022	Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome.	ros	92-95	NLR family, pyrin domain containing 3	Mus musculus	139-144
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Adenosine Triphosphate	150-153	NLR family, pyrin domain containing 3	Mus musculus	115-120
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Nigericin	155-164	NLR family, pyrin domain containing 3	Mus musculus	115-120
34345943-0	2021	NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis.	Dextran Sulfate	83-105	NLR family, pyrin domain containing 3	Mus musculus	0-5
34377468-7	2021	Oxidised forms of these lipoproteins reduced the secretion of mature IL-1beta also by inhibiting the activation of NLRP3 inflammasome induced by SAA, ATP, nigericin and monosodium urate crystals.	Uric Acid	169-185	NLR family, pyrin domain containing 3	Mus musculus	115-120
34229586-3	2021	The mice and cellular models for IVD degeneration were established by using puncture method and H2O2 exposure, respectively, and we evidenced that NLRP3-mediated cell pyroptosis, apoptosis and inflammatory responses occurred during IVD degeneration progression in vitro and in vivo.	Hydrogen Peroxide	96-100	NLR family, pyrin domain containing 3	Mus musculus	147-152
34341510-10	2022	Knockdown of TWIK2 significantly impaired the inhibitory effect of ML365 on ATP-induced NLRP3 inflammasome activation.	ML365	67-72	NLR family, pyrin domain containing 3	Mus musculus	88-93
34341510-10	2022	Knockdown of TWIK2 significantly impaired the inhibitory effect of ML365 on ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	76-79	NLR family, pyrin domain containing 3	Mus musculus	88-93
34413860-6	2021	Treatment with RRx-001, an NLRP3 inhibitor, significantly reduced inflammatory cell infiltration and mucus secretion in the airway.	RRx-001	15-22	NLR family, pyrin domain containing 3	Mus musculus	27-32
34341510-0	2022	ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome.	ML365	0-5	NLR family, pyrin domain containing 3	Mus musculus	50-55
34341510-0	2022	ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome.	Adenosine Triphosphate	38-41	NLR family, pyrin domain containing 3	Mus musculus	50-55
34341510-2	2022	TWIK2 potassium channel mediates potassium efflux that has been reported to be an essential upstream mechanism for ATP-induced NLRP3 inflammasome activation.	Potassium	33-42	NLR family, pyrin domain containing 3	Mus musculus	127-132
34341510-2	2022	TWIK2 potassium channel mediates potassium efflux that has been reported to be an essential upstream mechanism for ATP-induced NLRP3 inflammasome activation.	Adenosine Triphosphate	115-118	NLR family, pyrin domain containing 3	Mus musculus	127-132
34341510-9	2022	We showed that ML365 (1, 5 muM) concentration-dependently inhibited ATP-induced NLRP3 inflammasome activation in LPS-primed murine BMDMs, whereas it did not affect nigericin-induced NLRP3, or non-canonical, AIM2 and NLRC4 inflammasomes activation.	ML365	15-20	NLR family, pyrin domain containing 3	Mus musculus	80-85
34341510-9	2022	We showed that ML365 (1, 5 muM) concentration-dependently inhibited ATP-induced NLRP3 inflammasome activation in LPS-primed murine BMDMs, whereas it did not affect nigericin-induced NLRP3, or non-canonical, AIM2 and NLRC4 inflammasomes activation.	Adenosine Triphosphate	68-71	NLR family, pyrin domain containing 3	Mus musculus	80-85
34341353-7	2021	Notably, N-induced lung injury and cytokine production are blocked by MCC950 (a specific inhibitor of NLRP3) and Ac-YVAD-cmk (an inhibitor of caspase-1).	Nitrogen	9-10	NLR family, pyrin domain containing 3	Mus musculus	102-107
34090877-0	2021	Identification of tubocapsanolide A as a novel NLRP3 inhibitor for potential treatment of colitis.	tubocapsanolide A	18-35	NLR family, pyrin domain containing 3	Mus musculus	47-52
34090877-3	2021	Here, we first reported that Tubocapsanolide A (TA), a natural small molecule, as a novel inhibitor of NLRP3 inflammasome for the treatment of colitis.	tubocapsanolide A	29-46	NLR family, pyrin domain containing 3	Mus musculus	103-108
34090877-3	2021	Here, we first reported that Tubocapsanolide A (TA), a natural small molecule, as a novel inhibitor of NLRP3 inflammasome for the treatment of colitis.	tubocapsanolide A	48-50	NLR family, pyrin domain containing 3	Mus musculus	103-108
34090877-4	2021	TA inhibited the activation of NLRP3 inflammasome and suppressed the secretion of IL-1beta and IL-18 in macrophages.	tubocapsanolide A	0-2	NLR family, pyrin domain containing 3	Mus musculus	31-36
34090877-6	2021	The assembly of the NLRP3 inflammasome was also restrained by TA, while had little effects on potassium and chloride efflux.	tubocapsanolide A	62-64	NLR family, pyrin domain containing 3	Mus musculus	20-25
34090877-7	2021	Biolayer interferometry analysis showed that TA could directly bind to NLRP3.	tubocapsanolide A	45-47	NLR family, pyrin domain containing 3	Mus musculus	71-76
34090877-8	2021	Importantly, LC-MS/MS analysis further demonstrated that TA covalently bound to the cysteine 514 residue (Cys514) of NLRP3.	tubocapsanolide A	57-59	NLR family, pyrin domain containing 3	Mus musculus	117-122
34090877-8	2021	Importantly, LC-MS/MS analysis further demonstrated that TA covalently bound to the cysteine 514 residue (Cys514) of NLRP3.	Cysteine	84-92	NLR family, pyrin domain containing 3	Mus musculus	117-122
34090877-10	2021	However, the protection of TA against DSS-induced experimental colitis was abrogated in NLRP3-deficient (Nlrp3-/-) mice.	tubocapsanolide A	27-29	NLR family, pyrin domain containing 3	Mus musculus	88-93
34090877-10	2021	However, the protection of TA against DSS-induced experimental colitis was abrogated in NLRP3-deficient (Nlrp3-/-) mice.	tubocapsanolide A	27-29	NLR family, pyrin domain containing 3	Mus musculus	105-110
34090877-11	2021	Taken together, this study indicates TA as a novel inhibitor of NLRP3, which identifies Cys514 as a novel regulatory site of NLRP3 and suggests TA as a promising candidate compound for the treatment of colitis.	tubocapsanolide A	37-39	NLR family, pyrin domain containing 3	Mus musculus	64-69
34090877-11	2021	Taken together, this study indicates TA as a novel inhibitor of NLRP3, which identifies Cys514 as a novel regulatory site of NLRP3 and suggests TA as a promising candidate compound for the treatment of colitis.	tubocapsanolide A	37-39	NLR family, pyrin domain containing 3	Mus musculus	125-130
34102208-0	2021	N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1beta signaling pathway.	Acetylcysteine	0-16	NLR family, pyrin domain containing 3	Mus musculus	101-106
34102208-0	2021	N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1beta signaling pathway.	Streptozocin	53-56	NLR family, pyrin domain containing 3	Mus musculus	101-106
34144035-0	2021	Topical calcitriol application promotes diabetic corneal wound healing and reinnervation through inhibiting NLRP3 inflammasome activation.	Calcitriol	8-18	NLR family, pyrin domain containing 3	Mus musculus	108-113
34144035-7	2021	Moreover, calcitriol ameliorated neutrophil infiltration and promoted the M1-to-M2 macrophage transition, accompanied by suppressed overactivation of the NLRP3 inflammasome.	Calcitriol	10-20	NLR family, pyrin domain containing 3	Mus musculus	154-159
34102208-10	2021	Moreover, NAC markedly attenuated ROS accumulation and decreased NLRP3, IL-1beta and caspase-1 levels in diabetic cornea and conjunctiva.	Acetylcysteine	10-13	NLR family, pyrin domain containing 3	Mus musculus	65-70
34144035-10	2021	In conclusion, topical calcitriol application promotes corneal wound healing and reinnervation during diabetes, which may be related to the suppression of the overactivation of NLRP3 inflammasome.	Calcitriol	23-33	NLR family, pyrin domain containing 3	Mus musculus	177-182
34102208-11	2021	These results suggest that NAC improves ocular surface damage in STZ-induced diabetic mice, which may be related to the inhibition of the ROS/NLRP3/Caspase-1/IL-1beta signaling pathway.	Acetylcysteine	27-30	NLR family, pyrin domain containing 3	Mus musculus	142-147
34178130-12	2021	Additionally, the protein expression levels of intercellular adhesion molecule 1, NLRP3, apoptosis-associated speck-like protein containing a CARD and cleaved caspase-1 were downregulated following emodin treatment.	Emodin	198-204	NLR family, pyrin domain containing 3	Mus musculus	82-87
34178130-14	2021	The present study demonstrated that emodin may offer protection against ALI induced by SAP via inhibiting and suppressing NLRP3 inflammasome-mediated neutrophil recruitment and may be a novel therapeutic strategy for the clinical treatment of ALI.	Emodin	36-42	NLR family, pyrin domain containing 3	Mus musculus	122-127
34178130-14	2021	The present study demonstrated that emodin may offer protection against ALI induced by SAP via inhibiting and suppressing NLRP3 inflammasome-mediated neutrophil recruitment and may be a novel therapeutic strategy for the clinical treatment of ALI.	BENSULIDE	87-90	NLR family, pyrin domain containing 3	Mus musculus	122-127
34102208-11	2021	These results suggest that NAC improves ocular surface damage in STZ-induced diabetic mice, which may be related to the inhibition of the ROS/NLRP3/Caspase-1/IL-1beta signaling pathway.	Streptozocin	65-68	NLR family, pyrin domain containing 3	Mus musculus	142-147
34102208-11	2021	These results suggest that NAC improves ocular surface damage in STZ-induced diabetic mice, which may be related to the inhibition of the ROS/NLRP3/Caspase-1/IL-1beta signaling pathway.	Reactive Oxygen Species	138-141	NLR family, pyrin domain containing 3	Mus musculus	142-147
34180140-0	2021	HDAC6 inhibitor ACY1215 inhibits the activation of NLRP3 inflammasome in acute liver failure by regulating the ATM/F-actin signalling pathway.	ricolinostat	16-23	NLR family, pyrin domain containing 3	Mus musculus	51-56
34314075-0	2021	Cf-02, a novel benzamide-linked small molecule, blunts NF-kappaB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice.	cf-02	0-5	NLR family, pyrin domain containing 3	Mus musculus	80-85
34314075-0	2021	Cf-02, a novel benzamide-linked small molecule, blunts NF-kappaB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and severe lupus nephritis in mice.	benzamide	15-24	NLR family, pyrin domain containing 3	Mus musculus	80-85
34314075-1	2021	In the present study, acute onset of severe lupus nephritis was successfully treated in mice using a new, benzamide-linked, small molecule that targets immune modulation and the NLRP3 inflammasome.	benzamide	106-115	NLR family, pyrin domain containing 3	Mus musculus	178-183
34180140-10	2021	These results indicated that ACY1215 exhibited hepatoprotective properties, which was associated with the inhibition of NLRP3 inflammasome, and this effect of ACY1215 was connected with upregulation of the ATM/F-actin mediated signalling pathways.	ricolinostat	29-36	NLR family, pyrin domain containing 3	Mus musculus	120-125
34278447-0	2021	Astragaloside IV ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome-mediated inflammation.	astragaloside	0-13	NLR family, pyrin domain containing 3	Mus musculus	78-83
34180140-5	2021	Moreover, ACY1215 inhibited the level of NLRP3, ASC, caspase-1, IL-1beta and IL-18 in ALF.	ricolinostat	10-17	NLR family, pyrin domain containing 3	Mus musculus	41-46
34180143-0	2021	Kakonein restores diabetes-induced endothelial junction dysfunction via promoting autophagy-mediated NLRP3 inflammasome degradation.	puerarin	0-8	NLR family, pyrin domain containing 3	Mus musculus	101-106
34180140-9	2021	Cytochalasin B could dramatically increase the level of NLRP3, ASC, caspase-1, IL-1beta and IL-18 in ALF with ACY1215 pretreatment.	ricolinostat	110-117	NLR family, pyrin domain containing 3	Mus musculus	56-61
34180143-5	2021	The protective effect of kakonein on cardiovascular endothelial junctions and NLRP3 inflammasome activation was verified through immunofluorescence and ELISA assay.	puerarin	25-33	NLR family, pyrin domain containing 3	Mus musculus	78-83
34109437-12	2021	The effect of RSV may be achieved by inhibiting the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88/nuclear factor-kappaB signaling pathway.	Resveratrol	14-17	NLR family, pyrin domain containing 3	Mus musculus	52-103
34180143-7	2021	Results showed that kakonein restored the function of endothelial junctions and inhibited the assembly and activation of the NLRP3 inflammasome.	puerarin	20-28	NLR family, pyrin domain containing 3	Mus musculus	125-130
34180143-10	2021	In addition, kakonein inhibited both hyperglycaemia-induced cardiovascular endothelial junction dysfunction and NLRP3 inflammasome activation, similar to autophagy agonist.	puerarin	13-21	NLR family, pyrin domain containing 3	Mus musculus	112-117
34180143-11	2021	Our findings indicated that kakonein exerts a protective effect on hyperglycaemia-induced chronic vascular disease by regulating the NLRP3 inflammasome through autophagy.	puerarin	28-36	NLR family, pyrin domain containing 3	Mus musculus	133-138
34109437-12	2021	The effect of RSV may be achieved by inhibiting the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88/nuclear factor-kappaB signaling pathway.	Resveratrol	14-17	NLR family, pyrin domain containing 3	Mus musculus	105-110
34109437-13	2021	In conclusion, RSV may improve kidney inflammation through TLR4 and NLRP3 signaling pathways, and reduce the expression of UA transporter proteins in the kidney of insulin-resistant mice, thereby reducing blood UA levels.	Resveratrol	15-18	NLR family, pyrin domain containing 3	Mus musculus	68-73
34217831-0	2021	Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis.	cucurbitacin B	0-14	NLR family, pyrin domain containing 3	Mus musculus	91-96
34082381-0	2021	Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	93-98
34393799-0	2021	Isoforskolin Alleviates AECOPD by Improving Pulmonary Function and Attenuating Inflammation Which Involves Downregulation of Th17/IL-17A and NF-kappaB/NLRP3.	Isoforskolin	0-12	NLR family, pyrin domain containing 3	Mus musculus	151-156
34393799-13	2021	Furthermore, ISOF significantly inhibited the activation of NF-kappaB signaling and NLRP3 inflammasome in the lung tissues of model mice.	Isof	13-17	NLR family, pyrin domain containing 3	Mus musculus	84-89
34319504-0	2021	Effect of Curcumol on NOD-Like Receptor Thermoprotein Domain 3 Inflammasomes in Liver Fibrosis of Mice.	curcumol	10-18	NLR family, pyrin domain containing 3	Mus musculus	22-62
34440688-0	2021	Lower Temperatures Exacerbate NLRP3 Inflammasome Activation by Promoting Monosodium Urate Crystallization, Causing Gout.	Uric Acid	73-89	NLR family, pyrin domain containing 3	Mus musculus	30-35
34440688-2	2021	Macrophages intake MSU crystals, the trigger for NLRP3 inflammasome activation, which leads to the release of interleukin (IL)-1beta and results in the flaring of gout.	Uric Acid	19-22	NLR family, pyrin domain containing 3	Mus musculus	49-54
34440688-8	2021	MSU crystals at lower temperatures enhanced IL-1beta secretion via the NLRP3 inflammasome pathway.	Uric Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	71-76
34125142-0	2021	Histidine ameliorates elastase- and lipopolysaccharide-induced lung inflammation by inhibiting the activation of the NLRP3 inflammasome.	Histidine	0-9	NLR family, pyrin domain containing 3	Mus musculus	117-122
34125142-7	2021	In addition, histidine treatment ameliorated lung inflammation by inhibiting the nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 inflammasome activation both in vivo and in vitro.	Histidine	13-22	NLR family, pyrin domain containing 3	Mus musculus	81-175
34368345-13	2021	Lu exhibited therapeutical effects on D-GaI/LPS induced liver injury in mice which might be related to the regulation of the NLRP3/NF-kappaB pathway.	Luteolin	0-2	NLR family, pyrin domain containing 3	Mus musculus	125-130
34368345-13	2021	Lu exhibited therapeutical effects on D-GaI/LPS induced liver injury in mice which might be related to the regulation of the NLRP3/NF-kappaB pathway.	d-gai	38-43	NLR family, pyrin domain containing 3	Mus musculus	125-130
34319504-1	2021	OBJECTIVE: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.	curcumol	40-48	NLR family, pyrin domain containing 3	Mus musculus	52-92
34319504-1	2021	OBJECTIVE: To investigate the effect of curcumol on NOD-like receptor thermoprotein domain 3 (NLRP3) inflammasomes, and analyze the mechanism underlying curcumol against liver fibrosis.	curcumol	40-48	NLR family, pyrin domain containing 3	Mus musculus	94-99
34319504-11	2021	CONCLUSION: A potential anti-liver fibrosis mechanism of curcumol may be associated with the inhibition of NLRP3 inflammasomes and decreasing the downstream inflammatory response.	curcumol	57-65	NLR family, pyrin domain containing 3	Mus musculus	107-112
34315884-0	2021	Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.	Chlorides	0-8	NLR family, pyrin domain containing 3	Mus musculus	35-40
34395445-6	2021	The GsdmD-/- macrophages were more resistant to Nlrp3 inflammasome mediated reduction in cholesterol efflux, showing ~26% decrease vs. ~60% reduction in WT macrophages.	Cholesterol	89-100	NLR family, pyrin domain containing 3	Mus musculus	48-53
34349501-16	2021	Conclusion: BBR exerts anti-HUA and nephroprotective effects via inhibiting activation of NLRP3 inflammasome and correcting the aberrant expression of URAT1 in kidney.	Berberine	12-15	NLR family, pyrin domain containing 3	Mus musculus	90-95
34301253-3	2021	We aimed to evaluate the effects of EMPA on myocardial strain of non-diabetic mice treated with doxorubicin (DOXO) through the analysis of NLRP3 inflammasome and MyD88-related pathways resulting in anti-apoptotic and anti-fibrotic effects.	empagliflozin	36-40	NLR family, pyrin domain containing 3	Mus musculus	139-144
34335040-15	2021	Conclusion: NLRP3 inflammasome activation in concert with increased release of exosomes containing IL-1beta or other inflammasome products contributes to the development of lung inflammation and injury during PPE-induced emphysema and that EA of lung-specific acupoints attenuates inflammasome activation and exosome release, thereby reducing inflammatory response in the lung of mice with emphysema.	ppe	209-212	NLR family, pyrin domain containing 3	Mus musculus	12-17
34301253-3	2021	We aimed to evaluate the effects of EMPA on myocardial strain of non-diabetic mice treated with doxorubicin (DOXO) through the analysis of NLRP3 inflammasome and MyD88-related pathways resulting in anti-apoptotic and anti-fibrotic effects.	Doxorubicin	96-107	NLR family, pyrin domain containing 3	Mus musculus	139-144
34301253-3	2021	We aimed to evaluate the effects of EMPA on myocardial strain of non-diabetic mice treated with doxorubicin (DOXO) through the analysis of NLRP3 inflammasome and MyD88-related pathways resulting in anti-apoptotic and anti-fibrotic effects.	Doxorubicin	109-113	NLR family, pyrin domain containing 3	Mus musculus	139-144
34301253-16	2021	A reduced expression of pro-inflammatory cytokines, NLRP3, MyD88 and NF-kB in heart, liver and kidneys was also seen in DOXO-EMPA group compared to DOXO (p < 0.001).	doxo-empa	120-129	NLR family, pyrin domain containing 3	Mus musculus	52-57
34301253-16	2021	A reduced expression of pro-inflammatory cytokines, NLRP3, MyD88 and NF-kB in heart, liver and kidneys was also seen in DOXO-EMPA group compared to DOXO (p < 0.001).	Doxorubicin	148-152	NLR family, pyrin domain containing 3	Mus musculus	52-57
34301253-17	2021	CONCLUSION: EMPA reduced ferroptosis, fibrosis, apoptosis and inflammation in doxorubicin-treated mice through the involvement of NLRP3 and MyD88-related pathways, resulting in significant improvements in cardiac functions.	empagliflozin	12-16	NLR family, pyrin domain containing 3	Mus musculus	130-135
34301253-17	2021	CONCLUSION: EMPA reduced ferroptosis, fibrosis, apoptosis and inflammation in doxorubicin-treated mice through the involvement of NLRP3 and MyD88-related pathways, resulting in significant improvements in cardiac functions.	Doxorubicin	78-89	NLR family, pyrin domain containing 3	Mus musculus	130-135
34308845-0	2021	(Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells).	mangion-purified polysaccharide (Candida albicans)	50-54	NLR family, pyrin domain containing 3	Mus musculus	68-73
34367186-17	2021	Rux application suppressed lipopolysaccharide (LPS)-induced NLRP3 inflammasome secretion and JAK2/STAT3 pathway activation in the OGD/R model in vitro.	ruxolitinib	0-3	NLR family, pyrin domain containing 3	Mus musculus	60-65
34294138-6	2021	Human myeloid leukemia mononuclear (THP-1) cells and mouse peritoneal macrophages (MPMs) were stimulated with lipopolysaccharides (LPS) and Nigericin to activate NLRP3 inflammasomes, which simulated an inflammation environment in vitro.	Nigericin	140-149	NLR family, pyrin domain containing 3	Mus musculus	162-167
34284768-10	2021	In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA.	Uric Acid	67-70	NLR family, pyrin domain containing 3	Mus musculus	13-18
34284768-10	2021	In addition, NLRP3, Caspase-1 and IL-1beta, which are activated by MSU were also suppressed by SHA.	salicylhydroxamic acid	95-98	NLR family, pyrin domain containing 3	Mus musculus	13-18
34308845-0	2021	(Macrophage migration inhibitory factor meditates MPP+/MPTP-induced NLRP3 inflammasome activation in microglia cells).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	55-59	NLR family, pyrin domain containing 3	Mus musculus	68-73
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	MPP+ iodide	132-166	NLR family, pyrin domain containing 3	Mus musculus	252-279
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	MPP+ iodide	132-166	NLR family, pyrin domain containing 3	Mus musculus	281-286
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	-methyl-	176-184	NLR family, pyrin domain containing 3	Mus musculus	252-279
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	-methyl-	176-184	NLR family, pyrin domain containing 3	Mus musculus	281-286
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	-phenyl-1, 2, 3, 6-tetrahydropyridine	185-222	NLR family, pyrin domain containing 3	Mus musculus	252-279
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	-phenyl-1, 2, 3, 6-tetrahydropyridine	185-222	NLR family, pyrin domain containing 3	Mus musculus	281-286
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	224-228	NLR family, pyrin domain containing 3	Mus musculus	252-279
34308845-1	2021	OBJECTIVE: To explore the mechanisms of macrophage migration inhibitory factor (MIF)/nucleus factor-kappaB (NF-kappaB) in mediating 1-methyl-4-phenylpyridinium iodide (MPP +)/1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced activation of Nod-like receptor protein 3 (NLRP3) inflammasome in microglials and the its effects on neurons.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	224-228	NLR family, pyrin domain containing 3	Mus musculus	281-286
34349759-9	2021	Poly(I:C)-MTV injury was sensitive to caspase-11 deletion with no further contribution of caspase-1 except for maturation and release of IL-18 (that itself was sensitive to deletion of NLRP3).	Poly I-C	0-9	NLR family, pyrin domain containing 3	Mus musculus	185-190
34308845-7	2021	RESULTS: MPP+ significantly increased NLRP3 and MIF expressions in Bv-2 cells (P < 0.05).	mangion-purified polysaccharide (Candida albicans)	9-13	NLR family, pyrin domain containing 3	Mus musculus	38-43
34308845-11	2021	Compared with those in MPTP group, the mice receiving injections of AAV-MIF-shRNA had higher scores in pole test and open field test with lower scores in traction test, and showed increased TH-positive neurons, decreased Iba-1 microglia cell activation, reduced expressions of MIF and NLRP3, and increased expression of TH in he substantia nigra (all P < 0.05).	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	23-27	NLR family, pyrin domain containing 3	Mus musculus	285-290
34308845-12	2021	CONCLUSION: Inhibition of MIF can reduce the expression of NLRP3 inflammasomes and inflammatory factor caused by MPP+ in microglia cells to relieve the damage of dopaminergic neurons and alleviate microglia cell activation, thus offering protection against neuroinflammation in Parkinson"s disease.	mangion-purified polysaccharide (Candida albicans)	113-117	NLR family, pyrin domain containing 3	Mus musculus	59-64
34335562-8	2021	Additionally, analysis of nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) and NLR with CARD domain-containing 4 (NLRC4) in J774A.1 cells indicated that spvC decreased the protein levels of NLRP3 and NLRC4, which were significantly changed by autophagy inhibitor Bafilomycin A1.	bafilomycin A1	315-329	NLR family, pyrin domain containing 3	Mus musculus	120-125
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	Uric Acid	44-47	NLR family, pyrin domain containing 3	Mus musculus	336-341
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	Uric Acid	109-112	NLR family, pyrin domain containing 3	Mus musculus	336-341
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	Colchicine	117-127	NLR family, pyrin domain containing 3	Mus musculus	336-341
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	noni fruit juice	133-149	NLR family, pyrin domain containing 3	Mus musculus	336-341
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	Uric Acid	170-173	NLR family, pyrin domain containing 3	Mus musculus	336-341
34359507-3	2021	Compared with the model group (treated with MSU), mice in both the positive control group (treated with both MSU and colchicine) and noni fruit juice group (treated with MSU and noni fruit juice) showed a significantly decreased degree of paw swelling in 5 days, as well as the contents of two types of proinflammatory cytokines (i.e., NALP3 and TNF-alpha).	noni fruit juice	178-194	NLR family, pyrin domain containing 3	Mus musculus	336-341
34335245-0	2021	Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling.	Flavones	6-14	NLR family, pyrin domain containing 3	Mus musculus	164-169
34335245-11	2021	TFA and 740Y-P inhibited activation of the NLRP3 inflammasome via the PI3K/Akt pathway by inhibiting the protein levels of NIMA-related kinase7, NLRP3, ASC, and caspase-1, and by increasing the protein expression levels of p-PI3K and p-Akt.	Trifluoroacetic Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	43-48
34335245-11	2021	TFA and 740Y-P inhibited activation of the NLRP3 inflammasome via the PI3K/Akt pathway by inhibiting the protein levels of NIMA-related kinase7, NLRP3, ASC, and caspase-1, and by increasing the protein expression levels of p-PI3K and p-Akt.	Trifluoroacetic Acid	0-3	NLR family, pyrin domain containing 3	Mus musculus	145-150
34335245-11	2021	TFA and 740Y-P inhibited activation of the NLRP3 inflammasome via the PI3K/Akt pathway by inhibiting the protein levels of NIMA-related kinase7, NLRP3, ASC, and caspase-1, and by increasing the protein expression levels of p-PI3K and p-Akt.	740y-p	8-14	NLR family, pyrin domain containing 3	Mus musculus	43-48
34335245-11	2021	TFA and 740Y-P inhibited activation of the NLRP3 inflammasome via the PI3K/Akt pathway by inhibiting the protein levels of NIMA-related kinase7, NLRP3, ASC, and caspase-1, and by increasing the protein expression levels of p-PI3K and p-Akt.	740y-p	8-14	NLR family, pyrin domain containing 3	Mus musculus	145-150
34335245-13	2021	Conclusion: Collectively, our data indicated that TFA could ameliorate pyroptosis and injury in podocytes under HG conditions by adjusting METTL3-dependent m6A modification and regulating NLRP3-inflammasome activation and PTEN/PI3K/Akt signaling.	Trifluoroacetic Acid	50-53	NLR family, pyrin domain containing 3	Mus musculus	188-193
34335248-7	2021	The reduction of NLRP3 inflammasome activation and excessive fission of mitochondria mediated by Drp1 were associated with the administration of atractylenolide I. Upregulation of Drp1 reversed the inhibitory effect of atractylenolide I on the activation of NLRP3 inflammasomes.	(+)-Atractylenolide	145-160	NLR family, pyrin domain containing 3	Mus musculus	17-22
34335248-7	2021	The reduction of NLRP3 inflammasome activation and excessive fission of mitochondria mediated by Drp1 were associated with the administration of atractylenolide I. Upregulation of Drp1 reversed the inhibitory effect of atractylenolide I on the activation of NLRP3 inflammasomes.	(+)-Atractylenolide	145-160	NLR family, pyrin domain containing 3	Mus musculus	258-263
34335248-7	2021	The reduction of NLRP3 inflammasome activation and excessive fission of mitochondria mediated by Drp1 were associated with the administration of atractylenolide I. Upregulation of Drp1 reversed the inhibitory effect of atractylenolide I on the activation of NLRP3 inflammasomes.	atractylenolide I	219-236	NLR family, pyrin domain containing 3	Mus musculus	17-22
34335248-7	2021	The reduction of NLRP3 inflammasome activation and excessive fission of mitochondria mediated by Drp1 were associated with the administration of atractylenolide I. Upregulation of Drp1 reversed the inhibitory effect of atractylenolide I on the activation of NLRP3 inflammasomes.	atractylenolide I	219-236	NLR family, pyrin domain containing 3	Mus musculus	258-263
34335248-9	2021	Atractylenolide I inhibited NLRP3 and caspase-1 expression in mice BMDMs, with no influence in the Drp1-overexpressed BMDMs.	(+)-Atractylenolide	0-15	NLR family, pyrin domain containing 3	Mus musculus	28-33
34335248-10	2021	These results demonstrated that atractylenolide I inhibits NLRP3 inflammasome activation in colitis-associated colorectal cancer via suppressing Drp1-mediated mitochondrial fission.	atractylenolide I	32-49	NLR family, pyrin domain containing 3	Mus musculus	59-64
34335562-8	2021	Additionally, analysis of nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) and NLR with CARD domain-containing 4 (NLRC4) in J774A.1 cells indicated that spvC decreased the protein levels of NLRP3 and NLRC4, which were significantly changed by autophagy inhibitor Bafilomycin A1.	bafilomycin A1	315-329	NLR family, pyrin domain containing 3	Mus musculus	242-247
34322027-0	2021	C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome.	C646	0-4	NLR family, pyrin domain containing 3	Mus musculus	61-66
34327209-0	2021	NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice.	1,2-bis(isothiazol-5-yl)disulfane	0-6	NLR family, pyrin domain containing 3	Mus musculus	80-85
34327209-19	2021	Conclusions: NU9056 might effectively alleviate LPS-induced cognitive impairment and emotional disorder in experimental mice by inhibiting the NLRP3 inflammasome.	1,2-bis(isothiazol-5-yl)disulfane	13-19	NLR family, pyrin domain containing 3	Mus musculus	143-148
34322027-4	2021	Here, we identified that C646, an inhibitor of histone acetyltransferase p300, exerts anti-inflammatory effects in DSS-induced colitis mice by targeting the NLRP3 inflammasome.	C646	25-29	NLR family, pyrin domain containing 3	Mus musculus	157-162
34322027-5	2021	Mechanistically, C646 not only inhibits NF-kappaB activation, leading to the decreased expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and NLRP3, but also suppresses the NLRP3 inflammasome assembly by disrupting the interaction between NLRP3 and ASC.	C646	17-21	NLR family, pyrin domain containing 3	Mus musculus	164-169
34322027-5	2021	Mechanistically, C646 not only inhibits NF-kappaB activation, leading to the decreased expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and NLRP3, but also suppresses the NLRP3 inflammasome assembly by disrupting the interaction between NLRP3 and ASC.	C646	17-21	NLR family, pyrin domain containing 3	Mus musculus	195-200
34322027-5	2021	Mechanistically, C646 not only inhibits NF-kappaB activation, leading to the decreased expression of pro-inflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) and NLRP3, but also suppresses the NLRP3 inflammasome assembly by disrupting the interaction between NLRP3 and ASC.	C646	17-21	NLR family, pyrin domain containing 3	Mus musculus	261-266
34285539-0	2021	Grape Seed Proanthocyanidin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway.	grape seed proanthocyanidin extract	0-35	NLR family, pyrin domain containing 3	Mus musculus	113-118
34322027-7	2021	Thus, our results demonstrate the ability of C646 to suppress the NLRP3 inflammasome activity and its potential application in the treatment of inflammatory bowel disease.	C646	45-49	NLR family, pyrin domain containing 3	Mus musculus	66-71
34285539-2	2021	Grape seed proanthocyanidin extract (GSPE) alleviates senescence-related degenerative disorders; however, the potential effects of GSPE intake on RPE cellular senescence through regulating NAMPT/SIRT1/NLRP3 pathway remain unclear.	gspe	37-41	NLR family, pyrin domain containing 3	Mus musculus	201-206
34234439-8	2021	The in vitro results demonstrated that milrinone could inhibit the secretion of interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha via regulation of NLRP3 inflammasomes and TLR4/MyD88/NF-kappaB signalling pathway.	Milrinone	39-48	NLR family, pyrin domain containing 3	Mus musculus	166-171
34285539-2	2021	Grape seed proanthocyanidin extract (GSPE) alleviates senescence-related degenerative disorders; however, the potential effects of GSPE intake on RPE cellular senescence through regulating NAMPT/SIRT1/NLRP3 pathway remain unclear.	gspe	131-135	NLR family, pyrin domain containing 3	Mus musculus	201-206
34285539-13	2021	Conclusion: This study indicated that GSPE alleviated RPE cellular senescence through NAMPT/SIRT1/NLRP3 pathway.	gspe	38-42	NLR family, pyrin domain containing 3	Mus musculus	98-103
34285539-14	2021	This study highlighted the potential effects of GSPE on degenerative retinopathy through the crosstalk of NAD+ metabolism, SIRT1 function and NLRP3 activation.	gspe	48-52	NLR family, pyrin domain containing 3	Mus musculus	142-147
34267535-0	2021	Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson"s Disease.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	58-63
34267535-11	2021	Additionally, melatonin reduced MPTP-induced microglial activation and suppressed NLRP3 inflammasome activity, and also inhibited IL-1beta secretion.	Melatonin	14-23	NLR family, pyrin domain containing 3	Mus musculus	82-87
34267535-12	2021	Moreover, in MPP+-primed BV2 cells, melatonin markedly restored the downregulation of SIRT1 and attenuated the activation of the NLRP3 inflammasome.	Melatonin	36-45	NLR family, pyrin domain containing 3	Mus musculus	129-134
34267535-14	2021	Conclusion: In conclusion, our data demonstrated that melatonin attenuates neuroinflammation by negatively regulating NLRP3 inflammasome activation via a SIRT1-dependent pathway in MPTP-induced PD models.	Melatonin	54-63	NLR family, pyrin domain containing 3	Mus musculus	118-123
34356130-6	2021	Furthermore, we found that high glucose promoted the interaction of TREM2 with NLRP3.	Glucose	32-39	NLR family, pyrin domain containing 3	Mus musculus	79-84
34356130-8	2021	Moreover, TREM2 KO reduced high glucose-induced NLRP3 inflammasome activation, and TREM2 OE augmented high glucose-induced NLRP3 inflammasome activation, indicating that high glucose enhances the expression of TREM2, which activates the NLRP3 inflammasome.	Glucose	32-39	NLR family, pyrin domain containing 3	Mus musculus	48-53
34356130-8	2021	Moreover, TREM2 KO reduced high glucose-induced NLRP3 inflammasome activation, and TREM2 OE augmented high glucose-induced NLRP3 inflammasome activation, indicating that high glucose enhances the expression of TREM2, which activates the NLRP3 inflammasome.	Glucose	107-114	NLR family, pyrin domain containing 3	Mus musculus	123-128
34356130-8	2021	Moreover, TREM2 KO reduced high glucose-induced NLRP3 inflammasome activation, and TREM2 OE augmented high glucose-induced NLRP3 inflammasome activation, indicating that high glucose enhances the expression of TREM2, which activates the NLRP3 inflammasome.	Glucose	107-114	NLR family, pyrin domain containing 3	Mus musculus	237-242
34356130-8	2021	Moreover, TREM2 KO reduced high glucose-induced NLRP3 inflammasome activation, and TREM2 OE augmented high glucose-induced NLRP3 inflammasome activation, indicating that high glucose enhances the expression of TREM2, which activates the NLRP3 inflammasome.	Glucose	175-182	NLR family, pyrin domain containing 3	Mus musculus	237-242
34229722-12	2021	Conversely, NLRP3 depletion protected against cognitive dysfunction, neuroinflammation, and neurological damage induced by DSS.	dss	123-126	NLR family, pyrin domain containing 3	Mus musculus	12-17
34217890-7	2022	The levels of the ATP-gated P2X7-Ca2+/K+ channel and ER-IP3R-Ca2+ channel, and of the mitochondrial anti-viral protein (MAVS), mediating NLRP3 inflammasome assembly and activation, were highly increased in DSS-treated mice, but not when VBIT-12 treated.	Dextran Sulfate	206-209	NLR family, pyrin domain containing 3	Mus musculus	137-142
34353086-1	2021	BACKGROUND: Safflower extract (SE) improves depression in mice by inhibiting the TLR4-NLRP3 inflammatory signaling pathway.	Selenium	31-33	NLR family, pyrin domain containing 3	Mus musculus	86-91
34353086-11	2021	The decrease of NLRP3 and caspase-1 were obviously reversed after administration of SE (10 or 30 mg/kg) or FLU (10 mg/kg).	Selenium	84-86	NLR family, pyrin domain containing 3	Mus musculus	16-21
34353086-11	2021	The decrease of NLRP3 and caspase-1 were obviously reversed after administration of SE (10 or 30 mg/kg) or FLU (10 mg/kg).	Fluoxetine	107-110	NLR family, pyrin domain containing 3	Mus musculus	16-21
34232433-1	2021	PURPOSE: Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK).	Ticagrelor	9-19	NLR family, pyrin domain containing 3	Mus musculus	73-92
34232433-1	2021	PURPOSE: Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK).	Ticagrelor	9-19	NLR family, pyrin domain containing 3	Mus musculus	94-99
34232433-1	2021	PURPOSE: Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK).	dapagliflozin	24-37	NLR family, pyrin domain containing 3	Mus musculus	73-92
34232433-1	2021	PURPOSE: Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK).	dapagliflozin	24-37	NLR family, pyrin domain containing 3	Mus musculus	94-99
34232433-4	2021	We assessed whether dapagliflozin and ticagrelor have additive effects on the activation of the NLRP3-inflammasome and the progression of diabetic nephropathy in mice with type-2 diabetes.	Ticagrelor	38-48	NLR family, pyrin domain containing 3	Mus musculus	96-101
34276337-7	2021	Additionally, attenuation of mitochondrial reactive oxygen species (mitoROS) via mito-apocynin and amelioration of ERS via the eIF2alpha inhibitor salubrinal (SAL) reduced the induction of the ERS/TXNIP/NLRP3 signaling axis, suggesting that mitochondrial dysfunction and ERS may act in concert to promote the alphaSynagg-induced microglial activation response.	salubrinal	147-157	NLR family, pyrin domain containing 3	Mus musculus	203-208
34276337-7	2021	Additionally, attenuation of mitochondrial reactive oxygen species (mitoROS) via mito-apocynin and amelioration of ERS via the eIF2alpha inhibitor salubrinal (SAL) reduced the induction of the ERS/TXNIP/NLRP3 signaling axis, suggesting that mitochondrial dysfunction and ERS may act in concert to promote the alphaSynagg-induced microglial activation response.	salubrinal	159-162	NLR family, pyrin domain containing 3	Mus musculus	203-208
34276337-8	2021	Likewise, knockdown of TXNIP by siRNA attenuated the alphaSynagg-induced NLRP3 inflammasome activation response.	alphasynagg	53-64	NLR family, pyrin domain containing 3	Mus musculus	73-78
34076707-3	2021	This study aims to investigate the effects of FSTL1 in ovalbumin (OVA)-induced mice and macrophages on nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3)/interleukin-1beta (IL-1beta) signaling pathway.	Leucine	133-140	NLR family, pyrin domain containing 3	Mus musculus	164-169
34395544-0	2021	SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation.	Aldosterone	17-28	NLR family, pyrin domain containing 3	Mus musculus	98-103
34257682-18	2021	The protein expression of NLRP3, ASC, Cle-caspase-1, IL-1beta, TXNIP, Cle-caspase-3, and Bax was downregulated in the LHF and perindopril treatment group, and Bcl-2 expression was upregulated.	Perindopril	126-137	NLR family, pyrin domain containing 3	Mus musculus	26-31
34395544-2	2021	Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.	Aldosterone	156-167	NLR family, pyrin domain containing 3	Mus musculus	54-90
34395544-2	2021	Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.	Aldosterone	156-167	NLR family, pyrin domain containing 3	Mus musculus	92-97
34234503-10	2021	Treatment with the H2S donor NaHS delayed LPS-induced preterm birth in mice and inhibited NLRP3 inflammasome activation.	Deuterium	19-22	NLR family, pyrin domain containing 3	Mus musculus	90-95
34234503-10	2021	Treatment with the H2S donor NaHS delayed LPS-induced preterm birth in mice and inhibited NLRP3 inflammasome activation.	sodium bisulfide	29-33	NLR family, pyrin domain containing 3	Mus musculus	90-95
34172438-5	2021	Furthermore, mitigation of intra-articular inflammation by targeting the NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3) inflammasome protects articular cartilage from damage in a murine model of knee septic arthritis.	Leucine	124-131	NLR family, pyrin domain containing 3	Mus musculus	73-78
34248643-0	2021	IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy.	iiim-941	0-8	NLR family, pyrin domain containing 3	Mus musculus	41-46
34248643-0	2021	IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy.	Stilbenes	12-20	NLR family, pyrin domain containing 3	Mus musculus	41-46
34248643-3	2021	In this study, we attempted to target NLRP3 inflammasome activity by a synthetic compound IIIM-941.	iiim-941	90-98	NLR family, pyrin domain containing 3	Mus musculus	38-43
34248643-4	2021	We found that IIIM-941 inhibits ATP induced NLRP3 inflammasome by induction of autophagy through AMPK pathway in bone marrow derived macrophages (BMDMs) and J774A.1 cells.	iiim-941	14-22	NLR family, pyrin domain containing 3	Mus musculus	44-49
34248643-4	2021	We found that IIIM-941 inhibits ATP induced NLRP3 inflammasome by induction of autophagy through AMPK pathway in bone marrow derived macrophages (BMDMs) and J774A.1 cells.	Adenosine Triphosphate	32-35	NLR family, pyrin domain containing 3	Mus musculus	44-49
34248643-6	2021	The anti-NLRP3 activity of IIIM-941 was significantly reversed when we attempted to block autophagy by using either pharmacological inhibitor bafilomycin A1or by using siRNA against AMPK.	bafilomycin	142-153	NLR family, pyrin domain containing 3	Mus musculus	9-14
34248643-8	2021	We validated inhibitory activity of IIIM-941 against NLRP3 in three different mice models.	iiim-941	36-44	NLR family, pyrin domain containing 3	Mus musculus	53-58
34248643-12	2021	The compounds like IIIM-941 can be explored further for the development of therapies against diseases such as Alzheimer"s disease and Parkinson"s disease, where hampered autophagy and NLRP3 activation play a crucial role in the pathological development.	iiim-941	19-27	NLR family, pyrin domain containing 3	Mus musculus	184-189
34202695-0	2021	Chrysomycin A Attenuates Neuroinflammation by Down-Regulating NLRP3/Cleaved Caspase-1 Signaling Pathway in LPS-Stimulated Mice and BV2 Cells.	chrysomycin A	0-13	NLR family, pyrin domain containing 3	Mus musculus	62-67
34162415-0	2021	Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice.	divanillyl sulfone	0-18	NLR family, pyrin domain containing 3	Mus musculus	30-35
34162415-8	2021	RESULTS: DS significantly alleviated the neuropathic pain by increasing the mechanical withdrawal threshold and inhibiting the activation of NLRP3 in CCI-induced model mice.	ds	9-11	NLR family, pyrin domain containing 3	Mus musculus	141-146
34162415-8	2021	RESULTS: DS significantly alleviated the neuropathic pain by increasing the mechanical withdrawal threshold and inhibiting the activation of NLRP3 in CCI-induced model mice.	CCI	150-153	NLR family, pyrin domain containing 3	Mus musculus	141-146
34225429-10	2021	Results: Long-term vitamin D deficiency had increased acute liver failure sensitivity in mice, which was manifested by increased blood cell extravasation, massive necrosis of parenchymal cells, up-regulation of TNF-alpha, IL-1beta, and NLRP-3 mRNA expression (P < 0.05), and increased macrophages quantitation (P < 0.05) in liver tissues.	Vitamin D	19-28	NLR family, pyrin domain containing 3	Mus musculus	236-242
34162415-12	2021	CONCLUSION: Together, our findings demonstrated that DS ameliorate chronic neuropathic pain in mice by suppressing NLRP3 inflammasome activation induced by mitophagy in microglia.	ds	53-55	NLR family, pyrin domain containing 3	Mus musculus	115-120
34107901-8	2021	RESULTS: Podocytes treated with palmitic acid (PA) showed downregulated expressions of podocyte markers, increased apoptosis, upregulated levels of NLRP3 inflammasome-related proteins, increased production of inflammatory cytokines (IL-18 and IL-1beta), and induced activation of NF-kappaB as compared to the vehicle-treated controls.	Palmitic Acid	32-45	NLR family, pyrin domain containing 3	Mus musculus	148-153
34207085-4	2021	As the generation of mitochondrial reactive oxidative species (ROS) is a critical upstream event in the activation of NLRP3, we investigated whether anakinra would regulate mitochondrial ROS production.	reactive oxidative species	35-61	NLR family, pyrin domain containing 3	Mus musculus	118-123
34207085-4	2021	As the generation of mitochondrial reactive oxidative species (ROS) is a critical upstream event in the activation of NLRP3, we investigated whether anakinra would regulate mitochondrial ROS production.	ros	63-66	NLR family, pyrin domain containing 3	Mus musculus	118-123
34207356-0	2021	Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-kappaB Signaling Pathway and NLRP3 Inflammasome Activation.	piplartine	21-31	NLR family, pyrin domain containing 3	Mus musculus	121-126
34207356-4	2021	Piplartine also inhibits IL-1beta production and suppresses NLRP3 inflammasome activation by LPS/ATP- and LPS/nigericin-activated macrophages.	piplartine	0-10	NLR family, pyrin domain containing 3	Mus musculus	60-65
34107901-15	2021	CONCLUSIONS: Our study showed that adiponectin ameliorated PA-induced podocyte injury in vitro and HFD-induced injury in vivo via inhibiting the ROS/NF-kappaB/NLRP3 pathway.	ros	145-148	NLR family, pyrin domain containing 3	Mus musculus	159-164
34107901-8	2021	RESULTS: Podocytes treated with palmitic acid (PA) showed downregulated expressions of podocyte markers, increased apoptosis, upregulated levels of NLRP3 inflammasome-related proteins, increased production of inflammatory cytokines (IL-18 and IL-1beta), and induced activation of NF-kappaB as compared to the vehicle-treated controls.	Palmitic Acid	47-49	NLR family, pyrin domain containing 3	Mus musculus	148-153
34114155-0	2021	Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis.	Fatty Acids, Nonesterified	0-15	NLR family, pyrin domain containing 3	Mus musculus	44-49
34114155-12	2021	Free fatty acid can trigger macrophages inflammation through NLRP3-caspase1.	Fatty Acids, Nonesterified	0-15	NLR family, pyrin domain containing 3	Mus musculus	61-66
34114155-17	2021	Free fatty acid generated via adipocyte lipolysis worsens inflammation in adipose tissue macrophages and the outcome of severe acute pancreatitis in obese mice through the NLRP3-caspase1 inflammasome pathway.	Fatty Acids, Nonesterified	0-15	NLR family, pyrin domain containing 3	Mus musculus	172-177
34107901-13	2021	The knockout of adiponectin gene by siRNA increased ROS production, resulting in the activation of NLRP3 inflammasome and the phosphorylation of NF-kappaB in podocytes.	ros	52-55	NLR family, pyrin domain containing 3	Mus musculus	99-104
34107901-14	2021	Pyrrolidine dithiocarbamate, an NF-kappaB inhibitor, prevented adiponectin from ameliorating FFA-induced podocyte injury and NLRP3 activation.	pyrrolidine dithiocarbamic acid	0-27	NLR family, pyrin domain containing 3	Mus musculus	125-130
34207886-0	2021	Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177  (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.	dapansutrile	111-123	NLR family, pyrin domain containing 3	Mus musculus	77-82
34207886-2	2021	We proposed that OLT1177  (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI).	dapansutrile	27-39	NLR family, pyrin domain containing 3	Mus musculus	50-55
34220338-5	2021	E2 significantly decreases RAW 264.7 cell inflammation response by downregulating the expression of NLRP3.	Estradiol	0-2	NLR family, pyrin domain containing 3	Mus musculus	100-105
34311526-5	2021	Following LPS/PS treatment, curcumin (oral, 100 mg/kg; a potent NLRP3 modulator) was administered for 2 weeks in the curcumin treatment group, and normal saline was used for the sham group.	Curcumin	28-36	NLR family, pyrin domain containing 3	Mus musculus	64-69
34220338-11	2021	In summary, miR-29a-5p upregulation induced by E2 alleviated RAW 264.7 cell inflammation response by aggravating miR-29a-5p repression of NLRP3 expression.	Estradiol	47-49	NLR family, pyrin domain containing 3	Mus musculus	138-143
34220338-12	2021	E2 exerts significant anti-inflammatory efficacy in macrophages by regulating the miR-29a-5p/NLRP3 axis.	Estradiol	0-2	NLR family, pyrin domain containing 3	Mus musculus	93-98
34092246-11	2021	Further analysis identified that butyrate alleviated osteolysis via activating its receptor GPR109A, and thus to suppress the activation of NLRP3 inflammasome triggered by Ti-particles.	Butyrates	33-41	NLR family, pyrin domain containing 3	Mus musculus	140-145
34423275-0	2021	Tetramethoxystilbene Inhibits NLRP3 Inflammasome Assembly via Blocking the Oligomerization of Apoptosis-Associated Speck-like Protein Containing Caspase Recruitment Domain: In Vitro and In Vivo Evaluation.	tetramethoxystilbene	0-20	NLR family, pyrin domain containing 3	Mus musculus	30-35
34423275-1	2021	Nucleotide-binding domain leucine-rich repeat family pyrin domain containing 3 (NLRP3) inflammasome complex regulates the caspase-1 activity and subsequent processing of interleukin-1beta (IL-1beta).	Leucine	26-33	NLR family, pyrin domain containing 3	Mus musculus	80-85
34423275-3	2021	The structure-guided design and synthesis of a series of methoxystilbenes and methoxy-2-phenylnaphthalenes identified new inhibitors of NLRP3 inflammasome complex.	methoxystilbenes	57-73	NLR family, pyrin domain containing 3	Mus musculus	136-141
34423275-3	2021	The structure-guided design and synthesis of a series of methoxystilbenes and methoxy-2-phenylnaphthalenes identified new inhibitors of NLRP3 inflammasome complex.	methoxy-2-phenylnaphthalenes	78-106	NLR family, pyrin domain containing 3	Mus musculus	136-141
34423275-5	2021	Mechanistic investigation revealed that tetramethoxystilbene 4o blocks the oligomerization of apoptosis-associated speck-like protein (ASC), which is the vital step in the formation of NLRP3 inflammasome assembly, thus preventing the activation of caspase-1 and the IL-1beta release.	tetramethoxystilbene	40-60	NLR family, pyrin domain containing 3	Mus musculus	185-190
34094640-11	2021	Furthermore, we demonstrated that sterol-resistant SCAP overexpression in VSMCs promoted SCAP and NLRP3 inflammasome cotranslocation to the Golgi and increased the activation of the NLRP3 inflammasome pathway.	Sterols	34-40	NLR family, pyrin domain containing 3	Mus musculus	98-103
34094640-11	2021	Furthermore, we demonstrated that sterol-resistant SCAP overexpression in VSMCs promoted SCAP and NLRP3 inflammasome cotranslocation to the Golgi and increased the activation of the NLRP3 inflammasome pathway.	Sterols	34-40	NLR family, pyrin domain containing 3	Mus musculus	182-187
34094640-12	2021	These findings suggested that sterol-resistant SCAP in VSMCs of mice induced vascular inflammation and endothelial dysfunction, consequently accelerating atherosclerosis by activating the NLRP3 inflammasome pathway.	Sterols	30-36	NLR family, pyrin domain containing 3	Mus musculus	188-193
34103482-1	2021	The purpose of the present study was to investigate whether catalpol exhibited neuroprotective effects in chronic unpredictable mild stress (CUMS) mice through oxidative stress-mediated nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin-domain-containing 3 (NLRP3) inflammasome and neuroinflammation.	catalpol	60-68	NLR family, pyrin domain containing 3	Mus musculus	281-286
34103482-4	2021	We found that the defects of behavioral tests induced by CUMS could be reversed by the absence of NLRP3 and NLRP3 inflammasome might be involved in the antidepressant effects of catalpol on CUMS mice.	catalpol	178-186	NLR family, pyrin domain containing 3	Mus musculus	98-103
34103482-4	2021	We found that the defects of behavioral tests induced by CUMS could be reversed by the absence of NLRP3 and NLRP3 inflammasome might be involved in the antidepressant effects of catalpol on CUMS mice.	catalpol	178-186	NLR family, pyrin domain containing 3	Mus musculus	108-113
34103482-8	2021	Taken together, we provided evidence that catalpol exhibited antidepressive effects on CUMS mice possibly via the oxidative stress-mediated regulation of NLRP3 and neuroinflammation.	catalpol	42-50	NLR family, pyrin domain containing 3	Mus musculus	154-159
34311526-8	2021	Results revealed that the repeated instillation of LPS/PS leads to voiding dysfunction, bladder urothelium denudation, and detrusor muscle fibrosis through the upregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway and the increased epithelial-mesenchymal transition process in bladder tissues.	Phosphorus	55-57	NLR family, pyrin domain containing 3	Mus musculus	180-185
34311526-9	2021	The downregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway in bladder tissues through curcumin effectively mitigated bladder injury in the LPS/PS model.	Curcumin	111-119	NLR family, pyrin domain containing 3	Mus musculus	26-31
34311526-9	2021	The downregulation of the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway in bladder tissues through curcumin effectively mitigated bladder injury in the LPS/PS model.	Phosphorus	168-170	NLR family, pyrin domain containing 3	Mus musculus	26-31
34311526-10	2021	In conclusion, the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway plays a crucial role in bladder injury in the LPS/PS model, and modulation of this pathway, such as by using curcumin, can effectively mitigate the sequelae of chronic inflammation-induced IC/BPS.	Phosphorus	127-129	NLR family, pyrin domain containing 3	Mus musculus	19-24
34311526-10	2021	In conclusion, the NLRP3 inflammasome/IL-1beta-related TGF-beta/Smad pathway plays a crucial role in bladder injury in the LPS/PS model, and modulation of this pathway, such as by using curcumin, can effectively mitigate the sequelae of chronic inflammation-induced IC/BPS.	Curcumin	186-194	NLR family, pyrin domain containing 3	Mus musculus	19-24
34095879-8	2021	The protective, anti-inflammatory effects of itaconate are mediated via activation of NRF2/HO-1 signaling and inhibition of NLRP3 inflammasome.	itaconic acid	45-54	NLR family, pyrin domain containing 3	Mus musculus	124-129
34156680-11	2021	Intraperitoneal injection 30 mg/kg of TEPP-46 significantly inhibited the development of MCD diet-induced NASH, alleviated the pathological changes in the liver, improved liver function, promoted the expression of the PKM2 tetramer in KCs, and inhibited the expression of HIF-1alpha and NLRP3.	TEPP-46	38-45	NLR family, pyrin domain containing 3	Mus musculus	287-292
34103962-0	2021	Mangiferin Mitigates Lipopolysaccharide-Induced Lung Injury by Inhibiting NLRP3 Inflammasome Activation.	mangiferin	0-10	NLR family, pyrin domain containing 3	Mus musculus	74-79
34188608-0	2021	Sodium Houttuyfonate Ameliorates beta-amyloid1-42-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer"s Disease.	sodium houttuyfonate	0-20	NLR family, pyrin domain containing 3	Mus musculus	121-126
34079326-6	2021	In addition to this, EAPP-2 significantly down-regulates the expression of NF-kappaB, p-NF-kappaB, and NLRP3 in vivo and in vitro.	eapp-2	21-27	NLR family, pyrin domain containing 3	Mus musculus	103-108
34079326-7	2021	Moreover, by using specific inhibitors in vitro, it was validated that EAPP-2 targeted on Syk and then regulated its downstream NF-kappaB and NLRP3.	eapp-2	71-77	NLR family, pyrin domain containing 3	Mus musculus	142-147
34079326-8	2021	Conclusion: EAPP-2 is shown to be a potentially useful therapeutic candidate for ACO, and its mechanism is at least partially achieved by targeting on Syk and then inhibiting NF-kappaB or NLRP3.	eapp-2	12-18	NLR family, pyrin domain containing 3	Mus musculus	188-193
34641747-1	2021	AIMS: To explore the role of nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome in ambient fine particulate matter (PM2.5)-related metabolic disorders.	Leucine	59-66	NLR family, pyrin domain containing 3	Mus musculus	90-95
34079457-8	2021	Thus, this study demonstrated that DEX reduced NLRP3-mediated inflammation through the activation of the ubiquitin-autophagy pathway.	Dexmedetomidine	35-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
34079457-11	2021	The anti-inflammatory effect of DEX was explored in vivo by detecting NLRP3-CASP1/IL-1beta protein expression and behavioral testing.	Dexmedetomidine	32-35	NLR family, pyrin domain containing 3	Mus musculus	70-75
34079457-13	2021	Meanwhile, Co-immunoprecipitation (Co-IP) was used to detect NLRP3 protein ubiquitination so as to clarify the new mechanism underlying the anti-inflammatory effect of DEX.	Dexmedetomidine	168-171	NLR family, pyrin domain containing 3	Mus musculus	61-66
34079457-14	2021	Results: Pre-administration of DEX reduced the protein expression of NLRP3, CASP1, and IL-1beta in the hippocampus of mice induced by surgery and also improved the impairment of learning and memory ability.	Dexmedetomidine	31-34	NLR family, pyrin domain containing 3	Mus musculus	69-74
34079457-16	2021	DEX decreased the cleaved CASP1 expression, blocked the assembly of NLRP3-PYCARD-CASP1 complex, and also reduced the secretion of mature IL-1beta in vitro.	Dexmedetomidine	0-3	NLR family, pyrin domain containing 3	Mus musculus	68-73
34079457-17	2021	Mechanically, it accelerated the degradation of NLRP3 inflammasome via the autophagy-ubiquitin pathway and reduced the green fluorescent protein/red fluorescent protein MAP1LC3B ratio, which was comparable to the effect when using the autophagy activator rapamycin (Rapa).	Sirolimus	255-264	NLR family, pyrin domain containing 3	Mus musculus	48-53
34079457-17	2021	Mechanically, it accelerated the degradation of NLRP3 inflammasome via the autophagy-ubiquitin pathway and reduced the green fluorescent protein/red fluorescent protein MAP1LC3B ratio, which was comparable to the effect when using the autophagy activator rapamycin (Rapa).	Sirolimus	266-270	NLR family, pyrin domain containing 3	Mus musculus	48-53
34079457-18	2021	Furthermore, it increased the ubiquitination of NLRP3 after LPS plus ATP stimulated microglia.	Adenosine Triphosphate	69-72	NLR family, pyrin domain containing 3	Mus musculus	48-53
34079457-19	2021	Conclusion: DEX attenuated the hippocampal brain inflammation by promoting NLRP3 inflammasome degradation via the autophagy-ubiquitin pathway, thus improving cognitive impairment in mice.	Dexmedetomidine	12-15	NLR family, pyrin domain containing 3	Mus musculus	75-80
34079466-0	2021	A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression.	Biflavonoids	11-22	NLR family, pyrin domain containing 3	Mus musculus	93-98
34079466-4	2021	Purpose: We aimed to investigate the flavonoid extract (TF) and AM"s effects on NLRP3 inflammasome in vitro and their preventive effects on gout in vivo.	Flavonoids	37-46	NLR family, pyrin domain containing 3	Mus musculus	80-85
34079457-0	2021	Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice.	Dexmedetomidine	0-15	NLR family, pyrin domain containing 3	Mus musculus	26-31
34079457-5	2021	The present study showed that DEX reduced the production of cleaved caspase1 (CASP1) and destroyed the NLRP3-PYD And CARD Domain Containing (PYCARD)-CASP1 complex assembly, thereby reducing the secretion of IL-1beta interleukin beta (IL-1beta).	Dexmedetomidine	30-33	NLR family, pyrin domain containing 3	Mus musculus	103-108
34079457-6	2021	DEX promoted the autophagy process of microglia and reduced NLRP3 expression.	Dexmedetomidine	0-3	NLR family, pyrin domain containing 3	Mus musculus	60-65
34641747-5	2021	The levels of NLRP3-related circulatory inflammatory cytokines including both interleukin (IL)-18 and IL-1beta in serum were increased in the PM2.5-exposed mice and accompanied by the elevation in fasting blood glucose and insulin.	Glucose	211-218	NLR family, pyrin domain containing 3	Mus musculus	14-19
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	177-182
34279193-9	2021	Inhibition assay using specific inhibitors indicated that the treatment of glucose (35 mM/L for 12h) could stimulate NLRP3 inflammasome activation via ROS/JNK MAPKs/NF-kappaB pathway.	Glucose	75-82	NLR family, pyrin domain containing 3	Mus musculus	117-122
34279193-10	2021	In STZ induced diabetes mice models, microglia NLRP3, ASC, and caspase-1 proteins were highly expressed, and serum cytokines IL-1beta, IL6, IL18, and TNFalpha were remarkably increased.	Streptozocin	3-6	NLR family, pyrin domain containing 3	Mus musculus	47-52
34530693-0	2021	Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis.	ursolic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	56-61
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	214-216	NLR family, pyrin domain containing 3	Mus musculus	177-182
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	50-62	NLR family, pyrin domain containing 3	Mus musculus	115-120
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	64-66	NLR family, pyrin domain containing 3	Mus musculus	115-120
34530693-7	2021	Even after CCI4 injection, liver damage and fibrosis-related factors were significantly decreased in NLRP3-/-, NOX4-/-, and AP-treated mice.	cci4	11-15	NLR family, pyrin domain containing 3	Mus musculus	101-106
34219728-10	2021	RESULTS: We found that inhibition of NLRP3 inflammasome with JC124 significantly decreased multiple AD pathologies in APP/PS1 mice, including amyloid-beta (Abeta) load, neuroinflammation, and neuronal cell cycle re-entry, accompanied by preserved synaptic plasticity with higher expression of pre- and post-synaptic proteins, increased hippocampal neurogenesis, and improved cognitive functions.	JC124	61-66	NLR family, pyrin domain containing 3	Mus musculus	37-42
34399601-0	2021	Melatonin ameliorates hepatic steatosis by inhibiting NLRP3 inflammasome in db/db mice.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	54-59
34399601-15	2021	The mRNA levels of the NLRP3 inflammasome could also be remarkably reversed by melatonin in the liver tissues.	Melatonin	79-88	NLR family, pyrin domain containing 3	Mus musculus	23-28
34399601-18	2021	CONCLUSION: Our study concluded that melatonin could safeguard against NAFLD by improving hepatic steatosis in db/db mice, and this action could be associated with the regulation of the NLRP3 inflammasome activation.	Melatonin	37-46	NLR family, pyrin domain containing 3	Mus musculus	186-191
35413363-7	2022	Additionally, co-exposure of As and PSNPs induced pyroptosis in the liver through NLRP3/Caspase-1 pathway via targeting NLRP3, ASC, Pro-Caspase-1, GSDMD and Cleaved-Caspase-1 expressions.	Arsenic	29-31	NLR family, pyrin domain containing 3	Mus musculus	82-87
35397273-3	2022	BSDF-1 administration significantly reduced colonic pathological damage, inhibited the activation of inflammatory signaling pathways, including nuclear factor-kappa B and NLR family pyrin domain containing 3 inflammasomes pathways.	bsdf-1	0-6	NLR family, pyrin domain containing 3	Mus musculus	171-207
35413363-7	2022	Additionally, co-exposure of As and PSNPs induced pyroptosis in the liver through NLRP3/Caspase-1 pathway via targeting NLRP3, ASC, Pro-Caspase-1, GSDMD and Cleaved-Caspase-1 expressions.	Arsenic	29-31	NLR family, pyrin domain containing 3	Mus musculus	120-125
35436667-0	2022	Synthesis and pharmacological validation of fluorescent diarylsulfonylurea analogues as NLRP3 inhibitors and imaging probes.	diarylsulfonylurea	56-74	NLR family, pyrin domain containing 3	Mus musculus	88-93
35405220-7	2022	Males also showed a broad range of anxiogenic responses to PS nanoparticles while hippocampal samples from treated females showed an increased expression of Bax and Nlrp3 genes, indicating a pro-apoptotic/proinflammatory effect of PS treatment.	Polystyrenes	59-61	NLR family, pyrin domain containing 3	Mus musculus	165-170
35405220-7	2022	Males also showed a broad range of anxiogenic responses to PS nanoparticles while hippocampal samples from treated females showed an increased expression of Bax and Nlrp3 genes, indicating a pro-apoptotic/proinflammatory effect of PS treatment.	Polystyrenes	231-233	NLR family, pyrin domain containing 3	Mus musculus	165-170
35436667-5	2022	Herein, we reported a series of diarylsulfonylurea NLRP3 fluorescent inhibitors bearing an amino benzodiazole fluorophore.	diarylsulfonylurea	32-50	NLR family, pyrin domain containing 3	Mus musculus	51-56
35436667-5	2022	Herein, we reported a series of diarylsulfonylurea NLRP3 fluorescent inhibitors bearing an amino benzodiazole fluorophore.	amino benzodiazole	91-109	NLR family, pyrin domain containing 3	Mus musculus	51-56
35436667-7	2022	Among this series, compound 13a exhibited the most potent cellular NLRP3 inhibitory effect with an IC50 value of 49 nM, and significantly suppressed LPS/Nigericin-induced secretion of active caspase-1 and mature IL-1beta in a dose-dependent manner to block the activation of NLRP3 inflammasome.	Nigericin	153-162	NLR family, pyrin domain containing 3	Mus musculus	275-280
35567986-0	2022	Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-kappaB and NLRP3 inflammasome pathway.	Proanthocyanidins	0-12	NLR family, pyrin domain containing 3	Mus musculus	152-157
35537548-0	2022	Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	97-102
35537548-0	2022	Melatonin relieves liver fibrosis induced by Txnrd3 knockdown and nickel exposure via IRE1/NF-kB/NLRP3 and PERK/TGF-beta1 axis activation.	Nickel	66-72	NLR family, pyrin domain containing 3	Mus musculus	97-102
35567986-10	2022	Mechanistically, PA treatment suppressed the nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation and nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome activation.	Proanthocyanidins	17-19	NLR family, pyrin domain containing 3	Mus musculus	109-158
35278280-0	2022	Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-kappaB/NLRP3 signaling pathway in C57BL/6 mice.	Hydrogen	0-8	NLR family, pyrin domain containing 3	Mus musculus	116-121
35567986-10	2022	Mechanistically, PA treatment suppressed the nuclear factor-kappaB (NF-kappaB) p65 nuclear translocation and nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome activation.	Proanthocyanidins	17-19	NLR family, pyrin domain containing 3	Mus musculus	160-165
35567986-11	2022	In vitro studies, 4-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl) propionic acid, main intestinal flora metabolites of PA restrained NF-kappaB/NLRP3 activation.	4-hydroxyphenylacetic acid	18-44	NLR family, pyrin domain containing 3	Mus musculus	146-151
35567986-11	2022	In vitro studies, 4-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl) propionic acid, main intestinal flora metabolites of PA restrained NF-kappaB/NLRP3 activation.	phloretic acid	49-83	NLR family, pyrin domain containing 3	Mus musculus	146-151
35567986-11	2022	In vitro studies, 4-hydroxyphenylacetic acid and 3-(4-hydroxyphenyl) propionic acid, main intestinal flora metabolites of PA restrained NF-kappaB/NLRP3 activation.	Proanthocyanidins	122-124	NLR family, pyrin domain containing 3	Mus musculus	146-151
35567986-12	2022	In conclusions, PA improved IR via NF-kappaB/NLRP3 pathway in GDM and postpartum mice, which partly through its metabolites by gut microbiome.	Proanthocyanidins	16-18	NLR family, pyrin domain containing 3	Mus musculus	45-50
35278280-0	2022	Hydrogen-rich and hyperoxygenate saline inhibits lipopolysaccharide-induced lung injury through mediating NF-kappaB/NLRP3 signaling pathway in C57BL/6 mice.	Sodium Chloride	33-39	NLR family, pyrin domain containing 3	Mus musculus	116-121
35489388-7	2022	RV fractional shortening was also markedly reduced following EwH in WT and NLRP3-/- mice.	SM1-71	61-64	NLR family, pyrin domain containing 3	Mus musculus	75-80
35353387-9	2022	Overall, these data suggest that THIK-1 is a regulator of NLRP3 inflammasome activation in response to ATP and identify THIK-1 as a potential therapeutic target for inflammatory disease.	Adenosine Triphosphate	103-106	NLR family, pyrin domain containing 3	Mus musculus	58-63
35353387-3	2022	A commonly reported mechanism contributing to NLRP3 inflammasome activation is potassium ion (K+ ) efflux across the plasma membrane.	Potassium	79-88	NLR family, pyrin domain containing 3	Mus musculus	46-51
35353387-8	2022	Similarly, BMDMs and microglia from THIK-1 KO mice had reduced NLRP3-dependent IL-1beta release in response to P2X7 receptor activation with ATP.	Adenosine Triphosphate	141-144	NLR family, pyrin domain containing 3	Mus musculus	63-68
35489388-11	2022	In conclusion, EC aerosol exposure following EwH or EwoH induced differential cardiopulmonary remodeling and CARD9 innate immune response and NLRP3 inflammasome contributed to the adverse effects.	ewoh	52-56	NLR family, pyrin domain containing 3	Mus musculus	142-147
35633614-4	2022	Here, we aimed to investigate the inhibitory effect and molecular mechanism of tCQA on IR-induced NLRP3 inflammasome activation.	tcqa	79-83	NLR family, pyrin domain containing 3	Mus musculus	98-103
35633614-10	2022	Finally, THP-1 macrophages and BALB/c mice were irradiated with 137Cs gamma-rays and tCQA could inhibit IR-induced NLRP3 inflammasome activation both in vitro and in vivo.	tcqa	85-89	NLR family, pyrin domain containing 3	Mus musculus	115-120
35633614-11	2022	To conclude, tCQA controls inflammation and NLRP3 inflammasome activation in vitro via NF-kappaB/MAPK signaling pathway and autophagy, meanwhile inhibits IR-induced NLRP3 inflammasome activation in vivo.	tcqa	13-17	NLR family, pyrin domain containing 3	Mus musculus	44-49
35633614-11	2022	To conclude, tCQA controls inflammation and NLRP3 inflammasome activation in vitro via NF-kappaB/MAPK signaling pathway and autophagy, meanwhile inhibits IR-induced NLRP3 inflammasome activation in vivo.	tcqa	13-17	NLR family, pyrin domain containing 3	Mus musculus	165-170
35307576-10	2022	Mechanistically, BBD inhibited both the NF-kappaB pathway and the assembly of NLRP3 complex in PMs.	5-tert-butyl-1,3-benzodioxole	17-20	NLR family, pyrin domain containing 3	Mus musculus	78-83
35533609-3	2022	Endothelial calcium signalling plays a crucial role in both the activation of NLRP3 inflammasome and endothelial cells dysfunction.	Calcium	12-19	NLR family, pyrin domain containing 3	Mus musculus	78-83
35533609-4	2022	However, the efficacy of BBR on the endothelial NLRP3 inflammasome in inflammatory vascular injury remains unknown.	bbr	25-28	NLR family, pyrin domain containing 3	Mus musculus	48-53
35533609-12	2022	Further analysis demonstrated that BBR treatment suppressed the binding of TXNIP (thioredoxin interacting protein) with NLRP3.	bbr	35-38	NLR family, pyrin domain containing 3	Mus musculus	120-125
35307576-0	2022	The Chinese medicine babaodan suppresses LPS-induced sepsis by inhibiting NLRP3-mediated inflammasome activation.	babaodan	21-29	NLR family, pyrin domain containing 3	Mus musculus	74-79
35307576-14	2022	The bile acids and saponins are most likely related to the anti-NLRP3 inflammasome activation effect of BBD.	Bile Acids and Salts	4-14	NLR family, pyrin domain containing 3	Mus musculus	64-69
35307576-14	2022	The bile acids and saponins are most likely related to the anti-NLRP3 inflammasome activation effect of BBD.	Saponins	19-27	NLR family, pyrin domain containing 3	Mus musculus	64-69
35307576-14	2022	The bile acids and saponins are most likely related to the anti-NLRP3 inflammasome activation effect of BBD.	5-tert-butyl-1,3-benzodioxole	104-107	NLR family, pyrin domain containing 3	Mus musculus	64-69
35512472-9	2022	Moreover, ambient PM exposure activated the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome and increased the inflammatory response, as indicated by the increases in interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in the serum and kidney, as well as the upregulation of specific renal fibrosis-related markers (transforming growth factor-beta1 and p-Smad2) in the kidney tissues of mice.	Leucine	74-81	NLR family, pyrin domain containing 3	Mus musculus	105-110
35381220-13	2022	However, in the NLRP3-/- mice, diabetes was unable to effectuate these changes, demonstrating that NLRP3-induced inflammation is responsible for UAB symptoms in these mice.	4-methyl-~{N}-(4-phenylbutyl)piperidine-1-carboxamide	145-148	NLR family, pyrin domain containing 3	Mus musculus	99-104
35551047-0	2022	N,N-dimethylformamide-induced acute liver damage is driven by the activation of NLRP3 inflammasome in liver macrophages of mice.	Dimethylformamide	0-21	NLR family, pyrin domain containing 3	Mus musculus	80-85
35551047-6	2022	Interestingly, DMF exposure led to focal necrosis of hepatocytes and NLRP3 inflammasome activation before the onset of obvious liver damage.	Dimethylformamide	15-18	NLR family, pyrin domain containing 3	Mus musculus	69-74
35551047-8	2022	Furthermore, the inactivation of hepatic macrophages by GdCl3 significantly suppressed DMF-induced elevation of serum aminotransferase activities, neutrophile infiltration, and activation of NLRP3 inflammasome in mice liver.	gdcl3	56-61	NLR family, pyrin domain containing 3	Mus musculus	191-196
35551047-8	2022	Furthermore, the inactivation of hepatic macrophages by GdCl3 significantly suppressed DMF-induced elevation of serum aminotransferase activities, neutrophile infiltration, and activation of NLRP3 inflammasome in mice liver.	Dimethylformamide	87-90	NLR family, pyrin domain containing 3	Mus musculus	191-196
35551047-9	2022	Collectively, these results suggest that DMF-induced acute hepatotoxicity may be attributed to the activation of NLRP3 inflammasome in liver macrophages, but not oxidative stress.	Dimethylformamide	41-44	NLR family, pyrin domain containing 3	Mus musculus	113-118
35561751-0	2022	Salidroside attenuates high altitude hypobaric hypoxia-induced brain injury in mice via inhibiting NF-kappaB/NLRP3 pathway.	rhodioloside	0-11	NLR family, pyrin domain containing 3	Mus musculus	109-114
35561751-10	2022	Taken together, these data provided that the inhibited NF-kappaB/NLRP3 pathway by Sal could attenuate HH-induced cerebral oxidative stress injury, inflammatory responses and the blood brain barrier (BBB) damage, attributing to the improved energy metabolism and the microglial phenotype of anti-inflammatory M2.	rhodioloside	82-85	NLR family, pyrin domain containing 3	Mus musculus	65-70
35506641-0	2022	Tectoridin alleviates lipopolysaccharide -induced inflammaion via inhibiting TLR4-NF-kappaB/NLRP3 signaling in vivo and in vitro.	tectoridin	0-10	NLR family, pyrin domain containing 3	Mus musculus	92-97
35421784-0	2022	Ginsenoside Rg1 attenuates LPS-induced chronic renal injury by inhibiting NOX4-NLRP3 signaling in mice.	ginsenoside Rg1	0-15	NLR family, pyrin domain containing 3	Mus musculus	79-84
35462332-0	2022	Astragaloside IV alleviates PM2.5-caused lung toxicity by inhibiting inflammasome-mediated pyroptosis via NLRP3/caspase-1 axis inhibition in mice.	astragaloside	0-13	NLR family, pyrin domain containing 3	Mus musculus	106-111
35462332-5	2022	The investigation was performed with Ast or in combination with nigericin, which is a NOD-like receptor protein 3 (NLRP3) activator.	Nigericin	64-73	NLR family, pyrin domain containing 3	Mus musculus	86-113
35462332-5	2022	The investigation was performed with Ast or in combination with nigericin, which is a NOD-like receptor protein 3 (NLRP3) activator.	Nigericin	64-73	NLR family, pyrin domain containing 3	Mus musculus	115-120
35490491-13	2022	Furthermore, GZFL inhibited the expressions of NLRP3, ASC, and cleaved-Caspase-1, while Nrf2, HO-1, NQO1, GCLM, and tight junction proteins were increased.	gzfl	13-17	NLR family, pyrin domain containing 3	Mus musculus	47-52
35490491-15	2022	CONCLUSIONS: This study showed that GZFL could improve kidney damage, which might be mainly via the integrated regulations of the Nrf2 pathway, NLRP3 inflammasome, and composition of intestinal microbiota.	gzfl	36-40	NLR family, pyrin domain containing 3	Mus musculus	144-149
35428012-0	2022	Discovery of 4-((E)-3,5-dimethoxy-2-((E)-2-nitrovinyl)styryl)aniline derivatives as potent and orally active NLRP3 inflammasome inhibitors for colitis.	4-((e)-3,5-dimethoxy-2-((e)-2-nitrovinyl)styryl)aniline	13-68	NLR family, pyrin domain containing 3	Mus musculus	109-114
35428012-2	2022	Here a series of pterostilbene derivatives were designed and synthesized based on previous SAR, leading to discovery of new effective NLRP3 inflammasome inhibitors with metabolic stability.	pterostilbene	17-30	NLR family, pyrin domain containing 3	Mus musculus	134-139
35506641-10	2022	Furthermore, our results demonstrated that tectoridin inhibited the activation of TLR4-NF-kappaB/NLRP3 signaling proved by immunohistochemistry assay and Western blot.	tectoridin	43-53	NLR family, pyrin domain containing 3	Mus musculus	97-102
35506641-11	2022	CONCLUSION: Taken all together, tectoridin might have the potential ability of anti-inflammatory effects and the possible mechanism may be relevant to its inhibition of TLR4-NF-kappaB/NLRP3 signaling.	tectoridin	32-42	NLR family, pyrin domain containing 3	Mus musculus	184-189
35421784-9	2022	And Rg1 treatment also significantly reduced ROS generation and inhibited the activation of NOX4 and NLRP3 inflammasome.	ginsenoside Rg1	4-7	NLR family, pyrin domain containing 3	Mus musculus	101-106
35431287-0	2022	Carbenoxolone ameliorates allergic airway inflammation through NF-kappaB/NLRP3 pathway in mice.	Carbenoxolone	0-13	NLR family, pyrin domain containing 3	Mus musculus	73-78
35431287-11	2022	In addition, the expression of p-NF-kappaB, p-IkappaB-alpha, NLRP3 and related factors were dramatically alleviated after CBX treatment.	Carbenoxolone	122-125	NLR family, pyrin domain containing 3	Mus musculus	61-66
35431287-12	2022	These data suggest that CBX has a significant protective effect on allergic airway inflammation by suppressing the activation of NLRP3 inflammasome through NF-kappaB pathway in asthmatic mice.	Carbenoxolone	24-27	NLR family, pyrin domain containing 3	Mus musculus	129-134
35489281-8	2022	Analogously, we treated cultured HK-2 cells with a high concentration of glucose (35 mmol/L), which caused these cells to exhibit significantly increased concentrations of reactive oxygen species (ROS), phosphorylated (p)-nuclear factor kappa B (NF-kappaB), p-IkappaB, NLRP3, caspase-1, IL-1beta, and IL-18, and the loss of mitochondrial transmembrane potential.	Glucose	73-80	NLR family, pyrin domain containing 3	Mus musculus	269-274
35156147-13	2022	Captopril, an ACE inhibitor, inhibited NOX4-associated oxidative stress and NLRP3 inflammasome activation in both HG-induced NRCFs and diabetic hearts.	Captopril	0-9	NLR family, pyrin domain containing 3	Mus musculus	76-81
35439615-6	2022	We also found that the expression level of NLRP3-inflammasome and inflammatory cytokines significantly increased in the atria of SP mice, which further increased in application the TRPV4 agonist GSK1016790A (GSK101) and decreased in application the TRPV4 antagonist GSK2193874.	sp	129-131	NLR family, pyrin domain containing 3	Mus musculus	43-48
35439615-6	2022	We also found that the expression level of NLRP3-inflammasome and inflammatory cytokines significantly increased in the atria of SP mice, which further increased in application the TRPV4 agonist GSK1016790A (GSK101) and decreased in application the TRPV4 antagonist GSK2193874.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	195-206	NLR family, pyrin domain containing 3	Mus musculus	43-48
35439615-6	2022	We also found that the expression level of NLRP3-inflammasome and inflammatory cytokines significantly increased in the atria of SP mice, which further increased in application the TRPV4 agonist GSK1016790A (GSK101) and decreased in application the TRPV4 antagonist GSK2193874.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	208-214	NLR family, pyrin domain containing 3	Mus musculus	43-48
35439615-6	2022	We also found that the expression level of NLRP3-inflammasome and inflammatory cytokines significantly increased in the atria of SP mice, which further increased in application the TRPV4 agonist GSK1016790A (GSK101) and decreased in application the TRPV4 antagonist GSK2193874.	GSK2193874	266-276	NLR family, pyrin domain containing 3	Mus musculus	43-48
35439615-7	2022	More importantly, ERK inhibitor (U0126) or NF-kappaB inhibitor (Bay11-7082) could partially reverse GSK101-induced NLRP3-inflammasome up-regulation.	U 0126	33-38	NLR family, pyrin domain containing 3	Mus musculus	115-120
35439615-7	2022	More importantly, ERK inhibitor (U0126) or NF-kappaB inhibitor (Bay11-7082) could partially reverse GSK101-induced NLRP3-inflammasome up-regulation.	3-(4-methylphenylsulfonyl)-2-propenenitrile	64-74	NLR family, pyrin domain containing 3	Mus musculus	115-120
35439615-7	2022	More importantly, ERK inhibitor (U0126) or NF-kappaB inhibitor (Bay11-7082) could partially reverse GSK101-induced NLRP3-inflammasome up-regulation.	N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide	100-106	NLR family, pyrin domain containing 3	Mus musculus	115-120
35439615-9	2022	Finally, we shown that the activation of NLRP3-inflammasome and ERK/NF-kappaB signaling pathway significantly reduced in TRPV4-knockout SP mice.	sp	136-138	NLR family, pyrin domain containing 3	Mus musculus	41-46
35359022-9	2022	These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.	3-methylquercetin	41-53	NLR family, pyrin domain containing 3	Mus musculus	215-220
35359022-0	2022	Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2.	3-methylquercetin	25-37	NLR family, pyrin domain containing 3	Mus musculus	103-108
35359022-0	2022	Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2.	Acetaminophen	48-61	NLR family, pyrin domain containing 3	Mus musculus	103-108
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	NLR family, pyrin domain containing 3	Mus musculus	164-169
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	150-177
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	179-184
35088269-7	2022	Additionally, ACR treatment caused an inflammatory response via nuclear factor-kappa B (NF-kappaB) activation and increased the protein expression of NOD-like receptor protein-3 (NLRP3), consequently activating the NLRP3 inflammasome constituents, including cysteinyl aspartate specific proteinase 1 (Caspase-1), apoptosis-associated speck-like protein containing CARD (ASC), N domain gasdermin D (N-GSDMD), interleukin-1beta (IL-1beta), and IL-18.	Acrylamide	14-17	NLR family, pyrin domain containing 3	Mus musculus	215-220
35297281-0	2022	Isopanepoxydone inhibits oxidative damage in murine alveolar macrophages via NRF2 and NLRP3 inflammasome.	Isopanepoxydone	0-15	NLR family, pyrin domain containing 3	Mus musculus	86-91
35579890-11	2022	Furthermore, CPT in oxygen-glucose deprivation neurons down-regulated Top1 level, attenuated NLRP3 inflammasome activation, and suppressed pyroptosis and inflammatory response.	Oxygen	20-26	NLR family, pyrin domain containing 3	Mus musculus	93-98
34997266-11	2022	CONCLUSION: PQQ improved DCM in diabetic mice by inhibiting NF-kappaB/NLRP3 inflammasome-mediated cell pyroptosis.	PQQ Cofactor	12-15	NLR family, pyrin domain containing 3	Mus musculus	70-75
34997266-14	2022	PQQ inhibits ROS generation and NF-kappaB activation, which stimulates activation of the NLRP3 inflammasome and regulates the expression of caspase-1, IL-1beta, and IL-18.	PQQ Cofactor	0-3	NLR family, pyrin domain containing 3	Mus musculus	89-94
35481558-7	2022	Further mechanistic studies showed that apigenin regulated the NLRP3 inflammasome through two ways, so as to alleviate PA-induced pyroptosis.	Palmitic Acid	119-121	NLR family, pyrin domain containing 3	Mus musculus	63-68
35434787-10	2022	dMCAO increased the NLRP3 expression and enhanced caspase 1 activity.	dmcao	0-5	NLR family, pyrin domain containing 3	Mus musculus	20-25
35367811-6	2022	XBP1 deficiency increased ROS production to promote hepatocellular pyroptosis by activating NLRP3/caspase-1/GSDMD signaling, which facilitated the extracellular release of mtDNA.	ros	26-29	NLR family, pyrin domain containing 3	Mus musculus	92-97
35622000-4	2022	The transplantation of Nlrp3-/- islets or WT islets exposed to the NLRP3 inhibitor CY-09 into mouse dorsal skinfold chambers resulted in an improved revascularization when compared to controls.	CY5.5 cyanine dye	83-88	NLR family, pyrin domain containing 3	Mus musculus	23-28
35622000-4	2022	The transplantation of Nlrp3-/- islets or WT islets exposed to the NLRP3 inhibitor CY-09 into mouse dorsal skinfold chambers resulted in an improved revascularization when compared to controls.	CY5.5 cyanine dye	83-88	NLR family, pyrin domain containing 3	Mus musculus	67-72
35364735-14	2022	Dorsomorphin pre-administration indicated a possible interplay between AMPK/SIRT1 and NLRP3 inflammasome activation as it partially reversed liraglutide"s effects.	dorsomorphin	0-12	NLR family, pyrin domain containing 3	Mus musculus	86-91
35338958-0	2022	ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.	N-acetylmannosamine	0-6	NLR family, pyrin domain containing 3	Mus musculus	88-93
35338958-0	2022	ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model.	Reactive Oxygen Species	84-87	NLR family, pyrin domain containing 3	Mus musculus	88-93
35338958-10	2022	In addition, ManNAc administration attenuated podocyte cell death and suppressed the activation of Nucleotide leukin-rich polypeptide 3 (NLRP3), caspase-1, and interleukin-1beta (IL-1beta), and the cleavage of gasdermin-D (GSDMD).	N-acetylmannosamine	13-19	NLR family, pyrin domain containing 3	Mus musculus	99-135
35338958-10	2022	In addition, ManNAc administration attenuated podocyte cell death and suppressed the activation of Nucleotide leukin-rich polypeptide 3 (NLRP3), caspase-1, and interleukin-1beta (IL-1beta), and the cleavage of gasdermin-D (GSDMD).	N-acetylmannosamine	13-19	NLR family, pyrin domain containing 3	Mus musculus	137-142
35338958-12	2022	Further, ManNAc administration significantly alleviated podocyte pyroptosis through inhibiting ROS/NLRP3 signaling pathway.	N-acetylmannosamine	9-15	NLR family, pyrin domain containing 3	Mus musculus	99-104
35338958-12	2022	Further, ManNAc administration significantly alleviated podocyte pyroptosis through inhibiting ROS/NLRP3 signaling pathway.	Reactive Oxygen Species	95-98	NLR family, pyrin domain containing 3	Mus musculus	99-104
35338958-13	2022	Therefore, these results elucidated that the upregulated expression of Angptl4 was involved in podocyte injury and ManNAc treatment protected against podocyte pyroptosis via inhibiting mitochondrial injury and ROS/NLRP3 signaling pathway in DN mice.	N-acetylmannosamine	115-121	NLR family, pyrin domain containing 3	Mus musculus	214-219
35338958-13	2022	Therefore, these results elucidated that the upregulated expression of Angptl4 was involved in podocyte injury and ManNAc treatment protected against podocyte pyroptosis via inhibiting mitochondrial injury and ROS/NLRP3 signaling pathway in DN mice.	Reactive Oxygen Species	210-213	NLR family, pyrin domain containing 3	Mus musculus	214-219
35338961-7	2022	Western blot results showed that TBHQ treatment inhibited the protein expression of NLRP3, Caspase-1, IL-1beta, and IL-18, which induced by LPS.	2-tert-butylhydroquinone	33-37	NLR family, pyrin domain containing 3	Mus musculus	84-89
35338961-9	2022	These results suggested that, by inhibiting LPS-induced neuroinflammation and microglia activation, TBHQ could effectively improve LPS-induced inflammation-related depression-like behavior through modulating the NLRP3 signaling pathway.	2-tert-butylhydroquinone	100-104	NLR family, pyrin domain containing 3	Mus musculus	212-217
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	201-223	NLR family, pyrin domain containing 3	Mus musculus	23-42
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	201-223	NLR family, pyrin domain containing 3	Mus musculus	44-49
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	201-223	NLR family, pyrin domain containing 3	Mus musculus	104-109
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	225-228	NLR family, pyrin domain containing 3	Mus musculus	23-42
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	225-228	NLR family, pyrin domain containing 3	Mus musculus	44-49
35447415-2	2022	In our previous study, NOD-like receptor 3 (NLRP3) inflammasome activation requiring the interaction of NLRP3 with NIMA Related Kinase 7 (NEK7) had been reported to regulate MODE-K cell pyroptosis and dextran sulfate sodium (DSS)-induced murine colitis.	Dextran Sulfate	225-228	NLR family, pyrin domain containing 3	Mus musculus	104-109
35462079-0	2022	Maresin-2 alleviates allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome, Th2 type immune response and oxidative stress.	13,14-dihydroxydocosahexaenoic acid	0-9	NLR family, pyrin domain containing 3	Mus musculus	90-95
35413645-0	2022	Gegen Qinlian pills alleviate carrageenan-induced thrombosis in mice model by regulating the HMGB1/NF-kappaB/NLRP3 signaling.	Carrageenan	30-41	NLR family, pyrin domain containing 3	Mus musculus	109-114
35620829-0	2022	Isoquercetin alleviates sleep deprivation dependent hippocampal neurons damage by suppressing NLRP3-induced pyroptosis.	isoquercitrin	0-12	NLR family, pyrin domain containing 3	Mus musculus	94-99
35620829-10	2022	Moreover, SD upregulated NLRP3 level, which was downregulated by isoquercetin.	isoquercitrin	65-77	NLR family, pyrin domain containing 3	Mus musculus	25-30
35620829-11	2022	Additionally, isoquercetin rescued the increase of pyroptosis and the upregulation of NLRP3, caspase-1, ASC, IL-1beta, IL-18, and GSDMD levels induced by LPS.	isoquercitrin	14-26	NLR family, pyrin domain containing 3	Mus musculus	86-91
35620829-12	2022	In conclusion, isoquercetin improved learning and cognitive capability of SD mice via suppressing NLRP3-induced pyroptosis of hippocampal neurons cells, suggesting that isoquercetin might be an efficacious drug for memory disorders caused by SD.	isoquercitrin	15-27	NLR family, pyrin domain containing 3	Mus musculus	98-103
35620829-12	2022	In conclusion, isoquercetin improved learning and cognitive capability of SD mice via suppressing NLRP3-induced pyroptosis of hippocampal neurons cells, suggesting that isoquercetin might be an efficacious drug for memory disorders caused by SD.	isoquercitrin	169-181	NLR family, pyrin domain containing 3	Mus musculus	98-103
35605433-0	2022	Dimethyl fumarate ameliorates autoimmune hepatitis in mice by blocking NLRP3 inflammasome activation.	Dimethyl Fumarate	0-17	NLR family, pyrin domain containing 3	Mus musculus	71-76
35605433-3	2022	In this study, we aimed to explore whether DMF affects auto-immune hepatitis (AIH) in mice induced by concanavalin A (Con A) by modulating NLRP3 inflammasome activation.	Dimethyl Fumarate	43-46	NLR family, pyrin domain containing 3	Mus musculus	139-144
35605433-4	2022	The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT).	Nigericin	167-176	NLR family, pyrin domain containing 3	Mus musculus	57-62
35605433-4	2022	The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT).	Dimethyl Fumarate	24-27	NLR family, pyrin domain containing 3	Mus musculus	57-62
35605433-5	2022	DMF also greatly reduced ASC speck formation upon the stimulation of nigericin or ATP, indicating its inhibitory effect on NLRP3 inflammasome assembly.	Dimethyl Fumarate	0-3	NLR family, pyrin domain containing 3	Mus musculus	123-128
35605433-5	2022	DMF also greatly reduced ASC speck formation upon the stimulation of nigericin or ATP, indicating its inhibitory effect on NLRP3 inflammasome assembly.	Nigericin	69-78	NLR family, pyrin domain containing 3	Mus musculus	123-128
35605433-5	2022	DMF also greatly reduced ASC speck formation upon the stimulation of nigericin or ATP, indicating its inhibitory effect on NLRP3 inflammasome assembly.	Adenosine Triphosphate	82-85	NLR family, pyrin domain containing 3	Mus musculus	123-128
35605433-4	2022	The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT).	Adenosine Triphosphate	160-163	NLR family, pyrin domain containing 3	Mus musculus	57-62
35605433-11	2022	Collectively, DMF displayed anti-inflammatory effects by inhibiting NLRP3 inflammasome activation likely through regulating PKA signaling, highlighting its potential application in treating AIH.	Dimethyl Fumarate	14-17	NLR family, pyrin domain containing 3	Mus musculus	68-73
35598657-0	2022	Epimedin A ameliorates DNFB-induced allergic contact dermatitis in mice: Role of NF-kappaB/NLRP3-driven pyroptosis, Nrf2/HO-1 pathway, and inflammation modulation.	Dinitrofluorobenzene	23-27	NLR family, pyrin domain containing 3	Mus musculus	91-96
35605435-0	2022	Phytosomal tripterine with selenium modification attenuates the cytotoxicity and restrains the inflammatory evolution via inhibiting NLRP3 inflammasome activation and pyroptosis.	celastrol	11-21	NLR family, pyrin domain containing 3	Mus musculus	133-138
35605435-0	2022	Phytosomal tripterine with selenium modification attenuates the cytotoxicity and restrains the inflammatory evolution via inhibiting NLRP3 inflammasome activation and pyroptosis.	Selenium	27-35	NLR family, pyrin domain containing 3	Mus musculus	133-138
35605435-9	2022	Also, Se@Tri-PTs inhibited the releases of caspase-1p20 and mature IL-1beta, resulting in restriction of NLRP3 inflammasome activation that inhibits the formation of GSDMD-NT whereby to initiate pyroptosis.	Selenium	6-8	NLR family, pyrin domain containing 3	Mus musculus	105-110
35605435-9	2022	Also, Se@Tri-PTs inhibited the releases of caspase-1p20 and mature IL-1beta, resulting in restriction of NLRP3 inflammasome activation that inhibits the formation of GSDMD-NT whereby to initiate pyroptosis.	tri-pts	9-16	NLR family, pyrin domain containing 3	Mus musculus	105-110
35598657-1	2022	AIMS: The present study aimed to investigate the potential of epimedin A to ameliorate DNFB-induced allergic contact dermatitis (CD) and reveal its potential underlying mechanisms of action, emphasizing its role in modulating NF-kappaB/NLRP3, Nrf2/HO-1 pathways, and inflammation.	epimedin A	62-72	NLR family, pyrin domain containing 3	Mus musculus	236-241
35628508-0	2022	An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.	ros	118-121	NLR family, pyrin domain containing 3	Mus musculus	131-136
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	Sirolimus	0-4	NLR family, pyrin domain containing 3	Mus musculus	97-102
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	Sirolimus	0-4	NLR family, pyrin domain containing 3	Mus musculus	215-220
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	97-102
35628508-7	2022	RAPA treatment (an inducer of autophagy) significantly improved realgar-induced liver injury and NLRP3 inflammasome activation, while 3-MA (an inhibitor of autophagy) aggravated the realgar-induced liver injury and NLRP3 inflammasome activation.	3-methyladenine	134-138	NLR family, pyrin domain containing 3	Mus musculus	215-220
35598657-7	2022	SIGNIFICANCE: Epimedin A is a novel, hopeful, natural therapeutic agent for CD by modulating NF-kappaB/NLRP3, Nrf2 pathways, and inflammation.	epimedin A	14-24	NLR family, pyrin domain containing 3	Mus musculus	103-108
35620578-0	2022	Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf--lammasome Activation, and Reversing Gut Microbiota Disorder.	Sitagliptin Phosphate	0-11	NLR family, pyrin domain containing 3	Mus musculus	107-112
35628508-8	2022	Furthermore, we found that realgar-induced NLRP3 inflammasome activation in mouse livers is mediated by ROS.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	43-48
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	Sirolimus	0-4	NLR family, pyrin domain containing 3	Mus musculus	101-106
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	Sirolimus	0-4	NLR family, pyrin domain containing 3	Mus musculus	151-156
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	ros	138-141	NLR family, pyrin domain containing 3	Mus musculus	101-106
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	ros	138-141	NLR family, pyrin domain containing 3	Mus musculus	151-156
35628508-10	2022	In conclusion, the results of this study suggest that autophagy alleviates realgar-induced liver injury by inhibiting ROS-mediated NLRP3 inflammasome activation.	arsenic disulfide	75-82	NLR family, pyrin domain containing 3	Mus musculus	131-136
35628508-10	2022	In conclusion, the results of this study suggest that autophagy alleviates realgar-induced liver injury by inhibiting ROS-mediated NLRP3 inflammasome activation.	ros	118-121	NLR family, pyrin domain containing 3	Mus musculus	131-136
35620578-6	2022	Mechanistically, the radiation protection of Sitagliptin might be related to the upregulation of NRF2 level and the decrease of NLRP3 inflammasome activity.	Sitagliptin Phosphate	45-56	NLR family, pyrin domain containing 3	Mus musculus	128-133
35569032-0	2022	Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing.	ipriflavone	0-11	NLR family, pyrin domain containing 3	Mus musculus	23-28
35575951-0	2022	Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the ulcerative colitis mice through inhibiting the TXNIP-mediated activation of NLRP3 inflammasome.	trifolirhizin	0-13	NLR family, pyrin domain containing 3	Mus musculus	155-160
35575951-7	2022	Further, the activation NLRP3 inflammasome was suppressed by Trifolirhizin in DSS-induced colitis mice.	trifolirhizin	61-74	NLR family, pyrin domain containing 3	Mus musculus	24-29
35575951-7	2022	Further, the activation NLRP3 inflammasome was suppressed by Trifolirhizin in DSS-induced colitis mice.	Dextran Sulfate	78-81	NLR family, pyrin domain containing 3	Mus musculus	24-29
35575951-11	2022	Trifolirhizin regulated the balance of Th17/Treg cells and inflammation in the UC mice through inhibiting the TXNIP-mediated activation of NLRP3 inflammasome.	trifolirhizin	0-13	NLR family, pyrin domain containing 3	Mus musculus	139-144
35157936-5	2022	Mechanistically, PCB138 induced mitochondrial dysfunction and endoplasmic reticulum (ER) stress, which might have led to inflammatory responses, such as activation of the NF-kappaB (nuclear factor kappa-B) and NLRP3 (NOD-like receptor protein 3) pathways.	2,2',3',4,4',5-hexachlorobiphenyl	17-23	NLR family, pyrin domain containing 3	Mus musculus	210-215
35157936-5	2022	Mechanistically, PCB138 induced mitochondrial dysfunction and endoplasmic reticulum (ER) stress, which might have led to inflammatory responses, such as activation of the NF-kappaB (nuclear factor kappa-B) and NLRP3 (NOD-like receptor protein 3) pathways.	2,2',3',4,4',5-hexachlorobiphenyl	17-23	NLR family, pyrin domain containing 3	Mus musculus	217-244
35569032-6	2022	In addition, we explored the mechanism of ipriflavone in the regulation of NLRP3 inflammasome activation in macrophages.	ipriflavone	42-53	NLR family, pyrin domain containing 3	Mus musculus	75-80
35569032-7	2022	RESULTS: In vivo, ipriflavone ameliorated host inflammatory response related to NLRP3 inflammasome activation at implantation sites characterized by reductions of inflammatory cells infiltration and proinflammatory cytokine IL-1beta levels.	ipriflavone	18-29	NLR family, pyrin domain containing 3	Mus musculus	80-85
35569032-9	2022	Further investigations of the molecular mechanism showed that the suppression of NLRP3 inflammasome acts upstream of NLRP3 oligomerization through abrogating the production of reactive oxygen species (ROS).	Reactive Oxygen Species	176-199	NLR family, pyrin domain containing 3	Mus musculus	81-86
35569032-9	2022	Further investigations of the molecular mechanism showed that the suppression of NLRP3 inflammasome acts upstream of NLRP3 oligomerization through abrogating the production of reactive oxygen species (ROS).	Reactive Oxygen Species	176-199	NLR family, pyrin domain containing 3	Mus musculus	117-122
35569032-9	2022	Further investigations of the molecular mechanism showed that the suppression of NLRP3 inflammasome acts upstream of NLRP3 oligomerization through abrogating the production of reactive oxygen species (ROS).	Reactive Oxygen Species	201-204	NLR family, pyrin domain containing 3	Mus musculus	81-86
35569032-9	2022	Further investigations of the molecular mechanism showed that the suppression of NLRP3 inflammasome acts upstream of NLRP3 oligomerization through abrogating the production of reactive oxygen species (ROS).	Reactive Oxygen Species	201-204	NLR family, pyrin domain containing 3	Mus musculus	117-122
35569032-10	2022	CONCLUSION: These results revealed an anti-inflammatory role of ipriflavone in NLRP3 inflammasome activation through improving mitochondrial function.	ipriflavone	64-75	NLR family, pyrin domain containing 3	Mus musculus	79-84
35538059-11	2022	Our study demonstrated that activation of the cGAS-STING pathway caused by mitochondrial oxidative damage and mtDNA escape induced by free fatty acids promoted pyroptosis and proinflammatory responses in cardiomyocytes in a NLRP3 inflammasome-dependent manner, thus promoting myocardial hypertrophy during the progression of DCM.	Fatty Acids, Nonesterified	134-150	NLR family, pyrin domain containing 3	Mus musculus	224-229
35595603-12	2022	CONCLUSION: Our results show that 40-Hz taVNS inhibits the hippocampal P2X7R/NLRP3/Caspase-1 signaling and improves spatial learning and memory in 6-month-old APP/PS1 mice.	tavns	40-45	NLR family, pyrin domain containing 3	Mus musculus	77-82
35568203-5	2022	High glucose culturing conditions increased TLR4 and NLRP3 proteins, which were also increased by TNFAIP3 siRNA.	Glucose	5-12	NLR family, pyrin domain containing 3	Mus musculus	53-58
35545014-9	2022	Mechanistically, catalpol preadministration suppressed the activation of microglia and decreased the expression of NLRP3 inflammasome.	catalpol	17-25	NLR family, pyrin domain containing 3	Mus musculus	115-120
35545014-10	2022	CONCLUSION: Our results indicate that catalpol preadministration could effectively alleviate cognitive impairment and neuropathological damage in isoflurane-exposed aged mice with its neuroprotective effects via modulation of the NLRP3 inflammatory pathway.	catalpol	38-46	NLR family, pyrin domain containing 3	Mus musculus	230-235
35550840-5	2022	Meanwhile, the cell number of TH+/Caspase3+/IBA1+ in substantia nigra, cell viability, and apoptosis rate of BV2 microglia, inflammatory levels, and NLR family pyrin domain containing 3 (NLRP3) inflammasome were determined using immunohistochemistry, MTT assay, flow cytometry, ELISA assay, and Western blot.	monooxyethylene trimethylolpropane tristearate	251-254	NLR family, pyrin domain containing 3	Mus musculus	149-185
35550840-5	2022	Meanwhile, the cell number of TH+/Caspase3+/IBA1+ in substantia nigra, cell viability, and apoptosis rate of BV2 microglia, inflammatory levels, and NLR family pyrin domain containing 3 (NLRP3) inflammasome were determined using immunohistochemistry, MTT assay, flow cytometry, ELISA assay, and Western blot.	monooxyethylene trimethylolpropane tristearate	251-254	NLR family, pyrin domain containing 3	Mus musculus	187-192
35550264-0	2022	Sevoflurane suppresses NLRP3 inflammasome-mediated pyroptotic cell death to attenuate lipopolysaccharide-induced acute lung injury through inducing GSK-3beta phosphorylation and activation.	Sevoflurane	0-11	NLR family, pyrin domain containing 3	Mus musculus	23-28
35533904-12	2022	NLRP3 inhibition attenuated retinal injury of diabetic mice on high salt diet.	Salts	68-72	NLR family, pyrin domain containing 3	Mus musculus	0-5
35533904-15	2022	CONCLUSION: These results indicate that high salt intake has deleterious effects in DR development through NLRP3 inflammasome activation and the subsequent production of IL-1beta.	Salts	45-49	NLR family, pyrin domain containing 3	Mus musculus	107-112
35417750-6	2022	In the P. bovis group, treatment with N-acetyl-l-cysteine (NAC) significantly decreased protein expression in NF-kappaB and the NLRP3 inflammasome pathway, as well as IL-1beta, IL-6 and IL-18, whereas protein expression in the Nrf2 pathway was significantly changed.	Acetylcysteine	38-57	NLR family, pyrin domain containing 3	Mus musculus	128-133
35524333-2	2022	NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) and NLR family pyrin domain containing 6 (NLRP6) expression.	Reactive Oxygen Species	32-55	NLR family, pyrin domain containing 3	Mus musculus	180-185
35524333-2	2022	NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) and NLR family pyrin domain containing 6 (NLRP6) expression.	Reactive Oxygen Species	57-60	NLR family, pyrin domain containing 3	Mus musculus	180-185
35524333-13	2022	GLX351322 reversed the imbalance in NLRP3/NLRP6 by reducing the ROS levels.	GLX351322	0-9	NLR family, pyrin domain containing 3	Mus musculus	36-41
35524333-13	2022	GLX351322 reversed the imbalance in NLRP3/NLRP6 by reducing the ROS levels.	Reactive Oxygen Species	64-67	NLR family, pyrin domain containing 3	Mus musculus	36-41
35524333-28	2022	Eye drops containing GLX351322, a NOX4 inhibitor, reversed the imbalance in NLRP3/NLRP6 by reducing ROS expression.	GLX351322	21-30	NLR family, pyrin domain containing 3	Mus musculus	76-81
35524333-28	2022	Eye drops containing GLX351322, a NOX4 inhibitor, reversed the imbalance in NLRP3/NLRP6 by reducing ROS expression.	Reactive Oxygen Species	100-103	NLR family, pyrin domain containing 3	Mus musculus	76-81
35571243-0	2022	Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-kappaB Signaling Pathway Affects Chondrocyte Pyroptosis.	dietary fatty acid	0-18	NLR family, pyrin domain containing 3	Mus musculus	37-42
35571243-7	2022	Diets rich in n-3 polyunsaturated fatty acids (PUFAs) attenuated OA and inhibited the TLR4/NF-kappaB and NLRP3/caspase-1/GSDMD signaling pathways, whereas diets rich in saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), or n-6 PUFAs increased OA severity and activated these pathways.	Fatty Acids, Unsaturated	47-52	NLR family, pyrin domain containing 3	Mus musculus	105-110
35563469-7	2022	Results: We report here that EMD, like the inflammasome (NLRP3) and CAS1 specific inhibitors-MCC950 and Ac-YVAD-cmk, respectively-lowered the LPS-induced expression of NLRP3 in primary macrophages (EMD: p = 0.0232; MCC950: p = 0.0426; Ac-YVAD-cmk: p = 0.0317).	ac-yvad	104-111	NLR family, pyrin domain containing 3	Mus musculus	168-173
35586062-1	2022	Alkaloid Suppresses NLRP3-Mediated Pyroptosis to Alleviate LPS-Induced Neurotoxicity.	Alkaloids	0-8	NLR family, pyrin domain containing 3	Mus musculus	20-25
35586062-12	2022	Furthermore, DNLA-mediated neuroprotection was dependent on the inhibition of NLRP3 inflammasome activation, as evidenced by the fact that DNLA reduced pro-inflammatory factor (IL-18 and IL-1beta) production and inhibited the expression of related proteins.	dnla	13-17	NLR family, pyrin domain containing 3	Mus musculus	78-83
35586062-12	2022	Furthermore, DNLA-mediated neuroprotection was dependent on the inhibition of NLRP3 inflammasome activation, as evidenced by the fact that DNLA reduced pro-inflammatory factor (IL-18 and IL-1beta) production and inhibited the expression of related proteins.	dnla	139-143	NLR family, pyrin domain containing 3	Mus musculus	78-83
35586062-14	2022	Together, this study suggested that DNLA attenuated NLRP3-mediated pyroptosis to generate neuroprotection against LPS-induced neuronal damage and cognitive impairment.	dnla	36-40	NLR family, pyrin domain containing 3	Mus musculus	52-57
35279552-4	2022	Our data revealed that J-1063 exerted anti-fibrotic activity by inhibiting TGF-betaR1 (ALK5), which is likely related to the inhibition of TGF-beta--Smad signaling and NLRP3 inflammasome activation.	CHEMBL4576703	23-29	NLR family, pyrin domain containing 3	Mus musculus	168-173
35546047-7	2022	Cyn treatment reduced hind paw swelling and M1 macrophage infiltration, suppressed the mRNA expression of inflammatory factors, and inhibited NLRP3 inflammasome activation in vivo, in addition to inhibiting the phosphorylation of IKKa/beta, p65, and c-Jun NH 2-terminal kinase (JNK).	cynarine	0-3	NLR family, pyrin domain containing 3	Mus musculus	142-147
35546047-8	2022	Furthermore, Cyn exerted anti-inflammatory and anti-swelling effects in mice with GA by regulating the NF-kappaB and JNK pathways and NLRP3 inflammasomes.	cynarine	13-16	NLR family, pyrin domain containing 3	Mus musculus	134-139
35603196-0	2022	Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome.	tripeptide K-26	11-21	NLR family, pyrin domain containing 3	Mus musculus	110-115
35566338-0	2022	ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-kappaB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation.	ST2825	0-6	NLR family, pyrin domain containing 3	Mus musculus	89-94
35566338-0	2022	ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-kappaB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation.	ros	85-88	NLR family, pyrin domain containing 3	Mus musculus	89-94
35508474-11	2022	Then, WWP1 or YTHDF1 overexpression diminished LDH activity, NLRP3 inflammasomes and caspase-1-mediated cleavage of GSDMD in LPS + ATP-induced RAW264.7 cells.	Adenosine Triphosphate	131-134	NLR family, pyrin domain containing 3	Mus musculus	61-66
35099110-0	2022	2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide.	2,4-Dichlorophenoxyacetic Acid	0-30	NLR family, pyrin domain containing 3	Mus musculus	57-62
35099110-0	2022	2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide.	ros	39-42	NLR family, pyrin domain containing 3	Mus musculus	57-62
35344845-0	2022	PM2.5 induced lung injury through upregulating ROS-dependent NLRP3 Inflammasome-Mediated Pyroptosis.	Reactive Oxygen Species	47-50	NLR family, pyrin domain containing 3	Mus musculus	61-66
35344845-10	2022	This study describes a potentially important mechanism of PM2.5-induced lung damage that PM2.5 promotes lung injury via upregulating ROS-NLRP3-mediated the RAW264.7 cells pyroptosis.	Reactive Oxygen Species	133-136	NLR family, pyrin domain containing 3	Mus musculus	137-142
35417750-6	2022	In the P. bovis group, treatment with N-acetyl-l-cysteine (NAC) significantly decreased protein expression in NF-kappaB and the NLRP3 inflammasome pathway, as well as IL-1beta, IL-6 and IL-18, whereas protein expression in the Nrf2 pathway was significantly changed.	Acetylcysteine	59-62	NLR family, pyrin domain containing 3	Mus musculus	128-133
35417750-9	2022	In conclusion, P. bovis induced an inflammatory response via the NF-kappaB/NLRP3 inflammasome pathway; however, scavenging ROS or activating Nrf2 mitigated the inflammatory response in infected mMECs.	ros	123-126	NLR family, pyrin domain containing 3	Mus musculus	75-80
35583915-0	2022	Nano-chemically Modified Tetracycline-3 (nCMT-3) Attenuates Acute Lung Injury via Blocking sTREM-1 Release and NLRP3 Inflammasome Activation.	Tetracycline	25-37	NLR family, pyrin domain containing 3	Mus musculus	111-116
35203043-8	2022	MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-kappaB), NLRP3 inflammasome and proinflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and MCP-1.	Ethanol	26-33	NLR family, pyrin domain containing 3	Mus musculus	165-170
35285100-0	2022	Leonurine inhibits the TXNIP/NLRP3 and NF-kappaB pathways via Nrf2 activation to alleviate carrageenan-induced pleurisy in mice.	leonurine	0-9	NLR family, pyrin domain containing 3	Mus musculus	29-34
35285100-8	2022	These results indicate that Leo confers potent protection against CAR-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappaB pathways dependent on Nrf2, which may serve as a promising agent for attenuating pleurisy.	leonurine	28-31	NLR family, pyrin domain containing 3	Mus musculus	111-116
35285100-8	2022	These results indicate that Leo confers potent protection against CAR-induced pleurisy by inhibiting the TXNIP/NLRP3 and NF-kappaB pathways dependent on Nrf2, which may serve as a promising agent for attenuating pleurisy.	Carrageenan	66-69	NLR family, pyrin domain containing 3	Mus musculus	111-116
35485077-6	2022	We found that 6-Shogaol suppressed CCl4-induced inflammatory response by inhibiting macrophage recruitment, release of pro-inflammatory factors, and activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome in liver tissues.	shogaol	14-23	NLR family, pyrin domain containing 3	Mus musculus	219-224
35203043-8	2022	MSM treatment reduced the ethanol-induced inflammatory factors including myeloperoxidase (MPO), iNOS/NO, cyclooxygenase (COX)-2, nuclear factor kappa B (NF-kappaB), NLRP3 inflammasome and proinflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and MCP-1.	dimethyl sulfone	0-3	NLR family, pyrin domain containing 3	Mus musculus	165-170
35248848-0	2022	Hydroxytyrosol alleviates dextran sodium sulfate-induced colitis by inhibiting NLRP3 inflammasome activation and modulating gut microbiota in vivo.	3,4-dihydroxyphenylethanol	0-14	NLR family, pyrin domain containing 3	Mus musculus	79-84
35248848-0	2022	Hydroxytyrosol alleviates dextran sodium sulfate-induced colitis by inhibiting NLRP3 inflammasome activation and modulating gut microbiota in vivo.	dextran sodium sulfate	26-48	NLR family, pyrin domain containing 3	Mus musculus	79-84
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	NLR family, pyrin domain containing 3	Mus musculus	35-40
35189551-5	2022	Notably, a higher inducibility of NLRP3 inflammasome activation in response to ATP and nigericin following challenge with lipopolysaccharide (LPS) was observed in BACH1-deficient macrophages compared to wild-type cells.	Adenosine Triphosphate	79-82	NLR family, pyrin domain containing 3	Mus musculus	34-39
35189551-5	2022	Notably, a higher inducibility of NLRP3 inflammasome activation in response to ATP and nigericin following challenge with lipopolysaccharide (LPS) was observed in BACH1-deficient macrophages compared to wild-type cells.	Nigericin	87-96	NLR family, pyrin domain containing 3	Mus musculus	34-39
35240537-6	2022	Importantly, we found that Mul markedly increased liver TRIM31 expression in CCl4-treated mice, accompanied with the inactivation of NOD-like receptor protein 3 (NLRP3) inflammasome.	Carbon Tetrachloride	77-81	NLR family, pyrin domain containing 3	Mus musculus	133-160
35240537-6	2022	Importantly, we found that Mul markedly increased liver TRIM31 expression in CCl4-treated mice, accompanied with the inactivation of NOD-like receptor protein 3 (NLRP3) inflammasome.	Carbon Tetrachloride	77-81	NLR family, pyrin domain containing 3	Mus musculus	162-167
35531699-0	2022	(Butyl alcohol extract of Baitouweng Decoction alleviates vulvovaginal candidiasis in mice by downregulating NLRP3 inflammasome and related signal pathways).	1-Butanol	1-14	NLR family, pyrin domain containing 3	Mus musculus	109-114
35531699-1	2022	This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome.	1-Butanol	41-54	NLR family, pyrin domain containing 3	Mus musculus	237-242
35403430-0	2022	Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout.	n-sulfonylureas	48-63	NLR family, pyrin domain containing 3	Mus musculus	67-72
35571141-0	2022	Suppression of NLRP3 Inflammasome by Dihydroarteannuin via the HIF-1alpha and JAK3/STAT3 Signaling Pathway Contributes to Attenuation of Collagen-Induced Arthritis in Mice.	dihydroarteannuin	37-54	NLR family, pyrin domain containing 3	Mus musculus	15-20
35403430-3	2022	Novel N-sulfonylureas were obtained by the replacement of the hexahydroindacene moiety of the previously described NLRP3 inhibitor MCC950.	n-sulfonylureas	6-21	NLR family, pyrin domain containing 3	Mus musculus	115-120
35403430-3	2022	Novel N-sulfonylureas were obtained by the replacement of the hexahydroindacene moiety of the previously described NLRP3 inhibitor MCC950.	hexahydroindacene	62-79	NLR family, pyrin domain containing 3	Mus musculus	115-120
35571141-7	2022	Therefore, we concluded that DHA efficiently alleviated the inflammation and arthritic symptoms in CIA mice and downregulated inflammation in part by inhibiting NLRP3 expression via the HIF-1alpha and JAK3/STAT3 signaling pathway.	dihydroarteannuin	29-32	NLR family, pyrin domain containing 3	Mus musculus	161-166
35502244-7	2022	Results: Dex treatment significantly reduced pro-inflammatory M1 macrophage polarization and NLRP3 inflammasome activation in the lungs relative to the mice treated with LPS.	Dexmedetomidine	9-12	NLR family, pyrin domain containing 3	Mus musculus	93-98
35473680-0	2022	Sevoflurane anesthesia ameliorates LPS-induced acute lung injury (ALI) by modulating a novel LncRNA LINC00839/miR-223/NLRP3 axis.	Sevoflurane	0-11	NLR family, pyrin domain containing 3	Mus musculus	118-123
35473680-8	2022	MiR-223 inhibitor reversed the inhibitory effects of LINC00839 knockdown on NLRP3-mediated pyroptosis in LPS-treated MPVECs.	linc00839	53-62	NLR family, pyrin domain containing 3	Mus musculus	76-81
35473680-9	2022	Furthermore, both miR-223 ablation and NLRP3 overexpression abrogated the protective effects of sevoflurane on LPS-treated MPVECs.	Sevoflurane	96-107	NLR family, pyrin domain containing 3	Mus musculus	39-44
35473680-10	2022	CONCLUSION: In general, our work illustrates that sevoflurane regulates the LINC00839/miR-223/NLRP3 axis to ameliorate LPS-induced ALI, which might provide a novel promising candidate for the prevention of ALI.	Sevoflurane	50-61	NLR family, pyrin domain containing 3	Mus musculus	94-99
35502244-8	2022	The similar pattern reduction of NLRP3 inflammasome activation by Dex was also found in A549 cells.	Dexmedetomidine	66-69	NLR family, pyrin domain containing 3	Mus musculus	33-38
35502244-13	2022	Conclusion: Dex protected against LPS-induced lung injury and suppressed LPS-induced pulmonary inflammatory responses by attenuating the NLRP3 inflammasome activation and promoting anti-inflammatory M2 macrophage polarization.	Dexmedetomidine	12-15	NLR family, pyrin domain containing 3	Mus musculus	137-142
35528515-7	2022	Mechanistically, the expressions of p-AKT, p-mTOR, p-P65, NLRP3, and cleaved-caspase-1 were decreased after MgH2 treatment, indicating that AKT/mTOR and NF-kappaB/NLRP3/IL-1beta pathways participated in the protective effects of MgH2.	magnesium;hydride	108-112	NLR family, pyrin domain containing 3	Mus musculus	163-168
35528515-7	2022	Mechanistically, the expressions of p-AKT, p-mTOR, p-P65, NLRP3, and cleaved-caspase-1 were decreased after MgH2 treatment, indicating that AKT/mTOR and NF-kappaB/NLRP3/IL-1beta pathways participated in the protective effects of MgH2.	magnesium;hydride	108-112	NLR family, pyrin domain containing 3	Mus musculus	58-63
35528515-9	2022	All these findings demonstrated that MgH2 could exert an ARDS-protective effect by regulating the AKT/mTOR and NF-kappaB/NLRP3/IL-1beta pathways to suppress LPS-induced inflammatory reaction, oxidative stress injury, apoptosis, and barrier breakdown, which may provide a potential strategy for the prevention and treatment of ARDS.	magnesium;hydride	37-41	NLR family, pyrin domain containing 3	Mus musculus	121-126
35483236-0	2022	Paeoniflorin ameliorates diabetic liver injury by targeting the TXNIP-mediated NLRP3 inflammasome in db/db mice.	peoniflorin	0-12	NLR family, pyrin domain containing 3	Mus musculus	79-84
35483427-8	2022	Along with the activation of proinflammatory biomarkers (NF-kappaB, STAT3, NLRP3 inflammasome), lung tissue homogenates from mice on an alcohol diet showed overexpression of ACE2 compared with mice on a control diet.	Alcohols	136-143	NLR family, pyrin domain containing 3	Mus musculus	75-80
35483236-12	2022	CONCLUSION: Using a combination of animal and in vitro experiments, this study demonstrated for the first time that PF ameliorates DLI through targeting the TXNIP-activated NLRP3 inflammasome.	peoniflorin	116-118	NLR family, pyrin domain containing 3	Mus musculus	173-178
35468366-0	2022	Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	79-84
35468366-8	2022	Overall, the current study suggests that melatonin exerts protective roles on LPS-induced ALI and pyroptosis by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis.	Melatonin	41-50	NLR family, pyrin domain containing 3	Mus musculus	123-128
35468366-7	2022	Furthermore, melatonin inhibited LPS-induced pyroptosis by reversing the overexpression of NLRP3, Caspase-1, IL-1beta, IL-18 and GSDMD-N, as well as LDH release and TUNEL-positive cells in A549 cells and Raw264.7 cells.	Melatonin	13-22	NLR family, pyrin domain containing 3	Mus musculus	91-96
35565726-4	2022	Here, we reported that nicotine promoted hepatocyte pyroptosis, as evidenced by the elevation of propidium iodide (PI)-positive cells, the activation of Caspase-1 and gasdermin D (GSDMD), the enhanced expression of NOD-like receptor containing pyrin domain 3 (NLRP3) and the increased release of lactate dehydrogenase (LDH), interleukin (IL)-1beta and IL-18.	Nicotine	23-31	NLR family, pyrin domain containing 3	Mus musculus	215-258
35565726-4	2022	Here, we reported that nicotine promoted hepatocyte pyroptosis, as evidenced by the elevation of propidium iodide (PI)-positive cells, the activation of Caspase-1 and gasdermin D (GSDMD), the enhanced expression of NOD-like receptor containing pyrin domain 3 (NLRP3) and the increased release of lactate dehydrogenase (LDH), interleukin (IL)-1beta and IL-18.	Nicotine	23-31	NLR family, pyrin domain containing 3	Mus musculus	260-265
35445640-0	2022	Ferulic acid produces neuroprotection against radiation-induced neuroinflammation by affecting NLRP3 inflammasome activation.	ferulic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	95-100
35448938-7	2022	In a 5-FU-induced chemoentermuctis mouse model, Lactobacillus rhamnoides can increase the concentrations of three SCFAs in faeces and increase the concentrations of IL-1beta, IL-6 and IgA in serum, and decrease the expressions of NLRP3 and IL-17 in spleen cells.	rhamnoides	62-72	NLR family, pyrin domain containing 3	Mus musculus	230-235
35545588-0	2022	(The role of ROS/TXNIP/NLRP3 pathway in the skin injury of trichloroethylene sensitized mice).	Trichloroethylene	59-76	NLR family, pyrin domain containing 3	Mus musculus	23-28
35545588-1	2022	Objective: To explore the mechanism of reactive oxygen species/thioredoxin-interacting protein/nucleotide-binding oligomerization domain-like receptor 3 (ROS/TXNIP/NLRP3) pathway in the skin injury of trichloroethylene (TCE) sensitized mice.	Reactive Oxygen Species	39-62	NLR family, pyrin domain containing 3	Mus musculus	164-169
35545588-1	2022	Objective: To explore the mechanism of reactive oxygen species/thioredoxin-interacting protein/nucleotide-binding oligomerization domain-like receptor 3 (ROS/TXNIP/NLRP3) pathway in the skin injury of trichloroethylene (TCE) sensitized mice.	Trichloroethylene	201-218	NLR family, pyrin domain containing 3	Mus musculus	164-169
35545588-1	2022	Objective: To explore the mechanism of reactive oxygen species/thioredoxin-interacting protein/nucleotide-binding oligomerization domain-like receptor 3 (ROS/TXNIP/NLRP3) pathway in the skin injury of trichloroethylene (TCE) sensitized mice.	Trichloroethylene	220-223	NLR family, pyrin domain containing 3	Mus musculus	164-169
35498131-0	2022	Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.	Polysaccharides	0-15	NLR family, pyrin domain containing 3	Mus musculus	128-133
35498131-11	2022	N-Acetyl-L-cysteine (NAC) administration also inhibited oxidative stress and activation of the calpain system and the NLRP3 inflammasome.	Acetylcysteine	0-19	NLR family, pyrin domain containing 3	Mus musculus	118-123
35498131-11	2022	N-Acetyl-L-cysteine (NAC) administration also inhibited oxidative stress and activation of the calpain system and the NLRP3 inflammasome.	Acetylcysteine	21-24	NLR family, pyrin domain containing 3	Mus musculus	118-123
35498131-13	2022	We also showed that PSP prevented CUMS-induced changes in the calpain system and the Nrf2 and NLRP3 signaling pathways and reduced depression-like behavior.	cums	34-38	NLR family, pyrin domain containing 3	Mus musculus	94-99
35545588-11	2022	Compared with the solvent control group and corresponding sensitized negative groups, the expression levels of NLRP3, ASC, Caspase 1, IL-1beta, TXNIP proteins and the content of ROS in the TCE sensitized positive group and TCE+Mito TEMPO sensitized positive group were significantly increased (P<0.05) .	Trichloroethylene	189-192	NLR family, pyrin domain containing 3	Mus musculus	111-116
35545588-12	2022	Compared with TCE sensitized positive group, the expression levels of NLRP3, ASC, Caspase 1, IL-1beta, TXNIP proteins and the content of ROS in the TCE+Mito TEMPO sensitized positive group were significantly decreased (P<0.05) .	Trichloroethylene	14-17	NLR family, pyrin domain containing 3	Mus musculus	70-75
35545588-12	2022	Compared with TCE sensitized positive group, the expression levels of NLRP3, ASC, Caspase 1, IL-1beta, TXNIP proteins and the content of ROS in the TCE+Mito TEMPO sensitized positive group were significantly decreased (P<0.05) .	Trichloroethylene	148-151	NLR family, pyrin domain containing 3	Mus musculus	70-75
35545588-13	2022	Conclusion: ROS/TXNIP/NLRP3 pathway was activated and then encouraged the release of IL-1beta, finally aggravated the TCE-induced skin injury.	Trichloroethylene	118-121	NLR family, pyrin domain containing 3	Mus musculus	22-27
35182973-0	2022	Paeonol protects against acute pancreatitis by inhibiting M1 macrophage polarization via the NLRP3 inflammasomes pathway.	paeonol	0-7	NLR family, pyrin domain containing 3	Mus musculus	93-98
35182973-7	2022	In addition, specific NLRP3 inhibitor MCC950 eliminated the protective effect of Pae on AP induced by caerulein in mice.	Ceruletide	102-111	NLR family, pyrin domain containing 3	Mus musculus	22-27
35530283-0	2022	The small molecule NLRP3 inhibitor RRx-001 potentiates regorafenib activity and attenuates regorafenib-induced toxicity in mice bearing human colorectal cancer xenografts.	RRx-001	35-42	NLR family, pyrin domain containing 3	Mus musculus	19-24
35530283-0	2022	The small molecule NLRP3 inhibitor RRx-001 potentiates regorafenib activity and attenuates regorafenib-induced toxicity in mice bearing human colorectal cancer xenografts.	regorafenib	55-66	NLR family, pyrin domain containing 3	Mus musculus	19-24
35429817-8	2022	In the cellular experiments, PM2.5 (160 mug/ml) evoked mRTECs inflammation and apoptosis through the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) /IL-1beta axis, while paricalcitol (120 mug/ml) reversed these processes.	paricalcitol	180-192	NLR family, pyrin domain containing 3	Mus musculus	151-156
35414518-8	2022	In MRL/lpr and NZM2328 mice, inhibition of NLRP3 activation suppressed NLRP3 activated Tfh cell expansion as well as attenuated lupus-like phenotypes.	nzm2328	15-22	NLR family, pyrin domain containing 3	Mus musculus	43-48
35496300-16	2022	PTS decreased the levels of NLRP3 and IL-1beta mRNA and the expressions of their proteins in DOX-treated mice.	Doxorubicin	93-96	NLR family, pyrin domain containing 3	Mus musculus	28-33
35464766-1	2022	Purpose: Activation of NLR (nucleotide-binding and leucine-rich repeat immune receptor) family pyrin domain containing 3 (NLRP3) inflammasome mediating interleukin- (IL-) 1beta secretion has emerged as an important component of inflammatory processes in atherogenesis.	Leucine	51-58	NLR family, pyrin domain containing 3	Mus musculus	122-127
35464766-7	2022	In vitro studies demonstrated that oxidized low-density lipoprotein cholesterol (ox-LDL) increased the release of lactate dehydrogenase (LDH) and upregulated the expressions of cleaved caspase-1, cleaved IL-1beta and gasdermin D (GSMD) in WT peritoneal macrophages (PMs) in a NLRP3-dependent manner.	Cholesterol	68-79	NLR family, pyrin domain containing 3	Mus musculus	276-281
35496300-0	2022	Thioredoxin-1 Activation by Pterostilbene Protects Against Doxorubicin-Induced Hepatotoxicity via Inhibiting the NLRP3 Inflammasome.	pterostilbene	28-41	NLR family, pyrin domain containing 3	Mus musculus	113-118
35496300-0	2022	Thioredoxin-1 Activation by Pterostilbene Protects Against Doxorubicin-Induced Hepatotoxicity via Inhibiting the NLRP3 Inflammasome.	Doxorubicin	59-70	NLR family, pyrin domain containing 3	Mus musculus	113-118
35414518-8	2022	In MRL/lpr and NZM2328 mice, inhibition of NLRP3 activation suppressed NLRP3 activated Tfh cell expansion as well as attenuated lupus-like phenotypes.	nzm2328	15-22	NLR family, pyrin domain containing 3	Mus musculus	71-76
35495917-12	2022	The effects of Fru may be associated with activation of the NF-kappaB-NLRP3 pathway.	Fructose	15-18	NLR family, pyrin domain containing 3	Mus musculus	70-75
35495917-0	2022	Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway.	Fructose	0-8	NLR family, pyrin domain containing 3	Mus musculus	85-90
35410316-2	2022	The P2X7/NLRP3 pathway plays an essential role in amplifying inflammation via an ATP feedback loop, promoting the inflammatory response, pyroptosis, and apoptosis of RECs in the early stages of diabetic retinopathy induced by hyperglycemia and inflammation.	Adenosine Triphosphate	81-84	NLR family, pyrin domain containing 3	Mus musculus	9-14
35101458-0	2022	Dihydromyricetin improves LPS-induced sickness and depressive-like behaviors in mice by inhibiting the TLR4/Akt/HIF1a/NLRP3 pathway.	dihydromyricetin	0-16	NLR family, pyrin domain containing 3	Mus musculus	118-123
35410316-5	2022	The expression of inflammasome-related proteins P2X7 and NLRP3, and apoptosis in the retinas of 3TC-treated diabetic mice were compared to those of untreated diabetic mice.	Lamivudine	96-99	NLR family, pyrin domain containing 3	Mus musculus	57-62
35458684-0	2022	Eriodictyol and Homoeriodictyol Improve Memory Impairment in Abeta25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome.	eriodictyol	0-11	NLR family, pyrin domain containing 3	Mus musculus	103-108
35458684-0	2022	Eriodictyol and Homoeriodictyol Improve Memory Impairment in Abeta25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome.	homoeriodictyol	16-31	NLR family, pyrin domain containing 3	Mus musculus	103-108
35458684-8	2022	The effect of nigericin (an agonist of the NLRP3 inflammasome) on Eri and Hom intervention in LPS-induced N9 microglia was examined using a High Content Screening System.	Nigericin	14-23	NLR family, pyrin domain containing 3	Mus musculus	43-48
35458684-11	2022	Furthermore, the effect of Eri and Hom on LPS-induced N9 microglia disappeared after the addition of nigericin to agonize NLRP3 receptors.	Nigericin	101-110	NLR family, pyrin domain containing 3	Mus musculus	122-127
35101458-10	2022	Interestingly, DMY dramatically inhibited the expression of TLR4/Akt/HIF1a/NLRP3 signaling pathway-related proteins both in Vitro and in Vivo, including TLR4, CD14, PDPk1, p-Akt, p-NF-kappaB p65, p-GSK-3beta, HIF1a, NLRP3, ASC, and caspase-1.	dihydromyricetin	15-18	NLR family, pyrin domain containing 3	Mus musculus	75-80
35101458-10	2022	Interestingly, DMY dramatically inhibited the expression of TLR4/Akt/HIF1a/NLRP3 signaling pathway-related proteins both in Vitro and in Vivo, including TLR4, CD14, PDPk1, p-Akt, p-NF-kappaB p65, p-GSK-3beta, HIF1a, NLRP3, ASC, and caspase-1.	dihydromyricetin	15-18	NLR family, pyrin domain containing 3	Mus musculus	216-221
35101458-11	2022	The above results suggested that DMY suppressed the activation of the TLR4/Akt/HIF1a/NLRP3 pathway, which may contribute to its anti-depressive effects.	dihydromyricetin	33-36	NLR family, pyrin domain containing 3	Mus musculus	85-90
35464414-10	2022	To sum up, macrophage pyroptosis is an upstream event of silica-induced pulmonary inflammation promoted by ROS through the TLR4/NLRP3/NF-kappaB signaling axis.	Silicon Dioxide	57-63	NLR family, pyrin domain containing 3	Mus musculus	128-133
35464414-10	2022	To sum up, macrophage pyroptosis is an upstream event of silica-induced pulmonary inflammation promoted by ROS through the TLR4/NLRP3/NF-kappaB signaling axis.	ros	107-110	NLR family, pyrin domain containing 3	Mus musculus	128-133
35464414-4	2022	Also, silica-exposed macrophages generated higher levels of ROS, together with the upregulated expression of NLRP3, ASC, Caspase-1, GSDMD, IL-1beta, and IL-6.	Silicon Dioxide	6-12	NLR family, pyrin domain containing 3	Mus musculus	109-114
35463001-12	2022	Furthermore, the potassium (K+) channel inhibitor glyburide decreased LDH release and suppressed NLRP3 inflammasome activation and pyroptosis in HCECs exposed to HKCA.	Glyburide	50-59	NLR family, pyrin domain containing 3	Mus musculus	97-102
35527434-1	2022	Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD.	CY5.5 cyanine dye	176-181	NLR family, pyrin domain containing 3	Mus musculus	47-52
35527434-1	2022	Objective: To explore the relationship between NLRP3-mediated pyroptosis and olfactory dysfunction (OD) in allergic rhinitis (AR), and to evaluate the therapeutic potential of CY-09, a selective NLRP3 inhibitor for OD.	CY5.5 cyanine dye	176-181	NLR family, pyrin domain containing 3	Mus musculus	195-200
35463001-12	2022	Furthermore, the potassium (K+) channel inhibitor glyburide decreased LDH release and suppressed NLRP3 inflammasome activation and pyroptosis in HCECs exposed to HKCA.	hkca	162-166	NLR family, pyrin domain containing 3	Mus musculus	97-102
35527434-11	2022	CY-09 could significantly reduce the level of NLRP3, caspase-1, GSDMD, IL-1beta and IL-18 expression, and inhibite the activation of microglia and astrocytes in the olfactory bulb tissues (all P<0.05).	CY5.5 cyanine dye	0-5	NLR family, pyrin domain containing 3	Mus musculus	46-51
35527434-13	2022	CY-09 could improve the olfactory function in AR mice, which may be related to blocking the NLRP3-mediated pyroptosis.	CY5.5 cyanine dye	0-5	NLR family, pyrin domain containing 3	Mus musculus	92-97
35368226-0	2022	Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes.	Uric Acid	23-39	NLR family, pyrin domain containing 3	Mus musculus	62-67
35464490-1	2022	Amyloid beta (Abeta) and/or ATP activate the NLRP3 inflammasome (N3I) via P2X7R in microglia, which is crucial in neuroinflammation in Alzheimer"s disease (AD).	Adenosine Triphosphate	28-31	NLR family, pyrin domain containing 3	Mus musculus	45-50
35379787-21	2022	If not effectively compensated, it compromises autophagic flux, leads to dysfunctional mitochondria accumulation, further produces ROS to activate NLRP3, eventually accelerates heart failure.	Reactive Oxygen Species	131-134	NLR family, pyrin domain containing 3	Mus musculus	147-152
35368226-3	2022	We investigated the role of the K+ channel Kv1.5 in monosodium urate crystal (MSU)-induced activation of the NLRP3 inflammasome and electrical remodeling in mouse and human macrophages J774.1 and THP-1, and mouse atrial myocytes HL-1.	monosodium urate crystal	52-76	NLR family, pyrin domain containing 3	Mus musculus	109-114
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	NLR family, pyrin domain containing 3	Mus musculus	55-60
35368226-3	2022	We investigated the role of the K+ channel Kv1.5 in monosodium urate crystal (MSU)-induced activation of the NLRP3 inflammasome and electrical remodeling in mouse and human macrophages J774.1 and THP-1, and mouse atrial myocytes HL-1.	msu	78-81	NLR family, pyrin domain containing 3	Mus musculus	109-114
35373915-10	2022	CONCLUSION: 10-HDA alleviates DSS-induced colitis by regulating the NLRP3 inflammasome-mediated pyroptotic pathway and enhancing colonic barrier function.	dss	30-33	NLR family, pyrin domain containing 3	Mus musculus	68-73
35368226-7	2022	MSU induced caspase-1 expression in LPS-primed J774.1 cells and IL-1beta secretion, suggesting NLRP3 inflammasome activation.	msu	0-3	NLR family, pyrin domain containing 3	Mus musculus	95-100
35368226-14	2022	CONCLUSIONS: Kv1.5 regulates MSU-induced activation of NLRP3 inflammasome in macrophages.	msu	29-32	NLR family, pyrin domain containing 3	Mus musculus	55-60
35190353-0	2022	The Chinese herbal medicine Fufang Zhenzhu Tiaozhi protects against diabetic cardiomyopathy by alleviating cardiac lipotoxicity-induced oxidative stress and NLRP3-dependent inflammasome activation.	fufang zhenzhu tiaozhi	28-50	NLR family, pyrin domain containing 3	Mus musculus	157-162
35419168-0	2022	Isoflurane Attenuates Cerebral Ischaemia-Reperfusion Injury via the TLR4-NLRP3 Signalling Pathway in Diabetic Mice.	Isoflurane	0-10	NLR family, pyrin domain containing 3	Mus musculus	73-78
35419168-11	2022	Then, we found that ISO decreased TLR4-NLRP3 inflammasome activation in microglia and the excessive autophagy induced by CIRI in diabetic mice.	Isoflurane	20-23	NLR family, pyrin domain containing 3	Mus musculus	39-44
35419168-13	2022	In summary, our study indicated that ISO exerts neuroprotective effects against the neuroinflammation and autophagy observed during diabetic stroke via the TLR4-NLRP3 signalling pathway.	Isoflurane	37-40	NLR family, pyrin domain containing 3	Mus musculus	161-166
35148014-2	2022	Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome was identified as a key mediator of inflammation, and excessive activation of the NLRP3 inflammasome was shown to contribute to the pathogenesis of a wide variety of diseases.	Leucine	57-64	NLR family, pyrin domain containing 3	Mus musculus	110-115
35148014-2	2022	Recently, the nucleotide-binding oligomerization domain, leucine-rich repeat-, and pyrin domain-containing 3 (NLRP3) inflammasome was identified as a key mediator of inflammation, and excessive activation of the NLRP3 inflammasome was shown to contribute to the pathogenesis of a wide variety of diseases.	Leucine	57-64	NLR family, pyrin domain containing 3	Mus musculus	212-217
35143076-6	2022	PBzyme inhibits the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)/ATP-induced activation of microglial NLRP3 inflammasomes, attenuates the damage of mitochondrial membrane potential, and rescues dopaminergic neurons.	pbzyme	0-6	NLR family, pyrin domain containing 3	Mus musculus	112-117
35143076-6	2022	PBzyme inhibits the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)/ATP-induced activation of microglial NLRP3 inflammasomes, attenuates the damage of mitochondrial membrane potential, and rescues dopaminergic neurons.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	20-67	NLR family, pyrin domain containing 3	Mus musculus	112-117
35143076-6	2022	PBzyme inhibits the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)/ATP-induced activation of microglial NLRP3 inflammasomes, attenuates the damage of mitochondrial membrane potential, and rescues dopaminergic neurons.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	69-73	NLR family, pyrin domain containing 3	Mus musculus	112-117
35143076-6	2022	PBzyme inhibits the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)/ATP-induced activation of microglial NLRP3 inflammasomes, attenuates the damage of mitochondrial membrane potential, and rescues dopaminergic neurons.	Adenosine Triphosphate	75-78	NLR family, pyrin domain containing 3	Mus musculus	112-117
35143076-8	2022	Both in vitro and in vivo results demonstrate that PBzyme reduces the activation of microglial NLRP3 inflammasomes and caspase-1 by scavenging reactive oxygen species, thereby downregulating GSDMD cleavage as well as inflammatory factor production, and eventually leading to the inhibition of microglia pyroptosis.	Oxygen	152-158	NLR family, pyrin domain containing 3	Mus musculus	95-100
35190353-8	2022	RESULTS: Our study indicated that FTZ improved cardiac function, attenuated heart hypertrophy, improved serum lipid and proinflammatory cytokine levels, and restrained oxidative stress and NLRP3 inflammasome-induced inflammatory activities in diabetic mouse hearts.	CHEMBL1354522	34-37	NLR family, pyrin domain containing 3	Mus musculus	189-194
35190353-9	2022	The in vitro data suggested that FTZ suppressed intercellular lipid accumulation as well as palmitic acid (PA)-induced oxidative stress and NLRP3 inflammasome-dependent pyroptosis in cardiomyocytes.	CHEMBL1354522	33-36	NLR family, pyrin domain containing 3	Mus musculus	140-145
35190353-9	2022	The in vitro data suggested that FTZ suppressed intercellular lipid accumulation as well as palmitic acid (PA)-induced oxidative stress and NLRP3 inflammasome-dependent pyroptosis in cardiomyocytes.	Palmitic Acid	92-105	NLR family, pyrin domain containing 3	Mus musculus	140-145
35190353-9	2022	The in vitro data suggested that FTZ suppressed intercellular lipid accumulation as well as palmitic acid (PA)-induced oxidative stress and NLRP3 inflammasome-dependent pyroptosis in cardiomyocytes.	Palmitic Acid	107-109	NLR family, pyrin domain containing 3	Mus musculus	140-145
35190353-10	2022	CONCLUSION: Our present findings indicate that FTZ inhibits DCM by inhibiting both oxidative stress and NLRP3 inflammasome activation induced by cardiac lipotoxicity.	CHEMBL1354522	47-50	NLR family, pyrin domain containing 3	Mus musculus	104-109
35340872-0	2022	Rosiglitazone ameliorates acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome.	Rosiglitazone	0-13	NLR family, pyrin domain containing 3	Mus musculus	122-127
34984798-0	2022	Lithium intoxication induced pyroptosis via ROS/NF-kappaB/NLRP3 inflammasome regulatory networks in kidney of mice.	Lithium	0-7	NLR family, pyrin domain containing 3	Mus musculus	58-63
34984798-8	2022	In the vitro study, ROS as an upstream signal phosphorylated IkappaBalpha and NF-kappaB, up-regulated the NLRP3 inflammasome, increased caspase3, 6, 7, and 9 to exaggerate inflammation response, finally inducing pyroptosis in renal cells.	Reactive Oxygen Species	20-23	NLR family, pyrin domain containing 3	Mus musculus	106-111
35340872-10	2022	Additionally, treatment with RSG promoted the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, upregulated peroxisome proliferator-activated receptor gamma and inhibited activation of the inflammasome NOD-like receptor protein 3 (NLRP3).	Rosiglitazone	29-32	NLR family, pyrin domain containing 3	Mus musculus	240-267
35063750-0	2022	Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.	andrographolide	0-18	NLR family, pyrin domain containing 3	Mus musculus	28-33
35340872-10	2022	Additionally, treatment with RSG promoted the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, upregulated peroxisome proliferator-activated receptor gamma and inhibited activation of the inflammasome NOD-like receptor protein 3 (NLRP3).	Rosiglitazone	29-32	NLR family, pyrin domain containing 3	Mus musculus	269-274
35340872-11	2022	In conclusion, the current study demonstrated that RSG could ameliorate acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome.	Rosiglitazone	51-54	NLR family, pyrin domain containing 3	Mus musculus	168-173
35431795-2	2022	It has been suggested that the NLRP3 inflammasome may be responsible for the neurotoxicity caused by METH.	Methamphetamine	101-105	NLR family, pyrin domain containing 3	Mus musculus	31-36
35431795-3	2022	However, the role of NLRP3 in METH-induced cerebellar Purkinje cell (PC) degeneration and the underlying mechanism remain elusive.	Methamphetamine	30-34	NLR family, pyrin domain containing 3	Mus musculus	21-26
35431795-5	2022	In METH mice models, increased NLRP3 expression, PC degeneration, myelin sheath destruction, axon degeneration, glial cell activation, and motor coordination impairment were observed.	Methamphetamine	3-7	NLR family, pyrin domain containing 3	Mus musculus	31-36
35431795-8	2022	Collectively, these findings suggest that mature IL-1beta secretion mediated by NLRP3-ASC-Caspase 1 may be a critical step in METH-induced cerebellar degeneration and highlight the neuroprotective properties of inflammasome inhibition in cerebellar degeneration.	Methamphetamine	126-130	NLR family, pyrin domain containing 3	Mus musculus	80-85
35082376-12	2022	Overall, our findings showed that M2-EV-enveloped miR-378a-3p inhibited HuR expression and HuR translocation to the cytoplasm to destabilize NLRP3 and block activation of the NLRP3/Caspase-1/GSDMD pathways, thereby attenuating cardiomyocyte pyroptosis.	mir-378a-3p	50-61	NLR family, pyrin domain containing 3	Mus musculus	141-146
35082376-12	2022	Overall, our findings showed that M2-EV-enveloped miR-378a-3p inhibited HuR expression and HuR translocation to the cytoplasm to destabilize NLRP3 and block activation of the NLRP3/Caspase-1/GSDMD pathways, thereby attenuating cardiomyocyte pyroptosis.	mir-378a-3p	50-61	NLR family, pyrin domain containing 3	Mus musculus	175-180
35137954-4	2022	Using murine bone marrow-derived macrophages, mixed glia and organotypic hippocampal slice cultures (OHSCs), we demonstrate that DMI, 4OI and DMF pre-treatment inhibit pro-inflammatory cytokine production in response to lipopolysaccharide (LPS), as well as inhibiting subsequent NLRP3 inflammasome activation induced by nigericin.	dimethyl itaconate	129-132	NLR family, pyrin domain containing 3	Mus musculus	279-284
35137954-4	2022	Using murine bone marrow-derived macrophages, mixed glia and organotypic hippocampal slice cultures (OHSCs), we demonstrate that DMI, 4OI and DMF pre-treatment inhibit pro-inflammatory cytokine production in response to lipopolysaccharide (LPS), as well as inhibiting subsequent NLRP3 inflammasome activation induced by nigericin.	Dimethyl Fumarate	142-145	NLR family, pyrin domain containing 3	Mus musculus	279-284
35091339-0	2022	Disulfiram inhibits oxidative stress and NLRP3 inflammasome activation to prevent LPS-induced cardiac injury.	Disulfiram	0-10	NLR family, pyrin domain containing 3	Mus musculus	41-46
35064904-0	2022	Pratensein Mitigates Oxidative Stress and NLRP3 Inflammasome Activation in OGD/R-Injured HT22 Cells by Activating Nrf2-Anti-oxidant Signaling.	4'-methoxy-3',5,7-trihydroxyisoflavone	0-10	NLR family, pyrin domain containing 3	Mus musculus	42-47
35414608-12	2022	In addition, metformin alleviated the necroptosis of HK-2 cells stimulated by LPS and TNF-alpha, evidencing by a decrease in the expression of necroptosis markers p-RIPK1, p-RIPK3 and p-MLKL, and the inflammasome-related markers NLRP3 (NLR family pyrin domain containing 3), ASC (apoptosis-associated speck-like protein containing a CARD), caspase-1.	Metformin	13-22	NLR family, pyrin domain containing 3	Mus musculus	229-234
35414608-12	2022	In addition, metformin alleviated the necroptosis of HK-2 cells stimulated by LPS and TNF-alpha, evidencing by a decrease in the expression of necroptosis markers p-RIPK1, p-RIPK3 and p-MLKL, and the inflammasome-related markers NLRP3 (NLR family pyrin domain containing 3), ASC (apoptosis-associated speck-like protein containing a CARD), caspase-1.	Metformin	13-22	NLR family, pyrin domain containing 3	Mus musculus	236-272
35124564-6	2022	More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models.	mir-139-5p	33-43	NLR family, pyrin domain containing 3	Mus musculus	204-209
35124564-6	2022	More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models.	Reactive Oxygen Species	194-197	NLR family, pyrin domain containing 3	Mus musculus	204-209
35064904-11	2022	This study found that Pra suppresses NLRP3 inflammasome activation through Nrf2 activation, resulting in reduced inflammatory responses and rates of apoptosis in OGD/R-stimulated HT22 cells, highlighting the neuroprotective properties of Pra in CI/R.	4'-methoxy-3',5,7-trihydroxyisoflavone	22-25	NLR family, pyrin domain containing 3	Mus musculus	37-42
35065082-0	2022	Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson"s disease model.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	0-11	NLR family, pyrin domain containing 3	Mus musculus	46-51
35065082-9	2022	Moreover, UA also reduced NLRP3 inflammasome activation both in vitro and in vivo.	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one	10-12	NLR family, pyrin domain containing 3	Mus musculus	26-31
35354793-0	2022	Irisin protects against vascular calcification by activating autophagy and inhibiting NLRP3-mediated vascular smooth muscle cell pyroptosis in chronic kidney disease.	irisin	0-6	NLR family, pyrin domain containing 3	Mus musculus	86-91
35245615-5	2022	The greater expression of NLRP3 and NLRP6, but not AIM2 or P2xR7, in the infarcts of phthalate exposed versus control mice suggests a selectivity in pattern recognition receptor activation.	phthalic acid	85-94	NLR family, pyrin domain containing 3	Mus musculus	26-31
35259481-9	2022	Curbing the NLRP3 inflammasome countered TMAO-induced M1 polarization in bone marrow-derived macrophages.	trimethyloxamine	41-45	NLR family, pyrin domain containing 3	Mus musculus	12-17
35354793-10	2022	Adding the autophagy inhibitor 3-methyladenine or chloroquine attenuated the inhibitory effect of Irisin on beta-GP-induced ROS production, NLRP3 inflammasome activation, pyroptosis, and calcification in VSMCs.	3-methyladenine	31-46	NLR family, pyrin domain containing 3	Mus musculus	140-145
35354793-10	2022	Adding the autophagy inhibitor 3-methyladenine or chloroquine attenuated the inhibitory effect of Irisin on beta-GP-induced ROS production, NLRP3 inflammasome activation, pyroptosis, and calcification in VSMCs.	Chloroquine	50-61	NLR family, pyrin domain containing 3	Mus musculus	140-145
35344105-7	2022	Studies in monocytes indicate that ER stress-induced NLRP3 inflammasome activation occurs by a Ca2+-dependent and ROS-independent mechanism, which is coupled with upregulation of MAMs-resident chaperones, closer ER-mitochondria contacts, as well as mitochondrial depolarization and impaired dynamics.	ros	114-117	NLR family, pyrin domain containing 3	Mus musculus	53-58
35401924-8	2022	And the NLRP3 inflammasome was increased in LPS-activated BV-2 microglia cells in the microglia-neuron coculture system; pretreatment with PK11195 and Midazolam limited this undesirable situation.	Midazolam	151-160	NLR family, pyrin domain containing 3	Mus musculus	8-13
35401924-10	2022	Taken together, TSPO ligands PK11195 and Midazolam showed neuroprotective effects by reducing the inflammatory response of LPS-activated microglia, which may be related to the enhancement of mitophagy and the inhibition of NLRP3 inflammasome.	Midazolam	41-50	NLR family, pyrin domain containing 3	Mus musculus	223-228
35408954-1	2022	Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1beta/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3.	natterin	0-8	NLR family, pyrin domain containing 3	Mus musculus	210-215
35545320-17	2022	CONCLUSIONS: Chlorogenic acid may increase the level of miR-223, target the inhibition of NLRP3 expression, reduce LPS-induced inflammatory response in ALI mice, and alleviate pathological damage of lung tissues.	Chlorogenic Acid	13-29	NLR family, pyrin domain containing 3	Mus musculus	90-95
35332963-18	2022	The TLR2 antagonist Sparstolonin B (SsnB) reduced the expression of TLR2, NLRP3, ASC, Caspase-1, IL-1beta, and IL-37 and the apoptosis in diabetic wounds mice, while the combined intervention of Bacillus subtilis and SsnB reversed the effect of SsnB treatment alone.	sparstolonin B	20-34	NLR family, pyrin domain containing 3	Mus musculus	74-79
35332963-18	2022	The TLR2 antagonist Sparstolonin B (SsnB) reduced the expression of TLR2, NLRP3, ASC, Caspase-1, IL-1beta, and IL-37 and the apoptosis in diabetic wounds mice, while the combined intervention of Bacillus subtilis and SsnB reversed the effect of SsnB treatment alone.	sparstolonin B	36-40	NLR family, pyrin domain containing 3	Mus musculus	74-79
35545320-0	2022	Mechanism of chlorogenic acid reducing lipopolysaccharide-induced acute lung injury in mice by regulating miR-223/NLRP3 axis.	Chlorogenic Acid	13-29	NLR family, pyrin domain containing 3	Mus musculus	114-119
35545320-3	2022	This study aims to investigate whether chlorogenic acid attenuates lipopolysaccharide (LPS)-induced ALI in mice by regulating the microRNA-223 (miR-223)/nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) axis.	Chlorogenic Acid	39-55	NLR family, pyrin domain containing 3	Mus musculus	220-225
35370693-0	2022	Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5"-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	19-55
35408502-3	2022	Here, we discovered that Curcuma phaeocaulis can suppress caspase-1 activation and processing of pro-IL-1beta into mature cytokine in macrophages stimulated with NLRP3 inflammasome activators, such as SiO2 or TiO2 nanoparticles.	Silicon Dioxide	201-205	NLR family, pyrin domain containing 3	Mus musculus	162-167
35408502-6	2022	Interestingly, in contrast to the previously reported higher antioxidant- and NFkappaB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome.	Curcumin	112-120	NLR family, pyrin domain containing 3	Mus musculus	233-238
35408502-6	2022	Interestingly, in contrast to the previously reported higher antioxidant- and NFkappaB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome.	demethoxycurcumin	122-125	NLR family, pyrin domain containing 3	Mus musculus	233-238
35408502-6	2022	Interestingly, in contrast to the previously reported higher antioxidant- and NFkappaB-inhibitory activities of curcumin, DMC exhibited approximately two-fold stronger potency than curcumin against nanoparticle induced activation of NLRP3 inflammasome.	Curcumin	181-189	NLR family, pyrin domain containing 3	Mus musculus	233-238
35401226-0	2022	The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-kappaB/NLRP3-Mediated Pyroptosis.	pilose	25-31	NLR family, pyrin domain containing 3	Mus musculus	103-108
35340691-0	2022	Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome.	Melatonin	0-9	NLR family, pyrin domain containing 3	Mus musculus	92-97
35340691-7	2022	The effect of MEL on the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome was assessed via quantitative real-time PCR and Western blot.	Melatonin	14-17	NLR family, pyrin domain containing 3	Mus musculus	77-82
35370693-0	2022	Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5"-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice.	Adenosine	97-106	NLR family, pyrin domain containing 3	Mus musculus	19-55
35370693-5	2022	The SAH-induced NLRP3-associated inflammatory response and the activation of microglia are also suppressed by metformin.	Metformin	110-119	NLR family, pyrin domain containing 3	Mus musculus	16-21
35370693-7	2022	Collectively, our findings indicate that metformin exerts its neuroprotective effects by inhibiting neuroinflammation in an AMPK-dependent manner, by modulating the production of NLRP3-associated proinflammatory factors and the activation of microglia.	Metformin	41-50	NLR family, pyrin domain containing 3	Mus musculus	179-184
35065059-7	2022	Likewise, naringenin mitigated LPS/D-Gal-triggered inflammation by suppressing NF-kappaB and NLRP3 pathways.	naringenin	10-20	NLR family, pyrin domain containing 3	Mus musculus	93-98
35065059-7	2022	Likewise, naringenin mitigated LPS/D-Gal-triggered inflammation by suppressing NF-kappaB and NLRP3 pathways.	Galactose	35-40	NLR family, pyrin domain containing 3	Mus musculus	93-98
35371034-6	2022	Next, our work showed that PLO can form pores in the cell membrane, leading to the efflux of potassium (K+), NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated caspase-1 activation, and gasdermin D (GSDMD) cleavage.	Potassium	93-102	NLR family, pyrin domain containing 3	Mus musculus	161-166
35151118-0	2022	Targeting NLRP3 signaling by a novel-designed sulfonylurea compound for inhibition of microglial inflammation.	Sulfonylurea Compounds	46-58	NLR family, pyrin domain containing 3	Mus musculus	10-15
35151118-5	2022	AMS-17 inhibited expression of the NLRP3, and its downstream components and cytokines such as caspase-1, tumor necrosis factor-alpha (TNF-alpha), IL-1beta and inducible nitric oxide synthase (iNOS).	Americium	0-3	NLR family, pyrin domain containing 3	Mus musculus	35-40
35292015-0	2022	BuFeiXiaoJiYin ameliorates the NLRP3 inflammation response and gut microbiota in mice with lung cancer companied with Qi-yin deficiency.	bufeixiaojiyin	0-14	NLR family, pyrin domain containing 3	Mus musculus	31-36
35292015-2	2022	METHODS: To investigate the effect of the traditional Chinese medicine BuFeiXiaoJiYin (BFXJY) on NLRP3 inflammasome responses and dysbiosis in lung cancer with Qi-yin deficiency, the female BALB/cA-nu mice were treated with LPS and ATP to induce inflammation, and were intragastrically treated with warm Chinese medicine and smoked with shavings to induce Qi-yin deficiency, as well as were injected with 1 x 107/ml A549 cells to simulate lung cancer.	bufeixiaojiyin	71-85	NLR family, pyrin domain containing 3	Mus musculus	97-102
35292015-2	2022	METHODS: To investigate the effect of the traditional Chinese medicine BuFeiXiaoJiYin (BFXJY) on NLRP3 inflammasome responses and dysbiosis in lung cancer with Qi-yin deficiency, the female BALB/cA-nu mice were treated with LPS and ATP to induce inflammation, and were intragastrically treated with warm Chinese medicine and smoked with shavings to induce Qi-yin deficiency, as well as were injected with 1 x 107/ml A549 cells to simulate lung cancer.	Adenosine Triphosphate	232-235	NLR family, pyrin domain containing 3	Mus musculus	97-102
35292015-7	2022	CONCLUSION: BuFeiXiaoJiYin ameliorates the NLRP3 inflammation response and gut microbiota in mice with lung cancer companied with Qi-yin deficiency.	bufeixiaojiyin	12-26	NLR family, pyrin domain containing 3	Mus musculus	43-48
35371034-7	2022	Inhibition of the K+/NLRP3/caspase-1/GSDMD pathway abolished T. pyogenes and PLO-induced IL-1beta release.	gsdmd	37-42	NLR family, pyrin domain containing 3	Mus musculus	21-26
35371052-6	2022	Results: The results suggested that DNTs promoted HSC activation and NLRP3 activation.	dnts	36-40	NLR family, pyrin domain containing 3	Mus musculus	69-74
35371052-7	2022	The effect of DNTs on activating HSC-NLRP3-/- was suppressed, and the difference was significant as compared with HSCs.	dnts	14-18	NLR family, pyrin domain containing 3	Mus musculus	37-42
35371052-9	2022	To explore the mechanism of DNT-secreted TNF-alpha in TNFR1-NLRP3 activation, we transfected DNTs with TNF-alpha siRNA; as a result, DNTs with TNF-alpha silencing did not significantly affect HSC activation.	2,6-dinitrotoluene	28-31	NLR family, pyrin domain containing 3	Mus musculus	60-65
35371052-9	2022	To explore the mechanism of DNT-secreted TNF-alpha in TNFR1-NLRP3 activation, we transfected DNTs with TNF-alpha siRNA; as a result, DNTs with TNF-alpha silencing did not significantly affect HSC activation.	dnts	133-137	NLR family, pyrin domain containing 3	Mus musculus	60-65
35371052-10	2022	DNTs promoted hepatic tissue fibrosis progression and HSC activation; after treatment with NLRP3 inhibitor, the effect of DNTs on promoting fibrosis was suppressed.	dnts	122-126	NLR family, pyrin domain containing 3	Mus musculus	91-96
35371052-11	2022	Conclusion: We discovered that DNTs played an important role in liver fibrosis and that DNTs promoted HSC activation via the TNF-alpha-TNFR1-NLRP3 signal axis, thus further promoting liver fibrosis progression.	dnts	88-92	NLR family, pyrin domain containing 3	Mus musculus	141-146
35131329-0	2022	The role of alpha5-nicotinic acetylcholine receptor/NLRP3 signaling pathway in lung adenocarcinoma cell proliferation and migration.	Acetylcholine	29-42	NLR family, pyrin domain containing 3	Mus musculus	52-57
35450356-3	2022	To address these needs, structural optimization of velutone F led to a series of novel NLRP3 inhibitors.	velutone	51-59	NLR family, pyrin domain containing 3	Mus musculus	87-92
35131329-6	2022	In vitro, nicotine increased the levels of alpha5-nAChR, p-STAT3, and NLRP3 inflammasome expression, accompanied by the expression of caspase-1, IL-1beta and IL-18.	Nicotine	10-18	NLR family, pyrin domain containing 3	Mus musculus	70-75
35131329-7	2022	Nicotine-induced activation of p-STAT3 and NLRP3 inflammasome signaling were inhibited by the silencing of alpha5-nAChR.	Nicotine	0-8	NLR family, pyrin domain containing 3	Mus musculus	43-48
35131329-11	2022	Together, these findings reveal a novel nicotine-mediated signaling pathway: nicotine promotes lung cell proliferation and migration via the alpha5-nAChR/STAT3/NLRP3 axis in lung cancer.	Nicotine	40-48	NLR family, pyrin domain containing 3	Mus musculus	160-165
35131329-11	2022	Together, these findings reveal a novel nicotine-mediated signaling pathway: nicotine promotes lung cell proliferation and migration via the alpha5-nAChR/STAT3/NLRP3 axis in lung cancer.	Nicotine	77-85	NLR family, pyrin domain containing 3	Mus musculus	160-165
35244883-0	2022	Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1beta and IL-4/MCP-1 signaling pathways.	diacerein	0-9	NLR family, pyrin domain containing 3	Mus musculus	81-86
35166735-5	2022	Further, FMPH inhibited Th17 cell differentiation, and inhibited inflammasome activation and IL-1beta expression through the NLRP3/ASC/caspase-1 pathway.	fmph	9-13	NLR family, pyrin domain containing 3	Mus musculus	125-130
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	125-161
35369029-10	2022	Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability.	Quercetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	163-168
35233679-7	2022	Mechanistic investigations indicated that PFDA inhibited caspase-1 activation, and decreased the mRNA levels of NLRP1, NLRP3, and NLRC4; thus, suggesting that inflammasome assemblies were suppressed.	perfluorodecanoic acid	42-46	NLR family, pyrin domain containing 3	Mus musculus	119-124
35244883-0	2022	Diacerein counteracts acetaminophen-induced hepatotoxicity in mice via targeting NLRP3/caspase-1/IL-1beta and IL-4/MCP-1 signaling pathways.	Acetaminophen	22-35	NLR family, pyrin domain containing 3	Mus musculus	81-86
35148667-9	2022	Mechanically, miR-135a-5p inhibited TXNIP expression to block the binding of TXNIP and NLRP3.	mir-135a-5p	14-25	NLR family, pyrin domain containing 3	Mus musculus	87-92
35086063-5	2022	The anti-inflammatory mechanism of ABAI-30 was examined and found to be inhibiting the TLR4-pp65 and NLRP3-caspase-1 signaling pathway, thus leading to the downregulation of IL6, IL-1beta and TNFalpha at both transcriptional and translational levels.	ABAI-30	35-42	NLR family, pyrin domain containing 3	Mus musculus	101-106
35063475-0	2022	Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway.	Curcumin	0-8	NLR family, pyrin domain containing 3	Mus musculus	72-77
35119950-0	2022	Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice.	parthenolide	10-22	NLR family, pyrin domain containing 3	Mus musculus	27-32
35222699-0	2022	Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation.	Metformin	0-9	NLR family, pyrin domain containing 3	Mus musculus	88-93
35184679-10	2022	Rapamycin ameliorates renal damage by inhibiting the mTOR/NLRP3 signaling pathway.	Sirolimus	0-9	NLR family, pyrin domain containing 3	Mus musculus	58-63
35228523-8	2022	On one hand, naringenin activated lysosome-dependent inhibition of the NLRP3 inflammasome and repressed aneurysmal inflammation.	naringenin	13-23	NLR family, pyrin domain containing 3	Mus musculus	71-76
35063475-0	2022	Curcumin mitigates aflatoxin B1-induced liver injury via regulating the NLRP3 inflammasome and Nrf2 signaling pathway.	Aflatoxin B1	19-31	NLR family, pyrin domain containing 3	Mus musculus	72-77
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	152-179
35222699-11	2022	Regarding the mechanism, in cartilage, metformin increased the expression of Col II and decreased the expression of MMP-13, NLRP3, caspase-1, GSDMD and IL-1beta.	Metformin	39-48	NLR family, pyrin domain containing 3	Mus musculus	124-129
35222699-13	2022	Overall, metformin inhibited the activation of NLRP3 inflammasome, decreased cartilage degradation, reversed subchondral bone remodelling and inhibited chondrocyte pyroptosis.	Metformin	9-18	NLR family, pyrin domain containing 3	Mus musculus	47-52
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	181-186
35101564-9	2022	H2S donor sodium hydrosulfide (NaHS) improved diabetic cardiomyopathy, attenuated myocardial oxidative stress, necroptosis and the NLR family pyrin domain-containing protein 3 (NLRP3) in db/db mice.	sodium bisulfide	10-29	NLR family, pyrin domain containing 3	Mus musculus	131-175
35063475-10	2022	In addition, curcumin significantly reduced the characteristic indices of AFB1-induced pyroptosis, such as the expression of mRNAs for genes related to NOD-like receptor protein 3 (NLRP3) inflammasome assembly and activation, the expression of key proteins (NLRP3, Caspase-1 and GSDMD).	Curcumin	13-21	NLR family, pyrin domain containing 3	Mus musculus	258-263
35063475-13	2022	To summarize, our results indicated that curcumin could modulate the NLRP3 inflammasome and Nrf2 signaling pathways to attenuate AFB1-induced liver pyroptotic damage and oxidative stress.	Curcumin	41-49	NLR family, pyrin domain containing 3	Mus musculus	69-74
35091064-7	2022	The mechanistic effect of HMGB2 was studied in the 661w cell line treated with H2O2, showing that exogenous recombinant HMGB2 protein reduced the expressions of the antioxidant protein nuclear erythroid factor 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1), and induced NF-kappaB/NLRP3 signaling pathway.	Hydrogen Peroxide	79-83	NLR family, pyrin domain containing 3	Mus musculus	309-314
35101564-9	2022	H2S donor sodium hydrosulfide (NaHS) improved diabetic cardiomyopathy, attenuated myocardial oxidative stress, necroptosis and the NLR family pyrin domain-containing protein 3 (NLRP3) in db/db mice.	sodium bisulfide	10-29	NLR family, pyrin domain containing 3	Mus musculus	177-182
35101564-9	2022	H2S donor sodium hydrosulfide (NaHS) improved diabetic cardiomyopathy, attenuated myocardial oxidative stress, necroptosis and the NLR family pyrin domain-containing protein 3 (NLRP3) in db/db mice.	sodium bisulfide	31-35	NLR family, pyrin domain containing 3	Mus musculus	131-175
35101564-9	2022	H2S donor sodium hydrosulfide (NaHS) improved diabetic cardiomyopathy, attenuated myocardial oxidative stress, necroptosis and the NLR family pyrin domain-containing protein 3 (NLRP3) in db/db mice.	sodium bisulfide	31-35	NLR family, pyrin domain containing 3	Mus musculus	177-182
35101564-11	2022	In Conclusion, H2S deficiency aggravated mitochondrial damage, increased reactive oxygen species accumulation, promoted necroptosis, activated NLRP3 inflammasome, and finally exacerbated diabetic cardiomyopathy.	Deuterium	15-18	NLR family, pyrin domain containing 3	Mus musculus	143-148
35101564-12	2022	Exogenous H2S supplementation alleviated necroptosis to suppress NLRP3 inflammasome activation and attenuate diabetic cardiomyopathy via mitochondrial dysfunction improvement and oxidative stress inhibition.	Deuterium	10-13	NLR family, pyrin domain containing 3	Mus musculus	65-70
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	0-45	NLR family, pyrin domain containing 3	Mus musculus	160-165
35008006-6	2022	Suppressing ROS with N-acetylcysteine (NAC) or interfering with NOX2 by small interfering RNA weakened the promoting effect of CTRP9 on the NLRP3 inflammasome.	Reactive Oxygen Species	12-15	NLR family, pyrin domain containing 3	Mus musculus	140-145
35008006-6	2022	Suppressing ROS with N-acetylcysteine (NAC) or interfering with NOX2 by small interfering RNA weakened the promoting effect of CTRP9 on the NLRP3 inflammasome.	Acetylcysteine	39-42	NLR family, pyrin domain containing 3	Mus musculus	140-145
35008006-10	2022	In conclusion, our study indicates that CTRP9 aggravates LPS-induced inflammation by promoting NLRP3 inflammasome activation via the NOX2/ROS pathway.	Reactive Oxygen Species	138-141	NLR family, pyrin domain containing 3	Mus musculus	95-100
35084779-8	2022	Crocin improved neuroinflammation by inhibiting the increase in reactive microglia and astrocytes, weakening NLRP3 inflammasome activation accompanied by a reduction in Caspase-1 and IL-1beta, and blocking TLR4 signaling accompanied by a decrease in NF-kB p65 and MyD88.	crocin	0-6	NLR family, pyrin domain containing 3	Mus musculus	109-114
35084779-10	2022	These findings provide experimental support that crocin attenuates cognitive impairment associated with atherosclerosis by repressing neuroinflammation, which is attributed to its suppression on the activation of microglia and astrocytes, and the production of inflammatory cytokines via targeting the NLRP3 inflammasome and TLR4 signaling.	crocin	49-55	NLR family, pyrin domain containing 3	Mus musculus	302-307
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	Polyphenols	0-10	NLR family, pyrin domain containing 3	Mus musculus	110-115
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	dss	54-57	NLR family, pyrin domain containing 3	Mus musculus	110-115
35326124-10	2022	In conclusion, we found that Forsythia suspensa extract significantly alleviated DSS-induced UC injury through the Nrf2-NLRP3 pathway and relieved metabolic dysfunction.	dss	81-84	NLR family, pyrin domain containing 3	Mus musculus	120-125
35224772-0	2022	Kakonein restores hyperglycemia-induced macrophage digestion dysfunction through regulation of cathepsin B-dependent NLRP3 inflammasome activation.	puerarin	0-8	NLR family, pyrin domain containing 3	Mus musculus	117-122
35224772-6	2022	Meanwhile, kakonein could decrease NLRP3 inflammasome products expression and NLRP3/ASC or NLRP3/Casp1 colocalization in macrophage.	puerarin	11-19	NLR family, pyrin domain containing 3	Mus musculus	35-40
35224772-6	2022	Meanwhile, kakonein could decrease NLRP3 inflammasome products expression and NLRP3/ASC or NLRP3/Casp1 colocalization in macrophage.	puerarin	11-19	NLR family, pyrin domain containing 3	Mus musculus	78-83
35224772-6	2022	Meanwhile, kakonein could decrease NLRP3 inflammasome products expression and NLRP3/ASC or NLRP3/Casp1 colocalization in macrophage.	puerarin	11-19	NLR family, pyrin domain containing 3	Mus musculus	91-96
35000152-10	2022	Notes: The upregulation of P2Y12 receptor expression and the activation of SGCs lead to the increase of ROS content in vivo, followed by the activation of NLRP3 inflammasome, the increase of inflammatory cytokine release, the abnormal excitation of DRG neurons, and the damage of peripheral nerves, resulting in chronic itching.	Reactive Oxygen Species	104-107	NLR family, pyrin domain containing 3	Mus musculus	155-160
35247669-10	2022	The results showed that ICA-induced NLRP3 suppression and mitophagy vanished.	icariin	24-27	NLR family, pyrin domain containing 3	Mus musculus	36-41
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	47-51	NLR family, pyrin domain containing 3	Mus musculus	160-165
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	Benzo(a)pyrene	76-90	NLR family, pyrin domain containing 3	Mus musculus	144-149
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	Leucine	109-116	NLR family, pyrin domain containing 3	Mus musculus	160-165
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	ros	130-133	NLR family, pyrin domain containing 3	Mus musculus	144-149
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion	220-274	NLR family, pyrin domain containing 3	Mus musculus	160-165
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	ros	116-119	NLR family, pyrin domain containing 3	Mus musculus	130-135
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	Benzo(a)pyrene	157-160	NLR family, pyrin domain containing 3	Mus musculus	130-135
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	mangion-purified polysaccharide (Candida albicans)	276-280	NLR family, pyrin domain containing 3	Mus musculus	160-165
35085893-1	2022	1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) can activate nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 (NLRP3) inflammasome in Parkinson"s disease (PD) mice, while 1-methyl-4-phenyl- 1, 2, 3, 6-tetrahydropyridinium ion (MPP+), the toxic metabolite of MPTP was not enough to achieve it in vitro.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	307-311	NLR family, pyrin domain containing 3	Mus musculus	160-165
35085893-2	2022	We hypothesized that the accumulation of Alpha-synuclein (alpha-syn) caused by MPP+ can be a priming signal of MPP+ mediated NLRP3 activation, and its mechanism was explored.	mangion-purified polysaccharide (Candida albicans)	79-83	NLR family, pyrin domain containing 3	Mus musculus	125-130
35085893-5	2022	The co-treatment of alpha-syn/MPP+ can cause aberrant mitochondrial homeostasis to diminish the concentration of the coenzyme nicotinamide adenine dinucleotide (NAD+), mediate accumulation of ac-alpha-tubulin, and induce mitochondrial perinuclear aggregation, navigating the co-localization of NLRP3 and apoptosis-associated speck-like protein containing a CARD domain (ASC).	NAD	161-165	NLR family, pyrin domain containing 3	Mus musculus	294-299
35281058-7	2022	The intracellular calcium (Ca2+) level was decreased by HSC via the PIP2 signaling pathway, which subsequently inhibited the activation of NLRP3 inflammasome.	Phosphatidylinositol 4,5-Diphosphate	68-72	NLR family, pyrin domain containing 3	Mus musculus	139-144
35217818-11	2022	In vitro, N-acetylcysteine (NAC) inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression, in MOVAS cells treated with TNF-alpha.	Acetylcysteine	10-26	NLR family, pyrin domain containing 3	Mus musculus	43-48
35217818-11	2022	In vitro, N-acetylcysteine (NAC) inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression, in MOVAS cells treated with TNF-alpha.	Acetylcysteine	28-31	NLR family, pyrin domain containing 3	Mus musculus	43-48
35217818-11	2022	In vitro, N-acetylcysteine (NAC) inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression, in MOVAS cells treated with TNF-alpha.	Acetylcysteine	28-31	NLR family, pyrin domain containing 3	Mus musculus	77-82
35132999-0	2022	Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway.	Buformin	0-8	NLR family, pyrin domain containing 3	Mus musculus	68-73
35281058-0	2022	Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-kappaB/NLRP3 Signaling Pathway.	hederacoside C	0-15	NLR family, pyrin domain containing 3	Mus musculus	120-125
35281058-11	2022	Interestingly, the PIP2/NF-kappaB/NLRP3 signaling pathway was further confirmed by the treatment of HSC with ALI, which is consistent with the treatment of HSC with LPS/LPS+ATP-stimulated macrophages.	Adenosine Triphosphate	173-176	NLR family, pyrin domain containing 3	Mus musculus	34-39
35281058-3	2022	These two pathways are interconnected and share a common inducer the phosphatidylinositol 4,5-bisphosphate (PIP2), an epigenetic regulator of (Ribosomal ribonucleic acid (rRNA) gene transcription, to regulate inflammation by the direct inhibition of NF-kappaB phosphorylation and NLRP3 inflammasome activation.	Phosphatidylinositol 4,5-Diphosphate	69-106	NLR family, pyrin domain containing 3	Mus musculus	280-285
35281058-3	2022	These two pathways are interconnected and share a common inducer the phosphatidylinositol 4,5-bisphosphate (PIP2), an epigenetic regulator of (Ribosomal ribonucleic acid (rRNA) gene transcription, to regulate inflammation by the direct inhibition of NF-kappaB phosphorylation and NLRP3 inflammasome activation.	Phosphatidylinositol 4,5-Diphosphate	108-112	NLR family, pyrin domain containing 3	Mus musculus	280-285
35281058-4	2022	Herein, we report that hederasaponin C (HSC) exerted a therapeutic effect against ALI through the regulation of the PIP2/NF-kappaB/NLRP3 signaling pathway.	hederacoside C	23-38	NLR family, pyrin domain containing 3	Mus musculus	131-136
35284463-0	2022	Berberine Ameliorates Inflammation in Acute Lung Injury via NF-kappaB/Nlrp3 Signaling Pathway.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	70-75
35284463-5	2022	We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-kappaB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3).	Berberine	21-24	NLR family, pyrin domain containing 3	Mus musculus	210-215
35195182-0	2022	Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation.	peoniflorin	0-12	NLR family, pyrin domain containing 3	Mus musculus	64-69
35284463-5	2022	We demonstrated that BBR could suppress the expression of phosphorylated nuclear factor-kappa B (NF-kappaB) and further restrain the downstream gene nucleotide-binding domain and leucine-rich repeat protein-3 (Nlrp3).	Leucine	179-186	NLR family, pyrin domain containing 3	Mus musculus	210-215
35284463-7	2022	After knocked down of Nlrp3 by using siRNA, the protective role of BBR was abrogated in vitro.	Berberine	67-70	NLR family, pyrin domain containing 3	Mus musculus	22-27
35284463-9	2022	Notably, in Nlrp3 deficient mice, the protective effect of BBR was abolished.	Berberine	59-62	NLR family, pyrin domain containing 3	Mus musculus	12-17
35194060-0	2022	Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy.	(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid	0-11	NLR family, pyrin domain containing 3	Mus musculus	23-28
35281058-4	2022	Herein, we report that hederasaponin C (HSC) exerted a therapeutic effect against ALI through the regulation of the PIP2/NF-kappaB/NLRP3 signaling pathway.	N-hydroxy-N-succinylcadaverine	40-43	NLR family, pyrin domain containing 3	Mus musculus	131-136
35281058-7	2022	The intracellular calcium (Ca2+) level was decreased by HSC via the PIP2 signaling pathway, which subsequently inhibited the activation of NLRP3 inflammasome.	Calcium	18-25	NLR family, pyrin domain containing 3	Mus musculus	139-144
35195182-11	2022	PA could also significantly up-regulate SOD and GSH-px levels (p<0.01), down-regulate IL-1beta, IL-18, caspase-1, NLRP3, and TNF-alpha protein or gene expression in PBC mice (p<0.01) and inhibit liver fibrosis levels (p<0.01).	peoniflorin	0-2	NLR family, pyrin domain containing 3	Mus musculus	114-119
35195182-12	2022	CONCLUSIONS: PA can reduce PBC-induced liver fibrosis in mice and may function by curbing the formation of NLRP3.	peoniflorin	13-15	NLR family, pyrin domain containing 3	Mus musculus	107-112
35252186-0	2022	Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis.	manoalide	51-60	NLR family, pyrin domain containing 3	Mus musculus	18-23
35252186-2	2022	Through screening the small molecule library, we found that manoalide is a highly selective small molecule inhibitor of NLRP3.	manoalide	60-69	NLR family, pyrin domain containing 3	Mus musculus	120-125
35252186-3	2022	Mechanismly, manoalide inhibited the NLRP3 inflammasome activation by acting downstream of potassium efflux, chloride efflux and mitochondrial dysfunction.	manoalide	13-22	NLR family, pyrin domain containing 3	Mus musculus	37-42
35252186-3	2022	Mechanismly, manoalide inhibited the NLRP3 inflammasome activation by acting downstream of potassium efflux, chloride efflux and mitochondrial dysfunction.	Potassium	91-100	NLR family, pyrin domain containing 3	Mus musculus	37-42
35252186-3	2022	Mechanismly, manoalide inhibited the NLRP3 inflammasome activation by acting downstream of potassium efflux, chloride efflux and mitochondrial dysfunction.	Chlorides	109-117	NLR family, pyrin domain containing 3	Mus musculus	37-42
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	manoalide	10-19	NLR family, pyrin domain containing 3	Mus musculus	61-66
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	manoalide	10-19	NLR family, pyrin domain containing 3	Mus musculus	107-112
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	Lysine	92-95	NLR family, pyrin domain containing 3	Mus musculus	61-66
35252186-4	2022	Moreover, manoalide blocked the interaction between NEK7 and NLRP3 by covalently binding to Lys 377 of the NLRP3 protein.	Lysine	92-95	NLR family, pyrin domain containing 3	Mus musculus	107-112
35252186-6	2022	Thus, our results identify manoalide as a selective and covalent NLRP3 inhibitor and suggest it has the potential for the treatment of NLRP3-associated diseases.	manoalide	27-36	NLR family, pyrin domain containing 3	Mus musculus	65-70
35252186-6	2022	Thus, our results identify manoalide as a selective and covalent NLRP3 inhibitor and suggest it has the potential for the treatment of NLRP3-associated diseases.	manoalide	27-36	NLR family, pyrin domain containing 3	Mus musculus	135-140
35222363-0	2022	Idebenone Regulates Abeta and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1beta Axis Activation.	idebenone	0-9	NLR family, pyrin domain containing 3	Mus musculus	100-105
34999086-0	2022	Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.	homoorientin	0-11	NLR family, pyrin domain containing 3	Mus musculus	109-114
34999086-10	2022	Meanwhile, the results of molecular docking indicated the potential ability of ISO as a ligand binding with proteins Keap1, NLRP3 and cleaved-caspase-3 as well.	homoorientin	79-82	NLR family, pyrin domain containing 3	Mus musculus	124-129
35152824-5	2022	WT mice injected with irinotecan presented a progressive increase in mtDNA in the serum along with increased hematocrit, shortening of small intestine length, reduction of intestinal villus:crypt ratio and increased influx of neutrophils, which were followed by higher expression of Nlrp3 and Casp1 mRNA and increased IL-1beta levels in the ileum when compared to vehicle-injected mice.	Irinotecan	22-32	NLR family, pyrin domain containing 3	Mus musculus	283-288
35152824-8	2022	Overall, our findings show that the amount of circulating free CpG-DNA is increased upon chemotherapy and that TLR9 activation is important for NLRP3 inflammasome transcription and further IL-1beta release, playing a central role in the development of irinotecan-induced intestinal mucositis.	Irinotecan	252-262	NLR family, pyrin domain containing 3	Mus musculus	144-149
35185385-0	2022	Glibenclamide Alleviates LPS-Induced Acute Lung Injury through NLRP3 Inflammasome Signaling Pathway.	Glyburide	0-13	NLR family, pyrin domain containing 3	Mus musculus	63-68
35185385-4	2022	Meanwhile, the increased proteins of NLRP3 and Caspase-1/p20 after LPS instillation in lungs were downregulated by glibenclamide.	Glyburide	115-128	NLR family, pyrin domain containing 3	Mus musculus	37-42
35185385-5	2022	Similarly, in vitro experiments also found that glibenclamide administration inhibited the LPS-induced upregulations in cytokine secretions of IL-1beta and IL-18, as well as in the expression of components in NLRP3 inflammasome in mouse peritoneal macrophages.	Glyburide	48-61	NLR family, pyrin domain containing 3	Mus musculus	209-214
35185385-7	2022	In conclusion, glibenclamide alleviates the development of LPS-induced ALI in a mouse model via inhibiting the NLRP3/Caspase-1/IL-1beta signaling pathway, which might provide a new strategy for the treatment of LPS-induced ALI.	Glyburide	15-28	NLR family, pyrin domain containing 3	Mus musculus	111-116
35222363-4	2022	In male and female WT mice, idebenone upregulated neuroprotective NRF2 expression, rescued LPS-induced spatial and recognition memory impairments, and reduced NLRP3 priming and subsequent neuroinflammation.	idebenone	28-37	NLR family, pyrin domain containing 3	Mus musculus	159-164
35222363-5	2022	Moreover, idebenone downregulated LPS-mediated neurogliosis, reactive oxygen species (ROS) levels, and mitochondrial function in BV2 microglial cells and primary astrocytes by inhibiting NLRP3 inflammasome activation.	idebenone	10-19	NLR family, pyrin domain containing 3	Mus musculus	187-192
35222363-7	2022	Idebenone downregulated Abeta-mediated gliosis and proinflammatory cytokine levels in 5xFAD mice by modulating the vicious NLRP3/caspase-1/IL-1beta neuroinflammation cycle.	idebenone	0-9	NLR family, pyrin domain containing 3	Mus musculus	123-128
35222363-8	2022	Taken together, our results suggest that idebenone targets neuroglial NLRP3 inflammasome activation and therefore may have neuroprotective effects and inhibit the pathological progression of neuroinflammation-related diseases.	idebenone	41-50	NLR family, pyrin domain containing 3	Mus musculus	70-75
35143820-6	2022	Furthermore, in mice with imiquimod-induced psoriasis-like dermatitis, topical application of AhR small-interfering RNA substantially exacerbated the disease severity with increased NLRP3 inflammasome activation.	Imiquimod	26-35	NLR family, pyrin domain containing 3	Mus musculus	182-187
35204211-3	2022	Nigras from aged rats and mice and 6-hydroxydopamine PD models showed upregulation in transcription of inflammasome-related components (NLRP3, pro-IL1beta and pro-IL18) and IL1beta and IL18 protein levels, which was inhibited by the AT1 receptor antagonist candesartan.	Oxidopamine	35-52	NLR family, pyrin domain containing 3	Mus musculus	136-141
35120573-5	2022	Moreover, knockdown of TLR9 could restrain NF-kB viability and downregulate the NLRP3 inflammasome in high glucose-treated MCs.	Glucose	107-114	NLR family, pyrin domain containing 3	Mus musculus	80-85
34706199-10	2022	Cd38 /  macrophages displayed markedly increased activation of Btk, NF-KappaB, and NLRP3 whereas in vivo administration of the Btk inhibitor ibrutinib (a FDA approved drug) prevented augmented TLR4-induced inflammatory lung injury seen in Cd38 /  mice.	ibrutinib	141-150	NLR family, pyrin domain containing 3	Mus musculus	83-88
35106716-0	2022	Leonurine attenuates cisplatin nephrotoxicity by suppressing the NLRP3 inflammasome, mitochondrial dysfunction, and endoplasmic reticulum stress.	leonurine	0-9	NLR family, pyrin domain containing 3	Mus musculus	65-70
35106716-14	2022	Expression of nucleotide-binding leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome components and inflammatory cytokines, mitochondrial dysfunction, and ERS were all alleviated by leonurine.	Leucine	33-40	NLR family, pyrin domain containing 3	Mus musculus	92-97
35106716-14	2022	Expression of nucleotide-binding leucine-rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome components and inflammatory cytokines, mitochondrial dysfunction, and ERS were all alleviated by leonurine.	leonurine	209-218	NLR family, pyrin domain containing 3	Mus musculus	92-97
34427642-6	2022	The Caco-2 cells and the colon tissues of DSS-treated mice were collected for analysis of the expression levels of inflammatory cytokines, NLRP3 inflammasome, and autophagy-related proteins.	Dextran Sulfate	42-45	NLR family, pyrin domain containing 3	Mus musculus	139-144
35043135-7	2022	Our results also showed that GSPE administration could downregulate the NLRP3 inflammasome signaling pathway for inhibiting inflammation levels in the brain tissue.	gspe	29-33	NLR family, pyrin domain containing 3	Mus musculus	72-77
34999177-5	2022	In the study of mechanism, we found that alliin might reduce the activation of NLRP3 inflammosome by decreasing intracellular ROS generation.	ros	126-129	NLR family, pyrin domain containing 3	Mus musculus	79-84
34998273-7	2022	CS induced the expression of HSP60 in the COPD mouse model, accelerated the activation of toll-like receptor 4 (TLR4) and NLR family pyrin domain containing 3 (NLRP3) signalling pathways, promoted the increase of inflammatory cells in alveolar lavage fluid and serum inflammatory factors, and induced destruction of lung tissue structure.	Cesium	0-2	NLR family, pyrin domain containing 3	Mus musculus	122-158
34984827-0	2022	Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition.	Berberine	0-9	NLR family, pyrin domain containing 3	Mus musculus	122-127
34998273-7	2022	CS induced the expression of HSP60 in the COPD mouse model, accelerated the activation of toll-like receptor 4 (TLR4) and NLR family pyrin domain containing 3 (NLRP3) signalling pathways, promoted the increase of inflammatory cells in alveolar lavage fluid and serum inflammatory factors, and induced destruction of lung tissue structure.	Cesium	0-2	NLR family, pyrin domain containing 3	Mus musculus	160-165
34998273-9	2022	Our study revealed that CS stimulates the expression of HSP60, activating the TLR4-MyD88-NF-kappaB signalling pathway and the NLRP3 inflammasome.	Cesium	24-26	NLR family, pyrin domain containing 3	Mus musculus	126-131
35050445-0	2022	Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer"s disease.	ginkgolide B	0-12	NLR family, pyrin domain containing 3	Mus musculus	29-34
35050445-3	2022	The aim of this study was to evaluate the effect of GB on the NLRP3 inflammasome in AD.	ginkgolide B	52-54	NLR family, pyrin domain containing 3	Mus musculus	62-67
35050445-5	2022	Western blotting assays and ELISA were used to detect changes in neuro-inflammation following GB treatment, including the NLRP3 inflammasome pathway and autophagy.	ginkgolide B	94-96	NLR family, pyrin domain containing 3	Mus musculus	122-127
35050445-8	2022	Moreover, GB deactivated the NLRP3 inflammasome, and this effect was dependent on autophagy.	ginkgolide B	10-12	NLR family, pyrin domain containing 3	Mus musculus	29-34
35050445-9	2022	Ubiquitination was associated with GB-induced autophagic NLRP3 degradation.	ginkgolide B	35-37	NLR family, pyrin domain containing 3	Mus musculus	57-62
35050445-11	2022	Thus, GB exerted a neuroprotective effect on the cognitive function of SAMP8 mice by suppressing the activation of NLRP3 inflammasome via autophagic degradation.	ginkgolide B	6-8	NLR family, pyrin domain containing 3	Mus musculus	115-120
34998855-0	2022	Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations.	Curcumin	11-19	NLR family, pyrin domain containing 3	Mus musculus	76-81
34998855-0	2022	Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations.	Dexamethasone	24-37	NLR family, pyrin domain containing 3	Mus musculus	76-81
34998855-0	2022	Intranasal curcumin and dexamethasone combination ameliorates inflammasome (NLRP3) activation in lipopolysachharide exposed asthma exacerbations.	lipopolysachharide	97-115	NLR family, pyrin domain containing 3	Mus musculus	76-81
34998855-2	2022	Present study is undertaken to investigate anti-inflammatory effects of a well known phytochemical, curcumin, which might regulate LPS exposed asthma exacerbations by modulating NLRP3 activation if given through intranasal route.	Curcumin	100-108	NLR family, pyrin domain containing 3	Mus musculus	178-183
35130622-5	2022	Unexpectedly, gossypol-induced necrosis is independent of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as neither inhibitor for the NLRP3 pathway nor NLRP3 deficiency protects the macrophages from the necrosis.	Gossypol	14-22	NLR family, pyrin domain containing 3	Mus musculus	148-153
34923585-0	2022	Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice.	Disulfiram	0-10	NLR family, pyrin domain containing 3	Mus musculus	105-110
35020848-3	2022	TSLPR signals through Janus kinase (JAK)2, but not JAK1 or JAK3, to induce NLRP3 expression, and Tslpr -/- mice with EAE show decreased JAK2 phosphorylation and NLRP3 expression in the brain.	EAE	117-120	NLR family, pyrin domain containing 3	Mus musculus	161-166
35203954-7	2022	Interestingly, further investigations revealed that gelsemine inhibited the CUMS-induced activation of NLRP3-inflammasome pathways and downregulated CREB and BDNF overexpression in the hypothalamus.	gelsemine	52-61	NLR family, pyrin domain containing 3	Mus musculus	103-108
35203954-7	2022	Interestingly, further investigations revealed that gelsemine inhibited the CUMS-induced activation of NLRP3-inflammasome pathways and downregulated CREB and BDNF overexpression in the hypothalamus.	cums	76-80	NLR family, pyrin domain containing 3	Mus musculus	103-108
35203954-9	2022	Gelsemine exerted its anxiolytic effects by modulating the NLRP3 and CREB/BDNF pathways.	gelsemine	0-9	NLR family, pyrin domain containing 3	Mus musculus	59-64
35153783-12	2022	Our results suggested that daphnetin is likely to be a candidate drug for premature ovarian failure treatment and it is mostly possible referred to the molecular mechanism of increasing Nrf2 expression and inhibiting NLRP3 activation in the ovarian aging process.	daphnetin	27-36	NLR family, pyrin domain containing 3	Mus musculus	217-222
35130622-5	2022	Unexpectedly, gossypol-induced necrosis is independent of nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, as neither inhibitor for the NLRP3 pathway nor NLRP3 deficiency protects the macrophages from the necrosis.	Gossypol	14-22	NLR family, pyrin domain containing 3	Mus musculus	216-221
35079027-0	2022	NLRP3 inflammasome in rosmarinic acid-afforded attenuation of acute kidney injury in mice.	rosmarinic acid	22-37	NLR family, pyrin domain containing 3	Mus musculus	0-5
34874278-2	2022	The deubiquitinase BRCA1-BRCA2-containing complex subunit 3 (BRCC3)-mediated nucleotide-binding domain and leucine-rich repeat receptor containing a pyrin domain 3 (NLRP3) inflammasome activation participates in this progress.	Leucine	107-114	NLR family, pyrin domain containing 3	Mus musculus	165-170
35079027-7	2022	Treatment of RA inhibited the activation of NLRP3 signaling pathway by blocking the activated caspase-1 and downstream signal molecules such as IL-1beta and IL18.	rosmarinic acid	13-15	NLR family, pyrin domain containing 3	Mus musculus	44-49
35127716-0	2021	Sevoflurane Aggravates the Progress of Alzheimer"s Disease Through NLRP3/Caspase-1/Gasdermin D Pathway.	Sevoflurane	0-11	NLR family, pyrin domain containing 3	Mus musculus	67-72
35126159-0	2022	Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome.	fisetin	0-7	NLR family, pyrin domain containing 3	Mus musculus	78-83
35126159-6	2022	Furthermore, fisetin suppressed the phosphorylation of P70S6K, a downstream target of CDKN1B, activated autophagosome formation, and inhibited Nod-like receptor protein 3 (NLRP3) inflammasomes.	fisetin	13-20	NLR family, pyrin domain containing 3	Mus musculus	143-170
35126159-6	2022	Furthermore, fisetin suppressed the phosphorylation of P70S6K, a downstream target of CDKN1B, activated autophagosome formation, and inhibited Nod-like receptor protein 3 (NLRP3) inflammasomes.	fisetin	13-20	NLR family, pyrin domain containing 3	Mus musculus	172-177
35127716-8	2021	The nontoxic caspase-1 small-molecule inhibitor VX-765 significantly inhibited this activation process in microglia, while NLRP3 deletion suppressed sevoflurane-induced caspase-1 cleavage and subsequently pyroptosis, as well as tau pathology.	Sevoflurane	149-160	NLR family, pyrin domain containing 3	Mus musculus	123-128
35127716-10	2021	Conclusion: This study is the first to report that clinical doses of sevoflurane aggravate the progression of AD via the NLRP3/caspase-1/GSDMD axis.	Sevoflurane	69-80	NLR family, pyrin domain containing 3	Mus musculus	121-126
35126093-12	2021	Our study highlights the importance of NLRP3 inflammasome-mediated pyroptosis in AD, and how the administration of pharmacological doses of Sal can inhibit NLRP3 inflammasome-mediated pyroptosis and ameliorate AD.	rhodioloside	140-143	NLR family, pyrin domain containing 3	Mus musculus	39-44
35126093-12	2021	Our study highlights the importance of NLRP3 inflammasome-mediated pyroptosis in AD, and how the administration of pharmacological doses of Sal can inhibit NLRP3 inflammasome-mediated pyroptosis and ameliorate AD.	rhodioloside	140-143	NLR family, pyrin domain containing 3	Mus musculus	156-161
35079379-0	2022	TGF-beta-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-alpha and RANKL expression.	LL Z1640-2	38-48	NLR family, pyrin domain containing 3	Mus musculus	151-156
35079379-10	2022	LLZ could block the priming and activation of NLRP3 inflammasome in RAW264.7 macrophage cell line, primary bone marrow macrophages and OCs upon treatment with LPS followed by ATP, thereby suppressing their IL-1beta production.	Adenosine Triphosphate	175-178	NLR family, pyrin domain containing 3	Mus musculus	46-51
35127716-11	2021	Collectively, our findings elucidate the crucial mechanisms of NLRP3/caspase-1 in pyroptosis and tau pathogenesis induced by sevoflurane and suggest that VX-765 could represent a novel therapeutic intervention for treating AD.	Sevoflurane	125-136	NLR family, pyrin domain containing 3	Mus musculus	63-68
35127716-6	2021	Results: Sevoflurane directly activated caspase-1 to induce pyroptosis in the mouse model of AD via NLRP3 and AIM2 activation.	Sevoflurane	9-20	NLR family, pyrin domain containing 3	Mus musculus	100-105
35127716-11	2021	Collectively, our findings elucidate the crucial mechanisms of NLRP3/caspase-1 in pyroptosis and tau pathogenesis induced by sevoflurane and suggest that VX-765 could represent a novel therapeutic intervention for treating AD.	belnacasan	154-160	NLR family, pyrin domain containing 3	Mus musculus	63-68
35115927-0	2021	Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome.	micheliolide	21-33	NLR family, pyrin domain containing 3	Mus musculus	111-116
35017318-0	2022	Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways.	Atorvastatin	0-12	NLR family, pyrin domain containing 3	Mus musculus	24-29
35111047-5	2021	Notably, our results indicated that NF-kappaB/NLRP3 and autophagy pathways may contribute to pharmacological effects associated with QFY-based protection.	qfy	133-136	NLR family, pyrin domain containing 3	Mus musculus	46-51
35057549-0	2022	Krill Oil Inhibits NLRP3 Inflammasome Activation in the Prevention of the Pathological Injuries of Diabetic Cardiomyopathy.	krill oil	0-9	NLR family, pyrin domain containing 3	Mus musculus	19-24
35096901-0	2021	Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy.	oridonin	0-8	NLR family, pyrin domain containing 3	Mus musculus	57-62
35022542-4	2022	We showed that SA (5-20 muM) suppressed the phosphorylated activation of NF-kappaB in a dose-dependent manner, thereby inhibiting the expression and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and pyroptosis in LPS/ATP-treated mouse bone marrow-derived primary macrophages (BMDMs).	sa	15-17	NLR family, pyrin domain containing 3	Mus musculus	167-194
35022542-4	2022	We showed that SA (5-20 muM) suppressed the phosphorylated activation of NF-kappaB in a dose-dependent manner, thereby inhibiting the expression and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and pyroptosis in LPS/ATP-treated mouse bone marrow-derived primary macrophages (BMDMs).	sa	15-17	NLR family, pyrin domain containing 3	Mus musculus	196-201
35022542-4	2022	We showed that SA (5-20 muM) suppressed the phosphorylated activation of NF-kappaB in a dose-dependent manner, thereby inhibiting the expression and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and pyroptosis in LPS/ATP-treated mouse bone marrow-derived primary macrophages (BMDMs).	Adenosine Triphosphate	238-241	NLR family, pyrin domain containing 3	Mus musculus	167-194
35022542-4	2022	We showed that SA (5-20 muM) suppressed the phosphorylated activation of NF-kappaB in a dose-dependent manner, thereby inhibiting the expression and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome and pyroptosis in LPS/ATP-treated mouse bone marrow-derived primary macrophages (BMDMs).	Adenosine Triphosphate	238-241	NLR family, pyrin domain containing 3	Mus musculus	196-201
35022542-7	2022	The in vivo assessments conducted on mice pretreated with SA (25, 50 mg/kg, ip) then with a single dose of APAP (400 mg/kg, ip) showed that SA significantly alleviated inflammatory responses of AILI by inhibiting the expression and activation of the NLRP3 inflammasome.	Acetaminophen	107-111	NLR family, pyrin domain containing 3	Mus musculus	250-255
35022542-7	2022	The in vivo assessments conducted on mice pretreated with SA (25, 50 mg/kg, ip) then with a single dose of APAP (400 mg/kg, ip) showed that SA significantly alleviated inflammatory responses of AILI by inhibiting the expression and activation of the NLRP3 inflammasome.	sa	140-142	NLR family, pyrin domain containing 3	Mus musculus	250-255
35017318-3	2022	In this study, we examined the impact of atorvastatin on the NOD-like receptor protein 3 (NLRP3) inflammasome and inflammatory pathways following ICH.	Atorvastatin	41-53	NLR family, pyrin domain containing 3	Mus musculus	61-88
35017318-3	2022	In this study, we examined the impact of atorvastatin on the NOD-like receptor protein 3 (NLRP3) inflammasome and inflammatory pathways following ICH.	Atorvastatin	41-53	NLR family, pyrin domain containing 3	Mus musculus	90-95
35017318-10	2022	For inflammasomes, atorvastatin also showed its efficacy by decreasing the expression of NLRP3, cleaved caspase-1, and IL-1beta in ICH mice.	Atorvastatin	19-31	NLR family, pyrin domain containing 3	Mus musculus	89-94
35069768-12	2022	Conclusions: Liquiritin attenuates depression-like behavior of CUMS mice and inhibited cytokines levels triggered by NLRP3 inflammasome, suggesting the antidepressant action is, at least partially, associated with antioxidant stress and inhibition of NLRP3 inflammasome activation.	liquiritin	13-23	NLR family, pyrin domain containing 3	Mus musculus	117-122
35069768-12	2022	Conclusions: Liquiritin attenuates depression-like behavior of CUMS mice and inhibited cytokines levels triggered by NLRP3 inflammasome, suggesting the antidepressant action is, at least partially, associated with antioxidant stress and inhibition of NLRP3 inflammasome activation.	liquiritin	13-23	NLR family, pyrin domain containing 3	Mus musculus	251-256
35069768-0	2022	Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus.	liquiritin	0-10	NLR family, pyrin domain containing 3	Mus musculus	95-100
35069768-2	2022	We investigated whether liquiritin exerts antidepressant effects by inhibiting central NLRP3 inflammasomes.	liquiritin	24-34	NLR family, pyrin domain containing 3	Mus musculus	87-92
35069768-9	2022	Further, liquiritin downregulated the expression of NLRP3 in the hippocampus of CUMS mice rather than TLR4.	liquiritin	9-19	NLR family, pyrin domain containing 3	Mus musculus	52-57
35017318-11	2022	Moreover, atorvastatin markedly inhibited the upregulation of toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88), which indicated deactivation of NLRP3 inflammasomes.	Atorvastatin	10-22	NLR family, pyrin domain containing 3	Mus musculus	169-174
35013155-8	2022	PGC-1alpha induction with the plasmid and metformin improved mitochondrial dynamics and morphology and attenuated the NLRP3 inflammasome and cell injury.	Metformin	42-51	NLR family, pyrin domain containing 3	Mus musculus	118-123
35035661-9	2022	Interestingly, treatment with CoQ0 or Mito-TEMPO, but not NAC, significantly increased LPS/ATP-induced LC3-II accumulation indicating that mitophagy plays a key role in the regulation of CoQ0-inhibited NLRP3 inflammasome activation.	MitoTEMPO	38-48	NLR family, pyrin domain containing 3	Mus musculus	202-207
35035661-0	2022	Coenzyme Q0 Inhibits NLRP3 Inflammasome Activation through Mitophagy Induction in LPS/ATP-Stimulated Macrophages.	ubiquinone-O	0-11	NLR family, pyrin domain containing 3	Mus musculus	21-26
35035661-9	2022	Interestingly, treatment with CoQ0 or Mito-TEMPO, but not NAC, significantly increased LPS/ATP-induced LC3-II accumulation indicating that mitophagy plays a key role in the regulation of CoQ0-inhibited NLRP3 inflammasome activation.	ubiquinone-O	30-34	NLR family, pyrin domain containing 3	Mus musculus	202-207
35035661-9	2022	Interestingly, treatment with CoQ0 or Mito-TEMPO, but not NAC, significantly increased LPS/ATP-induced LC3-II accumulation indicating that mitophagy plays a key role in the regulation of CoQ0-inhibited NLRP3 inflammasome activation.	Adenosine Triphosphate	91-94	NLR family, pyrin domain containing 3	Mus musculus	202-207
35035661-0	2022	Coenzyme Q0 Inhibits NLRP3 Inflammasome Activation through Mitophagy Induction in LPS/ATP-Stimulated Macrophages.	Adenosine Triphosphate	86-89	NLR family, pyrin domain containing 3	Mus musculus	21-26
35035661-9	2022	Interestingly, treatment with CoQ0 or Mito-TEMPO, but not NAC, significantly increased LPS/ATP-induced LC3-II accumulation indicating that mitophagy plays a key role in the regulation of CoQ0-inhibited NLRP3 inflammasome activation.	lc3-ii	103-109	NLR family, pyrin domain containing 3	Mus musculus	202-207
35035661-3	2022	CoQ0"s non- or subcytotoxic concentration suppressed the NLRP3 inflammasome and procaspase-1 activation, followed by downregulation of IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages.	ubiquinone-O	0-4	NLR family, pyrin domain containing 3	Mus musculus	57-62
35035661-10	2022	Nrf2 knockdown significantly decreased IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages suggesting that CoQ0 inhibited ROS-mediated NLRP3 inflammasome activation and IL1beta expression was suppressed due to the Nrf2 activation.	ubiquinone-O	117-121	NLR family, pyrin domain containing 3	Mus musculus	145-150
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	Adenosine Triphosphate	18-21	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-10	2022	Nrf2 knockdown significantly decreased IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages suggesting that CoQ0 inhibited ROS-mediated NLRP3 inflammasome activation and IL1beta expression was suppressed due to the Nrf2 activation.	ros	132-135	NLR family, pyrin domain containing 3	Mus musculus	145-150
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	ubiquinone-O	72-76	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	MitoTEMPO	78-88	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	Acetylcysteine	125-141	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	Acetylcysteine	143-146	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	ros	150-153	NLR family, pyrin domain containing 3	Mus musculus	222-227
34965184-10	2022	Lastly, the protective effects of S14G-HNG against MSU crystals-induced NLRP3 inflammasome activation were significantly abolished by the knockdown of SIRT1.	Uric Acid	51-54	NLR family, pyrin domain containing 3	Mus musculus	72-77
34988776-0	2022	Activation of alpha-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	Acetylcholine	32-45	NLR family, pyrin domain containing 3	Mus musculus	95-100
35035656-11	2022	Collectively, our findings confirmed that CAL alleviates DOX-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation in vivo and in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	42-45	NLR family, pyrin domain containing 3	Mus musculus	113-118
35035656-11	2022	Collectively, our findings confirmed that CAL alleviates DOX-induced cardiotoxicity and pyroptosis by inhibiting NLRP3 inflammasome activation in vivo and in vitro.	Doxorubicin	57-60	NLR family, pyrin domain containing 3	Mus musculus	113-118
34978026-5	2022	The results showed that CUMS caused a decrease in sucrose preference and an increase in immobility time, which were reversed by NLRP3 inhibitor MCC950.	Sucrose	50-57	NLR family, pyrin domain containing 3	Mus musculus	128-133
35282107-0	2022	The anti-inflammatory effects of cinnamyl alcohol on sepsis-induced mice via the NLRP3 inflammasome pathway.	cinnamyl alcohol	33-49	NLR family, pyrin domain containing 3	Mus musculus	81-86
35282107-12	2022	Western blot analysis and quantitative polymerase chain reaction (qPCR) demonstrated that cinnamyl alcohol decreased the expression of apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), nucleotide-binding oligomerization domain-like receptor 3 (NLRP3), and caspase-1 in the liver, heart, lungs, and kidneys of the mice, suggesting that cinnamyl alcohol alleviated sepsis syndrome via the NLRP3 inflammasome pathway.	cinnamyl alcohol	90-106	NLR family, pyrin domain containing 3	Mus musculus	233-290
35282107-12	2022	Western blot analysis and quantitative polymerase chain reaction (qPCR) demonstrated that cinnamyl alcohol decreased the expression of apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), nucleotide-binding oligomerization domain-like receptor 3 (NLRP3), and caspase-1 in the liver, heart, lungs, and kidneys of the mice, suggesting that cinnamyl alcohol alleviated sepsis syndrome via the NLRP3 inflammasome pathway.	cinnamyl alcohol	90-106	NLR family, pyrin domain containing 3	Mus musculus	292-297
35282107-12	2022	Western blot analysis and quantitative polymerase chain reaction (qPCR) demonstrated that cinnamyl alcohol decreased the expression of apoptosis-associated speck-like protein containing a C-terminal caspase recruitment domain (ASC), nucleotide-binding oligomerization domain-like receptor 3 (NLRP3), and caspase-1 in the liver, heart, lungs, and kidneys of the mice, suggesting that cinnamyl alcohol alleviated sepsis syndrome via the NLRP3 inflammasome pathway.	cinnamyl alcohol	90-106	NLR family, pyrin domain containing 3	Mus musculus	435-440
35083298-0	2021	Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy.	dapagliflozin	45-58	NLR family, pyrin domain containing 3	Mus musculus	121-126
35083298-15	2021	High-dose dapagliflozin pretreatment might limit NLRP3 inflammasome activation and mediate its selective autophagy.	dapagliflozin	10-23	NLR family, pyrin domain containing 3	Mus musculus	49-54
35006270-8	2022	Epac1 and forskolin both reduced Nek7 and NLRP3 pathway proteins, even when given in combination with Nek7 cDNA.	Colforsin	10-19	NLR family, pyrin domain containing 3	Mus musculus	42-47
35006270-12	2022	These studies establish that cAMP proteins can inhibit Nek7 and block activation of the NLRP3 inflammasome proteins.	Cyclic AMP	29-33	NLR family, pyrin domain containing 3	Mus musculus	88-93
34873072-0	2022	Oleanolic Acid Provides Neuroprotection against Ischemic Stroke through the Inhibition of Microglial Activation and NLRP3 Inflammasome Activation.	Oleanolic Acid	0-14	NLR family, pyrin domain containing 3	Mus musculus	116-121
35002527-4	2022	Wild-type (WT) and Nlrp3 knockout (KO) C57 mice were used to establish a type I diabetes model by intraperitoneal injection of streptozotocin.	Streptozocin	127-141	NLR family, pyrin domain containing 3	Mus musculus	19-24
35129032-0	2022	Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice.	ros	29-32	NLR family, pyrin domain containing 3	Mus musculus	33-38
35129032-2	2022	NLRP3 inflammasome and mitochondrial ROS (mtROS) have been implicated in ALI but its role in injury caused through two hit i.e. Hydrochloric acid (HCl) + Lipopolysaccharide (LPS) is not known.	Hydrochloric Acid	128-145	NLR family, pyrin domain containing 3	Mus musculus	0-5
35129032-2	2022	NLRP3 inflammasome and mitochondrial ROS (mtROS) have been implicated in ALI but its role in injury caused through two hit i.e. Hydrochloric acid (HCl) + Lipopolysaccharide (LPS) is not known.	Hydrochloric Acid	147-150	NLR family, pyrin domain containing 3	Mus musculus	0-5
34918381-7	2022	We further demonstrated that the immunomodulatory metabolite itaconate derived from the TCA cycle was significantly boosted as a result of decreased isocitrate dehydrogenase 2 and increased immune-responsive gene 1 and mitochondrial citrate carrier in dapagliflozin-treated mice, which contributed to the inhibitory effect of dapagliflozin on NLRP3 inflammasome activation.	itaconic acid	61-70	NLR family, pyrin domain containing 3	Mus musculus	343-348
34918381-8	2022	Furthermore, administration of cell-permeable itaconate surrogate prevented activation of NLRP3 inflammasome and protected kidney against fibrosis development.	itaconic acid	46-55	NLR family, pyrin domain containing 3	Mus musculus	90-95
35187972-0	2022	Inhibition of SET domain-containing (lysine methyltransferase) 7 alleviates cognitive impairment through suppressing the activation of NOD-like receptor protein 3 inflammasome in isoflurane-induced aged mice.	Isoflurane	179-189	NLR family, pyrin domain containing 3	Mus musculus	135-162
35187972-9	2022	CONCLUSION: Collectively, these results provided evidence that the inhibition of SETD7 could alleviate neuroinflammation, pyroptosis, and cognitive impairment by suppressing the activation of the NLRP3 inflammasome in isoflurane-induced aged mice.	Isoflurane	218-228	NLR family, pyrin domain containing 3	Mus musculus	196-201
35002527-11	2022	Mechanistically, the accumulated AGEs promoted hyperactivation of the NLRP3 inflammasome through ROS production.	ros	97-100	NLR family, pyrin domain containing 3	Mus musculus	70-75
35212223-9	2022	When Tlr4 was knocked in LPS/ATP-stimulated BMDMs, HMGB1 production and release were blocked, and NLRP3-mediated cleavage and release of IL-1beta was suppressed in Hmgb1-silenced BMDMs.	Adenosine Triphosphate	29-32	NLR family, pyrin domain containing 3	Mus musculus	98-103
35378138-10	2022	The UUO induced expressions of nod-like receptor protein 3 (NLRP3), active caspase 1, interleukin(IL)-18, and IL-1beta proteins were decreased in the BCA treated groups.	biochanin A	150-153	NLR family, pyrin domain containing 3	Mus musculus	31-58
35378138-10	2022	The UUO induced expressions of nod-like receptor protein 3 (NLRP3), active caspase 1, interleukin(IL)-18, and IL-1beta proteins were decreased in the BCA treated groups.	biochanin A	150-153	NLR family, pyrin domain containing 3	Mus musculus	60-65