PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33377585-9	2021	Furthermore, IL-1beta stimulation significantly increased the phosphorylation levels of NF-kappaB p65 and GSK-3beta, and decreased the phosphorylation levels of beta-catenin in articular chondrocytes, and these alterations to the phosphorylation levels were partly reversed by treatment with curcumin.	Curcumin	292-300	catenin beta 1	Rattus norvegicus	161-173
33723718-0	2021	Wnt/beta-Catenin Antagonist Pyrvinium Exerts Cardioprotective Effects in Polymicrobial Sepsis Model by Attenuating Calcium Dyshomeostasis and Mitochondrial Dysfunction.	pyrvinium	28-37	catenin beta 1	Rattus norvegicus	4-16
33723718-9	2021	Pre-treatment with Wnt/beta-Catenin antagonist attenuated sepsis-induced serum and tissue biochemical changes, cardiac dysfunction and structural alterations by inhibiting mitochondrial mPTP opening and restricting calcium overloading in cardiac tissue.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	186-190	catenin beta 1	Rattus norvegicus	23-35
33723718-9	2021	Pre-treatment with Wnt/beta-Catenin antagonist attenuated sepsis-induced serum and tissue biochemical changes, cardiac dysfunction and structural alterations by inhibiting mitochondrial mPTP opening and restricting calcium overloading in cardiac tissue.	Calcium	215-222	catenin beta 1	Rattus norvegicus	23-35
33662519-8	2021	Femoral pro-osteoclastic gene expression of Dkk1 was lower (P=0.0006) and pro-osteoblastic gene expression of Ctnnb1 was higher (P=0.02) with ethanol consumption.	Ethanol	142-149	catenin beta 1	Rattus norvegicus	110-116
34016181-0	2021	Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/beta-catenin pathway.	strontium ranelate	0-18	catenin beta 1	Rattus norvegicus	73-85
34016181-11	2021	XAV-939, an inhibitor of beta-catenin, significantly promoted chondrogenesis, and SrR did not suppress this effect, while LiCl, an agonist of beta-catenin, strongly suppressed chondrogenesis, and SrR reversed this inhibitory effect.	XAV939	0-7	catenin beta 1	Rattus norvegicus	25-37
34016181-11	2021	XAV-939, an inhibitor of beta-catenin, significantly promoted chondrogenesis, and SrR did not suppress this effect, while LiCl, an agonist of beta-catenin, strongly suppressed chondrogenesis, and SrR reversed this inhibitory effect.	Lithium Chloride	122-126	catenin beta 1	Rattus norvegicus	142-154
34016181-12	2021	In vivo study showed a significantly better cartilage regeneration and a lower activation level of beta-catenin by SrR-loaded GelMA than the other treatments.	strontium ranelate	115-118	catenin beta 1	Rattus norvegicus	99-111
34000860-8	2021	These results found that magnesium and strontium ion-loaded mineralized collagen play an critical role in up-regulating the cells activity through PI3K/AKT/GSK3beta/beta-catenin signaling pathway and could be promote the formation of osseointegration.	Magnesium	25-34	catenin beta 1	Rattus norvegicus	165-177
34000860-8	2021	These results found that magnesium and strontium ion-loaded mineralized collagen play an critical role in up-regulating the cells activity through PI3K/AKT/GSK3beta/beta-catenin signaling pathway and could be promote the formation of osseointegration.	Strontium	39-48	catenin beta 1	Rattus norvegicus	165-177
33078406-0	2021	beta-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats.	Methotrexate	90-102	catenin beta 1	Rattus norvegicus	0-12
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Dextromethorphan	194-197	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	22-33	catenin beta 1	Rattus norvegicus	88-100
33078406-8	2021	Thus, beta-catenin signaling is important for osteogenesis and hematopoiesis recoveries following MTX chemotherapy.	Methotrexate	98-101	catenin beta 1	Rattus norvegicus	6-18
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Dextromethorphan	194-197	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	22-33	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Dextromethorphan	150-153	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Dextromethorphan	194-197	catenin beta 1	Rattus norvegicus	88-100
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Sevoflurane	138-149	catenin beta 1	Rattus norvegicus	256-268
33966704-4	2021	Compared with that in sevoflurane group,the protein levels of Wnt3a(t=6.410,P=0.003)and beta-catenin(t=4.640,P=0.015)were up-regulated in sevoflurane+Dex group.Compared with that in sevoflurane+Dex group,the protein expression of Wnt3a(t=6.360,P=0.003)and beta-catenin(t=4.640,P=0.016)was down-regulated in sevoflurane+Dex+Wnt inhibitor group.Compared with that in the control group,the expression(gray value)of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane group(t=11.280,P=0.002),sevoflurane+Dex group(t=7.080,P=0.002),and sevoflurane+Dex+Wnt inhibitor group(t=9.970,P=0.001)were down-regulated.Compared with that in the sevoflurane group,the expression of P(ser9)-GSK-3beta/GSK-3beta were up-regulated in sevoflurane+Dex group(t=8.310,P <0.001).Compared with that in sevoflurane+Dex group,the expression of P(ser9)-GSK-3beta/GSK-3beta in sevoflurane+Dex+Wnt inhibitor group was down-regulated(t=5.510,P=0.005).	Dextromethorphan	194-197	catenin beta 1	Rattus norvegicus	88-100
33966704-5	2021	Conclusion Dex can mediate Wnt/GSK-3beta/beta-catenin signaling pathway to inhibit sevoflurane-induced cognitive impairment in neonatal rats.	Dextromethorphan	11-14	catenin beta 1	Rattus norvegicus	41-53
33966704-5	2021	Conclusion Dex can mediate Wnt/GSK-3beta/beta-catenin signaling pathway to inhibit sevoflurane-induced cognitive impairment in neonatal rats.	Sevoflurane	83-94	catenin beta 1	Rattus norvegicus	41-53
33875647-0	2021	Overexpression of circRNA SNRK targets miR-103-3p to reduce apoptosis and promote cardiac repair through GSK3beta/beta-catenin pathway in rats with myocardial infarction.	mir-103-3p	39-49	catenin beta 1	Rattus norvegicus	114-126
33857573-12	2021	In vivo experiments further showed that miR-497-5p-containing BMSC-EVs enhanced OPLL through diminishing RSPO2 and inactivating Wnt/beta-catenin pathway.	bmsc-evs	62-70	catenin beta 1	Rattus norvegicus	132-144
33866492-10	2021	The beta-catenin expression in LECs was downregulated (p < 0.05) by MBG and CINO.	marinobufagenin	68-71	catenin beta 1	Rattus norvegicus	4-16
33866492-10	2021	The beta-catenin expression in LECs was downregulated (p < 0.05) by MBG and CINO.	cinobufotalin	76-80	catenin beta 1	Rattus norvegicus	4-16
33927614-6	2021	Based on the results of gene expression profiling and subsequent pathway analysis, we found that several canonical pathways were linked to DAE treatment, including WNT/beta-catenin signaling.	o,p-dinitrophenyl aminoethyldiphosphate-beryllium trifluoride	139-142	catenin beta 1	Rattus norvegicus	168-180
33959159-7	2021	Additionally, rats had obvious mechanical induced pain after CCD surgery and the pain was significantly alleviated after the application of the Wnt/beta-catenin pathway inhibitor XAV939.	XAV939	179-185	catenin beta 1	Rattus norvegicus	148-160
33000666-0	2021	IGF-1R/beta-catenin signaling axis is implicated in streptozotocin exacerbating bone impairment in ovariectomized rats.	Streptozocin	52-66	catenin beta 1	Rattus norvegicus	7-19
33645251-8	2021	In conclusion, our data demonstrated that API could promote osteogenesis in vitro and facilitate the fracture healing in vivo via activating Wnt/beta-catenin signaling, indicating that API may be a promising therapeutic candidate for bone fracture repair.	Apigenin	42-45	catenin beta 1	Rattus norvegicus	145-157
33645251-8	2021	In conclusion, our data demonstrated that API could promote osteogenesis in vitro and facilitate the fracture healing in vivo via activating Wnt/beta-catenin signaling, indicating that API may be a promising therapeutic candidate for bone fracture repair.	Apigenin	185-188	catenin beta 1	Rattus norvegicus	145-157
33000666-10	2021	Compared with OVX, more serious bone damage was found in the OVX + STZ group, which showed enhanced phosphorylation of IGF-1R, GSK-3beta, and beta-catenin.	Streptozocin	67-70	catenin beta 1	Rattus norvegicus	142-154
33000666-11	2021	CONCLUSION: OVX plus STZ induced more serious bone impairment than OVX alone, which involves the IGF-1R/beta-catenin signaling axis in the pathogenesis.	Streptozocin	21-24	catenin beta 1	Rattus norvegicus	104-116
33350534-0	2021	Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, beta-catenin.	Quercetin	0-9	catenin beta 1	Rattus norvegicus	197-209
33717238-0	2021	Ethylparaben induces subconjunctival fibrosis via the Wnt/beta-catenin signaling pathway.	ethyl-p-hydroxybenzoate	0-12	catenin beta 1	Rattus norvegicus	58-70
33717238-6	2021	Furthermore, stimulation of the Wnt/beta-catenin axis triggered by ethylparaben was impaired by XAV-939.	ethyl-p-hydroxybenzoate	67-79	catenin beta 1	Rattus norvegicus	36-48
33717238-6	2021	Furthermore, stimulation of the Wnt/beta-catenin axis triggered by ethylparaben was impaired by XAV-939.	XAV939	96-99	catenin beta 1	Rattus norvegicus	36-48
33717238-7	2021	In conclusion, SCF triggered by ethylparaben results from extra ECM generation of conjunctival fibroblasts via the Wnt/beta-catenin axis.	ethyl-p-hydroxybenzoate	32-44	catenin beta 1	Rattus norvegicus	119-131
33350534-3	2021	Our study was designed to investigate the effect of quercetin on DMH-mediated colon cancer by targeting adenomatous polyposis coli (APC) and beta-catenin in Wistar rats.	Dimethylhydrazines	65-68	catenin beta 1	Rattus norvegicus	141-153
33350534-2	2021	Previous reports suggest that DMH-mediated dysregulation of the Wnt/beta-catenin pathway plays a vital role in the initial events of colon carcinogenesis.	Dimethylhydrazines	30-33	catenin beta 1	Rattus norvegicus	68-80
33350534-3	2021	Our study was designed to investigate the effect of quercetin on DMH-mediated colon cancer by targeting adenomatous polyposis coli (APC) and beta-catenin in Wistar rats.	Quercetin	52-61	catenin beta 1	Rattus norvegicus	141-153
33655472-7	2021	The inhibition of beta-catenin signal and the improvement of pulmonary arterial EMT may provide therapeutic ideas for CTEPH.	cteph	118-123	catenin beta 1	Rattus norvegicus	18-30
33712069-0	2021	Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/beta-catenin pathway and prevents bone loss in an ovariectomized rat model.	morusin	0-7	catenin beta 1	Rattus norvegicus	98-110
33712069-7	2021	The effect of Morusin on Wnt/beta-catenin signaling pathway was analyzed by RT-qPCR, Western blotting, and immunofluorescence.	morusin	14-21	catenin beta 1	Rattus norvegicus	29-41
33712069-11	2021	Upon Dickkopf-related protein-1 (DKK-1, an inhibitor of the Wnt/beta-catenin signaling pathway) was added to the Morusin, Morusin had a decreased stimulatory osteogenic effect on BMSCs.	morusin	122-129	catenin beta 1	Rattus norvegicus	64-76
33712069-13	2021	CONCLUSIONS: This study indicates the ability of Morusin in the promotion of osteogenic differentiation of BMSCs via the activation of Wnt/beta-catenin signaling pathway and also shows the potential of Morusin to be an agent for osteoporosis treatment.	morusin	49-56	catenin beta 1	Rattus norvegicus	139-151
33911930-0	2021	Neurokinin-1-tachykinin receptor agonist promotes diabetic fracture healing in rats with type 1 diabetes via modulation of Wnt/beta-catenin signalling axis.	neurokinin-1-tachykinin	0-23	catenin beta 1	Rattus norvegicus	127-139
33482150-15	2021	In conclusion, this study proved, for the first time, the inhibitory effect of IFX on renal Wnt/beta-catenin signaling in DOX-induced nephropathy in vivo by up-regulating renal klotho.	Doxorubicin	122-125	catenin beta 1	Rattus norvegicus	96-108
33596312-8	2021	SAPH treatment also decreased colonic expression of interleukin (IL)-1alpha (P = 0.0233) and IL-6 (P = 0.0343) and increased that of claudin-1 (P = 0.0486), villin (P = 0.0183), and beta-catenin staining (P = 0.0237).	saph	0-4	catenin beta 1	Rattus norvegicus	182-194
33788101-3	2021	At this age, zona reticularis was characterized with overexpression of beta-catenin by steroid-producing cells; a high percentage of cells with membrane and cytoplasmic localization of beta-catenin, and reduced number of cells with nuclear beta-catenin attesting to insufficient activation of Wnt signaling.	Steroids	87-94	catenin beta 1	Rattus norvegicus	71-83
33829697-1	2021	Objective: To explore the influence for combination of Dingkun Dan with estradiol valerateon in treating rats with thin endometrium with Kidney-Yang deficiency based on Wnt/beta-catenin signaling pathway.	Estradiol	72-81	catenin beta 1	Rattus norvegicus	173-185
33829697-12	2021	Compared with the estradiol valerateon group, the level of beta-catenin in Dingkun Dan group was higher, and MMP-9 was lower ( P<0.05 or P<0.01).	Estradiol	18-27	catenin beta 1	Rattus norvegicus	59-71
33829697-15	2021	Conclusion: Dingkun Dan combined with estradiol valerateon can increase the thicken of the endometrium by up-regulation of VEGF, while down-regulate of beta-catenin, E-cadherin and MMP-9 in rats with Shen-Yang deficiency and thin endometrium.	Estradiol	38-47	catenin beta 1	Rattus norvegicus	152-164
33679423-14	2020	Our results provide the first evidence that QYDP performs its renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats.	qydp	44-48	catenin beta 1	Rattus norvegicus	110-122
33482150-4	2021	We aimed to investigate the impact of IFX on Wnt/beta-catenin pathway in doxorubicin (DOX)-induced nephropathy.	Doxorubicin	73-84	catenin beta 1	Rattus norvegicus	49-61
33482150-4	2021	We aimed to investigate the impact of IFX on Wnt/beta-catenin pathway in doxorubicin (DOX)-induced nephropathy.	Doxorubicin	86-89	catenin beta 1	Rattus norvegicus	49-61
33482150-7	2021	DOX decreased the renal expression of klotho which in turn increased Wnt1, active beta-catenin/total beta-catenin ratio in renal tissue.	Doxorubicin	0-3	catenin beta 1	Rattus norvegicus	82-94
33482150-7	2021	DOX decreased the renal expression of klotho which in turn increased Wnt1, active beta-catenin/total beta-catenin ratio in renal tissue.	Doxorubicin	0-3	catenin beta 1	Rattus norvegicus	101-113
33679423-13	2020	QYDP reduced the renal Wnt1, catenin beta1, Tgfb1, and Smad2 gene expression and beta-catenin, TGF-beta, Smad2, collagen I, alpha-smooth muscle actin, and fibronectin protein expression in diabetic rats.	qydp	0-4	catenin beta 1	Rattus norvegicus	29-42
33679423-13	2020	QYDP reduced the renal Wnt1, catenin beta1, Tgfb1, and Smad2 gene expression and beta-catenin, TGF-beta, Smad2, collagen I, alpha-smooth muscle actin, and fibronectin protein expression in diabetic rats.	qydp	0-4	catenin beta 1	Rattus norvegicus	81-93
33359712-11	2021	Additionally, the expression levels of Wnt and p-beta-catenin, apoptosis of GCs decreased after NAC treatment.	Acetylcysteine	96-99	catenin beta 1	Rattus norvegicus	49-61
33359712-12	2021	In summary, polystyrene microplastics cause fibrosis via Wnt/beta-Catenin signaling pathway activation and granulosa cells apoptosis of ovary through oxidative stress in rats, both of which ultimately resulted in decrease of ovarian reserve capacity.	Polystyrenes	12-23	catenin beta 1	Rattus norvegicus	61-73
33359712-10	2021	Moreover, the western blot assay manifested that PS-MPs exposure significantly increased the expression levels of Wnt/beta-Catenin signaling pathways-related proteins (Wnt, beta-catenin, p-beta-catenin) and the main fibrosis markers (transforming growth factor-beta (TGF-beta), fibronectin, alpha-smooth muscle actin (alpha-SMA).	ps-mps	49-55	catenin beta 1	Rattus norvegicus	118-130
33359712-10	2021	Moreover, the western blot assay manifested that PS-MPs exposure significantly increased the expression levels of Wnt/beta-Catenin signaling pathways-related proteins (Wnt, beta-catenin, p-beta-catenin) and the main fibrosis markers (transforming growth factor-beta (TGF-beta), fibronectin, alpha-smooth muscle actin (alpha-SMA).	ps-mps	49-55	catenin beta 1	Rattus norvegicus	173-185
33359712-10	2021	Moreover, the western blot assay manifested that PS-MPs exposure significantly increased the expression levels of Wnt/beta-Catenin signaling pathways-related proteins (Wnt, beta-catenin, p-beta-catenin) and the main fibrosis markers (transforming growth factor-beta (TGF-beta), fibronectin, alpha-smooth muscle actin (alpha-SMA).	ps-mps	49-55	catenin beta 1	Rattus norvegicus	189-201
33544723-9	2021	Conversely, in LP CM and UB, beta-catenin was 154%, and 85% increased, respectively.	Curium	18-20	catenin beta 1	Rattus norvegicus	29-41
33544723-9	2021	Conversely, in LP CM and UB, beta-catenin was 154%, and 85% increased, respectively.	BM	25-27	catenin beta 1	Rattus norvegicus	29-41
33113278-6	2021	In addition, OVX-induced reduction of Lrp-5, beta-catenin, Runx2, and Osx protein expression was all restored by glabrene treatment.	glabrene	113-121	catenin beta 1	Rattus norvegicus	45-57
33574696-12	2021	Conclusion: This study suggests that exosomal miR-127-3p derived from BM-MSCs inhibits CDH11 in chondrocytes, thereby blocking the Wnt/beta-catenin pathway activation and relieving chondrocyte damage in OA.	mir-127-3p	46-56	catenin beta 1	Rattus norvegicus	135-147
33348309-0	2021	Dimethyl fumarate protects against intestinal ischemia/reperfusion lesion: Participation of Nrf2/HO-1, GSK-3beta and Wnt/beta-catenin pathway.	Dimethyl Fumarate	0-17	catenin beta 1	Rattus norvegicus	121-133
33348309-6	2021	In addition, DMFU lessened GSK-3beta expression/content accompanied by enriching beta-catenin expression/content.	Dimethyl Fumarate	13-17	catenin beta 1	Rattus norvegicus	81-93
33113278-0	2021	The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt/beta-catenin signaling pathway.	glabrene	18-26	catenin beta 1	Rattus norvegicus	114-126
33113278-7	2021	The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt/beta-catenin signaling pathway.	glabrene	33-41	catenin beta 1	Rattus norvegicus	174-186
33278748-0	2021	Acetazolamide ameliorates the severity of collagen-induced arthritis in rats: Involvement of inducing synovial apoptosis and inhibiting Wnt/beta-catenin pathway.	Acetazolamide	0-13	catenin beta 1	Rattus norvegicus	140-152
33501725-0	2021	Curcumin regulates EZH2/Wnt/beta-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	28-40
33501725-10	2021	Curcumin inhibited EZH2 mRNA level and induced that of beta-Catenin and Runx2 in the mandible and femur.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	55-67
33501725-11	2021	Collectively, curcumin exerts protective effects against OP, possibly by regulating the EZH2/Wnt/beta-Catenin pathway.	Curcumin	14-22	catenin beta 1	Rattus norvegicus	97-109
33462795-0	2021	The GSK-3beta/beta-Catenin Signaling-Mediated Brain-Derived Neurotrophic Factor Pathway Is Involved in Aluminum-Induced Impairment of Hippocampal LTP In Vivo.	Aluminum	103-111	catenin beta 1	Rattus norvegicus	14-26
33462795-7	2021	Electrophysiology and western blot analysis were used to investigate the regulatory effect of the GSK-3beta/beta-catenin signaling-mediated BDNF pathway on LTP impairment induced by Al(mal)3.	al(mal)3	182-190	catenin beta 1	Rattus norvegicus	108-120
33462795-9	2021	injection of Al(mal)3 significantly suppressed the field excitatory postsynaptic potential (fEPSP) amplitude, as indicated by a decrease in BDNF protein expression, which was accompanied by dose-dependent decreases in beta-catenin protein expression and the phosphorylation of GSK-3beta at Ser9.	al(mal)3	13-21	catenin beta 1	Rattus norvegicus	218-230
33462795-11	2021	Furthermore, SB216763 treatment upregulated the hippocampal protein expression of BDNF and beta-catenin while increasing the ratio of p-GSK-3beta/GSK-3beta.	SB 216763	13-21	catenin beta 1	Rattus norvegicus	91-103
33462795-12	2021	From the perspective of the identified beta-catenin-BDNF axis, Al impairs hippocampal LTP, possibly through the GSK-3beta/beta-catenin signaling-mediated BDNF pathway.	Aluminum	63-65	catenin beta 1	Rattus norvegicus	39-51
33462795-12	2021	From the perspective of the identified beta-catenin-BDNF axis, Al impairs hippocampal LTP, possibly through the GSK-3beta/beta-catenin signaling-mediated BDNF pathway.	Aluminum	63-65	catenin beta 1	Rattus norvegicus	122-134
33121948-10	2021	Mechanistically, Wnt/beta-catenin pathway was activated in acetaldehyde-activated HSC-T6 cells and CD73 silencing or overexpression could regulate Wnt/beta-catenin signaling pathway.	Acetaldehyde	59-71	catenin beta 1	Rattus norvegicus	21-33
33106900-8	2021	In addition, BHB prevented the binding and co-localisation of HDAC3 to beta-catenin in HG-stimulated HCMECs.	3-Hydroxybutyric Acid	13-16	catenin beta 1	Rattus norvegicus	71-83
33106900-8	2021	In addition, BHB prevented the binding and co-localisation of HDAC3 to beta-catenin in HG-stimulated HCMECs.	hcmecs	101-107	catenin beta 1	Rattus norvegicus	71-83
33553429-0	2021	Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/beta-Catenin Signaling Pathway.	icariin	0-7	catenin beta 1	Rattus norvegicus	125-137
33553429-6	2021	Based on our previous research, we hypothesized that ICA promotes bone formation via the sclerostin/Wnt/beta-catenin signaling pathway.	icariin	53-56	catenin beta 1	Rattus norvegicus	104-116
33553429-10	2021	Mechanistically, ICA exerted these effects by activating the Wnt/beta-catenin pathway.	icariin	17-20	catenin beta 1	Rattus norvegicus	65-77
33584201-6	2020	The Wnt/beta-catenin pathway has been implicated in neural stem cell proliferation and synapse development, and Wnt/beta-catenin pathway inhibition effectively blocked the neurogenic effects of CIHH.	cihh	194-198	catenin beta 1	Rattus norvegicus	8-20
33584201-6	2020	The Wnt/beta-catenin pathway has been implicated in neural stem cell proliferation and synapse development, and Wnt/beta-catenin pathway inhibition effectively blocked the neurogenic effects of CIHH.	cihh	194-198	catenin beta 1	Rattus norvegicus	116-128
33584201-7	2020	Our findings indicate that CIHH rescues cognitive deficits in epileptic rats via Wnt/beta-catenin pathway activation.	cihh	27-31	catenin beta 1	Rattus norvegicus	85-97
33121948-10	2021	Mechanistically, Wnt/beta-catenin pathway was activated in acetaldehyde-activated HSC-T6 cells and CD73 silencing or overexpression could regulate Wnt/beta-catenin signaling pathway.	Acetaldehyde	59-71	catenin beta 1	Rattus norvegicus	151-163
33262822-11	2021	In addition, hypoxia induction inhibited the expression of LRH-1, cyclin D1 and beta-catenin, which was reversed by miR-219-5p inhibitor.	mir-219-5p	116-126	catenin beta 1	Rattus norvegicus	80-92
33262822-12	2021	However, LRH-1 downregulation reversed the miR-219-5p inhibitor enhanced cell viability, decreased cell apoptosis and increased expression of LRH-1, cyclin D1 and beta-catenin in hypoxia-treated cardiomyocytes.	mir-219-5p	43-53	catenin beta 1	Rattus norvegicus	163-175
33262822-13	2021	The present results demonstrated that downregulation of miR-219-5p promoted the expression of the LRH-1/Wnt/beta-catenin signaling pathway-associated components, reduced cardiomyocyte apoptosis and increased cell growth under hypoxic conditions.	mir-219-5p	56-66	catenin beta 1	Rattus norvegicus	108-120
33278748-9	2021	Importantly, these mentioned effects of AZ (60 mg/kg) on CIA rats could be reversed by the combined use of lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway.	Acetazolamide	40-42	catenin beta 1	Rattus norvegicus	152-164
33278748-9	2021	Importantly, these mentioned effects of AZ (60 mg/kg) on CIA rats could be reversed by the combined use of lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway.	Lithium Chloride	107-123	catenin beta 1	Rattus norvegicus	152-164
33278748-9	2021	Importantly, these mentioned effects of AZ (60 mg/kg) on CIA rats could be reversed by the combined use of lithium chloride (LiCl), an activator of Wnt/beta-catenin pathway.	Lithium Chloride	125-129	catenin beta 1	Rattus norvegicus	152-164
33278748-10	2021	In short, AZ exerted potent anti-arthritic effects on CIA rats by inducing synovial apoptosis and inhibiting Wnt/beta-catenin pathway.	Acetazolamide	10-12	catenin beta 1	Rattus norvegicus	113-125
33380723-7	2020	iPTH promoted osteoblastic differentiation and might further regulate the Wnt/beta-catenin pathway in a STAT3-dependent manner.	3,4-O-isopropylidene-3,3',4,5'-tetrahydroxystilbene	0-4	catenin beta 1	Rattus norvegicus	78-90
32985377-13	2021	CONCLUSION: Propofol ameliorates NP and neuroinflammation of rats by up-regulating PPAR gamma expression to block the Wnt/beta-catenin pathway.	Propofol	12-20	catenin beta 1	Rattus norvegicus	122-134
33530899-6	2021	RESULTS: Blocking beta-catenin with ICG001, a small molecule inhibitor of beta-catenin/TCF via binding to cAMP-response elementbinding protein, attenuated airway inflammation by increasing levels of anti-inflammation cytokines IL-10, IL-35 and decreasing levels of T helper (Th)2 cells and Th17 cytokine.	Cyclic AMP	106-110	catenin beta 1	Rattus norvegicus	18-30
33530899-6	2021	RESULTS: Blocking beta-catenin with ICG001, a small molecule inhibitor of beta-catenin/TCF via binding to cAMP-response elementbinding protein, attenuated airway inflammation by increasing levels of anti-inflammation cytokines IL-10, IL-35 and decreasing levels of T helper (Th)2 cells and Th17 cytokine.	Cyclic AMP	106-110	catenin beta 1	Rattus norvegicus	74-86
32985377-0	2021	Propofol ameliorates neuropathic pain and neuroinflammation through PPAR gamma up-regulation to block Wnt/beta-catenin pathway.	Propofol	0-8	catenin beta 1	Rattus norvegicus	106-118
33350543-16	2020	Circ-ITCH could protect myocardial cells from injuries caused by H2O2 by suppressing apoptosis while miR-17-5p played a reverse role, which could upregulate apoptosis and inhibit cell viability via Wnt/beta-catenin signalling pathway.	mir-17-5p	101-110	catenin beta 1	Rattus norvegicus	202-214
33350543-0	2020	Circular RNA ITCH mediates H2O2-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/beta-catenin signalling pathway.	Hydrogen Peroxide	27-31	catenin beta 1	Rattus norvegicus	97-109
32064936-10	2020	MEG3, Wnt/beta-catenin and PTEN/PI3K/AKT pathways joined in adjusting the activity of PA in H2O2-damaged PC12 cells.	Hydrogen Peroxide	92-96	catenin beta 1	Rattus norvegicus	10-22
33350543-0	2020	Circular RNA ITCH mediates H2O2-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/beta-catenin signalling pathway.	mir-17-5p	79-88	catenin beta 1	Rattus norvegicus	97-109
33350543-14	2020	Wnt3a, Wnt5a and beta-catenin in Wnt/beta-catenin signalling pathway were increased after H2O2 induction.	Hydrogen Peroxide	90-94	catenin beta 1	Rattus norvegicus	17-29
33350543-14	2020	Wnt3a, Wnt5a and beta-catenin in Wnt/beta-catenin signalling pathway were increased after H2O2 induction.	Hydrogen Peroxide	90-94	catenin beta 1	Rattus norvegicus	37-49
33171191-0	2020	Daphnetin ameliorates glucocorticoid-induced osteoporosis via activation of Wnt/GSK-3beta/beta-catenin signaling.	daphnetin	0-9	catenin beta 1	Rattus norvegicus	90-102
33171191-11	2020	Moreover, Daph activated the Wnt/GSK-3beta/beta-catenin signaling pathway.	daphnetin	10-14	catenin beta 1	Rattus norvegicus	43-55
33171191-14	2020	Collectively, these data demonstrated that Daph effectively ameliorates GIOP and the possible mechanism may be that Daph activated Wnt/GSK-3beta/beta-catenin signaling.	daphnetin	43-47	catenin beta 1	Rattus norvegicus	145-157
33171191-14	2020	Collectively, these data demonstrated that Daph effectively ameliorates GIOP and the possible mechanism may be that Daph activated Wnt/GSK-3beta/beta-catenin signaling.	daphnetin	116-120	catenin beta 1	Rattus norvegicus	145-157
33447176-10	2020	Conclusion: Genistein could effectively improve abnormal bone metabolism in STZ-induced diabetic rats; the underlying molecular mechanisms might be related to OPG/RANKL, PPAR-gamma, and beta-catenin/Runx-2 pathways.	Genistein	12-21	catenin beta 1	Rattus norvegicus	186-198
32024386-6	2020	The activation of PI3K/AKT/mTOR and Wnt/beta-catenin pathways was tested by western blot.Results: Dex attenuated H2O2-induced oxidative damage, including the decline of cell viability, the raise of apoptosis and the generation of ROS in PC12 cells by down-regulating miR-199a expression.	Dexmedetomidine	98-101	catenin beta 1	Rattus norvegicus	40-52
32024386-8	2020	In addition, Dex activated PI3K/AKT/mTOR and Wnt/beta-catenin pathways by declining miR-199a level.Conclusions: This article illustrated the protective effect of Dex on oxidative damage in PC12 cells.	Dexmedetomidine	13-16	catenin beta 1	Rattus norvegicus	49-61
33075003-10	2020	Furthermore, H2O2 significantly weakened the transduction of Wnt signaling, including the increases of GSK-3beta and TCF-1 expressions and the decrease of beta-catenin expression, while NISCH downregulation attenuated the effect of H2O2 on Wnt signaling.	Hydrogen Peroxide	13-17	catenin beta 1	Rattus norvegicus	155-167
32064936-5	2020	Western blot was conducted to determine Wnt/beta-catenin and PTEN/PI3K/AKT pathways.Results: H2O2 stimulation clearly triggered PC12 cell damage via prohibiting cell viability and accelerating apoptosis and autophagy.	Hydrogen Peroxide	93-97	catenin beta 1	Rattus norvegicus	44-56
32064936-9	2020	Beyond that, PA activated Wnt/beta-catenin and PTEN/PI3K/AKT via repression of MEG3 in H2O2-managed PC12 cells.Conclusions: The results disclosed the protective impacts of PA on PC12 cells to resist H2O2-provoked damage.	protocatechualdehyde	13-15	catenin beta 1	Rattus norvegicus	30-42
32024386-8	2020	In addition, Dex activated PI3K/AKT/mTOR and Wnt/beta-catenin pathways by declining miR-199a level.Conclusions: This article illustrated the protective effect of Dex on oxidative damage in PC12 cells.	Dexmedetomidine	162-165	catenin beta 1	Rattus norvegicus	49-61
33038376-0	2020	Oridonin promotes osteogenesis through Wnt/beta-catenin pathway and inhibits RANKL-induced osteoclastogenesis in vitro.	oridonin	0-8	catenin beta 1	Rattus norvegicus	43-55
32882667-13	2020	RESULTS: The group of niclosamide-and-CCl4-treated rats showed a significant decrease in total bilirubin, ALT and AST, beta-catenin, l-hydroxyproline, l-glutaminase activity, and gene expression of TGF-beta1 and Dvl2.	Niclosamide	22-33	catenin beta 1	Rattus norvegicus	119-131
32882667-15	2020	On the other hand, lithium chloride-and-CCl4-treated rats showed a significant increase in liver indices, TGF-beta1 expression, beta-catenin, l-hydroxyproline, and l-glutaminase activity with severe alpha-SMA reactivity and apoptosis in the liver tissue.	Lithium Chloride	19-35	catenin beta 1	Rattus norvegicus	128-140
32882667-16	2020	CONCLUSIONS: Niclosamide protected rats against liver fibrosis by inhibiting the Wnt/beta-catenin pathway and glutaminolysis.	Niclosamide	13-24	catenin beta 1	Rattus norvegicus	85-97
32064936-9	2020	Beyond that, PA activated Wnt/beta-catenin and PTEN/PI3K/AKT via repression of MEG3 in H2O2-managed PC12 cells.Conclusions: The results disclosed the protective impacts of PA on PC12 cells to resist H2O2-provoked damage.	protocatechualdehyde	172-174	catenin beta 1	Rattus norvegicus	30-42
32064936-10	2020	MEG3, Wnt/beta-catenin and PTEN/PI3K/AKT pathways joined in adjusting the activity of PA in H2O2-damaged PC12 cells.	protocatechualdehyde	86-88	catenin beta 1	Rattus norvegicus	10-22
33328006-16	2020	The USP7 specific inhibitor P5091 may accelerate the degradation of beta-catenin by enhancing its ubiquitination, reduce lung epithelial-mesenchymal transition, and thus exert a certain protective effect against hyperoxic lung injury.	P5091	28-33	catenin beta 1	Rattus norvegicus	68-80
33259862-0	2020	MiR-216b-5p attenuates chronic constriction injury-induced neuropathic pain in female rats by targeting MAL2 and inactivating Wnt/beta-catenin signaling pathway.	mir-216b-5p	0-11	catenin beta 1	Rattus norvegicus	130-142
32777532-5	2020	Next, by conducting a serial in vitro and vivo experiments, we found that miR-24-3p regulated the Wnt5a/beta-Catenin Signaling levels to promote neuropathic pain progression via targeting LPAR3 in CCI rats.	mir-24-3p	74-83	catenin beta 1	Rattus norvegicus	104-116
33259862-8	2020	MiR-216b-5p inactivated the Wnt/beta-catenin signaling pathway through downregulation of MAL2.	mir-216b-5p	0-11	catenin beta 1	Rattus norvegicus	32-44
33259862-10	2020	Finally, rescue assays demonstrated that the activation of Wnt/beta-catenin signaling pathway or MAL2 upregulation reversed the inhibitory influence of miR-216b-5p on neuropathic pain.	mir-216b-5p	152-163	catenin beta 1	Rattus norvegicus	63-75
33259862-11	2020	In conclusion, miR-216b-5p alleviated neuropathic pain in rats by targeting MAL2 to inactivate the Wnt/beta-catenin signaling pathway, which may provide novel insight for the therapy of neuropathic pain.	mir-216b-5p	15-26	catenin beta 1	Rattus norvegicus	103-115
32830537-4	2020	Treatment with DRI ameliorated proteinuria (20.33 +- 5.88 mg/day) and markedly reduced glomerular crescent formation (20.9 +- 2.6%), induction of macrophage infiltration, (P)RR, phospho-ERK1/2, Wnt4, and active beta-catenin.	4-O-METHYL-2,6-DIDEOXY-BETA-D-GLUCOSE	15-18	catenin beta 1	Rattus norvegicus	211-223
33294736-6	2021	RNA-sequencing illustrated that the Zn-0.8Sr alloy promoted osteogenesis by activating the wnt/beta-catenin, PI3K/Akt, and MAPK/Erk signaling pathways.	Zinc	36-38	catenin beta 1	Rattus norvegicus	95-107
33132177-0	2020	Therapeutic effect of metformin on inflammation and apoptosis after spinal cord injury in rats through the Wnt/beta-catenin signaling pathway.	Metformin	22-31	catenin beta 1	Rattus norvegicus	111-123
33132177-1	2020	OBJECTIVE: To verify the effect of metformin on spinal cord injury (SCI) through Wnt/beta-catenin signaling pathway.	Metformin	35-44	catenin beta 1	Rattus norvegicus	85-97
33132177-5	2020	Whether metformin could improve SCI through Wnt/beta-catenin signaling pathway remains unclear.	Metformin	8-17	catenin beta 1	Rattus norvegicus	48-60
33132177-6	2020	METHODS: Rats were divided into sham group, SCI group, SCI + metformin group, metformin + XAV939 group (XAV939 is an effective inhibitor of the Wnt/beta-catenin signaling pathway), and methylprednisolone group.	XAV939	104-110	catenin beta 1	Rattus norvegicus	148-160
33132177-9	2020	RESULTS: Metformin(50 mg/kg) promoted motor functional recovery in rats after SCI, increased the expressions of beta-catenin and brain derived neurotrophic factor (BDNF), inhibited neuron apoptosis and inflammatory response, and improved the recovery of pathological morphology at the injury site by activating the Wnt/beta-catenin signaling pathway.	Metformin	9-18	catenin beta 1	Rattus norvegicus	112-124
33132177-9	2020	RESULTS: Metformin(50 mg/kg) promoted motor functional recovery in rats after SCI, increased the expressions of beta-catenin and brain derived neurotrophic factor (BDNF), inhibited neuron apoptosis and inflammatory response, and improved the recovery of pathological morphology at the injury site by activating the Wnt/beta-catenin signaling pathway.	Metformin	9-18	catenin beta 1	Rattus norvegicus	319-331
33132177-10	2020	CONCLUSION: We found a possible mechanism that metformin could reduce inflammation and apoptosis, and promote functional recovery of SCI rats through activating Wnt/beta-catenin signaling pathway.	Metformin	47-56	catenin beta 1	Rattus norvegicus	165-177
33200535-0	2022	circ-AKT3 aggravates renal ischaemia-reperfusion injury via regulating miR-144-5p /Wnt/beta-catenin pathway and oxidative stress.	mir-144-5p	71-81	catenin beta 1	Rattus norvegicus	87-99
33159018-6	2020	Both phosphate and TGF-beta1 increased the protein level of beta-catenin, which was partially mitigated by LY364947.	Phosphates	5-14	catenin beta 1	Rattus norvegicus	60-72
33159018-6	2020	Both phosphate and TGF-beta1 increased the protein level of beta-catenin, which was partially mitigated by LY364947.	Ly-364947	107-115	catenin beta 1	Rattus norvegicus	60-72
32800810-0	2020	Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/beta-catenin pathway.	Amisulpride	0-11	catenin beta 1	Rattus norvegicus	115-127
32800810-4	2020	Hitherto, the direct effects of amisulpride on Wnt/beta-catenin signaling and microglial activity have not been thoroughly studied.	Amisulpride	32-43	catenin beta 1	Rattus norvegicus	51-63
32800810-5	2020	This study aimed at investigating the effects of chronic amisulpride treatment on Wnt/beta-catenin signaling and pro-inflammatory microglial activation and its role in alleviation of depressive-like behavior and cognitive deficits elicited by unpredictable chronic mild stress (UCMS).	Amisulpride	57-68	catenin beta 1	Rattus norvegicus	86-98
32800810-9	2020	Amisulpride improved UCMS-induced behavioral/cognitive deficits, ameliorated Wnt/beta-catenin signaling dysregulation and pro-inflammatory microglial activation.	Amisulpride	0-11	catenin beta 1	Rattus norvegicus	81-93
32800810-10	2020	This work highlights the antidepressant and pro-cognitive effects of amisulpride in UCMS-exposed rats that could be mediated by modulation of Wnt/beta-catenin pathway activity and amelioration of pro-inflammatory microglial activation in the prefrontal cortex.	Amisulpride	69-80	catenin beta 1	Rattus norvegicus	146-158
33116749-11	2020	As an activator of beta-catenin signaling, lithium chloride (an inhibitor of GSK-3beta) reversed the inhibitory effects of AQP1 siRNA on the cultured CIA FLS.	Lithium Chloride	43-59	catenin beta 1	Rattus norvegicus	19-31
33036206-11	2020	The protective effects of lipid emulsion and survival-related expression of genes such as Akt, GSK-3beta, Wnt1 and beta-catenin were reversed by the intra-peritoneal administration of XAV939 through the inhibition of the Wnt/beta-catenin signaling pathway.	XAV939	184-190	catenin beta 1	Rattus norvegicus	115-127
33036206-11	2020	The protective effects of lipid emulsion and survival-related expression of genes such as Akt, GSK-3beta, Wnt1 and beta-catenin were reversed by the intra-peritoneal administration of XAV939 through the inhibition of the Wnt/beta-catenin signaling pathway.	XAV939	184-190	catenin beta 1	Rattus norvegicus	225-237
33167932-0	2020	Emodin protected against retinal ischemia insulted neurons through the downregulation of protein overexpression of beta-catenin and vascular endothelium factor.	Emodin	0-6	catenin beta 1	Rattus norvegicus	115-127
33167932-14	2020	CONCLUSIONS: The present results suggest that emodin might protect against retinal ischemia insulted neurons such as RGCs by significantly downregulating the upregulation of beta-catenin/VEGF protein that occurs during ischemia.	Emodin	46-52	catenin beta 1	Rattus norvegicus	174-186
32761926-0	2020	XQ-1H attenuates ischemic injury in PC12 cells via Wnt/beta-catenin signaling via inhibition of apoptosis and promotion of proliferation.	xq-1h	0-5	catenin beta 1	Rattus norvegicus	55-67
32768578-11	2020	Besides, XAV939 (an inhibitor of the Wnt/beta-catenin pathway) proved the connection of JLX001 and Wnt/beta-catenin pathway.	XAV939	9-15	catenin beta 1	Rattus norvegicus	41-53
32768578-11	2020	Besides, XAV939 (an inhibitor of the Wnt/beta-catenin pathway) proved the connection of JLX001 and Wnt/beta-catenin pathway.	XAV939	9-15	catenin beta 1	Rattus norvegicus	103-115
32737772-6	2020	Interestingly, we also found that [6]-gingerol, an anti-OA drug, could upregulate the protein level of Usp49 and suppress the Wnt/beta-catenin signaling cascade in primary rat chondrocytes.	gingerol	34-46	catenin beta 1	Rattus norvegicus	130-142
32830537-8	2020	Interestingly, (P)RR or Wnt4-specific siRNA treatment or the beta-catenin antagonist XAV939 inhibited the elevation of MCP-1 expression, whereas DRI did not.	XAV939	85-91	catenin beta 1	Rattus norvegicus	61-73
32502517-0	2020	The bone marrow-derived mesenchymal stem cells (BMSCs) alleviate diabetic peripheral neuropathy induced by STZ via activating GSK-3beta/beta-catenin signaling pathway.	Streptozocin	107-110	catenin beta 1	Rattus norvegicus	136-148
32791354-11	2020	CONCLUSIONS: Our data demonstrated that LMHF mechanical vibration promotes BMSCs chondrogenic differentiation and implies beta-catenin signal acts as an essential mediator in the mechano-biochemical transduction and subsequent transcriptional regulation in the process of chondrogenesis.	lmhf	40-44	catenin beta 1	Rattus norvegicus	122-134
32793347-0	2020	Lipolysis by downregulating miR-92a activates the Wnt/beta-catenin signaling pathway in hypoxic rats.	mir-92a	28-35	catenin beta 1	Rattus norvegicus	54-66
32472701-1	2020	This study evaluated if the nephroprotective effect of Salidroside in type 1 diabetes mellitus (T1DM) involves modulation of Wnt/beta-catenin signaling pathways.	rhodioloside	55-66	catenin beta 1	Rattus norvegicus	129-141
32472701-6	2020	Concomitantly, Salidorside significantly increased the levels of p-beta-catenin (Ser33/37 /Thr41 ) and suppressed protein levels of Axin-2, fibronectin, and, mRNA and protein levels of collagen IIIa, the main targets of beta-catenin.	salidorside	15-26	catenin beta 1	Rattus norvegicus	67-79
32472701-6	2020	Concomitantly, Salidorside significantly increased the levels of p-beta-catenin (Ser33/37 /Thr41 ) and suppressed protein levels of Axin-2, fibronectin, and, mRNA and protein levels of collagen IIIa, the main targets of beta-catenin.	salidorside	15-26	catenin beta 1	Rattus norvegicus	220-232
32472701-8	2020	In conclusion, Salidroside protected against the kidney of rats from T1DM-induced injury and fibrosis by activating GS3Kbeta-induced inhibition of Wnt1/Wnt3a beta-catenin.	rhodioloside	15-26	catenin beta 1	Rattus norvegicus	158-170
32806417-0	2020	Polystyrene microplastics cause cardiac fibrosis by activating Wnt/beta-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats.	Polystyrenes	0-11	catenin beta 1	Rattus norvegicus	67-79
32502517-9	2020	CONCLUSIONS: We verified that BMSCs alleviate diabetic peripheral neuropathy of rats induced by STZ via activating GSK-3beta/beta-catenin signaling pathway, which implied a novel biomarker for diabetic peripheral neuropathy treatment.	Streptozocin	96-99	catenin beta 1	Rattus norvegicus	125-137
33029500-8	2020	For comparison, alendronate combined with DFO further improved the bone volume, trabecular number, trabecular separation, and trabecular thickness with lower ratio of osteocyte lacunae and OC number, higher expression of OCN and VEGF and upregulated signal factors of HIF-1alpha and beta-catenin, and decreased RANKL and NFATc1.	Alendronate	16-27	catenin beta 1	Rattus norvegicus	283-295
33085064-12	2020	Western blot analysis revealed that the transfection of miR-124-3p mimics could further reverse the upregulated p-beta-catenin and GSK-3beta levels and the downregulated c-Myc and CyclinD1 levels induced by high glucose.	Glucose	212-219	catenin beta 1	Rattus norvegicus	114-126
33085064-13	2020	IF results revealed that BMSCs treated CHIR99021 under high glucose showed the reduced GSK-3beta and increased beta-catenin and CyclinD1 expression levels.	Glucose	60-67	catenin beta 1	Rattus norvegicus	111-123
32783850-3	2020	Here, we evaluated the role and regulation of Wnt/beta-catenin pathway in Sb-mediated neurotoxicity.	Antimony	74-76	catenin beta 1	Rattus norvegicus	50-62
32783850-4	2020	Under Sb treatment, beta-catenin was dramatically downregulated in vivo and in vitro.	Antimony	6-8	catenin beta 1	Rattus norvegicus	20-32
32977843-7	2020	Knocking down miR-138-5p in MSCs increased the expression of protein tyrosine kinase 2 (PTK2, encoding FAK) to suppress autophagy, while downregulating miR-141-3p enhanced the level of beta-catenin to promote cell proliferation.	mir-138-5p	14-24	catenin beta 1	Rattus norvegicus	185-197
32977843-7	2020	Knocking down miR-138-5p in MSCs increased the expression of protein tyrosine kinase 2 (PTK2, encoding FAK) to suppress autophagy, while downregulating miR-141-3p enhanced the level of beta-catenin to promote cell proliferation.	mir-141-3p	152-162	catenin beta 1	Rattus norvegicus	185-197
32562163-0	2020	HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3beta/beta-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	0-5	catenin beta 1	Rattus norvegicus	58-70
32562163-2	2020	Recently, HLY78 has been shown to inhibit apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/beta-catenin pathway.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	10-15	catenin beta 1	Rattus norvegicus	148-160
32562163-4	2020	The results demonstrated that HLY78 attenuated neuronal apoptosis and the neurological deficits after SAH through the activation of low-density lipoprotein receptor-related protein 6 (LRP6), which subsequently increased the level of phosphorylated glycogen synthesis kinase 3 beta (p-GSK3beta) (Ser9), beta-catenin, and Bcl-2, accompanied by a decrease of p-beta-catenin, Bax, and cleaved caspase 3.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	30-35	catenin beta 1	Rattus norvegicus	302-314
32562163-4	2020	The results demonstrated that HLY78 attenuated neuronal apoptosis and the neurological deficits after SAH through the activation of low-density lipoprotein receptor-related protein 6 (LRP6), which subsequently increased the level of phosphorylated glycogen synthesis kinase 3 beta (p-GSK3beta) (Ser9), beta-catenin, and Bcl-2, accompanied by a decrease of p-beta-catenin, Bax, and cleaved caspase 3.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	30-35	catenin beta 1	Rattus norvegicus	358-370
32562163-6	2020	In conclusion, HLY78 attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3beta/beta-catenin signaling pathway after SAH in rats.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	15-20	catenin beta 1	Rattus norvegicus	112-124
32783850-8	2020	For upstream pathway analysis, we found Sb treatment decreased protein kinase B (Akt) phosphorylation, and Akt activator protected PC12 cells from GSK-3beta activation and subsequent beta-catenin suppression.	Antimony	40-42	catenin beta 1	Rattus norvegicus	183-195
32783850-9	2020	In summary, our data provided a novel molecular mechanism of Sb-associated neurotoxicity, namely that Sb induces Wnt/beta-catenin pathway suppression through Akt inhibition, thus resulted in neuronal apoptosis.	Antimony	61-63	catenin beta 1	Rattus norvegicus	117-129
32783850-9	2020	In summary, our data provided a novel molecular mechanism of Sb-associated neurotoxicity, namely that Sb induces Wnt/beta-catenin pathway suppression through Akt inhibition, thus resulted in neuronal apoptosis.	Antimony	102-104	catenin beta 1	Rattus norvegicus	117-129
33040788-0	2020	Effects of latanoprost on the expression of TGF-beta1 and Wnt / beta-catenin signaling pathway in the choroid of form-deprivation myopia rats.	Latanoprost	11-22	catenin beta 1	Rattus norvegicus	64-76
33040788-1	2020	In this study, we investigated the effect of latanoprost on the expression of TGF- beta1 and Wnt / beta - Catenin signal pathway in the choroid of form-deprivation myopia model rats.	Latanoprost	45-56	catenin beta 1	Rattus norvegicus	99-113
33029500-8	2020	For comparison, alendronate combined with DFO further improved the bone volume, trabecular number, trabecular separation, and trabecular thickness with lower ratio of osteocyte lacunae and OC number, higher expression of OCN and VEGF and upregulated signal factors of HIF-1alpha and beta-catenin, and decreased RANKL and NFATc1.	Deferoxamine	42-45	catenin beta 1	Rattus norvegicus	283-295
33162794-0	2020	Dexamethasone inhibits BMP7-induced osteogenic differentiation in rat dental follicle cells via the PI3K/AKT/GSK-3beta/beta-catenin pathway.	Dexamethasone	0-13	catenin beta 1	Rattus norvegicus	119-131
32889066-0	2021	MiR-216a-5p alleviates chronic constriction injury-induced neuropathic pain in rats by targeting KDM3A and inactivating Wnt/beta-catenin signaling pathway.	mir-216a-5p	0-11	catenin beta 1	Rattus norvegicus	124-136
33162794-4	2020	This study aimed to explore the effects of high concentrations of DEX on osteogenic signaling pathways, including BMP/Smad and Wnt/beta-catenin pathways, in rat dental follicle cells (rDFCs) and to elucidate the possible mechanisms.	Dexamethasone	66-69	catenin beta 1	Rattus norvegicus	131-143
33162794-7	2020	DEX also reduced the mRNA and protein levels of beta-catenin by enhancing the expression of GSK-3beta.	Dexamethasone	0-3	catenin beta 1	Rattus norvegicus	48-60
33162794-10	2020	This study suggests that high concentrations of DEX may inhibit the expression of beta-catenin via the PI3K/AKT/GSK-3beta pathway in a manner mediated by BMP7.	Dexamethasone	48-51	catenin beta 1	Rattus norvegicus	82-94
32930541-0	2020	beta-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet.	Fructose	109-117	catenin beta 1	Rattus norvegicus	0-12
32930541-2	2020	Intake of high fructose leads to non-alcoholic fatty liver disease by stimulating lipid synthesis, and beta-catenin is the key molecule for realizing GLP-1 function in extrahepatic tissues; with the discovery of GLP-1 receptor in liver, we speculate that beta-catenin might mediate GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose.	Fructose	355-363	catenin beta 1	Rattus norvegicus	103-115
32652472-1	2020	CGK012 is a newly synthesized pyranocoumarin substance suppressing the activation and transcription of beta-catenin related to Wnt3a-CM.	Pyranocoumarins	30-44	catenin beta 1	Rattus norvegicus	103-115
32930541-4	2020	After the intervention of exenatide, the hepatic steatosis induced by high fructose was improved, the nuclear translocation and expression of beta-catenin were facilitated, and the mRNA and protein expression of the upstream regulator SREBP-1 and the downstream key enzymes ACC, FAS and SCD-1 of de novo lipogenesis were down-regulated.	Exenatide	26-35	catenin beta 1	Rattus norvegicus	142-154
32930541-5	2020	GLP-1 receptor agonist may ameliorate hepatic steatosis induced by high fructose by beta-catenin regulating de novo lipogenesis pathway.	Fructose	72-80	catenin beta 1	Rattus norvegicus	84-96
32238888-3	2020	We previously have illuminated the protective role of canonical Wnt/beta-catenin signaling in Dox-induced cardiotoxicity.	Doxorubicin	94-97	catenin beta 1	Rattus norvegicus	68-80
32238888-9	2020	After intraperitoneal injection of a cumulative dose of 15 mg/kg Dox, rats displayed significant cardiac dysfunction; their heart showed inhibited Wnt/beta-catenin signaling and activated Wnt/PCP-JNK signaling.	Doxorubicin	65-68	catenin beta 1	Rattus norvegicus	151-163
32889066-9	2021	To sum up, our study confirmed that miR-216a-5p alleviated neuropathic pain in rats by targeting KDM3A and inactivating the Wnt/beta-catenin signaling pathway, which may open a new and useful way for treatment of neuropathic pain.	mir-216a-5p	36-47	catenin beta 1	Rattus norvegicus	128-140
32715762-3	2020	The purpose of the present study was to investigate whether the Wnt/beta-catenin signaling in MCs contributes to GLP-1RA-induced inhibition of ECM accumulation and mitigation of glomerular injury in diabetic nephropathy.	CHEMBL2402005	117-120	catenin beta 1	Rattus norvegicus	68-80
32565130-0	2020	HLY78 protects blood-brain barrier integrity through Wnt/beta-catenin signaling pathway following subarachnoid hemorrhage in rats.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	0-5	catenin beta 1	Rattus norvegicus	57-69
32787367-15	2020	Furthermore, GDD rectified the expression of Wnt/beta-catenin signal pathway-related proteins in both livers of the copper-loaded and copper-stimulated BRL-3A cell lines.	Guanosine Diphosphate Mannose	13-16	catenin beta 1	Rattus norvegicus	49-61
32787367-15	2020	Furthermore, GDD rectified the expression of Wnt/beta-catenin signal pathway-related proteins in both livers of the copper-loaded and copper-stimulated BRL-3A cell lines.	Copper	116-122	catenin beta 1	Rattus norvegicus	49-61
32787367-15	2020	Furthermore, GDD rectified the expression of Wnt/beta-catenin signal pathway-related proteins in both livers of the copper-loaded and copper-stimulated BRL-3A cell lines.	Copper	134-140	catenin beta 1	Rattus norvegicus	49-61
32565130-2	2020	HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/beta-catenin signaling in vitro.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	0-5	catenin beta 1	Rattus norvegicus	78-90
32565130-2	2020	HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/beta-catenin signaling in vitro.	lycorine	9-17	catenin beta 1	Rattus norvegicus	78-90
32565130-8	2020	Moreover, HLY78 markedly increased the beta-catenin expression followed with the up-regulation of Occludin, ZO-1, and Claudin-5 after SAH, which was reversed by LRP6 siRNA.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	10-15	catenin beta 1	Rattus norvegicus	39-51
32565130-9	2020	In conclusion, HLY78 could preserve BBB integrity, possibly through the Wnt/beta-catenin signaling pathway.	4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine	15-20	catenin beta 1	Rattus norvegicus	76-88
32780664-0	2020	Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3beta/beta-catenin signaling.	Doxorubicin	27-38	catenin beta 1	Rattus norvegicus	133-145
32983019-1	2020	Clostridioides difficile toxin A (TcdA) has been shown to inhibit cellular Wnt signaling, the major driving force behind the proliferation of epithelial cells in colonic crypts, likely through the inhibition of beta-catenin nuclear translocation.	tcda	34-38	catenin beta 1	Rattus norvegicus	211-223
32983019-8	2020	In vivo, TcdA decreased beta-catenin, cyclin D1, and cMYC expression and inhibited the translocation of beta-catenin into the nucleus in the ileum epithelial cells.	tcda	9-13	catenin beta 1	Rattus norvegicus	24-36
32983019-8	2020	In vivo, TcdA decreased beta-catenin, cyclin D1, and cMYC expression and inhibited the translocation of beta-catenin into the nucleus in the ileum epithelial cells.	tcda	9-13	catenin beta 1	Rattus norvegicus	104-116
32983019-10	2020	In vitro, constitutively active Rac1 prevented Wnt signaling inhibition by enabling the beta-catenin nuclear translocation that had been blocked by TcdA.	tcda	148-152	catenin beta 1	Rattus norvegicus	88-100
32983019-11	2020	Our results show that TcdA inhibits Wnt/beta-catenin pathway in vivo and demonstrate that this inhibition is likely caused by a Rac1-mediated mechanism.	tcda	22-26	catenin beta 1	Rattus norvegicus	40-52
32681548-4	2020	We showed that combination of exercise training and Quercetin supplementation resulted in the significant improvement in depressive-live behaviors and decrease in tumor incidence through modulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	52-61	catenin beta 1	Rattus norvegicus	216-228
32681548-12	2020	In addition, DMH administration increased inflammatory cytokines in the serum cortical and tumor tissues, as well as decreased the expression levels of brain-derived neurotrophic factor, tyrosine kinase beta receptor and beta-catenin in the cortex.	1,2-Dimethylhydrazine	13-16	catenin beta 1	Rattus norvegicus	221-233
32681548-14	2020	Taken together, our results showed that quercetin and exercise training exerts potent anti-tumor and anti-depressive effects through suppressing inflammation and upregulation of BDNF/ TrKbeta /beta-catenin axis in the prefrontal cortex.	Quercetin	40-49	catenin beta 1	Rattus norvegicus	193-205
32863225-0	2020	Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium.	Asbestos	0-8	catenin beta 1	Rattus norvegicus	106-118
32863225-0	2020	Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium.	ammonium ferrous sulfate	19-25	catenin beta 1	Rattus norvegicus	106-118
32863225-5	2020	DNA damage in mesothelial cells, as assessed by 8-hydroxy-2"-deoxyguanosine and gamma-H2AX, increased after crocidolite exposure during regeneration accompanied by beta-catenin activation.	Asbestos, Crocidolite	108-119	catenin beta 1	Rattus norvegicus	164-176
32863225-6	2020	Conversely, beta-catenin overexpression in mesothelial cells induced higher intracellular catalytic Fe(II) with increased G2/M cell-cycle fraction, when p16INK4A genomic loci localized more peripherally in the nucleus.	ammonium ferrous sulfate	100-106	catenin beta 1	Rattus norvegicus	12-24
32863225-7	2020	Mesothelial cells after challenge of H2O2 under beta-catenin overexpression presented low p16INK4A expression with a high incidence of deletion in p16INK4A locus.	Hydrogen Peroxide	37-41	catenin beta 1	Rattus norvegicus	48-60
33312213-8	2020	The data showed that wnt and beta-catenin gene expression were elevated in grape sap treated animals versus bleomycin group (P < 0.01 and 0.001, respectively).	Bleomycin	108-117	catenin beta 1	Rattus norvegicus	29-41
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	54-70	catenin beta 1	Rattus norvegicus	32-44
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	54-70	catenin beta 1	Rattus norvegicus	115-127
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	54-70	catenin beta 1	Rattus norvegicus	115-127
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	72-76	catenin beta 1	Rattus norvegicus	32-44
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	72-76	catenin beta 1	Rattus norvegicus	115-127
32952947-8	2020	When given the activator of Wnt/beta-catenin pathway (lithium chloride, LiCl) to BMSCs transducted with TGF-beta1, beta-catenin was increased, while phosphorylated beta-catenin was decreased.	Lithium Chloride	72-76	catenin beta 1	Rattus norvegicus	115-127
32162076-6	2020	Furthermore, the liver contents of growth factors as well as beta-catenin and cyclin D1protein expressions were also enhanced by celecoxib.	Celecoxib	129-138	catenin beta 1	Rattus norvegicus	61-73
32780664-6	2020	In addition, doxorubicin inhibited AKT/GSK3beta/beta-catenin signaling, whereas YXC increased the expression of phosphorylated AKT and GSK3beta, and beta-catenin in doxorubicin-treated H9c2 cells.	Doxorubicin	13-24	catenin beta 1	Rattus norvegicus	48-60
32780664-6	2020	In addition, doxorubicin inhibited AKT/GSK3beta/beta-catenin signaling, whereas YXC increased the expression of phosphorylated AKT and GSK3beta, and beta-catenin in doxorubicin-treated H9c2 cells.	Doxorubicin	165-176	catenin beta 1	Rattus norvegicus	149-161
32240652-0	2020	Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: Insight on hedgehog /Gli and Wnt/ beta-catenin signaling crosstalk.	pyrvinium	0-17	catenin beta 1	Rattus norvegicus	94-106
32958128-11	2020	Expression levels of beta-catenin, VEGF, AngII protein were obviously up-regulated in Naoluoxintong high- and middle-dose groups.	naoluoxintong	86-99	catenin beta 1	Rattus norvegicus	21-33
32774700-11	2020	Furthermore, we demonstrated that SAA could activate Wnt/beta-catenin pathway and play the neuroprotective role by regulating miR-499a/DDK1.	salvianolic acid A	34-37	catenin beta 1	Rattus norvegicus	57-69
32656187-5	2020	Resulting cellular profiles illustrate the effect of pericellular oxygen concentration and consumption rates on hepatic functionality in terms of zone-specific metabolism and beta-catenin signaling.	Oxygen	66-72	catenin beta 1	Rattus norvegicus	175-187
32120262-10	2020	Accompanied by changes in Leydig cell proliferation and differentiation, PFOS also significantly reduced phosphorylation of glycogen synthase kinase-3beta while increased phosphorylation of beta-catenin.	perfluorooctane sulfonic acid	73-77	catenin beta 1	Rattus norvegicus	190-202
32555173-10	2020	BBR induced the expression of beta-catenin and enhanced beta-catenin entering into the nucleus, to up-regulate more runt-related nuclear factor 2 downstream.	Berberine	0-3	catenin beta 1	Rattus norvegicus	30-42
32555173-10	2020	BBR induced the expression of beta-catenin and enhanced beta-catenin entering into the nucleus, to up-regulate more runt-related nuclear factor 2 downstream.	Berberine	0-3	catenin beta 1	Rattus norvegicus	56-68
32299547-1	2020	YU16-S3 accelerates cutaneous wound healing through Wnt/beta-catenin pathway.	yu16-s3	0-7	catenin beta 1	Rattus norvegicus	56-68
32299547-10	2020	In vivo experiments in rats showed the re-epithelialization of injured tissue with increased expression of HB-EGF, FGF, E-cadherin and beta-catenin in EPS-S3 treatment.	eps-s3	151-157	catenin beta 1	Rattus norvegicus	135-147
32299547-11	2020	The results indicate that EPS-S3 modulates healing process through Wnt/beta-catenin pathway due to its unique characteristics.	exophthalmos producing substance	26-29	catenin beta 1	Rattus norvegicus	71-83
32413244-0	2020	The opposite functions of miR-24 in the osteogenesis and adipogenesis of adipose-derived mesenchymal stem cells are mediated by the HOXB7/beta-catenin complex.	mir-24	26-32	catenin beta 1	Rattus norvegicus	138-150
32655669-0	2020	Keratinocyte Growth Factor-2 Reduces Inflammatory Response to Acute Lung Injury Induced by Oleic Acid in Rats by Regulating Key Proteins of the Wnt/beta-Catenin Signaling Pathway.	Oleic Acid	91-101	catenin beta 1	Rattus norvegicus	148-160
32655669-20	2020	KGF-2 may reduce the inflammatory response in ALI induced by oleic acid by regulating key proteins in the Wnt/beta-catenin signaling pathway.	Oleic Acid	61-71	catenin beta 1	Rattus norvegicus	110-122
32474680-9	2021	CONCLUSION: Exendin-4 inhibits the remodeling in the remote myocardium of rats following acute MI by attenuating beta-catenin activation and activating beta-arrestin-2, PP2A, and GSK3beta.	Exenatide	12-21	catenin beta 1	Rattus norvegicus	113-125
32323840-8	2020	In addition, ES significantly increased the proliferation activity of DRG cells, increased the number of cells in the G2 phase, decreased the apoptotic rate and activated the Wnt/beta-catenin pathway, ultimately reversing the injury caused by CMS.	N-Carbamoylsarcosine	243-246	catenin beta 1	Rattus norvegicus	179-191
32323840-9	2020	Following inhibition of the Wnt/beta-catenin signaling pathway using XAV939, the effects of ES were weakened.	XAV939	69-75	catenin beta 1	Rattus norvegicus	32-44
32078732-6	2020	Together, these findings suggest that, adolescent social isolation by altering the Wnt/beta-catenin pathway in the developing PFC might increase the cocaine responses during adulthood, introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.	Cocaine	149-156	catenin beta 1	Rattus norvegicus	87-99
32547170-12	2020	In phase 2 study, both NR2B subunit antagonist Ro25-6981 and iwp-2 decreased the amount of activated NR2B, enhanced p-GSK-3beta (Ser9), reduced beta-catenin, c-fos and NF-kappaB in the lumbar spinal cord (p < 0.001).	Ro 25-6981	47-56	catenin beta 1	Rattus norvegicus	144-156
32420586-4	2020	After treatment with rosiglitazone, the protein expression level of PPARgamma was significantly up-regulated, the phosphorylation level of PTEN/beta-catenin pathway was decreased, the PTEN/beta-catenin pathway was inhibited, the lung injury, inflammation and apoptosis were reduced.	Rosiglitazone	21-34	catenin beta 1	Rattus norvegicus	144-156
32420586-4	2020	After treatment with rosiglitazone, the protein expression level of PPARgamma was significantly up-regulated, the phosphorylation level of PTEN/beta-catenin pathway was decreased, the PTEN/beta-catenin pathway was inhibited, the lung injury, inflammation and apoptosis were reduced.	Rosiglitazone	21-34	catenin beta 1	Rattus norvegicus	189-201
32420586-6	2020	Besides, bpV inhibited PTEN/beta-catenin pathway, and relieved the lung tissue injury.	bromopyruvate	9-12	catenin beta 1	Rattus norvegicus	28-40
32596380-0	2020	Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating Wnt/Beta-Catenin Signaling.	Iron	0-4	catenin beta 1	Rattus norvegicus	98-110
32596380-0	2020	Iron-Chelating Agent Can Maintain Bone Homeostasis Disrupted by Iron Overload by Upregulating Wnt/Beta-Catenin Signaling.	Iron	64-68	catenin beta 1	Rattus norvegicus	98-110
32596380-2	2020	In this study, we explored the activities of Wnt/beta-catenin signaling in bone tissues with iron accumulation.	Iron	93-97	catenin beta 1	Rattus norvegicus	49-61
32596380-11	2020	Conclusion: The osteoporosis could be caused by iron overload, which reduced the bone mineral density by disrupting the homeostasis of bone formation and absorption and attenuating the Wnt/beta-catenin signaling in bone tissues.	Iron	48-52	catenin beta 1	Rattus norvegicus	189-201
32547719-7	2020	In vitro experiments demonstrated that ABA treatment inhibited the Wnt/beta-catenin and mitochondrial-associated caspase pathways.	alisol B 23-acetate	39-42	catenin beta 1	Rattus norvegicus	71-83
32547170-10	2020	Results: Remifentanil infusion could induce overexpression of beta-catenin and wnt3a in rats.	Remifentanil	9-21	catenin beta 1	Rattus norvegicus	62-74
32547170-14	2020	Conclusion: Remifentanil exposure could induce overexpression of wnt3a and enhance the production of beta-catenin in the spinal dorsal horn.	Remifentanil	12-24	catenin beta 1	Rattus norvegicus	101-113
32147507-0	2020	Berberine alleviates pulmonary hypertension through Trx1 and beta-catenin signaling pathways in pulmonary artery smooth muscle cells.	Berberine	0-9	catenin beta 1	Rattus norvegicus	61-73
32205185-9	2020	In vitro, too high and too low of an RA intervention resulted in decreased proliferation, while an appropriate RA concentration (1-5 micromol/L) significantly promoted proliferation, S phase cells and high beta-catenin pathway expression.	Tretinoin	111-113	catenin beta 1	Rattus norvegicus	206-218
32544068-0	2020	Effect of kirenol on the interaction between the WNT/beta-Catenin and RUNX2/TCF/LEF1 pathways in fracture healing in vivo.	kirenol	10-17	catenin beta 1	Rattus norvegicus	53-65
32544068-1	2020	OBJECTIVE: This study aimed to determine the effects of a natural diterpenoid, kirenol, on fracture healing in vivo in an experimental rat model of femur fracture and investigate its potential mechanism of action via the Wnt/beta-catenin pathway.	kirenol	79-86	catenin beta 1	Rattus norvegicus	225-237
32544068-12	2020	CONCLUSION: Kirenol may improve fracture healing in a dose-dependent manner with the early activation of the Wnt/beta-catenin pathway and the activation of the Runx-2 pathway.	kirenol	12-19	catenin beta 1	Rattus norvegicus	113-125
31960520-0	2020	Neuroprotective effects of isoquercitrin in diabetic neuropathy via Wnt/beta-catenin signaling pathway inhibition.	isoquercitrin	27-40	catenin beta 1	Rattus norvegicus	72-84
31960520-2	2020	A growing body of evidence have depicted that high glucose levels can induce activation of the Wnt/beta-catenin pathway, however there are no studies targeting this pathway in DN.	Glucose	51-58	catenin beta 1	Rattus norvegicus	99-111
31960520-3	2020	The intent of the present study was to investigate the effects of isoquercitrin (ISQ), a Wnt/beta-catenin signaling pathway inhibitor, in diabetic neuropathy.	isoquercitrin	66-79	catenin beta 1	Rattus norvegicus	93-105
31960520-3	2020	The intent of the present study was to investigate the effects of isoquercitrin (ISQ), a Wnt/beta-catenin signaling pathway inhibitor, in diabetic neuropathy.	isoquercitrin	81-84	catenin beta 1	Rattus norvegicus	93-105
31960520-11	2020	Moreover, ISQ also downregulated the expression of Wnt/beta-catenin pathway proteins significantly in diabetic rats as compared to vehicle-treated diabetic rats.	isoquercitrin	10-13	catenin beta 1	Rattus norvegicus	55-67
31960520-12	2020	Results of the present study suggest the neuroprotective potential of ISQ in the treatment of DN via inhibition of Wnt/beta-catenin signaling pathway.	isoquercitrin	70-73	catenin beta 1	Rattus norvegicus	119-131
32354894-9	2020	Phosphorylation of beta-catenin was enhanced by continuous exposure to TG compared with intermittent exposure.	Thioguanine	71-73	catenin beta 1	Rattus norvegicus	19-31
32151688-0	2020	Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3beta and Wnt/beta-catenin signaling pathways.	naringin	47-55	catenin beta 1	Rattus norvegicus	136-148
32151688-15	2020	Moreover, naringin activated the neurodevelopmental wnt/beta-catenin signaling pathway evidenced by increasing pGSK-3beta and reducing pbeta-catenin protein expression.	pgsk-3beta	111-121	catenin beta 1	Rattus norvegicus	56-68
32205185-0	2020	Vitamin A regulates neural stem cell proliferation in rats after hypoxic-ischemic brain damage via RARalpha-mediated modulation of the beta-catenin pathway.	Vitamin A	0-9	catenin beta 1	Rattus norvegicus	135-147
32205185-8	2020	The mRNA and protein expression of RARalpha, AKT, GSK-3beta, beta-catenin and Cyclin D1 were significantly lower in the VAD group than in the VAN group.	vad	120-123	catenin beta 1	Rattus norvegicus	61-73
32070878-11	2020	Dex protects H9C2 cells against HR injury through miR-208b-3p/Med13/Wnt/beta-catenin signaling pathway axis.	Dexmedetomidine	0-3	catenin beta 1	Rattus norvegicus	72-84
32068571-0	2020	Sevoflurane sedation attenuates early cerebral oedema formation through stabilisation of the adherens junction protein beta catenin in a model of subarachnoid haemorrhage: A randomised rat study.	sevoflurane	0-11	catenin beta 1	Rattus norvegicus	119-131
32068571-15	2020	Decreased cytosolic fraction of beta-catenin in propofol-SAH animals (59 +- 15%) was found to reach values of sham animals (100%) in the presence of sevoflurane in SAH animals (89 +- 21%; P = 0.04).	sevoflurane	149-160	catenin beta 1	Rattus norvegicus	32-44
32323740-6	2020	XAV939 (an inhibitor of the Wnt/beta-catenin pathway) was used to confirm the effects of the Wnt/beta-catenin signaling pathway on exercise-mediated neurogenesis and myelin repair.	XAV939	0-6	catenin beta 1	Rattus norvegicus	32-44
32323740-13	2020	In addition, XAV939 inhibited treadmill exercise-induced neurogenesis and myelin repair, which was consistent with the downregulation of Wnt3a, nucleus beta-catenin, BDNF and MBP expression, and the deterioration of neurological function.	XAV939	13-19	catenin beta 1	Rattus norvegicus	152-164
32147507-7	2020	Furthermore, berberine had an antiproliferative effect on hypoxia-induced HPASMC proliferation in a manner likely mediated by inhibiting Trx1 and its target gene beta-catenin expression.	Berberine	13-22	catenin beta 1	Rattus norvegicus	162-174
31809235-0	2020	Melatonin protects bone against cadmium -induced toxicity via activation of Wnt/beta-catenin signaling pathway.	Melatonin	0-9	catenin beta 1	Rattus norvegicus	80-92
32684804-10	2020	The expression of beta-catenin also increased, following the pattern of 4-HNE.	4-hydroxy-2-nonenal	72-77	catenin beta 1	Rattus norvegicus	18-30
32684804-12	2020	Conclusion: This work suggests that lipid peroxidation product, 4-HNE, activated the WNT/beta-catenin pathway, leading to the development of reactive astrocyte and microglia activation in hydrocephalus.	4-hydroxy-2-nonenal	64-69	catenin beta 1	Rattus norvegicus	89-101
31809235-0	2020	Melatonin protects bone against cadmium -induced toxicity via activation of Wnt/beta-catenin signaling pathway.	Cadmium	32-39	catenin beta 1	Rattus norvegicus	80-92
31809235-7	2020	Since mechanistically Cd toxicity reduced the Kinase activity of GSK3beta and protein levels of Wnt3a and beta-catenin, we observed that MLT administration significantly ameliorated the toxic effects induced by the metal.	Cadmium	22-24	catenin beta 1	Rattus norvegicus	106-118
31809235-7	2020	Since mechanistically Cd toxicity reduced the Kinase activity of GSK3beta and protein levels of Wnt3a and beta-catenin, we observed that MLT administration significantly ameliorated the toxic effects induced by the metal.	Melatonin	137-140	catenin beta 1	Rattus norvegicus	106-118
31809235-8	2020	Our findings provide clues about a potential protective effect of MLT against Cd-induced bone metabolism destruction and that the protection was partially mediated via the Wnt/beta-catenin signaling pathway.	Melatonin	66-69	catenin beta 1	Rattus norvegicus	176-188
31809235-8	2020	Our findings provide clues about a potential protective effect of MLT against Cd-induced bone metabolism destruction and that the protection was partially mediated via the Wnt/beta-catenin signaling pathway.	Cadmium	78-80	catenin beta 1	Rattus norvegicus	176-188
32420385-8	2020	Collectively, our study indicated the role of POSTN in the osteogenesis and stemness of OVX-BMSCs and proves that 17beta-E2 reduces osteoporosis and promotes osteogenesis through the POSTN-Wnt/beta-catenin pathway.	17beta-e2	114-123	catenin beta 1	Rattus norvegicus	193-205
32352404-10	2020	The OV-induced overexpression of beta-catenin and ER were also ameliorated by 3PFBPA.	3pfbpa	78-84	catenin beta 1	Rattus norvegicus	33-45
32318748-9	2021	In our previous experiment, we found that Wnt/beta-catenin signaling pathway, whose functions are opposite to Notch signaling pathway, can be further activated by exogenous thyroxine in rats with sTBI.	Thyroxine	173-182	catenin beta 1	Rattus norvegicus	46-58
32318748-22	2021	After TBI, exogenous thyroxine can activate Notch and Wnt/beta-catenin, and have a synergistic effect on the repair of central nervous system, which may be related to the up-regulation of Notch and Wnt/beta-catenin signaling pathway mRNA expression and the increase of BDNF and NGF, and resist apoptosis in the brain of sTBI rats.	Thyroxine	21-30	catenin beta 1	Rattus norvegicus	58-70
32318748-22	2021	After TBI, exogenous thyroxine can activate Notch and Wnt/beta-catenin, and have a synergistic effect on the repair of central nervous system, which may be related to the up-regulation of Notch and Wnt/beta-catenin signaling pathway mRNA expression and the increase of BDNF and NGF, and resist apoptosis in the brain of sTBI rats.	Thyroxine	21-30	catenin beta 1	Rattus norvegicus	202-214
32068029-0	2020	Berberine encapsulated PEG-coated liposomes attenuate Wnt1/beta-catenin signaling in rheumatoid arthritis via miR-23a activation.	Berberine	0-9	catenin beta 1	Rattus norvegicus	59-71
32359380-0	2020	Tormentic acid confers protection against oxidative stress injury in rats with Parkinson"s disease by targeting the Wnt/beta-catenin signaling pathway.	euscaphic acid	0-14	catenin beta 1	Rattus norvegicus	120-132
32359380-14	2020	The results of qRT-PCR and Western blotting showed that treatment with TMA significantly activated Wnt/beta-catenin signaling pathway (p < 0.05).	euscaphic acid	71-74	catenin beta 1	Rattus norvegicus	103-115
32359380-16	2020	These results suggest that TMA confers protection against OS-induced injury in rats with PD by targeting the Wnt/beta-catenin signaling pathway.	euscaphic acid	27-30	catenin beta 1	Rattus norvegicus	113-125
31958453-0	2020	Protective effects of Erdosteine on interleukin-1beta-stimulated inflammation via inhibiting the activation of MAPK, NF-kappaB, and Wnt/beta-catenin signaling pathways in rat osteoarthritis.	erdosteine	22-32	catenin beta 1	Rattus norvegicus	136-148
31958453-9	2020	Furthermore, our study revealed that ER could inhibit the activations of IL-1beta-induced MAPK and Wnt/beta-catenin.	erdosteine	37-39	catenin beta 1	Rattus norvegicus	103-115
32280833-7	2020	Sr-CPS extracts were found to promote osteogenesis by upregulating Wnt/beta-catenin signal pathways and inhibit osteoclastogenesis through downregulating NF-kappaB signal pathway.	sr-cps	0-6	catenin beta 1	Rattus norvegicus	71-83
32068029-7	2020	PEG-BBR treatment markedly inhibited the expression of LRP5 protein on par with the DKK-1 (LRP5/Wnt signaling inhibitor) and suppressed the transcriptional activation of beta-catenin inside the cells.	peg-bbr	0-7	catenin beta 1	Rattus norvegicus	170-182
32068029-0	2020	Berberine encapsulated PEG-coated liposomes attenuate Wnt1/beta-catenin signaling in rheumatoid arthritis via miR-23a activation.	Polyethylene Glycols	23-26	catenin beta 1	Rattus norvegicus	59-71
32068029-5	2020	Moreover, PEG-BBR treatment in FLS cells attenuated the gene and protein expression levels of FZD4, LRP5, beta-catenin, and Dvl-1 through the induction of CYLD.	peg-bbr	10-17	catenin beta 1	Rattus norvegicus	106-118
31951975-4	2020	RESULTS: In vivo, G-Rg1 treatment could improve the structural disorganization, low water content, NPCs number and aggrecan and collagenII expression in IVD and down-regulate the expression of beta-catenin.	g-rg1	18-23	catenin beta 1	Rattus norvegicus	193-205
32258025-10	2020	Our work demonstrates that ALDH1A2 expression can be directly repressed by the Wnt/beta-catenin signaling in fetal kidney cells, suggesting that Wnt/beta-catenin may play a role in maintaining the expression pattern of ALDH1A2 in the fetal kidney, thus controlling the availability and localization of retinoic acid and regulating aspects of kidney development.	Tretinoin	302-315	catenin beta 1	Rattus norvegicus	83-95
32258025-10	2020	Our work demonstrates that ALDH1A2 expression can be directly repressed by the Wnt/beta-catenin signaling in fetal kidney cells, suggesting that Wnt/beta-catenin may play a role in maintaining the expression pattern of ALDH1A2 in the fetal kidney, thus controlling the availability and localization of retinoic acid and regulating aspects of kidney development.	Tretinoin	302-315	catenin beta 1	Rattus norvegicus	149-161
31951975-5	2020	In vitro NPCs, G-Rg1 treatment could improve the low cell proliferation, high apoptosis rate and low expression of aggrecan and collagenII in degenerative NPCs in a dose-dependent manner.G-Rg1 treatment could down-regulate the expression of proteins related to beta-catenin signal and LiCl could reverse the increase of cell proliferation and ECM synthesis, decrease of apoptosis of degenerative NPCs induced by G-Rg1.	g-rg1	15-20	catenin beta 1	Rattus norvegicus	261-273
31951975-5	2020	In vitro NPCs, G-Rg1 treatment could improve the low cell proliferation, high apoptosis rate and low expression of aggrecan and collagenII in degenerative NPCs in a dose-dependent manner.G-Rg1 treatment could down-regulate the expression of proteins related to beta-catenin signal and LiCl could reverse the increase of cell proliferation and ECM synthesis, decrease of apoptosis of degenerative NPCs induced by G-Rg1.	g-rg1	187-192	catenin beta 1	Rattus norvegicus	261-273
31951975-5	2020	In vitro NPCs, G-Rg1 treatment could improve the low cell proliferation, high apoptosis rate and low expression of aggrecan and collagenII in degenerative NPCs in a dose-dependent manner.G-Rg1 treatment could down-regulate the expression of proteins related to beta-catenin signal and LiCl could reverse the increase of cell proliferation and ECM synthesis, decrease of apoptosis of degenerative NPCs induced by G-Rg1.	g-rg1	187-192	catenin beta 1	Rattus norvegicus	261-273
31951975-6	2020	CONCLUSION: G-Rg1 could promote ECM synthesis of degenerative NPCs and inhibiting its apoptosis, improve the IVDD via inhibiting the Wnt/beta-catenin pathway.	g-rg1	12-17	catenin beta 1	Rattus norvegicus	137-149
32475100-12	2020	And Wnt-1 and beta-catenin were higher in the Daidzin group than those in the Control group.	daidzin	46-53	catenin beta 1	Rattus norvegicus	14-26
32475100-14	2020	Caveolin-1, Wnt-1 and beta-catenin in lung tissues also markedly declined in the Daidzin group compared with those in the COPD group.	daidzin	81-88	catenin beta 1	Rattus norvegicus	22-34
32074731-1	2020	Objective: To investigate the change and association of glioma-associated oncogene homolog 1 (Gli1) and beta-catenin on bone formation in rats with chronic fluorosis which were inhibited by cyclopamine (Cycl).	cyclopamine	190-201	catenin beta 1	Rattus norvegicus	104-116
31852203-0	2020	Pharmacological stimulation of Wnt/beta-catenin signaling pathway attenuates the course of thioacetamide-induced acute liver failure.	Thioacetamide	91-104	catenin beta 1	Rattus norvegicus	35-47
31852203-3	2020	Given the importance in the liver biology of Wnt/beta-catenin signaling pathway, we hypothesized that its stimulation could enhance hepatocyte regeneration and attenuate the course of thioacetamide (TAA)-induced ALF in Lewis rats.	Thioacetamide	184-197	catenin beta 1	Rattus norvegicus	49-61
31852203-3	2020	Given the importance in the liver biology of Wnt/beta-catenin signaling pathway, we hypothesized that its stimulation could enhance hepatocyte regeneration and attenuate the course of thioacetamide (TAA)-induced ALF in Lewis rats.	Thioacetamide	199-202	catenin beta 1	Rattus norvegicus	49-61
32054968-0	2020	Author Correction: Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis.	Mianserin	19-28	catenin beta 1	Rattus norvegicus	78-90
32103895-0	2020	Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/beta-Catenin Signaling Pathway in STZ-Induced Diabetic Rats.	Streptozocin	98-101	catenin beta 1	Rattus norvegicus	64-76
32040269-0	2020	Inhibition of Rac1 activity by NSC23766 prevents cartilage endplate degeneration via Wnt/beta-catenin pathway.	NSC 23766	31-39	catenin beta 1	Rattus norvegicus	89-101
32040269-7	2020	Moreover, we also found that NSC23766 could suppress the activation of Wnt/beta-catenin pathway, suggesting that the beneficial effects of Rac1 inhibition in EPCs are mediated through the Wnt/beta-catenin signalling.	NSC 23766	29-37	catenin beta 1	Rattus norvegicus	75-87
32040269-7	2020	Moreover, we also found that NSC23766 could suppress the activation of Wnt/beta-catenin pathway, suggesting that the beneficial effects of Rac1 inhibition in EPCs are mediated through the Wnt/beta-catenin signalling.	NSC 23766	29-37	catenin beta 1	Rattus norvegicus	192-204
32088641-0	2020	MiR-145-5p mitigates dysregulated Wnt1/beta-catenin signaling pathway in rheumatoid arthritis.	mir-145-5p	0-10	catenin beta 1	Rattus norvegicus	39-51
32088641-4	2020	This study explores the underlying mechanism of miR-145-5p towards the Wnt1/beta-catenin pathway.	mir-145-5p	48-58	catenin beta 1	Rattus norvegicus	76-88
32088641-10	2020	Hence, we suggest that miR-145-5p regulates the survival/proliferation of FLS cells in RA disease condition through attenuation of Wnt1/beta-catenin signaling.	mir-145-5p	23-33	catenin beta 1	Rattus norvegicus	136-148
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	83-87	catenin beta 1	Rattus norvegicus	27-39
32074731-12	2020	The expression of Gli1 and beta-catenin mRNA and protein was higher in the F and F+Cycl groups than controls, but lower in the F+Cycl group than in the F group.	cyclopamine	129-133	catenin beta 1	Rattus norvegicus	27-39
31714664-8	2020	Further, we found that administration of XHA suppressed the wnt/beta-catenin signaling together with modulation of apoptotic proteins Bax, Bcl-2, and caspase 3.	2-[(2~{r},3~{s},4~{r},5~{r})-5-(Hydroxymethyl)-3,4-Bis(Oxidanyl)-1-[3-[3-(Trifluoromethyl)phenyl]propyl]pyrrolidin-2-Yl]-~{n}-Methyl-Ethanamide	41-44	catenin beta 1	Rattus norvegicus	64-76
31918279-8	2020	Licl was used as Wnt/beta-catenin signaling pathway activator in chondrocytes to determine the molecular mechanisms.	Lithium Chloride	0-4	catenin beta 1	Rattus norvegicus	21-33
31918279-9	2020	Activation of Wnt signaling pathway by Licl up-regulated beta-catenin, CyclinD1, Axin2, Caspase-3, Caspase-9, MMP-3, MMP-13 and IL-1beta.	Lithium Chloride	39-43	catenin beta 1	Rattus norvegicus	57-69
32010242-0	2020	Salvianolic acid B activates Wnt/beta-catenin signaling following spinal cord injury.	salvianolic acid B	0-18	catenin beta 1	Rattus norvegicus	33-45
32010242-6	2020	In addition, Sal B treatment enhanced the expression of beta-catenin.	salvianolic acid B	13-18	catenin beta 1	Rattus norvegicus	56-68
32010242-9	2020	In summary, the present study produced novel data demonstrating the neuroprotective effect of Sal B on SCI with the mechanism likely primarily mediated via the Wnt/beta-catenin signaling pathway.	salvianolic acid B	94-99	catenin beta 1	Rattus norvegicus	164-176
31835090-11	2020	At last, TLX worked in H2O2-injury via Smad and Wnt/beta-catenin pathways.	Hydrogen Peroxide	23-27	catenin beta 1	Rattus norvegicus	52-64
31883297-5	2020	In this study, we used rat bone marrow-derived mesenchymal stem cells and found that imperatorin can activate RUNX2, COL1A1 and osteocalcin by promoting the Ser9 phosphorylation of GSK3beta and entry of beta-catenin into the nucleus.	imperatorin	85-96	catenin beta 1	Rattus norvegicus	203-215
31883297-7	2020	We used ipatasertib, a pan-AKT inhibitor, to inhibit the osteogenic effect of imperatorin, and found that imperatorin promotes osteogenesis via AKT/GSK3beta/beta-catenin pathway.	imperatorin	106-117	catenin beta 1	Rattus norvegicus	157-169
32166663-0	2020	Inhibition of NF-kappaB and Wnt/beta-catenin/GSK3beta Signaling Pathways Ameliorates Cardiomyocyte Hypertrophy and Fibrosis in Streptozotocin (STZ)-induced Type 1 Diabetic Rats.	Streptozocin	127-141	catenin beta 1	Rattus norvegicus	32-44
32166663-0	2020	Inhibition of NF-kappaB and Wnt/beta-catenin/GSK3beta Signaling Pathways Ameliorates Cardiomyocyte Hypertrophy and Fibrosis in Streptozotocin (STZ)-induced Type 1 Diabetic Rats.	Streptozocin	143-146	catenin beta 1	Rattus norvegicus	32-44
32166663-6	2020	In addition, we found that inhibiting NF-kappaB and Wnt/beta-catenin/GSK3beta pathways could regulate glucose and lipid metabolism.	Glucose	102-109	catenin beta 1	Rattus norvegicus	56-68
32082150-0	2019	Propoxyphene Mediates Oxyhemoglobin-Induced Injury in Rat Cortical Neurons Through Up-Regulation of Active-beta-Catenin.	Dextropropoxyphene	0-12	catenin beta 1	Rattus norvegicus	107-119
31770525-4	2020	Our results demonstrate that LTB4 dose- and time-dependently induced proliferation of primary cultured rat PASMCs, this was accompanied with the activation of phosphatidylinositol-3-kinase/Akt (PI3K/Akt) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways, and consequent inactivation of glycogen synthase kinase-3beta (GSK-3beta), up-regulation of beta-catenin and induction of cyclin D1 expression.	Leukotriene B4	29-33	catenin beta 1	Rattus norvegicus	371-383
32082395-0	2020	Ginsenoside Rg1 Alleviates Podocyte EMT Passage by Regulating AKT/GSK3 beta/beta-Catenin Pathway by Restoring Autophagic Activity.	Ginsenosides	0-11	catenin beta 1	Rattus norvegicus	76-88
32082395-12	2020	Conclusion: Ginsenoside Rg1 alleviated podocyte EMT by enhancing AKT/GSK3beta/beta-catenin pathway-mediated autophagy, indicating its therapeutic potential for DN and other glomerular diseases.beta/beta/.	Ginsenosides	12-23	catenin beta 1	Rattus norvegicus	78-90
31770525-0	2020	Leukotriene B4 induces proliferation of rat pulmonary arterial smooth muscle cells via modulating GSK-3beta/beta-catenin pathway.	Leukotriene B4	0-14	catenin beta 1	Rattus norvegicus	108-120
31770525-5	2020	The presence of PI3K inhibitor (LY294002) or MEK inhibitor (U0126) or prior silencing of beta-catenin with siRNA suppressed LTB4-induced cyclin D1 up-regulation and PASMCs proliferation.	Leukotriene B4	124-128	catenin beta 1	Rattus norvegicus	89-101
31770525-7	2020	Taken together, our study indicates that activation of PI3K/Akt and ERK1/2 pathways mediate LTB4-induced PASMCs proliferation by modulating GSK-3beta/beta-catenin/cyclin D1 axis and suggests that targeting this pathway might have potential value in alleviating vascular remodeling and benefit PAH.	Leukotriene B4	92-96	catenin beta 1	Rattus norvegicus	150-162
32399022-0	2020	Crocin Alleviates Pain Hyperalgesia in AIA Rats by Inhibiting the Spinal Wnt5a/beta-Catenin Signaling Pathway and Glial Activation.	crocin	0-6	catenin beta 1	Rattus norvegicus	79-91
31860056-11	2020	In ex vivo experiments, high phosphorus and LPS increased nuclear beta-catenin and p65-NFkappaB and decreased Klotho.	Phosphorus	29-39	catenin beta 1	Rattus norvegicus	66-78
32399022-4	2020	Emerging evidence indicates that crocin may inhibit the metastasis of lung and liver cancer cells from the breast by inhibiting Wnt/beta-catenin and the Wnt signaling pathway is closely related to RA.	crocin	33-39	catenin beta 1	Rattus norvegicus	132-144
32399022-11	2020	This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/beta-catenin pathway, elucidating the mechanism by which crocin relieves neuropathic pain and provides a new way of thinking for the treatment of AIA pain.	crocin	25-31	catenin beta 1	Rattus norvegicus	148-160
32399022-11	2020	This research shows that crocin may alleviate neuropathic pain in AIA rats by inhibiting the expression of pain-related molecules through the Wnt5a/beta-catenin pathway, elucidating the mechanism by which crocin relieves neuropathic pain and provides a new way of thinking for the treatment of AIA pain.	crocin	205-211	catenin beta 1	Rattus norvegicus	148-160
32138537-0	2020	(-)-Epigallocatechin Gallate Promotes MicroRNA 145 Expression against Myocardial Hypoxic Injury through Dab2/Wnt3a/beta-catenin.	epigallocatechin gallate	0-28	catenin beta 1	Rattus norvegicus	115-127
32138537-8	2020	The western blot and real-time PCR data revealed that hypoxic stress with 2.5% O2 suppressed the expression of miR-145 and Wnt3a/beta-catenin in cultured rat cardiomyocytes but augmented Dab2.	Oxygen	79-81	catenin beta 1	Rattus norvegicus	129-141
32138537-9	2020	Treatment with EGCG attenuated Dab2 expression, but increased Wnt3a and beta-catenin in hypoxic cultured cardiomyocytes.	epigallocatechin gallate	15-19	catenin beta 1	Rattus norvegicus	72-84
32138537-11	2020	This study demonstrated that EGCG increased miR-145, Wnt3a, and beta-catenin expression but attenuated Dab2 expression.	epigallocatechin gallate	29-33	catenin beta 1	Rattus norvegicus	64-76
33480237-0	2020	Triptolide mediates Wnt/beta-catenin signalling pathway to reduce cerebral ischemia-reperfusion injury in rats.	triptolide	0-10	catenin beta 1	Rattus norvegicus	24-36
31786764-0	2020	Ketamine exerts neurotoxic effects on the offspring of pregnant rats via the Wnt/beta-catenin pathway.	Ketamine	0-8	catenin beta 1	Rattus norvegicus	81-93
31786764-12	2020	In conclusion, maternal anesthesia with ketamine in the second trimester of pregnancy can lead to cognitive memory impairment and neurotoxicity in the hippocampus of offspring through Wnt/ beta-catenin signaling pathway.	Ketamine	40-48	catenin beta 1	Rattus norvegicus	189-201
32525771-0	2020	Icariin accelerate fracture healing via activation of WNT1/beta-catenin osteogenic signaling pathway.	icariin	0-7	catenin beta 1	Rattus norvegicus	59-71
31627035-8	2020	These results suggest that TBT could reduce BMD via inhibition of the Wnt/beta-catenin pathway and skew the adipo-osteogenic balance in the BM of rats.	tributyltin	27-30	catenin beta 1	Rattus norvegicus	74-86
31443121-8	2020	In addition, the regulation of osteogenic differentiation in BMSCs treated with MGO might be involved with the Wnt/beta-catenin and BMP signaling pathways.	mgo	80-83	catenin beta 1	Rattus norvegicus	115-127
31443121-8	2020	In addition, the regulation of osteogenic differentiation in BMSCs treated with MGO might be involved with the Wnt/beta-catenin and BMP signaling pathways.	wnt	111-114	catenin beta 1	Rattus norvegicus	115-127
31585350-0	2020	Osteogenesis enhancement of silk fibroin/ alpha-TCP cement by N-acetyl cysteine through Wnt/beta-catenin signaling pathway in vivo and vitro.	N-acetyl-tranylcypromine	42-51	catenin beta 1	Rattus norvegicus	92-104
31883812-9	2020	However, Ucf-101 down-regulated the activation of GSK3beta and activated the Wnt/beta-catenin pathway that was caused by 6-OHDA.	Oxidopamine	121-127	catenin beta 1	Rattus norvegicus	81-93
31585350-0	2020	Osteogenesis enhancement of silk fibroin/ alpha-TCP cement by N-acetyl cysteine through Wnt/beta-catenin signaling pathway in vivo and vitro.	Acetylcysteine	62-79	catenin beta 1	Rattus norvegicus	92-104
31585350-5	2020	We propose that NAC functioning as osteogenic factor by activating the Wnt/beta-catenin signaling pathway may be the possible mechanism of up-regulation of osteogenic genes.	N-acetylcysteine lysinate	16-19	catenin beta 1	Rattus norvegicus	75-87
31867790-6	2020	Treatment with lithium chloride ameliorated sevoflurane-induced cognitive disorder in rats by inhibiting the GSK-3beta/beta-catenin signaling pathway.	Lithium Chloride	15-31	catenin beta 1	Rattus norvegicus	119-131
31995798-11	2020	RESULT: SP decreased AQP1 and beta-catenin expressions in PAH rat model induced successfully by MCT.	Spironolactone	8-10	catenin beta 1	Rattus norvegicus	30-42
31995798-13	2020	AQP1 downregulation decreased beta-catenin expression, and SP lowered AQP1 and beta-catenin expressions elevated by ALDO in PASMCs.	Spironolactone	59-61	catenin beta 1	Rattus norvegicus	79-91
31995798-14	2020	SP offset ALDO"s effect on the upregulation of cell viability as well as AQP1 and beta-catenin expressions in PASMCs.	Spironolactone	0-2	catenin beta 1	Rattus norvegicus	82-94
31995798-17	2020	However, SP could be considered an effective drug regulating PASMCs proliferation through modulating AQP1 and beta-catenin expressions in PAH.	Spironolactone	9-11	catenin beta 1	Rattus norvegicus	110-122
31867790-6	2020	Treatment with lithium chloride ameliorated sevoflurane-induced cognitive disorder in rats by inhibiting the GSK-3beta/beta-catenin signaling pathway.	sevoflurane	44-55	catenin beta 1	Rattus norvegicus	119-131
31885611-0	2019	Effects of Ginsenoside Rg1 Regulating Wnt/beta-Catenin Signaling on Neural Stem Cells to Delay Brain Senescence.	ginsenoside Rg1	11-26	catenin beta 1	Rattus norvegicus	42-54
31712059-11	2019	Isoquercitrin also attenuated the increased HIF-1alpha expression while increased that of the VEGF and beta-catenin.	isoquercitrin	0-13	catenin beta 1	Rattus norvegicus	103-115
31826587-7	2019	The level of beta-catenin was detected by using serum-free culture and chloral hydrate to intervene chondrocytes in CRI group.	Chloral Hydrate	71-86	catenin beta 1	Rattus norvegicus	13-25
31826587-11	2019	The level of beta-catenin was significantly changed after intervention by using serum-free culture, chloral hydrate to alter the primary cilia expression rate (serum-free culture group: 0.61+-0.23, control: 0.39+-0.24, chloral hydrate group: 0.15+-0.11, F=6.476, P=0.012).	Chloral Hydrate	100-115	catenin beta 1	Rattus norvegicus	13-25
31826587-11	2019	The level of beta-catenin was significantly changed after intervention by using serum-free culture, chloral hydrate to alter the primary cilia expression rate (serum-free culture group: 0.61+-0.23, control: 0.39+-0.24, chloral hydrate group: 0.15+-0.11, F=6.476, P=0.012).	Chloral Hydrate	219-234	catenin beta 1	Rattus norvegicus	13-25
31885611-10	2019	Ginsenoside Rg1 promotes proliferation of neural stem cells and inhibits Wnt/beta-catenin pathway activation.	ginsenoside Rg1	0-15	catenin beta 1	Rattus norvegicus	77-89
31588805-8	2019	Furthermore, miR-24 inhibitor declined LBPs-induced change in Wnt/beta-catenin and JAK1/STAT3 pathways in OGD-injuried cells.	mir-24	13-19	catenin beta 1	Rattus norvegicus	66-78
31885611-12	2019	LiCl can activate the Wnt/beta-catenin signaling pathway of NSCs, and ginsenoside Rg1 can antagonize the senescence of NSCs caused by activation of the Wnt/beta-catenin signaling pathway and delay brain aging.	Lithium Chloride	0-4	catenin beta 1	Rattus norvegicus	26-38
31885611-12	2019	LiCl can activate the Wnt/beta-catenin signaling pathway of NSCs, and ginsenoside Rg1 can antagonize the senescence of NSCs caused by activation of the Wnt/beta-catenin signaling pathway and delay brain aging.	ginsenoside Rg1	70-85	catenin beta 1	Rattus norvegicus	156-168
31322008-14	2019	Attenuation in the phosphorylation level of PI3K, AKT and beta-catenin by OGD was reversed by bilobalide, whereas there were opposite results after transfected with miR-27a inhibitor.	bilobalide	94-104	catenin beta 1	Rattus norvegicus	58-70
31322008-15	2019	Conclusion: Bilobalide relieved OGD-caused H9c2 cell damage, raising cell activity and attenuating apoptosis via upregulating miR-27a and activating of PI3K/AKT and Wnt/beta-catenin signal pathway.	bilobalide	12-22	catenin beta 1	Rattus norvegicus	169-181
31322008-19	2019	Bilobalide actuates PI3K/AKT and Wnt/beta-catenin pathways.	bilobalide	0-10	catenin beta 1	Rattus norvegicus	37-49
31770017-0	2019	IM-12 activates the Wnt-beta-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke.	IM-12	0-5	catenin beta 1	Rattus norvegicus	24-36
31770017-9	2019	These results suggest that IM-12 reduces rtPA-induced HT and attenuates BBB disruption, possibly through activation of the Wnt-beta-catenin signaling pathway, and provides a potential therapeutic strategy for preventing tPA-induced HT after AIS.	IM-12	27-32	catenin beta 1	Rattus norvegicus	127-139
31845225-0	2019	Hydrogen Sulfide Attenuates High Glucose-induced Myocardial Injury in Rat Cardiomyocytes by Suppressing Wnt/beta-catenin Pathway.	Hydrogen Sulfide	0-16	catenin beta 1	Rattus norvegicus	108-120
31845225-7	2019	Meanwhile, the relationship between the CSE/H2S system and Wnt/beta-catenin pathway was analyzed and discussed in the high glucose-induced cardiomyocytes.	Glucose	123-130	catenin beta 1	Rattus norvegicus	63-75
31561068-0	2019	Guhong Injection promotes fracture healing by activating Wnt/beta-catenin signaling pathway in vivo and in vitro.	guhong	0-6	catenin beta 1	Rattus norvegicus	61-73
31561068-10	2019	All results demonstrate that GHI accelerates the proliferation of OBs and shortens the recovery time of bone structure, and the Wnt/beta-catenin signaling pathway is involved in the regulation process.	ghi	29-32	catenin beta 1	Rattus norvegicus	132-144
31454852-6	2019	The anti-fibrotic effects of resveratrol correlated with decreased proliferation of TECs in the interstitium and tubules, resulting in suppressed activity of the proliferation-related signalling pathways, including that of the MAPK, PI3K/Akt, Wnt/beta-catenin, and JAK2/STAT3 pathways.	Resveratrol	29-40	catenin beta 1	Rattus norvegicus	247-259
31845225-0	2019	Hydrogen Sulfide Attenuates High Glucose-induced Myocardial Injury in Rat Cardiomyocytes by Suppressing Wnt/beta-catenin Pathway.	Glucose	33-40	catenin beta 1	Rattus norvegicus	108-120
31845225-9	2019	Moreover, H2S could attenuate the Wnt/beta-catenin signalling pathway and up-regulate the expression of haem oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) in the diabetic myocardium cells.	hydrogen sulfite	10-13	catenin beta 1	Rattus norvegicus	38-50
31845225-10	2019	Together, these results demonstrated that H2S could attenuate high glucose-induced myocardial injury in rat cardiomyocytes by suppressing Wnt/beta-catenin pathway.	hydrogen sulfite	42-45	catenin beta 1	Rattus norvegicus	142-154
31845225-10	2019	Together, these results demonstrated that H2S could attenuate high glucose-induced myocardial injury in rat cardiomyocytes by suppressing Wnt/beta-catenin pathway.	Glucose	67-74	catenin beta 1	Rattus norvegicus	142-154
31845225-7	2019	Meanwhile, the relationship between the CSE/H2S system and Wnt/beta-catenin pathway was analyzed and discussed in the high glucose-induced cardiomyocytes.	hydrogen sulfite	44-47	catenin beta 1	Rattus norvegicus	63-75
31586636-0	2019	Pharmacological interventions targeting Wnt/beta-catenin signaling pathway attenuate paclitaxel-induced peripheral neuropathy.	Paclitaxel	85-95	catenin beta 1	Rattus norvegicus	44-56
31539560-0	2019	Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington"s disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/beta-catenin signalling pathways.	lercanidipine	0-13	catenin beta 1	Rattus norvegicus	172-184
31162548-11	2019	A glycogen synthase kinase-3 inhibitor, SB 216763, promoted cell proliferation by upregulation of total/cytoplasmic/nuclear beta-catenin and reversed tumor suppression of miR-137 mimics.	SB 216763	40-49	catenin beta 1	Rattus norvegicus	124-136
31671239-0	2019	Duck Egg White-Derived Peptide VSEE (Val-Ser-Glu-Glu) Regulates Bone and Lipid Metabolisms by Wnt/beta-Catenin Signaling Pathway and Intestinal Microbiota.	Valine	37-40	catenin beta 1	Rattus norvegicus	98-110
31671239-0	2019	Duck Egg White-Derived Peptide VSEE (Val-Ser-Glu-Glu) Regulates Bone and Lipid Metabolisms by Wnt/beta-Catenin Signaling Pathway and Intestinal Microbiota.	Serine	41-44	catenin beta 1	Rattus norvegicus	98-110
31671239-0	2019	Duck Egg White-Derived Peptide VSEE (Val-Ser-Glu-Glu) Regulates Bone and Lipid Metabolisms by Wnt/beta-Catenin Signaling Pathway and Intestinal Microbiota.	Glutamic Acid	45-48	catenin beta 1	Rattus norvegicus	98-110
31671239-0	2019	Duck Egg White-Derived Peptide VSEE (Val-Ser-Glu-Glu) Regulates Bone and Lipid Metabolisms by Wnt/beta-Catenin Signaling Pathway and Intestinal Microbiota.	Glutamic Acid	49-52	catenin beta 1	Rattus norvegicus	98-110
32029028-0	2019	[Diammonium glycyrrhizinate promotes the regeneration and repair of central nervous system in rats with severe traumatic brain injury by Wnt/beta-catenin signaling pathway].	Glycyrrhizic Acid	1-27	catenin beta 1	Rattus norvegicus	141-153
32029028-1	2019	OBJECTIVE: To observe the effects of diammonium glycyrrhizinate (DG) on nerve regeneration repair in rats with severe traumatic brain injury (STBI) from the perspective of Wnt/beta-catenin signaling pathway.	Glycyrrhizic Acid	37-68	catenin beta 1	Rattus norvegicus	176-188
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P &lt; 0.05].	Gangliosides	176-178	catenin beta 1	Rattus norvegicus	34-46
31799688-0	2019	Rosuvastatin promotes osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis by the Wnt/beta-catenin signal.	Rosuvastatin Calcium	0-12	catenin beta 1	Rattus norvegicus	119-131
31602218-8	2019	Blocking the p38 MAPK signaling pathway with a specific inhibitor SB203580 also downregulated the expressions of beta-catenin, cyclin D1 and c-Myc in vitro.	SB 203580	66-74	catenin beta 1	Rattus norvegicus	113-125
31799638-1	2019	OBJECTIVE: The aim of this study was to explore the influence of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) on fracture healing by activating the Wnt/beta-catenin signaling pathway.	Dinoprostone	90-106	catenin beta 1	Rattus norvegicus	156-168
31799688-1	2019	OBJECTIVE: The aim of this study was to explore the promoting effect of rosuvastatin on the osteogenic differentiation of mesenchymal stem cells in the rat model of osteoporosis through the Wnt/beta-catenin signal.	Rosuvastatin Calcium	72-84	catenin beta 1	Rattus norvegicus	194-206
31127951-13	2019	Moreover, the Biodentine -treated defects demonstrated beta-catenin expression in the pulp tissue adjacent to the newly formed reparative dentine, which was not observed with the other materials.	tricalcium silicate	14-24	catenin beta 1	Rattus norvegicus	55-67
31127951-15	2019	The favourable outcome after direct pulp capping with Biodentine  involved Wnt/beta-catenin signalling.	tricalcium silicate	54-64	catenin beta 1	Rattus norvegicus	79-91
31610196-0	2019	The role of Wnt/beta-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia/reperfusion injury in rats.	Dexmedetomidine	66-81	catenin beta 1	Rattus norvegicus	16-28
31610196-1	2019	AIMS: To assess the role of glycogen synthase kinase-3beta (GSK3beta) and beta-catenin in the protection of ischemic injury by dexmedetomidine (Dex).	Dexmedetomidine	127-142	catenin beta 1	Rattus norvegicus	74-86
31610196-1	2019	AIMS: To assess the role of glycogen synthase kinase-3beta (GSK3beta) and beta-catenin in the protection of ischemic injury by dexmedetomidine (Dex).	Dexmedetomidine	144-147	catenin beta 1	Rattus norvegicus	74-86
31610196-5	2019	KEY FINDINGS: We found that the Dex-induced increment of neuron survival in the ischemic penumbra was diminished by the PI3K inhibitor LY294002 and the beta-catenin inhibitor XAV939, respectively.	Dexmedetomidine	32-35	catenin beta 1	Rattus norvegicus	152-164
31610196-6	2019	The increasing expression of pAKT, pGSK3beta and beta-catenin induced by Dex was markedly inhibited by LY294002.	Dexmedetomidine	73-76	catenin beta 1	Rattus norvegicus	49-61
31610196-6	2019	The increasing expression of pAKT, pGSK3beta and beta-catenin induced by Dex was markedly inhibited by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	103-111	catenin beta 1	Rattus norvegicus	49-61
31610196-7	2019	And the increasing expression of beta-catenin in nuclei induced by Dex was markedly inhibited by XAV939.	Dexmedetomidine	67-70	catenin beta 1	Rattus norvegicus	33-45
31610196-8	2019	At the same time, the GSK3beta inhibitor SB216763 also caused an increment of neuron survival and an increasing expression of pGSK3beta and beta-catenin in the ischemic penumbra.	SB 216763	41-49	catenin beta 1	Rattus norvegicus	140-152
31610196-9	2019	SIGNIFICANCE: Our data suggested that treatment with Dex reduced cerebral injury in rats exposed to cerebral ischemia-reperfusion (I/R) by the activation of the PI3K/AKT/GSK3beta pathways as well the activation of downstream Wnt/beta-catenin pathway.	Dexmedetomidine	53-56	catenin beta 1	Rattus norvegicus	229-241
31229551-4	2019	DM-celecoxib suppressed isoprenaline-induced neonatal rat cardiomyocyte hypertrophy by the inhibition of Akt phosphorylation resulting in the activation of GSK-3 and the inhibition of beta-catenin and mammalian target of rapamycin (mTOR).	dm-celecoxib	0-12	catenin beta 1	Rattus norvegicus	184-196
31412145-0	2019	Effect of sitagliptin on tubulointerstitial Wnt/beta-catenin signalling in diabetic nephropathy.	Sitagliptin Phosphate	10-21	catenin beta 1	Rattus norvegicus	48-60
31412145-1	2019	AIM: To investigate the effect of sitagliptin on Wnt/beta-catenin signalling in the tubulointerstitium of diabetic nephropathy.	Sitagliptin Phosphate	34-45	catenin beta 1	Rattus norvegicus	53-65
31412145-11	2019	In the high glucose-stimulated NRK-52E cells, sitagliptin and XAV939 inhibited the elevated expression of Wnt4, beta-catenin, dipeptidyl peptidase-4, alpha-smooth muscle actin, transforming growth factor-beta and fibronectin and restored E-cadherin activity.	Sitagliptin Phosphate	46-57	catenin beta 1	Rattus norvegicus	112-124
31412145-11	2019	In the high glucose-stimulated NRK-52E cells, sitagliptin and XAV939 inhibited the elevated expression of Wnt4, beta-catenin, dipeptidyl peptidase-4, alpha-smooth muscle actin, transforming growth factor-beta and fibronectin and restored E-cadherin activity.	XAV939	62-68	catenin beta 1	Rattus norvegicus	112-124
31412145-12	2019	CONCLUSION: Sitagliptin may inhibit the tubulointerstitial Wnt/beta-catenin signalling pathway in diabetic nephropathy and provide renal protection by alleviatinge renal tubulointerstitial transdifferentiation and fibrosis.	Sitagliptin Phosphate	12-23	catenin beta 1	Rattus norvegicus	63-75
31636691-20	2019	In rat primary OBs, PA treatment significantly decreased ALP activity and osteogenic gene and protein (beta-catenin, RUNX2, and osterix) expression, and ALA dose-dependently restored the inhibition induced by PA.	Palmitic Acid	20-22	catenin beta 1	Rattus norvegicus	103-115
31601982-0	2019	Effects of ghrelin on pGSK-3beta and beta-catenin expression when protects against neuropathic pain behavior in rats challenged with chronic constriction injury.	Ghrelin	11-18	catenin beta 1	Rattus norvegicus	37-49
31601982-2	2019	The purpose of this study was to investigate the role of GSK-3beta/beta-catenin signaling in mediating the effect of ghrelin on neuropathic pain and to understand the associated mechanisms.	Ghrelin	117-124	catenin beta 1	Rattus norvegicus	67-79
31601982-11	2019	Our data indicated that ghrelin could markedly alleviate neuropathic pain by inhibiting the expression of beta-catenin, via the suppression of GSK-3beta activation, in the spinal cord of CCI rats.	Ghrelin	24-31	catenin beta 1	Rattus norvegicus	106-118
31255704-0	2019	Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and beta-catenin binding in pancreatic beta-cells.	Oleic Acid	0-10	catenin beta 1	Rattus norvegicus	102-114
31078578-8	2019	We found decreased D1 receptor expression, mitochondrial biogenesis, mitochondrial functions and DAergic differentiation associated with down-regulation of Wnt/beta-catenin signalling in SNpc of 6-OHDA lesioned rats.	Oxidopamine	195-201	catenin beta 1	Rattus norvegicus	160-172
31423730-7	2019	Furthermore, SKL2001, an agonist of the Wnt/beta-catenin pathway, compromised the vascular protective effect of Rb1.	5-furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide	13-20	catenin beta 1	Rattus norvegicus	44-56
31423730-8	2019	GW9662, a PPAR-gamma antagonist, reversed Rb1"s inhibitory effect on beta-catenin.	2-chloro-5-nitrobenzanilide	0-6	catenin beta 1	Rattus norvegicus	69-81
31489803-12	2019	Our results suggest that the IGF-1R/beta-catenin signaling axis plays a role in the pathogenesis of DOP.	Diethylhexyl Phthalate	100-103	catenin beta 1	Rattus norvegicus	36-48
31667130-7	2019	It was confirmed that APPB inhibits N-glycosylation of beta-catenin at 2.5 nM concentration.	appb	22-26	catenin beta 1	Rattus norvegicus	55-67
31667130-7	2019	It was confirmed that APPB inhibits N-glycosylation of beta-catenin at 2.5 nM concentration.	Nitrogen	36-37	catenin beta 1	Rattus norvegicus	55-67
31525733-9	2019	In comparison, the blockage of Wnt/beta-catenin signaling pathway significantly alleviated the effect of H2S on osteoblasts.	Deuterium	105-108	catenin beta 1	Rattus norvegicus	35-47
31322244-11	2019	Furthermore, the expression of beta-catenin and RhoA was higher in the HSG + LiCl and HSG + HLY78 groups compared with the HSG group (P&lt;0.05).	WURCS=2.0/1,1,0/[a2211h-1a_1-5_1*OCCCCCCCC]/1/	71-74	catenin beta 1	Rattus norvegicus	31-43
31273605-0	2019	Correction to: Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/beta-Catenin Pathway.	bisphenol A	37-48	catenin beta 1	Rattus norvegicus	142-154
31212112-0	2019	Lithium-containing surface pre-reacted glass fillers enhance hDPSC functions and induce reparative dentin formation in a rat pulp capping model through activation of Wnt/beta-catenin signaling.	Lithium	0-7	catenin beta 1	Rattus norvegicus	170-182
31212112-4	2019	Previous work also showed that lithium ions can activate the Wnt/beta-catenin signaling pathway in vitro and induce dentin formation in pulpotomized teeth in vivo.	Lithium	31-38	catenin beta 1	Rattus norvegicus	65-77
31212112-9	2019	In conclusion, S-PRG/LiCl cement is highly effective in promoting human dental pulp stem cells profiles and in enhancing reparative dentin formation in rat teeth through activation of the Wnt/beta-catenin canonical signaling pathway.	s-prg	15-20	catenin beta 1	Rattus norvegicus	192-204
31212112-9	2019	In conclusion, S-PRG/LiCl cement is highly effective in promoting human dental pulp stem cells profiles and in enhancing reparative dentin formation in rat teeth through activation of the Wnt/beta-catenin canonical signaling pathway.	Lithium Chloride	21-25	catenin beta 1	Rattus norvegicus	192-204
31026457-9	2019	beta-Catenin antagonist (XAV939) was used to block LPS-mediated upregulation of iNOS, TNF-alpha, cyclin-D1, nitric oxide (NO) and the number of cells in the G2/M+S phase of cell cycle.	XAV939	25-31	catenin beta 1	Rattus norvegicus	0-12
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	Dinoprostone	56-60	catenin beta 1	Rattus norvegicus	40-52
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	208-217	catenin beta 1	Rattus norvegicus	40-52
31240382-8	2019	Finally, we show that the activation of beta-catenin by PGE2 required signaling through the phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase 3 beta (GSK3beta) pathway, as the PI3K inhibitor, LY-294002, disrupted the synergy between connexin43 and PGE2.	Dinoprostone	264-268	catenin beta 1	Rattus norvegicus	40-52
31564892-10	2019	beta-Catenin activator LiCl could significantly eliminate the effect of si-SHIP2 on BC cells.	Lithium Chloride	23-27	catenin beta 1	Rattus norvegicus	0-12
31026457-0	2019	Gastrodin attenuates proliferation and inflammatory responses in activated microglia through Wnt/beta-catenin signaling pathway.	gastrodin	0-9	catenin beta 1	Rattus norvegicus	97-109
31240382-0	2019	Connexin43 enhances Wnt and PGE2-dependent activation of beta-catenin in osteoblasts.	Dinoprostone	28-32	catenin beta 1	Rattus norvegicus	57-69
31053935-11	2019	Additionally, all three drugs elevated the activity of the Akt-GSK3beta signalling pathway in a time-dependent manner, while only aripiprazole stimulated the Dvl-3-GSK3beta-beta-catenin signalling pathway in the SN.	Aripiprazole	130-142	catenin beta 1	Rattus norvegicus	173-185
31497191-10	2019	Quercetin could increase the expression of ZO-1, Claudin-5, beta-catenin, and LEF1, and decrease the expression of MMP-9, GSK-3beta and Axin.	Quercetin	0-9	catenin beta 1	Rattus norvegicus	60-72
31497191-12	2019	Thus, quercetin can alleviate BBB dysfunction after global cerebral I/R in rats and the mechanism may be related to the activation of canonical Wnt/beta-catenin signaling pathway.	Quercetin	6-15	catenin beta 1	Rattus norvegicus	148-160
31026457-7	2019	In addition, the present results have shown that Gastrodin inhibited LPS-induced phosphorylation of glycogen synthase kinase-3beta (GSK-3beta) at Ser 9 and beta-catenin activity.	gastrodin	49-58	catenin beta 1	Rattus norvegicus	156-168
31026457-9	2019	beta-Catenin antagonist (XAV939) was used to block LPS-mediated upregulation of iNOS, TNF-alpha, cyclin-D1, nitric oxide (NO) and the number of cells in the G2/M+S phase of cell cycle.	Nitric Oxide	108-120	catenin beta 1	Rattus norvegicus	0-12
31026457-10	2019	Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia.	Lithium Chloride	25-29	catenin beta 1	Rattus norvegicus	45-57
31026457-10	2019	Moreover, treatment with LiCl, a special Wnt/beta-catenin pathway agonist significantly blocked Gastrodin-mediated down-regulation of iNOS, TNF-alpha, cyclin-D1, NO and the number of cells in the G2/M+S phase of cell cycle in LPS-stimulated BV-2 microglia.	gastrodin	96-105	catenin beta 1	Rattus norvegicus	45-57
31026457-11	2019	Taken together, the present results suggested that Gastrodin mediated anti-inflammatory and anti-proliferation effects in activated microglia by modulating the Wnt/beta-catenin signaling pathway.	gastrodin	51-60	catenin beta 1	Rattus norvegicus	164-176
31452866-0	2019	Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and beta-catenin pathway in AKI-to-CKD continuum.	Melatonin	9-18	catenin beta 1	Rattus norvegicus	111-123
31412883-16	2019	CONCLUSIONS: API can inhibit fibroblast proliferation and reduce epidural fibrosis by suppressing Wnt3a/beta-catenin signaling pathway, which can be adopted as a new option to prevent epidural fibrosis after the laminectomy.	Apigenin	13-16	catenin beta 1	Rattus norvegicus	104-116
31452866-0	2019	Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and beta-catenin pathway in AKI-to-CKD continuum.	poricoic acid A	23-38	catenin beta 1	Rattus norvegicus	111-123
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	Melatonin	83-92	catenin beta 1	Rattus norvegicus	140-152
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	poricoic acid A	97-100	catenin beta 1	Rattus norvegicus	140-152
31452866-9	2019	Melatonin and PAA also inhibited the Wnt/beta-catenin pathway and its profibrotic downstream targets, and PAA performed better.	Melatonin	0-9	catenin beta 1	Rattus norvegicus	41-53
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	poricoic acid A	97-100	catenin beta 1	Rattus norvegicus	140-152
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	poricoic acid A	177-180	catenin beta 1	Rattus norvegicus	55-67
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	Melatonin	83-92	catenin beta 1	Rattus norvegicus	140-152
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	poricoic acid A	177-180	catenin beta 1	Rattus norvegicus	140-152
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	poricoic acid A	177-180	catenin beta 1	Rattus norvegicus	140-152
31078692-10	2019	CONCLUSIONS: SSW effectively attenuated experimental chronic colitis induced by TNBS, which was realized by inhibition of the Wnt/beta-catenin signaling pathway.	Trinitrobenzenesulfonic Acid	80-84	catenin beta 1	Rattus norvegicus	130-142
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	Melatonin	221-230	catenin beta 1	Rattus norvegicus	55-67
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	Melatonin	221-230	catenin beta 1	Rattus norvegicus	140-152
31452866-10	2019	We further determined that IRI induced a nuclear Smad3/beta-catenin complex, while melatonin and PAA disturbed the interaction of Smad3 and beta-catenin, and supplementing with PAA could enhance the inhibitory effects of melatonin on the TGF-beta/Smad and Wnt/beta-catenin pathways.	Melatonin	221-230	catenin beta 1	Rattus norvegicus	140-152
31378908-0	2019	Effect of miR-124 on neuronal apoptosis in rats with cerebral infarction through Wnt/beta-catenin signaling pathway.	mir-124	10-17	catenin beta 1	Rattus norvegicus	85-97
31103702-10	2019	The involvement of Wnt/beta-catenin pathway was debatable; however, our findings showed that it was significantly induced by cisplatin.	Cisplatin	125-134	catenin beta 1	Rattus norvegicus	23-35
31103702-13	2019	Also, Wnt/beta-catenin pathway is partially involved in the pathogenesis of cisplatin nephrotoxicity.	Cisplatin	76-85	catenin beta 1	Rattus norvegicus	10-22
31378908-15	2019	In addition, miR-124 mimics significantly activated the expression levels of Wnt and beta-catenin (p&lt;0.05).	mir-124	13-20	catenin beta 1	Rattus norvegicus	85-97
31378908-16	2019	CONCLUSIONS: The inhibitory effect of miR-124 on neuronal apoptosis in CI rats is probably related to the activation of the Wnt/beta-catenin signaling pathway.	mir-124	38-45	catenin beta 1	Rattus norvegicus	128-140
31340453-0	2019	Dendrobium officinale Polysaccharides Inhibit 1-Methyl-2-Nitro-1-Nitrosoguanidine Induced Precancerous Lesions of Gastric Cancer in Rats through Regulating Wnt/beta-Catenin Pathway and Altering Serum Endogenous Metabolites.	1-methyl-2-nitro-1-nitrosoguanidine	46-81	catenin beta 1	Rattus norvegicus	160-172
31120770-2	2019	Although postconditioning with 8% oxygen can alleviate transient global cerebral ischemia (tGCI)-induced neuronal damage in hippocampal CA1 subregion in adult rats as demonstrated by our previous studies, little is understood about the role of Wnt/beta-catenin pathway in hypoxic postconditioning (HPC)-induced neuroprotection.	Oxygen	34-40	catenin beta 1	Rattus norvegicus	248-260
31120770-8	2019	Finally, the administration of LY294002, an inhibitor of PI3K, increased GSK-3beta activity and blocked nuclear beta-catenin accumulation, thereby decreasing survivin expression and elevating the Bax-to-Bcl-2 ratio after HPC.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	31-39	catenin beta 1	Rattus norvegicus	112-124
31526443-9	2019	Conclusion: Ginsenoside Rb1 and trigonelline could prevent the development of diabetic renal lesions by regulating the expression of miR-3550 and further associating with the Wnt/beta-catenin signaling.	trigonelline	32-44	catenin beta 1	Rattus norvegicus	179-191
31340453-4	2019	Treatment with DOP inhibited the progress of PLGC through decreasing the expression of beta-catenin by immunohistochemical analysis.	Diethylhexyl Phthalate	15-18	catenin beta 1	Rattus norvegicus	87-99
31340453-5	2019	The futher study indicated DOP downregulated gene expression of Wnt2beta, Gsk3beta, PCNA, CyclinD1, and beta-catenin, as well as protein expression of Wnt2beta, PCNA, and beta-catenin.	Diethylhexyl Phthalate	27-30	catenin beta 1	Rattus norvegicus	104-116
31340453-5	2019	The futher study indicated DOP downregulated gene expression of Wnt2beta, Gsk3beta, PCNA, CyclinD1, and beta-catenin, as well as protein expression of Wnt2beta, PCNA, and beta-catenin.	Diethylhexyl Phthalate	27-30	catenin beta 1	Rattus norvegicus	171-183
31340453-8	2019	DOP can inhibit MNNG-induced PLGC models via regulating Wnt/beta-catenin pathway and by changing endogenous metabolites.	Diethylhexyl Phthalate	0-3	catenin beta 1	Rattus norvegicus	60-72
31364145-0	2019	Influences of probiotics combined with sulfasalazine on rats with ulcerative colitis via the Wnt/beta-catenin signaling pathway.	Sulfasalazine	39-52	catenin beta 1	Rattus norvegicus	97-109
31026729-13	2019	Taken together, we showed that HSA attenuates GCI/R-induced brain damage and may be neuroprotective via regulation of the Wnt/beta-catenin/ROS signaling pathway.	ros	139-142	catenin beta 1	Rattus norvegicus	126-138
31364145-1	2019	OBJECTIVE: To investigate the influences of probiotics combined with sulfasalazine (SASP) on the expression of the Wnt/beta-catenin signaling pathway in rats with ulcerative colitis (UC).	Sulfasalazine	69-82	catenin beta 1	Rattus norvegicus	119-131
31355232-12	2019	In addition, the nuclear translocation of beta-catenin protein levels were increased in diabetic rats after the treatment of FK506.	Tacrolimus	125-130	catenin beta 1	Rattus norvegicus	42-54
30537190-8	2019	In conclusion, MSCs pretreated with resveratrol for 7 days showed increased 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and combined use of RSV (systemically and in culture media) significantly could improve cardiac remodeling capacity of MSCs via attenuation of sFRP2-mediated fibrosis and the downstream Wnt/beta-catenin pathway.	Resveratrol	36-47	catenin beta 1	Rattus norvegicus	340-352
31001900-0	2019	Klotho/FGF23 axis mediates high phosphate-induced vascular calcification in vascular smooth muscle cells via Wnt7b/beta-catenin pathway.	Phosphates	32-41	catenin beta 1	Rattus norvegicus	115-127
31001900-12	2019	Moreover, Wnt7b/beta-catenin inhibitor DKK1 could partly attenuate the effect of high phosphate on calcified VSMCs.	Phosphates	86-95	catenin beta 1	Rattus norvegicus	16-28
31001900-13	2019	These findings demonstrated that Klotho/FGF23 axis could modulate high phosphate-induced VSMCs calcification via Wnt7b/beta-catenin signaling pathway.	Phosphates	71-80	catenin beta 1	Rattus norvegicus	119-131
32641950-7	2019	Inhibition of PPAR- gamma/delta by FH535 (15 microM), an inhibitor of both Wnt/beta-catenin signaling and PPAR- gamma and delta activity, when applied in combination of Abeta not only worsen the toxic electrophysiological effects of Abeta on firing frequency, membrane resistance and cell viability, but also even preserved the suppressive effect of Abeta on Ca2+ channel current when compared to control condition.	FH535	35-40	catenin beta 1	Rattus norvegicus	79-91
31115524-0	2019	Costunolide inhibits matrix metalloproteinases expression and osteoarthritis via the NF-kappaB and Wnt/beta-catenin signaling pathways.	costunolide	0-11	catenin beta 1	Rattus norvegicus	103-115
31115524-7	2019	In addition, activation of the Wnt/beta-catenin signaling pathway was inhibited by costunolide, as demonstrated by the level of activation of beta-catenin and the transfer of beta-catenin into the nucleus induced by IL-1beta.	costunolide	83-94	catenin beta 1	Rattus norvegicus	35-47
31115524-7	2019	In addition, activation of the Wnt/beta-catenin signaling pathway was inhibited by costunolide, as demonstrated by the level of activation of beta-catenin and the transfer of beta-catenin into the nucleus induced by IL-1beta.	costunolide	83-94	catenin beta 1	Rattus norvegicus	142-154
31115524-7	2019	In addition, activation of the Wnt/beta-catenin signaling pathway was inhibited by costunolide, as demonstrated by the level of activation of beta-catenin and the transfer of beta-catenin into the nucleus induced by IL-1beta.	costunolide	83-94	catenin beta 1	Rattus norvegicus	142-154
31354246-0	2019	TMF inhibits miR-29a/Wnt/beta-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes.	methoxyluteolin	0-3	catenin beta 1	Rattus norvegicus	25-37
31354246-2	2019	Our previous work showed that 5,7,3",4"-tetramethoxyflavone (TMF), a major constituent from Murraya exotica L., exhibited chondroprotective activity by inhibiting the activity of Wnt/beta-catenin signaling.	methoxyluteolin	30-59	catenin beta 1	Rattus norvegicus	183-195
31354246-2	2019	Our previous work showed that 5,7,3",4"-tetramethoxyflavone (TMF), a major constituent from Murraya exotica L., exhibited chondroprotective activity by inhibiting the activity of Wnt/beta-catenin signaling.	methoxyluteolin	61-64	catenin beta 1	Rattus norvegicus	183-195
31354246-3	2019	Purpose: To investigate whether TMF showed the inhibitory effects on miR-29a/beta-catenin signaling by up regulation of Foxo3a expression.	methoxyluteolin	32-35	catenin beta 1	Rattus norvegicus	77-89
31354246-10	2019	TMF ameliorated miR-29a/beta-catenin-induced chondrocytes apoptosis by up regulation of Foxo3a expression.	methoxyluteolin	0-3	catenin beta 1	Rattus norvegicus	24-36
30940474-0	2019	Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury in rats by activating the Wnt/beta-catenin signaling pathway.	harpagide	0-9	catenin beta 1	Rattus norvegicus	126-138
30898547-6	2019	We further found that beta-catenin signaling plays an important role in LPA-induced OEC migration.	lysophosphatidic acid	72-75	catenin beta 1	Rattus norvegicus	22-34
30898547-7	2019	Moreover, silencing LPAR1 not only abolished the migration of OECs but also prevented ERK1/2 phosphorylation and beta-catenin activation, suggesting that LPAR1 ligation serves to activate the ERK1/2 and beta-catenin pathways in LPA-induced OEC chemotactic migration.	lysophosphatidic acid	20-23	catenin beta 1	Rattus norvegicus	113-125
30898547-7	2019	Moreover, silencing LPAR1 not only abolished the migration of OECs but also prevented ERK1/2 phosphorylation and beta-catenin activation, suggesting that LPAR1 ligation serves to activate the ERK1/2 and beta-catenin pathways in LPA-induced OEC chemotactic migration.	lysophosphatidic acid	20-23	catenin beta 1	Rattus norvegicus	203-215
31028181-0	2019	Dkk1 exacerbates doxorubicin-induced cardiotoxicity by inhibiting the Wnt/beta-catenin signaling pathway.	Doxorubicin	17-28	catenin beta 1	Rattus norvegicus	74-86
30797872-0	2019	FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3beta/ beta-catenin signaling pathway.	FCPR03	0-6	catenin beta 1	Rattus norvegicus	135-147
30710617-8	2019	In vitro, incubation with losartan prevented Wnt/beta-catenin-mediated fibronectin, alpha-smooth muscle actin and Snail1 expression, suggesting that the fibrogenic action of Wnt/beta-catenin is dependent on RAS activation.	Losartan	26-34	catenin beta 1	Rattus norvegicus	49-61
30710617-8	2019	In vitro, incubation with losartan prevented Wnt/beta-catenin-mediated fibronectin, alpha-smooth muscle actin and Snail1 expression, suggesting that the fibrogenic action of Wnt/beta-catenin is dependent on RAS activation.	Losartan	26-34	catenin beta 1	Rattus norvegicus	178-190
31210331-8	2019	According to the WB results, the protein expression levels of beta-catenin and Wnt3a in exosome treatment group were significantly higher than those in the blank control group and PBS injection group (p&lt;0.01).	pbs	180-183	catenin beta 1	Rattus norvegicus	62-74
30957181-5	2019	Overexpression of miR-15a-5p promoted the apoptosis of BMSCs and reduced cell growth through the Wnt/beta-catenin/peroxisome proliferator-activated receptor gamma (PPARgamma) signaling pathway.	mir-15a-5p	18-28	catenin beta 1	Rattus norvegicus	101-113
30957181-6	2019	Downregulation of miR-15a-5p reduced the apoptosis of BMSCs and promoted cell growth through the Wnt/beta-catenin/PPARgamma signaling pathway.	mir-15a-5p	18-28	catenin beta 1	Rattus norvegicus	101-113
30957181-7	2019	The activation of Wnt attenuated the effects of miR-15a-5p on the apoptosis of BMSCs via the beta-catenin/PPARgamma signaling pathway.	mir-15a-5p	48-58	catenin beta 1	Rattus norvegicus	93-105
31028181-8	2019	Adenovirus encoding Dkk1 was transduced through intramyocardial injection and exacerbated Dox-induced cardiomyocyte apoptosis, mitochondrial damage and heart injury in vivo Furthermore, Wnt/beta-catenin signaling was inhibited during Dox-induced cardiotoxicity, and the re-activation of beta-catenin prevented the effect of overexpressed Dkk1 and Dox-induced cardiotoxicity.	Doxorubicin	90-93	catenin beta 1	Rattus norvegicus	190-202
31028181-8	2019	Adenovirus encoding Dkk1 was transduced through intramyocardial injection and exacerbated Dox-induced cardiomyocyte apoptosis, mitochondrial damage and heart injury in vivo Furthermore, Wnt/beta-catenin signaling was inhibited during Dox-induced cardiotoxicity, and the re-activation of beta-catenin prevented the effect of overexpressed Dkk1 and Dox-induced cardiotoxicity.	Doxorubicin	90-93	catenin beta 1	Rattus norvegicus	287-299
31028181-8	2019	Adenovirus encoding Dkk1 was transduced through intramyocardial injection and exacerbated Dox-induced cardiomyocyte apoptosis, mitochondrial damage and heart injury in vivo Furthermore, Wnt/beta-catenin signaling was inhibited during Dox-induced cardiotoxicity, and the re-activation of beta-catenin prevented the effect of overexpressed Dkk1 and Dox-induced cardiotoxicity.	Doxorubicin	234-237	catenin beta 1	Rattus norvegicus	190-202
31028181-8	2019	Adenovirus encoding Dkk1 was transduced through intramyocardial injection and exacerbated Dox-induced cardiomyocyte apoptosis, mitochondrial damage and heart injury in vivo Furthermore, Wnt/beta-catenin signaling was inhibited during Dox-induced cardiotoxicity, and the re-activation of beta-catenin prevented the effect of overexpressed Dkk1 and Dox-induced cardiotoxicity.	Doxorubicin	234-237	catenin beta 1	Rattus norvegicus	190-202
31028181-9	2019	In conclusion, these results reveal the crucial role of the Dkk1-Wnt/beta-catenin signaling axis in the process of Dox-induced cardiotoxicity and provide novel insights into the potential mechanism of cardiomyopathy caused by clinical application of Dox.	Doxorubicin	115-118	catenin beta 1	Rattus norvegicus	69-81
31028181-9	2019	In conclusion, these results reveal the crucial role of the Dkk1-Wnt/beta-catenin signaling axis in the process of Dox-induced cardiotoxicity and provide novel insights into the potential mechanism of cardiomyopathy caused by clinical application of Dox.	Doxorubicin	250-253	catenin beta 1	Rattus norvegicus	69-81
30940474-4	2019	In this study, we demonstrated that harpagide attenuated neuronal apoptosis via activation of the Wnt/beta-catenin signaling pathway.	harpagide	36-45	catenin beta 1	Rattus norvegicus	102-114
30940474-6	2019	Specifically, the administration of harpagide after SCI increased the expression levels of beta-catenin, c-myc and cyclin D1 proteins in spinal cord neurons, as well as increased the number of motor neurons and reduced the size of the SCI lesion area.	harpagide	36-45	catenin beta 1	Rattus norvegicus	91-103
30940474-9	2019	When the Wnt /beta-catenin signaling pathway was inhibited, a weakened anti-apoptotic effect of harpagide was observed.	harpagide	96-105	catenin beta 1	Rattus norvegicus	14-26
31035577-9	2019	Further, we demonstrate that inhibition of beta-catenin/CBP interaction by ICG-001 decreased the amount of phosphorylated Smad3 upon TGF-beta stimulation in addition to significantly decreasing the expression levels of TGF-beta receptors, TBRII and TBRI.	Indocyanine Green	75-78	catenin beta 1	Rattus norvegicus	43-55
30864714-0	2019	ERalpha and Wnt/beta-catenin signaling pathways are involved in angelicin-dependent promotion of osteogenesis.	angelicin	64-73	catenin beta 1	Rattus norvegicus	16-28
30864714-5	2019	Furthermore, angelicin promoted the expression of beta-catenin and runt related transcription factor 2, which serve a vital role in the Wnt/beta-catenin signaling pathway.	angelicin	13-22	catenin beta 1	Rattus norvegicus	50-62
30864714-5	2019	Furthermore, angelicin promoted the expression of beta-catenin and runt related transcription factor 2, which serve a vital role in the Wnt/beta-catenin signaling pathway.	angelicin	13-22	catenin beta 1	Rattus norvegicus	140-152
30864714-8	2019	Taken together, these results demonstrated that angelicin may promote osteoblast differentiation through activation of ERalpha and the Wnt/beta-catenin signaling pathway.	angelicin	48-57	catenin beta 1	Rattus norvegicus	139-151
31068290-4	2019	CONCLUSIONS: Mafb expression increases progressively with the development of GTs in male SD rats.DEHP exposure causes significant down-regulation of Mafb and beta-catenin, suggesting that beta-catenin signaling pathway that affects Mafb is related to DEHP-induced hypospadias in SD rats.	Glutathionesulfonic acid	77-80	catenin beta 1	Rattus norvegicus	158-170
31068290-4	2019	CONCLUSIONS: Mafb expression increases progressively with the development of GTs in male SD rats.DEHP exposure causes significant down-regulation of Mafb and beta-catenin, suggesting that beta-catenin signaling pathway that affects Mafb is related to DEHP-induced hypospadias in SD rats.	Glutathionesulfonic acid	77-80	catenin beta 1	Rattus norvegicus	188-200
31061622-0	2019	In vitro wound healing activity of 1-hydroxy-5,7-dimethoxy-2-naphthalene-carboxaldehyde (HDNC) and other isolates of Aegle marmelos L.: Enhances keratinocytes motility via Wnt/beta-catenin and RAS-ERK pathways.	1-hydroxy-5,7-dimethoxy-2-naphthalenecarboxaldehyde	35-87	catenin beta 1	Rattus norvegicus	176-188
31119171-7	2019	Additionally, glutamine treatment increased SOD and GSH-XP activity and decreased MDA content and increased Wnt3a and beta-catenin protein levels.	Glutamine	14-23	catenin beta 1	Rattus norvegicus	118-130
31111002-11	2019	Treadmill exercise and fluoxetine treatment also enhanced GSK3beta phosphorylation and suppressed beta-catenin phosphorylation in the hippocampus.	Fluoxetine	23-33	catenin beta 1	Rattus norvegicus	98-110
31119171-8	2019	Interestingly, the DKK-1 (Wnt3a/beta-catenin pathway inhibitor) decreased the antioxidant capacity of glutamine in Abeta25-35-treated PC12 cells.	Glutamine	102-111	catenin beta 1	Rattus norvegicus	32-44
31168987-13	2019	The number of calcium nodules of BMSCs; alkaline phosphatase activity; and the mRNA expression of Runx2, OCN, Osx, Col-I, CyclinD1, beta-catenin in the high glucose group were lower than those in the normal control and ASP+high glucose groups (P&lt;0.05).	Glucose	157-164	catenin beta 1	Rattus norvegicus	132-144
30904419-13	2019	In conclusion, our study reveals that resveratrol or DMF exert profound testicular protective effects in CUMS rats that are mediated in part by suppressing oxidative stress, inflammation, and apoptosis leading to the upregulation of serum testosterone levels, and testicular StAR, CYP450scc, c-kit and beta-catenin levels.	Resveratrol	38-49	catenin beta 1	Rattus norvegicus	302-314
30904419-13	2019	In conclusion, our study reveals that resveratrol or DMF exert profound testicular protective effects in CUMS rats that are mediated in part by suppressing oxidative stress, inflammation, and apoptosis leading to the upregulation of serum testosterone levels, and testicular StAR, CYP450scc, c-kit and beta-catenin levels.	Dimethyl Fumarate	53-56	catenin beta 1	Rattus norvegicus	302-314
30726711-8	2019	KEY FINDINGS: Results showed that paraquat induced lung injury characterized by enhanced oxidative stress and inflammation, upregulated RAGE, HMGB1 gene expression, PI3K/Akt and beta-catenin protein expression.	Paraquat	34-42	catenin beta 1	Rattus norvegicus	178-190
30504694-7	2019	At 4 weeks, the area of mineralized new bone statistically increased in BO+DOX compared to BO, upregulations of TGFbeta1, BMP2 and beta-catenin were evident in BO+DOX.	Doxycycline	163-166	catenin beta 1	Rattus norvegicus	131-143
30726711-9	2019	Administration of febuxostat inhibited the deleterious effects of paraquat on lung through inhibition of xanthine oxidase activity and related oxidative stress, downregulation of RAGE/PI3K/Akt pathway, and suppression of beta-catenin protein expression and its downstream inflammatory mediators.	Febuxostat	18-28	catenin beta 1	Rattus norvegicus	221-233
30726711-9	2019	Administration of febuxostat inhibited the deleterious effects of paraquat on lung through inhibition of xanthine oxidase activity and related oxidative stress, downregulation of RAGE/PI3K/Akt pathway, and suppression of beta-catenin protein expression and its downstream inflammatory mediators.	Paraquat	66-74	catenin beta 1	Rattus norvegicus	221-233
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	catenin beta 1	Rattus norvegicus	67-79
30710837-12	2019	CONCLUSION: Both cPTH and iPTH promote midpalatal suture expansion by enhancing bone formation, probably via SOST downregulation and the resulting beta-catenin activation.	cpth	17-21	catenin beta 1	Rattus norvegicus	147-159
30710837-12	2019	CONCLUSION: Both cPTH and iPTH promote midpalatal suture expansion by enhancing bone formation, probably via SOST downregulation and the resulting beta-catenin activation.	ipth	26-30	catenin beta 1	Rattus norvegicus	147-159
30656849-0	2019	Diminished membrane recruitment of Akt is instrumental in alcohol-associated osteopenia via the PTEN/Akt/GSK-3beta/beta-catenin axis.	Alcohols	58-65	catenin beta 1	Rattus norvegicus	115-127
30656849-2	2019	Our previous research indicated that the Akt/GSK-3beta/beta-catenin pathway plays a critical role in the ethanol-induced antiosteogenic effect in bone mesenchymal stem cells (BMSCs).	Ethanol	105-112	catenin beta 1	Rattus norvegicus	55-67
30656849-9	2019	In summary, the ethanol-mediated transcriptional and post-transcriptional regulation of PTEN impaired downstream Akt/GSK3beta/beta-catenin signaling and BMSC osteogenic differentiation.	Ethanol	16-23	catenin beta 1	Rattus norvegicus	126-138
30656849-10	2019	Therefore, we propose that Akt/GSK3beta/beta-catenin activation via PTEN inhibition may be a potential therapeutic approach for preventing the development of alcohol-induced osteopenia.	Alcohols	158-165	catenin beta 1	Rattus norvegicus	40-52
30616171-0	2019	Vitamin D alleviates airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	0-9	catenin beta 1	Rattus norvegicus	88-100
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	34-43	catenin beta 1	Rattus norvegicus	298-310
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	catenin beta 1	Rattus norvegicus	67-79
30616171-5	2019	The putative signaling pathway of vitamin D was based on Wnt5a and beta-catenin expression assessed by quantitative real-time reverse transcription polymerase chain reaction (RT-qPCR) and Western blot, which revealed that the administration of vitamin D significantly decreased the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	244-253	catenin beta 1	Rattus norvegicus	298-310
30616171-6	2019	These results suggested that administration of vitamin D alleviated the airway remodeling in asthma by down-regulating the activity of Wnt/beta-catenin signaling pathway.	Vitamin D	47-56	catenin beta 1	Rattus norvegicus	139-151
30664209-0	2019	Upregulation of miR-33b promotes endometriosis via inhibition of Wnt/beta-catenin signaling and ZEB1 expression.	mir-33b	16-23	catenin beta 1	Rattus norvegicus	69-81
30664209-8	2019	In conclusion, the present study demonstrated that upregulation of miR-33b may promote Ems through Wnt/beta-catenin by ZEB1 expression.	mir-33b	67-74	catenin beta 1	Rattus norvegicus	103-115
30664209-5	2019	In addition, miR-33b up-regulation reduced Wnt/beta-catenin signaling pathway and suppressed zinc finger E-box-binding homeobox 1 (ZEB1) protein expression in the in vitro Ems model (primary cell cultures) compared with the control group.	mir-33b	13-20	catenin beta 1	Rattus norvegicus	47-59
30808932-0	2019	Mianserin suppresses R-spondin 2-induced activation of Wnt/beta-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis.	Mianserin	0-9	catenin beta 1	Rattus norvegicus	59-71
30890512-7	2019	Compared with those in the control offspring rats, Gsk-3beta expression increased significantly while the expressions of beta-catenin and Wnt1 were significantly lowered in the hippocampus of the offspring rats in PS group (P &amp;lt; 0.01).	ps	214-216	catenin beta 1	Rattus norvegicus	121-133
30890512-7	2019	Compared with those in the control offspring rats, Gsk-3beta expression increased significantly while the expressions of beta-catenin and Wnt1 were significantly lowered in the hippocampus of the offspring rats in PS group (P &amp;lt; 0.01).	Adenosine Monophosphate	183-186	catenin beta 1	Rattus norvegicus	121-133
30890512-8	2019	CONCLUSIONS: PS causes changes in Wnt/beta-catenin signaling pathway in the hippocampus to contribute to the occurrence of depression-and anxiety-like behaviors in rats.	ps	13-15	catenin beta 1	Rattus norvegicus	38-50
30818817-0	2019	Vitamin C Activates Osteoblastogenesis and Inhibits Osteoclastogenesis via Wnt/beta-Catenin/ATF4 Signaling Pathways.	Ascorbic Acid	0-9	catenin beta 1	Rattus norvegicus	79-91
30808932-9	2019	We also observed that intraarticular administration of mianserin suppressed beta-catenin accumulation and prevented OA progression in a rat model of OA.	Mianserin	55-64	catenin beta 1	Rattus norvegicus	76-88
30808932-10	2019	We conclude that mianserin suppresses abnormally activated Wnt/beta-catenin signaling in OA by inhibiting binding of Rspo2 to Lgr5.	Mianserin	17-26	catenin beta 1	Rattus norvegicus	63-75
30530044-0	2019	Wnt/beta-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorbeta1/Smad3 signaling pathway.	Isoflurane	50-60	catenin beta 1	Rattus norvegicus	4-16
30395900-8	2019	Finally, Sappanone A significantly activated Wnt/beta-catenin and PI3K/AKT signaling pathways.	sappanone	9-18	catenin beta 1	Rattus norvegicus	49-61
30395900-11	2019	One of the possible mechanisms of the neuroprotective effect is that: Sappanone A down-regulated the expression of miR-15a, and thus activated Wnt/beta-catenin and PI3K/AKT signaling pathways.	sappanone A	70-81	catenin beta 1	Rattus norvegicus	147-159
30377735-6	2019	Adding the anti-sFRP1 antibody (0.5 microg/ml) and inhibiting sFRP1 secretion by caffeine (5 mM) both relieved Dox-induced cardiotoxicity through activating Wnt/beta-catenin signaling, whereas increasing the secretion of sFRP1 by heparin (100 microg/ml) had the opposite effect.	Doxorubicin	111-114	catenin beta 1	Rattus norvegicus	161-173
30291843-0	2019	Loss of Sfrp2 contributes to the neurological disorders related with morphine withdrawal via Wnt/beta-catenin signaling.	Morphine	69-77	catenin beta 1	Rattus norvegicus	97-109
30291843-3	2019	Recent studies have revealed that the upregulation of Wnt/beta-catenin signaling plays important roles in morphine exposure and morphine withdrawal.	Morphine	106-114	catenin beta 1	Rattus norvegicus	58-70
30291843-3	2019	Recent studies have revealed that the upregulation of Wnt/beta-catenin signaling plays important roles in morphine exposure and morphine withdrawal.	Morphine	128-136	catenin beta 1	Rattus norvegicus	58-70
30530044-13	2019	However, the expression level of beta-catenin in nuclear and cytoplasm both decreased significantly after pre-injection with the TGF-beta1 inhibitor(LY2157299) and Smad3 inhibitor(SIS3), whereas the expression levels of TGF-beta1, Smad3 and p-Smad3 were almost unchanged.	LY-2157299	149-158	catenin beta 1	Rattus norvegicus	33-45
30530044-10	2019	In the MCAO + ISO group, the neurological deficit score, infarct volumes and neuron apoptosis reduced significantly, the expression levels of Wnt3a, beta-catenin, VEGF and Cyclin D1 increased, while the expression level of GSK-3beta and Caspase 3 decreased relative to MCAO group.	Isoproterenol	14-17	catenin beta 1	Rattus norvegicus	149-161
30670092-9	2019	In addition, the enhanced osteogenesis due to catalpol treatment was partially reversed by a Wnt/beta-catenin antagonist.	catalpol	46-54	catenin beta 1	Rattus norvegicus	97-109
31456460-13	2019	The expression of beta-catenin and phosphorylation of PI3K and AKT were upregulated by GTP, while MALAT1 knockdown led to opposite results.	Guanosine Triphosphate	87-90	catenin beta 1	Rattus norvegicus	18-30
30060123-11	2019	Furthermore, PGE2 increased protein levels of GJA1, phospho-GJA1, phospho-AKT, CTNNB1, and phospho-CTNNB1.	Dinoprostone	13-17	catenin beta 1	Rattus norvegicus	79-85
30060123-11	2019	Furthermore, PGE2 increased protein levels of GJA1, phospho-GJA1, phospho-AKT, CTNNB1, and phospho-CTNNB1.	Dinoprostone	13-17	catenin beta 1	Rattus norvegicus	99-105
30606985-6	2019	A 0.1 microM dose of norgalanthamine also increased phosphorylation of AKT, which was followed by an increase in glycogen synthase kinase 3beta phosphorylation and nuclear translocation of beta-catenin.	norgalanthamine	21-36	catenin beta 1	Rattus norvegicus	189-201
30606985-8	2019	These results suggest that norgalanthamine can stimulate the anagen phase of the hair cycle in DPCs via activation of the ERK 1/2, PI3K/AKT, and Wnt/beta-catenin pathways.	norgalanthamine	27-42	catenin beta 1	Rattus norvegicus	149-161
30273876-0	2019	Chronic fluoride exposure induces neuronal apoptosis and impairs neurogenesis and synaptic plasticity: Role of GSK-3beta/beta-catenin pathway.	Fluorides	8-16	catenin beta 1	Rattus norvegicus	121-133
30273876-2	2019	In the present study, we firstly evaluated the glycogen synthase kinase 3beta (GSK-3beta)/beta-catenin pathway in the hippocampus of rats exposed to fluoride, given the well-established role of GSK-3beta/beta-catenin pathway in neuronal death and survival.	Fluorides	149-157	catenin beta 1	Rattus norvegicus	90-102
30308130-6	2019	Administration of PTZ caused a significant increase in seizure score and duration, induced a state of oxidative stress (high malondialdehyde, low reduced glutathione and catalase activity), and led to the upregulation of beta-catenin, caspase-3, and its cleavage products, Hsp70 and alpha-synuclein, in hippocampal regions as well as a significant reduction in seizure latency.	Pentylenetetrazole	18-21	catenin beta 1	Rattus norvegicus	221-233
30326193-0	2019	Role of Wnt/beta-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis.	5-furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide	41-48	catenin beta 1	Rattus norvegicus	12-24
30326193-0	2019	Role of Wnt/beta-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis.	Ceruletide	52-61	catenin beta 1	Rattus norvegicus	12-24
30326193-1	2019	The goal of this study was to clarify the protective role of the Wnt/beta-catenin pathway agonist SKL2001 in a rat model of Caerulein-induced acute pancreatitis.	5-furan-2yl-isoxazole-3-carboxylic acid (3-imidazol-1yl-propyl)-amide	98-105	catenin beta 1	Rattus norvegicus	69-81
30326193-1	2019	The goal of this study was to clarify the protective role of the Wnt/beta-catenin pathway agonist SKL2001 in a rat model of Caerulein-induced acute pancreatitis.	Ceruletide	124-133	catenin beta 1	Rattus norvegicus	69-81
30326193-6	2019	In vitro results showed that Caerulein promoted cell necrosis, inhibited the Wnt/beta-catenin pathway, and increased the level of inflammatory cytokines.	Ceruletide	29-38	catenin beta 1	Rattus norvegicus	81-93
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	69-72	catenin beta 1	Rattus norvegicus	28-40
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	69-72	catenin beta 1	Rattus norvegicus	153-165
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	69-72	catenin beta 1	Rattus norvegicus	153-165
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	28-40
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	153-165
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	153-165
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	28-40
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	153-165
30273876-7	2019	Correspondingly, downstream beta-catenin signaling was undermined by NaF treatment as evidenced by the fact that both two doses of NaF decreased nucleus beta-catenin status and the higher dose of NaF also reduced cytoplasmic beta-catenin protein expression.	Sodium Fluoride	131-134	catenin beta 1	Rattus norvegicus	153-165
30273876-8	2019	Taken together, the present study firstly showed the aberrant changes of GSK-3beta/beta-catenin signaling in the fluoride-exposed brain, highlighting the involvement of GSK-3beta/beta-catenin signaling in the fluoride-induced neurotoxicity.	Fluorides	113-121	catenin beta 1	Rattus norvegicus	83-95
30273876-8	2019	Taken together, the present study firstly showed the aberrant changes of GSK-3beta/beta-catenin signaling in the fluoride-exposed brain, highlighting the involvement of GSK-3beta/beta-catenin signaling in the fluoride-induced neurotoxicity.	Fluorides	113-121	catenin beta 1	Rattus norvegicus	179-191
30273876-8	2019	Taken together, the present study firstly showed the aberrant changes of GSK-3beta/beta-catenin signaling in the fluoride-exposed brain, highlighting the involvement of GSK-3beta/beta-catenin signaling in the fluoride-induced neurotoxicity.	Fluorides	209-217	catenin beta 1	Rattus norvegicus	83-95
30273876-8	2019	Taken together, the present study firstly showed the aberrant changes of GSK-3beta/beta-catenin signaling in the fluoride-exposed brain, highlighting the involvement of GSK-3beta/beta-catenin signaling in the fluoride-induced neurotoxicity.	Fluorides	209-217	catenin beta 1	Rattus norvegicus	179-191
30194656-0	2019	Geraniin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via activating beta-catenin: a comparative study between BMSCs from normal and osteoporotic rats.	Geraniin	0-8	catenin beta 1	Rattus norvegicus	106-118
30194656-13	2019	This study associated the osteogenic effect of geraniin to activation of Wnt/beta-catenin signaling, and provided rationale for pharmacological investigation of geraniin in osteoporosis prevention and treatment.	Geraniin	47-55	catenin beta 1	Rattus norvegicus	77-89
29802483-0	2018	Expression of beta-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats.	Cisplatin	60-69	catenin beta 1	Rattus norvegicus	14-26
30500462-0	2019	Dopamine D1 receptor activation improves adult hippocampal neurogenesis and exerts anxiolytic and antidepressant-like effect via activation of Wnt/beta-catenin pathways in rat model of Parkinson"s disease.	Dopamine	0-8	catenin beta 1	Rattus norvegicus	147-159
30662673-8	2018	In vitro, TNF-alpha led to the activation of nuclear factor-kappa B (NF-kappaB) and the degradation of beta-catenin, which were significantly inhibited by quercetin.	Quercetin	155-164	catenin beta 1	Rattus norvegicus	103-115
30336136-6	2018	Our results showed lithium chloride inhibited glycogen synthase kinase-3beta activation, which on one hand, suppressed downstream CRMP-2/NR2B, thus diminishing the excitotoxic index level; and on the other, stabilized beta-catenin, thus modulating its downstream apoptosis-related factors such as NF-kappaB, Bcl-2 and Bax.	Lithium Chloride	19-35	catenin beta 1	Rattus norvegicus	218-230
30632435-8	2019	In sham rats, SB216763 upregulated both beta-catenin and BDNF in spinal dorsal horn but affect neither of them in hippocampus.	SB 216763	14-22	catenin beta 1	Rattus norvegicus	40-52
30244113-13	2018	In conclusion, our study revealed that resveratrol and DMF exerted promising antidepressant-like effects in CUMS rats that are mediated in part by suppressing the neuroinflammation, oxidative stress, apoptosis and up-regulating hippocampal BDNF and beta-catenin levels.	Resveratrol	39-50	catenin beta 1	Rattus norvegicus	249-261
30244113-13	2018	In conclusion, our study revealed that resveratrol and DMF exerted promising antidepressant-like effects in CUMS rats that are mediated in part by suppressing the neuroinflammation, oxidative stress, apoptosis and up-regulating hippocampal BDNF and beta-catenin levels.	Dimethyl Fumarate	55-58	catenin beta 1	Rattus norvegicus	249-261
29802483-6	2018	Interestingly, in CDDP-induced AKI, the regenerating proximal renal tubular epithelial cells reacting strongly with Ki67 expressed membranous or cytoplasmic beta-catenin and also showed a positive reaction to vimentin but not to alpha-SMA.	Cisplatin	18-22	catenin beta 1	Rattus norvegicus	157-169
29802483-6	2018	Interestingly, in CDDP-induced AKI, the regenerating proximal renal tubular epithelial cells reacting strongly with Ki67 expressed membranous or cytoplasmic beta-catenin and also showed a positive reaction to vimentin but not to alpha-SMA.	ki67	116-120	catenin beta 1	Rattus norvegicus	157-169
29802483-2	2018	Here, the expression of beta-catenin was investigated in the proximal renal tubular epithelial cells in cisplatin (CDDP)-induced acute kidney injury (AKI) and chronic kidney injury (CKI), because CDDP-induced renal lesions were characterized by proximal renal tubular epithelial degeneration/regeneration and subsequent interstitial fibrosis.	Cisplatin	104-113	catenin beta 1	Rattus norvegicus	24-36
29802483-2	2018	Here, the expression of beta-catenin was investigated in the proximal renal tubular epithelial cells in cisplatin (CDDP)-induced acute kidney injury (AKI) and chronic kidney injury (CKI), because CDDP-induced renal lesions were characterized by proximal renal tubular epithelial degeneration/regeneration and subsequent interstitial fibrosis.	Cisplatin	115-119	catenin beta 1	Rattus norvegicus	24-36
29802483-2	2018	Here, the expression of beta-catenin was investigated in the proximal renal tubular epithelial cells in cisplatin (CDDP)-induced acute kidney injury (AKI) and chronic kidney injury (CKI), because CDDP-induced renal lesions were characterized by proximal renal tubular epithelial degeneration/regeneration and subsequent interstitial fibrosis.	Cisplatin	196-200	catenin beta 1	Rattus norvegicus	24-36
30083945-0	2018	Vinpocetine halts ketamine-induced schizophrenia-like deficits in rats: impact on BDNF and GSK-3beta/beta-catenin pathway.	vinpocetine	0-11	catenin beta 1	Rattus norvegicus	101-113
30466619-6	2018	The overexpression of endothelin-1 (ET-1) and ETA receptor occurred in the PAH rats was significantly attenuated by magnolol through inhibition of Akt/ERK1/2/GSK3beta/beta-catenin pathway.	magnolol	116-124	catenin beta 1	Rattus norvegicus	167-179
30176346-5	2018	We demonstrate that single unilateral injection of 6-OHDA into the medial forebrain bundle (MFB) potentially dysregulates Wnt/beta-catenin signaling in substantia nigra pars compacta (SNpc).	Oxidopamine	51-57	catenin beta 1	Rattus norvegicus	126-138
30305219-4	2018	Furthermore, nano TiO2-induced the toxicity of primary cultured rat SCs was associated with increased expression of Wnt1, Wnt3a, Wnt5a, Wnt11, and beta-catenin and involved with reduced p-GSK-3beta expression.	titanium dioxide	18-22	catenin beta 1	Rattus norvegicus	147-159
30306652-7	2018	Altogether, it is suggestive that RSM improves bone quantity and quality by favoring Wnt/beta-catenin and OPG/RANKL/cathepsin K signaling pathways in OVX rats thereby suggesting the potential of this herb to be a novel source of antiosteoporosis drugs.	(2s)-2-(Acetylamino)-N-Methyl-4-[(R)-Methylsulfinyl]butanamide	34-37	catenin beta 1	Rattus norvegicus	89-101
30083945-10	2018	Also, ketamine induced a reduced level of BDNF together with the potentiation of GSK-3beta/beta-catenin pathway that led to the destruction of beta-catenin.	Ketamine	6-14	catenin beta 1	Rattus norvegicus	91-103
30083945-10	2018	Also, ketamine induced a reduced level of BDNF together with the potentiation of GSK-3beta/beta-catenin pathway that led to the destruction of beta-catenin.	Ketamine	6-14	catenin beta 1	Rattus norvegicus	143-155
30083945-12	2018	Vinpocetine also elevated BDNF expression and prevented ketamine-induced stimulation of the GSK-3beta/beta-catenin signaling.	vinpocetine	0-11	catenin beta 1	Rattus norvegicus	102-114
30083945-12	2018	Vinpocetine also elevated BDNF expression and prevented ketamine-induced stimulation of the GSK-3beta/beta-catenin signaling.	Ketamine	56-64	catenin beta 1	Rattus norvegicus	102-114
30497456-0	2018	Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/beta-catenin pathway.	Lanthanum phosphate	0-19	catenin beta 1	Rattus norvegicus	103-115
30622965-0	2018	Dexmedetomidine Reduces Diabetic Neuropathy Pain in Rats through the Wnt 10a/beta-Catenin Signaling Pathway.	Dexmedetomidine	0-15	catenin beta 1	Rattus norvegicus	77-89
30622965-3	2018	In the present study, we aimed to evaluate the role of Wnt 10a/beta-catenin signaling in DEX-induced alleviation of DNP in rats.	Dexmedetomidine	89-92	catenin beta 1	Rattus norvegicus	63-75
30622965-3	2018	In the present study, we aimed to evaluate the role of Wnt 10a/beta-catenin signaling in DEX-induced alleviation of DNP in rats.	dnp	116-119	catenin beta 1	Rattus norvegicus	63-75
30622965-8	2018	Rats with STZ-induced DNP had a decreased pain threshold, activated astrocytes, increased expression of Wnt 10a and beta-catenin, and increased levels of proinflammatory cytokines compared to the control group, and these effects were ameliorated by treatment with DEX.	Streptozocin	10-13	catenin beta 1	Rattus norvegicus	116-128
30622965-8	2018	Rats with STZ-induced DNP had a decreased pain threshold, activated astrocytes, increased expression of Wnt 10a and beta-catenin, and increased levels of proinflammatory cytokines compared to the control group, and these effects were ameliorated by treatment with DEX.	dnp	22-25	catenin beta 1	Rattus norvegicus	116-128
30622965-10	2018	In conclusion, DEX alleviated DNP in rats by inhibiting inflammation and astrocyte activation, which may be attributed to downregulation of the Wnt 10a/beta-catenin signaling pathway.	Dexmedetomidine	15-18	catenin beta 1	Rattus norvegicus	152-164
30622965-10	2018	In conclusion, DEX alleviated DNP in rats by inhibiting inflammation and astrocyte activation, which may be attributed to downregulation of the Wnt 10a/beta-catenin signaling pathway.	dnp	30-33	catenin beta 1	Rattus norvegicus	152-164
30428918-0	2018	Bone marrow mesenchymal stromal cells attenuate silica-induced pulmonary fibrosis potentially by attenuating Wnt/beta-catenin signaling in rats.	Silicon Dioxide	48-54	catenin beta 1	Rattus norvegicus	113-125
30336147-9	2018	In addition, ATS treatment may decrease the HIF-1alpha and beta-catenin levels both in vivo and in vitro.	Atorvastatin	13-16	catenin beta 1	Rattus norvegicus	59-71
30428918-11	2018	Furthermore, we found that Wnt/beta-catenin signaling pathway is abnormally activated in silica-induced pulmonary fibrosis, and exogenous transplantation of BMSCs may attenuate their expression.	Silicon Dioxide	89-95	catenin beta 1	Rattus norvegicus	31-43
30060293-8	2018	DKK1, a Wnt/beta-catenin signaling inhibitor, significantly suppressed the taurine-induced Nrf2 signaling pathway and increased CHOP.	Taurine	75-82	catenin beta 1	Rattus norvegicus	12-24
30153562-0	2018	A collagen microchannel scaffold carrying paclitaxel-liposomes induces neuronal differentiation of neural stem cells through Wnt/beta-catenin signaling for spinal cord injury repair.	Paclitaxel	42-52	catenin beta 1	Rattus norvegicus	129-141
30153562-11	2018	Moreover, mRNA-Seq and western blotting results revealed that PTX-triggered neuronal differentiation occurred through Wnt/beta-catenin signaling pathway.	Paclitaxel	62-65	catenin beta 1	Rattus norvegicus	122-134
30099167-8	2018	Our results revealed that the function and the ultra-structure of BTB in all the fluoride treated groups were damaged with a concomitant significant decreases in basal ectoplasmic specialization (basal ES), associated protein beta-catenin, and F-actin.	Fluorides	81-89	catenin beta 1	Rattus norvegicus	226-238
30060293-0	2018	Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/beta-Catenin Signaling Pathway.	Taurine	25-32	catenin beta 1	Rattus norvegicus	117-129
30060293-0	2018	Cytoprotective Effect of Taurine against Hydrogen Peroxide-Induced Oxidative Stress in UMR-106 Cells through the Wnt/beta-Catenin Signaling Pathway.	Hydrogen Peroxide	41-58	catenin beta 1	Rattus norvegicus	117-129
30060293-7	2018	The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H2O2-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and beta-catenin and activated ERK phosphorylation.	Taurine	40-47	catenin beta 1	Rattus norvegicus	290-302
30060293-7	2018	The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H2O2-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and beta-catenin and activated ERK phosphorylation.	Taurine	158-165	catenin beta 1	Rattus norvegicus	290-302
30060293-7	2018	The results showed that pretreatment of taurine could reverse the inhibition of cell viability and suppress the induced apoptosis in a dose-dependent manner: taurine significantly reduced H2O2-induced oxidative damage and expression of CHOP, while it induced protein expression of Nrf2 and beta-catenin and activated ERK phosphorylation.	Hydrogen Peroxide	188-192	catenin beta 1	Rattus norvegicus	290-302
30060293-10	2018	These data demonstrated that taurine protects osteoblast cells against oxidative damage via Wnt/beta-catenin-mediated activation of the ERK signaling pathway.	Taurine	29-36	catenin beta 1	Rattus norvegicus	96-108
30136620-9	2018	In the caudate putamen, olanzapine increased beta-catenin phosphorylation; and aripiprazole and olanzapine elevated gamma-aminobutyric acid A receptor levels.	Olanzapine	24-34	catenin beta 1	Rattus norvegicus	45-57
30106129-8	2018	Furthermore, osteoblast differentiation ability and Wnt/beta-catenin pathway activity were significantly decreased in Nkd2-silenced rDFSCs compared with the si-NC group (P&lt;0.05 and P&lt;0.001, respectively).	Silicon	91-93	catenin beta 1	Rattus norvegicus	56-68
29932242-0	2018	Involvement of GSK3/beta-catenin in the action of extracellular ATP on differentiation of primary cultures from rat calvaria into osteoblasts.	Adenosine Triphosphate	64-67	catenin beta 1	Rattus norvegicus	20-32
29932242-2	2018	In this study, we investigated the involvement of the GSK3/betacatenin signaling in the action of ATPgamma-S on osteogenic differentiation of primary cell cultures from rat calvaria.	adenosine 5'-O-(3-thiotriphosphate)	98-108	catenin beta 1	Rattus norvegicus	59-70
29932242-3	2018	Our results indicate that the cell treatment with 10 or 100 microM ATPgamma-S for 96 h increase the cytoplasmic levels of beta-catenin and its translocation to nucleus respect to control.	adenosine 5'-O-(3-thiotriphosphate)	67-77	catenin beta 1	Rattus norvegicus	122-134
30221712-5	2018	Celastrol inhibited prostaglandin E2 and caspase-3 protein expression levels, and induced phosphoinositol 3-kinase (PI3K), phosphorylated-protein kinase B (AKT) and glycogen synthase kinase-3 phosphorylation, Wnt and beta-catenin protein expression in GIOP rats.	celastrol	0-9	catenin beta 1	Rattus norvegicus	217-229
29985239-13	2018	Junctional localization of zonula occludens-1 and beta-catenin showed retained integrity in quetiapine-treated cells as compared with the chitosan group in rat BMECs.	Quetiapine Fumarate	92-102	catenin beta 1	Rattus norvegicus	50-62
30533462-2	2018	PBDE-induced hepatocellular tumors harbored Hras and Ctnnb1 mutations and the methods for these studies are provided.	pentabromodiphenyl ether	0-4	catenin beta 1	Rattus norvegicus	53-59
29987974-2	2018	In this study, we proposed a prevailing hypothesis that GSK-3beta inhibitor-mediated activation of GSK-3beta/beta-catenin signaling pathway provides additional cardioprotection in sevoflurane preconditioned rats following I/R injury.	Sevoflurane	180-191	catenin beta 1	Rattus norvegicus	109-121
30214530-7	2018	Besides, activation of Wnt/beta-catenin signaling pathway was observed in rats with CCI.	CCI	84-87	catenin beta 1	Rattus norvegicus	27-39
29987974-6	2018	CONCLUSIONS: Taken together, the findings obtained from the study support the concept that sevoflurane preconditioning confers cardioprotection against myocardial I/R injury and GSK-3beta/beta-catenin signaling activation mediated by TDZD-8 as a novel target to prolong cardioprotection by sevoflurane anaesthesia.	4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione	234-240	catenin beta 1	Rattus norvegicus	188-200
29987974-6	2018	CONCLUSIONS: Taken together, the findings obtained from the study support the concept that sevoflurane preconditioning confers cardioprotection against myocardial I/R injury and GSK-3beta/beta-catenin signaling activation mediated by TDZD-8 as a novel target to prolong cardioprotection by sevoflurane anaesthesia.	Sevoflurane	290-301	catenin beta 1	Rattus norvegicus	188-200
30233727-7	2018	In addition, weight-bearing running enhanced the STZ-induced Wnt and beta-catenin expression levels and reduced the STZ-induced glycogen synthase kinase (GSK)-3beta expression in diabetic rats" femora.	Streptozocin	49-52	catenin beta 1	Rattus norvegicus	69-81
30233727-8	2018	In conclusion, the results suggested that weight-bearing running could partially ameliorate STZ-induced femur atrophy via MSTN downregulation, and this may be associated with the inactivation of Activin A Receptor Type 2B/Smad2/3 signaling pathways and the activation of the Wnt/GSK3beta/beta-catenin signaling pathway.	Streptozocin	92-95	catenin beta 1	Rattus norvegicus	288-300
30119032-0	2018	Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/beta-catenin and MAPK signal pathways suppression.	polygalacic acid	0-16	catenin beta 1	Rattus norvegicus	69-81
30119032-10	2018	To investigate the underlying mechanism, we found that polygalacic acid suppressed both the IL-1beta-induced activation of Wnt/beta-catenin and the mitogen-activated protein kinase (MAPK) signal pathway in chondrocytes.	polygalacic acid	55-71	catenin beta 1	Rattus norvegicus	127-139
30066892-0	2018	Icariin promotes the proliferation and differentiation of osteoblasts from the rat mandible by the Wnt/beta-catenin signalling pathway.	icariin	0-7	catenin beta 1	Rattus norvegicus	103-115
29717341-10	2018	Then we detected the PPAR-gamma and beta-catenin variation when applied with autophagy inhibitor CQ (chloroquine) and the same way, after Akt selective inhibitor applied in the test, the effect of SrRN was compromised.	Chloroquine	97-99	catenin beta 1	Rattus norvegicus	36-48
29717341-10	2018	Then we detected the PPAR-gamma and beta-catenin variation when applied with autophagy inhibitor CQ (chloroquine) and the same way, after Akt selective inhibitor applied in the test, the effect of SrRN was compromised.	Chloroquine	101-112	catenin beta 1	Rattus norvegicus	36-48
30271082-0	2018	Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/beta-catenin signalling pathway.	Vitamin D	29-38	catenin beta 1	Rattus norvegicus	99-111
30271082-0	2018	Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/beta-catenin signalling pathway.	puerarin	43-51	catenin beta 1	Rattus norvegicus	99-111
30099050-4	2018	The results show intrahippocampal injection of OUA 10 nM to activate the Wnt/beta-Catenin signaling pathway and to increase CREB/BDNF and NFKB levels.	Ouabain	47-50	catenin beta 1	Rattus norvegicus	77-89
30271343-0	2018	Protective Effects of Total Glycoside From Rehmannia glutinosa Leaves on Diabetic Nephropathy Rats via Regulating the Metabolic Profiling and Modulating the TGF-beta1 and Wnt/beta-Catenin Signaling Pathway.	Glycosides	28-37	catenin beta 1	Rattus norvegicus	175-187
30271343-11	2018	Furthermore, TLR and DTG prevent high glucose-induced glomerular mesangial cells (GMCs) by inhibiting TGF-beta1 and Wnt/beta-catenin signaling pathway, providing a powerful supports to develop a new therapeutic agent for DN.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	21-24	catenin beta 1	Rattus norvegicus	120-132
30271343-11	2018	Furthermore, TLR and DTG prevent high glucose-induced glomerular mesangial cells (GMCs) by inhibiting TGF-beta1 and Wnt/beta-catenin signaling pathway, providing a powerful supports to develop a new therapeutic agent for DN.	Glucose	38-45	catenin beta 1	Rattus norvegicus	120-132
29999212-3	2018	The chemopreventive effects of SL with both EGCG and KMP were demonstrated by a decrease in thiobaribituric acid reactive substances level, tissue nitric oxide (NO), serum, and tissue beta-catenin as well as a reduction in the multiplicity of aberrant crypt foci (ACF) with alleviation in the dysplastic changes that resulted from DMH administration.	epigallocatechin gallate	44-48	catenin beta 1	Rattus norvegicus	184-196
30208636-2	2018	This study investigated whether EBR-84 protects retinas by inhibiting the beta-catenin pathway using a rat model of retinopathy and a retinal ganglion cell 5 (RGC-5) cell death model.	ebr-84	32-38	catenin beta 1	Rattus norvegicus	74-86
30208636-3	2018	RGC death was induced by either N-methyl-d-aspartic acid (NMDA) or TWS119 (an activator of the beta-catenin pathway).	TWS 119	67-73	catenin beta 1	Rattus norvegicus	95-107
30208636-5	2018	beta-Catenin accumulated in the retinal ganglion cell layer (GCL) of NMDA-treated rats.	N-Methylaspartate	69-73	catenin beta 1	Rattus norvegicus	0-12
30066892-7	2018	Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible.	icariin	13-16	catenin beta 1	Rattus norvegicus	56-68
30066892-7	2018	Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible.	icariin	13-16	catenin beta 1	Rattus norvegicus	209-221
30066892-7	2018	Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible.	icariin	13-16	catenin beta 1	Rattus norvegicus	209-221
30066892-7	2018	Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible.	icariin	323-326	catenin beta 1	Rattus norvegicus	209-221
30066892-7	2018	Furthermore, ICA elevated the mRNA expression levels of beta-catenin, runt-related transcription factor 2, cyclin D1 and alkaline phosphatase in osteoblastic cells, and these effects were inhibited by the Wnt/beta-catenin pathway inhibitor Dickkopf-1; thus, the Wnt/beta-catenin signalling pathway may be involved with the ICA-induced proliferation and differentiation of osteoblasts from the rat mandible.	icariin	323-326	catenin beta 1	Rattus norvegicus	209-221
30066892-8	2018	In conclusion, these results support the osteogenic effects of ICA (0.15 to 15 microM) on osteoblastic cells from the rat mandible and the participation of the Wnt/beta-catenin signalling pathway.	icariin	63-66	catenin beta 1	Rattus norvegicus	164-176
30071471-7	2018	In addition, the levels of gut adherent junction (AJ) proteins (e.g., beta-catenin and E-cadherin) and desmosome plakoglobin along with associated protein alpha-tubulin were clearly decreased in binge alcohol-exposed rats but restored to basal levels in POM-pretreated rats.	Alcohols	201-208	catenin beta 1	Rattus norvegicus	70-82
29436118-9	2018	The inhibitory effects of CST on ALP activity, calcium deposition and beta-catenin protein were abolished by pretreatment with lithium chloride, a GSK3beta inhibitor.	Lithium Chloride	127-143	catenin beta 1	Rattus norvegicus	70-82
30121576-9	2018	GBH treatment decreased membranous and cytoplasmic expression of beta-catenin in luminal and glandular epithelial cells and increased WNT7A expression in the luminal epithelium.	gbh	0-3	catenin beta 1	Rattus norvegicus	65-77
30123297-0	2018	Loureirin B inhibits the proliferation of hepatic stellate cells and the Wnt/beta-catenin signaling pathway by regulating miR-148-3p.	loureirin B	0-11	catenin beta 1	Rattus norvegicus	77-89
30123297-7	2018	Western blot analysis showed that the expressions of Wnt1 and beta-catenin were obviously lower in the loureirin B treatment group than in the control group.	loureirin B	103-114	catenin beta 1	Rattus norvegicus	62-74
30123297-10	2018	Conclusion: Our results suggest that loureirin B inhibited the proliferation and promoted the apoptosis of HSCs, and suppressed the Wnt/beta-catenin signaling pathway via regulation of miR-148-3p.	loureirin B	37-48	catenin beta 1	Rattus norvegicus	136-148
29901112-1	2018	Our previous study indicated that loureirin A induces hair follicle stem cell (HFSC) differentiation through Wnt/beta-catenin signaling pathway activation.	loureirin A	34-45	catenin beta 1	Rattus norvegicus	113-125
29901112-12	2018	Taken together, these results suggest that miR-339-5p negatively regulated loureirin A-induced HFSC differentiation by targeting DLX5, resulting in Wnt/beta-catenin signaling pathway inhibition.	mir-339-5p	43-53	catenin beta 1	Rattus norvegicus	152-164
29901112-12	2018	Taken together, these results suggest that miR-339-5p negatively regulated loureirin A-induced HFSC differentiation by targeting DLX5, resulting in Wnt/beta-catenin signaling pathway inhibition.	loureirin A	75-86	catenin beta 1	Rattus norvegicus	152-164
29775701-7	2018	Our results showed lithium alone posttreatment activated GSK-3beta, therefore increasing active beta-catenin and claudin-1 and claudin-3 expressions, which were accompanied with improved BBB integrity and ameliorated sensorimotor deficits and brain edema in ICH animals.	Lithium	19-26	catenin beta 1	Rattus norvegicus	96-108
29775701-8	2018	We concluded that lithium alone reduced BBB damage after ICH, likely through regulating Akt/GSK-3beta pathway and stabilizing beta-catenin.	Lithium	18-25	catenin beta 1	Rattus norvegicus	126-138
30075015-3	2018	ICG-001 is a small molecule Wnt inhibitor that specifically targets the coactivator CREB binding protein (CBP)/beta-catenin-mediated signalling.	Indocyanine Green	0-3	catenin beta 1	Rattus norvegicus	111-123
30028031-7	2018	The blockade of IGF-IR with AG1024 increased BMSC proliferation and reversed IGFBP-4-induced proliferation inhibition; however, blocking of beta-catenin with FH535 did not.	FH535	158-163	catenin beta 1	Rattus norvegicus	140-152
29715453-9	2018	The current study pledges a promising and novel reno-protective role of the administration of Vit D and pioglitazone entailing a potential involvement of ICAM-1, MPO, NF-kappaB, Ang II, ACE2, TGFbeta, and a modulation of Wnt4/beta-catenin pathway.	Pioglitazone	104-116	catenin beta 1	Rattus norvegicus	226-238
28605990-13	2018	CONCLUSIONS: miR-25 protects PC-12 cells against H2O2-induced oxidative damage though regulation of Nrf2 and activation of Wnt/beta-catenin and PI3 K/AKT/ERK signaling.	PC 12 ester	29-34	catenin beta 1	Rattus norvegicus	127-139
29568900-0	2018	Glucosamine promotes chondrocyte proliferation via the Wnt/beta-catenin signaling pathway.	Glucosamine	0-11	catenin beta 1	Rattus norvegicus	59-71
29568900-5	2018	Furthermore, GlcN upregulated the expression levels of Wnt-4, Frizzled-2 and beta-catenin, and downregulated the expression of glycogen synthase kinase-3.	Glucosamine	13-17	catenin beta 1	Rattus norvegicus	77-89
29568900-6	2018	GlcN also promoted beta-catenin translocation; beta-catenin is able to activate numerous downstream target genes, including cyclin D1.	Glucosamine	0-4	catenin beta 1	Rattus norvegicus	19-31
29568900-6	2018	GlcN also promoted beta-catenin translocation; beta-catenin is able to activate numerous downstream target genes, including cyclin D1.	Glucosamine	0-4	catenin beta 1	Rattus norvegicus	47-59
28605990-0	2018	MiR-25 protects PC-12 cells from H2O2 mediated oxidative damage via WNT/beta-catenin pathway.	PC 12 ester	16-21	catenin beta 1	Rattus norvegicus	72-84
28605990-0	2018	MiR-25 protects PC-12 cells from H2O2 mediated oxidative damage via WNT/beta-catenin pathway.	Hydrogen Peroxide	33-37	catenin beta 1	Rattus norvegicus	72-84
28605990-13	2018	CONCLUSIONS: miR-25 protects PC-12 cells against H2O2-induced oxidative damage though regulation of Nrf2 and activation of Wnt/beta-catenin and PI3 K/AKT/ERK signaling.	Hydrogen Peroxide	49-53	catenin beta 1	Rattus norvegicus	127-139
29204817-0	2018	Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/beta-catenin signaling pathway.	Oxyphenbutazone	0-15	catenin beta 1	Rattus norvegicus	109-121
29204817-14	2018	As evident COX-2 catalyzes the synthesis of PGE2, needed in the activation of Wnt/beta-catenin pathway, which in turn is responsible for activating the transcriptional proteins required for higher degree of cell division and thence growth.	Dinoprostone	44-48	catenin beta 1	Rattus norvegicus	82-94
29729281-0	2018	Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of beta-catenin nuclear accumulation by restoring SIRT1 in rats.	salvianolic acid A	0-18	catenin beta 1	Rattus norvegicus	84-96
29729281-0	2018	Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of beta-catenin nuclear accumulation by restoring SIRT1 in rats.	Ethanol	38-45	catenin beta 1	Rattus norvegicus	84-96
29729281-8	2018	Importantly, we found that SalA treatment effectively inhibited the ethanol-mediated decrease in nuclear beta-catenin by upregulating SIRT1 in the liver.	salvianolic acid A	27-31	catenin beta 1	Rattus norvegicus	105-117
29729281-8	2018	Importantly, we found that SalA treatment effectively inhibited the ethanol-mediated decrease in nuclear beta-catenin by upregulating SIRT1 in the liver.	Ethanol	68-75	catenin beta 1	Rattus norvegicus	105-117
29729281-9	2018	SIRT1 then deacetylated beta-catenin to promote its accumulation in the nucleus, thereby preventing alcohol-induced liver injury.	Alcohols	100-107	catenin beta 1	Rattus norvegicus	24-36
29729281-10	2018	The results demonstrate that the SIRT1/beta-catenin pathway is a key therapeutic target in liver injury caused by chronic alcohol exposure and that SalA protects against alcohol-induced liver injury via the SIRT1-mediated deacetylation of beta-catenin.	salvianolic acid A	148-152	catenin beta 1	Rattus norvegicus	239-251
29729281-10	2018	The results demonstrate that the SIRT1/beta-catenin pathway is a key therapeutic target in liver injury caused by chronic alcohol exposure and that SalA protects against alcohol-induced liver injury via the SIRT1-mediated deacetylation of beta-catenin.	Alcohols	170-177	catenin beta 1	Rattus norvegicus	239-251
29248448-13	2018	CONCLUSIONS: The present results demonstrate that ZWT extract ameliorates adenine-induced CRF in rats by regulation of the canonical Wnt4/beta-catenin signaling in the kidneys.	Adenine	74-81	catenin beta 1	Rattus norvegicus	138-150
29961297-16	2018	(3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P&lt;0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P&lt;0.05).	Lithium Chloride	72-88	catenin beta 1	Rattus norvegicus	48-60
29961297-16	2018	(3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P&lt;0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P&lt;0.05).	Lithium Chloride	72-88	catenin beta 1	Rattus norvegicus	256-268
29961297-16	2018	(3) On PSD 14, the mRNA expressions of Wnt1 and beta-catenin of rats in lithium chloride group and alprostadil group were significantly higher than those in simple scald group (q=65.40, 19.16, 66.79, 18.41, P&lt;0.05), and the mRNA expressions of Wnt1 and beta-catenin of rats in simple scald group was significantly higher than those in sham scald group (t=14.86, 4.46, P&lt;0.05).	Alprostadil	99-110	catenin beta 1	Rattus norvegicus	256-268
29961297-19	2018	Conclusions: Alprostadil can accelerate wound healing through activating Wnt/beta-catenin signal pathway and upregulating the expressions of Wnt1 and beta-catenin.	Alprostadil	13-24	catenin beta 1	Rattus norvegicus	77-89
29961297-19	2018	Conclusions: Alprostadil can accelerate wound healing through activating Wnt/beta-catenin signal pathway and upregulating the expressions of Wnt1 and beta-catenin.	Alprostadil	13-24	catenin beta 1	Rattus norvegicus	150-162
29106746-2	2018	Lithium, commonly used in psychiatric medicine, inhibits glycogen synthase kinase-3beta in the Wnt/beta-catenin pathway, leading to up-regulation of osteogenesis.	Lithium	0-7	catenin beta 1	Rattus norvegicus	99-111
29603556-0	2018	Caffeic acid phenethyl ester guards against benign prostate hypertrophy in rats: Role of IGF-1R/protein kinase-B (Akt)/beta-catenin signaling.	caffeic acid phenethyl ester	0-28	catenin beta 1	Rattus norvegicus	119-131
29536658-0	2018	MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/beta-catenin signalling pathway.	microrna-140-5p	0-15	catenin beta 1	Rattus norvegicus	115-127
29536658-0	2018	MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/beta-catenin signalling pathway.	Dexmedetomidine	48-63	catenin beta 1	Rattus norvegicus	115-127
29536658-3	2018	This study was to investigate the role by which miR-140-5p provides cerebral protection using DEX to treat hypoxic-ischaemic brain damage (HIBD) in neonatal rats via the Wnt/beta-catenin signalling pathway.	mir-140-5p	48-58	catenin beta 1	Rattus norvegicus	174-186
29536658-11	2018	Our study demonstrates that miR-140-5p promotes the cerebral protective effects of DEX against HIBD in neonatal rats by targeting the Wnt1 gene through via the negative regulation of the Wnt/beta-catenin signalling pathway.	mir-140-5p	28-38	catenin beta 1	Rattus norvegicus	191-203
29536658-11	2018	Our study demonstrates that miR-140-5p promotes the cerebral protective effects of DEX against HIBD in neonatal rats by targeting the Wnt1 gene through via the negative regulation of the Wnt/beta-catenin signalling pathway.	Dexmedetomidine	83-86	catenin beta 1	Rattus norvegicus	191-203
29501527-9	2018	We also found that retigabine alleviated acute stress-induced spatial memory retrieval impairment through adjusting the aberrance of USP2, its upstream regulators (PGC-1alpha, E4BP4 and beta-catenin) and its downstream targets (mTOR, autophagy and GluA1).	ezogabine	19-29	catenin beta 1	Rattus norvegicus	186-198
29110214-7	2018	To address the mechanism triggering downregulation of miR-223 under PE, we demonstrated that PE-induced inhibition of GSK-3beta activity led to the activation of beta-catenin, which initiates the transcription of SOX2.	Phenylephrine	68-70	catenin beta 1	Rattus norvegicus	162-174
29603556-7	2018	In addition, co-treatment with CAPE significantly suppressed insulin-like growth factor-1 receptor (IGF-1R)/Akt/beta-catenin/cyclinD1 axis as well as tumor necrosis factor-alpha level and nuclear factor (NF)-kB activity.	caffeic acid phenethyl ester	31-35	catenin beta 1	Rattus norvegicus	112-124
29486057-1	2018	BACKGROUND AND PURPOSE: The anti-helminthic drug niclosamide regulates multiple cellular signals including STAT3, AMP-activated protein kinase (AMPK), Akt, Wnt/beta-catenin and mitochondrial uncoupling which are involved in neointimal hyperplasia.	Niclosamide	49-60	catenin beta 1	Rattus norvegicus	160-172
29447955-9	2018	Expression of Wnt/beta-catenin was up-regulated in both in vitro osteocytes treated with high dose of fluoride and bone tissue of rats in the presence of fluoride and PTH.	Fluorides	102-110	catenin beta 1	Rattus norvegicus	18-30
29447955-9	2018	Expression of Wnt/beta-catenin was up-regulated in both in vitro osteocytes treated with high dose of fluoride and bone tissue of rats in the presence of fluoride and PTH.	Fluorides	154-162	catenin beta 1	Rattus norvegicus	18-30
29752762-8	2018	The effect of feeding was mimicked by administration of the GLP-1 agonist exendin-4, and was characterized by cAMP-dependent phosphorylation of beta-catenin at serine residues 552 and 675.	Cyclic AMP	110-114	catenin beta 1	Rattus norvegicus	144-156
29752762-8	2018	The effect of feeding was mimicked by administration of the GLP-1 agonist exendin-4, and was characterized by cAMP-dependent phosphorylation of beta-catenin at serine residues 552 and 675.	Serine	160-166	catenin beta 1	Rattus norvegicus	144-156
29752762-9	2018	The data suggest that beta-catenin/TCF signalling is involved in metabolic sensing in the hypothalamus.	tcf	35-38	catenin beta 1	Rattus norvegicus	22-34
29561031-0	2018	Enhanced osteogenic differentiation and bone regeneration of poly(lactic-co-glycolic acid) by graphene via activation of PI3K/Akt/GSK-3beta/beta-catenin signal circuit.	Polylactic Acid-Polyglycolic Acid Copolymer	61-90	catenin beta 1	Rattus norvegicus	140-152
29561031-0	2018	Enhanced osteogenic differentiation and bone regeneration of poly(lactic-co-glycolic acid) by graphene via activation of PI3K/Akt/GSK-3beta/beta-catenin signal circuit.	Graphite	94-102	catenin beta 1	Rattus norvegicus	140-152
29561031-7	2018	Moreover, the incorporation of graphene might activate the PI3K/Akt/GSK-3beta/beta-catenin signaling pathway, which appeared to be the mechanism behind the osteoinductive properties of graphene.	Graphite	31-39	catenin beta 1	Rattus norvegicus	78-90
29561031-7	2018	Moreover, the incorporation of graphene might activate the PI3K/Akt/GSK-3beta/beta-catenin signaling pathway, which appeared to be the mechanism behind the osteoinductive properties of graphene.	Graphite	185-193	catenin beta 1	Rattus norvegicus	78-90
29643535-8	2018	Then, the up-regulation of beta-catenin, Fn and SMA was attenuated by pre-treatment of Tet, and the result also displayed that the difference was statistically significant, and the P values were 0.009, 0.005, 0.019,respectively.	tet	87-90	catenin beta 1	Rattus norvegicus	27-39
29771446-0	2018	Simvastatin induces osteogenic differentiation of MSCs via Wnt/beta-catenin pathway to promote fracture healing.	Simvastatin	0-11	catenin beta 1	Rattus norvegicus	63-75
29771446-1	2018	OBJECTIVE: This study was designed to investigate whether Simvastatin could facilitate osteogenic differentiation of rat marrow mesenchymal stem cells (MSCs) by modulating the Wnt/beta-catenin pathway, thus promoting fracture healing.	Simvastatin	58-69	catenin beta 1	Rattus norvegicus	180-192
29771446-10	2018	Simvastatin markedly up-regulated the expression of the beta-catenin protein, while transfection of beta-catenin shRNA inhibited the expression of osteoblast-related genes including ALP, Runx2, OCN, and OPN.	Simvastatin	0-11	catenin beta 1	Rattus norvegicus	56-68
29771446-11	2018	CONCLUSIONS: Simvastatin can promote the differentiation of rat MSCs into osteoblast-like cells, and its mechanism may be related to the Wnt/beta-catenin pathway.	Simvastatin	13-24	catenin beta 1	Rattus norvegicus	141-153
31938361-0	2018	Effects of melatonin on diabetic nephropathy rats via Wnt/beta-catenin signaling pathway and TGF-beta-Smad signaling pathway.	Melatonin	11-20	catenin beta 1	Rattus norvegicus	58-70
31938361-13	2018	When melatonin was given, the expression of Wnt4 and beta-catenin in the medium dose group and the high dose group were significantly lower than the model group.	Melatonin	5-14	catenin beta 1	Rattus norvegicus	53-65
31938361-15	2018	CONCLUSIONS: Melatonin improves renal function, relieves oxidative stress, and protects the renal tissue via the Wnt/beta-catenin signaling pathway and the TGF-beta1-Smad2/3 signaling pathway in STZ-induced DN rats.	Melatonin	13-22	catenin beta 1	Rattus norvegicus	117-129
29921370-9	2018	Soy isoflavones can reduce 24-h urinary protein quantification, alleviate renal interstitial pathological damage, and regulate the expression of Wnt4, beta-catenin and TGF-beta1 in the renal interstitium.	Isoflavones	4-15	catenin beta 1	Rattus norvegicus	151-163
29921370-10	2018	This suggests that soybean isoflavones could delay the process of renal interstitial fibrosis in DN rats by decreasing the expression of Wnt4, beta-catenin and TGF-beta1 in the renal interstitium, thus demonstrating that soybean isoflavones plus losartan have the best protective effects against diabetes-induced renal fibrosis.	Isoflavones	27-38	catenin beta 1	Rattus norvegicus	143-155
31149252-1	2018	Background: This study aimed to assess the mechanism through which Wnt/ beta - catenin signaling pathway, and StarD7, prometes testosterone synthesis, and to explore a new pathway for the regulation of testosterone synthesis.	Testosterone	127-139	catenin beta 1	Rattus norvegicus	72-86
31149252-1	2018	Background: This study aimed to assess the mechanism through which Wnt/ beta - catenin signaling pathway, and StarD7, prometes testosterone synthesis, and to explore a new pathway for the regulation of testosterone synthesis.	Testosterone	202-214	catenin beta 1	Rattus norvegicus	72-86
31149252-6	2018	These findings indicate a possible role of StarD7 and beta-catenin in the process of annexin5-mediated stimulation of testosterone synthesis.	Testosterone	118-130	catenin beta 1	Rattus norvegicus	54-66
31149252-7	2018	Conclusions: Wnt/beta-catenin signaling pathway and StarD7 are involved in the process of annexin5 stimulation of testosterone synthesis.	Testosterone	114-126	catenin beta 1	Rattus norvegicus	17-29
31149252-8	2018	Activation of Wnt/ beta-catenin signaling pathway by Annexin5, and increase in StarD7 expression lead to elevated expression of key regulatory enzymes in testosterone synthesis, thus promoting testosterone synthesis.	Testosterone	154-166	catenin beta 1	Rattus norvegicus	19-31
31149252-8	2018	Activation of Wnt/ beta-catenin signaling pathway by Annexin5, and increase in StarD7 expression lead to elevated expression of key regulatory enzymes in testosterone synthesis, thus promoting testosterone synthesis.	Testosterone	193-205	catenin beta 1	Rattus norvegicus	19-31
29538301-11	2018	Moreover, l-Car significantly reduced PTZ-induced elevation in protein expression of caspase-3 (p &lt; 0.0001) and beta-catenin (p &lt; 0.0001).	Carnitine	10-15	catenin beta 1	Rattus norvegicus	115-127
29410165-9	2018	Our results suggest that sevoflurane exposure during the second trimester inhibits fetal NSC proliferation via the Wnt/beta-catenin pathway and impairs postnatal learning and memory function in a dose-dependent manner.	Sevoflurane	25-36	catenin beta 1	Rattus norvegicus	119-131
29538301-11	2018	Moreover, l-Car significantly reduced PTZ-induced elevation in protein expression of caspase-3 (p &lt; 0.0001) and beta-catenin (p &lt; 0.0001).	Pentylenetetrazole	38-41	catenin beta 1	Rattus norvegicus	115-127
29692859-6	2018	Moreover, UroA reduced the protein expressions of phosphor-Akt (Thr308) and beta-catenin in a high glucose-induced A7r5 vascular smooth muscle cell proliferation model.	Glucose	99-106	catenin beta 1	Rattus norvegicus	76-88
29693006-0	2018	Baicalein Accelerates Tendon-Bone Healing via Activation of Wnt/beta-Catenin Signaling Pathway in Rats.	baicalein	0-9	catenin beta 1	Rattus norvegicus	64-76
29693006-9	2018	Conclusion: These data suggest that baicalein may stimulate TDSCs osteogenic differentiation via activation of Wnt/beta-catenin signaling pathway to accelerate tendon-bone healing.	baicalein	36-45	catenin beta 1	Rattus norvegicus	115-127
29331760-0	2018	Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of beta-catenin signaling.	inotodiol	0-9	catenin beta 1	Rattus norvegicus	115-127
29331760-13	2018	Conclusively, results suggest that inotodiol regulates blood glucose levels in diabetic rats and then controls proliferation of breast tumor progression by inducing apoptosis via downregulation of beta-catenin signaling.	inotodiol	35-44	catenin beta 1	Rattus norvegicus	197-209
29504097-1	2018	Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical beta-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development.	DDT	72-103	catenin beta 1	Rattus norvegicus	155-167
29353207-6	2018	Geraniin enhanced the expression of beta-catenin, frizzled2, LRP6, TCF4, LEF1, c-myc, cyclin D1, Runx2 and osterix, while inhibited the expression of axin2 (P &lt; 0.05).	Geraniin	0-8	catenin beta 1	Rattus norvegicus	36-48
29353207-7	2018	Wnt inhibitor significantly weakened geraniin-induced Wnt/beta-catenin activation (P &lt; 0.05).	Geraniin	37-45	catenin beta 1	Rattus norvegicus	58-70
29353207-8	2018	In conclusion, geraniin enhances the activation of Wnt/beta-catenin pathway, which may explain how it promotes osteoblast proliferation and differentiation.	Geraniin	15-23	catenin beta 1	Rattus norvegicus	55-67
29504097-1	2018	Prenatal and postnatal exposure to low doses of the endocrine disruptor dichlorodiphenyltrichloroethane (DDT) leads to delayed activation of the canonical beta-catenin/Wnt signaling in zona glomerulosa and zona reticularis of the adrenal cortex in rats, which changed the rate of their postnatal development.	DDT	105-108	catenin beta 1	Rattus norvegicus	155-167
29461613-5	2018	Phenotypically, PQ induced-EMT was characterized by loss of epithelial cell markers including E-cadherin, while upregulation of mesenchymal cell markers including vimentin, was concurrent with the activation of Wnt/beta-catenin signaling pathway.	Paraquat	16-18	catenin beta 1	Rattus norvegicus	215-227
29467842-13	2018	HIF-1alpha may regulate PQ-induced EMT through the LOX/beta-catenin pathway.	Paraquat	24-26	catenin beta 1	Rattus norvegicus	55-67
29251361-2	2018	The aim of the study was to determine whether PEMF can successfully improve subchondral bone microstructure through a Wnt/beta-catenin signaling-associated pathway in rats with knee OA induced by low-dose monosodium iodoacetate (MIA).	pemf	46-50	catenin beta 1	Rattus norvegicus	122-134
29427793-0	2018	Peroxynitrite enhances self-renewal, proliferation and neuronal differentiation of neural stem/progenitor cells through activating HIF-1alpha and Wnt/beta-catenin signaling pathway.	Peroxynitrous Acid	0-13	catenin beta 1	Rattus norvegicus	150-162
29427793-8	2018	Furthermore, the neurogenesis-promoting effects of peroxynitrite were partly through activating HIF-1alpha correlated with enhanced Wnt/beta-catenin signaling pathway.	Peroxynitrous Acid	51-64	catenin beta 1	Rattus norvegicus	136-148
29461613-6	2018	Furthermore, knockdown of beta-catenin by using specific siRNA could reverse PQ triggered EMT process and attenuated cell migration ability.	Paraquat	77-79	catenin beta 1	Rattus norvegicus	26-38
29377229-9	2018	Our findings demonstrate that miR-129-5p improves the neuroprotective role of DEX in HIBI by targeting COL3A1 through the Wnt/beta-catenin signaling pathway in neonatal rats.	Dexmedetomidine	78-81	catenin beta 1	Rattus norvegicus	126-138
28185129-6	2018	Furthermore, folic acid in the presence of glutamate insult in hippocampal slices maintained for an additional period of 6 h in fresh culture medium without glutamate and/or folic acid induced phosphorylation of GSK-3beta and beta-catenin expression.	Folic Acid	13-23	catenin beta 1	Rattus norvegicus	226-238
28185129-6	2018	Furthermore, folic acid in the presence of glutamate insult in hippocampal slices maintained for an additional period of 6 h in fresh culture medium without glutamate and/or folic acid induced phosphorylation of GSK-3beta and beta-catenin expression.	Glutamic Acid	43-52	catenin beta 1	Rattus norvegicus	226-238
28185129-8	2018	In conclusion, the results of this study show that the protective effect of folic acid against glutamate-induced excitotoxicity may involve the modulation of PI3K/GSK-3beta/beta-catenin pathway and iNOS inhibition.	Folic Acid	76-86	catenin beta 1	Rattus norvegicus	173-185
28185129-8	2018	In conclusion, the results of this study show that the protective effect of folic acid against glutamate-induced excitotoxicity may involve the modulation of PI3K/GSK-3beta/beta-catenin pathway and iNOS inhibition.	Glutamic Acid	95-104	catenin beta 1	Rattus norvegicus	173-185
29224185-8	2018	However, ICG-001, the beta-catenin selective inhibitor, reversed the positive effects of GSK-3beta inhibition.	Indocyanine Green	9-12	catenin beta 1	Rattus norvegicus	22-34
29377229-0	2018	microRNA-129-5p involved in the neuroprotective effect of dexmedetomidine on hypoxic-ischemic brain injury by targeting COL3A1 through the Wnt/beta-catenin signaling pathway in neonatal rats.	Dexmedetomidine	58-73	catenin beta 1	Rattus norvegicus	143-155
29377229-1	2018	Our study aims to elucidate the mechanisms how microRNA-129-5p (miR-129-5p) involved in the neuroprotective effect of dexmedetomidine (DEX) on hypoxic-ischemic brain injury (HIBI) by targeting the type III procollagen gene (COL3A1) through the Wnt/beta-catenin signaling pathway in neonatal rats.	Dexmedetomidine	118-133	catenin beta 1	Rattus norvegicus	248-260
29439258-12	2018	CONCLUSION: Our findings demonstrated that BMCs have tumor suppressive effects in DMH-induced colon cancer as evidenced by down-regulation of survivin, beta-catenin, and MDR-1 genes and enhancing the antioxidant activity.	1,2-Dimethylhydrazine	82-85	catenin beta 1	Rattus norvegicus	152-164
29377229-1	2018	Our study aims to elucidate the mechanisms how microRNA-129-5p (miR-129-5p) involved in the neuroprotective effect of dexmedetomidine (DEX) on hypoxic-ischemic brain injury (HIBI) by targeting the type III procollagen gene (COL3A1) through the Wnt/beta-catenin signaling pathway in neonatal rats.	Dexmedetomidine	135-138	catenin beta 1	Rattus norvegicus	248-260
30205381-0	2018	Berberine Exerts a Protective Effect on Gut-Vascular Barrier via the Modulation of the Wnt/Beta-Catenin Signaling Pathway During Sepsis.	Berberine	0-9	catenin beta 1	Rattus norvegicus	91-103
30205381-10	2018	CONCLUSION: Berberine exerted a protective effect on GVB function in sepsis, which was strictly related to the modulation of the Wnt/beta-catenin signaling pathway.	Berberine	12-21	catenin beta 1	Rattus norvegicus	133-145
30415260-0	2018	High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/beta-Catenin Pathway.	Aspirin	22-29	catenin beta 1	Rattus norvegicus	99-111
30415260-6	2018	The aim of our study was to determine whether aspirin induces apoptosis in rat TSCs via the Wnt/beta-catenin pathway.	Aspirin	46-53	catenin beta 1	Rattus norvegicus	96-108
30415260-9	2018	Next, we used western blotting to determine the effect of aspirin on the Wnt/beta-catenin pathway.	Aspirin	58-65	catenin beta 1	Rattus norvegicus	77-89
30415260-11	2018	Finally, we used flow cytometry, fluorescence, and western blotting to investigate the aspirin-induced apoptosis of TSCs via the Wnt/beta-catenin pathway.	Aspirin	87-94	catenin beta 1	Rattus norvegicus	133-145
30415260-16	2018	CONCLUSION: The Wnt/beta-catenin pathway plays a vital role in aspirin-induced apoptosis by regulating mitochondrial/caspase-3 function.	Aspirin	63-70	catenin beta 1	Rattus norvegicus	20-32
29705802-8	2018	Additionally, LiCl treatment increased SOA activity, GSH-Px levels, and GSK-3beta-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GSK-3beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells.	Lithium Chloride	14-18	catenin beta 1	Rattus norvegicus	195-207
29705802-0	2018	Salidroside Protection Against Oxidative Stress Injury Through the Wnt/beta-Catenin Signaling Pathway in Rats with Parkinson"s Disease.	rhodioloside	0-11	catenin beta 1	Rattus norvegicus	71-83
29705802-10	2018	CONCLUSION: Evidence from experimental models suggested that SDS may confer neuroprotection against the neurotoxicity of 6-OHDA in response to OS injury and showed that these beneficial effects may be related to regulation of the Wnt/beta-catenin signaling pathway.	rhodioloside	61-64	catenin beta 1	Rattus norvegicus	234-246
29115514-13	2018	The mechanism underlying the preventive effect of PM for the treatment of GIO may be associated with direct upregulation of the canonical Wnt/beta-catenin signaling pathway.	pipermethystine	50-52	catenin beta 1	Rattus norvegicus	142-154
29115491-10	2018	Resveratrol may improve fibrosis via the suppression of MC activation and TGF-beta/Wnt/beta-catenin pathway activities.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	87-99
29039516-8	2017	Knockdown of beta-catenin expression inhibited H2O2-induced cell apoptosis.	Hydrogen Peroxide	47-51	catenin beta 1	Rattus norvegicus	13-25
29259894-0	2017	Suppression of corneal neovascularization by curcumin via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	45-53	catenin beta 1	Rattus norvegicus	76-88
29259894-1	2017	AIM: To investigate whether curcumin suppressed corneal neovascularization (CNV) formation via inhibiting activation of Wnt/beta-catenin pathway.	Curcumin	28-36	catenin beta 1	Rattus norvegicus	124-136
29259894-9	2017	Curcumin inhibited LRP6 phosphorylation and nuclear accumulation of beta-catenin.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	68-80
29259894-11	2017	Meanwhile curcumin suppressed suture-induced CNV and inhibited LRP6 phosphorylation as well as beta-catenin accumulation in SD rats.	Curcumin	10-18	catenin beta 1	Rattus norvegicus	95-107
29259894-12	2017	CONCLUSION: Taken together, activation of Wnt/beta-catenin pathway could be involved in endothelial proliferation during suture-induced CNV formation and curcumin attenuated CNV formation via inhibition of Wnt/beta-catenin pathway activation.	Curcumin	154-162	catenin beta 1	Rattus norvegicus	210-222
29039516-0	2017	Baicalin alleviates H2O2-induced injury of H9c2 cardiomyocytes through suppression of the Wnt/beta-catenin signaling pathway.	Hydrogen Peroxide	20-24	catenin beta 1	Rattus norvegicus	94-106
29039516-7	2017	Furthermore, baicalin markedly decreased the expression of beta-catenin and downstream Axin-2 and myc proto-oncogene protein in H2O2-treated H9c2 cells.	Hydrogen Peroxide	128-132	catenin beta 1	Rattus norvegicus	59-71
29115610-8	2018	Furthermore, inhibition of the Wnt/beta-catenin pathway with FH535 attenuated the influence of miR-21 overexpression on NSC proliferation, indicating that the factors activated by miR-21 overexpression were inhibited by FH535 treatment.	FH535	61-66	catenin beta 1	Rattus norvegicus	35-47
27682266-7	2018	This may, in part, be mediated by modifying lithium-induced alterations in beta-catenin activity through its effects on GSK-3beta.	Lithium	44-51	catenin beta 1	Rattus norvegicus	75-87
29031619-0	2017	Chemoprevention by artesunate in a preclinical model of colorectal cancer involves down regulation of beta-catenin, suppression of angiogenesis, cellular proliferation and induction of apoptosis.	Artesunate	19-29	catenin beta 1	Rattus norvegicus	102-114
29039516-9	2017	Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin.	Lithium Chloride	9-13	catenin beta 1	Rattus norvegicus	17-29
29039516-9	2017	Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin.	Lithium Chloride	9-13	catenin beta 1	Rattus norvegicus	108-120
29039516-9	2017	Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin.	baicalin	180-188	catenin beta 1	Rattus norvegicus	17-29
29039516-9	2017	Finally, LiCl (a beta-catenin stabilizer) induced apoptosis of H9c2 cells by upregulating the expression of beta-catenin, which was significantly neutralized by the treatment with baicalin.	baicalin	180-188	catenin beta 1	Rattus norvegicus	108-120
28798257-7	2017	Using silencing approaches to reduce beta-catenin levels prevented both hypoxia- and AQP1-induced migration and proliferation of PASMCs, as well as induction of c-Myc and cyclin D1 by AQP1.	pasmcs	129-135	catenin beta 1	Rattus norvegicus	37-49
29031900-13	2017	Resveratrol can improve the dysfunction by downregulating the mast cell activation and the activity of TGF-beta/Wnt/beta-catenin pathway.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	116-128
28870812-9	2017	Beta-catenin and glutamine synthetase, a known target of beta-catenin, were up-regulated in the liver of HN Thx group.	Thyroxine	108-111	catenin beta 1	Rattus norvegicus	0-12
28870812-9	2017	Beta-catenin and glutamine synthetase, a known target of beta-catenin, were up-regulated in the liver of HN Thx group.	Thyroxine	108-111	catenin beta 1	Rattus norvegicus	57-69
28798257-8	2017	Thus our results indicate that elevated AQP1 levels upregulate beta-catenin protein levels, via a mechanism requiring the AQP1 COOH-terminal tail, enhancing expression of beta-catenin targets and promoting PASMC proliferation and migration.	pasmc	206-211	catenin beta 1	Rattus norvegicus	63-75
28949389-0	2017	Psoralen promotes the expression of cyclin D1 in chondrocytes via the Wnt/beta-catenin signaling pathway.	Ficusin	0-8	catenin beta 1	Rattus norvegicus	74-86
28842124-6	2017	Furthermore, systemic administration of phencyclidine, but not methamphetamine, down-regulated mRNA expression of primary cilium morphology-related genes, including kif3a, 5-HTR6, RPGRIP1L, and TMEM67, and of genes composing the cilial Wnt/beta-catenin signaling pathway, beta-catenin, syn2 and Bcl-2, in the hippocampus, but not in the cerebral cortex of rats.	Phencyclidine	40-53	catenin beta 1	Rattus norvegicus	240-252
28842124-6	2017	Furthermore, systemic administration of phencyclidine, but not methamphetamine, down-regulated mRNA expression of primary cilium morphology-related genes, including kif3a, 5-HTR6, RPGRIP1L, and TMEM67, and of genes composing the cilial Wnt/beta-catenin signaling pathway, beta-catenin, syn2 and Bcl-2, in the hippocampus, but not in the cerebral cortex of rats.	Phencyclidine	40-53	catenin beta 1	Rattus norvegicus	272-284
29102300-0	2017	Corrigendum to "1, 25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the beta-catenin/TCF4/GSK-3beta/mTOR pathway" [J.	Calcitriol	16-41	catenin beta 1	Rattus norvegicus	160-172
28849074-0	2017	Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/beta-catenin signaling pathway.	Pioglitazone	10-22	catenin beta 1	Rattus norvegicus	118-130
31966482-0	2017	Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/beta-catenin pathway.	Melatonin	0-9	catenin beta 1	Rattus norvegicus	81-93
31966482-0	2017	Melatonin attenuates phosgene-induced acute lung injury via the upregulation Wnt/beta-catenin pathway.	Phosgene	21-29	catenin beta 1	Rattus norvegicus	81-93
28830684-10	2017	XAV-939, an inhibitor of Wnt/beta-catenin signaling, partially reversed the pro-apoptotic effect of NE.	XAV939	0-7	catenin beta 1	Rattus norvegicus	29-41
29104534-7	2017	In original cultured ischemic NSCs, transfection of MiRNA-148b mimic or inhibitor could suppress or enhance the expression of Wnt-1, beta-catenin, and Cyclin D1, hence effected wnt/beta-catenin signaling.	mirna-148b	52-62	catenin beta 1	Rattus norvegicus	133-145
29104534-7	2017	In original cultured ischemic NSCs, transfection of MiRNA-148b mimic or inhibitor could suppress or enhance the expression of Wnt-1, beta-catenin, and Cyclin D1, hence effected wnt/beta-catenin signaling.	mirna-148b	52-62	catenin beta 1	Rattus norvegicus	181-193
29138567-0	2017	Resveratrol ameliorates chronic unpredictable mild stress-induced depression-like behavior: involvement of the HPA axis, inflammatory markers, BDNF, and Wnt/beta-catenin pathway in rats.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	157-169
28582278-8	2017	Importantly, treatment with Wnt/beta-catenin inhibitor XAV939 partly neutralized ADMSC-ex-induced antiapoptotic and prosurvival effects in H9c2 cells.	XAV939	55-61	catenin beta 1	Rattus norvegicus	32-44
29052243-0	2017	Wnt/beta-catenin signalling pathway mediated aberrant hippocampal neurogenesis in kainic acid-induced epilepsy.	Kainic Acid	82-93	catenin beta 1	Rattus norvegicus	4-16
29052243-6	2017	Immunostaining and western blotting results showed that the expression levels of beta-catenin, Wnt3a, and cyclin D1, the key regulators in Wnt signalling pathway, were up-regulated during acute epilepsy induced by the injection of kainic acids, indicating that Wnt signalling pathway was activated in kainic acid-induced temporal lobe epilepsy.	Kainic Acid	231-243	catenin beta 1	Rattus norvegicus	81-93
29052243-6	2017	Immunostaining and western blotting results showed that the expression levels of beta-catenin, Wnt3a, and cyclin D1, the key regulators in Wnt signalling pathway, were up-regulated during acute epilepsy induced by the injection of kainic acids, indicating that Wnt signalling pathway was activated in kainic acid-induced temporal lobe epilepsy.	Kainic Acid	231-242	catenin beta 1	Rattus norvegicus	81-93
29052243-7	2017	Moreover, BrdU labelling results showed that blockade of the Wnt signalling by knocking down beta-catenin attenuated aberrant neurogenesis induced by kainic acids injection.	Bromodeoxyuridine	10-14	catenin beta 1	Rattus norvegicus	93-105
29052243-7	2017	Moreover, BrdU labelling results showed that blockade of the Wnt signalling by knocking down beta-catenin attenuated aberrant neurogenesis induced by kainic acids injection.	Kainic Acid	150-162	catenin beta 1	Rattus norvegicus	93-105
28582278-8	2017	Importantly, treatment with Wnt/beta-catenin inhibitor XAV939 partly neutralized ADMSC-ex-induced antiapoptotic and prosurvival effects in H9c2 cells.	admsc-ex	81-89	catenin beta 1	Rattus norvegicus	32-44
28929374-0	2017	Inhibition of GSK-3beta Activation Protects SD Rat Retina Against N-Methyl-N-Nitrosourea-Induced Degeneration by Modulating the Wnt/beta-Catenin Signaling Pathway.	Methylnitrosourea	66-88	catenin beta 1	Rattus norvegicus	132-144
29104486-0	2017	Tanshinone IIA Inhibits beta-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis.	tanshinone	0-10	catenin beta 1	Rattus norvegicus	24-36
28780397-5	2017	On PND8, GBH-exposed rats showed increased Wnt5a and beta-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and beta-catenin expression in subepithelial stroma but decreased beta-catenin expression in glandular epithelium.	gbh	9-12	catenin beta 1	Rattus norvegicus	53-65
28780397-5	2017	On PND8, GBH-exposed rats showed increased Wnt5a and beta-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and beta-catenin expression in subepithelial stroma but decreased beta-catenin expression in glandular epithelium.	gbh	9-12	catenin beta 1	Rattus norvegicus	155-167
28780397-5	2017	On PND8, GBH-exposed rats showed increased Wnt5a and beta-catenin expression in luminal epithelium (LE), whereas on PND21, they showed increased Wnt5a and beta-catenin expression in subepithelial stroma but decreased beta-catenin expression in glandular epithelium.	gbh	9-12	catenin beta 1	Rattus norvegicus	155-167
28780397-6	2017	On GD9, GBH-exposed rats showed decreased Wnt5a and Wnt7a expression in the antimesometrial zone and LE respectively, without changes in beta-catenin expression, while Dkk1 and sFRP4 were up- and down-regulated respectively.	gbh	8-11	catenin beta 1	Rattus norvegicus	137-149
28929374-7	2017	Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	70-82
28929374-7	2017	Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment.	Lithium Chloride	18-22	catenin beta 1	Rattus norvegicus	70-82
28929374-7	2017	Lithium chloride (LiCl), which increases p-GSK-3beta level and active-beta-catenin level, reversed retinal degeneration induced by MNU treatment.	Methylnitrosourea	131-134	catenin beta 1	Rattus norvegicus	70-82
28929374-8	2017	These results suggest that GSK-3beta activation is closely related to photoreceptor cell loss and that the application of the GSK-3beta inhibitor LiCl could activate Wnt/beta-catenin signaling pathway and reduce photoreceptor cell loss induced by MNU.	Lithium Chloride	146-150	catenin beta 1	Rattus norvegicus	170-182
28926590-10	2017	Intraarticular injection of fluoxetine in a rat OA model ameliorated OA progression and suppressed beta-catenin accumulation.	Fluoxetine	28-38	catenin beta 1	Rattus norvegicus	99-111
29104486-10	2017	Therefore, TSN reduced the AngII-induced activation of beta-catenin and IGF-2R pathways, apoptosis and cardiac remodeling via ERs in H9c2 cardiomyoblasts.	tanshinone	11-14	catenin beta 1	Rattus norvegicus	55-67
28807051-12	2017	In MS-1 cells, activation of the beta-catenin-dependent Wnt signaling pathway partially mediated the protective effects of MSCs against H2O2-induced apoptosis and eNOS inhibition.	Hydrogen Peroxide	136-140	catenin beta 1	Rattus norvegicus	33-45
28754618-9	2017	HP significantly prevented TAA-activated Wnt3a/beta-catenin and Wnt5a pathways.	Hesperidin	0-2	catenin beta 1	Rattus norvegicus	47-59
28704753-8	2017	Resveratrol improved fibrosis, which may be associated with the suppression of C-kit/SCF and TGF-beta/Wnt/beta-catenin pathway.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	106-118
28536011-6	2017	XAV939, a beta-catenin inhibitor, attenuated WB cell malignant transformation due to Tg737 knockdown.	XAV939	0-6	catenin beta 1	Rattus norvegicus	10-22
28532855-6	2017	The expression of Grin2b/NR2B, Wnt2, Wnt3a and active form of beta-catenin protein were decreased, and Dickkopf-related protein 1 was increased in the HS group.	hassio	151-153	catenin beta 1	Rattus norvegicus	62-74
28624572-6	2017	Furthermore, downregulating beta-catenin expression in the NAc in shocked rats using sulindac (0.0178, 0.178mg/side) impaired extinction whereas upregulating the Wnt/beta-catenin pathway using LiCl (2microg/side) facilitated extinction.	Sulindac	85-93	catenin beta 1	Rattus norvegicus	28-40
28624572-6	2017	Furthermore, downregulating beta-catenin expression in the NAc in shocked rats using sulindac (0.0178, 0.178mg/side) impaired extinction whereas upregulating the Wnt/beta-catenin pathway using LiCl (2microg/side) facilitated extinction.	Lithium Chloride	193-197	catenin beta 1	Rattus norvegicus	28-40
28624572-8	2017	Importantly, the facilitating effect of WIN55,212-2 on extinction was blocked by co-administration of sulindac in doses that downregulated beta-catenin levels.	win55	40-45	catenin beta 1	Rattus norvegicus	139-151
28624572-8	2017	Importantly, the facilitating effect of WIN55,212-2 on extinction was blocked by co-administration of sulindac in doses that downregulated beta-catenin levels.	Sulindac	102-110	catenin beta 1	Rattus norvegicus	139-151
28462510-0	2017	Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K/AKT/GSK3beta/beta-catenin pathway.	Glucose	22-29	catenin beta 1	Rattus norvegicus	90-102
28462510-9	2017	Collectively, these results indicate that Runx2 alleviates high glucose-induced inhibition of osteoblast differentiation by modulating PI3K/AKT/GSK3beta/beta-catenin pathway.	Glucose	64-71	catenin beta 1	Rattus norvegicus	153-165
27618837-3	2017	DESIGN: Hypomorphic Apc mice (Apcfl/fl) and thiocetamide (TAA)-treated rats developed Wnt/beta-catenin dependent hepatocarcinoma (HCC) and cholangiocarcinoma (CCA), respectively.	thiocetamide	44-56	catenin beta 1	Rattus norvegicus	90-102
27918081-11	2017	Hence, ST1926 may inhibit steroid-induced osteoporosis and promote steroid-induced bone remodeling by regulating the Wnt3a/beta-catenin/NFkappaB signaling pathway.	Steroids	67-74	catenin beta 1	Rattus norvegicus	123-135
28486190-4	2017	Icariin (0.1muM) upregulated TAZ, Runx2, beta-catenin, Osteopotin, and Dlx5 expression mainly at the early stage of osteogenic differentiation, and increased osteocalcin expression at the late stage.	icariin	0-7	catenin beta 1	Rattus norvegicus	41-53
28486190-6	2017	Moreover, ICI 182780 (the estrogen receptor alpha inhibitor) or DKK1 (the Wnt/beta-catenin pathway inhibitor), inhibited the icariin-induced increase in TAZ expression.	icariin	125-132	catenin beta 1	Rattus norvegicus	78-90
28486190-8	2017	Taken together, our results demonstrate that icariin promotes the osteogenic differentiation of rBMSCs by increasing TAZ expression, and that the increased TAZ expression induced by icariin is mostly mediated by the ERalpha and Wnt/beta-catenin pathway.	icariin	182-189	catenin beta 1	Rattus norvegicus	232-244
28621328-6	2017	In vitro, carbacyclin induced proliferation of neonatal and adult mononuclear rat cardiomyocytes via a peroxisome proliferator-activated receptor delta (PPARdelta)/PDK1/p308Akt/GSK3beta/beta-catenin pathway.	carboprostacyclin	10-21	catenin beta 1	Rattus norvegicus	186-198
28371053-4	2017	Furthermore, TiO2 NPs significantly reduced the expression of several proteins involved in canonical Wnt3a/beta-catenin signaling including Wnt3a, beta-catenin, p-GSK-3beta, and CyclinD1 and conversely, elevated GSK-3beta expression.	titanium dioxide	13-17	catenin beta 1	Rattus norvegicus	107-119
28371053-4	2017	Furthermore, TiO2 NPs significantly reduced the expression of several proteins involved in canonical Wnt3a/beta-catenin signaling including Wnt3a, beta-catenin, p-GSK-3beta, and CyclinD1 and conversely, elevated GSK-3beta expression.	titanium dioxide	13-17	catenin beta 1	Rattus norvegicus	147-159
28371053-6	2017	Taken together, these results indicate that suppression of dendritic development caused by TiO2 NPs is associated with inhibition of activation of the Wnt/beta-catenin pathway or non-canonical Wnt pathway-induced expression of microtubule cytoskeletal components in the developing neurons.	titanium dioxide	91-95	catenin beta 1	Rattus norvegicus	155-167
28417262-0	2017	Melatonin Inhibits Neural Cell Apoptosis and Promotes Locomotor Recovery via Activation of the Wnt/beta-Catenin Signaling Pathway After Spinal Cord Injury.	Melatonin	0-9	catenin beta 1	Rattus norvegicus	99-111
28417262-4	2017	In this study, we demonstrated that melatonin exhibited neuroprotective effects on neuronal apoptosis and supported functional recovery in a rat SCI model by activating the Wnt/beta-catenin signaling pathway.	Melatonin	36-45	catenin beta 1	Rattus norvegicus	177-189
28417262-5	2017	We found that melatonin administration after SCI significantly upregulated the expression of low-density lipoprotein receptor related protein 6 phosphorylation (p-LRP-6), lymphoid enhancer factor-1 (LEF-1) and beta-catenin protein in the spinal cord.	Melatonin	14-23	catenin beta 1	Rattus norvegicus	210-222
28417262-8	2017	These results suggest that melatonin attenuated SCI by activating the Wnt/beta-catenin signaling pathway.	Melatonin	27-36	catenin beta 1	Rattus norvegicus	74-86
28315345-0	2017	Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.	Phytic Acid	0-22	catenin beta 1	Rattus norvegicus	93-105
28315345-0	2017	Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3beta/beta-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model.	1,2-Dimethylhydrazine	129-150	catenin beta 1	Rattus norvegicus	93-105
28542131-4	2017	We found that Aroclor1254 treatment in rats (1 or 3 mg/kg per day for 21 consecutive days) and in primary cultured SCs (5 or 10 mug/ml for 48 h) could induce BTB disruption via p38 MAPK pathway, concurrently with increments in junction proteins (JAM-A, N-cadherin, and beta-catenin) endocytosis, and occludin ubiquitination.	Chlorodiphenyl (54% Chlorine)	14-25	catenin beta 1	Rattus norvegicus	269-281
27830450-0	2017	Aluminum Trichloride Inhibited Osteoblastic Proliferation and Downregulated the Wnt/beta-Catenin Pathway.	Aluminum Chloride	0-20	catenin beta 1	Rattus norvegicus	84-96
27830450-9	2017	Taken together, these findings indicated that AlCl3 inhibits osteoblastic proliferation may be associated with the inactivation of Wnt/beta-catenin signaling pathway.	Aluminum Chloride	46-51	catenin beta 1	Rattus norvegicus	135-147
28586911-6	2017	Furthermore, SERPINA3K inhibited the activation of the ROS pathway NRF2 and its downstream factors, NAD(P)H dehydrogenase (quinone) 1 (NQO1) and heme oxygenase 1 (HO1), and also suppressed the activation of the Wnt signaling pathway p-LRP6, beta-catenin, and TCF4 in HCE cells treated with 4-HNE.	Reactive Oxygen Species	55-58	catenin beta 1	Rattus norvegicus	241-253
28586911-6	2017	Furthermore, SERPINA3K inhibited the activation of the ROS pathway NRF2 and its downstream factors, NAD(P)H dehydrogenase (quinone) 1 (NQO1) and heme oxygenase 1 (HO1), and also suppressed the activation of the Wnt signaling pathway p-LRP6, beta-catenin, and TCF4 in HCE cells treated with 4-HNE.	4-hydroxy-2-nonenal	290-295	catenin beta 1	Rattus norvegicus	241-253
28177765-0	2017	Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-gamma expression and hampering miR-17-5p-activated canonical Wnt-beta-catenin signaling.	Diosmin	0-7	catenin beta 1	Rattus norvegicus	136-148
28177765-2	2017	MicroRNA-17-5p (miR-17-5p) is hypothesized to act as a regulator of hepatic stellate cell (HSCs) activation by activation of the canonical Wnt-beta-catenin pathway.	CHEMBL3740941	12-14	catenin beta 1	Rattus norvegicus	143-155
28177765-8	2017	Dios treatment repressed the miR-17-5p activated Wnt-beta-catenin signaling induced by IRR.	Diosmin	0-4	catenin beta 1	Rattus norvegicus	53-65
28177765-8	2017	Dios treatment repressed the miR-17-5p activated Wnt-beta-catenin signaling induced by IRR.	mir-17-5p	29-38	catenin beta 1	Rattus norvegicus	53-65
28177765-10	2017	CONCLUSION: We hypothesize that the stimulation of PPAR-gamma expression and interference with miR-17-5p activated Wnt-beta-catenin signaling mediates the antifibrotic properties of Dios.	mir-17-5p	95-104	catenin beta 1	Rattus norvegicus	119-131
28249195-0	2017	Inhibition of bone formation in rats by aluminum exposure via Wnt/beta-catenin pathway.	Aluminum	40-48	catenin beta 1	Rattus norvegicus	66-78
28249195-1	2017	The previous research found that aluminum trichloride (AlCl3) inhibited rat osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in vitro.	Aluminum Chloride	33-53	catenin beta 1	Rattus norvegicus	133-145
28249195-1	2017	The previous research found that aluminum trichloride (AlCl3) inhibited rat osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in vitro.	Aluminum Chloride	55-60	catenin beta 1	Rattus norvegicus	133-145
28249195-5	2017	These results suggest that AlCl3 inhibits bone formation and induces bone impairment by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats.	Aluminum Chloride	27-32	catenin beta 1	Rattus norvegicus	107-119
28191619-4	2017	Therefore, we studied the relationship between the expression and localization of beta-catenin and apoptosis in mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) in hypothyroid (Hypot) and euthyroid (EUT) rats.	7,12-dimethylbenz	138-155	catenin beta 1	Rattus norvegicus	82-94
28191619-4	2017	Therefore, we studied the relationship between the expression and localization of beta-catenin and apoptosis in mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) in hypothyroid (Hypot) and euthyroid (EUT) rats.	anthracene	158-168	catenin beta 1	Rattus norvegicus	82-94
28191619-4	2017	Therefore, we studied the relationship between the expression and localization of beta-catenin and apoptosis in mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) in hypothyroid (Hypot) and euthyroid (EUT) rats.	9,10-Dimethyl-1,2-benzanthracene	170-174	catenin beta 1	Rattus norvegicus	82-94
28343085-0	2017	Guava fruit extract and its triterpene constituents have osteoanabolic effect: Stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/beta-catenin signaling.	Triterpenes	28-38	catenin beta 1	Rattus norvegicus	176-188
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	Triterpenes	30-41	catenin beta 1	Rattus norvegicus	183-195
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	ursolic acid	49-61	catenin beta 1	Rattus norvegicus	183-195
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	2-hydroxyursolic acid	71-98	catenin beta 1	Rattus norvegicus	183-195
28489093-5	2017	In vitro functional studies demonstrated that the PFTalpha molecules exhibited potent ability to induce osteogenesis of hBMSCs via the GSK3beta/beta-catenin pathway, and the LDH-CS-PFTalpha scaffolds significantly enhanced the osteogenic differentiation of hBMSCs.	pifithrin	50-58	catenin beta 1	Rattus norvegicus	144-156
28415692-3	2017	We found that ethanol inhibited expression of the osteogenic genes RUNX2 and OCN, downregulated osteogenic differentiation, impaired the recruitment of Akt to the plasma membrane, and suppressed Akt phosphorylation at Ser473, thereby inhibiting the Akt/GSK3beta/beta-catenin signaling pathway in bone mesenchymal stem cells.	Ethanol	14-21	catenin beta 1	Rattus norvegicus	262-274
28588757-12	2017	Thiostrepton treatment reduces FOXM1 levels and the nuclear localization of beta-catenin, a known co-activator of both FOXM1 and AR, and reduces the association between beta-catenin and AR.	Thiostrepton	0-12	catenin beta 1	Rattus norvegicus	76-88
28588757-12	2017	Thiostrepton treatment reduces FOXM1 levels and the nuclear localization of beta-catenin, a known co-activator of both FOXM1 and AR, and reduces the association between beta-catenin and AR.	Thiostrepton	0-12	catenin beta 1	Rattus norvegicus	169-181
28415692-6	2017	These results show that alcohol-induced ONFH is associated with suppression of p-Akt-Ser473 in the Akt/GSK3beta/beta-catenin signaling pathway in bone mesenchymal stem cells.	Alcohols	24-31	catenin beta 1	Rattus norvegicus	112-124
27798196-7	2017	Adriamycin also increased the renal expression of Wnt, TGF-beta, and angiotensinogen, as well as the renal abundance of beta-catenin and angiotensin II.	Doxorubicin	0-10	catenin beta 1	Rattus norvegicus	120-132
27085325-8	2017	Sorafenib also exhibited antiproliferative effect through suppression of gene expression of cyclin D1 and beta-catenin.	Sorafenib	0-9	catenin beta 1	Rattus norvegicus	106-118
28447764-0	2017	Sevoflurane anesthesia in pregnant rats negatively affects nerve function in offspring potentially via inhibition of the Wnt/beta-catenin pathway.	Sevoflurane	0-11	catenin beta 1	Rattus norvegicus	125-137
28284729-6	2017	Expression of beta-catenin, COX-2, VEGF, and cyclin D1 was significantly higher in the combined DMH and DEHP-treated rats by comparison to that of the DMH group.	1,2-Dimethylhydrazine	96-99	catenin beta 1	Rattus norvegicus	14-26
28284729-6	2017	Expression of beta-catenin, COX-2, VEGF, and cyclin D1 was significantly higher in the combined DMH and DEHP-treated rats by comparison to that of the DMH group.	Diethylhexyl Phthalate	104-108	catenin beta 1	Rattus norvegicus	14-26
27798196-8	2017	Klotho supplementation suppressed adriamycin-induced elevations of beta-catenin and angiotensin II with sustained Wnt expression.	Doxorubicin	34-44	catenin beta 1	Rattus norvegicus	67-79
28107808-6	2017	beta-catenin expression was partially recovered by treatment with lithium chloride, a canonical Wnt pathway activator.	Lithium Chloride	66-82	catenin beta 1	Rattus norvegicus	0-12
28362171-6	2017	beta-catenin mRNA expression of the crypts was significantly increased in GUAT-fed rats injected with AOM relative to those injected with saline.	Sodium Chloride	138-144	catenin beta 1	Rattus norvegicus	0-12
28593132-0	2017	Activation of Wnt/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.	Lithium Chloride	44-60	catenin beta 1	Rattus norvegicus	18-30
28593132-0	2017	Activation of Wnt/beta-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.	Galactose	72-83	catenin beta 1	Rattus norvegicus	18-30
28593132-6	2017	Activation of Wnt/beta-catenin signaling by Licl attenuated d-gal-induced auditory cortex apoptosis and neurodegeneration.	Lithium Chloride	44-48	catenin beta 1	Rattus norvegicus	18-30
28593132-6	2017	Activation of Wnt/beta-catenin signaling by Licl attenuated d-gal-induced auditory cortex apoptosis and neurodegeneration.	Galactose	60-65	catenin beta 1	Rattus norvegicus	18-30
28485776-0	2017	Isoflurane and sevoflurane affects Wnt/beta-catenin signaling pathways in hippocampal formation of neonatal rats.	Isoflurane	0-10	catenin beta 1	Rattus norvegicus	39-51
28485776-0	2017	Isoflurane and sevoflurane affects Wnt/beta-catenin signaling pathways in hippocampal formation of neonatal rats.	Sevoflurane	15-26	catenin beta 1	Rattus norvegicus	39-51
28485776-11	2017	q-PCR and Western blot demonstrated that isoflurane or sevoflurane affects expression levels of Wnt3a, GSK 3beta and beta-catenin.	Isoflurane	41-51	catenin beta 1	Rattus norvegicus	117-129
28485776-11	2017	q-PCR and Western blot demonstrated that isoflurane or sevoflurane affects expression levels of Wnt3a, GSK 3beta and beta-catenin.	Sevoflurane	55-66	catenin beta 1	Rattus norvegicus	117-129
28338064-0	2017	Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.	Lithium	88-95	catenin beta 1	Rattus norvegicus	52-64
28216152-8	2017	Besides, the beta-catenin/TCF4/GSK-3beta and mTOR signaling were activated both in diabetic rats and in high-glucose cultured H9C2 cells.	Glucose	109-116	catenin beta 1	Rattus norvegicus	13-25
28216152-0	2017	1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the beta-catenin/TCF4/GSK-3beta/mTOR pathway.	Calcitriol	0-24	catenin beta 1	Rattus norvegicus	143-155
28339498-0	2017	Enhancement of osteogenic differentiation of rat adipose tissue-derived mesenchymal stem cells by zinc sulphate under electromagnetic field via the PKA, ERK1/2 and Wnt/beta-catenin signaling pathways.	Zinc Sulfate	98-111	catenin beta 1	Rattus norvegicus	168-180
28338064-0	2017	Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.	Lithium Chloride	110-126	catenin beta 1	Rattus norvegicus	52-64
28339498-9	2017	Real-time PCR analysis showed that ZnSO4, in the presence of EMF, increased the mRNA expressions of beta-catenin, Wnt1, Wnt3a, LRP5 and DKK1.	Zinc Sulfate	35-40	catenin beta 1	Rattus norvegicus	100-112
28338064-0	2017	Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis.	calcium phosphate	127-144	catenin beta 1	Rattus norvegicus	52-64
28339498-10	2017	In this study, it was shown that 0.432 mug/ml ZnSO4, in the presence of 50 Hz, 20 mT EMF, induced the osteogenic differentiation of ADSCs via PKA, ERK1/2 and Wnt/beta-catenin signaling pathways.	Zinc Sulfate	46-51	catenin beta 1	Rattus norvegicus	162-174
28338064-6	2017	Li/CPC extracts stimulated the proliferation and differentiation of osteoblasts upon release of lithium ions (Li+) at 25.35 +- 0.12 to 50.74 +- 0.13 mg/l through activation of the Wnt/beta-catenin pathway in vitro.	cpc	3-6	catenin beta 1	Rattus norvegicus	184-196
28338064-10	2017	These findings suggest that local release of Li+ from Li/CPC may accelerate bone regeneration from injury through activation of the Wnt/beta-catenin pathway in osteoporosis.	cpc	57-60	catenin beta 1	Rattus norvegicus	136-148
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	148-154	catenin beta 1	Rattus norvegicus	117-129
27794200-0	2017	Ellagic acid improves endogenous neural stem cells proliferation and neurorestoration through Wnt/beta-catenin signaling in vivo and in vitro.	Ellagic Acid	0-12	catenin beta 1	Rattus norvegicus	98-110
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	148-154	catenin beta 1	Rattus norvegicus	76-88
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	148-154	catenin beta 1	Rattus norvegicus	117-129
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	148-154	catenin beta 1	Rattus norvegicus	117-129
27977132-0	2017	MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/beta-Catenin Signaling in Parkinsonian Rats.	Dizocilpine Maleate	0-6	catenin beta 1	Rattus norvegicus	122-134
27977132-0	2017	MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/beta-Catenin Signaling in Parkinsonian Rats.	Dizocilpine Maleate	8-19	catenin beta 1	Rattus norvegicus	122-134
27977132-7	2017	MK-801 inhibited glycogen synthase kinase-3beta (GSK-3beta) through up-regulation of Wnt-3a, which resulted in the activation of Wnt/beta-catenin signaling leading to enhanced hippocampal neurogenesis in PD model.	Dizocilpine Maleate	0-6	catenin beta 1	Rattus norvegicus	133-145
28386329-5	2017	Our data indicated that LiCl treatment could attenuates BSCB disruption and improved the recovery of functional locomotion in rats SCI model, reduced the structure damage and number loss of microvessels, increased the expressions of junction proteins, including p120, beta-catenin, occludin, and claudin-5, via reversed the upregulated ER stress associated proteins.	Lithium Chloride	24-28	catenin beta 1	Rattus norvegicus	268-280
28212548-10	2017	In hepatocytes, BCAA restored TGF-beta1-induced apoptosis, lipogenesis, and Wnt/beta-Catenin signaling, and inhibited the transformation of WB-F344 rat liver epithelial stem-like cells.	Amino Acids, Branched-Chain	16-20	catenin beta 1	Rattus norvegicus	80-92
28056548-0	2017	L-carnitine contributes to enhancement of neurogenesis from mesenchymal stem cells through Wnt/beta-catenin and PKA pathway.	Carnitine	0-11	catenin beta 1	Rattus norvegicus	95-107
28056548-18	2017	The results of this study showed that 200 microM LC promoted ADSCs neurogenic differentiation, and that it was correlated with the PKA and Wnt/beta-catenin signaling pathways.	Carnitine	49-51	catenin beta 1	Rattus norvegicus	143-155
26820677-7	2017	Moreover, artesunate elevated S1P1 expression, enhanced phosphatidylinositol 3-kinase activation, lowered GSK-3beta activation, stabilized beta-catenin, and improved the expression of Claudin-3 and Claudin-5 after SAH in rats.	Artesunate	10-20	catenin beta 1	Rattus norvegicus	139-151
26820677-9	2017	This study revealed that artesunate could preserve blood-brain barrier integrity and improve neurological outcome after SAH, possibly through activating S1P1, enhancing phosphatidylinositol 3-kinase activation, stabilizing beta-catenin via GSK-3beta inhibition, and then effectively raising the expression of Claudin-3 and Claudin-5.	Artesunate	25-35	catenin beta 1	Rattus norvegicus	223-235
28063934-0	2017	Morphine administration induces change in anxiety-related behavior via Wnt/beta-catenin signaling.	Morphine	0-8	catenin beta 1	Rattus norvegicus	75-87
28063934-6	2017	The cell cultures indicated that morphine treatment induced beta-catenin expression.	Morphine	33-41	catenin beta 1	Rattus norvegicus	60-72
28063934-11	2017	Additional investigation involving animals suggested that the less anxiety observed in the SD rats after morphine treatment could be caused by the loss of dendritic spines and that this may be related to Wnt/beta-catenin signaling.	Morphine	105-113	catenin beta 1	Rattus norvegicus	208-220
27890731-1	2017	Micro/nano-textured titanium surface topography promotes osteoblast differentiation and the Wnt/beta-catenin signaling pathway.	Titanium	20-28	catenin beta 1	Rattus norvegicus	96-108
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	148-154	catenin beta 1	Rattus norvegicus	117-129
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	344-350	catenin beta 1	Rattus norvegicus	76-88
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	344-350	catenin beta 1	Rattus norvegicus	117-129
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	344-350	catenin beta 1	Rattus norvegicus	117-129
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	344-350	catenin beta 1	Rattus norvegicus	117-129
28220106-4	2017	In this article, we evaluated the levels and cellular localization of liver beta-catenin variants, more specifically beta-catenin phosphorylated in serine 33 (this phosphorylation provides recognizing sites for beta-TrCP, which results in ubiquitination and posterior proteasomal degradation of beta-catenin) and beta-catenin phosphorylated in serine 675 (phosphorylation that enhances signaling and transcriptional activity of beta-catenin through recruitment of different transcriptional coactivators).	Serine	344-350	catenin beta 1	Rattus norvegicus	117-129
28220106-5	2017	beta-catenin phosphorylated in serine 33 in the nucleus shows day-night fluctuations in their expression level in the Ad Libitum group.	Serine	31-37	catenin beta 1	Rattus norvegicus	0-12
29085837-0	2017	Andrographolide Promotes Neural Differentiation of Rat Adipose Tissue-Derived Stromal Cells through Wnt/beta-Catenin Signaling Pathway.	andrographolide	0-15	catenin beta 1	Rattus norvegicus	104-116
27591786-1	2017	Treatment with hydrogen sulfide mitigates spinal cord injury-induced sublesional bone loss, possibly through abating oxidative stress, suppressing MMP activity, and activating Wnt/beta-catenin signaling.	Hydrogen Sulfide	15-31	catenin beta 1	Rattus norvegicus	180-192
27591786-9	2017	Treatment of SCI rats with exogenous H2S reduced malondialdehyde (MDA) levels in serum and femurs, decreased hydroxyproline levels, suppressed activities of matrix metallopeptidase 9 (MMP9), and upregulated Wnt3a, Wnt6, Wnt10, and ctnnb1 expression in femurs.	Hydrogen Sulfide	37-40	catenin beta 1	Rattus norvegicus	231-237
27591786-10	2017	CONCLUSION: Treatment with H2S mitigates SCI-induced sublesional bone loss, possibly through abating oxidative stress, suppressing MMP activity, and activating Wnt/beta-catenin signaling.	Hydrogen Sulfide	27-30	catenin beta 1	Rattus norvegicus	164-176
28758111-5	2017	Both LC3II/LC3I and beta-catenin were enhanced in the MNT group, while XAV939 (a beta-catenin inhibitor) decreased the expression of nuclear erythroid-related factor 2 (Nrf2) and LC3II/LC3I.	XAV939	71-77	catenin beta 1	Rattus norvegicus	81-93
29069652-0	2017	Protective Effect of Curcumin Against Oxidative Stress-Induced Injury in Rats with Parkinson"s Disease Through the Wnt/ beta-Catenin Signaling Pathway.	Curcumin	21-29	catenin beta 1	Rattus norvegicus	120-132
28957807-0	2017	Licochalcone A Inhibits MMPs and ADAMTSs via the NF-kappaB and Wnt/beta-Catenin Signaling Pathways in Rat Chondrocytes.	licochalcone A	0-14	catenin beta 1	Rattus norvegicus	67-79
28957807-6	2017	In addition, the activation of beta-catenin and phosphorylation of p65 and IKKalpha/beta were suppressed by Lico A.	licochalcone A	108-114	catenin beta 1	Rattus norvegicus	31-43
28957807-7	2017	CONCLUSIONS: Our results suggest that Lico A inhibits MMPs and ADAMTS partly via the NF-kappaB and wnt/beta-catenin signaling pathways in rat chondrocytes.	licochalcone A	38-44	catenin beta 1	Rattus norvegicus	103-115
28286769-7	2017	Activation of beta-catenin with LiCl led to increased expression of Runx2 and Collagen I and reduction of C/EBPalpha and PPARgamma expression in BMSCs.	Lithium Chloride	32-36	catenin beta 1	Rattus norvegicus	14-26
29069652-11	2017	CONCLUSION: This study suggests that curcumin could protect against oxidative stress-induced injury in PD rats via the Wnt/beta-catenin signaling pathway.	Curcumin	37-45	catenin beta 1	Rattus norvegicus	123-135
29069652-1	2017	BACKGROUND/AIMS: The study aimed to investigate the protective effect of curcumin against oxidative stress-induced injury of Parkinson"s disease (PD) through the Wnt/beta-catenin signaling pathway in rats.	Curcumin	73-81	catenin beta 1	Rattus norvegicus	166-178
29069652-8	2017	Curcumin enhanced viability, survival and adhesion and attenuated apoptosis of deutocerebrum primary cells by activating the Wnt/beta-catenin signaling pathway.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	129-141
29069652-9	2017	Higher Wnt3a and beta-catenin mRNA and protein expressions and c-myc and cyclinD1 mRNA expressions, enhanced superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) contents, decreased malondialdehyde (MDA) content and elevated mitochondrial membrane potential ( psim) were found in the 10 and 15 micromol/L Cur groups compared with the 6-OHDA group.	Superoxides	109-119	catenin beta 1	Rattus norvegicus	17-29
28194187-9	2017	Activation of the Wnt/beta-catenin pathway by LiCl or BIO modified the effects of hypoxia on the differentiation and self-renewal of MMSCs.	Lithium Chloride	46-50	catenin beta 1	Rattus norvegicus	22-34
29197866-9	2017	In contrast, inhibition of GSK3-beta by TWS119, which specifically inhibits the phosphorylation of Y216, suppressed the phosphorylation of beta-catenin, which resulted in the accumulation of beta-catenin and an increase in the expression of type I collagen.	y216	99-103	catenin beta 1	Rattus norvegicus	139-151
29197866-9	2017	In contrast, inhibition of GSK3-beta by TWS119, which specifically inhibits the phosphorylation of Y216, suppressed the phosphorylation of beta-catenin, which resulted in the accumulation of beta-catenin and an increase in the expression of type I collagen.	y216	99-103	catenin beta 1	Rattus norvegicus	191-203
29158916-0	2017	The Involvement of beta-Catenin/COX-2/VEGF Axis in NMDA-Caused Retinopathy.	N-Methylaspartate	51-55	catenin beta 1	Rattus norvegicus	19-31
29158916-2	2017	Previously, Wnt/beta-catenin signaling has been suggested to be involved in the NMDA-induced retinopathy.	N-Methylaspartate	80-84	catenin beta 1	Rattus norvegicus	16-28
26671619-0	2016	GSK-3beta inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/beta-catenin signaling pathway after acute ischemic stroke in rats.	TWS 119	20-26	catenin beta 1	Rattus norvegicus	100-112
30695430-13	2017	Compared with CU group, protein contents and mRNA expressions of beta-catenin and Rspo-3 in wound tissues decreased, protein contents and mR- NA expressions of GSK-3beta increased in the DU group at day 3, 7, and 14, respectively (P &lt;0.	du	187-189	catenin beta 1	Rattus norvegicus	65-77
30695430-20	2017	SYD could promote the healing of DU possibly by regulating Wnt/beta-catenin signaling pathway.	du	33-35	catenin beta 1	Rattus norvegicus	63-75
27764755-0	2016	Icariin promotes osteogenic differentiation of rat bone marrow stromal cells by activating the ERalpha-Wnt/beta-catenin signaling pathway.	icariin	0-7	catenin beta 1	Rattus norvegicus	107-119
27764755-3	2016	Here, we investigated whether icariin could promote osteogenesis of rBMSCs through modulating the estrogen receptor alpha (ERalpha) and Wnt/beta-catenin signaling pathways, which implicated in rBMSCs osteogenesis.	icariin	30-37	catenin beta 1	Rattus norvegicus	140-152
27764755-6	2016	Additionally, icariin (0.1muM) significantly up-regulated the expression of osteogenic genes (Runx2, osteopotin, DLX5, osteocalcin, collagen type I, and ERalpha) and Wnt signal members (beta-catenin, Lef1, TCF7, c-jun, c-myc, and cyclin D).	icariin	14-21	catenin beta 1	Rattus norvegicus	186-198
27764755-7	2016	Furthermore, icariin stimulated the activation of beta-catenin as evidenced by increased total beta-catenin protein and nuclear translocation.	icariin	13-20	catenin beta 1	Rattus norvegicus	50-62
27764755-7	2016	Furthermore, icariin stimulated the activation of beta-catenin as evidenced by increased total beta-catenin protein and nuclear translocation.	icariin	13-20	catenin beta 1	Rattus norvegicus	95-107
27671803-7	2016	The iron signal was absent when rats (n = 6) were chronically treated with SEN195 (10 mg/kg/day), a small-molecular inhibitor of beta-catenin/TCF-dependent gene transcription.	Iron	4-8	catenin beta 1	Rattus norvegicus	129-141
27671803-7	2016	The iron signal was absent when rats (n = 6) were chronically treated with SEN195 (10 mg/kg/day), a small-molecular inhibitor of beta-catenin/TCF-dependent gene transcription.	sen195	75-81	catenin beta 1	Rattus norvegicus	129-141
27616703-8	2016	RESULTS: We found that postsurgical mechanical and thermal hyperalgesia could be engendered after remifentanil exposure, which was accompanied by a dramatical rise of spinal WNT3a, FZ8, beta-catenin, fractalkine and CX3CR1 levels.	Remifentanil	98-110	catenin beta 1	Rattus norvegicus	186-198
27704140-5	2016	Using rat lens epithelial explants, we demonstrate that ROCK inhibition using Y-27632 prevents TGFbeta-induced nuclear accumulation of MRTF-A, E-cadherin/beta-catenin complex disassembly, and alphaSMA expression.	Y 27632	78-85	catenin beta 1	Rattus norvegicus	154-166
27773659-6	2016	More importantly, Apelin and Irbesartan treatment strikingly prevented TAC-mediated aortic remodeling and adventitial fibrosis in pressure overloaded rats by blocking AT1 receptor and miRNA-122 levels and repressing activation of the CTGF-NFAT5 and LGR4-beta-catenin signaling.	Irbesartan	29-39	catenin beta 1	Rattus norvegicus	254-266
27255553-10	2016	Colonic stem cell marker protein CD133, CD44, and beta-catenin expressions were found to be increased in DMH-induced group of animals as compared to control group of rats.	1,2-Dimethylhydrazine	105-108	catenin beta 1	Rattus norvegicus	50-62
27422367-8	2016	RESULTS: After withdrawal from cocaine self-administration, BRG1 expression and complex formation with SMAD3 are increased in the nucleus accumbens, resulting in increased binding of BRG1 to the promoter regions of Ctnnb1, Mef2d, and Dbn1.	Cocaine	31-38	catenin beta 1	Rattus norvegicus	215-221
28123427-0	2016	Methylprednisolone promotes recovery of neurological function after spinal cord injury: association with Wnt/beta-catenin signaling pathway activation.	Methylprednisolone	0-18	catenin beta 1	Rattus norvegicus	109-121
28123427-2	2016	We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/beta-catenin signaling pathway.	Methylprednisolone	21-39	catenin beta 1	Rattus norvegicus	157-169
28123427-7	2016	At 3 and 7 days post-injury, methylprednisolone up-regulated expression and activation of the Wnt/beta-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 phosphorylation, beta-catenin, and glycogen synthase kinase-3beta phosphorylation.	Methylprednisolone	29-47	catenin beta 1	Rattus norvegicus	98-110
28123427-7	2016	At 3 and 7 days post-injury, methylprednisolone up-regulated expression and activation of the Wnt/beta-catenin signaling pathway, including low-density lipoprotein receptor related protein-6 phosphorylation, beta-catenin, and glycogen synthase kinase-3beta phosphorylation.	Methylprednisolone	29-47	catenin beta 1	Rattus norvegicus	208-256
28123427-8	2016	These results indicate that methylprednisolone-induced neuroprotection may correlate with activation of the Wnt/beta-catenin signaling pathway.	Methylprednisolone	28-46	catenin beta 1	Rattus norvegicus	112-124
27721485-6	2016	Moreover, DMC normalized depressed GCG and GIP transcription by significantly enhancing the GSK-3beta/beta-catenin signaling pathway and expression of TCF7L2, a transactivator of GCG and GIP in diabetic rats.	dmc	10-13	catenin beta 1	Rattus norvegicus	102-114
27445236-0	2016	Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/beta-catenin pathway.	Berberine	0-9	catenin beta 1	Rattus norvegicus	126-138
27445236-0	2016	Berberine promotes proliferation of sodium nitroprusside-stimulated rat chondrocytes and osteoarthritic rat cartilage via Wnt/beta-catenin pathway.	Nitroprusside	36-56	catenin beta 1	Rattus norvegicus	126-138
27445236-6	2016	Notably, inhibition of the Wnt/beta-catenin pathway by XAV939 partially blocked these effects.	XAV939	55-61	catenin beta 1	Rattus norvegicus	31-43
27721485-8	2016	Here, we proposed DMC   GSK-3beta/beta-catenin    TCF7L2    GLP-1, GIP secretion    blood glucose  as a regulatory pathway of blood glucose homeostasis.	dmc	18-21	catenin beta 1	Rattus norvegicus	34-46
27326908-12	2016	The results showed an HI-induced decreased occludin expression at PND 22 and low levels of occludin, beta-catenin and GFAP at PND 60 in the hippocampus of the hypoxic-ischemic rats.	hi	22-24	catenin beta 1	Rattus norvegicus	101-113
27558955-0	2016	Molecular hydrogen suppresses activated Wnt/beta-catenin signaling.	Hydrogen	10-18	catenin beta 1	Rattus norvegicus	44-56
27683908-10	2016	Further, we discovered a new small molecule, dCTB, which targets YAP/TAZ/beta-catenin and can greatly suppress neuropathic pain and the associated neurochemical alterations.	trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile	45-49	catenin beta 1	Rattus norvegicus	73-85
27683908-15	2016	Further, we discovered a new small molecule, dCTB, which targets YAP/TAZ/beta-catenin and can greatly suppress neuropathic pain.	trans-2-[3-(4-tert-Butylphenyl)-2-methyl-2-propenylidene]malononitrile	45-49	catenin beta 1	Rattus norvegicus	73-85
27179990-0	2016	Claulansine F promoted the neuronal differentiation of neural stem and progenitor cells through Akt/GSK-3beta/beta-catenin pathway.	claulansine F	0-13	catenin beta 1	Rattus norvegicus	110-122
27377850-7	2016	Consistently, activation of the Wnt/beta-catenin signaling pathway by LiCl and DeltaN89beta-catenin rescued the inhibitory effect of miR-124 on the chemotactic migration of rMSCs toward HGF, while inhibition of Wnt/beta-catenin signaling by FH535 abrogated the enhanced chemotactic response achieved by the miR-124 inhibitor.	Lithium Chloride	70-74	catenin beta 1	Rattus norvegicus	36-48
27377850-7	2016	Consistently, activation of the Wnt/beta-catenin signaling pathway by LiCl and DeltaN89beta-catenin rescued the inhibitory effect of miR-124 on the chemotactic migration of rMSCs toward HGF, while inhibition of Wnt/beta-catenin signaling by FH535 abrogated the enhanced chemotactic response achieved by the miR-124 inhibitor.	deltan89beta-catenin	79-99	catenin beta 1	Rattus norvegicus	36-48
27377850-7	2016	Consistently, activation of the Wnt/beta-catenin signaling pathway by LiCl and DeltaN89beta-catenin rescued the inhibitory effect of miR-124 on the chemotactic migration of rMSCs toward HGF, while inhibition of Wnt/beta-catenin signaling by FH535 abrogated the enhanced chemotactic response achieved by the miR-124 inhibitor.	FH535	241-246	catenin beta 1	Rattus norvegicus	36-48
27377850-7	2016	Consistently, activation of the Wnt/beta-catenin signaling pathway by LiCl and DeltaN89beta-catenin rescued the inhibitory effect of miR-124 on the chemotactic migration of rMSCs toward HGF, while inhibition of Wnt/beta-catenin signaling by FH535 abrogated the enhanced chemotactic response achieved by the miR-124 inhibitor.	FH535	241-246	catenin beta 1	Rattus norvegicus	87-99
26223802-0	2016	ALCAR Exerts Neuroprotective and Pro-Neurogenic Effects by Inhibition of Glial Activation and Oxidative Stress via Activation of the Wnt/beta-Catenin Signaling in Parkinsonian Rats.	Acetylcarnitine	0-5	catenin beta 1	Rattus norvegicus	137-149
26223802-10	2016	ALCAR pretreatment in 6-OHDA-lesioned rats decreased GSK-3beta activation and increased nuclear translocation of beta-catenin.	Acetylcarnitine	0-5	catenin beta 1	Rattus norvegicus	113-125
26223802-10	2016	ALCAR pretreatment in 6-OHDA-lesioned rats decreased GSK-3beta activation and increased nuclear translocation of beta-catenin.	Oxidopamine	22-28	catenin beta 1	Rattus norvegicus	113-125
26223802-12	2016	These results indicate that ALCAR exerts neuroprotective effects through the activation of Wnt/beta-catenin pathway, suggesting its therapeutic use to treat neurodegenerative diseases by enhancing regenerative capacity.	Acetylcarnitine	28-33	catenin beta 1	Rattus norvegicus	95-107
27240474-10	2016	ATV reduced RANKL and DKK-1 and increased OPG, WNT10b, and beta-catenin expressions and BALP activity.	Atorvastatin	0-3	catenin beta 1	Rattus norvegicus	59-71
27558955-4	2016	We found that H2 suppresses activated Wnt/beta-catenin signaling by promoting phosphorylation and degradation omicronf beta-catenin.	Hydrogen	14-16	catenin beta 1	Rattus norvegicus	42-54
27558955-4	2016	We found that H2 suppresses activated Wnt/beta-catenin signaling by promoting phosphorylation and degradation omicronf beta-catenin.	Hydrogen	14-16	catenin beta 1	Rattus norvegicus	119-131
27558955-5	2016	Either complete inhibition of GSK3 or mutations at CK1- and GSK3-phosphorylation sites of beta-catenin abolished the suppressive effect of H2.	Hydrogen	139-141	catenin beta 1	Rattus norvegicus	90-102
27558955-7	2016	Knock-down of adenomatous polyposis coli (APC) or Axin1, which form the beta-catenin degradation complex, minimized the suppressive effect of H2 on beta-catenin accumulation.	Hydrogen	142-144	catenin beta 1	Rattus norvegicus	72-84
27558955-7	2016	Knock-down of adenomatous polyposis coli (APC) or Axin1, which form the beta-catenin degradation complex, minimized the suppressive effect of H2 on beta-catenin accumulation.	Hydrogen	142-144	catenin beta 1	Rattus norvegicus	148-160
27558955-8	2016	Accordingly, the effect of H2 requires CK1/GSK3-phosphorylation sites of beta-catenin, as well as the beta-catenin degradation complex comprised of CK1, GSK3, APC, and Axin1.	Hydrogen	27-29	catenin beta 1	Rattus norvegicus	73-85
27558955-8	2016	Accordingly, the effect of H2 requires CK1/GSK3-phosphorylation sites of beta-catenin, as well as the beta-catenin degradation complex comprised of CK1, GSK3, APC, and Axin1.	Hydrogen	27-29	catenin beta 1	Rattus norvegicus	102-114
27558955-10	2016	Oral intake of H2 water tended to ameliorate cartilage degradation in a surgery-induced rat osteoarthritis model through attenuating beta-catenin accumulation.	h2 water	15-23	catenin beta 1	Rattus norvegicus	133-145
27558955-11	2016	We first demonstrate that H2 suppresses abnormally activated Wnt/beta-catenin signaling, which accounts for the protective roles of H2 in a fraction of diseases.	Hydrogen	26-28	catenin beta 1	Rattus norvegicus	65-77
27558955-11	2016	We first demonstrate that H2 suppresses abnormally activated Wnt/beta-catenin signaling, which accounts for the protective roles of H2 in a fraction of diseases.	Hydrogen	132-134	catenin beta 1	Rattus norvegicus	65-77
27046338-9	2016	Administration of pioglitazone attenuated the activation of Wnt-beta-catenin signaling.	Pioglitazone	18-30	catenin beta 1	Rattus norvegicus	64-76
27046338-10	2016	Our results show that pioglitazone prevented the development of LV fibrosis and HFpEF in a rat model, at least partly due to attenuated Wnt-beta-catenin signaling.	Pioglitazone	22-34	catenin beta 1	Rattus norvegicus	140-152
26059811-4	2016	Together, our data show that aspirin can directly target oligodendroglial lineage cells and promote their differentiation through inhibition of Wnt/beta-catenin signaling pathway.	Aspirin	29-36	catenin beta 1	Rattus norvegicus	148-160
25963729-8	2016	Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/beta-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3beta siRNA) and inhibitor (Dkk-1).	Curcumin	0-8	catenin beta 1	Rattus norvegicus	99-111
25963729-8	2016	Curcumin-mediated neuroprotection against BPA-induced neurotoxicity involved activation of the Wnt/beta-catenin signaling pathway, which was confirmed by the use of Wnt specific activators (LiCl and GSK-3beta siRNA) and inhibitor (Dkk-1).	bisphenol A	42-45	catenin beta 1	Rattus norvegicus	99-111
27383944-7	2016	PHE group also showed decreased expression of liver cyclin D1 and beta-catenin genes compared with DENA group.	Phenylalanine	0-3	catenin beta 1	Rattus norvegicus	66-78
27435909-5	2016	In the nucleus accumbens, all three drugs increased Akt-GSK3beta signalling; in addition, both aripiprazole and haloperidol, but not bifeprunox, increased the expression of Dvl-3, beta-catenin and GABAA receptors, NMDA receptor subunits, as well as CREB1 phosphorylation levels.	Aripiprazole	95-107	catenin beta 1	Rattus norvegicus	180-212
27435909-5	2016	In the nucleus accumbens, all three drugs increased Akt-GSK3beta signalling; in addition, both aripiprazole and haloperidol, but not bifeprunox, increased the expression of Dvl-3, beta-catenin and GABAA receptors, NMDA receptor subunits, as well as CREB1 phosphorylation levels.	Haloperidol	112-123	catenin beta 1	Rattus norvegicus	180-212
27435909-6	2016	The results suggest that chronic oral administration of aripiprazole affects schizophrenia-related cellular signalling pathways and markers (including Akt-GSK3beta signalling, Dvl-GSK3beta-beta-catenin signalling, GABAA receptor, NMDA receptor and CREB1) in a brain-region-dependent manner; the selective effects of aripiprazole on these signalling pathways might be associated with its unique clinical effects.	Aripiprazole	56-68	catenin beta 1	Rattus norvegicus	189-201
27468227-9	2016	Mechanistically, 5-FU and TQ remarkably cooperated to repress the expression of procancerous Wnt, beta-catenin, NF-kappaB, COX-2, iNOS, VEGF, and TBRAS and upregulate the expression of anti-tumorigenesis DKK-1, CDNK-1A, TGF-beta1, TGF-betaRII, Smad4, and GPx.	Fluorouracil	17-21	catenin beta 1	Rattus norvegicus	98-110
27055478-10	2016	Moreover, ALA obviously inhibited TNF-alpha secretion and Wnt/beta-catenin signaling way.	Thioctic Acid	10-13	catenin beta 1	Rattus norvegicus	62-74
27055478-11	2016	CONCLUSION: These findings indicated that ALA might be a potential therapeutic agent for the protection of articular cartilage against progression of OA through inhibition of oxidative stress, ER stress, inflammatory cytokine secretion, and Wnt/beta-catenin activation.	Thioctic Acid	42-45	catenin beta 1	Rattus norvegicus	245-257
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	bisphenol A	0-3	catenin beta 1	Rattus norvegicus	23-35
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	bisphenol A	0-3	catenin beta 1	Rattus norvegicus	85-97
27131736-0	2016	Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3beta and beta-catenin signaling pathway in PC12 cells.	honokiol	27-35	catenin beta 1	Rattus norvegicus	97-109
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	Curcumin	151-159	catenin beta 1	Rattus norvegicus	23-35
25963729-9	2016	BPA-mediated increased beta-catenin phosphorylation, decreased GSK-3beta levels, and beta-catenin nuclear translocation were significantly reversed by curcumin, leading to enhanced neurogenesis.	Curcumin	151-159	catenin beta 1	Rattus norvegicus	85-97
25963729-12	2016	Overall, our results conclude that curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/beta-catenin signaling pathway.	Curcumin	35-43	catenin beta 1	Rattus norvegicus	138-150
25963729-12	2016	Overall, our results conclude that curcumin provides neuroprotection against BPA-mediated impaired neurogenesis via activation of the Wnt/beta-catenin signaling pathway.	bisphenol A	77-80	catenin beta 1	Rattus norvegicus	138-150
26443048-0	2016	Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/beta-catenin signaling pathway after spinal cord injury.	Simvastatin	0-11	catenin beta 1	Rattus norvegicus	97-109
26443048-3	2016	This study demonstrates that the hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin (Simv) exhibits neuroprotective effects on neuronal apoptosis and supports functional recovery in a rat SCI model by activating the Wnt/beta-catenin signaling pathway.	Simvastatin	86-97	catenin beta 1	Rattus norvegicus	234-246
26443048-3	2016	This study demonstrates that the hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin (Simv) exhibits neuroprotective effects on neuronal apoptosis and supports functional recovery in a rat SCI model by activating the Wnt/beta-catenin signaling pathway.	Simvastatin	99-103	catenin beta 1	Rattus norvegicus	234-246
26443048-7	2016	However, the anti-apoptotic effects of Simv were reduced in cultured spinal cord nerve cells when the Wnt/beta-catenin signaling pathway was suppressed in the lipopolysaccharide-induced model.	Simvastatin	39-43	catenin beta 1	Rattus norvegicus	106-118
26443048-9	2016	This study is the first to report that Simv exerts neuroprotective effects by reducing neuronal apoptosis, and promoting functional and pathological recovery after SCI by activating the Wnt/beta-catenin signaling pathway.	Simvastatin	39-43	catenin beta 1	Rattus norvegicus	190-202
26443048-11	2016	Simvastatin reduced neuronal apoptosis, improved the functional and pathological recovery via activating Wnt/beta-catenin signal pathway, however, the anti-apoptosis effects of simvastatin were reversed following suppressing Wnt/beta-catenin signaling pathway in primary spinal cord neurons.	Simvastatin	0-11	catenin beta 1	Rattus norvegicus	109-121
26443048-11	2016	Simvastatin reduced neuronal apoptosis, improved the functional and pathological recovery via activating Wnt/beta-catenin signal pathway, however, the anti-apoptosis effects of simvastatin were reversed following suppressing Wnt/beta-catenin signaling pathway in primary spinal cord neurons.	Simvastatin	177-188	catenin beta 1	Rattus norvegicus	109-121
26443048-11	2016	Simvastatin reduced neuronal apoptosis, improved the functional and pathological recovery via activating Wnt/beta-catenin signal pathway, however, the anti-apoptosis effects of simvastatin were reversed following suppressing Wnt/beta-catenin signaling pathway in primary spinal cord neurons.	Simvastatin	177-188	catenin beta 1	Rattus norvegicus	229-241
27131736-6	2016	Mechanistic study showed that honokiol could inhibit the activation of glycogen synthase kinase (GSK)-3beta, attenuate the nuclear accumulation of beta-catenin and suppress the phosphorylation of beta-catenin (Ser33/Ser37/Thr41 site) in the Abeta1-42-treated PC12 cells.	honokiol	30-38	catenin beta 1	Rattus norvegicus	147-159
27131736-6	2016	Mechanistic study showed that honokiol could inhibit the activation of glycogen synthase kinase (GSK)-3beta, attenuate the nuclear accumulation of beta-catenin and suppress the phosphorylation of beta-catenin (Ser33/Ser37/Thr41 site) in the Abeta1-42-treated PC12 cells.	honokiol	30-38	catenin beta 1	Rattus norvegicus	196-208
27131736-7	2016	These results indicate that the anti-oxidative and anti-apoptotic effects of honokiol in Abeta1-42-treated PC12 cells may be mediated, at least in part, by regulation the GSK-3beta and beta-catenin signaling pathways.	honokiol	77-85	catenin beta 1	Rattus norvegicus	185-197
27257912-0	2016	Procaine Inhibits Osteo/Odontogenesis through Wnt/beta-Catenin Inactivation.	Procaine	0-8	catenin beta 1	Rattus norvegicus	50-62
29786283-0	2016	[EFFECT OF Wnt/beta-catenin SIGNAL PATHWAY ON APOPTOSIS IN STEROID-INDUCED AVASCULAR NECROSIS OF FEMORAL HEAD IN RATS].	Steroids	59-66	catenin beta 1	Rattus norvegicus	15-27
29786283-1	2016	OBJECTIVE: To investigate the effect of Wnt/beta-catenin signal pathway on the apoptosis in steroid-induced avascular necrosis of femoral head (SANFH) in rats.	Steroids	92-99	catenin beta 1	Rattus norvegicus	44-56
29786283-14	2016	The expression levels of activated beta-catenin and c-Myc were significantly lower in group C than groups A and B (P &amp;lt; 0.05), and in group B than group A (P &amp;lt; 0.05).	Adenosine Monophosphate	118-121	catenin beta 1	Rattus norvegicus	35-47
29786283-14	2016	The expression levels of activated beta-catenin and c-Myc were significantly lower in group C than groups A and B (P &amp;lt; 0.05), and in group B than group A (P &amp;lt; 0.05).	Adenosine Monophosphate	165-168	catenin beta 1	Rattus norvegicus	35-47
27257912-10	2016	In parallel, procaine inhibited canonical Wnt/beta-catenin pathway, observing a loss of nuclear beta-catenin, a decrease in Lrp5 and Frizzled 3, a significant increase of sclerostin and Gsk3beta and an increase of phosphorylated beta-catenin.	Procaine	13-21	catenin beta 1	Rattus norvegicus	46-58
27257912-10	2016	In parallel, procaine inhibited canonical Wnt/beta-catenin pathway, observing a loss of nuclear beta-catenin, a decrease in Lrp5 and Frizzled 3, a significant increase of sclerostin and Gsk3beta and an increase of phosphorylated beta-catenin.	Procaine	13-21	catenin beta 1	Rattus norvegicus	96-108
27257912-10	2016	In parallel, procaine inhibited canonical Wnt/beta-catenin pathway, observing a loss of nuclear beta-catenin, a decrease in Lrp5 and Frizzled 3, a significant increase of sclerostin and Gsk3beta and an increase of phosphorylated beta-catenin.	Procaine	13-21	catenin beta 1	Rattus norvegicus	96-108
27257912-12	2016	Furthermore it was proved that Procaine alone dose dependently increases the expression of Gsk3beta and beta-catenin phosphorylation.	Procaine	31-39	catenin beta 1	Rattus norvegicus	104-116
27257912-15	2016	CONCLUSIONS: Our results demonstrated that procaine administration drastically reduced the mineralization and osteo/odontogenesis of bone marrow mesenchymal stem cells inhibiting Wnt/beta-catenin pathway through the increase of Gsk3beta expression and beta-catenin phosphorylation.	Procaine	43-51	catenin beta 1	Rattus norvegicus	183-195
27257912-15	2016	CONCLUSIONS: Our results demonstrated that procaine administration drastically reduced the mineralization and osteo/odontogenesis of bone marrow mesenchymal stem cells inhibiting Wnt/beta-catenin pathway through the increase of Gsk3beta expression and beta-catenin phosphorylation.	Procaine	43-51	catenin beta 1	Rattus norvegicus	252-264
27108601-9	2016	Furthermore, YQ138 dose-dependently increased the expression of beta-catenin, and decreased the phosphorylation of Tau in CGCs.	yq138	13-18	catenin beta 1	Rattus norvegicus	64-76
27252679-0	2016	Resveratrol Ameliorates the Anxiety- and Depression-Like Behavior of Subclinical Hypothyroidism Rat: Possible Involvement of the HPT Axis, HPA Axis, and Wnt/beta-Catenin Pathway.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	157-169
26521058-6	2016	The TGFbeta1 and Wnt10/beta-catenin pathway took part in the mechanism of bone lesion induced by fluoride, and insulin probably modulated the TGFbeta1 and beta-catenin to exert action on bone turnover during the development of bone lesion.	Fluorides	97-105	catenin beta 1	Rattus norvegicus	23-35
26521058-6	2016	The TGFbeta1 and Wnt10/beta-catenin pathway took part in the mechanism of bone lesion induced by fluoride, and insulin probably modulated the TGFbeta1 and beta-catenin to exert action on bone turnover during the development of bone lesion.	Fluorides	97-105	catenin beta 1	Rattus norvegicus	155-167
27020656-9	2016	Mechanistically, paricalcitol and 5-FU had cooperated together to repress the expression of procancerous Wnt, beta-catenin, NF-kappaB, COX-2, iNOS, VEGF, and HSP-90 more, and to upregulate the expression of antitumorigenesis DKK-1 and CDNK-1A, compared with their monotherapies.	paricalcitol	17-29	catenin beta 1	Rattus norvegicus	110-122
27020656-9	2016	Mechanistically, paricalcitol and 5-FU had cooperated together to repress the expression of procancerous Wnt, beta-catenin, NF-kappaB, COX-2, iNOS, VEGF, and HSP-90 more, and to upregulate the expression of antitumorigenesis DKK-1 and CDNK-1A, compared with their monotherapies.	Fluorouracil	34-38	catenin beta 1	Rattus norvegicus	110-122
27468552-10	2016	Compared with the control group, total and nuclear beta-catenin proteins, as well as beta-catenin mRNA expression, were all increased with icariin treatment.	icariin	139-146	catenin beta 1	Rattus norvegicus	51-63
27468552-10	2016	Compared with the control group, total and nuclear beta-catenin proteins, as well as beta-catenin mRNA expression, were all increased with icariin treatment.	icariin	139-146	catenin beta 1	Rattus norvegicus	85-97
27214381-8	2016	The pan-NADPH oxidase (NOX) inhibitor diphenyleneiodonium (DPI) also reduces both MeCP2 and stabilized non-(S33/S37/Thr41)-phospho beta-catenin and reverts aHSC to quiescent cells but do not affect miR-132/miR-212 levels.	diphenyleneiodonium	38-57	catenin beta 1	Rattus norvegicus	131-143
27214381-8	2016	The pan-NADPH oxidase (NOX) inhibitor diphenyleneiodonium (DPI) also reduces both MeCP2 and stabilized non-(S33/S37/Thr41)-phospho beta-catenin and reverts aHSC to quiescent cells but do not affect miR-132/miR-212 levels.	diphenyleneiodonium	59-62	catenin beta 1	Rattus norvegicus	131-143
26458922-0	2016	Lithium prevents rat steroid-related osteonecrosis of the femoral head by beta-catenin activation.	Lithium	0-7	catenin beta 1	Rattus norvegicus	74-86
27101927-11	2016	Compared with LPS group, after preincubated with HSP90 inhibitor 17-AAG, the LPS-induced enhancement of active beta-catenin protein and nuclear beta-catenin protein was abolished.	tanespimycin	65-71	catenin beta 1	Rattus norvegicus	111-123
27101927-11	2016	Compared with LPS group, after preincubated with HSP90 inhibitor 17-AAG, the LPS-induced enhancement of active beta-catenin protein and nuclear beta-catenin protein was abolished.	tanespimycin	65-71	catenin beta 1	Rattus norvegicus	144-156
26964897-0	2016	Niclosamide blocks glucagon phosphorylation of Ser552 on beta-catenin in primary rat hepatocytes via PKA signalling.	Niclosamide	0-11	catenin beta 1	Rattus norvegicus	57-69
26964897-0	2016	Niclosamide blocks glucagon phosphorylation of Ser552 on beta-catenin in primary rat hepatocytes via PKA signalling.	Glucagon	19-27	catenin beta 1	Rattus norvegicus	57-69
26494018-4	2016	The results show that the greatest heroin-induced suppression of intake of a saccharin cue is associated with the greatest vulnerability to later addiction-like behavior and to differences in the expression of WLS, beta-catenin, and NCS-1 in brain compared to rats that exhibited the least suppression of intake of the heroin-paired cue and/or saline controls.	Heroin	35-41	catenin beta 1	Rattus norvegicus	215-227
26912210-7	2016	Blocking Wnt signaling using a Frizzled receptor inhibitor (Niclosamide) abolished TGF-beta/Smad3-induced beta-catenin stabilization.	Niclosamide	60-71	catenin beta 1	Rattus norvegicus	106-118
26964897-1	2016	Recently, it has been found that glucagon is able to activate the beta-catenin signalling pathway leading to increased cyclin D1 and c-Myc expression in liver.	Glucagon	33-41	catenin beta 1	Rattus norvegicus	66-78
26964897-2	2016	Therefore the main aim of the present study is to determine whether the effect of glucagon activating beta-catenin signalling leading to increased target gene expression is mediated through cAMP activation of PKA (protein kinase A).	Cyclic AMP	190-194	catenin beta 1	Rattus norvegicus	102-114
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Glucagon	60-68	catenin beta 1	Rattus norvegicus	138-150
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Epinephrine	72-82	catenin beta 1	Rattus norvegicus	138-150
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Serine	110-113	catenin beta 1	Rattus norvegicus	138-150
26964897-6	2016	Interestingly, both niclosamide and the PKA inhibitor H89 blocked the glucagon effect on beta-catenin signalling, leading to a reduction in target gene expression.	Niclosamide	20-31	catenin beta 1	Rattus norvegicus	89-101
26964897-7	2016	Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser(552) phosphorylation of beta-catenin.	Niclosamide	10-21	catenin beta 1	Rattus norvegicus	153-165
26964897-7	2016	Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser(552) phosphorylation of beta-catenin.	Cyclic AMP	32-36	catenin beta 1	Rattus norvegicus	153-165
26964897-7	2016	Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser(552) phosphorylation of beta-catenin.	Bucladesine	71-78	catenin beta 1	Rattus norvegicus	153-165
26964897-7	2016	Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser(552) phosphorylation of beta-catenin.	Bucladesine sodium	80-106	catenin beta 1	Rattus norvegicus	153-165
26964897-7	2016	Likewise, niclosamide inhibited cAMP levels and the direct addition of db-cAMP (dibutyryl-cAMP sodium salt) also resulted in Ser(552) phosphorylation of beta-catenin.	Serine	125-128	catenin beta 1	Rattus norvegicus	153-165
26964897-8	2016	We have identified a new pathway via glucagon signalling that leads to increased beta-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes).	Glucagon	37-45	catenin beta 1	Rattus norvegicus	81-93
26964897-8	2016	We have identified a new pathway via glucagon signalling that leads to increased beta-catenin activity that can be reversed with the antihelminthic drug niclosamide, which has recently shown promise as a potential treatment of T2D (Type 2 diabetes).	Niclosamide	153-164	catenin beta 1	Rattus norvegicus	81-93
26458922-0	2016	Lithium prevents rat steroid-related osteonecrosis of the femoral head by beta-catenin activation.	Steroids	21-28	catenin beta 1	Rattus norvegicus	74-86
26458922-1	2016	This study explored the use of lithium to prevent rat steroid-related osteonecrosis of the femoral head (ONFH) through the modulation of the beta-catenin pathway.	Lithium	31-38	catenin beta 1	Rattus norvegicus	141-153
26458922-11	2016	Furthermore, local beta-catenin was reduced in steroid-related ONFH, and lithium treatment increased beta-catenin expression while reducing p-Tyr(216) GSK-3beta levels.	Steroids	47-54	catenin beta 1	Rattus norvegicus	19-31
26458922-11	2016	Furthermore, local beta-catenin was reduced in steroid-related ONFH, and lithium treatment increased beta-catenin expression while reducing p-Tyr(216) GSK-3beta levels.	Lithium	73-80	catenin beta 1	Rattus norvegicus	101-113
26458922-12	2016	The local beta-catenin pathway was inhibited during steroid-related ONFH.	Steroids	52-59	catenin beta 1	Rattus norvegicus	10-22
26458922-13	2016	Lithium may enhance angiogenesis and stabilize osteogenic/adipogenic homeostasis during steroid-related ONFH in rats by activating the beta-catenin pathway.	Lithium	0-7	catenin beta 1	Rattus norvegicus	135-147
27035393-10	2016	These findings suggest that hydrosulfide exerts cardioprotective effects against AMI-induced apoptosis through the GSK-3beta/beta-catenin signaling pathway.	hydrosulfide	28-40	catenin beta 1	Rattus norvegicus	125-137
26970306-7	2016	Inhibition of the Wnt/beta-catenin pathway by the specific inhibitor XAV939 markedly attenuated Ang II-induced cardiomyocyte hypertrophy.	XAV939	69-75	catenin beta 1	Rattus norvegicus	22-34
27035393-0	2016	Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3beta/beta-catenin signaling pathway.	hydrosulfide	0-12	catenin beta 1	Rattus norvegicus	100-112
27035393-8	2016	The administration of NaHS and SB216763 increased the concentrations of phosphorylated (p-)GSK-3beta, the p-GSK-3beta/t-GSK-3beta ratio and downstream protein beta-catenin.	sodium bisulfide	22-26	catenin beta 1	Rattus norvegicus	159-171
27035393-8	2016	The administration of NaHS and SB216763 increased the concentrations of phosphorylated (p-)GSK-3beta, the p-GSK-3beta/t-GSK-3beta ratio and downstream protein beta-catenin.	SB 216763	31-39	catenin beta 1	Rattus norvegicus	159-171
26797524-0	2016	Neuroprotective Potential of Novel Multi-Targeted Isoalloxazine Derivatives in Rodent Models of Alzheimer"s Disease Through Activation of Canonical Wnt/beta-Catenin Signalling Pathway.	isoalloxazine	50-63	catenin beta 1	Rattus norvegicus	152-164
26970306-9	2016	The AT1R antagonist losartan inhibited Ang II-stimulated activation of the Wnt/beta-catenin pathway and cardiomyocyte hypertrophy.	Losartan	20-28	catenin beta 1	Rattus norvegicus	79-91
26872974-4	2016	Furthermore, activation of the canonical Wnt/beta-catenin pathway in RBE4 cells via nuclear beta-catenin signaling with LiCl does not alter brain endothelialMct1mRNA but increases the amount of MCT1 transporter protein.	Lithium Chloride	120-124	catenin beta 1	Rattus norvegicus	45-57
27109829-7	2016	Our studies suggest that the down-regulation of Sema3A and the subsequent inactivation of Wnt/beta-catenin signalling may be some of the mechanisms involved in USN-induced osteoporosis.	usn	160-163	catenin beta 1	Rattus norvegicus	94-106
26911934-1	2016	Neonatal exposure to a low dose of endosulfan may disrupt the expression of Wnt7a and beta-catenin during uterine development leading to the failure of uterine functional differentiation during implantation.	Endosulfan	35-45	catenin beta 1	Rattus norvegicus	86-98
26872974-4	2016	Furthermore, activation of the canonical Wnt/beta-catenin pathway in RBE4 cells via nuclear beta-catenin signaling with LiCl does not alter brain endothelialMct1mRNA but increases the amount of MCT1 transporter protein.	Lithium Chloride	120-124	catenin beta 1	Rattus norvegicus	92-104
26872974-6	2016	Inhibition of the Notch pathway by the gamma-secretase inhibitorN-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycinet-butyl ester negated the up-regulation of MCT1 by LiCl, demonstrating a cross-talk between the canonical Wnt/beta-catenin and Notch pathways.	-[n-(3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycinet-butyl ester	65-132	catenin beta 1	Rattus norvegicus	229-241
26992258-2	2016	Wnt5a/beta-catenin depression and induction of superoxide synthesis are associated with high glucose (HG) induced transforming growth factor (TGF)-beta1 and fibronectin expression in mesangial cells.	Glucose	93-100	catenin beta 1	Rattus norvegicus	6-18
27073458-6	2016	Furthermore, the Wnt4, beta-catenin and TGF-beta1 protein expression levels were suppressed in the YQ-S group (P&lt;0.01 or P&lt;0.05).	yq-s	99-103	catenin beta 1	Rattus norvegicus	23-35
27043526-8	2016	Additionally, both aripiprazole and haloperidol, but not bifeprunox, increased the expression of Dvl-3 and beta-catenin in the NAc.	Aripiprazole	19-31	catenin beta 1	Rattus norvegicus	107-119
27043526-8	2016	Additionally, both aripiprazole and haloperidol, but not bifeprunox, increased the expression of Dvl-3 and beta-catenin in the NAc.	Haloperidol	36-47	catenin beta 1	Rattus norvegicus	107-119
27043526-9	2016	The present study suggests that activation of GSK3beta phosphorylation in the PFC and NAc may be involved in the clinical profile of aripiprazole; additionally, aripiprazole can increase GSK3beta phosphorylation via the Dvl-GSK3beta-beta-catenin signalling pathway in the NAc, probably due to its relatively low intrinsic activity at D2Rs.	Aripiprazole	161-173	catenin beta 1	Rattus norvegicus	233-245
26992258-6	2016	Curcumin treatment reduced the TGF-beta1 and fibronectin activation and the inhibiting effect of diabetes on Wnt5a/beta-catenin expression in renal glomeruli.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	115-127
26992258-8	2016	Curcumin alleviated extracellular matrix accumulation in diabetic nephropathy by not only preventing the diabetes-mediated superoxide synthesis but also resuming downregulation of Wnt/beta-catenin signaling.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	184-196
27045591-0	2016	Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.	Rotenone	84-92	catenin beta 1	Rattus norvegicus	10-22
27045591-2	2016	Increasing evidence showed that Wnt/beta-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3beta antagonists LiCl and SB216763 were used to activate Wnt/beta-catenin pathway experimentally.	Lithium Chloride	213-217	catenin beta 1	Rattus norvegicus	36-48
27045591-2	2016	Increasing evidence showed that Wnt/beta-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3beta antagonists LiCl and SB216763 were used to activate Wnt/beta-catenin pathway experimentally.	SB 216763	222-230	catenin beta 1	Rattus norvegicus	36-48
27045591-6	2016	The activity of Wnt/beta-catenin pathway was deregulated on exposure of rotenone in a concentration-dependent manner.	Rotenone	72-80	catenin beta 1	Rattus norvegicus	20-32
27045591-8	2016	Our data confirmed that Wnt/beta-catenin signaling activated by LiCl or SB216763 enhanced Nurr1 expression to 2.75 +- 0.55 and 4.06 +- 0.41 folds respectively compared with control detected by real-time PCR and the interaction of beta-catenin with Nurr1 was identified by co-immunoprecipitate analysis.	SB 216763	72-80	catenin beta 1	Rattus norvegicus	28-40
27045591-8	2016	Our data confirmed that Wnt/beta-catenin signaling activated by LiCl or SB216763 enhanced Nurr1 expression to 2.75 +- 0.55 and 4.06 +- 0.41 folds respectively compared with control detected by real-time PCR and the interaction of beta-catenin with Nurr1 was identified by co-immunoprecipitate analysis.	SB 216763	72-80	catenin beta 1	Rattus norvegicus	230-242
26781174-0	2016	HIF-1alpha regulates EMT via the Snail and beta-catenin pathways in paraquat poisoning-induced early pulmonary fibrosis.	Paraquat	68-76	catenin beta 1	Rattus norvegicus	43-55
26781174-4	2016	However, the relationship among HIF-1alpha, Snail and beta-catenin in PQ poisoning-induced pulmonary fibrosis is not clear.	Paraquat	70-72	catenin beta 1	Rattus norvegicus	54-66
26781174-13	2016	These data demonstrate that EMT may be involved in PQ poisoning-induced pulmonary fibrosis and regulated by HIF-1alpha via the Snail and beta-catenin pathways.	Paraquat	51-53	catenin beta 1	Rattus norvegicus	137-149
26767983-3	2016	In the present work, we took advantage of the ability of lipofectamine-like reagent to cause a synchronous dissociation of adherent junctions in cells isolated from the rat enteric nervous system (ENS) for obtaining an in vitro model of deregulated beta-catenin signaling.	Lipofectamine	57-70	catenin beta 1	Rattus norvegicus	249-261
26992258-3	2016	Curcumin resumes HG depression of Wnt/beta-catenin signaling and alleviates HG induction of superoxide, TGF-beta1 and fibronectin expression in renal mesangial cell.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	38-50
26878280-0	2016	Aluminum trichloride inhibits osteoblastic differentiation through inactivation of Wnt/beta-catenin signaling pathway in rat osteoblasts.	Aluminum Chloride	0-20	catenin beta 1	Rattus norvegicus	87-99
25926526-0	2016	Radioprotection of 1,2-dimethylhydrazine-initiated colon cancer in rats using low-dose gamma rays by modulating multidrug resistance-1, cytokeratin 20, and beta-catenin expression.	1,2-Dimethylhydrazine	19-40	catenin beta 1	Rattus norvegicus	156-168
25926526-8	2016	Moreover, gamma ray reduced the expressions of multidrug resistance 1 (MDR1), beta-catenin, and cytokeratin 20 (CK20) those increased in DMH-treated rats.	1,2-Dimethylhydrazine	137-140	catenin beta 1	Rattus norvegicus	78-90
25926526-12	2016	In conclusion, the present results showed that low-dose gamma ray significantly inhibited DMH-induced colon carcinogenesis in rats by modulating CK20, MDR1, and beta-catenin expression but not survivin expression.	1,2-Dimethylhydrazine	90-93	catenin beta 1	Rattus norvegicus	161-173
26878280-6	2016	Moreover, we found exogenous Wnt3a application reversed the inhibitory effect of AlCl3 on osteoblastic differentiation, accompanied by activating the Wnt/beta-catenin pathway.	Aluminum Chloride	81-86	catenin beta 1	Rattus norvegicus	154-166
26709094-0	2016	Tanshinone IIA promotes the proliferation of WB-F344 hepatic oval cells via Wnt/beta-catenin signaling.	tanshinone	0-14	catenin beta 1	Rattus norvegicus	80-92
26878280-7	2016	Taken together, these findings suggest that AlCl3 inhibites osteoblastic differentiation through inactivation of Wnt/beta-catenin pathway in osteoblasts.	Aluminum Chloride	44-49	catenin beta 1	Rattus norvegicus	117-129
26677102-15	2016	Immunofluorescence staining revealed that curcumin restored the intranuclear staining of beta-catenin in the DXM-stimulated osteoblasts.	Curcumin	42-50	catenin beta 1	Rattus norvegicus	89-101
26677102-15	2016	Immunofluorescence staining revealed that curcumin restored the intranuclear staining of beta-catenin in the DXM-stimulated osteoblasts.	Dexamethasone	109-112	catenin beta 1	Rattus norvegicus	89-101
26414021-5	2016	The Wnt activator WAY-262611 and beta-catenin activator lithium chloride (LiCl) were used to activate the pathway at distinct levels in HSCs.	Lithium Chloride	56-72	catenin beta 1	Rattus norvegicus	33-45
26414021-5	2016	The Wnt activator WAY-262611 and beta-catenin activator lithium chloride (LiCl) were used to activate the pathway at distinct levels in HSCs.	Lithium Chloride	74-78	catenin beta 1	Rattus norvegicus	33-45
26414021-9	2016	Curcumin also reduced the expression of Frizzled and beta-catenin, upregulated the expression of adipogenic transcription factors, and restored lipid content in HSCs.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	53-65
26709094-4	2016	In the present study, low to moderate concentrations of TSA were observed to stimulate proliferation, did not induce apoptosis in WB-F344 rat hepatic oval cells and the increased expression levels of beta-catenin.	tanshinone	56-59	catenin beta 1	Rattus norvegicus	200-212
26420483-0	2015	Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-beta Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/beta-Catenin Pathway.	Ethosuximide	0-12	catenin beta 1	Rattus norvegicus	184-196
28871695-0	2016	[Icaritin promotes chondrogenic differentiation of BMSCs by Wnt/beta-catenin signaling pathway].	icaritin	1-9	catenin beta 1	Rattus norvegicus	64-76
28871695-10	2016	ICT can promote the chondrogenic differentiation of BMSCs in vitro probably by activating the Wnt/beta-catenin signaling pathway.	icaritin	0-3	catenin beta 1	Rattus norvegicus	98-110
27051474-5	2016	Meanwhile, tanshinol diminished inhibition of protein expression of beta-catenin and Tcf4 and transcription activity of Tcf4-luc induced by GC, especially under conditions of KLF siRNA in vitro.	tanshinol	11-20	catenin beta 1	Rattus norvegicus	68-80
26474975-0	2015	Aluminum trichloride impairs bone and downregulates Wnt/beta-catenin signaling pathway in young growing rats.	Aluminum Chloride	0-20	catenin beta 1	Rattus norvegicus	56-68
26474975-6	2015	These results indicated that AlCl3 impaired femora by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats.	Aluminum Chloride	29-34	catenin beta 1	Rattus norvegicus	73-85
26474698-0	2015	Myeloperoxidase-derived hypochlorous acid promotes ox-LDL-induced senescence of endothelial cells through a mechanism involving beta-catenin signaling in hyperlipidemia.	Hypochlorous Acid	24-41	catenin beta 1	Rattus norvegicus	128-140
26637809-6	2016	Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1).	salvianolic acid B	15-20	catenin beta 1	Rattus norvegicus	63-75
26637809-6	2016	Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1).	salvianolic acid B	15-20	catenin beta 1	Rattus norvegicus	107-119
26637809-11	2016	Collectively, we demonstrated that miR-17-5p activates Wnt/beta-catenin pathway to result in HSC activation through inhibiting WIF1 expression.	mir-17-5p	35-44	catenin beta 1	Rattus norvegicus	59-71
27300751-0	2016	An Inhibitory Role of Osthole in Rat MSCs Osteogenic Differentiation and Proliferation via Wnt/beta-Catenin and Erk1/2-MAPK Pathways.	osthol	22-29	catenin beta 1	Rattus norvegicus	95-107
27300751-8	2016	The underlying mechanism of Osthole-induced osteogenesis was further evaluated by western blotting with antibodies in Wnt/beta-catenin, PI3K/Akt, BMPs/smad1/5/8, and MAPK signaling pathways.	osthol	28-35	catenin beta 1	Rattus norvegicus	122-134
27300751-10	2016	Osthole suppressed osteogenic differentiation of rat MSCs by down-regulating the activities of Wnt/beta-catenin and Erk1/2-MAPK signaling.	osthol	0-7	catenin beta 1	Rattus norvegicus	99-111
27300751-11	2016	CONCLUSIONS: Osthole inhibits the proliferation and osteogenic differentiation of rat MSCs, which might be mediated through blocking the Wnt/beta-catenin and Erk1/2-MAPK signaling pathways.	osthol	13-20	catenin beta 1	Rattus norvegicus	141-153
26722220-4	2016	RA attenuated BSCB permeability and decreased the loss of tight junction (TJ) molecules such as P120, beta-catenin, Occludin and Claudin5 after injury in vivo as well as in Brain Microvascular Endothelial Cells (BMECs).	Tretinoin	0-2	catenin beta 1	Rattus norvegicus	102-114
27232632-5	2016	In DMH-treated rats, the extracts partially normalized the levels of FRAP, CYP450, beta-catenin, and GST.	1,2-Dimethylhydrazine	3-6	catenin beta 1	Rattus norvegicus	83-95
26541456-5	2015	In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/beta-catenin signaling pathways.	naringin	15-23	catenin beta 1	Rattus norvegicus	199-211
26703530-3	2015	The present study was designed to investigate the effects of PE treatment on intratumor expression of estrogen receptor (ER)-alpha, ER-beta,beta-catenin and cyclin D1 during DMBA rat mammary carcinogenesis.	pe	61-63	catenin beta 1	Rattus norvegicus	140-152
26703530-9	2015	Our current results in conjunction with our previous findings indicate that concurrent disruption of ER and Wnt/beta-catenin signaling pathways possibly contributes to antiproliferative and proapoptotic effects involved in PE-mediated chemoprevention of DMBA-inflicted rat mammary tumorigenesis.	9,10-Dimethyl-1,2-benzanthracene	254-258	catenin beta 1	Rattus norvegicus	112-124
26386043-0	2015	GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway.	Palmitates	34-43	catenin beta 1	Rattus norvegicus	76-85
26386043-5	2015	This study was designed to evaluate the role of b-catenin signalling in palmitate-induced cardiomyocyte apoptosis and the molecular mechanism underlying the protective effects of GLP1 on palmitate-stressed cardiomyocytes.	Palmitates	72-81	catenin beta 1	Rattus norvegicus	48-57
26386043-11	2015	Collectively, our results demonstrated for the first time that the attenuated b-catenin signalling may contribute to palmitate-induced cardiomyocyte apoptosis, while GLP1 can protect cardiomyocytes from palmitate-induced apoptosis through activation of GLP1R/Akt/GSK3b-mediated b-catenin signalling.	Palmitates	117-126	catenin beta 1	Rattus norvegicus	78-87
25381574-0	2015	Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/beta-Catenin Pathway.	bisphenol A	22-33	catenin beta 1	Rattus norvegicus	127-139
25381574-4	2015	Herein, we studied the effect(s) of prenatal and early postnatal exposure of low dose BPA on Wnt/beta-catenin signaling pathway that controls different steps of neurogenesis such as neural stem cell (NSC) proliferation and neuronal differentiation.	bisphenol A	86-89	catenin beta 1	Rattus norvegicus	97-109
25381574-9	2015	BPA reduced cellular beta-catenin and p-GSK-3beta levels and decreased beta-catenin nuclear translocation, and cyclin-D1 and TCF/LEF promoter luciferase activity.	bisphenol A	0-3	catenin beta 1	Rattus norvegicus	21-33
25381574-9	2015	BPA reduced cellular beta-catenin and p-GSK-3beta levels and decreased beta-catenin nuclear translocation, and cyclin-D1 and TCF/LEF promoter luciferase activity.	bisphenol A	0-3	catenin beta 1	Rattus norvegicus	71-83
25381574-12	2015	Overall, these results suggest significant inhibitory effects of BPA on NSC proliferation and differentiation in the rat via the Wnt/beta-catenin signaling pathway.	bisphenol A	65-68	catenin beta 1	Rattus norvegicus	133-145
26054493-2	2015	Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities.	Lithium Chloride	30-46	catenin beta 1	Rattus norvegicus	129-141
26054493-2	2015	Our previous study shows that lithium chloride (LiCl) optimizes skeletal myoblast (SkM) for transplantation by mimicking the Wnt/beta-catenin signaling activities.	Lithium Chloride	48-52	catenin beta 1	Rattus norvegicus	129-141
26420483-8	2015	ETH inhibited Abeta-mediated suppression of neurogenic and Akt/Wnt/beta-catenin pathway gene expression in the hippocampus.	Ethosuximide	0-3	catenin beta 1	Rattus norvegicus	67-79
26420483-9	2015	ETH activated the PI3K Akt and Wnt beta-catenin transduction pathways that are known to be involved in the regulation of neurogenesis.	Ethosuximide	0-3	catenin beta 1	Rattus norvegicus	35-47
26420483-10	2015	Inhibition of the PI3K Akt and Wnt beta-catenin pathways effectively blocked the mitogenic and neurogenic effects of ETH.	Ethosuximide	117-120	catenin beta 1	Rattus norvegicus	35-47
26420483-12	2015	Our findings suggest that ETH stimulates NSC proliferation and differentiation in vitro and adult hippocampal neurogenesis via the PI3K Akt and Wnt beta-catenin signaling.	Ethosuximide	26-29	catenin beta 1	Rattus norvegicus	148-160
26018040-9	2015	Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3.	Lithium Chloride	72-88	catenin beta 1	Rattus norvegicus	38-50
26474698-6	2015	Replacement of ox-LDL with HOCl could also induce HUVECs senescence and activate the beta-catenin/p53 pathway.	Hypochlorous Acid	27-31	catenin beta 1	Rattus norvegicus	85-97
26018040-9	2015	Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3.	Lithium Chloride	72-88	catenin beta 1	Rattus norvegicus	146-158
26018040-9	2015	Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3.	Lithium Chloride	90-94	catenin beta 1	Rattus norvegicus	38-50
26018040-9	2015	Exposure of co-cultured MSCs to a Wnt/beta-catenin signaling activator, lithium chloride (LiCl, 20 microM) increased phosphorylated GSK-3beta and beta-catenin and enhanced expression of AE1/AE3.	Lithium Chloride	90-94	catenin beta 1	Rattus norvegicus	146-158
26283324-11	2015	These data suggest that Curculigoside A induces cell proliferation and angiogenesis through the Wnt5a/beta-catenin and VEGF/CREB/Egr-3/VCAM-1 signaling axis and promotes maturation and stability of new blood vessels via increasing Ang1 and Tie-2 expression.	curculigoside	24-39	catenin beta 1	Rattus norvegicus	102-114
26352537-0	2015	Lithium chloride attenuates the abnormal osteogenic/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the beta-catenin pathway.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	197-209
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Lithium Chloride	17-21	catenin beta 1	Rattus norvegicus	89-101
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Lithium Chloride	17-21	catenin beta 1	Rattus norvegicus	252-264
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Quercetin	220-229	catenin beta 1	Rattus norvegicus	89-101
26352537-8	2015	These effects of LiCl on the ONFH-BMMSCs were associated with an increased expression of beta-catenin and a decreased expression of phosphorylated GSK-3beta at Tyr-216, and these effects were abolished by treatment with quercetin, an antagonist of the beta-catenin pathway.	Quercetin	220-229	catenin beta 1	Rattus norvegicus	252-264
26352537-10	2015	However, as demonstrated by our findings, LiCl reduces abnormal adipogenic activity and simultaneously increases the osteogenic differentiation of ONFH-BMMSCs by activating the beta-catenin pathway.	Lithium Chloride	42-46	catenin beta 1	Rattus norvegicus	177-189
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	122-134
26887261-6	2015	The 25.00, 50.00 and 100.00 micromol/L PQ treatment groups mRNA expression of Wnt pathway key genes including Fzd1, Dvl2 and beta-catenin and downstream genes including apoptosis suppressor genes (Bcl-2 and survivin)and cyclin gene (Cyclin D1) were downregulated (P&lt;0.05).	Primaquine	39-41	catenin beta 1	Rattus norvegicus	125-137
26300394-10	2015	In conclusions, treatment with curcumin abated oxidative stress, activated VDR, and enhanced Wnt/beta-catenin pathway, which might explain its beneficial effect against sublesional bone loss following SCI in rats, at least in part.	Curcumin	31-39	catenin beta 1	Rattus norvegicus	97-109
26300394-9	2015	Treatment of SCI rats with curcumin enhanced mRNA levels of Wnt3a, Lrp5, and ctnnb1 and upregulated protein expression of beta-catenin in distal femurs.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	77-83
26315083-3	2015	We investigated the hypothesis that the cardioprotection afforded by SP is mediated via the Wnt/glycogen synthase kinase 3beta (GSK3beta)/beta-catenin signaling pathway.	sp	69-71	catenin beta 1	Rattus norvegicus	138-150
26174235-0	2015	Resveratrol attenuates hyperoxia-induced oxidative stress, inflammation and fibrosis and suppresses Wnt/beta-catenin signalling in lungs of neonatal rats.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	104-116
26174235-9	2015	Furthermore, Wnt/beta-catenin signalling was also suppressed by resveratrol, as represented by diminished expression of lymphoid enhancer factor-1, Wnt induced signalling protein-1 and cyclin D1.	Resveratrol	64-75	catenin beta 1	Rattus norvegicus	17-29
26376629-11	2015	RESULTS: We observed an increase in nuclear localization of immunopositive labeling of beta-catenin, HO-1, and Nrf2 in all subsets of cell types in both young and aged rats in the SGZ and SVZ following NT-020 treatment.	nt-020	202-208	catenin beta 1	Rattus norvegicus	87-99
26315083-0	2015	Wnt/Glycogen Synthase Kinase 3beta/beta-catenin Signaling Activation Mediated Sevoflurane Preconditioning-induced Cardioprotection.	Sevoflurane	78-89	catenin beta 1	Rattus norvegicus	35-47
26402535-3	2015	We have hypothesized that inhibiting phosphorylation of beta-catenin and caspase 3 activity using glycogen synthase kinase 3-specific inhibitor SB216763 would attenuate microvascular hyperpermeability following HS.	SB 216763	144-152	catenin beta 1	Rattus norvegicus	56-68
26402535-15	2015	CONCLUSION: Inhibiting phosphorylation of beta-catenin and caspase 3 activity using glycogen synthase kinase 3-specific inhibitor SB216763 help regulates HS-induced microvascular hyperpermeability.	SB 216763	130-138	catenin beta 1	Rattus norvegicus	42-54
26315083-10	2015	In addition, Western blotting analysis demonstrated that the expressions of Wnt3a, phospho-GSK3beta, and beta-catenin significantly (P &lt; 0.05) increased in the I/R group, compared with the S group; and compared to I/R group, SP significantly (P &lt; 0.05) increased Wnt3a, phospho-GSK3beta, and beta-catenin expressions.	sp	228-230	catenin beta 1	Rattus norvegicus	105-117
26315083-11	2015	Pretreatment with IWP-2 significantly (P &lt; 0.05) abolished SP-induced Wnt/GSK3beta/beta-catenin signaling activation.	sp	62-64	catenin beta 1	Rattus norvegicus	86-98
26315083-12	2015	CONCLUSIONS: The results showed for thefirst time that cardioprotection afforded by SP may be mediated partly via the Wnt/GSK3beta/beta-catenin signaling pathway.	sp	84-86	catenin beta 1	Rattus norvegicus	131-143
25655087-9	2015	Taken together, the present study indicated that ALA promoted osteoblastic formation in H(2)O(2) -treated MC3T3-E1 cells and prevented OVX-induced bone loss in rats by regulating Nox4/ROS/NF-kappaB and Wnt/Lrp5/beta-catenin signaling pathways, which provided possible mechanisms of bone-protective effects in regulating osteoblastic formation and preventing bone loss.	Thioctic Acid	49-52	catenin beta 1	Rattus norvegicus	211-223
26096038-6	2015	Intrathecal application of XAV939, which acts as an inhibitor of Wnt signaling, significantly decreased the expression levels of active beta-catenin, and attenuated the rat behavioral responses to thermal and mechanical pain stimuli.	XAV939	27-33	catenin beta 1	Rattus norvegicus	136-148
25655087-8	2015	In addition, ALA might exert its bone-protective effects by activating the Wnt/Lrp5/beta-catenin signaling pathway.	Thioctic Acid	13-16	catenin beta 1	Rattus norvegicus	84-96
26165751-0	2015	Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways.	geraniol	0-8	catenin beta 1	Rattus norvegicus	62-74
26165751-7	2015	In order to delve into the anti-colitic signaling pathways, geraniol inhibited the content/expression of glycogen synthase kinase (GSK)-3beta, beta-catenin, p38 mitogen activated protein kinase (p38MAPK), and nuclear factor kappa B (NFkappaB), but upregulated that of peroxisome proliferator activated receptor gamma (PPARgamma).	geraniol	60-68	catenin beta 1	Rattus norvegicus	143-155
26165751-9	2015	SIGNIFICANCE: Geraniol in the current study improved experimental colitis partly via its antioxidant, anti-inflammatory, and immunosuppressive potentials, possibly by modulating the Wnt/GSK-3beta/beta-catenin, p38MAPK, NFkappaB, and PPARgamma signaling pathways.	geraniol	14-22	catenin beta 1	Rattus norvegicus	196-208
26550143-10	2015	In addition, DEX-induced inhibition of differentiation markers such as alkaline phosphatase (ALP), OPG, BMP-2, beta-catenin, IGF-1 and M-CSF level, and promotion of differentiation markers such as RANKL and RANK was significantly reversed in the presence of CCG.	Dexamethasone	13-16	catenin beta 1	Rattus norvegicus	111-123
26282432-9	2015	Compared with controls, H2O2 induced the upregulation of Dvl-1, beta-catenin, and c-Myc.	Hydrogen Peroxide	24-28	catenin beta 1	Rattus norvegicus	64-76
26205949-11	2015	Mechanistically, vitamin D3/5-FU co-therapy significantly decreased the expression of Wnt, beta-catenin, iNOS, COX-2 and HSP-90 and significantly increased the expression of DKK-1, TGF-beta1, TGF-betaR2, smad4 (P &lt; 0.05), in comparison with their corresponding monotherapy groups.	Cholecalciferol	17-27	catenin beta 1	Rattus norvegicus	91-103
26262991-7	2015	On the molecular level, galantamine/vildagliptin have improved the insulin (p-insulin receptor, p-Akt, GLUT4/GLUT2) and Wnt/beta-catenin (p-GSK-3beta, beta-catenin) signaling pathways.	Galantamine	24-35	catenin beta 1	Rattus norvegicus	124-136
26262991-7	2015	On the molecular level, galantamine/vildagliptin have improved the insulin (p-insulin receptor, p-Akt, GLUT4/GLUT2) and Wnt/beta-catenin (p-GSK-3beta, beta-catenin) signaling pathways.	Galantamine	24-35	catenin beta 1	Rattus norvegicus	151-163
26262991-7	2015	On the molecular level, galantamine/vildagliptin have improved the insulin (p-insulin receptor, p-Akt, GLUT4/GLUT2) and Wnt/beta-catenin (p-GSK-3beta, beta-catenin) signaling pathways.	Vildagliptin	36-48	catenin beta 1	Rattus norvegicus	124-136
26262991-7	2015	On the molecular level, galantamine/vildagliptin have improved the insulin (p-insulin receptor, p-Akt, GLUT4/GLUT2) and Wnt/beta-catenin (p-GSK-3beta, beta-catenin) signaling pathways.	Vildagliptin	36-48	catenin beta 1	Rattus norvegicus	151-163
26277514-7	2015	Sulindac also attenuated VPA-triggered p-Gsk3beta downregulation and beta-catenin upregulation in the prefrontal lobe, seahorse and cerebellum.	Sulindac	0-8	catenin beta 1	Rattus norvegicus	69-81
25257697-0	2015	Neuroprotective Role of Novel Triazine Derivatives by Activating Wnt/beta Catenin Signaling Pathway in Rodent Models of Alzheimer"s Disease.	Triazines	30-38	catenin beta 1	Rattus norvegicus	69-81
25257697-11	2015	This study also demonstrates positive involvement of the novel triazine derivatives in the Wnt/beta-catenin pathway.	Triazines	63-71	catenin beta 1	Rattus norvegicus	95-107
25257697-12	2015	Immunoblot and immunofluorescence data suggested that ratio of pGSK3/GSK3 and beta-catenin got dramatically improved after treatment with TRZ-15 and TRZ-20.	trz	138-141	catenin beta 1	Rattus norvegicus	78-90
25257697-12	2015	Immunoblot and immunofluorescence data suggested that ratio of pGSK3/GSK3 and beta-catenin got dramatically improved after treatment with TRZ-15 and TRZ-20.	trz	149-152	catenin beta 1	Rattus norvegicus	78-90
25257697-13	2015	TRZ-15 and TRZ-20 showed neuroprotection in scopolamine-induced amnesic mice and Abeta1-42-induced Alzheimer"s rat model and also activate the Wnt/beta-catenin signaling pathway.	trz	0-3	catenin beta 1	Rattus norvegicus	147-159
25257697-13	2015	TRZ-15 and TRZ-20 showed neuroprotection in scopolamine-induced amnesic mice and Abeta1-42-induced Alzheimer"s rat model and also activate the Wnt/beta-catenin signaling pathway.	trz	11-14	catenin beta 1	Rattus norvegicus	147-159
26205949-12	2015	CONCLUSIONS: Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/beta-catenin pathway, TGF-beta1 signals, iNOS, COX-2 and HSP-90.	Cholecalciferol	13-23	catenin beta 1	Rattus norvegicus	108-120
26205949-12	2015	CONCLUSIONS: Vitamin D3 and 5-FU synergise together and exhibit better anticancer effects by modulating Wnt/beta-catenin pathway, TGF-beta1 signals, iNOS, COX-2 and HSP-90.	Fluorouracil	28-32	catenin beta 1	Rattus norvegicus	108-120
26205949-11	2015	Mechanistically, vitamin D3/5-FU co-therapy significantly decreased the expression of Wnt, beta-catenin, iNOS, COX-2 and HSP-90 and significantly increased the expression of DKK-1, TGF-beta1, TGF-betaR2, smad4 (P &lt; 0.05), in comparison with their corresponding monotherapy groups.	Fluorouracil	28-32	catenin beta 1	Rattus norvegicus	91-103
25838072-8	2015	Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level.	Dihydrotestosterone	10-13	catenin beta 1	Rattus norvegicus	244-256
25838072-8	2015	Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level.	Dihydrotestosterone	10-13	catenin beta 1	Rattus norvegicus	56-68
25838072-8	2015	Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level.	Lithium Chloride	133-149	catenin beta 1	Rattus norvegicus	244-256
25838072-8	2015	Moreover, DHT decreased the levels of total and nuclear beta-catenin, an important regulator of hair growth and proliferation, while lithium chloride, a glycogen synthase kinase-3beta inhibitor, attenuated the DHT-induced downregulation of the beta-catenin level.	Dihydrotestosterone	210-213	catenin beta 1	Rattus norvegicus	244-256
25838072-10	2015	These results illustrate that DHT could shorten the duration of the hair growth cycle by initiating cell-cycle arrest, downregulating the beta-catenin level, and upregulating the TGF-beta/Smad and HSP27 level, whereas activation of mTOR by DHT could attenuate the inhibition of hair growth cycle in immortalized DPCs.	Dihydrotestosterone	30-33	catenin beta 1	Rattus norvegicus	138-150
25903395-0	2015	Chronic Ethanol-Induced Impairment of Wnt/beta-Catenin Signaling is Attenuated by PPAR-delta Agonist.	Ethanol	8-15	catenin beta 1	Rattus norvegicus	42-54
26054011-2	2015	The CCI treatment significantly induced the overall expression of beta-catenin (158 +- 6% of sham) in the ipsilateral L5 DRGs in comparison with the sham group (109 +- 4% of sham).	CCI	4-7	catenin beta 1	Rattus norvegicus	66-78
26054011-3	2015	The CCI-induced aberrant expression of beta-catenin was significantly attenuated by oral administration of diclofenac (119 +- 6% of the sham value; 10 mg/kg).	CCI	4-7	catenin beta 1	Rattus norvegicus	39-51
26054011-3	2015	The CCI-induced aberrant expression of beta-catenin was significantly attenuated by oral administration of diclofenac (119 +- 6% of the sham value; 10 mg/kg).	Diclofenac	107-117	catenin beta 1	Rattus norvegicus	39-51
26037065-0	2015	Apoptosis associated with Wnt/beta-catenin pathway leads to steroid-induced avascular necrosis of femoral head.	Steroids	60-67	catenin beta 1	Rattus norvegicus	30-42
26037065-1	2015	BACKGROUND: The objective of the current study was to establish a rat model to investigate apoptosis in steroid-induced femoral head osteonecrosis occurring via the Wnt/beta-catenin pathway.	Steroids	104-111	catenin beta 1	Rattus norvegicus	169-181
25903395-6	2015	RESULTS: EtOH broadly inhibited expression of Wnt/beta-catenin signaling-related genes, including down-regulation of Wnt1, Fzd3, Lef1, and Bcl9 throughout the post-PH time course (0 to 72 hours), and suppression of Wnt7a, Ccnd1, Fgf4, Wif1, Sfrp2, and Sfrp5 at 18- and 24-hour post-PH time points.	Ethanol	9-13	catenin beta 1	Rattus norvegicus	50-62
25963533-10	2015	Intrathecal injection of Wnt/beta-catenin pathway inhibitor IWR-1-endo and TCF4 small interfering RNA (siRNA) significantly attenuated CCI-induced mechanical allodynia and heat hyperalgesia.	CCI	135-138	catenin beta 1	Rattus norvegicus	29-41
26199613-2	2015	In this study, we initially examined the effect of rapamycin on the Wnt/beta-catenin signaling pathway after spinal cord injury, by intraperitoneally injecting spinal cord injured rats with rapamycin over 2 days.	Sirolimus	51-60	catenin beta 1	Rattus norvegicus	72-84
26199613-2	2015	In this study, we initially examined the effect of rapamycin on the Wnt/beta-catenin signaling pathway after spinal cord injury, by intraperitoneally injecting spinal cord injured rats with rapamycin over 2 days.	Sirolimus	190-199	catenin beta 1	Rattus norvegicus	72-84
26111684-6	2015	The dose of propofol was inversely correlated with the number of metastasis tumor foci (r=-0.879) and expressions of E-cadherin (r=-0.755) and beta-catenin (r=-0.693) (P&lt;0.01).	Propofol	12-20	catenin beta 1	Rattus norvegicus	143-155
26199613-4	2015	Rapamycin increased the levels of beta-catenin and brain-derived neurotrophic factor in the injured spinal cord, improved the pathological morphology at the injury site, reduced the loss of motor neurons, and promoted motor functional recovery in rats after spinal cord injury.	Sirolimus	0-9	catenin beta 1	Rattus norvegicus	34-46
26111684-7	2015	CONCLUSION: Propofol can dose-dependently suppress pulmonary metastasis of intravenous injected MADB106 tumor cells by inhibiting the Wnt/beta-catenin pathway and down-regulating E-cadherin and beta-catenin expressions in the metastatic tumor tissue.	Propofol	12-20	catenin beta 1	Rattus norvegicus	138-150
25873562-0	2015	Flutamide alters the distribution of c-Src and affects the N-cadherin-beta-catenin complex in the seminiferous epithelium of adult rat.	Flutamide	0-9	catenin beta 1	Rattus norvegicus	70-82
26111684-7	2015	CONCLUSION: Propofol can dose-dependently suppress pulmonary metastasis of intravenous injected MADB106 tumor cells by inhibiting the Wnt/beta-catenin pathway and down-regulating E-cadherin and beta-catenin expressions in the metastatic tumor tissue.	Propofol	12-20	catenin beta 1	Rattus norvegicus	194-206
26255484-0	2015	[Effects of serum of Bushen Huoxue prescription (Chinese characters) on classic Wnt/beta-catenin signaling pathways of osteoblasts].	huoxue	28-34	catenin beta 1	Rattus norvegicus	84-96
26255484-14	2015	The expression of mRNA of beta-catenin, Runx2 and Osx in Bushen Huoxue (Chinese characters)group were (1.782+-0.944), (1.935+-0.994) and (1.610+-0.811) by RT-PCR,it was significantly increased compared with saline group (P&lt;0.01), but there was no difference between Bushen Huoxue (Chinese characters)group and normal group (P&gt;0.05).	Sodium Chloride	207-213	catenin beta 1	Rattus norvegicus	26-38
25873562-1	2015	This study was undertaken to explore interactions between c-Src kinase and the N-cadherin-beta-catenin complex in seminiferous tubules of flutamide-treated rats.	Flutamide	138-147	catenin beta 1	Rattus norvegicus	90-102
25873562-7	2015	As we used an exposure regime which avoided germ cell loss, it is likely that changes in the N-cadherin-beta-catenin complex are a primary effect of androgen signaling disruption by flutamide.	Flutamide	182-191	catenin beta 1	Rattus norvegicus	104-116
25873562-11	2015	Overall, for the first time we have shown that flutamide alters the distribution of c-Src and affects N-cadherin-beta-catenin interactions at the BTB.	Flutamide	47-56	catenin beta 1	Rattus norvegicus	113-125
25867402-0	2015	Impact and significance of EGCG on Smad, ERK, and beta-catenin pathways in transdifferentiation of renal tubular epithelial cells.	epigallocatechin gallate	27-31	catenin beta 1	Rattus norvegicus	50-62
25847511-6	2015	Moreover, we found that beta-catenin activity was suppressed during apoptosis and that beta-catenin inhibition was crucial for potassium deprivation-induced neuronal apoptosis.	Potassium	127-136	catenin beta 1	Rattus norvegicus	87-99
26121856-10	2015	PPS increased the expression of SFRP1, 2 and decreased the expression of beta-catenin, C-myc, ccndl and fibronectin in the RA rats.	Pentosan Sulfuric Polyester	0-3	catenin beta 1	Rattus norvegicus	73-85
25867402-9	2015	EGCG may be helpful for maintaining the renal tubular epithelial cell phenotype and reducing the degree of TGF-b1- induced cell transdifferentiation, which may be related to the signal transduction pathway of ERK, Smad3, and beta-catenin.	epigallocatechin gallate	0-4	catenin beta 1	Rattus norvegicus	225-237
25187349-10	2015	This potentially indicates that sFRP-1 is a major regulator of defective Wnt/beta-catenin signalling following MTX treatment.	Methotrexate	111-114	catenin beta 1	Rattus norvegicus	77-89
25661318-11	2015	In rats with a partial hepatectomy, administration of SB216763 (2 mg/kg, ip) significantly increased the number of oval cells, the levels of phospho-Ser9-GSK-3beta, beta-catenin and cyclin D1 in liver, as well as the ratio of liver weight to femur length at d 7 after the surgery.	SB 216763	54-62	catenin beta 1	Rattus norvegicus	165-177
25326587-1	2015	AZD7969 is a potent inhibitor of glycogen synthase kinase 3 (GSK3beta), which is a multifunctional serine/threonine kinase that negatively regulates the Wnt/beta-catenin signaling pathway.	azd7969	0-7	catenin beta 1	Rattus norvegicus	157-169
25187349-0	2015	Methotrexate-induced bone marrow adiposity is mitigated by folinic acid supplementation through the regulation of Wnt/beta-catenin signalling.	Methotrexate	0-12	catenin beta 1	Rattus norvegicus	118-130
25187349-0	2015	Methotrexate-induced bone marrow adiposity is mitigated by folinic acid supplementation through the regulation of Wnt/beta-catenin signalling.	Leucovorin	59-71	catenin beta 1	Rattus norvegicus	118-130
25514428-3	2015	We therefore hypothesized that pharmacological activation of the Wnt/beta-catenin signaling by the Wnt agonist, a synthetic pyrimidine, could protect kidneys from IRI.	pyrimidine	124-134	catenin beta 1	Rattus norvegicus	69-81
25187349-5	2015	As the Wnt/beta-catenin signalling pathway is critical for commitment and differentiation of mesenchymal stem cells down the osteogenic or adipogenic lineage, its deregulation has been found associated with increased marrow adiposity following MTX treatment.	Methotrexate	244-247	catenin beta 1	Rattus norvegicus	11-23
25353064-0	2015	Cyclosporine A enhances gingival beta-catenin stability via Wnt signaling.	Cyclosporine	0-14	catenin beta 1	Rattus norvegicus	33-45
25353064-1	2015	BACKGROUND: Cyclosporine A (CsA) increases beta-catenin messenger RNA (mRNA) and protein expression.	Cyclosporine	12-26	catenin beta 1	Rattus norvegicus	43-55
25353064-1	2015	BACKGROUND: Cyclosporine A (CsA) increases beta-catenin messenger RNA (mRNA) and protein expression.	Cyclosporine	28-31	catenin beta 1	Rattus norvegicus	43-55
25353064-9	2015	RESULTS: In rats treated with CsA, overgrowth of gingivae was observed, and altered expression of genes related to Wnt/beta-catenin signaling was detected by the microarray.	Cyclosporine	30-33	catenin beta 1	Rattus norvegicus	119-131
25353064-10	2015	The gingival mRNA and protein expression profiles for genes associated with Wnt/beta-catenin signaling further confirmed the effect of CsA: beta-catenin and Dvl-1 expression increased, but APC and axin-1 expression decreased.	Cyclosporine	135-138	catenin beta 1	Rattus norvegicus	80-92
25353064-10	2015	The gingival mRNA and protein expression profiles for genes associated with Wnt/beta-catenin signaling further confirmed the effect of CsA: beta-catenin and Dvl-1 expression increased, but APC and axin-1 expression decreased.	Cyclosporine	135-138	catenin beta 1	Rattus norvegicus	140-152
25353064-11	2015	Western blotting and immunohistochemistry showed decreases in beta-catenin serine phosphorylation (33/37) and ubiquitinylation in the gingivae of CsA-treated rats.	Cyclosporine	146-149	catenin beta 1	Rattus norvegicus	62-74
25353064-12	2015	CONCLUSION: CsA-enhanced gingival beta-catenin stability may be involved in gene upregulation or beta-catenin degradation via the Wnt/beta-catenin pathway.	Cyclosporine	12-15	catenin beta 1	Rattus norvegicus	34-46
25353064-12	2015	CONCLUSION: CsA-enhanced gingival beta-catenin stability may be involved in gene upregulation or beta-catenin degradation via the Wnt/beta-catenin pathway.	Cyclosporine	12-15	catenin beta 1	Rattus norvegicus	97-109
25353064-12	2015	CONCLUSION: CsA-enhanced gingival beta-catenin stability may be involved in gene upregulation or beta-catenin degradation via the Wnt/beta-catenin pathway.	Cyclosporine	12-15	catenin beta 1	Rattus norvegicus	97-109
25427908-5	2015	In the EtOH+DEN group, tumor multiplicity corresponded to a 3- to 4-fold increase in proliferation and immunohistochemical staining of beta-catenin in non-tumorigenic hepatocytes when compared to the PF+DEN and chow+DEN groups, p&lt;0.05.	Ethanol	7-11	catenin beta 1	Rattus norvegicus	135-147
25229877-6	2015	The anti-apoptosis action of BMSCs was reversed by SB216763, a specific inhibitor of GSK-3beta that also activates Wnt/beta-catenin signaling.	SB 216763	51-59	catenin beta 1	Rattus norvegicus	119-131
25618407-9	2015	Lithium treatment normalized the Tert expression and telomerase activity in the Flinders Sensitive Line and upregulated beta-catenin.	Lithium	0-7	catenin beta 1	Rattus norvegicus	120-132
25427908-7	2015	These data suggest that chronic EtOH consumption activates the Wnt/beta-catenin signaling pathway, which increases hepatocyte proliferation thus promoting tumorigenesis following an initiating insult in the liver.	Ethanol	32-36	catenin beta 1	Rattus norvegicus	67-79
25427908-5	2015	In the EtOH+DEN group, tumor multiplicity corresponded to a 3- to 4-fold increase in proliferation and immunohistochemical staining of beta-catenin in non-tumorigenic hepatocytes when compared to the PF+DEN and chow+DEN groups, p&lt;0.05.	Diethylnitrosamine	12-15	catenin beta 1	Rattus norvegicus	135-147
25634106-0	2015	High phosphorus level leads to aortic calcification via beta-catenin in chronic kidney disease.	Phosphorus	5-15	catenin beta 1	Rattus norvegicus	56-68
25634106-14	2015	CONCLUSION: These results suggest that beta-catenin is an important player in high phosphorus level-induced aortic calcification in CKD.	Phosphorus	83-93	catenin beta 1	Rattus norvegicus	39-51
26609522-6	2015	RESULTS: beta-GP induced an increase in the expression of BMP2, Runx2, and beta-catenin.	beta-gp	9-16	catenin beta 1	Rattus norvegicus	75-87
26135564-0	2015	Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.	Glucagon	0-8	catenin beta 1	Rattus norvegicus	38-50
26135564-0	2015	Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.	Serine	24-30	catenin beta 1	Rattus norvegicus	38-50
26135564-5	2015	In this study, we aimed to identify the effect of glucagon on beta-catenin in the isolated rat liver.	Glucagon	50-58	catenin beta 1	Rattus norvegicus	62-74
26544628-6	2015	Next, we used qPCR and Western blotting to detect the effect of a high concentration of dexamethasone on molecules related to the canonical WNT/beta-catenin pathway in TSCs.	Dexamethasone	88-101	catenin beta 1	Rattus norvegicus	144-156
26418252-11	2015	Further exploration of the molecular mechanism indicated that ZXHA-C activated the Wnt/beta-catenin signal pathway in chondrocytes, as evidenced by up-regulated gene expression of beta-catenin, Wnt-4, cyclin D1 and Frizzled-2 and decreased glycogen synthase kinase 3beta (GSK-3beta).	zxha-c	62-68	catenin beta 1	Rattus norvegicus	87-99
26544628-8	2015	Western blotting results further showed that Dex downregulated the cellular signaling molecule phosphorylated glycogen synthase kinase-3beta (P-GSK-3 beta (ser9)), upregulated P-GSK-3beta (tyr216), and downregulated the pivotal signaling molecule beta-catenin.	Dexamethasone	45-48	catenin beta 1	Rattus norvegicus	247-259
26418252-11	2015	Further exploration of the molecular mechanism indicated that ZXHA-C activated the Wnt/beta-catenin signal pathway in chondrocytes, as evidenced by up-regulated gene expression of beta-catenin, Wnt-4, cyclin D1 and Frizzled-2 and decreased glycogen synthase kinase 3beta (GSK-3beta).	zxha-c	62-68	catenin beta 1	Rattus norvegicus	180-192
26544628-9	2015	Furthermore, DKK1 knockdown attenuated Dex-induced inhibition of the canonical WNT/beta-catenin pathway and of the adipogenic differentiation of TSCs.	Dexamethasone	39-42	catenin beta 1	Rattus norvegicus	83-95
26544628-10	2015	Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	99-111
26544628-10	2015	Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes.	Lithium Chloride	18-22	catenin beta 1	Rattus norvegicus	99-111
26544628-10	2015	Lithium chloride (LiCl, a GSK-3beta inhibitor) reduced Dex-induced inhibition of the classical WNT/beta-catenin pathway in TSCs and of the differentiation of TSCs to adipocytes.	Dexamethasone	55-58	catenin beta 1	Rattus norvegicus	99-111
26544628-11	2015	CONCLUSION: In conclusion, by upregulating DKK1 expression, reducing the level of P-GSK-3beta (ser9), and increasing the level of P-GSK-3beta (tyr216), Dex causes the degradation of beta-catenin, the central molecule of the classical WNT pathway, thereby inducing rat TSCs to differentiate into adipocytes.	Dexamethasone	152-155	catenin beta 1	Rattus norvegicus	182-194
26159568-4	2015	RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors.	naringin	9-17	catenin beta 1	Rattus norvegicus	63-75
26159568-4	2015	RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors.	naringin	9-17	catenin beta 1	Rattus norvegicus	116-128
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	dorsomorphin	115-127	catenin beta 1	Rattus norvegicus	166-178
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	dorsomorphin	115-127	catenin beta 1	Rattus norvegicus	226-238
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	catenin beta 1	Rattus norvegicus	166-178
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	catenin beta 1	Rattus norvegicus	226-238
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	catenin beta 1	Rattus norvegicus	166-178
26279449-15	2015	CONCLUSIONS: Our data suggested that Osthole increases the catabolism of rat chondrocytes and cartilage explants, this effect might be mediated through inhibiting Wnt7b/beta-catenin pathway.	osthol	37-44	catenin beta 1	Rattus norvegicus	169-181
25033705-8	2014	Furthermore, cells in the IWR1-treated group showed decreased wnt3a and beta-catenin expression, and wnt3a and beta-catenin was also decreased in the IWR1 + 500 nmol/L curcumin group.	Curcumin	168-176	catenin beta 1	Rattus norvegicus	111-123
25452781-9	2015	Additionally, Rac1 activation was required for the high glucose-induced VE-cadherin expression decrease and for beta-catenin expression in high glucose-induced RRECs.	Glucose	144-151	catenin beta 1	Rattus norvegicus	112-124
25339460-12	2015	In conclusion, the possible mechanism of selenium deficiency-induced cardiac dysfunction was associated with the Wnt/beta-catenin signaling pathway.	Selenium	41-49	catenin beta 1	Rattus norvegicus	117-129
25707134-6	2015	CONCLUSION: Dutasteride can significantly inhibit the fertility of male rats by reducing the serum DHT level, suppressing Claudin1 and beta-catenin expressions, and damaging epididymal epithelial cell junctions.	Dutasteride	12-23	catenin beta 1	Rattus norvegicus	135-147
25674206-10	2014	It was also canceled by overexpressing Dvl-1 that the decrease of beta-catenin protein treated with atorvastatin in cells exposed to AngII.	Atorvastatin	100-112	catenin beta 1	Rattus norvegicus	66-78
25384498-8	2015	The results from the present study demonstrate that the antioxidant properties of sulindac may prove to be beneficial in the treatment of autism, suggesting that the upregulation of the Wnt/beta-catenin signaling pathway disrupts oxidative homeostasis and facilitates susceptibility to autism.	Sulindac	82-90	catenin beta 1	Rattus norvegicus	190-202
25707134-0	2015	[Inhibitory effect of dutasteride on the expressions of epididymal Claudin1 and beta-catenin in male rats].	Dutasteride	22-33	catenin beta 1	Rattus norvegicus	80-92
25707134-1	2015	OBJECTIVE: To explore the molecular mechanism of dutasteride inhibiting fertility by studying its effects on the expressions of the epididymal epithelial junction proteins Claudin1 and beta-catenin in rats.	Dutasteride	49-60	catenin beta 1	Rattus norvegicus	185-197
25033705-7	2014	RESULTS: Western-blotting: after the third generation of cells had been treated for 72 h, we observed that wnt3a and beta-catenin expression was significantly increased in the group receiving 500 nmol/L curcumin but not in the other groups.	Curcumin	203-211	catenin beta 1	Rattus norvegicus	117-129
25169829-7	2014	RESULTS: Hinokitiol inhibited IL-1beta-stimulated MMP-1,-3 and -13 expressions and IL-1beta-induced activation of intracellular beta-catenin proteins in cultured chondrocytes.	beta-thujaplicin	9-19	catenin beta 1	Rattus norvegicus	128-140
25375224-0	2014	The role of Wnt/beta-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat.	Methotrexate	69-81	catenin beta 1	Rattus norvegicus	16-28
25375224-3	2014	In the present study, we tested whether Wnt/beta-catenin signaling is involved in methotrexate (MTX)-induced intestinal damage in a rat model.	Methotrexate	82-94	catenin beta 1	Rattus norvegicus	44-56
25375224-3	2014	In the present study, we tested whether Wnt/beta-catenin signaling is involved in methotrexate (MTX)-induced intestinal damage in a rat model.	Methotrexate	96-99	catenin beta 1	Rattus norvegicus	44-56
25375224-12	2014	Four days following MTX administration, rats demonstrated a trend toward a restoration of Wnt/beta-catenin signaling especially in ileum.	Methotrexate	20-23	catenin beta 1	Rattus norvegicus	94-106
25375224-13	2014	CONCLUSIONS: Wnt/beta-catenin signaling is involved in enterocyte turnover during MTX-induced intestinal mucositis in a rat.	Methotrexate	82-85	catenin beta 1	Rattus norvegicus	17-29
25169829-9	2014	CONCLUSIONS: Hinokitiol is an effective anti-inflammatory reagent that acts by inhibiting the Wnt/beta-catenin signaling pathway and could be a promising therapeutic agent for the prevention and treatment of osteoarthritis.	beta-thujaplicin	13-23	catenin beta 1	Rattus norvegicus	98-110
24945564-0	2014	Curcumin affects beta-catenin pathway in hepatic stellate cell in vitro and in vivo.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	17-29
24945564-4	2014	This study is aimed to examine whether curcumin affects beta-catenin expression/activity in HSCs and explores the underlying mechanisms.	Curcumin	39-47	catenin beta 1	Rattus norvegicus	56-68
24945564-6	2014	KEY FINDINGS: Results showed that curcumin could reduce beta-catenin protein level in HSCs in vitro and in vivo.	Curcumin	34-42	catenin beta 1	Rattus norvegicus	56-68
24945564-7	2014	Both beta-catenin transactivation activity and DNA-binding activity were suppressed by curcumin.	Curcumin	87-95	catenin beta 1	Rattus norvegicus	5-17
24945564-8	2014	Moreover, nuclear beta-catenin protein level was decreased by curcumin treatment.	Curcumin	62-70	catenin beta 1	Rattus norvegicus	18-30
24945564-9	2014	Further experiments suggested that delta-like homologue 1 contributed to curcumin inhibition of beta-catenin transactivation activity in cultured HSCs.	Curcumin	73-81	catenin beta 1	Rattus norvegicus	96-108
24945564-10	2014	CONCLUSIONS: Curcumin affects beta-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.	Curcumin	13-21	catenin beta 1	Rattus norvegicus	30-42
24945564-10	2014	CONCLUSIONS: Curcumin affects beta-catenin pathway in HSCs and might suggest a possible new explanation for the effects of curcumin on HSC activation and liver fibrosis.	Curcumin	123-131	catenin beta 1	Rattus norvegicus	30-42
25432370-9	2014	CONCLUSION: Minocycline can alleviate the ischemic-reperfusion injury mainly through reducing oxidative stress and inhibiting the release of pro-inflammatory cytokines depends on the activation of the Wnt/beta-catenin signaling pathway in the liver.	Minocycline	12-23	catenin beta 1	Rattus norvegicus	205-217
25456852-8	2014	Furthermore, curcumin inhibited HG-induced caveolin-1 (cav-1) Tyr(14) phosphorylation associating with the suppression of stabilization of cav-1 and beta-catenin.	Curcumin	13-21	catenin beta 1	Rattus norvegicus	149-161
25456852-5	2014	And we investigated the effect of curcumin on HG-induced phosphorylation of cav-1 on the stability cav-1 and beta-catenin using immunoprecipitation and fluorescence microscopy analysis.	Curcumin	34-42	catenin beta 1	Rattus norvegicus	109-121
25456852-9	2014	CONCLUSIONS: In summary, these findings suggest that curcumin prevents EMT of podocytes, proteinuria, and kidney injury in DN by suppressing the phosphorylation of cav-1, and increasing stabilization of cav-1 and beta-catenin.	Curcumin	53-61	catenin beta 1	Rattus norvegicus	213-225
24861203-5	2014	In this study, we found that XAV939, a small-molecular inhibitor that stimulated beta-catenin degradation by stabilizing axin, protected against serum and glucose deprivation (SGD)-induced cell death in oligodentrocyte cell line OLN-93 cells in a concentration-dependent manner.	XAV939	29-35	catenin beta 1	Rattus norvegicus	81-93
24875644-11	2014	KC and KC+B upregulated low-density lipoprotein receptor-related protein 5 and beta-catenin in OVX rats, but suppressed the expression of dickkopf-related protein 1.	kc+b	7-11	catenin beta 1	Rattus norvegicus	79-91
25612449-0	2014	[Effect of total glucosides of paeony on Wnt/beta-catenin signal transduction pathway expression in kidney of diabetic rats].	Glucosides	17-27	catenin beta 1	Rattus norvegicus	45-57
25612449-1	2014	The study is to explore the effect of total glucosides of paeony (TGP)on Wnt/beta-catenin signal transduction pathway expression in kidney of diabetic rats, and discuss the protection of TGP in diabetic nephropathy and possible mechanism.	Glucosides	44-54	catenin beta 1	Rattus norvegicus	77-89
25612449-1	2014	The study is to explore the effect of total glucosides of paeony (TGP)on Wnt/beta-catenin signal transduction pathway expression in kidney of diabetic rats, and discuss the protection of TGP in diabetic nephropathy and possible mechanism.	tgp	66-69	catenin beta 1	Rattus norvegicus	77-89
25612449-12	2014	The Result show that Wnt-1 and beta-catenin expression increased in kidney of high-fat high-sugar induced type 2 diabetic rats.	Sugars	92-97	catenin beta 1	Rattus norvegicus	31-43
24876057-4	2014	The aim of the present study is to test whether morroniside promotes neurogenesis via Wnt/beta-catenin signaling pathway for brain recovery in a rat model of focal cerebral ischemia.	morroniside	48-59	catenin beta 1	Rattus norvegicus	90-102
24950409-5	2014	There was no direct effect of Li2CO3 on Akt1-induced phosphorylation of GSK-3beta at Ser9, but otherwise Li2CO3 significantly reduced GSK-3beta-mediated phosphorylation of beta-catenin at Ser33/37 and Thr41.	Lithium Carbonate	105-111	catenin beta 1	Rattus norvegicus	172-184
25176207-11	2014	CONCLUSION: High glucose can inhibit the proliferation of bone marrow stormal cells by suppressing the expressions of Beta-catenin, LEF-1, and cyclin D1 in the Wnt/Beta-catenin pathway.	Glucose	17-24	catenin beta 1	Rattus norvegicus	118-130
25176207-11	2014	CONCLUSION: High glucose can inhibit the proliferation of bone marrow stormal cells by suppressing the expressions of Beta-catenin, LEF-1, and cyclin D1 in the Wnt/Beta-catenin pathway.	Glucose	17-24	catenin beta 1	Rattus norvegicus	164-176
22987596-5	2014	Developmental hypothyroidism induced by iodine deficiency and PTU treatment delayed the maturation of hippocampal granule neurons in the offspring and decreased the percentage of Dcx-positive neurons that expressed beta-catenin on postnatal day 21 and 28.	Phenylthiourea	62-65	catenin beta 1	Rattus norvegicus	215-227
22987596-5	2014	Developmental hypothyroidism induced by iodine deficiency and PTU treatment delayed the maturation of hippocampal granule neurons in the offspring and decreased the percentage of Dcx-positive neurons that expressed beta-catenin on postnatal day 21 and 28.	dcx	179-182	catenin beta 1	Rattus norvegicus	215-227
25176207-0	2014	[Observing the effect of high glucose on proliferation of bone marrow stromal stem cells through Wnt/Beta-catenin pathway].	Glucose	30-37	catenin beta 1	Rattus norvegicus	101-113
25176207-1	2014	OBJECTIVE: To explore the effect of high glucose on proliferation of bone marrow stromal stem cells through Wnt/Beta-catenin pathway.	Glucose	41-48	catenin beta 1	Rattus norvegicus	112-124
24950409-7	2014	In rat hippocampal slices Li2CO3 significantly inhibited phosphorylation of Akt1/2 at Ser473/474, GSK-3beta at Ser9, and beta-catenin at Ser33/37 and Thr41.	Lithium Carbonate	26-32	catenin beta 1	Rattus norvegicus	121-133
25024745-14	2014	Furthermore, Mocetinostat increased E-cadherin, induced beta-catenin localization to the membrane, and reduced Akt/GSK3beta signaling in atrial cardiac fibroblasts.	mocetinostat	13-25	catenin beta 1	Rattus norvegicus	56-68
24891510-8	2014	In cultured rat neonatal cardiomyocytes, calpain activation by treatment with ionomycin induced cleavage of N-cadherin and decreased expression levels of beta-catenin and connexin 43, which was attenuated by calpain inhibitor.	Ionomycin	78-87	catenin beta 1	Rattus norvegicus	154-166
24721324-0	2014	Piroxicam and c-phycocyanin prevent colon carcinogenesis by inhibition of membrane fluidity and canonical Wnt/beta-catenin signaling while up-regulating ligand dependent transcription factor PPARgamma.	Piroxicam	0-9	catenin beta 1	Rattus norvegicus	110-122
25001136-5	2014	The expression for beta-catenin mRNA in AGE and hyperglycemia was also decreased by 59.6% at 24 hours, compared with that of normal glucose conditions (P = .01).	Glucose	132-139	catenin beta 1	Rattus norvegicus	19-31
24721324-9	2014	We conclude that piroxicam and c-phycocyanin exert their anti-neoplastic effects via regulating membrane properties, raising calpain-9 and PPARgamma expression while suppressing Wnt/beta-catenin signaling in experimental colon carcinogenesis.	Piroxicam	17-26	catenin beta 1	Rattus norvegicus	182-194
24992763-0	2014	Huogu I formula prevents steroid-induced osteonecrosis in rats by down-regulating PPARgamma expression and activating wnt/LRP5/ beta-catenin signaling.	Steroids	25-32	catenin beta 1	Rattus norvegicus	128-140
24464479-0	2014	Downregulation of the Wnt/beta-catenin signaling pathway is involved in manganese-induced neurotoxicity in rat striatum and PC12 cells.	Manganese	72-81	catenin beta 1	Rattus norvegicus	26-38
24464479-11	2014	More importantly, blockage of GSK-3beta activity with the GSK-3beta inhibitor lithium chloride could attenuate Mn-induced downregulation of beta-catenin and survivin as well as neuronal apoptosis.	Lithium Chloride	78-94	catenin beta 1	Rattus norvegicus	140-152
24718323-9	2014	beta-catenin degradation was downregulated by matrine and rapamycin, a foregone chemical agonist of autophagy, whereas it was upregulated by 3-methyladenine, a specific inhibitor of autophagy.	3-methyladenine	141-156	catenin beta 1	Rattus norvegicus	0-12
24691643-5	2014	To inhibit the Wnt/beta-catenin signaling pathway, siRNA for beta-catenin was developed and transiently transfected into HSC-T6 cells using Lipofectamine 2000.	Lipofectamine	140-158	catenin beta 1	Rattus norvegicus	61-73
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	catenin beta 1	Rattus norvegicus	113-125
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	catenin beta 1	Rattus norvegicus	262-274
24657224-0	2014	Wnt/beta-catenin signaling pathway and lipolysis enzymes participate in methylprednisolone induced fat differential distribution between subcutaneous and visceral adipose tissue.	Methylprednisolone	72-90	catenin beta 1	Rattus norvegicus	4-16
24657224-6	2014	In the present study, we measured fat depot masses and the expression of Wnt/beta-catenin signaling pathway and lipolytic enzymes of female Sprague-Dawley rats treated with or without methylprednisolone.	Methylprednisolone	184-202	catenin beta 1	Rattus norvegicus	77-89
24757104-0	2014	Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1alpha/beta-catenin pathway in middle cerebral artery occlusion rats.	Oxygen	19-25	catenin beta 1	Rattus norvegicus	120-132
24657224-8	2014	Our data suggested that methylprednisolone could inhibit Wnt/beta-catenin signaling pathway in SAT and VAT, increase the expression of ATGL and HSL in SAT, and decrease the expression of ATGL and HSL in VAT.	Methylprednisolone	24-42	catenin beta 1	Rattus norvegicus	61-73
24757104-0	2014	Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1alpha/beta-catenin pathway in middle cerebral artery occlusion rats.	Reactive Oxygen Species	64-87	catenin beta 1	Rattus norvegicus	120-132
24658359-10	2014	Intraarticular injection of verapamil inhibited OA progression as well as nuclear localizations of beta-catenin in a rat OA model.	Verapamil	28-37	catenin beta 1	Rattus norvegicus	99-111
24757104-12	2014	CONCLUSIONS: Delayed HBO enhanced endogenous neurogenesis and improved neurofunctional recovery in the late-chronic phase of stroke possibly mediated by ROS/HIF-1alpha/beta-catenin pathway.	Reactive Oxygen Species	153-156	catenin beta 1	Rattus norvegicus	168-180
24603008-8	2014	These posttraining changes in hippocampal p-GSK-3beta and p-beta-catenin were blocked by injection of 100mg/kg ketamine immediately after training, indicating that the 100mg/kg dose of ketamine altered activation of GSK3beta/beta-catenin signaling pathway in the hippocampus.	Ketamine	111-119	catenin beta 1	Rattus norvegicus	60-72
24603008-8	2014	These posttraining changes in hippocampal p-GSK-3beta and p-beta-catenin were blocked by injection of 100mg/kg ketamine immediately after training, indicating that the 100mg/kg dose of ketamine altered activation of GSK3beta/beta-catenin signaling pathway in the hippocampus.	Ketamine	111-119	catenin beta 1	Rattus norvegicus	225-237
24603008-8	2014	These posttraining changes in hippocampal p-GSK-3beta and p-beta-catenin were blocked by injection of 100mg/kg ketamine immediately after training, indicating that the 100mg/kg dose of ketamine altered activation of GSK3beta/beta-catenin signaling pathway in the hippocampus.	Ketamine	185-193	catenin beta 1	Rattus norvegicus	60-72
24603008-8	2014	These posttraining changes in hippocampal p-GSK-3beta and p-beta-catenin were blocked by injection of 100mg/kg ketamine immediately after training, indicating that the 100mg/kg dose of ketamine altered activation of GSK3beta/beta-catenin signaling pathway in the hippocampus.	Ketamine	185-193	catenin beta 1	Rattus norvegicus	225-237
24603008-9	2014	Acute injection of the GSK3beta specific inhibitor SB216763 (1 ng/0.5 mul/side) into area CA1 of the hippocampus after water maze training prevented ketamine-induced impairment of memory and blocked ketamine-induced effects on the GSK3beta/beta-catenin signaling pathway in the hippocampus.	SB 216763	51-59	catenin beta 1	Rattus norvegicus	240-252
24603008-10	2014	Our results suggest that an anesthetic dose of ketamine injected immediately after Morris water maze training impaired memory consolidation and support the hypothesis that GSK3beta/beta-catenin signaling may play a role in ketamine-induced retrograde amnesia.	Ketamine	47-55	catenin beta 1	Rattus norvegicus	181-193
24603008-10	2014	Our results suggest that an anesthetic dose of ketamine injected immediately after Morris water maze training impaired memory consolidation and support the hypothesis that GSK3beta/beta-catenin signaling may play a role in ketamine-induced retrograde amnesia.	Ketamine	223-231	catenin beta 1	Rattus norvegicus	181-193
24643679-0	2014	The Wnt/beta-catenin signaling pathway is involved in the antitumor effect of fulvestrant on rat prolactinoma MMQ cells.	Fulvestrant	78-89	catenin beta 1	Rattus norvegicus	8-20
24643679-10	2014	Antitumor effect of fulvestrant was partially disrupted by SB 216763 via activation of the Wnt/beta-catenin pathway.	Fulvestrant	20-31	catenin beta 1	Rattus norvegicus	95-107
24643679-10	2014	Antitumor effect of fulvestrant was partially disrupted by SB 216763 via activation of the Wnt/beta-catenin pathway.	SB 216763	59-68	catenin beta 1	Rattus norvegicus	95-107
24610920-14	2014	We showed an increase of phosphorylated glycogen synthase kinase-3beta, which is phosphorylated by activated MAPKs and inhibits beta-catenin degradation, was attenuated by olmesartan.	olmesartan	172-182	catenin beta 1	Rattus norvegicus	128-140
24610920-16	2014	Olmesartan might be a new upstream arrhythmia therapy by modulating intercellular junction remodeling through the beta-catenin signaling pathway.	olmesartan	0-10	catenin beta 1	Rattus norvegicus	114-126
24603008-0	2014	Involvement of GSK3beta/beta-catenin signaling in the impairment effect of ketamine on spatial memory consolidation in rats.	Ketamine	75-83	catenin beta 1	Rattus norvegicus	24-36
24603008-7	2014	Western blots showed that p-GSK-3beta(Ser9) levels were reduced and p-beta-catenin(Ser33/37/Thr41) levels were elevated in ketamine treated rats during consolidation.	Ketamine	123-131	catenin beta 1	Rattus norvegicus	70-82
24510055-10	2014	Importantly, pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats.	Pravastatin	13-24	catenin beta 1	Rattus norvegicus	160-172
24596384-7	2014	In vivo studies were performed to assess the anticancer effect of quinuclidinone 2 on N-Nitroso-N-methylurea-induced breast cancer in female rats by evaluating physiological processes and the expression levels of beta-catenin and E-cadherin.	1-azabicyclo[2.2.2]octan-2-one	66-80	catenin beta 1	Rattus norvegicus	213-225
24510055-10	2014	Importantly, pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats.	Steroids	49-56	catenin beta 1	Rattus norvegicus	160-172
24211784-0	2014	Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3beta and beta-catenin pathway.	Valproic Acid	0-9	catenin beta 1	Rattus norvegicus	155-167
23779049-7	2014	Treatment with GW 501516 increased adipose tissue HO-1 and adiponectin levels (P&lt;0.01) along with enhancement of Wnt10b and beta-catenin expression.	glycyltryptophan	15-17	catenin beta 1	Rattus norvegicus	127-139
24300170-0	2014	Fluoride promotes osteoblastic differentiation through canonical Wnt/beta-catenin signaling pathway.	Fluorides	0-8	catenin beta 1	Rattus norvegicus	69-81
24300170-4	2014	The current study determined the involvement of Wnt/beta-catenin signaling in fluoride-induced osteoblastic differentiation.	Fluorides	78-86	catenin beta 1	Rattus norvegicus	52-64
24300170-6	2014	We further found fluoride induced phosphorylations at serine 473 of Akt and serine 9 of glycogen synthase kinase-3beta (GSK3beta), which resulted in GSK-3beta inhibition and subsequently the nuclear accumulation of the beta-catenin, as shown by Western blot and immunofluorescence analysis.	Fluorides	17-25	catenin beta 1	Rattus norvegicus	219-231
24300170-6	2014	We further found fluoride induced phosphorylations at serine 473 of Akt and serine 9 of glycogen synthase kinase-3beta (GSK3beta), which resulted in GSK-3beta inhibition and subsequently the nuclear accumulation of the beta-catenin, as shown by Western blot and immunofluorescence analysis.	Serine	54-60	catenin beta 1	Rattus norvegicus	219-231
24300170-6	2014	We further found fluoride induced phosphorylations at serine 473 of Akt and serine 9 of glycogen synthase kinase-3beta (GSK3beta), which resulted in GSK-3beta inhibition and subsequently the nuclear accumulation of the beta-catenin, as shown by Western blot and immunofluorescence analysis.	Serine	76-82	catenin beta 1	Rattus norvegicus	219-231
24300170-8	2014	Importantly, the positive effect of fluoride on ALP activity and mRNA expressions of COL1A1, ALP, osteonection and Runx2 was abolished by DKK-1, a blocker of the Wnt/beta-catenin receptor.	Fluorides	36-44	catenin beta 1	Rattus norvegicus	166-178
24300170-9	2014	Taken together, these findings suggest that fluoride promotes osteoblastic differentiation through Akt- and GSK-3beta-dependent activation of Wnt/beta-catenin signaling pathway in primary rat osteoblasts.	Fluorides	44-52	catenin beta 1	Rattus norvegicus	146-158
24467380-0	2014	Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer"s disease model via canonical Wnt/beta-catenin pathway.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	143-155
24467380-7	2014	Curcumin nanoparticles increase neuronal differentiation by activating the Wnt/beta-catenin pathway, involved in regulation of neurogenesis.	Curcumin	0-8	catenin beta 1	Rattus norvegicus	79-91
24467380-12	2014	These results suggest that curcumin nanoparticles induce adult neurogenesis through activation of the canonical Wnt/beta-catenin pathway and may offer a therapeutic approach to treating neurodegenerative diseases such as AD, by enhancing a brain self-repair mechanism.	Curcumin	27-35	catenin beta 1	Rattus norvegicus	116-128
24368152-10	2014	In vitro, in cyclic adenosine monophosphate (cAMP)-induced Schwann cells differentiation system, we detected the increased KHSRP in cytoplasm and decreased beta-catenin at protein and mRNA level.	Cyclic AMP	13-43	catenin beta 1	Rattus norvegicus	156-168
24368152-10	2014	In vitro, in cyclic adenosine monophosphate (cAMP)-induced Schwann cells differentiation system, we detected the increased KHSRP in cytoplasm and decreased beta-catenin at protein and mRNA level.	Cyclic AMP	45-49	catenin beta 1	Rattus norvegicus	156-168
24211784-0	2014	Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3beta and beta-catenin pathway.	Dexamethasone	44-57	catenin beta 1	Rattus norvegicus	155-167
24211784-4	2014	We have already reported that Li recovers the inhibitory effects of dexamethasone (DEX), an agonist of glucocorticoid receptor, on the proliferation of adult rat DG-derived neural precursor cells (ADP) via GSK-3beta and beta-catenin pathway.	Dexamethasone	68-81	catenin beta 1	Rattus norvegicus	220-232
24211784-4	2014	We have already reported that Li recovers the inhibitory effects of dexamethasone (DEX), an agonist of glucocorticoid receptor, on the proliferation of adult rat DG-derived neural precursor cells (ADP) via GSK-3beta and beta-catenin pathway.	Dexamethasone	83-86	catenin beta 1	Rattus norvegicus	220-232
24211784-9	2014	In addition, quercetin (Que), a beta-catenin pathway inhibitor, abolished such a recovery effect of VPA.	Quercetin	13-22	catenin beta 1	Rattus norvegicus	32-44
24211784-9	2014	In addition, quercetin (Que), a beta-catenin pathway inhibitor, abolished such a recovery effect of VPA.	Quercetin	24-27	catenin beta 1	Rattus norvegicus	32-44
24211784-12	2014	These suggest that HDAC is not involved in the recovery effect of VPA on ADP proliferation and that VPA recovers the inhibitory effects of DEX via increasing the phosphorylation of Ser(9) on GSK-3beta and following up-regulation of beta-catenin pathway.	Dexamethasone	139-142	catenin beta 1	Rattus norvegicus	232-244
24211784-12	2014	These suggest that HDAC is not involved in the recovery effect of VPA on ADP proliferation and that VPA recovers the inhibitory effects of DEX via increasing the phosphorylation of Ser(9) on GSK-3beta and following up-regulation of beta-catenin pathway.	Serine	181-184	catenin beta 1	Rattus norvegicus	232-244
25247186-6	2014	We found that adult and neonates rats injected with PNV showed immediate neurotoxic manifestations which paralleled with endothelial occludin, beta-catenin, and laminin downregulation indicative of BBBb.	Penicillin V	52-55	catenin beta 1	Rattus norvegicus	143-155
23875703-0	2014	Involvement of the HIF-1alpha and Wnt/beta-catenin pathways in the protective effects of losartan on fatty liver graft with ischaemia/reperfusion injury.	Losartan	89-97	catenin beta 1	Rattus norvegicus	38-50
24802850-0	2014	Astragaloside IV inhibits the up-regulation of Wnt/beta-catenin signaling in rats with unilateral ureteral obstruction.	astragaloside A	0-16	catenin beta 1	Rattus norvegicus	51-63
24802850-1	2014	OBJECTIVE: To investigate the effect of Astragaloside IV (AS-IV) on the regulation of the Wnt/beta-catenin signaling pathway in rats with unilateral ureteral obstruction (UUO).	astragaloside	40-53	catenin beta 1	Rattus norvegicus	94-106
23875703-8	2014	Losartan-induced up-regulation of HIF-1alpha and Wnt/beta-catenin signalling was associated with the recovery of IR-inhibited hepatic Bcl-2, Mn-SOD (manganese superoxide), Cu/Zn-SOD (copper/zinc superoxide) and GSH levels, and the suppression of IR-increased hepatic catalase and caspase 3/caspase 8 levels in MCD/HF-NASH rats.	Copper	183-189	catenin beta 1	Rattus norvegicus	53-65
23481598-10	2014	Doxycycline (50 muM) attenuated hyper-permeability via decreased MMP-2 by protecting VEGFR2, VE-cadherin, Beta-catenin from cleavage and inhibited the reduction of mitochondrial transmembrane potential (MTP), thus prevented mitochondria-mediated apoptotic signaling and capillary rarefaction in the SHR.	Doxycycline	0-11	catenin beta 1	Rattus norvegicus	106-118
23875703-8	2014	Losartan-induced up-regulation of HIF-1alpha and Wnt/beta-catenin signalling was associated with the recovery of IR-inhibited hepatic Bcl-2, Mn-SOD (manganese superoxide), Cu/Zn-SOD (copper/zinc superoxide) and GSH levels, and the suppression of IR-increased hepatic catalase and caspase 3/caspase 8 levels in MCD/HF-NASH rats.	Losartan	0-8	catenin beta 1	Rattus norvegicus	53-65
23875703-8	2014	Losartan-induced up-regulation of HIF-1alpha and Wnt/beta-catenin signalling was associated with the recovery of IR-inhibited hepatic Bcl-2, Mn-SOD (manganese superoxide), Cu/Zn-SOD (copper/zinc superoxide) and GSH levels, and the suppression of IR-increased hepatic catalase and caspase 3/caspase 8 levels in MCD/HF-NASH rats.	Superoxides	159-169	catenin beta 1	Rattus norvegicus	53-65
24272706-7	2014	We further found that ATP up-regulated the Tuj1, Pax6, FZD8 and beta-catenin mRNA levels of MSCs, which could be reversed by application of TNP-ATP.	Adenosine Triphosphate	22-25	catenin beta 1	Rattus norvegicus	64-76
23875703-8	2014	Losartan-induced up-regulation of HIF-1alpha and Wnt/beta-catenin signalling was associated with the recovery of IR-inhibited hepatic Bcl-2, Mn-SOD (manganese superoxide), Cu/Zn-SOD (copper/zinc superoxide) and GSH levels, and the suppression of IR-increased hepatic catalase and caspase 3/caspase 8 levels in MCD/HF-NASH rats.	Glutathione	211-214	catenin beta 1	Rattus norvegicus	53-65
23875703-9	2014	In conclusion, up-regulation of the HIF-1alpha and Wnt/beta-catenin signalling pathways are part of the mechanism of the positive effects of losartan-related AngII inhibition in MCD/HF-NASH rats with liver IRI.	Losartan	141-149	catenin beta 1	Rattus norvegicus	55-67
24272706-7	2014	We further found that ATP up-regulated the Tuj1, Pax6, FZD8 and beta-catenin mRNA levels of MSCs, which could be reversed by application of TNP-ATP.	Adenosine Triphosphate	144-147	catenin beta 1	Rattus norvegicus	64-76
24272706-8	2014	Together these in vitro data provided convergent evidence that ATP from light-depolarized-astrocytes activated the wnt/beta-catenin signaling of MSCs through binding to the P2X receptors, and promoted the neuronal differentiation of MSCs.	Adenosine Triphosphate	63-66	catenin beta 1	Rattus norvegicus	119-131
23512909-7	2014	siRNA treatment in rat hepatoma cells confirmed that silencing of beta-catenin exacerbated fatty acid-induced fat accumulation, which implicated an important function of Wnt/beta-catenin signaling in hepatic fat metabolism.	Fatty Acids	91-101	catenin beta 1	Rattus norvegicus	66-78
23512909-7	2014	siRNA treatment in rat hepatoma cells confirmed that silencing of beta-catenin exacerbated fatty acid-induced fat accumulation, which implicated an important function of Wnt/beta-catenin signaling in hepatic fat metabolism.	Fatty Acids	91-101	catenin beta 1	Rattus norvegicus	174-186
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	catenin beta 1	Rattus norvegicus	222-234
24617038-0	2013	Inhibition of beta-catenin and KRAS expressions by Piper betle in azoxymethane-induced colon cancer of male Fischer 344 rats.	Azoxymethane	66-78	catenin beta 1	Rattus norvegicus	14-26
24080207-6	2013	Tumors exposed to raloxifene, bexarotene and/or the combination showed significant suppression of proliferating cell nuclear antigen, cyclin D1, and beta-catenin with an increased apoptotic cells (3-fold) and p21 expression (3.8-fold) as compared tumors of rats fed control diet.	Raloxifene Hydrochloride	18-28	catenin beta 1	Rattus norvegicus	149-161
24080207-6	2013	Tumors exposed to raloxifene, bexarotene and/or the combination showed significant suppression of proliferating cell nuclear antigen, cyclin D1, and beta-catenin with an increased apoptotic cells (3-fold) and p21 expression (3.8-fold) as compared tumors of rats fed control diet.	Bexarotene	30-40	catenin beta 1	Rattus norvegicus	149-161
23996200-1	2013	Dexamethasone (Dex) regulates osteoblastic and adipocytic differentiation in mesenchymal progenitor cells through regulation of Wnt/beta-catenin signaling.	Dexamethasone	0-13	catenin beta 1	Rattus norvegicus	132-144
23996200-1	2013	Dexamethasone (Dex) regulates osteoblastic and adipocytic differentiation in mesenchymal progenitor cells through regulation of Wnt/beta-catenin signaling.	Dexamethasone	0-3	catenin beta 1	Rattus norvegicus	132-144
23619963-9	2013	Serotonin significantly increased the cytoplasmatic beta-catenin protein levels by the inhibition of the enzyme glycogen synthase kinase-3beta, that by phosphorylating beta-catenin promotes its degradation.	Serotonin	0-9	catenin beta 1	Rattus norvegicus	52-64
23619963-9	2013	Serotonin significantly increased the cytoplasmatic beta-catenin protein levels by the inhibition of the enzyme glycogen synthase kinase-3beta, that by phosphorylating beta-catenin promotes its degradation.	Serotonin	0-9	catenin beta 1	Rattus norvegicus	168-180
23619963-11	2013	We suggest that serotonin might stimulate canonical Wnt/beta-catenin-dependent bone formation to occur.	Serotonin	16-25	catenin beta 1	Rattus norvegicus	56-68
23921644-6	2013	The effects of WIF1 on beta-catenin pathway could be reversed by LiCl regarding signaling pathways and effector and respondent molecules in H9c2 cells, consistent with the expression levels of c-myc, natriuretic peptide precursor type B and skeletal muscle actin alpha1.	Lithium Chloride	65-69	catenin beta 1	Rattus norvegicus	23-35
24129747-2	2013	polysaccharides upregulate Wnt/beta-catenin signaling in chondrocytes.	Polysaccharides	0-15	catenin beta 1	Rattus norvegicus	31-43
24129747-10	2013	In the present study, the effects of BCBPs on Wnt/beta-catenin signaling in chondrocytes were investigated.	bcbps	37-42	catenin beta 1	Rattus norvegicus	50-62
24129747-17	2013	Furthermore, compared with the control group, the mRNA and protein expression of Wnt-4, beta-catenin, Frizzled-2 and cyclin D1 in the BCBP-treated groups markedly increased, whereas the mRNA and protein expression of GSK-3beta significantly decreased.	BCBP	134-138	catenin beta 1	Rattus norvegicus	88-100
24078029-0	2013	Simultaneous disruption of estrogen receptor and Wnt/beta-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats.	methyl amooranin	91-107	catenin beta 1	Rattus norvegicus	53-65
24145616-0	2013	Lysophosphatidic acid activates beta-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells.	lysophosphatidic acid	0-21	catenin beta 1	Rattus norvegicus	32-44
24145616-7	2013	The activation of beta-catenin/TCF signaling was blocked by pertussis toxin (PTX) and a protein kinase C (PKC) inhibitor.	tcf	31-34	catenin beta 1	Rattus norvegicus	18-30
24145616-9	2013	These results showed that LPA activates beta-catenin/TCF signaling in a PTX- and PKC-dependent manner, which contributes to LPA-induced cell survival in the HPCs.	lysophosphatidic acid	26-29	catenin beta 1	Rattus norvegicus	40-52
24060489-6	2013	Two previously reported beta-catenin/TCF antagonists (calphostin C, xanthothricin) and XAV939 (tankyrase antagonist) inhibited Wnt-activated genes in a dose-dependent fashion.	toxoflavin	68-81	catenin beta 1	Rattus norvegicus	24-36
24251870-6	2013	EGCg also attenuated H2O2-mediated cell cycle arrest at the G1-S phase through the glycogen synthase kinase-3beta (GSK-3beta)/beta-catenin/cyclin D1 signalling pathway.	epigallocatechin gallate	0-4	catenin beta 1	Rattus norvegicus	126-138
24251870-6	2013	EGCg also attenuated H2O2-mediated cell cycle arrest at the G1-S phase through the glycogen synthase kinase-3beta (GSK-3beta)/beta-catenin/cyclin D1 signalling pathway.	Hydrogen Peroxide	21-25	catenin beta 1	Rattus norvegicus	126-138
24260215-11	2013	Collectively, our findings indicate that miR-200a may function as an important regulatory factor in neoplastic transition of HOCs by targeting the beta-catenin pathway.	hocs	125-129	catenin beta 1	Rattus norvegicus	147-159
24060489-0	2013	Investigation of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription.	3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-diones	17-65	catenin beta 1	Rattus norvegicus	99-111
24060489-9	2013	The data indicate the compounds act at the level of beta-catenin to inhibit Wnt/beta-catenin/TCF function and highlight a robust strategy for assessing the activity of beta-catenin/TCF antagonists.	tcf	93-96	catenin beta 1	Rattus norvegicus	52-64
24060489-4	2013	We used xanthothricin, a known beta-catenin/TCF antagonist of microbial origin, as a lead compound to synthesize related analogues with drug-like features such as low molecular weight and good metabolic stability.	toxoflavin	8-21	catenin beta 1	Rattus norvegicus	31-43
24060489-6	2013	Two previously reported beta-catenin/TCF antagonists (calphostin C, xanthothricin) and XAV939 (tankyrase antagonist) inhibited Wnt-activated genes in a dose-dependent fashion.	tcf	37-40	catenin beta 1	Rattus norvegicus	24-36
24223741-10	2013	Compared with the casein group, the BCAA group had lower levels of alpha-smooth muscle actin, vascular endothelial growth factor, p-beta-catenin, p-p38 mitogen-activated protein kinase, proliferating cell nuclear antigen, and caspase-3 protein expression, as well as a higher level of cleaved caspase-3 protein expression.	Amino Acids, Branched-Chain	36-40	catenin beta 1	Rattus norvegicus	132-144
24060489-6	2013	Two previously reported beta-catenin/TCF antagonists (calphostin C, xanthothricin) and XAV939 (tankyrase antagonist) inhibited Wnt-activated genes in a dose-dependent fashion.	calphostin C	54-66	catenin beta 1	Rattus norvegicus	24-36
23351165-1	2013	OBJECTIVE: Lithium is an activator of beta-catenin signaling and beta-catenin plays an important role in regulating bone formation and remodeling.	Lithium	11-18	catenin beta 1	Rattus norvegicus	38-50
23816368-0	2013	The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture.	Curcumin	16-24	catenin beta 1	Rattus norvegicus	74-86
23816368-3	2013	The present study was undertaken to investigate the mechanisms involved in neuroprotective effects of curcumin, particularly involving Wnt/beta-catenin and PI3K pathways.	Curcumin	102-110	catenin beta 1	Rattus norvegicus	139-151
23816368-8	2013	The phosphorylation of beta-catenin was avoided and the levels of free beta-catenin were increased by curcumin to promote cell survival upon treatment with Abeta.	Curcumin	102-110	catenin beta 1	Rattus norvegicus	71-83
23816368-11	2013	DISCUSSION: These results reinforce the neuroprotective effects of curcumin on Abeta toxicity and add some evidence that its mechanism may involve beta-catenin and PI3K signaling pathway in organotypic hippocampal slice culture.	Curcumin	67-75	catenin beta 1	Rattus norvegicus	147-159
23806715-6	2013	TNF-alpha dose-dependently increased soluble beta-catenin and phosphorylated GSK-3beta levels, which was blocked by SPD304 and PD169316.	SPD-304	116-122	catenin beta 1	Rattus norvegicus	45-57
23806715-6	2013	TNF-alpha dose-dependently increased soluble beta-catenin and phosphorylated GSK-3beta levels, which was blocked by SPD304 and PD169316.	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	127-135	catenin beta 1	Rattus norvegicus	45-57
24048193-2	2013	The objective of this study was to evaluate the potential involvement of HIF-1alpha in TGF-beta1/beta-Catenin and Snail pathway after PQ poisoning.	Paraquat	134-136	catenin beta 1	Rattus norvegicus	97-109
24048193-12	2013	Meanwhile, immunofluorescent analysis of HIF-1alpha revealed partial staining appearing from 2 h. Our data illustrated a positive correlation between Snail, beta-catenin signaling and HIF-1alpha, suggesting a potential synergistic role of HIF-1alpha in PQ-induced pulmonary fibrosis, which may be independent of GSK-3beta.	Paraquat	253-255	catenin beta 1	Rattus norvegicus	157-169
24273979-8	2013	Compared with the Ang II group, mRNA and protein expressions of Wnt4, Dvl-1, beta-catenin, CyclinD1, Col I, and Col III were obviously down-regulated in the middle dose TMP plus Ang II group and the high dose TMP plus Ang II group (P &lt; 0.05).	tetramethylpyrazine	169-172	catenin beta 1	Rattus norvegicus	77-89
24273979-8	2013	Compared with the Ang II group, mRNA and protein expressions of Wnt4, Dvl-1, beta-catenin, CyclinD1, Col I, and Col III were obviously down-regulated in the middle dose TMP plus Ang II group and the high dose TMP plus Ang II group (P &lt; 0.05).	tetramethylpyrazine	209-212	catenin beta 1	Rattus norvegicus	77-89
23619006-6	2013	Immunofluorescent labeling indicated that beta-catenin was localized mainly in the neurons; co-localization of beta-catenin and active caspase-3 was found following TCDD exposure.	Polychlorinated Dibenzodioxins	165-169	catenin beta 1	Rattus norvegicus	111-123
23735664-9	2013	These results suggested that Zn prevented the diabetes-induced increase in osteoclastogenesis and decrease in osteoblastogenesis by inhibiting RANK expression and stimulating IGF-1/IGF-1R/Akt/GSK3beta/beta-catenin signaling, respectively.	Zinc	29-31	catenin beta 1	Rattus norvegicus	201-213
23685950-6	2013	Moreover, treatment of the cells with glutamate (1 mmol/L) caused significant overactivation of GSK-3beta and prevented beta-catenin translocation to the nucleus.	Glutamic Acid	38-47	catenin beta 1	Rattus norvegicus	120-132
23685950-7	2013	Pretreatment with carbachol (0.01 mumol/L) blocked glutamate-induced cell death and GSK-3beta overactivation, and markedly enhanced beta-catenin transcriptional activity.	Carbachol	18-27	catenin beta 1	Rattus norvegicus	132-144
23619006-0	2013	2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/beta-catenin signaling pathway.	Polychlorinated Dibenzodioxins	0-12	catenin beta 1	Rattus norvegicus	140-152
23619006-7	2013	Further, TCDD exposure decreased the level of pSer9-GSK-3beta and beta-catenin, and increased apoptosis in the PC12 neuronal cell line in a dose-dependent manner.	Polychlorinated Dibenzodioxins	9-13	catenin beta 1	Rattus norvegicus	66-78
23619006-4	2013	Western blot and immunohistochemical experiments revealed a significant down-regulation of beta-catenin and phospho-glycogen synthase kinase-3beta (pSer9-GSK-3beta) after TCDD exposure.	Polychlorinated Dibenzodioxins	171-175	catenin beta 1	Rattus norvegicus	91-103
23619006-8	2013	Interestingly the application of lithium chloride, a GSK-3beta inhibitor, reversed the suppressive effect of TCDD on beta-catenin in PC12 cells and primary cortical neurons restoring cell viability and protecting cells from apoptosis as compared to untreated controls.	Lithium Chloride	33-49	catenin beta 1	Rattus norvegicus	117-129
23619006-8	2013	Interestingly the application of lithium chloride, a GSK-3beta inhibitor, reversed the suppressive effect of TCDD on beta-catenin in PC12 cells and primary cortical neurons restoring cell viability and protecting cells from apoptosis as compared to untreated controls.	Polychlorinated Dibenzodioxins	109-113	catenin beta 1	Rattus norvegicus	117-129
23619006-9	2013	Taken together, these results indicate that the canonical Wnt/beta-catenin signaling pathway may play an important role in TCDD-induced neurotoxicity and neuronal apoptosis.	Polychlorinated Dibenzodioxins	123-127	catenin beta 1	Rattus norvegicus	62-74
23908081-4	2013	RESULTS: After CJTF treatment, the rat arthritis score and paw edema score in RA model rats were significantly decreased when the RA model rats were treated with CJTF, the SFRP4 expression was significantly up-regulated, while the beta-catenin and C-myc gene expression were significantly downregulated in RA model rat synovial tissues.	cjtf	15-19	catenin beta 1	Rattus norvegicus	231-243
23908081-4	2013	RESULTS: After CJTF treatment, the rat arthritis score and paw edema score in RA model rats were significantly decreased when the RA model rats were treated with CJTF, the SFRP4 expression was significantly up-regulated, while the beta-catenin and C-myc gene expression were significantly downregulated in RA model rat synovial tissues.	cjtf	162-166	catenin beta 1	Rattus norvegicus	231-243
23178162-9	2013	As a whole, this study supports the "critical period hypothesis" and further suggests that perimenopausal estradiol replacement may prevent neurodegenerative changes in the hippocampus by maintaining favorable Wnt/beta-Catenin signaling.	Estradiol	106-115	catenin beta 1	Rattus norvegicus	214-226
23571712-4	2013	An in vitro investigation revealed that GLP-1(28-36)amide stimulates beta-catenin (beta-cat) Ser(675) phosphorylation in both the clonal INS-1 cell line and rat primary pancreatic islet cells.	Amides	52-57	catenin beta 1	Rattus norvegicus	69-81
23571712-4	2013	An in vitro investigation revealed that GLP-1(28-36)amide stimulates beta-catenin (beta-cat) Ser(675) phosphorylation in both the clonal INS-1 cell line and rat primary pancreatic islet cells.	Amides	52-57	catenin beta 1	Rattus norvegicus	69-77
23571712-4	2013	An in vitro investigation revealed that GLP-1(28-36)amide stimulates beta-catenin (beta-cat) Ser(675) phosphorylation in both the clonal INS-1 cell line and rat primary pancreatic islet cells.	Serine	93-96	catenin beta 1	Rattus norvegicus	69-81
23571712-4	2013	An in vitro investigation revealed that GLP-1(28-36)amide stimulates beta-catenin (beta-cat) Ser(675) phosphorylation in both the clonal INS-1 cell line and rat primary pancreatic islet cells.	Serine	93-96	catenin beta 1	Rattus norvegicus	69-77
23571712-8	2013	Finally, PKA inhibition attenuated the effect of GLP-1(28-36)amide on beta-cat Ser(675) phosphorylation and cyclin D1 expression in the INS-1 cell line.	Amides	61-66	catenin beta 1	Rattus norvegicus	70-78
23571712-8	2013	Finally, PKA inhibition attenuated the effect of GLP-1(28-36)amide on beta-cat Ser(675) phosphorylation and cyclin D1 expression in the INS-1 cell line.	Serine	79-82	catenin beta 1	Rattus norvegicus	70-78
23571712-10	2013	Our observations suggest that GLP-1(28-36)amide may exert its effect through the PKA/beta-catenin signaling pathway.	Amides	42-47	catenin beta 1	Rattus norvegicus	85-97
23826409-1	2013	AIMS: Activation of specific signaling pathways in response to mechanical trauma causes delayed neuronal apoptosis; GSK-3beta/beta-catenin signaling plays a critical role in the apoptosis of neurons in CNS diseases, SGK was discovered as a regulator of GSK-3beta/beta-catenin pathway, The goal of this study was to determine if the mechanism of cell death or survival mediated by the SGK/GSK-3beta/beta-catenin pathway is involved in a rat model of TBI.	Thioacetazone	449-452	catenin beta 1	Rattus norvegicus	126-138
23198873-10	2013	Finally, reducing beta-catenin levels with either siRNA or pyrvinium impaired glucose- and KCl-stimulated insulin secretion.	pyrvinium	59-68	catenin beta 1	Rattus norvegicus	18-30
23937038-14	2013	These findings demonstrate that osthole may inhibit the proliferation of osteoblast by regulating the Wnt/beta-catenin signaling in osteoblast.	osthol	32-39	catenin beta 1	Rattus norvegicus	106-118
23066786-8	2013	In streptozotocin-induced diabetic rats, retinal levels of 3-NT, beta-catenin, nuclear beta-catenin, pLRP6, VEGF, and ICAM-1 were markedly increased.	Streptozocin	3-17	catenin beta 1	Rattus norvegicus	65-77
23066786-8	2013	In streptozotocin-induced diabetic rats, retinal levels of 3-NT, beta-catenin, nuclear beta-catenin, pLRP6, VEGF, and ICAM-1 were markedly increased.	Streptozocin	3-17	catenin beta 1	Rattus norvegicus	87-99
23426897-0	2013	Lithium induces follicular atresia in rat ovary through a GSK-3beta/beta-catenin dependent mechanism.	Lithium	0-7	catenin beta 1	Rattus norvegicus	68-80
23426897-8	2013	At the molecular level, lithium increased the level of phosphorylated glycogen synthase kinase-3beta, and unexpectedly decreased the expression of active (stabilized) beta-catenin.	Lithium	24-31	catenin beta 1	Rattus norvegicus	167-179
23426897-9	2013	Altogether, our results indicate that lithium disrupts the balance between proliferation and apoptosis in granulosa cells, leading to follicular atresia possibly through the reduction in both the stabilized beta-catenin and 17beta-estradiol synthesis.	Lithium	38-45	catenin beta 1	Rattus norvegicus	207-219
23080431-0	2013	Effects of cadmium on the sub-cellular localization of beta-catenin and beta-catenin-regulated gene expression in NRK-52E cells.	Cadmium	11-18	catenin beta 1	Rattus norvegicus	55-67
23080431-0	2013	Effects of cadmium on the sub-cellular localization of beta-catenin and beta-catenin-regulated gene expression in NRK-52E cells.	Cadmium	11-18	catenin beta 1	Rattus norvegicus	72-84
23080431-4	2013	In this study, we examined the effects of Cd on the subcellular localization of beta-catenin, the cadherin/beta-catenin complex and beta-catenin-mediated gene transcription in rat proximal tubule NRK-52E cells.	Cadmium	42-44	catenin beta 1	Rattus norvegicus	80-92
23080431-7	2013	The expression of the beta-catenin-sensitive gene, c-jun was significantly increased in cells exposed to 5 muM Cd.	Cadmium	111-113	catenin beta 1	Rattus norvegicus	22-34
23080431-9	2013	Additional studies utilizing the TOPFLASH beta-catenin reporter gene construct showed that Cd caused a 2-3 fold increase in the expression of the luciferase reporter gene.	Cadmium	91-93	catenin beta 1	Rattus norvegicus	42-54
23080431-10	2013	Overall, these results indicate that Cd disrupts the cadherin/beta-catenin complex in NRK-52E cells, but this effect leads to only partial activation of beta-catenin-mediated gene transcription.	Cadmium	37-39	catenin beta 1	Rattus norvegicus	62-74
23937038-11	2013	The result of Western Blot showed that osthole reduced the expression of PCNA and beta-catenin protein in a dose-dependent manner.	osthol	39-46	catenin beta 1	Rattus norvegicus	82-94
23198873-0	2013	Identification of a pathway by which glucose regulates beta-catenin signalling via the cAMP/protein kinase A pathway in beta-cell models.	Glucose	37-44	catenin beta 1	Rattus norvegicus	55-67
23198873-3	2013	In the present study we show that beta-catenin levels and downstream signalling are regulated by changes in glucose levels in INS-1E and beta-TC6-F7 beta-cell models.	Glucose	108-115	catenin beta 1	Rattus norvegicus	34-46
23198873-4	2013	We found a glucose-dependent increase in levels of beta-catenin in the cytoplasm and nucleus of INS-1E cells.	Glucose	11-18	catenin beta 1	Rattus norvegicus	51-63
23198873-9	2013	Two different inhibitors of adenylate cyclase and PKA signalling blocked the effects of glucose, whereas siRNA (small interfering RNA) knockdown of PKA blocked the effects of glucose on beta-catenin signalling.	Glucose	175-182	catenin beta 1	Rattus norvegicus	186-198
23149278-5	2013	Treatment of the injured rats with the beta-catenin inhibitor ICG-001 (oral gavage at 200mg/kg/day for 8days, commenced at day 2 post injury) enhanced COL2A1 gene expression (by qRT-PCR) and increased proportion of cartilage tissue (by histological analysis), but decreased level of osterix expression and amount of bone tissue, at the injury site by day 10 post-injury (n=8, P&lt;0.01 compared to vehicle controls).	Indocyanine Green	62-65	catenin beta 1	Rattus norvegicus	39-51
23198873-10	2013	Finally, reducing beta-catenin levels with either siRNA or pyrvinium impaired glucose- and KCl-stimulated insulin secretion.	Glucose	78-85	catenin beta 1	Rattus norvegicus	18-30
23149278-6	2013	Consistently, in vitro studies with bone marrow stromal cells from normal rats showed that beta-catenin inhibitor ICG-001 dose dependently inhibited expression of Wnt target genes Cyclin D1 and survivin (P&lt;0.01).	Indocyanine Green	114-117	catenin beta 1	Rattus norvegicus	91-103
23198873-10	2013	Finally, reducing beta-catenin levels with either siRNA or pyrvinium impaired glucose- and KCl-stimulated insulin secretion.	Potassium Chloride	91-94	catenin beta 1	Rattus norvegicus	18-30
23198873-11	2013	Taken together the results of the present study define a pathway by which changes in glucose levels can regulate beta-catenin using a mechanism which involves cAMP production and the activation of PKA.	Glucose	85-92	catenin beta 1	Rattus norvegicus	113-125
23198873-11	2013	Taken together the results of the present study define a pathway by which changes in glucose levels can regulate beta-catenin using a mechanism which involves cAMP production and the activation of PKA.	Cyclic AMP	159-163	catenin beta 1	Rattus norvegicus	113-125
22402320-6	2013	Dexamethasone effectively mediated rMAPC osteogenic differentiation by inducing the formation of a mineralized collagen type I network, and facilitated the activation of the wnt/beta-catenin, a crucial pathway in skeletal development.	Dexamethasone	0-13	catenin beta 1	Rattus norvegicus	178-190
23117658-1	2013	OBJECTIVE: In vitro, transglutaminase-2 (TG2)-mediated activation of the beta-catenin signaling pathway is central in warfarin-induced calcification, warranting inquiry into the importance of this signaling axis as a target for preventive therapy of vascular calcification in vivo.	Warfarin	118-126	catenin beta 1	Rattus norvegicus	73-85
23291777-11	2013	Immunofluoresence staining and western blot analysis demonstrated that both ibuprofen and p-ibuprofen suppressed beta-catenin nuclear translocation in colon cancer cells.	Ibuprofen	76-85	catenin beta 1	Rattus norvegicus	113-125
23291777-11	2013	Immunofluoresence staining and western blot analysis demonstrated that both ibuprofen and p-ibuprofen suppressed beta-catenin nuclear translocation in colon cancer cells.	p-ibuprofen	90-101	catenin beta 1	Rattus norvegicus	113-125
23160799-8	2013	We found that the appropriate concentrations and time-points of CsA-induced the expression of Dvl-1 and subsequent up-regulation of beta-catenin and c-Myc, which is consistent with previously demonstrated concentrations and time-points when H9c2 cells apoptosis occurred.	Cyclosporine	64-67	catenin beta 1	Rattus norvegicus	132-144
23160799-12	2013	Moreover, we further deleted the downstream member beta-catenin by specific siRNA, and found that CsA-induced the Bax/Bcl-2 ratio and the expression of c-Myc, which were attenuated.	Cyclosporine	98-101	catenin beta 1	Rattus norvegicus	51-63
22716201-0	2013	Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/beta-catenin signalling and reduces colon pre-neoplasia in rats.	Genistein	0-9	catenin beta 1	Rattus norvegicus	81-93
22716201-0	2013	Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/beta-catenin signalling and reduces colon pre-neoplasia in rats.	Azoxymethane	39-51	catenin beta 1	Rattus norvegicus	81-93
22716201-7	2013	AOM injection induced aberrant nuclear accumulation of beta-catenin in the CTL group but not in the SPI or GEN group.	Azoxymethane	0-3	catenin beta 1	Rattus norvegicus	55-67
22716201-13	2013	By testing WNT/beta-catenin signalling as a biomarker of colon carcinogenic potential, we showed the novel role of GEN as a suppressor of carcinogen-induced WNT/beta-catenin signalling in preventing the development of early colon neoplasia.	Genistein	115-118	catenin beta 1	Rattus norvegicus	15-27
22716201-13	2013	By testing WNT/beta-catenin signalling as a biomarker of colon carcinogenic potential, we showed the novel role of GEN as a suppressor of carcinogen-induced WNT/beta-catenin signalling in preventing the development of early colon neoplasia.	Genistein	115-118	catenin beta 1	Rattus norvegicus	161-173
23117658-2	2013	METHODS AND RESULTS: The adverse effects of warfarin-induced elastocalcinosis in a rat model include calcification of the aortic media, loss of the cellular component in the vessel wall, and isolated systolic hypertension, associated with accumulation and activation of TG2 and activation of beta-catenin signaling.	Warfarin	44-52	catenin beta 1	Rattus norvegicus	292-304
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	Warfarin	17-25	catenin beta 1	Rattus norvegicus	202-214
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	KCC 009	117-124	catenin beta 1	Rattus norvegicus	202-214
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	Flavonoids	161-173	catenin beta 1	Rattus norvegicus	202-214
23117658-3	2013	These effects of warfarin can be completely reversed by intraperitoneal administration of the TG2-specific inhibitor KCC-009 or dietary supplementation with the bioflavonoid quercetin, known to inhibit beta-catenin signaling.	Quercetin	174-183	catenin beta 1	Rattus norvegicus	202-214
23117658-7	2013	CONCLUSIONS: Inhibition of the TG2/beta-catenin signaling axis seems to prevent warfarin-induced elastocalcinosis and to control isolated systolic hypertension.	Warfarin	80-88	catenin beta 1	Rattus norvegicus	35-47
22891217-4	2012	In addition, Mab2F1 also attenuated the accumulation of beta-catenin and overexpression of vascular endothelial growth factor, intercellular adhesion molecule-1, and tumor necrosis factor-alpha induced by high-glucose medium in retinal endothelial cells.	Glucose	210-217	catenin beta 1	Rattus norvegicus	56-68
23449329-6	2013	Yeast two-hybrid interaction assays revealed that DHT promoted recruitment of numerous cofactors to AR such as TIF2, SRC1, beta-catenin, NCoA3, gelsolin and PROX1 in a dose-dependent manner.	Dihydrotestosterone	50-53	catenin beta 1	Rattus norvegicus	123-135
24260743-0	2013	Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/beta-catenin and COX-2 pathways.	Phytic Acid	11-33	catenin beta 1	Rattus norvegicus	113-125
24260743-10	2013	Interestingly, the administration of IP6 had also markedly decreased beta-catenin and COX-2 in colon tumors.	Phytic Acid	37-40	catenin beta 1	Rattus norvegicus	69-81
24260743-11	2013	Thus, the downregulation of beta-catenin and COX-2 could play a role in inhibiting the CRC development induced by IP6 and thereby act as a potent anticancer agent.	Phytic Acid	114-117	catenin beta 1	Rattus norvegicus	28-40
23691520-0	2013	The Effect of Dantonic Pill on beta -Catenin Expression in a Rat Model of Streptozotocin-Induced Early Stage of Diabetic Nephropathy.	Streptozocin	74-88	catenin beta 1	Rattus norvegicus	31-44
23691520-2	2013	This study was performed to determine the effect of Dantonic Pill (DP) treatment on beta -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control.	Streptozocin	127-141	catenin beta 1	Rattus norvegicus	84-97
23691520-2	2013	This study was performed to determine the effect of Dantonic Pill (DP) treatment on beta -catenin expression in a rat model of streptozotocin- (STZ-) induced early-stage DN, with irbesartan treatment as a positive control.	Streptozocin	144-147	catenin beta 1	Rattus norvegicus	84-97
23691520-4	2013	After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of beta -catenin was not downregulated in the renal cortex.	dp	24-26	catenin beta 1	Rattus norvegicus	181-194
23691520-4	2013	After the treatments of DP and irbesartan, the albuminuria level, kidney weight/body weight, and thickness of the glomerular basement membrane were decreased, but the expression of beta -catenin was not downregulated in the renal cortex.	Irbesartan	31-41	catenin beta 1	Rattus norvegicus	181-194
22270399-9	2012	Immunofluorescence demonstrated that cells within the glomeruli restored beta-catenin expression after BIO and SB216763 treatment in cells within diabetic glomeruli colocalized with fragmented nuclei by 4",6-diamidino-2-phenylindole staining.	SB 216763	111-119	catenin beta 1	Rattus norvegicus	73-85
22270399-9	2012	Immunofluorescence demonstrated that cells within the glomeruli restored beta-catenin expression after BIO and SB216763 treatment in cells within diabetic glomeruli colocalized with fragmented nuclei by 4",6-diamidino-2-phenylindole staining.	6-diamidino-2-phenylindole	206-232	catenin beta 1	Rattus norvegicus	73-85
23803085-0	2013	Suppression of beta-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).	Azoxymethane	86-98	catenin beta 1	Rattus norvegicus	15-27
23803085-0	2013	Suppression of beta-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).	Phytic Acid	143-154	catenin beta 1	Rattus norvegicus	15-27
23803085-0	2013	Suppression of beta-catenin and cyclooxygenase-2 expression and cell proliferation in azoxymethane-induced colonic cancer in rats by rice bran phytic acid (PA).	Phytic Acid	156-158	catenin beta 1	Rattus norvegicus	15-27
23606879-8	2013	PE dose dependently reduced hepatic beta -catenin and augmented glycogen synthase kinase-3 beta expression.	pe	0-2	catenin beta 1	Rattus norvegicus	36-49
22776263-8	2013	RESULTS: Two injections of SB-415286 led to an elevation of beta-catenin expression and an increase in the number of proliferating osteoblasts in expanding sutures on day 2 and day 4.	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	27-36	catenin beta 1	Rattus norvegicus	60-72
23238999-0	2012	Epimedium-derived flavonoids modulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats via Wnt/beta-catenin signal pathway activation.	Flavonoids	18-28	catenin beta 1	Rattus norvegicus	176-188
23238999-1	2012	OBJECTIVE: To observe the function of wnt/beta-catenin signal pathway on the process that epimedium-derived flavonoids (EFs) regulate the balance between osteogenic differentiation and adipogenic differentiation in bone marrow stromal cells of ovariectomized rats, and to provide an experimental evidence for the mechanism of EFs on treating postmenopausal osteoporosis.	Flavonoids	108-118	catenin beta 1	Rattus norvegicus	42-54
23157480-13	2012	The results of these experiments validated four genes as authentic and direct targets of beta-catenin: Gabra3 for the receptor of GABA neurotransmitter, Calb2 for the Ca(2+)-binding protein calretinin, and the Cacna1g and Kcna6 genes for voltage-gated ion channels.	gamma-Aminobutyric Acid	130-134	catenin beta 1	Rattus norvegicus	89-101
22270399-0	2012	Sustained Wnt/beta-catenin signaling rescues high glucose induction of transforming growth factor-beta1-mediated renal fibrosis.	Glucose	50-57	catenin beta 1	Rattus norvegicus	14-26
22270399-2	2012	METHODS: This study found that sustained Wnt/beta-catenin signaling was required to protect glomerular mesangial cells from high glucose induction of TGF-beta1-mediated fibrosis using in vitro and in vivo diabetic models.	Glucose	129-136	catenin beta 1	Rattus norvegicus	45-57
22270399-4	2012	Restoring Wnt4, Wnt5a and cytosolic beta-catenin levels by transfecting Wnt4, Wnt5a and stable beta-catenin alleviated the stimulatory effect of high glucose on c-Jun mediated TGF-beta1 fibrosis.	Glucose	150-157	catenin beta 1	Rattus norvegicus	36-48
22270399-4	2012	Restoring Wnt4, Wnt5a and cytosolic beta-catenin levels by transfecting Wnt4, Wnt5a and stable beta-catenin alleviated the stimulatory effect of high glucose on c-Jun mediated TGF-beta1 fibrosis.	Glucose	150-157	catenin beta 1	Rattus norvegicus	95-107
23302485-16	2012	However, the expression of beta-catenin and cyclin D1 was significantly increased with the concentration of SB-216763 increasing.	SB 216763	108-117	catenin beta 1	Rattus norvegicus	27-39
22841957-0	2012	Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3beta/beta-catenin pathway.	Valproic Acid	21-34	catenin beta 1	Rattus norvegicus	155-167
22902902-4	2012	In the meanwhile, inhibition of the canonical Wnt signaling pathway, including the activation of glycogen synthase kinase-3beta (GSK-3beta) and decrease of beta-catenin, was also found in 6-OHDA-lesioned rats.	Oxidopamine	188-194	catenin beta 1	Rattus norvegicus	156-168
22981403-10	2012	The same dose of sulindac upregulated the expression of Dvl, beta-catenin, Bcl2 and claudin-5, and downregulated APC, P-beta-catenin and Bax compared with Vehicle group.	Sulindac	17-25	catenin beta 1	Rattus norvegicus	61-73
22981403-10	2012	The same dose of sulindac upregulated the expression of Dvl, beta-catenin, Bcl2 and claudin-5, and downregulated APC, P-beta-catenin and Bax compared with Vehicle group.	Sulindac	17-25	catenin beta 1	Rattus norvegicus	120-132
22981403-11	2012	CONCLUSIONS: These results showed that sulindac had a significant beneficial effect in cerebral ischemia; this effect may be correlated with the activation of the Wnt/beta-catenin signaling.	Sulindac	39-47	catenin beta 1	Rattus norvegicus	167-179
22922600-7	2012	We found that amphetamine increased Wnt3 protein expression, increased pLRP6 (threonine-1572) levels, increased beta-catenin levels, increased GSK-3beta phosphorylation at serine-9, consistent with inhibition of GSK-3beta activity, and diminished GSK-3beta phosphorylation at tyrosine-216.	Amphetamine	14-25	catenin beta 1	Rattus norvegicus	112-124
22981403-0	2012	Beneficial effects of sulindac in focal cerebral ischemia: a positive role in Wnt/beta-catenin pathway.	Sulindac	22-30	catenin beta 1	Rattus norvegicus	82-94
22884810-0	2012	Selective G2/M arrest in a p53(Val135)-transformed cell line induced by lithium is mediated through an intricate network of MAPK and beta-catenin signaling pathways.	Lithium	72-79	catenin beta 1	Rattus norvegicus	133-145
23158493-0	2012	[Involvement of Wnt/beta-catenin signaling in the osteogenesis of bone marrow mesenchymal stem cells induced by drynaria total flavonoids].	Flavonoids	127-137	catenin beta 1	Rattus norvegicus	20-32
23158493-1	2012	OBJECTIVE: To explore the effects of the expression of Wnt/beta-catenin signaling factor mRNA during drynaria total flavonoids on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).	Flavonoids	116-126	catenin beta 1	Rattus norvegicus	59-71
23158493-8	2012	At Day 14, the expression of beta-catenin mRNA was higher in the drynaria total flavonoids group higher than that in the blank control group (0.357 +- 0.063 vs 0.174 +- 0.013, P &lt; 0.05).	Flavonoids	80-90	catenin beta 1	Rattus norvegicus	29-41
22875341-9	2012	The present study indicates that prenatal and early postnatal exposure to a high-saturated-fat diet suppresses the development of skeletal muscle and myogenic genes via Wnt/beta-catenin signaling, and the inappropriate muscle development could potentially contribute to the predisposition of offspring to develop metabolic-syndrome-like phenotype in adulthood.	saturated	81-90	catenin beta 1	Rattus norvegicus	173-185
22898837-0	2012	[Effect of StarD7 and Wnt/beta-catenin signal pathway on the testosterone secretion stimulated by Annexin 5 in rat Leydig cells].	Testosterone	61-73	catenin beta 1	Rattus norvegicus	26-38
22898837-1	2012	OBJECTIVE: This research aims to study the internal mechanism that promotes the testosterone synthesis by StarD7 and Wnt/beta-catenin, and explores a  new regulatory pathway of testosterone synthesis.	Testosterone	80-92	catenin beta 1	Rattus norvegicus	121-133
22898837-1	2012	OBJECTIVE: This research aims to study the internal mechanism that promotes the testosterone synthesis by StarD7 and Wnt/beta-catenin, and explores a  new regulatory pathway of testosterone synthesis.	Testosterone	177-189	catenin beta 1	Rattus norvegicus	121-133
22898837-9	2012	It suggests that StarD7 and beta-catenin both regulate the effect of  Annexin 5 in testosterone production of rat Leydig cells.	Testosterone	83-95	catenin beta 1	Rattus norvegicus	28-40
22898837-10	2012	This regulation may active the Wnt/beta-catenin signal pathway, then increase the expression of the  StarD7, eventually raise the progress of the testosterone secretion in rat Leydig cells.	Testosterone	146-158	catenin beta 1	Rattus norvegicus	35-47
22634067-4	2012	Chronic citalopram treatment alleviated the depression-like behaviors and reversed the disruptions of the phosphorylated GSK3beta and beta-catenin in stressed rats.	Citalopram	8-18	catenin beta 1	Rattus norvegicus	134-146
22844359-7	2012	CPLA reduced beta-catenin and c-myc expression, but increased GSK-3beta expression, in preneoplastic lesions of the esophagus.	cpla	0-4	catenin beta 1	Rattus norvegicus	13-25
22747981-12	2012	CONCLUSION: The present study demonstrates that post-pMCAO estradiol treatment attenuates ischemic injury in both neurons and glia, events in which the PI3K/AKT/GSK3/beta-catenin pathway is at least partly involved.	Estradiol	59-68	catenin beta 1	Rattus norvegicus	166-178
22654119-5	2012	It has also been found that a significant elevation occurred in the expression of phosphorylated beta-catenin and focal adhesion kinase (FAK) at the site of tyrosine 397 in response to SW stimulation after the increasing expression of the integrin beta1 molecule.	Tyrosine	157-165	catenin beta 1	Rattus norvegicus	97-109
21755332-3	2012	Primary articular chondrocytes from eight week old rats were cultured and treated with LiCl for activation of beta-catenin.	Lithium Chloride	87-91	catenin beta 1	Rattus norvegicus	110-122
22290293-0	2012	The influence of fluoride on the expression of inhibitors of Wnt/beta-catenin signaling pathway in rat skin fibroblast Cells.	Fluorides	17-25	catenin beta 1	Rattus norvegicus	65-77
22374471-2	2012	The present study examines the effects of sulindac, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, on the oxidative status of rats that are prenatally exposed to valproic acid (VPA), which is used in an animal model of autism.	Sulindac	42-50	catenin beta 1	Rattus norvegicus	90-102
22374471-2	2012	The present study examines the effects of sulindac, a small molecule inhibitor of the Wnt/beta-catenin signaling pathway, on the oxidative status of rats that are prenatally exposed to valproic acid (VPA), which is used in an animal model of autism.	Valproic Acid	200-203	catenin beta 1	Rattus norvegicus	90-102
22374471-3	2012	Our data show that sulindac treatment downregulated the canonical Wnt/beta-catenin signaling pathway by enhancing the expression of Glycogen Synthase Kinase 3beta and attenuating the expression of beta-catenin in comparison to levels in VPA-treated rats.	Sulindac	19-27	catenin beta 1	Rattus norvegicus	70-82
22374471-3	2012	Our data show that sulindac treatment downregulated the canonical Wnt/beta-catenin signaling pathway by enhancing the expression of Glycogen Synthase Kinase 3beta and attenuating the expression of beta-catenin in comparison to levels in VPA-treated rats.	Sulindac	19-27	catenin beta 1	Rattus norvegicus	197-209
22484100-0	2012	Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats.	Methotrexate	48-60	catenin beta 1	Rattus norvegicus	15-27
22484100-5	2012	Concurrent administration of BIO, a GSK-3beta inhibitor that stabilises beta-catenin, partially abrogated the MTX-induced transient changes in osteogenic/adipogenic commitment, granulocyte/macrophage lineage differentiation and osteoclast number.	Methotrexate	110-113	catenin beta 1	Rattus norvegicus	72-84
22484100-6	2012	These findings demonstrate a potentially important role of Wnt/beta-catenin signalling in MTX chemotherapy-induced cellular changes to the bone marrow microenvironment.	Methotrexate	90-93	catenin beta 1	Rattus norvegicus	63-75
22472057-0	2012	The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3beta/beta-catenin activation in the medial prefrontal cortex.	Citalopram	14-24	catenin beta 1	Rattus norvegicus	101-113
22472057-4	2012	In the present study, we evaluated the role of the glycogen synthase kinase 3beta (GSK3beta)/beta-catenin signaling pathway in the antidepressant effect of citalopram in rats exposed to forced swim stress.	Citalopram	156-166	catenin beta 1	Rattus norvegicus	93-105
22472057-8	2012	Chronic citalopram treatment alleviated these behavioral changes in chronically stressed rats and normalized the downregulation of GSK3beta/beta-catenin signaling.	Citalopram	8-18	catenin beta 1	Rattus norvegicus	140-152
22472057-9	2012	Our results suggest that GSK3beta/beta-catenin signaling plays an important role in chronic but not acute stress-related depression and contributes, at least in part, to the antidepressant effects of citalopram in distinct brain regions associated with mood regulation.	Citalopram	200-210	catenin beta 1	Rattus norvegicus	34-46
22182938-10	2012	Moreover, leptin increased total level and nuclear translocation of beta-catenin, a primary substrate of GSK-3beta and a key regulator in controlling hippocampal neural progenitor cell proliferation, and reversed the inhibitory effects of DEX on beta-catenin.	Dexamethasone	239-242	catenin beta 1	Rattus norvegicus	68-80
22182938-10	2012	Moreover, leptin increased total level and nuclear translocation of beta-catenin, a primary substrate of GSK-3beta and a key regulator in controlling hippocampal neural progenitor cell proliferation, and reversed the inhibitory effects of DEX on beta-catenin.	Dexamethasone	239-242	catenin beta 1	Rattus norvegicus	246-258
22317924-6	2012	The normal membranous expression of beta-catenin was lower in GSH, and almost absent in CKH and SCC.	Glutathione	62-65	catenin beta 1	Rattus norvegicus	36-48
22317924-6	2012	The normal membranous expression of beta-catenin was lower in GSH, and almost absent in CKH and SCC.	CK-0944666	88-91	catenin beta 1	Rattus norvegicus	36-48
22320717-6	2012	Both 1-MT and EGCG significantly decreased the total number of aberrant crypt foci and beta-catenin-accumulated crypts, which overexpressed IDO protein.	epigallocatechin gallate	14-18	catenin beta 1	Rattus norvegicus	87-99
22294024-3	2012	Cilostazol             significantly reduced the expression of type II collagen and stimulated the accumulation             of beta-catenin in primary rat articular chondrocytes.	Cilostazol	0-10	catenin beta 1	Rattus norvegicus	127-139
21755332-11	2012	Finally, TUNEL staining revealed that LiCl-activated beta-catenin signalling led to increased cell apoptotic events in chondrocytes (p &lt; 0.05).	Lithium Chloride	38-42	catenin beta 1	Rattus norvegicus	53-65
22089197-8	2012	Active caspase 3 induced a loss of beta-catenin at the adherens junctions at 1 and 2 h followed by its recovery at 3 h. Transference of Bak peptide, an inducer of endogenous caspase 3 activation, induced hyperpermeability at 1 h followed by a significant decrease at 2 h. Inhibition of GSK-3beta and the transfection of beta-catenin vector increased Tcf-mediated transcription significantly (P &lt; 0.05).	bakuchiol	136-139	catenin beta 1	Rattus norvegicus	35-47
22089197-8	2012	Active caspase 3 induced a loss of beta-catenin at the adherens junctions at 1 and 2 h followed by its recovery at 3 h. Transference of Bak peptide, an inducer of endogenous caspase 3 activation, induced hyperpermeability at 1 h followed by a significant decrease at 2 h. Inhibition of GSK-3beta and the transfection of beta-catenin vector increased Tcf-mediated transcription significantly (P &lt; 0.05).	bakuchiol	136-139	catenin beta 1	Rattus norvegicus	320-332
21652696-0	2011	Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.	baicalin	0-8	catenin beta 1	Rattus norvegicus	96-108
22693536-0	2012	Astragaloside IV Downregulates beta-Catenin in Rat Keratinocytes to Counter LiCl-Induced Inhibition of Proliferation and Migration.	astragaloside	0-13	catenin beta 1	Rattus norvegicus	31-43
22693536-0	2012	Astragaloside IV Downregulates beta-Catenin in Rat Keratinocytes to Counter LiCl-Induced Inhibition of Proliferation and Migration.	Lithium Chloride	76-80	catenin beta 1	Rattus norvegicus	31-43
21764859-0	2011	Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats.	Naproxen	45-53	catenin beta 1	Rattus norvegicus	121-133
21764859-8	2011	Proliferation markers, proliferating cell nuclear antigen, cyclin D1, and beta-catenin in tumors of rats exposed to sulindac, naproxen, atorvastatin, and/or combinations showed a significant suppression.	Sulindac	116-124	catenin beta 1	Rattus norvegicus	74-86
21764859-8	2011	Proliferation markers, proliferating cell nuclear antigen, cyclin D1, and beta-catenin in tumors of rats exposed to sulindac, naproxen, atorvastatin, and/or combinations showed a significant suppression.	Naproxen	126-134	catenin beta 1	Rattus norvegicus	74-86
21764859-8	2011	Proliferation markers, proliferating cell nuclear antigen, cyclin D1, and beta-catenin in tumors of rats exposed to sulindac, naproxen, atorvastatin, and/or combinations showed a significant suppression.	Atorvastatin	136-148	catenin beta 1	Rattus norvegicus	74-86
21657945-0	2011	Differential expression of the Wnt/beta-catenin pathway in the genital tubercle (GT) of fetal male rat following maternal exposure to di-n-butyl phthalate (DBP).	Dibutyl Phthalate	134-154	catenin beta 1	Rattus norvegicus	35-47
21657945-0	2011	Differential expression of the Wnt/beta-catenin pathway in the genital tubercle (GT) of fetal male rat following maternal exposure to di-n-butyl phthalate (DBP).	Dibutyl Phthalate	156-159	catenin beta 1	Rattus norvegicus	35-47
21657945-7	2011	These findings, for the first time, indicate that DBP may affect the development of GT by down-regulating the Wnt/beta-catenin pathway in fetal male rats.	GT	84-86	catenin beta 1	Rattus norvegicus	114-126
21657945-7	2011	These findings, for the first time, indicate that DBP may affect the development of GT by down-regulating the Wnt/beta-catenin pathway in fetal male rats.	wnt	110-113	catenin beta 1	Rattus norvegicus	114-126
21627639-0	2012	Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects.	Fluoxetine	26-36	catenin beta 1	Rattus norvegicus	109-121
21627639-0	2012	Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects.	Ketanserin	41-51	catenin beta 1	Rattus norvegicus	109-121
21627639-5	2012	Expression of beta-catenin was increased in total hippocampal homogenate and in the membrane fraction, but unchanged in the nuclear fraction after combined treatment with fluoxetine + ketanserin.	Fluoxetine	171-181	catenin beta 1	Rattus norvegicus	14-26
21627639-5	2012	Expression of beta-catenin was increased in total hippocampal homogenate and in the membrane fraction, but unchanged in the nuclear fraction after combined treatment with fluoxetine + ketanserin.	Ketanserin	184-194	catenin beta 1	Rattus norvegicus	14-26
22115893-1	2012	Our findings reported so far demonstrate that silibinin modulates gut microbial enzymes, colonic oxidative stress and Wnt/beta-catenin signaling, to exert its antiproliferative effect against 1,2 di-methylhydrazine (DMH) induced colon carcinogenesis.	Silybin	46-55	catenin beta 1	Rattus norvegicus	122-134
22034513-0	2012	Transglutaminase 2-mediated activation of beta-catenin signaling has a critical role in warfarin-induced vascular calcification.	Warfarin	88-96	catenin beta 1	Rattus norvegicus	42-54
22034513-3	2012	METHODS AND RESULTS: Warfarin-induced calcification in rat A10 VSMCs is associated with the activation of beta-catenin signaling and is independent of oxidative stress.	Warfarin	21-29	catenin beta 1	Rattus norvegicus	106-118
22034513-4	2012	The canonical beta-catenin inhibitor Dkk1, but not the Wnt antagonist Wif-1, prevents warfarin-induced activation of beta-catenin, calcification, and osteogenic transdifferentiation in VSMCs.	Warfarin	86-94	catenin beta 1	Rattus norvegicus	14-26
22034513-4	2012	The canonical beta-catenin inhibitor Dkk1, but not the Wnt antagonist Wif-1, prevents warfarin-induced activation of beta-catenin, calcification, and osteogenic transdifferentiation in VSMCs.	Warfarin	86-94	catenin beta 1	Rattus norvegicus	117-129
22034513-8	2012	CONCLUSIONS: TG2 is a critical mediator of warfarin-induced vascular calcification that acts through the activation of beta-catenin signaling in VSMCs.	Warfarin	43-51	catenin beta 1	Rattus norvegicus	119-131
22034513-9	2012	Inhibition of canonical beta-catenin pathway or TG2 activity prevents warfarin-regulated calcification, identifying the TG2/beta-catenin axis as a novel therapeutic target in vascular calcification.	Warfarin	70-78	catenin beta 1	Rattus norvegicus	24-36
22034513-9	2012	Inhibition of canonical beta-catenin pathway or TG2 activity prevents warfarin-regulated calcification, identifying the TG2/beta-catenin axis as a novel therapeutic target in vascular calcification.	Warfarin	70-78	catenin beta 1	Rattus norvegicus	124-136
22360497-8	2012	In vitro studies of the DFCs showed that LiCl stimulation caused beta-catenin, which was mainly located in the cell membrane and cytoplasm of DFCs, to be immediately transferred to the nucleus and led to the inhibition of proliferation at 12 and 24 hr.	Lithium Chloride	41-45	catenin beta 1	Rattus norvegicus	65-77
22360497-9	2012	LiCl treatment also downregulated the levels of phosphorylated-beta-catenin, while upregulating the levels of total beta-catenin, nuclear beta-catenin, osteocalcin, runt-related transcription factor 2, and collagen type I.	Lithium Chloride	0-4	catenin beta 1	Rattus norvegicus	63-75
22360497-9	2012	LiCl treatment also downregulated the levels of phosphorylated-beta-catenin, while upregulating the levels of total beta-catenin, nuclear beta-catenin, osteocalcin, runt-related transcription factor 2, and collagen type I.	Lithium Chloride	0-4	catenin beta 1	Rattus norvegicus	116-128
22360497-9	2012	LiCl treatment also downregulated the levels of phosphorylated-beta-catenin, while upregulating the levels of total beta-catenin, nuclear beta-catenin, osteocalcin, runt-related transcription factor 2, and collagen type I.	Lithium Chloride	0-4	catenin beta 1	Rattus norvegicus	116-128
22360497-10	2012	In addition, LiCl enhanced the beta-catenin/T-cell factor luciferase activity and alkaline phosphatase activity.	Lithium Chloride	13-17	catenin beta 1	Rattus norvegicus	31-43
22917468-0	2012	Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/beta-catenin pathways.	puerarin	0-8	catenin beta 1	Rattus norvegicus	112-124
22917468-4	2012	Furthermore, puerarin was shown to elevate levels of phospho-p38 mitogen-activated protein kinase (MAPK) and beta-catenin proteins in a time-dependent manner.	puerarin	13-21	catenin beta 1	Rattus norvegicus	109-121
22917468-7	2012	Taken together, ER, p38 MAPK, and Wnt/beta-catenin pathways were involved in puerarin-stimulated osteoblasts differentiation and bone formation.	puerarin	77-85	catenin beta 1	Rattus norvegicus	38-50
22745681-8	2012	Troglitazone not only attenuated TGF-beta1-induced phosphorylation of Akt and glycogen synthase kinase (GSK)-3beta, but also inhibited nuclear translocation of beta-catenin, phosphorylation of Smad2 and Smad3 and upregulation of the EMT-associated transcription factor SNAI1.	Troglitazone	0-12	catenin beta 1	Rattus norvegicus	160-172
22745681-9	2012	These results demonstrate inhibitory actions of troglitazone on TGF-beta1-induced EMT in AEC via a PPARgamma-independent mechanism likely through inhibition of beta-catenin-dependent signaling downstream of TGF-beta1, supporting a role for interactions between TGF-beta and Wnt/beta-catenin signaling pathways in EMT.	Troglitazone	48-60	catenin beta 1	Rattus norvegicus	160-172
22745681-9	2012	These results demonstrate inhibitory actions of troglitazone on TGF-beta1-induced EMT in AEC via a PPARgamma-independent mechanism likely through inhibition of beta-catenin-dependent signaling downstream of TGF-beta1, supporting a role for interactions between TGF-beta and Wnt/beta-catenin signaling pathways in EMT.	Troglitazone	48-60	catenin beta 1	Rattus norvegicus	278-290
21659659-9	2011	In newborn rats, exposure to 90% oxygen for 14 days resulted in activation of beta-catenin signaling, decreased alveolarization and vascular development, and physiological and histological evidence of pulmonary hypertension (PH).	Oxygen	33-39	catenin beta 1	Rattus norvegicus	78-90
21764859-0	2011	Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats.	Atorvastatin	15-27	catenin beta 1	Rattus norvegicus	121-133
21764859-0	2011	Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/beta-catenin/cyclin D1 signaling pathway in rats.	Sulindac	33-41	catenin beta 1	Rattus norvegicus	121-133
22190524-16	2011	CONCLUSION: Results suggest that the Wnt/beta-catenin signaling is activated in the MSCs cultured with ORS and excessive activation of Wnt/beta-catenin signaling can promote MSCs aging.	World Health Organization oral rehydration solution	103-106	catenin beta 1	Rattus norvegicus	41-53
21818840-7	2011	Exposure to 30 mM glucose decreased mRNA levels of Copper-Zinc superoxide dismutase, manganese superoxide dismutase, extracellular superoxide dismutase, Catalase, Gpx-1, Nrf2, poly-ADP ribose polymerase, B-cell leukemia/lymphoma protein 2, and beta-Catenin genes in cranial neural crest explant cultures.	Glucose	18-25	catenin beta 1	Rattus norvegicus	244-256
21540029-7	2011	In the rat cornea, the levels of total beta-catenin were significantly up-regulated 8 h after the topical administration of BAC.	Benzalkonium Compounds	124-127	catenin beta 1	Rattus norvegicus	39-51
21652696-0	2011	Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.	flavone	12-19	catenin beta 1	Rattus norvegicus	96-108
21652696-6	2011	In contrast, baicalin promoted osteoblastic differentiation via the activation of the Wnt/beta-catenin signaling pathway; the activation resulted in the phosphorylation of glycogen synthase kinase 3beta and, subsequently, induced the nuclear accumulation of the beta-catenin, leading to the transcription activation of Wnt-targeted genes for osteogenesis.	baicalin	13-21	catenin beta 1	Rattus norvegicus	90-102
21652696-6	2011	In contrast, baicalin promoted osteoblastic differentiation via the activation of the Wnt/beta-catenin signaling pathway; the activation resulted in the phosphorylation of glycogen synthase kinase 3beta and, subsequently, induced the nuclear accumulation of the beta-catenin, leading to the transcription activation of Wnt-targeted genes for osteogenesis.	baicalin	13-21	catenin beta 1	Rattus norvegicus	262-274
21652696-7	2011	The baicalin-induced osteogenic effects were fully abolished by DKK-1, a blocker of Wnt/beta-catenin receptor.	baicalin	4-12	catenin beta 1	Rattus norvegicus	88-100
21619414-7	2011	Fluoxetine reversed the expression of cyclic guanosine 3",5"-monophosphate-dependent kinase I, BMPR2, phospho-Smad1, beta-catenin, and reduced the expression of caspase 3 in rat lungs.	Fluoxetine	0-10	catenin beta 1	Rattus norvegicus	117-129
21520058-5	2011	Overexpression of SH2B1beta reduces N-cadherin levels and increased phosphotyrosine 654 beta-catenin, leading to increased nerve growth factor-induced neurite initiation in PC12 cells, an established model for neuronal differentiation.	Phosphotyrosine	68-83	catenin beta 1	Rattus norvegicus	88-100
21216390-12	2011	Increased E-cadherin and beta-catenin immunoexpression was recorded in the lycopene treated group in comparison to the carcinogen group.	Lycopene	75-83	catenin beta 1	Rattus norvegicus	25-37
20694826-6	2011	Cf-PS treatment induced the translocation of beta-catenin, an effector of the Wnt signaling pathway, from the cytosol to the nucleus and increased the expression of cyclinD1 and c-myc.	CFP protocol	0-5	catenin beta 1	Rattus norvegicus	45-57
21695899-0	2011	[Effect of subchronic fluoride exposure on pathologic change and beta-catenin expression in rat bone tissue].	Fluorides	22-30	catenin beta 1	Rattus norvegicus	65-77
21695899-1	2011	OBJECTIVE: To explore the effect of subchronic fluoride exposure on the expression of beta-catenin in the bone of rats and the role of beta-catenin in skeletal damage.	Fluorides	47-55	catenin beta 1	Rattus norvegicus	86-98
21695899-11	2011	CONCLUSION: It was suggested that beta-catenin could play important role in bone sclerosis of subchronic fluoride exposure.	Fluorides	105-113	catenin beta 1	Rattus norvegicus	34-46
21316358-9	2011	GSK3beta activation was verified because there was a decrease in un-phospho-beta-catenin-Ser(33/37)/beta-catenin in the TNF-4.0 group, a specific outcome for GSK3beta activation.	Serine	89-92	catenin beta 1	Rattus norvegicus	76-88
21316358-9	2011	GSK3beta activation was verified because there was a decrease in un-phospho-beta-catenin-Ser(33/37)/beta-catenin in the TNF-4.0 group, a specific outcome for GSK3beta activation.	Serine	89-92	catenin beta 1	Rattus norvegicus	100-112
21316358-10	2011	In the SB216763+TNF group, un-phospho-beta-catenin-Ser(33/37) was similar to Control, indicating prevention of TNF-induced GSK3beta activation.	Serine	51-54	catenin beta 1	Rattus norvegicus	38-50
21316358-12	2011	In the SB216763+TNF-24h and TDZD-8+TNF-24h groups, un-phospho-beta-catenin-Ser(33/37) was greater than in the Control, indicating continued inhibition of GSK3beta.	tdzd	28-32	catenin beta 1	Rattus norvegicus	62-74
21316358-12	2011	In the SB216763+TNF-24h and TDZD-8+TNF-24h groups, un-phospho-beta-catenin-Ser(33/37) was greater than in the Control, indicating continued inhibition of GSK3beta.	Serine	75-78	catenin beta 1	Rattus norvegicus	62-74
21307750-11	2011	beta-Catenin gene expression construct or recombinant beta-catenin protein attenuated BAK-induced monolayer hyperpermeability significantly (p&lt;0.05).	bakuchiol	86-89	catenin beta 1	Rattus norvegicus	0-12
21436889-9	2011	These results indicate a functional relationship between prostaglandins and the Wnt/beta-catenin signaling pathway in bone.	Prostaglandins	57-71	catenin beta 1	Rattus norvegicus	84-96
20978740-13	2011	NAC treatment reduced HNE and 3-nitrotyrosine levels and attenuated the upregulation of LRP6, beta-catenin and CTGF in diabetic rat retina.	Acetylcysteine	0-3	catenin beta 1	Rattus norvegicus	94-106
21118797-1	2011	Lithium is an activator of beta-catenin signaling, and beta-catenin mediates bone acquisition in response to mechanical loading in the bone.	Lithium	0-7	catenin beta 1	Rattus norvegicus	27-39
21118797-5	2011	Lithium increased beta-catenin expression and cell proliferation in expanding sutures.	Lithium	0-7	catenin beta 1	Rattus norvegicus	18-30
21118797-7	2011	These results suggested that beta-catenin regulates proliferation of osteoprogenitors and maturation of osteoblasts during midpalatal suture expansion osteogenesis, and that lithium enhances bone regeneration by elevating beta-catenin expression.	Lithium	174-181	catenin beta 1	Rattus norvegicus	222-234
21307750-11	2011	beta-Catenin gene expression construct or recombinant beta-catenin protein attenuated BAK-induced monolayer hyperpermeability significantly (p&lt;0.05).	bakuchiol	86-89	catenin beta 1	Rattus norvegicus	54-66
21404708-0	2011	[Effects of polychlorinated biphenyl on the expressions of c-fos, c-Myc and beta-catenin in the rat testis].	Polychlorinated Biphenyls	12-36	catenin beta 1	Rattus norvegicus	76-88
21404708-6	2011	The expression of beta-catenin was downregulated in the 0.1 mg/kg PCB group, with significant differences from the other groups (P &lt; 0.01), but it was higher in the 1 mg/kg PCB than in the control and 10 mg/kg PCB groups (P &lt; 0.01).	Polychlorinated Biphenyls	66-69	catenin beta 1	Rattus norvegicus	18-30
21404708-6	2011	The expression of beta-catenin was downregulated in the 0.1 mg/kg PCB group, with significant differences from the other groups (P &lt; 0.01), but it was higher in the 1 mg/kg PCB than in the control and 10 mg/kg PCB groups (P &lt; 0.01).	Polychlorinated Biphenyls	176-179	catenin beta 1	Rattus norvegicus	18-30
21404708-6	2011	The expression of beta-catenin was downregulated in the 0.1 mg/kg PCB group, with significant differences from the other groups (P &lt; 0.01), but it was higher in the 1 mg/kg PCB than in the control and 10 mg/kg PCB groups (P &lt; 0.01).	Polychlorinated Biphenyls	176-179	catenin beta 1	Rattus norvegicus	18-30
21404708-7	2011	CONCLUSION: PCB causes changes in the phenotype of the testis tissue, and the abnormal expressions of c-fos, c-Myc and beta-catenin are closely related to the PCB-induced testis injury.	Polychlorinated Biphenyls	159-162	catenin beta 1	Rattus norvegicus	119-131
21510291-8	2011	The expression of COX-1 and beta-catenin also reduced in mofezolac-added groups simultaneously (p &lt; 0.05).	mofezolac	57-66	catenin beta 1	Rattus norvegicus	28-40
20886368-0	2011	The role of beta-catenin signaling pathway on proliferation of rats neural stem cells after hyperbaric oxygen therapy in vitro.	Oxygen	103-109	catenin beta 1	Rattus norvegicus	12-24
21712954-13	2011	Moreover, the expression of gamma-H2A.X, a molecular marker of DNA damage response, p16(INK4a), p53, and p21 is increased in senescent MSCs induced with ORS, and is also reversed by DKK1 or by beta-catenin siRNA.	World Health Organization oral rehydration solution	153-156	catenin beta 1	Rattus norvegicus	193-205
21128180-0	2011	Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and beta-catenin proteins.	Dimethylhydrazines	66-69	catenin beta 1	Rattus norvegicus	113-125
21128180-4	2011	The results showed a significant increase in protein expression for K-ras and beta-catenin in tumors of DMH-treated rats.	Dimethylhydrazines	104-107	catenin beta 1	Rattus norvegicus	78-90
20734317-0	2010	Demethylation of specific Wnt/beta-catenin pathway genes and its upregulation in rat brain induced by prenatal valproate exposure.	Valproic Acid	111-120	catenin beta 1	Rattus norvegicus	30-42
20734317-3	2010	The aim of this study was to investigate the methylation modification and its effects on the activity of Wnt/beta-catenin pathway in the rat brain prenatally exposed to VPA.	Valproic Acid	169-172	catenin beta 1	Rattus norvegicus	109-121
20499363-0	2010	Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/beta-catenin canonical Wnt signaling.	phenolic acid	22-36	catenin beta 1	Rattus norvegicus	70-82
20533544-4	2010	RESULTS: We found that beta-catenin mRNA and protein were expressed in discs in vivo and that rat NP cells exhibited increased beta-catenin mRNA and protein upon stimulation with lithium chloride, a known activator of WNT signaling.	Lithium Chloride	179-195	catenin beta 1	Rattus norvegicus	23-35
20533544-4	2010	RESULTS: We found that beta-catenin mRNA and protein were expressed in discs in vivo and that rat NP cells exhibited increased beta-catenin mRNA and protein upon stimulation with lithium chloride, a known activator of WNT signaling.	Lithium Chloride	179-195	catenin beta 1	Rattus norvegicus	127-139
20061362-0	2010	Dietary intake of pterostilbene, a constituent of blueberries, inhibits the beta-catenin/p65 downstream signaling pathway and colon carcinogenesis in rats.	pterostilbene	18-31	catenin beta 1	Rattus norvegicus	76-88
20537993-3	2010	Our aim was to explore the modulatory effect of silibinin on beta-catenin expression employing 1,2-dimethylhydrazine (DMH) induced colon cancer in male Wistar rats as an experimental model during the different stages of carcinogenesis.	Silybin	48-57	catenin beta 1	Rattus norvegicus	61-73
20537993-3	2010	Our aim was to explore the modulatory effect of silibinin on beta-catenin expression employing 1,2-dimethylhydrazine (DMH) induced colon cancer in male Wistar rats as an experimental model during the different stages of carcinogenesis.	1,2-Dimethylhydrazine	118-121	catenin beta 1	Rattus norvegicus	61-73
20537993-8	2010	Silibinin supplementation to DMH-treated rats restored the levels of GSH-dependent enzymes and decreased the levels of beta-catenin, PCNA, argyrophilic nucleolar organizer regions and cyclin D1.	Silybin	0-9	catenin beta 1	Rattus norvegicus	119-131
20537993-8	2010	Silibinin supplementation to DMH-treated rats restored the levels of GSH-dependent enzymes and decreased the levels of beta-catenin, PCNA, argyrophilic nucleolar organizer regions and cyclin D1.	1,2-Dimethylhydrazine	29-32	catenin beta 1	Rattus norvegicus	119-131
20537993-9	2010	Mechanistically silibinin inhibits DMH-induced colon carcinogenesis by modulating the Wnt/beta-catenin pathway and glutathione redox system.	Silybin	16-25	catenin beta 1	Rattus norvegicus	90-102
20537993-9	2010	Mechanistically silibinin inhibits DMH-induced colon carcinogenesis by modulating the Wnt/beta-catenin pathway and glutathione redox system.	1,2-Dimethylhydrazine	35-38	catenin beta 1	Rattus norvegicus	90-102
20372961-7	2010	Dexamethasone-induced IEC-6 cells differentiation caused a 2.5-fold increase in miR-30e expression, and upon beta-catenin siRNA transfection, miR-30e increased 1.3-fold.	Dexamethasone	0-13	catenin beta 1	Rattus norvegicus	109-121
20623542-10	2010	Consistent with the hypothesis that delta-catenin promotes the interaction of the destruction complex molecules, cycloheximide treatment of cells overexpressing delta-catenin showed enhanced beta-catenin turnover.	Cycloheximide	113-126	catenin beta 1	Rattus norvegicus	191-203
20507283-2	2010	In the present study, we have used another potent PPAR-gamma agonist, rosiglitazone, to treat Han:SPRD rats, a slowly progressive ADPKD (autosomal dominant PKD) animal model, and confirmed that short-term treatment was able to delay the progression of kidney cysts and protect renal function, which may relate to down-regulating the abnormally activated beta-catenin signalling pathway and its anti-inflammatory and anti-fibrosis effects.	Rosiglitazone	70-83	catenin beta 1	Rattus norvegicus	354-366
20061362-7	2010	Overall analyses indicated that pterostilbene reduced colon tumor multiplicity of non-invasive adenocarcinomas, lowered proliferating cell nuclear antigen and downregulated the expression of beta-catenin and cyclin D1.	pterostilbene	32-45	catenin beta 1	Rattus norvegicus	191-203
20200936-0	2010	Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling.	osthol	0-7	catenin beta 1	Rattus norvegicus	82-94
20079359-4	2010	We demonstrated RBX treatment suppressed high glucose induced PKC-betaII activation and phosphorylation of beta-catenin in vivo and in vitro experiments.	rbx	16-19	catenin beta 1	Rattus norvegicus	107-119
20079359-4	2010	We demonstrated RBX treatment suppressed high glucose induced PKC-betaII activation and phosphorylation of beta-catenin in vivo and in vitro experiments.	Glucose	46-53	catenin beta 1	Rattus norvegicus	107-119
20549453-6	2010	demonstrated in an aortic constriction-induced acute hypertrophy model using 6-week-old Wister rats that if GSK-3b is inhibited by LiCl up-regulated beta-catenin expression and additional hypertrophy were observed.	Lithium Chloride	131-135	catenin beta 1	Rattus norvegicus	149-161
20549453-7	2010	They suggested that Li(2+) had an additive effect on pressure overload-induced hypertrophy through the GSK-3beta-beta-catenin pathway.	li(2+)	20-26	catenin beta 1	Rattus norvegicus	113-125
20200936-8	2010	In vitro studies demonstrated that Osthole activated Wnt/beta-catenin signaling, increased Bmp2 expression, and stimulated osteoblast differentiation.	osthol	35-42	catenin beta 1	Rattus norvegicus	57-69
20200936-9	2010	Targeted deletion of the beta-catenin and Bmp2 genes abolished the stimulatory effect of Osthole on osteoblast differentiation.	osthol	89-96	catenin beta 1	Rattus norvegicus	25-37
20200936-10	2010	Since deletion of the Bmp2 gene did not affect Osthole-induced beta-catenin expression and the deletion of the beta-catenin gene inhibited Osthole-regulated Bmp2 expression in osteoblasts, we propose that Osthole acts through beta-catenin-BMP signaling to promote osteoblast differentiation.	osthol	139-146	catenin beta 1	Rattus norvegicus	111-123
20200936-10	2010	Since deletion of the Bmp2 gene did not affect Osthole-induced beta-catenin expression and the deletion of the beta-catenin gene inhibited Osthole-regulated Bmp2 expression in osteoblasts, we propose that Osthole acts through beta-catenin-BMP signaling to promote osteoblast differentiation.	osthol	139-146	catenin beta 1	Rattus norvegicus	111-123
20200936-10	2010	Since deletion of the Bmp2 gene did not affect Osthole-induced beta-catenin expression and the deletion of the beta-catenin gene inhibited Osthole-regulated Bmp2 expression in osteoblasts, we propose that Osthole acts through beta-catenin-BMP signaling to promote osteoblast differentiation.	osthol	139-146	catenin beta 1	Rattus norvegicus	111-123
20200936-10	2010	Since deletion of the Bmp2 gene did not affect Osthole-induced beta-catenin expression and the deletion of the beta-catenin gene inhibited Osthole-regulated Bmp2 expression in osteoblasts, we propose that Osthole acts through beta-catenin-BMP signaling to promote osteoblast differentiation.	osthol	139-146	catenin beta 1	Rattus norvegicus	111-123
19931241-0	2010	Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.	4-Nitroquinoline-1-oxide	83-107	catenin beta 1	Rattus norvegicus	4-16
20200986-0	2010	A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/beta-catenin signaling.	Ethanol	11-18	catenin beta 1	Rattus norvegicus	133-145
20200986-12	2010	Ethanol treatment inactivated TCF/LEF gene transcription, eliminated beta-catenin nuclear translocation in osteoblasts, and reciprocally suppressed osteoblastogenesis and enhanced adipogenesis.	Ethanol	0-7	catenin beta 1	Rattus norvegicus	69-81
20346115-9	2010	Total number of ACF and AC, and multicrypt of ACF, and the expression of beta-catenin and COX-2 reduced significantly (p &lt; 0.05) in all the groups treated with GBR (G2, G3 and G4) compared to the control group (G1).	glutathione-bicarbonate-Ringer solution	163-166	catenin beta 1	Rattus norvegicus	73-85
20042609-0	2010	Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.	Phosphatidylinositols	196-216	catenin beta 1	Rattus norvegicus	284-296
20023173-8	2010	Finally, immunoprecipitation and immunoblot analyses demonstrated increased tyrosine phosphorylation of VE-cadherin, beta-catenin, and p190RhoGAP proteins, as well as decreased association between p120-catenin and VE-cadherin proteins.	Tyrosine	76-84	catenin beta 1	Rattus norvegicus	117-129
20006464-10	2010	Fasudil treatment of diabetic rats resulted in attenuated MYPT1 phosphorylation, decreased ROCK1 and alpha-SMA expression, increased E-cadherin and membrane beta-catenin expression, and reduced ROCK1 and total beta-catenin mRNA expression, increased expression of E-cadherin mRNA.	fasudil	0-7	catenin beta 1	Rattus norvegicus	157-169
20006464-10	2010	Fasudil treatment of diabetic rats resulted in attenuated MYPT1 phosphorylation, decreased ROCK1 and alpha-SMA expression, increased E-cadherin and membrane beta-catenin expression, and reduced ROCK1 and total beta-catenin mRNA expression, increased expression of E-cadherin mRNA.	fasudil	0-7	catenin beta 1	Rattus norvegicus	210-222
19782693-8	2009	Kinase-inactive GSK-3beta mutant and BIO treatments attenuated dexamethasone-induced inhibition of beta-catenin, Runx2 abundance, and osteoblast differentiation but suppressed glucocorticoid-induced apoptosis of cell cultures.	Dexamethasone	63-76	catenin beta 1	Rattus norvegicus	99-111
19726620-8	2010	DHT increased total levels of beta-catenin protein, which accumulated in nuclei in vivo.	Dihydrotestosterone	0-3	catenin beta 1	Rattus norvegicus	30-42
19856966-0	2009	(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate.	WAY-262611	0-64	catenin beta 1	Rattus norvegicus	77-89
19856966-1	2009	A high-throughput screening campaign to discover small molecule leads for the treatment of bone disorders concluded with the discovery of a compound with a 2-aminopyrimidine template that targeted the Wnt beta-catenin cellular messaging system.	2-aminopyrimidine	156-173	catenin beta 1	Rattus norvegicus	205-217
19655246-5	2010	In this study, we evaluated the expression of APC and its association with beta-catenin signaling pathway, following the induction of an excitotoxic lesion by kainic acid (KA) injection, which cause pyramidal cell degeneration.	Kainic Acid	159-170	catenin beta 1	Rattus norvegicus	75-87
20472150-8	2010	Therefore, GSK-3beta/beta-catenin pathway may be important in the reciprocal actions of GCs and Li on ADP proliferation.	Adenosine Diphosphate	102-105	catenin beta 1	Rattus norvegicus	21-33
19879238-7	2009	Lithium chloride transiently activated beta-catenin expression and subsequently decreased beta-catenin level and at last inhibited MSCs to differentiate into airway epithelium.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	39-51
19879238-7	2009	Lithium chloride transiently activated beta-catenin expression and subsequently decreased beta-catenin level and at last inhibited MSCs to differentiate into airway epithelium.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	90-102
19473345-11	2009	Administration of choline before ischaemia not only increased beta-catenin expression, but also strengthened the association between beta-catenin and the M(3) mAChR.	Choline	18-25	catenin beta 1	Rattus norvegicus	62-74
19473345-12	2009	However, blockade of M(3) mAChR by 4-DAMP completely inhibited the effect of choline on the expression of beta-catenin.	Choline	77-84	catenin beta 1	Rattus norvegicus	106-118
19473345-11	2009	Administration of choline before ischaemia not only increased beta-catenin expression, but also strengthened the association between beta-catenin and the M(3) mAChR.	Choline	18-25	catenin beta 1	Rattus norvegicus	133-145
19615436-6	2009	In addition, following Cd exposure, E-cadherin/beta-catenin complex disassembles in both cell types, with fetal cells being influenced at higher doses.	Cadmium	23-25	catenin beta 1	Rattus norvegicus	47-59
19166962-8	2009	Pretreatment with PP2 abrogated this OA-induced tyrosine phosphorylation of p120 catenin and beta-catenin and restored the association of N-cadherin with p120 catenin and that of beta-catenin with alpha-catenin.	pp2	18-21	catenin beta 1	Rattus norvegicus	93-105
19417676-7	2009	The results showed that 1,2-dimethylhydrazine significantly increased total aberrant crypt foci formation, total number of dysplastic foci, beta-catenin accumulated crypts and proliferating cell nuclear antigen labeling index in the colon, and enhanced lipid peroxidation markers and decreased enzymic antioxidant activities in the plasma and erythrocyte lysate as compared with untreated controls.	1,2-Dimethylhydrazine	24-45	catenin beta 1	Rattus norvegicus	140-152
19460432-7	2009	These findings suggest that TAZ is not only involved in the signal pathway of BMP-2-induced osteoblastic differentiation, but also involved in the signaling pathway of DEX-induced osteoblastic differentiation, supporting the notion that TAZ is a convergence point of two signaling pathways, BMP-2 signaling pathway and Wnt-beta-catenin signaling pathway.	Dexamethasone	168-171	catenin beta 1	Rattus norvegicus	323-335
19166962-8	2009	Pretreatment with PP2 abrogated this OA-induced tyrosine phosphorylation of p120 catenin and beta-catenin and restored the association of N-cadherin with p120 catenin and that of beta-catenin with alpha-catenin.	pp2	18-21	catenin beta 1	Rattus norvegicus	179-191
19166962-8	2009	Pretreatment with PP2 abrogated this OA-induced tyrosine phosphorylation of p120 catenin and beta-catenin and restored the association of N-cadherin with p120 catenin and that of beta-catenin with alpha-catenin.	Tyrosine	48-56	catenin beta 1	Rattus norvegicus	93-105
19306293-6	2009	Endothelial cells exposed to VEGF and histamine had an increased level of nuclear beta-catenin, which was sensitive to inhibition of the PI3-kinase signaling pathway.	Histamine	38-47	catenin beta 1	Rattus norvegicus	82-94
19464575-0	2009	2,2",4,4",5,5"-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.	2,4,5,2',4',5'-hexachlorobiphenyl	0-33	catenin beta 1	Rattus norvegicus	107-119
19464575-11	2009	Protein levels of E-cadherin and beta-catenin were partially restored with lysosomal inhibitor leupeptin, thus suggesting a possible role of lysosomes in the observed degradation of adherens junction proteins.	leupeptin	95-104	catenin beta 1	Rattus norvegicus	33-45
19505573-6	2009	CPT-cAMP-treatment induced GSK3 beta phosphorylation and beta-catenin-mediated transcriptional activity.	Cyclic AMP	4-8	catenin beta 1	Rattus norvegicus	57-69
19505573-8	2009	The effects of CPT-cAMP on beta-catenin-mediated transcription, cell metabolism and mRNA expression were mimicked by the cAMP-elevating agent PGE(2), providing a physiologically relevant context for our studies.	cpt-camp	15-23	catenin beta 1	Rattus norvegicus	27-39
19505573-8	2009	The effects of CPT-cAMP on beta-catenin-mediated transcription, cell metabolism and mRNA expression were mimicked by the cAMP-elevating agent PGE(2), providing a physiologically relevant context for our studies.	Cyclic AMP	19-23	catenin beta 1	Rattus norvegicus	27-39
19505573-8	2009	The effects of CPT-cAMP on beta-catenin-mediated transcription, cell metabolism and mRNA expression were mimicked by the cAMP-elevating agent PGE(2), providing a physiologically relevant context for our studies.	Prostaglandins E	142-145	catenin beta 1	Rattus norvegicus	27-39
19148749-0	2009	Wnt/beta-catenin/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure.	Ethylnitrosourea	116-137	catenin beta 1	Rattus norvegicus	4-16
19148749-2	2009	In the present study, we report the first evidence that Wnt/beta-catenin/Tcf signaling pathway is constitutively activated in experimental gliomas induced by single transplacental dose of N-ethyl-N-nitrosourea (ENU).	tcf	73-76	catenin beta 1	Rattus norvegicus	60-72
19148749-2	2009	In the present study, we report the first evidence that Wnt/beta-catenin/Tcf signaling pathway is constitutively activated in experimental gliomas induced by single transplacental dose of N-ethyl-N-nitrosourea (ENU).	Ethylnitrosourea	188-209	catenin beta 1	Rattus norvegicus	60-72
19306293-0	2009	Differential role of beta-catenin in VEGF and histamine-induced MMP-2 production in microvascular endothelial cells.	Histamine	46-55	catenin beta 1	Rattus norvegicus	21-33
19306293-3	2009	We hypothesized that beta-catenin acts as a positive regulator of MMP-2 and MT1-MMP transcription following VEGF or histamine stimulation.	Histamine	116-125	catenin beta 1	Rattus norvegicus	21-33
19306293-10	2009	While both VEGF and histamine increase nuclear beta-catenin and MMP-2 production, the role of beta-catenin in MMP-2 regulation differs between the two stimuli.	Histamine	20-29	catenin beta 1	Rattus norvegicus	47-59
19778218-0	2009	Long-term exposure to various types of dietary fat modulates acrylamide-induced preneoplastic lesions of colon mucosa through Wnt/beta-catenin signaling in rats.	Acrylamide	61-71	catenin beta 1	Rattus norvegicus	130-142
19005466-0	2009	Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway.	Lithium	20-27	catenin beta 1	Rattus norvegicus	144-156
19073877-0	2009	Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells.	Isoflavones	0-14	catenin beta 1	Rattus norvegicus	103-115
19005466-0	2009	Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway.	tcf	157-160	catenin beta 1	Rattus norvegicus	144-156
19005466-8	2009	The recovery effect of Li was abolished by quercetin, an inhibitor of beta-catenin/TCF pathway.	Quercetin	43-52	catenin beta 1	Rattus norvegicus	70-82
19005466-8	2009	The recovery effect of Li was abolished by quercetin, an inhibitor of beta-catenin/TCF pathway.	tcf	83-86	catenin beta 1	Rattus norvegicus	70-82
19005466-11	2009	These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders.	Dexamethasone	119-122	catenin beta 1	Rattus norvegicus	41-53
19005466-11	2009	These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders.	Adenosine Diphosphate	133-136	catenin beta 1	Rattus norvegicus	41-53
19068119-0	2008	Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway.	Valproic Acid	0-13	catenin beta 1	Rattus norvegicus	105-117
18616682-0	2008	beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	109-156	catenin beta 1	Rattus norvegicus	0-12
18786620-7	2008	Calpastatin overexpression inhibited the sAbeta-promoted degradation of fodrin, protein kinase Cepsilon, beta-catenin (membrane structural proteins and proteins involved in signal transduction pathways), and prevented the sAbeta-induced alteration of neurite structure (manifested by varicosities).	sabeta	41-47	catenin beta 1	Rattus norvegicus	105-117
18616682-0	2008	beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	158-162	catenin beta 1	Rattus norvegicus	0-12
18616682-1	2008	Colon tumors expressing high levels of beta-catenin and c-myc have been reported in male F344 rats given three short cycles of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) alternating with a high-fat (HF) diet.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	127-174	catenin beta 1	Rattus norvegicus	39-51
18616682-1	2008	Colon tumors expressing high levels of beta-catenin and c-myc have been reported in male F344 rats given three short cycles of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) alternating with a high-fat (HF) diet.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	176-180	catenin beta 1	Rattus norvegicus	39-51
18616682-7	2008	Thus, during the early stages of colon carcinogenesis, alternating exposure to heterocyclic amines and a high-fat diet might facilitate molecular changes resulting in dysregulated beta-catenin and c-myc expression.	Amines	92-98	catenin beta 1	Rattus norvegicus	180-192
18541646-10	2008	Furthermore, treatment of cells with AG or UAG resulted in nuclear translocation of beta-catenin.	URIDINE-5'-DIPHOSPHATE-N-ACETYLMURAMOYL-L-ALANINE-D-GLUTAMATE	43-46	catenin beta 1	Rattus norvegicus	84-96
18467435-4	2008	Muscle atrophy induced by dexamethasone (dexa) administration occurred with a decrease in Akt (-53%; P&lt;0.01) phosphorylation together with a decrease in beta-catenin protein levels (-40%; P&lt;0.001).	Dexamethasone	26-39	catenin beta 1	Rattus norvegicus	156-168
18339714-2	2008	Although reactive oxygen radicals and Wnt signaling components are potent regulators that modulate renal tissue remodeling and morphogenesis, cross-talk between oxidative stress and Wnt/beta-catenin signaling in controlling high-glucose-impaired mesangial cell survival and renal function have not been tested.	Glucose	229-236	catenin beta 1	Rattus norvegicus	186-198
18445133-0	2008	Concomitant degradation of beta-catenin and GSK-3 beta potently contributes to glutamate-induced neurotoxicity in rat hippocampal slice cultures.	Glutamic Acid	79-88	catenin beta 1	Rattus norvegicus	27-39
18445133-5	2008	Notably, glutamate-induced calpain-1 activation decreased the level of beta-catenin, and this process appeared to be independent of glycogen synthase kinase 3beta (GSK-3beta), since glutamate also led to loss of GSK-3beta.	Glutamic Acid	9-18	catenin beta 1	Rattus norvegicus	71-83
18467435-9	2008	Furthermore, overexpression of a dominant-negative GSK-3beta or a stable form of beta-catenin increased fiber cross-sectional area by, respectively, 23% (P&lt;0.001) and 29% (P&lt;0.001) in dexa-treated rats, preventing completely the atrophic effect of GC.	Dexamethasone	190-194	catenin beta 1	Rattus norvegicus	81-93
18445133-6	2008	Calpeptin, a calpain inhibitor, attenuated the glutamate-mediated degradations of spectrin, synaptophysin, and beta-catenin except GSK-3beta and modestly increased cell survival.	Glutamic Acid	47-56	catenin beta 1	Rattus norvegicus	111-123
18445133-7	2008	In contrast, the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (APV) effectively reduced all glutamate-evoked responses, i.e., the breakdowns of spectrin, synaptophysin, beta-catenin and GSK-3beta, and cell death.	2-Amino-5-phosphonovalerate	42-75	catenin beta 1	Rattus norvegicus	183-195
18445133-7	2008	In contrast, the NMDA receptor antagonist 2-amino-5-phosphonopentanoic acid (APV) effectively reduced all glutamate-evoked responses, i.e., the breakdowns of spectrin, synaptophysin, beta-catenin and GSK-3beta, and cell death.	apv	77-80	catenin beta 1	Rattus norvegicus	183-195
18445133-8	2008	Pharmacological studies and in vitro calpain-1 proteolysis confirmed that in the glutamate-treated hippocampus, calpain-1-mediated decrease of beta-catenin could occur independently of GSK-3beta and of proteasome, and that GSK-3beta degradation is independent of calpain-1.	Glutamic Acid	81-90	catenin beta 1	Rattus norvegicus	143-155
18445133-9	2008	These findings together provide the first direct evidence that glutamate promotes the down-regulations of beta-catenin and GSK-3beta, which potently contribute to neurotoxicity in hippocampus during excitotoxic cell death, and a molecular basis for the protection afforded by calpeptin and APV from the neurotoxic effect of glutamate.	Glutamic Acid	63-72	catenin beta 1	Rattus norvegicus	106-118
18445133-9	2008	These findings together provide the first direct evidence that glutamate promotes the down-regulations of beta-catenin and GSK-3beta, which potently contribute to neurotoxicity in hippocampus during excitotoxic cell death, and a molecular basis for the protection afforded by calpeptin and APV from the neurotoxic effect of glutamate.	Glutamic Acid	324-333	catenin beta 1	Rattus norvegicus	106-118
18656628-6	2008	RESULTS: After treatment of hemorrhaged animals with VPA, acetylated beta-catenin was found in both the cytosol and nucleus, along with Ac-H3K9.	Valproic Acid	53-56	catenin beta 1	Rattus norvegicus	69-81
18656628-8	2008	Confocal imaging demonstrated that after VPA treatment, beta-catenin translocated into the nucleus and colocalized with Ac-H3K9.	Valproic Acid	41-44	catenin beta 1	Rattus norvegicus	56-68
18656628-9	2008	CONCLUSION: VPA treatment acetylates H3K9 and beta-catenin and enhances translocation of beta-catenin into the nucleus, where it colocalizes with Ac-H3K9 and stimulates the transcription of survival gene bcl-2.	Valproic Acid	12-15	catenin beta 1	Rattus norvegicus	46-58
18656628-9	2008	CONCLUSION: VPA treatment acetylates H3K9 and beta-catenin and enhances translocation of beta-catenin into the nucleus, where it colocalizes with Ac-H3K9 and stimulates the transcription of survival gene bcl-2.	Valproic Acid	12-15	catenin beta 1	Rattus norvegicus	89-101
18511088-7	2008	These results suggest that the hippocampal proliferative effect of chronic venlafaxine, only evident when both serotonin (5-HT) and noradrenaline/norepinephrine (NE) reuptake systems are inhibited, requires a strong activation of intracellular signaling through Wnt (beta-catenin translocation) and AKT/PKB pathways.	Venlafaxine Hydrochloride	75-86	catenin beta 1	Rattus norvegicus	267-279
18339714-0	2008	Superoxide destabilization of beta-catenin augments apoptosis of high-glucose-stressed mesangial cells.	Superoxides	0-10	catenin beta 1	Rattus norvegicus	30-42
18339714-0	2008	Superoxide destabilization of beta-catenin augments apoptosis of high-glucose-stressed mesangial cells.	Glucose	70-77	catenin beta 1	Rattus norvegicus	30-42
18339714-3	2008	In this study, high glucose induced Ras and Rac1 activation, superoxide burst, and Wnt5a/beta-catenin destabilization and subsequently promoted caspase-3 and poly (ADP-ribose) polymerase cleavage and apoptosis in mesangial cell cultures.	Glucose	20-27	catenin beta 1	Rattus norvegicus	89-101
18339714-6	2008	Stabilization of beta-catenin by the transfection of stable beta-catenin (Delta45) and kinase-inactive GSK-3beta attenuated high-glucose-mediated mesangial cell apoptosis.	Glucose	129-136	catenin beta 1	Rattus norvegicus	17-29
18339714-10	2008	The Ras and Rac1 regulation of superoxide appeared to raise apoptotic activity by activating GSK-3beta and inhibiting Wnt5a/beta-catenin signaling.	Superoxides	31-41	catenin beta 1	Rattus norvegicus	124-136
18339714-11	2008	Controlling oxidative stress and Wnt/beta-catenin signaling has potential for protecting renal tissue against the deleterious effect of high glucose.	Glucose	141-148	catenin beta 1	Rattus norvegicus	37-49
18387957-9	2008	We further demonstrated that oxidative stress induced by hydrogen peroxide (H2O2) dephosphorylates Akt and GSK-3beta, increases GSK-3beta activity, and promotes an interaction with beta-catenin and its degradation.	Hydrogen Peroxide	76-80	catenin beta 1	Rattus norvegicus	181-193
18343578-3	2008	We found that inactivation of beta-catenin by siRNA caused the decline of beta-catenin in the ischemic striatum, enlarged stroke-induced infarct volume, reduced SVZ expansion, and inhibited striatal neurogenesis in adult rat brain following a transient middle cerebral artery occlusion (tMCAO).	tmcao	287-292	catenin beta 1	Rattus norvegicus	30-42
18387957-9	2008	We further demonstrated that oxidative stress induced by hydrogen peroxide (H2O2) dephosphorylates Akt and GSK-3beta, increases GSK-3beta activity, and promotes an interaction with beta-catenin and its degradation.	Hydrogen Peroxide	57-74	catenin beta 1	Rattus norvegicus	181-193
18463494-5	2008	The caspase 3-specific inhibitor, Z-DQMD-FMK, attenuated beta-catenin degradation, but it did not affect phosphorylation of both beta-catenin and glycogen synthase kinase-3beta.	Z-D(OMe)QMD(OMe)-fmk	34-44	catenin beta 1	Rattus norvegicus	57-69
18296634-8	2008	Lithium treatment increased the intracellular accumulation of beta-catenin in association with increased levels of phosphorylated glycogen synthase kinase type 3beta (GSK3beta).	Lithium	0-7	catenin beta 1	Rattus norvegicus	62-74
18283038-6	2008	In the colon tumors, beta-catenin mutations were detected at a higher frequency after caffeine posttreatment, and there was a shift toward more tumors harboring substitutions of Gly34 with correspondingly high protein and messenger RNA expression seen for both beta-catenin and c-Myc.	Caffeine	86-94	catenin beta 1	Rattus norvegicus	21-33
19099732-17	2008	Antenatal DEX usage can change the expressions of Wnt7b, GSK-3beta and beta-catenin genes mRNA and protein, these changes may result in paramorphia during pregnancy.	Dexamethasone	10-13	catenin beta 1	Rattus norvegicus	71-83
17136310-0	2007	Cadmium induces nuclear translocation of beta-catenin and increases expression of c-myc and Abcb1a in kidney proximal tubule cells.	Cadmium	0-7	catenin beta 1	Rattus norvegicus	41-53
18347142-6	2008	(-)-Agelastatin A treatment also reduced beta-catenin protein expression and reduced anchorage-independent growth, adhesion, and invasion in R37 OPN pBK-CMV and C9 cell lines.	agelastatin A	0-17	catenin beta 1	Rattus norvegicus	41-53
18004065-2	2008	We examined the role of simvastatin (SIM) in modulation of Wnt/beta-catenin signaling in the apoptosis of high glucose (HG)-stressed mesangial cells in vitro and in vivo.	Simvastatin	24-35	catenin beta 1	Rattus norvegicus	63-75
17988238-9	2008	In addition, expression of a constitutively active mutant of beta-catenin potently activated the canonical Wnt pathway and reduced [3H]thymidine incorporation.	Tritium	132-134	catenin beta 1	Rattus norvegicus	61-73
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	77-84	catenin beta 1	Rattus norvegicus	244-256
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	77-84	catenin beta 1	Rattus norvegicus	384-396
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	107-114	catenin beta 1	Rattus norvegicus	244-256
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	107-114	catenin beta 1	Rattus norvegicus	384-396
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	107-114	catenin beta 1	Rattus norvegicus	244-256
17980489-7	2007	Confirming the involvement of a known regulatory pathway in these actions of lithium, we demonstrated that lithium co-administration prevented the stress-induced upregulation of glycogen synthase kinase-3beta (GSK-3beta) and down-regulation of beta-catenin expression; GSK-3beta is a known primary lithium target and its inhibition by this mood stabilizer leads to an upregulation of beta-catenin and subsequently, an increase of VEGF.	Lithium	107-114	catenin beta 1	Rattus norvegicus	384-396
17136310-1	2007	Cadmium (Cd2+) induces renal proximal tubular (PT) damage, including disruption of the E-cadherin/beta-catenin complex of adherens junctions (AJs) and apoptosis.	Cadmium	0-7	catenin beta 1	Rattus norvegicus	98-110
17963611-0	2007	[Changes of beta catenin in carcinogenesis in rat livers induced by aflatoxin B1].	Aflatoxin B1	68-80	catenin beta 1	Rattus norvegicus	12-24
17510083-10	2007	These findings indicate that inflammation-associated regenerative mucosa with Paneth cell metaplasia and alteration in the APC/beta-catenin/Tcf signal transduction pathway are possibly involved in the acceleration of colorectal carcinogenesis in this DMH-DSS rat model.	1,2-Dimethylhydrazine	251-254	catenin beta 1	Rattus norvegicus	127-139
17510083-10	2007	These findings indicate that inflammation-associated regenerative mucosa with Paneth cell metaplasia and alteration in the APC/beta-catenin/Tcf signal transduction pathway are possibly involved in the acceleration of colorectal carcinogenesis in this DMH-DSS rat model.	dss	255-258	catenin beta 1	Rattus norvegicus	127-139
17639448-0	2007	Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats.	diisopropanolnitrosamine	154-188	catenin beta 1	Rattus norvegicus	44-56
17404573-2	2007	Similarly, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat have increased beta-catenin and elevated Bcl-2.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	11-58	catenin beta 1	Rattus norvegicus	113-125
17404573-2	2007	Similarly, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-induced colon tumors in the rat have increased beta-catenin and elevated Bcl-2.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	60-64	catenin beta 1	Rattus norvegicus	113-125
17595165-0	2007	Inositol pentakisphosphate mediates Wnt/beta-catenin signaling.	inositol pentaphosphate	0-26	catenin beta 1	Rattus norvegicus	40-52
17639448-1	2007	In this study we investigated the Ser33 phosphorylation status of beta-catenin protein in relation to genomic mutations in lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in male Fischer 344 rats.	diisopropanolnitrosamine	163-197	catenin beta 1	Rattus norvegicus	66-78
17639448-1	2007	In this study we investigated the Ser33 phosphorylation status of beta-catenin protein in relation to genomic mutations in lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in male Fischer 344 rats.	bhp	199-202	catenin beta 1	Rattus norvegicus	66-78
17341692-7	2007	Wnt pathway inhibition by Gen was supported by reduced cyclin D1 immunoreactivity in mammary ductal epithelium of Gen relative to Cas and SPI groups, despite comparable levels of membrane-localized E-cadherin and beta-catenin.	Genistein	26-29	catenin beta 1	Rattus norvegicus	213-225
17472703-4	2007	Western blotting (WB) revealed that treatment with haloperidol or clozapine caused an up-regulation of Wnt-5a, dishevelled-3, Axin, total and phosphorylated GSK-3 and beta-catenin protein levels.	Haloperidol	51-62	catenin beta 1	Rattus norvegicus	167-179
17472703-4	2007	Western blotting (WB) revealed that treatment with haloperidol or clozapine caused an up-regulation of Wnt-5a, dishevelled-3, Axin, total and phosphorylated GSK-3 and beta-catenin protein levels.	Clozapine	66-75	catenin beta 1	Rattus norvegicus	167-179
17360687-7	2007	Reduced levels of beta-catenin antagonized the antiapoptotic effect of tau, whereas overexpressing beta-catenin conferred resistance to apoptosis.	uridine triacetate	71-74	catenin beta 1	Rattus norvegicus	18-30
17368581-3	2007	Furthermore, cell-cell contacts between RIE1-Sca cells were reformed by treatment with a specific MEK inhibitor (U0126), with translocation of ZO1 and beta-catenin to cell-cell contacts, without changes of their expression levels.	U 0126	113-118	catenin beta 1	Rattus norvegicus	151-163
17194898-0	2007	Long-term feeding of various fat diets modulates azoxymethane-induced colon carcinogenesis through Wnt/beta-catenin signaling in rats.	Azoxymethane	49-61	catenin beta 1	Rattus norvegicus	103-115
17400807-10	2007	In addition, these final results suggest that TSH-induced increase in Wnt-1 levels in thyrocytes contributes to enhanced cellular growth via a PKC pathway that increases STAT3 serine phosphorylation and activation, whereas TSH-induced decrease in activation of beta-catenin simultaneously relieves transcriptional suppression of TPO.	Thyrotropin	46-49	catenin beta 1	Rattus norvegicus	261-273
17400807-10	2007	In addition, these final results suggest that TSH-induced increase in Wnt-1 levels in thyrocytes contributes to enhanced cellular growth via a PKC pathway that increases STAT3 serine phosphorylation and activation, whereas TSH-induced decrease in activation of beta-catenin simultaneously relieves transcriptional suppression of TPO.	Thyrotropin	223-226	catenin beta 1	Rattus norvegicus	261-273
17400807-6	2007	beta-Catenin overexpression significantly increased complex formation between beta-catenin/TCF-1 and an oligonucleotide containing the TCF/LEF sequence, suggesting that the beta-catenin/TCF-1 complex acts as a transcriptional repressor of the TPO gene.	Oligonucleotides	104-119	catenin beta 1	Rattus norvegicus	0-12
17400807-6	2007	beta-Catenin overexpression significantly increased complex formation between beta-catenin/TCF-1 and an oligonucleotide containing the TCF/LEF sequence, suggesting that the beta-catenin/TCF-1 complex acts as a transcriptional repressor of the TPO gene.	Oligonucleotides	104-119	catenin beta 1	Rattus norvegicus	78-90
17400807-6	2007	beta-Catenin overexpression significantly increased complex formation between beta-catenin/TCF-1 and an oligonucleotide containing the TCF/LEF sequence, suggesting that the beta-catenin/TCF-1 complex acts as a transcriptional repressor of the TPO gene.	Oligonucleotides	104-119	catenin beta 1	Rattus norvegicus	173-185
17360687-8	2007	These results reveal an antiapoptotic function of tau hyperphosphorylation, which likely inhibits competitively phosphorylation of beta-catenin by GSK-3beta and hence facilitates the function of beta-catenin.	uridine triacetate	50-53	catenin beta 1	Rattus norvegicus	131-143
17360687-8	2007	These results reveal an antiapoptotic function of tau hyperphosphorylation, which likely inhibits competitively phosphorylation of beta-catenin by GSK-3beta and hence facilitates the function of beta-catenin.	uridine triacetate	50-53	catenin beta 1	Rattus norvegicus	195-207
16952352-0	2006	Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions.	Tyrosine	0-8	catenin beta 1	Rattus norvegicus	33-45
17170212-7	2006	Translocation of beta-catenin from the cytosol to the nuclei in progesterone-pretreated stromal cells was stimulated in response to estradiol.	Progesterone	64-76	catenin beta 1	Rattus norvegicus	17-29
17170212-7	2006	Translocation of beta-catenin from the cytosol to the nuclei in progesterone-pretreated stromal cells was stimulated in response to estradiol.	Estradiol	132-141	catenin beta 1	Rattus norvegicus	17-29
17170212-8	2006	Beta-catenin binding to TCF/LEF increased (P&lt;0.05) in progesterone-pretreated uteri in response to estradiol.	Progesterone	57-69	catenin beta 1	Rattus norvegicus	0-12
17170212-8	2006	Beta-catenin binding to TCF/LEF increased (P&lt;0.05) in progesterone-pretreated uteri in response to estradiol.	Estradiol	102-111	catenin beta 1	Rattus norvegicus	0-12
17170212-12	2006	However, nuclear translocation of beta-catenin and sufficient complex formation with TCF/LEF to activate stromal cell cycle entry requires estradiol.	Estradiol	139-148	catenin beta 1	Rattus norvegicus	34-46
16952352-0	2006	Tyrosine residues 654 and 670 in beta-catenin are crucial in regulation of Met-beta-catenin interactions.	Tyrosine	0-8	catenin beta 1	Rattus norvegicus	79-91
16952352-1	2006	beta-Catenin, a key component of the canonical Wnt pathway, is also regulated by tyrosine phosphorylation that regulates its association to E-cadherin.	Tyrosine	81-89	catenin beta 1	Rattus norvegicus	0-12
16952352-3	2006	HGF induced Met-beta-catenin dissociation and nuclear translocation of beta-catenin, which was tyrosine-phosphorylation-dependent.	Tyrosine	95-103	catenin beta 1	Rattus norvegicus	16-28
16952352-3	2006	HGF induced Met-beta-catenin dissociation and nuclear translocation of beta-catenin, which was tyrosine-phosphorylation-dependent.	Tyrosine	95-103	catenin beta 1	Rattus norvegicus	71-83
16952352-8	2006	Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis.	Tyrosine	25-33	catenin beta 1	Rattus norvegicus	46-58
16952352-8	2006	Thus, intact 654 and 670 tyrosine residues in beta-catenin are crucial in HGF-mediated beta-catenin translocation, activation and mitogenesis.	Tyrosine	25-33	catenin beta 1	Rattus norvegicus	87-99
16920707-4	2006	Adenovirus-mediated gene transfer of nonphosphorylatable constitutively active beta-catenin (Ad-catenin) decreased apoptosis in cardiomyocytes and cardiac fibroblasts with increased expression of survivin and Bcl-2.	ad-catenin	93-103	catenin beta 1	Rattus norvegicus	79-91
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	1,2-Dimethylhydrazine	23-44	catenin beta 1	Rattus norvegicus	120-132
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	1,2-Dimethylhydrazine	23-44	catenin beta 1	Rattus norvegicus	157-169
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	chlorophyllin	50-63	catenin beta 1	Rattus norvegicus	120-132
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	chlorophyllin	50-63	catenin beta 1	Rattus norvegicus	157-169
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	indole-3-carbinol	67-84	catenin beta 1	Rattus norvegicus	120-132
16860348-0	2006	Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.	indole-3-carbinol	67-84	catenin beta 1	Rattus norvegicus	157-169
16860348-1	2006	Tumors induced in the rat by 1,2-dimethylhydrazine (DMH) contain mutations in beta-catenin, but the spectrum of such mutations can be influenced by phytochemicals such as chlorophyllin (CHL) and indole-3-carbinol (I3C).	1,2-Dimethylhydrazine	29-50	catenin beta 1	Rattus norvegicus	78-90
16860348-1	2006	Tumors induced in the rat by 1,2-dimethylhydrazine (DMH) contain mutations in beta-catenin, but the spectrum of such mutations can be influenced by phytochemicals such as chlorophyllin (CHL) and indole-3-carbinol (I3C).	1,2-Dimethylhydrazine	52-55	catenin beta 1	Rattus norvegicus	78-90
16860348-2	2006	In the present study, we determined the mutation status of beta-catenin in more than 50 DMH-induced colon tumors and small intestine tumors, and compared this with the concomitant expression of beta-catenin mRNA using quantitative real-time RT-PCR analysis.	1,2-Dimethylhydrazine	88-91	catenin beta 1	Rattus norvegicus	59-71
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	49-61
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	165-177
16860348-7	2006	We conclude that DMH-induced mutations stabilize beta-catenin protein in tumors, which increase c-myc, c-jun and cyclin D1, but there also can be over-expression of beta-catenin itself at the mRNA level, contributing to high beta-catenin protein levels.	1,2-Dimethylhydrazine	17-20	catenin beta 1	Rattus norvegicus	165-177
16943306-4	2006	High glucose downregulated Wnt4 and Wnt5a expression and the subsequent nuclear translocation of beta-catenin, whereas it increased glycogen synthase kinase-3beta (GSK-3beta) and caspase-3 activities and apoptosis of glomerular mesangial cells.	Glucose	5-12	catenin beta 1	Rattus norvegicus	97-109
16943306-0	2006	Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells.	Glucose	54-61	catenin beta 1	Rattus norvegicus	4-16
16943306-5	2006	Suppression of GSK-3beta activation or increase in nuclear beta-catenin by transfection of Wnt4 or Wnt5a or stable beta-catenin (S33Y) reversed Akt activation and reduced the high glucose-mediated caspase-3 cleavage and cell apoptosis.	Glucose	180-187	catenin beta 1	Rattus norvegicus	59-71
16943306-2	2006	Whereas Wnt signaling has been found to regulate renal morphogenesis and pathogenesis, the biologic role of Wnt/beta-catenin signaling in controlling high glucose-induced mesangial cell apoptosis is not well defined.	Glucose	155-162	catenin beta 1	Rattus norvegicus	112-124
16943306-5	2006	Suppression of GSK-3beta activation or increase in nuclear beta-catenin by transfection of Wnt4 or Wnt5a or stable beta-catenin (S33Y) reversed Akt activation and reduced the high glucose-mediated caspase-3 cleavage and cell apoptosis.	Glucose	180-187	catenin beta 1	Rattus norvegicus	115-127
16943306-3	2006	Herein is reported that Wnt/beta-catenin signaling is required for protecting glomerular mesangial cells from high glucose-mediated cell apoptosis.	Glucose	115-122	catenin beta 1	Rattus norvegicus	28-40
16943306-6	2006	Pharmacologic inhibition of GSK-3beta by recombinant Wnt5a or bromoindirubin-3"-oxime or LiCl increased Akt phosphorylation and beta-catenin translocation and abrogated high glucose-mediated proapoptotic activities.	bromoindirubin-3"-oxime	62-85	catenin beta 1	Rattus norvegicus	128-140
16943306-6	2006	Pharmacologic inhibition of GSK-3beta by recombinant Wnt5a or bromoindirubin-3"-oxime or LiCl increased Akt phosphorylation and beta-catenin translocation and abrogated high glucose-mediated proapoptotic activities.	Lithium Chloride	89-93	catenin beta 1	Rattus norvegicus	128-140
16943306-7	2006	Exogenous bromoindirubin-3"-oxime treatment reduced phospho-Ser(9)-GSK-3beta and beta-catenin expression and apoptosis of cells adjacent to glomeruli in diabetic kidneys and attenuated urinary protein secretion in diabetic rats.	bromoindirubin-3"-oxime	10-33	catenin beta 1	Rattus norvegicus	81-93
16580782-7	2006	Treatment of neurospheres with DETA-NONOate significantly decreased neurosphere formation and telomerase activity, and promoted neuronal differentiation and neurite outgrowth concomitantly with increased N-cadherin and beta-catenin mRNA expression in both young and old neurospheres.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	31-43	catenin beta 1	Rattus norvegicus	219-231
16940239-3	2006	Bumetanide, which inhibits fluid distension, blocked down-regulation of the Shh/Wnt/betacatenin pathway and up-regulation of the PTHrP pathway, whereas PTHrP (1-34, 5 x 10(-7) M) treatment overcame bumetanide inhibition, and the PTHrP receptor antagonist PTHrP (7-34) amide (5 x 10(-6) M) mimicked bumetanide, indicating that PTHrP signaling mediates fluid distension-induced alveolar differentiation.	Bumetanide	0-10	catenin beta 1	Rattus norvegicus	84-95
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	Lithium Chloride	26-30	catenin beta 1	Rattus norvegicus	4-15
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	Lithium Chloride	26-30	catenin beta 1	Rattus norvegicus	63-74
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	Lithium Chloride	26-30	catenin beta 1	Rattus norvegicus	63-74
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	sb415268	34-42	catenin beta 1	Rattus norvegicus	4-15
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	sb415268	34-42	catenin beta 1	Rattus norvegicus	63-74
16940239-5	2006	Wnt/betacatenin agonists (LiCl or SB415268) maintained Shh/Wnt/betacatenin signaling, blocking spontaneous up-regulation of the PTHrP pathway, whereas PTHrP or cAMP down-regulated Shh/Wnt/betacatenin signaling and stimulated PTHrP signaling for fibroblast and type II cell differentiation.	sb415268	34-42	catenin beta 1	Rattus norvegicus	63-74
16928827-0	2006	Chemoprevention of colon carcinogenesis by polyethylene glycol: suppression of epithelial proliferation via modulation of SNAIL/beta-catenin signaling.	Polyethylene Glycols	43-62	catenin beta 1	Rattus norvegicus	128-140
16928827-2	2006	In this study, we assessed the ability of PEG to target cyclin D1-beta-catenin-mediated hyperproliferation in the azoxymethane-treated rat model and the human colorectal cancer cell line, HT-29.	Polyethylene Glycols	42-45	catenin beta 1	Rattus norvegicus	66-78
16928827-2	2006	In this study, we assessed the ability of PEG to target cyclin D1-beta-catenin-mediated hyperproliferation in the azoxymethane-treated rat model and the human colorectal cancer cell line, HT-29.	Azoxymethane	114-126	catenin beta 1	Rattus norvegicus	66-78
16928827-7	2006	Because beta-catenin is the major regulator of cyclin D1 in colorectal cancer, we used the T-cell factor (Tcf)-TOPFLASH reporter assay to show that PEG markedly inhibited beta-catenin transcriptional activity.	Polyethylene Glycols	148-151	catenin beta 1	Rattus norvegicus	8-20
16928827-7	2006	Because beta-catenin is the major regulator of cyclin D1 in colorectal cancer, we used the T-cell factor (Tcf)-TOPFLASH reporter assay to show that PEG markedly inhibited beta-catenin transcriptional activity.	Polyethylene Glycols	148-151	catenin beta 1	Rattus norvegicus	171-183
16810007-7	2006	In addition, they demonstrated that beta-catenin, a transcription factor downstream of Akt, was induced during morphine withdrawal, particularly during recurrent withdrawal.	Morphine	111-119	catenin beta 1	Rattus norvegicus	36-48
16886601-2	2006	The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS).	Azoxymethane	181-193	catenin beta 1	Rattus norvegicus	132-144
16886601-2	2006	The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS).	Azoxymethane	195-198	catenin beta 1	Rattus norvegicus	132-144
16886601-2	2006	The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS).	Dextran Sulfate	205-227	catenin beta 1	Rattus norvegicus	132-144
16886601-2	2006	The purpose of this study was to investigate the association between the mRNA expression level of the Mgmt gene and mutation of the beta-catenin gene in rat colon tumors induced by azoxymethane (AOM) plus dextran sulfate sodium (DSS).	Dextran Sulfate	229-232	catenin beta 1	Rattus norvegicus	132-144
16478782-6	2006	beta-Catenin dephosphorylation was intensity dependent, as dephosphorylation was highly correlated with muscle glycogen depletion during exercise (r(2) = 0.84, P &lt; 0.001).	Glycogen	111-119	catenin beta 1	Rattus norvegicus	0-12
16478782-7	2006	beta-Catenin dephosphorylation was accompanied by increases in GSK-3beta Ser(9) phosphorylation and Dvl-GSK-3beta association.	Serine	73-76	catenin beta 1	Rattus norvegicus	0-12
16580782-10	2006	Anti-N-cadherin reversed DETA-NONOate-induced neurosphere adhesion, neuronal differentiation, neurite outgrowth, and beta-catenin mRNA expression.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	25-37	catenin beta 1	Rattus norvegicus	117-129
16580782-14	2006	The molecular mechanisms associated with the DETA-NONOate modulation of neurospheres from young and older animals as well age dependent effects of neurospheres appear to be controlled by N-cadherin and beta-catenin gene expression, which subsequently regulates the neuronal differentiating factor Neurogenin expression in both young and old neural progenitor cells.	2,2'-(hydroxynitrosohydrazono)bis-ethanamine	45-57	catenin beta 1	Rattus norvegicus	202-214
16551644-0	2006	Differential expression patterns of Wnt and beta-catenin/TCF target genes in the uterus of immature female rats exposed to 17alpha-ethynyl estradiol.	Ethinyl Estradiol	123-148	catenin beta 1	Rattus norvegicus	44-56
16671876-8	2006	By contrast, significantly stronger beta-catenin and Cyclin D1 mRNA expressions and protein levels were found in CsA-treated rats than controls by RT-PCR and immunohistochemistry at week 4, whereas PCNA production was stronger at both times.	Cyclosporine	113-116	catenin beta 1	Rattus norvegicus	36-48
16469439-6	2006	This SDF1alpha-induced beta-catenin stabilization effect was inhibited by pretreatment of the cells with either pertussis toxin (PTX), an inactivator of G protein-coupled receptors, or PD98059, a MEK1 inhibitor.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	185-192	catenin beta 1	Rattus norvegicus	23-35
16469439-8	2006	Furthermore, SDF1alpha increased expression of genes such as Ccnd1, 2, 3, and c-Myc known as targets of the Wnt/beta-catenin/TCF pathway.	tcf	125-128	catenin beta 1	Rattus norvegicus	112-124
16671876-9	2006	CONCLUSIONS: CsA treatment reduced the production of E-cadherin but increased the production of beta-catenin, Cyclin D1, and PCNA.	Cyclosporine	13-16	catenin beta 1	Rattus norvegicus	96-108
16452189-4	2006	We used oligonucleotide microarrays to identify genes of which expression was activated in OEAs with beta-catenin dysregulation compared with OEAs lacking Wnt/beta-catenin pathway defects.	oeas	91-95	catenin beta 1	Rattus norvegicus	101-113
16389547-0	2006	The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells.	Cannabidiol	24-35	catenin beta 1	Rattus norvegicus	111-123
16389547-9	2006	The effect of cannabidiol is mediated through the Wnt/beta-catenin pathway rescue in Abeta-stimulated PC12 cells.	Cannabidiol	14-25	catenin beta 1	Rattus norvegicus	54-66
16761624-0	2006	Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.	1,2-Dimethylhydrazine	113-134	catenin beta 1	Rattus norvegicus	54-66
16761624-0	2006	Distribution of preneoplastic lesions and tumors, and beta-catenin gene mutations in colon carcinomas induced by 1,2-dimethylhydrazine plus dextran sulfate sodium.	Dextran Sulfate	140-162	catenin beta 1	Rattus norvegicus	54-66
16452189-9	2006	Our findings support the notion that FGF9 is a key factor contributing to the cancer phenotype of OEAs carrying Wnt/beta-catenin pathway defects.	oeas	98-102	catenin beta 1	Rattus norvegicus	116-128
16471326-11	2005	Production of Bax, pJNK, TGF-beta, TGFBRI, TGFBRII, and beta-catenin were higher in IEC6 cells treated with DCA (100 microg/ml) than that in cells with no treatment.	Deoxycholic Acid	108-111	catenin beta 1	Rattus norvegicus	56-68
16160859-10	2006	This coexisted with decreased beta-catenin tyrosine phosphorylation.	Tyrosine	43-51	catenin beta 1	Rattus norvegicus	30-42
16288908-7	2006	Lithium- or SB216763- treated rats revealed accumulation of cytosolic and nuclear beta-catenin.	Lithium	0-7	catenin beta 1	Rattus norvegicus	82-94
16288908-7	2006	Lithium- or SB216763- treated rats revealed accumulation of cytosolic and nuclear beta-catenin.	SB 216763	12-20	catenin beta 1	Rattus norvegicus	82-94
16162845-9	2005	The inactivation of GSK3beta in HCB-treated female rats resulted in the nuclear translocation of beta-catenin, as demonstrated by both immunocytochemistry and flow cytometric analyses.	Hexachlorobenzene	32-35	catenin beta 1	Rattus norvegicus	97-109
15858215-12	2005	These results illustrate that the CDH2/CATNB-mediated adhesion function in the testis is regulated, at least in part, via the NOS/cGMP/PRKG/CATNB pathway.	Cyclic GMP	130-134	catenin beta 1	Rattus norvegicus	39-44
15856452-10	2005	Vitamin A also prevented HLD-induced alterations and the increase in levels of COX-2 and beta-catenin.	Vitamin A	0-9	catenin beta 1	Rattus norvegicus	89-101
16144542-2	2005	Recently, we reported that haloperidol, clozapine and risperidone alter glycogen synthase kinase-3 and beta-catenin protein expression and glycogen synthase kinase-3 phosphorylation levels in the rat prefrontal cortex and striatum.	Haloperidol	27-38	catenin beta 1	Rattus norvegicus	103-115
16144542-2	2005	Recently, we reported that haloperidol, clozapine and risperidone alter glycogen synthase kinase-3 and beta-catenin protein expression and glycogen synthase kinase-3 phosphorylation levels in the rat prefrontal cortex and striatum.	Clozapine	40-49	catenin beta 1	Rattus norvegicus	103-115
16144542-2	2005	Recently, we reported that haloperidol, clozapine and risperidone alter glycogen synthase kinase-3 and beta-catenin protein expression and glycogen synthase kinase-3 phosphorylation levels in the rat prefrontal cortex and striatum.	Risperidone	54-65	catenin beta 1	Rattus norvegicus	103-115
16144542-6	2005	Raclopride causes similar changes in beta-catenin and GSK-3 in the ventral midbrain, suggesting that D2 dopamine receptor antagonism mediated the changes observed following antipsychotic administration.	Raclopride	0-10	catenin beta 1	Rattus norvegicus	37-49
16144542-7	2005	In contrast, amphetamine, a drug capable of inducing psychotic episodes, had the opposite effect on beta-catenin and GSK-3 in the ventral midbrain.	Amphetamine	13-24	catenin beta 1	Rattus norvegicus	100-112
15946752-6	2005	Moreover, we found that beta-catenin cytoplasmic and nuclear levels were increased, suggesting a failure of its down-regulation by the APC-GSK-3beta system, in particular the GSK-3beta phosphorylation of ser-33/37 and thr-41 of beta-catenin.	Serine	204-207	catenin beta 1	Rattus norvegicus	24-36
15946752-6	2005	Moreover, we found that beta-catenin cytoplasmic and nuclear levels were increased, suggesting a failure of its down-regulation by the APC-GSK-3beta system, in particular the GSK-3beta phosphorylation of ser-33/37 and thr-41 of beta-catenin.	Threonine	218-221	catenin beta 1	Rattus norvegicus	24-36
16014628-4	2005	Here, we demonstrate that the inhibition of GSK3 by LiCl induced the nuclear translocation of beta-catenin in Chinese hamster ovary cells and rat cultured neurons, in which a decrease in tau phosphorylation was observed.	Lithium Chloride	52-56	catenin beta 1	Rattus norvegicus	94-106
16014628-6	2005	SB415286, another GSK3 inhibitor, induced the nuclear translocation of beta-catenin and slightly decreased Abeta production.	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	0-8	catenin beta 1	Rattus norvegicus	71-83
15858215-12	2005	These results illustrate that the CDH2/CATNB-mediated adhesion function in the testis is regulated, at least in part, via the NOS/cGMP/PRKG/CATNB pathway.	Cyclic GMP	130-134	catenin beta 1	Rattus norvegicus	140-145
16093313-8	2005	Selective inhibition of TCF/beta-catenin/cAMP-response element-binding protein (CREB)-binding protein (CBP)-mediated transcription, but not TCF/beta-catenin/p300, with the recently described small molecule antagonist ICG-001 corrects these defects in neuronal differentiation, highlighting the importance of Wnt/beta-catenin signaling in this process.	Cyclic AMP	41-45	catenin beta 1	Rattus norvegicus	28-40
15750591-5	2005	We propose that the cadherin-beta-catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP.	Tyrosine	189-197	catenin beta 1	Rattus norvegicus	29-41
16012713-0	2005	Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.	aurapten	60-69	catenin beta 1	Rattus norvegicus	15-27
16012713-0	2005	Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats.	Diethylnitrosamine	96-118	catenin beta 1	Rattus norvegicus	15-27
16012713-7	2005	Mutations in the beta-catenin gene were detected in 8 of 24 HCCs (33.3%) in the DEN alone group, 7 of 15 HCCs (46.7%) in the DEN + AUR (initiation feeding) group, and 0 of 8 HCCs (0%) in the DENright curved arrow AUR (post-initiation feeding) group.	Diethylnitrosamine	80-83	catenin beta 1	Rattus norvegicus	17-29
16012713-7	2005	Mutations in the beta-catenin gene were detected in 8 of 24 HCCs (33.3%) in the DEN alone group, 7 of 15 HCCs (46.7%) in the DEN + AUR (initiation feeding) group, and 0 of 8 HCCs (0%) in the DENright curved arrow AUR (post-initiation feeding) group.	Diethylnitrosamine	125-128	catenin beta 1	Rattus norvegicus	17-29
16053526-9	2005	In the first approach, treatment with LiCl, which is known to activate beta-catenin, caused a several fold increase in alkaline phosphatase activity.	Lithium Chloride	38-42	catenin beta 1	Rattus norvegicus	71-83
15893845-0	2005	Morpholino oligonucleotide-triggered beta-catenin knockdown compromises normal liver regeneration.	Morpholinos	0-26	catenin beta 1	Rattus norvegicus	37-49
15893845-5	2005	RESULTS: AS group exhibited a significant decrease in total beta-catenin at 24 h. A significant decrease in liver/body weight ratio was also observed in the AS group at 24 h and 7 days that was due to decreased proliferation.	Arsenic	9-11	catenin beta 1	Rattus norvegicus	60-72
15649708-3	2005	IBU-PO (0.01-1 microM) inhibits glycogen-synthase-kinase-3beta (GSK-3beta) and stabilizes cytoplasmic beta-catenin reverting the silencing of the Wnt pathway caused by Abeta-toxicity and GSK-3beta overexpression.	ibuprofen-N-octyl-pyridostigmine	0-6	catenin beta 1	Rattus norvegicus	102-114
15737669-5	2005	RESULTS: Significant increases in the levels of beta-catenin and glycogen synthase kinase-3 total protein were identified following administration of clozapine, haloperidol or risperidone.	Clozapine	150-159	catenin beta 1	Rattus norvegicus	48-60
15737669-5	2005	RESULTS: Significant increases in the levels of beta-catenin and glycogen synthase kinase-3 total protein were identified following administration of clozapine, haloperidol or risperidone.	Haloperidol	161-172	catenin beta 1	Rattus norvegicus	48-60
15737669-5	2005	RESULTS: Significant increases in the levels of beta-catenin and glycogen synthase kinase-3 total protein were identified following administration of clozapine, haloperidol or risperidone.	Risperidone	176-187	catenin beta 1	Rattus norvegicus	48-60
15591133-6	2005	Indeed, there was a loss of N-cadherin and beta-catenin association, accompanied by a surge in Tyr phosphorylation of beta-catenin, during germ cell loss from the epithelium.	Tyrosine	95-98	catenin beta 1	Rattus norvegicus	118-130
15352211-0	2004	A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of beta-catenin.	Tyrosine	89-97	catenin beta 1	Rattus norvegicus	117-129
15617833-3	2005	However, in the azoxymethane-treated rat, where beta-catenin is frequently rendered GSK-3beta-insensitive, nabumetone failed to alter beta-catenin levels but did decrease beta-catenin nuclear localization and transcriptional activity as gauged by cyclin D1.	Azoxymethane	16-28	catenin beta 1	Rattus norvegicus	48-60
15580706-2	2004	Progression of alachlor-induced olfactory tumors in rats is accompanied by cytoplasmic accumulation and nuclear localization of beta-catenin, suggesting activation of Wint signaling.	alachlor	15-23	catenin beta 1	Rattus norvegicus	128-140
15546251-9	2004	Moreover, treatment of rats with 0.05% crude alpha-mangostin significantly decreased dysplastic foci (DF) (P&lt;0.05) and beta-catenin accumulated crypts (BCAC) (P&lt;0.05), to below the group 1 values.	mangostin	45-60	catenin beta 1	Rattus norvegicus	122-134
15352211-7	2004	Modification of cells by RsulfFP1 resulted in the increased tyrosine phosphorylation of immunoprecipitated beta-catenin, suggesting that sulfation of the extracellular matrix induced by this sulfatase might be responsible for an increase in Wnt signaling that is involved in the migration of OPCs.	Tyrosine	60-68	catenin beta 1	Rattus norvegicus	107-119
14551262-3	2004	Western blot and RT-PCR demonstrated that dexamethasone up-regulated beta-catenin protein and transcript expression and nearly ablated beta-catenin phosphorylation under conditions that led to a significant increase in monolayer transepithelial resistance.	Dexamethasone	42-55	catenin beta 1	Rattus norvegicus	69-81
15033165-0	2004	Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus.	Estradiol	0-9	catenin beta 1	Rattus norvegicus	83-95
15033165-9	2004	There is a second complex, also affected by estradiol, in which Tau is associated with GSK3, beta-catenin, and elements of the PI3 kinase complex.	Estradiol	44-53	catenin beta 1	Rattus norvegicus	93-105
15149841-0	2004	Wnt and beta-catenin signaling target the expression of ecto-5"-nucleotidase and increase extracellular adenosine generation.	Adenosine	104-113	catenin beta 1	Rattus norvegicus	8-20
14551262-3	2004	Western blot and RT-PCR demonstrated that dexamethasone up-regulated beta-catenin protein and transcript expression and nearly ablated beta-catenin phosphorylation under conditions that led to a significant increase in monolayer transepithelial resistance.	Dexamethasone	42-55	catenin beta 1	Rattus norvegicus	135-147
14551262-4	2004	Indirect immunofluorescence revealed that dexamethasone treatment also caused beta-catenin to localize predominantly at the cell membrane rather than the nucleus.	Dexamethasone	42-55	catenin beta 1	Rattus norvegicus	78-90
14551262-6	2004	The steroid induction of beta-catenin expression and localization can be uncoupled by altering the function of signaling pathways needed for tight junction formation.	Steroids	4-11	catenin beta 1	Rattus norvegicus	25-37
14551262-7	2004	Expression of dominant-negative RasN17 abolished dexamethasone up-regulation of beta-catenin protein expression without affecting its localization at the membrane.	Dexamethasone	49-62	catenin beta 1	Rattus norvegicus	80-92
14551262-8	2004	In contrast, exogenous treatment or constitutive production of TGFalpha abolished the dexamethasone-induced alteration of beta-catenin localization without affecting the dexamethasone stimulation of beta-catenin expression.	Dexamethasone	86-99	catenin beta 1	Rattus norvegicus	122-134
14635195-2	2003	In this report, we identify a novel ring zinc finger-leucine-rich repeat containing protein (RIFLE) and show that RIFLE, expressed in PC12 cells, enhances the Serine (Ser)21/9 phosphorylation of glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) resulting in the inhibition of GSK-3 kinase activity and increase of beta-catenin levels.	Serine	159-165	catenin beta 1	Rattus norvegicus	319-331
14713550-4	2004	A 1-month exposure to arsenic significantly increased hepatic mRNA levels of cyclin D1 (10 ppm), ILK (1 ppm), and p27(Kip1) (10 ppm), whereas it reduced mRNA levels of PTEN (1 ppm) and beta-catenin (100 ppm).	Arsenic	22-29	catenin beta 1	Rattus norvegicus	185-197
14713550-5	2004	In contrast, a 4-month arsenic exposure showed increased mRNA expression of cyclin D1 (100 ppm), ILK (1 ppm), and p27(Kip1) (1 and 10 ppm), and decreased expression of both PTEN and beta-catenin at all 3 doses.	Arsenic	23-30	catenin beta 1	Rattus norvegicus	182-194
14713550-7	2004	In conclusion, subchronic exposure to inorganic arsenate caused pathological changes and altered expression of cyclin D1, p27(Kip1), ILK, PTEN, and beta-catenin in the liver.	arsenic acid	48-56	catenin beta 1	Rattus norvegicus	148-160
14635195-2	2003	In this report, we identify a novel ring zinc finger-leucine-rich repeat containing protein (RIFLE) and show that RIFLE, expressed in PC12 cells, enhances the Serine (Ser)21/9 phosphorylation of glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) resulting in the inhibition of GSK-3 kinase activity and increase of beta-catenin levels.	Serine	159-162	catenin beta 1	Rattus norvegicus	319-331
12907644-2	2003	We established previously a stable clone of the rat small intestinal epithelial cell line IEC6, which is capable of inducing stabilized beta-catenin protein lacking NH(2)-terminal glycogen synthase kinase-3beta phosphorylation site under a strict control of the tetracycline-regulatory system.	Tetracycline	262-274	catenin beta 1	Rattus norvegicus	136-148
12800193-0	2003	Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin.	Butyrates	116-124	catenin beta 1	Rattus norvegicus	82-94
12800193-0	2003	Expression profiling of CC531 colon carcinoma cells reveals similar regulation of beta-catenin target genes by both butyrate and aspirin.	Aspirin	129-136	catenin beta 1	Rattus norvegicus	82-94
14528308-3	2003	We found that increasing the intracellular levels of beta-catenin and other members of the cadherin/catenin complex, namely N-cadherin and alphaN-catenin, enhances dendritic arborization in rat hippocampal neurons, an effect that does not require Wnt/beta-catenin-dependent transcription.	alphan-catenin	139-153	catenin beta 1	Rattus norvegicus	53-65
14641328-5	2003	As ectopic expression of beta-cateninS37A only partially mimics Wnt-1 effects on Rat-1 cells, we conclude that Wnt-1 signaling elicits biochemical events that act in addition to beta-catenin/Tcf signaling to promote cell growth.	tcf	191-194	catenin beta 1	Rattus norvegicus	25-37
14511119-7	2003	Further, compound SB216763 inhibited Tau phosphorylation at Ser396 and stabilized cytosolic beta-catenin, consistent with the inhibition of glycogen synthase kinase-3 beta (GSK-3 beta), but failed to reproduce lithium effects on MEK and ERK phosphorylation and cell cycle arrest.	SB 216763	18-26	catenin beta 1	Rattus norvegicus	92-104
12907644-3	2003	This clone, IEC6-TetOFF-beta-catenin DeltaN89, shows in vitro polypoid growth on the removal of doxycycline and seems to be an appropriate model for analyzing the molecular mechanisms of early intestinal carcinogenesis.	Doxycycline	96-107	catenin beta 1	Rattus norvegicus	24-36
12878481-0	2003	Myogenic signaling by lithium in cardiomyoblasts is Akt independent but requires activation of the beta-catenin-Tcf/Lef pathway.	Lithium	22-29	catenin beta 1	Rattus norvegicus	99-111
12700184-11	2003	Yet this AF-2364-induced Fer kinase plummeting associated with an induction in N-cadherin, beta-catenin, and p120ctn, particularly at the base of the seminiferous epithelium.	1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide	9-16	catenin beta 1	Rattus norvegicus	91-103
12878481-10	2003	We conclude that the capacity of lithium to overcome the inhibitory effects of serum and to induce the differentiation of H9c2 cardiomyoblasts is mediated, in part, by the stabilization and nuclear translocation of beta-catenin in a PI3-kinase-dependent but Akt-independent manner.	Lithium	33-40	catenin beta 1	Rattus norvegicus	215-227
12767522-6	2003	These results suggest that mutations in the beta-catenin gene are less contributory to the development of rat gastric carcinomas induced by MNU.	Methylnitrosourea	140-143	catenin beta 1	Rattus norvegicus	44-56
12747976-0	2003	Correlation of P-cadherin and beta-catenin expression and phosphorylation with carcinogenesis in rat tongue cancer induced with 4-nitroquinoline 1-oxide.	4-Nitroquinoline-1-oxide	128-152	catenin beta 1	Rattus norvegicus	30-42
12791303-0	2003	Cadmium alters the localization of N-cadherin, E-cadherin, and beta-catenin in the proximal tubule epithelium.	Cadmium	0-7	catenin beta 1	Rattus norvegicus	63-75
12669311-0	2003	Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational "hotspots" and the relative expression of beta-catenin and c-jun.	2-amino-3-methylimidazo(4,5-f)quinoline	89-128	catenin beta 1	Rattus norvegicus	23-29
12707019-6	2003	Immunoblot analyses demonstrated significantly less beta-catenin associated with the cytoskeletal subcellular fraction in thrombin-treated PKC alpha EC, an effect blocked by pretreatment with Go6976.	Go 6976	192-198	catenin beta 1	Rattus norvegicus	52-64
12606480-9	2003	beta1-Integrin and beta-catenin remained associated with spermatids after ES removal and until disengagement; however, ILK was removed along with the ES.	Einsteinium	74-76	catenin beta 1	Rattus norvegicus	19-31
12640114-0	2003	p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction.	Tyrosine	75-78	catenin beta 1	Rattus norvegicus	62-74
12640114-2	2003	We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142.	Tyrosine	117-120	catenin beta 1	Rattus norvegicus	33-45
12640114-2	2003	We show here that interaction of beta-catenin with alpha-catenin is regulated by the phosphorylation of beta-catenin Tyr-142.	Tyrosine	117-120	catenin beta 1	Rattus norvegicus	104-116
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	2-amino-3-methylimidazo(4,5-f)quinoline	26-65	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	2-amino-3-methylimidazo(4,5-f)quinoline	26-65	catenin beta 1	Rattus norvegicus	178-190
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	76-97	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	76-97	catenin beta 1	Rattus norvegicus	178-190
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	99-102	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	1,2-Dimethylhydrazine	99-102	catenin beta 1	Rattus norvegicus	178-190
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	chlorophyllin	263-276	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	chlorophyllin	278-281	catenin beta 1	Rattus norvegicus	157-163
12669311-2	2003	We recently reported that 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)- and 1,2-dimethylhydrazine (DMH)-induced colon tumors in the rat contain mutations in Ctnnb1, the gene for beta-catenin, but the mutation spectrum was influenced by postinitiation exposure to chlorophyllin (CHL) and indole-3-carbinol (I3C) [Blum et al., Carcinogenesis 2001;22:315-320].	indole-3-carbinol	287-304	catenin beta 1	Rattus norvegicus	157-163
12669311-4	2003	In tumors from rats given carcinogen alone, or carcinogen plus CHL or I3C, Ctnnb1 mutations frequently substituted amino acids adjacent to Ser33, a critical Ser/Thr residue in the glycogen synthase kinase-3beta regulatory domain of beta-catenin.	Serine	139-142	catenin beta 1	Rattus norvegicus	75-81
12669311-4	2003	In tumors from rats given carcinogen alone, or carcinogen plus CHL or I3C, Ctnnb1 mutations frequently substituted amino acids adjacent to Ser33, a critical Ser/Thr residue in the glycogen synthase kinase-3beta regulatory domain of beta-catenin.	Threonine	161-164	catenin beta 1	Rattus norvegicus	75-81
12577316-8	2003	Immunoprecipitation of Triton X-100 cardiomyocyte extracts using anti-beta-catenin antibodies showed that beta-catenin was associated with alpha-catenin, ZO-1, and Cx43 at 2 h after Ca(2+) switch.	Octoxynol	23-35	catenin beta 1	Rattus norvegicus	106-118
12628520-0	2003	Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.	chlorophyllin	60-73	catenin beta 1	Rattus norvegicus	140-152
12610652-4	2003	Lithium chloride, which mimics Wnt signaling by inhibiting glycogen synthase kinase-3beta promoted the survival of post-mitotic neurons against Abeta neurotoxicity and recovered cytosolic beta-catenin to control levels.	Lithium Chloride	0-16	catenin beta 1	Rattus norvegicus	188-200
12610652-6	2003	We also examined the spatial memory performance of rats injected with preformed Abeta fibrils in the Morris water maze paradigm, and found that chronic lithium treatment protected neurodegeneration by rescuing beta-catenin levels and improved the deficit in spatial learning induced by Abeta.	Lithium	152-159	catenin beta 1	Rattus norvegicus	210-222
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	2-amino-3-methylimidazo(4,5-f)quinoline	16-55	catenin beta 1	Rattus norvegicus	150-162
12628520-0	2003	Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.	Chlorophyll	60-71	catenin beta 1	Rattus norvegicus	140-152
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	1,2-Dimethylhydrazine	65-86	catenin beta 1	Rattus norvegicus	150-162
11929826-9	2002	This event is tyrosine phosphorylation dependent, and the association of Met and beta-catenin is crucial for this event.	Tyrosine	14-22	catenin beta 1	Rattus norvegicus	81-93
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	1,2-Dimethylhydrazine	88-91	catenin beta 1	Rattus norvegicus	150-162
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	Water	258-263	catenin beta 1	Rattus norvegicus	150-162
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	Chlorophyll	286-297	catenin beta 1	Rattus norvegicus	150-162
12628520-1	2003	The carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the mutation pattern can be influenced by exposure to dietary phytochemicals, such as the water-soluble derivative of chlorophyll called chlorophyllin.	chlorophyllin	305-318	catenin beta 1	Rattus norvegicus	150-162
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	chlorophyllin	95-108	catenin beta 1	Rattus norvegicus	46-58
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	Serine	194-197	catenin beta 1	Rattus norvegicus	46-58
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	Threonine	198-201	catenin beta 1	Rattus norvegicus	46-58
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	1,2-Dimethylhydrazine	312-315	catenin beta 1	Rattus norvegicus	46-58
12628520-5	2003	Molecular studies showed that the spectrum of beta-catenin mutations was markedly different in chlorophyllin-promoted colon tumors--many of the mutations led to direct substitutions of critical Ser/Thr residues within the glycogen synthase kinase-3beta (GSK-3beta) region, whereas in all other groups, including DMH and IQ controls, the mutations typically affected amino acids adjacent to Ser(33).	Serine	390-393	catenin beta 1	Rattus norvegicus	46-58
12628520-6	2003	Substitution of critical Ser/Thr residues caused beta-catenin and c-Jun proteins to be markedly over-expressed compared with tumors in which the mutations substituted amino acid residues flanking these critical Ser/Thr sites.	Serine	25-28	catenin beta 1	Rattus norvegicus	49-61
12628520-6	2003	Substitution of critical Ser/Thr residues caused beta-catenin and c-Jun proteins to be markedly over-expressed compared with tumors in which the mutations substituted amino acid residues flanking these critical Ser/Thr sites.	Threonine	29-32	catenin beta 1	Rattus norvegicus	49-61
12628520-6	2003	Substitution of critical Ser/Thr residues caused beta-catenin and c-Jun proteins to be markedly over-expressed compared with tumors in which the mutations substituted amino acid residues flanking these critical Ser/Thr sites.	Threonine	215-218	catenin beta 1	Rattus norvegicus	49-61
12421827-9	2003	Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines.	Colforsin	13-22	catenin beta 1	Rattus norvegicus	181-193
12421827-9	2003	Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines.	8-Bromo Cyclic Adenosine Monophosphate	27-36	catenin beta 1	Rattus norvegicus	181-193
12421827-9	2003	Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines.	Lithium	126-133	catenin beta 1	Rattus norvegicus	181-193
12421827-9	2003	Furthermore, forskolin and 8-Br-cAMP phosphorylated GSK-3beta at serine 9 in intestinal proglucagon-producing cells, and both lithium and forskolin induced the accumulation of free beta-catenin in these cell lines.	Colforsin	138-147	catenin beta 1	Rattus norvegicus	181-193
12570056-0	2002	Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide.	4-Nitroquinoline-1-oxide	71-95	catenin beta 1	Rattus norvegicus	14-26
12570338-7	2002	Expression of these beta-catenin-accumulated crypts (BCAC) is markedly suppressed by a chemopreventive cyclooxygenase-2 inhibitor, celecoxib.	bcac	53-57	catenin beta 1	Rattus norvegicus	20-32
12570338-7	2002	Expression of these beta-catenin-accumulated crypts (BCAC) is markedly suppressed by a chemopreventive cyclooxygenase-2 inhibitor, celecoxib.	Celecoxib	131-140	catenin beta 1	Rattus norvegicus	20-32
11795941-1	2002	In Con8 rat mammary epithelial tumor cells, the synthetic glucocorticoid dexamethasone stimulates transepithelial electrical resistance (TER), promotes the remodeling of apical junctions, and down-regulates the level of fascin, an actin-bundling protein that can bind to beta-catenin.	Dexamethasone	73-86	catenin beta 1	Rattus norvegicus	271-283
11746832-1	2001	Mutations in the region corresponding to the N-terminal phosphorylation sites (codons 1-51) of the rat beta-catenin gene (Ctnnb1) were investigated in rat colon tumors induced by 1-hydroxyanthraquinone (1-HA) plus methylazoxymethanol (MAM) acetate, by using polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) analysis.	1-hydroxyanthraquinone	179-201	catenin beta 1	Rattus norvegicus	103-115
11750994-1	2002	Lithium inhibits glycogen synthase kinase-3 (GSK-3), which leads to an increase of cytoplasmic beta-catenin levels.	Lithium	0-7	catenin beta 1	Rattus norvegicus	95-107
11343237-6	2001	We show this increase to be the result of decreased degradation of beta-catenin (decrease in serine phosphorylated beta-catenin) as seen by immunoprecipitation studies.	Serine	93-99	catenin beta 1	Rattus norvegicus	67-79
11696357-5	2001	By comparison, treatment with SB-216763 and SB-415286 proved more potent in terms of neuroprotection, and correlated with inhibition of GSK-3 activity towards GS in addition to Tau and beta-catenin.	SB 216763	30-39	catenin beta 1	Rattus norvegicus	185-197
11696357-5	2001	By comparison, treatment with SB-216763 and SB-415286 proved more potent in terms of neuroprotection, and correlated with inhibition of GSK-3 activity towards GS in addition to Tau and beta-catenin.	3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione	44-53	catenin beta 1	Rattus norvegicus	185-197
11429049-0	2001	Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib.	Celecoxib	166-175	catenin beta 1	Rattus norvegicus	45-57
11429049-3	2001	Here we investigated the effects of a selective cyclooxygenase-2 inhibitor, celecoxib, on the development of beta-catenin-accumulated crypts in comparison with those on ACF.	Celecoxib	76-85	catenin beta 1	Rattus norvegicus	109-121
11429049-5	2001	Groups 1 - 3 were administered azoxymethane (AOM) s.c. at a dose of 15 mg / kg body weight, once weekly for 3 weeks to induce beta-catenin-accumulated crypts.	Azoxymethane	31-43	catenin beta 1	Rattus norvegicus	126-138
11429049-5	2001	Groups 1 - 3 were administered azoxymethane (AOM) s.c. at a dose of 15 mg / kg body weight, once weekly for 3 weeks to induce beta-catenin-accumulated crypts.	Azoxymethane	45-48	catenin beta 1	Rattus norvegicus	126-138
11429049-8	2001	Furthermore, numbers of silver-stained nucleolar organizer regions (AgNORs) / nucleus in beta-catenin-accumulated crypts were also decreased by exposure to celecoxib.	Celecoxib	156-165	catenin beta 1	Rattus norvegicus	89-101
11429049-9	2001	In this study, celecoxib had greater effects on the frequency and growth of beta-catenin-accumulated crypts than on those of ACF.	Celecoxib	15-24	catenin beta 1	Rattus norvegicus	76-88
11429049-11	2001	The results also suggest that beta-catenin-accumulated crypts could be a novel target for evaluation of possible chemopreventive agents against colon carcino-genesis, and indicate that possible chemopreventive effects of celecoxib on the initial stage of colon carcinogenesis may be related to modulation of cell proliferation activity in such early lesions.	Celecoxib	221-230	catenin beta 1	Rattus norvegicus	30-42
11746832-2	2001	The beta-catenin gene was also screened for mutations in rat brain and oral tumors induced by ethyl nitrosourea (ENU) and 4-nitroquinoline 1-oxide (4-NQO), respectively.	Ethylnitrosourea	94-111	catenin beta 1	Rattus norvegicus	4-16
11746832-2	2001	The beta-catenin gene was also screened for mutations in rat brain and oral tumors induced by ethyl nitrosourea (ENU) and 4-nitroquinoline 1-oxide (4-NQO), respectively.	4-Nitroquinoline-1-oxide	122-146	catenin beta 1	Rattus norvegicus	4-16
11746832-2	2001	The beta-catenin gene was also screened for mutations in rat brain and oral tumors induced by ethyl nitrosourea (ENU) and 4-nitroquinoline 1-oxide (4-NQO), respectively.	4-Nitroquinoline-1-oxide	148-153	catenin beta 1	Rattus norvegicus	4-16
11698353-0	2001	Predominant mutation of codon 41 of the beta-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol.	1,2-Dimethylhydrazine	99-120	catenin beta 1	Rattus norvegicus	40-52
11698353-4	2001	Unlike previous studies, that have used relatively short-term (2-5 weeks) treatment with one of the alkylating agents 1,2,-dimethylhydrazine (DMH) or azoxymethane, we have investigated the mutational spectrum of the beta-catenin gene in a panel of rat colon tumors induced by long-term (20 weeks) DMH-treatment.	1,2-Dimethylhydrazine	118-140	catenin beta 1	Rattus norvegicus	216-228
11343237-6	2001	We show this increase to be the result of decreased degradation of beta-catenin (decrease in serine phosphorylated beta-catenin) as seen by immunoprecipitation studies.	Serine	93-99	catenin beta 1	Rattus norvegicus	115-127
11343237-7	2001	We observed activation of beta-catenin degradation complex comprising of adenomatous polyposis coli gene product (APC) and serine-phosphorylated axin protein, beginning at 5 minutes after hepatectomy, leading to its decreased levels after this time.	Serine	123-129	catenin beta 1	Rattus norvegicus	26-38
11343237-9	2001	In addition, using immunoprecipitation, we observe elevated levels of tyrosine-phosphorylated beta-catenin at 6 hours onward.	Tyrosine	70-78	catenin beta 1	Rattus norvegicus	94-106
11289158-4	2001	By the use of a strict tetracycline-regulation system, we found that the continuous suppression of beta-catenin/TCF4-mediated gene transactivation by dominant-negative TCF4B (deltaN30) reduced these piled-up foci and restored a simple monolayer of polarized columnar cells resembling normal intestinal epithelium.	Tetracycline	23-35	catenin beta 1	Rattus norvegicus	99-111
11289158-6	2001	Retroviral expression of stabilized beta-catenin (deltaN89) induced the formation of similar piled-up foci in untransformed IEC6 intestinal epithelial cells.	deltan89	50-58	catenin beta 1	Rattus norvegicus	36-48
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	80-83	catenin beta 1	Rattus norvegicus	102-114
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	Serine	63-66	catenin beta 1	Rattus norvegicus	83-95
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	Threonine	67-70	catenin beta 1	Rattus norvegicus	83-95
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	1,2-Dimethylhydrazine	127-130	catenin beta 1	Rattus norvegicus	83-95
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	chlorophyllin	142-155	catenin beta 1	Rattus norvegicus	83-95
11181454-6	2001	Interestingly, many of the mutations that substituted critical Ser/Thr residues in beta-catenin were from a single group given DMH and 0.001% chlorophyllin, in which a statistically significant increase in colon tumor multiplicity was observed compared with the group given DMH only.	1,2-Dimethylhydrazine	274-277	catenin beta 1	Rattus norvegicus	83-95
11118043-0	2000	Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats.	diisopropanolnitrosamine	108-142	catenin beta 1	Rattus norvegicus	44-56
11118043-1	2000	In the present study, we investigated mutations of the adenomatous polyposis coli (APC) and beta-catenin genes to clarify possible molecular mechanisms underlying development of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats.	diisopropanolnitrosamine	201-235	catenin beta 1	Rattus norvegicus	92-104
11118043-1	2000	In the present study, we investigated mutations of the adenomatous polyposis coli (APC) and beta-catenin genes to clarify possible molecular mechanisms underlying development of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) in rats.	bhp	237-240	catenin beta 1	Rattus norvegicus	92-104
11181454-0	2001	beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.	1,2-Dimethylhydrazine	55-76	catenin beta 1	Rattus norvegicus	0-12
11181454-0	2001	beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.	2-amino-3-methylimidazo(4,5-f)quinoline	81-120	catenin beta 1	Rattus norvegicus	0-12
11181454-1	2001	Carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the pattern of mutation differs from that found in human colon cancers.	2-amino-3-methylimidazo(4,5-f)quinoline	12-51	catenin beta 1	Rattus norvegicus	146-158
11181454-1	2001	Carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the pattern of mutation differs from that found in human colon cancers.	1,2-Dimethylhydrazine	61-82	catenin beta 1	Rattus norvegicus	146-158
11181454-1	2001	Carcinogens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 1,2-dimethylhydrazine (DMH) induce colon tumors in the rat that contain mutations in beta-catenin, but the pattern of mutation differs from that found in human colon cancers.	1,2-Dimethylhydrazine	84-87	catenin beta 1	Rattus norvegicus	146-158
11181454-3	2001	Two dietary phytochemicals, chlorophyllin and indole-3-carbinol, given post-initiation, shifted the pattern of beta-catenin mutations in rat colon tumors induced by IQ and DMH.	chlorophyllin	28-41	catenin beta 1	Rattus norvegicus	111-123
11181454-3	2001	Two dietary phytochemicals, chlorophyllin and indole-3-carbinol, given post-initiation, shifted the pattern of beta-catenin mutations in rat colon tumors induced by IQ and DMH.	indole-3-carbinol	46-63	catenin beta 1	Rattus norvegicus	111-123
11181454-3	2001	Two dietary phytochemicals, chlorophyllin and indole-3-carbinol, given post-initiation, shifted the pattern of beta-catenin mutations in rat colon tumors induced by IQ and DMH.	1,2-Dimethylhydrazine	172-175	catenin beta 1	Rattus norvegicus	111-123
11212144-6	2000	When embryos were cultured in medium supplemented with beta-catenin antisense oligodeoxynucleotide (ODN), the accumulation of beta-catenin, but not of cyclin D1, in the nascent somites and dermomyotomes was suppressed, while the number of somites was the same as that observed in control embryos.	Oligodeoxyribonucleotides	78-98	catenin beta 1	Rattus norvegicus	55-67
11212144-6	2000	When embryos were cultured in medium supplemented with beta-catenin antisense oligodeoxynucleotide (ODN), the accumulation of beta-catenin, but not of cyclin D1, in the nascent somites and dermomyotomes was suppressed, while the number of somites was the same as that observed in control embryos.	Oligodeoxyribonucleotides	78-98	catenin beta 1	Rattus norvegicus	126-138
11212144-6	2000	When embryos were cultured in medium supplemented with beta-catenin antisense oligodeoxynucleotide (ODN), the accumulation of beta-catenin, but not of cyclin D1, in the nascent somites and dermomyotomes was suppressed, while the number of somites was the same as that observed in control embryos.	Oligodeoxyribonucleotides	100-103	catenin beta 1	Rattus norvegicus	55-67
11212144-6	2000	When embryos were cultured in medium supplemented with beta-catenin antisense oligodeoxynucleotide (ODN), the accumulation of beta-catenin, but not of cyclin D1, in the nascent somites and dermomyotomes was suppressed, while the number of somites was the same as that observed in control embryos.	Oligodeoxyribonucleotides	100-103	catenin beta 1	Rattus norvegicus	126-138
10969813-1	2000	Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta-catenin.	Azoxymethane	0-12	catenin beta 1	Rattus norvegicus	120-126
10969813-1	2000	Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta-catenin.	Azoxymethane	0-12	catenin beta 1	Rattus norvegicus	143-155
10969813-1	2000	Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta-catenin.	Azoxymethane	14-17	catenin beta 1	Rattus norvegicus	120-126
10969813-1	2000	Azoxymethane (AOM)-induced colonic carcinogenesis involves a number of mutations, including those in the K-ras gene and CTNNB1, that codes for beta-catenin.	Azoxymethane	14-17	catenin beta 1	Rattus norvegicus	143-155
10965019-0	2000	More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	128-175	catenin beta 1	Rattus norvegicus	14-26
10965019-0	2000	More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	177-181	catenin beta 1	Rattus norvegicus	14-26
10965019-1	2000	Alteration of adenomatous polyposis coli (APC) is known to be an early event in neoplasia, causing activation of the beta-catenin / Tcf pathway.	tcf	132-135	catenin beta 1	Rattus norvegicus	117-129
10965019-3	2000	We therefore performed PCR-single strand conformation polymorphism analysis and direct sequencing of exon 3 of beta-catenin gene in adenomas, adenocarcinomas, and aberrant crypt foci (ACF), considered to be putative precursor lesions of colorectal neoplasias, in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) treated F344 rats.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	263-310	catenin beta 1	Rattus norvegicus	111-123
10965019-3	2000	We therefore performed PCR-single strand conformation polymorphism analysis and direct sequencing of exon 3 of beta-catenin gene in adenomas, adenocarcinomas, and aberrant crypt foci (ACF), considered to be putative precursor lesions of colorectal neoplasias, in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) treated F344 rats.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	312-316	catenin beta 1	Rattus norvegicus	111-123
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	58-78	catenin beta 1	Rattus norvegicus	35-47
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	58-78	catenin beta 1	Rattus norvegicus	102-114
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	58-78	catenin beta 1	Rattus norvegicus	102-114
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	80-83	catenin beta 1	Rattus norvegicus	35-47
10926094-5	2000	When embryos were treated with the beta-catenin antisense oligodeoxynucleotide (ODN), accumulation of beta-catenin in the otic cup was suppressed and the beta-catenin protein level was significantly less in treated embryos than in controls.	Oligodeoxyribonucleotides	80-83	catenin beta 1	Rattus norvegicus	102-114
10910031-10	2000	These results suggest that (a) there are two types of putative preneoplastic lesions in cancer-predisposed colonic mucosa, and beta-catenin signaling may contribute to the initial stage of colon carcinogenesis; and (b) HACNs are more likely to be direct precursors of colon tumors than HACAs in the rat colon carcinogenesis.	hacns	219-224	catenin beta 1	Rattus norvegicus	127-139
10910031-10	2000	These results suggest that (a) there are two types of putative preneoplastic lesions in cancer-predisposed colonic mucosa, and beta-catenin signaling may contribute to the initial stage of colon carcinogenesis; and (b) HACNs are more likely to be direct precursors of colon tumors than HACAs in the rat colon carcinogenesis.	hacas	286-291	catenin beta 1	Rattus norvegicus	127-139
10935229-0	2000	Immunohistochemical analysis of beta-catenin in N-ethyl-N-nitrosourea-induced rat gliomas: implications in regulation of angiogenesis.	Ethylnitrosourea	48-69	catenin beta 1	Rattus norvegicus	32-44
10874009-0	2000	Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.	Azoxymethane	92-104	catenin beta 1	Rattus norvegicus	22-34
10874009-2	2000	We have described the frequent mutation and an altered cellular localization of beta-catenin in rat colon adenocarcinomas induced by azoxymethane (AOM), along with up-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2.	Azoxymethane	133-145	catenin beta 1	Rattus norvegicus	80-92
10935229-3	2000	We performed an immunohistochemical analysis of beta-catenin for vascular cells (VC) in 45 N-ethyl-N-nitrosourea (ENU)-induced rat gliomas and rat normal brain tissues.	Ethylnitrosourea	91-112	catenin beta 1	Rattus norvegicus	48-60
10543253-0	1999	Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.	Diethylnitrosamine	40-58	catenin beta 1	Rattus norvegicus	0-12
10810206-4	2000	Since beta-catenin also functions as a transcription factor, nuclear beta-catenin may promote mRNA synthesis that is required for ROSE-179 cells to undergo apoptosis in response to serum/calcium withdrawal.	Calcium	187-194	catenin beta 1	Rattus norvegicus	69-81
10463579-0	1999	Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.	Diethylnitrosamine	101-122	catenin beta 1	Rattus norvegicus	38-50
10463579-0	1999	Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.	Choline	129-136	catenin beta 1	Rattus norvegicus	38-50
10463579-0	1999	Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.	Amino Acids	147-159	catenin beta 1	Rattus norvegicus	38-50
10963051-2	2000	In the first series of studies, the effect of depleting serum and calcium on the levels of the adhesion proteins N-cadherin and beta-catenin was examined.	Calcium	66-73	catenin beta 1	Rattus norvegicus	128-140
10963051-6	2000	A second series of studies demonstrated that cells that lost contact in response to the depletion of serum and calcium showed enhanced beta-catenin-dependent transcription.	Calcium	111-118	catenin beta 1	Rattus norvegicus	135-147
10963051-8	2000	When these beta-catenin transfected ROSE-179 cells were deprived of serum and calcium, beta-catenin accumulated within the nucleus and accelerated the rate at which these cells became apoptotic.	Calcium	78-85	catenin beta 1	Rattus norvegicus	11-23
10963051-8	2000	When these beta-catenin transfected ROSE-179 cells were deprived of serum and calcium, beta-catenin accumulated within the nucleus and accelerated the rate at which these cells became apoptotic.	Calcium	78-85	catenin beta 1	Rattus norvegicus	87-99
10963051-10	2000	If calcium-dependent cell contacts are broken, beta-catenin accumulates within the nucleus, where it promotes transcription and ultimately the apoptotic death of ROSE-179 cells.	Calcium	3-10	catenin beta 1	Rattus norvegicus	47-59
10590233-11	1999	In the BG/AOM group there were 10 mutations in exon 3 of the beta-catenin gene among 48 tumors evaluated, compared with six mutations in 16 tumors analyzed in the PEG/AOM group (P = 0.16).	O(6)-benzylguanine	7-9	catenin beta 1	Rattus norvegicus	61-73
10543253-0	1999	Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.	Diethylnitrosamine	40-58	catenin beta 1	Rattus norvegicus	14-20
10543253-0	1999	Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.	Diethylnitrosamine	60-63	catenin beta 1	Rattus norvegicus	0-12
10543253-0	1999	Beta-catenin (Ctnnb1) gene mutations in diethylnitrosamine (DEN)-induced liver tumors in male F344 rats.	Diethylnitrosamine	60-63	catenin beta 1	Rattus norvegicus	14-20
10543253-2	1999	To identify genetic alterations which could be involved in the chemical-induced hepatocarcinogenesis of rats, we analyzed the status of the sites in the beta-catenin gene (Ctnnb1) of liver neoplasms induced by diethylnitrosamine (DEN) in male F344 rats, using the polymerase chain reaction-single strand conformation polymorphism method.	Diethylnitrosamine	210-228	catenin beta 1	Rattus norvegicus	153-165
10543253-2	1999	To identify genetic alterations which could be involved in the chemical-induced hepatocarcinogenesis of rats, we analyzed the status of the sites in the beta-catenin gene (Ctnnb1) of liver neoplasms induced by diethylnitrosamine (DEN) in male F344 rats, using the polymerase chain reaction-single strand conformation polymorphism method.	Diethylnitrosamine	210-228	catenin beta 1	Rattus norvegicus	172-178
10543253-2	1999	To identify genetic alterations which could be involved in the chemical-induced hepatocarcinogenesis of rats, we analyzed the status of the sites in the beta-catenin gene (Ctnnb1) of liver neoplasms induced by diethylnitrosamine (DEN) in male F344 rats, using the polymerase chain reaction-single strand conformation polymorphism method.	Diethylnitrosamine	230-233	catenin beta 1	Rattus norvegicus	153-165
10543253-2	1999	To identify genetic alterations which could be involved in the chemical-induced hepatocarcinogenesis of rats, we analyzed the status of the sites in the beta-catenin gene (Ctnnb1) of liver neoplasms induced by diethylnitrosamine (DEN) in male F344 rats, using the polymerase chain reaction-single strand conformation polymorphism method.	Diethylnitrosamine	230-233	catenin beta 1	Rattus norvegicus	172-178
10543253-6	1999	Our finding that Ctnnb1 mutation was present in adenomas as well as carcinomas also suggests that the mutation is a relatively early event in DEN-induced hepatocarcinogenesis in rats.	Diethylnitrosamine	142-145	catenin beta 1	Rattus norvegicus	17-23
10026156-2	1999	We have discovered that, as part of this process, the synthetic glucocorticoid dexamethasone strongly and reversibly down-regulated the expression of fascin, an actin-bundling protein that also interacts with the adherens junction component beta-catenin.	Dexamethasone	79-92	catenin beta 1	Rattus norvegicus	241-253
10204808-0	1999	Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.	Methylazoxymethanol Acetate	76-103	catenin beta 1	Rattus norvegicus	30-42
10204808-0	1999	Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.	1-hydroxyanthraquinone	109-131	catenin beta 1	Rattus norvegicus	30-42
10204808-2	1999	In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were investigated in 20 colon tumors associated with ulcerative colitis and induced with methylazoxymethanol acetate and 1-hydroxyanthraquinone.	Methylazoxymethanol Acetate	215-242	catenin beta 1	Rattus norvegicus	114-120
10204808-2	1999	In this study, mutations in the region corresponding to N-terminal phosphorylation sites (codons 1-51) of the rat Ctnnb1 gene were investigated in 20 colon tumors associated with ulcerative colitis and induced with methylazoxymethanol acetate and 1-hydroxyanthraquinone.	1-hydroxyanthraquinone	247-269	catenin beta 1	Rattus norvegicus	114-120
9770353-8	1998	We found that E-cadherin in Triton X-100 insoluble fractions dramatically decreased in Matrigel-treated hepatocytes; however, beta-catenin strongly increased in Triton X-100 soluble fractions of Matrigel-treated hepatocytes.	Octoxynol	161-173	catenin beta 1	Rattus norvegicus	126-138
9600336-5	1998	In the azoxymethane (AOM) treated rats, overexpression and nuclear localization of beta-catenin was observed in all adenomas.	Azoxymethane	7-19	catenin beta 1	Rattus norvegicus	83-95
9515794-0	1998	High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.	heterocyclic amines	85-104	catenin beta 1	Rattus norvegicus	18-30
9515794-0	1998	High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.	heterocyclic amines	85-104	catenin beta 1	Rattus norvegicus	32-38
9515794-3	1998	All of the colon tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline that were examined (5 of 5) and 4 of 7 PhIP-induced colon tumors had mutations within or flanking codons corresponding to important phosphorylation sites in beta-catenin.	2-amino-3-methylimidazo(4,5-f)quinoline	35-74	catenin beta 1	Rattus norvegicus	232-244
9515794-5	1998	The results provide evidence for a major role of the beta-catenin/Apc pathway in the development of heterocyclic amine-induced colon tumors and give further weight to the view that regulation of beta-catenin is critical to the tumor suppressive effects of Apc during colon carcinogenesis.	Amines	113-118	catenin beta 1	Rattus norvegicus	53-65
9515794-5	1998	The results provide evidence for a major role of the beta-catenin/Apc pathway in the development of heterocyclic amine-induced colon tumors and give further weight to the view that regulation of beta-catenin is critical to the tumor suppressive effects of Apc during colon carcinogenesis.	Amines	113-118	catenin beta 1	Rattus norvegicus	195-207
9426392-4	1997	A rapid (&lt; 1 minute) and specific tyrosine phosphorylation of beta-catenin and epidermal growth factor receptor was detected in cells treated with recombinant rat TFF3.	Tyrosine	37-45	catenin beta 1	Rattus norvegicus	65-77
9426055-0	1998	Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors.	Azoxymethane	81-93	catenin beta 1	Rattus norvegicus	0-12
9426055-3	1998	In the present study, we examined the expression of beta-catenin in rat colon tumors induced by azoxymethane in comparison with adjacent normal colon mucosa by immunostaining and immunoblotting.	Azoxymethane	96-108	catenin beta 1	Rattus norvegicus	52-64
9426055-7	1998	Such frequent mutations of the beta-catenin gene in azoxymethane-induced rat colon tumors suggest that consequent alterations in the stability and localization of the protein may play an important role in this colon carcinogenesis model.	Azoxymethane	52-64	catenin beta 1	Rattus norvegicus	31-43
33822473-0	2021	Prostaglandin E2 induced cardiac hypertrophy through EP2 receptor-dependent activation of beta-catenin in 5/6 nephrectomy rats.	Dinoprostone	0-16	catenin beta 1	Rattus norvegicus	90-102
33814272-0	2021	The PPAR-gamma/SFRP5/Wnt/beta-catenin signal axis regulates the dexamethasone-induced osteoporosis.	Dexamethasone	64-77	catenin beta 1	Rattus norvegicus	25-37
33814272-12	2021	The expression of SFRP5 was reduced while Wnt and beta-catenin were increased in PPAR-gamma knockdown and Dex treated rBMSC.	Dexamethasone	106-109	catenin beta 1	Rattus norvegicus	50-62
8834786-13	1996	Presence of cAMP and replenishment of Ca2+ content in the culture medium not only allowed reformation of cell-cell contacts but also affected the relative protein ratio between the two N-cadherin/catenin complexes, increasing the relative amount of newly synthesized beta-catenin over plakoglobin at a particular stage of ARC differentiation.	Cyclic AMP	12-16	catenin beta 1	Rattus norvegicus	267-279
33822473-5	2021	PGE2 treatment enhanced active beta-catenin (non-phosphorylated) signalling through mediating EP2 and EP4 receptors.	Dinoprostone	0-4	catenin beta 1	Rattus norvegicus	31-43
32795487-0	2020	Paraquat induces pulmonary fibrosis through Wnt/beta-catenin signaling pathway and myofibroblast differentiation.	Paraquat	0-8	catenin beta 1	Rattus norvegicus	48-60
33941321-0	2021	Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/beta-Catenin/CaMKIV pathway.	Sevoflurane	0-11	catenin beta 1	Rattus norvegicus	96-108
33941321-11	2021	Sevoflurane anesthesia not only significantly increased the positive expression of CD32b, CD86, TNF-alpha and IL-6, but also decreased the expression of Wnt3a, beta-Catenin and CaMKIV.	Sevoflurane	0-11	catenin beta 1	Rattus norvegicus	160-172
33941321-12	2021	These results suggested that sevoflurane inhibited Wnt/beta-Catenin/CaMKIV pathway.	Sevoflurane	29-40	catenin beta 1	Rattus norvegicus	55-67
33941321-13	2021	CONCLUSION: Sevoflurane induces inflammation of microglia in hippocampus of neonatal rats by inhibiting Wnt/beta-Catenin/CaMKIV pathway.	Sevoflurane	12-23	catenin beta 1	Rattus norvegicus	108-120
33779364-0	2021	Surface modification of the simvastatin factor-loaded silk fibroin promotes the healing of rotator cuff injury through beta-catenin signaling.	Simvastatin	28-39	catenin beta 1	Rattus norvegicus	119-131
32795487-3	2020	By comparing the proteomic profiles of rat lung tissues using protein array in the absence or presence of PQ, the Wnt/beta-catenin signaling, as a fibrosis-related pathway, was discovered to be profoundly activated by PQ.	Paraquat	218-220	catenin beta 1	Rattus norvegicus	118-130
32795487-4	2020	The protein levels of Wnt/beta-catenin signaling components including MMP-2, beta-catenin, Wnt3a, Wnt10b, Cyclin D1, and WISP1 were increased in PQ-treated rat lung tissues.	Paraquat	145-147	catenin beta 1	Rattus norvegicus	26-38
32795487-4	2020	The protein levels of Wnt/beta-catenin signaling components including MMP-2, beta-catenin, Wnt3a, Wnt10b, Cyclin D1, and WISP1 were increased in PQ-treated rat lung tissues.	Paraquat	145-147	catenin beta 1	Rattus norvegicus	77-89
32795487-5	2020	Surprisingly, PQ was found to be able to promote lung epithelial cells and fibroblasts differentiating into myofibroblasts by activating Wnt/beta-catenin signaling pathway.	Paraquat	14-16	catenin beta 1	Rattus norvegicus	141-153
32795487-8	2020	In summary, these assays indicated that Wnt/beta-catenin signaling pathway played a regulatory role in the differentiation of lung epithelial cells and fibroblasts, and the pathogenesis of pulmonary fibrosis related to PQ.	Paraquat	219-221	catenin beta 1	Rattus norvegicus	44-56
34860284-7	2022	RESULTS: We report that THC in the posterior NASh causes distortions in emotional salience attribution, impaired sensory filtering and memory retention and heightened anxiety, through a glycogen-synthase-kinase-3 (GSK-3)-beta-catenin dependent signalling pathway.	Dronabinol	24-27	catenin beta 1	Rattus norvegicus	221-233
34968469-11	2022	SIGNIFICANCE: The down-regulation of Wnt/beta-catenin and the increase in PPARgamma by geraniol suggest that both pathways are involved in its renoprotective potential.	geraniol	87-95	catenin beta 1	Rattus norvegicus	41-53
34913065-3	2022	The purpose of the present study was to explore the role of kangxianruangan granule (KXRG)-containing serum in inhibiting the differentiation of HOCs into HCCs via the Wnt-1/beta-catenin signaling pathway.	hocs	145-149	catenin beta 1	Rattus norvegicus	174-186
34913065-14	2022	The results indicated that KXRG inhibited the differentiation of HOCs into HCCs via the Wnt-1/beta-catenin signaling pathway, which suggested the potential clinical application of KXRG for the prevention of hepatocellular carcinoma.	hocs	65-69	catenin beta 1	Rattus norvegicus	94-106
34752968-0	2022	7-Hydroxycoumarin mitigates the severity of collagen-induced arthritis in rats by inhibiting proliferation and inducing apoptosis of fibroblast-like synoviocytes via suppression of Wnt/beta-catenin signaling pathway.	7-hydroxycoumarin	0-17	catenin beta 1	Rattus norvegicus	185-197
34774660-10	2022	Knockdown of CYLD activation of the Wnt/beta-catenin pathway to restore the autophagic flux and reduce the accumulation of p62 in PA- stimulated NRCMs, while an inhibitor of the Wnt/beta-catenin pathway reversed this effect.	Palmitates	130-132	catenin beta 1	Rattus norvegicus	40-52
34781148-0	2022	Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/beta-catenin, and PI3K/Akt/mTOR signaling pathways.	Silymarin	32-41	catenin beta 1	Rattus norvegicus	156-168
34781148-0	2022	Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/beta-catenin, and PI3K/Akt/mTOR signaling pathways.	Silybin	46-55	catenin beta 1	Rattus norvegicus	156-168
34781148-10	2022	These results indicate that STE, Sm, and Sb exert anti-HCC effects through multiple pathways, including suppression of Ki-67 expression and HGF/cMet, Wnt/beta-catenin, and PI3K/Akt/mTOR pathways and enhancement of antioxidant defense mechanisms.	ste	28-31	catenin beta 1	Rattus norvegicus	154-166
34781148-10	2022	These results indicate that STE, Sm, and Sb exert anti-HCC effects through multiple pathways, including suppression of Ki-67 expression and HGF/cMet, Wnt/beta-catenin, and PI3K/Akt/mTOR pathways and enhancement of antioxidant defense mechanisms.	Silymarin	33-35	catenin beta 1	Rattus norvegicus	154-166
34781148-10	2022	These results indicate that STE, Sm, and Sb exert anti-HCC effects through multiple pathways, including suppression of Ki-67 expression and HGF/cMet, Wnt/beta-catenin, and PI3K/Akt/mTOR pathways and enhancement of antioxidant defense mechanisms.	Silybin	41-43	catenin beta 1	Rattus norvegicus	154-166
34849157-9	2022	Furthermore, the results of the present study indicated that lidocaine increased Wnt3a, beta-catenin and cyclin D1 expression levels in OGD/R-exposed cells compared with the OGD/R + saline group, thus activating the Wnt/beta-catenin signaling pathway.	Lidocaine	61-70	catenin beta 1	Rattus norvegicus	88-100
34849157-9	2022	Furthermore, the results of the present study indicated that lidocaine increased Wnt3a, beta-catenin and cyclin D1 expression levels in OGD/R-exposed cells compared with the OGD/R + saline group, thus activating the Wnt/beta-catenin signaling pathway.	Lidocaine	61-70	catenin beta 1	Rattus norvegicus	220-232
34849157-10	2022	The findings of the present study suggested that lidocaine served a protective role in OGD/R-triggered neuronal damage by activating the Wnt/beta-catenin signaling pathway; therefore, lidocaine may serve as a potential candidate for the treatment of cerebral I/R injury.	Lidocaine	49-58	catenin beta 1	Rattus norvegicus	141-153
34849157-10	2022	The findings of the present study suggested that lidocaine served a protective role in OGD/R-triggered neuronal damage by activating the Wnt/beta-catenin signaling pathway; therefore, lidocaine may serve as a potential candidate for the treatment of cerebral I/R injury.	Lidocaine	184-193	catenin beta 1	Rattus norvegicus	141-153
34752968-14	2022	CONCLUSION: 7-HC relieved the severity of rat CIA by inhibiting cell proliferation and inducing apoptosis of rheumatoid FLS via inhibition of Wnt/beta-catenin pathway.	7-hydroxycoumarin	12-16	catenin beta 1	Rattus norvegicus	146-158
34977130-8	2021	In rat-derived WB-F344 hepatic stem cell line, Sirt1 overexpression (OE) or Sirt1 activator-Resveratrol promoted HPC differentiation via activating Wnt/beta-catenin signal pathway.	Resveratrol	92-103	catenin beta 1	Rattus norvegicus	152-164
34953627-1	2022	OBJECTIVE: Surface pre-reacted glass fillers (S-PRG) can release different types of ions and in our previous study, we modified these fillers with lithium chloride (S-PRG/Li-100 mM) to induce reparative dentin formation by activating the Wnt/beta-catenin signaling pathway.	Lithium Chloride	147-163	catenin beta 1	Rattus norvegicus	242-254
34953627-1	2022	OBJECTIVE: Surface pre-reacted glass fillers (S-PRG) can release different types of ions and in our previous study, we modified these fillers with lithium chloride (S-PRG/Li-100 mM) to induce reparative dentin formation by activating the Wnt/beta-catenin signaling pathway.	s-prg	165-170	catenin beta 1	Rattus norvegicus	242-254
34977130-9	2021	Glycogen PAS staining demonstrated that Sirt1 OE promoted WB-F344 cells to differentiate into mature hepatocytes with glycogen synthesis ability, while Sirt1 inhibitor EX527 or Wnt/beta-catenin pathway inhibitor HF535 decreased glycogen positive cells.	hf535	212-217	catenin beta 1	Rattus norvegicus	181-193
34101073-0	2021	Penta-acetyl Geniposide Suppresses Migration, Invasion, and Inflammation of TNF-alpha-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes Involving Wnt/beta-Catenin Signaling Pathway.	pentaacetyl geniposide	0-23	catenin beta 1	Rattus norvegicus	161-173
34655599-10	2021	NAR treatment significantly modulated PQ-induced mRNA expressions of DRD2, DAT, LRRK2, SNCA, beta-catenin, caspase-3, BDNF genes.	naringenin	0-3	catenin beta 1	Rattus norvegicus	93-105
34655599-10	2021	NAR treatment significantly modulated PQ-induced mRNA expressions of DRD2, DAT, LRRK2, SNCA, beta-catenin, caspase-3, BDNF genes.	Paraquat	38-40	catenin beta 1	Rattus norvegicus	93-105
34863225-0	2021	Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/beta-catenin pathway.	Flavonoids	24-34	catenin beta 1	Rattus norvegicus	164-176
34863225-0	2021	Rhizoma drynariae total flavonoids combined with calcium carbonate ameliorates bone loss in experimentally induced Osteoporosis in rats via the regulation of Wnt3a/beta-catenin pathway.	Calcium Carbonate	49-66	catenin beta 1	Rattus norvegicus	164-176
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	rdtf	149-153	catenin beta 1	Rattus norvegicus	66-78
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	rdtf	149-153	catenin beta 1	Rattus norvegicus	85-97
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	rdtf	149-153	catenin beta 1	Rattus norvegicus	199-211
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	Calcium Carbonate	168-173	catenin beta 1	Rattus norvegicus	66-78
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	Calcium Carbonate	168-173	catenin beta 1	Rattus norvegicus	85-97
34863225-9	2021	Nevertheless, there was no difference in the expression of Wnt3a, beta-catenin and p-beta-catenin between osteopenic rats and RDTF treated rats, but RDTF combined with CaCO3 could activate the Wnt3a/beta-catenin pathway.	Calcium Carbonate	168-173	catenin beta 1	Rattus norvegicus	199-211
34863225-10	2021	CONCLUSIONS: RDTF combined with CaCO3 could ameliorate estrogen deficiency-induced bone loss via the regulation of Wnt3a/beta-catenin pathway.	Calcium Carbonate	32-37	catenin beta 1	Rattus norvegicus	121-133
34607529-10	2021	In conclusion, in HG-stimulated HSC-T6 cells, captopril displayed a potent ability to inhibit oxidative stress, inflammation and hepatic fibrogenesis via NF-kappaB or wnt3alpha/beta-catenin.	Captopril	46-55	catenin beta 1	Rattus norvegicus	177-189
34607529-11	2021	These results demonstrated the mechanism of captopril as well as the role of the NF-kappaB or wnt3alpha/beta-catenin on HSC-T6 activation induced by HG.	Mercury	149-151	catenin beta 1	Rattus norvegicus	104-116
34607529-0	2021	The angiotensin-converting enzyme inhibitor, captopril, suppressed Hepatic Stellate Cell activation via NF-kappaB or wnt3alpha/beta-catenin pathway.	Captopril	45-54	catenin beta 1	Rattus norvegicus	127-139
34424481-10	2021	Our results stand out together DNMT1 methylation regulates miR-152-3p to slow the progression of cardiac fibrosis by inhibiting the Wnt1/beta-catenin pathway.	mir-152-3p	59-69	catenin beta 1	Rattus norvegicus	137-149
34627778-0	2021	Inhibition of Wnt10b/beta-catenin signaling alleviates pulmonary fibrogenesis induced by paraquat in vivo and in vitro.	Paraquat	89-97	catenin beta 1	Rattus norvegicus	21-33
34674793-3	2021	Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/beta-catenin signaling and VSMC apoptosis.	PD 168368	60-68	catenin beta 1	Rattus norvegicus	156-168
34555686-13	2021	Moreover, a higher expression of AGE, a lower expression of connexin 43 and a lower amount of reticular fibers in the basal lamina of seminiferous tubules was present in rats treated with letrozole and a higher expression of beta-catenin was found in rats exposed to soya isoflavones.	soya isoflavones	267-283	catenin beta 1	Rattus norvegicus	225-237
34487706-0	2021	LncRNA H19 abrogates the protective effects of curcumin on rat carotid balloon injury via activating Wnt/beta-catenin signaling pathway.	Curcumin	47-55	catenin beta 1	Rattus norvegicus	105-117
34487706-6	2021	Furthermore, the inhibition of the expression of H19 by curcumin resulted in the inactivation of the Wnt/beta-catenin signaling.	Curcumin	56-64	catenin beta 1	Rattus norvegicus	105-117
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	22-30	catenin beta 1	Rattus norvegicus	78-90
34487706-7	2021	Overall, we show that curcumin suppresses intimal hyperplasia via the H19/Wnt/beta-catenin pathway, implying that H19 is a critical molecule in the suppression of intimal hyperplasia after balloon injury by curcumin.	Curcumin	207-215	catenin beta 1	Rattus norvegicus	78-90
34649212-14	2021	Furthermore, through activating Wnt/beta-catenin pathway with LiCl, the inhibitory effects of CKI on HCC were diminished.	Lithium Chloride	62-66	catenin beta 1	Rattus norvegicus	36-48
34959627-0	2021	Intratracheally Inhalable Nifedipine-Loaded Chitosan-PLGA Nanocomposites as a Promising Nanoplatform for Lung Targeting: Snowballed Protection via Regulation of TGF-beta/beta-Catenin Pathway in Bleomycin-Induced Pulmonary Fibrosis.	Nifedipine	26-36	catenin beta 1	Rattus norvegicus	170-182
34106520-11	2021	CONCLUSION: YS-10, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of beta-Catenin and cyclin D1 in Wnt signaling pathway.	ys-10	12-17	catenin beta 1	Rattus norvegicus	217-229
34106520-11	2021	CONCLUSION: YS-10, a novel synthesized flavonoid compound, could effectively improve erectile dysfunction in rats after BCNI by alleviating pathological impairments; this effect may associate with the upregulation of beta-Catenin and cyclin D1 in Wnt signaling pathway.	Flavonoids	39-48	catenin beta 1	Rattus norvegicus	217-229
34674793-3	2021	Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/beta-catenin signaling and VSMC apoptosis.	Phosphates	84-93	catenin beta 1	Rattus norvegicus	156-168
34191321-1	2021	Retraction: "microRNA-129-5p involved in the neuroprotective effect of dexmedetomidine on hypoxic-ischemic brain injury by targeting COL3A1 through the Wnt/beta-catenin signaling pathway in neonatal rats," by Xiu-Min Zhou, Jie Liu, Ying Wang, Shu-Li Zhang, Xin Zhao, Xiang Xu, Jian Pei, Man-He Zhang, J Cell Biochem.	Dexmedetomidine	71-86	catenin beta 1	Rattus norvegicus	156-168
34717702-10	2021	The GSK3beta/beta-catenin pathway was involved in the protective effect of LMHFV.	lmhfv	75-80	catenin beta 1	Rattus norvegicus	13-25
34647904-0	2021	Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/beta-catenin signaling pathway.	Resveratrol	0-11	catenin beta 1	Rattus norvegicus	89-101
34647904-9	2021	The activation of Wnt/beta-catenin signaling pathway was achieved by resveratrol.	Resveratrol	69-80	catenin beta 1	Rattus norvegicus	22-34
34647904-11	2021	CONCLUSIONS: Resveratrol could promote the function recovery and axonal regeneration, improve histological damage, inhibit apoptosis level after SCI through regulating Wnt/beta-catenin signaling pathway.	Resveratrol	13-24	catenin beta 1	Rattus norvegicus	172-184
34544974-0	2021	MiR-26a-5p Targets WNT5A to Protect Cardiomyocytes from Injury Due to Hypoxia/Reoxygenation Through the Wnt/beta-catenin Signaling Pathway.	mir-26a-5p	0-10	catenin beta 1	Rattus norvegicus	108-120
34410330-0	2021	Small-molecule inhibitor LF3 restrains the development of pulmonary hypertension through the Wnt/beta-catenin pathway.	LF3	25-28	catenin beta 1	Rattus norvegicus	97-109
34410330-2	2021	LF3 is a novel inhibitor of the reporter gene activity of beta-catenin/TCF4 interaction in the Wnt/beta-catenin signal pathway.	LF3	0-3	catenin beta 1	Rattus norvegicus	58-70
34410330-2	2021	LF3 is a novel inhibitor of the reporter gene activity of beta-catenin/TCF4 interaction in the Wnt/beta-catenin signal pathway.	LF3	0-3	catenin beta 1	Rattus norvegicus	99-111
34365704-7	2021	XAV939, which was a small molecule inhibitor, was used to inhibit the Wnt/beta-catenin pathway.	XAV939	0-6	catenin beta 1	Rattus norvegicus	74-86
34365704-13	2021	Exogenous administration of XAV939 suppressed the promoting effect of SCs -derived exosomes on DRG cells and the expression of downstream proteins of Wnt/beta-catenin pathway in DRG cells was also suppressed.	XAV939	28-34	catenin beta 1	Rattus norvegicus	154-166
34265292-0	2021	Luteolin mitigates tamoxifen-associated fatty liver and cognitive impairment in rats by modulating beta-catenin.	Tamoxifen	19-28	catenin beta 1	Rattus norvegicus	99-111
34265292-12	2021	As an anti-inflammatory agent, luteolin cotreatment similarly decreased the levels of hepatic inflammatory markers and increased the levels of hepatic beta-catenin in TAM-induced fatty liver.	Tamoxifen	167-170	catenin beta 1	Rattus norvegicus	151-163
34265292-13	2021	CONCLUSIONS: Luteolin improved the TAM-induced cognitive impairment and hepatic steatosis in rats by alleviating inflammation and modulating hepatic beta-catenin levels.	Tamoxifen	35-38	catenin beta 1	Rattus norvegicus	149-161
34358861-0	2021	Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and beta-catenin signaling.	triptolide	0-10	catenin beta 1	Rattus norvegicus	232-244
34358861-6	2021	Afterward, triptolide treatment inhibited RA-FLS proliferation, invasion, levels of inflammatory markers (TNF-alpha, IL-1beta, IL-6, MMP-3, and MMP-9), inactivated lncRNA RP11-83J16.1, URI1 and beta-catenin signaling, but promoted apoptosis.	triptolide	11-21	catenin beta 1	Rattus norvegicus	194-206
34358861-7	2021	However, lncRNA RP11-83J16.1 overexpression weakened the effects of triptolide on regulating RA-FLS cell behaviors, URI1 signaling and beta-catenin signaling.	triptolide	68-78	catenin beta 1	Rattus norvegicus	135-147
34358861-8	2021	In CIA model, triptolide decreased arthritis score, hyperproliferation of synovial cells, inflammation infiltration of synovial tissue, inflammatory markers (TNF-alpha, IL-1beta, IL-6, MMP-3, and MMP-9), inactivated lncRNA RP11-83J16.1, URI1 and beta-catenin signaling, but increased cell apoptosis rate of synovial tissue.	triptolide	14-24	catenin beta 1	Rattus norvegicus	246-258
34358861-10	2021	CONCLUSION: Triptolide decreases RA-FLS proliferation, invasion, inflammation and presents a therapeutic effect in CIA model via inactivating lncRNA RP11-83J16.1 mediated URI1 and beta-catenin signaling.	triptolide	12-22	catenin beta 1	Rattus norvegicus	180-192
34544974-3	2021	The activity of the Wnt/beta-catenin signaling pathway was up-regulated; the level of LDH released was significantly increased; and activities of SOD and GSH-PX were significantly decreased.	Glutathione	154-157	catenin beta 1	Rattus norvegicus	24-36
34544974-5	2021	The overexpression of miR-26a-5p could reduce the expression level of WNT5A, the activity of the Wnt/beta-catenin signaling pathway, and the apoptosis rate and restore the cell viability.These results suggest that miR-26a-5p can target WNT5A and thus, inhibit the Wnt/beta-catenin signaling pathway activity, inhibiting H/R-induced cardiomyocyte injury and apoptosis.	mir-26a-5p	214-224	catenin beta 1	Rattus norvegicus	101-113
34544974-5	2021	The overexpression of miR-26a-5p could reduce the expression level of WNT5A, the activity of the Wnt/beta-catenin signaling pathway, and the apoptosis rate and restore the cell viability.These results suggest that miR-26a-5p can target WNT5A and thus, inhibit the Wnt/beta-catenin signaling pathway activity, inhibiting H/R-induced cardiomyocyte injury and apoptosis.	mir-26a-5p	214-224	catenin beta 1	Rattus norvegicus	268-280
34166702-11	2021	We confirm adverse effects on protein expressions including Notch1, Jagged1, HEY1, Wnt 1, beta-catenin and RUNX2 following daily VPA treatment in OVX female rats.	Valproic Acid	129-132	catenin beta 1	Rattus norvegicus	90-102
34545285-0	2021	Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with Abeta-Induced Alzheimer"s Disease Rats Based on the Wnt/beta-catenin Pathway.	Lycopene	0-8	catenin beta 1	Rattus norvegicus	122-134
34569214-0	2021	(Tobramycin promotes fracture healing by upregulating expressions of ALP and RUNX2 proteins through activating Wnt/beta-catenin pathway).	Tobramycin	1-11	catenin beta 1	Rattus norvegicus	115-127
34569214-10	2021	CONCLUSION: Tobramycin could promote osteoblast differentiation and fracture healing by stimulating Wnt / beta-catenin signaling pathway, up regulating expression of ALP and RUNX2.	Tobramycin	12-22	catenin beta 1	Rattus norvegicus	106-118
34631449-3	2021	Scl-Ab activates the canonical Wnt (cWnt)-beta-catenin pathway, leading to an increase in bone formation and decrease in bone resorption.	scl-ab	0-6	catenin beta 1	Rattus norvegicus	42-54
34545285-1	2021	Objective: To investigate the effects of lycopene-loaded microemulsion (LME) on the cognitive function and neurogenesis in the dentate gyrus (DG) of the hippocampus and subventricular (SVZ) region of rats with amyloid beta- (Abeta-) induced Alzheimer"s disease (AD) and its mechanism based on the Wnt/beta-catenin pathway.	Lycopene	41-49	catenin beta 1	Rattus norvegicus	301-313
34166702-12	2021	Our current study demonstrated that intermittent administration of sodium valproate has a protective effect on bone health in OVX rats and these effects may be achieved by activating Notch/Wnt/beta-catenin/RUNX2 signal axis.	Valproic Acid	67-83	catenin beta 1	Rattus norvegicus	193-205
34462377-11	2021	For the hypothesis verification, this study intends to establish chronic cerebral hypoperfusion (CCH) rat model, explore the improvement effect of enriched environment on VCI, detect the changes in plasticity of synaptic morphology and investigate the regulatory mechanism NMDAR-Ca2+-ActA-Wnt/beta-catenin signaling loop, providing a therapeutic method for the treatment of CCH.	1-acetyl-2-(coumariniminecarboxamide-3-yl)hydrazine	374-377	catenin beta 1	Rattus norvegicus	293-305
34352441-5	2021	The rat CRC model was induced by AOM/DSS, in which we verified activity in the Wnt/beta-catenin pathway by examining GSK3beta phosphorylation.	Azoxymethane	33-36	catenin beta 1	Rattus norvegicus	83-95
34352441-8	2021	IM-12 reversed the Wnt/beta-catenin-activated state change induced by RNF6 silencing and the inhibition of cell proliferation, tumorigenicity, invasion and migration.	IM-12	0-5	catenin beta 1	Rattus norvegicus	23-35
34425536-0	2021	Dysregulations of miR-503-5p and Wnt/beta-catenin pathway coordinate in mediating cadmium-induced kidney fibrosis.	Cadmium	82-89	catenin beta 1	Rattus norvegicus	37-49
34119828-12	2021	The collected exosomes containing miR-129-5p showed the inhibition effect in osteoblast differentiation and decreased the expression osteoblastic markers by targeting FZD4/beta-catenin signaling pathway.	mir-129-5p	34-44	catenin beta 1	Rattus norvegicus	172-184
34119828-13	2021	Therefore, the exosomes containing miR-129-5p in DM rats inhibits osteoblast differentiation by targeting FZD4/beta-catenin pathway.	mir-129-5p	35-45	catenin beta 1	Rattus norvegicus	111-123
34425536-10	2021	Given the well established involvement of Wnt/beta-catenin pathway in fibrosis, this study suggested that dysregulations of Wnts and miR-503-5p coordinate in mediating cadmium-induced kidney fibrosis.	Cadmium	168-175	catenin beta 1	Rattus norvegicus	46-58
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Rosuvastatin Calcium	31-43	catenin beta 1	Rattus norvegicus	121-133
34102194-10	2021	SIGNIFICANCE: Vitamin D and/or rosuvastatin alleviated diabetes-induced neuropathy by suppressing Notch1 and Wnt-10alpha/beta-catenin; modulating TGF-beta/Smad-7 signaling pathways; and enhancing mitochondrial function, which lessened neuronal degeneration, demyelination, and fibrosis.	Vitamin D	14-23	catenin beta 1	Rattus norvegicus	121-133
34392654-11	2021	The protein levels of Wnt1 and beta-catenin were obviously up-regulated with DJC treatment, while the SOST and DDK1 were markedly down-regulated with DJC treatment.	djc	77-80	catenin beta 1	Rattus norvegicus	31-43
34392654-11	2021	The protein levels of Wnt1 and beta-catenin were obviously up-regulated with DJC treatment, while the SOST and DDK1 were markedly down-regulated with DJC treatment.	djc	150-153	catenin beta 1	Rattus norvegicus	31-43
34358348-7	2022	Meanwhile, CAA-Ca treatment raised beta-catenin levels and lowered Dickkopf1 (DKK1) levels in the Wnt signaling pathway of osteoblasts, which can promote calcium absorption and bone formation through.	caa-ca	11-17	catenin beta 1	Rattus norvegicus	35-47
34358348-7	2022	Meanwhile, CAA-Ca treatment raised beta-catenin levels and lowered Dickkopf1 (DKK1) levels in the Wnt signaling pathway of osteoblasts, which can promote calcium absorption and bone formation through.	Calcium	154-161	catenin beta 1	Rattus norvegicus	35-47
34216755-0	2021	Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating beta-catenin and prevents ovariectomy-induced bone loss.	hydroxysafflor yellow A	0-23	catenin beta 1	Rattus norvegicus	97-109
34370635-0	2021	Peptide5 attenuates rtPA related brain microvascular endothelial cells reperfusion injury via the Wnt/beta-catenin signalling pathway.	Peptide5	0-8	catenin beta 1	Rattus norvegicus	102-114
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Methylnitrosourea	67-70	catenin beta 1	Rattus norvegicus	41-53
34325589-10	2021	Strong expression of BCL-2, IL-6, COX 2, beta-catenin and iNOS in (NMU + BaP)-administered rats were observed.	Benzo(a)pyrene	73-76	catenin beta 1	Rattus norvegicus	41-53
34283317-3	2021	The purpose of the present study was to investigate the effects of a known toxic agent, benzo(a)pyrene (BaP), on the regulation and interaction between GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	88-102	catenin beta 1	Rattus norvegicus	165-177
34283317-3	2021	The purpose of the present study was to investigate the effects of a known toxic agent, benzo(a)pyrene (BaP), on the regulation and interaction between GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	104-107	catenin beta 1	Rattus norvegicus	165-177
34283317-5	2021	We also found BaP-mediated downregulation of Wnt/beta-catenin signaling related to the PI3K-Akt pathway.	Benzo(a)pyrene	14-17	catenin beta 1	Rattus norvegicus	49-61
34283317-8	2021	Despite the inverse correlation between Wnt/beta-catenin signaling and Cx43 promoter activation as indicated by downregulation of beta-catenin nuclear translocation and upregulation of Cx43 promoter activation involving HNF3beta, BaP treatment decreased the Cx43 protein expression, which was associated with protein degradation, possibly through protein kinase C activation.	Benzo(a)pyrene	230-233	catenin beta 1	Rattus norvegicus	44-56
34283317-9	2021	In conclusion, our results revealed the mechanism of BaP-induced inhibition of GJIC and Wnt/beta-catenin signaling.	Benzo(a)pyrene	53-56	catenin beta 1	Rattus norvegicus	92-104
34234489-0	2021	Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic beta-Catenin in Hypothyroid Rats.	thymoquinone	0-12	catenin beta 1	Rattus norvegicus	86-98
34234489-2	2021	Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression.	Propylthiouracil	59-75	catenin beta 1	Rattus norvegicus	279-291
34234489-2	2021	Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression.	Propylthiouracil	77-80	catenin beta 1	Rattus norvegicus	279-291
34234489-2	2021	Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression.	thymoquinone	155-167	catenin beta 1	Rattus norvegicus	279-291
34234489-12	2021	Conclusion: TQ alleviated PTU-induced hypothyroidism changes in insulin homeostasis and pancreatic beta cells mostly through its antioxidant effect as well as up-regulation of pancreatic beta-catenin expression.	thymoquinone	12-14	catenin beta 1	Rattus norvegicus	187-199
34234489-12	2021	Conclusion: TQ alleviated PTU-induced hypothyroidism changes in insulin homeostasis and pancreatic beta cells mostly through its antioxidant effect as well as up-regulation of pancreatic beta-catenin expression.	Propylthiouracil	26-29	catenin beta 1	Rattus norvegicus	187-199
34326686-0	2021	Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/beta-catenin Pathway in Endometriosis.	ferulic acid	15-27	catenin beta 1	Rattus norvegicus	123-135
34326686-0	2021	Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/beta-catenin Pathway in Endometriosis.	tetramethylpyrazine	29-41	catenin beta 1	Rattus norvegicus	123-135
34326686-0	2021	Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/beta-catenin Pathway in Endometriosis.	tetrahydropalmatine	46-65	catenin beta 1	Rattus norvegicus	123-135
34090498-10	2021	Halting neurodegeneration in DOX-induced chemobrain was achieved through epigenetic induction of key factors in Wnt/beta-catenin and hedgehog signaling pathways mediated primarily by the most abundant secreted exosomal miRNAs (miR-21-5p, miR-125b-5p, miR-199a-3p, miR-24-3p, let-7a-5p).	Doxorubicin	29-32	catenin beta 1	Rattus norvegicus	116-128
34090498-12	2021	CONCLUSIONS: BMSCs and their derived exosomes offer neuroprotection against DOX-induced chemobrain via genetic and epigenetic abrogation of hippocampal neurodegeneration through modulating Wnt/beta-catenin and hedgehog signaling pathways and through reducing inflammatory, apoptotic, and oxidative stress state.	Doxorubicin	76-79	catenin beta 1	Rattus norvegicus	193-205
34667438-10	2021	The miR-224, miR-200a, and beta-catenin expression, when treated with PA alone or with oxaliplatin, was decreased markedly in comparison with the positive control group.	Phytic Acid	70-72	catenin beta 1	Rattus norvegicus	27-39
34667438-10	2021	The miR-224, miR-200a, and beta-catenin expression, when treated with PA alone or with oxaliplatin, was decreased markedly in comparison with the positive control group.	Oxaliplatin	87-98	catenin beta 1	Rattus norvegicus	27-39
34174018-0	2021	Prenatal intake of omega-3 promotes Wnt/beta-catenin signaling pathway, and preserves integrity of the blood-brain barrier in preeclamptic rats.	omega-3	19-26	catenin beta 1	Rattus norvegicus	40-52
34174018-4	2021	We investigate the protective effect of omega-3 against neurovascular complication of preeclampsia and its relation to Wnt/beta-catenin signaling pathway.	omega-3	40-47	catenin beta 1	Rattus norvegicus	123-135
34174018-7	2021	RESULTS: We found that omega-3 supplementation significantly improved cognitive functions and EEG amplitude, decreased blood pressure, water contents of brain tissues, sFlt-1, oxidative stress, proteinuria, and enhanced Wnt\beta-catenin proteins.	omega-3	23-30	catenin beta 1	Rattus norvegicus	224-236
34122101-0	2021	Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/beta-Catenin Signaling Pathway.	Flavonoids	6-16	catenin beta 1	Rattus norvegicus	148-160
34122101-10	2021	Cell Counting Kit-8 (CCK-8) method, Alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining, Western blot, RT-PCR and other methods were used to detect the effects of TFRD on the proliferation of osteoblasts and the regulation of Wnt/beta-catenin signaling pathway.	tfrd	172-176	catenin beta 1	Rattus norvegicus	239-251
34122101-12	2021	Moreover, the expression of Wnt/beta-catenin and osteogenesis-related proteins in bone tissue of TFRD group was more than that in other groups.	tfrd	97-101	catenin beta 1	Rattus norvegicus	32-44
34093849-7	2021	The La3+ dopants in the scaffolds promote proliferation and osteogenic differentiation of rBMSCs-OVX by activating Wnt/beta-catenin pathway, leading to high expression of ALP, Runx-2, COL-1 and OCN genes.	lanthanum(3+)	4-8	catenin beta 1	Rattus norvegicus	119-131
34100378-0	2021	Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation of fetuin-A and GLP-1 with involvement of ERK1/2/NF-kappaB and Wnt1/beta-catenin signaling pathways.	Gallic Acid	27-38	catenin beta 1	Rattus norvegicus	184-196
34100378-7	2021	Furthermore, our results discovered that gallic acid could diminish the DM-induced hepatic damage via upregulated hepatic mRNA expression of GLUT-4, Wnt1 and beta-catenin with inhibitory effects on the elevated expression of ERK1/2/NF-kappaB.	Gallic Acid	41-52	catenin beta 1	Rattus norvegicus	158-170
35523286-0	2022	Infliximab and/or MESNA alleviate doxorubicin-induced Alzheimer"s disease-like pathology in rats: A new insight into TNF-alpha/Wnt/beta-catenin signaling pathway.	Mesna	18-23	catenin beta 1	Rattus norvegicus	131-143
34689858-10	2021	), a potent chain-breaking antioxidant significantly enhanced CBF and reduced BBB breakdown, edema formation, beta catenin expression and brain pathology in METH exposed rats after CHI at HA.	Methamphetamine	157-161	catenin beta 1	Rattus norvegicus	110-122
35523286-0	2022	Infliximab and/or MESNA alleviate doxorubicin-induced Alzheimer"s disease-like pathology in rats: A new insight into TNF-alpha/Wnt/beta-catenin signaling pathway.	Doxorubicin	34-45	catenin beta 1	Rattus norvegicus	131-143
35523286-1	2022	AIMS: The current study aimed to elucidate the neurotoxic potential of DOX to induce AD-like pathology paying attention to the role of wingless-integrated/beta-catenin (Wnt/beta-catenin) signaling pathway.	Doxorubicin	71-74	catenin beta 1	Rattus norvegicus	155-167
35523286-1	2022	AIMS: The current study aimed to elucidate the neurotoxic potential of DOX to induce AD-like pathology paying attention to the role of wingless-integrated/beta-catenin (Wnt/beta-catenin) signaling pathway.	Doxorubicin	71-74	catenin beta 1	Rattus norvegicus	173-185
34782574-4	2022	We found that the enriched environment for offspring increased nestin and Ki67 levels in hippocampal tissue, increased hippocampal neurogenesis, inhibited glycogen synthase kinase 3beta activity, and increased the expression of cell proliferation-related beta-catenin and apoptosis-related Bcl-2, indicating that an enriched environment reduces sevoflurane-induced damage by increasing the proliferation of stem cells in the hippocampus.	Sevoflurane	345-356	catenin beta 1	Rattus norvegicus	255-267
35527292-0	2022	Neuroprotective Effect of Baicalein Against Oxaliplatin-Induced Peripheral Neuropathy: Impact on Oxidative Stress, Neuro-inflammation and WNT/beta-Catenin Signaling.	baicalein	26-35	catenin beta 1	Rattus norvegicus	142-154
35527292-8	2022	Additionally, baicalein treatment resulted in a significant downregulation of active beta-catenin, Wnt5b and Wnt3a proteins.	baicalein	14-23	catenin beta 1	Rattus norvegicus	85-97
35483665-5	2022	In vitro, resveratrol attenuated the activation of beta-catenin induced by high-phosphate and inhibited the expression of Runx2, a downstream effector of Wnt/beta-catenin signaling during osteogenic transdifferentiation of VSMCs.	Resveratrol	10-21	catenin beta 1	Rattus norvegicus	51-63
35483665-5	2022	In vitro, resveratrol attenuated the activation of beta-catenin induced by high-phosphate and inhibited the expression of Runx2, a downstream effector of Wnt/beta-catenin signaling during osteogenic transdifferentiation of VSMCs.	Resveratrol	10-21	catenin beta 1	Rattus norvegicus	158-170
35483665-5	2022	In vitro, resveratrol attenuated the activation of beta-catenin induced by high-phosphate and inhibited the expression of Runx2, a downstream effector of Wnt/beta-catenin signaling during osteogenic transdifferentiation of VSMCs.	Phosphates	80-89	catenin beta 1	Rattus norvegicus	51-63
35483665-9	2022	In summary, these findings suggest that resveratrol possesses a vascular protective effect on retarding high-phosphate-induced osteogenic transdifferentiation of VSMCs and AMC in CKD by targeting Wnt/beta-catenin signaling, which may, to a large extent, via impeding Wnt secretion.	Resveratrol	40-51	catenin beta 1	Rattus norvegicus	200-212
35461824-9	2022	Our cumulative results suggest that verdiperstat alleviates ALI by strengthening VE-cadherin and claudin 5 through the inhibition of MPO/mu-calpain/beta-catenin activation.	AZD3241	36-48	catenin beta 1	Rattus norvegicus	148-160
35359227-7	2022	PRI-724, a selective inhibitor of beta-catenin, was able to reverse the therapeutic effect of EX-4 in vivo and in vitro.	ICG 001	0-7	catenin beta 1	Rattus norvegicus	34-46
35181487-14	2022	GFC-containing serum could induce cell apoptosis, make the cell cycle stagnated in G0/G1 phase to inhibiting the proliferation and reduce the expression of Wnt1, beta-Catenin, Cyclin D1, TCF1/TCF7, and C-myc in control-shRNA cells, while had no significant effect on Med12-shRNA cells.	5'-O-[(S)-{[(S)-[(S)-chloro(fluoro)phosphonomethyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2'-deoxyguanosine	0-3	catenin beta 1	Rattus norvegicus	162-174
35636077-0	2022	Coenzyme Q10 attenuates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation via Wnt3alpha/beta-catenin/GSK-3beta signaling in unilateral ureteral obstruction.	coenzyme Q10	0-12	catenin beta 1	Rattus norvegicus	109-121
35500294-0	2022	Anticonvulsive and Neuroprotective Effects of Eupafolin in Rats Are Associated with the Inhibition of Glutamate Overexcitation and Upregulation of the Wnt/beta-Catenin Signaling Pathway.	eupafolin	46-55	catenin beta 1	Rattus norvegicus	155-167
35500294-9	2022	In addition, eupafolin notably reversed KA seizure-induced alterations in alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit GluR2, glutamate decarboxylase 67 (GAD67, GABAergic enzyme), and Wnt signaling-related proteins, including porcupine, Wnt1, phosphorylated-glycogen synthase kinase-3beta, beta-catenin, and Bcl-2 in the hippocampus.	eupafolin	13-22	catenin beta 1	Rattus norvegicus	319-331
35597989-0	2022	Roxadustat promotes osteoblast differentiation and prevents estrogen deficiency-induced bone loss by stabilizing HIF-1alpha and activating the Wnt/beta-catenin signaling pathway.	roxadustat	0-10	catenin beta 1	Rattus norvegicus	147-159
35597989-15	2022	Roxadustat activated the HIF-1alpha and Wnt/beta-catenin pathways.	roxadustat	0-10	catenin beta 1	Rattus norvegicus	44-56
35597989-16	2022	HIF-1alpha knockdown or Wnt/beta-catenin pathway inhibition significantly attenuated roxadustat-promoted osteoblast differentiation.	roxadustat	85-95	catenin beta 1	Rattus norvegicus	28-40
35597989-18	2022	Roxadustat upregulated the protein expression levels of the osteogenic markers, HIF-1alpha and beta-catenin in the bone tissue of OVX rats.	roxadustat	0-10	catenin beta 1	Rattus norvegicus	95-107
35623224-0	2022	Sodium pentaborate pentahydrate promotes hair growth through the Wnt/beta-catenin pathway and growth factors.	Sodium pentaborate pentahydrate	0-31	catenin beta 1	Rattus norvegicus	69-81
35581162-10	2022	Circ_0000284 was upregulated in serum of AP patients and caerulein-induced AR42J cells, while Wnt/beta-catenin pathway was inactivated.	Ceruletide	57-66	catenin beta 1	Rattus norvegicus	98-110
35385194-0	2022	Panax notoginseng saponins improves healing of high glucose-induced wound through the GSK-3beta/beta-catenin pathway.	Saponins	18-26	catenin beta 1	Rattus norvegicus	96-108
35526705-0	2022	Melatonin and zinc supplements with physical and mental activities subside neurodegeneration and hepatorenal injury induced by aluminum chloride in rats: Inclusion of GSK-3beta-Wnt/beta-catenin signaling pathway.	Aluminum Chloride	127-144	catenin beta 1	Rattus norvegicus	181-193
35526705-12	2022	CONCLUSIONS: Combining Mel and Zn supplements with PMA defends against AlCl3-induced AD by modulating GSK-3beta-Wnt/beta-catenin signaling and palliates the associated hepatorenal dysfunction.	Zinc Sulfate	31-33	catenin beta 1	Rattus norvegicus	116-128
35526705-12	2022	CONCLUSIONS: Combining Mel and Zn supplements with PMA defends against AlCl3-induced AD by modulating GSK-3beta-Wnt/beta-catenin signaling and palliates the associated hepatorenal dysfunction.	Tetradecanoylphorbol Acetate	51-54	catenin beta 1	Rattus norvegicus	116-128
35526705-12	2022	CONCLUSIONS: Combining Mel and Zn supplements with PMA defends against AlCl3-induced AD by modulating GSK-3beta-Wnt/beta-catenin signaling and palliates the associated hepatorenal dysfunction.	Aluminum Chloride	71-76	catenin beta 1	Rattus norvegicus	116-128
35635079-0	2022	Dexmedetomidine protects H9C2 rat cardiomyocytes against hypoxia/reoxygenation injury by regulating the long non-coding RNA colon cancer-associated transcript 1/microRNA-8063/Wnt/beta-catenin axis.	Dexmedetomidine	0-15	catenin beta 1	Rattus norvegicus	179-191
35635079-8	2022	Dex pretreatment increased H/R H9C2 cell viability and CCAT1 expression, while decreasing the cell apoptosis and Wnt3a, Wnt5a, and beta-catenin protein levels.	Dexmedetomidine	0-3	catenin beta 1	Rattus norvegicus	131-143
35635079-10	2022	These results revealed that CCAT1, a sponge for miR-8063, is involved in Dex-mediated H9C2 cell H/R injury by negatively targeting miR-8063 and inactivating the Wnt/beta-catenin pathway.	mir-8063	48-56	catenin beta 1	Rattus norvegicus	165-177
35635079-10	2022	These results revealed that CCAT1, a sponge for miR-8063, is involved in Dex-mediated H9C2 cell H/R injury by negatively targeting miR-8063 and inactivating the Wnt/beta-catenin pathway.	Dexmedetomidine	73-76	catenin beta 1	Rattus norvegicus	165-177
35635079-11	2022	Dex protects H9C2 cells from H/R impairment by regulating the lncRNA CCAT1/miR-8063/Wnt/beta-catenin axis.	Dexmedetomidine	0-3	catenin beta 1	Rattus norvegicus	88-100
35347430-11	2022	After addition of XAV-939, reduction of beta-catenin and the downstream (Osterix and Runx2) were manifested.	XAV939	18-25	catenin beta 1	Rattus norvegicus	40-52
35432561-0	2022	Baicalin Attenuates Continuous Activation of beta-Catenin Induced by Lipopolysaccharide (LPS) and Depression Complicated by Infertility in Male Rats.	baicalin	0-8	catenin beta 1	Rattus norvegicus	45-57
35432561-3	2022	This study aimed to investigate the role of BA in alleviating inflammatory factor-induced DCMI by regulating beta-catenin.	baicalin	44-46	catenin beta 1	Rattus norvegicus	109-121
35432561-15	2022	BA relieved the symptoms of DCMI by regulating beta-catenin.	baicalin	0-2	catenin beta 1	Rattus norvegicus	47-59
35432561-15	2022	BA relieved the symptoms of DCMI by regulating beta-catenin.	dcmi	28-32	catenin beta 1	Rattus norvegicus	47-59
35432561-17	2022	Conclusion: BA modulated beta-catenin in the relief of inflammatory factor-induced DCMI.	baicalin	12-14	catenin beta 1	Rattus norvegicus	25-37
35354071-0	2022	Renoprotective effect of bone marrow mesenchymal stem cells with hyaluronic acid against adriamycin- induced kidney fibrosis via inhibition of Wnt/beta-catenin pathway.	Hyaluronic Acid	65-80	catenin beta 1	Rattus norvegicus	147-159
35563828-7	2022	Anti-Notch2 antibody treatment ameliorated MTX treatment-induced increases in osteoclast density and NFATc1 and RANKL expression, and attenuated MTX-induced bone marrow adiposity via regulating Wnt/beta-catenin signalling and PPARgamma expression.	Methotrexate	145-148	catenin beta 1	Rattus norvegicus	198-210
35305975-0	2022	Wnt/beta-catenin antagonist pyrvinium rescues high dose isoproterenol induced cardiotoxicity in rats: Biochemical and immunohistological evidences.	pyrvinium	28-37	catenin beta 1	Rattus norvegicus	4-16
35305975-4	2022	Wnt/beta-catenin inhibitor pyrvinium (60 mug/kg, p.o) was given 2h prior and glibenclamide at a dose of 5 mg/kg; p.o, 2 h after ISO injection.	pyrvinium	27-36	catenin beta 1	Rattus norvegicus	4-16
35305975-9	2022	ISO administration enhanced beta-catenin gene expression and transcription which promoted oxidative and nitrosative stress, inflammatory cytokine release, reduced ATP levels, induced over-expression of fibrotic proteins resulting in cardiac hypertrophy, myocardial necrosis, functional and histological changes.	Isoproterenol	0-3	catenin beta 1	Rattus norvegicus	28-40
35305975-9	2022	ISO administration enhanced beta-catenin gene expression and transcription which promoted oxidative and nitrosative stress, inflammatory cytokine release, reduced ATP levels, induced over-expression of fibrotic proteins resulting in cardiac hypertrophy, myocardial necrosis, functional and histological changes.	Adenosine Triphosphate	163-166	catenin beta 1	Rattus norvegicus	28-40
35305975-10	2022	However, antagonism of Wnt/beta-catenin pathway attenuated these ISO induced pathological manifestations.	Isoproterenol	65-68	catenin beta 1	Rattus norvegicus	27-39
35305975-11	2022	Notably, the co-treatment with ATP-sensitive K+ channel inhibitor partially, reduced the cardioprotective effects of Wnt/beta-catenin blocker pyrvinium in ISO rats.	pyrvinium	142-151	catenin beta 1	Rattus norvegicus	121-133
35305975-12	2022	Thus Wnt/beta-catenin inhibition exhibits cardioprotective in ISO model by anti-oxidant, anti-inflammatory, anti-fibrotic properties and by possible involvement of ATP-sensitive potassium channel activation.	Isoproterenol	62-65	catenin beta 1	Rattus norvegicus	9-21
35385194-0	2022	Panax notoginseng saponins improves healing of high glucose-induced wound through the GSK-3beta/beta-catenin pathway.	Glucose	52-59	catenin beta 1	Rattus norvegicus	96-108
35465693-0	2022	Selenium nanoparticles stimulate osteoblast differentiation via BMP-2/MAPKs/beta-catenin pathway in diabetic osteoporosis.	Selenium	0-8	catenin beta 1	Rattus norvegicus	76-88
35093471-0	2022	Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/beta-Catenin and CREB pathway.	dapagliflozin	0-13	catenin beta 1	Rattus norvegicus	118-130
35331526-10	2022	Beta-catenin and Bcl-2 proteins expression was decreased and caspase 3 expression was significantly increased in the quercetin group versus to control group.	Quercetin	117-126	catenin beta 1	Rattus norvegicus	0-12
35387224-8	2022	Moreover, treatment with H2O2 in primary cultured astrocyte significantly increased beta-catenin and Caspase-3 expression, while decreased SIRT1 and Forkhead box O- (FOXO-) 4.	Hydrogen Peroxide	25-29	catenin beta 1	Rattus norvegicus	84-96
35217812-0	2022	Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3beta/beta-catenin signaling pathway.	salvianolic acid A	28-46	catenin beta 1	Rattus norvegicus	138-150
35370672-6	2022	Results: Polydatin could significantly restore the body function, reduce MCT-induced PAH injury, reduce serum biochemical indices; polydatin could effectively inhibit EndMT process by decreasing the expression of N-cadherin, beta-catenin and vimentin; polydatin could down-regulate TAGLN expression and increase PECAM1 expression to reduce pulmonary vascular remodeling.	polydatin	9-18	catenin beta 1	Rattus norvegicus	225-237
35370672-6	2022	Results: Polydatin could significantly restore the body function, reduce MCT-induced PAH injury, reduce serum biochemical indices; polydatin could effectively inhibit EndMT process by decreasing the expression of N-cadherin, beta-catenin and vimentin; polydatin could down-regulate TAGLN expression and increase PECAM1 expression to reduce pulmonary vascular remodeling.	polydatin	131-140	catenin beta 1	Rattus norvegicus	225-237
35269974-0	2022	Tankyrase Regulates Neurite Outgrowth through Poly(ADP-ribosyl)ation-Dependent Activation of beta-Catenin Signaling.	poly(adp-ribosyl)	46-63	catenin beta 1	Rattus norvegicus	93-105
35177206-0	2022	Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/beta-catenin signaling in methotrexate-induced rat ileal mucositis.	Methotrexate	0-12	catenin beta 1	Rattus norvegicus	103-115
35177206-0	2022	Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/beta-catenin signaling in methotrexate-induced rat ileal mucositis.	Nitric Oxide	76-88	catenin beta 1	Rattus norvegicus	103-115
35177206-2	2022	Methotrexate induced the mRNA expressions of the Wnt/beta-catenin target genes Wnt3a, Sox9, and Lgr5 and the Wnt-antagonist gene sFRP-1 and the protein expressions of Lgr5 and sFRP-1.	Methotrexate	0-12	catenin beta 1	Rattus norvegicus	53-65
35177206-4	2022	A non-selective NO inhibitor inhibited the methotrexate induction of Wnt/beta-catenin target genes and Lgr5+ cells but enhanced that of sFRP-1 expression.	Methotrexate	43-55	catenin beta 1	Rattus norvegicus	73-85
35177206-5	2022	Thus, methotrexate mediates the integrity of intestinal stem cells partly through NO-dependent Wnt/beta-catenin signaling and may enhance tolerability to methotrexate-induced injury.	Methotrexate	6-18	catenin beta 1	Rattus norvegicus	99-111
35016879-0	2022	Mitigation of dexamethasone-induced nephrotoxicity by modulating the activity of adrenergic receptors: Implication of Wnt/beta-arrestin2/beta-catenin pathway.	Dexamethasone	14-27	catenin beta 1	Rattus norvegicus	137-149
35016879-8	2022	Results: Dexamethasone induced glomerular damage, proteinuria, renal oxidative stress and upregulated the renal Wnt/beta-arrestin2/beta-catenin pathway and the profibrotic signals.	Dexamethasone	9-22	catenin beta 1	Rattus norvegicus	131-143
35016879-14	2022	Conclusion: Dexamethasone induces nephrotoxicity, possibly, by upregulating the Wnt/beta-arrestin2/beta-catenin pathway.	Dexamethasone	12-25	catenin beta 1	Rattus norvegicus	99-111
35434452-11	2022	The strong stimulation of osteopontin was blocked by lithium chloride, indicating involvement of Wnt/beta-catenin signaling.	Lithium Chloride	53-69	catenin beta 1	Rattus norvegicus	101-113
35183930-12	2022	Further, SMS treatment induced the accumulation of beta-catenin.	sms	9-12	catenin beta 1	Rattus norvegicus	51-63
35018959-4	2022	Moreover, the potential targets of BIIP affecting OA in vivo were studied by proteomics, and the effects of BIIP on OA through signaling pathways, such as NF-kappaB, Wnt/beta-catenin and MAPK, were further explored at mRNA and protein levels.	biip	108-112	catenin beta 1	Rattus norvegicus	170-182
35183930-13	2022	After 14 days of SMS treatment, beta-catenin protein underwent nuclear translocation and bound to the LEF1 receptor in the nucleus, which regulated c-Myc and Cyclin D1 factors to activate Wnt/beta-catenin signaling and promoted differentiation of WB-F344 cells.	sms	17-20	catenin beta 1	Rattus norvegicus	192-204
35183930-16	2022	Concurrently, SMS treatment induced hepatic stem cell differentiation by activating Wnt/beta-catenin signaling in vivo.	sms	14-17	catenin beta 1	Rattus norvegicus	88-100
35130601-0	2022	(Experimental study of proteasome inhibitor MG132 up-regulates Wnt/beta-catenin signaling pathway to improve osteoporosis).	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	44-49	catenin beta 1	Rattus norvegicus	67-79
35089423-10	2022	Mechanistic studies reveal that methylation of arginine residue 93 in beta-catenin decreases the activity of beta-catenin.	Arginine	47-55	catenin beta 1	Rattus norvegicus	70-82
35089423-10	2022	Mechanistic studies reveal that methylation of arginine residue 93 in beta-catenin decreases the activity of beta-catenin.	Arginine	47-55	catenin beta 1	Rattus norvegicus	109-121
35130601-12	2022	CONCLUSION: MG-132, a ubiquitin proteasome inhibitor, can regulate Wnt/beta-catenin signaling pathway by inhibiting the degradation of beta-catenin protein, and delaying the occurrence and development of osteoporosis.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	12-18	catenin beta 1	Rattus norvegicus	71-83
35130601-12	2022	CONCLUSION: MG-132, a ubiquitin proteasome inhibitor, can regulate Wnt/beta-catenin signaling pathway by inhibiting the degradation of beta-catenin protein, and delaying the occurrence and development of osteoporosis.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	12-18	catenin beta 1	Rattus norvegicus	135-147
34549301-3	2022	Therefore, we aimed to investigate the possible inhibitory effect of PA on renal Wnt/beta-catenin signalling in CKD.	Protactinium	69-71	catenin beta 1	Rattus norvegicus	85-97
35069210-6	2021	Oxidative stress caused by UUO is tightly associated with endoplasmic reticulum stress and mitochondrial dysfunction, leading to apoptotic cell death through Wnt3alpha/beta-catenin/GSK-3beta signaling; all of which were abolished by both dapagliflozin and specific RIP inhibitors (necrostatin-1 and GSK872).	uuo	27-30	catenin beta 1	Rattus norvegicus	168-180
35069210-6	2021	Oxidative stress caused by UUO is tightly associated with endoplasmic reticulum stress and mitochondrial dysfunction, leading to apoptotic cell death through Wnt3alpha/beta-catenin/GSK-3beta signaling; all of which were abolished by both dapagliflozin and specific RIP inhibitors (necrostatin-1 and GSK872).	dapagliflozin	238-251	catenin beta 1	Rattus norvegicus	168-180
35012644-0	2022	Modification of mesenchymal stem cells by HMGB1 promotes the activity of Cav3.2 T-type calcium channel via PKA/beta-catenin/gamma-cystathionase pathway.	Calcium	87-94	catenin beta 1	Rattus norvegicus	111-123
35012644-11	2022	Intercellular cAMP, PKA activity, phosphorylation of beta-catenin, and GSK3beta were investigated to reveal cAMP/PKA mediated beta-catenin activation.	Cyclic AMP	108-112	catenin beta 1	Rattus norvegicus	53-65
35012644-11	2022	Intercellular cAMP, PKA activity, phosphorylation of beta-catenin, and GSK3beta were investigated to reveal cAMP/PKA mediated beta-catenin activation.	Cyclic AMP	108-112	catenin beta 1	Rattus norvegicus	126-138
35012644-20	2022	Finally, cAMP/PKA was activated to phosphorylate beta-catenin at Ser657 and GSK3beta, enabling persisting activation of Wnt/beta-catenin signaling in MSC-H cells.	Cyclic AMP	9-13	catenin beta 1	Rattus norvegicus	49-61
35012644-20	2022	Finally, cAMP/PKA was activated to phosphorylate beta-catenin at Ser657 and GSK3beta, enabling persisting activation of Wnt/beta-catenin signaling in MSC-H cells.	Cyclic AMP	9-13	catenin beta 1	Rattus norvegicus	124-136
35012644-21	2022	CONCLUSION: Our study revealed that modification of MSCs with HMGB1 promoted CACNA1H-mediated calcium influx via PKA/beta-catenin/gamma-cystathionase pathway.	Calcium	94-101	catenin beta 1	Rattus norvegicus	117-129
35069210-8	2021	Moreover, activated Wnt3alpha/beta-catenin/GSK-3beta signaling was inhibited by dapagliflozin and Wnt/beta-catenin inhibitor ICG-001.	dapagliflozin	80-93	catenin beta 1	Rattus norvegicus	30-42
35069210-8	2021	Moreover, activated Wnt3alpha/beta-catenin/GSK-3beta signaling was inhibited by dapagliflozin and Wnt/beta-catenin inhibitor ICG-001.	ICG 001	125-132	catenin beta 1	Rattus norvegicus	30-42
35069210-8	2021	Moreover, activated Wnt3alpha/beta-catenin/GSK-3beta signaling was inhibited by dapagliflozin and Wnt/beta-catenin inhibitor ICG-001.	ICG 001	125-132	catenin beta 1	Rattus norvegicus	102-114
35069210-9	2021	Our findings suggest that dapagliflozin ameliorates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation via Wnt3alpha/beta-catenin/GSK-3beta signaling in UUO.	dapagliflozin	26-39	catenin beta 1	Rattus norvegicus	137-149
34549301-10	2022	CONCLUSIONS: These results suggest a new therapeutic benefit of PA in ameliorating CKD in rats through its up-regulatory effect on renal klotho thereby preventing Wnt/beta-catenin reactivation and RAS gene expression.	Protactinium	64-66	catenin beta 1	Rattus norvegicus	167-179
35282079-7	2022	Furthermore, both LY294002 (a PI3K inhibitor) and IWR-1 (a Wnt/beta-catenin inhibitor) inhibited the PBMT promotion of NSC proliferation after OGD and suppressed beta-catenin and cyclin D1 expression in vitro.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	catenin beta 1	Rattus norvegicus	162-174
35600648-5	2022	Based on bioinformatics analysis, here we investigated the effects of LINC00473 on the LRP5/Wnt/beta-catenin signaling pathway in the osteogenesis and adipogenesis of BMSCs, as well as the PEBP1/Akt/Bad/Bcl-2 signaling pathway in dexamethasone- (Dex-) induced apoptosis of BMSCs.	linc00473	70-79	catenin beta 1	Rattus norvegicus	96-108
35068466-10	2022	RESULTS: DNLA ameliorated Abeta-induced cognitive impairment, increased the number of synapses, elevated the postsynaptic density thickness and expression of synapsin and PSD95 in the hippocampus, and suppressed Abeta-mediated GSK3beta activity and the beta-catenin phosphorylation.	dnla	9-13	catenin beta 1	Rattus norvegicus	253-265
35068466-12	2022	Furthermore, the Wnt/beta-catenin pathway inhibitor Dkk-1 blocked the effect of DNLA on the expression of Abeta 1-42 and PSD95.	dnla	80-84	catenin beta 1	Rattus norvegicus	21-33
35068466-13	2022	CONCLUSION: DNLA rescued Abeta-mediated synaptic and mitochondrial injury and inhibited amyloidogenesis in vivo and in vitro, probably through the activation of Wnt/beta-catenin signaling pathway to protect synaptic integrity.	dnla	12-16	catenin beta 1	Rattus norvegicus	165-177
35600648-6	2022	Our data showed that LINC00473 could promote osteogenesis and suppress the adipogenesis of BMSCs through the activation of the miR-23a-3p/LRP5/Wnt/beta-catenin signaling pathway axis, while rescuing BMSCs from Dex-induced apoptosis by activating the miR-23a-3p/PEBP1/Akt/Bad/Bcl-2 signaling pathway axis.	linc00473	21-30	catenin beta 1	Rattus norvegicus	147-159