PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33621883-5	2021	Low concentrations of BPAF markedly increased the expression of G protein-coupled estrogen receptor (GPER1), c-Myc, CyclinD1 and c-Fos proteins, and enhanced phosphorylation of extracellular signal-regulated kinase (Erk) and protein kinase B (Akt) in SKBR-3 cells.	4,4'-hexafluorisopropylidene diphenol	22-26	G protein-coupled estrogen receptor 1	Homo sapiens	101-106
33848615-5	2021	In this study, MTT, Western blot, immunocytochemical staining, phagocytosis assay and wound healing assay were employed to detect the effect of GPR30 in N9 microglial cells after exposure to glutamate.	Glutamic Acid	191-200	G protein-coupled estrogen receptor 1	Homo sapiens	144-149
33848615-6	2021	We found that the treatment of GPR30 specific agonist G1 inhibited glutamate-induced proliferation and activation in N9 microglial cells.	Glutamic Acid	67-76	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
33621883-9	2021	The findings showed that GPER1 could independently regulate BPAF-induced proliferation of SKBR-3 cells without requiring ERalpha.	4,4'-hexafluorisopropylidene diphenol	60-64	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
34021926-10	2021	Conversely, GPER1 antagonist G15 reversed all these features induced by estrogen.	CHEMBL583543	29-32	G protein-coupled estrogen receptor 1	Homo sapiens	12-17
33868470-0	2021	Activation of GPER by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway.	Estradiol	22-24	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
33868470-10	2021	The results demonstrated that E2 downregulated miR-124 expression, while upregulating G protein -coupled estrogen receptor (GPER) expression in MCF-7 cells.	Estradiol	30-32	G protein-coupled estrogen receptor 1	Homo sapiens	86-122
33868470-10	2021	The results demonstrated that E2 downregulated miR-124 expression, while upregulating G protein -coupled estrogen receptor (GPER) expression in MCF-7 cells.	Estradiol	30-32	G protein-coupled estrogen receptor 1	Homo sapiens	124-128
33868470-11	2021	Following treatment with the GPER antagonist, G15, miR-124 expression was significantly enhanced and E2-induced proliferation, invasion and migration of MCF-7 cells were notably inhibited.	Estradiol	101-103	G protein-coupled estrogen receptor 1	Homo sapiens	29-33
33868470-14	2021	Taken together, these results suggest that upregulation of GPER expression induced by E2 promotes proliferation, invasion and migration of breast cancer cells by regulating the miR-124/CD151 pathway.	Estradiol	86-88	G protein-coupled estrogen receptor 1	Homo sapiens	59-63
34032001-11	2021	Combined with the bioinformatics analysis, XBP-1, IRF-4 and GPER-1 expression was related to E2 levels, both in vivo and in vitro.	Estradiol	93-95	G protein-coupled estrogen receptor 1	Homo sapiens	60-66
33893075-3	2021	MATERIALS AND METHODS: Parental and sunitinib-resistant 786-O cells were treated with GPER1 agonist G-1, and quantitative phosphoproteomics was performed.	Sunitinib	36-45	G protein-coupled estrogen receptor 1	Homo sapiens	86-91
33938030-9	2021	Our results pinpoint the function of GPR30 in prostate CAFs on regulating the CAF-TAM interaction in the TME and provide new insights into PCa therapies via regulating TME.	tam	82-85	G protein-coupled estrogen receptor 1	Homo sapiens	37-42
33893075-8	2021	CONCLUSION: Our results open up the possibility for managing RCC and sunitinib resistance by GPER1 agonist G-1 and its regulated pathways.	Sunitinib	69-78	G protein-coupled estrogen receptor 1	Homo sapiens	93-98
33879537-10	2021	Altogether, the findings suggest that E2 activates ERbeta and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking.Significance StatementSusceptibility to drug craving and relapse is heightened in women with cocaine use disorder and varies across the reproductive cycle, likely reflecting the influence of the estrogen, 17beta-estradiol.	Estradiol	38-40	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
33923905-7	2021	The classic ERs have been acknowledged to function in mediating estrogen effects on glucose metabolism, but 17beta-estradiol also rapidly promotes endothelial glycolysis by increasing glucose transporter 1 (GLUT1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) levels through GPER-dependent mechanisms.	Estradiol	108-124	G protein-coupled estrogen receptor 1	Homo sapiens	296-300
33582643-0	2021	Insight into the mechanism of tetrachlorobisphenol A (TCBPA)-induced proliferation of breast cancer cells by GPER-mediated signaling pathways.	tetrachlorodian	30-52	G protein-coupled estrogen receptor 1	Homo sapiens	109-113
33582643-0	2021	Insight into the mechanism of tetrachlorobisphenol A (TCBPA)-induced proliferation of breast cancer cells by GPER-mediated signaling pathways.	tetrachlorodian	54-59	G protein-coupled estrogen receptor 1	Homo sapiens	109-113
33582643-2	2021	However, there is only limited data on the mechanisms through which TCBPA-associated estrogenic activity is related to the membrane G protein-coupled estrogen receptor (GPER) pathway.	tetrachlorodian	68-73	G protein-coupled estrogen receptor 1	Homo sapiens	132-167
33582643-2	2021	However, there is only limited data on the mechanisms through which TCBPA-associated estrogenic activity is related to the membrane G protein-coupled estrogen receptor (GPER) pathway.	tetrachlorodian	68-73	G protein-coupled estrogen receptor 1	Homo sapiens	169-173
33582643-4	2021	The role of GPER signaling in TCBPA-induced cell proliferation was studied by analyzing the protein expression and mRNA levels of relevant signal targets.	tetrachlorodian	30-35	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
33582643-6	2021	Low-concentration TCBPA also upregulated the expression of GPER, CyclinD1, c-Myc, and c-Fos proteins, as well as increased the phosphorylation of extracellular signal-regulated-kinase 1/2 (Erk1/2) and protein kinase B (Akt).	tetrachlorodian	18-23	G protein-coupled estrogen receptor 1	Homo sapiens	59-63
33582643-8	2021	However, the phosphorylation of Erk1/2 and Akt decreased when the cells were treated with GPER inhibitor G15 and phosphatidylinositide 3-kinase (PI3K) inhibitor wortmannin (WM) prior to TCBPA exposure.	tetrachlorodian	186-191	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
33582643-10	2021	In ERalpha-positive MCF-7 cells, TCBPA also upregulated ERalpha expression, and ERalpha was found to interact with GPER-mediated signaling.	tetrachlorodian	33-38	G protein-coupled estrogen receptor 1	Homo sapiens	115-119
33582643-11	2021	The results indicate that GPER activates the PI3K/Akt and Erk1/2 signal cascades to drive the cell proliferation observed for low concentrations of TCBPA.	tetrachlorodian	148-153	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
33582643-12	2021	The presented results suggest a new mechanism by which TCBPA exerts estrogenic action in breast cancer cells, namely, GPER signaling in an ERalpha-independent manner, and also highlights the potential risks to human health of the usage of TCBPA.	tetrachlorodian	55-60	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
33582643-12	2021	The presented results suggest a new mechanism by which TCBPA exerts estrogenic action in breast cancer cells, namely, GPER signaling in an ERalpha-independent manner, and also highlights the potential risks to human health of the usage of TCBPA.	tetrachlorodian	239-244	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
33879537-10	2021	Altogether, the findings suggest that E2 activates ERbeta and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking.Significance StatementSusceptibility to drug craving and relapse is heightened in women with cocaine use disorder and varies across the reproductive cycle, likely reflecting the influence of the estrogen, 17beta-estradiol.	gamma-Aminobutyric Acid	100-104	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
33879537-10	2021	Altogether, the findings suggest that E2 activates ERbeta and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking.Significance StatementSusceptibility to drug craving and relapse is heightened in women with cocaine use disorder and varies across the reproductive cycle, likely reflecting the influence of the estrogen, 17beta-estradiol.	Cocaine	153-160	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
33915037-0	2021	Eplerenone inhibits oxidized low-density lipoprotein-induced proliferation and migration of vascular smooth muscle cells by downregulating GPER expression.	Eplerenone	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	139-143
33915037-13	2021	CONCLUSIONS: Eplerenone suppressed ox-LDL-induced proliferation and migration of VSMCs partly through downregulation of GPER, providing a new mechanism of support for EPL use in the clinical treatment of AS.	Eplerenone	13-23	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
32971159-0	2021	Formononetin attenuates atopic dermatitis by upregulating A20 expression via activation of G protein-coupled estrogen receptor.	formononetin	0-12	G protein-coupled estrogen receptor 1	Homo sapiens	91-126
33460806-3	2021	In this study, the molecular mechanism of fluoxetine-induced the proliferation of breast cancer SKBR3 and MCF-7 cells was evaluated by detecting ERalpha and GPR30-mediated ERK and PI3K/AKT signals.	Fluoxetine	42-52	G protein-coupled estrogen receptor 1	Homo sapiens	157-162
33460806-4	2021	We found that low concentrations of fluoxetine upregulated the expression of GPR30, ERalpha, CyclinD1, and C-MYC proteins, as well as elevated the phosphorylation of ERK and AKT.	Fluoxetine	36-46	G protein-coupled estrogen receptor 1	Homo sapiens	77-82
33460806-5	2021	The phosphorylation of ERK and AKT decreased when the cells were pretreated with ERalpha inhibitor ICI, GPR30 inhibitor G15, and PI3K inhibitor WM prior to fluoxetine exposure.	Fluoxetine	156-166	G protein-coupled estrogen receptor 1	Homo sapiens	104-109
33460806-7	2021	These findings indicated that fluoxetine activated the PI3K/AKT and ERK signaling cascades via GPR30 to derive the cell proliferation.	Fluoxetine	30-40	G protein-coupled estrogen receptor 1	Homo sapiens	95-100
33460806-8	2021	It suggests that fluoxetine has the potential to exert estrogen actions via GPR30.	Fluoxetine	17-27	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
33508329-9	2021	Moreover, E2 and E2-BSA induced cAMP production in the in vitro incubated follicles at mid-vitellogenic stage but not the GVBD stage, and the induction could be completely abolished by G-15, a Gper1 inhibitor.	Cyclic AMP	32-36	G protein-coupled estrogen receptor 1	Homo sapiens	193-198
33795755-8	2021	G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER.	Zearalenone	84-87	G protein-coupled estrogen receptor 1	Homo sapiens	0-39
33795755-8	2021	G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER.	Zearalenone	84-87	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
33795755-8	2021	G protein-coupled estrogenic receptor 1 (GPER) protein expression was promoted upon ZEA treatment suggesting the involvement of GPER.	Zearalenone	84-87	G protein-coupled estrogen receptor 1	Homo sapiens	128-132
33629579-7	2021	However, knockdown of GPR30 by shRNA significantly counteracted the cardioprotective effect of DEX.	Dexmedetomidine	95-98	G protein-coupled estrogen receptor 1	Homo sapiens	22-27
33739385-5	2022	Sex steroids such as androgens, progestins, and estrogen and their receptors (ERalpha, ERbeta, GPER; PR-A, PR-B; AR) have been identified as important modifiers of angiogenesis, and sex differences have been reported for anti-angiogenic drugs.	Steroids	4-12	G protein-coupled estrogen receptor 1	Homo sapiens	95-99
33314369-0	2021	Downregulated GPR30 Expression in the Epileptogenic Foci of Female Patients with Focal Cortical Dysplasia Type IIb and Tuberous Sclerosis Complex Is Correlated with 18 F-FDG PET-CT Values.	Fluorodeoxyglucose F18	165-173	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
33314369-3	2021	Therefore, we investigated the role of GPR30 in patients with FCDIIb and TSC.	fcdiib	62-68	G protein-coupled estrogen receptor 1	Homo sapiens	39-44
33314369-12	2021	Taken together, our results suggest a potential protective effect of GPR30 in the epileptogenesis of female patients with FCDIIb and TSC.	fcdiib	122-128	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
33574796-5	2020	In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30.	Estradiol	35-51	G protein-coupled estrogen receptor 1	Homo sapiens	320-324
33069770-6	2021	Functionally, GPER1 activation inhibits 17beta-oestradiol (E2)-induced ER + breast cancer cell proliferation, migration, and invasion in vitro and tumour growth in vivo.	Estradiol	40-57	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
33069770-6	2021	Functionally, GPER1 activation inhibits 17beta-oestradiol (E2)-induced ER + breast cancer cell proliferation, migration, and invasion in vitro and tumour growth in vivo.	Estradiol	59-61	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
33574796-5	2020	In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30.	Estradiol	35-51	G protein-coupled estrogen receptor 1	Homo sapiens	325-330
33574796-5	2020	In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30.	Estradiol	53-55	G protein-coupled estrogen receptor 1	Homo sapiens	320-324
33574796-5	2020	In human seminoma cell line, while 17beta-estradiol (E2) inhibits in vitro cell proliferation through an ERbeta-dependent mechanism, an impermeable E2 conjugate (E2 coupled to BSA), in vitro cell proliferation is stimulated by activating ERK1/2 and protein kinase A through a membrane GPCR that we further identified as GPER/GPR30.	Estradiol	53-55	G protein-coupled estrogen receptor 1	Homo sapiens	325-330
33039870-0	2021	Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN.	bis(4-hydroxyphenyl)sulfone	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
33039870-0	2021	Bisphenol A induces apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK pathway in human granulosa cell line KGN.	Reactive Oxygen Species	71-74	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
33039870-9	2021	We pretreated with G15 (a GPER inhibitor) and found that BPA-induced ROS generation and Ca2+ accumulation and apoptosis were significantly inhibited.	bisphenol A	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
33039870-9	2021	We pretreated with G15 (a GPER inhibitor) and found that BPA-induced ROS generation and Ca2+ accumulation and apoptosis were significantly inhibited.	Reactive Oxygen Species	69-72	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
33039870-10	2021	These results suggest that BPA exposure induces KGN cell apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK signaling pathway.	bisphenol A	27-30	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
33039870-10	2021	These results suggest that BPA exposure induces KGN cell apoptosis through GPER-dependent activation of the ROS/Ca2+-ASK1-JNK signaling pathway.	Reactive Oxygen Species	108-111	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
33435260-0	2021	Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells.	1,2,3,4-tetrahydroquinoline	21-40	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
33435260-0	2021	Modifications on the Tetrahydroquinoline Scaffold Targeting a Phenylalanine Cluster on GPER as Antiproliferative Compounds against Renal, Liver and Pancreatic Cancer Cells.	Phenylalanine	62-75	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
33435260-2	2021	In this study, three new compounds were designed and synthesized with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-tox) properties and high affinity for the G protein-coupled estrogen receptor (GPER) binding site by in silico methods, which correlated with the growth inhibitory activity tested in a cluster of cancer cell lines.	adme	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	188-223
33435260-2	2021	In this study, three new compounds were designed and synthesized with suitable absorption, distribution, metabolism, excretion and toxicity (ADME-tox) properties and high affinity for the G protein-coupled estrogen receptor (GPER) binding site by in silico methods, which correlated with the growth inhibitory activity tested in a cluster of cancer cell lines.	adme	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	225-229
33435260-4	2021	These in silico studies showed that the compounds reached the GPER binding site, establishing interactions with a phenylalanine cluster (F206, F208 and F278) required for GPER molecular recognition of its agonist and antagonist ligands.	Phenylalanine	114-127	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
33435260-4	2021	These in silico studies showed that the compounds reached the GPER binding site, establishing interactions with a phenylalanine cluster (F206, F208 and F278) required for GPER molecular recognition of its agonist and antagonist ligands.	Phenylalanine	114-127	G protein-coupled estrogen receptor 1	Homo sapiens	171-175
33035625-0	2021	Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	80-84	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
32985706-7	2021	NDV-D90 promoted apoptosis via the intrinsic signaling pathway in BT549 cells (ER-negative cells), possibly by impairing E2-mediated GPER expression.	Estradiol	121-123	G protein-coupled estrogen receptor 1	Homo sapiens	133-137
33022573-12	2021	Further results showed that BPA upregulated WDR5 expression through the G protein-coupled estrogen receptor (GPER)-mediated PI3K/mTOR signaling pathway.	bisphenol A	28-31	G protein-coupled estrogen receptor 1	Homo sapiens	72-107
33022573-12	2021	Further results showed that BPA upregulated WDR5 expression through the G protein-coupled estrogen receptor (GPER)-mediated PI3K/mTOR signaling pathway.	bisphenol A	28-31	G protein-coupled estrogen receptor 1	Homo sapiens	109-113
33035625-0	2021	Anti-inflammatory effect of IGF-1 is mediated by IGF-1R cross talk with GPER in MPTP/MPP+-induced astrocyte activation.	mangion-purified polysaccharide (Candida albicans)	85-89	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
33035625-5	2021	The IGF-1R antagonist JB-1 and the GPER antagonist G15 could antagonize the anti-inflammatory effect of IGF-1.	CHEMBL583543	51-54	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
33035625-6	2021	Silencing GPER abrogated the inhibitory effect of IGF-1 on 1-methyl-4-phenylpyridinium (MPP+)-induced upregulation of COX-2 and iNOS in primary astrocytes.	1-Methyl-4-phenylpyridinium	59-86	G protein-coupled estrogen receptor 1	Homo sapiens	10-14
33035625-6	2021	Silencing GPER abrogated the inhibitory effect of IGF-1 on 1-methyl-4-phenylpyridinium (MPP+)-induced upregulation of COX-2 and iNOS in primary astrocytes.	mangion-purified polysaccharide (Candida albicans)	88-92	G protein-coupled estrogen receptor 1	Homo sapiens	10-14
33035625-10	2021	Furthermore, IGF-1 treatment alone increased the expression of GPER, which was blocked by JB-1, the phosphatidylinositol 3-kinase (PI3-K) antagonist LY294002 and the MEK antagonist PD98059 in primary astrocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	149-157	G protein-coupled estrogen receptor 1	Homo sapiens	63-67
33035625-10	2021	Furthermore, IGF-1 treatment alone increased the expression of GPER, which was blocked by JB-1, the phosphatidylinositol 3-kinase (PI3-K) antagonist LY294002 and the MEK antagonist PD98059 in primary astrocytes.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	181-188	G protein-coupled estrogen receptor 1	Homo sapiens	63-67
33035625-11	2021	Overall, we show for the first time that GPER may contribute to the anti-inflammatory effect of IGF-1 against MPTP/MPP + -induced astrocyte activation.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	110-114	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
33035625-11	2021	Overall, we show for the first time that GPER may contribute to the anti-inflammatory effect of IGF-1 against MPTP/MPP + -induced astrocyte activation.	mangion-purified polysaccharide (Candida albicans)	115-120	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
33068422-2	2020	Here, we observed that both estradiol and the GPER-specific agonist G1 rapidly induced cAMP production in cumulus cells, leading to transient stimulation of phosphorylated cAMP response element binding protein (CREB), which was conducive to the transcription of epidermal growth factor (EGF)-like factors, amphiregulin, epiregulin, and betacellulin.	Cyclic AMP	87-91	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
33425895-6	2020	Moreover, 740Y-P, a PI3K activator, reversed the effects of GPER1 knockdown on EMT processes.	740y-p	10-16	G protein-coupled estrogen receptor 1	Homo sapiens	60-65
33068422-3	2020	Inhibition of GPER by G15 significantly reduced estradiol-induced CREB phosphorylation and EGF-like factor gene expression.	Estradiol	48-57	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
33068422-0	2020	Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor.	Estradiol	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	85-120
33068422-4	2020	Consistently, the silencing of GPER expression in cultured cumulus cells abrogated the estradiol-induced CREB phosphorylation and EGF-like factor transcription.	Estradiol	87-96	G protein-coupled estrogen receptor 1	Homo sapiens	31-35
33299978-3	2020	We found that the G-protein-coupled estrogen receptor (GPER) heteromerizes with FSHR, reprogramming cAMP/death signals into proliferative stimuli fundamental for sustaining oocyte survival.	Cyclic AMP	100-104	G protein-coupled estrogen receptor 1	Homo sapiens	18-53
33299978-3	2020	We found that the G-protein-coupled estrogen receptor (GPER) heteromerizes with FSHR, reprogramming cAMP/death signals into proliferative stimuli fundamental for sustaining oocyte survival.	Cyclic AMP	100-104	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
33299978-4	2020	In human granulosa cells, survival signals are missing at high FSHR:GPER ratio, which negatively impacts follicle maturation and strongly correlates with preferential Galphas protein/cAMP-pathway coupling and FSH responsiveness of patients undergoing controlled ovarian stimulation.	Cyclic AMP	183-187	G protein-coupled estrogen receptor 1	Homo sapiens	68-72
33193095-2	2020	We recently reported that acute application of E2 at the onset of reperfusion in vivo induces cardioprotective effects against I/R injury via activation of its non-steroidal receptor, G protein-coupled estrogen receptor 1 (GPER1).	Estradiol	47-49	G protein-coupled estrogen receptor 1	Homo sapiens	184-221
33193108-6	2020	In the non-genomic pathway, 17beta-estradiol binds a putative plasma membrane ER (mER) such as GPR30/GPER1 to rapidly signal via kinases or calcium flux.	Estradiol	28-44	G protein-coupled estrogen receptor 1	Homo sapiens	95-100
33193108-6	2020	In the non-genomic pathway, 17beta-estradiol binds a putative plasma membrane ER (mER) such as GPR30/GPER1 to rapidly signal via kinases or calcium flux.	Estradiol	28-44	G protein-coupled estrogen receptor 1	Homo sapiens	101-106
33193108-6	2020	In the non-genomic pathway, 17beta-estradiol binds a putative plasma membrane ER (mER) such as GPR30/GPER1 to rapidly signal via kinases or calcium flux.	Calcium	140-147	G protein-coupled estrogen receptor 1	Homo sapiens	95-100
33193108-6	2020	In the non-genomic pathway, 17beta-estradiol binds a putative plasma membrane ER (mER) such as GPR30/GPER1 to rapidly signal via kinases or calcium flux.	Calcium	140-147	G protein-coupled estrogen receptor 1	Homo sapiens	101-106
33091936-9	2021	GPER1 expression was detected in 62.2% of the GH-secreting adenomas and 45% of NFAs.	Niflumic Acid	79-83	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
33091936-13	2021	CONCLUSIONS: GPER1 is expressed at both gene and protein level in a substantial portion of GH-secreting adenomas and NFAs.	Niflumic Acid	117-121	G protein-coupled estrogen receptor 1	Homo sapiens	13-18
33193095-2	2020	We recently reported that acute application of E2 at the onset of reperfusion in vivo induces cardioprotective effects against I/R injury via activation of its non-steroidal receptor, G protein-coupled estrogen receptor 1 (GPER1).	Estradiol	47-49	G protein-coupled estrogen receptor 1	Homo sapiens	223-228
33066495-4	2020	Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	227-256
33066495-4	2020	Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	258-263
33066495-4	2020	Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma.	bisphenol A	13-16	G protein-coupled estrogen receptor 1	Homo sapiens	227-256
33066495-4	2020	Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERalpha and ERbeta), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma.	bisphenol A	13-16	G protein-coupled estrogen receptor 1	Homo sapiens	258-263
33066495-6	2020	Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators.	bisphenol A	132-135	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
32628929-0	2020	beta-estradiol adjusts intestinal function via ERbeta and GPR30 mediated PI3K/AKT signaling activation to alleviate postmenopausal dyslipidemia.	Estradiol	0-14	G protein-coupled estrogen receptor 1	Homo sapiens	58-63
32865008-9	2020	These data suggest that IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3k-Akt-mTOR pathway and GPER.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	39-43	G protein-coupled estrogen receptor 1	Homo sapiens	136-140
32827762-7	2020	Treatment with G15, a G-protein coupled estrogen receptor 1 antagonist, abolishes the effect of increased sphingolipid and non-sphingolipid levels in SKBr3 cells.	Sphingolipids	106-118	G protein-coupled estrogen receptor 1	Homo sapiens	22-59
32628929-8	2020	ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol.	Estradiol	62-76	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32628929-8	2020	ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol.	Cholesterol	80-91	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32628929-8	2020	ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol.	Cholesterol	143-154	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32628929-8	2020	ERbeta or GPR30 inhibition decreased the protective effect of beta-estradiol on cholesterol accumulation, tight junctions, and inflammation in cholesterol incubated Caco-2 cells, while silencing both ERbeta and GPR30 completely eliminated the protective effect of beta-estradiol.	Estradiol	264-278	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32628929-10	2020	Our results provide evidence that beta-estradiol regulates intestinal function via ERbeta and GPR30 mediated PI3K/AKT signaling activation to alleviate postmenopausal dyslipidemia.	Estradiol	34-48	G protein-coupled estrogen receptor 1	Homo sapiens	94-99
32827762-7	2020	Treatment with G15, a G-protein coupled estrogen receptor 1 antagonist, abolishes the effect of increased sphingolipid and non-sphingolipid levels in SKBr3 cells.	Sphingolipids	127-139	G protein-coupled estrogen receptor 1	Homo sapiens	22-59
33117280-0	2020	Continuous Exposure of Breast Cancer Cells to Tamoxifen Upregulates GPER-1 and Increases Cell Proliferation.	Tamoxifen	46-55	G protein-coupled estrogen receptor 1	Homo sapiens	68-74
32513838-2	2020	Estradiol-induced cellular changes are mediated through the activation of nuclear and extranuclear estrogen receptors (ERs), which include ERalpha, ERbeta, and the G-protein coupled receptor, GPER1.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
33117280-3	2020	Moreover, absence of GPER-1 improves the prognosis of patients treated with tamoxifen, the most used selective estrogen receptor modulator to treat ERalpha-positive breast cancer.	Tamoxifen	76-85	G protein-coupled estrogen receptor 1	Homo sapiens	21-27
33117280-4	2020	MCF-7 breast cancer cells were continuously treated with 1,000 nM tamoxifen for 7 days to investigate its effect on GPER-1 protein expression, cell proliferation and intracellular [Ca2+]i mobilization, a key signaling pathway.	Tamoxifen	66-75	G protein-coupled estrogen receptor 1	Homo sapiens	116-122
33117280-5	2020	Breast cancer cells continuously treated with tamoxifen, exhibited a robust [Ca2+]i mobilization after stimulation with 1,000 nM tamoxifen, a response that was blunted by preincubation of cells with G15, a commercial GPER-1 antagonist.	Tamoxifen	46-55	G protein-coupled estrogen receptor 1	Homo sapiens	217-223
33117280-5	2020	Breast cancer cells continuously treated with tamoxifen, exhibited a robust [Ca2+]i mobilization after stimulation with 1,000 nM tamoxifen, a response that was blunted by preincubation of cells with G15, a commercial GPER-1 antagonist.	Tamoxifen	129-138	G protein-coupled estrogen receptor 1	Homo sapiens	217-223
33117280-7	2020	Proliferation of cells continuously treated with tamoxifen and stimulated with 2,000 nM tamoxifen, was also higher than that observed in untreated cells in a degree that was approximately 90% attributable to GPER-1.	Tamoxifen	49-58	G protein-coupled estrogen receptor 1	Homo sapiens	208-214
33117280-7	2020	Proliferation of cells continuously treated with tamoxifen and stimulated with 2,000 nM tamoxifen, was also higher than that observed in untreated cells in a degree that was approximately 90% attributable to GPER-1.	Tamoxifen	88-97	G protein-coupled estrogen receptor 1	Homo sapiens	208-214
33117280-9	2020	Although we cannot fully extrapolate the results obtained in vitro to the patients, our results shed some light on the occurrence of drug resistance in breast cancer patients who are ERalpha/GPER-1 positive, have been treated with tamoxifen and display low survival rate.	Tamoxifen	231-240	G protein-coupled estrogen receptor 1	Homo sapiens	191-197
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	Cyclic AMP	43-47	G protein-coupled estrogen receptor 1	Homo sapiens	29-33
33133016-2	2020	Via three receptors known to date, including estrogen receptors alpha (ERalpha) and beta (ERbeta) and the G protein-coupled estrogen receptor 1 (GPER, aka GPR30), E2 regulates numerous calcium-dependent activities in cardiovascular tissues.	Calcium	185-192	G protein-coupled estrogen receptor 1	Homo sapiens	106-143
33133016-2	2020	Via three receptors known to date, including estrogen receptors alpha (ERalpha) and beta (ERbeta) and the G protein-coupled estrogen receptor 1 (GPER, aka GPR30), E2 regulates numerous calcium-dependent activities in cardiovascular tissues.	Calcium	185-192	G protein-coupled estrogen receptor 1	Homo sapiens	145-149
33133016-2	2020	Via three receptors known to date, including estrogen receptors alpha (ERalpha) and beta (ERbeta) and the G protein-coupled estrogen receptor 1 (GPER, aka GPR30), E2 regulates numerous calcium-dependent activities in cardiovascular tissues.	Calcium	185-192	G protein-coupled estrogen receptor 1	Homo sapiens	155-160
32978426-2	2020	Our previous work in activated human peripheral blood mononuclear cells demonstrated that exposure to "low-dose" BPA diminished telomerase activity via an ER/GPR30-ERK signalling pathway.	bisphenol A	113-116	G protein-coupled estrogen receptor 1	Homo sapiens	158-163
32957524-2	2020	Fifteen years ago, it was discovered that a member of the G protein-coupled receptor family, GPR30, which binds also with high affinity to estradiol and is responsible, in part, for the rapid non-genomic actions of estrogens.	Estradiol	139-148	G protein-coupled estrogen receptor 1	Homo sapiens	93-98
32906618-5	2020	The estrogen-agonistic effect of tamoxifen in endometrial cancers can also be explained by the expression of G-protein coupled estrogen receptor 1 (GPER-1), a membrane-bound estrogen receptor for which tamoxifen and other "antiestrogens" are pure agonists.	Tamoxifen	33-42	G protein-coupled estrogen receptor 1	Homo sapiens	109-146
32906618-5	2020	The estrogen-agonistic effect of tamoxifen in endometrial cancers can also be explained by the expression of G-protein coupled estrogen receptor 1 (GPER-1), a membrane-bound estrogen receptor for which tamoxifen and other "antiestrogens" are pure agonists.	Tamoxifen	33-42	G protein-coupled estrogen receptor 1	Homo sapiens	148-154
32906618-5	2020	The estrogen-agonistic effect of tamoxifen in endometrial cancers can also be explained by the expression of G-protein coupled estrogen receptor 1 (GPER-1), a membrane-bound estrogen receptor for which tamoxifen and other "antiestrogens" are pure agonists.	Tamoxifen	202-211	G protein-coupled estrogen receptor 1	Homo sapiens	109-146
32906618-5	2020	The estrogen-agonistic effect of tamoxifen in endometrial cancers can also be explained by the expression of G-protein coupled estrogen receptor 1 (GPER-1), a membrane-bound estrogen receptor for which tamoxifen and other "antiestrogens" are pure agonists.	Tamoxifen	202-211	G protein-coupled estrogen receptor 1	Homo sapiens	148-154
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Steroids	38-45	G protein-coupled estrogen receptor 1	Homo sapiens	69-106
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Steroids	38-45	G protein-coupled estrogen receptor 1	Homo sapiens	108-113
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	G protein-coupled estrogen receptor 1	Homo sapiens	69-106
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	221-239	G protein-coupled estrogen receptor 1	Homo sapiens	108-113
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	G protein-coupled estrogen receptor 1	Homo sapiens	69-106
32907599-3	2020	Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects.	Ecdysterone	241-244	G protein-coupled estrogen receptor 1	Homo sapiens	108-113
33061416-8	2020	Moreover, the overexpression of ERRalpha induced by estrogen and G1 (GPER agonist) was reversed by knocking down of GPER and blocking the MAPK signaling with PD98059 in both cell lines.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	158-165	G protein-coupled estrogen receptor 1	Homo sapiens	69-73
32559878-0	2020	Tricresyl phosphate isomers exert estrogenic effects via G protein-coupled estrogen receptor-mediated pathways.	Tritolyl Phosphates	0-19	G protein-coupled estrogen receptor 1	Homo sapiens	57-92
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	tmcp	93-97	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	tmcp	93-97	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	tmcp	93-97	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	Calcium	160-167	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	Calcium	160-167	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-6	2020	Both ToCP and TpCP activated GPER-mediated cAMP production and calcium mobilization, whereas TmCP had different mode of action, it only triggered GPER-mediated calcium mobilization, as evidenced by using the specific GPER inhibitor (G15) and GPER overexpressing experiments.	Calcium	160-167	G protein-coupled estrogen receptor 1	Homo sapiens	146-150
32559878-8	2020	Our results, for the first time, found a new target, GPER, for TCPs exerting their estrogen-disrupting effects, and demonstrated complex estrogen-disrupting effects of three TCP isomers involved their opposite activities toward ERalpha and GPER.	Tritolyl Phosphates	63-66	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
32559878-8	2020	Our results, for the first time, found a new target, GPER, for TCPs exerting their estrogen-disrupting effects, and demonstrated complex estrogen-disrupting effects of three TCP isomers involved their opposite activities toward ERalpha and GPER.	Tritolyl Phosphates	63-66	G protein-coupled estrogen receptor 1	Homo sapiens	240-244
33084596-7	2020	Estradiol and GPER ligands provide a similar pattern of fit to adenine nucleotide.	Adenine Nucleotides	63-81	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
32757462-2	2020	We recently showed that 17beta-estradiol (E2) triggers angiogenesis via the membrane G-protein coupled estrogen receptor (GPER) and the key glycolytic protein PFKFB3 as a downstream effector.	Estradiol	24-40	G protein-coupled estrogen receptor 1	Homo sapiens	85-120
32757462-2	2020	We recently showed that 17beta-estradiol (E2) triggers angiogenesis via the membrane G-protein coupled estrogen receptor (GPER) and the key glycolytic protein PFKFB3 as a downstream effector.	Estradiol	24-40	G protein-coupled estrogen receptor 1	Homo sapiens	122-126
32757462-2	2020	We recently showed that 17beta-estradiol (E2) triggers angiogenesis via the membrane G-protein coupled estrogen receptor (GPER) and the key glycolytic protein PFKFB3 as a downstream effector.	Estradiol	42-44	G protein-coupled estrogen receptor 1	Homo sapiens	85-120
32757462-2	2020	We recently showed that 17beta-estradiol (E2) triggers angiogenesis via the membrane G-protein coupled estrogen receptor (GPER) and the key glycolytic protein PFKFB3 as a downstream effector.	Estradiol	42-44	G protein-coupled estrogen receptor 1	Homo sapiens	122-126
32757462-5	2020	In the presence of cycloheximide, E2 and G1 treatment counteracted PFKFB3 degradation over time, whereas E2-induced PFKFB3 stabilization was abolished by the GPER antagonist G15.	CHEMBL583543	174-177	G protein-coupled estrogen receptor 1	Homo sapiens	158-162
33070824-3	2020	RESULTS: The high concentration of genistein promoted the expression of ERbeta and GPR30 in the SW579 cells, but ERalpha was not expressed.	Genistein	35-44	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
32757462-10	2020	Finally, E2 and G1 treatments rapidly enhanced glucose transporter GLUT1 levels via GPER independent of transcriptional activation.	Glucose	47-54	G protein-coupled estrogen receptor 1	Homo sapiens	84-88
33070824-5	2020	CONCLUSION: Genistein can obiviously promote the cell proliferation in the SW579 cells, which may be related to the action of GPR30.	Genistein	12-21	G protein-coupled estrogen receptor 1	Homo sapiens	126-131
33070824-2	2020	METHODS: The real-time PCR was applied to detect the expression of estrogen receptor(ER)alpha ERbeta and G protein-coupled receptor(GPR)30 in human thyroid squamous cell line SW579; MTT was used to test the effect of genistein on cell proliferation in the SW579 cells before and after blocking GPR30; flow cytometry was explorited to measure the effect of genistein on the cell cycle and apoptosis in the SW579 was detected before and after blocking GPR30.	monooxyethylene trimethylolpropane tristearate	182-185	G protein-coupled estrogen receptor 1	Homo sapiens	294-299
33070824-2	2020	METHODS: The real-time PCR was applied to detect the expression of estrogen receptor(ER)alpha ERbeta and G protein-coupled receptor(GPR)30 in human thyroid squamous cell line SW579; MTT was used to test the effect of genistein on cell proliferation in the SW579 cells before and after blocking GPR30; flow cytometry was explorited to measure the effect of genistein on the cell cycle and apoptosis in the SW579 was detected before and after blocking GPR30.	monooxyethylene trimethylolpropane tristearate	182-185	G protein-coupled estrogen receptor 1	Homo sapiens	450-455
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Calcium	196-203	G protein-coupled estrogen receptor 1	Homo sapiens	13-48
32743632-3	2020	Among these techniques, steady-state fluorescence and ultraviolet-visible spectroscopic analyses showed that PFBA, PFOA and PFDoA quenched the endogenous GPER fluorescence by combined dynamic and static quenching and non-radiative energy transfer.	perfluorobutyric acid	109-113	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
32743632-3	2020	Among these techniques, steady-state fluorescence and ultraviolet-visible spectroscopic analyses showed that PFBA, PFOA and PFDoA quenched the endogenous GPER fluorescence by combined dynamic and static quenching and non-radiative energy transfer.	perfluorooctanoic acid	115-119	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
32743632-3	2020	Among these techniques, steady-state fluorescence and ultraviolet-visible spectroscopic analyses showed that PFBA, PFOA and PFDoA quenched the endogenous GPER fluorescence by combined dynamic and static quenching and non-radiative energy transfer.	perfluorododecanoic acid	124-129	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
32743632-5	2020	Fourier transform infrared spectroscopy and three-dimensional fluorescence showed that the secondary structure of the GPER changed after binding to PFCAs.	pfcas	148-153	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
32743632-6	2020	Thermodynamic analysis showed DeltaG < 0, which indicated that the interaction between the GPER and PFCAs was spontaneous.	pfcas	100-105	G protein-coupled estrogen receptor 1	Homo sapiens	91-95
32743632-7	2020	For the binding of PFBA and PFOA to the GPER, DeltaH > 0 and DeltaS > 0, indicating that the interaction was mainly driven by hydrophobic forces; for the binding of PFDoA to the GPER, DeltaH < 0 and DeltaS < 0, suggesting that van der Waals force and hydrogen bonding were the main interaction forces.	Hydrogen	251-259	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfca	72-76	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfca	72-76	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfca	72-76	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfcas	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfcas	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
32743632-8	2020	Molecular dynamics simulations suggested that the stability of the GPER-PFCA complexes was higher than that of the free GPER, and also that the structure and hydrophobicity of the GPER changed after binding to PFCAs.	pfcas	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
32743632-9	2020	Molecular docking analysis showed that all three PFCAs could form hydrogen bonds with the GPER, which improved the stability of the complex.	Hydrogen	66-74	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
32743632-0	2020	Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled estrogen receptor: spectroscopic analyses and computational simulations.	Carboxylic Acids	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	84-119
32743632-1	2020	In this paper, perfluorinated compounds (PFCs), such as perfluorobutyric acid (PFBA), perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA), were selected as typical representatives of perfluorinated carboxylic acids (PFCAs) to study the effects of PFCAs on the G protein-coupled estrogen receptor (GPER).	perfluorinated compounds	15-39	G protein-coupled estrogen receptor 1	Homo sapiens	275-310
32743632-1	2020	In this paper, perfluorinated compounds (PFCs), such as perfluorobutyric acid (PFBA), perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA), were selected as typical representatives of perfluorinated carboxylic acids (PFCAs) to study the effects of PFCAs on the G protein-coupled estrogen receptor (GPER).	perfluorinated compounds	15-39	G protein-coupled estrogen receptor 1	Homo sapiens	312-316
32743632-1	2020	In this paper, perfluorinated compounds (PFCs), such as perfluorobutyric acid (PFBA), perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA), were selected as typical representatives of perfluorinated carboxylic acids (PFCAs) to study the effects of PFCAs on the G protein-coupled estrogen receptor (GPER).	pfcs	41-45	G protein-coupled estrogen receptor 1	Homo sapiens	275-310
32743632-1	2020	In this paper, perfluorinated compounds (PFCs), such as perfluorobutyric acid (PFBA), perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA), were selected as typical representatives of perfluorinated carboxylic acids (PFCAs) to study the effects of PFCAs on the G protein-coupled estrogen receptor (GPER).	pfcs	41-45	G protein-coupled estrogen receptor 1	Homo sapiens	312-316
32249236-7	2020	GPR30 is activated by other endogenous estrogens, estrone and estriol.	Estrone	50-57	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32249236-7	2020	GPR30 is activated by other endogenous estrogens, estrone and estriol.	Estriol	62-69	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32249236-8	2020	Moreover, GPR30 activation by zearalenone, a nonsteroidal mycoestrogen, suppresses LH secretion.	Zearalenone	30-41	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Calcium	196-203	G protein-coupled estrogen receptor 1	Homo sapiens	50-54
32249236-8	2020	Moreover, GPR30 activation by zearalenone, a nonsteroidal mycoestrogen, suppresses LH secretion.	Luteinizing Hormone	83-85	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Calcium	196-203	G protein-coupled estrogen receptor 1	Homo sapiens	74-79
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Cyclic AMP	218-222	G protein-coupled estrogen receptor 1	Homo sapiens	13-48
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Cyclic AMP	218-222	G protein-coupled estrogen receptor 1	Homo sapiens	50-54
32973677-5	2020	Besides, the G protein-coupled estrogen receptor (GPER, formerly known as GPR30) was recently described as a seven-transmembrane receptor that mediates non-genomic estrogenic signaling, including calcium mobilization, cAMP synthesis, cleavage of matrix metalloproteinases, transactivation of epidermal growth factor receptor (EGFR), and the subsequent activation of PI3K and MAPK signaling pathways, which are the reasons why it is related to cellular processes, such as cell-cycle progression, cellular proliferation, differentiation, apoptosis, migration, and invasion.	Cyclic AMP	218-222	G protein-coupled estrogen receptor 1	Homo sapiens	74-79
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	tphp	206-210	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32849310-1	2020	G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory.	Estradiol	106-115	G protein-coupled estrogen receptor 1	Homo sapiens	0-35
32849310-1	2020	G protein-coupled estrogen receptor (GPER) in the amygdala and the dorsal hippocampus mediates actions of estradiol on anxiety, social recognition and spatial memory.	Estradiol	106-115	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
32325111-0	2020	Bisphenol A induces focal adhesions assembly and activation of FAK, Src and ERK2 via GPER in MDA-MB-231 breast cancer cells.	bis(4-hydroxyphenyl)sulfone	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	85-89
32325111-4	2020	The G protein-coupled estrogen receptor (GPER) is a G protein-coupled receptor coupled with Gs proteins that is activated by estrogen and estrogenic compounds and it is the receptor for BPA.	bisphenol A	186-189	G protein-coupled estrogen receptor 1	Homo sapiens	4-39
32325111-4	2020	The G protein-coupled estrogen receptor (GPER) is a G protein-coupled receptor coupled with Gs proteins that is activated by estrogen and estrogenic compounds and it is the receptor for BPA.	bisphenol A	186-189	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
32325111-6	2020	Here, we demonstrate that BPA induces an increase of GPER expression and activation of FAK, Src and ERK2, and an increase of focal adhesion assembly via GPER in TNBC MDA-MB-231 cells.	bisphenol A	26-29	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
32325111-6	2020	Here, we demonstrate that BPA induces an increase of GPER expression and activation of FAK, Src and ERK2, and an increase of focal adhesion assembly via GPER in TNBC MDA-MB-231 cells.	bisphenol A	26-29	G protein-coupled estrogen receptor 1	Homo sapiens	153-157
32325111-8	2020	Collectively our data showed that BPA via GPER and/or EGFR transactivation induces activation of signal transduction pathways that mediate migration in TNBC MDA-MB-231 cells.	bisphenol A	34-37	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
31967341-4	2020	However, whether GPER is involved in estrogen-dependent visceral hypersensitivity via mast cell degranulation is still unknown.	Estrogens	37-45	G protein-coupled estrogen receptor 1	Homo sapiens	17-21
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	tphp	206-210	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	N-(3,4,5-trichlorophenyl)succinimide	212-215	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	N-(3,4,5-trichlorophenyl)succinimide	212-215	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	2-methyl-1,1-diphenyl-3-(1-pyrrolidyl)-1-propanol	217-221	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	2-methyl-1,1-diphenyl-3-(1-pyrrolidyl)-1-propanol	217-221	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	ippdp	223-228	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	ippdp	223-228	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	Cytidine Diphosphate	230-233	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	Cytidine Diphosphate	230-233	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	mphp	238-242	G protein-coupled estrogen receptor 1	Homo sapiens	107-136
32766240-9	2020	The GPER antagonist G15 and siGPER obviously abolished the above effects by icariin.	icariin	76-83	G protein-coupled estrogen receptor 1	Homo sapiens	4-8
32766240-0	2020	Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.	icariin	0-7	G protein-coupled estrogen receptor 1	Homo sapiens	139-143
32330712-6	2020	The results from the E-SCREEN assay showed that all tested OPFRs except TMP had estrogenic properties, and G protein-coupled receptor 30 (GPR30) was involved in the estrogenicity of eight OPFRs, TiBP, THP, TPhP, TCP, MDPP, IPPDP, CDP and MPhP.	mphp	238-242	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
32587576-8	2020	Interestingly, GPER is reported to mediate many of the rapid responses of estradiol in the adult brain, and is widely distributed in the mammalian brain including the plasma membrane of hippocampal neurons (23-31).	Estradiol	74-83	G protein-coupled estrogen receptor 1	Homo sapiens	15-19
32682779-0	2020	Panax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells.	monobutyl phthalate	58-77	G protein-coupled estrogen receptor 1	Homo sapiens	91-96
32682779-0	2020	Panax ginseng metabolite (GIM-1) modulates the effects of monobutyl phthalate (MBP) on the GPR30/GPER1 canonical pathway in human Sertoli cells.	monobutyl phthalate	58-77	G protein-coupled estrogen receptor 1	Homo sapiens	97-102
32682779-1	2020	This study was performed to evaluate the effect of monobutyl phthalate (MBP) on GPR30-activated pathways in Sertoli cells.	monobutyl phthalate	51-70	G protein-coupled estrogen receptor 1	Homo sapiens	80-85
32138466-3	2020	A modified protein lipid overlay assay (PLO) was used t  o further verify whether EPA was a ligand of GPR30 in ES2 cells.	Eicosapentaenoic Acid	82-85	G protein-coupled estrogen receptor 1	Homo sapiens	102-107
32138466-5	2020	Finally, inhibitory effect of EPA on tumor growth via GPR30 was determined in vitro and in vivo.	Eicosapentaenoic Acid	30-33	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
32138466-6	2020	Results: EPA suppressed ES2 ovarian clear cell carcinoma cells growth via GPR30, a novel EPA receptor, by inducing apoptosis.	Eicosapentaenoic Acid	9-12	G protein-coupled estrogen receptor 1	Homo sapiens	74-79
32138466-7	2020	As a ligand of GPR30, EPA activated the GPR30-cAMP-PKA signaling pathway.	Eicosapentaenoic Acid	22-25	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
32138466-7	2020	As a ligand of GPR30, EPA activated the GPR30-cAMP-PKA signaling pathway.	Eicosapentaenoic Acid	22-25	G protein-coupled estrogen receptor 1	Homo sapiens	40-45
32138466-7	2020	As a ligand of GPR30, EPA activated the GPR30-cAMP-PKA signaling pathway.	Cyclic AMP	46-50	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
32138466-7	2020	As a ligand of GPR30, EPA activated the GPR30-cAMP-PKA signaling pathway.	Cyclic AMP	46-50	G protein-coupled estrogen receptor 1	Homo sapiens	40-45
32138466-11	2020	Conclusion: These results confirm that EPA is a tumor suppressor in human ovarian clear cell carcinoma cells and functions through a novel fatty acid receptor, GPR30, indicating a mechanistic linkage between omega-3 fatty acids and cancers.	Eicosapentaenoic Acid	39-42	G protein-coupled estrogen receptor 1	Homo sapiens	160-165
32138466-11	2020	Conclusion: These results confirm that EPA is a tumor suppressor in human ovarian clear cell carcinoma cells and functions through a novel fatty acid receptor, GPR30, indicating a mechanistic linkage between omega-3 fatty acids and cancers.	Fatty Acids, Omega-3	208-227	G protein-coupled estrogen receptor 1	Homo sapiens	160-165
32587576-9	2020	GPER modulates second messenger signaling cascades involving Galphas- and Galphai/o-associated increase in cyclic adenosine monophosphate and phosphoinositide 3-kinase or Src protein kinase respectively (32, 33).	Adenosine	114-123	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
32587576-10	2020	Activation of GPER is also associated with phospholipase C, and the inositol receptor and ryanodine receptor-mediated increase in intracellular calcium (24, 34).	Calcium	144-151	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
32647687-4	2020	Results: Estradiol inhibited the proliferation of VSMCs by upregulating the expression of ESR1, ESR2, and GPER and downregulating the expression of caspase-3, MYOCD, and SRF, thereby inhibiting the apoptosis of vascular smooth muscle.	Estradiol	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
32487604-0	2020	Interaction Between CCL18 and GPR30 Differs from the Interaction Between Estradiol and GPR30.	Estradiol	73-82	G protein-coupled estrogen receptor 1	Homo sapiens	87-92
32487604-2	2020	The Gs-coupled seven-transmembrane receptor GPR30 is known as both a CCL18 and an estrogen receptor; its activation by estradiol leads to a transactivation of membrane-tethered pro-heparin-binding EGF-like growth factor and the MAPK/ERK pathway.	Estradiol	119-128	G protein-coupled estrogen receptor 1	Homo sapiens	44-49
32401166-4	2020	Here, we report that 17beta-estradiol (E2), TAM, and FUL stabilize MORC2 (MORC family CW-type zinc finger 2), an emerging oncoprotein in human cancer, in a GPER1-dependent manner.	Estradiol	21-37	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32487604-6	2020	RESULTS: Many similarities on the effect of CCL18 on the already known estradiol-activated signaling pathway via the G protein-coupled estrogen receptor GPR30 were identified.	Estradiol	71-80	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
32487604-11	2020	This is a rather unexpected result, because the estrogen estradiol and CCL18 both activate GPR30.	Estradiol	57-66	G protein-coupled estrogen receptor 1	Homo sapiens	91-96
32487604-18	2020	CCL18 and estradiol may not lead to the same signaling pathway after activating GPR30.	Estradiol	10-19	G protein-coupled estrogen receptor 1	Homo sapiens	80-85
32401166-4	2020	Here, we report that 17beta-estradiol (E2), TAM, and FUL stabilize MORC2 (MORC family CW-type zinc finger 2), an emerging oncoprotein in human cancer, in a GPER1-dependent manner.	Estradiol	39-41	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32401166-4	2020	Here, we report that 17beta-estradiol (E2), TAM, and FUL stabilize MORC2 (MORC family CW-type zinc finger 2), an emerging oncoprotein in human cancer, in a GPER1-dependent manner.	Tamoxifen	44-47	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32401166-5	2020	Mechanistically, GPER1 activates PRKACA (protein kinase cAMP-activated catalytic subunit alpha), which in turn phosphorylates MORC2 at threonine 582 (T582).	Threonine	135-144	G protein-coupled estrogen receptor 1	Homo sapiens	17-22
32670863-8	2020	Finally, the study identified targeting AhR and/or GPR30 with specific antagonists as a strategy capable of inhibiting carcinogenesis associated with chronic exposure to low doses of B[a]P and BPA in MCF10AT1 cells.	bisphenol A	193-196	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
32390531-13	2020	These results highlight GPER as a potential therapeutic target for salt-sensitive hypertension in postmenopausal women.	Salts	67-71	G protein-coupled estrogen receptor 1	Homo sapiens	24-28
32361597-0	2020	GPER1 Signaling Initiates Migration of Female V-SVZ-Derived Cells.	svz	48-51	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32361597-5	2020	Blocking of GPER1 in Matrigel cultures of female animals significantly impairs migration of V-SVZ-derived cells.	svz	94-97	G protein-coupled estrogen receptor 1	Homo sapiens	12-17
32670863-0	2020	Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay.	Benzo(a)pyrene	76-90	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32670863-0	2020	Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay.	bis(4-hydroxyphenyl)sulfone	98-107	G protein-coupled estrogen receptor 1	Homo sapiens	156-161
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	130-159
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	Benzo(a)pyrene	210-215	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	bisphenol A	223-226	G protein-coupled estrogen receptor 1	Homo sapiens	130-159
32670863-5	2020	This study provided new insights into the existence of a functional interplay between the aryl hydrocarbon receptor (AhR) and the G protein-coupled receptor 30 (GPR30) by which chronic and low-dose exposure of B[a]P and/or BPA fosters the progression of MCF10AT1 cells into a more aggressive substage.	bisphenol A	223-226	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
32670863-6	2020	Experiments using AhR or GPR30 antagonists, siRNA strategies, and RNAseq analysis led us to propose a model in which AhR signaling plays a "driver role" in the AhR/GPR30 cross-talk in mediating long-term and low-dose exposure of B[a]P and/or BPA.	Phosphorus	26-27	G protein-coupled estrogen receptor 1	Homo sapiens	164-169
32670863-6	2020	Experiments using AhR or GPR30 antagonists, siRNA strategies, and RNAseq analysis led us to propose a model in which AhR signaling plays a "driver role" in the AhR/GPR30 cross-talk in mediating long-term and low-dose exposure of B[a]P and/or BPA.	bisphenol A	242-245	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
32670863-6	2020	Experiments using AhR or GPR30 antagonists, siRNA strategies, and RNAseq analysis led us to propose a model in which AhR signaling plays a "driver role" in the AhR/GPR30 cross-talk in mediating long-term and low-dose exposure of B[a]P and/or BPA.	bisphenol A	242-245	G protein-coupled estrogen receptor 1	Homo sapiens	164-169
32670863-8	2020	Finally, the study identified targeting AhR and/or GPR30 with specific antagonists as a strategy capable of inhibiting carcinogenesis associated with chronic exposure to low doses of B[a]P and BPA in MCF10AT1 cells.	Benzo(a)pyrene	183-188	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
32087276-0	2020	GPER mediates decreased chemosensitivity via regulation of ABCG2 expression and localization in tamoxifen-resistant breast cancer cells.	Tamoxifen	96-105	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
32197950-3	2020	Herein, was studied the role of aromatase activation and the GPER1 pathway on sodium arsenite-induced promotion and progression of MDA-MB-231 and MDA-MB-453 BCa cell lines.	sodium arsenite	78-93	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	53-58
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	226-231
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	sodium arsenite	103-118	G protein-coupled estrogen receptor 1	Homo sapiens	53-58
32440148-9	2020	Conclusion: GPR30 may contribute to the pathogenesis of LEVVs by promoting the maintenance of a synthetic phenotype in VSMCs by activating the ERK1/2 and AKT pathways, and GPR30 might be a novel therapeutic target for clinical LEVV treatment.	levv	56-60	G protein-coupled estrogen receptor 1	Homo sapiens	12-17
32069725-3	2020	Herein, a previously developed membrane electrochemical reactor (MER) was coupled with Fenton oxidation through providing synergistic benefits with the low solution pH, reduced organics, and ammonia removal/recovery.	Ammonia	191-198	G protein-coupled estrogen receptor 1	Homo sapiens	31-63
32069725-3	2020	Herein, a previously developed membrane electrochemical reactor (MER) was coupled with Fenton oxidation through providing synergistic benefits with the low solution pH, reduced organics, and ammonia removal/recovery.	Ammonia	191-198	G protein-coupled estrogen receptor 1	Homo sapiens	65-68
32069725-6	2020	At a dimensionless oxidant dose of 1.0, the coupled MER-Fenton system reduced the consumption of both FeSO4 7H2O and H2O2 by 39%, H2SO4 by 100%, and NaOH by 55%.	feso4 7h2o	102-112	G protein-coupled estrogen receptor 1	Homo sapiens	52-55
32069725-6	2020	At a dimensionless oxidant dose of 1.0, the coupled MER-Fenton system reduced the consumption of both FeSO4 7H2O and H2O2 by 39%, H2SO4 by 100%, and NaOH by 55%.	Hydrogen Peroxide	117-121	G protein-coupled estrogen receptor 1	Homo sapiens	52-55
32069725-6	2020	At a dimensionless oxidant dose of 1.0, the coupled MER-Fenton system reduced the consumption of both FeSO4 7H2O and H2O2 by 39%, H2SO4 by 100%, and NaOH by 55%.	sulfuric acid	130-135	G protein-coupled estrogen receptor 1	Homo sapiens	52-55
32069725-6	2020	At a dimensionless oxidant dose of 1.0, the coupled MER-Fenton system reduced the consumption of both FeSO4 7H2O and H2O2 by 39%, H2SO4 by 100%, and NaOH by 55%.	Sodium Hydroxide	149-153	G protein-coupled estrogen receptor 1	Homo sapiens	52-55
32069725-9	2020	More notably, direct Fenton oxidation removed only 21% of ammonia; in comparison the MER-Fenton system removed ammonia by 98% with the possibility for recovery at a rate of 30.6-55.2 kg N m-3 reactor d-1.	Ammonia	111-118	G protein-coupled estrogen receptor 1	Homo sapiens	85-88
32069725-10	2020	Those results demonstrate that coupling MER with Fenton process could mitigate some inherent drawbacks of Fenton oxidation such as ineffective ammonia removal, high acid and chemical reagents dose requirements, and a large amount of sludge generation.	Ammonia	143-150	G protein-coupled estrogen receptor 1	Homo sapiens	40-43
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	sodium arsenite	103-118	G protein-coupled estrogen receptor 1	Homo sapiens	226-231
32197950-7	2020	Overall, data suggests that sodium arsenite induces a positive-feedback loop, resulting in the promotion and progression of BCa cells, through induction of aromatase activity, E2 production, GPER1 stimulation, and Src activation.	sodium arsenite	28-43	G protein-coupled estrogen receptor 1	Homo sapiens	191-196
32357920-0	2020	Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells.	cryptotanshinone	98-114	G protein-coupled estrogen receptor 1	Homo sapiens	53-79
32357920-0	2020	Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells.	cryptotanshinone	98-114	G protein-coupled estrogen receptor 1	Homo sapiens	80-84
32323852-5	2020	In addition, through transient expression assays in breast cancer cells, it was revealed that a transcriptional mechanism dependent on protein kinase A and susceptible to retinoic acid in ER-positive cells induces GPR30 expression through a cis-regulatory element for E26 transformation-specific transcription factors, located between -631 and -625 bp from the GPR30 translation start codon.	Tretinoin	171-184	G protein-coupled estrogen receptor 1	Homo sapiens	214-219
32323852-5	2020	In addition, through transient expression assays in breast cancer cells, it was revealed that a transcriptional mechanism dependent on protein kinase A and susceptible to retinoic acid in ER-positive cells induces GPR30 expression through a cis-regulatory element for E26 transformation-specific transcription factors, located between -631 and -625 bp from the GPR30 translation start codon.	Tretinoin	171-184	G protein-coupled estrogen receptor 1	Homo sapiens	361-366
32302351-2	2020	GPR30 associates with breast cancer (BC) outcome and may contribute to tamoxifen resistance.	Tamoxifen	71-80	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32302351-3	2020	We investigated the expression and prognostic significance of GPR30 in metachronous contralateral breast cancer (CBC) as a model of tamoxifen resistance.	Tamoxifen	132-141	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
32302351-11	2020	However, BC2 that were diagnosed during tamoxifen treatment were more likely to express GPR30PM than BC2 diagnosed after treatment completion (p = 0.01).	Tamoxifen	40-49	G protein-coupled estrogen receptor 1	Homo sapiens	88-93
32302351-12	2020	Furthermore, a trend was observed that patients with GPR30PM in an ER-positive BC2 had greater benefit from tamoxifen treatment.	Tamoxifen	108-117	G protein-coupled estrogen receptor 1	Homo sapiens	53-58
32087276-4	2020	Here, we are the first to show that the expression levels of GPER and ABCG2 are markedly increased in tamoxifen-resistant ER + metastases compared to the corresponding primary tumors.	Tamoxifen	102-111	G protein-coupled estrogen receptor 1	Homo sapiens	61-65
32087276-6	2020	Furthermore, both ER modulator tamoxifen, GPER-specific agonist G1 and pure ER antagonist ICI 182,780 significantly enhanced ABCG2 expression in tamoxifen-resistant breast cancer cells (MCF-7R) but not in tamoxifen-sensitive cells (MCF-7).	Tamoxifen	145-154	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
32087276-6	2020	Furthermore, both ER modulator tamoxifen, GPER-specific agonist G1 and pure ER antagonist ICI 182,780 significantly enhanced ABCG2 expression in tamoxifen-resistant breast cancer cells (MCF-7R) but not in tamoxifen-sensitive cells (MCF-7).	Tamoxifen	145-154	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
32087276-9	2020	More importantly, the tamoxifen-induced GPER/ABCG2 signaling axis was shown to play a pivotal role in the development of chemotherapy (doxorubicin) resistance both in vitro and in vivo.	Tamoxifen	22-31	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
32087276-9	2020	More importantly, the tamoxifen-induced GPER/ABCG2 signaling axis was shown to play a pivotal role in the development of chemotherapy (doxorubicin) resistance both in vitro and in vivo.	Doxorubicin	135-146	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
32087276-10	2020	The clinical data further revealed that tamoxifen-resistant patients with high GPER/ABCG2 signaling activation had poor progression-free survival (PFS) when given rescue anthracycline chemotherapy.	Tamoxifen	40-49	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
32087276-10	2020	The clinical data further revealed that tamoxifen-resistant patients with high GPER/ABCG2 signaling activation had poor progression-free survival (PFS) when given rescue anthracycline chemotherapy.	Anthracyclines	170-183	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
32087276-11	2020	Therefore, our data provide novel insights into GPER-mediated chemoresistance and provide a rationale for the GPER/ABCG2 signaling axis being a promising target for reversing chemoresistance in patients with advanced ER + tamoxifen-resistant breast cancer.	Tamoxifen	222-231	G protein-coupled estrogen receptor 1	Homo sapiens	48-52
32087276-11	2020	Therefore, our data provide novel insights into GPER-mediated chemoresistance and provide a rationale for the GPER/ABCG2 signaling axis being a promising target for reversing chemoresistance in patients with advanced ER + tamoxifen-resistant breast cancer.	Tamoxifen	222-231	G protein-coupled estrogen receptor 1	Homo sapiens	110-114
32030797-0	2020	GPER-regulated lncRNA-Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple-negative breast cancer.	Glutamic Acid	35-44	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
31989268-6	2020	RESULTS: In the MF patients, the GPER-1 level determined of mean 3.68 (1.95-4.26) pg/ml, 17 beta dehydrogenase of 5.25 (2.73-6.77) ng/ml, and cAMP of 24.62 (11.62-30.35) ng/ml were statistically signficantly higher than those of the control group (p = 0.008, p = 0.002, p = 0.003, respectively).	Cyclic AMP	142-146	G protein-coupled estrogen receptor 1	Homo sapiens	33-39
31340060-6	2020	Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics.	Tamoxifen	45-54	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
31340060-6	2020	Activation of GPER by its ligands, including tamoxifen (TMX), induced phosphorylation of PKA and BAD-Ser118 to sustain BCSC characteristics.	Tamoxifen	56-59	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
32094002-6	2020	Then, cell ultrastructure, expression and localization of GPER, ERRbeta, PPARgamma together with the molecular receptor mechanism, through cyclic AMP and Raf/Ras/extracellular signal activated kinases (ERK), in the control of cholesterol concentration and estrogen production by Leydig cells were studied.	Cyclic AMP	139-149	G protein-coupled estrogen receptor 1	Homo sapiens	58-62
32094002-6	2020	Then, cell ultrastructure, expression and localization of GPER, ERRbeta, PPARgamma together with the molecular receptor mechanism, through cyclic AMP and Raf/Ras/extracellular signal activated kinases (ERK), in the control of cholesterol concentration and estrogen production by Leydig cells were studied.	Cholesterol	226-237	G protein-coupled estrogen receptor 1	Homo sapiens	58-62
32001259-4	2020	At the cellular level, the mechanisms by which estrogens regulate diverse cellular functions including reproduction and behavior is by binding to estrogen receptors alpha, beta (ERalpha and ERbeta) and G-protein coupled ER (GPER1).	Estrogens	47-56	G protein-coupled estrogen receptor 1	Homo sapiens	224-229
32001259-4	2020	At the cellular level, the mechanisms by which estrogens regulate diverse cellular functions including reproduction and behavior is by binding to estrogen receptors alpha, beta (ERalpha and ERbeta) and G-protein coupled ER (GPER1).	Estrogens	47-55	G protein-coupled estrogen receptor 1	Homo sapiens	224-229
32036685-0	2020	Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway.	Rutin	0-5	G protein-coupled estrogen receptor 1	Homo sapiens	89-94
32030797-2	2020	TNBC has been recognized as estrogen-independent breast cancer, while the novel estrogen receptor, namely G protein-coupled estrogen receptor (GPER), was claimed to mediate estrogenic actions in TNBC tissues and cell lines.	Estrogens	80-88	G protein-coupled estrogen receptor 1	Homo sapiens	106-141
32030797-2	2020	TNBC has been recognized as estrogen-independent breast cancer, while the novel estrogen receptor, namely G protein-coupled estrogen receptor (GPER), was claimed to mediate estrogenic actions in TNBC tissues and cell lines.	Estrogens	80-88	G protein-coupled estrogen receptor 1	Homo sapiens	143-147
32030797-3	2020	Through mRNA microarrays, lncRNA microarrays, and bioinformatics analysis, we found that GPER is activated by 17beta-estradiol (E2) and GPER-specific agonist G1, which downregulates a novel lncRNA (termed as lncRNA-Glu).	Estradiol	110-126	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
32030797-3	2020	Through mRNA microarrays, lncRNA microarrays, and bioinformatics analysis, we found that GPER is activated by 17beta-estradiol (E2) and GPER-specific agonist G1, which downregulates a novel lncRNA (termed as lncRNA-Glu).	Estradiol	110-126	G protein-coupled estrogen receptor 1	Homo sapiens	136-140
32030797-5	2020	GPER-mediated reduction of lncRNA-Glu promotes glutamate transport activity and transcriptional activity of VGLUT2.	Glutamic Acid	47-56	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
32030797-6	2020	Furthermore, GPER-mediated activation of cAMP-PKA signaling contributes to glutamate secretion.	Cyclic AMP	41-45	G protein-coupled estrogen receptor 1	Homo sapiens	13-17
32030797-6	2020	Furthermore, GPER-mediated activation of cAMP-PKA signaling contributes to glutamate secretion.	Glutamic Acid	75-84	G protein-coupled estrogen receptor 1	Homo sapiens	13-17
32030797-8	2020	Our data provide new insights into GPER-mediated glutamate secretion and its downstream signaling NMDAR-CaMK/MEK-MAPK during TNBC invasion.	Glutamic Acid	49-58	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
31698960-0	2020	Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased oestradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor.	Polycyclic Aromatic Hydrocarbons	14-46	G protein-coupled estrogen receptor 1	Homo sapiens	142-147
31698960-7	2020	This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2.	Polycyclic Aromatic Hydrocarbons	98-101	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
31698960-7	2020	This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2.	Estradiol	114-116	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
32077170-0	2020	The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert.	Estrogens	22-31	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
32052561-0	2020	Cisplatin resistance in gastric cancer cells is involved with GPR30-mediated epithelial-mesenchymal transition.	Cisplatin	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
32052561-3	2020	GPR30 is a novel oestrogen receptor that is involved in the invasion, metastasis and drug resistance of many tumours.	Estrogens	17-26	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32052561-7	2020	In this study, we demonstrated that GPR30 is involved in cisplatin resistance by promoting EMT in gastric cancer.	Cisplatin	57-66	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
32052561-8	2020	GPR30 knockdown resulted in increased sensitivity of different gastric cancer (GC) cells to cisplatin and alterations in the epithelial/mesenchymal markers.	Cisplatin	92-101	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
32052561-12	2020	Taken together, these results revealed the role of GPR30 in the formation of cisplatin resistance, suggesting that targeting GPR30 signalling may be a potential strategy for improving the efficacy of chemotherapy in gastric cancer.	Cisplatin	77-86	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
32052561-12	2020	Taken together, these results revealed the role of GPR30 in the formation of cisplatin resistance, suggesting that targeting GPR30 signalling may be a potential strategy for improving the efficacy of chemotherapy in gastric cancer.	Cisplatin	77-86	G protein-coupled estrogen receptor 1	Homo sapiens	125-130
32077170-0	2020	The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert.	Estrogens	94-104	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
32077170-6	2020	These effects were inhibited by treatment with either 17beta-oestradiol (E2 ) (10 nmol L-1 ) or G1 (100 nmol L-1 ), the selective agonist of the G protein-coupled oestrogen receptor (GPER1).	Estradiol	54-71	G protein-coupled estrogen receptor 1	Homo sapiens	183-188
32077170-6	2020	These effects were inhibited by treatment with either 17beta-oestradiol (E2 ) (10 nmol L-1 ) or G1 (100 nmol L-1 ), the selective agonist of the G protein-coupled oestrogen receptor (GPER1).	Estrogens	163-172	G protein-coupled estrogen receptor 1	Homo sapiens	183-188
32077170-12	2020	The results obtained in the present study indicate a modulatory functional role of GPER1 with respect to mediating the oestrogen neuroprotective effect against inflammation in brain cholinergic neurones and, accordingly, may help to identify protective strategies for preventing cognitive impairments.	Estrogens	119-128	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
31689473-8	2020	Furthermore, in comparison with MCF-7 cells, the LTED cells expressed very low levels of G protein-coupled estrogen receptor 1 (GPER1), a membrane ER capable of stimulating the estrogenic activity of Cd.	Cadmium	200-202	G protein-coupled estrogen receptor 1	Homo sapiens	89-126
32028606-6	2020	RESULTS: Treatment with 3 nM BPA led to an increase in cell number and altered the phosphorylation status of p38, an effect mediated primarily via the membrane-bound estrogen receptor (GPR30).	bisphenol A	29-32	G protein-coupled estrogen receptor 1	Homo sapiens	185-190
32028606-6	2020	RESULTS: Treatment with 3 nM BPA led to an increase in cell number and altered the phosphorylation status of p38, an effect mediated primarily via the membrane-bound estrogen receptor (GPR30).	Estrogens	166-174	G protein-coupled estrogen receptor 1	Homo sapiens	185-190
32046440-8	2020	The effects of BPA on HESCs could be blocked by G protein-coupled estrogen receptor (GPER) inhibitor or mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) inhibitor.	bisphenol A	15-18	G protein-coupled estrogen receptor 1	Homo sapiens	48-83
32046440-8	2020	The effects of BPA on HESCs could be blocked by G protein-coupled estrogen receptor (GPER) inhibitor or mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) inhibitor.	bisphenol A	15-18	G protein-coupled estrogen receptor 1	Homo sapiens	85-89
31981723-6	2020	Furthermore, BPAF exposure at concentrations from 8 to 1000 ng/ml results in an increase in G protein-coupled estrogen receptor (GPER) expression.	4,4'-hexafluorisopropylidene diphenol	13-17	G protein-coupled estrogen receptor 1	Homo sapiens	92-127
31981723-6	2020	Furthermore, BPAF exposure at concentrations from 8 to 1000 ng/ml results in an increase in G protein-coupled estrogen receptor (GPER) expression.	4,4'-hexafluorisopropylidene diphenol	13-17	G protein-coupled estrogen receptor 1	Homo sapiens	129-133
32075246-1	2020	The peptide ERalpha17p, which corresponds to the 295-311 fragment of the hinge/AF2 domains of the human estrogen receptor alpha (ERalpha), exerts apoptosis in breast cancer cells through a mechanism involving the G protein-coupled estrogen-dependent receptor GPER.	Estrogens	104-112	G protein-coupled estrogen receptor 1	Homo sapiens	259-263
31900584-0	2020	GPER-1 expression is associated with a decreased response rate to primary tamoxifen therapy of breast cancer patients.	Tamoxifen	74-83	G protein-coupled estrogen receptor 1	Homo sapiens	0-6
31900584-11	2020	We observed a continuous reduction of mean tumor size in patients treated with aromatase inhibitors irrespective of the GPER-1 status and in GPER-1 negative patients treated with TAM.	Tamoxifen	179-182	G protein-coupled estrogen receptor 1	Homo sapiens	141-147
31900584-12	2020	In contrast, in GPER-1 positive patients treated with TAM, a reduction of mean tumor size was observed only in the first 2 months after beginning of treatment.	Tamoxifen	54-57	G protein-coupled estrogen receptor 1	Homo sapiens	16-22
31900584-14	2020	CONCLUSIONS: GPER-1 expression is significantly associated with a reduced effect of primary treatment with tamoxifen in breast cancer patients.	Tamoxifen	107-116	G protein-coupled estrogen receptor 1	Homo sapiens	13-19
31689473-8	2020	Furthermore, in comparison with MCF-7 cells, the LTED cells expressed very low levels of G protein-coupled estrogen receptor 1 (GPER1), a membrane ER capable of stimulating the estrogenic activity of Cd.	Cadmium	200-202	G protein-coupled estrogen receptor 1	Homo sapiens	128-133
32082252-0	2019	17beta-Estradiol Inhibits PCSK9-Mediated LDLR Degradation Through GPER/PLC Activation in HepG2 Cells.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
32082252-5	2019	Here, we report that 17beta-estradiol (betaE2) reduces PCSK9-mediated LDLR degradation by a mechanism that involves activation of the G protein-coupled estrogen receptor (GPER).	Estradiol	21-37	G protein-coupled estrogen receptor 1	Homo sapiens	134-169
32082252-5	2019	Here, we report that 17beta-estradiol (betaE2) reduces PCSK9-mediated LDLR degradation by a mechanism that involves activation of the G protein-coupled estrogen receptor (GPER).	Estradiol	21-37	G protein-coupled estrogen receptor 1	Homo sapiens	171-175
31790688-2	2020	As 17-beta-estradiol (E2) has been shown to have a proliferative effect on benign and malignant thyroid cells, G protein-coupled estrogen receptor (GPER1) could have a role on the pathogenesis of thyroid cancer.	Estrogens	129-137	G protein-coupled estrogen receptor 1	Homo sapiens	148-153
31991740-4	2020	Agonists of the G protein-coupled oestrogen receptor (GPER), such as tamoxifen, have been largely used in the clinic, and interest in GPER, which is abundantly expressed in tissues, has greatly increased despite a lack of understanding regarding the mechanisms which promote its multiple effects.	Tamoxifen	69-78	G protein-coupled estrogen receptor 1	Homo sapiens	16-52
31991740-4	2020	Agonists of the G protein-coupled oestrogen receptor (GPER), such as tamoxifen, have been largely used in the clinic, and interest in GPER, which is abundantly expressed in tissues, has greatly increased despite a lack of understanding regarding the mechanisms which promote its multiple effects.	Tamoxifen	69-78	G protein-coupled estrogen receptor 1	Homo sapiens	54-58
31759979-0	2020	Regulation of Beta Adrenoceptor-mediated Myocardial Contraction and Calcium Dynamics by the G Protein-coupled Estrogen Receptor 1.	Calcium	68-75	G protein-coupled estrogen receptor 1	Homo sapiens	92-129
31993020-1	2019	The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor that mediates non-genomic actions of the primary female sex hormone 17beta-estradiol.	Estradiol	150-166	G protein-coupled estrogen receptor 1	Homo sapiens	4-39
31993020-1	2019	The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor that mediates non-genomic actions of the primary female sex hormone 17beta-estradiol.	Estradiol	150-166	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
31993020-3	2019	This review will focus specifically on the cardiac actions of GPER, since this receptor is expressed in cardiomyocytes as well as other cells within the heart and most likely contributes to estrogen-induced cardioprotection.	Estrogens	190-198	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
31759979-5	2020	Administration of the GPER agonist G-1 during the plateau phase of isoproterenol-induced LVP increase rapidly restores LVP to baseline levels and reduces the frequency of ectopic contractions.	Isoproterenol	67-80	G protein-coupled estrogen receptor 1	Homo sapiens	22-26
31759979-13	2020	Our data indicate that GPER functions as an intrinsic component of beta1AR signaling to moderate myocardial Ca2+ dynamics and contraction.	Calcium	108-112	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
31920512-8	2019	The GPER antagonist G15, the PLC inhibitor U73122 and the IP3 receptor inhibitor 2-APB each virtually abolished the calcium responses to E2 or G-1.	Calcium	116-123	G protein-coupled estrogen receptor 1	Homo sapiens	4-8
31706983-2	2019	In addition to the classical nuclear estrogen receptors (ERalpha and ERbeta), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action.	Estrogens	100-108	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
31706983-2	2019	In addition to the classical nuclear estrogen receptors (ERalpha and ERbeta), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action.	Estrogens	100-108	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
31920512-0	2019	Activation of the G Protein-Coupled Estrogen Receptor Elicits Store Calcium Release and Phosphorylation of the Mu-Opioid Receptors in the Human Neuroblastoma SH-SY5Y Cells.	Calcium	68-75	G protein-coupled estrogen receptor 1	Homo sapiens	18-53
31920512-4	2019	The receptors responsible for the rapid actions of estrogens remain uncertain, but recent evidence points to the G protein-coupled estrogen receptor (GPER), which has been shown to be expressed widely in the nervous system.	Estrogens	51-60	G protein-coupled estrogen receptor 1	Homo sapiens	113-148
31920512-11	2019	In conclusion, the present study has revealed a novel GPER-mediated estrogenic signaling in neuroblastoma cells in which activation of GPER is followed by rapid calcium mobilization, PKC activation and MOR phosphorylation.	Calcium	161-168	G protein-coupled estrogen receptor 1	Homo sapiens	54-58
31920512-4	2019	The receptors responsible for the rapid actions of estrogens remain uncertain, but recent evidence points to the G protein-coupled estrogen receptor (GPER), which has been shown to be expressed widely in the nervous system.	Estrogens	51-60	G protein-coupled estrogen receptor 1	Homo sapiens	150-154
31920512-5	2019	In the current study, we test the hypothesis that activation of GPER may mediate rapid calcium signaling, which may promote phosphorylation of MOR through the calcium-dependent protein kinases in neuronal cells.	Calcium	87-94	G protein-coupled estrogen receptor 1	Homo sapiens	64-68
31920512-12	2019	GPER-mediated rapid calcium signal may also be transmitted to the nucleus to impact on gene transcription.	Calcium	20-27	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
31920512-5	2019	In the current study, we test the hypothesis that activation of GPER may mediate rapid calcium signaling, which may promote phosphorylation of MOR through the calcium-dependent protein kinases in neuronal cells.	Calcium	159-166	G protein-coupled estrogen receptor 1	Homo sapiens	64-68
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Estradiol	22-38	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
31125081-0	2019	Aldosterone Stimulates Its Biosynthesis Via A Novel GPER Mediated Mechanism.	Aldosterone	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	52-56
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Estradiol	22-38	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Calcium	92-99	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Calcium	92-99	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Calcium	185-192	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
31920512-7	2019	Activation of GPER by 17beta-estradiol (E2) and G-1 (GPER selective agonist) evoked a rapid calcium rise in a concentration-dependent manner, which was due to store release rather than calcium entry.	Calcium	185-192	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
31568691-7	2019	Transcriptome analysis indicated activation of G-protein-coupled estrogen receptor (GPER1) as the main underlying mechanism of action, which was corroborated using GPER1-selective agonists and antagonists.	Estrogens	65-73	G protein-coupled estrogen receptor 1	Homo sapiens	84-89
31568691-7	2019	Transcriptome analysis indicated activation of G-protein-coupled estrogen receptor (GPER1) as the main underlying mechanism of action, which was corroborated using GPER1-selective agonists and antagonists.	Estrogens	65-73	G protein-coupled estrogen receptor 1	Homo sapiens	164-169
31125081-1	2019	CONTEXT: The G protein-coupled estrogen receptor (GPER) mediates an aldosterone secretagogue effect of 17beta-estradiol in human HAC15 adrenocortical cells after estrogen receptor beta blockade.	Estradiol	103-119	G protein-coupled estrogen receptor 1	Homo sapiens	13-48
31125081-1	2019	CONTEXT: The G protein-coupled estrogen receptor (GPER) mediates an aldosterone secretagogue effect of 17beta-estradiol in human HAC15 adrenocortical cells after estrogen receptor beta blockade.	Estradiol	103-119	G protein-coupled estrogen receptor 1	Homo sapiens	50-54
31125081-2	2019	As GPER mediates mineralocorticoid receptor-independent aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its own synthesis via GPER activation.	Aldosterone	56-67	G protein-coupled estrogen receptor 1	Homo sapiens	3-7
31125081-6	2019	RESULTS: Aldosterone markedly increased CYP11B2 mRNA and protein expression (vs untreated samples, p&lt;0.001) in both models by acting via GPER, as these effects were abolished by G36 (p&lt;0.01) and not by canrenone.	Canrenone	208-217	G protein-coupled estrogen receptor 1	Homo sapiens	140-144
31125081-7	2019	GPER-silencing (p&lt;0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis.	Aldosterone	41-52	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
31125081-7	2019	GPER-silencing (p&lt;0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis.	Aldosterone	41-52	G protein-coupled estrogen receptor 1	Homo sapiens	121-125
31125081-7	2019	GPER-silencing (p&lt;0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis.	Aldosterone	100-111	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
31125081-7	2019	GPER-silencing (p&lt;0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis.	Aldosterone	100-111	G protein-coupled estrogen receptor 1	Homo sapiens	121-125
31125081-8	2019	Angiotensin II potentiated the GPER-mediated effect of aldosterone on CYP11B2.	Aldosterone	55-66	G protein-coupled estrogen receptor 1	Homo sapiens	31-35
31125081-11	2019	Moreover, as aldosterone-producing adenoma overexpresses GPER this mechanism could contribute to the aldosterone excess that occurs in primary aldosteronism in a seemingly autonomous fashion from angiotensin II.	Aldosterone	13-24	G protein-coupled estrogen receptor 1	Homo sapiens	57-61
31499072-3	2019	We have recently discovered a role of estrogen receptors (ER) in controlling aldosterone biosynthesis in the human adrenocortical zona glomerulosa, which expresses both the classical ERalpha and beta receptors and G protein-coupled estrogen receptor (GPER).	Aldosterone	77-88	G protein-coupled estrogen receptor 1	Homo sapiens	214-249
31950019-0	2019	Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target.	Genistein	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
31950019-10	2019	Treatment of BRCA1 silenced breast cancer cells with genistein resulted in the down-regulation of GPR30 expression and the inhibition of Akt phosphorylation as well as the reduced cell viability, migration and colony formation.	Genistein	53-62	G protein-coupled estrogen receptor 1	Homo sapiens	98-103
31950019-15	2019	Genistein induces G2/M phase arrest by down-regulating cyclin B1 expression, which is attributable to its suppression of GPR30 activation and Akt phosphorylation in BRCA1 impaired breast cancer cells.	Genistein	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	121-126
31499072-5	2019	We found that 17 beta -estradiol exerts a dual effect: it blunts aldosterone production via ERbeta, but displays a potent aldosterone secretagogue effect via GPER activation after ERbeta blockade.	Estradiol	14-32	G protein-coupled estrogen receptor 1	Homo sapiens	158-162
31499072-8	2019	Our purpose here was to provide an update on estrogen receptor function in the normal adrenal cortex and its relevance for the sex differences in blood pressure in light of the newly discovered role of GPER in regulating aldosterone synthesis.	Aldosterone	221-232	G protein-coupled estrogen receptor 1	Homo sapiens	202-206
31279203-4	2019	Compared to a control reactor that did not have a membrane separator, the MER achieved significantly higher removals of both dissolved organic carbon (61.5 +- 4.1%) and UV254nm absorbance (63.4 +- 8.4%).	Carbon	143-149	G protein-coupled estrogen receptor 1	Homo sapiens	74-77
31759407-5	2019	While in our previous studies altered GPER-PPAR partnership was found in human LCT being a possible cause and/or additionally effecting on LCT development, here mouse testes with experimentally induced LCT and mouse tumor Leydig cell (MA-10) treated with BPA chemicals were examined.	4-boronophenylalanine-fructose	255-258	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
31545985-8	2019	Furthermore, shikonin downregulated the expression of ERalpha and GPER, and this effect was not affected by the estrogen environment.	shikonin	13-21	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
31546233-0	2019	Low Dose Bisphenol-A Regulates Inflammatory Cytokines through GPR30 in Mammary Adipose Cells.	bisphenol A	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
31546233-3	2019	24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells.	bisphenol A	31-34	G protein-coupled estrogen receptor 1	Homo sapiens	211-249
31546233-3	2019	24 and/or 48 hours exposure to BPA 0.1 nM elicited significant increase of the inflammatory molecules interleukin-6 (IL-6), interleukin-8 (IL-8), Monocyte chemo-attractant protein 1alpha (MCP1alpha) and induced G protein-coupled estrogen receptor 30 (GPR30) levels more than 2-fold both in mature adipocytes and SVF cells.	bisphenol A	31-34	G protein-coupled estrogen receptor 1	Homo sapiens	251-256
31546233-5	2019	As a result of BPA-GPR30 signaling activation, Fatty Acid Synthase (FAS) and leptin mRNA levels were significantly higher upon BPA exposure (p&lt;0.05) in mature adipocytes, with an opposite effect on adiponectin (ADIPOQ).	bisphenol A	15-18	G protein-coupled estrogen receptor 1	Homo sapiens	19-24
31546233-5	2019	As a result of BPA-GPR30 signaling activation, Fatty Acid Synthase (FAS) and leptin mRNA levels were significantly higher upon BPA exposure (p&lt;0.05) in mature adipocytes, with an opposite effect on adiponectin (ADIPOQ).	bisphenol A	127-130	G protein-coupled estrogen receptor 1	Homo sapiens	19-24
31546233-9	2019	All these data suggest that BPA at 0.1nM, a 10 times lower concentration than environmental exposure, increases the expression of pro-inflammatory cytokines via GPR30 both in mature mammary adipocytes and in SVF cells with a possible involvement of IL-8.	bisphenol A	28-31	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
31279203-6	2019	The MER was able to remove 89.1 +- 2.9% of total nitrogen from the leachate while recovering about 51% of the influent ammonia in the catholyte, in comparison to 38.1 +- 4.4% of total nitrogen removal by the control reactor.	Nitrogen	49-57	G protein-coupled estrogen receptor 1	Homo sapiens	4-7
31279203-6	2019	The MER was able to remove 89.1 +- 2.9% of total nitrogen from the leachate while recovering about 51% of the influent ammonia in the catholyte, in comparison to 38.1 +- 4.4% of total nitrogen removal by the control reactor.	Ammonia	119-126	G protein-coupled estrogen receptor 1	Homo sapiens	4-7
31279203-6	2019	The MER was able to remove 89.1 +- 2.9% of total nitrogen from the leachate while recovering about 51% of the influent ammonia in the catholyte, in comparison to 38.1 +- 4.4% of total nitrogen removal by the control reactor.	Nitrogen	184-192	G protein-coupled estrogen receptor 1	Homo sapiens	4-7
31872599-0	2019	[Molecular mechanism of apoptosis of breast cancer SKBR-3 cells induced by cryptanshinone via G protein coupled estrogen receptor( GPER) mediated pathway].	cryptanshinone	75-89	G protein-coupled estrogen receptor 1	Homo sapiens	131-135
31872599-0	2019	[Molecular mechanism of apoptosis of breast cancer SKBR-3 cells induced by cryptanshinone via G protein coupled estrogen receptor( GPER) mediated pathway].	Estrogens	112-120	G protein-coupled estrogen receptor 1	Homo sapiens	131-135
31872599-1	2019	The study aimed to illuminate the role of G protein coupled estrogen receptor( GPER) and its mediated PI3 K/AKT signaling pathway in cryptotanshinone( CPT) induced apoptosis of breast cancer SKBR-3 cells,which is GPER positive and ER negative.The apoptosis rate of SKBR-3 cells was tested by Annexin V-FITC/PI staining and apoptosis effector caspase-3 was determined by Western blot.	Estrogens	60-68	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
31872599-1	2019	The study aimed to illuminate the role of G protein coupled estrogen receptor( GPER) and its mediated PI3 K/AKT signaling pathway in cryptotanshinone( CPT) induced apoptosis of breast cancer SKBR-3 cells,which is GPER positive and ER negative.The apoptosis rate of SKBR-3 cells was tested by Annexin V-FITC/PI staining and apoptosis effector caspase-3 was determined by Western blot.	cryptotanshinone	133-149	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
31872599-1	2019	The study aimed to illuminate the role of G protein coupled estrogen receptor( GPER) and its mediated PI3 K/AKT signaling pathway in cryptotanshinone( CPT) induced apoptosis of breast cancer SKBR-3 cells,which is GPER positive and ER negative.The apoptosis rate of SKBR-3 cells was tested by Annexin V-FITC/PI staining and apoptosis effector caspase-3 was determined by Western blot.	cryptotanshinone	133-149	G protein-coupled estrogen receptor 1	Homo sapiens	213-217
31872599-1	2019	The study aimed to illuminate the role of G protein coupled estrogen receptor( GPER) and its mediated PI3 K/AKT signaling pathway in cryptotanshinone( CPT) induced apoptosis of breast cancer SKBR-3 cells,which is GPER positive and ER negative.The apoptosis rate of SKBR-3 cells was tested by Annexin V-FITC/PI staining and apoptosis effector caspase-3 was determined by Western blot.	1,3-dimethyl-8-cyclopentylxanthine	151-154	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
31872599-1	2019	The study aimed to illuminate the role of G protein coupled estrogen receptor( GPER) and its mediated PI3 K/AKT signaling pathway in cryptotanshinone( CPT) induced apoptosis of breast cancer SKBR-3 cells,which is GPER positive and ER negative.The apoptosis rate of SKBR-3 cells was tested by Annexin V-FITC/PI staining and apoptosis effector caspase-3 was determined by Western blot.	1,3-dimethyl-8-cyclopentylxanthine	151-154	G protein-coupled estrogen receptor 1	Homo sapiens	213-217
31872599-16	2019	Furthermore,CPT could downregulate GPER expression in SKBR-3 cells( P&lt;0.	1,3-dimethyl-8-cyclopentylxanthine	12-15	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
31737560-0	2019	Chronic BDE-47 Exposure Aggravates Malignant Phenotypes and Chemoresistance by Activating ERK Through ERalpha and GPR30 in Endometrial Carcinoma.	2,2',4,4'-tetrabromodiphenyl ether	8-14	G protein-coupled estrogen receptor 1	Homo sapiens	114-119
31737560-4	2019	Mechanisms of estrogen receptor alpha (ERalpha) and G-protein-coupled receptor-30 (GPR30) involved in BDE-47 carcinogenesis are yet to be identified.	2,2',4,4'-tetrabromodiphenyl ether	102-108	G protein-coupled estrogen receptor 1	Homo sapiens	52-81
31737560-4	2019	Mechanisms of estrogen receptor alpha (ERalpha) and G-protein-coupled receptor-30 (GPR30) involved in BDE-47 carcinogenesis are yet to be identified.	2,2',4,4'-tetrabromodiphenyl ether	102-108	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
31737560-10	2019	Knockdown of ERalpha or GPR30 by small interfering RNA reversed the stimulating effect of BDE-47 on cell growth, migration and invasion of EC cells.	2,2',4,4'-tetrabromodiphenyl ether	90-96	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
31737560-12	2019	Overall, our results indicate that chronic BDE-47 exposure triggers phenotypic plasticity, promotes progression and even chemoresistance in EC cells, at least in part, via ERalpha/GPR30 and EGFR/ERK signaling pathways.	2,2',4,4'-tetrabromodiphenyl ether	43-49	G protein-coupled estrogen receptor 1	Homo sapiens	180-185
31872599-17	2019	01),which could be inhibited by G1 and enhanced by G15.In conclusion,CPT could induce the apoptosis of ER negative and GPER positive breast cancer SKBR-3 cells and the molecular mechanism is related to its regulatory effect of GPER and its mediated PI3 K/AKT signaling pathway.	1,3-dimethyl-8-cyclopentylxanthine	69-72	G protein-coupled estrogen receptor 1	Homo sapiens	119-123
31872599-17	2019	01),which could be inhibited by G1 and enhanced by G15.In conclusion,CPT could induce the apoptosis of ER negative and GPER positive breast cancer SKBR-3 cells and the molecular mechanism is related to its regulatory effect of GPER and its mediated PI3 K/AKT signaling pathway.	1,3-dimethyl-8-cyclopentylxanthine	69-72	G protein-coupled estrogen receptor 1	Homo sapiens	227-231
31696058-1	2019	Expression patterns of estrogen receptors [ERalpha, ERbeta, and G-protein associated ER (GPER)] in melanoma and skin may suggest their differential roles in carcinogenesis.	Estrogens	23-31	G protein-coupled estrogen receptor 1	Homo sapiens	64-87
31708873-1	2019	The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain receptor that mediates non-genomic estrogen related signaling.	Estrogens	22-30	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
31708873-4	2019	Therefore, a better understanding of the role GPER plays in cancer biology may lead to the identification of novel therapeutic targets, especially among estrogen-related cancers.	Estrogens	153-161	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
31696058-1	2019	Expression patterns of estrogen receptors [ERalpha, ERbeta, and G-protein associated ER (GPER)] in melanoma and skin may suggest their differential roles in carcinogenesis.	Estrogens	23-31	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
31545891-0	2019	Activation of G-Protein-Coupled Receptor 30 Protects Neurons against Excitotoxicity through Inhibiting Excessive Autophagy Induced by Glutamate.	Glutamic Acid	134-143	G protein-coupled estrogen receptor 1	Homo sapiens	14-43
31545891-4	2019	Activation of G-protein-coupled receptor 30 (GPR30), an estrogen membrane receptor, protects neurons from excitotoxicity-induced cell death.	Estrogens	56-64	G protein-coupled estrogen receptor 1	Homo sapiens	14-43
31545891-4	2019	Activation of G-protein-coupled receptor 30 (GPR30), an estrogen membrane receptor, protects neurons from excitotoxicity-induced cell death.	Estrogens	56-64	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
31545891-7	2019	Pretreatment of G1 (GPR30 specific agonist) reduced neuronal loss through inhibiting excessive autophagy induced by glutamate exposure, which was blocked by GPR30 antagonist G15, phosphatidylinositol-3-kinase (PI3K), and the mammalian target of rapamycin (mTOR) inhibitors.	Glutamic Acid	116-125	G protein-coupled estrogen receptor 1	Homo sapiens	20-25
31545891-7	2019	Pretreatment of G1 (GPR30 specific agonist) reduced neuronal loss through inhibiting excessive autophagy induced by glutamate exposure, which was blocked by GPR30 antagonist G15, phosphatidylinositol-3-kinase (PI3K), and the mammalian target of rapamycin (mTOR) inhibitors.	Glutamic Acid	116-125	G protein-coupled estrogen receptor 1	Homo sapiens	157-162
31545891-10	2019	We conclude that GPR30 activation reduces glutamate-induced excessive autophagy in neurons and protects neurons against excitotoxicity.	Glutamic Acid	42-51	G protein-coupled estrogen receptor 1	Homo sapiens	17-22
31242463-0	2019	Glucose-dependent GPER1 expression modulates tamoxifen-induced IGFBP-1 accumulation.	Glucose	0-7	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
31749762-8	2019	Last two decades has witnessed the discovery of alternate forms of ER-alpha, as well as other receptors for estrogen such as ERRgamma, GPER-1 as well as ER-beta, which are activated not only by estrogen, but also by the therapeutic agents such as tamoxifen that are routinely used in treatment of breast cancer.	Estrogens	108-116	G protein-coupled estrogen receptor 1	Homo sapiens	135-141
31468104-0	2019	A nongenomic mechanism for "metalloestrogenic" effects of cadmium in human uterine leiomyoma cells through G protein-coupled estrogen receptor.	Cadmium	58-65	G protein-coupled estrogen receptor 1	Homo sapiens	107-142
31468104-10	2019	Overall, Cd-induced proliferation of human fibroid cells was through a nongenomic GPER/p-src/EGFR/MAPK signaling pathway that did not directly involve ERalpha36.	Cadmium	9-11	G protein-coupled estrogen receptor 1	Homo sapiens	82-86
31370872-0	2019	AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs).	Methylcholanthrene	56-76	G protein-coupled estrogen receptor 1	Homo sapiens	8-12
31370872-11	2019	RESULTS: We first ascertained by docking simulations the ability of 3MC to interact with GPER.	Methylcholanthrene	68-71	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
31370872-12	2019	Thereafter, we established that 3MC activates the EGFR/ERK/c-Fos transduction signaling through both AHR and GPER in SkBr3 cells and CAFs.	Methylcholanthrene	32-35	G protein-coupled estrogen receptor 1	Homo sapiens	109-113
31370872-14	2019	CONCLUSIONS: In the present study we have provided novel insights regarding the molecular mechanisms by which 3MC may trigger a physical and functional interaction between AHR and GPER, leading to the stimulation of both SkBr3 breast cancer cells and CAFs.	Methylcholanthrene	110-113	G protein-coupled estrogen receptor 1	Homo sapiens	180-184
31370872-15	2019	Altogether, our results indicate that 3MC may engage both GPER and AHR transduction pathways toward breast cancer progression.	Methylcholanthrene	38-41	G protein-coupled estrogen receptor 1	Homo sapiens	58-62
31749762-8	2019	Last two decades has witnessed the discovery of alternate forms of ER-alpha, as well as other receptors for estrogen such as ERRgamma, GPER-1 as well as ER-beta, which are activated not only by estrogen, but also by the therapeutic agents such as tamoxifen that are routinely used in treatment of breast cancer.	Estrogens	194-202	G protein-coupled estrogen receptor 1	Homo sapiens	135-141
31749762-8	2019	Last two decades has witnessed the discovery of alternate forms of ER-alpha, as well as other receptors for estrogen such as ERRgamma, GPER-1 as well as ER-beta, which are activated not only by estrogen, but also by the therapeutic agents such as tamoxifen that are routinely used in treatment of breast cancer.	Tamoxifen	247-256	G protein-coupled estrogen receptor 1	Homo sapiens	135-141
31546660-1	2019	Estrogen receptors (ER) include ER alpha, ER beta and new membrane receptor G protein-coupled receptor 30 (GPR30).	Estrogens	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	107-112
31540491-4	2019	The GPER-specific agonist G1 leads to an inhibition of cell proliferation and an elevated level of intracellular calcium (Ca2+).	Calcium	113-120	G protein-coupled estrogen receptor 1	Homo sapiens	4-8
31175966-12	2019	Overall, we show for the first time that GPER may contribute to the neuroprotective effects of IGF-1 against MPTP/MPP+-induced dopaminergic neuronal injury.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	109-113	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
31175966-12	2019	Overall, we show for the first time that GPER may contribute to the neuroprotective effects of IGF-1 against MPTP/MPP+-induced dopaminergic neuronal injury.	mangion-purified polysaccharide (Candida albicans)	114-118	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
31435166-6	2019	GPER is also involved in cell cycle regulation, endoplasmic reticulum stress, proliferation, apoptosis, vascularization, cell migration, and the regulation of fatty acid and estrogen metabolism in CRC cells.	Fatty Acids	159-169	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
31242463-8	2019	To determine if [D-glucose]-dependent GPER1 accumulation altered breast cancer cell response to tamoxifen, cells grown in the presence of decreasing [D-glucose] were co-treated with tamoxifen and IGFBP-1 transcription was measured.	Tamoxifen	96-105	G protein-coupled estrogen receptor 1	Homo sapiens	38-43
31242463-8	2019	To determine if [D-glucose]-dependent GPER1 accumulation altered breast cancer cell response to tamoxifen, cells grown in the presence of decreasing [D-glucose] were co-treated with tamoxifen and IGFBP-1 transcription was measured.	Glucose	17-26	G protein-coupled estrogen receptor 1	Homo sapiens	38-43
31242463-9	2019	The results from these experiments reveal that D-glucose deprivation increased GPER1-mediated and tamoxifen-induced IGFBP-1 transcription suggesting that [D-glucose] may increase breast cancer cell sensitivity to tamoxifen.	Glucose	47-56	G protein-coupled estrogen receptor 1	Homo sapiens	79-84
31242463-9	2019	The results from these experiments reveal that D-glucose deprivation increased GPER1-mediated and tamoxifen-induced IGFBP-1 transcription suggesting that [D-glucose] may increase breast cancer cell sensitivity to tamoxifen.	Glucose	155-164	G protein-coupled estrogen receptor 1	Homo sapiens	79-84
31242463-10	2019	Taken together, these results identify a previously unknown mechanism that regulates GPER1 expression that modifies one aspect tamoxifen action in breast cancer cells.	Tamoxifen	127-136	G protein-coupled estrogen receptor 1	Homo sapiens	85-90
31242463-0	2019	Glucose-dependent GPER1 expression modulates tamoxifen-induced IGFBP-1 accumulation.	Tamoxifen	45-54	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
31242463-3	2019	The recently identified GPER1-dependent mechanism of tamoxifen action in breast cancer cells underscores the importance of identifying mechanisms that regulate GPER1 expression in this cell type.	Tamoxifen	53-62	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
31242463-3	2019	The recently identified GPER1-dependent mechanism of tamoxifen action in breast cancer cells underscores the importance of identifying mechanisms that regulate GPER1 expression in this cell type.	Tamoxifen	53-62	G protein-coupled estrogen receptor 1	Homo sapiens	160-165
31242463-4	2019	We hypothesized that GPER1 expression in breast cancer cells is sensitive to [D-glucose] and provide data showing increased GPER1 expression when cells were cultured in low [D-glucose].	Glucose	78-87	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
31242463-4	2019	We hypothesized that GPER1 expression in breast cancer cells is sensitive to [D-glucose] and provide data showing increased GPER1 expression when cells were cultured in low [D-glucose].	Glucose	174-183	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
31242463-4	2019	We hypothesized that GPER1 expression in breast cancer cells is sensitive to [D-glucose] and provide data showing increased GPER1 expression when cells were cultured in low [D-glucose].	Glucose	174-183	G protein-coupled estrogen receptor 1	Homo sapiens	124-129
31242463-8	2019	To determine if [D-glucose]-dependent GPER1 accumulation altered breast cancer cell response to tamoxifen, cells grown in the presence of decreasing [D-glucose] were co-treated with tamoxifen and IGFBP-1 transcription was measured.	Glucose	19-26	G protein-coupled estrogen receptor 1	Homo sapiens	38-43
31016847-0	2019	Bisphenol A promotes the proliferation of leiomyoma cells by GPR30-EGFR signaling pathway.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
31082617-0	2019	GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.	Ceramides	96-104	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
31082617-7	2019	However, GPER1 overexpressing cells were less sensitive against doxorubicin as compared to control cells.	Doxorubicin	64-75	G protein-coupled estrogen receptor 1	Homo sapiens	9-14
31082617-8	2019	In previous work we showed the effect of transient GPER1 overexpression on the synthesis of several ceramide synthases (CerS) thereby influencing the sphingolipid pathway.	Sphingolipids	150-162	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
31016847-1	2019	AIM: To study the molecular mechanism of G protein-coupled receptor 30-epidermal growth factor receptor (GPR30-EGFR) signaling pathway on the proliferation of leiomyoma cells exposed with bisphenol A.	bisphenol A	188-199	G protein-coupled estrogen receptor 1	Homo sapiens	105-110
31016847-5	2019	RESULTS: Bisphenol A promoted the growth of UL cells and the expressions of GPR30, EGFR, c-fos and p-ERK1/2.	bis(4-hydroxyphenyl)sulfone	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
30919959-0	2019	Raloxifene decreases cell viability and migratory potential in prostate cancer cells (LNCaP) with GPR30/GPER1 involvement.	Raloxifene Hydrochloride	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	98-103
31016847-6	2019	CONCLUSION: Bisphenol A was found to be a promoter specifically to proliferate the human UL cells by activating the transcription and translation of GPR30-EGFR and MAPK/ERK/c-fos signaling pathway members.	bisphenol A	12-23	G protein-coupled estrogen receptor 1	Homo sapiens	149-154
30919959-0	2019	Raloxifene decreases cell viability and migratory potential in prostate cancer cells (LNCaP) with GPR30/GPER1 involvement.	Raloxifene Hydrochloride	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	104-109
30919959-8	2019	CONCLUSIONS: Raloxifene was able to modulate GPER1 in LNCaP prostate tumour cells, decreasing cell viability and their migratory potential.	Raloxifene Hydrochloride	13-23	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
30645008-3	2019	Tamoxifen (TAM), widely used in chemotherapy of ERalpha-positive breast cancer, is considered as an ERalpha antagonist and GPER agonist.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	123-127
30919959-1	2019	OBJECTIVES: This study evaluated raloxifene (ral) effects on LNCaP prostate tumour cells modulating the activity of GPER1/GPR30 receptors.	Raloxifene Hydrochloride	33-43	G protein-coupled estrogen receptor 1	Homo sapiens	116-121
30919959-1	2019	OBJECTIVES: This study evaluated raloxifene (ral) effects on LNCaP prostate tumour cells modulating the activity of GPER1/GPR30 receptors.	Raloxifene Hydrochloride	33-43	G protein-coupled estrogen receptor 1	Homo sapiens	122-127
30645008-3	2019	Tamoxifen (TAM), widely used in chemotherapy of ERalpha-positive breast cancer, is considered as an ERalpha antagonist and GPER agonist.	Tamoxifen	11-14	G protein-coupled estrogen receptor 1	Homo sapiens	123-127
30645008-8	2019	Additionally, TAM induced autophagy in a GPER-dependent manner.	Tamoxifen	14-17	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
30851383-0	2019	Structural and energetic basis for novel epicatechin derivatives acting as GPER agonists through the MMGBSA method.	Catechin	41-52	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	0-15	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Catechin	4-7	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
30851383-1	2019	(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway.	Nitric Oxide	93-105	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	Catechin	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-prop	87-95	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-prop	87-95	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-prop	87-95	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-4-prop	97-107	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-4-prop	97-107	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-4-prop	97-107	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-5-prop	112-122	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-5-prop	112-122	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-2	2019	Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site.	epi-5-prop	112-122	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
30851383-4	2019	In this contribution, we explore the structural and energetic changes coupling the binding of Epi and its four derivatives to GPER.	Catechin	94-97	G protein-coupled estrogen receptor 1	Homo sapiens	126-130
30851383-7	2019	Structural analysis demonstrated that Epi, Epi-4-prop and Epi-5-prop share more similar interactions at GPER binding sites with similar conformational behavior than with Epi-prop and Epi-Ms.	Catechin	38-41	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
30851383-7	2019	Structural analysis demonstrated that Epi, Epi-4-prop and Epi-5-prop share more similar interactions at GPER binding sites with similar conformational behavior than with Epi-prop and Epi-Ms.	epi-4-prop	43-53	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
30851383-7	2019	Structural analysis demonstrated that Epi, Epi-4-prop and Epi-5-prop share more similar interactions at GPER binding sites with similar conformational behavior than with Epi-prop and Epi-Ms.	epi-5-prop	58-68	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
31040364-0	2019	Targeting GPER1 to suppress autophagy as a male-specific therapeutic strategy for iron-induced striatal injury.	Iron	82-86	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
30879772-0	2019	Estradiol stimulates cell proliferation via classic estrogen receptor-alpha and G protein-coupled estrogen receptor-1 in human renal tubular epithelial cell primary cultures.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	80-117
30879772-3	2019	Incubation of HRTEC with the G protein-coupled estrogen receptor 1 (GPER-1) agonist G-1 increased BrdU uptake.	Bromodeoxyuridine	98-102	G protein-coupled estrogen receptor 1	Homo sapiens	29-66
30879772-3	2019	Incubation of HRTEC with the G protein-coupled estrogen receptor 1 (GPER-1) agonist G-1 increased BrdU uptake.	Bromodeoxyuridine	98-102	G protein-coupled estrogen receptor 1	Homo sapiens	68-74
30879772-5	2019	Treatment of HRTEC with the GPER-1 antagonist G-15, the ER inhibitor ICI182,780, or the beta-catenin inhibitor iCRT14, completely abrogated the increase in BrdU uptake induced by 17betaE.	hrtec	13-18	G protein-coupled estrogen receptor 1	Homo sapiens	28-34
30879772-7	2019	In conclusion, estradiol stimulates cell proliferation in HRTEC primary cultures through both ERalpha and GPER-1 estrogen receptors and involves beta-catenin activation.	Estradiol	15-24	G protein-coupled estrogen receptor 1	Homo sapiens	106-112
31040364-8	2019	This finding opens the prospect of a male-specific therapeutic strategy targeting GPER1 for autophagy suppression in patients suffering from iron overload after hemorrhage.	Iron	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	82-87
30677511-0	2019	Involvement of estrogen receptor and GPER in bisphenol A induced proliferation of vascular smooth muscle cells.	bisphenol A	45-56	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
30570746-9	2019	In this study, we also demonstrate that selective activation of GPER induced astrocyte apoptosis via the phospholipase C pathway and subsequent intracellular calcium rise, whereas in neurons, this effect was not observed.	Calcium	158-165	G protein-coupled estrogen receptor 1	Homo sapiens	64-68
31028714-2	2019	MATERIAL AND METHODS Expression of GPER mRNA in gastric cancer tissues and normal adjacent tissues was investigated using data from The Cancer Genome Atlas (TCGA), the Gene Expression Omnibus (GEO), and Oncomine database.	oncomine	203-211	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
31028714-6	2019	Immunohistochemistry and Western blot evaluated GPER protein expression in tissue microarrays (TMAs) and gastric cancer cell lines.	tmas	95-99	G protein-coupled estrogen receptor 1	Homo sapiens	48-52
30575816-0	2019	Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	66-101
30575816-2	2019	Tamoxifen is also an agonist of the G protein-coupled estrogen receptor (GPER), a GPCR ubiquitously expressed in tissues that mediates the acute response to estrogens.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	36-71
30575816-2	2019	Tamoxifen is also an agonist of the G protein-coupled estrogen receptor (GPER), a GPCR ubiquitously expressed in tissues that mediates the acute response to estrogens.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	73-77
30961827-2	2019	Differentiation of pancreatic stellate cells (PSCs) into myofibroblasts is inhibited by the estrogen-receptor modulator, tamoxifen, which activates a G-protein-coupled receptor (GPCR) for estrogen (GPER).	Tamoxifen	121-130	G protein-coupled estrogen receptor 1	Homo sapiens	198-202
30677511-9	2019	Blocking the functions of ERalpha and GPER by their specific inhibitors can attenuate the BPA induced proliferation of VSMCs and expression of Ang II.	bisphenol A	90-93	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
30677511-10	2019	Consistently, BPA induced expression of TNFalpha and IL-6 was also attenuated by inhibitors of ERalpha and GPER.	bisphenol A	14-17	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
30677511-11	2019	BPA can increase the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) though GPER.	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
30677511-13	2019	Collectively, our present study suggested that BPA can trigger the proliferation of VSMCs via both ERalpha and GPER dependent manners.	bisphenol A	47-50	G protein-coupled estrogen receptor 1	Homo sapiens	111-115
30451119-0	2019	Synthesis and In Vitro Evaluation of Tetrahydroquinoline Derivatives as Antiproliferative Compounds of Breast Cancer via Targeting the GPER.	1,2,3,4-tetrahydroquinoline	37-56	G protein-coupled estrogen receptor 1	Homo sapiens	135-139
30889865-5	2019	We propose a novel hypothesis that ER-alpha36-GPER signaling initially induces rapid and temporal activation of NADPH oxidase 1 to generate superoxide, which subsequently activates redox-sensitive neutral sphingomyelinase 2 generating the lipid signaling mediator ceramide.	Superoxides	140-150	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
30889865-5	2019	We propose a novel hypothesis that ER-alpha36-GPER signaling initially induces rapid and temporal activation of NADPH oxidase 1 to generate superoxide, which subsequently activates redox-sensitive neutral sphingomyelinase 2 generating the lipid signaling mediator ceramide.	Ceramides	264-272	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
30590021-6	2019	Furthermore, GPR30 antagonist pre-treatment inhibited increases in NETosis and PAD4 expression mediated by G-1 and partially inhibited these effects mediated by E2.	Estradiol	161-163	G protein-coupled estrogen receptor 1	Homo sapiens	13-18
30590021-7	2019	These results demonstrate that E2 treatment induces NETosis via not only ERalpha/ERbeta but also GPR30 in neutrophil-like HL-60 cells.	Estradiol	31-33	G protein-coupled estrogen receptor 1	Homo sapiens	97-102
28877783-5	2019	The effects of activating GPER and function of G15 were analyzed in the proliferation of A549 and H1793 cell lines and development of urethane-induced adenocarcinoma.	Urethane	134-142	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
30478785-0	2019	G-protein-coupled estrogen receptor GPER-1 expression in hormone receptor-positive breast cancer is associated with poor benefit of tamoxifen.	Tamoxifen	132-141	G protein-coupled estrogen receptor 1	Homo sapiens	36-42
30478785-1	2019	BACKGROUND: The role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly controversial issue.	Tamoxifen	93-102	G protein-coupled estrogen receptor 1	Homo sapiens	24-61
30478785-1	2019	BACKGROUND: The role of G-protein-coupled estrogen receptor 1 (GPER-1) in the development of tamoxifen resistance in breast cancer is a highly controversial issue.	Tamoxifen	93-102	G protein-coupled estrogen receptor 1	Homo sapiens	63-69
30478785-10	2019	DFS between tamoxifen- and aromatase inhibitor-treated GPER-1-positive patients was similar (p = 0.090).	Tamoxifen	12-21	G protein-coupled estrogen receptor 1	Homo sapiens	55-61
30478785-11	2019	Notably, after matching the analysis for the most important prognostic factors, DFS for tamoxifen-treated GPER-1-positive patients was 69.1%, which is a percentage that is significantly lower compared to DFS for GPER-1-positive patients treated with aromatase inhibitors (92.7%) (p = 0.005).	Tamoxifen	88-97	G protein-coupled estrogen receptor 1	Homo sapiens	106-112
30478785-11	2019	Notably, after matching the analysis for the most important prognostic factors, DFS for tamoxifen-treated GPER-1-positive patients was 69.1%, which is a percentage that is significantly lower compared to DFS for GPER-1-positive patients treated with aromatase inhibitors (92.7%) (p = 0.005).	Tamoxifen	88-97	G protein-coupled estrogen receptor 1	Homo sapiens	212-218
30678825-13	2019	The interaction with DOX appears to be cell type dependent, exhibiting a non-monotonic response curve in MRC-5 cells, a GPER expressing cell line.	Doxorubicin	21-24	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
30866584-2	2019	By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17beta-estradiol (E2) and the G protein estrogen receptor (GPER) agonist G-1 induce the up-regulation and secretion of FGF2 via GPER together with the EGFR/ERK/c-fos/AP-1 signaling cascade in (ER)-negative primary CAFs.	Estradiol	115-131	G protein-coupled estrogen receptor 1	Homo sapiens	243-247
30760632-0	2019	Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity.	Nitrogen	39-40	G protein-coupled estrogen receptor 1	Homo sapiens	6-35
30760632-0	2019	Human G protein-coupled receptor 30 is N-glycosylated and N-terminal domain asparagine 44 is required for receptor structure and activity.	Asparagine	76-86	G protein-coupled estrogen receptor 1	Homo sapiens	6-35
30760632-4	2019	Here, we used human embryonic kidney (HEK) 293 (HEK293) cells ectopically expressing N-terminally FLAG-tagged human GPR30 and three unique antibodies (Ab) specifically targetting the receptor N-terminal domain (N-domain) to investigate the role of N-glycosylation in receptor maturation and activity, the latter assayed by constitutive receptor-stimulated extracellular-regulated protein kinase (ERK) 1/2 (ERK1/2) activity.	Nitrogen	85-86	G protein-coupled estrogen receptor 1	Homo sapiens	116-121
30646517-1	2019	The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERalpha, and ERbeta, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERalpha positive breast cancer.	Tamoxifen	280-289	G protein-coupled estrogen receptor 1	Homo sapiens	4-39
30646517-1	2019	The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERalpha, and ERbeta, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERalpha positive breast cancer.	Tamoxifen	280-289	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
30848227-4	2019	BPA exerts other effects by activating the membrane receptor GPER (GPR30) and/or other receptors such as the estrogen-related receptors (ERRs).	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	61-65
30848227-4	2019	BPA exerts other effects by activating the membrane receptor GPER (GPR30) and/or other receptors such as the estrogen-related receptors (ERRs).	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	67-72
29883692-0	2018	17beta-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	60-95
30538116-3	2019	Here we report that tamoxifen regulates the level and activity of collagen cross-linking and degradative enzymes, and hence the organization of the extracellular matrix, via a mechanism involving both the G protein-coupled estrogen receptor (GPER) and hypoxia-inducible factor-1 alpha (HIF-1A).	Tamoxifen	20-29	G protein-coupled estrogen receptor 1	Homo sapiens	205-240
30538116-3	2019	Here we report that tamoxifen regulates the level and activity of collagen cross-linking and degradative enzymes, and hence the organization of the extracellular matrix, via a mechanism involving both the G protein-coupled estrogen receptor (GPER) and hypoxia-inducible factor-1 alpha (HIF-1A).	Tamoxifen	20-29	G protein-coupled estrogen receptor 1	Homo sapiens	242-246
30267584-6	2018	The interaction between miR-103 and G protein-coupled estrogen receptor 1 (GPER1) was confirmed with the dual luciferase assays.	mir-103	24-31	G protein-coupled estrogen receptor 1	Homo sapiens	36-73
30267584-6	2018	The interaction between miR-103 and G protein-coupled estrogen receptor 1 (GPER1) was confirmed with the dual luciferase assays.	mir-103	24-31	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
30538116-6	2019	Our findings implicate the GPER/HIF-1A axis as a master regulator of peri-tumoral stromal remodeling and the fibrovascular tumor microenvironment and offer a paradigm shift for tamoxifen from a well-established drug in breast cancer hormonal therapy to an alternative candidate for stromal targeting strategies in PDAC and possibly other cancers.	Tamoxifen	177-186	G protein-coupled estrogen receptor 1	Homo sapiens	27-31
30538117-2	2019	Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat estrogen-positive breast cancer.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	29-64
30538117-2	2019	Tamoxifen, an agonist of the G protein-coupled estrogen receptor (GPER), is widely used to treat estrogen-positive breast cancer.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
30538117-3	2019	Here, we show that tamoxifen mechanically reprograms the tumor microenvironment through a newly identified GPER-mediated mechanism.	Tamoxifen	19-28	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
30538117-4	2019	Tamoxifen inhibits the myofibroblastic differentiation of pancreatic stellate cells (PSCs) in the tumor microenvironment of pancreatic cancer in an acto-myosin-dependent manner via RhoA-mediated contractility, YAP deactivation, and GPER signaling.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	232-236
29428396-3	2018	BPA has a weak affinity for ERalpha/beta but interaction with extranuclearly located pathways activated by estrogens such as ERRgamma and GPER reveals how BPA can act at low doses.	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	138-142
29428396-3	2018	BPA has a weak affinity for ERalpha/beta but interaction with extranuclearly located pathways activated by estrogens such as ERRgamma and GPER reveals how BPA can act at low doses.	bisphenol A	155-158	G protein-coupled estrogen receptor 1	Homo sapiens	138-142
30048677-5	2018	Some of BPA"s effects are reversed by oestrogen and/or GPER inhibitors.	bisphenol A	8-11	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
29883692-3	2018	The G protein-coupled estrogen receptor (GPER) is known to facilitate rapid actions of 17beta-estradiol, though its role in modulation of ion channels is not widely explored.	Estradiol	87-103	G protein-coupled estrogen receptor 1	Homo sapiens	4-39
29883692-3	2018	The G protein-coupled estrogen receptor (GPER) is known to facilitate rapid actions of 17beta-estradiol, though its role in modulation of ion channels is not widely explored.	Estradiol	87-103	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
29883692-5	2018	In the present study, using single channel cell-attached patch clamp electrophysiology in HEK293 cells, we show that 17beta-estradiol increases the activity of hTREK1 channel by acting through hGPER and increasing the channel opening probability within minutes.	Estradiol	117-133	G protein-coupled estrogen receptor 1	Homo sapiens	193-198
29883692-8	2018	Mutational studies revealed the serines at positions 315 and 348 in the C-terminal domain of hTREK1 to be the target sites for dephosphorylation induced by 17beta-estradiol action through hGPER.	Serine	32-39	G protein-coupled estrogen receptor 1	Homo sapiens	188-193
29883692-8	2018	Mutational studies revealed the serines at positions 315 and 348 in the C-terminal domain of hTREK1 to be the target sites for dephosphorylation induced by 17beta-estradiol action through hGPER.	Estradiol	156-172	G protein-coupled estrogen receptor 1	Homo sapiens	188-193
29883692-9	2018	Elucidation of the pathway for the potentiating action of 17beta-estradiol via hGPER on hTREK1 channel activity will help us understand better one of the many possible neuroprotective mechanisms of 17beta-estradiol and hTREK1 channel.	Estradiol	58-74	G protein-coupled estrogen receptor 1	Homo sapiens	79-84
29883692-9	2018	Elucidation of the pathway for the potentiating action of 17beta-estradiol via hGPER on hTREK1 channel activity will help us understand better one of the many possible neuroprotective mechanisms of 17beta-estradiol and hTREK1 channel.	Estradiol	198-214	G protein-coupled estrogen receptor 1	Homo sapiens	79-84
30258538-0	2018	A Series of Indole-Thiazole Derivatives Act as GPER Agonists and Inhibit Breast Cancer Cell Growth.	indole-thiazole	12-27	G protein-coupled estrogen receptor 1	Homo sapiens	47-51
29373840-4	2018	Here, we demonstrated that icariin, which is a G protein-coupled estrogen receptor 1 (GPER) agonist, inhibited podocyte apoptosis by reducing ROS, maintaining the integrity of mitochondrial membranes.	icariin	27-34	G protein-coupled estrogen receptor 1	Homo sapiens	47-84
29373840-4	2018	Here, we demonstrated that icariin, which is a G protein-coupled estrogen receptor 1 (GPER) agonist, inhibited podocyte apoptosis by reducing ROS, maintaining the integrity of mitochondrial membranes.	icariin	27-34	G protein-coupled estrogen receptor 1	Homo sapiens	86-90
29373840-4	2018	Here, we demonstrated that icariin, which is a G protein-coupled estrogen receptor 1 (GPER) agonist, inhibited podocyte apoptosis by reducing ROS, maintaining the integrity of mitochondrial membranes.	Reactive Oxygen Species	142-145	G protein-coupled estrogen receptor 1	Homo sapiens	86-90
29964007-4	2018	Rapid non-genomic signaling is initiated from the plasma membrane by a G-protein coupled receptor called GPER1 that binds 17beta-estradiol.	Estradiol	122-138	G protein-coupled estrogen receptor 1	Homo sapiens	105-110
29758456-0	2018	GPER/Hippo-YAP signal is involved in Bisphenol S induced migration of triple negative breast cancer (TNBC) cells.	bis(4-hydroxyphenyl)sulfone	37-46	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
29758456-7	2018	Inhibition of G protein-coupled estrogen receptor 1 (GPER) and its downstream PLCbeta/PKC signals attenuate the effects of BPS-induced YAP dephosphorylation and CTGF up-regulation.	bis(4-hydroxyphenyl)sulfone	123-126	G protein-coupled estrogen receptor 1	Homo sapiens	14-51
29758456-7	2018	Inhibition of G protein-coupled estrogen receptor 1 (GPER) and its downstream PLCbeta/PKC signals attenuate the effects of BPS-induced YAP dephosphorylation and CTGF up-regulation.	bis(4-hydroxyphenyl)sulfone	123-126	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
29758456-8	2018	Targeted inhibition of GPER/YAP inhibits BPS-induced migration of TNBC cells.	bis(4-hydroxyphenyl)sulfone	41-44	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
29758456-9	2018	Collectively, we reveal that GPER/Hippo-YAP signal is involved in BPS-induced migration of TNBC cells.	bis(4-hydroxyphenyl)sulfone	66-69	G protein-coupled estrogen receptor 1	Homo sapiens	29-33
29964007-7	2018	In this review, we describe several notable characteristics of GPER1 such as the ability of several endogenous steroids as well as artificially synthesized molecules to bind the GPER1.	Steroids	111-119	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
29964007-7	2018	In this review, we describe several notable characteristics of GPER1 such as the ability of several endogenous steroids as well as artificially synthesized molecules to bind the GPER1.	Steroids	111-119	G protein-coupled estrogen receptor 1	Homo sapiens	178-183
29807145-6	2018	Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15).	Estradiol	5-7	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
29885598-8	2018	Finally, deletion of GPR30 in beta-cells or islets ablated genistein-induced CREB phosphorylation and its cytoprotective effect.	Genistein	59-68	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
29885598-9	2018	These findings demonstrate that genistein is a survival factor for beta-cells via GPR30-initiated, Galphas-mediated activation of CREB.	galphas	99-106	G protein-coupled estrogen receptor 1	Homo sapiens	82-87
30050469-0	2018	Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	47-52
30050469-6	2018	Evidence that tamoxifen functions as a GPR30 (G-Protein Coupled Receptor 30) agonist activating adenylyl cyclase and EGFR (Epidermal Growth Factor Receptor) intracellular signaling networks, provides yet another means of explaining the multi-functionality of tamoxifen.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	39-44
30050469-6	2018	Evidence that tamoxifen functions as a GPR30 (G-Protein Coupled Receptor 30) agonist activating adenylyl cyclase and EGFR (Epidermal Growth Factor Receptor) intracellular signaling networks, provides yet another means of explaining the multi-functionality of tamoxifen.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	46-75
30050469-6	2018	Evidence that tamoxifen functions as a GPR30 (G-Protein Coupled Receptor 30) agonist activating adenylyl cyclase and EGFR (Epidermal Growth Factor Receptor) intracellular signaling networks, provides yet another means of explaining the multi-functionality of tamoxifen.	Tamoxifen	259-268	G protein-coupled estrogen receptor 1	Homo sapiens	39-44
30050469-6	2018	Evidence that tamoxifen functions as a GPR30 (G-Protein Coupled Receptor 30) agonist activating adenylyl cyclase and EGFR (Epidermal Growth Factor Receptor) intracellular signaling networks, provides yet another means of explaining the multi-functionality of tamoxifen.	Tamoxifen	259-268	G protein-coupled estrogen receptor 1	Homo sapiens	46-75
30050469-7	2018	Here ordinary differential equation (ODE) modeling, RNA sequencing and real time qPCR analysis were utilized to establish the necessary data for gene network mapping of tamoxifen-stimulated MCF-7 cells, which express the endogenous ER and GPR30.	Tamoxifen	169-178	G protein-coupled estrogen receptor 1	Homo sapiens	239-244
29807145-6	2018	Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15).	Estradiol	5-7	G protein-coupled estrogen receptor 1	Homo sapiens	223-228
29807145-6	2018	Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15).	Estradiol	9-25	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
29807145-6	2018	Both E2 (17beta-estradiol) and Ral increased the expression of ERalpha and GPR30 and enhanced TDP-25 cell viability, and these effects were completely abolished by treatment with an ERalpha/beta antagonist (ICI 182,780) or GPR30 antagonist (G15).	Estradiol	9-25	G protein-coupled estrogen receptor 1	Homo sapiens	223-228
29805678-6	2018	Expression of GPER and activation of c-src and epidermal growth factor receptor (EGFR) by 17beta-estradiol was analyzed by western blotting.	Estradiol	90-106	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
29275510-3	2018	In our previous study with cultured human fetal lung fibroblasts (HFLF), we demonstrated that 24-h exposure to 1 and 100 microM BPA increased GPR30 protein in the nuclear fraction.	bisphenol A	128-131	G protein-coupled estrogen receptor 1	Homo sapiens	142-147
29608013-0	2018	17beta-Estradiol on the Expression of G-Protein Coupled Estrogen Receptor (GPER/GPR30) Mitophagy, and the PI3K/Akt Signaling Pathway in ATDC5 Chondrocytes In Vitro.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	80-85
29608013-2	2018	G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1.	Estradiol	89-105	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
29608013-2	2018	G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1.	Estradiol	89-105	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
29608013-2	2018	G-protein coupled estrogen receptor (GPER/GPR30) activates cell signaling in response to 17beta-estradiol, which can be blocked by the GPR30 agonist, G15, an analog of G-1.	Estradiol	89-105	G protein-coupled estrogen receptor 1	Homo sapiens	135-140
29608013-3	2018	The aims of this study were to investigate the effects of 17beta-estradiol on the expression of G-protein coupled estrogen receptor (GPER/GPR30) on mitophagy and the PI3K/Akt signaling pathway in ATDC5 chondrocytes in vitro.	Estradiol	58-74	G protein-coupled estrogen receptor 1	Homo sapiens	133-137
29608013-3	2018	The aims of this study were to investigate the effects of 17beta-estradiol on the expression of G-protein coupled estrogen receptor (GPER/GPR30) on mitophagy and the PI3K/Akt signaling pathway in ATDC5 chondrocytes in vitro.	Estradiol	58-74	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
29608013-9	2018	RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found.	Estradiol	11-27	G protein-coupled estrogen receptor 1	Homo sapiens	80-84
29608013-9	2018	RESULTS In 17beta-estradiol-treated ATDC5 chondrocytes, increased expression of GPER/GPR30 was found, but fewer mitophagosomes were observed, and decreased numbers of TOM20-positive granules were co-localized with decreased LAMP2 and increased expression levels of TOM20, Hsp60, p-Akt, and p-mTOR, and reduced expression of LC3-II, were found.	Estradiol	11-27	G protein-coupled estrogen receptor 1	Homo sapiens	85-90
29608013-11	2018	CONCLUSIONS Treatment with 17beta-estradiol protected ATDC5 chondrocytes against mitophagy via the GPER/GPR30 and the PI3K/Akt signaling pathway.	Estradiol	27-43	G protein-coupled estrogen receptor 1	Homo sapiens	99-103
29608013-11	2018	CONCLUSIONS Treatment with 17beta-estradiol protected ATDC5 chondrocytes against mitophagy via the GPER/GPR30 and the PI3K/Akt signaling pathway.	Estradiol	27-43	G protein-coupled estrogen receptor 1	Homo sapiens	104-109
29790728-0	2018	Hydroxylated Polybrominated Diphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein-Coupled Estrogen Receptor Mediated Pathways.	Phenyl Ethers	28-43	G protein-coupled estrogen receptor 1	Homo sapiens	85-120
29790728-3	2018	OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways.	Halogenated Diphenyl Ethers	76-81	G protein-coupled estrogen receptor 1	Homo sapiens	110-145
29790728-3	2018	OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways.	Halogenated Diphenyl Ethers	76-81	G protein-coupled estrogen receptor 1	Homo sapiens	147-151
29790728-3	2018	OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways.	oh-pbdes	86-94	G protein-coupled estrogen receptor 1	Homo sapiens	110-145
29790728-3	2018	OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways.	oh-pbdes	86-94	G protein-coupled estrogen receptor 1	Homo sapiens	147-151
29790728-4	2018	METHODS: The binding affinities of 12 PBDEs and 18 OH-PBDEs with GPER were determined by a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3).	12 pbdes	35-43	G protein-coupled estrogen receptor 1	Homo sapiens	65-69
29790728-4	2018	METHODS: The binding affinities of 12 PBDEs and 18 OH-PBDEs with GPER were determined by a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3).	18 oh-pbdes	48-59	G protein-coupled estrogen receptor 1	Homo sapiens	65-69
29790728-6	2018	Their activities on GPER pathways were investigated by detecting calcium mobilization and cyclic adenosine monophosphate (cAMP) accumulation in SKBR3 cells.	Calcium	65-72	G protein-coupled estrogen receptor 1	Homo sapiens	20-24
29790728-6	2018	Their activities on GPER pathways were investigated by detecting calcium mobilization and cyclic adenosine monophosphate (cAMP) accumulation in SKBR3 cells.	Cyclic AMP	90-120	G protein-coupled estrogen receptor 1	Homo sapiens	20-24
29790728-6	2018	Their activities on GPER pathways were investigated by detecting calcium mobilization and cyclic adenosine monophosphate (cAMP) accumulation in SKBR3 cells.	Cyclic AMP	122-126	G protein-coupled estrogen receptor 1	Homo sapiens	20-24
29790728-8	2018	RESULTS: Our results showed that 11 of the OH-PBDEs but none of the PBDEs bound to GPER directly.	oh-pbdes	43-51	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
29790728-8	2018	RESULTS: Our results showed that 11 of the OH-PBDEs but none of the PBDEs bound to GPER directly.	Halogenated Diphenyl Ethers	46-51	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
29790728-10	2018	Docking results suggested that the hydroxyl group played an essential role in the binding of OH-PBDEs to GPER by forming hydrogen bond interactions.	oh-pbdes	93-101	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
29790728-10	2018	Docking results suggested that the hydroxyl group played an essential role in the binding of OH-PBDEs to GPER by forming hydrogen bond interactions.	Hydrogen	121-129	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
29790728-11	2018	Most of the OH-PBDEs activated subsequent GPER signaling pathways.	oh-pbdes	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
29790728-13	2018	These three OH-PBDEs also promoted SKBR3 cell migration via GPER pathways with LOECs of 0.1-1 muM.	oh-pbdes	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	60-64
29790728-14	2018	CONCLUSION: OH-PBDEs could bind to GPER, activate the subsequent signaling pathways, and promote SKBR3 cell migration via GPER pathways.	oh-pbdes	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
29790728-14	2018	CONCLUSION: OH-PBDEs could bind to GPER, activate the subsequent signaling pathways, and promote SKBR3 cell migration via GPER pathways.	oh-pbdes	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	122-126
29790728-15	2018	OH-PBDEs might exert estrogenic effects by a novel nongenomic mechanism involving the activation of GPER at nanomolar concentrations.	oh-pbdes	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
29382535-0	2018	MEHP promotes the proliferation of cervical cancer via GPER mediated activation of Akt.	mono-(2-ethylhexyl)phthalate	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	131-135	G protein-coupled estrogen receptor 1	Homo sapiens	30-65
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	131-135	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	131-135	G protein-coupled estrogen receptor 1	Homo sapiens	207-211
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	227-231	G protein-coupled estrogen receptor 1	Homo sapiens	30-65
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	227-231	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
29382535-6	2018	In addition, the inhibitor of G protein coupled estrogen receptor (GPER), while not estrogen receptor alpha (ERalpha), can abolish MEHP induced phosphorylation of Akt and cell proliferation, suggesting that GPER is involved in MEHP induced activation of Akt.	mono-(2-ethylhexyl)phthalate	227-231	G protein-coupled estrogen receptor 1	Homo sapiens	207-211
29608013-0	2018	17beta-Estradiol on the Expression of G-Protein Coupled Estrogen Receptor (GPER/GPR30) Mitophagy, and the PI3K/Akt Signaling Pathway in ATDC5 Chondrocytes In Vitro.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
29360846-7	2018	GPER antagonist, G-36, significantly inhibited both the G-1-induced relaxation effect and G-1-enhanced ET-1 contraction.	G-36	17-21	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
29229551-11	2018	Exemestane also modulates ERK and STAT3 signalling via GPR30.	exemestane	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	55-60
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	56-60
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	145-149
28285016-8	2018	This viewpoint changed recently with the discovery that GPER is associated with aging, particularly that of the cardiovascular system, where the GPER antagonist G36 reduced hypertension and GPER deficiency prevented cardiac fibrosis and vascular dysfunction with age, through the downregulation of Nox1 and as a consequence superoxide production.	Superoxides	324-334	G protein-coupled estrogen receptor 1	Homo sapiens	145-149
28343901-4	2018	However, GPER also has constitutive activity, e.g. in the absence of specific agonists, that was recently shown to promote hypertension and aging-induced tissue damage by promoting Nox1-derived production of ROS.	Reactive Oxygen Species	208-211	G protein-coupled estrogen receptor 1	Homo sapiens	9-13
28343901-5	2018	Furthermore, the small molecule GPER blocker (GRB) G36 reduces blood pressure and vascular ROS production by selectively down-regulating Nox1 expression.	Reactive Oxygen Species	91-94	G protein-coupled estrogen receptor 1	Homo sapiens	32-36
28343901-7	2018	Here, we will discuss the paradigm shift from selective GPER activation to ligand-independent, constitutive GPER signaling as a key regulator of Nox-derived oxidative stress, and the surprising identification of GRBs as the first Nox downregulators for the treatment of chronic non-communicable diseases.	nicotine 1-N-oxide	145-148	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
29229551-5	2018	Exemestane, an aromatase inhibitor, has previously shown anti-tumor properties in mesothelioma preclinical models suggesting a role of G protein-coupled receptor 30 (GPR30) in the drug response.	exemestane	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	135-164
29229551-5	2018	Exemestane, an aromatase inhibitor, has previously shown anti-tumor properties in mesothelioma preclinical models suggesting a role of G protein-coupled receptor 30 (GPR30) in the drug response.	exemestane	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	166-171
29360846-15	2018	These data demonstrate that activation of GPER induces relaxation via cAMP as well as contraction via a mechanism involving transactivation of EGFR and the phosphorylation of ERK1/2 in porcine coronary arteries.	Cyclic AMP	70-74	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
29391778-0	2018	Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway.	ipriflavone	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	110-115
28924735-21	2018	Interestingly, Raloxifene-a GPER-activating selective estrogen receptor modulator-has recently been demonstrated to be preventive for cervical cancer relapse in mice.	Raloxifene Hydrochloride	15-25	G protein-coupled estrogen receptor 1	Homo sapiens	28-32
29745344-5	2018	We included a carboxyl group instead of the acetyl group from G1 to form amides with several moieties to increase affinity on GPER1.	Amides	73-79	G protein-coupled estrogen receptor 1	Homo sapiens	126-131
29745344-6	2018	The designed ligands were submitted to ligand-based and structure-based virtual screening to get insights into the binding mechanism of the best designed compound and phenol red on GPER1.	Phenolsulfonphthalein	167-177	G protein-coupled estrogen receptor 1	Homo sapiens	181-186
29745344-10	2018	The compound showed better IC50 values without phenol red, suggesting that phenol red interfere with the G1-PABA action at GPER1, as observed through in silico studies, which is present in MCF-7 cells according to PCR studies and explains the cell proliferation effects.	Phenolsulfonphthalein	75-85	G protein-coupled estrogen receptor 1	Homo sapiens	123-128
29383185-0	2017	GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway.	ros	76-79	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
30029723-9	2018	Our groups have shown that DHEA and many of its oxidative metabolites serve as a low-affinity ligands for hepatic nuclear receptors, such as the pregnane X receptor, the constitutive androstane receptor, and estrogen receptors alpha/beta (ERalpha/ERbeta) as well as G protein-coupled ER (GPER1).	Dehydroepiandrosterone	27-31	G protein-coupled estrogen receptor 1	Homo sapiens	288-293
30029731-6	2018	We review our recent study showing DHEA activated GPER1 (G-protein-coupled estrogen receptor 1) in HepG2 cells to stimulate miR-21 transcription.	Dehydroepiandrosterone	35-39	G protein-coupled estrogen receptor 1	Homo sapiens	50-55
30029731-6	2018	We review our recent study showing DHEA activated GPER1 (G-protein-coupled estrogen receptor 1) in HepG2 cells to stimulate miR-21 transcription.	Dehydroepiandrosterone	35-39	G protein-coupled estrogen receptor 1	Homo sapiens	57-94
29298702-0	2017	Correction to: Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	15-24	G protein-coupled estrogen receptor 1	Homo sapiens	104-109
28811233-7	2017	The stimulatory effects of TBBPA and BPA on cell proliferation were reversed by pre-treatment with a G protein-coupled receptor 30 (GPR30) antagonist in both cell lines, which possess similar basal GPR30 expression levels.	tetrabromobisphenol A	27-32	G protein-coupled estrogen receptor 1	Homo sapiens	101-130
28945888-13	2017	Conclusion: Human CRC favors estradiol synthesis to augment proliferation via GPER stimulation.	Estradiol	29-38	G protein-coupled estrogen receptor 1	Homo sapiens	78-82
28811233-7	2017	The stimulatory effects of TBBPA and BPA on cell proliferation were reversed by pre-treatment with a G protein-coupled receptor 30 (GPR30) antagonist in both cell lines, which possess similar basal GPR30 expression levels.	tetrabromobisphenol A	27-32	G protein-coupled estrogen receptor 1	Homo sapiens	132-137
28811233-7	2017	The stimulatory effects of TBBPA and BPA on cell proliferation were reversed by pre-treatment with a G protein-coupled receptor 30 (GPR30) antagonist in both cell lines, which possess similar basal GPR30 expression levels.	tetrabromobisphenol A	27-32	G protein-coupled estrogen receptor 1	Homo sapiens	198-203
28811233-7	2017	The stimulatory effects of TBBPA and BPA on cell proliferation were reversed by pre-treatment with a G protein-coupled receptor 30 (GPR30) antagonist in both cell lines, which possess similar basal GPR30 expression levels.	bisphenol A	29-32	G protein-coupled estrogen receptor 1	Homo sapiens	101-130
28811233-7	2017	The stimulatory effects of TBBPA and BPA on cell proliferation were reversed by pre-treatment with a G protein-coupled receptor 30 (GPR30) antagonist in both cell lines, which possess similar basal GPR30 expression levels.	bisphenol A	29-32	G protein-coupled estrogen receptor 1	Homo sapiens	132-137
28811233-8	2017	Taken together, our results show for the first time that TBBPA, which has lower potency than BPA, stimulates ovarian cancer cell proliferation through the GPR30 pathway.	tetrabromobisphenol A	57-62	G protein-coupled estrogen receptor 1	Homo sapiens	155-160
28811233-8	2017	Taken together, our results show for the first time that TBBPA, which has lower potency than BPA, stimulates ovarian cancer cell proliferation through the GPR30 pathway.	bisphenol A	59-62	G protein-coupled estrogen receptor 1	Homo sapiens	155-160
29096683-0	2017	Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	89-94
29192164-0	2017	Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling, impair DNA integrity and reduce cell proliferation in primary PBMC.	bisphenol A	19-30	G protein-coupled estrogen receptor 1	Homo sapiens	57-62
29192164-8	2017	The results further demonstrate that BPA triggered rapidly an ER/GPR30-ERK transduction pathway that leads to decreased telomerase activity in human PBMC.	bisphenol A	37-40	G protein-coupled estrogen receptor 1	Homo sapiens	65-70
29192164-9	2017	This is the first study to demonstrate adverse impact of BPA at levels of current human exposure on telomerase in normal cells, mediated by ER/GPR30-ERK.	bisphenol A	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	143-148
29096683-6	2017	Meanwhile, we show that calycosin stimulated the WDR7-7-GPR30 signaling pathway in MCF-7, T47D, MDA-MB-468, and SKBR3 breast cancer cells.	7,3'-dihydroxy-4'-methoxyisoflavone	24-33	G protein-coupled estrogen receptor 1	Homo sapiens	56-61
29096683-8	2017	Additionally, in all four GPR30-positive breast cancer lines, calycosin decreased the phosphorylation levels of SRC, EGFR, ERK1/2 and Akt, but the inhibition of WDR7-7 blocked these changes and increased proliferation.	7,3'-dihydroxy-4'-methoxyisoflavone	62-71	G protein-coupled estrogen receptor 1	Homo sapiens	26-31
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	56-65	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
29096683-10	2017	CONCLUSIONS: These results suggest the possibility that calycosin inhibited the proliferation of breast cancer cells, at least partially, through WDR7-7-GPR30 signaling, which may explain why calycosin can exert inhibitory effects on ER- breast cancer.	7,3'-dihydroxy-4'-methoxyisoflavone	192-201	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
28882636-8	2017	G-15 reversed the effects of E2 on GPR30 and AKT/mTOR, but did not alter the effect of BPA.	G-15	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	35-40
28935720-10	2017	The effect of GPER activation to inhibit SOCE is not affected by combined nonphosphorylatable substitutions at serines 486 and 668 on STIM1, but is substantially reduced by similar substitutions at serines 575, 608 and 621.	Serine	198-205	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
28902352-5	2017	To understand the mechanism of TAM-resistance in GPER activated ER+ breast cancer, the function of TRIM2 and Bim inducing cell apoptosis was studied.	Tamoxifen	31-34	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
28858478-0	2017	Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway.	bis(4-hydroxyphenyl)sulfone	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	82-117
28858478-0	2017	Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway.	bisphenol B	17-28	G protein-coupled estrogen receptor 1	Homo sapiens	82-117
28858478-0	2017	Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	82-117
28858478-4	2017	Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with bisphenol AF (BPAF) and bisphenol B (BPB) displaying much higher (~9-fold) binding affinity than BPA.	bisphenol A	84-87	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
28858478-4	2017	Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with bisphenol AF (BPAF) and bisphenol B (BPB) displaying much higher (~9-fold) binding affinity than BPA.	4,4'-hexafluorisopropylidene diphenol	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
28858478-4	2017	Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with bisphenol AF (BPAF) and bisphenol B (BPB) displaying much higher (~9-fold) binding affinity than BPA.	bisphenol B	151-162	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
28858478-4	2017	Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with bisphenol AF (BPAF) and bisphenol B (BPB) displaying much higher (~9-fold) binding affinity than BPA.	bisphenol B	164-167	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
28858478-4	2017	Here, using a SKBR3 cell-based fluorescence competitive binding assay, we found six BPA analogues bound to GPER directly, with bisphenol AF (BPAF) and bisphenol B (BPB) displaying much higher (~9-fold) binding affinity than BPA.	bisphenol A	141-144	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
28858478-5	2017	Molecular docking also demonstrated the binding of these BPA analogues to GPER.	bisphenol A	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	74-78
28858478-6	2017	By measuring calcium mobilization and cAMP production in SKBR3 cells, we found the binding of these BPA analogues to GPER lead to the activation of subsequent signaling pathways.	Calcium	13-20	G protein-coupled estrogen receptor 1	Homo sapiens	117-121
28858478-6	2017	By measuring calcium mobilization and cAMP production in SKBR3 cells, we found the binding of these BPA analogues to GPER lead to the activation of subsequent signaling pathways.	Cyclic AMP	38-42	G protein-coupled estrogen receptor 1	Homo sapiens	117-121
28858478-6	2017	By measuring calcium mobilization and cAMP production in SKBR3 cells, we found the binding of these BPA analogues to GPER lead to the activation of subsequent signaling pathways.	bisphenol A	100-103	G protein-coupled estrogen receptor 1	Homo sapiens	117-121
28858478-8	2017	Moreover, based on the results of Boyden chamber and wound-healing assays, BPAF and BPB displayed higher activity in promoting GPER mediated SKBR3 cell migration than BPA with the LOEC of 100 nM.	4,4'-hexafluorisopropylidene diphenol	75-79	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
28858478-8	2017	Moreover, based on the results of Boyden chamber and wound-healing assays, BPAF and BPB displayed higher activity in promoting GPER mediated SKBR3 cell migration than BPA with the LOEC of 100 nM.	bisphenol B	84-87	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
28858478-8	2017	Moreover, based on the results of Boyden chamber and wound-healing assays, BPAF and BPB displayed higher activity in promoting GPER mediated SKBR3 cell migration than BPA with the LOEC of 100 nM.	bisphenol A	75-78	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
28858478-9	2017	Overall, we found two BPA analogues BPAF and BPB could exert higher estrogenic effects than BPA via GPER pathway at nanomolar concentrations.	bisphenol A	22-25	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
28858478-9	2017	Overall, we found two BPA analogues BPAF and BPB could exert higher estrogenic effects than BPA via GPER pathway at nanomolar concentrations.	4,4'-hexafluorisopropylidene diphenol	36-40	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
28858478-9	2017	Overall, we found two BPA analogues BPAF and BPB could exert higher estrogenic effects than BPA via GPER pathway at nanomolar concentrations.	bisphenol B	45-48	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
28858478-9	2017	Overall, we found two BPA analogues BPAF and BPB could exert higher estrogenic effects than BPA via GPER pathway at nanomolar concentrations.	bisphenol A	36-39	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
28902352-0	2017	GPER promotes tamoxifen-resistance in ER+ breast cancer cells by reduced Bim proteins through MAPK/Erk-TRIM2 signaling axis.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
28902352-2	2017	Our previous studies find that GPER and its down-stream signaling play a pivotal role in the development of tamoxifen (TAM) resistance.	Tamoxifen	108-117	G protein-coupled estrogen receptor 1	Homo sapiens	31-35
28902352-2	2017	Our previous studies find that GPER and its down-stream signaling play a pivotal role in the development of tamoxifen (TAM) resistance.	Tamoxifen	119-122	G protein-coupled estrogen receptor 1	Homo sapiens	31-35
28902352-3	2017	cDNA array analysis indicated a set of genes associated with cell apoptosis are aberrant in GPER activated and TAM-resistant MCF-7R cells compared with TAM-sensitive MCF-7 cells.	Tamoxifen	152-155	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
29137421-3	2017	This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression.	Estradiol	169-185	G protein-coupled estrogen receptor 1	Homo sapiens	140-144
29137421-3	2017	This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression.	Estradiol	169-185	G protein-coupled estrogen receptor 1	Homo sapiens	146-151
29137421-3	2017	This raises questions about the role of signalling through other estrogen receptors such as ERalpha or G-protein coupled estrogen receptor (GPER, GPR30) by the estrogen 17beta-estradiol (E2) under hypoxic conditions after ERbeta is lost in CRC progression.	Estradiol	169-185	G protein-coupled estrogen receptor 1	Homo sapiens	103-138
28596490-6	2017	We discovered that interfering with N-linked glycosylation of GPER, either by mutation of the predicted glycosylation sites or pharmacologically with tunicamycin, drives GPER into the nucleus.	Nitrogen	36-37	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
28645860-4	2017	MAIN METHODS: Third-order mesenteric arteries were isolated, and concentration-response curves were plotted following the cumulative addition of the selective GPER agonist G-1 (1nM-10muM) following induction of contraction with phenylephrine (3muM).	coumarin-3-carboxylic acid	172-175	G protein-coupled estrogen receptor 1	Homo sapiens	159-163
28789417-10	2017	In addition, baicalein significantly inhibited G-1, a specific GPR30 agonist, induced invasion, and reduced G-1 promoted expression and activity of MMP-9, consistent with effects of G15.	baicalein	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
28596490-6	2017	We discovered that interfering with N-linked glycosylation of GPER, either by mutation of the predicted glycosylation sites or pharmacologically with tunicamycin, drives GPER into the nucleus.	Nitrogen	36-37	G protein-coupled estrogen receptor 1	Homo sapiens	170-174
28596490-6	2017	We discovered that interfering with N-linked glycosylation of GPER, either by mutation of the predicted glycosylation sites or pharmacologically with tunicamycin, drives GPER into the nucleus.	Tunicamycin	150-161	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
28466560-0	2017	Bisphenol A triggers proliferation and migration of laryngeal squamous cell carcinoma via GPER mediated upregulation of IL-6.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
28596490-6	2017	We discovered that interfering with N-linked glycosylation of GPER, either by mutation of the predicted glycosylation sites or pharmacologically with tunicamycin, drives GPER into the nucleus.	Tunicamycin	150-161	G protein-coupled estrogen receptor 1	Homo sapiens	170-174
28450397-2	2017	We showed recently that GPR30 interacts through the C-terminal type I PDZ motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the receptor in the plasma membrane and mediate an apparently constitutive decrease in cAMP production independently of Gi/o Here, we show that GPR30 also constitutively increases ERK1/2 activity.	Cyclic AMP	246-250	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
28412354-2	2017	In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis.	Estradiol	53-69	G protein-coupled estrogen receptor 1	Homo sapiens	104-133
28412354-2	2017	In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis.	Estradiol	53-69	G protein-coupled estrogen receptor 1	Homo sapiens	135-140
28412354-2	2017	In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis.	Estradiol	74-76	G protein-coupled estrogen receptor 1	Homo sapiens	104-133
28412354-2	2017	In the present study, we demonstrated that estrogen (17beta-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis.	Estradiol	74-76	G protein-coupled estrogen receptor 1	Homo sapiens	135-140
28412354-3	2017	Both E2 and the GPR30-specific agonist G1 induced a transient intracellular Ca2+ release in PECs via the phospholipase C (PLC)-inositol 1, 4, 5-triphosphate (IP3) pathway, and this was abolished by treatment with the GPR30 antagonist G15.	Inositol 1,4,5-Trisphosphate	127-156	G protein-coupled estrogen receptor 1	Homo sapiens	16-21
28412354-3	2017	Both E2 and the GPR30-specific agonist G1 induced a transient intracellular Ca2+ release in PECs via the phospholipase C (PLC)-inositol 1, 4, 5-triphosphate (IP3) pathway, and this was abolished by treatment with the GPR30 antagonist G15.	Inositol 1,4,5-Trisphosphate	158-161	G protein-coupled estrogen receptor 1	Homo sapiens	16-21
28412354-5	2017	Data generated from the analysis of animal models and human clinical samples indicate that treatment with the GPR30 agonist relieves testosterone propionate (TP)-induced prostatic epithelial hyperplasia, and that the abundance of GPR30 is negatively associated with prostate volume.	Testosterone Propionate	133-156	G protein-coupled estrogen receptor 1	Homo sapiens	110-115
28412354-5	2017	Data generated from the analysis of animal models and human clinical samples indicate that treatment with the GPR30 agonist relieves testosterone propionate (TP)-induced prostatic epithelial hyperplasia, and that the abundance of GPR30 is negatively associated with prostate volume.	Testosterone Propionate	158-160	G protein-coupled estrogen receptor 1	Homo sapiens	110-115
28466560-9	2017	The increased IL-6 can further activate its downstream signal molecule STAT3, which was evidenced by the results of increased phosphorylation and nuclear translocation of STAT3, while si-IL-6 and si-GPER can both reverse BPA-induced activation of STAT3.	bisphenol A	221-224	G protein-coupled estrogen receptor 1	Homo sapiens	199-203
28466560-10	2017	Collectively, our present study revealed that BPA can trigger the progression of LSCC via GPER-mediated upregulation of IL-6.	bisphenol A	46-49	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
28476123-6	2017	RESULTS: GPER was significantly (p &lt; 0.01) down regulated in CRC tissues compared with their matched adjacent normal tissues in our two cohorts and three independent investigations from Oncomine database.	oncomine	189-197	G protein-coupled estrogen receptor 1	Homo sapiens	9-13
28348059-6	2017	Experiments with the PFKFB3 inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one showed that PFKFB3 activity was required for estrogen-mediated HUVEC migration via GPER1.	3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one	38-84	G protein-coupled estrogen receptor 1	Homo sapiens	168-173
28286086-7	2017	We analyzed the expression levels of GPER1 mRNA variants in MCF-7 and MDA-MB-231 cells by RT-PCR, and the methylation status of two CpG islands in the GPER1 locus by modified COBRA assays and bisulfite sequencing.	hydrogen sulfite	192-201	G protein-coupled estrogen receptor 1	Homo sapiens	151-156
28286086-12	2017	5-Azacytidine, a DNA methyltransferase inhibitor, induced the expression levels of GPER1 mRNA variants in MDA-MB-231 cells.	Azacitidine	0-13	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
28440394-13	2017	The expression of GPR30 in endothelial cells was significantly increased following treatment with 17-beta-estradiol under H/R conditions.	Estradiol	98-115	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
27721408-6	2017	Moreover, the clinical data from 18F-fluorodeoxyglucose positron emission tomography/computed tomography further present a strong association between the GPER/cAMP/PKA/CREB pathway of stromal fibroblasts with tumor metabolic activity and clinical treatment, suggesting that targeting cytoplasmic GPER in CAFs may rescue the drug sensitivity in patients with breast cancer.	Fluorodeoxyglucose F18	33-55	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
27837347-5	2017	Both TAM and estradiol (E2) could promote the migration of triple negative (ER-alpha66-/PR-/HER2-) and ER-alpha36+/GPER1+ breast cancer cells MDA-MB-231.	Tamoxifen	5-8	G protein-coupled estrogen receptor 1	Homo sapiens	115-120
27837347-5	2017	Both TAM and estradiol (E2) could promote the migration of triple negative (ER-alpha66-/PR-/HER2-) and ER-alpha36+/GPER1+ breast cancer cells MDA-MB-231.	Estradiol	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	115-120
28096479-2	2017	We recently demonstrated that G protein-coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor-binding protein-1 (IGFBP-1) to inhibit IGF-1-dependent signaling.	Tamoxifen	85-94	G protein-coupled estrogen receptor 1	Homo sapiens	30-67
28096479-2	2017	We recently demonstrated that G protein-coupled estrogen receptor 1 (GPER1) mediates tamoxifen action in breast cancer cells by inducing insulin-like growth factor-binding protein-1 (IGFBP-1) to inhibit IGF-1-dependent signaling.	Tamoxifen	85-94	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
27721408-0	2017	Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance.	Cyclic AMP	73-77	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
27721408-4	2017	Here we first show that the breast tumor cell-activated PI3K/AKT (phosphoinositide 3-kinase/AKT) signaling pathway induces the cytoplasmic GPER translocation of CAFs in a CRM1-dependent pattern, and leads to the activation of a novel estrogen/GPER/cAMP/PKA/CREB signaling axis that triggers the aerobic glycolysis switch in CAFs.	Cyclic AMP	248-252	G protein-coupled estrogen receptor 1	Homo sapiens	139-143
27401115-3	2017	MATERIALS AND METHODS: The phosphorylation or expression levels of ERK1/2, Akt, c-Fos and eNOS were evaluated to assess GPR30 activation in response to known agonists (17beta-estradiol and G-1) in MCF-7 and T-47D breast cancer cell lines and in bovine aortic endothelial cells.	Estradiol	168-184	G protein-coupled estrogen receptor 1	Homo sapiens	120-125
27721408-6	2017	Moreover, the clinical data from 18F-fluorodeoxyglucose positron emission tomography/computed tomography further present a strong association between the GPER/cAMP/PKA/CREB pathway of stromal fibroblasts with tumor metabolic activity and clinical treatment, suggesting that targeting cytoplasmic GPER in CAFs may rescue the drug sensitivity in patients with breast cancer.	Fluorodeoxyglucose F18	33-55	G protein-coupled estrogen receptor 1	Homo sapiens	296-300
27721408-4	2017	Here we first show that the breast tumor cell-activated PI3K/AKT (phosphoinositide 3-kinase/AKT) signaling pathway induces the cytoplasmic GPER translocation of CAFs in a CRM1-dependent pattern, and leads to the activation of a novel estrogen/GPER/cAMP/PKA/CREB signaling axis that triggers the aerobic glycolysis switch in CAFs.	Cyclic AMP	248-252	G protein-coupled estrogen receptor 1	Homo sapiens	243-247
27721408-6	2017	Moreover, the clinical data from 18F-fluorodeoxyglucose positron emission tomography/computed tomography further present a strong association between the GPER/cAMP/PKA/CREB pathway of stromal fibroblasts with tumor metabolic activity and clinical treatment, suggesting that targeting cytoplasmic GPER in CAFs may rescue the drug sensitivity in patients with breast cancer.	Cyclic AMP	159-163	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
27721408-6	2017	Moreover, the clinical data from 18F-fluorodeoxyglucose positron emission tomography/computed tomography further present a strong association between the GPER/cAMP/PKA/CREB pathway of stromal fibroblasts with tumor metabolic activity and clinical treatment, suggesting that targeting cytoplasmic GPER in CAFs may rescue the drug sensitivity in patients with breast cancer.	Cyclic AMP	159-163	G protein-coupled estrogen receptor 1	Homo sapiens	296-300
27814026-0	2017	GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer.	Steroids	47-63	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
28098854-3	2017	In this study, we demonstrate that beta-estradiol (E2) treatment increased LSD1 expression via the GPR30/PI3K/AKT pathway in endometrial cancer cells.	Estradiol	35-49	G protein-coupled estrogen receptor 1	Homo sapiens	99-104
27880919-1	2017	Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERalpha) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation.	bisphenol A	57-68	G protein-coupled estrogen receptor 1	Homo sapiens	190-195
27880919-1	2017	Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERalpha) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation.	bisphenol A	70-73	G protein-coupled estrogen receptor 1	Homo sapiens	190-195
27341075-3	2017	In the present study, we demonstrate that zinc chloride (ZnCl2 ) involves GPER in the activation of insulin-like growth factor receptor I (IGF-IR)/epidermal growth factor receptor (EGFR)-mediated signaling, which in turn triggers downstream pathways like ERK and AKT in breast cancer cells, and main components of the tumor microenvironment namely cancer-associated fibroblasts (CAFs).	zinc chloride	42-55	G protein-coupled estrogen receptor 1	Homo sapiens	74-78
27341075-3	2017	In the present study, we demonstrate that zinc chloride (ZnCl2 ) involves GPER in the activation of insulin-like growth factor receptor I (IGF-IR)/epidermal growth factor receptor (EGFR)-mediated signaling, which in turn triggers downstream pathways like ERK and AKT in breast cancer cells, and main components of the tumor microenvironment namely cancer-associated fibroblasts (CAFs).	zinc chloride	57-62	G protein-coupled estrogen receptor 1	Homo sapiens	74-78
27341075-4	2017	Further corroborating these findings, ZnCl2 stimulates a functional crosstalk of GPER with IGF-IR and EGFR toward the transcription of diverse GPER target genes.	zinc chloride	38-43	G protein-coupled estrogen receptor 1	Homo sapiens	81-85
27341075-4	2017	Further corroborating these findings, ZnCl2 stimulates a functional crosstalk of GPER with IGF-IR and EGFR toward the transcription of diverse GPER target genes.	zinc chloride	38-43	G protein-coupled estrogen receptor 1	Homo sapiens	143-147
27341075-5	2017	Then, we show that GPER contributes to the stimulatory effects induced by ZnCl2 on cell-cycle progression, proliferation, and migration of breast cancer cells as well as migration of CAFs.	zinc chloride	74-79	G protein-coupled estrogen receptor 1	Homo sapiens	19-23
27959426-0	2017	17beta-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
27959426-0	2017	17beta-estradiol-induced growth of triple-negative breast cancer cells is prevented by the reduction of GPER expression after treatment with gefitinib.	Gefitinib	141-150	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
27959426-3	2017	To a certain extent the growth of TNBCs is stimulated by 17beta-estradiol via GPER.	Estradiol	57-73	G protein-coupled estrogen receptor 1	Homo sapiens	78-82
27959426-4	2017	We analyzed whether inhibition of EGFR by gefitinib reduces the expression of GPER and subsequent signal transduction in TNBC cells.	Gefitinib	42-51	G protein-coupled estrogen receptor 1	Homo sapiens	78-82
27959426-6	2017	Expression of GPR30 and activation of c-src, EGFR and cAMP-responsive element binding (CREB) protein by 17beta-estradiol was analyzed by western blotting.	Estradiol	104-120	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
27959426-8	2017	Gefitinib reduced GPER expression concentration- and time-dependently.	Gefitinib	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	18-22
27959426-9	2017	In HCC70 cells, GPER expression was reduced to 15+-11% (p&lt;0.05) after treatment with 200 nM gefitinib for four days, and in HCC1806 cells GPER expression was reduced to 39+-5% (p&lt;0.01) of the control.	Gefitinib	95-104	G protein-coupled estrogen receptor 1	Homo sapiens	16-20
27959426-9	2017	In HCC70 cells, GPER expression was reduced to 15+-11% (p&lt;0.05) after treatment with 200 nM gefitinib for four days, and in HCC1806 cells GPER expression was reduced to 39+-5% (p&lt;0.01) of the control.	Gefitinib	95-104	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
27959426-11	2017	This increase in cell growth was completely prevented in both TNBC cell lines after GPR30 expression was downregulated by treatment with 200 nM gefitinib.	Gefitinib	144-153	G protein-coupled estrogen receptor 1	Homo sapiens	84-89
28278256-1	2017	Previously, we reported that cAMP/PKA signaling is involved in GPER-mediated coronary relaxation by activating MLCP via inhibition of RhoA pathway.	Cyclic AMP	29-33	G protein-coupled estrogen receptor 1	Homo sapiens	63-67
28278256-2	2017	In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by cAMP downstream targets, exchange proteins directly activated by cAMP (Epac) as well as PKA.	Cyclic AMP	151-155	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
28278256-2	2017	In the current study, we tested the hypothesis that activation of GPER induces coronary artery relaxation via inhibition of RhoA/Rho kinase pathway by cAMP downstream targets, exchange proteins directly activated by cAMP (Epac) as well as PKA.	Cyclic AMP	216-220	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
28278256-3	2017	Our results show that Epac inhibitors, brefeldin A (BFA, 50 muM), or ESI-09 (20 muM), or CE3F4 (100 muM), all partially inhibited porcine coronary artery relaxation response to the selective GPER agonist, G-1 (0.3-3 muM); while concurrent administration of BFA and PKI (5 muM), a PKA inhibitor, almost completely blocked the relaxation effect of G-1.	3-(5-tert-butylisoxazol-3-yl)-2-((3-chlorophenyl)hydrazono)-3-oxopropionitrile	69-75	G protein-coupled estrogen receptor 1	Homo sapiens	191-195
28326039-11	2017	Furthermore, tamoxifen and fulvestrant, known GPER agonist, also increased CRC STS activity, with this effect inhibited by the GPER antagonist G15.	Tamoxifen	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
28326039-11	2017	Furthermore, tamoxifen and fulvestrant, known GPER agonist, also increased CRC STS activity, with this effect inhibited by the GPER antagonist G15.	Tamoxifen	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
28326039-11	2017	Furthermore, tamoxifen and fulvestrant, known GPER agonist, also increased CRC STS activity, with this effect inhibited by the GPER antagonist G15.	Fulvestrant	27-38	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
28326039-11	2017	Furthermore, tamoxifen and fulvestrant, known GPER agonist, also increased CRC STS activity, with this effect inhibited by the GPER antagonist G15.	Fulvestrant	27-38	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
27940299-0	2017	GPER/ERK&amp;AKT/NF-kappaB pathway is involved in cadmium-induced proliferation, invasion and migration of GPER-positive thyroid cancer cells.	Cadmium	50-57	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
27940299-0	2017	GPER/ERK&amp;AKT/NF-kappaB pathway is involved in cadmium-induced proliferation, invasion and migration of GPER-positive thyroid cancer cells.	Cadmium	50-57	G protein-coupled estrogen receptor 1	Homo sapiens	107-111
27940299-3	2017	In the present study, we demonstrate that similar to E2 and G1, a specific agonist for G protein-coupled estrogen receptor (GPER), Cd induces the proliferation, invasion and migration of human WRO and FRO thyroid cancer cells that have endogenous GPER.	Cadmium	131-133	G protein-coupled estrogen receptor 1	Homo sapiens	87-122
27940299-3	2017	In the present study, we demonstrate that similar to E2 and G1, a specific agonist for G protein-coupled estrogen receptor (GPER), Cd induces the proliferation, invasion and migration of human WRO and FRO thyroid cancer cells that have endogenous GPER.	Cadmium	131-133	G protein-coupled estrogen receptor 1	Homo sapiens	124-128
27940299-3	2017	In the present study, we demonstrate that similar to E2 and G1, a specific agonist for G protein-coupled estrogen receptor (GPER), Cd induces the proliferation, invasion and migration of human WRO and FRO thyroid cancer cells that have endogenous GPER.	Cadmium	131-133	G protein-coupled estrogen receptor 1	Homo sapiens	247-251
27940299-4	2017	Moreover, like E2 and G1, Cd leads to a rapid activation of ERK/AKT, and then nuclear translocation of NF-kappaB, increased expression of cyclin A and D1, and secretion of IL-8, all of which are significantly attenuated by GPER blockage or knock-down in both WRO and FRO cells.	Cadmium	26-28	G protein-coupled estrogen receptor 1	Homo sapiens	223-227
27940299-5	2017	Furthermore, the Cd-induced proliferation, invasion and migration are suppressed either by specific inhibitors for GPER, ERK, AKT and NF-kappaB, or by knock-down of GPER.	Cadmium	17-19	G protein-coupled estrogen receptor 1	Homo sapiens	115-119
27940299-5	2017	Furthermore, the Cd-induced proliferation, invasion and migration are suppressed either by specific inhibitors for GPER, ERK, AKT and NF-kappaB, or by knock-down of GPER.	Cadmium	17-19	G protein-coupled estrogen receptor 1	Homo sapiens	165-169
27940299-6	2017	These results suggest that GPER/ERK&amp;AKT/NF-kappaB signaling pathway is involved in the Cd-induced proliferation, invasion and migration of GPER-positive thyroid cancer cells.	Cadmium	91-93	G protein-coupled estrogen receptor 1	Homo sapiens	27-31
27940299-6	2017	These results suggest that GPER/ERK&amp;AKT/NF-kappaB signaling pathway is involved in the Cd-induced proliferation, invasion and migration of GPER-positive thyroid cancer cells.	Cadmium	91-93	G protein-coupled estrogen receptor 1	Homo sapiens	143-147
27796870-0	2017	GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP+-Induced SH-SY5Y Cell Death.	puerarin	36-44	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
27796870-4	2017	In this study, we investigated whether puerarin prevented against 1-methyl-4-phenylpyridinium (MPP+)-induced cell death via GPR30.	puerarin	39-47	G protein-coupled estrogen receptor 1	Homo sapiens	124-129
27796870-5	2017	Our results showed that the GPR30 agonist, G1, exhibited puerarin-mediated neuroprotection against MPP+-induced cell death of SH-SY5Y cells.	puerarin	57-65	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
27796870-5	2017	Our results showed that the GPR30 agonist, G1, exhibited puerarin-mediated neuroprotection against MPP+-induced cell death of SH-SY5Y cells.	mangion-purified polysaccharide (Candida albicans)	99-103	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
27796870-7	2017	Moreover, a time- and concentration-dependent effect of puerarin on GPR30 expression was verified at the protein level but not at the mRNA level.	puerarin	56-64	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
27796870-8	2017	Further, we showed that an mTor-dependent new GPR30 synthesis contributed to the protection conferred by puerarin.	puerarin	105-113	G protein-coupled estrogen receptor 1	Homo sapiens	46-51
27796870-10	2017	Taken together, our data strongly suggest that puerarin prevents MPP+-induced cell death via facilitating GPR30 expression and GDNF release.	puerarin	47-55	G protein-coupled estrogen receptor 1	Homo sapiens	106-111
27796870-10	2017	Taken together, our data strongly suggest that puerarin prevents MPP+-induced cell death via facilitating GPR30 expression and GDNF release.	mangion-purified polysaccharide (Candida albicans)	65-69	G protein-coupled estrogen receptor 1	Homo sapiens	106-111
27760898-7	2017	However, blockade of Gper1 by its antagonist G-15 did not affect the inhibitory action of E2 on IGF-1-induced proliferation.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
31988900-9	2017	Results: Human neutrophils express a functional GPER1 which regulates their functions through cAMP/protein kinase A/cAMP response element-binding protein, p38 mitogen-activated protein kinase, and extracellular regulated MAPK signaling pathways.	Cyclic AMP	94-98	G protein-coupled estrogen receptor 1	Homo sapiens	48-53
31988900-9	2017	Results: Human neutrophils express a functional GPER1 which regulates their functions through cAMP/protein kinase A/cAMP response element-binding protein, p38 mitogen-activated protein kinase, and extracellular regulated MAPK signaling pathways.	Cyclic AMP	116-120	G protein-coupled estrogen receptor 1	Homo sapiens	48-53
27814026-0	2017	GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer.	Steroids	47-63	G protein-coupled estrogen receptor 1	Homo sapiens	6-11
27814026-1	2017	Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways.	Steroids	30-38	G protein-coupled estrogen receptor 1	Homo sapiens	237-264
27814026-1	2017	Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways.	Steroids	30-38	G protein-coupled estrogen receptor 1	Homo sapiens	266-270
27814026-1	2017	Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways.	Steroids	30-38	G protein-coupled estrogen receptor 1	Homo sapiens	392-396
27814026-5	2017	This review provides a summary of relevant findings of the impact of GPER regulation by either estradiol or aldosterone in in vitro model systems and extends those findings to in vivo studies of direct clinical relevance for development of GPER-directed agents for treatment of cancer and cardiovascular diseases associated with cellular proliferation.	Estradiol	95-104	G protein-coupled estrogen receptor 1	Homo sapiens	69-73
27814026-5	2017	This review provides a summary of relevant findings of the impact of GPER regulation by either estradiol or aldosterone in in vitro model systems and extends those findings to in vivo studies of direct clinical relevance for development of GPER-directed agents for treatment of cancer and cardiovascular diseases associated with cellular proliferation.	Aldosterone	108-119	G protein-coupled estrogen receptor 1	Homo sapiens	69-73
29059676-12	2017	AR activation triggered by DHT suppressed GPER expression, to promote cell growth of TNBC.	Dihydrotestosterone	27-30	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
29224098-7	2017	In humans, 17beta-estradiol (E2) is the predominant circulating estrogen and signals through estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), and G-protein-coupled estrogen receptor (GPER).	Estradiol	11-27	G protein-coupled estrogen receptor 1	Homo sapiens	165-200
29224098-7	2017	In humans, 17beta-estradiol (E2) is the predominant circulating estrogen and signals through estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), and G-protein-coupled estrogen receptor (GPER).	Estradiol	11-27	G protein-coupled estrogen receptor 1	Homo sapiens	202-206
28662498-8	2017	ERs and GPER blockers were able to prevent the effects of 17beta-estradiol and genistein.	Estradiol	58-74	G protein-coupled estrogen receptor 1	Homo sapiens	8-12
28662498-8	2017	ERs and GPER blockers were able to prevent the effects of 17beta-estradiol and genistein.	Genistein	79-88	G protein-coupled estrogen receptor 1	Homo sapiens	8-12
29059676-13	2017	G-1, a GPER agonist, inhibited DHT-stimulated proliferation.	Dihydrotestosterone	31-34	G protein-coupled estrogen receptor 1	Homo sapiens	7-11
27378491-5	2017	Estradiol-induced melanin synthesis and the activation of related signaling pathways were suppressed by inhibiting GPER via antagonist treatment.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	115-119
28662498-9	2017	CONCLUSION: In Huh7.5 and LX-2, 17beta-estradiol and genistein counteract the effects of peroxidation through the involvement of ERs and GPER and by an intracellular signalling related to Akt and p38MAPK.	Estradiol	32-48	G protein-coupled estrogen receptor 1	Homo sapiens	137-141
28662498-9	2017	CONCLUSION: In Huh7.5 and LX-2, 17beta-estradiol and genistein counteract the effects of peroxidation through the involvement of ERs and GPER and by an intracellular signalling related to Akt and p38MAPK.	Genistein	53-62	G protein-coupled estrogen receptor 1	Homo sapiens	137-141
27942913-5	2017	Recently, G protein-coupled estrogen receptor-1 (GPER-1) was elegantly shown to mediate some aldosterone-induced rapid effects in several tissues, a fact that strongly places GPER-1 as the unknown receptor.	Aldosterone	93-104	G protein-coupled estrogen receptor 1	Homo sapiens	10-47
27942913-5	2017	Recently, G protein-coupled estrogen receptor-1 (GPER-1) was elegantly shown to mediate some aldosterone-induced rapid effects in several tissues, a fact that strongly places GPER-1 as the unknown receptor.	Aldosterone	93-104	G protein-coupled estrogen receptor 1	Homo sapiens	49-55
27942913-5	2017	Recently, G protein-coupled estrogen receptor-1 (GPER-1) was elegantly shown to mediate some aldosterone-induced rapid effects in several tissues, a fact that strongly places GPER-1 as the unknown receptor.	Aldosterone	93-104	G protein-coupled estrogen receptor 1	Homo sapiens	175-181
27378491-5	2017	Estradiol-induced melanin synthesis and the activation of related signaling pathways were suppressed by inhibiting GPER via antagonist treatment.	Melanins	18-25	G protein-coupled estrogen receptor 1	Homo sapiens	115-119
27369115-6	2017	Combined 5nM treatments with specific estrogen and progesterone receptor agonists showed an involvement of membrane progesterone receptor alpha (mPRalpha, also known as PAQR7), G protein-coupled estrogen receptor 1 (GPER), and estrogen receptor alpha (ERalpha), but not ERbeta, in P4+E2 stimulation of NO production.	3-[[5-Bromanyl-1-(3-Methylsulfonylpropyl)benzimidazol-2-Yl]methyl]-1-Cyclopropyl-Imidazo[4,5-C]pyridin-2-One	9-12	G protein-coupled estrogen receptor 1	Homo sapiens	177-214
27369115-6	2017	Combined 5nM treatments with specific estrogen and progesterone receptor agonists showed an involvement of membrane progesterone receptor alpha (mPRalpha, also known as PAQR7), G protein-coupled estrogen receptor 1 (GPER), and estrogen receptor alpha (ERalpha), but not ERbeta, in P4+E2 stimulation of NO production.	3-[[5-Bromanyl-1-(3-Methylsulfonylpropyl)benzimidazol-2-Yl]methyl]-1-Cyclopropyl-Imidazo[4,5-C]pyridin-2-One	9-12	G protein-coupled estrogen receptor 1	Homo sapiens	216-220
27378491-8	2017	GPER activated melanin production via the cAMP-protein kinase (PK) A pathway, suggesting that GPER plays an important role in estrogen-induced melanin synthesis.	Melanins	15-22	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
27378491-8	2017	GPER activated melanin production via the cAMP-protein kinase (PK) A pathway, suggesting that GPER plays an important role in estrogen-induced melanin synthesis.	Melanins	15-22	G protein-coupled estrogen receptor 1	Homo sapiens	94-98
27378491-8	2017	GPER activated melanin production via the cAMP-protein kinase (PK) A pathway, suggesting that GPER plays an important role in estrogen-induced melanin synthesis.	Melanins	143-150	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
27378491-8	2017	GPER activated melanin production via the cAMP-protein kinase (PK) A pathway, suggesting that GPER plays an important role in estrogen-induced melanin synthesis.	Melanins	143-150	G protein-coupled estrogen receptor 1	Homo sapiens	94-98
27378491-9	2017	The effect of GPER activation on cAMP-MITF-TYR signaling was also demonstrated in B16 cells.	Cyclic AMP	33-37	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
27378491-11	2017	CONCLUSION: GPER enhances melanin synthesis via cAMP-PKA-MITF-TYR signaling and modulates the effects of estrogen in melanogenesis.	Melanins	26-33	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
27378491-11	2017	CONCLUSION: GPER enhances melanin synthesis via cAMP-PKA-MITF-TYR signaling and modulates the effects of estrogen in melanogenesis.	Cyclic AMP	48-52	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
27822058-6	2016	Interestingly, higher expression of GPER1 was associated with poorer DFS in HER2-positive subtype of breast cancer (P=0.047) but with better DMFS (P=0.040) and DFS (P=0.035) in HER2-negative subtype of breast cancer.	dmfs	141-145	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
27222231-0	2017	PI3K/Akt Activated by GPR30 and Src Regulates 17beta-Estradiol-Induced Cultured Immature Boar Sertoli Cells Proliferation.	Estradiol	46-62	G protein-coupled estrogen receptor 1	Homo sapiens	22-27
27222231-7	2017	Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2).	G-15	5-9	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
27222231-7	2017	Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2).	Estradiol	101-117	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
27519631-0	2016	Tamoxifen has a proliferative effect in endometrial carcinoma mediated via the GPER/EGFR/ERK/cyclin D1 pathway: A retrospective study and an in vitro study.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	79-83
27519631-5	2016	In vitro 4-hydroxytamoxifen (OHT) induced cell proliferation and cell cycle promotion in type I and type II endometrial cancer cell lines, and this proliferation was blocked by GPER silencing.	hydroxytamoxifen	9-27	G protein-coupled estrogen receptor 1	Homo sapiens	177-181
27519631-5	2016	In vitro 4-hydroxytamoxifen (OHT) induced cell proliferation and cell cycle promotion in type I and type II endometrial cancer cell lines, and this proliferation was blocked by GPER silencing.	Tamoxifen	29-32	G protein-coupled estrogen receptor 1	Homo sapiens	177-181
27849354-0	2016	The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1.	flaxseed-derived secoisolariciresinol diglycoside	25-74	G protein-coupled estrogen receptor 1	Homo sapiens	152-189
27849354-0	2016	The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1.	2,3-bis(3'-hydroxybenzyl)butyrolactone	94-107	G protein-coupled estrogen receptor 1	Homo sapiens	152-189
27849354-3	2016	The present study showed that enterolactone (ENL), the mammalian metabolite of SDG, shared the similar binding site of G1 on a new type of membranous estrogen receptor, G-protein-coupled estrogen eceptor 1 (GPER), by docking simulations method.	2,3-bis(3'-hydroxybenzyl)butyrolactone	30-43	G protein-coupled estrogen receptor 1	Homo sapiens	169-205
27849354-3	2016	The present study showed that enterolactone (ENL), the mammalian metabolite of SDG, shared the similar binding site of G1 on a new type of membranous estrogen receptor, G-protein-coupled estrogen eceptor 1 (GPER), by docking simulations method.	2,3-bis(3'-hydroxybenzyl)butyrolactone	30-43	G protein-coupled estrogen receptor 1	Homo sapiens	207-211
27849354-4	2016	ENL and G1 (the specific agonist of GPER) inhibited the proliferation of human prostate stromal cell line WPMY-1 as shown by MTT assay and arrested cell cycle at the G0/G1 phase, which was displayed by propidium iodide staining following flow cytometer examination.	monooxyethylene trimethylolpropane tristearate	125-128	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
27849354-4	2016	ENL and G1 (the specific agonist of GPER) inhibited the proliferation of human prostate stromal cell line WPMY-1 as shown by MTT assay and arrested cell cycle at the G0/G1 phase, which was displayed by propidium iodide staining following flow cytometer examination.	Propidium	202-218	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
27849354-8	2016	Mechanistic studies showed that SDG and ENL increased the expression of GPER both in vitro and in vivo.	secoisolariciresinol diglucoside	32-35	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
27222231-12	2017	Both GPR30 and Src are involved in 17beta-estradiol-induced phosphorylation of PI3K/Akt.	Estradiol	35-51	G protein-coupled estrogen receptor 1	Homo sapiens	5-10
27448983-1	2016	G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol.	Estradiol	95-104	G protein-coupled estrogen receptor 1	Homo sapiens	0-35
27745655-7	2016	BPA had no effects on either cellular distribution or protein expression of ERalpha, however, at 100mumol/L (or 23mumol/L intracellular BPA) increased ERbeta protein levels in the cytoplasmic fractions and GPR30 protein levels in the nuclear fractions.	bisphenol A	136-139	G protein-coupled estrogen receptor 1	Homo sapiens	206-211
27448983-1	2016	G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol.	Estradiol	95-104	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
27448983-9	2016	However, gene set enrichment analysis (GSEA) showed that GPER signaling is ultra-activated in ER-positive IBC when compared with normal and its activation is positively associated with NHERF1 mRNA levels.	gsea	39-43	G protein-coupled estrogen receptor 1	Homo sapiens	57-61
27271044-4	2016	Stimulation of HBE or 16HBE14o- cells with E2 or G1, a specific agonist of GPER, attenuated the nucleotide-evoked increases in [Ca(2+)]i, whereas this effect was reversed by G15, a GPER-specific antagonist.	16hbe14o	22-30	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
27480627-6	2016	Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER.	bisphenol A	127-130	G protein-coupled estrogen receptor 1	Homo sapiens	43-78
27480627-6	2016	Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER.	bisphenol A	127-130	G protein-coupled estrogen receptor 1	Homo sapiens	80-84
27480627-6	2016	Both estrogen receptor alpha (ERalpha) and G protein-coupled estrogen receptor (GPER) were expressed in HA cells; furthermore, BPA treatment can increase the expression of both ERalpha and GPER.	bisphenol A	127-130	G protein-coupled estrogen receptor 1	Homo sapiens	189-193
27271044-8	2016	These results demonstrated that the inhibitory effects of G1 or E2 on P2Y receptor-mediated Ca(2+) mobilization and cytokine secretion were due to GPER-mediated activation of a cAMP-dependent PKA pathway.	Cyclic AMP	177-181	G protein-coupled estrogen receptor 1	Homo sapiens	147-151
27113328-0	2016	GPER1 mediates estrogen-induced neuroprotection against oxygen-glucose deprivation in the primary hippocampal neurons.	oxygen-glucose	56-70	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
27113328-3	2016	Here our studies on primary hippocampal neurons have focused on GPER1 in an in vitro model of ischemia using oxygen-glucose deprivation (OGD).	oxygen-glucose	109-123	G protein-coupled estrogen receptor 1	Homo sapiens	64-69
27107933-6	2016	Furthermore, used in various treatment regimens anti-estrogens such as tamoxifen, raloxifen and fulvestrant (ICI 182.780), antagonists/modulators of canonical estrogen receptors, were found to be GPER agonists.	Tamoxifen	71-80	G protein-coupled estrogen receptor 1	Homo sapiens	196-200
27107933-6	2016	Furthermore, used in various treatment regimens anti-estrogens such as tamoxifen, raloxifen and fulvestrant (ICI 182.780), antagonists/modulators of canonical estrogen receptors, were found to be GPER agonists.	Fulvestrant	96-107	G protein-coupled estrogen receptor 1	Homo sapiens	196-200
27107933-6	2016	Furthermore, used in various treatment regimens anti-estrogens such as tamoxifen, raloxifen and fulvestrant (ICI 182.780), antagonists/modulators of canonical estrogen receptors, were found to be GPER agonists.	Raloxifen	82-91	G protein-coupled estrogen receptor 1	Homo sapiens	196-200
26921679-4	2016	Many of currently used drugs such as tamoxifen, raloxifene, or faslodex /fulvestrant were discovered targeting GPER many years after they had been introduced to the clinics for entirely different purposes.	Tamoxifen	37-46	G protein-coupled estrogen receptor 1	Homo sapiens	111-115
27189345-4	2016	Ligand-induced mER and GPER signalling events are shared with BCR, CD19 mediated intracellular signalling through phospholipase C, PIP2/IP3/PI3 mediated activation of Akt, MAP kinase, and mTOR.	Phosphatidylinositol 4,5-Diphosphate	131-135	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
27197110-4	2016	Three ER, ER-alpha, ER-beta and the G protein-coupled ER (GPER; also called GPR30) in tissues are involved in glucose and lipid homeostasis.	Glucose	110-117	G protein-coupled estrogen receptor 1	Homo sapiens	36-56
27197110-4	2016	Three ER, ER-alpha, ER-beta and the G protein-coupled ER (GPER; also called GPR30) in tissues are involved in glucose and lipid homeostasis.	Glucose	110-117	G protein-coupled estrogen receptor 1	Homo sapiens	58-62
27197110-4	2016	Three ER, ER-alpha, ER-beta and the G protein-coupled ER (GPER; also called GPR30) in tissues are involved in glucose and lipid homeostasis.	Glucose	110-117	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
26921679-4	2016	Many of currently used drugs such as tamoxifen, raloxifene, or faslodex /fulvestrant were discovered targeting GPER many years after they had been introduced to the clinics for entirely different purposes.	Raloxifene Hydrochloride	48-58	G protein-coupled estrogen receptor 1	Homo sapiens	111-115
26921679-4	2016	Many of currently used drugs such as tamoxifen, raloxifene, or faslodex /fulvestrant were discovered targeting GPER many years after they had been introduced to the clinics for entirely different purposes.	Fulvestrant	63-71	G protein-coupled estrogen receptor 1	Homo sapiens	111-115
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	G protein-coupled estrogen receptor 1	Homo sapiens	139-159
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	G protein-coupled estrogen receptor 1	Homo sapiens	161-165
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	Cadmium Chloride	69-74	G protein-coupled estrogen receptor 1	Homo sapiens	139-159
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	Cadmium Chloride	69-74	G protein-coupled estrogen receptor 1	Homo sapiens	161-165
28757722-12	2016	This suggests that 17beta-estradiol relaxes the human gallbladder via GPER.	Estradiol	19-35	G protein-coupled estrogen receptor 1	Homo sapiens	70-74
27071941-8	2016	This study supports the involvement of membrane ER and GPER signaling in mediating cellular responses to environmentally relevant nM concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.	Cadmium Chloride	151-156	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
27071941-8	2016	This study supports the involvement of membrane ER and GPER signaling in mediating cellular responses to environmentally relevant nM concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.	sodium arsenite	161-167	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
27111051-1	2016	UNLABELLED: Estradiol mediates its actions by binding to classical nuclear receptors, estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta), and the non-classical G protein-coupled estrogen receptor 1(GPER).	Estradiol	12-21	G protein-coupled estrogen receptor 1	Homo sapiens	181-218
27111051-1	2016	UNLABELLED: Estradiol mediates its actions by binding to classical nuclear receptors, estrogen receptor alpha (ER-alpha) and estrogen receptor beta (ER-beta), and the non-classical G protein-coupled estrogen receptor 1(GPER).	Estradiol	12-21	G protein-coupled estrogen receptor 1	Homo sapiens	219-223
27080432-7	2016	Binding at membrane-associated ERalpha and GPER1 could account for rapid estrogen-induced decreases in GABA transmission in the striatum, which, in turn, could affect dopamine transmission in this region.	gamma-Aminobutyric Acid	103-107	G protein-coupled estrogen receptor 1	Homo sapiens	43-48
27080432-7	2016	Binding at membrane-associated ERalpha and GPER1 could account for rapid estrogen-induced decreases in GABA transmission in the striatum, which, in turn, could affect dopamine transmission in this region.	Dopamine	167-175	G protein-coupled estrogen receptor 1	Homo sapiens	43-48
26981789-0	2016	The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells.	Methotrexate	73-85	G protein-coupled estrogen receptor 1	Homo sapiens	23-60
26981789-0	2016	The protective role of G protein-coupled estrogen receptor 1 (GPER-1) on methotrexate-induced nephrotoxicity in human renal epithelium cells.	Methotrexate	73-85	G protein-coupled estrogen receptor 1	Homo sapiens	62-68
27213340-4	2016	GPER is a recently appreciated GPCR that mediates the rapid effects of estrogen and aldosterone.	Aldosterone	84-95	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
27213340-8	2016	GPER appears to be an important determinant of the two major risk factors for coronary artery disease-blood pressure and LDL cholesterol.	Cholesterol	125-136	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
27115344-4	2016	Utilizing both genetic and pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7).	Steroids	75-82	G protein-coupled estrogen receptor 1	Homo sapiens	180-215
27115344-4	2016	Utilizing both genetic and pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7).	Steroids	75-82	G protein-coupled estrogen receptor 1	Homo sapiens	217-221
28757722-13	2016	CONCLUSION: These results demonstrate for the first time that 17beta-estradiol and GPER agonist G-1 cause relaxation of the human gallbladder, probably through GPER.	Estradiol	62-78	G protein-coupled estrogen receptor 1	Homo sapiens	160-164
26865461-7	2016	Here, we describe the role exerted by GPCR-mediated signaling in low oxygen conditions, discussing, in particular, the involvement of GPER by a hypoxic microenvironment.	Oxygen	69-75	G protein-coupled estrogen receptor 1	Homo sapiens	134-138
26914403-0	2016	Bisphenol A Induces Migration through a GPER-, FAK-, Src-, and ERK2-Dependent Pathway in MDA-MB-231 Breast Cancer Cells.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
26432358-6	2015	In conclusion, Estrogen suppresses breast cancer growth by inhibiting G1/S phase transition through GPER/ROS/p38 MAPK/p21 mediated signaling during hypoxic condition.	ros	105-108	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
26690777-0	2016	GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells.	Tamoxifen	72-81	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
25784559-0	2016	2,2",4,4"-Tetrabromodiphenyl ether promotes human neuroblastoma SH-SY5Y cells migration via the GPER/PI3K/Akt signal pathway.	2,2',4,4'-tetrabromodiphenyl ether	0-34	G protein-coupled estrogen receptor 1	Homo sapiens	96-100
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	phosphatidylinositol-4,	66-89	G protein-coupled estrogen receptor 1	Homo sapiens	21-58
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	phosphatidylinositol-4,	66-89	G protein-coupled estrogen receptor 1	Homo sapiens	60-64
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	phosphatidylinositol-4,	66-89	G protein-coupled estrogen receptor 1	Homo sapiens	244-248
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	21-58
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	60-64
25784559-7	2016	Further, the signals G protein-coupled estrogen receptor 1 (GPER)/phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (Akt) mediated the BDE-47-induced upregulation of MMP-9 and in vitro migration of SH-SY5Y cells since G15 (GPER inhibitor) and LY 294002 (PI3K/Akt inhibitor) significantly abolished the effects of BDE-47.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	264-273	G protein-coupled estrogen receptor 1	Homo sapiens	244-248
26646587-0	2016	GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells.	Aldosterone	47-58	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
26646587-4	2016	GPER has been also shown to contribute to certain responses to aldosterone, however the role played by GPER and the molecular mechanisms implicated remain to be fully understood.	Aldosterone	63-74	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
26646587-7	2016	Our results demonstrate that aldosterone triggers the EGFR/ERK transduction pathway in a MR- and GPER-dependent manner.	Aldosterone	29-40	G protein-coupled estrogen receptor 1	Homo sapiens	97-101
26646587-8	2016	Aldosterone does not bind to GPER, it however induces the direct interaction between MR and GPER as well as between GPER and EGFR.	Aldosterone	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
26646587-8	2016	Aldosterone does not bind to GPER, it however induces the direct interaction between MR and GPER as well as between GPER and EGFR.	Aldosterone	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
26646587-9	2016	Next, we ascertain that the up-regulation of the Na+/H+ exchanger-1 (NHE-1) induced by aldosterone involves MR and GPER.	Aldosterone	87-98	G protein-coupled estrogen receptor 1	Homo sapiens	115-119
26646587-10	2016	Biologically, both MR and GPER contribute to the proliferation and migration of breast and endothelial cancer cells mediated by NHE-1 upon aldosterone exposure.	Aldosterone	139-150	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
26646587-11	2016	Our data further extend the current knowledge on the molecular mechanisms through which GPER may contribute to the stimulatory action elicited by aldosterone in breast cancer.	Aldosterone	146-157	G protein-coupled estrogen receptor 1	Homo sapiens	88-92
26955487-0	2016	Differences in GPR30 Regulation by Chlorotriazine Herbicides in Human Breast Cells.	cyanuric chloride	35-49	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
26955487-2	2016	GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized chlorotriazines in agricultural practices in the United States.	Triazines	106-114	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
26955487-2	2016	GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized chlorotriazines in agricultural practices in the United States.	Atrazine	134-142	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
26955487-2	2016	GPR30, a G protein coupled receptor, was identified as a potential orphan receptor that may interact with triazine herbicides such as atrazine, one of the most commonly utilized chlorotriazines in agricultural practices in the United States.	cyanuric chloride	178-193	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
26955487-3	2016	Our goal was to identify whether chlorotriazines affected the expression of GPR30.	cyanuric chloride	33-48	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
26955487-6	2016	Our results indicate that GPR30 expression increased in breast cancer cells at levels lower than the US EPA drinking water contamination limit.	Water	117-122	G protein-coupled estrogen receptor 1	Homo sapiens	26-31
26955487-8	2016	In contrast, treatment with chlorotriazines reduced the expression of GPR30 in noncancerous MCF-10A cells.	cyanuric chloride	28-43	G protein-coupled estrogen receptor 1	Homo sapiens	70-75
26585123-2	2016	Recent studies have identified the G-protein-coupled receptor 30 (GPR30, GPER) as a high-affinity membrane receptor for 2-methoxyestradiol.	2-Methoxyestradiol	120-138	G protein-coupled estrogen receptor 1	Homo sapiens	35-64
26585123-2	2016	Recent studies have identified the G-protein-coupled receptor 30 (GPR30, GPER) as a high-affinity membrane receptor for 2-methoxyestradiol.	2-Methoxyestradiol	120-138	G protein-coupled estrogen receptor 1	Homo sapiens	66-71
26585123-2	2016	Recent studies have identified the G-protein-coupled receptor 30 (GPR30, GPER) as a high-affinity membrane receptor for 2-methoxyestradiol.	2-Methoxyestradiol	120-138	G protein-coupled estrogen receptor 1	Homo sapiens	73-77
26253279-0	2015	Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells.	methyl-, propyl- and butylparaben	10-43	G protein-coupled estrogen receptor 1	Homo sapiens	47-52
26415222-0	2015	Copper activates HIF-1alpha/GPER/VEGF signalling in cancer cells.	Copper	0-6	G protein-coupled estrogen receptor 1	Homo sapiens	28-32
26415222-3	2015	Here, we show that copper sulfate (CuSO4) induces the expression of HIF-1alpha as well as GPER and VEGF in breast and hepatic cancer cells through the activation of the EGFR/ERK/c-fos transduction pathway.	Copper Sulfate	19-33	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
26415222-3	2015	Here, we show that copper sulfate (CuSO4) induces the expression of HIF-1alpha as well as GPER and VEGF in breast and hepatic cancer cells through the activation of the EGFR/ERK/c-fos transduction pathway.	Copper Sulfate	35-40	G protein-coupled estrogen receptor 1	Homo sapiens	90-94
26415222-5	2015	We also ascertained that HIF-1alpha and GPER are required for the transcriptional activation of VEGF induced by CuSO4.	Copper Sulfate	112-117	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
26415222-6	2015	In addition, in human endothelial cells, the conditioned medium from breast cancer cells treated with CuSO4 promoted cell migration and tube formation through HIF-1alpha and GPER.	Copper Sulfate	102-107	G protein-coupled estrogen receptor 1	Homo sapiens	174-178
26253279-1	2015	In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells.	Cyclic AMP	34-38	G protein-coupled estrogen receptor 1	Homo sapiens	154-159
26253279-1	2015	In the present study, we examined cAMP levels and activation of the MAPK/ERK1/2 and PI3K/Akt signaling pathways in response to the actions of parabens on GPR30 in MCF-7 and MCF-10A cells.	Parabens	142-150	G protein-coupled estrogen receptor 1	Homo sapiens	154-159
26253279-3	2015	17beta-estradiol and all tested parabens increased GPR30 gene and protein expression in MCF-7 and MCF-10A cells.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
26253279-3	2015	17beta-estradiol and all tested parabens increased GPR30 gene and protein expression in MCF-7 and MCF-10A cells.	Parabens	32-40	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
26253279-7	2015	Collectively, the data presented here point to a nongenomic mechanism of action of parabens in activation GPR30 in both cancer and non-cancer breast cell lines through betagamma dimer-mediated activation of the ERK1/2 pathway, but not the cAMP/PKA pathway.	Parabens	83-91	G protein-coupled estrogen receptor 1	Homo sapiens	106-111
26400551-4	2015	Its binding to GPER was achieved by competition assays with [3H]E2 and [5,6-3H] nicotinic acid in ER-negative and GPER-positive SkBr3 breast cancer cells.	Tritium	61-63	G protein-coupled estrogen receptor 1	Homo sapiens	15-19
26400551-4	2015	Its binding to GPER was achieved by competition assays with [3H]E2 and [5,6-3H] nicotinic acid in ER-negative and GPER-positive SkBr3 breast cancer cells.	[5,6-3h] nicotinic acid	71-94	G protein-coupled estrogen receptor 1	Homo sapiens	15-19
26482875-1	2015	Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus.	Aldosterone	8-19	G protein-coupled estrogen receptor 1	Homo sapiens	34-69
26482875-1	2015	Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus.	Aldosterone	8-19	G protein-coupled estrogen receptor 1	Homo sapiens	71-75
26482875-3	2015	Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.	Aldosterone	181-192	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
26482875-3	2015	Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.	Aldosterone	181-192	G protein-coupled estrogen receptor 1	Homo sapiens	136-140
26482875-3	2015	Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.	Aldosterone	181-192	G protein-coupled estrogen receptor 1	Homo sapiens	136-140
26470790-3	2015	We previously reported that estrogen activates the phosphoinositide 3-kinase (PI3Kinase) pathway via GPER, resulting in phosphatidylinositol (3,4,5)-trisphosphate (PIP3) production within the nucleus of breast cancer cells; however, the mechanisms and consequences of this activity remained unclear.	phosphatidylinositol 3,4,5-triphosphate	120-162	G protein-coupled estrogen receptor 1	Homo sapiens	101-105
26470790-3	2015	We previously reported that estrogen activates the phosphoinositide 3-kinase (PI3Kinase) pathway via GPER, resulting in phosphatidylinositol (3,4,5)-trisphosphate (PIP3) production within the nucleus of breast cancer cells; however, the mechanisms and consequences of this activity remained unclear.	PIP3	164-168	G protein-coupled estrogen receptor 1	Homo sapiens	101-105
26470790-11	2015	The SERMs tamoxifen and raloxifene, as well as the SERD ICI182,780, were active in mediating FOXO3a inactivation in a GPER-dependent manner.	Tamoxifen	10-19	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
26470790-11	2015	The SERMs tamoxifen and raloxifene, as well as the SERD ICI182,780, were active in mediating FOXO3a inactivation in a GPER-dependent manner.	Raloxifene Hydrochloride	24-34	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
26200092-5	2015	Raloxifene induced a time-dependent increase in the level of phosphorylated ERK1 and ERK2, by a mechanism blocked by the GPER antagonist.	Raloxifene Hydrochloride	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	121-125
26170064-6	2015	Using primary mesencephalic cultures, we found that GPER activation protects dopaminergic neurons from MPP(+) toxicity in an extent similar to the promoted by a 17beta-estradiol.	mangion-purified polysaccharide (Candida albicans)	103-109	G protein-coupled estrogen receptor 1	Homo sapiens	52-56
26200092-7	2015	These results reveal a mechanism mediating the regulation of AVP expression by raloxifene, involving the activation of GPER, which in turn activates protein kinase C, MAPK/ERK kinase, and ERK.	Raloxifene Hydrochloride	79-89	G protein-coupled estrogen receptor 1	Homo sapiens	119-123
26183213-0	2015	A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and models.	calixpyrrole	2-14	G protein-coupled estrogen receptor 1	Homo sapiens	51-55
26183213-5	2015	Here, we provide evidence on the molecular mechanisms through which a calixpyrrole derivative acts as a GPER antagonist in different model systems, such as breast tumor cells and cancer-associated fibroblasts (CAFs) obtained from breast cancer patients.	calixpyrrole	70-82	G protein-coupled estrogen receptor 1	Homo sapiens	104-108
26183213-7	2015	Moreover, calixpyrrole derivatives could be considered in future anticancer strategies targeting GPER in cancer cells.	calixpyrrole	10-22	G protein-coupled estrogen receptor 1	Homo sapiens	97-101
26303299-13	2015	Selective activation of GPER may therefore be considered as a novel strategy to treat increased prostanoid-dependent vasomotor tone or vascular disease in postmenopausal women.	Prostaglandins	96-106	G protein-coupled estrogen receptor 1	Homo sapiens	24-28
25847233-4	2015	In primary endothelial cells, GPER/GPR30 agonist G-1 decreases PMCA-mediated Ca(2+) extrusion by promoting PMCA tyrosine phosphorylation.	Tyrosine	112-120	G protein-coupled estrogen receptor 1	Homo sapiens	30-34
26131713-3	2015	However, tamoxifen not only exerts antiestrogenic activity, but also acts as full agonist on the G protein-coupled estrogen receptor (GPER).	Tamoxifen	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	97-132
26131713-3	2015	However, tamoxifen not only exerts antiestrogenic activity, but also acts as full agonist on the G protein-coupled estrogen receptor (GPER).	Tamoxifen	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	134-138
26088671-2	2015	G protein-coupled estrogen receptor (GPER) is activated by 17beta-estradiol and participates in functional crosstalk with other steroid receptors.	Estradiol	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	0-35
26088671-2	2015	G protein-coupled estrogen receptor (GPER) is activated by 17beta-estradiol and participates in functional crosstalk with other steroid receptors.	Estradiol	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
26225773-5	2015	Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway.	Estradiol	22-38	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
26225773-5	2015	Our results show that 17beta-estradiol (E2) and the selective ligand of GPER, namely G-1, induce the expression of SIRT1 through GPER and the subsequent activation of the EGFR/ERK/c-fos/AP-1 transduction pathway.	Estradiol	22-38	G protein-coupled estrogen receptor 1	Homo sapiens	129-133
25885794-9	2015	Results of pharmacological experiments revealed that the cytoprotective actions of estradiol were dependent on ERbeta and IGF1R receptor tyrosine kinase activity and independent of ERalpha and G protein-coupled estrogen receptor 1 (G protein coupled receptor 30).	Estradiol	83-92	G protein-coupled estrogen receptor 1	Homo sapiens	232-261
25805831-0	2015	Ca2+ channel subunit alpha 1D promotes proliferation and migration of endometrial cancer cells mediated by 17beta-estradiol via the G protein-coupled estrogen receptor.	Estradiol	107-123	G protein-coupled estrogen receptor 1	Homo sapiens	132-167
26030000-4	2015	Here, we demonstrate that in SkBr3 breast cancer and HepG2 hepatocarcinoma cells, 17beta-estradiol (E2) and the selective GPER ligand G-1 induce miR144 expression through GPER and the involvement of the PI3K/ERK1/2/Elk1 transduction pathway.	Estradiol	82-98	G protein-coupled estrogen receptor 1	Homo sapiens	171-175
25969534-10	2015	These results suggest that physiological concentrations of DHEA activate a GPER intracellular signaling cascade that increases pri-miR-21 transcription mediated at least in part by AP-1 and androgen receptor miR-21 promoter interaction.	Dehydroepiandrosterone	59-63	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
25413376-6	2015	In addition, we show that 17beta-oestradiol induces the ERK1/2 activation and increases c-Fos expression through GPR30 associated with ERbeta down-regulation in TCam-2 cell line.	Estradiol	26-43	G protein-coupled estrogen receptor 1	Homo sapiens	113-118
25990368-15	2015	GPER probably contributes to tamoxifen resistance via interaction with the tumor microenvironment in a beta1-integrin-dependent pattern.	Tamoxifen	29-38	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
26359098-0	2015	[GPER silence inhibits the stimulation of growth and inhibition of apoptosis induced by tamoxifen in breast cancer-associated fibroblasts].	Tamoxifen	88-97	G protein-coupled estrogen receptor 1	Homo sapiens	1-5
26359098-8	2015	Tamoxifen promoted the growth of BCAFs, which could be attenuated by knockdown of GPER.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	82-86
26359098-9	2015	Moreover, the apoptosis of BCAFs was reduced by tamoxifen, which was also reversed by knockdown of GPER.	Tamoxifen	48-57	G protein-coupled estrogen receptor 1	Homo sapiens	99-103
26359098-11	2015	The ability of tamoxifen to accelerate cell proliferation and decrease cell apoptosis could be weakened by knockdown of GPER.	Tamoxifen	15-24	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
25969534-4	2015	siRNA, antibody, and inhibitor studies suggest that the rapid DHEA-mediated increase in miR-21 involves a G-protein-coupled estrogen receptor (GPER/GPR30), estrogen receptor alpha-36 (ERalpha36), epidermal growth factor receptor-dependent, pertussis toxin-sensitive pathway requiring activation of c-Src, ERK1/2, and PI3K.	Dehydroepiandrosterone	62-66	G protein-coupled estrogen receptor 1	Homo sapiens	143-147
25969534-4	2015	siRNA, antibody, and inhibitor studies suggest that the rapid DHEA-mediated increase in miR-21 involves a G-protein-coupled estrogen receptor (GPER/GPR30), estrogen receptor alpha-36 (ERalpha36), epidermal growth factor receptor-dependent, pertussis toxin-sensitive pathway requiring activation of c-Src, ERK1/2, and PI3K.	Dehydroepiandrosterone	62-66	G protein-coupled estrogen receptor 1	Homo sapiens	148-153
25969534-5	2015	GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription.	G-15	16-20	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25969534-5	2015	GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription.	Dehydroepiandrosterone	32-36	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25969534-5	2015	GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription.	Dehydroepiandrosterone	57-61	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25969534-7	2015	DHEA, like G-1, increased GPER and ERalpha36 mRNA and protein levels.	Dehydroepiandrosterone	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
25969534-8	2015	DHEA increased ERK1/2 and c-Src phosphorylation in a GPER-responsive manner.	Dehydroepiandrosterone	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	53-57
25990368-0	2015	Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and beta1-integrin signaling pathway in tumor cells.	Tamoxifen	66-75	G protein-coupled estrogen receptor 1	Homo sapiens	121-156
25990368-0	2015	Acquisition of epithelial-mesenchymal transition phenotype in the tamoxifen-resistant breast cancer cell: a new role for G protein-coupled estrogen receptor in mediating tamoxifen resistance through cancer-associated fibroblast-derived fibronectin and beta1-integrin signaling pathway in tumor cells.	Tamoxifen	170-179	G protein-coupled estrogen receptor 1	Homo sapiens	121-156
25990368-2	2015	beta1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estrogen receptor recognized as an initiator of tamoxifen resistance.	Tamoxifen	160-169	G protein-coupled estrogen receptor 1	Homo sapiens	60-95
25990368-2	2015	beta1-integrin was identified as one of the target genes of G protein-coupled estrogen receptor (GPER), a novel estrogen receptor recognized as an initiator of tamoxifen resistance.	Tamoxifen	160-169	G protein-coupled estrogen receptor 1	Homo sapiens	97-101
25990368-3	2015	Here, we investigated the role of beta1-integrin in GPER-mediated tamoxifen resistance in breast cancer.	Tamoxifen	66-75	G protein-coupled estrogen receptor 1	Homo sapiens	52-56
25847233-4	2015	In primary endothelial cells, GPER/GPR30 agonist G-1 decreases PMCA-mediated Ca(2+) extrusion by promoting PMCA tyrosine phosphorylation.	Tyrosine	112-120	G protein-coupled estrogen receptor 1	Homo sapiens	35-40
25847233-7	2015	GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1.	Estradiol	74-90	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25847233-7	2015	GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1.	Estradiol	74-90	G protein-coupled estrogen receptor 1	Homo sapiens	5-10
25847233-7	2015	GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1.	Thapsigargin	92-104	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25847233-7	2015	GPER/GPR30 co-immunoprecipitates with PMCA with or without treatment with 17beta-estradiol, thapsigargin, or G-1.	Thapsigargin	92-104	G protein-coupled estrogen receptor 1	Homo sapiens	5-10
25847233-13	2015	Activation of GPER/GPR30 further inhibits PMCA activity through tyrosine phosphorylation of the pump.	Tyrosine	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
25847233-13	2015	Activation of GPER/GPR30 further inhibits PMCA activity through tyrosine phosphorylation of the pump.	Tyrosine	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	19-24
25609836-10	2015	2-OHE2 also antagonized estrogen actions through GPER on cAMP production in zebrafish oocytes, resulting in a reduction in cAMP levels.	2-hydroxyestradiol	0-6	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
26175858-0	2015	G15 sensitizes epithelial breast cancer cells to doxorubicin by preventing epithelial-mesenchymal transition through inhibition of GPR30.	Doxorubicin	49-60	G protein-coupled estrogen receptor 1	Homo sapiens	131-136
25928008-0	2015	Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
25744245-0	2015	G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17beta-estradiol (E2) and selective agonist G1.	Estradiol	81-97	G protein-coupled estrogen receptor 1	Homo sapiens	0-35
25744245-0	2015	G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17beta-estradiol (E2) and selective agonist G1.	Estradiol	81-97	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
25744245-6	2015	Selective agonist G1 and 17beta-estradiol (E2) promoted the GPER-mediated proliferation, invasion, and migration of NSCLC cells.	Estradiol	25-41	G protein-coupled estrogen receptor 1	Homo sapiens	60-64
25744245-8	2015	Importantly, the pro-tumorigenic effects of GPER induced by E2 were significantly reduced by co-administering the GPER inhibitor G15 and the ERbeta inhibitor fulvestrant, as compared to administering fulvestrant alone both in vitro and in vivo.	Fulvestrant	158-169	G protein-coupled estrogen receptor 1	Homo sapiens	44-48
25823895-0	2015	17beta-estradiol inhibits spreading of metastatic cells from granulosa cell tumors through a non-genomic mechanism involving GPER1.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	125-130
25616260-3	2015	OBJECTIVES: We aimed to evaluate the potential of atrazine to trigger GPER-mediated signaling in cancer cells and cancer-associated fibroblasts (CAFs).	Atrazine	50-58	G protein-coupled estrogen receptor 1	Homo sapiens	70-74
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
25616260-5	2015	Conversely, atrazine was able to bind to GPER to induce ERK activation and the expression of estrogen target genes, which, interestingly, appeared to rely on both GPER and ERalpha expression.	Atrazine	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	163-167
25616260-6	2015	As a biological counterpart, atrazine stimulated the proliferation of ovarian cancer cells that depend on GPER and ERalpha, as evidenced by gene silencing experiments and the use of specific signaling inhibitors.	Atrazine	29-37	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
25616260-7	2015	Of note, through GPER, atrazine elicited ERK phosphorylation, gene expression, and migration in CAFs, thus extending its stimulatory role to these main players of the tumor microenvironment.	Atrazine	23-31	G protein-coupled estrogen receptor 1	Homo sapiens	17-21
25616260-9	2015	On the basis of our data, atrazine should be included among the environmental contaminants that may elicit estrogenic activity through GPER-mediated signaling.	Atrazine	26-34	G protein-coupled estrogen receptor 1	Homo sapiens	135-139
25647524-7	2015	Moreover, knockdown of GPER in CAFs suppressed breast cancer cell invasion induced by CAF conditioned media (CM).	caf conditioned media	86-107	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
25672442-5	2015	Furthermore, baicalein interfered with E2-induced novel G protein-coupled estrogen receptor (GPR30)-related signaling, including a decrease in tyrosine phosphorylation of epidermal growth factor receptor (EGFR) as well as phosphorylation of extracellular signal-regulated kinase (ERK) and serine/threonine kinase Akt, without affecting GPR30 expression.	baicalein	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	93-98
25672442-5	2015	Furthermore, baicalein interfered with E2-induced novel G protein-coupled estrogen receptor (GPR30)-related signaling, including a decrease in tyrosine phosphorylation of epidermal growth factor receptor (EGFR) as well as phosphorylation of extracellular signal-regulated kinase (ERK) and serine/threonine kinase Akt, without affecting GPR30 expression.	baicalein	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	336-341
25672442-5	2015	Furthermore, baicalein interfered with E2-induced novel G protein-coupled estrogen receptor (GPR30)-related signaling, including a decrease in tyrosine phosphorylation of epidermal growth factor receptor (EGFR) as well as phosphorylation of extracellular signal-regulated kinase (ERK) and serine/threonine kinase Akt, without affecting GPR30 expression.	Tyrosine	143-151	G protein-coupled estrogen receptor 1	Homo sapiens	93-98
25781607-9	2015	Inhibiting GPR30 through treatment with the G-15 antagonist or specific shRNA impaired E2 effects.	G-15	44-48	G protein-coupled estrogen receptor 1	Homo sapiens	11-16
25609836-10	2015	2-OHE2 also antagonized estrogen actions through GPER on cAMP production in zebrafish oocytes, resulting in a reduction in cAMP levels.	Cyclic AMP	57-61	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
25609836-10	2015	2-OHE2 also antagonized estrogen actions through GPER on cAMP production in zebrafish oocytes, resulting in a reduction in cAMP levels.	Cyclic AMP	123-127	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
26416628-3	2015	We incubated them with 17-beta estradiol (E(2)), after blocking, or upregulating, expression of GPER-1 with ICI182,780 (a GPER-1 agonist) and siGPR30, respectively.	Estradiol	23-40	G protein-coupled estrogen receptor 1	Homo sapiens	96-102
25395619-10	2015	In the discovery cohort, GPER P16L genotype was associated with a significant increase in LDL cholesterol (mean+-SEM): 3.18+-0.05, 3.25+-0.08, and 4.25+-0.33 mmol/L, respectively, in subjects with CC (homozygous for P16), CT (heterozygotes), and TT (homozygous for L16) genotypes (P&lt;0.05).	Cholesterol	94-105	G protein-coupled estrogen receptor 1	Homo sapiens	25-29
25395619-11	2015	In the validation cohort (n=339), the GPER P16L genotype was associated with a similar increase in LDL cholesterol: 2.17+-0.05, 2.34+-0.06, and 2.42+-0.16 mmol/L, respectively, in subjects with CC, CT, and TT genotypes (P&lt;0.05).	Cholesterol	103-114	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
25395619-11	2015	In the validation cohort (n=339), the GPER P16L genotype was associated with a similar increase in LDL cholesterol: 2.17+-0.05, 2.34+-0.06, and 2.42+-0.16 mmol/L, respectively, in subjects with CC, CT, and TT genotypes (P&lt;0.05).	Carbon Tetrachloride	198-200	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
25395619-15	2015	Furthermore, humans carrying the hypofunctional P16L genetic variant of GPER have increased plasma LDL cholesterol.	Cholesterol	103-114	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
25786510-0	2015	(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells.	(6-bromo-1,4-dimethyl-9H-carbazol-3-ylmethylene)hydrazine	1-59	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
25786510-0	2015	(6-bromo-1,4-dimethyl-9H-carbazol-3-yl-methylene)-hydrazine (carbhydraz) acts as a GPER agonist in breast cancer cells.	(6-bromo-1,4-dimethyl-9H-carbazol-3-ylmethylene)hydrazine	61-71	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
25786510-4	2015	In the present study, we designed and synthesized two novel carbazole derivatives and then investigated their ability to interact with and activate the GPER-mediated transduction pathway in breast cancer cells.	carbazole	60-69	G protein-coupled estrogen receptor 1	Homo sapiens	152-156
25875871-0	2015	Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts.	benzopyrroloxazines	22-41	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
25875871-3	2015	RESULTS: Two novel selective GPER antagonists, based on a benzo[b]pyrrolo[1,2-d][1,4]oxazin-4-one structure, have been designed and synthesized.	benzo[b]pyrrolo[1,2-d][1,4]oxazin-4-one	58-97	G protein-coupled estrogen receptor 1	Homo sapiens	29-33
25666016-4	2015	Tamoxifen resistance is associated with altered estrogen receptor expression especially on the plasma membrane, including the alternative G-protein coupled receptor GPR-30 (GPER) and estrogen receptor splice products, such as ERalpha36.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	165-171
25666016-4	2015	Tamoxifen resistance is associated with altered estrogen receptor expression especially on the plasma membrane, including the alternative G-protein coupled receptor GPR-30 (GPER) and estrogen receptor splice products, such as ERalpha36.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	173-177
26416628-8	2015	ICI182,780 enhanced E(2)-induced proliferation of LC (p &lt; 0.01), while knock down of the GPER-1 gene with GPER-1 small interfering RNA partially inhibited E(2)-induced cell proliferation (p &lt; 0.01).	Estradiol	158-162	G protein-coupled estrogen receptor 1	Homo sapiens	92-98
26416628-8	2015	ICI182,780 enhanced E(2)-induced proliferation of LC (p &lt; 0.01), while knock down of the GPER-1 gene with GPER-1 small interfering RNA partially inhibited E(2)-induced cell proliferation (p &lt; 0.01).	Estradiol	158-162	G protein-coupled estrogen receptor 1	Homo sapiens	109-115
25496649-0	2014	Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17beta-estradiol.	Estriol	23-30	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
25587872-3	2015	Furthermore, we explored GPER/GPR30"s molecular recognition properties by using reported agonist ligands (G1, estradiol (E2), tamoxifen, and fulvestrant) and the antagonist ligands (G15 and G36) in subsequent docking studies.	Estradiol	110-119	G protein-coupled estrogen receptor 1	Homo sapiens	25-29
25587872-3	2015	Furthermore, we explored GPER/GPR30"s molecular recognition properties by using reported agonist ligands (G1, estradiol (E2), tamoxifen, and fulvestrant) and the antagonist ligands (G15 and G36) in subsequent docking studies.	Estradiol	110-119	G protein-coupled estrogen receptor 1	Homo sapiens	30-35
25587872-3	2015	Furthermore, we explored GPER/GPR30"s molecular recognition properties by using reported agonist ligands (G1, estradiol (E2), tamoxifen, and fulvestrant) and the antagonist ligands (G15 and G36) in subsequent docking studies.	Tamoxifen	126-135	G protein-coupled estrogen receptor 1	Homo sapiens	25-29
25587872-4	2015	Our results identified the E2 binding site on GPER/GPR30, as well as other receptor cavities for accepting large volume ligands, through GPER/GPR30 pi-pi, hydrophobic, and hydrogen bond interactions.	Hydrogen	172-180	G protein-coupled estrogen receptor 1	Homo sapiens	46-50
25587872-4	2015	Our results identified the E2 binding site on GPER/GPR30, as well as other receptor cavities for accepting large volume ligands, through GPER/GPR30 pi-pi, hydrophobic, and hydrogen bond interactions.	Hydrogen	172-180	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
26281354-3	2015	Effects of GPER include activation of MAPK and PI3K signaling pathways, stimulation of adenyl cyclase, and mobilization of calcium ions from intracellular stores, as well as upregulation of genes such as FOS and CTGF.	Calcium	123-130	G protein-coupled estrogen receptor 1	Homo sapiens	11-15
26281354-5	2015	Antiestrogens tamoxifen, raloxifene, or fulvestrant proved,to be agonists of GPER, which undoubtedly is not without significance for the efficacy of the therapy.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
26281354-5	2015	Antiestrogens tamoxifen, raloxifene, or fulvestrant proved,to be agonists of GPER, which undoubtedly is not without significance for the efficacy of the therapy.	Raloxifene Hydrochloride	25-35	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
26281354-5	2015	Antiestrogens tamoxifen, raloxifene, or fulvestrant proved,to be agonists of GPER, which undoubtedly is not without significance for the efficacy of the therapy.	Fulvestrant	40-51	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
25496649-0	2014	Inhibition of GPR30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17beta-estradiol.	Estradiol	101-117	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
25496649-3	2014	We have recently shown that knock-down of GPR30 expression prevented growth stimulation of TNBC cell lines by 17beta-estradiol.	Estradiol	110-126	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
25167221-0	2014	GPER-1 and estrogen receptor-beta ligands modulate aldosterone synthesis.	Aldosterone	51-62	G protein-coupled estrogen receptor 1	Homo sapiens	0-33
25030373-3	2014	Here, we developed (99m)Tc-labeled GPER ligands to demonstrate the in vivo status of GPER as an estrogen receptor (ER) and for GPER visualization in whole animals.	Technetium	24-26	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
25030373-3	2014	Here, we developed (99m)Tc-labeled GPER ligands to demonstrate the in vivo status of GPER as an estrogen receptor (ER) and for GPER visualization in whole animals.	Technetium	24-26	G protein-coupled estrogen receptor 1	Homo sapiens	85-89
25030373-3	2014	Here, we developed (99m)Tc-labeled GPER ligands to demonstrate the in vivo status of GPER as an estrogen receptor (ER) and for GPER visualization in whole animals.	Technetium	24-26	G protein-coupled estrogen receptor 1	Homo sapiens	85-89
25030373-9	2014	In conclusion, we synthesized and evaluated a series of first-generation (99m)Tc-labeled GPER-specific radioligands, demonstrating GPER as an estrogen-binding receptor for the first time in vivo using competitive binding principles, and establishing the utility of such ligands as tumor imaging agents.	Technetium	78-80	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
25030373-9	2014	In conclusion, we synthesized and evaluated a series of first-generation (99m)Tc-labeled GPER-specific radioligands, demonstrating GPER as an estrogen-binding receptor for the first time in vivo using competitive binding principles, and establishing the utility of such ligands as tumor imaging agents.	Technetium	78-80	G protein-coupled estrogen receptor 1	Homo sapiens	131-135
24894716-4	2014	We demonstrated that 17beta-estradiol (E2) and the GPER-selective ligand G-1 triggered a GPER/EGFR/ERK/c-fos signaling pathway that leads to increased VEGF via upregulation of HIF1alpha.	Estradiol	21-37	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
25312822-0	2014	Bisphenol A stimulates human lung cancer cell migration via upregulation of matrix metalloproteinases by GPER/EGFR/ERK1/2 signal pathway.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
25012984-5	2014	Moreover, cell migration triggered by insulin occurred through GPER1 and its main target gene CTGF, whereas the insulin-induced expression of GPER1 boosted cell-cycle progression and the glucose uptake stimulated by estrogens.	Glucose	187-194	G protein-coupled estrogen receptor 1	Homo sapiens	142-147
24874276-0	2014	GPER mediates enhanced cell viability and motility via non-genomic signaling induced by 17beta-estradiol in triple-negative breast cancer cells.	Estradiol	88-104	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
24874276-6	2014	Treatment with 17beta-estradiol (E2), the GPER-specific agonist G-1 and tamoxifen (TAM) led to rapid activation of p-ERK1/2, but not p-Akt.	Estradiol	15-31	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
24874276-6	2014	Treatment with 17beta-estradiol (E2), the GPER-specific agonist G-1 and tamoxifen (TAM) led to rapid activation of p-ERK1/2, but not p-Akt.	Tamoxifen	72-81	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
25005496-0	2014	G protein-coupled estrogen receptor 1 mediates relaxation of coronary arteries via cAMP/PKA-dependent activation of MLCP.	Cyclic AMP	83-87	G protein-coupled estrogen receptor 1	Homo sapiens	0-37
25005496-3	2014	In the current study, we tested the hypothesis that GPER-induced relaxation of porcine coronary arteries is mediated via cAMP/PKA signaling.	Cyclic AMP	121-125	G protein-coupled estrogen receptor 1	Homo sapiens	52-56
25005496-4	2014	Our findings revealed that vascular relaxation to the selective GPER agonist G-1 (0.3-3 muM) was associated with increased cAMP production in a concentration-dependent manner.	Cyclic AMP	123-127	G protein-coupled estrogen receptor 1	Homo sapiens	64-68
25005496-12	2014	These findings demonstrate that localized cAMP/PKA signaling is involved in GPER-mediated coronary vasodilation by activating MLCP via inhibition of RhoA pathway.	Cyclic AMP	42-46	G protein-coupled estrogen receptor 1	Homo sapiens	76-80
25312822-5	2014	G-protein-coupled estrogen receptor (GPER), while not estrogen receptor alpha/beta (ERalpha/beta), mediated the BPA induced up regulation of MMPs.	bisphenol A	112-115	G protein-coupled estrogen receptor 1	Homo sapiens	0-35
25312822-5	2014	G-protein-coupled estrogen receptor (GPER), while not estrogen receptor alpha/beta (ERalpha/beta), mediated the BPA induced up regulation of MMPs.	bisphenol A	112-115	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
25312822-6	2014	Further, BPA treatment induced rapid activation of ERK1/2 via GPER/EGFR.	bisphenol A	9-12	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
25312822-7	2014	GPER/ERFR/ERK1/2 mediated the BPA induced upregulation of MMPs and in vitro migration of lung cancer A549 cells.	bisphenol A	30-33	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25312822-8	2014	In summary, our data presented here revealed for the first time that BPA can promote the in vitro migration and invasion of lung cancer cells via upregulation of MMPs and GPER/EGFR/ERK1/2 signals, which mediated these effects.	bisphenol A	69-72	G protein-coupled estrogen receptor 1	Homo sapiens	171-175
24874276-6	2014	Treatment with 17beta-estradiol (E2), the GPER-specific agonist G-1 and tamoxifen (TAM) led to rapid activation of p-ERK1/2, but not p-Akt.	Tamoxifen	83-86	G protein-coupled estrogen receptor 1	Homo sapiens	42-46
24928526-0	2014	Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	18-22
24928526-0	2014	Tamoxifen through GPER upregulates aromatase expression: a novel mechanism sustaining tamoxifen-resistant breast cancer cell growth.	Tamoxifen	86-95	G protein-coupled estrogen receptor 1	Homo sapiens	18-22
24928526-8	2014	This is mediated by the G-protein-coupled receptor GPR30/GPER, since knocking-down GPER expression or treatment with a GPER antagonist reversed the enhanced aromatase levels induced by long-term tamoxifen exposure.	Tamoxifen	195-204	G protein-coupled estrogen receptor 1	Homo sapiens	51-56
24928526-8	2014	This is mediated by the G-protein-coupled receptor GPR30/GPER, since knocking-down GPER expression or treatment with a GPER antagonist reversed the enhanced aromatase levels induced by long-term tamoxifen exposure.	Tamoxifen	195-204	G protein-coupled estrogen receptor 1	Homo sapiens	57-61
24928526-8	2014	This is mediated by the G-protein-coupled receptor GPR30/GPER, since knocking-down GPER expression or treatment with a GPER antagonist reversed the enhanced aromatase levels induced by long-term tamoxifen exposure.	Tamoxifen	195-204	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
24928526-8	2014	This is mediated by the G-protein-coupled receptor GPR30/GPER, since knocking-down GPER expression or treatment with a GPER antagonist reversed the enhanced aromatase levels induced by long-term tamoxifen exposure.	Tamoxifen	195-204	G protein-coupled estrogen receptor 1	Homo sapiens	83-87
24928526-9	2014	The molecular mechanism was investigated in ER-negative, GPER/aromatase-positive SKBR3 cells, in which tamoxifen acts as a GPER agonist.	Tamoxifen	103-112	G protein-coupled estrogen receptor 1	Homo sapiens	57-61
24928526-9	2014	The molecular mechanism was investigated in ER-negative, GPER/aromatase-positive SKBR3 cells, in which tamoxifen acts as a GPER agonist.	Tamoxifen	103-112	G protein-coupled estrogen receptor 1	Homo sapiens	123-127
24928526-11	2014	As tamoxifen via GPER induced aromatase expression also in CAFs, this pathway may be involved in promoting aggressive behavior of breast tumors in response to tamoxifen treatment.	Tamoxifen	3-12	G protein-coupled estrogen receptor 1	Homo sapiens	17-21
24928526-11	2014	As tamoxifen via GPER induced aromatase expression also in CAFs, this pathway may be involved in promoting aggressive behavior of breast tumors in response to tamoxifen treatment.	Tamoxifen	159-168	G protein-coupled estrogen receptor 1	Homo sapiens	17-21
24662263-0	2014	Niacin activates the G protein estrogen receptor (GPER)-mediated signalling.	Niacin	0-6	G protein-coupled estrogen receptor 1	Homo sapiens	21-48
24662263-0	2014	Niacin activates the G protein estrogen receptor (GPER)-mediated signalling.	Niacin	0-6	G protein-coupled estrogen receptor 1	Homo sapiens	50-54
24662263-4	2014	In the present study, we demonstrate for the first time that nicotinic acid and nicotinamide bind to and activate the GPER-mediated signalling in breast cancer cells and cancer-associated fibroblasts (CAFs).	Niacin	61-75	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
24662263-4	2014	In the present study, we demonstrate for the first time that nicotinic acid and nicotinamide bind to and activate the GPER-mediated signalling in breast cancer cells and cancer-associated fibroblasts (CAFs).	Niacinamide	80-92	G protein-coupled estrogen receptor 1	Homo sapiens	118-122
24662263-6	2014	As a biological counterpart, nicotinic acid and nicotinamide induce proliferative and migratory effects in breast cancer cells and CAFs in a GPER-dependent fashion.	Niacin	29-43	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
24662263-6	2014	As a biological counterpart, nicotinic acid and nicotinamide induce proliferative and migratory effects in breast cancer cells and CAFs in a GPER-dependent fashion.	Niacinamide	48-60	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
24662263-7	2014	Moreover, nicotinic acid prevents the up-regulation of ICAM-1 triggered by the pro-inflammatory cytokine TNF-alpha and stimulates the formation of endothelial tubes through GPER in HUVECs.	Niacin	10-24	G protein-coupled estrogen receptor 1	Homo sapiens	173-177
24662263-8	2014	Together, our findings concerning the agonist activity for GPER displayed by both nicotinic acid and nicotinamide broaden the mechanisms involved in the biological action of these molecules and further support the potential of a ligand to induce different responses mediated in a promiscuous manner by distinct GPCRs.	Niacin	82-96	G protein-coupled estrogen receptor 1	Homo sapiens	59-63
24662263-8	2014	Together, our findings concerning the agonist activity for GPER displayed by both nicotinic acid and nicotinamide broaden the mechanisms involved in the biological action of these molecules and further support the potential of a ligand to induce different responses mediated in a promiscuous manner by distinct GPCRs.	Niacinamide	101-113	G protein-coupled estrogen receptor 1	Homo sapiens	59-63
24928526-12	2014	Blocking estrogen production and/or GPER signaling activation may represent a valid option to overcome tamoxifen-resistance in breast cancers.	Tamoxifen	103-112	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
24715381-2	2014	Tamoxifen is a partial agonist at GPER in vitro.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	34-38
24718680-0	2014	Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway.	icariin	0-7	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
24718680-0	2014	Icariin and icaritin stimulate the proliferation of SKBr3 cells through the GPER1-mediated modulation of the EGFR-MAPK signaling pathway.	icaritin	12-20	G protein-coupled estrogen receptor 1	Homo sapiens	76-81
24718680-4	2014	The ICA- and ICT-stimulated cell growth was completely suppressed by the GPER1 antagonist, G-15, indicating that the ICA- and ICT-stimulated cell proliferation was mediated by GPER1 activation.	icariin	4-7	G protein-coupled estrogen receptor 1	Homo sapiens	73-78
24718680-4	2014	The ICA- and ICT-stimulated cell growth was completely suppressed by the GPER1 antagonist, G-15, indicating that the ICA- and ICT-stimulated cell proliferation was mediated by GPER1 activation.	icariin	4-7	G protein-coupled estrogen receptor 1	Homo sapiens	176-181
24718680-9	2014	Flow cytometric analysis confirmed that the ICA- and ICT-stimulated SKBr3 cell proliferation involved the GPER1-mediated modulation of the EGFR-MAPK signaling pathway.	icariin	44-47	G protein-coupled estrogen receptor 1	Homo sapiens	106-111
24796498-4	2014	Vasodilation induced by G-1 (selective GPER-agonist, 3 muM) from HRAs pre-contracted with norepinephrine amounted to 40+-5% in PMW, significantly larger than those obtained from M (20+-5%) or PGW (20+-5%).	Norepinephrine	90-104	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
24796498-5	2014	L-NAME (nitric oxide (NO) synthase inhibitor) abolished these relaxations in PGW, attenuated them in PMW and had no effect in M. Immunohistochemical analysis confirmed the presence of GPER in both smooth muscle and endothelial cells of HRA with maximum expression in PGW.	NG-Nitroarginine Methyl Ester	0-6	G protein-coupled estrogen receptor 1	Homo sapiens	184-188
24796498-5	2014	L-NAME (nitric oxide (NO) synthase inhibitor) abolished these relaxations in PGW, attenuated them in PMW and had no effect in M. Immunohistochemical analysis confirmed the presence of GPER in both smooth muscle and endothelial cells of HRA with maximum expression in PGW.	Nitric Oxide	8-20	G protein-coupled estrogen receptor 1	Homo sapiens	184-188
24704272-1	2014	In this study, we investigated the role of GPR30 in 17beta-estradiol- (E2) mediated neuroprotection after an ischemic injury in an organotypic hippocampal slice culture (OHSC) model.	Estradiol	52-68	G protein-coupled estrogen receptor 1	Homo sapiens	43-48
24704272-3	2014	The canonical estrogen receptor (ER) inhibitor ICI 182,780 completely abrogated the therapeutic effect of E2 while the GPR30 antagonist G-15 effected a slight but not significant reduction in neuroprotection.	G-15	136-140	G protein-coupled estrogen receptor 1	Homo sapiens	119-124
24834064-3	2014	A wide number of natural and synthetic compounds, including estrogens and anti-estrogens, elicit stimulatory effects in breast cancer through GPER up-regulation and activation, suggesting that GPER function is associated with breast tumor progression and tamoxifen resistance.	Tamoxifen	255-264	G protein-coupled estrogen receptor 1	Homo sapiens	193-197
24718936-8	2014	Inhibition of candidate signaling pathways that may link GPER activation to proliferation revealed a dependence on Src, epidermal growth factor receptor transactivation by heparin-bound EGF and subsequent ERK phosphorylation.	Heparin	172-179	G protein-coupled estrogen receptor 1	Homo sapiens	57-61
24715381-6	2014	In the tamoxifen-treated ER-positive and progesterone receptor (PgR)-positive patient subgroup, the absence of PM GPER (53 % of all ER-positive tumors) predicted 91 % 20-year distant disease-free survival, compared to 73 % in the presence of GPER (p = 0.001).	Tamoxifen	7-16	G protein-coupled estrogen receptor 1	Homo sapiens	114-118
24446390-10	2014	Small interfering RNA targeting GPER or G protein inhibitor pertussin toxin (PTX) inhibited basal cell proliferation and attenuated 17beta-estradiol- or G-1-induced cell proliferation.	Estradiol	132-148	G protein-coupled estrogen receptor 1	Homo sapiens	32-36
24715381-9	2014	GPER overexpression and PM localization are critical events in breast cancer progression, and lack of GPER in the PM is associated with excellent long-term prognosis in ER-positive and PgR-positive tamoxifen-treated primary breast cancer.	Tamoxifen	198-207	G protein-coupled estrogen receptor 1	Homo sapiens	102-106
24446390-0	2014	A novel estrogen receptor GPER mediates proliferation induced by 17beta-estradiol and selective GPER agonist G-1 in estrogen receptor alpha (ERalpha)-negative ovarian cancer cells.	Estradiol	65-81	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
24736568-0	2014	Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis.	Testosterone	68-80	G protein-coupled estrogen receptor 1	Homo sapiens	14-20
24908729-0	2014	[Low-dose nonylphenol promotes the proliferation of DU-145 cells and expression of membrane estrogen receptor GPR30 in DU-145 cells].	nonylphenol	10-21	G protein-coupled estrogen receptor 1	Homo sapiens	110-115
24908729-1	2014	OBJECTIVE: To observe the effects of low-dose exogenous estrogen nonylphenol (NP) on the proliferation of human prostate cancer cell lines DU-145 and the expression of the membrane estrogen receptor GPR30 in the DU-145 cells.	nonylphenol	65-76	G protein-coupled estrogen receptor 1	Homo sapiens	199-204
24525372-4	2014	Moreover, both anti-collagenogenic and pro-elastogenic effects of tanshinone IIA occurred only after selective activation of the G protein-coupled estrogen receptor (GPER).	tanshinone	66-80	G protein-coupled estrogen receptor 1	Homo sapiens	129-164
24525372-4	2014	Moreover, both anti-collagenogenic and pro-elastogenic effects of tanshinone IIA occurred only after selective activation of the G protein-coupled estrogen receptor (GPER).	tanshinone	66-80	G protein-coupled estrogen receptor 1	Homo sapiens	166-170
24736568-14	2014	The expression of GPER-1 in human testis, which lack ERalpha, makes it an exciting target for developing new agents affecting testosterone production in men.	Testosterone	126-138	G protein-coupled estrogen receptor 1	Homo sapiens	18-24
24440569-6	2014	E2 and ICI also induced phosphorylation of extracellular regulated protein kinases 1 and 2 (ERK1/2), and suppression of ERK1/2 phosphorylation by U0126 profoundly impeded calpain activation triggered by estrogenic and antiestrogenic stimulations indicating implication of ERK1/2 in the GPR30-mediated action.	U 0126	146-151	G protein-coupled estrogen receptor 1	Homo sapiens	286-291
24481325-6	2014	Tamoxifen (TAM) in addition to 17beta-estradiol (E2) and the GPER agonist G1 activated GPER, resulting in transient increases in cell index, intracellular calcium, and ERK1/2 phosphorylation.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
24481325-6	2014	Tamoxifen (TAM) in addition to 17beta-estradiol (E2) and the GPER agonist G1 activated GPER, resulting in transient increases in cell index, intracellular calcium, and ERK1/2 phosphorylation.	Tamoxifen	11-14	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
24481325-6	2014	Tamoxifen (TAM) in addition to 17beta-estradiol (E2) and the GPER agonist G1 activated GPER, resulting in transient increases in cell index, intracellular calcium, and ERK1/2 phosphorylation.	Estradiol	49-51	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
24481325-6	2014	Tamoxifen (TAM) in addition to 17beta-estradiol (E2) and the GPER agonist G1 activated GPER, resulting in transient increases in cell index, intracellular calcium, and ERK1/2 phosphorylation.	Calcium	155-162	G protein-coupled estrogen receptor 1	Homo sapiens	61-65
24481325-7	2014	Furthermore, TAM, E2, and G1 promoted CAF proliferation and cell-cycle progression, both of which were blocked by GPER interference, the selective GPER antagonist G15, the epidermal growth factor receptor (EGFR) inhibitor AG1478, and the ERK1/2 inhibitor U0126.	RTKI cpd	222-228	G protein-coupled estrogen receptor 1	Homo sapiens	114-118
24481325-7	2014	Furthermore, TAM, E2, and G1 promoted CAF proliferation and cell-cycle progression, both of which were blocked by GPER interference, the selective GPER antagonist G15, the epidermal growth factor receptor (EGFR) inhibitor AG1478, and the ERK1/2 inhibitor U0126.	U 0126	255-260	G protein-coupled estrogen receptor 1	Homo sapiens	114-118
24481325-8	2014	Importantly, TAM as well as G1 increased E2 production in breast CAFs via GPER/EGFR/ERK signaling when the substrate of E2, testosterone, was added to the medium.	Tamoxifen	13-16	G protein-coupled estrogen receptor 1	Homo sapiens	74-78
24481325-8	2014	Importantly, TAM as well as G1 increased E2 production in breast CAFs via GPER/EGFR/ERK signaling when the substrate of E2, testosterone, was added to the medium.	Testosterone	124-136	G protein-coupled estrogen receptor 1	Homo sapiens	74-78
24481325-9	2014	GPER-induced aromatase upregulation was probably responsible for this phenomenon, as TAM- and G1-induced CYP19A1 gene expression was reduced by GPER knockdown and G15, AG1478, and U0126 administration.	U 0126	180-185	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
24481325-10	2014	Accordingly, GPER-mediated CAF-dependent estrogenic effects on the tumor-associated stroma are conceivable, and CAF is likely to contribute to breast cancer progression, especially TAM resistance, via a positive feedback loop involving GPER/EGFR/ERK signaling and E2 production.	Tamoxifen	181-184	G protein-coupled estrogen receptor 1	Homo sapiens	236-240
24019118-0	2014	Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.	3,4-dihydroxyphenylethanol	15-29	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
24019118-0	2014	Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells.	3,4-dihydroxyphenylethanol	15-29	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
24019118-5	2014	MTT cell proliferation assays revealed that both phenols reduced SKBR3 cell growth; this effect was abolished silencing GPER.	monooxyethylene trimethylolpropane tristearate	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
24019118-5	2014	MTT cell proliferation assays revealed that both phenols reduced SKBR3 cell growth; this effect was abolished silencing GPER.	Phenols	49-56	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
24239983-5	2014	Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding.	Estradiol	166-182	G protein-coupled estrogen receptor 1	Homo sapiens	105-111
24239983-5	2014	Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding.	Estradiol	166-182	G protein-coupled estrogen receptor 1	Homo sapiens	113-123
24239983-5	2014	Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding.	Aldosterone	227-238	G protein-coupled estrogen receptor 1	Homo sapiens	113-123
24239983-5	2014	Plasma membrane fractions prepared from whole kidney tissue or HEK293 cells expressing recombinant human GPER-1 (HEK-GPER-1) displayed high-affinity, specific [(3)H]-17beta-estradiol ([(3)H]-E2) binding, but no specific [(3)H]-aldosterone binding.	Aldosterone	227-238	G protein-coupled estrogen receptor 1	Homo sapiens	105-111
24275097-1	2014	The G protein-coupled receptor GPR30/GPER has been shown to mediate rapid effects of 17beta-estradiol (E2) in diverse types of cancer cells.	Estradiol	85-101	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
24451139-5	2014	In order to explain this overexpression, we investigated the possible association of polymorphisms in the GPER gene by using allele-specific tetra-primer polymerase chain reaction performed on tissue samples from 150 paraffin-embedded TGCT specimens (131 seminomas, 19 non seminomas).	Paraffin	217-225	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
24421881-1	2014	INTRODUCTION: The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen.	Tamoxifen	158-167	G protein-coupled estrogen receptor 1	Homo sapiens	18-53
24421881-1	2014	INTRODUCTION: The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor that mediates proliferative effects induced by estrogen but also by tamoxifen.	Tamoxifen	158-167	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
24486480-0	2014	Retraction: G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	123-131	G protein-coupled estrogen receptor 1	Homo sapiens	12-41
24275097-1	2014	The G protein-coupled receptor GPR30/GPER has been shown to mediate rapid effects of 17beta-estradiol (E2) in diverse types of cancer cells.	Estradiol	85-101	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
23902478-5	2013	G-Protein oestrogen receptor (GPER) is a recently recognized G-protein coupled receptor (GPCR) that is activated by steroid hormones.	Steroids	116-132	G protein-coupled estrogen receptor 1	Homo sapiens	0-28
23902478-5	2013	G-Protein oestrogen receptor (GPER) is a recently recognized G-protein coupled receptor (GPCR) that is activated by steroid hormones.	Steroids	116-132	G protein-coupled estrogen receptor 1	Homo sapiens	30-34
23902478-7	2013	Activation of GPER also mediates at least some of the vascular effects of aldosterone in smooth muscle and endothelial cells.	Aldosterone	74-85	G protein-coupled estrogen receptor 1	Homo sapiens	14-18
23907016-0	2013	17beta-estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	138-143
24169358-0	2013	Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex.	Fulvestrant	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	45-49
23959105-7	2013	Typical serum BPA concentrations are orders of magnitude lower than levels measurable by modern analytical methods and below concentrations required to occupy more than 0.0009% of Type II Estrogen Binding Sites, GPR30, ERalpha or ERbeta receptors.	bisphenol A	14-17	G protein-coupled estrogen receptor 1	Homo sapiens	212-217
24289103-0	2013	GPR30 as an initiator of tamoxifen resistance in hormone-dependent breast cancer.	Tamoxifen	25-34	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
24289103-2	2013	Here, we investigated the role of estrogen G-protein coupled receptor 30 (GPR30) on Tamoxifen resistance in breast cancer.	Tamoxifen	84-93	G protein-coupled estrogen receptor 1	Homo sapiens	43-72
24289103-2	2013	Here, we investigated the role of estrogen G-protein coupled receptor 30 (GPR30) on Tamoxifen resistance in breast cancer.	Tamoxifen	84-93	G protein-coupled estrogen receptor 1	Homo sapiens	74-79
24289103-8	2013	In TAM-R cells, GPR30 cell-surface translocation facilitated crosstalk with EGFR, and reduced cAMP generation, attenuating inhibition of EGFR signaling.	Cyclic AMP	94-98	G protein-coupled estrogen receptor 1	Homo sapiens	16-21
23907016-3	2013	In this study, the main aims were focused on the potential role of GPER1 in regulating migration and invasion of nuclear estrogen receptor (ER)-negative breast cancer cells upon 17beta-estradiol (E2) stimulation and the involved signaling pathway.	Estradiol	178-194	G protein-coupled estrogen receptor 1	Homo sapiens	67-72
23755949-1	2013	OBJECTIVE: To investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endometriotic cells.	G-15	201-205	G protein-coupled estrogen receptor 1	Homo sapiens	178-182
23602294-0	2013	Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women.	Calcium	0-7	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
23602294-0	2013	Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women.	Cholesterol	46-57	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
24039841-0	2013	Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor alpha (ERalpha).	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
24039841-0	2013	Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor alpha (ERalpha).	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
24039841-2	2013	Previous reports have demonstrated that estradiol and tamoxifen induce proliferation of human endometrial cancer cells through GPR30 (non-genomic ER) signaling pathway.	Estradiol	40-49	G protein-coupled estrogen receptor 1	Homo sapiens	127-132
24039841-2	2013	Previous reports have demonstrated that estradiol and tamoxifen induce proliferation of human endometrial cancer cells through GPR30 (non-genomic ER) signaling pathway.	Tamoxifen	54-63	G protein-coupled estrogen receptor 1	Homo sapiens	127-132
24039841-3	2013	Herein, we demonstrate that phosphorylation of focal adhesion kinase (FAK) is involved in cell migration induced by estradiol, tamoxifen and G1 (a GPR30 agonist) through the transmembrane ER (GPR30) in endometrial cancer cell lines with or without ERalpha (Ishikawa and RL95-2).	Estradiol	116-125	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
24039841-3	2013	Herein, we demonstrate that phosphorylation of focal adhesion kinase (FAK) is involved in cell migration induced by estradiol, tamoxifen and G1 (a GPR30 agonist) through the transmembrane ER (GPR30) in endometrial cancer cell lines with or without ERalpha (Ishikawa and RL95-2).	Estradiol	116-125	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
24039841-3	2013	Herein, we demonstrate that phosphorylation of focal adhesion kinase (FAK) is involved in cell migration induced by estradiol, tamoxifen and G1 (a GPR30 agonist) through the transmembrane ER (GPR30) in endometrial cancer cell lines with or without ERalpha (Ishikawa and RL95-2).	Tamoxifen	127-136	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
24039841-3	2013	Herein, we demonstrate that phosphorylation of focal adhesion kinase (FAK) is involved in cell migration induced by estradiol, tamoxifen and G1 (a GPR30 agonist) through the transmembrane ER (GPR30) in endometrial cancer cell lines with or without ERalpha (Ishikawa and RL95-2).	Tamoxifen	127-136	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
23804203-0	2013	Resveratrol inhibits K(v)2.2 currents through the estrogen receptor GPR30-mediated PKC pathway.	Resveratrol	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
23804203-7	2013	Moreover, the effect of REV on K(v)2.2 was reduced by preincubation with antagonists of GPR30 receptor and shRNA for GPR30 receptor.	Resveratrol	24-27	G protein-coupled estrogen receptor 1	Homo sapiens	88-93
23804203-7	2013	Moreover, the effect of REV on K(v)2.2 was reduced by preincubation with antagonists of GPR30 receptor and shRNA for GPR30 receptor.	Resveratrol	24-27	G protein-coupled estrogen receptor 1	Homo sapiens	117-122
23755949-5	2013	INTERVENTION(S): Treatment with the histone deacetylase inhibitor romidepsin or suberoylanilide hydroxamic acid (SAHA), or with the GPER antagonist G-15.	G-15	148-152	G protein-coupled estrogen receptor 1	Homo sapiens	132-136
23755949-7	2013	Effects of GPER stimulation and inhibition on cell proliferation were investigated by the 93-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (Sigma) (MTT) assay.	93-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide	90-151	G protein-coupled estrogen receptor 1	Homo sapiens	11-15
23624423-0	2013	4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells.	hydroxytamoxifen	0-18	G protein-coupled estrogen receptor 1	Homo sapiens	69-98
23951246-7	2013	Although GPER was found to be specifically induced by LH/FSH, GPER agonists (4-Hydroxy-Tamoxifen, G1) reduced EOC cell proliferation only in case of LH/FSH unstimulated pathways.	4'-hydroxytamoxifen	77-96	G protein-coupled estrogen receptor 1	Homo sapiens	62-66
23624423-0	2013	4-Hydroxytamoxifen-stimulated processing of cyclin E is mediated via G protein-coupled receptor 30 (GPR30) and accompanied by enhanced migration in MCF-7 breast cancer cells.	hydroxytamoxifen	0-18	G protein-coupled estrogen receptor 1	Homo sapiens	100-105
23402905-0	2013	Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: evidence for involvement of GPR30/EGFR signaling pathway.	2-(piperidinoethoxyphenyl)-3-(4-hydroxyphenyl)-2H-benzo(b)pyran	27-90	G protein-coupled estrogen receptor 1	Homo sapiens	120-125
23840305-5	2013	We found that the GPER agonist, G-1, inhibited both human and porcine CASMC proliferation in a concentration- (10(-8) to 10(-5) M) and time-dependent manner.	casmc	70-75	G protein-coupled estrogen receptor 1	Homo sapiens	18-22
23840305-9	2013	CONCLUSION: GPER activation inhibits CASMC proliferation by suppressing cell cycle progression via inhibition of ERK1/2 and Akt phosphorylation.	casmc	37-42	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
23419549-0	2013	The key involvement of estrogen receptor beta and G-protein-coupled receptor 30 in the neuroprotective action of daidzein.	daidzein	113-121	G protein-coupled estrogen receptor 1	Homo sapiens	50-79
23615160-7	2013	Finally, given that certain clinically approved drugs such as SERM or SERDs (thought only to block or downregulate nuclear ERs) actually cause vasodilation through GPER and have been shown in recent clinical studies to provide cardiovascular protection in postmenopausal women, we may have to rethink our current understanding, concepts, and strategies of how to interfere with the increased risk of vascular disease in women with estrogen deficiency or after menopause.	serds	70-75	G protein-coupled estrogen receptor 1	Homo sapiens	164-168
23580092-2	2013	It has become apparent that GPER mediates the non-genomic signaling of 17beta-estradiol (E2) in a variety of estrogen-related cancers.	Estradiol	71-87	G protein-coupled estrogen receptor 1	Homo sapiens	28-32
23580092-9	2013	Small interfering RNA (siRNA) targeting GPER and G protein inhibitor pertussin toxin (PTX) inhibited the migration and invasion of OVCAR5 cells, and also reduced the expression and activity of MMP-9.	ptx	86-89	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
23554355-3	2013	EXPERIMENTAL DESIGN: GPER1 expression was analyzed by immunohistochemistry in breast tumors from 273 pre- and postmenopausal stage II patients, all treated with adjuvant tamoxifen for 2 years (cohort I) and from 208 premenopausal lymph node-negative patients, of which 87% were not subjected to any adjuvant systemic treatment (cohort II).	Tamoxifen	170-179	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
23085545-9	2013	GPR30 mediates rapid non-genomic effects to protect neurons against injury by inhibiting p-DAPK1 dephosphorylation, which inhibits NR2B subunit phosphorylation at Ser-1303.	Serine	163-166	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
23554355-8	2013	Treating HEK-R with the proteasome inhibitor epoxomicin, to decrease GPER1 degradation, further increases receptor-dependent proapoptotic signaling.	epoxomicin	45-55	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
23544495-0	2013	[Influence of pertussis toxin on GPER-mediated activation of phosphatidylinositol 3-kinase/protein kinase B signaling induced by 17beta-estradiol in endometrial carcinoma cells].	Estradiol	129-145	G protein-coupled estrogen receptor 1	Homo sapiens	33-37
23300088-1	2013	The estrogen 17beta-estradiol (E2) modulates dendritic spine plasticity in the cornu ammonis 1 (CA1) region of the hippocampus, and GPR30 (G-protein coupled estrogen receptor 1 (GPER1)) is an estrogen-sensitive G-protein-coupled receptor (GPCR) that is expressed in the mammalian brain and in specific subregions that are responsive to E2, including the hippocampus.	Estradiol	13-29	G protein-coupled estrogen receptor 1	Homo sapiens	139-176
23544495-1	2013	OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells.	Estradiol	217-233	G protein-coupled estrogen receptor 1	Homo sapiens	68-103
23544495-1	2013	OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells.	Estradiol	217-233	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
23544495-1	2013	OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells.	17beta-e2	235-244	G protein-coupled estrogen receptor 1	Homo sapiens	68-103
23544495-1	2013	OBJECTIVE: To investigate the influence of pertussis toxin (PTX) on G protein-coupled estrogen receptor (GPER)-mediated activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling activated by 17beta-estradiol (17beta-E2) in endometrial carcinoma cells.	17beta-e2	235-244	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
23544495-2	2013	METHODS: Expressions of GPER protein were detected by immunohistochemical SP method in Ishikawa and HEC-1A cells.	TFF2 protein, human	74-76	G protein-coupled estrogen receptor 1	Homo sapiens	24-28
23544495-4	2013	RESULTS: (1) Immunohistochemical SP method showed that GPER was positive stained in cell cytoplasm of Ishikawa and HEC-1A cell.	TFF2 protein, human	33-35	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
23135268-5	2012	In this study, we demonstrate for the first time that 17beta-estradiol (E2) and the selective GPER ligand G-1 regulate FASN expression and activity through the GPER-mediated signaling, which involved the EGF receptor/ERK/c-Fos/AP1 transduction pathway, as ascertained by using specific pharmacological inhibitors, performing gene-silencing experiments and ChIP assays in breast SkBr3, colorectal LoVo, hepatocarcinoma HepG2 cancer cells, and breast cancer-associated fibroblasts.	Estradiol	54-70	G protein-coupled estrogen receptor 1	Homo sapiens	160-164
23273253-1	2012	BACKGROUND: G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17beta-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells.	Tamoxifen	105-114	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
23273253-1	2012	BACKGROUND: G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17beta-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells.	Tamoxifen	105-114	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
23043685-10	2013	Treatment with 0.1 muM 17beta-estradiol increased mRNA expression of GPR30 in leiomyoma SMCs but decreased expression in myometrial SMCs.	17beta	23-29	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
22453024-0	2013	Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	100-105
22453024-0	2013	Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR30.	Raloxifene Hydrochloride	14-24	G protein-coupled estrogen receptor 1	Homo sapiens	100-105
22453024-7	2013	CONCLUSION: GPR30 is required for the proliferation of hFOB cells induced by estradiol or raloxifene.	Estradiol	77-86	G protein-coupled estrogen receptor 1	Homo sapiens	12-17
22453024-7	2013	CONCLUSION: GPR30 is required for the proliferation of hFOB cells induced by estradiol or raloxifene.	Raloxifene Hydrochloride	90-100	G protein-coupled estrogen receptor 1	Homo sapiens	12-17
23273253-1	2012	BACKGROUND: G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17beta-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells.	Estradiol	82-98	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
23273253-1	2012	BACKGROUND: G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17beta-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells.	Estradiol	82-98	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
22552965-0	2012	Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	78-82
22899172-11	2012	Pretreatment with "classic" (ERalpha and ERbeta) or "non classic" (GPR30) oestrogen receptor (ER) inhibitors (ICI182,780 and PTX, respectively) counteracted the ability of Apigenin to decrease the TNFalpha-triggered activation of the Akt pathway.	ptx	125-128	G protein-coupled estrogen receptor 1	Homo sapiens	67-72
22878119-7	2012	Dydrogesterone and dienogest also significantly suppress ESR1 and ESR2 transcription, whereas medroxyprogestrone acetate and dydrogesterone significantly reduce mRNA levels of GPER.	medroxyprogestrone acetate	94-120	G protein-coupled estrogen receptor 1	Homo sapiens	176-180
22878119-7	2012	Dydrogesterone and dienogest also significantly suppress ESR1 and ESR2 transcription, whereas medroxyprogestrone acetate and dydrogesterone significantly reduce mRNA levels of GPER.	Dydrogesterone	125-139	G protein-coupled estrogen receptor 1	Homo sapiens	176-180
22552965-2	2012	BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ERalpha and ERbeta) and through the G protein-coupled receptor (GPR30/GPER).	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	158-162
22552965-3	2012	In this regard, recent studies have shown that GPER was involved in the proliferative effects induced by BPA in both normal and tumor cells.	bisphenol A	105-108	G protein-coupled estrogen receptor 1	Homo sapiens	47-51
22552965-2	2012	BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ERalpha and ERbeta) and through the G protein-coupled receptor (GPR30/GPER).	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	152-157
22552965-6	2012	Specific pharmacological inhibitors and gene-silencing procedures were used to show that BPA induces the expression of the GPER target genes c-FOS, EGR-1, and CTGF through the GPER/EGFR/ERK transduction pathway in SKBR3 breast cancer cells and CAFs.	bisphenol A	89-92	G protein-coupled estrogen receptor 1	Homo sapiens	123-127
22858342-10	2012	Cytosolic calcium concentration elevates faster and with higher amplitude following G-1 intracellular microinjections compared to extracellular exposure, suggesting subcellular GPER functionality.	Calcium	10-17	G protein-coupled estrogen receptor 1	Homo sapiens	177-181
22552965-6	2012	Specific pharmacological inhibitors and gene-silencing procedures were used to show that BPA induces the expression of the GPER target genes c-FOS, EGR-1, and CTGF through the GPER/EGFR/ERK transduction pathway in SKBR3 breast cancer cells and CAFs.	bisphenol A	89-92	G protein-coupled estrogen receptor 1	Homo sapiens	176-180
22552965-8	2012	CONCLUSIONS: Results indicate that GPER is involved in the biological action elicited by BPA in breast cancer cells and CAFs.	bisphenol A	89-92	G protein-coupled estrogen receptor 1	Homo sapiens	35-39
21971420-4	2012	Finally, estradiol modulates dendritogenesis by the inhibition of Notch signaling, by a mechanism that, at least in hippocampal neurons, is mediated by G-protein coupled receptor 30.	Estradiol	9-18	G protein-coupled estrogen receptor 1	Homo sapiens	152-181
22858342-11	2012	Thus, GPER activation results in spinal nociception, and the downstream mechanisms involve cytosolic calcium increase, ROS accumulation, and neuronal membrane depolarization.	Calcium	101-108	G protein-coupled estrogen receptor 1	Homo sapiens	6-10
22858342-11	2012	Thus, GPER activation results in spinal nociception, and the downstream mechanisms involve cytosolic calcium increase, ROS accumulation, and neuronal membrane depolarization.	Reactive Oxygen Species	119-122	G protein-coupled estrogen receptor 1	Homo sapiens	6-10
22858342-12	2012	PERSPECTIVE: Our results suggest that GPER modulates pain processing in spinal sensory neurons via cytosolic calcium increase and ROS accumulation.	Calcium	109-116	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
22858342-12	2012	PERSPECTIVE: Our results suggest that GPER modulates pain processing in spinal sensory neurons via cytosolic calcium increase and ROS accumulation.	Reactive Oxygen Species	130-133	G protein-coupled estrogen receptor 1	Homo sapiens	38-42
22306576-4	2012	In addition to the insulinotropic action of ERbeta, the newly described estrogen receptor, GPR30, is involved in the insulinotropic effects of high doses of E2 (100nM-5muM).	Estradiol	157-159	G protein-coupled estrogen receptor 1	Homo sapiens	91-96
22270964-7	2012	RESULTS: Downregulation of GPR30 led to reduced growth and invasion by cells treated with 17beta-estradiol.	Estradiol	90-106	G protein-coupled estrogen receptor 1	Homo sapiens	27-32
22525040-5	2012	The combination of Expand High Fidelity(PLUS) and SYTO9 in the presence of 2.0 mM MgCl(2) produced the best separation in melting curves of mutations in all regions of the GPR30 ORF.	Magnesium Chloride	82-89	G protein-coupled estrogen receptor 1	Homo sapiens	172-177
22147081-0	2012	GPER mediates the Egr-1 expression induced by 17beta-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.	Estradiol	46-62	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
22147081-0	2012	GPER mediates the Egr-1 expression induced by 17beta-estradiol and 4-hydroxitamoxifen in breast and endometrial cancer cells.	4-hydroxitamoxifen	67-85	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	Estradiol	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	207-212
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	Estradiol	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	213-217
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	4-hydroxitamoxifen	118-136	G protein-coupled estrogen receptor 1	Homo sapiens	207-212
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	4-hydroxitamoxifen	118-136	G protein-coupled estrogen receptor 1	Homo sapiens	213-217
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	Tamoxifen	138-141	G protein-coupled estrogen receptor 1	Homo sapiens	207-212
22147081-2	2012	In a microarray analysis performed in breast cancer cells, 17beta-estradiol (E2) and the estrogen receptor antagonist 4-hydroxitamoxifen (OHT) up-regulated Egr-1 through the G protein-coupled receptor named GPR30/GPER.	Tamoxifen	138-141	G protein-coupled estrogen receptor 1	Homo sapiens	213-217
22147081-5	2012	In addition, we show that GPER mediates the expression of Egr-1 also in carcinoma-associated fibroblasts (CAFs).	cafs	106-110	G protein-coupled estrogen receptor 1	Homo sapiens	26-30
22147081-7	2012	The results obtained in CAFs provide further evidence regarding the potential role exerted by the GPER-dependent Egr-1 up-regulation in tumor development and progression.	cafs	24-28	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
22521564-7	2012	This article represents a summary of a lecture given at the 7(th) International Meeting on Rapid Responses to Steroid Hormones in September 2011 in Axos, Crete, and reviews the current knowledge and questions about GPER-dependent signaling and function.	Steroids	110-126	G protein-coupled estrogen receptor 1	Homo sapiens	215-219
22495674-3	2012	A broad literature suggests that GPR30 is a Gs-coupled heptahelical transmembrane receptor that promotes specific binding of naturally occurring and man-made estrogens but not cortisol, progesterone, or testosterone.	Hydrocortisone	176-184	G protein-coupled estrogen receptor 1	Homo sapiens	33-38
22495674-3	2012	A broad literature suggests that GPR30 is a Gs-coupled heptahelical transmembrane receptor that promotes specific binding of naturally occurring and man-made estrogens but not cortisol, progesterone, or testosterone.	Progesterone	186-198	G protein-coupled estrogen receptor 1	Homo sapiens	33-38
22576740-5	2012	In MCF-7 cells, the ErbB2 inhibitor, AG825, the MAPK inhibitor, PD98059, and the MEK1/2 inhibitor, U0126, blocked the HRG-beta1-induced GPR30 expression.	tyrphostin AG825	37-42	G protein-coupled estrogen receptor 1	Homo sapiens	136-141
22576740-5	2012	In MCF-7 cells, the ErbB2 inhibitor, AG825, the MAPK inhibitor, PD98059, and the MEK1/2 inhibitor, U0126, blocked the HRG-beta1-induced GPR30 expression.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	64-71	G protein-coupled estrogen receptor 1	Homo sapiens	136-141
22576740-5	2012	In MCF-7 cells, the ErbB2 inhibitor, AG825, the MAPK inhibitor, PD98059, and the MEK1/2 inhibitor, U0126, blocked the HRG-beta1-induced GPR30 expression.	U 0126	99-104	G protein-coupled estrogen receptor 1	Homo sapiens	136-141
22521737-7	2012	Thus, genistein plays a role in the regulation of MAPK activation via GPR30, and GPR30 represents a novel target regulated by steroid hormones in PDL cells.	Genistein	6-15	G protein-coupled estrogen receptor 1	Homo sapiens	70-75
22521737-7	2012	Thus, genistein plays a role in the regulation of MAPK activation via GPR30, and GPR30 represents a novel target regulated by steroid hormones in PDL cells.	Steroids	126-142	G protein-coupled estrogen receptor 1	Homo sapiens	81-86
22425989-0	2012	The G protein-coupled receptor GPR30 mediates the proliferative and invasive effects induced by hydroxytamoxifen in endometrial cancer cells.	hydroxytamoxifen	96-112	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
22138413-4	2012	We establish that estradiol can activate GPER-cAMP/PKA signalling pathway.	Estradiol	18-27	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
22387674-5	2012	17beta-estradiol signaling is mediated via estrogen receptors, including GPER1, but others receptors, such as the IGF-1 receptor, are implicated in the neuroprotective effect.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	73-78
22387674-7	2012	Compounds that stimulate GPER1 such as selective estrogen receptor modulators and phytoestrogens show neuroprotective activity and are alternatives to 17beta-estradiol.	Estradiol	151-167	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
22425775-6	2012	Moreover, GPR30 boosts HRG-beta1-induced migration and invasion of SkBr3 cells after combinative treatment with E2, 4-hydroxy-tamoxifen or the specific GPR30 agonist G-1, which are blocked by the specific GPR30 antagonist G-15 or the transfection with the small interfering RNA for GPR30.	Estradiol	112-114	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
22425775-6	2012	Moreover, GPR30 boosts HRG-beta1-induced migration and invasion of SkBr3 cells after combinative treatment with E2, 4-hydroxy-tamoxifen or the specific GPR30 agonist G-1, which are blocked by the specific GPR30 antagonist G-15 or the transfection with the small interfering RNA for GPR30.	4'-hydroxytamoxifen	116-135	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
22260839-9	2012	Potentiation occurs at nanomolar steroid levels and depends on GPR30 and EGFR transactivation.	Steroids	33-40	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
22342541-8	2012	Data from proliferation assays on the MCF-7, MDA-MB-231 and SKBr3 cell lines suggested that 7beta-OH-EpiA may also act through the membrane GPR30 receptor.	7beta-oh	92-100	G protein-coupled estrogen receptor 1	Homo sapiens	140-145
22781117-0	2012	[Effect of GPER on the activation of PI3K/Akt induced by 17beta-estradiol in endometrial carcinoma cells].	Estradiol	57-73	G protein-coupled estrogen receptor 1	Homo sapiens	11-15
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	Phosphatidylinositols	100-120	G protein-coupled estrogen receptor 1	Homo sapiens	44-64
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	Phosphatidylinositols	100-120	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	Estradiol	171-187	G protein-coupled estrogen receptor 1	Homo sapiens	44-64
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	Estradiol	171-187	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	17beta-e	189-197	G protein-coupled estrogen receptor 1	Homo sapiens	44-64
22781117-1	2012	OBJECTIVE: To investigate the expression of G protein-coupled ER (GPER) and ER in the activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) induced by 17beta-estradiol (17beta-E(2))in endometrial carcinoma cells, Ishikawa and HEC-1A.	17beta-e	189-197	G protein-coupled estrogen receptor 1	Homo sapiens	66-70
22138413-4	2012	We establish that estradiol can activate GPER-cAMP/PKA signalling pathway.	Cyclic AMP	46-50	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
22251451-0	2012	MIBE acts as antagonist ligand of both estrogen receptor alpha and GPER in breast cancer cells.	mibe	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
22027943-2	2012	The aim of this study was to determine the effects of long-term tibolone (TIB) treatment in comparison with conventional hormone therapy on the expression and distribution of estrogen receptor (ER) alpha, ER-beta, G-protein-coupled ER-1 (GPER), progesterone receptor (PR) A, PRB, androgen receptor (AR), and syndecan-1 in the macaque uterus.	tibolone	74-77	G protein-coupled estrogen receptor 1	Homo sapiens	214-236
22027943-2	2012	The aim of this study was to determine the effects of long-term tibolone (TIB) treatment in comparison with conventional hormone therapy on the expression and distribution of estrogen receptor (ER) alpha, ER-beta, G-protein-coupled ER-1 (GPER), progesterone receptor (PR) A, PRB, androgen receptor (AR), and syndecan-1 in the macaque uterus.	tibolone	74-77	G protein-coupled estrogen receptor 1	Homo sapiens	238-242
22027943-0	2012	Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus.	tibolone	21-29	G protein-coupled estrogen receptor 1	Homo sapiens	85-122
22027943-2	2012	The aim of this study was to determine the effects of long-term tibolone (TIB) treatment in comparison with conventional hormone therapy on the expression and distribution of estrogen receptor (ER) alpha, ER-beta, G-protein-coupled ER-1 (GPER), progesterone receptor (PR) A, PRB, androgen receptor (AR), and syndecan-1 in the macaque uterus.	tibolone	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	214-236
22027943-2	2012	The aim of this study was to determine the effects of long-term tibolone (TIB) treatment in comparison with conventional hormone therapy on the expression and distribution of estrogen receptor (ER) alpha, ER-beta, G-protein-coupled ER-1 (GPER), progesterone receptor (PR) A, PRB, androgen receptor (AR), and syndecan-1 in the macaque uterus.	tibolone	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	238-242
22330739-6	2012	However, activation of GPER protects beta cells from apoptosis, raises glucose-stimulated insulin secretion and lipid homeostasis without affecting insulin biosynthesis.	Glucose	71-78	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
22251451-6	2012	We synthesized a novel compound (ethyl 3-[5-(2-ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]but-2-enoate), referred to as MIBE, and investigated its properties elicited through ERalpha and GPER in breast cancer cells.	ethyl 3-[5-(2-ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1h-indol-3-yl]but-2-enoate	33-115	G protein-coupled estrogen receptor 1	Homo sapiens	200-204
23077529-4	2012	We have designed and synthesized a series of organometallic tricarbonyl-rhenium complexes conjugated to a GPER-selective small molecule derived from tetrahydro-3H-cyclopenta[c]quinoline.	quinoline	176-185	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
23285198-9	2012	N-3 PUFA treatment initiated the pro-apoptotic signaling of estrogen by increasing GPER1-cAMP-PKA signaling response, and blunting EGFR, Erk 1/2, and AKT activity.	Cyclic AMP	89-93	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
23077529-0	2012	Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.	tricarbonyl-re	34-48	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
21312194-0	2012	Bisphenol A promotes testicular seminoma cell proliferation through GPER/GPR30.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	68-72
21312194-0	2012	Bisphenol A promotes testicular seminoma cell proliferation through GPER/GPR30.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	73-78
21802511-0	2011	Diacylglycerol kinase alpha mediates 17-beta-estradiol-induced proliferation, motility, and anchorage-independent growth of Hec-1A endometrial cancer cell line through the G protein-coupled estrogen receptor GPR30.	Estradiol	37-54	G protein-coupled estrogen receptor 1	Homo sapiens	208-213
23077529-0	2012	Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.	tricarbonyl-re	34-48	G protein-coupled estrogen receptor 1	Homo sapiens	125-130
23077529-0	2012	Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.	Technetium	49-51	G protein-coupled estrogen receptor 1	Homo sapiens	120-124
23077529-0	2012	Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30.	Technetium	49-51	G protein-coupled estrogen receptor 1	Homo sapiens	125-130
23077529-4	2012	We have designed and synthesized a series of organometallic tricarbonyl-rhenium complexes conjugated to a GPER-selective small molecule derived from tetrahydro-3H-cyclopenta[c]quinoline.	tricarbonyl-rhenium	60-79	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
23077529-4	2012	We have designed and synthesized a series of organometallic tricarbonyl-rhenium complexes conjugated to a GPER-selective small molecule derived from tetrahydro-3H-cyclopenta[c]quinoline.	tetrahydro-3h-cyclopenta	149-173	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
22295107-5	2012	The treatment with estradiol (E2), anti-estrogenic agents 4-hydroxytamoxifen and ICI 182780, ERbeta specific ligand DPN and GPR30 agonist G1 led to a rapid activation of p-ERK1/2, suggesting the involvement of ERalpha36, ERbeta and GPR30 in the non-genomic signaling pathway in these cells.	Estradiol	19-28	G protein-coupled estrogen receptor 1	Homo sapiens	232-237
22295107-5	2012	The treatment with estradiol (E2), anti-estrogenic agents 4-hydroxytamoxifen and ICI 182780, ERbeta specific ligand DPN and GPR30 agonist G1 led to a rapid activation of p-ERK1/2, suggesting the involvement of ERalpha36, ERbeta and GPR30 in the non-genomic signaling pathway in these cells.	hydroxytamoxifen	58-76	G protein-coupled estrogen receptor 1	Homo sapiens	232-237
22295107-5	2012	The treatment with estradiol (E2), anti-estrogenic agents 4-hydroxytamoxifen and ICI 182780, ERbeta specific ligand DPN and GPR30 agonist G1 led to a rapid activation of p-ERK1/2, suggesting the involvement of ERalpha36, ERbeta and GPR30 in the non-genomic signaling pathway in these cells.	Fulvestrant	81-91	G protein-coupled estrogen receptor 1	Homo sapiens	232-237
22295107-5	2012	The treatment with estradiol (E2), anti-estrogenic agents 4-hydroxytamoxifen and ICI 182780, ERbeta specific ligand DPN and GPR30 agonist G1 led to a rapid activation of p-ERK1/2, suggesting the involvement of ERalpha36, ERbeta and GPR30 in the non-genomic signaling pathway in these cells.	NAD	116-119	G protein-coupled estrogen receptor 1	Homo sapiens	232-237
21791623-10	2011	In summary, GPER activation relaxes coronary artery smooth muscle by increasing potassium efflux via BK(Ca) channels and requires an intact cellular signaling mechanism.	Potassium	80-89	G protein-coupled estrogen receptor 1	Homo sapiens	12-16
21782022-2	2011	We have previously described both a GPER-selective agonist G-1 and antagonist G15 based on a tetrahydro-3H-cyclopenta[c]quinoline scaffold.	SCHEMBL915978	93-129	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
21942929-4	2011	AREAS COVERED: The article aims to review the available evidence relating to the pharmacokinetics, tolerability and efficacy of extended-release gabapentin (GpER).	Gabapentin	145-155	G protein-coupled estrogen receptor 1	Homo sapiens	157-161
22031799-3	2011	METHODS: Immunohistochemistry was used to detect GPER in paraffin-embedded tissues of primary breast cancers from 423 patients and GPER expression was correlated with clinicopathological factors.	Paraffin	57-65	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
21809103-1	2011	Estradiol and progesterone mediate their actions by binding to classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) and progesterone receptor A and B (PR-A and PR-B) and the non-classical G protein-coupled estrogen receptor (GPER).	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	234-269
21809103-1	2011	Estradiol and progesterone mediate their actions by binding to classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) and progesterone receptor A and B (PR-A and PR-B) and the non-classical G protein-coupled estrogen receptor (GPER).	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	271-275
21844907-5	2011	However, 17beta-estradiol also mediates rapid signaling events via pathways that involve transmembrane ERs, such as G-protein-coupled ER 1 (GPER; formerly known as GPR30).	Estradiol	9-25	G protein-coupled estrogen receptor 1	Homo sapiens	116-138
21844907-5	2011	However, 17beta-estradiol also mediates rapid signaling events via pathways that involve transmembrane ERs, such as G-protein-coupled ER 1 (GPER; formerly known as GPR30).	Estradiol	9-25	G protein-coupled estrogen receptor 1	Homo sapiens	140-144
21844907-5	2011	However, 17beta-estradiol also mediates rapid signaling events via pathways that involve transmembrane ERs, such as G-protein-coupled ER 1 (GPER; formerly known as GPR30).	Estradiol	9-25	G protein-coupled estrogen receptor 1	Homo sapiens	164-169
22319655-5	2011	Moreover, it is noteworthy that GPR 30 (a transmembrane ER) induces rapid responses after estradiol binding, which, in turn, modulates cyclins and proapoptotic factors (e.g., BAX) to affect germ cell cycle progression and apoptosis.	Estradiol	90-99	G protein-coupled estrogen receptor 1	Homo sapiens	32-38
21607586-1	2011	Recently, we have shown that the new G-protein-coupled estrogen receptor GPR30 plays an important role in the development of tamoxifen resistance in vitro.	Tamoxifen	125-134	G protein-coupled estrogen receptor 1	Homo sapiens	73-78
21607586-2	2011	This study was undertaken to evaluate the correlation between GPR30 and tamoxifen resistance in breast cancer patients.	Tamoxifen	72-81	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
21607586-4	2011	The association between GPR30 expression and tamoxifen resistance was confirmed in a second cohort of 103 patients treated only with tamoxifen.	Tamoxifen	45-54	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
21607586-4	2011	The association between GPR30 expression and tamoxifen resistance was confirmed in a second cohort of 103 patients treated only with tamoxifen.	Tamoxifen	133-142	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
21607586-7	2011	In a first cohort, survival analysis showed that GPR30 was negatively correlated with relapse-free survival (RFS) only in patients treated with tamoxifen (tamoxifen with or without chemotherapy).	Tamoxifen	144-153	G protein-coupled estrogen receptor 1	Homo sapiens	49-54
21607586-7	2011	In a first cohort, survival analysis showed that GPR30 was negatively correlated with relapse-free survival (RFS) only in patients treated with tamoxifen (tamoxifen with or without chemotherapy).	Tamoxifen	155-164	G protein-coupled estrogen receptor 1	Homo sapiens	49-54
21607586-9	2011	In a subset of patients treated only with tamoxifen, multivariate analysis revealed that GPR30 expression is an independent unfavorable factor for RFS (HR = 4.440; 95% CI, 1.408-13.997; P = 0.011).	Tamoxifen	42-51	G protein-coupled estrogen receptor 1	Homo sapiens	89-94
21607586-11	2011	In 33 paired biopsies obtained before and after adjuvant therapy, GPR30 expression significantly increased only under tamoxifen treatment (P = 0.001).	Tamoxifen	118-127	G protein-coupled estrogen receptor 1	Homo sapiens	66-71
21607586-12	2011	GPR30 expression in breast cancer independently predicts a poor RFS in patients treated with tamoxifen.	Tamoxifen	93-102	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
21300668-5	2011	Treatment of cells with pertussis toxin or inhibition of GPR30/epidermal growth factor receptor kinase transactivation prevented equol-induced activation of extracellular signal-regulated kinase 1/2 via c-Src, Akt, and eNOS.	Equol	129-134	G protein-coupled estrogen receptor 1	Homo sapiens	57-62
21354433-2	2011	GPER promotes estrogen binding and rapid signaling via membrane-associated enzymes resulting in increased cAMP and release of heparan bound epidermal growth factor (proHB-EGF) from breast cancer cells.	Cyclic AMP	106-110	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
21354433-2	2011	GPER promotes estrogen binding and rapid signaling via membrane-associated enzymes resulting in increased cAMP and release of heparan bound epidermal growth factor (proHB-EGF) from breast cancer cells.	heparan	126-133	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
21354433-5	2011	Upon ectopic expression in human embryonic kidney HEK-293 cells, functional GPER is generated as these cells acquire the capacity to stimulate cAMP and activate cyclic AMP responsive binding protein in response to estradiol-17 beta stimulation.	Cyclic AMP	143-147	G protein-coupled estrogen receptor 1	Homo sapiens	76-80
21354433-5	2011	Upon ectopic expression in human embryonic kidney HEK-293 cells, functional GPER is generated as these cells acquire the capacity to stimulate cAMP and activate cyclic AMP responsive binding protein in response to estradiol-17 beta stimulation.	Cyclic AMP	161-171	G protein-coupled estrogen receptor 1	Homo sapiens	76-80
21354433-5	2011	Upon ectopic expression in human embryonic kidney HEK-293 cells, functional GPER is generated as these cells acquire the capacity to stimulate cAMP and activate cyclic AMP responsive binding protein in response to estradiol-17 beta stimulation.	Estradiol	214-223	G protein-coupled estrogen receptor 1	Homo sapiens	76-80
21354433-5	2011	Upon ectopic expression in human embryonic kidney HEK-293 cells, functional GPER is generated as these cells acquire the capacity to stimulate cAMP and activate cyclic AMP responsive binding protein in response to estradiol-17 beta stimulation.	17 beta	224-231	G protein-coupled estrogen receptor 1	Homo sapiens	76-80
21545416-5	2011	GPR30, now designated as GPER-1 (http://www.iuphar-db.org/DATABASE/FamilyIntroductionForward?familyId=22), a newly characterized "orphan receptor", has been implicated in mediating the rapid effects of estradiol and most recently those of aldosterone.	Estradiol	202-211	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
21545416-5	2011	GPR30, now designated as GPER-1 (http://www.iuphar-db.org/DATABASE/FamilyIntroductionForward?familyId=22), a newly characterized "orphan receptor", has been implicated in mediating the rapid effects of estradiol and most recently those of aldosterone.	Estradiol	202-211	G protein-coupled estrogen receptor 1	Homo sapiens	25-31
21545416-5	2011	GPR30, now designated as GPER-1 (http://www.iuphar-db.org/DATABASE/FamilyIntroductionForward?familyId=22), a newly characterized "orphan receptor", has been implicated in mediating the rapid effects of estradiol and most recently those of aldosterone.	Aldosterone	239-250	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
21545416-5	2011	GPR30, now designated as GPER-1 (http://www.iuphar-db.org/DATABASE/FamilyIntroductionForward?familyId=22), a newly characterized "orphan receptor", has been implicated in mediating the rapid effects of estradiol and most recently those of aldosterone.	Aldosterone	239-250	G protein-coupled estrogen receptor 1	Homo sapiens	25-31
21540189-7	2011	GPER is ubiquitinated at the cell surface, exhibits a short half-life (t1/2;) &lt;1 h), and is protected from degradation by the proteasome inhibitor, MG132.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	151-156	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
21540189-8	2011	Disruption of the TGN by brefeldin A induces the accumulation of endocytosed GPER in Rab11+ perinuclear endosomes and prevents GPER degradation.	Brefeldin A	25-36	G protein-coupled estrogen receptor 1	Homo sapiens	77-81
21540189-8	2011	Disruption of the TGN by brefeldin A induces the accumulation of endocytosed GPER in Rab11+ perinuclear endosomes and prevents GPER degradation.	Brefeldin A	25-36	G protein-coupled estrogen receptor 1	Homo sapiens	127-131
21493710-5	2011	Genistein can also activate signaling through GPR30, a G-protein-coupled cell surface receptor.	Genistein	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	46-51
21493710-7	2011	We show herein that nanomolar concentrations of genistein induce ASAH1 transcription through a GPR30-dependent, pertussis toxin-sensitive pathway that requires the activation of c-Src and extracellular signal regulated kinase 1/2 (ERK1/2).	Genistein	48-57	G protein-coupled estrogen receptor 1	Homo sapiens	95-100
21660819-11	2011	Atrazine does not appear to interact strongly with estrogen receptors alpha or beta but may interact with putative estrogen receptor GPR30 (G-protein-coupled receptor).	Atrazine	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	133-138
21278053-8	2011	Instead, Akt and ERK1/2 phosphorylation induced by dieldrin in CGC was mediated by multiple activation of ERalpha, ERbeta, and G protein-coupled receptor 30.	Dieldrin	51-59	G protein-coupled estrogen receptor 1	Homo sapiens	127-156
21138734-8	2011	We hypothesize that GPR30 plays an important role in mediating direct effects of estradiol on basal forebrain cholinergic neurons, with corresponding effects on cognitive performance.	Estradiol	81-90	G protein-coupled estrogen receptor 1	Homo sapiens	20-25
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	G protein-coupled estrogen receptor 1	Homo sapiens	148-152
21266576-7	2011	Taken together, our data suggest that the hypoxia-induced expression of GPER may be included among the mechanisms involved in the anti-apoptotic effects elicited by estrogens, particularly in a low oxygen microenvironment.	Oxygen	198-204	G protein-coupled estrogen receptor 1	Homo sapiens	72-76
20875696-0	2011	Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	57-62
21149639-9	2011	We conclude that GPER1-mediated stimulation of cAMP production and beta-arrestin2 recruitment occur in the PM.	Cyclic AMP	47-51	G protein-coupled estrogen receptor 1	Homo sapiens	17-22
21278491-1	2011	GPR30 is a 7-transmembrane G protein-coupled estrogen receptor that functions alongside traditional estrogen receptors to regulate cellular responses to 17beta-estradiol and environmental estrogens.	Estradiol	153-169	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
21242460-0	2011	GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone.	Aldosterone	102-113	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
21242460-5	2011	The present studies were undertaken to test the hypothesis that the rapid response to aldosterone in smooth muscle is dependent on the availability of a GPR30-dependent signaling pathway.	Aldosterone	86-97	G protein-coupled estrogen receptor 1	Homo sapiens	153-158
20875696-7	2011	As a conclusion, GPR30 plays an important role in the BPA-induced activation of Erk1/2 in a manner distinguishable from that in ERalpha-mediated signaling.	bisphenol A	54-57	G protein-coupled estrogen receptor 1	Homo sapiens	17-22
20568229-11	2010	We also observed that, CCL18 interferes with the activation of GPR30 by previously identified ligands (17beta-estradiol and chemical agonists).	Estradiol	103-119	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
24999376-4	2011	Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated.	Nitric Oxide	169-181	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
24999376-4	2011	Using knock-out animals or drugs selectively targeting GPER/GPR30, a significant role for this receptor as a mediator of acute estrogen-dependent vasodilation involving nitric oxide (NO) and blood pressure-lowering activity has been demonstrated.	Nitric Oxide	169-181	G protein-coupled estrogen receptor 1	Homo sapiens	60-65
20508064-11	2010	The cyclic variations of GPER mRNA obviously relate to strong epithelial expression in the proliferative phase, and the expression pattern suggests regulation by ovarian steroids.	Steroids	170-178	G protein-coupled estrogen receptor 1	Homo sapiens	25-29
19931550-1	2010	Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor.	Estradiol	129-145	G protein-coupled estrogen receptor 1	Homo sapiens	58-87
19911269-0	2010	Role of GPR30 in the mechanisms of tamoxifen resistance in breast cancer MCF-7 cells.	Tamoxifen	35-44	G protein-coupled estrogen receptor 1	Homo sapiens	8-13
19911269-4	2010	These tamoxifen-resistant cells (TAM-R) exhibited enhanced sensitivity to 17-ss-estradiol and GPR30 agonist, G1, when compared to the parental cells.	Tamoxifen	6-15	G protein-coupled estrogen receptor 1	Homo sapiens	94-99
19911269-4	2010	These tamoxifen-resistant cells (TAM-R) exhibited enhanced sensitivity to 17-ss-estradiol and GPR30 agonist, G1, when compared to the parental cells.	tam-r	33-38	G protein-coupled estrogen receptor 1	Homo sapiens	94-99
19911269-6	2010	These effects were abolished by EGFR inhibitor AG1478, GPR30 anti-sense oligonucleotide, and the selective c-Src inhibitor PP2.	Oligonucleotides	72-87	G protein-coupled estrogen receptor 1	Homo sapiens	55-60
19911269-9	2010	Continuous treatment of MCF-7 cells with GPR30 agonist G1 mimics the long-term treatment with tamoxifen and increases drastically its agonistic activity.	Tamoxifen	94-103	G protein-coupled estrogen receptor 1	Homo sapiens	41-46
19911269-10	2010	This data suggests the important role of GPR30/EGFR receptor signaling in the development of tamoxifen resistance.	Tamoxifen	93-102	G protein-coupled estrogen receptor 1	Homo sapiens	41-46
19931550-1	2010	Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor.	Estradiol	129-145	G protein-coupled estrogen receptor 1	Homo sapiens	89-93
19931550-1	2010	Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor.	Estradiol	129-145	G protein-coupled estrogen receptor 1	Homo sapiens	113-118
19931550-7	2010	The comparisons show that croaker and human GPER have very similar estrogen binding characteristics, typical of estrogen membrane receptors, and activate the same estrogen signaling pathways via stimulatory G proteins (Gs) resulting in increased cAMP production.	Cyclic AMP	246-250	G protein-coupled estrogen receptor 1	Homo sapiens	44-48
19472088-5	2010	This effect may be due to up-regulation of G-coupled estrogen receptor, GPR30, which is activated by tamoxifen.	Tamoxifen	101-110	G protein-coupled estrogen receptor 1	Homo sapiens	72-77
20551055-0	2010	Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.	17beta	51-57	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
20551055-0	2010	Nuclear alternate estrogen receptor GPR30 mediates 17beta-estradiol-induced gene expression and migration in breast cancer-associated fibroblasts.	Estradiol	58-67	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
20486699-4	2010	Therefore, we developed a series of GPR30-targeted (111/113)In(III)-labeled analogues using macrocyclic and acyclic polyamino-polycarboxylate chelate designs that would render either a net negative or neutral charge.	polyamino-polycarboxylate	116-141	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
20456608-12	2010	Third, oestradiol causes rapid, direct, excitatory action in GnRH neurones and this action of oestradiol appears to be mediated through a membrane receptor, such as G-protein coupled receptor 30.	Estradiol	7-17	G protein-coupled estrogen receptor 1	Homo sapiens	165-194
20456608-12	2010	Third, oestradiol causes rapid, direct, excitatory action in GnRH neurones and this action of oestradiol appears to be mediated through a membrane receptor, such as G-protein coupled receptor 30.	Estradiol	94-104	G protein-coupled estrogen receptor 1	Homo sapiens	165-194
20138962-0	2010	Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells.	Estriol	0-7	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
20401403-0	2010	Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs.	1,2,3,4-tetrahydroquinoline	95-114	G protein-coupled estrogen receptor 1	Homo sapiens	55-60
20153348-0	2010	The membrane estrogen receptor GPR30 mediates cadmium-induced proliferation of breast cancer cells.	Cadmium	46-53	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
20153348-4	2010	Here, we have investigated whether the newly appreciated transmembrane estrogen receptor, G-protein coupled receptor 30 (GPR30), may be involved in Cd-induced cell proliferation.	Cadmium	148-150	G protein-coupled estrogen receptor 1	Homo sapiens	90-119
20153348-4	2010	Here, we have investigated whether the newly appreciated transmembrane estrogen receptor, G-protein coupled receptor 30 (GPR30), may be involved in Cd-induced cell proliferation.	Cadmium	148-150	G protein-coupled estrogen receptor 1	Homo sapiens	121-126
20153348-10	2010	These results demonstrate that Cd-induced breast cancer cell proliferation occurs through GPR30-mediated activation in a manner that is similar to that achieved by estrogen in these cells.	Cadmium	31-33	G protein-coupled estrogen receptor 1	Homo sapiens	90-95
20401403-1	2010	The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(III)-catalyzed aza-Diels-Alder cyclization.	aza-diels	131-140	G protein-coupled estrogen receptor 1	Homo sapiens	4-9
20211987-11	2010	These findings provide insight into the molecular mechanisms of GPER-1/ERRalpha-mediated signaling and may be relevant to what happens in breast cancer cells escaping inhibitory control by TAM.	Tamoxifen	189-192	G protein-coupled estrogen receptor 1	Homo sapiens	64-70
19741198-0	2009	Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	94-100
20041667-0	2010	Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30.	1,2,3,4-tetrahydroquinoline	44-64	G protein-coupled estrogen receptor 1	Homo sapiens	115-120
20041667-1	2010	A series of iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines was synthesized as potential targeted imaging agents for the G protein-coupled estrogen receptor GPR30.	iodo-substituted tetrahydro-3h-cyclopenta[c]quinolines	12-66	G protein-coupled estrogen receptor 1	Homo sapiens	164-169
20041667-3	2010	Selected iodo-substituted tetrahydro-3H-cyclopenta[c]quinolines exhibited IC(50) values lower than 20 nM in competitive binding studies with GPR30-expressing human endometrial cancer cells.	iodo-substituted tetrahydro-3h-cyclopenta[c]quinolines	9-63	G protein-coupled estrogen receptor 1	Homo sapiens	141-146
20041667-4	2010	These compounds functioned as antagonists of GPR30 and blocked estrogen-induced PI3K activation and calcium mobilization.	Calcium	100-107	G protein-coupled estrogen receptor 1	Homo sapiens	45-50
20086172-6	2010	In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells.	hydroxytamoxifen	109-127	G protein-coupled estrogen receptor 1	Homo sapiens	139-144
20086172-7	2010	Additionally, in MCF-7 cells, GPR30 depletion blocked E(2)-induced and G-1-induced Ca(2+) mobilization, but ERalpha depletion did not.	Estradiol	54-58	G protein-coupled estrogen receptor 1	Homo sapiens	30-35
20639684-6	2010	Both GPER agonists attenuated contractions to endothelin-1 (p &lt; 0.05 vs. ethanol), but not to serotonin (n.s.).	Ethanol	76-83	G protein-coupled estrogen receptor 1	Homo sapiens	5-9
20197310-5	2010	Both 17beta-estradiol (E2) and G1, a compound reported to be a selective GPR30 agonist, increased the phosphorylation levels of the MAPK/ERK1/2 in SK-BR-3 cells, which could be blocked by an anti-ER-alpha36-specific antibody against its ligand-binding domain.	Estradiol	5-21	G protein-coupled estrogen receptor 1	Homo sapiens	73-78
20086172-1	2010	The G protein-coupled receptor GPR30 binds 17beta-estradiol (E(2)) yet differs from classic estrogen receptors (ERalpha and ERbeta).	Estradiol	43-59	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
20086172-2	2010	GPR30 can mediate E(2)-induced nongenomic signaling, but its role in ERalpha-positive breast cancer remains unclear.	Estradiol	18-22	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
20086172-4	2010	We therefore examined GPR30 in estrogenic activities in ER-positive MCF-7 breast cancer cells using G-1 and diethylstilbestrol (DES), ligands that selectively activate GPR30 and ER, respectively, and small interfering RNAs.	Diethylstilbestrol	108-126	G protein-coupled estrogen receptor 1	Homo sapiens	22-27
20086172-4	2010	We therefore examined GPR30 in estrogenic activities in ER-positive MCF-7 breast cancer cells using G-1 and diethylstilbestrol (DES), ligands that selectively activate GPR30 and ER, respectively, and small interfering RNAs.	Diethylstilbestrol	128-131	G protein-coupled estrogen receptor 1	Homo sapiens	22-27
20086172-4	2010	We therefore examined GPR30 in estrogenic activities in ER-positive MCF-7 breast cancer cells using G-1 and diethylstilbestrol (DES), ligands that selectively activate GPR30 and ER, respectively, and small interfering RNAs.	Diethylstilbestrol	128-131	G protein-coupled estrogen receptor 1	Homo sapiens	168-173
20086172-6	2010	In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells.	Estradiol	65-69	G protein-coupled estrogen receptor 1	Homo sapiens	32-37
20086172-6	2010	In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells.	Estradiol	103-107	G protein-coupled estrogen receptor 1	Homo sapiens	32-37
20086172-6	2010	In Ca(2+) mobilization studies, GPR30, but not ERalpha, mediated E(2)-induced Ca(2+) responses because E(2), 4-hydroxytamoxifen (activates GPR30), and G-1, but not DES, elicited cytosolic Ca(2+) increases not only in MCF-7 cells but also in ER-negative SKBr3 cells.	hydroxytamoxifen	109-127	G protein-coupled estrogen receptor 1	Homo sapiens	32-37
19741198-1	2009	Recent studies suggest that the rapid and nongenomic effects of estradiol may be mediated through the G protein-coupled receptor dubbed GPR30 receptor.	Estradiol	64-73	G protein-coupled estrogen receptor 1	Homo sapiens	136-141
19741198-2	2009	The present study examines the role of GPR30 versus a classical estrogen receptor (ERalpha) in mediating the growth regulatory effects of estradiol.	Estradiol	138-147	G protein-coupled estrogen receptor 1	Homo sapiens	39-44
19741198-6	2009	Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs.	Estradiol	44-53	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
19741198-6	2009	Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs.	Estradiol	123-132	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
19741198-6	2009	Transfer of the genes encoding GPR30 led to estradiol stimulation of ERK phosphorylation, which is opposite the effects of estradiol in the primary culture of VSMCs.	vsmcs	159-164	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
19741198-8	2009	Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA).	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	65-70
19741198-8	2009	Estradiol-mediated stimulation of ERK subsequent to heterologous GPR30 expression was pertussis toxin sensitive and phosphoinositide 3-kinase (PI3 kinase) dependent; under these conditions, estradiol also inhibited protein kinase A (PKA).	Estradiol	190-199	G protein-coupled estrogen receptor 1	Homo sapiens	65-70
19464786-4	2009	Not only does GPR30 mediate some of the rapid signal transduction events following cell stimulation, such as calcium mobilization and kinase activation, it also appears to regulate rapid transcriptional activation of genes such as c-fos.	Calcium	109-116	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
19749156-2	2009	We demonstrate that epidermal growth factor (EGF) and TGF alpha transactivate the GPR30 promoter and accordingly up-regulate GPR30 mRNA and protein levels only in endometrial and tamoxifen-resistant breast cancer cells.	Tamoxifen	179-188	G protein-coupled estrogen receptor 1	Homo sapiens	82-87
19749156-2	2009	We demonstrate that epidermal growth factor (EGF) and TGF alpha transactivate the GPR30 promoter and accordingly up-regulate GPR30 mRNA and protein levels only in endometrial and tamoxifen-resistant breast cancer cells.	Tamoxifen	179-188	G protein-coupled estrogen receptor 1	Homo sapiens	125-130
19749156-6	2009	Given that EGFR/HER2 overexpression is associated with tamoxifen resistance, our data may suggest that ligand-activated EGFR could contribute to the failure of tamoxifen therapy also by up-regulating GPR30, which in turn could facilitates the action of estrogen.	Tamoxifen	55-64	G protein-coupled estrogen receptor 1	Homo sapiens	200-205
19749156-7	2009	In addition, important for resistance is the ability of tamoxifen to bind to and activate GPR30, the expression of which is up-regulated by EGFR activation.	Tamoxifen	56-65	G protein-coupled estrogen receptor 1	Homo sapiens	90-95
19549922-0	2009	Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation.	Tamoxifen	53-62	G protein-coupled estrogen receptor 1	Homo sapiens	16-21
19549922-4	2009	Using a novel tamoxifen analogue, STX, which activates GPR30 but not ERs, significant stimulation of the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways was observed in H-38 cells and in Ishikawa endometrial cancer cells expressing GPR30; a similar effect was observed in JEG3 choriocarcinoma cells.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	55-60
19549922-4	2009	Using a novel tamoxifen analogue, STX, which activates GPR30 but not ERs, significant stimulation of the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways was observed in H-38 cells and in Ishikawa endometrial cancer cells expressing GPR30; a similar effect was observed in JEG3 choriocarcinoma cells.	Tamoxifen	14-23	G protein-coupled estrogen receptor 1	Homo sapiens	274-279
19549922-6	2009	Consistent with these findings, STX, tamoxifen, and the phytoestrogen genistein were able to increase SF-1 transcription, promote Ishikawa cell proliferation, and induce the SF-1 target gene aromatase in a GPR30-dependent manner.	Tamoxifen	37-46	G protein-coupled estrogen receptor 1	Homo sapiens	206-211
19549922-8	2009	We propose that this novel GPR30/SF-1 pathway increases local concentrations of estrogen, and together with classic ER signaling, mediate the proliferative effects of synthetic estrogens such as tamoxifen, in promoting endometriosis and endometrial cancers.	Tamoxifen	195-204	G protein-coupled estrogen receptor 1	Homo sapiens	27-32
19428439-5	2009	The increase of bromodeoxyuridine uptake by diosgenin was blocked by an adenylate cyclase inhibitor, but not by antisense oligonucleotides against estrogen receptor alpha, estrogen receptor beta or an orphan G-protein-coupled receptor, GPR30, indicating the involvement of cAMP but not estrogen receptor alpha, estrogen receptor beta or GPR30.	Bromodeoxyuridine	16-33	G protein-coupled estrogen receptor 1	Homo sapiens	337-342
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Arginine	78-81	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Glycine	82-85	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
19342448-6	2009	Function-blocking antibodies directed against integrin alpha5beta1 or soluble Arg-Gly-Asp peptide fragments derived from FN specifically inhibited GPR30-mediated epidermal growth factor receptor transactivation.	Aspartic Acid	86-89	G protein-coupled estrogen receptor 1	Homo sapiens	147-152
19342448-8	2009	Mutant Shc (317Y/F) blocked GPR30-induced FN matrix assembly and tyrosyl phosphorylation of erbB1.	cyclo(tyrosyl-tyrosyl)	65-72	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
19428439-5	2009	The increase of bromodeoxyuridine uptake by diosgenin was blocked by an adenylate cyclase inhibitor, but not by antisense oligonucleotides against estrogen receptor alpha, estrogen receptor beta or an orphan G-protein-coupled receptor, GPR30, indicating the involvement of cAMP but not estrogen receptor alpha, estrogen receptor beta or GPR30.	Bromodeoxyuridine	16-33	G protein-coupled estrogen receptor 1	Homo sapiens	236-241
19428439-5	2009	The increase of bromodeoxyuridine uptake by diosgenin was blocked by an adenylate cyclase inhibitor, but not by antisense oligonucleotides against estrogen receptor alpha, estrogen receptor beta or an orphan G-protein-coupled receptor, GPR30, indicating the involvement of cAMP but not estrogen receptor alpha, estrogen receptor beta or GPR30.	Diosgenin	44-53	G protein-coupled estrogen receptor 1	Homo sapiens	236-241
19428439-5	2009	The increase of bromodeoxyuridine uptake by diosgenin was blocked by an adenylate cyclase inhibitor, but not by antisense oligonucleotides against estrogen receptor alpha, estrogen receptor beta or an orphan G-protein-coupled receptor, GPR30, indicating the involvement of cAMP but not estrogen receptor alpha, estrogen receptor beta or GPR30.	Diosgenin	44-53	G protein-coupled estrogen receptor 1	Homo sapiens	337-342
19207808-3	2009	The results from a series of studies further suggest that the rapid action of E(2) in primate LHRH neurones appears to be mediated by GPR30.	Estradiol	78-82	G protein-coupled estrogen receptor 1	Homo sapiens	134-139
19162071-8	2009	We also report that the GPR30 is expressed on cultured sensory neurons, that activation of the receptor elicits signaling to increase calcium accumulation.	Calcium	134-141	G protein-coupled estrogen receptor 1	Homo sapiens	24-29
19326083-9	2009	It also increased cellular accumulation of cAMP, a hallmark of GPR30-mediated estrogen signaling.	Cyclic AMP	43-47	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
19326083-10	2009	These data imply that tectoridin exerts its estrogenic effect mainly via the GPR30 and ERK-mediated rapid nongenomic estrogen signaling pathway.	tectoridin	22-32	G protein-coupled estrogen receptor 1	Homo sapiens	77-82
19326083-11	2009	This property of tectoridin sets it aside from genistein where it exerts the estrogenic effects via both an ER-dependent genomic pathway and a GPR30-dependent nongenomic pathway.	tectoridin	17-27	G protein-coupled estrogen receptor 1	Homo sapiens	143-148
19153601-3	2009	We show here for ER-negative human breast cancer cells that the activation of GPR30 signalling by oestrogen or by hydroxytamoxifen (OHT), an ER antagonist but GPR30 agonist, induces a transcription factor network, which resembles that induced by serum in fibroblasts.	hydroxytamoxifen	114-130	G protein-coupled estrogen receptor 1	Homo sapiens	78-83
19153601-3	2009	We show here for ER-negative human breast cancer cells that the activation of GPR30 signalling by oestrogen or by hydroxytamoxifen (OHT), an ER antagonist but GPR30 agonist, induces a transcription factor network, which resembles that induced by serum in fibroblasts.	hydroxytamoxifen	114-130	G protein-coupled estrogen receptor 1	Homo sapiens	159-164
19395996-7	2009	The nuclear ER antagonists ICI 182780 and tamoxifen, which are GPR30 agonists, as well as the specifically constructed GPR30 agonist G1, mimicked the effect of E(2) on uPAR expression and cell migration.	Tamoxifen	42-51	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
19179659-2	2009	Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells.	Calcium	76-83	G protein-coupled estrogen receptor 1	Homo sapiens	15-19
19131510-4	2009	Collectively, E(2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E(2) appears to be mediated, in part, through GPR30.	Estradiol	14-18	G protein-coupled estrogen receptor 1	Homo sapiens	149-154
19131510-4	2009	Collectively, E(2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E(2) appears to be mediated, in part, through GPR30.	Estradiol	103-107	G protein-coupled estrogen receptor 1	Homo sapiens	149-154
19395996-0	2009	Estradiol attenuates EGF-induced rapid uPAR mobilization and cell migration via the G-protein-coupled receptor 30 in ovarian cancer cells.	Estradiol	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	84-113
18566127-4	2008	Recently, an orphan G protein-coupled receptor, GPR30, has been claimed to bind to and to signal in response to estradiol.	Estradiol	112-121	G protein-coupled estrogen receptor 1	Homo sapiens	48-53
19395996-3	2009	G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER).The objective of this study was to explore the effects of 17beta-estradiol (E(2)) on uPAR expression and cell migration in ovarian cancer cells and further to identify the ER involved.We used 7 ovarian cancer cell lines, cell migration assay, cellular binding of (125)I-uPA, cellular degradation of (125)I-uPA/PAI-1 complex, enzyme-linked immunosorbent assay for uPAR, solid-phase enzyme immunoassay for ERalpha, and quantitative polymerase chain reaction.	Estradiol	150-166	G protein-coupled estrogen receptor 1	Homo sapiens	0-29
19395996-3	2009	G-protein-coupled receptor 30 (GPR30) is a newly identified membrane estrogen receptor (ER).The objective of this study was to explore the effects of 17beta-estradiol (E(2)) on uPAR expression and cell migration in ovarian cancer cells and further to identify the ER involved.We used 7 ovarian cancer cell lines, cell migration assay, cellular binding of (125)I-uPA, cellular degradation of (125)I-uPA/PAI-1 complex, enzyme-linked immunosorbent assay for uPAR, solid-phase enzyme immunoassay for ERalpha, and quantitative polymerase chain reaction.	Estradiol	150-166	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
19395996-7	2009	The nuclear ER antagonists ICI 182780 and tamoxifen, which are GPR30 agonists, as well as the specifically constructed GPR30 agonist G1, mimicked the effect of E(2) on uPAR expression and cell migration.	Fulvestrant	27-37	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
19079715-0	2008	G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.	Atrazine	111-119	G protein-coupled estrogen receptor 1	Homo sapiens	0-29
19079715-2	2008	Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions of 17beta-estradiol and environmental estrogens.	Estradiol	164-180	G protein-coupled estrogen receptor 1	Homo sapiens	56-85
19079715-2	2008	Recent investigations have demonstrated that the orphan G-protein-coupled receptor 30 (GPR30), which is structurally unrelated to the ER, mediates rapid actions of 17beta-estradiol and environmental estrogens.	Estradiol	164-180	G protein-coupled estrogen receptor 1	Homo sapiens	87-92
19079715-3	2008	OBJECTIVES: Given the ability of atrazine to exert estrogen-like activity in cancer cells, we evaluated the potential of atrazine to signal through GPR30 in stimulating biological responses in cancer cells.	Atrazine	121-129	G protein-coupled estrogen receptor 1	Homo sapiens	148-153
19079715-7	2008	Using specific signaling inhibitors and gene silencing, we demonstrated that atrazine stimulated the proliferation of ovarian cancer cells through the GPR30-epidermal growth factor receptor transduction pathway and the involvement of ERalpha.	Atrazine	77-85	G protein-coupled estrogen receptor 1	Homo sapiens	151-156
19079715-9	2008	On the basis of the present data, atrazine should be included among the environmental contaminants potentially able to signal via GPR30 in eliciting estrogenic action.	Atrazine	34-42	G protein-coupled estrogen receptor 1	Homo sapiens	130-135
18625716-9	2008	We further examined the function of two genes linked to cAMP signaling as follows: Gpr30 that is stimulated and Rgs2 that is down-regulated by Runx2.	Cyclic AMP	56-60	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
18625716-11	2008	Notwithstanding its growth-suppressive potential, our results surprisingly indicate that Runx2 may sensitize cAMP-related G protein-coupled receptor signaling by activating Gpr30 and repressing Rgs2 gene expression in osteoblasts to increase responsiveness to mitogenic signals.	Cyclic AMP	109-113	G protein-coupled estrogen receptor 1	Homo sapiens	173-178
18768737-0	2008	17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30.	Estradiol	0-17	G protein-coupled estrogen receptor 1	Homo sapiens	173-202
18768737-6	2008	Silencing of GPR30 in MCF-7 cells completely reduced the ability of 17-beta-estradiol (E2) to inhibit the TGF-beta pathway.	Estradiol	68-85	G protein-coupled estrogen receptor 1	Homo sapiens	13-18
18467441-3	2008	Using as a model system SkBr3 and BT20 breast cancer cells lacking the classical ER, the regulation of GPR30 expression by 17beta-estradiol, the selective GPR30 ligand G-1, IGF-I, and epidermal growth factor (EGF) was evaluated.	Estradiol	123-139	G protein-coupled estrogen receptor 1	Homo sapiens	103-108
18467434-5	2008	Transient overexpression of GPR30 inhibited 17beta-estradiol (E2)-induced cell proliferation.	Estradiol	44-60	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
18467434-5	2008	Transient overexpression of GPR30 inhibited 17beta-estradiol (E2)-induced cell proliferation.	Estradiol	62-64	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
17878253-7	2007	Paraffin-embedded sections of the growth plates were used to detect expression of the GPR30 protein.	Paraffin	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	86-91
18275979-4	2008	Specifically, treatment of MCF-7 cells, that express ER alpha, ER beta and GPR30, to 0.5-10 microM Cd for only 2.5 min resulted in transient phosphorylation of ERK1/2.	Cadmium	99-101	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
18275979-6	2008	In SK-BR-3 cells, that express only GPR30, Cd also caused a transient activation of ERK1/2, but not of AKT.	Cadmium	43-45	G protein-coupled estrogen receptor 1	Homo sapiens	36-41
18275979-10	2008	It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and AKT and that these signaling events are mediated by possible interaction with membrane ER alpha and GPR30, but not ER beta.	Cadmium	21-23	G protein-coupled estrogen receptor 1	Homo sapiens	182-187
18420744-1	2008	Human G protein-coupled receptor 30 (GPR30) mediates estradiol-17beta (E2) activation of adenylyl cyclase in breast cancer cells and displays E2 binding typical of membrane estrogen receptors (mERs).	17beta	63-69	G protein-coupled estrogen receptor 1	Homo sapiens	37-42
18420744-6	2008	Consistent with previous findings with human GPR30, estrogen treatment of plasma membranes from both croaker ovaries and GPR30-transfected cells caused activation of a stimulatory G protein (Gs) resulting in increased cAMP production.	Cyclic AMP	218-222	G protein-coupled estrogen receptor 1	Homo sapiens	121-126
18434348-5	2008	GPR30 protein expression was studied by immunohistochemistry in paraffin-embedded sections.	Paraffin	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
18406603-3	2008	Although estrogen"s transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein-coupled receptor, GPR30, which responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production.	Tamoxifen	230-239	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
18406603-3	2008	Although estrogen"s transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein-coupled receptor, GPR30, which responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production.	Calcium	325-332	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
18406603-3	2008	Although estrogen"s transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein-coupled receptor, GPR30, which responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production.	Cyclic AMP	350-354	G protein-coupled estrogen receptor 1	Homo sapiens	192-197
17379646-6	2007	Stimulation of GPR30-expressing HEK-293 cells with 17beta-E2 caused sequestration of GPR30 from the cell surface and resulted in its codistribution with clathrin and mobilization of intracellular calcium stores.	Calcium	196-203	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
17379646-6	2007	Stimulation of GPR30-expressing HEK-293 cells with 17beta-E2 caused sequestration of GPR30 from the cell surface and resulted in its codistribution with clathrin and mobilization of intracellular calcium stores.	Calcium	196-203	G protein-coupled estrogen receptor 1	Homo sapiens	85-90
17379646-7	2007	Evidence that GPR30 signals from the cell surface was obtained from experiments demonstrating that the cell-impermeable E2-protein conjugates E2-BSA and E2-horseradish peroxidase promote GPR30-dependent elevation of intracellular cAMP concentrations.	Cyclic AMP	230-234	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
17379646-7	2007	Evidence that GPR30 signals from the cell surface was obtained from experiments demonstrating that the cell-impermeable E2-protein conjugates E2-BSA and E2-horseradish peroxidase promote GPR30-dependent elevation of intracellular cAMP concentrations.	Cyclic AMP	230-234	G protein-coupled estrogen receptor 1	Homo sapiens	187-192
17379646-8	2007	Subcellular fractionation studies further support the plasma membrane as a site of GPR30 action with specific [3H]17beta-E2 binding and G protein activation associated with plasma membrane but not microsomal, or other fractions, prepared from HEK-293 or SKBR3 breast cancer cells.	Tritium	111-113	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
17379646-8	2007	Subcellular fractionation studies further support the plasma membrane as a site of GPR30 action with specific [3H]17beta-E2 binding and G protein activation associated with plasma membrane but not microsomal, or other fractions, prepared from HEK-293 or SKBR3 breast cancer cells.	17beta-e2	114-123	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
17403429-4	2007	RESULTS: GPR30 correlated positively with epidermal growth factor receptor (P = .005), but negatively with progesterone (P = .05) receptor expression.	Progesterone	107-119	G protein-coupled estrogen receptor 1	Homo sapiens	9-14
17452498-0	2007	Differential effects of 17beta-estradiol on function and expression of estrogen receptor alpha, estrogen receptor beta, and GPR30 in arteries and veins of patients with atherosclerosis.	Estradiol	24-40	G protein-coupled estrogen receptor 1	Homo sapiens	124-129
17452498-10	2007	In summary, this is the first study to report that, in human arteries but not in veins, 17beta-estradiol acutely affects vascular tone, estrogen receptor expression, including GPR30, and extracellular signal-regulated kinase phosphorylation.	Estradiol	88-104	G protein-coupled estrogen receptor 1	Homo sapiens	176-181
16835357-0	2006	17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	140-145
17308128-0	2007	G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.	Estradiol	94-110	G protein-coupled estrogen receptor 1	Homo sapiens	0-29
17308128-0	2007	G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells.	Estradiol	94-110	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
17308128-2	2007	The orphan G protein-coupled receptor 30 (GPR30) mediates the nongenomic signaling of 17beta-estradiol (E2) in a variety of estrogen-sensitive cancer cells through activation of the epidermal growth factor receptor (EGFR) pathway.	Estradiol	86-102	G protein-coupled estrogen receptor 1	Homo sapiens	11-40
17308128-2	2007	The orphan G protein-coupled receptor 30 (GPR30) mediates the nongenomic signaling of 17beta-estradiol (E2) in a variety of estrogen-sensitive cancer cells through activation of the epidermal growth factor receptor (EGFR) pathway.	Estradiol	86-102	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
17088055-4	2006	Bisphenol A, zearalonone, and nonylphenol also had relatively high binding affinities for GPR30 with RBAs of 2-3%.	bisphenol A	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	90-95
17203231-6	2007	GPR30 mRNA expression was significantly reduced in a serum/phenol-free medium.	Phenol	59-65	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
17203231-11	2007	Our results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process.	Steroids	91-99	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
17203231-11	2007	Our results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process.	Estradiol	150-166	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
17088055-4	2006	Bisphenol A, zearalonone, and nonylphenol also had relatively high binding affinities for GPR30 with RBAs of 2-3%.	zearalonone	13-24	G protein-coupled estrogen receptor 1	Homo sapiens	90-95
17088055-4	2006	Bisphenol A, zearalonone, and nonylphenol also had relatively high binding affinities for GPR30 with RBAs of 2-3%.	nonylphenol	30-41	G protein-coupled estrogen receptor 1	Homo sapiens	90-95
17088055-7	2006	Environmental estrogens with relatively high binding affinities for GPR30 (genestein, bisphenol A, nonylphenol and Kepone) also displayed estrogen agonist activities in an in vitro assay of membrane-bound adenylyl cyclase activity, a GPR30-dependent signaling pathway activated by estrogens.	bisphenol A	86-97	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
17088055-7	2006	Environmental estrogens with relatively high binding affinities for GPR30 (genestein, bisphenol A, nonylphenol and Kepone) also displayed estrogen agonist activities in an in vitro assay of membrane-bound adenylyl cyclase activity, a GPR30-dependent signaling pathway activated by estrogens.	nonylphenol	99-110	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
17088055-7	2006	Environmental estrogens with relatively high binding affinities for GPR30 (genestein, bisphenol A, nonylphenol and Kepone) also displayed estrogen agonist activities in an in vitro assay of membrane-bound adenylyl cyclase activity, a GPR30-dependent signaling pathway activated by estrogens.	Chlordecone	115-121	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
17088055-7	2006	Environmental estrogens with relatively high binding affinities for GPR30 (genestein, bisphenol A, nonylphenol and Kepone) also displayed estrogen agonist activities in an in vitro assay of membrane-bound adenylyl cyclase activity, a GPR30-dependent signaling pathway activated by estrogens.	Chlordecone	115-121	G protein-coupled estrogen receptor 1	Homo sapiens	234-239
17090028-0	2006	Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.	tridentate pyridin-2-yl hydrazine tricarbonyl-re/(99m)tc	101-157	G protein-coupled estrogen receptor 1	Homo sapiens	54-59
17090028-1	2006	We describe a new structural class of neutral tridentate pyridin-2-yl hydrazine chelates for labeling with tricarbonyl Re/99mTc(I) under aqueous conditions and investigate the receptor binding of synthetic estradiol derivatives with the novel G-protein-coupled receptor GPR30 and estrogen receptors ERalpha/beta.	2-hydrazinopyridine	57-79	G protein-coupled estrogen receptor 1	Homo sapiens	270-275
17085646-1	2006	PURPOSE: The seven transmembrane receptor, GPR30, is linked to estrogen binding and heparan-bound epidermal growth factor release.	heparan	84-91	G protein-coupled estrogen receptor 1	Homo sapiens	43-48
16835357-0	2006	17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.	Genistein	18-27	G protein-coupled estrogen receptor 1	Homo sapiens	140-145
16835357-0	2006	17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.	hydroxytamoxifen	33-51	G protein-coupled estrogen receptor 1	Homo sapiens	140-145
16835357-5	2006	It is noteworthy that we have demonstrated that the G protein-coupled receptor 30 (GPR30) and the mitogen-activated protein kinase (MAPK) pathway mediate both the up-regulation of c-fos and the growth response to E2, G, and OHT in TC cells studied, because these stimulatory effects were prevented by silencing GPR30 and using the MEK inhibitor 2"-amino-3"-methoxyflavone (PD 98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	345-371	G protein-coupled estrogen receptor 1	Homo sapiens	52-81
16835357-5	2006	It is noteworthy that we have demonstrated that the G protein-coupled receptor 30 (GPR30) and the mitogen-activated protein kinase (MAPK) pathway mediate both the up-regulation of c-fos and the growth response to E2, G, and OHT in TC cells studied, because these stimulatory effects were prevented by silencing GPR30 and using the MEK inhibitor 2"-amino-3"-methoxyflavone (PD 98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	345-371	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
16835357-5	2006	It is noteworthy that we have demonstrated that the G protein-coupled receptor 30 (GPR30) and the mitogen-activated protein kinase (MAPK) pathway mediate both the up-regulation of c-fos and the growth response to E2, G, and OHT in TC cells studied, because these stimulatory effects were prevented by silencing GPR30 and using the MEK inhibitor 2"-amino-3"-methoxyflavone (PD 98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	373-381	G protein-coupled estrogen receptor 1	Homo sapiens	52-81
16835357-5	2006	It is noteworthy that we have demonstrated that the G protein-coupled receptor 30 (GPR30) and the mitogen-activated protein kinase (MAPK) pathway mediate both the up-regulation of c-fos and the growth response to E2, G, and OHT in TC cells studied, because these stimulatory effects were prevented by silencing GPR30 and using the MEK inhibitor 2"-amino-3"-methoxyflavone (PD 98059).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	373-381	G protein-coupled estrogen receptor 1	Homo sapiens	83-88
16239258-0	2006	The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.	Estradiol	83-99	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
16780796-4	2006	Treatment with estrogen (17beta-estradiol or E2) causes an elevation in the intracellular Ca2+ concentration ([Ca2+]i) within 10 s in HeLa cells expressing FLAG-GPR30.	Estradiol	25-41	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
16780796-4	2006	Treatment with estrogen (17beta-estradiol or E2) causes an elevation in the intracellular Ca2+ concentration ([Ca2+]i) within 10 s in HeLa cells expressing FLAG-GPR30.	Estradiol	45-47	G protein-coupled estrogen receptor 1	Homo sapiens	161-166
16239258-0	2006	The G protein-coupled receptor GPR30 mediates the proliferative effects induced by 17beta-estradiol and hydroxytamoxifen in endometrial cancer cells.	hydroxytamoxifen	104-120	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
15705806-4	2005	Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus.	Calcium	55-62	G protein-coupled estrogen receptor 1	Homo sapiens	11-16
16125968-5	2005	Identification of GPR30 as a Gs-coupled 7TM receptor that triggers release of heparin-binding EGF establishes its role in cell signaling cascades initiated by estrogens, and explains their capacity to activate second messengers and promote EGF-like effects.	Heparin	78-85	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
15705806-4	2005	Activating GPR30 by estrogen resulted in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus.	phosphatidylinositol 3,4,5-triphosphate	93-133	G protein-coupled estrogen receptor 1	Homo sapiens	11-16
11773440-5	2002	We show that 17beta-E2 represses EGF-induced activation of the Raf-to-Erk pathway in human breast carcinoma cells that express GPR30, including MCF-7 and SKBR3 cells which express both or neither, ER, respectively.	17beta-e2	13-22	G protein-coupled estrogen receptor 1	Homo sapiens	127-132
15539556-4	2005	Progesterone-induced increases and small interfering RNA-induced decreases in GPR30 expression in SKBR3 cells were accompanied by parallel changes in specific estradiol-17beta (E2) binding.	Estradiol	159-175	G protein-coupled estrogen receptor 1	Homo sapiens	78-83
15511221-1	2004	G protein-coupled receptor 30 (GPR30) has previously been described to be important in steroid-mediated growth and to inhibit cell proliferation.	Steroids	87-94	G protein-coupled estrogen receptor 1	Homo sapiens	0-29
15511221-1	2004	G protein-coupled receptor 30 (GPR30) has previously been described to be important in steroid-mediated growth and to inhibit cell proliferation.	Steroids	87-94	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
15511221-8	2004	In COS cells, transient transfection of GPR30 with glucocorticoid receptor alpha resulted in an abrogation of the MMTV-luc and GRE-luc reporter activities induced by dexamethasone.	Dexamethasone	166-179	G protein-coupled estrogen receptor 1	Homo sapiens	40-45
15245432-9	2004	Antisense oligonucleotide against G-protein-coupled receptor GPR30 suppressed the E2-induced increases of phosphorylated CREB, cyclin D2 level, proliferation, and bromodeoxyuridine incorporation in keratinocytes.	Oligonucleotides	10-25	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
15245432-9	2004	Antisense oligonucleotide against G-protein-coupled receptor GPR30 suppressed the E2-induced increases of phosphorylated CREB, cyclin D2 level, proliferation, and bromodeoxyuridine incorporation in keratinocytes.	Bromodeoxyuridine	163-180	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
15090535-0	2004	The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.	Estradiol	69-85	G protein-coupled estrogen receptor 1	Homo sapiens	31-36
15090535-3	2004	The c-fos response is repressed in GPR30-expressing SKBR3 cells transfected with an antisense oligonucleotide against GPR30 and reconstituted in GPR30-deficient MDA-MB 231 and BT-20 breast cancer cells transfected with a GPR30 expression vector.	Oligonucleotides	94-109	G protein-coupled estrogen receptor 1	Homo sapiens	35-40
15090535-3	2004	The c-fos response is repressed in GPR30-expressing SKBR3 cells transfected with an antisense oligonucleotide against GPR30 and reconstituted in GPR30-deficient MDA-MB 231 and BT-20 breast cancer cells transfected with a GPR30 expression vector.	Oligonucleotides	94-109	G protein-coupled estrogen receptor 1	Homo sapiens	118-123
15090535-3	2004	The c-fos response is repressed in GPR30-expressing SKBR3 cells transfected with an antisense oligonucleotide against GPR30 and reconstituted in GPR30-deficient MDA-MB 231 and BT-20 breast cancer cells transfected with a GPR30 expression vector.	Oligonucleotides	94-109	G protein-coupled estrogen receptor 1	Homo sapiens	118-123
15090535-3	2004	The c-fos response is repressed in GPR30-expressing SKBR3 cells transfected with an antisense oligonucleotide against GPR30 and reconstituted in GPR30-deficient MDA-MB 231 and BT-20 breast cancer cells transfected with a GPR30 expression vector.	Oligonucleotides	94-109	G protein-coupled estrogen receptor 1	Homo sapiens	118-123
14675202-15	2003	These effects of 17beta-estradiol may be mediated via membrane GPR30.	Estradiol	17-33	G protein-coupled estrogen receptor 1	Homo sapiens	63-68
14632195-8	2003	Antisense oligonucleotide against guanine nucleotide-binding protein-coupled receptor, GPR30 suppressed the E2-induced cyclic adenosine monophosphate signal, c-Fos expression, and nerve growth factor secretion in both types of macrophages.	Oligonucleotides	10-25	G protein-coupled estrogen receptor 1	Homo sapiens	87-92
14632195-8	2003	Antisense oligonucleotide against guanine nucleotide-binding protein-coupled receptor, GPR30 suppressed the E2-induced cyclic adenosine monophosphate signal, c-Fos expression, and nerve growth factor secretion in both types of macrophages.	Cyclic AMP	119-149	G protein-coupled estrogen receptor 1	Homo sapiens	87-92
12193550-9	2002	Interestingly, GPR30 antisense abrogated the growth inhibitory effect of progestin and progesterone.	Progesterone	87-99	G protein-coupled estrogen receptor 1	Homo sapiens	15-20
11773440-9	2002	Moreover, GPR30-dependent, cAMP-mediated attenuation of EGF-induced Erk-1/-2 activity was achieved by ER antagonists such as tamoxifen or ICI 182, 780; yet not by 17alpha-E2 or progesterone.	Tamoxifen	125-134	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
11773440-9	2002	Moreover, GPR30-dependent, cAMP-mediated attenuation of EGF-induced Erk-1/-2 activity was achieved by ER antagonists such as tamoxifen or ICI 182, 780; yet not by 17alpha-E2 or progesterone.	ici	138-141	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
11773440-9	2002	Moreover, GPR30-dependent, cAMP-mediated attenuation of EGF-induced Erk-1/-2 activity was achieved by ER antagonists such as tamoxifen or ICI 182, 780; yet not by 17alpha-E2 or progesterone.	Progesterone	177-189	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
33818655-0	2021	"Metalloestrogenic" effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells.	Cadmium	31-38	G protein-coupled estrogen receptor 1	Homo sapiens	53-88
33818655-2	2021	We have reported that Cd stimulates proliferation of estrogen-responsive human uterine leiomyoma (ht-UtLM; fibroid) cells through nongenomic signaling involving the G protein-coupled estrogen receptor (GPER), with activation of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (pMAPK44/42).	Cadmium	22-24	G protein-coupled estrogen receptor 1	Homo sapiens	165-200
33818655-2	2021	We have reported that Cd stimulates proliferation of estrogen-responsive human uterine leiomyoma (ht-UtLM; fibroid) cells through nongenomic signaling involving the G protein-coupled estrogen receptor (GPER), with activation of epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (pMAPK44/42).	Cadmium	22-24	G protein-coupled estrogen receptor 1	Homo sapiens	202-206
26638889-0	2015	MicroRNA-424 suppresses estradiol-induced cell proliferation via targeting GPER in endometrial cancer cells.	Estradiol	24-33	G protein-coupled estrogen receptor 1	Homo sapiens	75-79
33799631-0	2021	The G-Protein-Coupled Estrogen Receptor (GPER) Regulates Trimethylation of Histone H3 at Lysine 4 and Represses Migration and Proliferation of Ovarian Cancer Cells In Vitro.	Lysine	89-95	G protein-coupled estrogen receptor 1	Homo sapiens	41-45
32796699-5	2020	BPA may also affect metabolism and cancer progression, by interacting with GPR30, and may impair male reproductive function, by binding to androgen receptors.	bisphenol A	0-3	G protein-coupled estrogen receptor 1	Homo sapiens	75-80
34328988-9	2021	Based on the obtained knowledge, GPER affinity and relevant toxicity of BPA alternatives can be easily predicted, and the calculated binding free energies are consistent with the available experimental observations.	bisphenol A	72-75	G protein-coupled estrogen receptor 1	Homo sapiens	33-37
34821461-3	2022	The expression changes of four ER subtypes (ERalpha66, ERbeta, ERalpha36 and GPR30) were found to bring about tamoxifen resistance.	Tamoxifen	110-119	G protein-coupled estrogen receptor 1	Homo sapiens	77-82
34821461-5	2022	Interestingly, E2 at environmental concentrations (0.1-10 nM) could activate the expression of both ERalpha36 and GPR30, and then stimulate the phosphorylation of ERK1/2 and Akt, resulting in cell growth promotion.	Estradiol	15-17	G protein-coupled estrogen receptor 1	Homo sapiens	114-119
34821461-7	2022	Conversely, the application of specific antagonists of ERalpha36 and GPR30 could restore tamoxifen"s sensitivity as well as partially offset E2-mediated proliferation.	Tamoxifen	89-98	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
34821461-7	2022	Conversely, the application of specific antagonists of ERalpha36 and GPR30 could restore tamoxifen"s sensitivity as well as partially offset E2-mediated proliferation.	Estradiol	141-143	G protein-coupled estrogen receptor 1	Homo sapiens	69-74
34821461-8	2022	In short, overexpression of ERalpha36 and GPR30 not only ablate tamoxifen responsiveness but also could promote tumor progression of TamR breast cancer under estrogen conditions.	Tamoxifen	64-73	G protein-coupled estrogen receptor 1	Homo sapiens	42-47
34943948-0	2021	GPER Agonist G-1 Disrupts Tubulin Dynamics and Potentiates Temozolomide to Impair Glioblastoma Cell Proliferation.	Temozolomide	59-71	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
34714484-0	2021	Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.	saikosaponin D	0-14	G protein-coupled estrogen receptor 1	Homo sapiens	62-67
34403325-0	2021	Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.	kaempferol	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	19-23
34403325-10	2021	Kaempferol (5, 10 or 20 muM) induced-GPER activation increased cell viability to nearly 10%, 19.8%, 30%, and the decreased cellular reactive oxygen species (ROS) generation (16.7%, 25.6%, 31.1%), respectively, consequently attenuating postmenopausal AS.	kaempferol	0-10	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
34403325-10	2021	Kaempferol (5, 10 or 20 muM) induced-GPER activation increased cell viability to nearly 10%, 19.8%, 30%, and the decreased cellular reactive oxygen species (ROS) generation (16.7%, 25.6%, 31.1%), respectively, consequently attenuating postmenopausal AS.	Reactive Oxygen Species	132-155	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
34403325-10	2021	Kaempferol (5, 10 or 20 muM) induced-GPER activation increased cell viability to nearly 10%, 19.8%, 30%, and the decreased cellular reactive oxygen species (ROS) generation (16.7%, 25.6%, 31.1%), respectively, consequently attenuating postmenopausal AS.	Reactive Oxygen Species	157-160	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
34403325-11	2021	However, the protective effects of kaempferol were blocked through co-treatment with si-GPER.	kaempferol	35-45	G protein-coupled estrogen receptor 1	Homo sapiens	88-92
34403325-12	2021	CONCLUSIONS: The beneficial effects of kaempferol against postmenopausal AS are associated with the PI3K/AKT/Nrf2 pathways, mediated by the activation of GPER.	kaempferol	39-49	G protein-coupled estrogen receptor 1	Homo sapiens	154-158
34773076-6	2021	Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner.	Estradiol	42-58	G protein-coupled estrogen receptor 1	Homo sapiens	160-164
34773076-6	2021	Treatment of trophoblast cells with G1 or 17beta-estradiol (E2) activated Yes-associated protein (YAP), the major downstream effector of the Hippo pathway, via GPER but in a mammalian STE20-like protein kinase 1 (MST1)-independent manner.	Estradiol	60-62	G protein-coupled estrogen receptor 1	Homo sapiens	160-164
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	S-(4-bromophenyl)cysteine sulfoxide	292-295	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34600017-7	2022	Results verified that TPP could damage the structures of cell membranes and exert an agonistic effect of GPER as the molecular initiating event.	tetraphenylporphine sulfonate	22-25	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
34890987-6	2022	However, both TPhP and TDCIPP activated the estrogen pathway by GPER in SKBR3 cells which were lack of ERalpha.	triphenyl phosphate	14-18	G protein-coupled estrogen receptor 1	Homo sapiens	64-68
34890987-7	2022	Although molecular docking results revealed that both TPhP and TDCIPP could dock into ERalpha and GPER, their substituent groups and combination mode might affect the receptor activation.	triphenyl phosphate	54-58	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
34571396-4	2021	Our study showed that 17beta-estradiol (E2) significantly reduced cyclic guanosine monophosphate (cGMP) synthesis in COCs and accelerated the meiotic resumption of goat oocytes via GPER.	Estradiol	22-38	G protein-coupled estrogen receptor 1	Homo sapiens	181-185
34571396-4	2021	Our study showed that 17beta-estradiol (E2) significantly reduced cyclic guanosine monophosphate (cGMP) synthesis in COCs and accelerated the meiotic resumption of goat oocytes via GPER.	Estradiol	40-42	G protein-coupled estrogen receptor 1	Homo sapiens	181-185
34571396-6	2021	In addition, we found that E2 significantly upregulated the mRNA levels of epidermal growth (EGF)-like factors in goat cumulus cells through GPER, and activated the downstream EGF receptor (EGFR) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways.	Estradiol	27-29	G protein-coupled estrogen receptor 1	Homo sapiens	141-145
34571396-8	2021	These results indicate that, through GPER, E2 upregulates the mRNA levels of EGF-like factors in goat cumulus cells and activates the downstream EGF signaling network to suppress the expression of NPR2 protein, which results in a decrease in cGMP synthesis and acceleration of meiotic resumption in goat oocytes.	Estradiol	43-45	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
34571396-8	2021	These results indicate that, through GPER, E2 upregulates the mRNA levels of EGF-like factors in goat cumulus cells and activates the downstream EGF signaling network to suppress the expression of NPR2 protein, which results in a decrease in cGMP synthesis and acceleration of meiotic resumption in goat oocytes.	Cyclic GMP	242-246	G protein-coupled estrogen receptor 1	Homo sapiens	37-41
34781165-0	2021	The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30.	Steroids	8-15	G protein-coupled estrogen receptor 1	Homo sapiens	130-135
34781165-0	2021	The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30.	Dehydroepiandrosterone	26-48	G protein-coupled estrogen receptor 1	Homo sapiens	130-135
34781165-6	2021	Mechanistically, in vitro and in vivo studies showed that the anti-NASH function of DHEA depended on its biotransformation into estrogen rather than androgen, and which up-regulates the expression of G protein-coupled estrogen receptor (GPR30), a non-classical estrogen receptor.	Dehydroepiandrosterone	84-88	G protein-coupled estrogen receptor 1	Homo sapiens	237-242
34781165-7	2021	The activation of GPR30-mediated AMP-activated protein kinase signaling is a necessary prerequisite for the alleviative effects of DHEA on NASH.	Dehydroepiandrosterone	131-135	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
34781165-8	2021	Collectively, our data show the mechanisms of DHEA treatment and its effects on NASH that were previously overlooked; the data also show that GPR30 can be used as a target for treating lipid metabolism disorders and related diseases, such as NASH.	Dehydroepiandrosterone	46-50	G protein-coupled estrogen receptor 1	Homo sapiens	142-147
34877243-3	2021	Different studies show that down regulation of estrogen receptor beta (ERbeta) associates with GPR30 over-expression both in human testicular carcinoma in situ (CIS) and seminomas and that the mitogenic role exerted by 17beta-oestradiol induces the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) through GPR30.	Estradiol	219-236	G protein-coupled estrogen receptor 1	Homo sapiens	95-100
34877243-3	2021	Different studies show that down regulation of estrogen receptor beta (ERbeta) associates with GPR30 over-expression both in human testicular carcinoma in situ (CIS) and seminomas and that the mitogenic role exerted by 17beta-oestradiol induces the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) through GPR30.	Estradiol	219-236	G protein-coupled estrogen receptor 1	Homo sapiens	322-327
34328988-0	2021	Structural basis for molecular recognition of G protein-coupled estrogen receptor by selected bisphenols.	bis(4-hydroxyphenyl)sulfone	94-104	G protein-coupled estrogen receptor 1	Homo sapiens	46-81
34328988-1	2021	Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER).	bisphenol A	51-62	G protein-coupled estrogen receptor 1	Homo sapiens	162-197
34328988-1	2021	Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER).	bisphenol A	51-62	G protein-coupled estrogen receptor 1	Homo sapiens	199-203
34328988-1	2021	Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER).	bisphenol A	64-67	G protein-coupled estrogen receptor 1	Homo sapiens	162-197
34328988-1	2021	Complicated ligand-dependent signaling pathways of bisphenol A (BPA) and its analogues involve not only intranuclear estrogen receptor but also membrane receptor G protein-coupled estrogen receptor (GPER).	bisphenol A	64-67	G protein-coupled estrogen receptor 1	Homo sapiens	199-203
34328988-3	2021	To reveal the structural dependence of GPER recognition by bisphenols, a systematic molecular dynamics simulation study was performed for selected bisphenols with different electron hybrid orbitals and substituents on their C atoms connecting two phenol rings.	bis(4-hydroxyphenyl)sulfone	59-69	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
34328988-3	2021	To reveal the structural dependence of GPER recognition by bisphenols, a systematic molecular dynamics simulation study was performed for selected bisphenols with different electron hybrid orbitals and substituents on their C atoms connecting two phenol rings.	bis(4-hydroxyphenyl)sulfone	147-157	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
34328988-3	2021	To reveal the structural dependence of GPER recognition by bisphenols, a systematic molecular dynamics simulation study was performed for selected bisphenols with different electron hybrid orbitals and substituents on their C atoms connecting two phenol rings.	Phenol	247-253	G protein-coupled estrogen receptor 1	Homo sapiens	39-43
34328988-5	2021	All the tested bisphenols can bind with GPER at its classic orthosteric site to obtain GPER-ligand complexes, while van der Waals interactions and direct inter-molecular electrostatic energies provide the driving forces for ligand binding.	bis(4-hydroxyphenyl)sulfone	15-25	G protein-coupled estrogen receptor 1	Homo sapiens	40-44
34328988-5	2021	All the tested bisphenols can bind with GPER at its classic orthosteric site to obtain GPER-ligand complexes, while van der Waals interactions and direct inter-molecular electrostatic energies provide the driving forces for ligand binding.	bis(4-hydroxyphenyl)sulfone	15-25	G protein-coupled estrogen receptor 1	Homo sapiens	87-91
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	Hydrogen	83-91	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	bis(4-hydroxyphenyl)sulfone	121-131	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34328988-6	2021	Bulky substituents and structural rigidity of the connecting C dramatically impair hydrogen bonding between GPER and the bisphenols, which results in decreased contribution of both favorable intermolecular hydrogen bonds and unfavorable polar solvation effect to complex stability of BPB and BPC since decreased number of key residues is expected.	Hydrogen	206-214	G protein-coupled estrogen receptor 1	Homo sapiens	108-112
34768896-11	2021	This result proved that the promotional effect of BBR on the GPER1/NF-kappaB pathway was closely related to its inhibitory effect on autophagy, which may serve as a new mechanism by which to explain the inhibitory effect of BBR on MDA-MB-231 cells and expand our understanding of the function of both BBR and GPER1.	Berberine	50-53	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
34768896-11	2021	This result proved that the promotional effect of BBR on the GPER1/NF-kappaB pathway was closely related to its inhibitory effect on autophagy, which may serve as a new mechanism by which to explain the inhibitory effect of BBR on MDA-MB-231 cells and expand our understanding of the function of both BBR and GPER1.	Berberine	50-53	G protein-coupled estrogen receptor 1	Homo sapiens	309-314
34768896-9	2021	BBR could bind to GPER1 directly and change the secondary structure of GPER1, as in the case of 17beta-estradiol (E2).	Estradiol	96-112	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
34768896-9	2021	BBR could bind to GPER1 directly and change the secondary structure of GPER1, as in the case of 17beta-estradiol (E2).	Estradiol	96-112	G protein-coupled estrogen receptor 1	Homo sapiens	71-76
34768896-9	2021	BBR could bind to GPER1 directly and change the secondary structure of GPER1, as in the case of 17beta-estradiol (E2).	Estradiol	114-116	G protein-coupled estrogen receptor 1	Homo sapiens	18-23
34768896-11	2021	This result proved that the promotional effect of BBR on the GPER1/NF-kappaB pathway was closely related to its inhibitory effect on autophagy, which may serve as a new mechanism by which to explain the inhibitory effect of BBR on MDA-MB-231 cells and expand our understanding of the function of both BBR and GPER1.	Berberine	224-227	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
34363795-2	2021	It has been reported that G-1, an agonist of GPER, increases nitric oxide (NO) production through the phosphorylation of endothelial nitric oxide synthase (eNOS).	Nitric Oxide	61-73	G protein-coupled estrogen receptor 1	Homo sapiens	45-49
34768896-9	2021	BBR could bind to GPER1 directly and change the secondary structure of GPER1, as in the case of 17beta-estradiol (E2).	Estradiol	114-116	G protein-coupled estrogen receptor 1	Homo sapiens	71-76
34768896-10	2021	In addition, BBR induced not only a high degree of co-localization of GPER1 and microtubule-associated protein 1 light chain 3 (MAP1LC3), but also the accumulation of sequestosome 1 (SQSTM1/p62) by the inhibition of the nuclear translocation of the nuclear factor-kappa B (NF-kappaB) subunit (RELA/p65), which indicates NF-kappaB inhibition and anti-cancer effects.	Berberine	13-16	G protein-coupled estrogen receptor 1	Homo sapiens	70-75
34671265-0	2021	Corrigendum: Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects.	bazi bushen	13-24	G protein-coupled estrogen receptor 1	Homo sapiens	80-85
34621174-8	2021	Therefore, additional molecular effects of BPA and BPAF were unmasked after treatment with different inhibitors of well-known pivotal players of GPER-mediated signaling.	bisphenol A	43-46	G protein-coupled estrogen receptor 1	Homo sapiens	145-149
34631701-4	2021	We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner.	Estradiol	14-16	G protein-coupled estrogen receptor 1	Homo sapiens	78-115
34631701-4	2021	We found that E2 rapidly decreased the surface movement of AMPAR via membrane G protein-coupled estrogen receptor 1 (GPER1) in neurites in a dose-dependent manner.	Estradiol	14-16	G protein-coupled estrogen receptor 1	Homo sapiens	117-122
34631701-5	2021	The cortical actin network played a pivotal role in the GPER1 mediated effects of E2 on the surface mobility of AMPAR.	Estradiol	82-84	G protein-coupled estrogen receptor 1	Homo sapiens	56-61
34621174-8	2021	Therefore, additional molecular effects of BPA and BPAF were unmasked after treatment with different inhibitors of well-known pivotal players of GPER-mediated signaling.	4-boronophenylalanine-fructose	51-55	G protein-coupled estrogen receptor 1	Homo sapiens	145-149
34621174-11	2021	Indeed, a biased agonism profile for BPA and BPAF for GPER was suggested based on their different binding modes revealed by our molecular docking.	bisphenol A	37-40	G protein-coupled estrogen receptor 1	Homo sapiens	54-58
34621174-11	2021	Indeed, a biased agonism profile for BPA and BPAF for GPER was suggested based on their different binding modes revealed by our molecular docking.	4-boronophenylalanine-fructose	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	54-58
34575683-5	2021	GPR30 activation by 17beta-estradiol elicited the SRC/EGFR/PI3K/Akt/mTOR signaling pathway.	Estradiol	20-36	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34534372-5	2022	17beta-estradiol is the predominant and most biologically active endogenous estrogen, which signals through estrogen receptor alpha, estrogen receptor beta, and G protein-coupled estrogen receptor 1.	Estradiol	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	161-198
34575683-11	2021	Collectively, our results indicate that 17beta-estradiol-mediated GPR30 activation elicits the SRC/EGFR/PI3K/Akt/mTOR signaling pathway and promotes p62 phosphorylation.	Estradiol	40-56	G protein-coupled estrogen receptor 1	Homo sapiens	66-71
34575683-0	2021	GPR30 Activation by 17beta-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor alpha Protein Expression by Inducing Its Release from a Complex Formed with KEAP1.	Estradiol	20-36	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	46-62	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34329471-6	2021	In 157 paired breast cancer and adjacent normal samples, tumour suppressor gene GPER1 and miR-339 are both downregulated in Luminal A/B and Triple Negative Breast Cancer subtypes.	Phenobarbital	124-131	G protein-coupled estrogen receptor 1	Homo sapiens	80-85
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	46-62	G protein-coupled estrogen receptor 1	Homo sapiens	135-170
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	46-62	G protein-coupled estrogen receptor 1	Homo sapiens	172-176
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	64-66	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	64-66	G protein-coupled estrogen receptor 1	Homo sapiens	135-170
34330822-1	2021	GPR30 is a membrane receptor reported to bind 17beta-estradiol (E2) and mediate rapid non-genomic estrogen responses, hence also named G protein-coupled estrogen receptor (GPER).	Estradiol	64-66	G protein-coupled estrogen receptor 1	Homo sapiens	172-176
34330822-9	2021	Significance Statement Much controversy surrounds E2 and G-1 as GPR30 agonists.	Estradiol	50-52	G protein-coupled estrogen receptor 1	Homo sapiens	64-69
34085740-10	2021	GPER was significantly increased in active patients and correlated with BPA levels.	bisphenol A	72-75	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
34646075-8	2021	GPER-1 knockdown by siRNA reduced the cells number to 60% of siRNA-control-treated cells (P < .05), and GPER-1 antagonist, G-15 inhibited two HGSC cell lines proliferation (KF and UWB1.289) in a dose-dependent manner.	G-15	123-127	G protein-coupled estrogen receptor 1	Homo sapiens	104-110
34244306-7	2021	Through multiplexed RNA profiling analysis of 4-OHT-treated ER+ and ER- cells, we identified increased activation of apoptotic and death receptor signaling pathways and identified G protein-coupled receptor for estrogen (GPR30) engagement as a putative mechanism for immunogenic modulation.	4,17 beta-dihydroxy-4-androstene-3-one	46-51	G protein-coupled estrogen receptor 1	Homo sapiens	221-226
34182538-0	2021	GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERalpha-positive breast cancer cells.	Tamoxifen	64-73	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34182538-5	2021	GPR30-induced HMGB1 upregulation triggered MEK/ERK signaling, leading to increased autophagic behavior to protect cancer cells from TAM-induced apoptosis, mimicking the recombinant HMGB1-mediated increase in cancer cell resistance potential to TAM.	Tamoxifen	244-247	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34182538-2	2021	G-protein-coupled estrogen receptor (GPR30/GPER), which reportedly initiates TAM resistance in ERalpha+/ GPR30+ breast cancers, is detected in the breast cancer microenvironment, especially cancer associated fibroblasts (CAFs).	Tamoxifen	77-80	G protein-coupled estrogen receptor 1	Homo sapiens	37-42
34182538-7	2021	CAF-expressed GPR30 induced TAM resistance via HMGB1 in vivo.	Tamoxifen	28-31	G protein-coupled estrogen receptor 1	Homo sapiens	14-19
34182538-8	2021	Overall, TAM upregulated HMGB1 expression and secretion in CAFs via GPR30/PI3K/AKT signaling, and the secreted HMGB1 induced autophagy to enhance TAM resistance in MCF-7 cells in an ERK-dependent manner.	Tamoxifen	9-12	G protein-coupled estrogen receptor 1	Homo sapiens	68-73
34182538-2	2021	G-protein-coupled estrogen receptor (GPR30/GPER), which reportedly initiates TAM resistance in ERalpha+/ GPR30+ breast cancers, is detected in the breast cancer microenvironment, especially cancer associated fibroblasts (CAFs).	Tamoxifen	77-80	G protein-coupled estrogen receptor 1	Homo sapiens	43-47
34182538-2	2021	G-protein-coupled estrogen receptor (GPR30/GPER), which reportedly initiates TAM resistance in ERalpha+/ GPR30+ breast cancers, is detected in the breast cancer microenvironment, especially cancer associated fibroblasts (CAFs).	Tamoxifen	77-80	G protein-coupled estrogen receptor 1	Homo sapiens	105-110
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Estradiol	309-326	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Estradiol	309-326	G protein-coupled estrogen receptor 1	Homo sapiens	236-241
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Estradiol	309-326	G protein-coupled estrogen receptor 1	Homo sapiens	350-355
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Estradiol	327-329	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Estradiol	327-329	G protein-coupled estrogen receptor 1	Homo sapiens	236-241
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Tamoxifen	336-339	G protein-coupled estrogen receptor 1	Homo sapiens	25-30
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Tamoxifen	336-339	G protein-coupled estrogen receptor 1	Homo sapiens	236-241
34182538-3	2021	Herein, considering that GPR30 mediates transcriptional regulation in different cell backgrounds, a microarray strategy was applied in immortalized CAFs derived from primary breast cancer samples, resulting in the identification of 165 GPR30 target genes, among which HMGB1 was confirmed to be upregulated by 17-beta estradiol(E2)- and TAM-triggered GPR30 activation in CAFs.	Tamoxifen	336-339	G protein-coupled estrogen receptor 1	Homo sapiens	350-355
34182538-4	2021	Activated GPR30 increased extracellular HMGB1 secretion by CAFs, which was reduced by blocking PI3K/AKT signaling using G15 or LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	127-135	G protein-coupled estrogen receptor 1	Homo sapiens	10-15
34182538-5	2021	GPR30-induced HMGB1 upregulation triggered MEK/ERK signaling, leading to increased autophagic behavior to protect cancer cells from TAM-induced apoptosis, mimicking the recombinant HMGB1-mediated increase in cancer cell resistance potential to TAM.	Tamoxifen	132-135	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
34239558-6	2021	Suppression of MR did not influence GPER1 expression, and GPER1 was capable of mediating part of aldosterone-induced endothelial inflammatory response.	Aldosterone	97-108	G protein-coupled estrogen receptor 1	Homo sapiens	58-63
34248622-6	2021	In si-GPER1-treated HUVECs, the anti-apoptotic effect of BZBS was decreased.	bzbs	57-61	G protein-coupled estrogen receptor 1	Homo sapiens	6-11
34248622-7	2021	This study revealed that BZBS exhibited a clear effect against atherogenesis via GPER1-dependent anti-inflammatory and anti-apoptotic mechanisms.	bzbs	25-29	G protein-coupled estrogen receptor 1	Homo sapiens	81-86
34248622-0	2021	Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects.	bazi bushen	0-11	G protein-coupled estrogen receptor 1	Homo sapiens	67-72
34205363-4	2021	In addition to the MR, aldosterone can bind and stimulate other receptors, such as the plasma membrane-residing G protein-coupled estrogen receptor (GPER), further complicating it signaling properties in the myocardium.	Aldosterone	23-34	G protein-coupled estrogen receptor 1	Homo sapiens	112-147
34205363-4	2021	In addition to the MR, aldosterone can bind and stimulate other receptors, such as the plasma membrane-residing G protein-coupled estrogen receptor (GPER), further complicating it signaling properties in the myocardium.	Aldosterone	23-34	G protein-coupled estrogen receptor 1	Homo sapiens	149-153
34239558-0	2021	G Protein-Coupled Estrogen Receptor 1 (GPER1) Mediates Aldosterone-Induced Endothelial Inflammation in a Mineralocorticoid Receptor-Independent Manner.	Aldosterone	55-66	G protein-coupled estrogen receptor 1	Homo sapiens	0-37
34239558-0	2021	G Protein-Coupled Estrogen Receptor 1 (GPER1) Mediates Aldosterone-Induced Endothelial Inflammation in a Mineralocorticoid Receptor-Independent Manner.	Aldosterone	55-66	G protein-coupled estrogen receptor 1	Homo sapiens	39-44
34239558-3	2021	However, whether GPER1 mediates aldosterone-induced inflammation response in endothelial cells and its relationship with MR are yet undetermined and therefore require further explanation.	Aldosterone	32-43	G protein-coupled estrogen receptor 1	Homo sapiens	17-22
34239558-8	2021	Conclusion: These findings not only demonstrated the role of GPER1 in aldosterone-induced vascular inflammation but also suggested an alternative for pharmaceutical treatment of hyperaldosteronism considering the unsatisfying effect on cardiovascular risks with MR antagonists.	Aldosterone	70-81	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
34602561-4	2021	However, the effects of BPA/MBP on GPER1, have not yet been fully resolved.	bisphenol A	24-27	G protein-coupled estrogen receptor 1	Homo sapiens	35-40
35245871-7	2022	Therefore, TCS acts on GPER to activate the downstream PKC/MAPK signaling pathway, further up-regulating miR-144 expression and causing abnormal modulation of these nerve-related genes to trigger neurodevelopmental toxicity.	Triclosan	11-14	G protein-coupled estrogen receptor 1	Homo sapiens	23-27
34602561-0	2021	4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) Targets Estrogen Receptor beta, to Evoke the Resistance of Human Breast Cancer MCF-7 Cells to G-1, an Agonist for G Protein-Coupled Estrogen Receptor 1.	4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene	0-43	G protein-coupled estrogen receptor 1	Homo sapiens	164-201
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	46-55	G protein-coupled estrogen receptor 1	Homo sapiens	110-154
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	46-55	G protein-coupled estrogen receptor 1	Homo sapiens	156-160
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	46-55	G protein-coupled estrogen receptor 1	Homo sapiens	278-282
35537249-6	2022	We demonstrated that GPER1 and OXTR aggregates might be formed due to interactions with GAGs rather than arising from changes of levels of these proteins in cells.	Glycosaminoglycans	88-92	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	110-154
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	156-160
35245871-1	2022	Although the previous research confirmed that triclosan (TCS) induced an estrogen effect by acting on a novel G-protein coupled estrogen-membrane receptor (GPER), the underlying mechanisms by which downstream pathways induce neurotoxicity remain unclear after TCS activation of GPER.	Triclosan	57-60	G protein-coupled estrogen receptor 1	Homo sapiens	278-282
35326671-0	2022	27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer.	27-hydroxycholesterol	0-21	G protein-coupled estrogen receptor 1	Homo sapiens	28-32
35440074-0	2022	Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages.	Dehydroepiandrosterone	0-22	G protein-coupled estrogen receptor 1	Homo sapiens	91-95
35440074-0	2022	Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages.	Nigericin	35-44	G protein-coupled estrogen receptor 1	Homo sapiens	91-95
35326671-10	2022	Collectively, these data demonstrate that cholesterol conversion into 27HC promotes ER- BC growth and progression, and the expression of GPER is required for its effects.	Cholesterol	42-53	G protein-coupled estrogen receptor 1	Homo sapiens	137-141
35446883-8	2022	Additionally, using gene ontology enrichment analysis, we demonstrated for timolol a significant enrichment in 23 pathways, 19 of them including either GPER1 or PDE4B.	Timolol	75-82	G protein-coupled estrogen receptor 1	Homo sapiens	152-157
35446883-9	2022	In the case of carvedilol, we showed that, beside genes with well-established association with hypertension (GPER1, PDE4B and TNFAIP3), the drug also affects genes that are only indirectly linked to hypertension due to their effects on artery walls or their role in lipid biosynthesis.	Carvedilol	15-25	G protein-coupled estrogen receptor 1	Homo sapiens	109-114
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	153-157	G protein-coupled estrogen receptor 1	Homo sapiens	68-103
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	153-157	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	153-157	G protein-coupled estrogen receptor 1	Homo sapiens	205-209
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Nigericin	161-164	G protein-coupled estrogen receptor 1	Homo sapiens	68-103
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Nigericin	161-164	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Nigericin	161-164	G protein-coupled estrogen receptor 1	Homo sapiens	205-209
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	347-351	G protein-coupled estrogen receptor 1	Homo sapiens	68-103
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	347-351	G protein-coupled estrogen receptor 1	Homo sapiens	105-109
35440074-8	2022	Mechanistically, the present study certified that the activation of G protein-coupled estrogen receptor (GPER) signal mediated the cell death induced by DHEA in Nig-stimulated inflammatory macrophages, as GPER specific inhibitor G15 alleviated the abnormal autophagy and ultimately prevented the gasdermin D (GSDMD)-mediated pyroptosis induced by DHEA.	Dehydroepiandrosterone	347-351	G protein-coupled estrogen receptor 1	Homo sapiens	205-209
35440074-9	2022	Collectively, DHEA can exacerbate Nig-induced abnormal autophagy and pyroptosis via activation of GPER in LPS-primed macrophages, which prompts us the potential application value of DHEA in anti-infection or anti-tumor immunity.	Dehydroepiandrosterone	14-18	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
35440074-9	2022	Collectively, DHEA can exacerbate Nig-induced abnormal autophagy and pyroptosis via activation of GPER in LPS-primed macrophages, which prompts us the potential application value of DHEA in anti-infection or anti-tumor immunity.	Nigericin	34-37	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
35440074-9	2022	Collectively, DHEA can exacerbate Nig-induced abnormal autophagy and pyroptosis via activation of GPER in LPS-primed macrophages, which prompts us the potential application value of DHEA in anti-infection or anti-tumor immunity.	Dehydroepiandrosterone	182-186	G protein-coupled estrogen receptor 1	Homo sapiens	98-102
35519261-3	2022	The biosensor is made by an 18  TFBG with a 50 nm-thick gold nanofilm coating over the surface of the fiber, further immobilized with a specific antibody against GPR30, which is a membrane receptor expressed in many breast cancers, serving as bait.	TFBG	32-36	G protein-coupled estrogen receptor 1	Homo sapiens	162-167
35122788-10	2022	In addition, DHEA may interact with the G-protein coupled receptor GPER for stimulation of miR-21 and subsequent activation of the MAPK pathway.	Dehydroepiandrosterone	13-17	G protein-coupled estrogen receptor 1	Homo sapiens	67-71
35337112-7	2022	Tamoxifen is a known agonist of GPER1, a receptor that can promote tumor progression.	Tamoxifen	0-9	G protein-coupled estrogen receptor 1	Homo sapiens	32-37
35237599-9	2022	The observed cytotoxic effects, apparently, were not triggered by the interaction of G-1 with the GPER as pre-incubation with the highly selective GPER antagonist G-36 was ineffective in preventing the cytotoxicity of G-1.	G-36	163-167	G protein-coupled estrogen receptor 1	Homo sapiens	147-151
35170266-3	2022	The role of G protein-coupled estrogen receptor (GPR30), which mediates the non-genomic effects of E2, is mostly unexplored.	Estradiol	99-101	G protein-coupled estrogen receptor 1	Homo sapiens	49-54
35242036-9	2022	Ovarian cancer tumor tissues chronically (30 days) treated with JWH-133 in comparison to vehicle treated groups showed an increase in endocannabinoid (AEA and 2-AG) and protein (CB2 and TNFalpha) levels with a decrease in GPER protein levels.	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	64-71	G protein-coupled estrogen receptor 1	Homo sapiens	222-226
35061800-0	2022	Cryptotanshinone inhibits proliferation and induces apoptosis of breast cancer MCF-7 cells via GPER mediated PI3K/AKT signaling pathway.	cryptotanshinone	0-16	G protein-coupled estrogen receptor 1	Homo sapiens	95-99
35061800-2	2022	This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and antiproliferation effect on GPER positive breast cancer MCF-7 cells.	cryptotanshinone	89-105	G protein-coupled estrogen receptor 1	Homo sapiens	47-51
35061800-2	2022	This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and antiproliferation effect on GPER positive breast cancer MCF-7 cells.	cryptotanshinone	107-110	G protein-coupled estrogen receptor 1	Homo sapiens	47-51
35061800-2	2022	This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and antiproliferation effect on GPER positive breast cancer MCF-7 cells.	cryptotanshinone	89-105	G protein-coupled estrogen receptor 1	Homo sapiens	168-172
35061800-2	2022	This study aimed to illuminate the function of GPER and its mediated PI3K/AKT pathway in cryptotanshinone (CPT) inducing cell apoptosis and antiproliferation effect on GPER positive breast cancer MCF-7 cells.	cryptotanshinone	107-110	G protein-coupled estrogen receptor 1	Homo sapiens	168-172
35061800-5	2022	Autodock vina was applied to make molecular docking between CPT or estradiol and GPER.	Estradiol	67-76	G protein-coupled estrogen receptor 1	Homo sapiens	81-85
35096058-4	2022	In this study, we aim to evaluate the clinical relevance of GPR30 expression in GC patients and the role of the GPR30/PI3K/AKT signalling pathway in the anti-GC effect of NEH.	neh	171-174	G protein-coupled estrogen receptor 1	Homo sapiens	112-117
35096058-13	2022	Furthermore, NEH inhibited the proliferation, migration, and invasion in GC cells in a concentration-dependent manner through inhibiting the GPR30-mediated PI3K/AKT signalling pathway in vitro.	neh	13-16	G protein-coupled estrogen receptor 1	Homo sapiens	141-146