PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33915153-10	2021	Patients with frameshift mutations in ABCB11 gene (p.Thr127Hisfs*6) and ABCB4 gene (p.Phe210Serfs*5) had significantly shorter survival time than missense mutations (P = 0.011; P = .0039, respectively).	thr127hisfs	53-64	ATP binding cassette subfamily B member 11	Homo sapiens	38-44
33713832-3	2021	Mice deficient in the Bile Salt Export Pump (Bsep, or Abcb11), the primary bile acid transporter in liver cells, produce high levels of THBA, and avoid the severe liver damage typically seen in humans with BSEP deficiencies.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	206-210
34016879-2	2021	METHODS: Analyses included participants with pathogenic biallelic mutations in ABCB11 (bile salt export pump; BSEP) or ATP8B1 (familial intrahepatic cholestasis; FIC1), or those with monoallelic or biallelic mutations in ABCB4 (multidrug resistance; MDR3), prospectively enrolled in the Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC; NCT00571272) between 11/2007-12/2013.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	79-85
34016879-2	2021	METHODS: Analyses included participants with pathogenic biallelic mutations in ABCB11 (bile salt export pump; BSEP) or ATP8B1 (familial intrahepatic cholestasis; FIC1), or those with monoallelic or biallelic mutations in ABCB4 (multidrug resistance; MDR3), prospectively enrolled in the Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC; NCT00571272) between 11/2007-12/2013.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
32634627-13	2021	However, lower levels of BSEP in bile canaliculi in liver biopsies were associated with altered serum levels of bile acids.	Bile Acids and Salts	112-122	ATP binding cassette subfamily B member 11	Homo sapiens	25-29
32634627-15	2021	Reduced protein expression of BSEP in liver tissue, rather than variants of the ABCB11 gene were associated with altered serum levels of bile acids.	Bile Acids and Salts	137-147	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
33450190-1	2021	The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes.	Bile Acids and Salts	66-75	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
33472814-2	2021	We investigated the transport function of BSEP in SHH using a method involving in situ biosynthesis of bile salts from their precursor bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA).	Cholic Acid	147-158	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33472814-2	2021	We investigated the transport function of BSEP in SHH using a method involving in situ biosynthesis of bile salts from their precursor bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA).	Chenodeoxycholic Acid	168-189	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33472814-2	2021	We investigated the transport function of BSEP in SHH using a method involving in situ biosynthesis of bile salts from their precursor bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA).	Chenodeoxycholic Acid	191-195	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33472814-8	2021	The observed discrepancy in the IC50 was attributed to the fact that troglitazone also inhibits organic anion transporting polypeptide (OATP)s and Na+/ taurocholate co-transporting polypeptide (NTCP) in addition to BSEP.	Troglitazone	69-81	ATP binding cassette subfamily B member 11	Homo sapiens	215-219
33472814-10	2021	In summary, these data demonstrated the expression and function of BSEP and its major role in transport of bile salts in cryopreserved SHH.	Bile Acids and Salts	107-117	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
33472814-13	2021	The study also illustrated the major role of BSEP relative to basolateral MRP3 and MRP4 in transport of bile salts in SHH.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	45-49
33472814-14	2021	Understanding of BSEP function in SHH may bolster the utility of this platform in mechanistic understanding of bile salt disposition and potentially in the assessment of drugs for BSEP inhibition.	Bile Acids and Salts	111-120	ATP binding cassette subfamily B member 11	Homo sapiens	17-21
33502191-1	2021	Cholestatic liver injury is frequently associated with drug inhibition of bile salt transporters, such as the bile salt export pump (BSEP).	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	110-131
33502191-1	2021	Cholestatic liver injury is frequently associated with drug inhibition of bile salt transporters, such as the bile salt export pump (BSEP).	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	133-137
33472814-1	2021	The mechanistic understanding of bile salt disposition is not well established in suspension human hepatocytes (SHH) due to limited information on the expression and function of bile salt export protein (BSEP) in this system.	Bile Acids and Salts	178-187	ATP binding cassette subfamily B member 11	Homo sapiens	204-208
33472814-2	2021	We investigated the transport function of BSEP in SHH using a method involving in situ biosynthesis of bile salts from their precursor bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA).	Bile Acids and Salts	103-113	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33472814-2	2021	We investigated the transport function of BSEP in SHH using a method involving in situ biosynthesis of bile salts from their precursor bile acids, cholic acid (CA) and chenodeoxycholic acid (CDCA).	Bile Acids and Salts	135-145	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33750401-1	2021	BACKGROUND: The bile salt export pump (BSEP) is a pivotal apical/canalicular bile salt transporter in hepatocytes that drives the bile flow.	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
33622223-11	2021	Letermovir also inhibited OATP1B1/3, OATP2B1, OAT3, OCT2, BCRP, BSEP, and P-gp.	letermovir	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	64-68
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Bile Acids and Salts	42-52	ATP binding cassette subfamily B member 11	Homo sapiens	26-32
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Phosphatidylcholines	73-92	ATP binding cassette subfamily B member 11	Homo sapiens	26-32
33672718-2	2021	Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds.	Cholesterol	125-136	ATP binding cassette subfamily B member 11	Homo sapiens	26-32
33581308-1	2021	The bile salt export pump (BSEP/ABCB11) is located on the apical membrane and mediates the secretion of bile salts from hepatocytes into the bile.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
33581308-1	2021	The bile salt export pump (BSEP/ABCB11) is located on the apical membrane and mediates the secretion of bile salts from hepatocytes into the bile.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
33581308-1	2021	The bile salt export pump (BSEP/ABCB11) is located on the apical membrane and mediates the secretion of bile salts from hepatocytes into the bile.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	32-38
33581308-2	2021	BSEP-mediated bile salt efflux is the rate-limiting step of bile salt secretion and the main driving force of bile flow.	Bile Acids and Salts	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
33581308-2	2021	BSEP-mediated bile salt efflux is the rate-limiting step of bile salt secretion and the main driving force of bile flow.	Bile Acids and Salts	60-69	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
33581308-3	2021	BSEP drives and maintains the enterohepatic circulation of bile salts.	Bile Acids and Salts	59-69	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
33450190-1	2021	The bile salt export pump (BSEP) is responsible for the export of bile acid from hepatocytes.	Bile Acids and Salts	66-75	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
33450190-2	2021	Impaired transcellular transport of bile acids in hepatocytes with mutations in BSEP causes cholestasis.	Bile Acids and Salts	36-46	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
33450190-3	2021	Compensatory mechanisms to regulate the intracellular bile acid concentration in human hepatocytes with BSEP deficiency remain unclear.	Bile Acids and Salts	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33450190-6	2021	Modeling the autoregulation of bile acids on hepatocytes, we found that BSEP-deficient i-Heps suppressed de novo bile acid synthesis using the FXR pathway via basolateral uptake and export without apical export.	Bile Acids and Salts	31-41	ATP binding cassette subfamily B member 11	Homo sapiens	72-76
33450190-6	2021	Modeling the autoregulation of bile acids on hepatocytes, we found that BSEP-deficient i-Heps suppressed de novo bile acid synthesis using the FXR pathway via basolateral uptake and export without apical export.	Bile Acids and Salts	31-40	ATP binding cassette subfamily B member 11	Homo sapiens	72-76
33450190-7	2021	These observations inform the development of therapeutic targets to reduce the overall bile acid pool in patients with BSEP deficiency.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	119-123
33039464-9	2021	The accumulation of fluorescent bile acid into organoid was impaired by CRISPR-Cas9 based gene editing and transporter inhibitor treatment of BSEP.	Bile Acids and Salts	32-41	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
33546617-11	2021	We classified these loci into four groups (the damaging, probably damaging, possibly damaging, and neutral groups) according to the prediction results, of which 7 novel possible pathogenic mutations were identified that were located in known functional genes, including ABCB4 (Trp708Ter, Gly527Glu and Lys386Glu), ABCB11 (Gln1194Ter, Gln605Pro and Leu589Met) and ABCC2 (Ser1342Tyr), in the damaging group.	gln1194ter	322-332	ATP binding cassette subfamily B member 11	Homo sapiens	314-320
33893772-6	2021	Compared with the control group, the expression levels of OB-Rb, p-AMPKa2, and BSEP decreased significantly in the GS and PIBDS groups.	pibds	122-127	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
33466755-1	2021	The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	76-86	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
33466755-1	2021	The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	76-86	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
33466755-1	2021	The bile salt export pump (BSEP/ABCB11) is responsible for the transport of bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	76-86	ATP binding cassette subfamily B member 11	Homo sapiens	32-38
33553369-0	2021	Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial Hypercholesterolemia: a case report.	Rosuvastatin Calcium	17-29	ATP binding cassette subfamily B member 11	Homo sapiens	82-88
33159914-0	2021	Transient, tunable expression of NTCP and BSEP in MDCKII cells for kinetic delineation of the rate-determining process and inhibitory effects of rifampicin in hepatobiliary transport of taurocholate.	Taurocholic Acid	186-198	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
33159914-4	2021	The biliary excretion clearance for taurocholate increased proportionally to the BSEP expression level.	Taurocholic Acid	36-48	ATP binding cassette subfamily B member 11	Homo sapiens	81-85
33159914-6	2021	The doubly transfected MDCKII cells were also used to kinetically analyze the inhibitory effects of rifampicin on BSEP and NTCP.	Rifampin	100-110	ATP binding cassette subfamily B member 11	Homo sapiens	114-118
33868646-3	2020	Therefore, we chose to target the AAVS1 site for the insertion of ABCB11, a bile acid transporter which is defective in progressive familial intra hepatic cholestasis type-2 (PFIC-2), a lethal disease of children where cytotoxic bile salts accumulate inside hepatocytes killing them and eventually the patient.	Bile Acids and Salts	229-239	ATP binding cassette subfamily B member 11	Homo sapiens	66-72
33383947-2	2020	Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3.	Bile Acids and Salts	99-108	ATP binding cassette subfamily B member 11	Homo sapiens	91-97
33383947-2	2020	Six types have been reported, two of these are caused by deficiency of an ABC transporter; ABCB11 (bile salt export pump) in type 2; ABCB4 (phosphatidylcholine floppase) in type 3.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 11	Homo sapiens	91-97
33868646-3	2020	Therefore, we chose to target the AAVS1 site for the insertion of ABCB11, a bile acid transporter which is defective in progressive familial intra hepatic cholestasis type-2 (PFIC-2), a lethal disease of children where cytotoxic bile salts accumulate inside hepatocytes killing them and eventually the patient.	Bile Acids and Salts	229-239	ATP binding cassette subfamily B member 11	Homo sapiens	175-181
33314224-1	2021	Amzal and colleagues (1) reported about the prospect of pharmacological premature termination codon (PMT) readthrough of ABCB11 mRNA in bile salt export pump deficiency, the latter causing progressive familial intrahepatic cholestasis (PFIC)-type 2.	Bile Acids and Salts	136-145	ATP binding cassette subfamily B member 11	Homo sapiens	121-127
33314224-2	2021	The authors demonstrate that aminoglycoside antibiotics can stimulate readthrough of nonsense mutation-induced PMT in the ABCB11 mRNA, thereby rescuing full-length ABCB11 protein synthesis.	Aminoglycosides	29-43	ATP binding cassette subfamily B member 11	Homo sapiens	122-128
33314224-2	2021	The authors demonstrate that aminoglycoside antibiotics can stimulate readthrough of nonsense mutation-induced PMT in the ABCB11 mRNA, thereby rescuing full-length ABCB11 protein synthesis.	Aminoglycosides	29-43	ATP binding cassette subfamily B member 11	Homo sapiens	164-170
32646411-3	2020	Despite variants of bile salt (BS) export pump (BSEP/ABCB11) have already been described in TNC, the pathogenic role of BSEP dysfunction in TNC remained so far elusive.	Bile Acids and Salts	20-29	ATP binding cassette subfamily B member 11	Homo sapiens	48-52
33998860-12	2020	Tweed Argyle also inhibited ABCB11 transporter function with an IC50 value of 11.9 muM for CBD and 7.7 muM for Delta9-THC.	Cannabidiol	91-94	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
33998860-12	2020	Tweed Argyle also inhibited ABCB11 transporter function with an IC50 value of 11.9 muM for CBD and 7.7 muM for Delta9-THC.	delta9	111-117	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
33998860-12	2020	Tweed Argyle also inhibited ABCB11 transporter function with an IC50 value of 11.9 muM for CBD and 7.7 muM for Delta9-THC.	Dronabinol	118-121	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
32433800-0	2020	Functional rescue of an ABCB11 mutant by ivacaftor: a new targeted pharmacotherapy approach in bile salt export pump deficiency.	ivacaftor	41-50	ATP binding cassette subfamily B member 11	Homo sapiens	24-30
32433800-0	2020	Functional rescue of an ABCB11 mutant by ivacaftor: a new targeted pharmacotherapy approach in bile salt export pump deficiency.	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	24-30
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Bile Acids and Salts	34-43	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Bile Acids and Salts	34-43	ATP binding cassette subfamily B member 11	Homo sapiens	62-68
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Adenosine	97-106	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Adenosine	97-106	ATP binding cassette subfamily B member 11	Homo sapiens	62-68
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Bile Acids and Salts	177-186	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
32433800-1	2020	BACKGROUND & AIM: The canalicular bile salt export pump (BSEP/ABCB11) of hepatocytes is the main adenosine triphosphate (ATP)-binding cassette (ABC) transporter responsible for bile acid secretion.	Bile Acids and Salts	177-186	ATP binding cassette subfamily B member 11	Homo sapiens	62-68
32433800-3	2020	We investigated in vitro the effect and potential rescue of a BSEP mutation by ivacaftor, a clinically approved cystic fibrosis transmembrane conductance regulator (CFTR/ABCC7) potentiator.	ivacaftor	79-88	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
32433800-12	2020	CONCLUSION: These results provide experimental evidence of ivacaftor therapeutic potential for selected patients with PFIC2 caused by ABCB11 missense mutations affecting BSEP function.	ivacaftor	59-68	ATP binding cassette subfamily B member 11	Homo sapiens	118-123
32433800-12	2020	CONCLUSION: These results provide experimental evidence of ivacaftor therapeutic potential for selected patients with PFIC2 caused by ABCB11 missense mutations affecting BSEP function.	ivacaftor	59-68	ATP binding cassette subfamily B member 11	Homo sapiens	134-140
32433800-12	2020	CONCLUSION: These results provide experimental evidence of ivacaftor therapeutic potential for selected patients with PFIC2 caused by ABCB11 missense mutations affecting BSEP function.	ivacaftor	59-68	ATP binding cassette subfamily B member 11	Homo sapiens	170-174
32943412-1	2020	Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug induced liver injury (DILI).	Bile Acids and Salts	31-41	ATP binding cassette subfamily B member 11	Homo sapiens	59-80
32943412-1	2020	Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug induced liver injury (DILI).	Bile Acids and Salts	31-41	ATP binding cassette subfamily B member 11	Homo sapiens	82-86
32943412-1	2020	Hepatocellular accumulation of bile salts by inhibition of bile salt export pump (BSEP/ABCB11) may result in cholestasis and is one proposed mechanism of drug induced liver injury (DILI).	Bile Acids and Salts	31-41	ATP binding cassette subfamily B member 11	Homo sapiens	87-93
32943412-10	2020	A two-tiered strategy incorporating MPCCs is presented to reduce BSEP inhibition potential and improve DILI risk.	mpccs	36-41	ATP binding cassette subfamily B member 11	Homo sapiens	65-69
32646411-3	2020	Despite variants of bile salt (BS) export pump (BSEP/ABCB11) have already been described in TNC, the pathogenic role of BSEP dysfunction in TNC remained so far elusive.	Bile Acids and Salts	20-29	ATP binding cassette subfamily B member 11	Homo sapiens	53-59
32646411-4	2020	CASE PRESENTATION: We report on a newly-identified heterozygous ABCB11 missense variant (c.1345G > A, p.Glu449Lys) which was associated with prolonged cholestasis in a term infant after a complicated neonatal period.	glu449lys	104-113	ATP binding cassette subfamily B member 11	Homo sapiens	64-70
32565027-7	2020	Evidence on bile acid metabolism supports our identification of associations between the Bile Salt Export Pump and renal, thyroid, lipid metabolism, respiratory tract and central nervous system disorders.	Bile Acids and Salts	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	89-110
32203132-0	2020	Cryo-EM structure of human bile salts exporter ABCB11.	Bile Acids and Salts	27-37	ATP binding cassette subfamily B member 11	Homo sapiens	47-53
32309332-0	2020	Changes in plasma bile acid profiles after partial internal biliary diversion in PFIC2 patients.	Bile Acids and Salts	18-27	ATP binding cassette subfamily B member 11	Homo sapiens	81-86
32087350-1	2020	BACKGROUND & AIMS: Mutations in ABCB11 can cause deficiency of the bile salt export pump (BSEP), leading to cholestasis and end-stage liver disease.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	36-42
32087350-1	2020	BACKGROUND & AIMS: Mutations in ABCB11 can cause deficiency of the bile salt export pump (BSEP), leading to cholestasis and end-stage liver disease.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	71-92
32087350-1	2020	BACKGROUND & AIMS: Mutations in ABCB11 can cause deficiency of the bile salt export pump (BSEP), leading to cholestasis and end-stage liver disease.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	94-98
32242141-4	2020	Unlike TUDC, 24-nor-ursodeoxycholic acid (norUDCA)-induced beta1 integrin activation triggered only transient activation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase and, consequently, only transient insertion of the bile acid transporter Bsep into the canalicular membrane, and did not involve activation of epidermal growth factor receptor.	24-norursodeoxycholic acid	13-40	ATP binding cassette subfamily B member 11	Homo sapiens	277-281
32242141-4	2020	Unlike TUDC, 24-nor-ursodeoxycholic acid (norUDCA)-induced beta1 integrin activation triggered only transient activation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase and, consequently, only transient insertion of the bile acid transporter Bsep into the canalicular membrane, and did not involve activation of epidermal growth factor receptor.	24-norursodeoxycholic acid	42-49	ATP binding cassette subfamily B member 11	Homo sapiens	277-281
32309332-2	2020	Methods: Plasma bile acids were profiled in 3 cases of ATP-binding cassette, sub-family B member 11 (ABCB11)-mutated PFIC2 children before and after PIBD compared to healthy controls and 8 PFIC2 patients.	Bile Acids and Salts	16-26	ATP binding cassette subfamily B member 11	Homo sapiens	55-99
32309332-2	2020	Methods: Plasma bile acids were profiled in 3 cases of ATP-binding cassette, sub-family B member 11 (ABCB11)-mutated PFIC2 children before and after PIBD compared to healthy controls and 8 PFIC2 patients.	Bile Acids and Salts	16-26	ATP binding cassette subfamily B member 11	Homo sapiens	101-107
32309332-2	2020	Methods: Plasma bile acids were profiled in 3 cases of ATP-binding cassette, sub-family B member 11 (ABCB11)-mutated PFIC2 children before and after PIBD compared to healthy controls and 8 PFIC2 patients.	Bile Acids and Salts	16-26	ATP binding cassette subfamily B member 11	Homo sapiens	117-122
31907698-0	2020	Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.	Metformin	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	50-71
31894354-7	2020	Moreover, as low as 0.01 muM EPI upregulated the expression of key BA synthesis genes (CYP7A1, by 65% and CYP8B1, by 67%) and BA transporters (NTCP, OSTA and BSEP), and downregulated FGF19.	epi	29-32	ATP binding cassette subfamily B member 11	Homo sapiens	158-162
31907698-0	2020	Metformin Disrupts Bile Acid Efflux by Repressing Bile Salt Export Pump Expression.	Bile Acids and Salts	19-28	ATP binding cassette subfamily B member 11	Homo sapiens	50-71
31907698-1	2020	PURPOSE: The bile salt export pump (BSEP), a key player in hepatic bile acid clearance, has been the center of research on drug-induced cholestasis.	Bile Acids and Salts	67-76	ATP binding cassette subfamily B member 11	Homo sapiens	13-34
31907698-1	2020	PURPOSE: The bile salt export pump (BSEP), a key player in hepatic bile acid clearance, has been the center of research on drug-induced cholestasis.	Bile Acids and Salts	67-76	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
31907698-3	2020	This work aims to explore the disruption of bile acid efflux caused by drug-induced BSEP repression.	Bile Acids and Salts	44-53	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
31907698-6	2020	RESULTS: Metformin concentration-dependently repressed BSEP expression in HPH.	Metformin	9-18	ATP binding cassette subfamily B member 11	Homo sapiens	55-59
31907698-7	2020	Although metformin did not directly inhibit BSEP activity, longer metformin exposure reduced BSEP transport function in HPH by down-regulating BSEP expression.	Metformin	66-75	ATP binding cassette subfamily B member 11	Homo sapiens	93-97
31907698-7	2020	Although metformin did not directly inhibit BSEP activity, longer metformin exposure reduced BSEP transport function in HPH by down-regulating BSEP expression.	Metformin	66-75	ATP binding cassette subfamily B member 11	Homo sapiens	93-97
31907698-8	2020	BSEP repression by metformin was found to be AMP-activated protein kinase-independent.	Metformin	19-28	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
31907698-9	2020	Additional screening of 10 reported cholestatic non-BSEP inhibitors revealed that the anti-cancer drug tamoxifen also markedly repressed BSEP expression and reduced BSEP activity in HPH.	Tamoxifen	103-112	ATP binding cassette subfamily B member 11	Homo sapiens	52-56
31907698-9	2020	Additional screening of 10 reported cholestatic non-BSEP inhibitors revealed that the anti-cancer drug tamoxifen also markedly repressed BSEP expression and reduced BSEP activity in HPH.	Tamoxifen	103-112	ATP binding cassette subfamily B member 11	Homo sapiens	137-141
31907698-9	2020	Additional screening of 10 reported cholestatic non-BSEP inhibitors revealed that the anti-cancer drug tamoxifen also markedly repressed BSEP expression and reduced BSEP activity in HPH.	Tamoxifen	103-112	ATP binding cassette subfamily B member 11	Homo sapiens	137-141
31907698-10	2020	CONCLUSIONS: Repression of BSEP alone is sufficient to disrupt hepatic bile acid efflux.	Bile Acids and Salts	71-80	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
31907698-11	2020	Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition.	Metformin	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
31907698-11	2020	Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition.	Metformin	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	160-164
31907698-11	2020	Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition.	Tamoxifen	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
31907698-11	2020	Metformin and tamoxifen appear to be prototypes of a class of BSEP repressors that may cause drug-induced cholestasis through gene repression instead of direct BSEP inhibition.	Tamoxifen	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	160-164
31571363-11	2020	TAN IIA induced the expression of ten-eleven translocation 2 (TET2) to mediate the demethylation of NRF2, which promoted NRF2 DNA-binding on the BSEP and NTCP promoters and their transcriptional activation.	Triacetoneamine-N-Oxyl	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
31810127-1	2020	PURPOSE: This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in ribavirin (RBV) transport (SLC28A2 gene, ABCB1 gene and ABCB11 gene) on the clinical outcome and pharmacokinetics of ribavirin in HCV- 4 Egyptian patients.	Ribavirin	115-124	ATP binding cassette subfamily B member 11	Homo sapiens	171-177
31810127-1	2020	PURPOSE: This study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) of genes involved in ribavirin (RBV) transport (SLC28A2 gene, ABCB1 gene and ABCB11 gene) on the clinical outcome and pharmacokinetics of ribavirin in HCV- 4 Egyptian patients.	Ribavirin	126-129	ATP binding cassette subfamily B member 11	Homo sapiens	171-177
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	123-132	ATP binding cassette subfamily B member 11	Homo sapiens	41-47
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	123-132	ATP binding cassette subfamily B member 11	Homo sapiens	210-216
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	123-132	ATP binding cassette subfamily B member 11	Homo sapiens	210-216
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	227-236	ATP binding cassette subfamily B member 11	Homo sapiens	41-47
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	227-236	ATP binding cassette subfamily B member 11	Homo sapiens	210-216
31810127-9	2020	CONCLUSION: SNP genotyping for ABCB1 and ABCB11 genes can help in better personalized medicine for maximizing response for ribavirin as explored by the significant association between polymorphism in ABCB1 and ABCB11 genes and ribavirin pharmacokinetics and the significant association of ABCB11 1331 T > C SNP with clinical response.	Ribavirin	227-236	ATP binding cassette subfamily B member 11	Homo sapiens	210-216
31571363-0	2020	Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.	tanshinone	0-14	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
31571363-0	2020	Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.	Rifampin	24-34	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
31394163-2	2019	Cholestatic DILI is characterized by bile acid (BA) accumulation in hepatocytes, typically caused by drug-induced inhibition of important bile transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4).	Bile Acids and Salts	37-46	ATP binding cassette subfamily B member 11	Homo sapiens	165-186
31571363-2	2020	Bile salt efflux pump (BSEP) and Na+/taurocholate cotransporter (NTCP) are the major BA transporters.	Bile Acids and Salts	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
31571363-2	2020	Bile salt efflux pump (BSEP) and Na+/taurocholate cotransporter (NTCP) are the major BA transporters.	Bile Acids and Salts	85-87	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
31571363-6	2020	RESULTS: TAN IIA strongly induced BSEP and NTCP expression in hepatocytes.	tanshinone	9-16	ATP binding cassette subfamily B member 11	Homo sapiens	34-38
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Phosphatidylcholines	203-222	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Bile Acids and Salts	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
31886153-2	2019	ABCB11, the bile salt efflux pump of hepatocytes, coordinates cellular excretion of numerous conjugated bile salts into the bile canaliculi, whereas ABCB4 acts as an ATP-dependent floppase translocating phosphatidylcholine from the inner to the outer leaflet of the bile canalicular membrane.	Adenosine Triphosphate	166-169	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
31394163-2	2019	Cholestatic DILI is characterized by bile acid (BA) accumulation in hepatocytes, typically caused by drug-induced inhibition of important bile transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4).	Bile Acids and Salts	37-46	ATP binding cassette subfamily B member 11	Homo sapiens	188-192
31394163-2	2019	Cholestatic DILI is characterized by bile acid (BA) accumulation in hepatocytes, typically caused by drug-induced inhibition of important bile transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4).	Bile Acids and Salts	48-50	ATP binding cassette subfamily B member 11	Homo sapiens	165-186
31394163-2	2019	Cholestatic DILI is characterized by bile acid (BA) accumulation in hepatocytes, typically caused by drug-induced inhibition of important bile transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4).	Bile Acids and Salts	48-50	ATP binding cassette subfamily B member 11	Homo sapiens	188-192
31348918-4	2019	It is thus likely that MC congeners will also differ with respect to the cellular efflux of the parent and conjugated congeners, e.g. via MRPs, MDRs, BCRP or BSEP.	microcystin	23-25	ATP binding cassette subfamily B member 11	Homo sapiens	158-162
32153769-6	2019	RT-qPCR and western blotting were performed to examine the mRNA and protein expression, respectively, of the classic bile acid synthetic pathway gene CYP7A1, the bile acid efflux transporter bile salt export pump (BSEP), the nuclear factor erythroid-2-related factor 2 (Nrf2) and the drug processing gene CYP1A2.	Bile Acids and Salts	117-126	ATP binding cassette subfamily B member 11	Homo sapiens	214-218
31538484-1	2019	BACKGROUND AND AIMS: heterozygous ABCB4, ABCB11 and ATP8B1 sequence variants were previously reported to be associated with low phospholipid-associated cholelithiasis, intrahepatic cholestasis of pregnancy, benign recurrent intrahepatic cholestasis and biliary lithiasis.	Phospholipids	128-140	ATP binding cassette subfamily B member 11	Homo sapiens	41-47
31611804-9	2019	We analysed BA levels in various tissues of Benign Recurrent Intrahepatic Cholestasis type 2 (BRIC2) patients and our simulations suggest a higher susceptibility of BRIC2 patients toward cholestatic DILI due to BA accumulation in the liver.	Bile Acids and Salts	12-14	ATP binding cassette subfamily B member 11	Homo sapiens	44-92
31611804-9	2019	We analysed BA levels in various tissues of Benign Recurrent Intrahepatic Cholestasis type 2 (BRIC2) patients and our simulations suggest a higher susceptibility of BRIC2 patients toward cholestatic DILI due to BA accumulation in the liver.	Bile Acids and Salts	12-14	ATP binding cassette subfamily B member 11	Homo sapiens	94-99
31611804-9	2019	We analysed BA levels in various tissues of Benign Recurrent Intrahepatic Cholestasis type 2 (BRIC2) patients and our simulations suggest a higher susceptibility of BRIC2 patients toward cholestatic DILI due to BA accumulation in the liver.	Bile Acids and Salts	12-14	ATP binding cassette subfamily B member 11	Homo sapiens	165-170
31611804-9	2019	We analysed BA levels in various tissues of Benign Recurrent Intrahepatic Cholestasis type 2 (BRIC2) patients and our simulations suggest a higher susceptibility of BRIC2 patients toward cholestatic DILI due to BA accumulation in the liver.	Bile Acids and Salts	211-213	ATP binding cassette subfamily B member 11	Homo sapiens	165-170
31611804-11	2019	Our results confirmed the higher risk of DILI after CsA administration in healthy and BRIC2 patients.	Cyclosporine	52-55	ATP binding cassette subfamily B member 11	Homo sapiens	86-91
32153769-6	2019	RT-qPCR and western blotting were performed to examine the mRNA and protein expression, respectively, of the classic bile acid synthetic pathway gene CYP7A1, the bile acid efflux transporter bile salt export pump (BSEP), the nuclear factor erythroid-2-related factor 2 (Nrf2) and the drug processing gene CYP1A2.	Bile Acids and Salts	162-171	ATP binding cassette subfamily B member 11	Homo sapiens	191-212
32153769-6	2019	RT-qPCR and western blotting were performed to examine the mRNA and protein expression, respectively, of the classic bile acid synthetic pathway gene CYP7A1, the bile acid efflux transporter bile salt export pump (BSEP), the nuclear factor erythroid-2-related factor 2 (Nrf2) and the drug processing gene CYP1A2.	Bile Acids and Salts	162-171	ATP binding cassette subfamily B member 11	Homo sapiens	214-218
31371422-7	2019	DEX treatment resulted in more elongated and branched canaliculi and restored canalicular expression and function of BSEP.	Dexamethasone	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	117-121
31348918-5	2019	Consequently, the role and kinetics of different human efflux transporters - MRP, MDR, BCRP and BSEP in MC efflux was studied using insect membrane vesicles overexpressing the human transporters of interest.	microcystin	104-106	ATP binding cassette subfamily B member 11	Homo sapiens	96-100
31091858-8	2019	Immunostaining showed total loss of bile salt export pump in two patients with PFIC2 and focal loss in two.	Bile Acids and Salts	36-45	ATP binding cassette subfamily B member 11	Homo sapiens	79-84
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Plicamycin	3-14	ATP binding cassette subfamily B member 11	Homo sapiens	135-141
31285099-2	2019	Its underlying mechanisms are dysfunction of bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4), which play major roles in bile acid (BA) excretion into the bile canaliculi and blood, resulting in accumulation of BAs in hepatocytes.	Bile Acids and Salts	162-171	ATP binding cassette subfamily B member 11	Homo sapiens	45-66
31285099-2	2019	Its underlying mechanisms are dysfunction of bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4), which play major roles in bile acid (BA) excretion into the bile canaliculi and blood, resulting in accumulation of BAs in hepatocytes.	Bile Acids and Salts	162-171	ATP binding cassette subfamily B member 11	Homo sapiens	68-72
31285099-2	2019	Its underlying mechanisms are dysfunction of bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4), which play major roles in bile acid (BA) excretion into the bile canaliculi and blood, resulting in accumulation of BAs in hepatocytes.	Bile Acids and Salts	173-175	ATP binding cassette subfamily B member 11	Homo sapiens	45-66
31285099-2	2019	Its underlying mechanisms are dysfunction of bile salt export pump (BSEP) and multidrug resistance-associated protein 2/3/4 (MRP2/3/4), which play major roles in bile acid (BA) excretion into the bile canaliculi and blood, resulting in accumulation of BAs in hepatocytes.	Bile Acids and Salts	173-175	ATP binding cassette subfamily B member 11	Homo sapiens	68-72
31285099-5	2019	Fluorescent N-(24-[7-(4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole)]amino-3alpha,7alpha,12alpha-trihydroxy-27-nor-5beta-cholestan-26-oyl)-2"-aminoethanesulfonate (tauro-nor-THCA-24-DBD, a BSEP substrate) was accumulated in bile canaliculi, which supports the presence of a functional bile canaliculi lumen.	tauro-nor-thca-24-dbd	167-188	ATP binding cassette subfamily B member 11	Homo sapiens	192-196
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Plicamycin	3-14	ATP binding cassette subfamily B member 11	Homo sapiens	274-278
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Bile Acids and Salts	44-53	ATP binding cassette subfamily B member 11	Homo sapiens	135-141
31175181-5	2019	As mithramycin affects cellular response to bile acid treatment by altering the expression of multiple bile transporters (e.g., ABCB4, ABCB11, sodium/taurocholate cotransporting polypeptide, organic solute transporter alpha/beta) in several cell lines [Huh7, HepaRG, HepaRG BSEP (-/-)] and primary human hepatocytes, we hypothesized that mithramycin inhibited bile-mediated activation of the farnesoid X receptor (FXR).	Bile Acids and Salts	44-53	ATP binding cassette subfamily B member 11	Homo sapiens	274-278
31175181-7	2019	Mithramycin promoted glycochenodeoxycholic acid-induced cytotoxicity in ABCB11 (-/-) cells and increased the overall intracellular concentration of bile acids in primary human hepatocytes grown in sandwich culture (P < 0.01).	Plicamycin	0-11	ATP binding cassette subfamily B member 11	Homo sapiens	72-78
31175181-7	2019	Mithramycin promoted glycochenodeoxycholic acid-induced cytotoxicity in ABCB11 (-/-) cells and increased the overall intracellular concentration of bile acids in primary human hepatocytes grown in sandwich culture (P < 0.01).	Glycochenodeoxycholic Acid	21-47	ATP binding cassette subfamily B member 11	Homo sapiens	72-78
31175181-8	2019	Mithramycin is a FXR expression and FXR transactivation inhibitor that inhibits bile flow and potentiates bile-induced cellular toxicity, particularly in cells with low ABCB11 function.	Plicamycin	0-11	ATP binding cassette subfamily B member 11	Homo sapiens	169-175
31015375-7	2019	The entire coding region of ABCB11, encoding bile salt export pump, was analyzed.	Bile Acids and Salts	45-54	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
31341876-2	2019	ABCB11 encodes the bile salt export pump and this gene is mutated in several forms of intrahepatic cholestasis.	Bile Acids and Salts	19-28	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
30100615-5	2019	Variants showing significant association with rosuvastatin exposure were identified in SLCO1B1, ABCC2, SLC10A2, ABCB11, AHR, HNF4A, RXRA and FOXA3, and appear to be African specific.	Rosuvastatin Calcium	46-58	ATP binding cassette subfamily B member 11	Homo sapiens	112-118
30639138-6	2019	Assays in transporter-overexpressing membrane vesicles revealed that kynurenic acid inhibited TCA transport via the bile salt efflux pump (BSEP), whereas p-cresyl glucuronide and hippuric acid increased TCA efflux via multidrug resistance-associated protein 3 (MRP3).	Kynurenic Acid	69-83	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
30639138-6	2019	Assays in transporter-overexpressing membrane vesicles revealed that kynurenic acid inhibited TCA transport via the bile salt efflux pump (BSEP), whereas p-cresyl glucuronide and hippuric acid increased TCA efflux via multidrug resistance-associated protein 3 (MRP3).	Taurocholic Acid	94-97	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
30608704-0	2019	Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications.	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	52-73
30639138-6	2019	Assays in transporter-overexpressing membrane vesicles revealed that kynurenic acid inhibited TCA transport via the bile salt efflux pump (BSEP), whereas p-cresyl glucuronide and hippuric acid increased TCA efflux via multidrug resistance-associated protein 3 (MRP3).	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
30608704-1	2019	The bile salt export pump (BSEP) is the primary canalicular transporter responsible for the secretion of bile acids from hepatocytes into bile canaliculi, and inhibition of this transporter has been associated with drug-induced liver injury (DILI).	Bile Acids and Salts	105-115	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
30608704-1	2019	The bile salt export pump (BSEP) is the primary canalicular transporter responsible for the secretion of bile acids from hepatocytes into bile canaliculi, and inhibition of this transporter has been associated with drug-induced liver injury (DILI).	Bile Acids and Salts	105-115	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
31016647-2	2019	The bile salt export pump (BSEP; ABCB11) is of major importance for efflux of bile salts to the bile and BSEP inhibition frequently provokes drug-induced cholestasis.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
30517764-8	2019	The major SC constituents, in particular three anthraquinones, are able to activate AMPK in HepG2 cells and inhibit Bsep in primary mouse hepatocytes, with emodin showing the strongest activities.	Anthraquinones	47-61	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
30784208-3	2019	Mechanistic studies showed PF-04895162 had low cytotoxic potential in human hepatocytes, but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport.	pyrazofurin	27-29	ATP binding cassette subfamily B member 11	Homo sapiens	162-166
30784208-7	2019	Based on the affinity of conjugated bile acid species for transport by BSEP, the profile of plasma conjugated/unconjugated bile acid species was consistent with inhibition of BSEP.	Bile Acids and Salts	36-45	ATP binding cassette subfamily B member 11	Homo sapiens	71-75
30784208-7	2019	Based on the affinity of conjugated bile acid species for transport by BSEP, the profile of plasma conjugated/unconjugated bile acid species was consistent with inhibition of BSEP.	Bile Acids and Salts	36-45	ATP binding cassette subfamily B member 11	Homo sapiens	175-179
30784208-7	2019	Based on the affinity of conjugated bile acid species for transport by BSEP, the profile of plasma conjugated/unconjugated bile acid species was consistent with inhibition of BSEP.	Bile Acids and Salts	123-132	ATP binding cassette subfamily B member 11	Homo sapiens	175-179
30784208-9	2019	Alterations in systemic bile acid composition were more important than total bile acids in the manifestation of clinical liver injury and may be a very early biomarker of BSEP inhibition.	Bile Acids and Salts	24-33	ATP binding cassette subfamily B member 11	Homo sapiens	171-175
30289550-4	2019	Experimental data indicated that human bile salt export pump (BSEP) inhibition by TAK-875 was mixed whereas sodium taurocholate co-transporting polypeptide (NTCP) inhibition by TAK-875 was competitive.	TAK-875	82-89	ATP binding cassette subfamily B member 11	Homo sapiens	39-60
30289550-4	2019	Experimental data indicated that human bile salt export pump (BSEP) inhibition by TAK-875 was mixed whereas sodium taurocholate co-transporting polypeptide (NTCP) inhibition by TAK-875 was competitive.	TAK-875	82-89	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
30930437-5	2019	The ATP-binding cassette (ABC) transporter family members, ABCB11, ABCB4 and ABCG5/ABCG8, mediate the biliary secretion of bile salts, phospholipids and cholesterol, respectively.	Bile Acids and Salts	123-133	ATP binding cassette subfamily B member 11	Homo sapiens	59-65
30930437-5	2019	The ATP-binding cassette (ABC) transporter family members, ABCB11, ABCB4 and ABCG5/ABCG8, mediate the biliary secretion of bile salts, phospholipids and cholesterol, respectively.	Phospholipids	135-148	ATP binding cassette subfamily B member 11	Homo sapiens	59-65
30930437-5	2019	The ATP-binding cassette (ABC) transporter family members, ABCB11, ABCB4 and ABCG5/ABCG8, mediate the biliary secretion of bile salts, phospholipids and cholesterol, respectively.	Cholesterol	153-164	ATP binding cassette subfamily B member 11	Homo sapiens	59-65
31258056-1	2019	BACKGROUND: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts.	Taurocholic Acid	12-31	ATP binding cassette subfamily B member 11	Homo sapiens	71-92
31258056-1	2019	BACKGROUND: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts.	Taurocholic Acid	12-31	ATP binding cassette subfamily B member 11	Homo sapiens	94-98
31258056-1	2019	BACKGROUND: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts.	Bile Acids and Salts	210-220	ATP binding cassette subfamily B member 11	Homo sapiens	71-92
31258056-1	2019	BACKGROUND: Sodium Taurocholate Co-transporting Polypeptide (NTCP) and Bile Salt Export Pump (BSEP) play significant roles as membrane transporters because of their presence in the enterohepatic circulation of bile salts.	Bile Acids and Salts	210-220	ATP binding cassette subfamily B member 11	Homo sapiens	94-98
31258056-5	2019	CONCLUSION: NTCP and BSEP are important proteins for transportation and homeostasis maintenance of bile acids.	Bile Acids and Salts	99-109	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
31016647-5	2019	The cholestasis potential of compounds can be determined by specifically investigating the ability to inhibit BSEP-mediated uptake of tauro-nor-THCA-24-DBD, a fluorescent bile salt derivative.	tauro-nor-thca-24-dbd	134-155	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
31016647-5	2019	The cholestasis potential of compounds can be determined by specifically investigating the ability to inhibit BSEP-mediated uptake of tauro-nor-THCA-24-DBD, a fluorescent bile salt derivative.	Bile Acids and Salts	171-180	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
31016647-2	2019	The bile salt export pump (BSEP; ABCB11) is of major importance for efflux of bile salts to the bile and BSEP inhibition frequently provokes drug-induced cholestasis.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
31016647-2	2019	The bile salt export pump (BSEP; ABCB11) is of major importance for efflux of bile salts to the bile and BSEP inhibition frequently provokes drug-induced cholestasis.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
31016647-2	2019	The bile salt export pump (BSEP; ABCB11) is of major importance for efflux of bile salts to the bile and BSEP inhibition frequently provokes drug-induced cholestasis.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	105-109
31016647-3	2019	This chapter describes two assays to determine inhibition of BSEP-mediated bile salt excretion.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	61-65
29791258-8	2018	Additionally, triptolide decreased the mRNA and protein levels of Nrf2 and down-regulated Nrf2 target genes, including UGT1A, BSEP, and MRP2, while pretreatment with LE and MIG reversed these effects.	triptolide	14-24	ATP binding cassette subfamily B member 11	Homo sapiens	126-130
30431138-2	2019	Therefore, the aim of the present study was to investigate the association between ABCB11 gene mutation and primary intrahepatic stone (PIS)s and to investigate the mechanism through which ABCB11 gene mutations affect the expression of the corresponding protein.	Monothiopyrophosphoric acid	136-139	ATP binding cassette subfamily B member 11	Homo sapiens	83-89
30431138-3	2019	Mutations of the ABCB11 gene in 443 PIS patients and 560 healthy participants were detected by exon sequencing.	Monothiopyrophosphoric acid	36-39	ATP binding cassette subfamily B member 11	Homo sapiens	17-23
29412511-9	2018	Secondary bile acids were detected in patients without BSEP expression, suggesting biliary bile acid secretion through alternative routes.	Bile Acids and Salts	10-20	ATP binding cassette subfamily B member 11	Homo sapiens	55-59
29908072-6	2018	KEY RESULTS: Hepatobiliary excretion of glycyrrhizin involved human OATP1B1/1B3 (Oatp1b2 in rats)-mediated hepatic uptake from blood and human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (ABCP)/bile salt export pump (BSEP)/multidrug resistance protein 1 (Mrp2/Abcp/Bsep in rats)-mediated hepatic efflux into bile.	Glycyrrhizic Acid	40-52	ATP binding cassette subfamily B member 11	Homo sapiens	230-251
29908072-6	2018	KEY RESULTS: Hepatobiliary excretion of glycyrrhizin involved human OATP1B1/1B3 (Oatp1b2 in rats)-mediated hepatic uptake from blood and human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (ABCP)/bile salt export pump (BSEP)/multidrug resistance protein 1 (Mrp2/Abcp/Bsep in rats)-mediated hepatic efflux into bile.	Glycyrrhizic Acid	40-52	ATP binding cassette subfamily B member 11	Homo sapiens	253-257
29908072-6	2018	KEY RESULTS: Hepatobiliary excretion of glycyrrhizin involved human OATP1B1/1B3 (Oatp1b2 in rats)-mediated hepatic uptake from blood and human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (ABCP)/bile salt export pump (BSEP)/multidrug resistance protein 1 (Mrp2/Abcp/Bsep in rats)-mediated hepatic efflux into bile.	Glycyrrhizic Acid	40-52	ATP binding cassette subfamily B member 11	Homo sapiens	301-305
29412511-1	2018	BACKGROUND & AIMS: Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	85-89
29412511-1	2018	BACKGROUND & AIMS: Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	90-96
29412511-9	2018	Secondary bile acids were detected in patients without BSEP expression, suggesting biliary bile acid secretion through alternative routes.	Bile Acids and Salts	10-19	ATP binding cassette subfamily B member 11	Homo sapiens	55-59
29412511-1	2018	BACKGROUND & AIMS: Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases.	Bile Acids and Salts	62-71	ATP binding cassette subfamily B member 11	Homo sapiens	85-89
29412511-10	2018	A diagnostic panel comprising lithocholic acid (LCA), tauro-LCA, glyco-LCA and hyocholic acid was identified that could differentiate the ABCB11-mutated cohort from healthy controls and undiagnosed cholestasis patients (AUC=0.946, p < 0.0001) and, in non-ABCB11-mutated cholestasis patients, could distinguish BSEP dysfunction from normal BSEP function (9/12 vs 0/38, p < 0.0000001).	muricholic acid	79-93	ATP binding cassette subfamily B member 11	Homo sapiens	138-144
29412511-1	2018	BACKGROUND & AIMS: Genetic defects causing dysfunction in bile salt export pump (BSEP/ABCB11) lead to liver diseases.	Bile Acids and Salts	62-71	ATP binding cassette subfamily B member 11	Homo sapiens	90-96
29412511-2	2018	ABCB11 mutations alter the bile acid metabolome.	Bile Acids and Salts	27-36	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
29412511-7	2018	RESULTS: The overall hydrophobicity indices of total bile acids in both the ABCB11-mutated group (11.89 +- 1.07 min) and the undiagnosed cholestasis group (11.46 +- 1.07 min) were lower than those of healthy controls (13.69 +- 0.77 min) (both p < 0.005).	Bile Acids and Salts	53-63	ATP binding cassette subfamily B member 11	Homo sapiens	76-82
29091294-1	2018	Bile salt export pump (BSEP) adenosine triphosphate-binding cassette B11 (ABCB11) is a liver-specific ABC transporter that mediates canalicular bile salt excretion from hepatocytes.	Bile Acids and Salts	144-153	ATP binding cassette subfamily B member 11	Homo sapiens	74-80
29853564-5	2018	APPROACH AND RESULTS: Metformin-treated mouse or human primary hepatocytes showed increased expression of Abcg5/8 and the bile salt export pump, Bsep.	Metformin	22-31	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
29853564-5	2018	APPROACH AND RESULTS: Metformin-treated mouse or human primary hepatocytes showed increased expression of Abcg5/8 and the bile salt export pump, Bsep.	Bile Acids and Salts	122-131	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
29998165-7	2018	In conclusion, we describe the unique case of an adult male with choledocholithiasis, hepatolithiasis, and persistent conjugated hyperbilirubinemia after retrieval of stones, fulfilling the criteria for LPAC syndrome and with possible superimposed drug-induced liver injury, in whom ABCB4 and ABCB11 mutations were found, both of which had not been previously described in association with LPAC.	lpac	203-207	ATP binding cassette subfamily B member 11	Homo sapiens	293-299
29755014-9	2018	CONCLUSION: We concluded that Egyptian patients having chronic hepatitis C genotype 4 with CC genotype of ABCB11 SNP 1331T > C and high plasma bile acid levels at cutoff value of 75.5 mumol/L were associated with advanced hepatic fibrosis.	Bile Acids and Salts	146-155	ATP binding cassette subfamily B member 11	Homo sapiens	106-112
30464886-6	2018	Recent Findings: The genetic variations associated with AT-DILI have been identified in the genomic regions within or near genes encoding proteins in the following pathways: drug metabolizing enzymes (NAT2, CYP2E1, and GSTs), accumulation of bile acids, lipids, and heme metabolites (CYP7A1, BSEP, UGTs, and PXR), immune adaptation (HLAs and TNF-alpha), and oxidant challenge (TXNRD1, SOD1, BACH1, and MAFK).	Bile Acids and Salts	242-252	ATP binding cassette subfamily B member 11	Homo sapiens	292-296
30464886-6	2018	Recent Findings: The genetic variations associated with AT-DILI have been identified in the genomic regions within or near genes encoding proteins in the following pathways: drug metabolizing enzymes (NAT2, CYP2E1, and GSTs), accumulation of bile acids, lipids, and heme metabolites (CYP7A1, BSEP, UGTs, and PXR), immune adaptation (HLAs and TNF-alpha), and oxidant challenge (TXNRD1, SOD1, BACH1, and MAFK).	Heme	266-270	ATP binding cassette subfamily B member 11	Homo sapiens	292-296
29091294-6	2018	Hepatocytes of mutant zebrafish failed to excrete the fluorescently tagged bile acid that is a substrate of human BSEP.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	114-118
29309877-4	2018	Inhibition of BSEP by drugs potentially leads to cholestasis due to increased (toxic) intrahepatic concentrations of bile acids with subsequent cell injury.	Bile Acids and Salts	117-127	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
29272540-7	2018	Rather we show that most potent BSEP inhibitors are BDDCS class 2 drugs, which we have demonstrated previously is the BDDCS class most likely to be DILI related.	bddcs	52-57	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
29272540-7	2018	Rather we show that most potent BSEP inhibitors are BDDCS class 2 drugs, which we have demonstrated previously is the BDDCS class most likely to be DILI related.	bddcs	118-123	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
29309877-11	2018	Simulations showed that intracellular bile acid concentrations increase 1.7 fold in the presence of the BSEP inhibitors and cholestatic drugs cyclosporin A or glibenclamide, at intrahepatic concentrations of 6.6 and 20muM, respectively.	Bile Acids and Salts	38-47	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
29284646-2	2018	Reduction or absence of BSEP activity causes a failure of bile salt excretion, leading to accumulation of bile salts in hepatocytes and subsequent hepatic damage.	Bile Acids and Salts	58-67	ATP binding cassette subfamily B member 11	Homo sapiens	24-28
29404523-4	2018	We also suggest that nasobiliary drainage might be an ineffective approach in carriers of severe loss-of-function mutations of the bile salt export pump ABCB11.	Bile Acids and Salts	131-140	ATP binding cassette subfamily B member 11	Homo sapiens	153-159
29284646-2	2018	Reduction or absence of BSEP activity causes a failure of bile salt excretion, leading to accumulation of bile salts in hepatocytes and subsequent hepatic damage.	Bile Acids and Salts	106-116	ATP binding cassette subfamily B member 11	Homo sapiens	24-28
29284646-6	2018	We report a multidrug regimen of 4-phenylbutyrate, oxcarbazepine, and maralixibat (an experimental drug owned by Shire Pharmaceuticals, Dublin, Republic of Ireland) that completely controlled symptoms in 2 siblings with partial loss of BSEP activity.	4-phenylbutyric acid	33-49	ATP binding cassette subfamily B member 11	Homo sapiens	236-240
29284646-6	2018	We report a multidrug regimen of 4-phenylbutyrate, oxcarbazepine, and maralixibat (an experimental drug owned by Shire Pharmaceuticals, Dublin, Republic of Ireland) that completely controlled symptoms in 2 siblings with partial loss of BSEP activity.	Lopixibat	70-81	ATP binding cassette subfamily B member 11	Homo sapiens	236-240
29146462-0	2018	Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.	Bile Acids and Salts	17-26	ATP binding cassette subfamily B member 11	Homo sapiens	111-115
29146462-4	2018	One compound known for potent BSEP inhibition and severe DILI is troglitazone.	Troglitazone	65-77	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
28784620-1	2017	The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	51-61	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
28945205-1	2017	Recurrent bile salt export pump (rBSEP) disease has been reported in progressive familial intrahepatic cholestasis type 2 (PFIC2) patients following liver transplantation (LT) and is often refractory to standard anti-cellular rejection immunosuppressants.	Bile Acids and Salts	10-19	ATP binding cassette subfamily B member 11	Homo sapiens	123-128
29091211-3	2017	Objectives: We investigated the association between daclatasvir plasma concentrations at 2 weeks and 1 month of therapy and genetic variants (SNPs) in genes encoding transporters and nuclear factors (ABCB1, ABCB11 and HNF4alpha).	daclatasvir	52-63	ATP binding cassette subfamily B member 11	Homo sapiens	207-213
28784620-1	2017	The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	51-61	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
28784620-1	2017	The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi.	Bile Acids and Salts	51-61	ATP binding cassette subfamily B member 11	Homo sapiens	32-38
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	ATP binding cassette subfamily B member 11	Homo sapiens	251-255
28923092-8	2017	The gene study of the mother revealed the same missense variant in ABCC2/MRP2 but with a heterozygous status, and in addition a homozygous missense variant p.Val444Ala in the ATP-binding cassette, sub-family B member 11 gene ABCB11 that encodes the bile salt export pump.	Bile Acids and Salts	249-258	ATP binding cassette subfamily B member 11	Homo sapiens	175-219
28839429-5	2017	Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays.	Tritium	40-42	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
28839429-5	2017	Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays.	Taurocholic Acid	52-64	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
28839429-5	2017	Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays.	Taurocholic Acid	66-68	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
28839429-5	2017	Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays.	Taurochenodeoxycholic Acid	74-96	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
28839429-5	2017	Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays.	Taurochenodeoxycholic Acid	98-102	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
28839429-17	2017	Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.	Taurocholic Acid	92-94	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
28839429-17	2017	Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.	Taurocholic Acid	92-94	ATP binding cassette subfamily B member 11	Homo sapiens	161-165
28839429-17	2017	Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.	Taurochenodeoxycholic Acid	99-103	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
28839429-17	2017	Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.	Taurochenodeoxycholic Acid	99-103	ATP binding cassette subfamily B member 11	Homo sapiens	161-165
28629595-2	2017	Fex-3 could selectively activate intestinal FXR and promote the expression of BSEP and SHP while suppressing CYP7A1 which is involved in bile acids syntheses better than the reported intestinal-restricted FXR agonist fexaramine (Fex).	fexaramine-3	0-5	ATP binding cassette subfamily B member 11	Homo sapiens	78-82
28629595-2	2017	Fex-3 could selectively activate intestinal FXR and promote the expression of BSEP and SHP while suppressing CYP7A1 which is involved in bile acids syntheses better than the reported intestinal-restricted FXR agonist fexaramine (Fex).	fexaramine	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	78-82
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Troglitazone	8-20	ATP binding cassette subfamily B member 11	Homo sapiens	77-98
28805978-9	2017	The bile salt excretory pump (BSEP), a canalicular efflux transporter, increased by 6.4 +- 0.8-fold, and the basolateral efflux heterodimer transporters, organic solute transporter alpha (OSTalpha ) and OSTbeta increased by 6.4 +- 0.2-fold and 42.9 +- 7.9-fold, respectively.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
28805978-10	2017	The upregulation of BSEP and OSTalpha and OSTbeta, by OCA reduced the intracellular concentrations of d8 -TCA, a model bile acid, to 39.6 +- 8.9% relative to control.	d8 -tca	102-109	ATP binding cassette subfamily B member 11	Homo sapiens	20-24
28805978-10	2017	The upregulation of BSEP and OSTalpha and OSTbeta, by OCA reduced the intracellular concentrations of d8 -TCA, a model bile acid, to 39.6 +- 8.9% relative to control.	Bile Acids and Salts	119-128	ATP binding cassette subfamily B member 11	Homo sapiens	20-24
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Troglitazone	8-20	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Sulfates	29-36	ATP binding cassette subfamily B member 11	Homo sapiens	77-98
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Sulfates	29-36	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Troglitazone	107-119	ATP binding cassette subfamily B member 11	Homo sapiens	77-98
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Troglitazone	107-119	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	77-98
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Bile Acids and Salts	139-141	ATP binding cassette subfamily B member 11	Homo sapiens	77-98
28486596-2	2017	As both troglitazone and its sulfate metabolite are strong inhibitors of the bile salt export pump (BSEP), troglitazone-induced bile acid (BA) retention is thought to be one of the underlying mechanisms of liver injury.	Bile Acids and Salts	139-141	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
28486596-3	2017	However, pioglitazone is also a strong BSEP inhibitor, indicating other mechanisms may also be involved in troglitazone-induced BA retention.	Pioglitazone	9-21	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
28220208-3	2017	BSEP deficiency causes cytotoxic accumulation of bile salts in the hepatocyte that results in mild-to-severe forms of cholestasis.	Bile Acids and Salts	49-59	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
28527154-3	2017	Inhibition of BSEP leads to decreased bile flow and accumulation of cytotoxic bile salts in the liver.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Bile Acids and Salts	13-23	ATP binding cassette subfamily B member 11	Homo sapiens	60-81
28527154-1	2017	The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile.	Bile Acids and Salts	75-85	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
28527154-1	2017	The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile.	Bile Acids and Salts	75-85	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
28369588-7	2017	BSEP transport inhibition of taurcholic acids and glycocholic acids were similar for up to 29 drugs tested, in both the vesicle and hepatocyte-based assays.	taurcholic acids	29-45	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
28437613-2	2017	This transporter plays a pivotal role in secretion of phospholipids into bile and functions coordinately with BSEP to mediate the formation of bile acid-containing biliary micelles.	Phospholipids	54-67	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
28437613-2	2017	This transporter plays a pivotal role in secretion of phospholipids into bile and functions coordinately with BSEP to mediate the formation of bile acid-containing biliary micelles.	Bile Acids and Salts	143-152	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Bile Acids and Salts	13-23	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Bile Acids and Salts	13-23	ATP binding cassette subfamily B member 11	Homo sapiens	176-182
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	107-129	ATP binding cassette subfamily B member 11	Homo sapiens	60-81
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	107-129	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	107-129	ATP binding cassette subfamily B member 11	Homo sapiens	176-182
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	131-134	ATP binding cassette subfamily B member 11	Homo sapiens	60-81
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	131-134	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
28368001-3	2017	Secretion of bile acids in human and mammals depends on the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter encoded by ABCB11.	Adenosine Triphosphate	131-134	ATP binding cassette subfamily B member 11	Homo sapiens	176-182
28368001-6	2017	This work provides information on the snake ABCB11 sequence and helps further potential genetic manipulation to affect bile salt metabolism.	Bile Acids and Salts	119-128	ATP binding cassette subfamily B member 11	Homo sapiens	44-50
28150711-1	2017	Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure.	Bile Acids and Salts	77-87	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
28073941-1	2017	Tetrahydroxy bile acids (THBAs) are hydrophilic and are present at minimal or undetectable levels in healthy human adults, but are present at high levels in bile salt export pump (abcb11)-knockout mice.	tetrahydroxy bile acids	0-23	ATP binding cassette subfamily B member 11	Homo sapiens	180-186
28073941-1	2017	Tetrahydroxy bile acids (THBAs) are hydrophilic and are present at minimal or undetectable levels in healthy human adults, but are present at high levels in bile salt export pump (abcb11)-knockout mice.	thbas	25-30	ATP binding cassette subfamily B member 11	Homo sapiens	180-186
28073941-1	2017	Tetrahydroxy bile acids (THBAs) are hydrophilic and are present at minimal or undetectable levels in healthy human adults, but are present at high levels in bile salt export pump (abcb11)-knockout mice.	Bile Acids and Salts	157-166	ATP binding cassette subfamily B member 11	Homo sapiens	180-186
28150711-1	2017	Bile salt export pump (BSEP) plays an important role in hepatic secretion of bile acids and its deficiency results in severe cholestasis and liver failure.	Bile Acids and Salts	77-87	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
28146280-2	2017	BSEP is an efflux transporter that plays a critical role in the secretion of bile salts into the bile.	Bile Acids and Salts	77-87	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
28146280-3	2017	Inhibition of BSEP function by drugs can result in the buildup of bile salts in the liver and eventually leads to cholestasis and drug-induced liver injury (DILI).	Bile Acids and Salts	66-76	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
26961540-8	2017	From the further evaluation with the typical inhibitors of each transporter, it was confirmed that BPS is a substrate for P-gp, BCRP, OAT3, OATP1B1, OATP1B3 and MRP2, because the typical inhibitor, cyclosporine, had no effects on BPS transport by BSEP.	beraprost	99-102	ATP binding cassette subfamily B member 11	Homo sapiens	247-251
26961540-6	2017	Furthermore, we determined whether the transport of BPS was inhibited by the typical inhibitors of each transporter, i.e., verapamil for P-gp, Ko143 for BCRP, probenecid for OAT3, rifampicin for OATP1B1 and OATP1B3, cyclosporine for BSEP, and sulfobromophthalein (BSP) for MRP2.	beraprost	52-55	ATP binding cassette subfamily B member 11	Homo sapiens	233-237
27735997-5	2016	The presence of Res and Gres caused a significant increase in hepatic CYP7A1 and BSEP, indicating the increase in the synthesis and efflux of bile acids, respectively.	Bile Acids and Salts	142-152	ATP binding cassette subfamily B member 11	Homo sapiens	81-85
27916445-9	2017	BA levels decreased in PFIC-1 patients (1724+-3215 to 11+-6mumol/L, P=0.03) and in the single PFIC-3 patient (821 to 11.2mumol/L), but not significantly in PFIC-2 patients (193+-99 to 141+-118mumol/L, P=0.15).	Bile Acids and Salts	0-2	ATP binding cassette subfamily B member 11	Homo sapiens	156-162
27916445-15	2017	The higher BA levels could contribute to ongoing liver damage, and thus a higher transplant rate in PFIC-2 patients.	Bile Acids and Salts	11-13	ATP binding cassette subfamily B member 11	Homo sapiens	100-106
28066884-0	2017	Adverse reaction to apomorphine in a Collie homozygous for the ABCB1-1  (MDR1) mutation.	Apomorphine	20-31	ATP binding cassette subfamily B member 11	Homo sapiens	63-70
28275692-8	2017	Induction of ER stress in mice and HepG2 cells increased expression of the bile salt export pump (adenosine triphosphate binding cassette [Abc]b11) and a bile salt efflux pump (Abcc3).	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	139-146
27538918-6	2016	By contrast, inhibition of taurocholate efflux and/or human BSEP overexpressed in membrane vesicles was not observed with all cholestatic drugs; moreover, examples of noncholestatic compounds were reportedly found to inhibit BSEP.	Taurocholic Acid	27-39	ATP binding cassette subfamily B member 11	Homo sapiens	225-229
27759057-5	2016	Mechanisms behind the toxicity of the cholestatic compound chlorpromazine were accurately detected in both spheroid models, including intracellular BA accumulation, inhibition of ABCB11 expression and disruption of the F-actin cytoskeleton.	Chlorpromazine	59-73	ATP binding cassette subfamily B member 11	Homo sapiens	179-185
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Ketoconazole	84-96	ATP binding cassette subfamily B member 11	Homo sapiens	44-65
27757140-3	2016	Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2.	4-phenylbutyric acid	0-23	ATP binding cassette subfamily B member 11	Homo sapiens	80-85
27757140-3	2016	Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2.	4-phenylbutyric acid	25-29	ATP binding cassette subfamily B member 11	Homo sapiens	80-85
27757140-5	2016	So we described a case of Caucasian boy, suffering from a late onset PFIC2, listed for a liver transplant when he was sixteen and treated with 4-FB (200 mg per kilogram of body weight per day).	4-fb	143-147	ATP binding cassette subfamily B member 11	Homo sapiens	69-74
27676153-4	2016	Fusidic acid demonstrated concentration-dependent inhibition of human NTCP- and BSEP-mediated taurocholic acid transport with IC50 values of 44 and 3.8 muM, respectively.	Fusidic Acid	0-12	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
27676153-4	2016	Fusidic acid demonstrated concentration-dependent inhibition of human NTCP- and BSEP-mediated taurocholic acid transport with IC50 values of 44 and 3.8 muM, respectively.	Taurocholic Acid	94-110	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
27676153-5	2016	Inhibition of BSEP activity by fusidic acid was also consistent with the potent disruption of cellular biliary flux (AC50 = 11 muM) in the hepatocyte imaging assay technology assay, with minimal impact on other toxicity end points (e.g., cytotoxicity, mitochondrial membrane potential, reactive oxygen species generation, glutathione depletion, etc.).	Fusidic Acid	31-43	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
27676153-5	2016	Inhibition of BSEP activity by fusidic acid was also consistent with the potent disruption of cellular biliary flux (AC50 = 11 muM) in the hepatocyte imaging assay technology assay, with minimal impact on other toxicity end points (e.g., cytotoxicity, mitochondrial membrane potential, reactive oxygen species generation, glutathione depletion, etc.).	Reactive Oxygen Species	286-309	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
27676153-5	2016	Inhibition of BSEP activity by fusidic acid was also consistent with the potent disruption of cellular biliary flux (AC50 = 11 muM) in the hepatocyte imaging assay technology assay, with minimal impact on other toxicity end points (e.g., cytotoxicity, mitochondrial membrane potential, reactive oxygen species generation, glutathione depletion, etc.).	Glutathione	322-333	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
27676153-9	2016	The magnitudes of in vivo interaction (R values) resulting from the inhibition of OATP1B1, UGT1A1, NTCP, and BSEP transport were ~1.9-2.6, 1.1-1.2, 1.0-1.1, and 1.4-1.7, respectively, which are indicative of some degree of inherent toxicity risk, particularly via inhibition of OATP and BSEP.	periodate-oxidized adenosine 5'-triphosphate	82-86	ATP binding cassette subfamily B member 11	Homo sapiens	109-113
27676153-9	2016	The magnitudes of in vivo interaction (R values) resulting from the inhibition of OATP1B1, UGT1A1, NTCP, and BSEP transport were ~1.9-2.6, 1.1-1.2, 1.0-1.1, and 1.4-1.7, respectively, which are indicative of some degree of inherent toxicity risk, particularly via inhibition of OATP and BSEP.	periodate-oxidized adenosine 5'-triphosphate	82-86	ATP binding cassette subfamily B member 11	Homo sapiens	287-291
27676153-10	2016	Collectively, these observations indicate that inhibition of human BSEP by fusidic acid could affect bile acid homeostasis, resulting in cholestatic hepatotoxicity in the clinic.	Fusidic Acid	75-87	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27676153-10	2016	Collectively, these observations indicate that inhibition of human BSEP by fusidic acid could affect bile acid homeostasis, resulting in cholestatic hepatotoxicity in the clinic.	Bile Acids and Salts	101-110	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Ketoconazole	84-96	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Saquinavir	98-108	ATP binding cassette subfamily B member 11	Homo sapiens	44-65
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Saquinavir	98-108	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Cyclosporine	110-122	ATP binding cassette subfamily B member 11	Homo sapiens	44-65
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Cyclosporine	110-122	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Troglitazone	128-140	ATP binding cassette subfamily B member 11	Homo sapiens	44-65
27000539-5	2016	The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone.	Troglitazone	128-140	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
27059119-1	2016	The bile salt export pump (BSEP) is expressed on the canalicular membrane of hepatocytes regulating liver bile salt excretion, and impairment of BSEP function may lead to cholestasis in humans.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
27059119-1	2016	The bile salt export pump (BSEP) is expressed on the canalicular membrane of hepatocytes regulating liver bile salt excretion, and impairment of BSEP function may lead to cholestasis in humans.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
26950211-12	2016	GCDCA-, CDCA- and GW4064- preconditioning enhanced ABCB11 mRNA levels, but in contrast to the bile acids, GW4064 did not significantly reduce GCDCA-induced caspase-3/7 activity.	Chenodeoxycholic Acid	1-5	ATP binding cassette subfamily B member 11	Homo sapiens	51-57
27001813-5	2016	BSEP was strongly inhibited by itraconazole and hydroxyitraconazole (3 and 17 muM, respectively).	Itraconazole	31-43	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
27001813-5	2016	BSEP was strongly inhibited by itraconazole and hydroxyitraconazole (3 and 17 muM, respectively).	hydroxyitraconazole	48-67	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
27253337-5	2016	There was a strong correlation between mGES and the ABC-16 scale (rs = 0.85; p < 0.001).	mges	39-43	ATP binding cassette subfamily B member 11	Homo sapiens	52-58
27114171-1	2016	The bile salt export pump BSEP mediates bile formation.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	26-30
26910619-0	2016	Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.	Bile Acids and Salts	51-60	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
26910619-2	2016	BSEP KO in HepaRG cells led to time-dependent BA accumulation, resulting in reduced biosynthesis of BAs and altered BA disposition.	Bile Acids and Salts	46-48	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
26910619-2	2016	BSEP KO in HepaRG cells led to time-dependent BA accumulation, resulting in reduced biosynthesis of BAs and altered BA disposition.	Bile Acids and Salts	100-102	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
26910619-7	2016	The results revealed that functional impairment of BSEP predisposes the cells to altered BA disposition and is a susceptive factor to drug-induced cholestatic injury.	Bile Acids and Salts	89-91	ATP binding cassette subfamily B member 11	Homo sapiens	51-55
26910619-9	2016	As intracellular BA accumulation is determined by BSEP function and the subsequent adaptive gene regulation, assessment of intracellular BA accumulation in HepaRG-KO cells could be a useful approach to evaluate drug-induced liver injury (DILI) potentials of drugs that could disrupt other BA homeostasis pathways beyond BSEP inhibition.	Bile Acids and Salts	17-19	ATP binding cassette subfamily B member 11	Homo sapiens	50-54
27112167-10	2016	Our in vitro model for MDR3-mediated phospholipid secretion facilitates parallel screening for MDR3 and BSEP inhibitors.	Phospholipids	37-49	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
26950211-12	2016	GCDCA-, CDCA- and GW4064- preconditioning enhanced ABCB11 mRNA levels, but in contrast to the bile acids, GW4064 did not significantly reduce GCDCA-induced caspase-3/7 activity.	GW 4064	18-24	ATP binding cassette subfamily B member 11	Homo sapiens	51-57
26950211-12	2016	GCDCA-, CDCA- and GW4064- preconditioning enhanced ABCB11 mRNA levels, but in contrast to the bile acids, GW4064 did not significantly reduce GCDCA-induced caspase-3/7 activity.	Glycochenodeoxycholic Acid	0-5	ATP binding cassette subfamily B member 11	Homo sapiens	51-57
26682943-5	2016	RESULTS: A strong inhibition (IC50 value <15 muM) was observed for clofazimine (P-gp, BCRP and MRP1), thioridazine (BCRP), timcodar (P-gp, BSEP and MRP1) and SQ109 (P-gp and BCRP).	Thioridazine	105-117	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
26756876-2	2016	Encouraging preliminary responses to 4-PBA have been reported in liver disease secondary to mutations in ABCB11 and ATP8B1.	4-pba	37-42	ATP binding cassette subfamily B member 11	Homo sapiens	105-111
26223708-0	2016	Successful treatment with 4-phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption.	4-phenylbutyric acid	26-42	ATP binding cassette subfamily B member 11	Homo sapiens	61-109
26223708-0	2016	Successful treatment with 4-phenylbutyrate in a patient with benign recurrent intrahepatic cholestasis type 2 refractory to biliary drainage and bilirubin absorption.	Bilirubin	145-154	ATP binding cassette subfamily B member 11	Homo sapiens	61-109
26223708-1	2016	AIM: Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary bile salt secretion, and presents with repeated intermittent cholestasis with refractory itching.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	5-53
26223708-1	2016	AIM: Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary bile salt secretion, and presents with repeated intermittent cholestasis with refractory itching.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	55-60
26223708-1	2016	AIM: Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary bile salt secretion, and presents with repeated intermittent cholestasis with refractory itching.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	88-94
26223708-1	2016	AIM: Benign recurrent intrahepatic cholestasis type 2 (BRIC2) is caused by mutations in ABCB11, a gene encoding the bile salt export pump (BSEP) that mediates biliary bile salt secretion, and presents with repeated intermittent cholestasis with refractory itching.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
26223708-3	2016	We previously provided experimental and clinical evidence suggesting the therapeutic potential of 4-phenylbutyrate (4PB) for the cholestatic attacks of BRIC2.	4-phenylbutyric acid	98-114	ATP binding cassette subfamily B member 11	Homo sapiens	152-157
26223708-7	2016	RESULTS: The patient was diagnosed with BRIC2 because he had non-synonymous mutations (c.1211A>G [p.D404G] and 1331T>C [p.V444A]) in ABCB11, reduced hepatocanalicular expression of BSEP and low biliary bile salt concentrations.	Bile Acids and Salts	208-217	ATP binding cassette subfamily B member 11	Homo sapiens	40-45
26223708-7	2016	RESULTS: The patient was diagnosed with BRIC2 because he had non-synonymous mutations (c.1211A>G [p.D404G] and 1331T>C [p.V444A]) in ABCB11, reduced hepatocanalicular expression of BSEP and low biliary bile salt concentrations.	Bile Acids and Salts	208-217	ATP binding cassette subfamily B member 11	Homo sapiens	139-145
26642869-8	2016	After in vitro testing of selected candidates, a marketed drug, bromocriptin, was identified for the first time as BSEP inhibitor.	Bromocriptine	64-76	ATP binding cassette subfamily B member 11	Homo sapiens	115-119
26573700-1	2016	INTRODUCTION: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile.	Bile Acids and Salts	128-138	ATP binding cassette subfamily B member 11	Homo sapiens	18-39
26573700-1	2016	INTRODUCTION: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile.	Bile Acids and Salts	128-138	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
26573700-1	2016	INTRODUCTION: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile.	Bile Acids and Salts	128-138	ATP binding cassette subfamily B member 11	Homo sapiens	46-52
26682943-5	2016	RESULTS: A strong inhibition (IC50 value <15 muM) was observed for clofazimine (P-gp, BCRP and MRP1), thioridazine (BCRP), timcodar (P-gp, BSEP and MRP1) and SQ109 (P-gp and BCRP).	Clofazimine	70-81	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
26682943-5	2016	RESULTS: A strong inhibition (IC50 value <15 muM) was observed for clofazimine (P-gp, BCRP and MRP1), thioridazine (BCRP), timcodar (P-gp, BSEP and MRP1) and SQ109 (P-gp and BCRP).	timcodar	126-134	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
26340566-10	2016	CAB is an inhibitor of OAT1 (IC50 0.81 microM) and OAT3 (IC50 0.41 microM) but did not or only weakly inhibited Pgp, BCRP, MRP2, MRP4, MATE1, MATE2-K, OATP1B1, OATP1B3, OCT1, OCT2 or BSEP.	cabotegravir	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	41-72	ATP binding cassette subfamily B member 11	Homo sapiens	339-343
26462574-4	2015	Treatment by the reference PKC activator phorbol 12-myristate 13-acetate (PMA) for 48h was shown to decrease mRNA expression of various sinusoidal transporters, including OATP1B1, OATP2B1, NTCP, OCT1 and MRP3, but to increase that of OATP1B3, whereas mRNA expression of canalicular transporters was transiently enhanced (MDR1), decreased (BSEP and MRP2) or unchanged (BCRP) in human hepatoma HepaRG cells.	Tetradecanoylphorbol Acetate	74-77	ATP binding cassette subfamily B member 11	Homo sapiens	339-343
25716872-4	2015	Four PFIC2 patients harboring at least one missense mutation (p.G982R, p.R1128C, and p.T1210P) were treated orally with 4-PB and followed prospectively.	4-phenylbutyric acid	120-124	ATP binding cassette subfamily B member 11	Homo sapiens	5-10
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Phospholipids	242-254	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Phospholipids	242-254	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Phospholipids	242-254	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Bile Acids and Salts	375-385	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Bile Acids and Salts	375-385	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
26517915-4	2015	The bile salt export pump (BSEP) ABCB11 transports the BAs and drives bile flow from the liver, but it is now clear that two lipid transporters, ABCB4 (which flops PC into the bile) and the P-type ATPase ATP8B1/CDC50 (which flips a different phospholipid in the opposite direction) play equally critical roles that protect the biliary tree from the detergent activity of the bile acids.	Bile Acids and Salts	375-385	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
25716872-8	2015	Treatment with 4-PB and UDCA partially corrected Bsep mutant targeting.	4-phenylbutyric acid	15-19	ATP binding cassette subfamily B member 11	Homo sapiens	49-53
25716872-13	2015	CONCLUSION: 4-PB therapy may be efficient in selected patients with PFIC2 owing to ABCB11 missense mutations affecting BSEP canalicular targeting.	4-phenylbutyric acid	12-16	ATP binding cassette subfamily B member 11	Homo sapiens	68-73
25716872-13	2015	CONCLUSION: 4-PB therapy may be efficient in selected patients with PFIC2 owing to ABCB11 missense mutations affecting BSEP canalicular targeting.	4-phenylbutyric acid	12-16	ATP binding cassette subfamily B member 11	Homo sapiens	83-89
25716872-13	2015	CONCLUSION: 4-PB therapy may be efficient in selected patients with PFIC2 owing to ABCB11 missense mutations affecting BSEP canalicular targeting.	4-phenylbutyric acid	12-16	ATP binding cassette subfamily B member 11	Homo sapiens	119-123
25716872-14	2015	Bile secretion improvement may be a result of the ability of 4-PB to retarget mutated BSEP.	4-phenylbutyric acid	61-65	ATP binding cassette subfamily B member 11	Homo sapiens	86-90
25342496-4	2015	The three subtypes of PFIC are defined by the involved genes: PFIC-1, PFIC-2, and PFIC-3 are due to mutations of P-type ATPase ATP8B1 (familial intrahepatic cholestasis 1, FIC1), the ATP binding cassette transporter ABCB11 (bile salt export pump, BSEP), or ABCB4 (multidrug resistance protein 3, MDR3), respectively.	Bile Acids and Salts	224-233	ATP binding cassette subfamily B member 11	Homo sapiens	70-76
25711339-1	2015	The bile salt export pump (BSEP) plays an important role in bile acid excretion.	Bile Acids and Salts	60-69	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
25735837-10	2015	Both MRP4 and BSEP inhibitor pharmacophore models were characterized by hydrophobic and hydrogen-bond acceptor features, albeit in distinct spatial arrangements.	Hydrogen	88-96	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
25711339-1	2015	The bile salt export pump (BSEP) plays an important role in bile acid excretion.	Bile Acids and Salts	60-69	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
25847799-0	2015	Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2.	Steroids	61-69	ATP binding cassette subfamily B member 11	Homo sapiens	87-93
25847799-3	2015	We report on a young woman and a boy who clinically presented with PFIC-2 phenotypes and dramatically improved with steroid treatment.	Steroids	116-123	ATP binding cassette subfamily B member 11	Homo sapiens	67-73
25847799-14	2015	In conclusion, the clinical courses suggest that patients with BSEP deficiency and residual BSEP activity may benefit from steroid-based therapy, which represents a new treatment option.	Steroids	123-130	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
25675114-2	2015	We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy.	Estradiol	39-55	ATP binding cassette subfamily B member 11	Homo sapiens	99-103
25690737-6	2015	Contrary to other transporters, NTCP and BSEP were less abundant and active in HepaRG cells, cellular uptake of taurocholate was 2.2- and 1.4-fold and bile excretion index 2.8- and 2.6-fold lower, than in SCHHs and CCHHs, respectively.	Taurocholic Acid	112-124	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
25690737-6	2015	Contrary to other transporters, NTCP and BSEP were less abundant and active in HepaRG cells, cellular uptake of taurocholate was 2.2- and 1.4-fold and bile excretion index 2.8- and 2.6-fold lower, than in SCHHs and CCHHs, respectively.	schhs	205-210	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
25690737-6	2015	Contrary to other transporters, NTCP and BSEP were less abundant and active in HepaRG cells, cellular uptake of taurocholate was 2.2- and 1.4-fold and bile excretion index 2.8- and 2.6-fold lower, than in SCHHs and CCHHs, respectively.	cchhs	215-220	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
25675114-2	2015	We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy.	Estradiol	39-55	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
25675114-2	2015	We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy.	Bile Acids and Salts	76-85	ATP binding cassette subfamily B member 11	Homo sapiens	99-103
25675114-2	2015	We have previously shown that estrogen 17beta-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor (ER)-alpha and farnesoid X receptor (FXR) and transrepression of BSEP by E2/ERalpha is an etiological contributing factor to intrahepatic cholestasis of pregnancy.	Bile Acids and Salts	76-85	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
25467130-9	2015	Bosentan exhibited a positive exposure-adjusted signal in one assay (BSEP inhibition) and a moderate CVB body burden.	Bosentan	0-8	ATP binding cassette subfamily B member 11	Homo sapiens	69-73
25661339-0	2015	ABCB11 and ABCB1 gene polymorphisms impact on telaprevir pharmacokinetic at one month of therapy.	telaprevir	46-56	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
25661339-6	2015	Telaprevir Ctrough levels were influenced by Metavir score (P=0.023), ABCB1 2677 G>T (P=0.006), ABCB1 1236 C>T (P=0.015) and ABCB11 1131 T>C (P=0.033) SNPs.	telaprevir	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
25378077-1	2015	AIMS: Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux.	Bile Acids and Salts	107-116	ATP binding cassette subfamily B member 11	Homo sapiens	6-27
25378077-1	2015	AIMS: Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux.	Bile Acids and Salts	107-116	ATP binding cassette subfamily B member 11	Homo sapiens	29-33
25297453-8	2015	Human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (BCRP)/bile salt export pump (BSEP)/multidrug resistance protein-1 and rat Mrp2/Bcrp/Bsep also mediated the transport of the 20(S)-protopanaxatriol-type ginsenosides.	protopanaxatriol	213-233	ATP binding cassette subfamily B member 11	Homo sapiens	93-114
25297453-8	2015	Human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (BCRP)/bile salt export pump (BSEP)/multidrug resistance protein-1 and rat Mrp2/Bcrp/Bsep also mediated the transport of the 20(S)-protopanaxatriol-type ginsenosides.	protopanaxatriol	213-233	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
25297453-8	2015	Human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (BCRP)/bile salt export pump (BSEP)/multidrug resistance protein-1 and rat Mrp2/Bcrp/Bsep also mediated the transport of the 20(S)-protopanaxatriol-type ginsenosides.	Ginsenosides	239-251	ATP binding cassette subfamily B member 11	Homo sapiens	93-114
25297453-8	2015	Human multidrug resistance-associated protein (MRP)2/breast cancer resistance protein (BCRP)/bile salt export pump (BSEP)/multidrug resistance protein-1 and rat Mrp2/Bcrp/Bsep also mediated the transport of the 20(S)-protopanaxatriol-type ginsenosides.	Ginsenosides	239-251	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
25323205-4	2015	Exon sequencing was performed in order to analyze the ABCB4 and ABCB11 genes of 176 patients with PIS and 178 healthy subjects.	Monothiopyrophosphoric acid	98-101	ATP binding cassette subfamily B member 11	Homo sapiens	64-70
25135348-4	2015	Significant associations were also found for ABCB11 and SLC30A8 single-nucleotide polymorphisms (SNPs) and glucose responses, and an SEC61A2 SNP with a potassium response to GIK.	Glucose	107-114	ATP binding cassette subfamily B member 11	Homo sapiens	45-51
25535031-5	2015	In contrast, desmethyl bosentan induced mRNA expression of cytochrome P450 3A4 (CYP3A4, about 6-fold at 50 muM), ABCB1 (P-gp, about 4.5-fold at 50 muM), and ABCG2 (breast cancer resistance protein, about 2-fold at 50 muM), whereas CYP2C19, ABCB11, and ABCC2 (multidrug resistance-associated protein 2) were not induced in LS180 cells.	Desmethyl Bosentan	13-31	ATP binding cassette subfamily B member 11	Homo sapiens	240-246
26045261-6	2015	Furthermore, progesterone sulfates are competitive inhibitors of biliary influx (NTCP) and efflux (BSEP) transport proteins, actions likely to further exacerbate hypercholanaemia and cholestasis.	progesterone sulfates	13-34	ATP binding cassette subfamily B member 11	Homo sapiens	99-103
25323205-6	2015	69233, G>A) and two other mutations in ABCB11, reference single nucleotide polymorphism (rs)118109635 and rs497692, were identified in association with PIS (P<0.001, P=0.04 and P=0.02, respectively).	Monothiopyrophosphoric acid	155-158	ATP binding cassette subfamily B member 11	Homo sapiens	42-48
25323205-12	2015	The missense mutation rs118109635 was located on exon 21 of ABCB11 and was associated with the increased expression of ABCB11 protein (P=0.032) as well as altered bile salt export pump function.	Bile Acids and Salts	163-172	ATP binding cassette subfamily B member 11	Homo sapiens	60-66
24729004-1	2014	UNLABELLED: Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	81-91	ATP binding cassette subfamily B member 11	Homo sapiens	12-33
24729004-1	2014	UNLABELLED: Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	81-91	ATP binding cassette subfamily B member 11	Homo sapiens	35-39
24729004-1	2014	UNLABELLED: Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	12-33
24729004-1	2014	UNLABELLED: Bile salt export pump (BSEP) is responsible for biliary secretion of bile acids, a rate-limiting step in the enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	35-39
24729004-6	2014	The transcriptional dynamics of BSEP was inversely correlated with serum 17beta-estradiol (E2) levels before, during, and after gestation.	Estradiol	73-89	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
24729004-6	2014	The transcriptional dynamics of BSEP was inversely correlated with serum 17beta-estradiol (E2) levels before, during, and after gestation.	Estradiol	91-93	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
25444678-5	2014	Pharmacological modulation of AA metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11.	Aspirin	47-54	ATP binding cassette subfamily B member 11	Homo sapiens	191-197
25426072-3	2014	In this paper, we use DILIsym  to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explore whether we can predict that hepatotoxic BSEP inhibitors can cause bile acid accumulation to reach toxic levels.	Bosentan	96-104	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
25426072-3	2014	In this paper, we use DILIsym  to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explore whether we can predict that hepatotoxic BSEP inhibitors can cause bile acid accumulation to reach toxic levels.	cp-724	109-115	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
25426072-3	2014	In this paper, we use DILIsym  to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explore whether we can predict that hepatotoxic BSEP inhibitors can cause bile acid accumulation to reach toxic levels.	Telmisartan	159-170	ATP binding cassette subfamily B member 11	Homo sapiens	144-148
25426072-3	2014	In this paper, we use DILIsym  to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explore whether we can predict that hepatotoxic BSEP inhibitors can cause bile acid accumulation to reach toxic levels.	Telmisartan	159-170	ATP binding cassette subfamily B member 11	Homo sapiens	144-148
25426072-3	2014	In this paper, we use DILIsym  to simulate the DILI response of the hepatotoxic BSEP inhibitors bosentan and CP-724,714 and the non-hepatotoxic BSEP inhibitor telmisartan in humans in order to explore whether we can predict that hepatotoxic BSEP inhibitors can cause bile acid accumulation to reach toxic levels.	Bile Acids and Salts	267-276	ATP binding cassette subfamily B member 11	Homo sapiens	80-84
25444678-5	2014	Pharmacological modulation of AA metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11.	Leukotrienes	85-97	ATP binding cassette subfamily B member 11	Homo sapiens	191-197
25444678-5	2014	Pharmacological modulation of AA metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11.	Leukotrienes	99-102	ATP binding cassette subfamily B member 11	Homo sapiens	191-197
25444678-5	2014	Pharmacological modulation of AA metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11.	Lipoxins	108-116	ATP binding cassette subfamily B member 11	Homo sapiens	191-197
25444678-5	2014	Pharmacological modulation of AA metabolism by aspirin induced hepatic generation of leukotrienes (LTs) and lipoxins (LXs), thereby increasing hepatic expression of the bile salt export pump Abcb11.	Lipoxins	118-121	ATP binding cassette subfamily B member 11	Homo sapiens	191-197
25444678-6	2014	Induction of Abcb11 translated in enhanced reverse cholesterol transport, one key function of HDL.	Cholesterol	51-62	ATP binding cassette subfamily B member 11	Homo sapiens	13-19
25006780-6	2014	BSEP inhibition in humans is predicted to increase liver concentrations of conjugated chenodeoxycholic acid (CDCA) and sulfate-conjugated lithocholic acid (LCA) while the concentration of other liver BAs remains constant or decreases.	Chenodeoxycholic Acid	86-107	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
25332267-2	2014	Bosentan is metabolized by the cytochrome CYP2C9 and inhibits the bile salt export pump, which is encoded by ABCB11.	Bosentan	0-8	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
25332267-2	2014	Bosentan is metabolized by the cytochrome CYP2C9 and inhibits the bile salt export pump, which is encoded by ABCB11.	Bile Acids and Salts	66-75	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
25332267-3	2014	This suggests that genetic variants of CYP2C9 and/or ABCB11 may predispose patients to bosentan-induced liver injury.	Bosentan	87-95	ATP binding cassette subfamily B member 11	Homo sapiens	53-59
25022842-4	2014	We found a previously unidentified pharmacological effect of 4-phenylbutyrate (4PB) that increases the expression and function of BSEP.	4-phenylbutyric acid	61-77	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
25022842-4	2014	We found a previously unidentified pharmacological effect of 4-phenylbutyrate (4PB) that increases the expression and function of BSEP.	4-phenylbutyric acid	79-82	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
25085279-2	2014	ABCB11 encodes the bile salt export pump (BSEP), the major transporter responsible for biliary bile acid secretion, which expression is restricted to hepatocytes.	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
25085279-2	2014	ABCB11 encodes the bile salt export pump (BSEP), the major transporter responsible for biliary bile acid secretion, which expression is restricted to hepatocytes.	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	19-40
25085279-2	2014	ABCB11 encodes the bile salt export pump (BSEP), the major transporter responsible for biliary bile acid secretion, which expression is restricted to hepatocytes.	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	42-46
24799086-4	2014	Since BSEP is an energy-dependent protein responsible for the efflux of bile acids from hepatocytes, it was hypothesized that humans exposed to drugs that impair both mitochondrial energetics and BSEP functional activity are more sensitive to more severe manifestations of DILI than drugs that only have a single liability factor.	Bile Acids and Salts	72-82	ATP binding cassette subfamily B member 11	Homo sapiens	6-10
25006780-6	2014	BSEP inhibition in humans is predicted to increase liver concentrations of conjugated chenodeoxycholic acid (CDCA) and sulfate-conjugated lithocholic acid (LCA) while the concentration of other liver BAs remains constant or decreases.	Chenodeoxycholic Acid	109-113	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
25006780-6	2014	BSEP inhibition in humans is predicted to increase liver concentrations of conjugated chenodeoxycholic acid (CDCA) and sulfate-conjugated lithocholic acid (LCA) while the concentration of other liver BAs remains constant or decreases.	Sulfates	119-126	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
25006780-6	2014	BSEP inhibition in humans is predicted to increase liver concentrations of conjugated chenodeoxycholic acid (CDCA) and sulfate-conjugated lithocholic acid (LCA) while the concentration of other liver BAs remains constant or decreases.	Lithocholic Acid	138-154	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
25006780-6	2014	BSEP inhibition in humans is predicted to increase liver concentrations of conjugated chenodeoxycholic acid (CDCA) and sulfate-conjugated lithocholic acid (LCA) while the concentration of other liver BAs remains constant or decreases.	Lithocholic Acid	156-159	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
24769543-2	2014	Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic accumulation of cytotoxic bile salts, which eventually results in hepatocellular damage.	Bosentan	17-25	ATP binding cassette subfamily B member 11	Homo sapiens	39-60
24375397-13	2014	Our results suggest that cholestasis in MVID patients results from (1) impairment of the MYO5B/RAB11A apical recycling endosome pathway in hepatocytes, (2) altered targeting of BSEP to the canalicular membrane, and (3) increased ileal BA absorption.	Bile Acids and Salts	235-237	ATP binding cassette subfamily B member 11	Homo sapiens	177-181
24769543-2	2014	Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic accumulation of cytotoxic bile salts, which eventually results in hepatocellular damage.	Bosentan	17-25	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
24769543-2	2014	Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic accumulation of cytotoxic bile salts, which eventually results in hepatocellular damage.	Bile Acids and Salts	121-131	ATP binding cassette subfamily B member 11	Homo sapiens	39-60
24769543-2	2014	Mechanistically, bosentan inhibits the bile salt export pump (BSEP) leading to an intrahepatic accumulation of cytotoxic bile salts, which eventually results in hepatocellular damage.	Bile Acids and Salts	121-131	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
24769543-3	2014	BSEP inhibition by bosentan is amplified by its accumulation in the liver as bosentan is a substrate of organic anion-transporting polypeptide (OATP) transport proteins.	Bosentan	19-27	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
24769543-3	2014	BSEP inhibition by bosentan is amplified by its accumulation in the liver as bosentan is a substrate of organic anion-transporting polypeptide (OATP) transport proteins.	Bosentan	77-85	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
24769543-7	2014	Interaction with the sodium taurocholate cotransporting polypeptide and BSEP transport proteins involved in hepatic bile salt homeostasis is therefore limited due to the low intrahepatic drug concentrations.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	72-76
23685087-1	2014	The bile salt export pump (BSEP, ABCB11) is the primary transporter of bile acids from the hepatocyte to the biliary system.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
24842639-0	2014	CYP2C9, SLCO1B1, SLCO1B3, and ABCB11 polymorphisms in patients with bosentan-induced liver toxicity.	Bosentan	68-76	ATP binding cassette subfamily B member 11	Homo sapiens	30-36
24842639-4	2014	We conducted a nested case-control study to further explore the relationship between functional polymorphisms of gene products involved in bosentan pharmacokinetics (OATP1B1, OATP1B3, and CYP2C9) or hepatobiliary transporters affected by bosentan (ABCB11) and bosentan-induced liver toxicity.	Bosentan	139-147	ATP binding cassette subfamily B member 11	Homo sapiens	248-254
23685087-1	2014	The bile salt export pump (BSEP, ABCB11) is the primary transporter of bile acids from the hepatocyte to the biliary system.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
23685087-1	2014	The bile salt export pump (BSEP, ABCB11) is the primary transporter of bile acids from the hepatocyte to the biliary system.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
24399466-1	2014	The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
24522246-5	2014	Also, our data indicated that silibinin, in a dose-dependent manner with applying no cytotoxic effects, inhibited cell proliferation and reduced mRNA expression levels of some transporter genes e.g. MDR1, MRP3, MRP2, MRP1, MRP5, MRP4, ABCG2, ABCB11, MRP6 and MRP7.	Silybin	30-39	ATP binding cassette subfamily B member 11	Homo sapiens	242-248
24154606-2	2014	The multidrug resistance-associated proteins (MRP) 3 and 4 are postulated to be compensatory hepatic basolateral bile acid efflux transporters when biliary excretion by the bile salt export pump (BSEP) is impaired.	Bile Acids and Salts	113-122	ATP binding cassette subfamily B member 11	Homo sapiens	196-200
24399466-1	2014	The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
24399466-1	2014	The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
24399466-1	2014	The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	50-56
24399466-1	2014	The bile salt export pump (BSEP/Bsep; gene symbol ABCB11/Abcb11) translocates bile salts across the hepatocyte canalicular membrane into bile in humans and mice.	Bile Acids and Salts	78-88	ATP binding cassette subfamily B member 11	Homo sapiens	57-63
24713091-2	2014	BSEP is the key membrane transporter responsible for the transport of bile acids from hepatocytes into bile.	Bile Acids and Salts	70-80	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
24713091-4	2014	To generate input and validation data sets, in vitro experiments with membrane vesicles overexpressing human BSEP were used to assess the effect of compounds (50 muM) on BSEP-mediated (3)H-taurocholic acid transport.	Taurocholic Acid	189-205	ATP binding cassette subfamily B member 11	Homo sapiens	170-174
24338587-8	2014	Furthermore, a leucine-enriched diet restored mammalian target of rapamycin (mTOR) activation, acetylation of FXR and histones, leading to an overall lower BA production through SHP-inhibition of Cyp7A1 and higher transport (BSEP) and detoxification (Sult2a1) leading to an improved liver regeneration.	Leucine	15-22	ATP binding cassette subfamily B member 11	Homo sapiens	225-229
24627218-4	2014	Lenalidomide was also evaluated as an inhibitor of P-gp, BCRP, MRP2, OCT2, OAT1, OAT3, OATP1B1, OATP1B3 and bile salt export pump (BSEP).	Lenalidomide	0-12	ATP binding cassette subfamily B member 11	Homo sapiens	108-129
24627218-4	2014	Lenalidomide was also evaluated as an inhibitor of P-gp, BCRP, MRP2, OCT2, OAT1, OAT3, OATP1B1, OATP1B3 and bile salt export pump (BSEP).	Lenalidomide	0-12	ATP binding cassette subfamily B member 11	Homo sapiens	131-135
24115749-1	2014	The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs).	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
24115749-1	2014	The bile salt export pump (BSEP) is located on the canalicular plasma membrane of hepatocytes and plays an important role in the biliary clearance of bile acids (BAs).	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
24154606-2	2014	The multidrug resistance-associated proteins (MRP) 3 and 4 are postulated to be compensatory hepatic basolateral bile acid efflux transporters when biliary excretion by the bile salt export pump (BSEP) is impaired.	Bile Acids and Salts	113-122	ATP binding cassette subfamily B member 11	Homo sapiens	173-194
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	188-198	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	188-198	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
24335466-1	2014	The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury.	Bile Acids and Salts	188-198	ATP binding cassette subfamily B member 11	Homo sapiens	118-122
24335466-8	2014	Further investigation of the five potent repressors revealed that transcriptional repression of BSEP by lopinavir and troglitazone may occur through their interaction with FXR, whereas others are via FXR-independent yet unidentified pathways.	Lopinavir	104-113	ATP binding cassette subfamily B member 11	Homo sapiens	96-100
24335466-8	2014	Further investigation of the five potent repressors revealed that transcriptional repression of BSEP by lopinavir and troglitazone may occur through their interaction with FXR, whereas others are via FXR-independent yet unidentified pathways.	Troglitazone	118-130	ATP binding cassette subfamily B member 11	Homo sapiens	96-100
24332840-6	2014	In LS180 cells, telaprevir strongly induced mRNA expression of ABCG2 (4.3-fold at 30 mumol/L) and weakly induced ABCB11, CYP2C19 and UGT1A3.	telaprevir	16-26	ATP binding cassette subfamily B member 11	Homo sapiens	113-119
24378332-5	2014	The effect of Ub(Delta)(GG) on BSEP internalization in these experiments was abrogated by treatment with chlorpromazine, an inhibitor of clathrin-mediated endocytosis, and the introduction of a Y1311A mutation into BSEP.	ub(delta)	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	31-35
24378332-5	2014	The effect of Ub(Delta)(GG) on BSEP internalization in these experiments was abrogated by treatment with chlorpromazine, an inhibitor of clathrin-mediated endocytosis, and the introduction of a Y1311A mutation into BSEP.	ub(delta)	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	215-219
24378332-5	2014	The effect of Ub(Delta)(GG) on BSEP internalization in these experiments was abrogated by treatment with chlorpromazine, an inhibitor of clathrin-mediated endocytosis, and the introduction of a Y1311A mutation into BSEP.	Chlorpromazine	105-119	ATP binding cassette subfamily B member 11	Homo sapiens	31-35
25392597-0	2014	The association between bile salt export pump single-nucleotide polymorphisms and primary biliary cirrhosis susceptibility and ursodeoxycholic acid response.	Ursodeoxycholic Acid	127-147	ATP binding cassette subfamily B member 11	Homo sapiens	24-45
24498134-9	2014	Similar to previously reported findings with sitaxsentan, BSEP inhibition was observed for bosentan and macitentan with IC50 values of 42 and 12 microM, respectively.	Bosentan	91-99	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
24498134-9	2014	Similar to previously reported findings with sitaxsentan, BSEP inhibition was observed for bosentan and macitentan with IC50 values of 42 and 12 microM, respectively.	macitentan	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
25392597-2	2014	Bile salt export pump (BSEP) is the predominant bile salt efflux system of hepatocytes.	Bile Acids and Salts	48-57	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
25392597-2	2014	Bile salt export pump (BSEP) is the predominant bile salt efflux system of hepatocytes.	Bile Acids and Salts	48-57	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
25392597-3	2014	BSEP gene has been attached great importance in the susceptibility of PBC and the response rate of ursodeoxycholic acid (UDCA) treatment of PBC patients.	Ursodeoxycholic Acid	99-119	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
23877105-0	2014	More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes.	candesartan cilexetil	57-78	ATP binding cassette subfamily B member 11	Homo sapiens	112-116
23877105-1	2014	Bile salt export pump (BSEP) plays a major role in biliary secretion of bile salts; therefore, drug-induced cholestasis could occur because of BSEP inhibition by drugs.	Bile Acids and Salts	72-82	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
23877105-1	2014	Bile salt export pump (BSEP) plays a major role in biliary secretion of bile salts; therefore, drug-induced cholestasis could occur because of BSEP inhibition by drugs.	Bile Acids and Salts	72-82	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
23877105-1	2014	Bile salt export pump (BSEP) plays a major role in biliary secretion of bile salts; therefore, drug-induced cholestasis could occur because of BSEP inhibition by drugs.	Bile Acids and Salts	72-82	ATP binding cassette subfamily B member 11	Homo sapiens	143-147
23877105-3	2014	In the present study, candesartan cilexetil (CIL) was used as a model compound and its inhibitory potential against BSEP was determined in sandwich-cultured human hepatocytes (hSCH) as well as in BSEP-expressing membrane vesicles.	candesartan cilexetil	22-43	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
23877105-3	2014	In the present study, candesartan cilexetil (CIL) was used as a model compound and its inhibitory potential against BSEP was determined in sandwich-cultured human hepatocytes (hSCH) as well as in BSEP-expressing membrane vesicles.	candesartan cilexetil	22-43	ATP binding cassette subfamily B member 11	Homo sapiens	196-200
24014644-2	2013	Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds, and 86 BSEP inhibitors were identified.	Taurocholic Acid	14-26	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
23877105-3	2014	In the present study, candesartan cilexetil (CIL) was used as a model compound and its inhibitory potential against BSEP was determined in sandwich-cultured human hepatocytes (hSCH) as well as in BSEP-expressing membrane vesicles.	CIL	45-48	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
23877105-4	2014	CIL exhibited potent BSEP inhibition with an IC50 value of 6.2 microM in the transport assay using membrane vesicles.	CIL	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
23877105-5	2014	In contrast, BSEP inhibition by CIL was not observed in hSCH after 120 min exposure.	CIL	32-35	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
23877105-6	2014	This discordance is possibly explained by metabolic elimination of CIL in hSCH because BSEP inhibition became reversely pronounced under the conditions where CIL metabolism was suppressed by diisopropyl fluorophosphates.	CIL	67-70	ATP binding cassette subfamily B member 11	Homo sapiens	87-91
23877105-6	2014	This discordance is possibly explained by metabolic elimination of CIL in hSCH because BSEP inhibition became reversely pronounced under the conditions where CIL metabolism was suppressed by diisopropyl fluorophosphates.	CIL	158-161	ATP binding cassette subfamily B member 11	Homo sapiens	87-91
23877105-6	2014	This discordance is possibly explained by metabolic elimination of CIL in hSCH because BSEP inhibition became reversely pronounced under the conditions where CIL metabolism was suppressed by diisopropyl fluorophosphates.	Isoflurophate	191-219	ATP binding cassette subfamily B member 11	Homo sapiens	87-91
23877105-7	2014	The results observed in hSCH are consistent with the fact that liver dysfunction or jaundice occurs with low frequency in clinical use of CIL, which may not be obtained by membrane vesicle study on the effect of CIL on BSEP.	CIL	212-215	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
25274209-2	2014	The bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and predominantly mediates the biliary excretion of bile salts.	Bile Acids and Salts	210-220	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
25274209-2	2014	The bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and predominantly mediates the biliary excretion of bile salts.	Bile Acids and Salts	210-220	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
25274209-2	2014	The bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and predominantly mediates the biliary excretion of bile salts.	Bile Acids and Salts	210-220	ATP binding cassette subfamily B member 11	Homo sapiens	32-38
25274209-5	2014	We have previously shown that in many cases of PFIC2 patients, the dysfunction of BSEP is attributable to decreased BSEP expression on the hepatocanalicular membrane and that 4-phenylbutyrate (4PB), an approved drug for urea cycle disorder, may be a compound with potential to restore BSEP expression.	4-phenylbutyric acid	175-191	ATP binding cassette subfamily B member 11	Homo sapiens	47-52
25274209-5	2014	We have previously shown that in many cases of PFIC2 patients, the dysfunction of BSEP is attributable to decreased BSEP expression on the hepatocanalicular membrane and that 4-phenylbutyrate (4PB), an approved drug for urea cycle disorder, may be a compound with potential to restore BSEP expression.	4-phenylbutyric acid	175-191	ATP binding cassette subfamily B member 11	Homo sapiens	82-86
24359682-1	2013	BACKGROUND: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile.	Bile Acids and Salts	100-110	ATP binding cassette subfamily B member 11	Homo sapiens	16-37
24359682-1	2013	BACKGROUND: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile.	Bile Acids and Salts	100-110	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
24359682-1	2013	BACKGROUND: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile.	Bile Acids and Salts	100-110	ATP binding cassette subfamily B member 11	Homo sapiens	44-50
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Bile Acids and Salts	112-121	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Bile Acids and Salts	112-121	ATP binding cassette subfamily B member 11	Homo sapiens	88-92
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Taurocholic Acid	122-138	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Taurocholic Acid	122-138	ATP binding cassette subfamily B member 11	Homo sapiens	88-92
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Taurocholic Acid	140-143	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Taurocholic Acid	140-143	ATP binding cassette subfamily B member 11	Homo sapiens	88-92
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Cholic Acid	127-138	ATP binding cassette subfamily B member 11	Homo sapiens	83-87
24359682-7	2013	Functional studies demonstrated for all species a tendency to a higher affinity of BSEP/Bsep for the conjugated bile acid taurocholic acid (TCA) than glycocholic acid (GCA), and a higher affinity for GCA than for the unconjugated cholic acid (CA).	Cholic Acid	127-138	ATP binding cassette subfamily B member 11	Homo sapiens	88-92
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Cyclosporine	47-61	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Troglitazone	63-75	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Troglitazone	63-75	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Ketoconazole	80-92	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Ketoconazole	80-92	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Taurocholic Acid	119-122	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
24359682-8	2013	The inhibitory potency of the model inhibitors cyclosporine A, troglitazone and ketoconazole was characterized against TCA uptake into BSEP/Bsep containing membrane vesicles.	Taurocholic Acid	119-122	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
24014644-2	2013	Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds, and 86 BSEP inhibitors were identified.	Taurocholic Acid	14-26	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
24014644-2	2013	Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds, and 86 BSEP inhibitors were identified.	Taurocholic Acid	28-30	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
24014644-2	2013	Inhibition of taurocholate (TA) transport was investigated in BSEP membrane vesicles for a data set of 250 compounds, and 86 BSEP inhibitors were identified.	Taurocholic Acid	28-30	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
24107776-5	2013	We have furthermore demonstrated that a factor in the SO lipid emulsions, stigmasterol, promotes cholestasis, liver injury, and liver macrophage activation in this model and that this effect may be mediated through suppression of canalicular bile transporter expression (Abcb11/BSEP, Abcc2/MRP2) via antagonism of the nuclear receptors Fxr and Lxr, and failure of up-regulation of the hepatic sterol exporters (Abcg5/g8/ABCG5/8).	Stigmasterol	74-86	ATP binding cassette subfamily B member 11	Homo sapiens	271-277
23758865-1	2013	BACKGROUND & AIMS: The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	27-48
23758865-1	2013	BACKGROUND & AIMS: The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	50-54
23758865-1	2013	BACKGROUND & AIMS: The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	56-62
23758865-1	2013	BACKGROUND & AIMS: The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells.	Bile Acids and Salts	27-36	ATP binding cassette subfamily B member 11	Homo sapiens	50-54
23758865-1	2013	BACKGROUND & AIMS: The bile salt export pump (BSEP, ABCB11) is essential for bile salt secretion at the canalicular membrane of liver cells.	Bile Acids and Salts	27-36	ATP binding cassette subfamily B member 11	Homo sapiens	56-62
23758865-3	2013	METHODS: The molecular basis of BSEP-associated liver disease in a sibling pair was characterized by immunostaining, gene sequencing, bile salt analysis and recombinant expression in mammalian cells and yeast for localization and in vitro activity studies respectively.	Bile Acids and Salts	134-143	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
24107776-5	2013	We have furthermore demonstrated that a factor in the SO lipid emulsions, stigmasterol, promotes cholestasis, liver injury, and liver macrophage activation in this model and that this effect may be mediated through suppression of canalicular bile transporter expression (Abcb11/BSEP, Abcc2/MRP2) via antagonism of the nuclear receptors Fxr and Lxr, and failure of up-regulation of the hepatic sterol exporters (Abcg5/g8/ABCG5/8).	Stigmasterol	74-86	ATP binding cassette subfamily B member 11	Homo sapiens	278-282
23707573-5	2013	Assay of 15d-PGJ2 regulation on hFXRalpha target genes revealed that treatment of HepG2 cells with 15d-PGJ2 resulted in the stimulation of mRNA expressions of bile-salt export pump (BSEP), and the decrease of cholesterol 7a-hydroxylase (CYP7a1).	15-deoxy-delta(12,14)-prostaglandin J2	9-17	ATP binding cassette subfamily B member 11	Homo sapiens	159-180
23701583-1	2013	BACKGROUND & AIMS: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	107-128
23701583-1	2013	BACKGROUND & AIMS: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
23701583-1	2013	BACKGROUND & AIMS: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	151-157
23750872-5	2013	In the older patient, bile salt export pump marking (encoded by ABCB11) was focally diminished.	Bile Acids and Salts	22-31	ATP binding cassette subfamily B member 11	Homo sapiens	64-70
23750872-6	2013	We hypothesized that AAS had either induced inhibition of normal ATP8B1/ABCB11 expression or triggered initial episodes of benign recurrent intrahepatic cholestasis (BRIC) type 1/or 2.	aas	21-24	ATP binding cassette subfamily B member 11	Homo sapiens	72-78
23707573-5	2013	Assay of 15d-PGJ2 regulation on hFXRalpha target genes revealed that treatment of HepG2 cells with 15d-PGJ2 resulted in the stimulation of mRNA expressions of bile-salt export pump (BSEP), and the decrease of cholesterol 7a-hydroxylase (CYP7a1).	15-deoxy-delta(12,14)-prostaglandin J2	99-107	ATP binding cassette subfamily B member 11	Homo sapiens	159-180
23707573-5	2013	Assay of 15d-PGJ2 regulation on hFXRalpha target genes revealed that treatment of HepG2 cells with 15d-PGJ2 resulted in the stimulation of mRNA expressions of bile-salt export pump (BSEP), and the decrease of cholesterol 7a-hydroxylase (CYP7a1).	15-deoxy-delta(12,14)-prostaglandin J2	99-107	ATP binding cassette subfamily B member 11	Homo sapiens	182-186
23876151-1	2013	Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid.	Bile Acids and Salts	202-211	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
23764895-2	2013	BSEP malfunction in humans causes bile acid retention and progressive liver injury, ultimately leading to end-stage liver failure.	Bile Acids and Salts	34-43	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
23750830-13	2013	Specifically, Rfree was above the 1.1 target threshold against UGT1A1, OATP1B1, and BSEP for atazanavir and indinavir.	Atazanavir Sulfate	93-103	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
23750830-13	2013	Specifically, Rfree was above the 1.1 target threshold against UGT1A1, OATP1B1, and BSEP for atazanavir and indinavir.	Indinavir	108-117	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
23750830-16	2013	These data suggest that the proposed surrogate probe substrates to evaluate the in vitro inhibition of UGT1A1, OATP1B1, and BSEP may be suitable to assess bilirubin disposition.	Bilirubin	155-164	ATP binding cassette subfamily B member 11	Homo sapiens	124-128
23695864-8	2013	Interaction of silibinin with MRP2 and BSEP was measured in vesicles isolated from Sf21 or Sf9 insect cells expressing these transporters using either estradiol-17beta-glucuronide or taurocholate as substrates.	Silybin	15-24	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
23588305-6	2013	The bile salt export pump (BSEP or ABCB11) prevents accumulation of toxic bile salt concentrations in hepatocytes, and BSEP inhibition or deficiency may cause cholestasis and liver injury.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
23588305-6	2013	The bile salt export pump (BSEP or ABCB11) prevents accumulation of toxic bile salt concentrations in hepatocytes, and BSEP inhibition or deficiency may cause cholestasis and liver injury.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
23588305-6	2013	The bile salt export pump (BSEP or ABCB11) prevents accumulation of toxic bile salt concentrations in hepatocytes, and BSEP inhibition or deficiency may cause cholestasis and liver injury.	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
23588305-6	2013	The bile salt export pump (BSEP or ABCB11) prevents accumulation of toxic bile salt concentrations in hepatocytes, and BSEP inhibition or deficiency may cause cholestasis and liver injury.	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
23750830-6	2013	However, because drug transporters also contribute to bilirubin elimination, the purpose of this work was to investigate the in vitro inhibition of OATP1B1, OATP1B3, MRP2, and BSEP of select test drugs known to elicit hyperbilirubinemia.	Bilirubin	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
23876151-1	2013	Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid.	Bile Acids and Salts	202-211	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
23876151-1	2013	Bile salt export pump (BSEP/ABCB11), a member of the family of ATP-binding cassette transporters, is localized on the canalicular membrane of hepatocytes and mediates the efficient biliary excretion of bile acid.	Bile Acids and Salts	202-211	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
23876151-2	2013	The secretion of bile acid into bile by BSEP provides the primary osmotic driving force for bile flow generation.	Bile Acids and Salts	17-26	ATP binding cassette subfamily B member 11	Homo sapiens	40-44
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Polysaccharides	9-24	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Polysaccharides	9-24	ATP binding cassette subfamily B member 11	Homo sapiens	163-167
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Water	104-109	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Water	104-109	ATP binding cassette subfamily B member 11	Homo sapiens	163-167
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Ethanol	131-138	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
24417139-4	2013	RESULTS: Extraction yield, sugar content and uronic acid content of BSEP-S was 1.56%, 80.56% and 3.33% , BSEP-C 1.18%, 80.79% and 5.47%, BSAP-S 1.58%, 86.50% and 3.79%, and BSAP-C 1.54%, 81.64% and 3.25%, respectively.	Uronic Acids	45-56	ATP binding cassette subfamily B member 11	Homo sapiens	68-72
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	174-196	ATP binding cassette subfamily B member 11	Homo sapiens	101-107
23583734-5	2013	Other variants of genes encoding transporters that affect the composition of bile have been associated with cholestasis, namely ABCB11, which encodes the bile salt export pump, and ABCB4, which encodes hepatocanalicular phosphatidylcholine floppase.	Bile Acids and Salts	154-163	ATP binding cassette subfamily B member 11	Homo sapiens	128-134
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	174-196	ATP binding cassette subfamily B member 11	Homo sapiens	127-148
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	174-196	ATP binding cassette subfamily B member 11	Homo sapiens	150-154
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	198-201	ATP binding cassette subfamily B member 11	Homo sapiens	101-107
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	198-201	ATP binding cassette subfamily B member 11	Homo sapiens	127-148
23446990-1	2013	Cholestasis with normal gamma glutamyl transferase characterizes functional deficiencies in the gene ABCB11, which encodes the bile salt export pump (BSEP), a liver-specific adenosine triphosphate (ATP)-binding cassette transporter.	Adenosine Triphosphate	198-201	ATP binding cassette subfamily B member 11	Homo sapiens	150-154
24421753-2	2013	Progressive familial intrahepatic cholestasis type II (PFIC2 and also called BSEP ((Bile Salt Export Pump)) deficiency) is an inherited disease that initiates end-stage liver cirrhosis which can predispose to HCC.	Bile Acids and Salts	84-93	ATP binding cassette subfamily B member 11	Homo sapiens	55-60
24421753-2	2013	Progressive familial intrahepatic cholestasis type II (PFIC2 and also called BSEP ((Bile Salt Export Pump)) deficiency) is an inherited disease that initiates end-stage liver cirrhosis which can predispose to HCC.	Bile Acids and Salts	84-93	ATP binding cassette subfamily B member 11	Homo sapiens	77-81
23462326-9	2013	The observed up-regulation of ABCB4, ABCB11, ABCC1, ABCC3, ABCC5, ABCC10, and ABCG2 in tumors may contribute to the generally poor treatment response of PDAC.	pdac	153-157	ATP binding cassette subfamily B member 11	Homo sapiens	37-43
22795478-1	2012	The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from hepatocytes into bile in humans.	Bile Acids and Salts	79-89	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
23175273-8	2013	Compared to CPZ effects, overloading of HepaRG cells with high concentrations of cholic and chenodeoxycholic acids induced a delayed oxidative stress and, similarly, after 24 hours it down-regulated BSEP and MDR3 in parallel to a decrease of NTCP and CYP8B1 and an increase of MRP4.	Cholic	81-87	ATP binding cassette subfamily B member 11	Homo sapiens	199-203
23175273-8	2013	Compared to CPZ effects, overloading of HepaRG cells with high concentrations of cholic and chenodeoxycholic acids induced a delayed oxidative stress and, similarly, after 24 hours it down-regulated BSEP and MDR3 in parallel to a decrease of NTCP and CYP8B1 and an increase of MRP4.	Chenodeoxycholic Acid	92-114	ATP binding cassette subfamily B member 11	Homo sapiens	199-203
23175273-9	2013	By contrast, low BA concentrations up-regulated BSEP and MDR3 in the absence of oxidative stress.	Bile Acids and Salts	17-19	ATP binding cassette subfamily B member 11	Homo sapiens	48-52
23213087-1	2013	UNLABELLED: As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis.	Bile Acids and Salts	29-38	ATP binding cassette subfamily B member 11	Homo sapiens	53-74
23213087-1	2013	UNLABELLED: As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis.	Bile Acids and Salts	29-38	ATP binding cassette subfamily B member 11	Homo sapiens	76-80
23213087-1	2013	UNLABELLED: As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	53-74
23213087-1	2013	UNLABELLED: As a canalicular bile acid effluxer, the bile salt export pump (BSEP) plays a vital role in maintaining bile acid homeostasis.	Bile Acids and Salts	116-125	ATP binding cassette subfamily B member 11	Homo sapiens	76-80
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily B member 11	Homo sapiens	267-271
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bilirubin	355-364	ATP binding cassette subfamily B member 11	Homo sapiens	272-278
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bile Acids and Salts	369-378	ATP binding cassette subfamily B member 11	Homo sapiens	267-271
24138031-7	2013	Indeed, closer in vitro examination employing transporter gene overexpressing MDCK cell lines and membrane vesicles revealed potent compound-dependent inhibition of human multi-drug resistance-associated protein 2 (MRP2/ABCC2; IC50 38 muM) and bile salt export pump (BSEP/ABCB11; IC50 10 muM), two crucial hepatobiliary transport proteins accountable for bilirubin and bile salt homeostasis, respectively.	Bile Acids and Salts	369-378	ATP binding cassette subfamily B member 11	Homo sapiens	272-278
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Bile Acids and Salts	56-65	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Bile Acids and Salts	56-65	ATP binding cassette subfamily B member 11	Homo sapiens	84-90
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Bile Acids and Salts	173-183	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Bile Acids and Salts	173-183	ATP binding cassette subfamily B member 11	Homo sapiens	84-90
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
23593265-1	2013	The human liver ATP-binding cassette (ABC) transporters bile salt export pump (BSEP/ABCB11) and the multidrug resistance protein 3 (MDR3/ABCB4) fulfill the translocation of bile salts and phosphatidylcholine across the apical membrane of hepatocytes.	Phosphatidylcholines	188-207	ATP binding cassette subfamily B member 11	Homo sapiens	84-90
23593265-8	2013	BSEP purified in n-dodecyl-beta-D-maltoside or Cymal-5 after solubilization with Fos-choline 16 from P. pastoris membranes showed binding to ATP-agarose.	dodecyl maltoside	17-43	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
23593265-8	2013	BSEP purified in n-dodecyl-beta-D-maltoside or Cymal-5 after solubilization with Fos-choline 16 from P. pastoris membranes showed binding to ATP-agarose.	Choline	85-92	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
23593265-8	2013	BSEP purified in n-dodecyl-beta-D-maltoside or Cymal-5 after solubilization with Fos-choline 16 from P. pastoris membranes showed binding to ATP-agarose.	ATP-sepharose	141-152	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
23213087-15	2013	Restoration of BSEP expression through suppressing inflammation in the liver may reestablish bile acid homeostasis.	Bile Acids and Salts	93-102	ATP binding cassette subfamily B member 11	Homo sapiens	15-19
23352986-5	2013	Some transporters such as OATP1B3 and the bile salt export pump (BSEP) were however down-regulated by atRA in primary human hepatocytes, but induced in HepaRG cells, thus pointing out discrepancies between these two liver cell models in terms of detoxifying protein regulation.	Tretinoin	102-106	ATP binding cassette subfamily B member 11	Homo sapiens	42-63
23352986-5	2013	Some transporters such as OATP1B3 and the bile salt export pump (BSEP) were however down-regulated by atRA in primary human hepatocytes, but induced in HepaRG cells, thus pointing out discrepancies between these two liver cell models in terms of detoxifying protein regulation.	Tretinoin	102-106	ATP binding cassette subfamily B member 11	Homo sapiens	65-69
23437912-10	2013	We further speculate that the ABCB11 mutations do not prevent BSEP glycoprotein to be expressed at the canalicular pole of hepatocytes, but interfere with its ability to export bile salts.	Bile Acids and Salts	177-187	ATP binding cassette subfamily B member 11	Homo sapiens	30-36
24081232-6	2013	CONCLUSIONS: This study, the largest to date on genetic predictors of weight loss and regain, indicates that SNPs within ABCB11, related to bile salt transfer, and TNFRSF11A, implicated in adipose tissue physiology, predict the magnitude of weight loss during behavioral intervention.	Bile Acids and Salts	140-149	ATP binding cassette subfamily B member 11	Homo sapiens	121-127
22795478-1	2012	The bile salt export pump (BSEP) is the major transporter for the secretion of bile acids from hepatocytes into bile in humans.	Bile Acids and Salts	79-89	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
22673116-4	2012	Following dosing with troglitazone, there was a loss of the large lipid droplets in the human hepatocytes, a decrease in the amount of lipid as observed in frozen sections of liver stained by Oil-red-O, and a decrease in the expression of two bile acid transporters, BSEP and MRP2.	Troglitazone	22-34	ATP binding cassette subfamily B member 11	Homo sapiens	267-271
22961681-1	2012	The human bile salt export pump (BSEP) is a membrane protein expressed on the canalicular plasma membrane domain of hepatocytes, which mediates active transport of unconjugated and conjugated bile salts from liver cells into bile.	Bile Acids and Salts	192-202	ATP binding cassette subfamily B member 11	Homo sapiens	10-31
22961681-1	2012	The human bile salt export pump (BSEP) is a membrane protein expressed on the canalicular plasma membrane domain of hepatocytes, which mediates active transport of unconjugated and conjugated bile salts from liver cells into bile.	Bile Acids and Salts	192-202	ATP binding cassette subfamily B member 11	Homo sapiens	33-37
25755453-7	2012	The difference can be explained by lower mRNA expression of the transporter proteins sodium taurocholate cotransporting polypeptide (NTCP) and bile salt export pump (BSEP; ABCB11) when cultured in DMEM.	dmem	197-201	ATP binding cassette subfamily B member 11	Homo sapiens	143-164
25755453-7	2012	The difference can be explained by lower mRNA expression of the transporter proteins sodium taurocholate cotransporting polypeptide (NTCP) and bile salt export pump (BSEP; ABCB11) when cultured in DMEM.	dmem	197-201	ATP binding cassette subfamily B member 11	Homo sapiens	166-170
25755453-7	2012	The difference can be explained by lower mRNA expression of the transporter proteins sodium taurocholate cotransporting polypeptide (NTCP) and bile salt export pump (BSEP; ABCB11) when cultured in DMEM.	dmem	197-201	ATP binding cassette subfamily B member 11	Homo sapiens	172-178
25755453-9	2012	Following extended time in culture supplementation of Williams" medium E with dexamethasone increased the expression of NTCP and BSEP.	Dexamethasone	78-91	ATP binding cassette subfamily B member 11	Homo sapiens	129-133
25755453-11	2012	Supplementation with dexamethasone increase mRNA levels of NTCP and BSEP.	Dexamethasone	21-34	ATP binding cassette subfamily B member 11	Homo sapiens	68-72
22120137-1	2012	Bile salt export pump (BSEP, ABC11) is a membrane protein that is localized in the cholesterol-rich canalicular membrane of hepatocytes.	Cholesterol	83-94	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
22120137-1	2012	Bile salt export pump (BSEP, ABC11) is a membrane protein that is localized in the cholesterol-rich canalicular membrane of hepatocytes.	Cholesterol	83-94	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
22120137-4	2012	Mutations of BSEP result in a genetic disease, called progressive familial intrahepatic cholestasis type 2 (PFIC2), that is characterized with decreased biliary bile salt secretion, leading to decreased bile flow and accumulation of bile salts inside the hepatocyte, inflicting damage.	Bile Acids and Salts	161-170	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
22120137-4	2012	Mutations of BSEP result in a genetic disease, called progressive familial intrahepatic cholestasis type 2 (PFIC2), that is characterized with decreased biliary bile salt secretion, leading to decreased bile flow and accumulation of bile salts inside the hepatocyte, inflicting damage.	Bile Acids and Salts	161-170	ATP binding cassette subfamily B member 11	Homo sapiens	108-113
22583617-0	2012	E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.	GW 4064	75-81	ATP binding cassette subfamily B member 11	Homo sapiens	14-35
22120137-4	2012	Mutations of BSEP result in a genetic disease, called progressive familial intrahepatic cholestasis type 2 (PFIC2), that is characterized with decreased biliary bile salt secretion, leading to decreased bile flow and accumulation of bile salts inside the hepatocyte, inflicting damage.	Bile Acids and Salts	233-243	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
22120137-4	2012	Mutations of BSEP result in a genetic disease, called progressive familial intrahepatic cholestasis type 2 (PFIC2), that is characterized with decreased biliary bile salt secretion, leading to decreased bile flow and accumulation of bile salts inside the hepatocyte, inflicting damage.	Bile Acids and Salts	233-243	ATP binding cassette subfamily B member 11	Homo sapiens	108-113
22120137-5	2012	BSEP inhibitor drugs produce similar bile salt retention that may lead to severe cholestasis and liver damage.	Bile Acids and Salts	37-46	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
22120137-8	2012	Although several methods are suitable to detect BSEP-drug interactions, due to interspecies differences in bile acid composition, differences in hepatobiliary transporter modulation, they have limitations.	Bile Acids and Salts	107-116	ATP binding cassette subfamily B member 11	Homo sapiens	48-52
23169269-2	2012	Probably the two most important proteins at this location are MRP2 and BSEP, which transport phase II conjugates of xenobiotics and endobiotics and conjugated bile salts, respectively.	Bile Acids and Salts	159-169	ATP binding cassette subfamily B member 11	Homo sapiens	71-75
23169269-4	2012	Conjugated bile salts and phase II metabolites are compounds with low passive permeability; therefore, the most commonly used test system to investigate MRP2- and BSEP-mediated transport processes is the vesicular transport assay.	Bile Acids and Salts	11-21	ATP binding cassette subfamily B member 11	Homo sapiens	163-167
23342360-7	2012	Fibrosis progression has been associated with variants of Vitamin D receptor (VDR) and ABCB11 (bile salt export pump).	Bile Acids and Salts	95-104	ATP binding cassette subfamily B member 11	Homo sapiens	87-93
22609309-1	2012	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	77-82
22609309-1	2012	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	107-113
22609309-1	2012	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	139-160
22609309-1	2012	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	162-166
22609309-4	2012	After an in vitro study in a hepatocellular polarized line, we tested 4-PB treatment in a child with a homozygous p.T1210P BSEP mutation.	4-phenylbutyric acid	70-74	ATP binding cassette subfamily B member 11	Homo sapiens	123-127
22609309-9	2012	4-PB as well as incubation at 27 C partially corrected Bsep(T1210P)-GFP targeting to the canalicular membrane, while combined treatments resulted in normal canalicular localization.	4-phenylbutyric acid	0-4	ATP binding cassette subfamily B member 11	Homo sapiens	66-71
22609309-11	2012	Also, canalicular expression of p.T1210P BSEP mutant was partially corrected as was biliary bile acid excretion.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
22609309-12	2012	CONCLUSIONS: The results illustrate for the first time the therapeutic potential of a clinically approved chaperone drug in a selected patient with PFIC2 and support that bile secretion improvement might be due to the ability of 4-PB to retarget mutated BSEP.	4-phenylbutyric acid	229-233	ATP binding cassette subfamily B member 11	Homo sapiens	148-153
22609309-12	2012	CONCLUSIONS: The results illustrate for the first time the therapeutic potential of a clinically approved chaperone drug in a selected patient with PFIC2 and support that bile secretion improvement might be due to the ability of 4-PB to retarget mutated BSEP.	4-phenylbutyric acid	229-233	ATP binding cassette subfamily B member 11	Homo sapiens	254-258
22522591-1	2012	Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD).	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	97-118
22522591-1	2012	Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD).	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	120-124
22522591-1	2012	Increased serum bile salt levels have been associated to a single-nucleotide polymorphism in the bile salt export pump (BSEP; ABCB11) in several acquired cholestatic liver diseases but there is little evidence in alcoholic liver disease (ALD).	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	126-132
22583617-1	2012	Bile salt export pump (BSEP) is a member of the ATP-binding cassette transmembrane transporter family and mediates biliary excretion of bile acids from hepatocytes.	Bile Acids and Salts	136-146	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
22583617-1	2012	Bile salt export pump (BSEP) is a member of the ATP-binding cassette transmembrane transporter family and mediates biliary excretion of bile acids from hepatocytes.	Bile Acids and Salts	136-146	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
22583617-3	2012	We previously found that compounds based on GW4064, a representative farnesoid X receptor (FXR) agonist, enhanced E297G BSEP transport activity.	GW 4064	44-50	ATP binding cassette subfamily B member 11	Homo sapiens	120-124
22583617-4	2012	Here, we conducted a structure-activity relationship analysis of GW4064 derivatives aimed at separating E297G BSEP-function-promoting activity and FXR-agonistic activity.	GW 4064	65-71	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
22583617-5	2012	Among newly synthesized reversed-amide derivatives of previously reported GW4064 analogs 2a-2f, we identified 7c as a selective BSEP function enhancer.	Amides	33-38	ATP binding cassette subfamily B member 11	Homo sapiens	128-132
22583617-5	2012	Among newly synthesized reversed-amide derivatives of previously reported GW4064 analogs 2a-2f, we identified 7c as a selective BSEP function enhancer.	GW 4064	74-80	ATP binding cassette subfamily B member 11	Homo sapiens	128-132
22583617-5	2012	Among newly synthesized reversed-amide derivatives of previously reported GW4064 analogs 2a-2f, we identified 7c as a selective BSEP function enhancer.	7C	110-112	ATP binding cassette subfamily B member 11	Homo sapiens	128-132
22583617-0	2012	E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity.	GW 4064	75-81	ATP binding cassette subfamily B member 11	Homo sapiens	37-41
22161577-10	2012	CONCLUSION: Our results indicate that constitutive internalization of BSEP is clathrin-mediated and dependent on the tyrosine-based endocytic motif at the C-terminal end of BSEP.	Tyrosine	117-125	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
22681771-1	2012	BACKGROUND: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.	Bile Acids and Salts	93-102	ATP binding cassette subfamily B member 11	Homo sapiens	22-66
22681771-1	2012	BACKGROUND: The human ATP-binding cassette, subfamily B, member 11 (ABCB11) gene encodes the bile salt export pump, which is exclusively expressed at the canalicular membrane of hepatocytes.	Bile Acids and Salts	93-102	ATP binding cassette subfamily B member 11	Homo sapiens	68-74
22161577-10	2012	CONCLUSION: Our results indicate that constitutive internalization of BSEP is clathrin-mediated and dependent on the tyrosine-based endocytic motif at the C-terminal end of BSEP.	Tyrosine	117-125	ATP binding cassette subfamily B member 11	Homo sapiens	173-177
22161577-0	2012	A C-terminal tyrosine-based motif in the bile salt export pump directs clathrin-dependent endocytosis.	Tyrosine	13-21	ATP binding cassette subfamily B member 11	Homo sapiens	41-62
22161577-1	2012	UNLABELLED: The liver-specific bile salt export pump (BSEP) is crucial for bile acid-dependent bile flow at the apical membrane.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	31-52
22262466-1	2012	UNLABELLED: The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis.	Bile Acids and Salts	79-89	ATP binding cassette subfamily B member 11	Homo sapiens	16-37
22089923-9	2012	BACL is essential for reconjugation of bile acids deconjugated by gut bacteria, and BSEP is essential for hepatocyte-canaliculus export of conjugated bile acids.	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
22262466-1	2012	UNLABELLED: The bile salt export pump (BSEP) mediates the biliary excretion of bile salts and its dysfunction induces intrahepatic cholestasis.	Bile Acids and Salts	79-89	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
22262466-4	2012	We have shown previously that 4-phenylbutyrate (4PBA), a drug used for ornithine transcarbamylase deficiency (OTCD), inhibited internalization and subsequent degradation of cell-surface-resident BSEP.	4-phenylbutyric acid	30-46	ATP binding cassette subfamily B member 11	Homo sapiens	195-199
22262466-8	2012	Studies using immunostaining, coimmunoprecipitation, glutathione S-transferase pulldown assay, and time-lapse imaging show that AP2 interacts with BSEP at the CM through a tyrosine motif at the carboxyl terminus of BSEP and mediates BSEP internalization from the CM of hepatocytes.	Glutathione	53-64	ATP binding cassette subfamily B member 11	Homo sapiens	147-151
22262466-8	2012	Studies using immunostaining, coimmunoprecipitation, glutathione S-transferase pulldown assay, and time-lapse imaging show that AP2 interacts with BSEP at the CM through a tyrosine motif at the carboxyl terminus of BSEP and mediates BSEP internalization from the CM of hepatocytes.	Tyrosine	172-180	ATP binding cassette subfamily B member 11	Homo sapiens	147-151
22161577-1	2012	UNLABELLED: The liver-specific bile salt export pump (BSEP) is crucial for bile acid-dependent bile flow at the apical membrane.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	54-58
22161577-2	2012	BSEP, a member of the family of structurally related adenosine triphosphate (ATP)-binding cassette (ABC) proteins, is composed of 12 transmembrane segments (TMS) and two large cytoplasmic nucleotide-binding domains (NBDs).	Adenosine Triphosphate	53-75	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
22161577-2	2012	BSEP, a member of the family of structurally related adenosine triphosphate (ATP)-binding cassette (ABC) proteins, is composed of 12 transmembrane segments (TMS) and two large cytoplasmic nucleotide-binding domains (NBDs).	Adenosine Triphosphate	77-80	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
22464344-2	2012	4-Phenylbutyric acid (4-PBA) enhances the cell surface expression and transport capacity of E297G BSEP, but has a relatively high dose (1mM or more) is required to show the effect.	4-phenylbutyric acid	0-20	ATP binding cassette subfamily B member 11	Homo sapiens	98-102
22464344-2	2012	4-Phenylbutyric acid (4-PBA) enhances the cell surface expression and transport capacity of E297G BSEP, but has a relatively high dose (1mM or more) is required to show the effect.	4-phenylbutyric acid	22-27	ATP binding cassette subfamily B member 11	Homo sapiens	98-102
22464344-3	2012	Here, we show that bile acids possibly act as pharmacological chaperones, promoting the proper folding and trafficking of E297G BSEP.	Bile Acids and Salts	19-29	ATP binding cassette subfamily B member 11	Homo sapiens	128-132
22859919-2	2012	Secretion of bile salts by ABCB11 is essential for bile flow and for absorption of lipids and fat-soluble vitamins.	Bile Acids and Salts	13-23	ATP binding cassette subfamily B member 11	Homo sapiens	27-33
22675952-1	2012	Obstetric cholestasis (OC) is a cholestatic disorder with a prominent genetic background including variation in diverse hepatobiliary lipid transporters, such as ABCB4 (phospholipids) and ABCB11 (bile salts).	Bile Acids and Salts	196-206	ATP binding cassette subfamily B member 11	Homo sapiens	188-194
22246918-0	2012	Hypolipidemic agent Z-guggulsterone: metabolism interplays with induction of carboxylesterase and bile salt export pump.	pregna-4,17-diene-3,16-dione	20-35	ATP binding cassette subfamily B member 11	Homo sapiens	98-119
22246918-7	2012	Instead, this phytosterol significantly induced CES1 and BSEP through transactivation.	Phytosterols	14-25	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
22246918-8	2012	Z-Guggulsterone underwent metabolism by CYP3A4, and the metabolites greatly increased the induction potency on BSEP but not on CES1.	pregna-4,17-diene-3,16-dione	0-15	ATP binding cassette subfamily B member 11	Homo sapiens	111-115
22246918-9	2012	BSEP induction favors cholesterol elimination, whereas CES1 involves both elimination and retention (probably when excessively induced).	Cholesterol	22-33	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
21984474-3	2012	They are synthesized from cholesterol in the hepatocyte and their secretion by the bile salt export pump (BSEP or ABCB11) drives bile flow and is the starting point for the enterohepatic cycle.	Cholesterol	26-37	ATP binding cassette subfamily B member 11	Homo sapiens	83-104
21984474-3	2012	They are synthesized from cholesterol in the hepatocyte and their secretion by the bile salt export pump (BSEP or ABCB11) drives bile flow and is the starting point for the enterohepatic cycle.	Cholesterol	26-37	ATP binding cassette subfamily B member 11	Homo sapiens	106-110
21984474-3	2012	They are synthesized from cholesterol in the hepatocyte and their secretion by the bile salt export pump (BSEP or ABCB11) drives bile flow and is the starting point for the enterohepatic cycle.	Cholesterol	26-37	ATP binding cassette subfamily B member 11	Homo sapiens	114-120
22108051-0	2011	Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.	Bile Acids and Salts	53-62	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
22098322-6	2012	RESULTS: Patients with low post-operative bilirubin had lower levels of NTCP, MDR3 and BSEP mRNA compared to those with high bilirubin after Pringle manoeuvre.	Bilirubin	42-51	ATP binding cassette subfamily B member 11	Homo sapiens	87-91
22291955-6	2012	Exposure of HepG2 cells to theonellasterol antagonizes the effect of natural and synthetic FXR agonists on FXR-regulated genes, including SHP, OSTalpha, BSEP and MRP4.	7-hydroxytheonellasterol	27-42	ATP binding cassette subfamily B member 11	Homo sapiens	153-157
22044429-3	2011	EPSS was measured using bedside ultrasonography by junior EPs (PGY 3 and PGY 4 residents) with variable ultrasound experience.	epss	0-4	ATP binding cassette subfamily B member 11	Homo sapiens	73-78
20723035-12	2011	The higher allelic frequency of ABCB11 1331C in HCV-patients compared to controls may indirectly link increased BA to HCV chronicity.	Bile Acids and Salts	112-114	ATP binding cassette subfamily B member 11	Homo sapiens	32-38
21649640-0	2011	Scoparone potentiates transactivation of the bile salt export pump gene and this effect is enhanced by cytochrome P450 metabolism but abolished by a PKC inhibitor.	scoparone	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	45-66
21649640-5	2011	In addition, the expression of the bile salt export pump (BSEP), a transporter of bile acids, was determined.	Bile Acids and Salts	82-92	ATP binding cassette subfamily B member 11	Homo sapiens	35-56
21649640-5	2011	In addition, the expression of the bile salt export pump (BSEP), a transporter of bile acids, was determined.	Bile Acids and Salts	82-92	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
21649640-8	2011	The activation of the human BSEP promoter reporter by scoparone was determined in Huh7 cells by transient transfection and in mice by bioluminescent imaging.	scoparone	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	28-32
21649640-11	2011	However, scoparone significantly potentiated the expression of BSEP induced by CDCA.	scoparone	9-18	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
21649640-11	2011	However, scoparone significantly potentiated the expression of BSEP induced by CDCA.	Chenodeoxycholic Acid	79-83	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
21649640-12	2011	Consistent with this, scoparone potentiated the stimulant effect of CDCA on the human BSEP promoter.	scoparone	22-31	ATP binding cassette subfamily B member 11	Homo sapiens	86-90
21649640-12	2011	Consistent with this, scoparone potentiated the stimulant effect of CDCA on the human BSEP promoter.	Chenodeoxycholic Acid	68-72	ATP binding cassette subfamily B member 11	Homo sapiens	86-90
21526375-6	2011	The beneficial properties of rifampicin were associated with an increase in DME and export bile acid systems (multidrug resistance-associated protein 4, MRP4, and bile acid export pump to bile duct, BSEP) expression, as well as a reduction in NTCP expression.	Rifampin	29-39	ATP binding cassette subfamily B member 11	Homo sapiens	199-203
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	190-199	ATP binding cassette subfamily B member 11	Homo sapiens	212-216
21811948-3	2011	Mutations in the ABCB11 gene, encoding the bile salt export pump, can entail progressive familial intrahepatic cholestasis and benign recurred intrahepatic cholestasis.	Bile Acids and Salts	43-52	ATP binding cassette subfamily B member 11	Homo sapiens	17-23
21811948-8	2011	Genetic analysis showed the compound heterozygous variants ABCB11 A 444V and 3084A > G. Treatment with ursodesoxycholic acid and intermittent therapy with prednisone reduced pruritus and jaundice with concomitant improvement of blood test.	Ursodeoxycholic Acid	106-127	ATP binding cassette subfamily B member 11	Homo sapiens	59-65
21811948-8	2011	Genetic analysis showed the compound heterozygous variants ABCB11 A 444V and 3084A > G. Treatment with ursodesoxycholic acid and intermittent therapy with prednisone reduced pruritus and jaundice with concomitant improvement of blood test.	Prednisone	158-168	ATP binding cassette subfamily B member 11	Homo sapiens	59-65
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	190-199	ATP binding cassette subfamily B member 11	Homo sapiens	218-224
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	252-261	ATP binding cassette subfamily B member 11	Homo sapiens	212-216
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	252-261	ATP binding cassette subfamily B member 11	Homo sapiens	218-224
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	278-287	ATP binding cassette subfamily B member 11	Homo sapiens	212-216
22139880-3	2011	Genetic variants in humans and genetic knockout in rodents, or transporter inhibition have indicated that both the conjugate export pump MRP2 (multidrug resistance protein 2; ABCC2) and the bile salt export pump BSEP (ABCB11) are major contributors to bile acid-independent and bile acid-dependent bile flow, respectively.	Bile Acids and Salts	278-287	ATP binding cassette subfamily B member 11	Homo sapiens	218-224
21039337-0	2011	The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target.	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	38-42
21501604-8	2011	50 muM bosentan up-regulated e.g. CYP3A4 8.5-fold, ABCB1 5.1-fold, and ABCB11 1.9-fold at the mRNA level in LS180 cells.	Bosentan	7-15	ATP binding cassette subfamily B member 11	Homo sapiens	71-77
21039337-6	2011	Bile salts are secreted from hepatocytes into the bile by the bile salt export pump BSEP.	Bile Acids and Salts	62-71	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
21039337-8	2011	Improper functioning of BSEP leads to an accumulation of bile salts within hepatocytes, where bile salts become cytotoxic.	Bile Acids and Salts	57-67	ATP binding cassette subfamily B member 11	Homo sapiens	24-28
21039337-0	2011	The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target.	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	44-50
21039337-8	2011	Improper functioning of BSEP leads to an accumulation of bile salts within hepatocytes, where bile salts become cytotoxic.	Bile Acids and Salts	94-104	ATP binding cassette subfamily B member 11	Homo sapiens	24-28
21039337-6	2011	Bile salts are secreted from hepatocytes into the bile by the bile salt export pump BSEP.	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
20883210-12	2011	The common ABCB11 1331CC genotype, which is present in 40% of HCV patients and renders the carrier susceptible to increased bile acid levels, is associated with cirrhosis.	Bile Acids and Salts	124-133	ATP binding cassette subfamily B member 11	Homo sapiens	11-17
21320040-3	2011	The bile salt export pump (BSEP) (ABCB11) is the key export system for bile salts from hepatocytes.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
21087209-2	2011	In the present issue of Clinical Science, Iwata and co-workers report an association between a variant of a gene regulating bile acid levels, ABCB11 1331T>C (where ABCB11 encodes ATP-binding cassette, subfamily B, member 11), and the progression to cirrhosis in patients with HCV, but not in fatty liver patients.	Bile Acids and Salts	124-133	ATP binding cassette subfamily B member 11	Homo sapiens	142-148
21087209-2	2011	In the present issue of Clinical Science, Iwata and co-workers report an association between a variant of a gene regulating bile acid levels, ABCB11 1331T>C (where ABCB11 encodes ATP-binding cassette, subfamily B, member 11), and the progression to cirrhosis in patients with HCV, but not in fatty liver patients.	Bile Acids and Salts	124-133	ATP binding cassette subfamily B member 11	Homo sapiens	167-173
21087209-2	2011	In the present issue of Clinical Science, Iwata and co-workers report an association between a variant of a gene regulating bile acid levels, ABCB11 1331T>C (where ABCB11 encodes ATP-binding cassette, subfamily B, member 11), and the progression to cirrhosis in patients with HCV, but not in fatty liver patients.	Bile Acids and Salts	124-133	ATP binding cassette subfamily B member 11	Homo sapiens	182-226
21320040-3	2011	The bile salt export pump (BSEP) (ABCB11) is the key export system for bile salts from hepatocytes.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
21320040-3	2011	The bile salt export pump (BSEP) (ABCB11) is the key export system for bile salts from hepatocytes.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	34-40
21320040-4	2011	AREAS COVERED: This article provides an introduction into the physiology of bile formation followed by a summary of the current knowledge on the key bile salt transporters, namely, the sodium-taurocholate co-transporting polypeptide NTCP, the organic anion transporting polypeptides (OATPs), BSEP and the multi-drug resistance protein 3.	Taurocholic Acid	185-204	ATP binding cassette subfamily B member 11	Homo sapiens	292-296
21219577-4	2011	Genetic testing of each patient revealed two missense mutations of the bile salt export pump, S901R and C1083Y, which have not previously been associated with PFIC-2.	Bile Acids and Salts	71-80	ATP binding cassette subfamily B member 11	Homo sapiens	159-165
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Bile Acids and Salts	21-31	ATP binding cassette subfamily B member 11	Homo sapiens	154-158
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Bile Acids and Salts	21-31	ATP binding cassette subfamily B member 11	Homo sapiens	159-165
21056966-5	2011	In contrast, BSEP-mediated transport of [3H]taurocholate was not significantly affected by ITZ, which is consistent with our in vivo observations.	[3h]taurocholate	40-56	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Phospholipids	36-49	ATP binding cassette subfamily B member 11	Homo sapiens	154-158
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Phospholipids	36-49	ATP binding cassette subfamily B member 11	Homo sapiens	159-165
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Bile Acids and Salts	131-140	ATP binding cassette subfamily B member 11	Homo sapiens	154-158
21056966-1	2011	Biliary secretion of bile acids and phospholipids, both of which are essential components of biliary micelles, are mediated by the bile salt export pump (BSEP/ABCB11) and multidrug resistance 3 P-glycoprotein (MDR3/ABCB4), respectively, and their genetic dysfunction leads to the acquisition of severe cholestatic diseases.	Bile Acids and Salts	131-140	ATP binding cassette subfamily B member 11	Homo sapiens	159-165
20606004-6	2010	In vitro biliary excretion of micafungin was reduced by 80 and 75% in the presence of the bile salt export pump (BSEP) inhibitors taurocholate (100 muM) and nefazodone (25 muM), respectively.	Micafungin	30-40	ATP binding cassette subfamily B member 11	Homo sapiens	90-111
21103971-10	2011	Canalicular export of bile salts is mediated by the ATP-binding cassette transporter bile salt export pump BSEP (ABCB11).	Bile Acids and Salts	22-32	ATP binding cassette subfamily B member 11	Homo sapiens	85-106
21103971-10	2011	Canalicular export of bile salts is mediated by the ATP-binding cassette transporter bile salt export pump BSEP (ABCB11).	Bile Acids and Salts	22-32	ATP binding cassette subfamily B member 11	Homo sapiens	107-111
21103971-10	2011	Canalicular export of bile salts is mediated by the ATP-binding cassette transporter bile salt export pump BSEP (ABCB11).	Bile Acids and Salts	22-32	ATP binding cassette subfamily B member 11	Homo sapiens	113-119
21103971-11	2011	BSEP constitutes the rate limiting step of hepatocellular bile salt transport and drives enterohepatic circulation of bile salts.	Bile Acids and Salts	58-67	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
21103971-11	2011	BSEP constitutes the rate limiting step of hepatocellular bile salt transport and drives enterohepatic circulation of bile salts.	Bile Acids and Salts	118-128	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
21103971-14	2011	The substrates of BSEP are practically restricted to bile salts and their metabolites.	Bile Acids and Salts	53-63	ATP binding cassette subfamily B member 11	Homo sapiens	18-22
21055686-4	2010	Demonstrating BSEP expression can direct attention to bile acid synthesis disorders.	Bile Acids and Salts	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	14-18
21195340-3	2011	AMPK enhances the expression of the bile acid transporter, BSEP, by activating the coactivator SRC-2, thus promoting bile acid secretion.	Bile Acids and Salts	36-45	ATP binding cassette subfamily B member 11	Homo sapiens	59-63
21195347-5	2011	This defect can be attributed to AMPK- and SRC-2-mediated transcriptional regulation of hepatic bile acid (BA) secretion into the gut, as it can be completely rescued by replenishing intestinal BA or by genetically restoring the levels of hepatic bile salt export pump (BSEP).	Bile Acids and Salts	96-105	ATP binding cassette subfamily B member 11	Homo sapiens	247-268
21195347-5	2011	This defect can be attributed to AMPK- and SRC-2-mediated transcriptional regulation of hepatic bile acid (BA) secretion into the gut, as it can be completely rescued by replenishing intestinal BA or by genetically restoring the levels of hepatic bile salt export pump (BSEP).	Bile Acids and Salts	96-105	ATP binding cassette subfamily B member 11	Homo sapiens	270-274
21195347-5	2011	This defect can be attributed to AMPK- and SRC-2-mediated transcriptional regulation of hepatic bile acid (BA) secretion into the gut, as it can be completely rescued by replenishing intestinal BA or by genetically restoring the levels of hepatic bile salt export pump (BSEP).	Bile Acids and Salts	107-109	ATP binding cassette subfamily B member 11	Homo sapiens	247-268
21195347-5	2011	This defect can be attributed to AMPK- and SRC-2-mediated transcriptional regulation of hepatic bile acid (BA) secretion into the gut, as it can be completely rescued by replenishing intestinal BA or by genetically restoring the levels of hepatic bile salt export pump (BSEP).	Bile Acids and Salts	107-109	ATP binding cassette subfamily B member 11	Homo sapiens	270-274
21691112-1	2011	The bile salt export pump (BSEP, ABCB11) is the major transporter protein for the excretion of bile salts into bile.	Bile Acids and Salts	95-105	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
21691112-1	2011	The bile salt export pump (BSEP, ABCB11) is the major transporter protein for the excretion of bile salts into bile.	Bile Acids and Salts	95-105	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
21691112-1	2011	The bile salt export pump (BSEP, ABCB11) is the major transporter protein for the excretion of bile salts into bile.	Bile Acids and Salts	95-105	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
21691112-2	2011	Here we describe a spectrum of BSEP-dependent effects on the course of liver diseases, and present two mutations that differentially affect total bile acid output and the biliary bile acid profile.	Bile Acids and Salts	146-155	ATP binding cassette subfamily B member 11	Homo sapiens	31-35
21691112-2	2011	Here we describe a spectrum of BSEP-dependent effects on the course of liver diseases, and present two mutations that differentially affect total bile acid output and the biliary bile acid profile.	Bile Acids and Salts	179-188	ATP binding cassette subfamily B member 11	Homo sapiens	31-35
21691112-4	2011	On the other hand, the common BSEP polymorphism V444A (c.1331T>C; allele frequency 65%) emerged as an independent predictor of the success rate in patients with chronic hepatitis C treated with pegylated interferon/ribavirin.	Ribavirin	218-227	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
21157969-5	2010	Next to the established ATP-binding cassette (ABC) transporters mediating the biliary secretion of bile acids (ABCB11), phospholipids (ABCB4) and cholesterol (ABCG5/G8), special attention is given to emerging proteins that modulate or mediate biliary cholesterol secretion.	Bile Acids and Salts	99-109	ATP binding cassette subfamily B member 11	Homo sapiens	111-117
20829430-5	2010	Unfortunately, preclinical animal models have been poor predictors of the liver injury associated with BSEP interference observed for humans, possibly because of interspecies differences in bile acid composition, differences in hepatobiliary transporter modulation or constitutive expression, as well as other mechanisms.	Bile Acids and Salts	190-199	ATP binding cassette subfamily B member 11	Homo sapiens	103-107
20800306-1	2010	BACKGROUND & AIMS: PFIC2 is caused by mutations in ABCB11 encoding BSEP.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	23-28
20800306-1	2010	BACKGROUND & AIMS: PFIC2 is caused by mutations in ABCB11 encoding BSEP.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	55-61
20800306-1	2010	BACKGROUND & AIMS: PFIC2 is caused by mutations in ABCB11 encoding BSEP.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	71-75
20606004-6	2010	In vitro biliary excretion of micafungin was reduced by 80 and 75% in the presence of the bile salt export pump (BSEP) inhibitors taurocholate (100 muM) and nefazodone (25 muM), respectively.	Micafungin	30-40	ATP binding cassette subfamily B member 11	Homo sapiens	113-117
20606004-6	2010	In vitro biliary excretion of micafungin was reduced by 80 and 75% in the presence of the bile salt export pump (BSEP) inhibitors taurocholate (100 muM) and nefazodone (25 muM), respectively.	Taurocholic Acid	130-142	ATP binding cassette subfamily B member 11	Homo sapiens	90-111
20606004-6	2010	In vitro biliary excretion of micafungin was reduced by 80 and 75% in the presence of the bile salt export pump (BSEP) inhibitors taurocholate (100 muM) and nefazodone (25 muM), respectively.	Taurocholic Acid	130-142	ATP binding cassette subfamily B member 11	Homo sapiens	113-117
20606004-6	2010	In vitro biliary excretion of micafungin was reduced by 80 and 75% in the presence of the bile salt export pump (BSEP) inhibitors taurocholate (100 muM) and nefazodone (25 muM), respectively.	nefazodone	157-167	ATP binding cassette subfamily B member 11	Homo sapiens	113-117
20606004-9	2010	These results suggest that NTCP/Ntcp and BSEP/Bsep are primarily responsible for hepatobiliary disposition of micafungin in human and rat.	Micafungin	110-120	ATP binding cassette subfamily B member 11	Homo sapiens	41-45
20606004-9	2010	These results suggest that NTCP/Ntcp and BSEP/Bsep are primarily responsible for hepatobiliary disposition of micafungin in human and rat.	Micafungin	110-120	ATP binding cassette subfamily B member 11	Homo sapiens	46-50
20307632-3	2010	TGZS inhibits bile salt export pump (BSEP) that causes accumulation of bile salts in liver.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	14-35
20028269-0	2010	Role of the bile salt export pump, BSEP, in acquired forms of cholestasis.	Bile Acids and Salts	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	35-39
20028269-3	2010	The bile salt export pump, BSEP, is critically involved in the secretion of bile salts into bile.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
20028269-3	2010	The bile salt export pump, BSEP, is critically involved in the secretion of bile salts into bile.	Bile Acids and Salts	76-86	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
20028269-6	2010	In addition to mutations, BSEP can be inhibited by acquired factors, such as xenobiotics or drugs, aberrant bile salt metabolites, or pregnancy.	Bile Acids and Salts	108-117	ATP binding cassette subfamily B member 11	Homo sapiens	26-30
20447715-1	2010	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis (PFIC) with normal serum levels of gamma-glutamyltranspeptidase can result from mutations in ATP8B1 (encoding familial intrahepatic cholestasis 1 [FIC1]) or ABCB11 (encoding bile salt export pump [BSEP]).	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	226-232
20447715-1	2010	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis (PFIC) with normal serum levels of gamma-glutamyltranspeptidase can result from mutations in ATP8B1 (encoding familial intrahepatic cholestasis 1 [FIC1]) or ABCB11 (encoding bile salt export pump [BSEP]).	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	243-264
20447715-1	2010	BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis (PFIC) with normal serum levels of gamma-glutamyltranspeptidase can result from mutations in ATP8B1 (encoding familial intrahepatic cholestasis 1 [FIC1]) or ABCB11 (encoding bile salt export pump [BSEP]).	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	266-270
20447715-6	2010	RESULTS: At presentation, serum aminotransferase and bile salt levels were higher in BSEP patients; serum alkaline phosphatase values were higher, and serum albumin values were lower, in FIC1 patients.	Bile Acids and Salts	53-62	ATP binding cassette subfamily B member 11	Homo sapiens	85-89
20307632-3	2010	TGZS inhibits bile salt export pump (BSEP) that causes accumulation of bile salts in liver.	Bile Acids and Salts	71-81	ATP binding cassette subfamily B member 11	Homo sapiens	37-41
19653193-6	2010	Consistently, OA partially blocked the ability of CDCA to induce a FXR target gene bile salt export protein (BSEP).	Chenodeoxycholic Acid	50-54	ATP binding cassette subfamily B member 11	Homo sapiens	109-113
20219403-0	2010	Favorable effect of 4-phenylacetate on liver functions attributable to enhanced bile salt export pump expression in ornithine transcarbamylase-deficient children.	4-phenylacetate	20-35	ATP binding cassette subfamily B member 11	Homo sapiens	80-101
20219403-2	2010	Results of our recent experiments using animals and cultured cells strongly suggest that this agent enhances the function of bile salt export pump/ATP binding cassette B11 (BSEP/ABCB11) promoting bile acid excretion from hepatocytes to bile canaliculi, although it has not been confirmed in humans.	Bile Acids and Salts	196-205	ATP binding cassette subfamily B member 11	Homo sapiens	125-146
20219403-2	2010	Results of our recent experiments using animals and cultured cells strongly suggest that this agent enhances the function of bile salt export pump/ATP binding cassette B11 (BSEP/ABCB11) promoting bile acid excretion from hepatocytes to bile canaliculi, although it has not been confirmed in humans.	Bile Acids and Salts	196-205	ATP binding cassette subfamily B member 11	Homo sapiens	173-177
20219403-2	2010	Results of our recent experiments using animals and cultured cells strongly suggest that this agent enhances the function of bile salt export pump/ATP binding cassette B11 (BSEP/ABCB11) promoting bile acid excretion from hepatocytes to bile canaliculi, although it has not been confirmed in humans.	Bile Acids and Salts	196-205	ATP binding cassette subfamily B member 11	Homo sapiens	178-184
20219403-9	2010	Western blot analyzes of the liver samples revealed that the 4-PA administration enhanced BSEP/ABCB11 protein expressions in the membranous fraction of liver cells, although the liver BSEP/ABCB11 messenger RNA level remained unchanged.	4-pa	61-65	ATP binding cassette subfamily B member 11	Homo sapiens	90-94
20219403-9	2010	Western blot analyzes of the liver samples revealed that the 4-PA administration enhanced BSEP/ABCB11 protein expressions in the membranous fraction of liver cells, although the liver BSEP/ABCB11 messenger RNA level remained unchanged.	4-pa	61-65	ATP binding cassette subfamily B member 11	Homo sapiens	95-101
20219403-10	2010	These results suggest that 4-PA enhanced liver BSEP/ABCB11 function and thereby improved liver functions in OTC-deficient children.	4-pa	27-31	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
20219403-10	2010	These results suggest that 4-PA enhanced liver BSEP/ABCB11 function and thereby improved liver functions in OTC-deficient children.	4-pa	27-31	ATP binding cassette subfamily B member 11	Homo sapiens	52-58
20219403-11	2010	For treatment of liver disorders requiring enhancement of BSEP function, 4-PA might be a candidate.	4-pa	73-77	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
20422494-10	2010	Although the exact etiology of cholestasis is incompletely understood, it is hypothesized that ATP8B1 deficiency results in enhanced cholesterol extraction from the canalicular membrane, which impairs the function of the bile salt export pump (BSEP), resulting in cholestasis.	Cholesterol	133-144	ATP binding cassette subfamily B member 11	Homo sapiens	221-242
20422494-10	2010	Although the exact etiology of cholestasis is incompletely understood, it is hypothesized that ATP8B1 deficiency results in enhanced cholesterol extraction from the canalicular membrane, which impairs the function of the bile salt export pump (BSEP), resulting in cholestasis.	Cholesterol	133-144	ATP binding cassette subfamily B member 11	Homo sapiens	244-248
20422495-1	2010	The primary transporter responsible for bile salt secretion is the bile salt export pump (BSEP, ABCB11), a member of the ATP-binding cassette (ABC) superfamily, which is located at the bile canalicular apical domain of hepatocytes.	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	67-88
20422495-1	2010	The primary transporter responsible for bile salt secretion is the bile salt export pump (BSEP, ABCB11), a member of the ATP-binding cassette (ABC) superfamily, which is located at the bile canalicular apical domain of hepatocytes.	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	90-94
20422495-1	2010	The primary transporter responsible for bile salt secretion is the bile salt export pump (BSEP, ABCB11), a member of the ATP-binding cassette (ABC) superfamily, which is located at the bile canalicular apical domain of hepatocytes.	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	96-102
20422495-3	2010	Because bile salts play a pivotal role in a wide range of physiologic and pathophysiologic processes, regulation of BSEP expression has been a subject of intense research.	Bile Acids and Salts	8-18	ATP binding cassette subfamily B member 11	Homo sapiens	116-120
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	121-125
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	233-237
20422497-5	2010	In addition, genetic variants (as well as mutants) of the genes coding for the phosphatidylcholine translocator MDR3 and BSEP and for the farnesoid X receptor, which is critical in the transcriptional activation of MDR3 ( ABCB4) and BSEP ( ABCB11) have been associated with intrahepatic cholestasis of pregnancy.	Phosphatidylcholines	79-98	ATP binding cassette subfamily B member 11	Homo sapiens	240-246
20628435-8	2010	Only sitaxsentan decreased OATP transport (52%), and only bosentan reduced BSEP transport (78%).	Bosentan	58-66	ATP binding cassette subfamily B member 11	Homo sapiens	75-79
20628435-13	2010	Only bosentan and darusentan were shown as substrates for both BSEP and P-glycoprotein efflux.	Bosentan	5-13	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
20628435-13	2010	Only bosentan and darusentan were shown as substrates for both BSEP and P-glycoprotein efflux.	darusentan	18-28	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
20147439-7	2010	The inhibition of BSEP/Bsep resulted in significantly higher intracellular TC(conc) in humans than in rats.	Taurocholic Acid	75-77	ATP binding cassette subfamily B member 11	Homo sapiens	18-22
20147439-7	2010	The inhibition of BSEP/Bsep resulted in significantly higher intracellular TC(conc) in humans than in rats.	Taurocholic Acid	75-77	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	11-21	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	11-21	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Taurine	31-38	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Taurine	31-38	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Glycine	44-51	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Glycine	44-51	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	63-73	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	63-73	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	101-110	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
20460875-1	2010	Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11).	Bile Acids and Salts	101-110	ATP binding cassette subfamily B member 11	Homo sapiens	131-137
20460875-4	2010	The role and function of hBSEP have been investigated by the examination of the ATP-dependent transport of radioactive isotopically (RI)-labeled bile acid such as a tritium labeled taurocholic acid, in membrane vesicles obtained from hBSEP-expressing cells.	Adenosine Triphosphate	80-83	ATP binding cassette subfamily B member 11	Homo sapiens	25-30
20460875-4	2010	The role and function of hBSEP have been investigated by the examination of the ATP-dependent transport of radioactive isotopically (RI)-labeled bile acid such as a tritium labeled taurocholic acid, in membrane vesicles obtained from hBSEP-expressing cells.	Bile Acids and Salts	145-154	ATP binding cassette subfamily B member 11	Homo sapiens	25-30
20460875-4	2010	The role and function of hBSEP have been investigated by the examination of the ATP-dependent transport of radioactive isotopically (RI)-labeled bile acid such as a tritium labeled taurocholic acid, in membrane vesicles obtained from hBSEP-expressing cells.	Tritium	165-172	ATP binding cassette subfamily B member 11	Homo sapiens	25-30
20460875-4	2010	The role and function of hBSEP have been investigated by the examination of the ATP-dependent transport of radioactive isotopically (RI)-labeled bile acid such as a tritium labeled taurocholic acid, in membrane vesicles obtained from hBSEP-expressing cells.	Taurocholic Acid	181-197	ATP binding cassette subfamily B member 11	Homo sapiens	25-30
20460875-6	2010	This method is extremely sensitive and it may be applicable for the measurements of bile acid transport activities by hBSEP vesicles without using RI-labeled bile acid.	Bile Acids and Salts	84-93	ATP binding cassette subfamily B member 11	Homo sapiens	118-123
20460875-7	2010	The present paper deals with an application of the chemiluminescence detection method using 3alpha-HSD with enzyme cycling method to the measurement of ATP-dependent transport activities of taurocholic acid (T-CA) in membrane vesicles obtained from hBSEP-expressing Sf9 cells.	Adenosine Triphosphate	152-155	ATP binding cassette subfamily B member 11	Homo sapiens	249-254
20460875-7	2010	The present paper deals with an application of the chemiluminescence detection method using 3alpha-HSD with enzyme cycling method to the measurement of ATP-dependent transport activities of taurocholic acid (T-CA) in membrane vesicles obtained from hBSEP-expressing Sf9 cells.	Taurocholic Acid	190-206	ATP binding cassette subfamily B member 11	Homo sapiens	249-254
19653193-6	2010	Consistently, OA partially blocked the ability of CDCA to induce a FXR target gene bile salt export protein (BSEP).	Bile Acids and Salts	83-92	ATP binding cassette subfamily B member 11	Homo sapiens	109-113
19706322-4	2010	[(3)H]-Taurocholate served as the NTCP/BSEP probe substrate.	[(3)h]-taurocholate	0-19	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
19937311-0	2010	Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.	Glucose	91-98	ATP binding cassette subfamily B member 11	Homo sapiens	40-46
19821532-1	2009	UNLABELLED: The bile salt export pump (BSEP) is the major determinant of bile salt-dependent bile secretion, and its deficiency leads to cholestatic liver injury.	Bile Acids and Salts	16-25	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
20460828-1	2010	A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11).	Bile Acids and Salts	20-29	ATP binding cassette subfamily B member 11	Homo sapiens	224-228
20460828-1	2010	A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11).	4-n,n-dimethylaminosulfonyl-2,1,3-benzoxadiazole	42-90	ATP binding cassette subfamily B member 11	Homo sapiens	224-228
20460828-1	2010	A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11).	Bile Acids and Salts	103-112	ATP binding cassette subfamily B member 11	Homo sapiens	224-228
20460828-1	2010	A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11).	Bile Acids and Salts	201-210	ATP binding cassette subfamily B member 11	Homo sapiens	224-228
20460828-2	2010	The transport properties of the synthetic fluorescent bile acid derivative in membrane vesicles obtained from hBSEP-expressing Sf9 cells were examined using the liquid chromatography-electrospray ionization-mass spectrometry method.	Bile Acids and Salts	54-63	ATP binding cassette subfamily B member 11	Homo sapiens	110-115
20460828-3	2010	The Michaelis-Menten constant and maximum uptake rate for the synthetic fluorescent bile acid derivative by hBSEP were 23.1+/-1.6 microM and 623.2+/-22.4 pmol/min/mg protein, respectively.	Bile Acids and Salts	84-93	ATP binding cassette subfamily B member 11	Homo sapiens	108-113
20460828-5	2010	Moreover, we examined inhibitory effects of various drugs on hBSEP-mediated uptake of the fluorescent bile acid derivative using a fluorescence detection method.	Bile Acids and Salts	102-111	ATP binding cassette subfamily B member 11	Homo sapiens	61-66
20460828-7	2010	Our results suggest that the synthetic fluorescent bile acid derivative may be useful for evaluation of the inhibitory effects of various drugs on hBSEP-mediated uptake.	Bile Acids and Salts	51-60	ATP binding cassette subfamily B member 11	Homo sapiens	147-152
19821532-7	2009	Oltipraz, a potent activator of Nrf2, increased BSEP messenger RNA expression by approximately seven-fold in HepG2 cells and protein by approximately 70% in human hepatocytes.	oltipraz	0-8	ATP binding cassette subfamily B member 11	Homo sapiens	48-52
19821532-8	2009	Small interfering RNAs lowered NRF2 expression in HepG2 cells and prevented the up-regulation of BSEP by oltipraz.	oltipraz	105-113	ATP binding cassette subfamily B member 11	Homo sapiens	97-101
19369578-5	2009	More specifically, troglitazone acted as a partial agonist of FXR to weakly increase BSEP and SHP expression but functioned as a potent antagonist to significantly suppress bile acid-induced expression.	Troglitazone	19-31	ATP binding cassette subfamily B member 11	Homo sapiens	85-89
20142127-9	2009	The data examined include all cases on the ACGME SOL submitted by each PGY-4 and 5 residents over a 2-year span.	acgme	43-48	ATP binding cassette subfamily B member 11	Homo sapiens	71-76
19669124-0	2009	A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.	Glucose	113-120	ATP binding cassette subfamily B member 11	Homo sapiens	23-29
19669124-0	2009	A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.	Glucose	113-120	ATP binding cassette subfamily B member 11	Homo sapiens	23-29
19669124-1	2009	AIMS/HYPOTHESIS: An association between elevated fasting plasma glucose and the common rs560887 G allele in the G6PC2/ABCB11 locus has been reported.	Glucose	64-71	ATP binding cassette subfamily B member 11	Homo sapiens	118-124
19669124-11	2009	CONCLUSIONS/INTERPRETATION: The common rs560887 G allele in the G6PC2/ABCB11 locus is associated with increased fasting glycaemia and increased risk of IFG, associations that may be partly related to an increased basal hepatic glucose production rate.	Glucose	227-234	ATP binding cassette subfamily B member 11	Homo sapiens	70-76
19642168-1	2009	Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP-binding cassette (ABC)-transporter exclusively expressed at the canalicular membrane of hepatocytes.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	54-60
19642168-1	2009	Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP-binding cassette (ABC)-transporter exclusively expressed at the canalicular membrane of hepatocytes.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	115-119
19642168-1	2009	Progressive familial intrahepatic cholestasis type 2 (PFIC-2) is caused by mutations of the bile salt export pump (BSEP [ABCB11]), an ATP-binding cassette (ABC)-transporter exclusively expressed at the canalicular membrane of hepatocytes.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	121-127
19369578-4	2009	In this study, we demonstrated that troglitazone but not rosiglitazone or pioglitazone modulated expression of farnesoid X receptor (FXR) target genes bile salt export pump (BSEP) and small heterodimer partner (SHP) in Huh-7 cells.	Troglitazone	36-48	ATP binding cassette subfamily B member 11	Homo sapiens	151-172
19369578-4	2009	In this study, we demonstrated that troglitazone but not rosiglitazone or pioglitazone modulated expression of farnesoid X receptor (FXR) target genes bile salt export pump (BSEP) and small heterodimer partner (SHP) in Huh-7 cells.	Troglitazone	36-48	ATP binding cassette subfamily B member 11	Homo sapiens	174-178
19669124-0	2009	A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.	Glucose	80-87	ATP binding cassette subfamily B member 11	Homo sapiens	23-29
19369578-6	2009	Consistent with the finding, troglitazone partially induced but markedly antagonized bile acid-mediated BSEP promoter transactivation.	Troglitazone	29-41	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
19369578-6	2009	Consistent with the finding, troglitazone partially induced but markedly antagonized bile acid-mediated BSEP promoter transactivation.	Bile Acids and Salts	85-94	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
19408031-2	2009	Our objective was to analyze the relationship between plasma lipid levels and common polymorphisms of ABCB11 (encoding the bile salt export pump, BSEP) and ABCB4 (encoding the phospholipid transporter into bile, MDR3) genes.	Bile Acids and Salts	123-132	ATP binding cassette subfamily B member 11	Homo sapiens	102-108
19684528-3	2009	Bile salts are an important constituent of bile and are secreted by the bile salt export pump (BSEP) from hepatocytes.	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	72-93
19684528-3	2009	Bile salts are an important constituent of bile and are secreted by the bile salt export pump (BSEP) from hepatocytes.	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	95-99
19684528-8	2009	Because BSEP is the rate-limiting step in hepatocellular bile salt transport, it controls the spill over of bile salts into the systemic circulation.	Bile Acids and Salts	57-66	ATP binding cassette subfamily B member 11	Homo sapiens	8-12
19684528-8	2009	Because BSEP is the rate-limiting step in hepatocellular bile salt transport, it controls the spill over of bile salts into the systemic circulation.	Bile Acids and Salts	108-118	ATP binding cassette subfamily B member 11	Homo sapiens	8-12
19408031-7	2009	Among cases, triglyceride and cholesterol levels were higher in carriers of the common versus rare (hetero/homozygous carriers) allele of the SNPs p.A444V of ABCB11 and C.504C > T of ABCB4.	Triglycerides	13-25	ATP binding cassette subfamily B member 11	Homo sapiens	158-164
19408031-7	2009	Among cases, triglyceride and cholesterol levels were higher in carriers of the common versus rare (hetero/homozygous carriers) allele of the SNPs p.A444V of ABCB11 and C.504C > T of ABCB4.	Cholesterol	30-41	ATP binding cassette subfamily B member 11	Homo sapiens	158-164
18798335-1	2008	The bile salt export pump (Bsep) represents the major bile salt transport system at the canalicular membrane of hepatocytes.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
19571440-1	2009	The bile salt export pump (BSEP) encoded by ABCB11 is located in the canalicular membrane of hepatocytes and mediates the secretion of numerous conjugated bile salts into the bile canaliculus.	Bile Acids and Salts	155-165	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
19571440-1	2009	The bile salt export pump (BSEP) encoded by ABCB11 is located in the canalicular membrane of hepatocytes and mediates the secretion of numerous conjugated bile salts into the bile canaliculus.	Bile Acids and Salts	155-165	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
19571440-1	2009	The bile salt export pump (BSEP) encoded by ABCB11 is located in the canalicular membrane of hepatocytes and mediates the secretion of numerous conjugated bile salts into the bile canaliculus.	Bile Acids and Salts	155-165	ATP binding cassette subfamily B member 11	Homo sapiens	44-50
19029016-6	2009	A good rank order correlation was found between IC(50) values measured in TCDC-stimulated mBsep ATPase assay and in the human BSEP vesicular transport assay utilizing taurocholate (TC) as probe substrate.	Taurocholic Acid	167-179	ATP binding cassette subfamily B member 11	Homo sapiens	126-130
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Rhodamine 123	139-152	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	calcein AM	154-164	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19111018-4	2009	Therefore, we evaluated the role of vitamin A/9cRA in the expression of human and mouse bile salt export pump (hBSEP/mBsep), small heterodimer partner (hSHP/mShp), and mouse sodium-dependent taurocholate co-transporting polypeptide (mNtcp).	Vitamin A	36-45	ATP binding cassette subfamily B member 11	Homo sapiens	111-116
19111018-4	2009	Therefore, we evaluated the role of vitamin A/9cRA in the expression of human and mouse bile salt export pump (hBSEP/mBsep), small heterodimer partner (hSHP/mShp), and mouse sodium-dependent taurocholate co-transporting polypeptide (mNtcp).	Alitretinoin	46-50	ATP binding cassette subfamily B member 11	Homo sapiens	111-116
19111018-8	2009	Results indicated that 9cRA strongly repressed the CDCA-induced BSEP transcription in HepG2 cells, whereas it super-induced SHP transcription; 9cRA reduced DNA-binding of FXR and RXRalpha.	Chenodeoxycholic Acid	51-55	ATP binding cassette subfamily B member 11	Homo sapiens	64-68
19029016-1	2009	The mouse ortholog of the human bile salt export pump (BSEP) transporter was expressed in a baculovirus-infected insect cell (Sf9) system to study the effect of membrane cholesterol content on the transporter function.	Cholesterol	170-181	ATP binding cassette subfamily B member 11	Homo sapiens	32-53
19029016-1	2009	The mouse ortholog of the human bile salt export pump (BSEP) transporter was expressed in a baculovirus-infected insect cell (Sf9) system to study the effect of membrane cholesterol content on the transporter function.	Cholesterol	170-181	ATP binding cassette subfamily B member 11	Homo sapiens	55-59
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Bodipy-verapamil	166-182	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	dihydrofluorescein diacetat	187-214	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Verapamil	173-182	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Cyclosporine	246-260	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	verlukast	262-267	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	reversine 205	269-282	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Taurocholic Acid	284-296	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
19008001-6	2008	In addition, the presence of Pgp1-, BSEP- and MRP-like transport activities were indicated using putative specific fluorescent substrates (rhodamine 123, calcein-AM, bodipy-verapamil and dihydrofluorescein diacetat), model inhibitors (verapamil, cyclosporine A, MK571, reversine 205, taurocholate and taurochenodeoxycholate) and their combinations.	Taurochenodeoxycholic Acid	301-323	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
18985798-5	2008	The uptake of [(3)H]taurocholic acid by all three transporters was significantly inhibited by troglitazone, glibenclamide, and other several inhibitors, while pravastatin inhibited dog Bsep and human BSEP, but not rat Bsep at 100 microM.	[(3)h]taurocholic acid	14-36	ATP binding cassette subfamily B member 11	Homo sapiens	200-204
18985798-5	2008	The uptake of [(3)H]taurocholic acid by all three transporters was significantly inhibited by troglitazone, glibenclamide, and other several inhibitors, while pravastatin inhibited dog Bsep and human BSEP, but not rat Bsep at 100 microM.	Troglitazone	94-106	ATP binding cassette subfamily B member 11	Homo sapiens	200-204
18985798-5	2008	The uptake of [(3)H]taurocholic acid by all three transporters was significantly inhibited by troglitazone, glibenclamide, and other several inhibitors, while pravastatin inhibited dog Bsep and human BSEP, but not rat Bsep at 100 microM.	Glyburide	108-121	ATP binding cassette subfamily B member 11	Homo sapiens	200-204
18985798-5	2008	The uptake of [(3)H]taurocholic acid by all three transporters was significantly inhibited by troglitazone, glibenclamide, and other several inhibitors, while pravastatin inhibited dog Bsep and human BSEP, but not rat Bsep at 100 microM.	Pravastatin	159-170	ATP binding cassette subfamily B member 11	Homo sapiens	200-204
18985798-6	2008	The IC(50) of troglitazone for dog Bsep, human BSEP, and rat Bsep were 32, 20, and 60 microM, and those of pravastatin were 441, 240 and >1,000 microM, respectively.	Troglitazone	14-26	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
18521185-0	2008	Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.	Glucose	74-81	ATP binding cassette subfamily B member 11	Homo sapiens	24-30
18270374-1	2008	The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids.	Cholesterol	28-39	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
18668439-2	2008	Sodium (Na(+))-dependent bile acid uptake from portal blood into the liver is mediated primarily by the Na(+) taurocholate co-transporting polypeptide (NTCP), while secretion across the canalicular membrane into the bile is carried out by the bile salt export pump (BSEP).	Sodium	0-6	ATP binding cassette subfamily B member 11	Homo sapiens	243-264
18668439-2	2008	Sodium (Na(+))-dependent bile acid uptake from portal blood into the liver is mediated primarily by the Na(+) taurocholate co-transporting polypeptide (NTCP), while secretion across the canalicular membrane into the bile is carried out by the bile salt export pump (BSEP).	Sodium	0-6	ATP binding cassette subfamily B member 11	Homo sapiens	266-270
18668439-2	2008	Sodium (Na(+))-dependent bile acid uptake from portal blood into the liver is mediated primarily by the Na(+) taurocholate co-transporting polypeptide (NTCP), while secretion across the canalicular membrane into the bile is carried out by the bile salt export pump (BSEP).	Bile Acids and Salts	25-34	ATP binding cassette subfamily B member 11	Homo sapiens	243-264
18668439-2	2008	Sodium (Na(+))-dependent bile acid uptake from portal blood into the liver is mediated primarily by the Na(+) taurocholate co-transporting polypeptide (NTCP), while secretion across the canalicular membrane into the bile is carried out by the bile salt export pump (BSEP).	Bile Acids and Salts	25-34	ATP binding cassette subfamily B member 11	Homo sapiens	266-270
18770956-4	2008	Both BRIC types originate from impaired function bile salt excretion from hepatocytes to the canaliculi which is mediated by the bile salt export pump (BSEP) which is located on the hepatyocyte membrane, unevenly distributed within the membrane lipid bilayer.	Bile Acids and Salts	49-58	ATP binding cassette subfamily B member 11	Homo sapiens	129-150
18770956-4	2008	Both BRIC types originate from impaired function bile salt excretion from hepatocytes to the canaliculi which is mediated by the bile salt export pump (BSEP) which is located on the hepatyocyte membrane, unevenly distributed within the membrane lipid bilayer.	Bile Acids and Salts	49-58	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
18770956-4	2008	Both BRIC types originate from impaired function bile salt excretion from hepatocytes to the canaliculi which is mediated by the bile salt export pump (BSEP) which is located on the hepatyocyte membrane, unevenly distributed within the membrane lipid bilayer.	Lipid Bilayers	245-258	ATP binding cassette subfamily B member 11	Homo sapiens	129-150
18770956-4	2008	Both BRIC types originate from impaired function bile salt excretion from hepatocytes to the canaliculi which is mediated by the bile salt export pump (BSEP) which is located on the hepatyocyte membrane, unevenly distributed within the membrane lipid bilayer.	Lipid Bilayers	245-258	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
18270374-1	2008	The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids.	Bile Acids and Salts	45-55	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
18270374-1	2008	The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids.	Cholesterol	99-110	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
18270374-1	2008	The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids.	Bile Acids and Salts	230-240	ATP binding cassette subfamily B member 11	Homo sapiens	153-174
18270374-1	2008	The metabolic conversion of cholesterol into bile acids in liver is initiated by the rate-limiting cholesterol 7 alpha-hydroxylase (CYP7A1), whereas the bile salt export pump (BSEP) is responsible for the canalicular secretion of bile acids.	Bile Acids and Salts	230-240	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
18270374-6	2008	In addition, such transactivation by LRH-1 was required for maximal induction of BSEP expression through the bile acid/farnesoid X receptor (FXR) activation pathway.	Bile Acids and Salts	109-118	ATP binding cassette subfamily B member 11	Homo sapiens	81-85
18270374-9	2008	In conclusion, LRH-1 transcriptionally activated the BSEP promoter and functioned as a modulator in bile acid/FXR-mediated BSEP regulation.	Bile Acids and Salts	100-109	ATP binding cassette subfamily B member 11	Homo sapiens	123-127
18270374-10	2008	These results suggest that LRH-1 plays a supporting role to FXR in maintaining hepatic bile acid levels by coordinately regulating CYP7A1 and BSEP for bile acid synthesis and elimination, respectively.	Bile Acids and Salts	151-160	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
17409513-3	2007	We examined the inhibitory effects of flutamide and its active metabolite, hydroxyflutamide, on the transport of taurocholic acid (TCA) by membrane vesicles derived from hBSEP-expressing Sf9 cells.	Flutamide	38-47	ATP binding cassette subfamily B member 11	Homo sapiens	170-175
17855769-7	2007	All Bsep mutants accumulate in perinuclear aggresome-like structures in the presence of the proteasome inhibitor MG-132, suggesting that mutations are associated with protein instability and ubiquitin-dependent degradation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	113-119	ATP binding cassette subfamily B member 11	Homo sapiens	4-8
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	STIGMASTEROL ACETATE	16-36	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	STIGMASTEROL ACETATE	38-44	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
17622954-3	2007	In HepG2 cells, stigmasterol acetate (StigAc), a water-soluble Stig derivative, suppressed ligand-activated expression of FXR target genes involved in adaptation to cholestasis (i.e. BSEP, FGF-19, OSTalpha/beta).	stig	38-42	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
17538928-4	2007	Because sodium 4-phenylbutyrate (4PBA) has been shown to restore the reduced cell surface expression of mutated plasma membrane proteins, in the current study, we investigated the effect of 4PBA treatment on E297G and D482G BSEP.	4-phenylbutyric acid	190-194	ATP binding cassette subfamily B member 11	Homo sapiens	224-228
17538928-5	2007	Transcellular transport and cell surface biotinylation studies using Madin-Darby canine kidney (MDCK) II cells demonstrated that 4PBA treatment increased functional cell surface expression of wild-type (WT), E297G, and D482G BSEP.	4-phenylbutyric acid	129-133	ATP binding cassette subfamily B member 11	Homo sapiens	225-229
17452236-2	2007	BSEP deficiency may cause cholangiocarcinoma through bile-composition shifts or bile-acid damage within cells capable of hepatocytic/cholangiocytic differentiation.	Bile Acids and Salts	80-89	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
18395098-1	2008	BACKGROUND & AIMS: Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic liver disease.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	44-65
18395098-1	2008	BACKGROUND & AIMS: Patients with severe bile salt export pump (BSEP) deficiency present as infants with progressive cholestatic liver disease.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
18176959-10	2008	Serum bile acid and gamma-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC.	Bile Acids and Salts	6-15	ATP binding cassette subfamily B member 11	Homo sapiens	91-97
18188816-6	2008	In addition, we detected the ABCB11 polymorphism V 444A, which is associated with a decreased expression of the bile salt export pump.	Bile Acids and Salts	112-121	ATP binding cassette subfamily B member 11	Homo sapiens	29-35
18049162-0	2007	Gradual improvement of liver function after administration of ursodeoxycholic acid in an infant with a novel ABCB11 gene mutation with phenotypic continuum between BRIC2 and PFIC2.	Ursodeoxycholic Acid	62-82	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
18049162-0	2007	Gradual improvement of liver function after administration of ursodeoxycholic acid in an infant with a novel ABCB11 gene mutation with phenotypic continuum between BRIC2 and PFIC2.	Ursodeoxycholic Acid	62-82	ATP binding cassette subfamily B member 11	Homo sapiens	164-169
18049162-0	2007	Gradual improvement of liver function after administration of ursodeoxycholic acid in an infant with a novel ABCB11 gene mutation with phenotypic continuum between BRIC2 and PFIC2.	Ursodeoxycholic Acid	62-82	ATP binding cassette subfamily B member 11	Homo sapiens	174-179
17404808-5	2007	After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs).	Bile Acids and Salts	29-38	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
17404808-5	2007	After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs).	Bile Acids and Salts	56-66	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
17404808-5	2007	After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs).	Adenosine Triphosphate	105-108	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
17404808-5	2007	After binding to a cytosolic bile acid binding protein, bile acids are secreted into the canaliculus via ATP-dependent bile salt excretory pump (BSEP) and multi drug resistant proteins (MRPs).	Bile Acids and Salts	119-128	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
17538928-9	2007	4PBA is a potential pharmacological agent for treating not only PFIC2 patients with E297G and D482G mutations but also other cholestatic patients, in whom the BSEP expression at the canalicular membrane is reduced.	4-phenylbutyric acid	0-4	ATP binding cassette subfamily B member 11	Homo sapiens	64-69
17538928-9	2007	4PBA is a potential pharmacological agent for treating not only PFIC2 patients with E297G and D482G mutations but also other cholestatic patients, in whom the BSEP expression at the canalicular membrane is reduced.	4-phenylbutyric acid	0-4	ATP binding cassette subfamily B member 11	Homo sapiens	159-163
17409513-3	2007	We examined the inhibitory effects of flutamide and its active metabolite, hydroxyflutamide, on the transport of taurocholic acid (TCA) by membrane vesicles derived from hBSEP-expressing Sf9 cells.	hydroxyflutamide	75-91	ATP binding cassette subfamily B member 11	Homo sapiens	170-175
17409513-3	2007	We examined the inhibitory effects of flutamide and its active metabolite, hydroxyflutamide, on the transport of taurocholic acid (TCA) by membrane vesicles derived from hBSEP-expressing Sf9 cells.	Taurocholic Acid	113-129	ATP binding cassette subfamily B member 11	Homo sapiens	170-175
17409513-3	2007	We examined the inhibitory effects of flutamide and its active metabolite, hydroxyflutamide, on the transport of taurocholic acid (TCA) by membrane vesicles derived from hBSEP-expressing Sf9 cells.	Taurocholic Acid	131-134	ATP binding cassette subfamily B member 11	Homo sapiens	170-175
17190787-1	2007	By comparing ovarian carcinoma-derived KF28 cells with the corresponding anticancer drug-resistant cells, the taxol- and cisplatin-resistant properties were found to be closely related with MDR1 and BSEP, and MRP2 transporters, respectively.	Paclitaxel	110-115	ATP binding cassette subfamily B member 11	Homo sapiens	199-203
17291602-4	2007	The genes encoding for organic anion uptake (NTCP, OATPs), canalicular export (BSEP, MRP2) and alternative basolateral export (MRP3, MRP4) in liver are regulated by a complex interacting network of hepatocyte nuclear factors (HNF1, 3, 4) and nuclear (orphan) receptors (e.g., FXR, PXR, CAR, RAR, LRH-1, SHP, GR).	periodate-oxidized adenosine 5'-triphosphate	51-56	ATP binding cassette subfamily B member 11	Homo sapiens	79-83
17190787-1	2007	By comparing ovarian carcinoma-derived KF28 cells with the corresponding anticancer drug-resistant cells, the taxol- and cisplatin-resistant properties were found to be closely related with MDR1 and BSEP, and MRP2 transporters, respectively.	Cisplatin	121-130	ATP binding cassette subfamily B member 11	Homo sapiens	199-203
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Cholesterol	14-25	ATP binding cassette subfamily B member 11	Homo sapiens	196-217
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Cholesterol	14-25	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
17135343-0	2007	The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonism.	pregna-4,17-diene-3,16-dione	24-37	ATP binding cassette subfamily B member 11	Homo sapiens	72-93
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Bile Acids and Salts	29-39	ATP binding cassette subfamily B member 11	Homo sapiens	196-217
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Bile Acids and Salts	29-39	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Bile Acids and Salts	151-161	ATP binding cassette subfamily B member 11	Homo sapiens	196-217
17135343-1	2007	Conversion of cholesterol to bile acids in the liver is initiated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1) and excretion of bile acids from the liver is mediated by the bile salt export pump (BSEP).	Bile Acids and Salts	151-161	ATP binding cassette subfamily B member 11	Homo sapiens	219-223
17135343-2	2007	The expression of CYP7A1 and BSEP is coordinately regulated by a negative feedback and positive feed-forward mechanism, respectively, through bile acid-mediated activation of farsenoid X receptor (FXR).	Bile Acids and Salts	142-151	ATP binding cassette subfamily B member 11	Homo sapiens	29-33
17135343-4	2007	In this study, however, we have demonstrated that guggulsterone synergistically induced the expression of BSEP in cells treated with FXR agonist bile acids.	pregna-4,17-diene-3,16-dione	50-63	ATP binding cassette subfamily B member 11	Homo sapiens	106-110
17135343-4	2007	In this study, however, we have demonstrated that guggulsterone synergistically induced the expression of BSEP in cells treated with FXR agonist bile acids.	Bile Acids and Salts	145-155	ATP binding cassette subfamily B member 11	Homo sapiens	106-110
17135343-5	2007	A dissection study located in the BSEP promoter an activating protein (AP)-1 site supporting the action of guggulsterone.	pregna-4,17-diene-3,16-dione	107-120	ATP binding cassette subfamily B member 11	Homo sapiens	34-38
17135343-7	2007	Selective c-Jun N-terminal kinase and extracellular signal-regulated kinase inhibitors markedly decreased the transactivation, suggesting an involvement of AP-1 activation pathway in the up-regulation of BSEP by guggulsterone.	pregna-4,17-diene-3,16-dione	212-225	ATP binding cassette subfamily B member 11	Homo sapiens	204-208
17135343-8	2007	Consistent with its FXR antagonism, guggulsterone antagonized bile acid-mediated transactivation of BSEP promoter when the AP-1 element was disrupted.	pregna-4,17-diene-3,16-dione	36-49	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
17135343-8	2007	Consistent with its FXR antagonism, guggulsterone antagonized bile acid-mediated transactivation of BSEP promoter when the AP-1 element was disrupted.	Bile Acids and Salts	62-71	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
17135343-9	2007	In conclusion, guggulsterone regulates BSEP expression through composite mechanisms, and the transactivation through the AP-1 element is dominant over the FXR-mediated antagonism.	pregna-4,17-diene-3,16-dione	15-28	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
17135343-10	2007	The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated hypolipidemic effect.	pregna-4,17-diene-3,16-dione	40-53	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
17135343-10	2007	The up-regulation of BSEP expression by guggulsterone without activating FXR pathway as an FXR agonist to suppress CYP7A1 expression represents a possible mechanism for guggulsterone-mediated hypolipidemic effect.	pregna-4,17-diene-3,16-dione	169-182	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
17181454-2	2007	Human ATP-binding cassette transporter ABCB11 (sister of P-glycoprotein/bile salt export pump) mediates the elimination of cytotoxic bile salts from liver cells to bile, and, therefore, plays a critical role in the generation of bile flow.	Bile Acids and Salts	133-143	ATP binding cassette subfamily B member 11	Homo sapiens	39-45
17051391-1	2007	Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.	Bile Acids and Salts	25-35	ATP binding cassette subfamily B member 11	Homo sapiens	52-73
17051391-1	2007	Canalicular secretion of bile salts mediated by the bile salt export pump Bsep constitutes the major driving force for the generation of bile flow.	Bile Acids and Salts	25-35	ATP binding cassette subfamily B member 11	Homo sapiens	74-78
17051391-3	2007	Bsep has a narrow substrate specificity, which is largely restricted to bile salts.	Bile Acids and Salts	72-82	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
17297425-8	2007	The bile salt export pump (BSEP) mediates uphill canalicular bile acid secretion.	Bile Acids and Salts	61-70	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
17297425-8	2007	The bile salt export pump (BSEP) mediates uphill canalicular bile acid secretion.	Bile Acids and Salts	61-70	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
17181454-2	2007	Human ATP-binding cassette transporter ABCB11 (sister of P-glycoprotein/bile salt export pump) mediates the elimination of cytotoxic bile salts from liver cells to bile, and, therefore, plays a critical role in the generation of bile flow.	Bile Acids and Salts	133-143	ATP binding cassette subfamily B member 11	Homo sapiens	72-93
17264802-5	2007	Reference and mutant BSEP were expressed in Sf9 cells and ATP-dependent transport of [H]-taurocholate was measured in a rapid filtration assay.	Adenosine Triphosphate	58-61	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
17264802-5	2007	Reference and mutant BSEP were expressed in Sf9 cells and ATP-dependent transport of [H]-taurocholate was measured in a rapid filtration assay.	[h]-taurocholate	85-101	ATP binding cassette subfamily B member 11	Homo sapiens	21-25
16871584-2	2006	We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter bile salt export pump (BSEP) and mutation in ABCB11, encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)--or "neonatal hepatitis" suggesting PFIC--that was associated with HCC in young children.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	150-171
16890614-11	2006	Reduced bile salt secretion through BSEP may explain the persistence of elevated bile salt levels and incomplete efficacy of ursodeoxycholate treatment.	Bile Acids and Salts	8-17	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
16890614-11	2006	Reduced bile salt secretion through BSEP may explain the persistence of elevated bile salt levels and incomplete efficacy of ursodeoxycholate treatment.	Bile Acids and Salts	81-90	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
16890614-11	2006	Reduced bile salt secretion through BSEP may explain the persistence of elevated bile salt levels and incomplete efficacy of ursodeoxycholate treatment.	Ursodeoxycholic Acid	125-141	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
16760228-5	2006	Because fluorescent substrates allow the development of a high-throughput screening method, we examined the transport by NTCP and BSEP of fluorescent bile acids as well as taurocholate.	Bile Acids and Salts	150-160	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
16760228-6	2006	The aminofluorescein-tagged bile acids, chenodeoxycholylglycylamidofluorescein and cholylglycylamidofluorescein, were substrates of both NTCP and BSEP, and their basal-to-apical transport rates across coexpressing cell monolayers were 4.3 to 4.5 times those of the vector control, although smaller than for taurocholate.	aminofluorescein	4-20	ATP binding cassette subfamily B member 11	Homo sapiens	146-150
16760228-6	2006	The aminofluorescein-tagged bile acids, chenodeoxycholylglycylamidofluorescein and cholylglycylamidofluorescein, were substrates of both NTCP and BSEP, and their basal-to-apical transport rates across coexpressing cell monolayers were 4.3 to 4.5 times those of the vector control, although smaller than for taurocholate.	Bile Acids and Salts	28-38	ATP binding cassette subfamily B member 11	Homo sapiens	146-150
16760228-6	2006	The aminofluorescein-tagged bile acids, chenodeoxycholylglycylamidofluorescein and cholylglycylamidofluorescein, were substrates of both NTCP and BSEP, and their basal-to-apical transport rates across coexpressing cell monolayers were 4.3 to 4.5 times those of the vector control, although smaller than for taurocholate.	chenodeoxycholylglycylamidofluorescein	40-78	ATP binding cassette subfamily B member 11	Homo sapiens	146-150
16760228-6	2006	The aminofluorescein-tagged bile acids, chenodeoxycholylglycylamidofluorescein and cholylglycylamidofluorescein, were substrates of both NTCP and BSEP, and their basal-to-apical transport rates across coexpressing cell monolayers were 4.3 to 4.5 times those of the vector control, although smaller than for taurocholate.	cholylglycylamidofluorescein	50-78	ATP binding cassette subfamily B member 11	Homo sapiens	146-150
16760228-6	2006	The aminofluorescein-tagged bile acids, chenodeoxycholylglycylamidofluorescein and cholylglycylamidofluorescein, were substrates of both NTCP and BSEP, and their basal-to-apical transport rates across coexpressing cell monolayers were 4.3 to 4.5 times those of the vector control, although smaller than for taurocholate.	Taurocholic Acid	307-319	ATP binding cassette subfamily B member 11	Homo sapiens	146-150
16760228-7	2006	The well known cholestatic drugs, rifampicin, rifamycin SV, glibenclamide, and cyclosporin A, reduced the basal-to-apical transport and the apical efflux clearance of taurocholate across NTCP- and BSEP-coexpressing cell monolayers.	Rifampin	34-44	ATP binding cassette subfamily B member 11	Homo sapiens	197-201
16760228-7	2006	The well known cholestatic drugs, rifampicin, rifamycin SV, glibenclamide, and cyclosporin A, reduced the basal-to-apical transport and the apical efflux clearance of taurocholate across NTCP- and BSEP-coexpressing cell monolayers.	Glyburide	60-73	ATP binding cassette subfamily B member 11	Homo sapiens	197-201
16760228-7	2006	The well known cholestatic drugs, rifampicin, rifamycin SV, glibenclamide, and cyclosporin A, reduced the basal-to-apical transport and the apical efflux clearance of taurocholate across NTCP- and BSEP-coexpressing cell monolayers.	Cyclosporine	79-92	ATP binding cassette subfamily B member 11	Homo sapiens	197-201
16760228-7	2006	The well known cholestatic drugs, rifampicin, rifamycin SV, glibenclamide, and cyclosporin A, reduced the basal-to-apical transport and the apical efflux clearance of taurocholate across NTCP- and BSEP-coexpressing cell monolayers.	Taurocholic Acid	167-179	ATP binding cassette subfamily B member 11	Homo sapiens	197-201
16763017-1	2006	Biliary excretion of bile salts and other bile constituents from hepatocytes is mediated by the apical (canalicular) transporters P-glycoprotein 3 (MDR3, ABCB4) and the bile salt export pump (ABCB11).	Bile Acids and Salts	21-31	ATP binding cassette subfamily B member 11	Homo sapiens	169-190
16763017-1	2006	Biliary excretion of bile salts and other bile constituents from hepatocytes is mediated by the apical (canalicular) transporters P-glycoprotein 3 (MDR3, ABCB4) and the bile salt export pump (ABCB11).	Bile Acids and Salts	21-31	ATP binding cassette subfamily B member 11	Homo sapiens	192-198
16871584-2	2006	We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter bile salt export pump (BSEP) and mutation in ABCB11, encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC)--or "neonatal hepatitis" suggesting PFIC--that was associated with HCC in young children.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	173-177
16749857-1	2006	Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby plays a critical role in the generation of bile flow.	Bile Acids and Salts	86-96	ATP binding cassette subfamily B member 11	Homo sapiens	39-45
16819395-3	2006	The predominant transporter is the bile salt excretory pump (BSEP, ABCB11), a member of the adenosine triphosphate-binding cassette (ABC) family of transporters.	Bile Acids and Salts	35-44	ATP binding cassette subfamily B member 11	Homo sapiens	61-65
16819395-3	2006	The predominant transporter is the bile salt excretory pump (BSEP, ABCB11), a member of the adenosine triphosphate-binding cassette (ABC) family of transporters.	Bile Acids and Salts	35-44	ATP binding cassette subfamily B member 11	Homo sapiens	67-73
16819395-7	2006	In cloning of the BSEP gene, we found a binding site in the promoter for the farnesoid X receptor (FXR), a nuclear receptor for bile acids.	Bile Acids and Salts	128-138	ATP binding cassette subfamily B member 11	Homo sapiens	18-22
16819395-8	2006	FXR activity requires heterodimerization with the 9-cis retinoid receptor (RXR alpha), and when bound by bile acids and retinoic acid, the complex effectively activates the transcription of BSEP.	Bile Acids and Salts	105-115	ATP binding cassette subfamily B member 11	Homo sapiens	190-194
16819395-8	2006	FXR activity requires heterodimerization with the 9-cis retinoid receptor (RXR alpha), and when bound by bile acids and retinoic acid, the complex effectively activates the transcription of BSEP.	Tretinoin	120-133	ATP binding cassette subfamily B member 11	Homo sapiens	190-194
16819395-11	2006	Chromatin immunoprecipitation showed that the bile acid-dependent activation of the human BSEP is associated with a simultaneous increase of FXR and CARM1 occupation of the BSEP promoter.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	90-94
16819395-11	2006	Chromatin immunoprecipitation showed that the bile acid-dependent activation of the human BSEP is associated with a simultaneous increase of FXR and CARM1 occupation of the BSEP promoter.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	173-177
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
16819395-12	2006	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
16458994-0	2006	Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy.	Progesterone	67-79	ATP binding cassette subfamily B member 11	Homo sapiens	42-63
16458994-3	2006	Whether PM4-S inhibited the bile salt export pump (BSEP) was investigated.	pm4-s	8-13	ATP binding cassette subfamily B member 11	Homo sapiens	28-49
16458994-3	2006	Whether PM4-S inhibited the bile salt export pump (BSEP) was investigated.	pm4-s	8-13	ATP binding cassette subfamily B member 11	Homo sapiens	51-55
16458994-4	2006	Radiolabeled methylesters (ME) of cholic acid and chenodeoxycholic acid were taken up by Xenopus laevis oocytes co-expressing rat BSEP and human carboxylesterase-1 (CES1), efficiently hydrolyzed to free BAs by CES1 and subsequently exported by BSEP.	methionylglutamic acid	27-29	ATP binding cassette subfamily B member 11	Homo sapiens	244-248
16458994-4	2006	Radiolabeled methylesters (ME) of cholic acid and chenodeoxycholic acid were taken up by Xenopus laevis oocytes co-expressing rat BSEP and human carboxylesterase-1 (CES1), efficiently hydrolyzed to free BAs by CES1 and subsequently exported by BSEP.	Cholic Acid	34-45	ATP binding cassette subfamily B member 11	Homo sapiens	244-248
16458994-4	2006	Radiolabeled methylesters (ME) of cholic acid and chenodeoxycholic acid were taken up by Xenopus laevis oocytes co-expressing rat BSEP and human carboxylesterase-1 (CES1), efficiently hydrolyzed to free BAs by CES1 and subsequently exported by BSEP.	Chenodeoxycholic Acid	50-71	ATP binding cassette subfamily B member 11	Homo sapiens	244-248
16458994-6	2006	In contrast, estradiol 17beta-D-glucuronide and several progesterone metabolites, including PM4-S, induced a marked non-competitive trans-inhibition of BSEP-mediated BA efflux (Ki=20-60 microM).	Estradiol	13-22	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
16458994-6	2006	In contrast, estradiol 17beta-D-glucuronide and several progesterone metabolites, including PM4-S, induced a marked non-competitive trans-inhibition of BSEP-mediated BA efflux (Ki=20-60 microM).	17beta-d-glucuronide	23-43	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
16458994-6	2006	In contrast, estradiol 17beta-D-glucuronide and several progesterone metabolites, including PM4-S, induced a marked non-competitive trans-inhibition of BSEP-mediated BA efflux (Ki=20-60 microM).	Progesterone	56-68	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
16458994-6	2006	In contrast, estradiol 17beta-D-glucuronide and several progesterone metabolites, including PM4-S, induced a marked non-competitive trans-inhibition of BSEP-mediated BA efflux (Ki=20-60 microM).	pm4-s	92-97	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
16458994-10	2006	CONCLUSIONS: Several estrogens and progesterone metabolites are able to induce trans-inhibition of BSEP and the subsequent toxicity induced by the accumulation of BAs, which may play a role in the etiopathogenesis of ICP.	Barium	163-166	ATP binding cassette subfamily B member 11	Homo sapiens	99-103
16488578-5	2006	In addition, expression of canalicular transporters in HepaRG cells was found to be up-regulated by known inducers of transporters such as rifampicin, phenobarbital and chenodeoxycholate acting on P-glycoprotein, MRP2 and BSEP, respectively.	Rifampin	139-149	ATP binding cassette subfamily B member 11	Homo sapiens	222-226
16488578-5	2006	In addition, expression of canalicular transporters in HepaRG cells was found to be up-regulated by known inducers of transporters such as rifampicin, phenobarbital and chenodeoxycholate acting on P-glycoprotein, MRP2 and BSEP, respectively.	Phenobarbital	151-164	ATP binding cassette subfamily B member 11	Homo sapiens	222-226
16488578-5	2006	In addition, expression of canalicular transporters in HepaRG cells was found to be up-regulated by known inducers of transporters such as rifampicin, phenobarbital and chenodeoxycholate acting on P-glycoprotein, MRP2 and BSEP, respectively.	Chenodeoxycholic Acid	169-186	ATP binding cassette subfamily B member 11	Homo sapiens	222-226
16749857-0	2006	High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis.	Bile Acids and Salts	89-98	ATP binding cassette subfamily B member 11	Homo sapiens	81-87
16749857-1	2006	Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby plays a critical role in the generation of bile flow.	Bile Acids and Salts	86-96	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
16749857-1	2006	Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby plays a critical role in the generation of bile flow.	Bile Acids and Salts	86-96	ATP binding cassette subfamily B member 11	Homo sapiens	52-56
16749857-3	2006	Plasma membrane vesicles prepared from insect cells overexpressing human ABCB11 were used to measure the ATP-dependent transport of [14C]taurocholate.	Adenosine Triphosphate	105-108	ATP binding cassette subfamily B member 11	Homo sapiens	73-79
16749857-3	2006	Plasma membrane vesicles prepared from insect cells overexpressing human ABCB11 were used to measure the ATP-dependent transport of [14C]taurocholate.	14c]taurocholate	133-149	ATP binding cassette subfamily B member 11	Homo sapiens	73-79
16332456-1	2005	The bile salt export pump (BSEP) of hepatocyte secretes conjugated bile salts across the canalicular membrane in an ATP-dependent manner.	Bile Acids and Salts	67-77	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
16282361-7	2006	K(m) values of the bile acids for ABCC4 were in a range similar to those reported for the canalicular bile salt export pump ABCB11.	Bile Acids and Salts	19-29	ATP binding cassette subfamily B member 11	Homo sapiens	124-130
16282361-7	2006	K(m) values of the bile acids for ABCC4 were in a range similar to those reported for the canalicular bile salt export pump ABCB11.	Bile Acids and Salts	102-111	ATP binding cassette subfamily B member 11	Homo sapiens	124-130
16282361-8	2006	Under physiological conditions, the sinusoidal ABCC4 may compete with canalicular ABCB11 for bile acids and thereby play a key role in determining the hepatocyte concentration of bile acids.	Bile Acids and Salts	93-103	ATP binding cassette subfamily B member 11	Homo sapiens	82-88
16282361-8	2006	Under physiological conditions, the sinusoidal ABCC4 may compete with canalicular ABCB11 for bile acids and thereby play a key role in determining the hepatocyte concentration of bile acids.	Bile Acids and Salts	179-189	ATP binding cassette subfamily B member 11	Homo sapiens	82-88
16332456-4	2005	ATP-dependent uptake of radiolabeled glycine-, taurine-conjugated bile salts, and [(3)H]cholate was observed when hBSEP or rBsep was expressed.	Glycine	37-44	ATP binding cassette subfamily B member 11	Homo sapiens	114-119
16332456-4	2005	ATP-dependent uptake of radiolabeled glycine-, taurine-conjugated bile salts, and [(3)H]cholate was observed when hBSEP or rBsep was expressed.	Taurine	47-54	ATP binding cassette subfamily B member 11	Homo sapiens	114-119
16371446-0	2006	Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.	oxysterol 22(r)-hydroxycholesterol	0-34	ATP binding cassette subfamily B member 11	Homo sapiens	65-86
16371446-2	2006	Bile salt export pump (BSEP) is responsible for canalicular secretion of bile acids and is tightly regulated by its substrates bile acids through nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	73-83	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
16371446-2	2006	Bile salt export pump (BSEP) is responsible for canalicular secretion of bile acids and is tightly regulated by its substrates bile acids through nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	73-83	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
16371446-2	2006	Bile salt export pump (BSEP) is responsible for canalicular secretion of bile acids and is tightly regulated by its substrates bile acids through nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	127-137	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
16371446-2	2006	Bile salt export pump (BSEP) is responsible for canalicular secretion of bile acids and is tightly regulated by its substrates bile acids through nuclear receptor farnesoid X receptor (FXR).	Bile Acids and Salts	127-137	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
16371446-3	2006	In a microarray study using human hepatocytes, BSEP was markedly induced not only by chenodeoxycholic acid (CDCA) but also by oxysterol 22(R)-hydroxycholesterol [22(R)-OHC].	Chenodeoxycholic Acid	85-106	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
16371446-3	2006	In a microarray study using human hepatocytes, BSEP was markedly induced not only by chenodeoxycholic acid (CDCA) but also by oxysterol 22(R)-hydroxycholesterol [22(R)-OHC].	Chenodeoxycholic Acid	108-112	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
16371446-3	2006	In a microarray study using human hepatocytes, BSEP was markedly induced not only by chenodeoxycholic acid (CDCA) but also by oxysterol 22(R)-hydroxycholesterol [22(R)-OHC].	oxysterol 22(r)-hydroxycholesterol	126-160	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
16371446-3	2006	In a microarray study using human hepatocytes, BSEP was markedly induced not only by chenodeoxycholic acid (CDCA) but also by oxysterol 22(R)-hydroxycholesterol [22(R)-OHC].	22(r)-ohc	162-171	ATP binding cassette subfamily B member 11	Homo sapiens	47-51
16371446-4	2006	We hypothesized that the expression of BSEP was induced by oxysterols through activation of LXR.	Oxysterols	59-69	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
16371446-6	2006	The level of BSEP mRNA was increased as much as 5-fold upon oxysterol induction.	Oxysterols	60-69	ATP binding cassette subfamily B member 11	Homo sapiens	13-17
16371446-7	2006	In contrast to our hypothesis, the oxysterol-induced up-regulation of BSEP is mediated through FXR but not LXR.	Oxysterols	35-44	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
16371446-9	2006	Mutation of the FXR element IR1 in the BSEP promoter significantly reduced its ability to respond to oxysterol induction.	Oxysterols	101-110	ATP binding cassette subfamily B member 11	Homo sapiens	39-43
16410371-3	2006	We found that nefazodone caused a strong inhibition of BSEP (IC(50) = 9 microM), inhibition of taurocholate efflux in human hepatocytes (IC(50) = 14 microM), and a transient increase in rat serum bile acids 1 h after oral drug administration.	nefazodone	14-24	ATP binding cassette subfamily B member 11	Homo sapiens	55-59
16290310-1	2006	We describe a PFIC2 patient with a good response to ursodeoxycholic acid for 9 years.	Ursodeoxycholic Acid	52-72	ATP binding cassette subfamily B member 11	Homo sapiens	14-19
16332456-4	2005	ATP-dependent uptake of radiolabeled glycine-, taurine-conjugated bile salts, and [(3)H]cholate was observed when hBSEP or rBsep was expressed.	Bile Acids and Salts	66-76	ATP binding cassette subfamily B member 11	Homo sapiens	114-119
16332456-1	2005	The bile salt export pump (BSEP) of hepatocyte secretes conjugated bile salts across the canalicular membrane in an ATP-dependent manner.	Bile Acids and Salts	67-77	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
16332456-4	2005	ATP-dependent uptake of radiolabeled glycine-, taurine-conjugated bile salts, and [(3)H]cholate was observed when hBSEP or rBsep was expressed.	[(3)h]cholate	82-95	ATP binding cassette subfamily B member 11	Homo sapiens	114-119
16332456-5	2005	Comparison of initial uptake rates indicated that for both transporters, taurine-conjugated bile salts were transported more rapidly than glycine-conjugated bile salts, however, hBSEP transported glycine conjugates to an extent that was approximately 2-fold greater than rBsep.	Taurine	73-80	ATP binding cassette subfamily B member 11	Homo sapiens	178-183
16332456-1	2005	The bile salt export pump (BSEP) of hepatocyte secretes conjugated bile salts across the canalicular membrane in an ATP-dependent manner.	Adenosine Triphosphate	116-119	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
16332456-5	2005	Comparison of initial uptake rates indicated that for both transporters, taurine-conjugated bile salts were transported more rapidly than glycine-conjugated bile salts, however, hBSEP transported glycine conjugates to an extent that was approximately 2-fold greater than rBsep.	Bile Acids and Salts	92-102	ATP binding cassette subfamily B member 11	Homo sapiens	178-183
16332456-5	2005	Comparison of initial uptake rates indicated that for both transporters, taurine-conjugated bile salts were transported more rapidly than glycine-conjugated bile salts, however, hBSEP transported glycine conjugates to an extent that was approximately 2-fold greater than rBsep.	Glycine	138-145	ATP binding cassette subfamily B member 11	Homo sapiens	178-183
16332456-1	2005	The bile salt export pump (BSEP) of hepatocyte secretes conjugated bile salts across the canalicular membrane in an ATP-dependent manner.	Adenosine Triphosphate	116-119	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
16332456-5	2005	Comparison of initial uptake rates indicated that for both transporters, taurine-conjugated bile salts were transported more rapidly than glycine-conjugated bile salts, however, hBSEP transported glycine conjugates to an extent that was approximately 2-fold greater than rBsep.	Bile Acids and Salts	157-167	ATP binding cassette subfamily B member 11	Homo sapiens	178-183
16332456-4	2005	ATP-dependent uptake of radiolabeled glycine-, taurine-conjugated bile salts, and [(3)H]cholate was observed when hBSEP or rBsep was expressed.	Adenosine Triphosphate	0-3	ATP binding cassette subfamily B member 11	Homo sapiens	114-119
16332456-5	2005	Comparison of initial uptake rates indicated that for both transporters, taurine-conjugated bile salts were transported more rapidly than glycine-conjugated bile salts, however, hBSEP transported glycine conjugates to an extent that was approximately 2-fold greater than rBsep.	Glycine	196-203	ATP binding cassette subfamily B member 11	Homo sapiens	178-183
16332456-8	2005	In conclusion, both hBSEP and rBsep transport taurine-conjugated bile salts better than glycine-conjugated bile salts, but hBSEP transports glycine conjugates to a greater extent as compared to rBsep.	Bile Acids and Salts	65-75	ATP binding cassette subfamily B member 11	Homo sapiens	20-25
16332456-8	2005	In conclusion, both hBSEP and rBsep transport taurine-conjugated bile salts better than glycine-conjugated bile salts, but hBSEP transports glycine conjugates to a greater extent as compared to rBsep.	Glycine	140-147	ATP binding cassette subfamily B member 11	Homo sapiens	123-128
16039748-0	2005	Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis.	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	81-87
16214890-4	2005	In contrast, apical ATP-binding-cassette (ABC) transporters, which are required for energy-dependent biliary secretion of bile acids (ABCB11), phospholipids (ABCB4), and nonbile acid organic anions (ABCC2), lack initial residence in the basolateral plasma membrane and traffic directly from Golgi membranes to the canalicular membrane.	Bile Acids and Salts	122-132	ATP binding cassette subfamily B member 11	Homo sapiens	134-140
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	5-14	ATP binding cassette subfamily B member 11	Homo sapiens	313-334
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	5-14	ATP binding cassette subfamily B member 11	Homo sapiens	336-340
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	313-334
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	336-340
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	244-254	ATP binding cassette subfamily B member 11	Homo sapiens	313-334
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	244-254	ATP binding cassette subfamily B member 11	Homo sapiens	336-340
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	313-334
16178789-6	2005	Thus bile acid-activated FXR directly induces expression of Small Heterodimer Partner (SHP), a nuclear receptor that suppresses bile acid biosynthesis down-regulates the Na+ taurocholate cotransport peptide (NTCP), a pump depicted to transport bile acids from the lumen into hepatocyte, and induces expression of bile salt export pump (BSEP), the principal bile acid efflux transporter in the liver.	Bile Acids and Salts	128-137	ATP binding cassette subfamily B member 11	Homo sapiens	336-340
16039748-1	2005	BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11) causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as PFIC2 and BRIC2, respectively.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	68-72
16039748-1	2005	BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11) causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as PFIC2 and BRIC2, respectively.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	74-80
16039748-1	2005	BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11) causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as PFIC2 and BRIC2, respectively.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	174-179
16039748-1	2005	BACKGROUND/AIMS: Inherited dysfunction of the bile salt export pump BSEP (ABCB11) causes a progressive and a benign form of familial intrahepatic cholestasis, denominated as PFIC2 and BRIC2, respectively.	Bile Acids and Salts	46-55	ATP binding cassette subfamily B member 11	Homo sapiens	184-189
16039748-7	2005	In BRIC2, taurocholate transport was decreased to 13% and 20% of reference levels for R432T and E297G, respectively.	Taurocholic Acid	10-22	ATP binding cassette subfamily B member 11	Homo sapiens	3-8
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	120-125	ATP binding cassette subfamily B member 11	Homo sapiens	363-367
16109175-5	2005	RESULTS: Using RT-PCR, immunoblotting and confocal immunofluorescence, we showed that WIF-B cells express the aquaporin water channels that facilitate the osmotically driven water movements in the liver, i.e. AQP8, AQP9, and AQP0; as well as the key solute transporters involved in the generation of canalicular osmotic gradients, i.e., the bile salt export pump Bsep, the organic anion transporter Mrp2 and the chloride bicarbonate exchanger AE2.	Water	174-179	ATP binding cassette subfamily B member 11	Homo sapiens	363-367
15791618-1	2005	Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a mutation in the bile salt export pump (BSEP/ABCB11) gene.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	0-52
15901796-0	2005	Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.	Pravastatin	76-87	ATP binding cassette subfamily B member 11	Homo sapiens	0-21
15901796-0	2005	Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.	Pravastatin	76-87	ATP binding cassette subfamily B member 11	Homo sapiens	23-27
15901796-0	2005	Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin.	Pravastatin	76-87	ATP binding cassette subfamily B member 11	Homo sapiens	28-34
15901796-3	2005	It is generally accepted that the bile salt export pump (BSEP/ABCB11) mainly transports bile acids and plays an indispensable role in their biliary excretion.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	34-55
15901796-3	2005	It is generally accepted that the bile salt export pump (BSEP/ABCB11) mainly transports bile acids and plays an indispensable role in their biliary excretion.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
15901796-3	2005	It is generally accepted that the bile salt export pump (BSEP/ABCB11) mainly transports bile acids and plays an indispensable role in their biliary excretion.	Bile Acids and Salts	88-98	ATP binding cassette subfamily B member 11	Homo sapiens	62-68
15901796-4	2005	Interestingly, we found that BSEP could accept pravastatin as a substrate.	Pravastatin	47-58	ATP binding cassette subfamily B member 11	Homo sapiens	29-33
15901796-5	2005	Significant ATP-dependent uptake of pravastatin by human BSEP (hBSEP)- and rat BSEP (rBsep)-expressing membrane vesicles was observed, and the ratio of the uptake activity of pravastatin to that of taurocholic acid (TCA) by hBSEP was 3.3-fold higher than that by rBsep.	Adenosine Triphosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
15901796-5	2005	Significant ATP-dependent uptake of pravastatin by human BSEP (hBSEP)- and rat BSEP (rBsep)-expressing membrane vesicles was observed, and the ratio of the uptake activity of pravastatin to that of taurocholic acid (TCA) by hBSEP was 3.3-fold higher than that by rBsep.	Adenosine Triphosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	63-68
15901796-5	2005	Significant ATP-dependent uptake of pravastatin by human BSEP (hBSEP)- and rat BSEP (rBsep)-expressing membrane vesicles was observed, and the ratio of the uptake activity of pravastatin to that of taurocholic acid (TCA) by hBSEP was 3.3-fold higher than that by rBsep.	Adenosine Triphosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	224-229
15901796-5	2005	Significant ATP-dependent uptake of pravastatin by human BSEP (hBSEP)- and rat BSEP (rBsep)-expressing membrane vesicles was observed, and the ratio of the uptake activity of pravastatin to that of taurocholic acid (TCA) by hBSEP was 3.3-fold higher than that by rBsep.	Pravastatin	36-47	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
15901796-5	2005	Significant ATP-dependent uptake of pravastatin by human BSEP (hBSEP)- and rat BSEP (rBsep)-expressing membrane vesicles was observed, and the ratio of the uptake activity of pravastatin to that of taurocholic acid (TCA) by hBSEP was 3.3-fold higher than that by rBsep.	Pravastatin	36-47	ATP binding cassette subfamily B member 11	Homo sapiens	63-68
15911693-6	2005	In the present study, we demonstrated that 6-ECDCA activates FXR to interacts with Protein Arginine Methyl-Transferase type I (PRMT1), which induces up-regulation of bile salt export pump (BSEP) and the small heterodimer partner (SHP) mRNA expression and causes a down-regulation of P450 cholesterol 7alpha-hydroxylase and Na(+) taurocholate cotransport peptide genes.	obeticholic acid	43-50	ATP binding cassette subfamily B member 11	Homo sapiens	166-187
15911693-6	2005	In the present study, we demonstrated that 6-ECDCA activates FXR to interacts with Protein Arginine Methyl-Transferase type I (PRMT1), which induces up-regulation of bile salt export pump (BSEP) and the small heterodimer partner (SHP) mRNA expression and causes a down-regulation of P450 cholesterol 7alpha-hydroxylase and Na(+) taurocholate cotransport peptide genes.	obeticholic acid	43-50	ATP binding cassette subfamily B member 11	Homo sapiens	189-193
15911693-7	2005	Chromatin immunoprecipitation assay suggests that 6-ECDCA induces both the recruitment of PRMT1 and the H4 methylation to the promoter of BSEP and SHP genes.	obeticholic acid	50-57	ATP binding cassette subfamily B member 11	Homo sapiens	138-142
15901796-6	2005	The K(m) value of pravastatin for hBSEP was 124 muM.	Pravastatin	18-29	ATP binding cassette subfamily B member 11	Homo sapiens	34-39
15901796-7	2005	A mutual inhibition study between TCA and pravastatin revealed that they competitively interact with hBSEP.	Taurocholic Acid	34-37	ATP binding cassette subfamily B member 11	Homo sapiens	101-106
15901796-7	2005	A mutual inhibition study between TCA and pravastatin revealed that they competitively interact with hBSEP.	Pravastatin	42-53	ATP binding cassette subfamily B member 11	Homo sapiens	101-106
15901796-8	2005	Several statins inhibited the hBSEP- and rBsep-mediated uptake of TCA; however, the specific uptake of other statins (cerivastatin, fluvastatin, and pitavastatin) by hBSEP and rBSEP was not detected.	Taurocholic Acid	66-69	ATP binding cassette subfamily B member 11	Homo sapiens	30-35
15901796-8	2005	Several statins inhibited the hBSEP- and rBsep-mediated uptake of TCA; however, the specific uptake of other statins (cerivastatin, fluvastatin, and pitavastatin) by hBSEP and rBSEP was not detected.	cerivastatin	118-130	ATP binding cassette subfamily B member 11	Homo sapiens	166-171
15901796-8	2005	Several statins inhibited the hBSEP- and rBsep-mediated uptake of TCA; however, the specific uptake of other statins (cerivastatin, fluvastatin, and pitavastatin) by hBSEP and rBSEP was not detected.	Fluvastatin	132-143	ATP binding cassette subfamily B member 11	Homo sapiens	166-171
15901796-8	2005	Several statins inhibited the hBSEP- and rBsep-mediated uptake of TCA; however, the specific uptake of other statins (cerivastatin, fluvastatin, and pitavastatin) by hBSEP and rBSEP was not detected.	pitavastatin	149-161	ATP binding cassette subfamily B member 11	Homo sapiens	166-171
15901796-9	2005	The inhibitory effects of hydrophilic statins (pravastatin and rosuvastatin) on the uptake of TCA by BSEP were relatively lower than those of lipophilic statins.	Pravastatin	47-58	ATP binding cassette subfamily B member 11	Homo sapiens	101-105
15901796-9	2005	The inhibitory effects of hydrophilic statins (pravastatin and rosuvastatin) on the uptake of TCA by BSEP were relatively lower than those of lipophilic statins.	Rosuvastatin Calcium	63-75	ATP binding cassette subfamily B member 11	Homo sapiens	101-105
15901796-9	2005	The inhibitory effects of hydrophilic statins (pravastatin and rosuvastatin) on the uptake of TCA by BSEP were relatively lower than those of lipophilic statins.	Taurocholic Acid	94-97	ATP binding cassette subfamily B member 11	Homo sapiens	101-105
15841457-7	2005	Serum bile salts were elevated to 276 +/- 233 and to 221 +/- 109 micromol/L in PFIC-2 and PFIC-3, respectively.	Bile Acids and Salts	6-16	ATP binding cassette subfamily B member 11	Homo sapiens	79-85
15841457-11	2005	Several mechanisms may contribute to elevated plasma bile salts in PFIC: reduced bile salt uptake via NTCP, OATP1B1, and OATP1B3, decreased BSEP-dependent secretion into bile, and increased transport back into plasma by MRP4.	Bile Acids and Salts	53-63	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
15841457-11	2005	Several mechanisms may contribute to elevated plasma bile salts in PFIC: reduced bile salt uptake via NTCP, OATP1B1, and OATP1B3, decreased BSEP-dependent secretion into bile, and increased transport back into plasma by MRP4.	Bile Acids and Salts	53-62	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
15791618-1	2005	Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a mutation in the bile salt export pump (BSEP/ABCB11) gene.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	54-59
15791618-1	2005	Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a mutation in the bile salt export pump (BSEP/ABCB11) gene.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	115-119
15791618-1	2005	Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by a mutation in the bile salt export pump (BSEP/ABCB11) gene.	Bile Acids and Salts	92-101	ATP binding cassette subfamily B member 11	Homo sapiens	120-126
15581596-3	2005	Bile acids are excreted mainly via the bile salt export pump (BSEP, ABCB11).	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	39-60
15581596-3	2005	Bile acids are excreted mainly via the bile salt export pump (BSEP, ABCB11).	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	62-66
15581596-3	2005	Bile acids are excreted mainly via the bile salt export pump (BSEP, ABCB11).	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	68-74
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Bile Acids and Salts	37-46	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
15471871-1	2004	In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter.	Adenosine Triphosphate	261-264	ATP binding cassette subfamily B member 11	Homo sapiens	175-196
15471871-1	2004	In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter.	Adenosine Triphosphate	261-264	ATP binding cassette subfamily B member 11	Homo sapiens	198-202
15471871-1	2004	In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter.	Bile Acids and Salts	287-296	ATP binding cassette subfamily B member 11	Homo sapiens	175-196
15471871-1	2004	In this study we demonstrate that the class II nuclear hormone receptor, farnesoid X-receptor (FXR), incorporates histone methyltransferase activity within the gene locus for bile salt export pump (BSEP), a well established FXR target gene that functions as an ATP-dependent canalicular bile acid transporter.	Bile Acids and Salts	287-296	ATP binding cassette subfamily B member 11	Homo sapiens	198-202
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Arginine	102-105	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
15471871-5	2004	The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP.	Lysine	125-128	ATP binding cassette subfamily B member 11	Homo sapiens	32-36
15471871-7	2004	Induction of endogenous BSEP mRNA and Arg-17 methylation by FXR regulatory element ligand, CDCA, requires CARM1 activity.	Chenodeoxycholic Acid	91-95	ATP binding cassette subfamily B member 11	Homo sapiens	24-28
15578267-2	2004	Identification of the bile salt export pump (BSEP, ABCB11) as the main adenosine-triphosphate-dependent bile salt transporter in mammalian liver has led to a greater understanding of the biliary bile salt secretory process and its regulation.	Bile Acids and Salts	22-31	ATP binding cassette subfamily B member 11	Homo sapiens	45-49
15578267-2	2004	Identification of the bile salt export pump (BSEP, ABCB11) as the main adenosine-triphosphate-dependent bile salt transporter in mammalian liver has led to a greater understanding of the biliary bile salt secretory process and its regulation.	Bile Acids and Salts	22-31	ATP binding cassette subfamily B member 11	Homo sapiens	51-57
15307955-9	2004	The pattern of BSEP and kininogen regulation by PUFAs is closely similar to that of the guggulsterone, previously reported as a selective bile acid receptor modulator.	pregna-4,17-diene-3,16-dione	88-101	ATP binding cassette subfamily B member 11	Homo sapiens	15-19
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Adenosine Triphosphate	49-52	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Adenosine Triphosphate	49-52	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Adenosine Triphosphate	49-52	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Bile Acids and Salts	82-92	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Bile Acids and Salts	82-92	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
15121884-1	2004	The bile salt export pump (BSEP, ABCB11) couples ATP hydrolysis with transport of bile acids into the bile canaliculus of hepatocytes.	Bile Acids and Salts	82-92	ATP binding cassette subfamily B member 11	Homo sapiens	33-39
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Chenodeoxycholic Acid	172-176	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Chenodeoxycholic Acid	172-176	ATP binding cassette subfamily B member 11	Homo sapiens	157-161
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Deoxycholic Acid	173-176	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
14684751-8	2004	Consistently, CDCA increased BSEP mRNA by 750-fold in HepG2 cells, whereas DCA, CA, and UDCA induced BSEP mRNA by 250-, 75-, and 15-fold, respectively.	Chenodeoxycholic Acid	14-18	ATP binding cassette subfamily B member 11	Homo sapiens	29-33
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Bile Acids and Salts	37-46	ATP binding cassette subfamily B member 11	Homo sapiens	157-161
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
14684751-7	2004	In FXR transactivation assays with a bile salt export pump (BSEP) promoter-driven luciferase construct, bile acids showed distinct abilities to activate the BSEP promoter: CDCA, DCA, CA, and UDCA increased luciferase activity by 25-, 20-, 18-, and 8-fold, respectively.	Bile Acids and Salts	104-114	ATP binding cassette subfamily B member 11	Homo sapiens	157-161
14762791-4	2004	RESULTS: Ten percent of untreated HepG2 cells developed pseudocanaliculi, but only 15% of these pseudocanaliculi contained BSEP, which largely colocalized with the Golgi marker GM130.	gm130	177-182	ATP binding cassette subfamily B member 11	Homo sapiens	123-127
14999697-1	2004	Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in hereditary or acquired dysfunction of the canalicular membrane transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein type 3 (MDR3, ABCB4).	Bile Acids and Salts	226-235	ATP binding cassette subfamily B member 11	Homo sapiens	249-253
14999697-1	2004	Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are characterized by a cholestatic pattern of liver damage, also observed in hereditary or acquired dysfunction of the canalicular membrane transporters bile salt export pump (BSEP, ABCB11) and multidrug resistance protein type 3 (MDR3, ABCB4).	Bile Acids and Salts	226-235	ATP binding cassette subfamily B member 11	Homo sapiens	255-261
14762791-5	2004	Cycloheximide, an inhibitor of protein translation, induced a microtubule- and p38(MAP) kinase-dependent decrease of Golgi-associated BSEP, accompanied by a more than 2-fold increase in BSEP-positive pseudocanaliculi.	Cycloheximide	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	134-138
14762791-5	2004	Cycloheximide, an inhibitor of protein translation, induced a microtubule- and p38(MAP) kinase-dependent decrease of Golgi-associated BSEP, accompanied by a more than 2-fold increase in BSEP-positive pseudocanaliculi.	Cycloheximide	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	186-190
14762791-10	2004	Activation of p38(MAPK) by TUDC can recruit Golgi-associated BSEP in line with its choleretic action.	ursodoxicoltaurine	27-31	ATP binding cassette subfamily B member 11	Homo sapiens	61-65
14699511-4	2004	A key regulator of hepatocellular bile salt homeostasis is the bile acid receptor/farnesoid X receptor FXR, which activates transcription of the BSEP and OATP8 genes and of the small heterodimer partner 1 (SHP).	Bile Acids and Salts	34-43	ATP binding cassette subfamily B member 11	Homo sapiens	145-149
12967592-4	2003	Secondly, mutation in the bile salt exporting pump (BSEP)/sister of P-glycoprotein (spgp) gene causes progressive familial intrahepatic cholestasis type 2 in human.	Bile Acids and Salts	26-35	ATP binding cassette subfamily B member 11	Homo sapiens	52-56
14672610-1	2004	BACKGROUND/AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC-2) patients have a defect in the hepatocanalicular bile salt secretion.	Bile Acids and Salts	127-136	ATP binding cassette subfamily B member 11	Homo sapiens	71-77
15696852-6	2004	The bile salt export pump (BSEP or ABCB11) regulates the excretion of bile salts into bile and mutations cause severe cholestasis.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
15696852-6	2004	The bile salt export pump (BSEP or ABCB11) regulates the excretion of bile salts into bile and mutations cause severe cholestasis.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
15696852-6	2004	The bile salt export pump (BSEP or ABCB11) regulates the excretion of bile salts into bile and mutations cause severe cholestasis.	Bile Acids and Salts	70-80	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
15696852-6	2004	The bile salt export pump (BSEP or ABCB11) regulates the excretion of bile salts into bile and mutations cause severe cholestasis.	Bile Acids and Salts	70-80	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
12967592-4	2003	Secondly, mutation in the bile salt exporting pump (BSEP)/sister of P-glycoprotein (spgp) gene causes progressive familial intrahepatic cholestasis type 2 in human.	Bile Acids and Salts	26-35	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
12559450-6	2003	Additionally, while bile acid synthesis is repressed, pool size is preserved by the action of FXR/RXR at both hepatic and intestinal levels, which genetically signals enhanced hepatocyte bile salt transport by the bile salt export pump (BSEP) and the ileal bile acid binding protein (IBABP) for ileal reabsorption.	Bile Acids and Salts	187-196	ATP binding cassette subfamily B member 11	Homo sapiens	214-235
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	166-170
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	172-178
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	166-170
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	172-178
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	166-170
12663868-2	2003	The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).	Bile Acids and Salts	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	172-178
12519787-1	2003	The bile salt export pump (BSEP) plays an integral role in lipid homeostasis by regulating the canalicular excretion of bile acids.	Bile Acids and Salts	120-130	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
12519787-1	2003	The bile salt export pump (BSEP) plays an integral role in lipid homeostasis by regulating the canalicular excretion of bile acids.	Bile Acids and Salts	120-130	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
12519787-4	2003	Using real-time quantitative PCR and cotransfection reporter assays, we demonstrate that the RXR agonist LG100268 antagonizes induction of BSEP expression mediated by endogenous and synthetic FXR ligands, CDCA and GW4064, respectively.	LG 100268	105-113	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
12519787-4	2003	Using real-time quantitative PCR and cotransfection reporter assays, we demonstrate that the RXR agonist LG100268 antagonizes induction of BSEP expression mediated by endogenous and synthetic FXR ligands, CDCA and GW4064, respectively.	Chenodeoxycholic Acid	205-209	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
12519787-4	2003	Using real-time quantitative PCR and cotransfection reporter assays, we demonstrate that the RXR agonist LG100268 antagonizes induction of BSEP expression mediated by endogenous and synthetic FXR ligands, CDCA and GW4064, respectively.	GW 4064	214-220	ATP binding cassette subfamily B member 11	Homo sapiens	139-143
14708891-2	2003	In the liver, the sodium-dependent taurocholate transporter at the basolateral (sinusoidal) membrane and the bile salt export pump at the canalicular membrane mediate hepatic uptake and hepatobiliary secretion of bile salts.	Bile Acids and Salts	213-223	ATP binding cassette subfamily B member 11	Homo sapiens	109-130
14526284-7	2003	Baseline written and practical results discriminated PGY level (construct validity): PGY-2=PGY-3<PGY-4 on written pretest, PGY-2<PGY-3=PGY-4 on practical pretest.	pgy	53-56	ATP binding cassette subfamily B member 11	Homo sapiens	100-105
14526284-7	2003	Baseline written and practical results discriminated PGY level (construct validity): PGY-2=PGY-3<PGY-4 on written pretest, PGY-2<PGY-3=PGY-4 on practical pretest.	pgy-2	85-90	ATP binding cassette subfamily B member 11	Homo sapiens	100-105
12705905-0	2003	Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.	pregna-4,17-diene-3,16-dione	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	60-81
12705905-1	2003	Bile acids activate a nuclear receptor, farnesoid X receptor (FXR), that induces bile salt export pump (BSEP) but inhibits cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription in the liver.	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	81-102
12705905-1	2003	Bile acids activate a nuclear receptor, farnesoid X receptor (FXR), that induces bile salt export pump (BSEP) but inhibits cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription in the liver.	Bile Acids and Salts	0-10	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
12705905-3	2003	Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene.	pregna-4,17-diene-3,16-dione	114-127	ATP binding cassette subfamily B member 11	Homo sapiens	40-44
12705905-3	2003	Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene.	pregna-4,17-diene-3,16-dione	114-127	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
12705905-3	2003	Transient transfection assay of a human BSEP/luciferase reporter in HepG2 cells transfected with FXR reveals that guggulsterone strongly antagonizes bile acid induction of the BSEP gene.	Bile Acids and Salts	149-158	ATP binding cassette subfamily B member 11	Homo sapiens	176-180
12739759-7	2003	RESULTS: Several compounds were shown to inhibit BSEP active transport of the fluorescent substrates dihydrofluorescein and bodipy.	dihydrofluorescein	101-119	ATP binding cassette subfamily B member 11	Homo sapiens	49-53
12739759-7	2003	RESULTS: Several compounds were shown to inhibit BSEP active transport of the fluorescent substrates dihydrofluorescein and bodipy.	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	124-130	ATP binding cassette subfamily B member 11	Homo sapiens	49-53
12525500-0	2003	Guggulsterone is a farnesoid X receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump.	pregna-4,17-diene-3,16-dione	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	122-143
12525500-5	2003	In HepG2 cells, in the presence of an FXR agonist such as chenodeoxycholate or GW4064, GS enhanced endogenous BSEP expression with a maximum induction of 400-500% that induced by an FXR agonist alone.	Chenodeoxycholic Acid	58-75	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
12525500-5	2003	In HepG2 cells, in the presence of an FXR agonist such as chenodeoxycholate or GW4064, GS enhanced endogenous BSEP expression with a maximum induction of 400-500% that induced by an FXR agonist alone.	GW 4064	79-85	ATP binding cassette subfamily B member 11	Homo sapiens	110-114
12525500-12	2003	Taken together, these data suggest that guggulsterone defines a novel class of FXR ligands characterized by antagonist activities in coactivator association assays but with the ability to enhance the action of agonists on BSEP expression in vivo.	pregna-4,17-diene-3,16-dione	40-53	ATP binding cassette subfamily B member 11	Homo sapiens	222-226
12559450-6	2003	Additionally, while bile acid synthesis is repressed, pool size is preserved by the action of FXR/RXR at both hepatic and intestinal levels, which genetically signals enhanced hepatocyte bile salt transport by the bile salt export pump (BSEP) and the ileal bile acid binding protein (IBABP) for ileal reabsorption.	Bile Acids and Salts	187-196	ATP binding cassette subfamily B member 11	Homo sapiens	237-241
12052824-0	2002	Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.	Lithocholic Acid	0-16	ATP binding cassette subfamily B member 11	Homo sapiens	41-62
12404239-1	2002	BACKGROUND & AIMS: The bile salt export pump (BSEP) is the major bile salt transporter in the liver canalicular membrane.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	27-48
12404239-1	2002	BACKGROUND & AIMS: The bile salt export pump (BSEP) is the major bile salt transporter in the liver canalicular membrane.	Adenosine Monophosphate	12-15	ATP binding cassette subfamily B member 11	Homo sapiens	50-54
12404239-2	2002	Our aim was to determine the affinity of the human BSEP for bile salts and identify inhibitors.	Bile Acids and Salts	60-70	ATP binding cassette subfamily B member 11	Homo sapiens	51-55
12404239-10	2002	Cyclosporin A, rifampicin, and glibenclamide were proved to be competitive inhibitors of BSEP taurocholate transport, with inhibition constant values of 9.5 micromol/L, 31 micromol/L, and 27.5 micromol/L, respectively.	Cyclosporine	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	89-93
12404239-10	2002	Cyclosporin A, rifampicin, and glibenclamide were proved to be competitive inhibitors of BSEP taurocholate transport, with inhibition constant values of 9.5 micromol/L, 31 micromol/L, and 27.5 micromol/L, respectively.	Rifampin	15-25	ATP binding cassette subfamily B member 11	Homo sapiens	89-93
12404239-10	2002	Cyclosporin A, rifampicin, and glibenclamide were proved to be competitive inhibitors of BSEP taurocholate transport, with inhibition constant values of 9.5 micromol/L, 31 micromol/L, and 27.5 micromol/L, respectively.	Glyburide	31-44	ATP binding cassette subfamily B member 11	Homo sapiens	89-93
12404239-10	2002	Cyclosporin A, rifampicin, and glibenclamide were proved to be competitive inhibitors of BSEP taurocholate transport, with inhibition constant values of 9.5 micromol/L, 31 micromol/L, and 27.5 micromol/L, respectively.	Taurocholic Acid	94-106	ATP binding cassette subfamily B member 11	Homo sapiens	89-93
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	Bile Acids and Salts	49-59	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	Adenosine Triphosphate	66-69	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	Taurocholic Acid	130-142	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	Glycocholic Acid	168-180	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	Taurochenodeoxycholic Acid	207-229	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-9	2002	BSEP expressed in Sf9 cells transports different bile salts in an ATP-dependent manner with Michaelis constant values as follows: taurocholate, 7.9 +/- 2.1 micromol/L; glycocholate, 11.1 +/- 3.3 micromol/L; taurochenodeoxycholate, 4.8 +/- 1.7 micromol/L; tauroursodeoxycholate, 11.9 +/- 1.8 micromol/L.	ursodoxicoltaurine	255-276	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12404240-11	2002	CONCLUSIONS: This study characterizes human BSEP as an ATP-dependent bile salt export pump with transport properties similar to its rat and mouse orthologs.	Adenosine Triphosphate	55-58	ATP binding cassette subfamily B member 11	Homo sapiens	44-48
12404240-11	2002	CONCLUSIONS: This study characterizes human BSEP as an ATP-dependent bile salt export pump with transport properties similar to its rat and mouse orthologs.	Adenosine Triphosphate	55-58	ATP binding cassette subfamily B member 11	Homo sapiens	69-90
12052824-13	2002	These data suggest that the toxic and cholestatic effect of LCA in animals may result from its down-regulation of BSEP through FXR.	Lithocholic Acid	60-63	ATP binding cassette subfamily B member 11	Homo sapiens	114-118
15618715-5	2003	By comparing the inhibition potential between rat and human CMVs, the inhibition of BSEP- and MRP2-mediated transport by midecamycin and cyclosporin A was relatively similar whereas the inhibitory effect on BSEP-mediated transport by cloxacillin and glibenclamide was more marked in humans than in rats.	midecamycin	121-132	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
15618715-5	2003	By comparing the inhibition potential between rat and human CMVs, the inhibition of BSEP- and MRP2-mediated transport by midecamycin and cyclosporin A was relatively similar whereas the inhibitory effect on BSEP-mediated transport by cloxacillin and glibenclamide was more marked in humans than in rats.	Cyclosporine	137-150	ATP binding cassette subfamily B member 11	Homo sapiens	84-88
15618715-5	2003	By comparing the inhibition potential between rat and human CMVs, the inhibition of BSEP- and MRP2-mediated transport by midecamycin and cyclosporin A was relatively similar whereas the inhibitory effect on BSEP-mediated transport by cloxacillin and glibenclamide was more marked in humans than in rats.	Cloxacillin	234-245	ATP binding cassette subfamily B member 11	Homo sapiens	207-211
12052824-3	2002	BSEP is a target for inhibition and down-regulation by drugs and abnormal bile salt metabolites, and such inhibition and down-regulation may result in bile acid retention and intrahepatic cholestasis.	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12052824-3	2002	BSEP is a target for inhibition and down-regulation by drugs and abnormal bile salt metabolites, and such inhibition and down-regulation may result in bile acid retention and intrahepatic cholestasis.	Bile Acids and Salts	151-160	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
12052824-6	2002	Both the endogenous FXR agonist chenodeoxycholate (CDCA) and synthetic FXR ligand GW4064 effectively increased BSEP mRNA in both cell types.	Chenodeoxycholic Acid	32-49	ATP binding cassette subfamily B member 11	Homo sapiens	111-115
12052824-6	2002	Both the endogenous FXR agonist chenodeoxycholate (CDCA) and synthetic FXR ligand GW4064 effectively increased BSEP mRNA in both cell types.	Chenodeoxycholic Acid	51-55	ATP binding cassette subfamily B member 11	Homo sapiens	111-115
12052824-6	2002	Both the endogenous FXR agonist chenodeoxycholate (CDCA) and synthetic FXR ligand GW4064 effectively increased BSEP mRNA in both cell types.	GW 4064	82-88	ATP binding cassette subfamily B member 11	Homo sapiens	111-115
12052824-9	2002	In contrast to CDCA and GW4064, lithocholate (LCA), a hydrophobic bile acid and a potent inducer of cholestasis, strongly decreased BSEP expression.	Lithocholic Acid	32-44	ATP binding cassette subfamily B member 11	Homo sapiens	132-136
12052824-9	2002	In contrast to CDCA and GW4064, lithocholate (LCA), a hydrophobic bile acid and a potent inducer of cholestasis, strongly decreased BSEP expression.	Lithocholic Acid	46-49	ATP binding cassette subfamily B member 11	Homo sapiens	132-136
11870371-0	2002	Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.	Bile Acids and Salts	25-35	ATP binding cassette subfamily B member 11	Homo sapiens	110-131
12004058-11	2002	Consistent with the difference in FXR-LBD transactivation, CDCA induced endogenous expression of human BSEP by 10-12-fold and murine BSEP by 2-3-fold in primary hepatocytes.	Chenodeoxycholic Acid	59-63	ATP binding cassette subfamily B member 11	Homo sapiens	103-107
11870371-7	2002	Luciferase reporter gene assays showed that the ABCB11 promoter is positively controlled by FXR, RXRalpha, and bile salts in a concentration-dependent manner.	Bile Acids and Salts	111-121	ATP binding cassette subfamily B member 11	Homo sapiens	48-54
12004058-3	2002	In addition, hepatic bile acid export in humans is more dependent on the bile salt export pump (BSEP).	Bile Acids and Salts	21-30	ATP binding cassette subfamily B member 11	Homo sapiens	73-94
12004058-3	2002	In addition, hepatic bile acid export in humans is more dependent on the bile salt export pump (BSEP).	Bile Acids and Salts	21-30	ATP binding cassette subfamily B member 11	Homo sapiens	96-100
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Adenosine Triphosphate	56-78	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
11870371-10	2002	ABCB11 expression was induced by adding bile salts to the culture medium, and this effect was maximized by combining it with cotransfection of rFxr and hRXRalpha.	Bile Acids and Salts	40-50	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
11870371-11	2002	Reducing endogenous FXR levels using RNA interference fully repressed the bile salt-induced ABCB11 expression.	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	92-98
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Adenosine Triphosphate	56-78	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
11870371-12	2002	In conclusion, these results show that FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation of ABCB11 transcription.	Bile Acids and Salts	63-72	ATP binding cassette subfamily B member 11	Homo sapiens	120-126
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Adenosine Triphosphate	56-78	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
11870371-12	2002	In conclusion, these results show that FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene and that the cellular amount of FXR is critical for the level of activation of ABCB11 transcription.	Bile Acids and Salts	63-72	ATP binding cassette subfamily B member 11	Homo sapiens	211-217
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Bile Acids and Salts	102-112	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Bile Acids and Salts	102-112	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
11870371-1	2002	The bile salt export pump (BSEP or ABCB11) mediates the adenosine triphosphate-dependent transport of bile salts across the canalicular membrane of the hepatocyte.	Bile Acids and Salts	102-112	ATP binding cassette subfamily B member 11	Homo sapiens	35-41
11870371-3	2002	The aim of this study was to investigate the regulation of human ABCB11 gene transcription by bile salts.	Bile Acids and Salts	94-104	ATP binding cassette subfamily B member 11	Homo sapiens	65-71
12596388-5	2002	PFIC 2 disease is clinically similar to PFIC 1 but it has a different gene mutation causing a defect in the Bile Salt Export Pump (BSEP), exclusively expressed in the liver and involved in the canalicular secretion of bile acids.	Bile Acids and Salts	218-228	ATP binding cassette subfamily B member 11	Homo sapiens	0-6
12596388-5	2002	PFIC 2 disease is clinically similar to PFIC 1 but it has a different gene mutation causing a defect in the Bile Salt Export Pump (BSEP), exclusively expressed in the liver and involved in the canalicular secretion of bile acids.	Bile Acids and Salts	218-228	ATP binding cassette subfamily B member 11	Homo sapiens	108-129
12596388-5	2002	PFIC 2 disease is clinically similar to PFIC 1 but it has a different gene mutation causing a defect in the Bile Salt Export Pump (BSEP), exclusively expressed in the liver and involved in the canalicular secretion of bile acids.	Bile Acids and Salts	218-228	ATP binding cassette subfamily B member 11	Homo sapiens	131-135
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Adenosine Triphosphate	60-63	ATP binding cassette subfamily B member 11	Homo sapiens	36-42
12483266-5	2002	Amidated bile acids are excreted into bile by bile salt export pump (BSEP), and organic anions and bile acid sulfates and glucuronides are excreted by multidrug resistance protein 2 (MRP2).	Glucuronides	122-134	ATP binding cassette subfamily B member 11	Homo sapiens	69-73
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Adenosine Triphosphate	23-45	ATP binding cassette subfamily B member 11	Homo sapiens	85-106
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Adenosine Triphosphate	23-45	ATP binding cassette subfamily B member 11	Homo sapiens	108-112
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Adenosine Triphosphate	47-50	ATP binding cassette subfamily B member 11	Homo sapiens	85-106
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Adenosine Triphosphate	47-50	ATP binding cassette subfamily B member 11	Homo sapiens	108-112
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Bile Acids and Salts	196-206	ATP binding cassette subfamily B member 11	Homo sapiens	85-106
11745042-2	2001	The recently described adenosine triphosphate (ATP)-dependent bile acid transporter, bile salt export pump (BSEP), formerly called sister of p-glycoprotein, is responsible for active transport of bile acids across the hepatocyte canalicular membrane into bile.	Bile Acids and Salts	196-206	ATP binding cassette subfamily B member 11	Homo sapiens	108-112
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Adenosine Triphosphate	60-63	ATP binding cassette subfamily B member 11	Homo sapiens	4-28
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Adenosine Triphosphate	60-63	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	Bile Acids and Salts	40-49	ATP binding cassette subfamily B member 11	Homo sapiens	201-205
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	monoanionic bile salts	97-119	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	monoanionic bile salts	97-119	ATP binding cassette subfamily B member 11	Homo sapiens	201-205
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	Bile Acids and Salts	109-118	ATP binding cassette subfamily B member 11	Homo sapiens	183-187
11826283-3	2002	After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans).	Bile Acids and Salts	109-118	ATP binding cassette subfamily B member 11	Homo sapiens	201-205
12483266-5	2002	Amidated bile acids are excreted into bile by bile salt export pump (BSEP), and organic anions and bile acid sulfates and glucuronides are excreted by multidrug resistance protein 2 (MRP2).	Bile Acids and Salts	9-19	ATP binding cassette subfamily B member 11	Homo sapiens	46-67
12483266-5	2002	Amidated bile acids are excreted into bile by bile salt export pump (BSEP), and organic anions and bile acid sulfates and glucuronides are excreted by multidrug resistance protein 2 (MRP2).	Bile Acids and Salts	9-19	ATP binding cassette subfamily B member 11	Homo sapiens	69-73
11509573-3	2001	The potency and hierarchy of bile acids as ligands for the farnesyl/bile acid receptor (FXR/BAR) paralleled their ability to induce BSEP in human hepatocyte cultures.	Bile Acids and Salts	29-39	ATP binding cassette subfamily B member 11	Homo sapiens	132-136
11509573-4	2001	FXR:RXR heterodimers bound to IR1 elements and enhanced bile acid transcriptional activation of the mouse and human BSEP/SPGP promoters.	Bile Acids and Salts	56-65	ATP binding cassette subfamily B member 11	Homo sapiens	116-125
11509573-6	2001	Notably, the rank order of bile acids as CYP3A4 inducers and activators of pregnane X receptor/steroid and xenobiotic receptor (PXR/SXR) closely paralleled each other but was markedly different from their hierarchy and potency as inducers of BSEP in human hepatocytes.	Bile Acids and Salts	27-37	ATP binding cassette subfamily B member 11	Homo sapiens	242-246
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-97	ATP binding cassette subfamily B member 11	Homo sapiens	4-28
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-97	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-97	ATP binding cassette subfamily B member 11	Homo sapiens	36-42
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	4-28
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
11387316-1	2001	The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	36-42
11387316-2	2001	Recent studies have demonstrated that the expression of this transporter is sensitive to the flux of bile acids through the hepatocyte, possibly at the level of transcription of the BSEP gene.	Bile Acids and Salts	101-111	ATP binding cassette subfamily B member 11	Homo sapiens	182-186
11387316-3	2001	To determine the mechanisms underlying the regulation of BSEP by bile acids, the promoter of the BSEP gene was cloned.	Bile Acids and Salts	65-75	ATP binding cassette subfamily B member 11	Homo sapiens	57-61
11387316-3	2001	To determine the mechanisms underlying the regulation of BSEP by bile acids, the promoter of the BSEP gene was cloned.	Bile Acids and Salts	65-75	ATP binding cassette subfamily B member 11	Homo sapiens	97-101
11387316-8	2001	In HepG2 cells, co-transfection of FXR and RXR alpha is required to attain full transactivation of the BSEP promoter by bile acids.	Bile Acids and Salts	120-130	ATP binding cassette subfamily B member 11	Homo sapiens	103-107
11387316-11	2001	These results demonstrate a mechanism by which bile acids transcriptionally regulate the activity of the bile salt excretory pump, a critical component involved in the enterohepatic circulation of bile acids.	Bile Acids and Salts	47-57	ATP binding cassette subfamily B member 11	Homo sapiens	105-129
11387316-11	2001	These results demonstrate a mechanism by which bile acids transcriptionally regulate the activity of the bile salt excretory pump, a critical component involved in the enterohepatic circulation of bile acids.	Bile Acids and Salts	197-207	ATP binding cassette subfamily B member 11	Homo sapiens	105-129
11447010-1	2001	Bile secretion is a fundamental function of the liver of all vertebrates and is generated by ATP-dependent transport proteins at the canalicular membrane of hepatocytes, particularly by the bile salt export pump BSEP.	Adenosine Triphosphate	93-96	ATP binding cassette subfamily B member 11	Homo sapiens	212-216
11076396-6	2000	Transport across the canalicular membrane is the rate-limiting step in overall hepatocellular bile salt excretion and is mediated by the bile salt export pump (BSEP), a homologue of the P-glycoproteins or multidrug resistance gene products.	Bile Acids and Salts	94-103	ATP binding cassette subfamily B member 11	Homo sapiens	137-158
11447010-1	2001	Bile secretion is a fundamental function of the liver of all vertebrates and is generated by ATP-dependent transport proteins at the canalicular membrane of hepatocytes, particularly by the bile salt export pump BSEP.	Bile Acids and Salts	190-199	ATP binding cassette subfamily B member 11	Homo sapiens	212-216
11447010-5	2001	Expression of skate Bsep in Sf9 cells demonstrated a sixfold stimulation of ATP-dependent taurocholate transport compared with controls, with a Michaelis-Menten constant of 15 microM, which is comparable to rat Bsep.	Adenosine Triphosphate	76-79	ATP binding cassette subfamily B member 11	Homo sapiens	20-24
11447010-8	2001	These studies demonstrate that Bsep is a liver-specific ATP-dependent export pump that is highly conserved throughout evolution and provide insights into critical determinants for the function of this transporter in higher vertebrates.	Adenosine Triphosphate	56-59	ATP binding cassette subfamily B member 11	Homo sapiens	31-35
11309550-2	2001	In this study we investigated whether inhibition of the hepatocanalicular bile salt export pump (rodents, Bsep; humans, BSEP ABCB11) could account for bosentan-induced liver injury.	Bile Acids and Salts	74-83	ATP binding cassette subfamily B member 11	Homo sapiens	120-124
11309550-2	2001	In this study we investigated whether inhibition of the hepatocanalicular bile salt export pump (rodents, Bsep; humans, BSEP ABCB11) could account for bosentan-induced liver injury.	Bosentan	151-159	ATP binding cassette subfamily B member 11	Homo sapiens	120-124
11309550-7	2001	In vitro, Bsep-mediated taurocholate transport was inhibited by bosentan (inhibition constant, approximately 12 micromol/L) and metabolites (inhibition constant, approximately 8.5 micromol/L for metabolite Ro 47-8634).	Taurocholic Acid	24-36	ATP binding cassette subfamily B member 11	Homo sapiens	10-14
11309550-7	2001	In vitro, Bsep-mediated taurocholate transport was inhibited by bosentan (inhibition constant, approximately 12 micromol/L) and metabolites (inhibition constant, approximately 8.5 micromol/L for metabolite Ro 47-8634).	Bosentan	64-72	ATP binding cassette subfamily B member 11	Homo sapiens	10-14
11309550-8	2001	CONCLUSIONS: These results indicate that bosentan-induced liver injury is mediated, at least in part, by inhibition of Bsep/BSEP-causing intracellular accumulation of cytotoxic bile salts and bile salt induced liver cell damage.	Bosentan	41-49	ATP binding cassette subfamily B member 11	Homo sapiens	119-123
11309550-8	2001	CONCLUSIONS: These results indicate that bosentan-induced liver injury is mediated, at least in part, by inhibition of Bsep/BSEP-causing intracellular accumulation of cytotoxic bile salts and bile salt induced liver cell damage.	Bosentan	41-49	ATP binding cassette subfamily B member 11	Homo sapiens	124-128
11309550-8	2001	CONCLUSIONS: These results indicate that bosentan-induced liver injury is mediated, at least in part, by inhibition of Bsep/BSEP-causing intracellular accumulation of cytotoxic bile salts and bile salt induced liver cell damage.	Bile Acids and Salts	177-187	ATP binding cassette subfamily B member 11	Homo sapiens	119-123
11309550-8	2001	CONCLUSIONS: These results indicate that bosentan-induced liver injury is mediated, at least in part, by inhibition of Bsep/BSEP-causing intracellular accumulation of cytotoxic bile salts and bile salt induced liver cell damage.	Bile Acids and Salts	177-186	ATP binding cassette subfamily B member 11	Homo sapiens	119-123
11090958-4	2000	Indeed, biliary elimination of anionic compounds, including glutathione S-conjugates, is mediated by MRP2, whereas bile salts are excreted by a bile salt export pump (BSEP) and Class I-P-glycoprotein (P-gp) is involved in the secretion of amphiphilic cationic drugs, whereas class II-P-gp is a phospholipid transporter.	Bile Acids and Salts	115-125	ATP binding cassette subfamily B member 11	Homo sapiens	144-165
11090958-4	2000	Indeed, biliary elimination of anionic compounds, including glutathione S-conjugates, is mediated by MRP2, whereas bile salts are excreted by a bile salt export pump (BSEP) and Class I-P-glycoprotein (P-gp) is involved in the secretion of amphiphilic cationic drugs, whereas class II-P-gp is a phospholipid transporter.	Bile Acids and Salts	115-125	ATP binding cassette subfamily B member 11	Homo sapiens	167-171
10679031-5	2000	The roles of FIC1 and BSEP in the secretion of bile acids into bile and in the post-secretory modification of bile are under study.	Bile Acids and Salts	47-57	ATP binding cassette subfamily B member 11	Homo sapiens	22-26
10648470-5	2000	RESULTS: Bsep-expressing Sf9 cell vesicles showed ATP-dependent transport of numerous monoanionic bile salts with similar Michaelis constant values as in cLPM vesicles, whereas several known substrates of the multispecific organic anion transporter Mrp2 were not transported by Bsep.	Adenosine Triphosphate	50-53	ATP binding cassette subfamily B member 11	Homo sapiens	9-13
10648470-5	2000	RESULTS: Bsep-expressing Sf9 cell vesicles showed ATP-dependent transport of numerous monoanionic bile salts with similar Michaelis constant values as in cLPM vesicles, whereas several known substrates of the multispecific organic anion transporter Mrp2 were not transported by Bsep.	Adenosine Triphosphate	50-53	ATP binding cassette subfamily B member 11	Homo sapiens	278-282
10648470-5	2000	RESULTS: Bsep-expressing Sf9 cell vesicles showed ATP-dependent transport of numerous monoanionic bile salts with similar Michaelis constant values as in cLPM vesicles, whereas several known substrates of the multispecific organic anion transporter Mrp2 were not transported by Bsep.	Bile Acids and Salts	98-108	ATP binding cassette subfamily B member 11	Homo sapiens	9-13
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	Cyclosporine	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	rifamycin SV	15-27	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	Rifampin	29-39	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	Glyburide	45-58	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	Bile Acids and Salts	87-96	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-6	2000	Cyclosporin A, rifamycin SV, rifampicin, and glibenclamide cis-inhibited Bsep-mediated bile salt transport to similar extents as ATP-dependent taurocholate transport in cLPM vesicles.	Adenosine Triphosphate	129-132	ATP binding cassette subfamily B member 11	Homo sapiens	73-77
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Adenosine Triphosphate	88-91	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Adenosine Triphosphate	88-91	ATP binding cassette subfamily B member 11	Homo sapiens	243-247
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Adenosine Triphosphate	88-91	ATP binding cassette subfamily B member 11	Homo sapiens	243-247
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Taurocholic Acid	102-114	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Taurocholic Acid	102-114	ATP binding cassette subfamily B member 11	Homo sapiens	243-247
10648470-7	2000	In contrast, the cholestatic estrogen metabolite estradiol-17beta-glucuronide inhibited ATP-dependent taurocholate transport only in normal cLPM and in Bsep/Mrp2-coexpressing Sf9 cell vesicles, but not in Mrp2-deficient cLPM or in selectively Bsep-expressing Sf9 cell vesicles, indicating that it trans-inhibits Bsep only after its secretion into bile canaliculi by Mrp2.	Taurocholic Acid	102-114	ATP binding cassette subfamily B member 11	Homo sapiens	243-247
11172067-3	2001	Consistent with in vitro evidence demonstrating the involvement of Spgp in bile salt transport, PFIC2 patients secrete less than 1% of biliary bile salts compared with normal infants.	Bile Acids and Salts	75-84	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
11172067-3	2001	Consistent with in vitro evidence demonstrating the involvement of Spgp in bile salt transport, PFIC2 patients secrete less than 1% of biliary bile salts compared with normal infants.	Bile Acids and Salts	143-153	ATP binding cassette subfamily B member 11	Homo sapiens	96-101
10607905-2	2000	Recently, the rat sister-of-p-glycoprotein/bile salt export pump (spgp/BSEP) was demonstrated to encode for the rat ATP-dependent canalicular bile salt export protein, and mutations of human BSEP were identified as the cause of PFIC 2.	Adenosine Triphosphate	116-119	ATP binding cassette subfamily B member 11	Homo sapiens	228-234
10607905-2	2000	Recently, the rat sister-of-p-glycoprotein/bile salt export pump (spgp/BSEP) was demonstrated to encode for the rat ATP-dependent canalicular bile salt export protein, and mutations of human BSEP were identified as the cause of PFIC 2.	Bile Acids and Salts	43-52	ATP binding cassette subfamily B member 11	Homo sapiens	191-195
10607905-2	2000	Recently, the rat sister-of-p-glycoprotein/bile salt export pump (spgp/BSEP) was demonstrated to encode for the rat ATP-dependent canalicular bile salt export protein, and mutations of human BSEP were identified as the cause of PFIC 2.	Bile Acids and Salts	43-52	ATP binding cassette subfamily B member 11	Homo sapiens	228-234
11076400-1	2000	The bile canaliculus contains at least four ATP-binding cassette (ABC) proteins responsible for ATP-dependent transport of bile acids (spgp), nonbile acid organic anions (mrp2), organic cations (mdr1), and phosphatidylcholine (mdr2).	Bile Acids and Salts	123-133	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
11076400-3	2000	The specific amount and function of spgp and mrp2 in the canalicular membrane increases in response to taurocholate and cAMP.	Taurocholic Acid	103-115	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
11076400-3	2000	The specific amount and function of spgp and mrp2 in the canalicular membrane increases in response to taurocholate and cAMP.	Cyclic AMP	120-124	ATP binding cassette subfamily B member 11	Homo sapiens	36-40
11076396-6	2000	Transport across the canalicular membrane is the rate-limiting step in overall hepatocellular bile salt excretion and is mediated by the bile salt export pump (BSEP), a homologue of the P-glycoproteins or multidrug resistance gene products.	Bile Acids and Salts	94-103	ATP binding cassette subfamily B member 11	Homo sapiens	160-164
11076396-7	2000	BSEP is a vulnerable target for inhibition by estrogen metabolites, drugs such as cyclosporine A, and abnormal bile salt metabolites, all of which can cause retention of bile salts and consequently intrahepatic cholestasis.	Cyclosporine	82-96	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
11076396-7	2000	BSEP is a vulnerable target for inhibition by estrogen metabolites, drugs such as cyclosporine A, and abnormal bile salt metabolites, all of which can cause retention of bile salts and consequently intrahepatic cholestasis.	Bile Acids and Salts	111-120	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
11076396-7	2000	BSEP is a vulnerable target for inhibition by estrogen metabolites, drugs such as cyclosporine A, and abnormal bile salt metabolites, all of which can cause retention of bile salts and consequently intrahepatic cholestasis.	Bile Acids and Salts	170-180	ATP binding cassette subfamily B member 11	Homo sapiens	0-4
11076400-1	2000	The bile canaliculus contains at least four ATP-binding cassette (ABC) proteins responsible for ATP-dependent transport of bile acids (spgp), nonbile acid organic anions (mrp2), organic cations (mdr1), and phosphatidylcholine (mdr2).	Adenosine Triphosphate	44-47	ATP binding cassette subfamily B member 11	Homo sapiens	135-139
9806540-3	1998	The phenotype of the PFIC2-linked group is consistent with defective bile acid transport at the hepatocyte canalicular membrane.	Bile Acids and Salts	69-78	ATP binding cassette subfamily B member 11	Homo sapiens	21-26
10579978-11	1999	Bile salt concentration in bile of BSEP-negative/MRP2-positive PFIC patients was 0.2 +/- 0.2 mmol/L (n = 9; <1% of normal) and in BSEP-positive PFIC patients 18.1 +/- 9.9 mmol/L (n = 3; 40% of normal).	Bile Acids and Salts	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	35-39
10579978-11	1999	Bile salt concentration in bile of BSEP-negative/MRP2-positive PFIC patients was 0.2 +/- 0.2 mmol/L (n = 9; <1% of normal) and in BSEP-positive PFIC patients 18.1 +/- 9.9 mmol/L (n = 3; 40% of normal).	Bile Acids and Salts	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
10579978-12	1999	The kinetic study confirmed the dramatic decrease of bile salt secretion in BSEP-negative patients.	Bile Acids and Salts	53-62	ATP binding cassette subfamily B member 11	Homo sapiens	76-80
10579978-14	1999	Biliary secretion of bile salts is greatly reduced in BSEP-negative patients.	Bile Acids and Salts	21-31	ATP binding cassette subfamily B member 11	Homo sapiens	54-58
10604109-4	1999	The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2.	Bile Acids and Salts	125-135	ATP binding cassette subfamily B member 11	Homo sapiens	62-76
10604109-4	1999	The biochemical and genetic characterization of glycoproteins sP-gp and mdr2-Pgp functioning in the canalicular transport of bile salts and phosphatidylcholine, and the evaluation of their role in experimental and human cholestasis; 2.	Phosphatidylcholines	140-159	ATP binding cassette subfamily B member 11	Homo sapiens	62-76
9545351-0	1998	The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver.	Bile Acids and Salts	56-65	ATP binding cassette subfamily B member 11	Homo sapiens	4-28
9751629-8	1998	The physiological function of Spgp in liver is unknown, but it maps to 2q31 in humans, in the vicinity of liver transport disorders for bile acids and cholesterol.	Bile Acids and Salts	136-146	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
9751629-8	1998	The physiological function of Spgp in liver is unknown, but it maps to 2q31 in humans, in the vicinity of liver transport disorders for bile acids and cholesterol.	Cholesterol	151-162	ATP binding cassette subfamily B member 11	Homo sapiens	30-34
9545351-4	1998	This spgp-mediated taurocholate transport was stimulated solely by ATP, was inhibited by vanadate, and exhibited saturability with increasing concentrations of taurocholate (Km approximately 5 microM).	Taurocholic Acid	19-31	ATP binding cassette subfamily B member 11	Homo sapiens	5-9
9545351-4	1998	This spgp-mediated taurocholate transport was stimulated solely by ATP, was inhibited by vanadate, and exhibited saturability with increasing concentrations of taurocholate (Km approximately 5 microM).	Adenosine Triphosphate	67-70	ATP binding cassette subfamily B member 11	Homo sapiens	5-9
9545351-4	1998	This spgp-mediated taurocholate transport was stimulated solely by ATP, was inhibited by vanadate, and exhibited saturability with increasing concentrations of taurocholate (Km approximately 5 microM).	Vanadates	89-97	ATP binding cassette subfamily B member 11	Homo sapiens	5-9
9545351-4	1998	This spgp-mediated taurocholate transport was stimulated solely by ATP, was inhibited by vanadate, and exhibited saturability with increasing concentrations of taurocholate (Km approximately 5 microM).	Taurocholic Acid	160-172	ATP binding cassette subfamily B member 11	Homo sapiens	5-9
9545351-7	1998	These results indicate that the sister of P-glycoprotein is the major canalicular bile salt export pump of mammalian liver.	Bile Acids and Salts	82-91	ATP binding cassette subfamily B member 11	Homo sapiens	32-56
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Cholesterol	234-245	ATP binding cassette subfamily B member 11	Homo sapiens	174-178
33782042-10	2021	Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters.	Bile Acids and Salts	56-66	ATP binding cassette subfamily B member 11	Homo sapiens	319-323
33782042-10	2021	Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters.	Bile Acids and Salts	56-65	ATP binding cassette subfamily B member 11	Homo sapiens	319-323
33782042-10	2021	Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters.	Bile Acids and Salts	267-276	ATP binding cassette subfamily B member 11	Homo sapiens	319-323
33782042-10	2021	Significance Statement Synthetic modification of common bile acids by attachment of small organic fluorescent dyes to the bile acid side chain resulted in bright, fluorescent probes that interact with hepatic and intestinal organic anion (OATP1B1, OATP1B3, OATP2B1), bile salt uptake (NTCP, ASBT) and bile salt efflux (BSEP, MRP2) transporters.	Bile Acids and Salts	301-310	ATP binding cassette subfamily B member 11	Homo sapiens	319-323
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Bile Acids and Salts	14-24	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Bile Acids and Salts	14-24	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
33782042-2	2021	These bile salts are later secreted into bile across the canalicular membrane, which is facilitated by the bile salt export pump (BSEP).	Bile Acids and Salts	6-16	ATP binding cassette subfamily B member 11	Homo sapiens	107-128
33782042-2	2021	These bile salts are later secreted into bile across the canalicular membrane, which is facilitated by the bile salt export pump (BSEP).	Bile Acids and Salts	6-16	ATP binding cassette subfamily B member 11	Homo sapiens	130-134
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Glutathione	56-67	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Cholesterol	234-245	ATP binding cassette subfamily B member 11	Homo sapiens	179-185
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Glutathione	56-67	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Bile Acids and Salts	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Cholesterol	301-312	ATP binding cassette subfamily B member 11	Homo sapiens	174-178
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Bile Acids and Salts	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Cholesterol	301-312	ATP binding cassette subfamily B member 11	Homo sapiens	179-185
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
33811938-2	2021	The output of bile salts and other organic anions (e.g. glutathione), through the bile salt transporter BSEP/ABCB11 and the organic anion transporter MRP2/ABCC2, respectively, are considered to be the major osmotic driving forces for water secretion into bile canaliculi mainly via aquaporin-8 (AQP8) channels.	Water	234-239	ATP binding cassette subfamily B member 11	Homo sapiens	109-115
32796590-4	2020	The bile salt export pump BSEP as the main motor of bile flow is indirectly involved in bilirubin disposition.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	26-30
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily B member 11	Homo sapiens	174-178
33811938-5	2021	AdhAQP1-transduced hepatocytes show that the canalicularly-expressed hAQP1 not only enhances osmotic membrane water permeability but also induces the transport activities of BSEP/ABCB11 and MRP2/ABCC2 by redistribution in canalicular cholesterol-rich microdomains likely through interactions with the cholesterol-binding protein caveolin-1.	Water	110-115	ATP binding cassette subfamily B member 11	Homo sapiens	179-185
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Glyburide	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	67-88
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Glyburide	0-13	ATP binding cassette subfamily B member 11	Homo sapiens	89-95
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Adenosine Triphosphate	15-18	ATP binding cassette subfamily B member 11	Homo sapiens	67-88
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Adenosine Triphosphate	15-18	ATP binding cassette subfamily B member 11	Homo sapiens	89-95
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Metformin	23-32	ATP binding cassette subfamily B member 11	Homo sapiens	67-88
33763207-0	2020	Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11.	Metformin	23-32	ATP binding cassette subfamily B member 11	Homo sapiens	89-95
33763207-1	2020	Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs.	Bile Acids and Salts	116-126	ATP binding cassette subfamily B member 11	Homo sapiens	12-33
33763207-1	2020	Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs.	Bile Acids and Salts	116-126	ATP binding cassette subfamily B member 11	Homo sapiens	35-39
33763207-1	2020	Background: Bile salt export pump (BSEP/ABCB11) is important in the maintenance of the enterohepatic circulation of bile acids and drugs.	Bile Acids and Salts	116-126	ATP binding cassette subfamily B member 11	Homo sapiens	40-46
33763207-2	2020	Drugs such as rifampicin and glibenclamide inhibit BSEP.	Rifampin	14-24	ATP binding cassette subfamily B member 11	Homo sapiens	51-55
33763207-2	2020	Drugs such as rifampicin and glibenclamide inhibit BSEP.	Glyburide	29-42	ATP binding cassette subfamily B member 11	Homo sapiens	51-55
33763207-16	2020	Western blot and real-time PCR analysis confirmed the upregulation of BSEP on the treatment of HepG2 cells with glibenclamide, ATP, and metformin.	Glyburide	112-125	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
33763207-16	2020	Western blot and real-time PCR analysis confirmed the upregulation of BSEP on the treatment of HepG2 cells with glibenclamide, ATP, and metformin.	Adenosine Triphosphate	127-130	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
33763207-16	2020	Western blot and real-time PCR analysis confirmed the upregulation of BSEP on the treatment of HepG2 cells with glibenclamide, ATP, and metformin.	Metformin	136-145	ATP binding cassette subfamily B member 11	Homo sapiens	70-74
33763207-18	2020	We have found glibenclamide, ATP, and metformin upregulates BSEP.	Glyburide	14-27	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
33763207-18	2020	We have found glibenclamide, ATP, and metformin upregulates BSEP.	Adenosine Triphosphate	29-32	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
33763207-18	2020	We have found glibenclamide, ATP, and metformin upregulates BSEP.	Metformin	38-47	ATP binding cassette subfamily B member 11	Homo sapiens	60-64
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Bile Acids and Salts	33-42	ATP binding cassette subfamily B member 11	Homo sapiens	55-61
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Bile Acids and Salts	33-42	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Methionine	138-148	ATP binding cassette subfamily B member 11	Homo sapiens	55-61
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Methionine	138-148	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Glutamic Acid	175-184	ATP binding cassette subfamily B member 11	Homo sapiens	55-61
33031417-4	2020	In contrast, the closely related bile salt export pump ABCB11 (BSEP), which shares 49% sequence identity with ABCB1, naturally contains a methionine in place of the catalytic glutamate.	Glutamic Acid	175-184	ATP binding cassette subfamily B member 11	Homo sapiens	63-67
32796590-4	2020	The bile salt export pump BSEP as the main motor of bile flow is indirectly involved in bilirubin disposition.	Bilirubin	88-97	ATP binding cassette subfamily B member 11	Homo sapiens	26-30
26507107-4	2016	In this study, the ability of tolvaptan and two metabolites, DM-4103 and DM-4107, to inhibit human hepatic transporters (NTCP, BSEP, MRP2, MRP3, and MRP4) and bile acid transport in sandwich-cultured human hepatocytes (SCHH) was explored.	Tolvaptan	30-39	ATP binding cassette subfamily B member 11	Homo sapiens	127-131
26507107-6	2016	At the therapeutic dose of tolvaptan (90 mg), DM-4103 exhibited a C(max)/IC(50) value &gt;0.1 for NTCP, BSEP, MRP2, MRP3, and MRP4.	UNII-B09E6IIT63	46-53	ATP binding cassette subfamily B member 11	Homo sapiens	104-108
34717914-3	2022	In the present study, we analyzed if the addition of an assay that measures the inhibition of bile acid export carriers, like BSEP and/or MRP2, to the existing method improves the differentiation of hepatotoxic and non-hepatotoxic compounds.	Bile Acids and Salts	94-103	ATP binding cassette subfamily B member 11	Homo sapiens	126-130
23956101-1	2013	The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile acids (BAs) into the bile canaliculi.	Bile Acids and Salts	155-165	ATP binding cassette subfamily B member 11	Homo sapiens	4-25
23956101-1	2013	The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it serves as the primary route of elimination for monovalent bile acids (BAs) into the bile canaliculi.	Bile Acids and Salts	155-165	ATP binding cassette subfamily B member 11	Homo sapiens	27-31
34794962-2	2022	Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI.	Bile Acids and Salts	8-17	ATP binding cassette subfamily B member 11	Homo sapiens	52-73
34794962-2	2022	Altered bile acid homeostasis via inhibition of the bile salt export pump (BSEP) is one mechanism of DILI.	Bile Acids and Salts	8-17	ATP binding cassette subfamily B member 11	Homo sapiens	75-79
34794962-3	2022	Dasatinib, pazopanib and sorafenib are tyrosine kinase inhibitors (TKIs) that competitively inhibit BSEP and increase serum biomarkers for hepatotoxicity in ~25-50% of patients.	Dasatinib	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
34794962-3	2022	Dasatinib, pazopanib and sorafenib are tyrosine kinase inhibitors (TKIs) that competitively inhibit BSEP and increase serum biomarkers for hepatotoxicity in ~25-50% of patients.	pazopanib	11-20	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
34794962-3	2022	Dasatinib, pazopanib and sorafenib are tyrosine kinase inhibitors (TKIs) that competitively inhibit BSEP and increase serum biomarkers for hepatotoxicity in ~25-50% of patients.	Sorafenib	25-34	ATP binding cassette subfamily B member 11	Homo sapiens	100-104
34717914-6	2022	Compared to the CTB cytotoxicity test, substantially lower EC10 values were obtained using the CMFDA assay for several known BSEP and/or MRP2 inhibitors.	5-chloromethylfluorescein	95-100	ATP binding cassette subfamily B member 11	Homo sapiens	125-129
34926449-7	2021	In this study, we demonstrate that arbutin has a protective effect on alpha-naphthylisothiocyanate-induced cholestasis via upregulation of the levels of FXR and downstream enzymes associated with bile acid homeostasis such as Bsep, Ntcp, and Sult2a1, as well as Ugt1a1.	Arbutin	35-42	ATP binding cassette subfamily B member 11	Homo sapiens	226-230
34916690-13	2021	Western blot results indicated that the protein expressions of cleaved caspase-9 and cleaved caspase-3 were upregulated in the HepG2 cell treated with EVO for 48 h. In contrast, the protein expressions of pro-caspase-3, BSEP and MRP2 were downregulated.	evodiamine	151-154	ATP binding cassette subfamily B member 11	Homo sapiens	220-224
34926449-7	2021	In this study, we demonstrate that arbutin has a protective effect on alpha-naphthylisothiocyanate-induced cholestasis via upregulation of the levels of FXR and downstream enzymes associated with bile acid homeostasis such as Bsep, Ntcp, and Sult2a1, as well as Ugt1a1.	Bile Acids and Salts	196-205	ATP binding cassette subfamily B member 11	Homo sapiens	226-230
34483922-4	2021	7-ELCA significantly suppressed the effect of the FXR agonist obeticholic acid in BSEP and SHP regulation in human hepatocytes.	-elca	1-6	ATP binding cassette subfamily B member 11	Homo sapiens	82-86
34964797-5	2021	The bile salt export pump, a transporter protein encoded by the ABCB11 gene, plays the main role in the exportation and accumulation of bile acids.	Bile Acids and Salts	4-13	ATP binding cassette subfamily B member 11	Homo sapiens	64-70
34964797-5	2021	The bile salt export pump, a transporter protein encoded by the ABCB11 gene, plays the main role in the exportation and accumulation of bile acids.	Bile Acids and Salts	136-146	ATP binding cassette subfamily B member 11	Homo sapiens	64-70
34794484-0	2021	In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy.	ivacaftor	30-39	ATP binding cassette subfamily B member 11	Homo sapiens	46-52
34794484-0	2021	In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy.	ivacaftor	30-39	ATP binding cassette subfamily B member 11	Homo sapiens	73-78
34794484-4	2021	RESULTS: The Ala257 residue is located outside the ATP-binding site of ABCB11.	Adenosine Triphosphate	51-54	ATP binding cassette subfamily B member 11	Homo sapiens	71-77
34794484-7	2021	CONCLUSION: Ivacaftor could be considered as a new pharmacological tool able to respond to an unmet medical need for patients with ICP and PFIC2 due to ABCB11 variations affecting ABCB11 function, even when the residue involved is not located in an ATP-binding site of ABCB11.	ivacaftor	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	139-144
34794484-7	2021	CONCLUSION: Ivacaftor could be considered as a new pharmacological tool able to respond to an unmet medical need for patients with ICP and PFIC2 due to ABCB11 variations affecting ABCB11 function, even when the residue involved is not located in an ATP-binding site of ABCB11.	ivacaftor	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	152-158
34794484-7	2021	CONCLUSION: Ivacaftor could be considered as a new pharmacological tool able to respond to an unmet medical need for patients with ICP and PFIC2 due to ABCB11 variations affecting ABCB11 function, even when the residue involved is not located in an ATP-binding site of ABCB11.	ivacaftor	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	180-186
34794484-7	2021	CONCLUSION: Ivacaftor could be considered as a new pharmacological tool able to respond to an unmet medical need for patients with ICP and PFIC2 due to ABCB11 variations affecting ABCB11 function, even when the residue involved is not located in an ATP-binding site of ABCB11.	ivacaftor	12-21	ATP binding cassette subfamily B member 11	Homo sapiens	269-275
34247051-0	2021	Nifuroxazide mitigates cholestatic liver injury by synergistic inhibition of Il-6/Beta-catenin signaling and enhancement of BSEP and MDRP2 expression.	nifuroxazide	0-12	ATP binding cassette subfamily B member 11	Homo sapiens	124-128
34497279-5	2021	Lopinavir and ritonavir in low micromolar concentrations inhibited BSEP and MATE1 exporters, as well as OATP1B1/1B3 uptake transporters.	Lopinavir	0-9	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
34497279-5	2021	Lopinavir and ritonavir in low micromolar concentrations inhibited BSEP and MATE1 exporters, as well as OATP1B1/1B3 uptake transporters.	Ritonavir	14-23	ATP binding cassette subfamily B member 11	Homo sapiens	67-71
34304130-14	2021	Also, YAN ameliorated ethanol-induced cholestasis via inhibiting bile acid uptake transporter Ntcp and inducing bile acid efflux transporter Bsep and Mrp2 expression.	Ethanol	22-29	ATP binding cassette subfamily B member 11	Homo sapiens	141-145
34304130-14	2021	Also, YAN ameliorated ethanol-induced cholestasis via inhibiting bile acid uptake transporter Ntcp and inducing bile acid efflux transporter Bsep and Mrp2 expression.	Bile Acids and Salts	112-121	ATP binding cassette subfamily B member 11	Homo sapiens	141-145
34483922-4	2021	7-ELCA significantly suppressed the effect of the FXR agonist obeticholic acid in BSEP and SHP regulation in human hepatocytes.	obeticholic acid	62-78	ATP binding cassette subfamily B member 11	Homo sapiens	82-86
35523117-0	2022	Alisol B 23-acetate adjusts bile acid metabolisim via hepatic FXR-BSEP signaling activation to alleviate atherosclerosis.	alisol B 23-acetate	0-19	ATP binding cassette subfamily B member 11	Homo sapiens	66-70
35523117-0	2022	Alisol B 23-acetate adjusts bile acid metabolisim via hepatic FXR-BSEP signaling activation to alleviate atherosclerosis.	Bile Acids and Salts	28-37	ATP binding cassette subfamily B member 11	Homo sapiens	66-70
35490150-0	2022	Antisense oligonucleotides rescue an intronic splicing variant in the ABCB11 gene that causes progressive familial intrahepatic cholestasis type 2.	Oligonucleotides	10-26	ATP binding cassette subfamily B member 11	Homo sapiens	70-76
35507739-3	2022	INDIGO was an open-label, Phase 2, international, long-term study to assess the efficacy and safety of maralixibat in children with FIC1 or BSEP deficiencies.	Lopixibat	103-114	ATP binding cassette subfamily B member 11	Homo sapiens	140-144
35507739-9	2022	Serum bile acid (sBA) response (reduction in sBAs of > 75% from baseline or concentrations <102.0 mumol/L) was achieved in 7 patients with nt-BSEP, 6 during once-daily dosing, and 1 after switching to twice-daily dosing.	Bile Acids and Salts	6-15	ATP binding cassette subfamily B member 11	Homo sapiens	142-146
35043010-0	2022	Structures of human bile acid exporter ABCB11 reveal a transport mechanism facilitated by two tandem substrate-binding pockets.	Bile Acids and Salts	20-29	ATP binding cassette subfamily B member 11	Homo sapiens	39-45
35490150-2	2022	We investigated the molecular defect in a PFIC2 infant and rescued the splicing defect with antisense oligonucleotides (ASOs).	Oligonucleotides	102-118	ATP binding cassette subfamily B member 11	Homo sapiens	42-47
35126842-4	2022	LT in PFIC has its own unique issues like high rates of intractable diarrhoea, growth failure; steatohepatitis and graft failure in PFIC1 and antibody-mediated bile salt export pump deficiency in PFIC2.	Bile Acids and Salts	160-169	ATP binding cassette subfamily B member 11	Homo sapiens	196-201
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	27-79
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	81-86
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	143-185
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	192-198
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	217-238
35153175-1	2022	BACKGROUND AND STUDY AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a rare inherited disorder caused by mutation in the ATP-binding cassette subfamily B member 11 gene (ABCB11) that encodes the bile salt export pump (BSEP), which is the main transporter of bile acids from hepatocytes to the canalicular lumen.	Bile Acids and Salts	280-290	ATP binding cassette subfamily B member 11	Homo sapiens	240-244
35153175-2	2022	Defects in BSEP synthesis and/or function lead to reduced bile salt secretion followed by accumulation of bile salts in hepatocytes and hepatocellular damage.	Bile Acids and Salts	58-67	ATP binding cassette subfamily B member 11	Homo sapiens	11-15
35153175-2	2022	Defects in BSEP synthesis and/or function lead to reduced bile salt secretion followed by accumulation of bile salts in hepatocytes and hepatocellular damage.	Bile Acids and Salts	106-116	ATP binding cassette subfamily B member 11	Homo sapiens	11-15
35149083-0	2022	Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression.	Alcohols	0-7	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
35149083-0	2022	Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression.	Bile Acids and Salts	18-27	ATP binding cassette subfamily B member 11	Homo sapiens	58-62
35101544-3	2022	In hBSEP vesicles, eighteen of them were found to have moderate or strong inhibitory effect towards BSEP.	bsep	100-104	ATP binding cassette subfamily B member 11	Homo sapiens	3-8