PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28192990-4	2017	OSamp significantly elevated oxidative stress in cancer cells, leading to enhanced apoptotic cancer cell death through mitochondrial membrane disruption, cytochrome c release, activation of pro-caspase 3, and deactivation of STAT3 (signal transducer and activator of transcription-3).	osamp	0-5	signal transducer and activator of transcription 3	Mus musculus	225-230
28192990-4	2017	OSamp significantly elevated oxidative stress in cancer cells, leading to enhanced apoptotic cancer cell death through mitochondrial membrane disruption, cytochrome c release, activation of pro-caspase 3, and deactivation of STAT3 (signal transducer and activator of transcription-3).	osamp	0-5	signal transducer and activator of transcription 3	Mus musculus	232-282
28383063-0	2017	Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation.	rosmarinic acid	0-15	signal transducer and activator of transcription 3	Mus musculus	131-136
28383063-0	2017	Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation.	dextran sulphate sodium	51-74	signal transducer and activator of transcription 3	Mus musculus	131-136
28383063-0	2017	Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation.	dss	76-79	signal transducer and activator of transcription 3	Mus musculus	131-136
28383063-8	2017	Furthermore, RA effectively and pleiotropically inhibited nuclear factor-kappa B and signal transducer and activator of transcription 3 activation, and subsequently reduced the activity of pro-survival genes that depend on these transcription factors.	rosmarinic acid	13-15	signal transducer and activator of transcription 3	Mus musculus	85-135
28278072-4	2017	Herein, with dextran sulfate sodium (DSS)-induced mouse colitis model, we found that inflammation upregulated key glycolytic enzymes expression via activation of STAT3/c-Myc signaling pathway.	Dextran Sulfate	13-35	signal transducer and activator of transcription 3	Mus musculus	162-167
28278072-4	2017	Herein, with dextran sulfate sodium (DSS)-induced mouse colitis model, we found that inflammation upregulated key glycolytic enzymes expression via activation of STAT3/c-Myc signaling pathway.	Dextran Sulfate	37-40	signal transducer and activator of transcription 3	Mus musculus	162-167
27789465-12	2017	Systemic blockade of IL-6 or STAT-3 can alleviate DMM-induced OA in mice.	dimethylmyleran	50-53	signal transducer and activator of transcription 3	Mus musculus	29-35
27797972-0	2017	Inhibition of STAT3 with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity.	Oligonucleotides	54-69	signal transducer and activator of transcription 3	Mus musculus	14-19
27797972-0	2017	Inhibition of STAT3 with the Generation 2.5 Antisense Oligonucleotide, AZD9150, Decreases Neuroblastoma Tumorigenicity and Increases Chemosensitivity.	danvatirsen	71-78	signal transducer and activator of transcription 3	Mus musculus	14-19
27797972-4	2017	Tet-inducible STAT3 shRNA and AZD9150 decreased cell growth and tumorigenicity.	tet	0-3	signal transducer and activator of transcription 3	Mus musculus	14-19
27797972-5	2017	In vivo, STAT3 inhibition by Tet-inducible STAT3 shRNA or AZD9150 alone had little effect on growth of established tumors.	tet	29-32	signal transducer and activator of transcription 3	Mus musculus	9-14
27797972-5	2017	In vivo, STAT3 inhibition by Tet-inducible STAT3 shRNA or AZD9150 alone had little effect on growth of established tumors.	tet	29-32	signal transducer and activator of transcription 3	Mus musculus	43-48
27797972-5	2017	In vivo, STAT3 inhibition by Tet-inducible STAT3 shRNA or AZD9150 alone had little effect on growth of established tumors.	danvatirsen	58-65	signal transducer and activator of transcription 3	Mus musculus	9-14
27797972-8	2017	Furthermore, inhibition of STAT3 significantly increased neuroblastoma cell sensitivity to cisplatin and decreased tumor growth and increased the survival of tumor-bearing mice in vivoConclusions: Our study supports the development of strategies targeting STAT3 inhibition in combination with conventional chemotherapy for patients with high-risk neuroblastoma.	Cisplatin	91-100	signal transducer and activator of transcription 3	Mus musculus	27-32
28160627-2	2017	While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved to generate a soluble form (sIL-11R) which can elicit trans-signalling.	mil-11r	129-136	signal transducer and activator of transcription 3	Mus musculus	22-27
28160627-2	2017	While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved to generate a soluble form (sIL-11R) which can elicit trans-signalling.	mil-11r	169-176	signal transducer and activator of transcription 3	Mus musculus	22-27
28160627-2	2017	While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membrane-bound IL-11 receptor (mIL-11R), recent evidence suggests that mIL-11R can be proteolytically cleaved to generate a soluble form (sIL-11R) which can elicit trans-signalling.	sil-11r	236-243	signal transducer and activator of transcription 3	Mus musculus	22-27
28242651-0	2017	Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	153-158
28903339-5	2017	PI3K inhibitor ZSTK474 or STAT3 inhibitor Niclosamide not only abolished ING5 knockdown-promoted proliferation, colony formation, migration and invasion of lung cancer A549 cells, but also impaired ING5 knockdown-stimulated metastasis of cancer cells in mouse xenograft models with tail vein injection of A549 cells.	Niclosamide	42-53	signal transducer and activator of transcription 3	Mus musculus	26-31
28170160-5	2017	We showed that upon Doxycycline-mediated activation of the Stat3 short-hairpin RNA, Stat3 expression was efficiently reduced by about 80% in multiple organs and cell types.	Doxycycline	20-31	signal transducer and activator of transcription 3	Mus musculus	59-64
28170160-5	2017	We showed that upon Doxycycline-mediated activation of the Stat3 short-hairpin RNA, Stat3 expression was efficiently reduced by about 80% in multiple organs and cell types.	Doxycycline	20-31	signal transducer and activator of transcription 3	Mus musculus	84-89
28242651-10	2017	These alterations in B and T cell subsets by metformin were associated with enhanced AMPK expression and inhibition of mTOR-STAT3 signaling.	Metformin	45-54	signal transducer and activator of transcription 3	Mus musculus	124-129
28242651-12	2017	Taken together, metformin-induced alterations in AMPK-mTOR-STAT3 signaling may have therapeutic value in SLE by inhibiting B cell differentiation into PCs and GCs.	Metformin	16-25	signal transducer and activator of transcription 3	Mus musculus	59-64
28113104-7	2017	Furthermore, Il-22 and Stat3 mRNA expression in the colon was elevated in WT mice fed with the tryptophan diet, which mainly protected epithelial layer integrity, and Ahr also modulated immune homeostasis by regulating Foxp3 and Il-17 mRNA expression.	Tryptophan	95-105	signal transducer and activator of transcription 3	Mus musculus	23-28
28319809-2	2017	Here, we investigated the effect of activation of STAT3 by cisplatin on anti-apoptotic proteins and the effectiveness of a co-treatment with cisplatin and a BH3 mimetic, ABT-737.	Cisplatin	59-68	signal transducer and activator of transcription 3	Mus musculus	50-55
28319809-3	2017	We analyzed the relationship between cisplatin and STAT3 pathway and effect of ABT-737, when combined with cisplatin in NSCLC cells and K-ras mutant mouse models.	Cisplatin	37-46	signal transducer and activator of transcription 3	Mus musculus	51-56
28319809-6	2017	In NSCLC cells, there was a time and dose-dependent phosphorylation of SRC-JAK2-STAT3 by cisplatin, followed by increased expression of anti-apoptotic molecules.	Cisplatin	89-98	signal transducer and activator of transcription 3	Mus musculus	80-85
28319809-8	2017	Dominant negative STAT3 suppressed their expression, suggesting that STAT3 mediates cisplatin mediated overexpression of the anti-apoptotic molecules.	Cisplatin	84-93	signal transducer and activator of transcription 3	Mus musculus	18-23
28319809-8	2017	Dominant negative STAT3 suppressed their expression, suggesting that STAT3 mediates cisplatin mediated overexpression of the anti-apoptotic molecules.	Cisplatin	84-93	signal transducer and activator of transcription 3	Mus musculus	69-74
28072604-5	2017	In addition, paclitaxel and vincristine both could increase the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the acetylation of histone H4 in the CXCL12-expressing neurons.	Paclitaxel	13-23	signal transducer and activator of transcription 3	Mus musculus	83-133
28903339-6	2017	Furthermore, treatment with ZSTK474 or Niclosamide decreased protein level of EGFR, p-Akt, IL-6 and p-STAT3, and reversed ING5 knockdown-promoted EMT, as indicated by downregulated expression of EMT marker E-cadherin, an epithelial marker, increased expression of N-cadherin, a mesenchymal marker, and EMT-related transcription factors including Snail, Slug, Smad3 and Twist.	ZSTK474	28-35	signal transducer and activator of transcription 3	Mus musculus	102-107
28903339-6	2017	Furthermore, treatment with ZSTK474 or Niclosamide decreased protein level of EGFR, p-Akt, IL-6 and p-STAT3, and reversed ING5 knockdown-promoted EMT, as indicated by downregulated expression of EMT marker E-cadherin, an epithelial marker, increased expression of N-cadherin, a mesenchymal marker, and EMT-related transcription factors including Snail, Slug, Smad3 and Twist.	Niclosamide	39-50	signal transducer and activator of transcription 3	Mus musculus	102-107
29215829-6	2017	It was found that M1-STAT3/6- SMAD3 macrophages have a pronounced anti-tumor effect in vitro, and in vivo, which was greater than anti-tumor effects of M1, M1-STAT 3/6, M1-SMAD3 macrophages and cisplatin.	Cisplatin	194-203	signal transducer and activator of transcription 3	Mus musculus	21-26
28338101-0	2017	The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3.	Valproic Acid	34-47	signal transducer and activator of transcription 3	Mus musculus	121-126
28338101-7	2017	We find that VPA selectively inhibits STAT3 tyrosine705 phosphorylation, but entinostat does not.	tyrosine705	44-55	signal transducer and activator of transcription 3	Mus musculus	38-43
28338101-10	2017	These results show that VPA is a potent inhibitor of STAT3 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylation cooperate in regulating NKG2D expression in NK cells.	Valproic Acid	24-27	signal transducer and activator of transcription 3	Mus musculus	53-58
28338101-10	2017	These results show that VPA is a potent inhibitor of STAT3 phosphorylation and demonstrate that histone acetylation and STAT3 tyrosine705 phosphorylation cooperate in regulating NKG2D expression in NK cells.	tyrosine705	126-137	signal transducer and activator of transcription 3	Mus musculus	120-125
28322331-6	2017	Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment.	Tetradecanoylphorbol Acetate	197-200	signal transducer and activator of transcription 3	Mus musculus	54-59
28386326-9	2017	The LPS-inhibited activation of JAK2/STAT3 and PI3K/Akt was also rescued by Ach, an effect that was blocked by knockdown of the alpha7 nAChR.	Acetylcholine	76-79	signal transducer and activator of transcription 3	Mus musculus	37-42
28386326-10	2017	In contrast, Ach triggered the phosphorylation of JAK2 and STAT3 that was otherwise inactivated by LPS in BV-2 cells.	Acetylcholine	13-16	signal transducer and activator of transcription 3	Mus musculus	59-64
28152548-7	2017	In the largest tumours, only found in mice on high folic acid diet, STAT3 was activated.	Folic Acid	51-61	signal transducer and activator of transcription 3	Mus musculus	68-73
28152548-8	2017	In primary cells from PyMT tumours, STAT3 was activated upon treatment with folic acid in culture.	Folic Acid	76-86	signal transducer and activator of transcription 3	Mus musculus	36-41
26061710-7	2017	Furthermore, pimozide was found to suppress STAT3 activity in HCC cells by attenuating STAT3-dependent luciferase activity and down-regulating the transcription levels of downstream genes of STAT3 signaling.	Pimozide	13-21	signal transducer and activator of transcription 3	Mus musculus	44-49
26061710-7	2017	Furthermore, pimozide was found to suppress STAT3 activity in HCC cells by attenuating STAT3-dependent luciferase activity and down-regulating the transcription levels of downstream genes of STAT3 signaling.	Pimozide	13-21	signal transducer and activator of transcription 3	Mus musculus	87-92
26061710-7	2017	Furthermore, pimozide was found to suppress STAT3 activity in HCC cells by attenuating STAT3-dependent luciferase activity and down-regulating the transcription levels of downstream genes of STAT3 signaling.	Pimozide	13-21	signal transducer and activator of transcription 3	Mus musculus	87-92
27458171-9	2017	Finally, intraperitoneal Capz administration decreased tumor growth in a xenograft mouse prostate cancer model and reduced p-STAT3 and Ki-67 expression.	capsazepine	25-29	signal transducer and activator of transcription 3	Mus musculus	125-130
28072604-5	2017	In addition, paclitaxel and vincristine both could increase the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the acetylation of histone H4 in the CXCL12-expressing neurons.	Paclitaxel	13-23	signal transducer and activator of transcription 3	Mus musculus	135-140
28072604-5	2017	In addition, paclitaxel and vincristine both could increase the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the acetylation of histone H4 in the CXCL12-expressing neurons.	Vincristine	28-39	signal transducer and activator of transcription 3	Mus musculus	83-133
28072604-5	2017	In addition, paclitaxel and vincristine both could increase the phosphorylation of signal transducer and activator of transcription 3 (STAT3) and the acetylation of histone H4 in the CXCL12-expressing neurons.	Vincristine	28-39	signal transducer and activator of transcription 3	Mus musculus	135-140
28273928-0	2017	Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.	lysophosphatidic acid	0-21	signal transducer and activator of transcription 3	Mus musculus	85-90
28273928-0	2017	Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3.	Glucagon	34-42	signal transducer and activator of transcription 3	Mus musculus	85-90
28273928-6	2017	Mechanistically, LPA antagonized glucagon-mediated inhibition of STAT3, a transcriptional repressor of PEPCK.	lysophosphatidic acid	17-20	signal transducer and activator of transcription 3	Mus musculus	65-70
28273928-6	2017	Mechanistically, LPA antagonized glucagon-mediated inhibition of STAT3, a transcriptional repressor of PEPCK.	Glucagon	33-41	signal transducer and activator of transcription 3	Mus musculus	65-70
28273928-8	2017	These data identify a novel role for PLPP1 activity and hepatocyte LPA levels in glucagon sensitivity via a mechanism involving STAT3.	Glucagon	81-89	signal transducer and activator of transcription 3	Mus musculus	128-133
28401002-8	2017	Furthermore, pharmacological inhibition of the activation of the IL-6/STAT3 pathway enhanced hepatic fibrosis and promoted DEN plus CCl4-induced carcinogenesis in Gpr110-/- mice.	Diethylnitrosamine	123-126	signal transducer and activator of transcription 3	Mus musculus	70-75
28401002-8	2017	Furthermore, pharmacological inhibition of the activation of the IL-6/STAT3 pathway enhanced hepatic fibrosis and promoted DEN plus CCl4-induced carcinogenesis in Gpr110-/- mice.	Carbon Tetrachloride	132-136	signal transducer and activator of transcription 3	Mus musculus	70-75
28401024-10	2017	Moreover, treatment of HFD-ThrbPV/PVPten+/- mice with a STAT3 inhibitor, S3I-201, markedly reversed the obesity-induced mammary hyperplasia and reduced EMT signals to lessen cell invasiveness and migration.	thrbpv	27-33	signal transducer and activator of transcription 3	Mus musculus	56-61
28158495-5	2017	The selective STAT-3 inhibitor S3I-201 was administered to fibroblasts in vitro or mice in vivo (10 mg/kg/d, osmotic mini-pump).	NSC 74859	31-38	signal transducer and activator of transcription 3	Mus musculus	14-20
28158495-10	2017	Phosphorylated-STAT3 and collagen upregulation were suppressed by the JAK2 inhibitor AG-490, PDGF receptor inhibitor AG1296 and STAT3-inhibitor SI3-201.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	85-91	signal transducer and activator of transcription 3	Mus musculus	15-20
28158495-10	2017	Phosphorylated-STAT3 and collagen upregulation were suppressed by the JAK2 inhibitor AG-490, PDGF receptor inhibitor AG1296 and STAT3-inhibitor SI3-201.	6,7-dimethoxy-3-phenylquinoxaline	117-123	signal transducer and activator of transcription 3	Mus musculus	15-20
28096316-11	2017	BAY 11-7082 reduced pNF-kappaB, NLRP3, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta expression, blunted the phosphorylation of signal transducer and activators of transcription 3 (STAT3) and decreased IL-23 levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	signal transducer and activator of transcription 3	Mus musculus	156-207
28096316-11	2017	BAY 11-7082 reduced pNF-kappaB, NLRP3, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 and IL-1beta expression, blunted the phosphorylation of signal transducer and activators of transcription 3 (STAT3) and decreased IL-23 levels.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	signal transducer and activator of transcription 3	Mus musculus	209-214
27709605-5	2017	Unlike lipopolysaccharide (LPS), zymosan induced IL-10 and phosphorylated Y705-STAT3 to a similar extent in Irf3 and Ifnar1 knockout and wild-type mice.	Zymosan	33-40	signal transducer and activator of transcription 3	Mus musculus	79-84
27344344-10	2017	Inhibition of p-p65 dependent on PPARalpha activation by PFDA stopped the inflammatory cascade, as indicated by negative response of Il-6, Tnf-alpha, and STAT3 signaling.	perfluorodecanoic acid	57-61	signal transducer and activator of transcription 3	Mus musculus	154-159
27849557-0	2017	Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway.	honokiol	0-8	signal transducer and activator of transcription 3	Mus musculus	68-73
28183999-6	2017	On day 4.5 of pseudopregnancy or in mice treated with progesterone and estrogen to mimic early pregnancy, the estrogen-LIF-ERK and progesterone-IHH pathways remain predominantly intact in GOF beta-catenin mice; however, JAK/STAT signaling is altered.	Progesterone	54-66	signal transducer and activator of transcription 3	Mus musculus	224-228
27903619-0	2017	Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling.	Hyaluronic Acid	91-101	signal transducer and activator of transcription 3	Mus musculus	137-142
27903619-2	2017	Here, we report a novel finding that IL-10 triggers a signal transducer and activator of transcription 3 (STAT3)-dependent signaling pathway that regulates hyaluronan (HA) metabolism and drives adult fibroblasts to synthesize an HA-rich pericellular matrix, which mimics the fetal regenerative wound healing phenotype with reduced fibrosis.	Hyaluronic Acid	156-166	signal transducer and activator of transcription 3	Mus musculus	54-104
27903619-2	2017	Here, we report a novel finding that IL-10 triggers a signal transducer and activator of transcription 3 (STAT3)-dependent signaling pathway that regulates hyaluronan (HA) metabolism and drives adult fibroblasts to synthesize an HA-rich pericellular matrix, which mimics the fetal regenerative wound healing phenotype with reduced fibrosis.	Hyaluronic Acid	156-166	signal transducer and activator of transcription 3	Mus musculus	106-111
27998743-7	2017	Further studies revealed that Amp markedly reduced the phosphorylation levels of JAK2-STAT3 and STAT3 nuclear translocation.	ampelopsin	30-33	signal transducer and activator of transcription 3	Mus musculus	86-91
27998743-7	2017	Further studies revealed that Amp markedly reduced the phosphorylation levels of JAK2-STAT3 and STAT3 nuclear translocation.	ampelopsin	30-33	signal transducer and activator of transcription 3	Mus musculus	96-101
27976373-12	2017	As a result of TAM-induced activation of the STAT3 pathway, 5T33MM cells are sensitized to AZD1480 treatment.	tam	15-18	signal transducer and activator of transcription 3	Mus musculus	45-50
27976373-12	2017	As a result of TAM-induced activation of the STAT3 pathway, 5T33MM cells are sensitized to AZD1480 treatment.	AZD 1480	91-98	signal transducer and activator of transcription 3	Mus musculus	45-50
28274306-8	2017	GA inhibited the protein levels of GATA3, p-JAK3, p-STAT3, p-NF-kappaB, p-IkappaBalpha and increased T-bet protein in MRL/lpr mice.	Glycyrrhizic Acid	0-2	signal transducer and activator of transcription 3	Mus musculus	52-57
28205608-6	2017	Meanwhile, treatment with HC-067047 attenuated the decrease in the activation of reperfusion injury salvage kinase (RISK) pathway (phosphorylation of Akt, ERK1/2, and GSK-3beta), while the activation of survival activating factor enhancement (SAFE) pathway (phosphorylation of STAT3) remained unchanged.	HC-067047	26-35	signal transducer and activator of transcription 3	Mus musculus	277-282
28405527-6	2017	JAK-STAT inhibitor Ruxolitinib selectively inhibits STAT1 and STAT3 activation and increases CTL infiltration to induce a Tc1/Th1 immune response in the tumor microenvironment in an orthotopic pancreatic cancer mouse model.	ruxolitinib	19-30	signal transducer and activator of transcription 3	Mus musculus	62-67
28182002-6	2017	NF-kappaB was shown to be a key mediator for rapamycin, whereas Janus kinase 2, signal transducer and activator of transcription 3, phosphoinositide 3-kinase, and Akt partially mediated rapamycin effects in astrocytes.	Sirolimus	186-195	signal transducer and activator of transcription 3	Mus musculus	80-130
28169326-4	2017	Alanine scanning mutation of Epep revealed residues critical for Tbx3, Klf4 and Esrrb transcript repression, cell-cell contact abrogation, cell survival in suspension, STAT3 phosphorylation and water solubility.	Alanine	0-7	signal transducer and activator of transcription 3	Mus musculus	168-173
28038379-0	2017	High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.	sphingosine 1-phosphate	42-65	signal transducer and activator of transcription 3	Mus musculus	117-122
27978459-0	2017	Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKalpha and downregulation of STAT3 and caspase 3 dependent apoptotic pathways.	Carbon	3-10	signal transducer and activator of transcription 3	Mus musculus	133-138
27717524-0	2017	STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis.	STA-21	0-6	signal transducer and activator of transcription 3	Mus musculus	10-16
27978459-0	2017	Le Carbone, a charcoal supplement, modulates DSS-induced acute colitis in mice through activation of AMPKalpha and downregulation of STAT3 and caspase 3 dependent apoptotic pathways.	Dextran Sulfate	45-48	signal transducer and activator of transcription 3	Mus musculus	133-138
27978459-9	2017	The inflammatory mediators TNFalpha, IL-1beta, p-STAT3 and p-NF-kappaB induced in the colon by DSS were markedly suppressed by LC.	Dextran Sulfate	95-98	signal transducer and activator of transcription 3	Mus musculus	49-54
27717524-1	2017	We set out to investigate the influence of STA-21, a dynamic STAT-3 inhibitor, on the expansion and progression of rheumatoid arthritis (RA), and to determine its potential mechanisms of action in a mouse model of collagen antibody-induced arthritis (CAIA).	STA-21	43-49	signal transducer and activator of transcription 3	Mus musculus	61-67
27717524-8	2017	Thus, administration of the Stat3 inhibitor STA-21 inhibits cellular signaling pathways and downstream activation of key transcription factors previously shown to play key roles in the pathogenesis of RA.	STA-21	44-50	signal transducer and activator of transcription 3	Mus musculus	28-33
27835873-6	2017	6-OAP inhibited tumor growth in SCID mice intravenously injected with lung cancer cells, and downregulated both STAT3 and Skp2 in tumor samples.	6-O-angeloylprenolin	0-5	signal transducer and activator of transcription 3	Mus musculus	112-117
28122601-12	2017	CONCLUSIONS: The loss of muscle mass in slow muscles in the absence of vitamin D signaling is due to elevated levels of phosphorylated Stat3 that leads to an increase in Myostatin signaling, which in turn decreases protein synthesis and fiber size through the phosphorylation of p70S6K and rpS6, respectively.	Vitamin D	71-80	signal transducer and activator of transcription 3	Mus musculus	135-140
28086773-1	2017	Karun & Hyde), the giant oyster mushroom inhibits NO production in LPS/H2O2 stimulated RAW 264.7 cells via STAT 3 and COX-2 pathways.	Hydrogen Peroxide	75-79	signal transducer and activator of transcription 3	Mus musculus	111-117
28065589-6	2017	Knockdown of PERK attenuated TG-induced CXCL10 and CCL2 mRNA expression, associated with significant decreases in phosphorylation of NF-kappaB RelA and STAT3.	Thapsigargin	29-31	signal transducer and activator of transcription 3	Mus musculus	152-157
28065589-8	2017	Blockade of NF-kappaB or STAT3 markedly diminished TG-induced CXCL10 and CCL2 expression.	Thapsigargin	51-53	signal transducer and activator of transcription 3	Mus musculus	25-30
27709266-11	2017	The protective effect of nicotine in murine DSS colitis depends on blocking STAT3 activation.	Nicotine	25-33	signal transducer and activator of transcription 3	Mus musculus	76-81
27984001-10	2017	Topical application of STA-21, a small molecule STAT3 inhibitor significantly reduced airway inflammation in allergic mice having psoriatic inflammation.	STA-21	23-29	signal transducer and activator of transcription 3	Mus musculus	48-53
27292260-6	2017	Treatment with HO-3867 (a novel STAT3 inhibitor at 100 p.p.m.	(3,5-bis((4-fluorophenyl)methylidene)-1-((1-hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl)piperidin-4-one)	15-22	signal transducer and activator of transcription 3	Mus musculus	32-37
27901267-9	2017	Similarly, the combination of alcohol and hypergravity suppressed the levels of STAT3, FOXO1/3, C/EBPbeta, and CREB, transcription factors necessary for cell survival.	Alcohols	30-37	signal transducer and activator of transcription 3	Mus musculus	80-85
28085115-0	2017	Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	80-85
28085115-9	2017	Icaritin significantly inhibited the expression of phospho-STAT3 (p-STAT3) in a dose- and time-dependent manner.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	59-64
28085115-9	2017	Icaritin significantly inhibited the expression of phospho-STAT3 (p-STAT3) in a dose- and time-dependent manner.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	68-73
28085115-11	2017	Overall, icaritin suppressed proliferation, promoted apoptosis and autophagy, and inhibited STAT3 signaling in OSCC in vitro and in vivo.	icaritin	9-17	signal transducer and activator of transcription 3	Mus musculus	92-97
27568040-3	2017	Upregulation of bile acid biosynthesis genes and downregulation of epidermal growth factor receptor (EGFR) expression were observed in STAT3 hc Mdr2-/- mice but the functional consequences of these processes in cholestatic liver injury remained unclear.	Bile Acids and Salts	16-25	signal transducer and activator of transcription 3	Mus musculus	135-140
27524110-7	2017	During dextran sulfate sodium-induced colitis, a dysfunctional IL-18/IL-22BP pathway in Aim2-/- mice promotes excessive IL-22 production and elevated STAT3 activation.	Dextran Sulfate	7-29	signal transducer and activator of transcription 3	Mus musculus	150-155
28977786-9	2017	Interestingly, pretreatment with the JAK/STAT3 inhibitor AG490 blocked the cardioprotective effect of RIPostC accompanied by decreased phosphorylation of myocardial STAT3, Akt and eNOS (P < 0.05), decreased nuclear translocation of Nrf2 and expression of HO-1, as well as increased oxidative stress (P < 0.05).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	57-62	signal transducer and activator of transcription 3	Mus musculus	41-46
28977786-9	2017	Interestingly, pretreatment with the JAK/STAT3 inhibitor AG490 blocked the cardioprotective effect of RIPostC accompanied by decreased phosphorylation of myocardial STAT3, Akt and eNOS (P < 0.05), decreased nuclear translocation of Nrf2 and expression of HO-1, as well as increased oxidative stress (P < 0.05).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	57-62	signal transducer and activator of transcription 3	Mus musculus	165-170
28977786-9	2017	Interestingly, pretreatment with the JAK/STAT3 inhibitor AG490 blocked the cardioprotective effect of RIPostC accompanied by decreased phosphorylation of myocardial STAT3, Akt and eNOS (P < 0.05), decreased nuclear translocation of Nrf2 and expression of HO-1, as well as increased oxidative stress (P < 0.05).	ripostc	102-109	signal transducer and activator of transcription 3	Mus musculus	41-46
28977786-9	2017	Interestingly, pretreatment with the JAK/STAT3 inhibitor AG490 blocked the cardioprotective effect of RIPostC accompanied by decreased phosphorylation of myocardial STAT3, Akt and eNOS (P < 0.05), decreased nuclear translocation of Nrf2 and expression of HO-1, as well as increased oxidative stress (P < 0.05).	ripostc	102-109	signal transducer and activator of transcription 3	Mus musculus	165-170
28798799-5	2017	Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression.	1-Deoxynojirimycin	68-71	signal transducer and activator of transcription 3	Mus musculus	225-230
27778412-8	2017	However, the increased IL-6 was blocked by pre-treatment of MLO-Y4 cells with the ERK1/2 inhibitor U0126 (10 microM), and the enhanced RANKL was blocked by the STAT3 inhibitor S3I-201 (100 microM).	NSC 74859	176-183	signal transducer and activator of transcription 3	Mus musculus	160-165
29216639-9	2017	Finally, we found that Exendin-4 induced macrophage polarization via the cAMP-PKA-STAT3 signaling pathway.	Cyclic AMP	73-77	signal transducer and activator of transcription 3	Mus musculus	82-87
27810232-0	2017	Potential role of IL-17-producing CD4/CD8 double negative alphabeta T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model.	Tetradecanoylphorbol Acetate	112-115	signal transducer and activator of transcription 3	Mus musculus	124-129
27568040-4	2017	Here, we show normal canalicular architecture and bile flow but increased amounts of bile acids in the bile of STAT3 hc Mdr2-/- mice.	Bile Acids and Salts	85-95	signal transducer and activator of transcription 3	Mus musculus	111-116
27568040-5	2017	Moreover, STAT3-deficient hepatocytes displayed increased sensitivity to bile acid-induced apoptosis in vitro.	Bile Acids and Salts	73-82	signal transducer and activator of transcription 3	Mus musculus	10-15
27568040-9	2017	KEY MESSAGE: STAT3 is a negative regulator of bile acid biosynthesis.	Bile Acids and Salts	46-55	signal transducer and activator of transcription 3	Mus musculus	13-18
27568040-10	2017	STAT3 protects from bile acid-induced apoptosis and regulates EGFR expression.	Bile Acids and Salts	20-29	signal transducer and activator of transcription 3	Mus musculus	0-5
27696512-10	2017	Following DEN treatment, mice exhibited increased phosphorylation of PI3K, AKT, mTOR, STAT3, ERK, and p38, and a higher expression of NF-kappaB p50 and p65 subunits.	Diethylnitrosamine	10-13	signal transducer and activator of transcription 3	Mus musculus	86-91
28004106-4	2017	Resveratrol downregulated the expression of inflammatory markers, such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, induced by LPS, and inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) and signal transducer and activator of transcription (STAT)1/STAT3.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	288-293
28626343-8	2017	In addition, the signal transducer and activator of transcription (STAT) 1 and STAT3 signaling was activated by tyrosine phosphorylation in LN mouse renal tissue, indicating that the phosphorylated STAT1 (p-STAT1) and p-STAT3 were involved in kidney injury.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	79-84
28626343-8	2017	In addition, the signal transducer and activator of transcription (STAT) 1 and STAT3 signaling was activated by tyrosine phosphorylation in LN mouse renal tissue, indicating that the phosphorylated STAT1 (p-STAT1) and p-STAT3 were involved in kidney injury.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	220-225
28626343-10	2017	Thus, we concluded that OSM is associated with TIL in lupus nephritis, which may be connected with the activation of STAT3 rather than that of STAT1.	TIL	47-50	signal transducer and activator of transcription 3	Mus musculus	117-122
29358851-8	2017	Anti-IL-22 nAb significantly alleviated the severity of hypertrophy, prevented systolic and diastolic abnormalities, reduced cardiac fibrosis, STAT3 and ERK phosphorylation, and downregulated the mRNA expression of IL-17, IL-6, IL-1beta, IFN-gamma, and TNF-alpha.	nab	11-14	signal transducer and activator of transcription 3	Mus musculus	143-148
26894620-8	2017	IL10 expression, an anti-inflammatory mediator, and downstream signaling events (Stat3) were significantly increased in the Ereg-/- mice in response to BHT, supporting both reduced inflammation and tumorigenesis.	Butylated Hydroxytoluene	152-155	signal transducer and activator of transcription 3	Mus musculus	81-86
29166835-4	2017	We also found that the signal transducers and transcription activator 3 (STAT3) was activated in the dorsal root ganglion, and inhibition of STAT3 with S3I-201 or the injection of AAV-Cre-GFP into STAT3flox/flox mice prevented the upregulation of CXCL12 expression in the dorsal root ganglion and chronic pain following oxaliplatin administration.	Oxaliplatin	320-331	signal transducer and activator of transcription 3	Mus musculus	23-71
29166835-4	2017	We also found that the signal transducers and transcription activator 3 (STAT3) was activated in the dorsal root ganglion, and inhibition of STAT3 with S3I-201 or the injection of AAV-Cre-GFP into STAT3flox/flox mice prevented the upregulation of CXCL12 expression in the dorsal root ganglion and chronic pain following oxaliplatin administration.	Oxaliplatin	320-331	signal transducer and activator of transcription 3	Mus musculus	73-78
29166835-4	2017	We also found that the signal transducers and transcription activator 3 (STAT3) was activated in the dorsal root ganglion, and inhibition of STAT3 with S3I-201 or the injection of AAV-Cre-GFP into STAT3flox/flox mice prevented the upregulation of CXCL12 expression in the dorsal root ganglion and chronic pain following oxaliplatin administration.	Oxaliplatin	320-331	signal transducer and activator of transcription 3	Mus musculus	141-146
29166835-4	2017	We also found that the signal transducers and transcription activator 3 (STAT3) was activated in the dorsal root ganglion, and inhibition of STAT3 with S3I-201 or the injection of AAV-Cre-GFP into STAT3flox/flox mice prevented the upregulation of CXCL12 expression in the dorsal root ganglion and chronic pain following oxaliplatin administration.	Oxaliplatin	320-331	signal transducer and activator of transcription 3	Mus musculus	141-146
28819544-4	2017	Cultivation in 1% O2 for 24 h resulted in the strong dephosphorylation of ERK and its upstream kinases and to a lesser extent of Akt in an HIF-1-independent manner, while STAT3 phosphorylation remained unaffected.	Oxygen	18-20	signal transducer and activator of transcription 3	Mus musculus	171-176
27676194-0	2017	Folic Acid Supports Pluripotency and Reprogramming by Regulating LIF/STAT3 and MAPK/ERK Signaling.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	69-74
28066259-0	2016	IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells.	Glucose	60-67	signal transducer and activator of transcription 3	Mus musculus	25-30
28066259-12	2016	We have evidence that a mediator of glucose uptake, HIF1alpha, expression was dependent on IL-15 induced STAT3 activation.	Glucose	36-43	signal transducer and activator of transcription 3	Mus musculus	105-110
28066259-13	2016	Finally, upon inhibition of STAT3 the positive effects of IL-15 on glucose uptake and GLUT4 translocation were abolished.	Glucose	67-74	signal transducer and activator of transcription 3	Mus musculus	28-33
27977755-11	2016	In conclusion, taxifolin and cilostazol strongly inhibited amyloidogenesis in a synergistic manner by suppressing P-JAK2/P-STAT3-coupled NF-kappaB-linked BACE1 expression via the up-regulation of SIRT1.	taxifolin	15-24	signal transducer and activator of transcription 3	Mus musculus	123-128
27978873-16	2016	Gefitinib can be used to effectively treat NSCLC, and the mechanism may be associated with an increased level of STAT3 phosphorylation.	Gefitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	113-118
27999284-0	2016	Aspirin down Regulates Hepcidin by Inhibiting NF-kappaB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide.	Aspirin	0-7	signal transducer and activator of transcription 3	Mus musculus	69-74
27999284-4	2016	We demonstrated that aspirin inhibited hepcidin mRNA as well as NO production in cells treated with LPS, but not in cells without LPS, suppresses IL-6, JAK2, STAT3, and P65 (nuclear factor-kappaB) phosphorylation and has no effect on IRP1 in cells treated with or without LPS.	Aspirin	21-28	signal transducer and activator of transcription 3	Mus musculus	158-163
27999284-5	2016	These findings provide evidence that aspirin down regulates hepcidin by inhibiting IL6/JAK2/STAT3 and P65 (nuclear factor-kappaB) pathways in the cells under inflammatory conditions, and imply that an aspirin-induced reduction in TfR1 and an increase in ferritin are not associated with IRP1 and NO.	Aspirin	37-44	signal transducer and activator of transcription 3	Mus musculus	92-97
27977755-11	2016	In conclusion, taxifolin and cilostazol strongly inhibited amyloidogenesis in a synergistic manner by suppressing P-JAK2/P-STAT3-coupled NF-kappaB-linked BACE1 expression via the up-regulation of SIRT1.	Cilostazol	29-39	signal transducer and activator of transcription 3	Mus musculus	123-128
27941940-9	2016	Furthermore, kefir peptides activated JAK2 to stimulate STAT3 phosphorylation, which can translocate to the nucleus, and upregulated several genes, including the CPT1 (carnitine palmitoyltransferase-1) involved in fatty acid oxidation.	Fatty Acids	214-224	signal transducer and activator of transcription 3	Mus musculus	56-61
27941940-10	2016	CONCLUSION: Our data have demonstrated that kefir peptides can improve the symptoms of NAFLD, including body weight, energy intake, inflammatory reaction and the formation of fatty liver by activating JAK2 signal transduction through the JAK2/STAT3 and JAK2/AMPK pathways in the high-fructose-induced fatty liver animal model.	Fructose	284-292	signal transducer and activator of transcription 3	Mus musculus	243-248
27225906-3	2016	We sought to determine whether C188-9, a small-molecule STAT3 inhibitor, can block Th2 and Th17 cell expansion and cytokine production to prevent house dust mite (HDM)-induced airway inflammation and remodeling.	C188-9	31-37	signal transducer and activator of transcription 3	Mus musculus	56-61
27485250-4	2016	Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland.	Corticosterone	0-14	signal transducer and activator of transcription 3	Mus musculus	160-165
28101184-3	2016	Flavonoid luteolin has been shown to markedly inhibit Tyr705 activation/phosphorylation of STAT3 and exert anti-inflammatory effects in multiple sclerosis.	Flavonoids	0-9	signal transducer and activator of transcription 3	Mus musculus	91-96
27282405-6	2016	During lipid accumulation in hepatocytes, both fat and alcohol induced the recruitment of PI3K or Socs3 by Gab2 and the activation of their downstream signaling proteins AKT, ERK, and Stat3.	Alcohols	55-62	signal transducer and activator of transcription 3	Mus musculus	184-189
27899891-9	2016	Rates of glucose oxidation were similar between hearts of WT plus saline and CTRL plus ANG II mice; however, glucose oxidation was increased by 66% in hearts of ANG II-treated STAT3 KO mice.	Glucose	109-116	signal transducer and activator of transcription 3	Mus musculus	176-181
26666668-12	2016	Real-time PCR and Western blotting revealed that Corilagin downregulated the expression of TNF-alpha and IL-1beta and inhibited the irradiation-induced activation of NF-kappaB pathways by upregulating p-STAT3 expression.	corilagin	49-58	signal transducer and activator of transcription 3	Mus musculus	203-208
26666668-14	2016	Corilagin might inhibit the activation of NF-kappaB pathway in a STAT3-associated manner, thereby downregulating the inflammatory cytokine expressions.	corilagin	0-9	signal transducer and activator of transcription 3	Mus musculus	65-70
27779705-0	2016	Diphenhydramine induces melanoma cell apoptosis by suppressing STAT3/MCL-1 survival signaling and retards B16-F10 melanoma growth in vivo.	Diphenhydramine	0-15	signal transducer and activator of transcription 3	Mus musculus	63-68
27779705-7	2016	Moreover, DPH attenuated STAT3 activation, as evidenced by the reduced levels of tyrosine 705-phosphorylated STAT3.	Diphenhydramine	10-13	signal transducer and activator of transcription 3	Mus musculus	25-30
27779705-7	2016	Moreover, DPH attenuated STAT3 activation, as evidenced by the reduced levels of tyrosine 705-phosphorylated STAT3.	Diphenhydramine	10-13	signal transducer and activator of transcription 3	Mus musculus	109-114
27779705-7	2016	Moreover, DPH attenuated STAT3 activation, as evidenced by the reduced levels of tyrosine 705-phosphorylated STAT3.	Tyrosine	81-89	signal transducer and activator of transcription 3	Mus musculus	25-30
27779705-7	2016	Moreover, DPH attenuated STAT3 activation, as evidenced by the reduced levels of tyrosine 705-phosphorylated STAT3.	Tyrosine	81-89	signal transducer and activator of transcription 3	Mus musculus	109-114
27779705-8	2016	Notably, ectopic expression of constitutively active STAT3 mutant reduced DPH-induced apoptosis but also protected MCL-1 from downregulation by DPH, illustrating that DPH impairs STAT3 activation to block STAT3-mediated induction of MCL-1 in eliciting apoptosis.	Diphenhydramine	74-77	signal transducer and activator of transcription 3	Mus musculus	53-58
27779705-8	2016	Notably, ectopic expression of constitutively active STAT3 mutant reduced DPH-induced apoptosis but also protected MCL-1 from downregulation by DPH, illustrating that DPH impairs STAT3 activation to block STAT3-mediated induction of MCL-1 in eliciting apoptosis.	Diphenhydramine	144-147	signal transducer and activator of transcription 3	Mus musculus	53-58
27779705-8	2016	Notably, ectopic expression of constitutively active STAT3 mutant reduced DPH-induced apoptosis but also protected MCL-1 from downregulation by DPH, illustrating that DPH impairs STAT3 activation to block STAT3-mediated induction of MCL-1 in eliciting apoptosis.	Diphenhydramine	144-147	signal transducer and activator of transcription 3	Mus musculus	53-58
27779705-9	2016	Collectively, we for the first time validate the in vivo anti-melanoma effect of DPH and also establish DPH as a drug targeting STAT3/MCL-1 survival signaling pathway to induce apoptosis.	Diphenhydramine	104-107	signal transducer and activator of transcription 3	Mus musculus	128-133
27875549-0	2016	The Synthetic beta-Nitrostyrene Derivative CYT-Rx20 Inhibits Esophageal Tumor Growth and Metastasis via PI3K/AKT and STAT3 Pathways.	beta-nitrostyrene	14-31	signal transducer and activator of transcription 3	Mus musculus	117-122
27845373-6	2016	We showed that MMPP strongly inhibited pro-inflammatory responses by inhibiting in vitro STAT3 activation and its downstream signalling in murine macrophages and human synoviocytes from patients with RA.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	15-19	signal transducer and activator of transcription 3	Mus musculus	89-94
27634873-0	2016	Piperlongumine induces apoptosis and reduces bortezomib resistance by inhibiting STAT3 in multiple myeloma cells.	piperlonguminine	0-14	signal transducer and activator of transcription 3	Mus musculus	81-86
27634873-6	2016	Mechanistically, piperlongumine inhibited the STAT3 signal pathway in MM cells by binding directly to the STAT3 Cys712 residue.	piperlonguminine	17-31	signal transducer and activator of transcription 3	Mus musculus	46-51
27634873-6	2016	Mechanistically, piperlongumine inhibited the STAT3 signal pathway in MM cells by binding directly to the STAT3 Cys712 residue.	piperlonguminine	17-31	signal transducer and activator of transcription 3	Mus musculus	106-111
27697726-6	2016	PAG also inhibited the expression and phosphorylation of signal transducer and activator of transcription 3, which is known to connect inflammation and cancer.	pag	0-3	signal transducer and activator of transcription 3	Mus musculus	57-107
30108694-9	2017	Canertinib exposure of Tu-2449 cells rapidly caused the inhibition of the Bmx kinase and the deactivation of Stat3.	Canertinib	0-10	signal transducer and activator of transcription 3	Mus musculus	109-114
30108694-9	2017	Canertinib exposure of Tu-2449 cells rapidly caused the inhibition of the Bmx kinase and the deactivation of Stat3.	Thiourea	23-25	signal transducer and activator of transcription 3	Mus musculus	109-114
30108694-15	2017	We suggest that Stat3 induction through tight cell-cell interactions, most likely through the engagement of cadherins, can counteract the inhibitory effects exerted by canertinib on Bmx.	Canertinib	168-178	signal transducer and activator of transcription 3	Mus musculus	16-21
30108694-16	2017	Cell-cell interactions induced Stat3 and compensated for the suppression of Stat3 by canertinib, thus transiently protecting the cells from the cytotoxic effects of the inhibitor.	Canertinib	85-95	signal transducer and activator of transcription 3	Mus musculus	31-36
30108694-16	2017	Cell-cell interactions induced Stat3 and compensated for the suppression of Stat3 by canertinib, thus transiently protecting the cells from the cytotoxic effects of the inhibitor.	Canertinib	85-95	signal transducer and activator of transcription 3	Mus musculus	76-81
27724964-0	2016	Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice.	sinomenine	0-10	signal transducer and activator of transcription 3	Mus musculus	108-113
27713471-6	2016	This was attributed to: (i) activation of STAT3 in STAT5-deficient mice, which was prevented by JAK2 deficiency and (ii) increased detoxification capacity of JAK2-deficient livers, which diminished oxidative damage as compared to GHtgSTAT5Deltahep mice, despite equally severe steatosis and reactive oxygen species (ROS) production.	Reactive Oxygen Species	291-314	signal transducer and activator of transcription 3	Mus musculus	42-47
27713471-6	2016	This was attributed to: (i) activation of STAT3 in STAT5-deficient mice, which was prevented by JAK2 deficiency and (ii) increased detoxification capacity of JAK2-deficient livers, which diminished oxidative damage as compared to GHtgSTAT5Deltahep mice, despite equally severe steatosis and reactive oxygen species (ROS) production.	Reactive Oxygen Species	316-319	signal transducer and activator of transcription 3	Mus musculus	42-47
27706259-5	2016	Gh-induced Stat3 phosphorylation is known to be a mechanism of Gh oversecretion in GH3.	3'-dGTP	83-86	signal transducer and activator of transcription 3	Mus musculus	11-16
27535961-5	2016	When the recipient mice were treated with niclosamide for 3 weeks, niclosamide reduced the size of endometriotic implants with inhibition of cell proliferation, and inflammatory signaling including RELA (NFKB) and STAT3 activation, but did not alter expression of steroid hormone receptors.	Niclosamide	42-53	signal transducer and activator of transcription 3	Mus musculus	214-219
27768775-0	2016	Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice.	Dexmedetomidine	0-15	signal transducer and activator of transcription 3	Mus musculus	34-39
27768775-0	2016	Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice.	Isoflurane	61-71	signal transducer and activator of transcription 3	Mus musculus	34-39
27768775-14	2016	Increased phosphorylation of JAK2 and STAT3 in the hippocampus induced by isoflurane was augmented by dexmedetomidine.	Isoflurane	74-84	signal transducer and activator of transcription 3	Mus musculus	38-43
27768775-14	2016	Increased phosphorylation of JAK2 and STAT3 in the hippocampus induced by isoflurane was augmented by dexmedetomidine.	Dexmedetomidine	102-117	signal transducer and activator of transcription 3	Mus musculus	38-43
27768775-15	2016	Effects of dexmedetomidine on JAK2/STAT3 phosphorylation were attenuated by atipamezole, AG490 and WP1066.	Dexmedetomidine	11-26	signal transducer and activator of transcription 3	Mus musculus	35-40
27768775-15	2016	Effects of dexmedetomidine on JAK2/STAT3 phosphorylation were attenuated by atipamezole, AG490 and WP1066.	atipamezole	76-87	signal transducer and activator of transcription 3	Mus musculus	35-40
27768775-18	2016	CONCLUSION: Dexmedetomidine could protect against isoflurane-induced spatial learning and memory impairment in senile mice by stimulating the JAK2/STAT3 signaling pathway.	Dexmedetomidine	12-27	signal transducer and activator of transcription 3	Mus musculus	147-152
27768775-18	2016	CONCLUSION: Dexmedetomidine could protect against isoflurane-induced spatial learning and memory impairment in senile mice by stimulating the JAK2/STAT3 signaling pathway.	Isoflurane	50-60	signal transducer and activator of transcription 3	Mus musculus	147-152
27535961-5	2016	When the recipient mice were treated with niclosamide for 3 weeks, niclosamide reduced the size of endometriotic implants with inhibition of cell proliferation, and inflammatory signaling including RELA (NFKB) and STAT3 activation, but did not alter expression of steroid hormone receptors.	Niclosamide	67-78	signal transducer and activator of transcription 3	Mus musculus	214-219
27318964-7	2016	In vitro studies in B16F10 murine melanoma cells showed that AuNP-CS/siRNA/CS inhibited the cell growth by 49.0+-0.6% and 66.0+-0.2% at 0.25nM and 0.5nM STAT3 siRNA concentration, respectively.	aunp-cs	61-68	signal transducer and activator of transcription 3	Mus musculus	153-158
27522260-6	2016	Moreover, astilbin inhibited activation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) cascade and over-expression of suppressor of cytokine signaling 3 (SOCS3) in the kidneys of potassium oxonate-induced mice.	astilbin	10-18	signal transducer and activator of transcription 3	Mus musculus	119-124
27318964-7	2016	In vitro studies in B16F10 murine melanoma cells showed that AuNP-CS/siRNA/CS inhibited the cell growth by 49.0+-0.6% and 66.0+-0.2% at 0.25nM and 0.5nM STAT3 siRNA concentration, respectively.	Cesium	66-68	signal transducer and activator of transcription 3	Mus musculus	153-158
27318964-13	2016	In conclusion, layer-by-layer chitosan coated AuNP can be developed as a carrier for iontophoretic delivery of STAT3 siRNA to treat melanoma.	Chitosan	30-38	signal transducer and activator of transcription 3	Mus musculus	111-116
27318964-13	2016	In conclusion, layer-by-layer chitosan coated AuNP can be developed as a carrier for iontophoretic delivery of STAT3 siRNA to treat melanoma.	aunp	46-50	signal transducer and activator of transcription 3	Mus musculus	111-116
27546300-4	2016	Ruxolitinib pre-treatments also curbed TAA-induced rise in NF-kappaB nuclear expression and STAT3 phosphorylation.	ruxolitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	92-97
27546461-0	2016	Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis.	Iron	0-4	signal transducer and activator of transcription 3	Mus musculus	52-57
27546461-4	2016	Proteomic and genomic analyses identified an iron-regulated signaling axis mediated by cyclin-dependent kinase 1 (CDK1), JAK1, and STAT3 in CRC progression.	Iron	45-49	signal transducer and activator of transcription 3	Mus musculus	131-136
27317636-7	2016	Additionally, we demonstrated that HS induced autophagy, including increased LC3B and Beclin-1 expression and decreased phosphorylation of mTOR and Stat3, as well as phosphorylation of ERK.	hassio	35-37	signal transducer and activator of transcription 3	Mus musculus	148-153
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	0-27	signal transducer and activator of transcription 3	Mus musculus	125-130
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	pyrrolidine dithiocarbamic acid	29-33	signal transducer and activator of transcription 3	Mus musculus	125-130
27458163-2	2016	Here, we showed that honokiol (2.5-7.5 muM), a bioactive compound of Magnolia officinalis, differentially suppressed proliferation (up to 93%) and induced apoptosis (up to 61%) of EGFR overexpressing tumorigenic bronchial cells and these effects were paralleled by downregulation of phospho-EGFR, phospho-Akt, phospho-STAT3 and cell cycle-related proteins as early as 6-12 h post-treatment.	honokiol	21-29	signal transducer and activator of transcription 3	Mus musculus	318-323
27458163-7	2016	Furthermore, in a mouse lung tumor bioassay, intranasal instillation of liposomal honokiol (5 mg/kg) for 14 weeks reduced the size and multiplicity (49%) of lung tumors and the level of total- and phospho-EGFR, phospho-Akt and phospho-STAT3.	honokiol	82-90	signal transducer and activator of transcription 3	Mus musculus	235-240
27215660-14	2016	This process involves activation of YAP1 and TAZ in acinar cells, which up-regulate JAK-STAT3 signaling to promote development of PDAC in mice.	pdac	130-134	signal transducer and activator of transcription 3	Mus musculus	88-93
27236299-0	2016	Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze.	peoniflorin	0-12	signal transducer and activator of transcription 3	Mus musculus	29-34
27236299-0	2016	Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze.	1-chloro-2,4-dinitrobenze	103-128	signal transducer and activator of transcription 3	Mus musculus	29-34
27236299-5	2016	In this study, we show clearly that PF markedly decreases IL-6/Stat3 in DCs stimulated with DNCB at both gene and protein levels compared with control DCs in vitro.	Dinitrochlorobenzene	92-96	signal transducer and activator of transcription 3	Mus musculus	63-68
27240136-0	2016	Isocyperol, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced inflammatory responses via suppression of the NF-kappaB and STAT3 pathways and ROS stress in LPS-stimulated RAW 264.7 cells.	isocyperol	0-10	signal transducer and activator of transcription 3	Mus musculus	141-146
27438894-6	2016	Furthermore, ligustrazine induces down-regulation of CCL19 receptor CCR7, STAT3 and p38 MAPK protein expression.	tetramethylpyrazine	13-25	signal transducer and activator of transcription 3	Mus musculus	74-79
27438894-7	2016	Collectively, these results suggest that ligustrazine is effective in attenuation of allergic airway inflammatory changes and related chemokines and receptors in OVA-induced asthma model, and this action might be associated with inhibition of STAT3 and p38 MAPK pathway, which indicates that ligustrazine may be used as a potential therapeutic method to treat asthma.	tetramethylpyrazine	41-53	signal transducer and activator of transcription 3	Mus musculus	243-248
27089940-10	2016	Our findings demonstrate that the anti-inflammatory properties of RA are mediated in part by suppressing STAT3-mediated activation of cytokine production and cytokine receptor expression in gammadelta T cells, which suppresses their ability to activate Th17 cells.	Tretinoin	66-68	signal transducer and activator of transcription 3	Mus musculus	105-110
27240136-6	2016	Moreover, the activation of STAT3, another proinflammatory signal, was suppressed by isocyperol in LPS-stimulated RAW 264.7 cells.	isocyperol	85-95	signal transducer and activator of transcription 3	Mus musculus	28-33
27240136-9	2016	Taken together, these data indicate that isocyperol suppress septic shock through negative regulation of pro-inflammatory factors through inhibition of the NF-kappaB and STAT3 pathways and ROS.	isocyperol	41-51	signal transducer and activator of transcription 3	Mus musculus	170-175
27261558-0	2016	Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-kappaB and JNK/p38 MAPK signaling pathways.	5-deoxykaempferol	0-14	signal transducer and activator of transcription 3	Mus musculus	102-107
27431437-10	2016	Furthermore, we showed that GTW suppressed Th17 function through the inhibition of STAT3 phosphorylation.	GTW	28-31	signal transducer and activator of transcription 3	Mus musculus	83-88
27203698-6	2016	The STAT3 inhibitor JSI-124 and a specific short hairpin RNA completely abrogated the effects of progesterone on granulocytic myeloid-derived suppressor cells.	cucurbitacin I	20-27	signal transducer and activator of transcription 3	Mus musculus	4-9
27203698-6	2016	The STAT3 inhibitor JSI-124 and a specific short hairpin RNA completely abrogated the effects of progesterone on granulocytic myeloid-derived suppressor cells.	Progesterone	97-109	signal transducer and activator of transcription 3	Mus musculus	4-9
26957211-0	2016	Epigallocatechin-3-gallate ameliorates autoimmune arthritis by reciprocal regulation of T helper-17 regulatory T cells and inhibition of osteoclastogenesis by inhibiting STAT3 signaling.	epigallocatechin gallate	0-26	signal transducer and activator of transcription 3	Mus musculus	170-175
26957211-7	2016	The expression of cytokines, oxidative stress proteins, and phosphorylated-signal transducer and activator of transcription-3, 705 and 727, were significantly less in mice treated with epigallocatechin-3-gallate than it was in controls.	epigallocatechin gallate	185-211	signal transducer and activator of transcription 3	Mus musculus	75-125
26957211-12	2016	At the molecular level, the antiarthritic effects of epigallocatechin-3-gallate may be due to induction of phosphorylated-extracellular signal-regulated kinase, nuclear respiratory factor 2, and heme oxygenase-1 and inhibition of signal transducer and activator of transcription-3 activation.	epigallocatechin gallate	53-79	signal transducer and activator of transcription 3	Mus musculus	230-280
27367057-0	2016	Chlorogenic acid inhibits cholestatic liver injury induced by alpha-naphthylisothiocyanate: involvement of STAT3 and NFkappaB signalling regulation.	Chlorogenic Acid	0-16	signal transducer and activator of transcription 3	Mus musculus	107-112
27367057-0	2016	Chlorogenic acid inhibits cholestatic liver injury induced by alpha-naphthylisothiocyanate: involvement of STAT3 and NFkappaB signalling regulation.	1-Naphthylisothiocyanate	62-90	signal transducer and activator of transcription 3	Mus musculus	107-112
27311853-0	2016	N"-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFkappaB/IL-6/STAT3 pathway.	n"-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide	0-61	signal transducer and activator of transcription 3	Mus musculus	163-168
27311853-0	2016	N"-[(3-[benzyloxy]benzylidene]-3,4,5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFkappaB/IL-6/STAT3 pathway.	Dextran Sulfate	107-129	signal transducer and activator of transcription 3	Mus musculus	163-168
27311853-2	2016	In this study, we discovered the inhibitory activity of the polyphenol compound (1) in DSS induced colitis in mice by targeting NFkappaB/IL-6/STAT3 pathway.	Polyphenols	60-70	signal transducer and activator of transcription 3	Mus musculus	142-147
27311853-7	2016	Moreover, this polyphenol suppressed p-STAT3 production as well as its downstream proteins response for apoptosis, such as Bcl-2 and Bax.	Polyphenols	15-25	signal transducer and activator of transcription 3	Mus musculus	39-44
27537526-0	2016	Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model.	luteolin-7-glucoside	0-20	signal transducer and activator of transcription 3	Mus musculus	36-41
27574508-9	2016	It also inhibited the expression of interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha) mRNA and phosphorylation of STAT3 in colitis mice markedly, reduced the myeloperoxidase (MPO) level, and increased the superoxide dismutase and catalase level in colon and serum compared with DSS group.	Dextran Sulfate	302-305	signal transducer and activator of transcription 3	Mus musculus	138-143
27574508-11	2016	These results suggest that oral administration of sodium propionate could ameliorate DSS-induced colitis mainly by improving intestinal barrier function and reducing inflammation and oxidative stress via the STAT3 signaling pathway.	sodium propionate	50-67	signal transducer and activator of transcription 3	Mus musculus	208-213
27574508-11	2016	These results suggest that oral administration of sodium propionate could ameliorate DSS-induced colitis mainly by improving intestinal barrier function and reducing inflammation and oxidative stress via the STAT3 signaling pathway.	Dextran Sulfate	85-88	signal transducer and activator of transcription 3	Mus musculus	208-213
27458759-0	2016	Boswellic acid disables signal transduction of IL-6-STAT-3 in Ehrlich ascites tumor bearing irradiated mice.	boswellic acid	0-14	signal transducer and activator of transcription 3	Mus musculus	52-58
27458759-2	2016	In this study, we investigated the effect of BA on the IL-6-STAT-3 signalling pathway in irradiated mice bearing solid tumors of Ehrlich ascites carcinoma (EAC).	boswellic acid	45-47	signal transducer and activator of transcription 3	Mus musculus	60-66
27458759-6	2016	We propose that BA interfered with IL-6-STAT-3 signal transduction, thereby preventing the activation of caspase-3 and subsequently triggering the process of apoptosis.	boswellic acid	16-18	signal transducer and activator of transcription 3	Mus musculus	40-46
27267892-3	2016	STAT3 is a potent oncogene that is hyperactivated by tyrosine phosphorylation early in HNSCC carcinogenesis and is a rational therapeutic target.	Tyrosine	53-61	signal transducer and activator of transcription 3	Mus musculus	0-5
27267892-7	2016	Targeting of STAT3 with Stattic resulted in a chemopreventive effect against 4-NQO-induced oral cancer (P = 0.0402).	4-Nitroquinoline-1-oxide	77-82	signal transducer and activator of transcription 3	Mus musculus	13-18
27446336-9	2016	In conclusion, the present results indicated that the protective effects of naringin against AS are exerted via the induction of ossification, suppression of inflammation and oxidative stress and the downregulation of JAK2/STAT3 in mice.	naringin	76-84	signal transducer and activator of transcription 3	Mus musculus	223-228
26794005-0	2016	Pu-erh tea extract ameliorates high-fat diet-induced nonalcoholic steatohepatitis and insulin resistance by modulating hepatic IL-6/STAT3 signaling in mice.	pu-erh	0-6	signal transducer and activator of transcription 3	Mus musculus	132-137
27270078-8	2016	Moreover, parthenolide exposure decreased the phosphorylation of STAT3 and p38, and promoted the phosphorylation of p53 in RAW264.7 cells in vitro.	parthenolide	10-22	signal transducer and activator of transcription 3	Mus musculus	65-70
27270078-10	2016	The possible molecular mechanism involves the anti-inflammatory effects of parthenolide may by suppressing the STAT3/p38 signals and enhanced the p53 signals.	parthenolide	75-87	signal transducer and activator of transcription 3	Mus musculus	111-116
26794005-10	2016	PTE treatment strikingly enhanced STAT3 phosphorylation in the livers of HFD-fed mice.	pte	0-3	signal transducer and activator of transcription 3	Mus musculus	34-39
26794005-12	2016	In contrast, PTE inhibited IL-6-induced STAT3 phosphorylation in macrophages.	pte	13-16	signal transducer and activator of transcription 3	Mus musculus	40-45
26969793-14	2016	Furthermore, the mRNA expression of IL-6 and IL-23, and the phosphorylation of STAT3 in colon tissues from DSS-treated mice were pronouncedly inhibited by berberine.	Dextran Sulfate	107-110	signal transducer and activator of transcription 3	Mus musculus	79-84
26711554-0	2016	Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3.	balsalazide	93-104	signal transducer and activator of transcription 3	Mus musculus	76-81
26969793-14	2016	Furthermore, the mRNA expression of IL-6 and IL-23, and the phosphorylation of STAT3 in colon tissues from DSS-treated mice were pronouncedly inhibited by berberine.	Berberine	155-164	signal transducer and activator of transcription 3	Mus musculus	79-84
27177723-0	2016	Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway.	garcinone	0-9	signal transducer and activator of transcription 3	Mus musculus	103-108
27177723-3	2016	Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners.	garcinone D	10-21	signal transducer and activator of transcription 3	Mus musculus	69-119
27177723-3	2016	Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners.	garcinone D	10-21	signal transducer and activator of transcription 3	Mus musculus	123-128
27177723-5	2016	Taken together, it is the first time to show that garcinone D promotes the proliferation of C17.2 neural stem cells, which may involve the STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway.	garcinone D	50-61	signal transducer and activator of transcription 3	Mus musculus	139-144
27435207-0	2016	CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3.	cpa-7	0-5	signal transducer and activator of transcription 3	Mus musculus	97-102
27340780-7	2016	Using a osteosarcoma mouse model with co-injection of MSCs with Saos-2cells, we found that inhibition of STAT3 prolonged the survival time of tumor bearing mice by suppressing tumor growth and increasing the sensitivity of tumor cells to doxorubicin.	Doxorubicin	238-249	signal transducer and activator of transcription 3	Mus musculus	105-110
27551539-7	2016	During the first 2 days of differentiation, Shp2 overexpression impaired the DMI-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) in 3T3-L1 cells and blocked the peak expression of CCAAT/enhancer-binding proteins beta and delta during preadipocyte differentiation.	dmi	77-80	signal transducer and activator of transcription 3	Mus musculus	108-158
27551539-7	2016	During the first 2 days of differentiation, Shp2 overexpression impaired the DMI-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) in 3T3-L1 cells and blocked the peak expression of CCAAT/enhancer-binding proteins beta and delta during preadipocyte differentiation.	dmi	77-80	signal transducer and activator of transcription 3	Mus musculus	160-165
27551539-8	2016	In conclusion, Shp2 downregulated the early stages of hormone-induced differentiation of 3T3-L1 cells and inhibited the expression of the first wave of transcription factors by suppressing the DMI-induced STAT3 signaling pathway.	dmi	193-196	signal transducer and activator of transcription 3	Mus musculus	205-210
26253096-7	2016	RESULTS: In chondrocytes, BCP crystals stimulated IL-6 secretion, further amplified in an autocrine loop, through signalling pathways involving Syk and PI3 kinases, Jak2 and Stat3 molecules.	bcp	26-29	signal transducer and activator of transcription 3	Mus musculus	174-179
27018293-1	2016	Hes3 is a component of the STAT3-Ser/Hes3 Signaling Axis controlling the growth and survival of neural stem cells and other plastic cells.	Serine	33-36	signal transducer and activator of transcription 3	Mus musculus	27-32
27207661-0	2016	Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	112-117
27435207-6	2016	Then we measured the expression level of the activated form of STAT3 (one targets of CPA-7) and its transcriptive activity post CPA-7 treatment by synergistically using western blot, IHC, and firefly luciferase reporter assays.	cpa-7	85-90	signal transducer and activator of transcription 3	Mus musculus	63-68
27176453-6	2016	Furthermore, CLP-induced increases in forkhead box p3 and RAR-related orphan receptor gammat (RORgammat) expression as well as signal transducer and activator of transcription (STAT3) activation were attenuated by PTX.	Pentoxifylline	214-217	signal transducer and activator of transcription 3	Mus musculus	177-182
27034404-3	2016	We found that STAT3 phosphorylation of neutrophils in Aspergillus fumigatus-infected corne as was inhibited by the JAK/STAT inhibitor Ruxolitinib, resulting in impaired fungal killing and decreased matrix metalloproteinase 9 activity.	ruxolitinib	134-145	signal transducer and activator of transcription 3	Mus musculus	14-19
27176453-7	2016	The results indicated that PTX-induced increases in cAMP may have partly restored the Treg/Th17 balance by modulating the transcription of Foxp3 and RORgammat through the STAT3 pathway.	Pentoxifylline	27-30	signal transducer and activator of transcription 3	Mus musculus	171-176
27176453-7	2016	The results indicated that PTX-induced increases in cAMP may have partly restored the Treg/Th17 balance by modulating the transcription of Foxp3 and RORgammat through the STAT3 pathway.	Cyclic AMP	52-56	signal transducer and activator of transcription 3	Mus musculus	171-176
26815506-0	2016	Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	69-74
27003603-0	2016	Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.	gemcitabine	113-124	signal transducer and activator of transcription 3	Mus musculus	36-41
27003603-16	2016	CONCLUSIONS: In pancreatic tumors of mice, loss of P53 function activates JAK2-STAT3 signaling, which promotes modification of the tumor stroma and tumor growth and resistance to gemcitabine.	gemcitabine	179-190	signal transducer and activator of transcription 3	Mus musculus	79-84
27770111-0	2016	Correction: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle.	Sunitinib	12-21	signal transducer and activator of transcription 3	Mus musculus	106-111
27323684-8	2016	Mechanistically, CHIP directly promotes ubiquitin-mediated degradation of p53 and SHP-1, which results in activation of ERK1/2 and STAT3 pathways thereby ameliorating DOX-induced cardiac toxicity.	Doxorubicin	167-170	signal transducer and activator of transcription 3	Mus musculus	131-136
27287400-14	2016	CONCLUSIONS: We provide first evidence that activation of JAK/STAT3 signaling by OSM inhibits glutamate uptake in astrocytes, which results in neuronal excitotoxicity.	Glutamic Acid	94-103	signal transducer and activator of transcription 3	Mus musculus	62-67
27699272-5	2016	Long-term treatment with FTY720 induced significant lymphopenia and suppressed Th17 response in the peripheral immune system via downregulating STAT3 phosphorylation in both WT and S1PR1(S5A) mice.	Fingolimod Hydrochloride	25-31	signal transducer and activator of transcription 3	Mus musculus	144-149
27314291-0	2016	Salidroside reduces renal cell carcinoma proliferation by inhibiting JAK2/STAT3 signaling.	rhodioloside	0-11	signal transducer and activator of transcription 3	Mus musculus	74-79
27314291-9	2016	Higher concentrations of salidroside reduced the levels of phosphorylated signal transducer and activator of transcription 3 (STAT3) and Janus kinase 2 (JAK2).	rhodioloside	25-36	signal transducer and activator of transcription 3	Mus musculus	74-124
27314291-9	2016	Higher concentrations of salidroside reduced the levels of phosphorylated signal transducer and activator of transcription 3 (STAT3) and Janus kinase 2 (JAK2).	rhodioloside	25-36	signal transducer and activator of transcription 3	Mus musculus	126-131
27314291-10	2016	These results suggested that salidroside produced potent anticancer properties in renal cell carcinoma by modulating JAK2/STAT3 signaling.	rhodioloside	29-40	signal transducer and activator of transcription 3	Mus musculus	122-127
27145454-11	2016	The impeded cancer progression was due to the inhibitory effect of metformin on STAT3-ERK-vimentin and fibronectin-integrin signaling to decrease tumor cell invasion and de-differentiation.	Metformin	67-76	signal transducer and activator of transcription 3	Mus musculus	80-85
27127878-6	2016	Moreover, the experiments on tumor-bearing mice showed that GW4064/CDDP co-treatment inhibited the tumor growth in vivo by up-regulating SHP expression and down-regulating STAT3 phosphorylation.	GW 4064	60-66	signal transducer and activator of transcription 3	Mus musculus	172-177
27127878-6	2016	Moreover, the experiments on tumor-bearing mice showed that GW4064/CDDP co-treatment inhibited the tumor growth in vivo by up-regulating SHP expression and down-regulating STAT3 phosphorylation.	Cisplatin	67-71	signal transducer and activator of transcription 3	Mus musculus	172-177
27275094-16	2016	CONCLUSION: Exogenous recombinant IL-22 protects mice against L-arginine-induced SAP-associated lung injury by enhancing the expression of anti-apoptosis genes through the STAT3 signaling pathway.	Arginine	62-72	signal transducer and activator of transcription 3	Mus musculus	172-177
27258062-3	2016	Gene associated with retinoid interferon induced mortality (Grim) 19 is an endogenous specific inhibitor of STAT3, which regulates the expression of proinflammatory cytokines.	Retinoids	21-29	signal transducer and activator of transcription 3	Mus musculus	108-113
27085677-0	2016	Salidroside attenuates inflammatory response via suppressing JAK2-STAT3 pathway activation and preventing STAT3 transfer into nucleus.	rhodioloside	0-11	signal transducer and activator of transcription 3	Mus musculus	106-111
27111731-0	2016	Preclinical Characterization of 3beta-(N-Acetyl l-cysteine methyl ester)-2abeta,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer.	3beta-(n-acetyl l-cysteine methyl ester)-2abeta	32-79	signal transducer and activator of transcription 3	Mus musculus	137-142
27107415-4	2016	We showed that miR-1207-5p inhibited lung cancer cell A549 proliferation, migration and invasion in vitro, and suppressed the STAT3 and AKT signalings.	mir-1207-5p	15-26	signal transducer and activator of transcription 3	Mus musculus	126-131
27188969-3	2016	In the present study, the intracerebroventricular (icv) administration of the TRPV1 agonist resiniferatoxin (RTX) induced the activation of signal transducer and activator of transcription 3 (STAT3) in circumventricular organs (CVOs) and thermoregulation-associated brain regions with a similar patttern to the peripheral and icv administration of lipopolysaccharide (LPS).	resiniferatoxin	92-107	signal transducer and activator of transcription 3	Mus musculus	140-190
27188969-3	2016	In the present study, the intracerebroventricular (icv) administration of the TRPV1 agonist resiniferatoxin (RTX) induced the activation of signal transducer and activator of transcription 3 (STAT3) in circumventricular organs (CVOs) and thermoregulation-associated brain regions with a similar patttern to the peripheral and icv administration of lipopolysaccharide (LPS).	resiniferatoxin	92-107	signal transducer and activator of transcription 3	Mus musculus	192-197
27188969-3	2016	In the present study, the intracerebroventricular (icv) administration of the TRPV1 agonist resiniferatoxin (RTX) induced the activation of signal transducer and activator of transcription 3 (STAT3) in circumventricular organs (CVOs) and thermoregulation-associated brain regions with a similar patttern to the peripheral and icv administration of lipopolysaccharide (LPS).	resiniferatoxin	109-112	signal transducer and activator of transcription 3	Mus musculus	140-190
27188969-3	2016	In the present study, the intracerebroventricular (icv) administration of the TRPV1 agonist resiniferatoxin (RTX) induced the activation of signal transducer and activator of transcription 3 (STAT3) in circumventricular organs (CVOs) and thermoregulation-associated brain regions with a similar patttern to the peripheral and icv administration of lipopolysaccharide (LPS).	resiniferatoxin	109-112	signal transducer and activator of transcription 3	Mus musculus	192-197
27189061-8	2016	Sphere formation assay and colony formation assays were employed to analyze the relationship between STAT3 and miR-181b.	mir-181b	111-119	signal transducer and activator of transcription 3	Mus musculus	101-106
26868449-2	2016	The ability of either recombinant Interleukin-6 (rIL6) or pioglitazone to modulate MSC migration, essential for wound healing, by targeting the inflammation-modulated IL6/STAT3 signalling pathway was therefore investigated in bone marrow-derived MSCs from control (C57BL/6J) and pre-diabetic obese mice (B6.	Pioglitazone	58-70	signal transducer and activator of transcription 3	Mus musculus	171-176
27199988-0	2016	STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation - the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage.	Acetaminophen	115-128	signal transducer and activator of transcription 3	Mus musculus	0-5
27199988-0	2016	STAT3, a Key Parameter of Cytokine-Driven Tissue Protection during Sterile Inflammation - the Case of Experimental Acetaminophen (Paracetamol)-Induced Liver Damage.	Acetaminophen	130-141	signal transducer and activator of transcription 3	Mus musculus	0-5
27199988-5	2016	Whereas the function of key inflammatory cytokines is controversially discussed, a subclass of specific cytokines capable of efficiently activating the hepatocyte signal transducer and activator of transcription (STAT)-3 pathway stands out as being consistently protective in murine models of APAP intoxication.	Acetaminophen	293-297	signal transducer and activator of transcription 3	Mus musculus	163-220
27085677-0	2016	Salidroside attenuates inflammatory response via suppressing JAK2-STAT3 pathway activation and preventing STAT3 transfer into nucleus.	rhodioloside	0-11	signal transducer and activator of transcription 3	Mus musculus	66-71
27085677-10	2016	Further studies revealed that SAL down-regulated the phosphorylation of JAK2-STAT3 signaling pathway and reduced the nuclear translocation of STAT3 induced by LPS in RAW264.7 cells and primary peritoneal macrophages.	rhodioloside	30-33	signal transducer and activator of transcription 3	Mus musculus	77-82
27085677-10	2016	Further studies revealed that SAL down-regulated the phosphorylation of JAK2-STAT3 signaling pathway and reduced the nuclear translocation of STAT3 induced by LPS in RAW264.7 cells and primary peritoneal macrophages.	rhodioloside	30-33	signal transducer and activator of transcription 3	Mus musculus	142-147
27085677-12	2016	Taken together, these data indicated that SAL exerted anti-inflammatory action via down-regulating LPS-induced activation of JAK2-STAT3 pathway and suppressing STAT3 transfer into the nucleus at least in part.	rhodioloside	42-45	signal transducer and activator of transcription 3	Mus musculus	130-135
27085677-12	2016	Taken together, these data indicated that SAL exerted anti-inflammatory action via down-regulating LPS-induced activation of JAK2-STAT3 pathway and suppressing STAT3 transfer into the nucleus at least in part.	rhodioloside	42-45	signal transducer and activator of transcription 3	Mus musculus	160-165
28087904-0	2016	[Protective effect of diosgenin on chondrocytes mediated by JAK2/STAT3 signaling pathway in mice with osteoarthritis].	Diosgenin	22-31	signal transducer and activator of transcription 3	Mus musculus	65-70
28087904-9	2016	Conclusion: Diosgenin can inhibit apoptosis and increase mitochondrial oxidative stress capacity of chondrocytes in mice with osteoarthritis, which is closely related to the activation of JAK2/STAT3 signaling pathway.	Diosgenin	12-21	signal transducer and activator of transcription 3	Mus musculus	193-198
26891685-0	2016	Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-kappaB and IL-6/STAT3 as potential targets.	boldine	0-7	signal transducer and activator of transcription 3	Mus musculus	97-102
26891685-9	2016	The data demonstrated that boldine may be beneficial in colitis through selective immunomodulatory effects, which may be mediated, at least in part, by inhibition of p65-NF-kappaB and STAT3 signaling pathways.	boldine	27-34	signal transducer and activator of transcription 3	Mus musculus	184-189
26984284-0	2016	Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.	Atrazine	0-8	signal transducer and activator of transcription 3	Mus musculus	71-76
26984284-8	2016	Interestingly, RM1 cell proliferation was increased after treatment with atrazine, concomitantly with STAT3 signaling activation.	Atrazine	73-81	signal transducer and activator of transcription 3	Mus musculus	102-107
26984284-9	2016	These results suggest that atrazine promotes RM1 cell growth in vitro and in vivo by activating STAT3 signaling.	Atrazine	27-35	signal transducer and activator of transcription 3	Mus musculus	96-101
27035325-9	2016	Mechanistic experiments indicated that icariin and berberine increased hepcidin expression by activating the signal transducer and activator of transcription 3 (Stat3) and Smad1/5/8 signaling pathways.	icariin	39-46	signal transducer and activator of transcription 3	Mus musculus	109-159
27035325-9	2016	Mechanistic experiments indicated that icariin and berberine increased hepcidin expression by activating the signal transducer and activator of transcription 3 (Stat3) and Smad1/5/8 signaling pathways.	icariin	39-46	signal transducer and activator of transcription 3	Mus musculus	161-166
27035325-9	2016	Mechanistic experiments indicated that icariin and berberine increased hepcidin expression by activating the signal transducer and activator of transcription 3 (Stat3) and Smad1/5/8 signaling pathways.	Berberine	51-60	signal transducer and activator of transcription 3	Mus musculus	109-159
27035325-9	2016	Mechanistic experiments indicated that icariin and berberine increased hepcidin expression by activating the signal transducer and activator of transcription 3 (Stat3) and Smad1/5/8 signaling pathways.	Berberine	51-60	signal transducer and activator of transcription 3	Mus musculus	161-166
26526549-0	2016	JAK2/STAT3 Pathway Mediates Protection of Metallothionein Against Doxorubicin-Induced Cytotoxicity in Mouse Cardiomyocytes.	Doxorubicin	66-77	signal transducer and activator of transcription 3	Mus musculus	5-10
26526549-2	2016	In our previous study, we found that the gene expression levels of the Janus-activated kinase/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway were different between MT(-/-) cardiomyocytes and MT(+/+) cardiomyocytes when they were treated with Dox.	Doxorubicin	267-270	signal transducer and activator of transcription 3	Mus musculus	94-144
26526549-2	2016	In our previous study, we found that the gene expression levels of the Janus-activated kinase/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway were different between MT(-/-) cardiomyocytes and MT(+/+) cardiomyocytes when they were treated with Dox.	Doxorubicin	267-270	signal transducer and activator of transcription 3	Mus musculus	151-156
26526549-3	2016	Thus, this study was intended to investigate the role of JAK2/STAT3 pathway in metallothionein (MT) protection of Dox-induced cardiotoxicity.	Doxorubicin	114-117	signal transducer and activator of transcription 3	Mus musculus	62-67
26526549-4	2016	Tyrphostin AG490 (alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide) is a synthetic protein tyrosine kinase inhibitor which at first has been considered as a specific JAK2 inhibitor and can inhibit the JAK2/STAT3 signaling pathway.	Tyrphostins	0-10	signal transducer and activator of transcription 3	Mus musculus	203-208
26526549-4	2016	Tyrphostin AG490 (alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide) is a synthetic protein tyrosine kinase inhibitor which at first has been considered as a specific JAK2 inhibitor and can inhibit the JAK2/STAT3 signaling pathway.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	11-16	signal transducer and activator of transcription 3	Mus musculus	203-208
26526549-4	2016	Tyrphostin AG490 (alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide) is a synthetic protein tyrosine kinase inhibitor which at first has been considered as a specific JAK2 inhibitor and can inhibit the JAK2/STAT3 signaling pathway.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	18-63	signal transducer and activator of transcription 3	Mus musculus	203-208
26526549-9	2016	After Dox treatment, the protein expression of p-Jak2 and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity.	Doxorubicin	6-9	signal transducer and activator of transcription 3	Mus musculus	60-65
26526549-9	2016	After Dox treatment, the protein expression of p-Jak2 and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity.	Doxorubicin	6-9	signal transducer and activator of transcription 3	Mus musculus	153-158
26526549-9	2016	After Dox treatment, the protein expression of p-Jak2 and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity.	Doxorubicin	215-218	signal transducer and activator of transcription 3	Mus musculus	60-65
26526549-9	2016	After Dox treatment, the protein expression of p-Jak2 and p-Stat3 levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 pathway was partially involved in MT protection against Dox-induced cardiotoxicity.	Doxorubicin	215-218	signal transducer and activator of transcription 3	Mus musculus	153-158
27111731-0	2016	Preclinical Characterization of 3beta-(N-Acetyl l-cysteine methyl ester)-2abeta,3-dihydrogaliellalactone (GPA512), a Prodrug of a Direct STAT3 Inhibitor for the Treatment of Prostate Cancer.	3-dihydrogaliellalactone	80-104	signal transducer and activator of transcription 3	Mus musculus	137-142
27111731-2	2016	Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.	galiellalactone	0-15	signal transducer and activator of transcription 3	Mus musculus	43-48
27111731-2	2016	Galiellalactone (1), a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.	galiellalactone	0-15	signal transducer and activator of transcription 3	Mus musculus	80-85
26544779-0	2016	Convection-enhanced delivery of sorafenib and suppression of tumor progression in a murine model of brain melanoma through the inhibition of signal transducer and activator of transcription 3.	Sorafenib	32-41	signal transducer and activator of transcription 3	Mus musculus	141-191
26544779-4	2016	This study investigated if convection-enhanced delivery (CED) of sorafenib would enhance tumor control and survival via inhibition of the signal transducer and activator of transcription 3 (Stat3) pathway in a murine model of metastatic brain melanoma.	Sorafenib	65-74	signal transducer and activator of transcription 3	Mus musculus	138-188
26544779-4	2016	This study investigated if convection-enhanced delivery (CED) of sorafenib would enhance tumor control and survival via inhibition of the signal transducer and activator of transcription 3 (Stat3) pathway in a murine model of metastatic brain melanoma.	Sorafenib	65-74	signal transducer and activator of transcription 3	Mus musculus	190-195
26544779-8	2016	Sorafenib inhibited Stat3 phosphorylation in HTB65, WYC1, and B16 cells.	Sorafenib	0-9	signal transducer and activator of transcription 3	Mus musculus	20-25
26544779-10	2016	Because sorafenib targets multiple pathways, the present study demonstrated the contribution of the Stat3 pathway by showing that mouse embryonic fibroblast (MEF) Stat3 +/+ cells were significantly more sensitive to sorafenib than MEF Stat3 -/- cells.	Sorafenib	216-225	signal transducer and activator of transcription 3	Mus musculus	100-105
26544779-10	2016	Because sorafenib targets multiple pathways, the present study demonstrated the contribution of the Stat3 pathway by showing that mouse embryonic fibroblast (MEF) Stat3 +/+ cells were significantly more sensitive to sorafenib than MEF Stat3 -/- cells.	Sorafenib	216-225	signal transducer and activator of transcription 3	Mus musculus	163-168
26544779-10	2016	Because sorafenib targets multiple pathways, the present study demonstrated the contribution of the Stat3 pathway by showing that mouse embryonic fibroblast (MEF) Stat3 +/+ cells were significantly more sensitive to sorafenib than MEF Stat3 -/- cells.	Sorafenib	216-225	signal transducer and activator of transcription 3	Mus musculus	163-168
26826115-0	2016	EC-70124, a Novel Glycosylated Indolocarbazole Multikinase Inhibitor, Reverts Tumorigenic and Stem Cell Properties in Prostate Cancer by Inhibiting STAT3 and NF-kappaB.	EC-70124	0-8	signal transducer and activator of transcription 3	Mus musculus	148-153
26976243-9	2016	More importantly, the liver-restricted overexpression of STAT3 rescued glucose tolerance and ameliorated hepatic steatosis and inflammation in OSMRbeta knockout mice, whereas OSMRbeta overexpression failed to protect against hepatic steatosis, insulin resistance, and hepatic inflammation in STAT3-deficient mice.	Glucose	71-78	signal transducer and activator of transcription 3	Mus musculus	57-62
26826115-5	2016	In this study, we show that EC-70124 blocked concomitantly NF-kappaB and STAT3 in prostate cancer cells and particularly prostate CSCs, which exhibited overactivation of these transcription factors.	EC-70124	28-36	signal transducer and activator of transcription 3	Mus musculus	73-78
26826115-6	2016	Phosphorylation of IkB and STAT3 (Tyr705), the immediate targets of IKKbeta and JAK2, respectively, was rapidly inhibited in vitro by EC-70124 at concentrations that were well below plasma levels in mice.	EC-70124	134-142	signal transducer and activator of transcription 3	Mus musculus	27-32
26826115-9	2016	Notably, EC-70124 had profound effects on the prostate CSC subpopulation both in vitro and in vivo Thus, EC-70124 is a potent inhibitor of the NF-kappaB and STAT3 signaling pathways and blocked tumor growth and maintenance of prostate CSCs.	EC-70124	105-113	signal transducer and activator of transcription 3	Mus musculus	157-162
27028877-2	2016	Benzoic acid- and hydroxamic acid-based STAT3 inhibitors SH-4-054 and SH-5-007, developed previously in our laboratory, demonstrated promising activity against these resistant CML cell lines.	Benzoic Acid	0-12	signal transducer and activator of transcription 3	Mus musculus	40-45
27029485-0	2016	Caffeic Acid Inhibits Chronic UVB-Induced Cellular Proliferation Through JAK-STAT3 Signaling in Mouse Skin.	caffeic acid	0-12	signal transducer and activator of transcription 3	Mus musculus	77-82
27029485-4	2016	Caffeic acid (CA) inhibits JAK-STAT3 signaling, thereby induces apoptotic cell death by upregulating Bax, Cytochrome-C, Caspase-9 and Caspase-3 expression in mouse skin.	caffeic acid	0-12	signal transducer and activator of transcription 3	Mus musculus	31-36
26905227-5	2016	The protein levels of phosphorylated STAT3 (p-STAT3) and phosphorylated p38 (p-p38) were down-regulated in the colonic tissues of DSS-treated mice.	Dextran Sulfate	130-133	signal transducer and activator of transcription 3	Mus musculus	37-42
26905227-5	2016	The protein levels of phosphorylated STAT3 (p-STAT3) and phosphorylated p38 (p-p38) were down-regulated in the colonic tissues of DSS-treated mice.	Dextran Sulfate	130-133	signal transducer and activator of transcription 3	Mus musculus	46-51
26905227-8	2016	In conclusion, this study suggested that Pd-Ib attenuated DSS-induced acute colitis via the regulation of interleukins principally through the STAT3 and MAPK pathways.	Dextran Sulfate	58-61	signal transducer and activator of transcription 3	Mus musculus	143-148
26909593-2	2016	This study identified a new secondary resistance mechanism of gefitinib in STS, and developed new strategies to improve the effectiveness of EGFR inhibition particularly by blocking the STAT3 pathway.We demonstrated that seven STS cell lines of diverse histological origin showed resistance to gefitinib despite blockade of phosphorylated EGFR (pEGFR) and downstream signal transducers (pAKT and pERK) in PI3K/AKT and RAS/ERK pathways.	Gefitinib	294-303	signal transducer and activator of transcription 3	Mus musculus	186-191
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	NSC 74859	151-158	signal transducer and activator of transcription 3	Mus musculus	49-54
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	NSC 74859	151-158	signal transducer and activator of transcription 3	Mus musculus	84-89
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	NSC 74859	151-158	signal transducer and activator of transcription 3	Mus musculus	84-89
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	Gefitinib	162-171	signal transducer and activator of transcription 3	Mus musculus	49-54
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	Gefitinib	162-171	signal transducer and activator of transcription 3	Mus musculus	84-89
26909593-5	2016	We therefore hypothesized that the addition of a STAT3 inhibitor could overcome the STAT3 escape pathway.We found that the addition of STAT3 inhibitor S3I-201 to gefitinib achieved synergistic anti-proliferative and pro-apoptotic effects in all three STS cell lines examined.	Gefitinib	162-171	signal transducer and activator of transcription 3	Mus musculus	84-89
26980746-5	2016	Moreover, NZ restored the doxorubicin-induced immunogenic cell death and reversed the tumor-induced immunosuppression due to the production of kynurenine, by inhibiting the STAT3/indoleamine 2,3 dioxygenase axis.	Doxorubicin	26-37	signal transducer and activator of transcription 3	Mus musculus	173-178
26980746-5	2016	Moreover, NZ restored the doxorubicin-induced immunogenic cell death and reversed the tumor-induced immunosuppression due to the production of kynurenine, by inhibiting the STAT3/indoleamine 2,3 dioxygenase axis.	Kynurenine	143-153	signal transducer and activator of transcription 3	Mus musculus	173-178
26649526-0	2016	Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model.	nimbolide	0-9	signal transducer and activator of transcription 3	Mus musculus	45-50
27028877-5	2016	These studies revealed that AM-1-124, possessing a 2,3,5,6-tetrafluorophenylsulfonamide group, retained STAT3 protein affinity (Ki =15 mum), as well as selectivity over STAT1 (Ki >250 mum).	2,3,5,6-tetrafluorophenylsulfonamide	51-87	signal transducer and activator of transcription 3	Mus musculus	104-109
26936678-0	2016	Sip-jeon-dea-bo-tang, a traditional herbal medicine, ameliorates cisplatin-induced anorexia via the activation of JAK1/STAT3-mediated leptin and IL-6 production in the fat tissue of mice.	Cisplatin	65-74	signal transducer and activator of transcription 3	Mus musculus	119-124
26859226-0	2016	Targeted deletion of miR-139-5p activates MAPK, NF-kappaB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.	mir-139-5p	21-31	signal transducer and activator of transcription 3	Mus musculus	62-67
26943953-4	2016	Pathological examination of brains and spinal cords on day 28 showed that DHF treatment increased the phosphorylation of TrkB and activated downstream signaling pathways including AKT and STAT3 and reduced inflammation, demyelination and axonal loss compared to EAE controls.	6,7-dihydroxyflavone	74-77	signal transducer and activator of transcription 3	Mus musculus	188-193
26144873-0	2016	The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer.	galiellalactone	20-35	signal transducer and activator of transcription 3	Mus musculus	4-9
26784569-0	2016	Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway.	astilbin	0-8	signal transducer and activator of transcription 3	Mus musculus	130-135
26784569-7	2016	In vitro, astilbin inhibited Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibited Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions.	astilbin	10-18	signal transducer and activator of transcription 3	Mus musculus	114-119
26784569-7	2016	In vitro, astilbin inhibited Th17 cell differentiation and IL-17 secretion of isolated T cells, and inhibited Jak/Stat3 signaling in Th17 cells, while up-regulating Stat3 inhibitor SCOSE3 expression in psoriatic lesions.	astilbin	10-18	signal transducer and activator of transcription 3	Mus musculus	165-170
26919063-0	2016	Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-kappaB and Jak2-Stat3 Signaling Pathways.	schizandrin A	0-13	signal transducer and activator of transcription 3	Mus musculus	105-110
26882566-10	2016	We conclude that the novel small-molecule inhibitor AC-73 inhibits HCC mobility and invasion, probably by disrupting CD147 dimerization and thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways, which are crucial for cancer progression.	AC-73	52-57	signal transducer and activator of transcription 3	Mus musculus	184-189
26649526-9	2016	INNOVATION: The present study demonstrates the critical role of GSH/GSSG imbalance-mediated ROS production contributing to the STAT3 inhibitory and tumor-suppressive effect of NL in PCa.	Glutathione Disulfide	64-67	signal transducer and activator of transcription 3	Mus musculus	127-132
26649526-9	2016	INNOVATION: The present study demonstrates the critical role of GSH/GSSG imbalance-mediated ROS production contributing to the STAT3 inhibitory and tumor-suppressive effect of NL in PCa.	Glutathione Disulfide	68-72	signal transducer and activator of transcription 3	Mus musculus	127-132
26649526-9	2016	INNOVATION: The present study demonstrates the critical role of GSH/GSSG imbalance-mediated ROS production contributing to the STAT3 inhibitory and tumor-suppressive effect of NL in PCa.	Reactive Oxygen Species	92-95	signal transducer and activator of transcription 3	Mus musculus	127-132
26649526-10	2016	CONCLUSION: Overall, our findings indicate that NL exhibits significant anticancer effects in PCa that may be primarily mediated through the ROS-regulated inhibition of STAT3 signaling cascade.	Reactive Oxygen Species	141-144	signal transducer and activator of transcription 3	Mus musculus	169-174
26934552-9	2016	Importantly, diclofenac treatment prompted strong expression of phosphorylated Stat3 amongst individual animals and the associated 8- and 4-fold Soc3 and Il-6 induction reinforced Ghr degradation as evidenced by immunoblotting.	Diclofenac	13-23	signal transducer and activator of transcription 3	Mus musculus	79-84
26798022-12	2016	Finally, transcription factors, including STAT1, STAT3, and p65, were greatly suppressed by vorinostat treatment.	Vorinostat	92-102	signal transducer and activator of transcription 3	Mus musculus	49-54
26850477-12	2016	ARS-induced increase in c-Fos-IR in the PVN and DMH of non-transgenic mice was significantly attenuated by FIR exposure or JAK2/STAT3 inhibitor AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	144-149	signal transducer and activator of transcription 3	Mus musculus	128-133
26679051-5	2016	The combined actions of sorafenib and SC-43 enhanced SHP-1 activity, which was associated with diminished STAT3-related signals and stronger expression of apoptotic genes above that of either drug alone, culminating in increased cell death.	Sorafenib	24-33	signal transducer and activator of transcription 3	Mus musculus	106-111
26679051-5	2016	The combined actions of sorafenib and SC-43 enhanced SHP-1 activity, which was associated with diminished STAT3-related signals and stronger expression of apoptotic genes above that of either drug alone, culminating in increased cell death.	SC-43	38-43	signal transducer and activator of transcription 3	Mus musculus	106-111
26910359-0	2016	Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling.	zinc chloride	0-13	signal transducer and activator of transcription 3	Mus musculus	89-94
26910359-7	2016	Further mechanistic studies revealed that ZnCl2 transiently activated signal transducers and activators of transcription 3 (Stat3) signaling through promoting Stat3 phosphorylation.	zinc chloride	42-47	signal transducer and activator of transcription 3	Mus musculus	70-122
26910359-7	2016	Further mechanistic studies revealed that ZnCl2 transiently activated signal transducers and activators of transcription 3 (Stat3) signaling through promoting Stat3 phosphorylation.	zinc chloride	42-47	signal transducer and activator of transcription 3	Mus musculus	124-129
26910359-7	2016	Further mechanistic studies revealed that ZnCl2 transiently activated signal transducers and activators of transcription 3 (Stat3) signaling through promoting Stat3 phosphorylation.	zinc chloride	42-47	signal transducer and activator of transcription 3	Mus musculus	159-164
26910359-8	2016	Inhibition of Stat3 signaling abrogated the effects of ZnCl2 on mouse ES cell pluripotency.	zinc chloride	55-60	signal transducer and activator of transcription 3	Mus musculus	14-19
26888095-9	2016	Rapamycin attenuated lung injury by inhibiting the differentiation of Th17 cells through RORgammat and STAT3 dysfunction.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	103-108
26929598-7	2016	EGCG also exhibited an antiapoptotic and antiautophagic effect by inhibiting BNIP3 via the IL-6/JAKs/STAT3 pathway.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	101-106
26929598-8	2016	CONCLUSION: EGCG attenuated liver injury in ConA-induced hepatitis by downregulating IL-6/JAKs/STAT3/BNIP3-mediated apoptosis and autophagy.	epigallocatechin gallate	12-16	signal transducer and activator of transcription 3	Mus musculus	95-100
26687064-6	2016	STAT3 and NF-kappaB activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice.	Nicotine	63-71	signal transducer and activator of transcription 3	Mus musculus	0-5
26745676-5	2016	The in vivo effect of NF-kappaB activation is positively correlated with p-STAT3, Ki67, CK14 or beta-catenin expression, while GDFs induce significant transcriptional activation of RELA(p65), bcl-2, TNF-alpha, STAT3, EGFR and wnt5A, in vivo.	gdfs	127-131	signal transducer and activator of transcription 3	Mus musculus	210-215
26738780-10	2016	These results suggest that PF inhibits IMQ-induced psoriasis by regulating Th17 cell response and cytokine secretion via phosphorylation of Stat3.	Imiquimod	39-42	signal transducer and activator of transcription 3	Mus musculus	140-145
26830149-3	2016	In this study, nifuroxazide, an antidiarrheal agent identified as an inhibitor of Stat3, was evaluated for its anti-melanoma activity in vitro and in vivo.	nifuroxazide	15-27	signal transducer and activator of transcription 3	Mus musculus	82-87
30603389-3	2016	STX0119 is a specific inhibitor of signal transducer and activator of transcription 3 (STAT3) as a potential target for the treatment of RA.	STX-0119	0-7	signal transducer and activator of transcription 3	Mus musculus	35-85
30603389-3	2016	STX0119 is a specific inhibitor of signal transducer and activator of transcription 3 (STAT3) as a potential target for the treatment of RA.	STX-0119	0-7	signal transducer and activator of transcription 3	Mus musculus	87-92
30603389-5	2016	The objective of this study was to determine whether STX0119 could inhibit STAT3 and IL-17.	STX-0119	53-60	signal transducer and activator of transcription 3	Mus musculus	75-80
30603389-10	2016	These findings suggest that STX0119 can be used to treat autoimmune RA through inhibiting the activation of STAT3.	STX-0119	28-35	signal transducer and activator of transcription 3	Mus musculus	108-113
26741264-7	2016	Results of Western blot analysis indicated that ASP attenuated Caspase-3-dependent apoptosis by Caspase-8 and JNK-mediated pathway and inhibited the activation of IL-6/STAT3 and NF-kappaB signaling pathways in ConA-induced liver damage in mice.	Aspartic Acid	48-51	signal transducer and activator of transcription 3	Mus musculus	168-173
26376757-13	2016	The phosphorylated level of signal transducer and activator of transcription 3 (STAT3) was downregulated in spleen tissue of septic mice treated with rmMFG-E8.	rmmfg-e8	150-158	signal transducer and activator of transcription 3	Mus musculus	28-78
26334519-10	2016	Combining CUR-PEG and vaccine also dramatically downregulated the signal transducer and activator of transcription 3 pathway (76% reduction).	cur-peg	10-17	signal transducer and activator of transcription 3	Mus musculus	66-116
26376757-13	2016	The phosphorylated level of signal transducer and activator of transcription 3 (STAT3) was downregulated in spleen tissue of septic mice treated with rmMFG-E8.	rmmfg-e8	150-158	signal transducer and activator of transcription 3	Mus musculus	80-85
26694943-0	2016	STAT3 degradation mediated by calcineurin involved in the neurotoxicity of isoflurane.	Isoflurane	75-85	signal transducer and activator of transcription 3	Mus musculus	0-5
26694943-3	2016	The aim of this study was to determine whether isoflurane would target STAT3 to deliver its neurotoxicity.	Isoflurane	47-57	signal transducer and activator of transcription 3	Mus musculus	71-76
26694943-5	2016	Our data showed that isoflurane exposure downregulated the STAT3 survival pathway in the brain of mice and in primary neurons, whereas the mRNA levels of STAT3 remained unchanged after isoflurane exposure.	Isoflurane	21-31	signal transducer and activator of transcription 3	Mus musculus	59-64
26694943-5	2016	Our data showed that isoflurane exposure downregulated the STAT3 survival pathway in the brain of mice and in primary neurons, whereas the mRNA levels of STAT3 remained unchanged after isoflurane exposure.	Isoflurane	185-195	signal transducer and activator of transcription 3	Mus musculus	154-159
26694943-6	2016	We found that inhibiting the activity of calcineurin, which specifically promotes STAT3 degradation, alleviated isoflurane-induced neural apoptosis.	Isoflurane	112-122	signal transducer and activator of transcription 3	Mus musculus	82-87
26694943-8	2016	These findings suggest that isoflurane-induced neurotoxicity may stem from STAT3 degradation, partially through the activation of calcineurin.	Isoflurane	28-38	signal transducer and activator of transcription 3	Mus musculus	75-80
30873458-8	2016	At 3 mths, there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt, with increased liver injury (serum ALT), hepatocyte apoptosis (M30-positive cells) and proliferation (cyclin D1, cyclin E, PCNA), but neither NF-kappaB nor STAT3 activation.	Diethylnitrosamine	53-56	signal transducer and activator of transcription 3	Mus musculus	239-244
30873458-12	2016	Conclusions: Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-kappaB or IL-6/STAT3 activation, nor to sustained mTORC1 activation.	Diethylnitrosamine	25-28	signal transducer and activator of transcription 3	Mus musculus	166-171
26154696-6	2016	RESULTS: H2S suppressed lipopolysaccharide (LPS)-induced hepcidin production and regulated iron homeostasis in mice by decreasing serum interleukin-6 (IL-6) and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) activation; similar results were obtained in Huh7 cells exposed to conditioned medium from LPS-challenged THP-1 macrophages.	Hydrogen Sulfide	9-12	signal transducer and activator of transcription 3	Mus musculus	183-233
27467947-3	2016	Additionally, we showed that targeting STAT3 signaling with a tolerable selective inhibitor S3I-201 significantly decreased immature myeloid cells such as MDSCs, TAMs and iDCs in genetically defined mice HNSCC model.	s3i-	92-96	signal transducer and activator of transcription 3	Mus musculus	39-44
26154696-6	2016	RESULTS: H2S suppressed lipopolysaccharide (LPS)-induced hepcidin production and regulated iron homeostasis in mice by decreasing serum interleukin-6 (IL-6) and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) activation; similar results were obtained in Huh7 cells exposed to conditioned medium from LPS-challenged THP-1 macrophages.	Hydrogen Sulfide	9-12	signal transducer and activator of transcription 3	Mus musculus	235-240
26506421-5	2016	Specifically, cardamonin effectively abolishes chemotherapeutic drug-induced up-regulation of IL-6, IL-8 and MCP-1 and activation of NF-kappaB/IKBalpha and Stat3.	cardamonin	14-24	signal transducer and activator of transcription 3	Mus musculus	156-161
26631322-9	2016	The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation.	sodium arsenite	57-63	signal transducer and activator of transcription 3	Mus musculus	9-14
26190257-0	2016	The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase.	Desflurane	21-31	signal transducer and activator of transcription 3	Mus musculus	71-76
26190257-3	2016	We tested the hypothesis that late desflurane-induced preconditioning (DES-SWOP) is mediated via STAT3 and Pim-1.	Desflurane	35-45	signal transducer and activator of transcription 3	Mus musculus	97-102
26190257-3	2016	We tested the hypothesis that late desflurane-induced preconditioning (DES-SWOP) is mediated via STAT3 and Pim-1.	Diethylstilbestrol	71-74	signal transducer and activator of transcription 3	Mus musculus	97-102
26190257-3	2016	We tested the hypothesis that late desflurane-induced preconditioning (DES-SWOP) is mediated via STAT3 and Pim-1.	swop	75-79	signal transducer and activator of transcription 3	Mus musculus	97-102
26427439-6	2016	Our results show that Cav-1 ablation blunts STAT3 activation induced by NaIO3.	sodium iodate	72-77	signal transducer and activator of transcription 3	Mus musculus	44-49
27222070-0	2016	Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role.	geniposide	0-10	signal transducer and activator of transcription 3	Mus musculus	105-110
27222070-0	2016	Geniposide Inhibits Alpha-Naphthylisothiocyanate-Induced Intrahepatic Cholestasis: The Downregulation of STAT3 and NF[Formula: see text]B Signaling Plays an Important Role.	1-Naphthylisothiocyanate	20-48	signal transducer and activator of transcription 3	Mus musculus	105-110
27222070-10	2016	Western blot revealed that GEN inhibited the activation and expression of STAT3 and NF[Formula: see text]B.	geniposide	27-30	signal transducer and activator of transcription 3	Mus musculus	74-79
26597885-7	2016	Furthermore, IL-10 significantly inhibited the ultra-high-molecular-weight polyethylene particle-elevated phospho-STAT1 and phospho-NF-kappaB p65 productions, and promoted phospho-STAT3 expression.	Polyethylene	75-87	signal transducer and activator of transcription 3	Mus musculus	180-185
26612419-0	2016	Interaction of a small molecule Natura-alpha and STAT3-SH2 domain to block Y705 phosphorylation and inhibit lupus nephritis.	y705	75-79	signal transducer and activator of transcription 3	Mus musculus	49-54
26612419-5	2016	The phosphorylation of Y705 was prevented and making the formation of STAT3 homodimer impossible, thereby blocking STAT3 activation.	y705	23-27	signal transducer and activator of transcription 3	Mus musculus	70-75
26612419-5	2016	The phosphorylation of Y705 was prevented and making the formation of STAT3 homodimer impossible, thereby blocking STAT3 activation.	y705	23-27	signal transducer and activator of transcription 3	Mus musculus	115-120
26817244-7	2016	The detailed mechanism of these compounds showed that triptolide enhanced calcium restoration, curcumin inhibited ERK & p-STAT3 pathways, ginkolide B inhibited Ras/MAPK pathway, and steviol activated AMPK, which inhibited CFTR channel and mTOR pathway in cell and mouse models of PKD.	Curcumin	95-103	signal transducer and activator of transcription 3	Mus musculus	126-131
26465095-1	2016	Melatonin protects the heart against myocardial ischemia/reperfusion injury via the activation of the survivor activating factor enhancement (SAFE) pathway which involves tumor necrosis factor alpha (TNFalpha) and the signal transducer and activator of transcription 3 (STAT3).	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	218-268
26465095-1	2016	Melatonin protects the heart against myocardial ischemia/reperfusion injury via the activation of the survivor activating factor enhancement (SAFE) pathway which involves tumor necrosis factor alpha (TNFalpha) and the signal transducer and activator of transcription 3 (STAT3).	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	270-275
26465095-11	2016	Melatonin administered alone increased the pre-ischemic activation of mitochondrial STAT3, and this effect was attenuated with TAK242.	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	84-89
26465095-11	2016	Melatonin administered alone increased the pre-ischemic activation of mitochondrial STAT3, and this effect was attenuated with TAK242.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	127-133	signal transducer and activator of transcription 3	Mus musculus	84-89
26206265-6	2015	We also assessed activation of ALK by ethanol in cells and found that ALK and ALK-dependent extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) phosphorylation increased rapidly with ethanol exposure.	Ethanol	38-45	signal transducer and activator of transcription 3	Mus musculus	140-190
26775702-4	2016	In turn, suppression of STAT3 phosphorylation on Tyr-705 by a specific small molecule WP1066 also activates phosphorylation of the mTOR target S6 ribosomal protein.	Tyrosine	49-52	signal transducer and activator of transcription 3	Mus musculus	24-29
26562526-9	2015	JI069 suppressed symptoms of the collagen-induced arthritis (CIA) model in mice, and inhibited the cytokine production from T cells as well as the STAT3 phosphorylation of synovial cells.	ji069	0-5	signal transducer and activator of transcription 3	Mus musculus	147-152
26673664-7	2015	Although cisplatin increased serine phosphorylation of STAT1 in wild-type mice and diminished STAT3 expression in wild-type and STAT1(-/-) mice, gentamicin increased tyrosine phosphorylation of STAT3 in STAT1(-/-) mice.	Cisplatin	9-18	signal transducer and activator of transcription 3	Mus musculus	94-99
26673664-7	2015	Although cisplatin increased serine phosphorylation of STAT1 in wild-type mice and diminished STAT3 expression in wild-type and STAT1(-/-) mice, gentamicin increased tyrosine phosphorylation of STAT3 in STAT1(-/-) mice.	Gentamicins	145-155	signal transducer and activator of transcription 3	Mus musculus	194-199
26573296-6	2015	mTOR activates Stat3 by phosphorylation at serine 727 under insulin stimulation, which binds to the promoter of Ikaros, leading to its transcription priming.	Serine	43-49	signal transducer and activator of transcription 3	Mus musculus	15-20
26556875-6	2015	Combining blockade of p-STAT3 with cytotoxic drugs cisplatin, docetaxel, 5-fluorouracil (TPF) enhanced the antitumor effect in vitro and in vivo with decreased tumor sphere formation and SP cells.	Docetaxel	62-71	signal transducer and activator of transcription 3	Mus musculus	22-29
26556875-6	2015	Combining blockade of p-STAT3 with cytotoxic drugs cisplatin, docetaxel, 5-fluorouracil (TPF) enhanced the antitumor effect in vitro and in vivo with decreased tumor sphere formation and SP cells.	Fluorouracil	73-87	signal transducer and activator of transcription 3	Mus musculus	22-29
26556875-6	2015	Combining blockade of p-STAT3 with cytotoxic drugs cisplatin, docetaxel, 5-fluorouracil (TPF) enhanced the antitumor effect in vitro and in vivo with decreased tumor sphere formation and SP cells.	TPF	89-92	signal transducer and activator of transcription 3	Mus musculus	22-29
26474284-6	2015	Moreover, the combination treatment with (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol and nuclear factor kappaB (NF-kappaB) inhibitor, phenylarsine oxide (0.1 muM) or signal transducer and activator of transcription 3 (STAT3) inhibitor, Stattic (50 muM) increased the expression of Fas and DR3 more significantly.	oxophenylarsine	143-161	signal transducer and activator of transcription 3	Mus musculus	175-225
26474284-6	2015	Moreover, the combination treatment with (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol and nuclear factor kappaB (NF-kappaB) inhibitor, phenylarsine oxide (0.1 muM) or signal transducer and activator of transcription 3 (STAT3) inhibitor, Stattic (50 muM) increased the expression of Fas and DR3 more significantly.	oxophenylarsine	143-161	signal transducer and activator of transcription 3	Mus musculus	227-232
26474284-10	2015	Moreover, docking model and pull-down assay showed that (E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol directly bound to STAT3 and NF-kappaB p50 subunit.	(e)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol	56-108	signal transducer and activator of transcription 3	Mus musculus	127-132
26398946-9	2015	STAT3 phosphorylation (Tyr705) was enhanced in seipin-nKO mice, and was further elevated by rosi treatment.	Rosiglitazone	92-96	signal transducer and activator of transcription 3	Mus musculus	0-5
26668622-8	2015	EGCG could reduce the release of IL-6 and IL-17 and regulate the mouse splenic regulatory T-cell (Treg)/T helper 17 cell (Th17) ratio, while increasing the plasma levels of IL-10 and TGF-beta1 and decreasing the HIF-1alpha and STAT3 protein expression in the colon.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	227-232
26255562-10	2015	STAT3 inhibition combined with gemcitabine significantly inhibits tumor growth in both an orthotopic and the PKT mouse model of PDAC.	pdac	128-132	signal transducer and activator of transcription 3	Mus musculus	0-5
26302488-16	2015	Addition of NETs and histones to acinar cells induced formation of trypsin and activation of signal transducer and activator of transcription 3; these processes were blocked by polysialic acid.	polysialic acid	177-192	signal transducer and activator of transcription 3	Mus musculus	93-143
26770182-0	2015	3,3"-Diindolylmethane Inhibits Flt3L/GM-CSF-induced-bone Marrow-derived CD103(+) Dendritic Cell Differentiation Regulating Phosphorylation of STAT3 and STAT5.	3,3'-diindolylmethane	0-21	signal transducer and activator of transcription 3	Mus musculus	142-147
27098146-0	2016	Plasmid-Based Stat3 siRNA Delivered by Functional Graphene Oxide Suppresses Mouse Malignant Melanoma Cell Growth.	graphene oxide	50-64	signal transducer and activator of transcription 3	Mus musculus	14-19
27098146-3	2016	In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then used to deliver plasmid-based Stat3 siRNA.	graphene oxide	36-50	signal transducer and activator of transcription 3	Mus musculus	193-198
27098146-3	2016	In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then used to deliver plasmid-based Stat3 siRNA.	Polyethyleneimine	71-87	signal transducer and activator of transcription 3	Mus musculus	193-198
27098146-3	2016	In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then used to deliver plasmid-based Stat3 siRNA.	Polyethylene Glycols	92-111	signal transducer and activator of transcription 3	Mus musculus	193-198
27098146-3	2016	In this article, a novel vehicle of graphene oxide functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) was successfully synthetized and then used to deliver plasmid-based Stat3 siRNA.	go-pei-peg	113-123	signal transducer and activator of transcription 3	Mus musculus	193-198
27098146-5	2016	Moreover, molecular biology studies reveal that Stat3-related gene and protein expressions were significantly inhibited, suggesting that the formation of GO-PEI-PEG complexes could be utilized as a promising gene delivery in cancer therapy.	go-pei	154-160	signal transducer and activator of transcription 3	Mus musculus	48-53
27098146-5	2016	Moreover, molecular biology studies reveal that Stat3-related gene and protein expressions were significantly inhibited, suggesting that the formation of GO-PEI-PEG complexes could be utilized as a promising gene delivery in cancer therapy.	Polyethylene Glycols	161-164	signal transducer and activator of transcription 3	Mus musculus	48-53
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Glycine	48-55	signal transducer and activator of transcription 3	Mus musculus	184-234
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Glycine	48-55	signal transducer and activator of transcription 3	Mus musculus	236-241
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Arginine	81-89	signal transducer and activator of transcription 3	Mus musculus	184-234
26675719-4	2015	Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).	Arginine	81-89	signal transducer and activator of transcription 3	Mus musculus	236-241
26675719-5	2015	We demonstrate that such membrane-proximal STAT3 binding motifs in the germline of type I membrane receptors enhance STAT3 tyrosine phosphorylation by recruiting STAT3 proteins to the inner cell membrane.	Tyrosine	123-131	signal transducer and activator of transcription 3	Mus musculus	43-48
26675719-5	2015	We demonstrate that such membrane-proximal STAT3 binding motifs in the germline of type I membrane receptors enhance STAT3 tyrosine phosphorylation by recruiting STAT3 proteins to the inner cell membrane.	Tyrosine	123-131	signal transducer and activator of transcription 3	Mus musculus	117-122
26675719-5	2015	We demonstrate that such membrane-proximal STAT3 binding motifs in the germline of type I membrane receptors enhance STAT3 tyrosine phosphorylation by recruiting STAT3 proteins to the inner cell membrane.	Tyrosine	123-131	signal transducer and activator of transcription 3	Mus musculus	117-122
26510913-7	2015	Furthermore, we observed reduced STAT3 signaling in silibinin-treated cancer cells.	Silybin	52-61	signal transducer and activator of transcription 3	Mus musculus	33-38
26510913-8	2015	Overexpression of constitutively active STAT3 was sufficient to substantially revert the silibinin-induced downregulation of c-MYC and the metabolic phenotype.	Silybin	89-98	signal transducer and activator of transcription 3	Mus musculus	40-45
26343046-0	2015	Protective effect of Fenofibrate in renal ischemia reperfusion injury: Involved in suppressing kinase 2 (JAK2)/transcription 3 (STAT3)/p53 signaling activation.	Fenofibrate	21-32	signal transducer and activator of transcription 3	Mus musculus	128-133
26343046-9	2015	RESULTS: Fenofibrate precondition can significantly alleviate the renal dysfunction, the pathological change, up-regulate the expression of p-PPAR-alpha, Bcl-2, Bcl-xl, Caspase3 and down-regulate the expression of p-JAK2, p-STAT3, p53, p21, CytC and Bax induced by renal IR injury.	Fenofibrate	9-20	signal transducer and activator of transcription 3	Mus musculus	224-229
26343046-10	2015	CONCLUSION: Fenofibrate precondition can protect mice against IRI by suppressing p53-mediating apoptosis which was associated with inhibiting JAK2/STAT3 signaling activation though further activating PPAR-alpha.	Fenofibrate	12-23	signal transducer and activator of transcription 3	Mus musculus	147-152
26177470-0	2015	S-Nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma.	S-Nitrosoglutathione	0-20	signal transducer and activator of transcription 3	Mus musculus	30-35
26177470-0	2015	S-Nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma.	Cisplatin	79-88	signal transducer and activator of transcription 3	Mus musculus	30-35
26177470-2	2015	Recent studies have reported that GSNO regulates the activities of STAT3 and NF-kappaB via S-nitrosylation dependent mechanisms.	S-Nitrosoglutathione	34-38	signal transducer and activator of transcription 3	Mus musculus	67-72
26177470-5	2015	All three cell lines had constitutively activated (phosphorylated) STAT3 (Tyr(705)).	Tyrosine	74-77	signal transducer and activator of transcription 3	Mus musculus	67-72
26177470-6	2015	GSNO treatment of these cell lines reversibly decreased the STAT3 phosphorylation in a concentration dependent manner.	S-Nitrosoglutathione	0-4	signal transducer and activator of transcription 3	Mus musculus	60-65
26177470-8	2015	The reduced STAT3/NF-kappaB activity by GSNO treatment was correlated with the decreased cell proliferation and increased apoptosis of HNSCC cells.	S-Nitrosoglutathione	40-44	signal transducer and activator of transcription 3	Mus musculus	12-17
26177470-10	2015	Accordingly, GSNO treatment also resulted in decreased levels of phosphorylated STAT3.	S-Nitrosoglutathione	13-17	signal transducer and activator of transcription 3	Mus musculus	80-85
26177470-11	2015	In summary, these studies demonstrate that GSNO treatment blocks the NF-kappaB and STAT3 pathways which are responsible for cell survival, proliferation and that GSNO mediated mechanisms complement cispaltin and radiation therapy, and thus could potentiate the therapeutic effect in HNSCC.	S-Nitrosoglutathione	43-47	signal transducer and activator of transcription 3	Mus musculus	83-88
26177470-11	2015	In summary, these studies demonstrate that GSNO treatment blocks the NF-kappaB and STAT3 pathways which are responsible for cell survival, proliferation and that GSNO mediated mechanisms complement cispaltin and radiation therapy, and thus could potentiate the therapeutic effect in HNSCC.	cispaltin	198-207	signal transducer and activator of transcription 3	Mus musculus	83-88
26150336-2	2015	In the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on the self-renewal and apoptosis of GSCs, and if its action is associated with signal transducer and activator of transcription 3 (STAT3) pathway.	cardamonin	53-63	signal transducer and activator of transcription 3	Mus musculus	227-232
26497686-5	2015	The populations of cytotoxic T, NK and dendritic cells was inhibited and NF-kappaB and STAT3 activities were significantly lowered in the CAIA and LPS-treated IL-32beta transgenic mice.	caia	138-142	signal transducer and activator of transcription 3	Mus musculus	87-92
26536361-0	2015	FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity.	fl3	0-3	signal transducer and activator of transcription 3	Mus musculus	83-88
26536361-0	2015	FL3, a Synthetic Flavagline and Ligand of Prohibitins, Protects Cardiomyocytes via STAT3 from Doxorubicin Toxicity.	Doxorubicin	94-105	signal transducer and activator of transcription 3	Mus musculus	83-88
26536361-6	2015	FL3 induces heterodimerization of PHB1 with STAT3, thereby ensuring cardioprotection from doxorubicin toxicity.	fl3	0-3	signal transducer and activator of transcription 3	Mus musculus	44-49
26536361-6	2015	FL3 induces heterodimerization of PHB1 with STAT3, thereby ensuring cardioprotection from doxorubicin toxicity.	Doxorubicin	90-101	signal transducer and activator of transcription 3	Mus musculus	44-49
26536361-8	2015	A JAK2 inhibitor, WP1066, suppresses both the phosphorylation of STAT3 and the protective effect of FL3 in cardiomyocytes.	WP1066	18-24	signal transducer and activator of transcription 3	Mus musculus	65-70
26536361-11	2015	CONCLUSION: Activation of mitochondrial STAT3/PHB1 complex by PHB ligands may be a new strategy against doxorubicin-induced cardiotoxicity and possibly other cardiac problems.	Doxorubicin	104-115	signal transducer and activator of transcription 3	Mus musculus	40-45
26352378-9	2015	Moreover, intrathecal pretreatment with the CaMKII inhibitor KN-93 or the JAK2-STAT3 cascade inhibitor AG490 attenuated recombinant IL-33-induced nociceptive behaviors and NMDA subunit 1 up-regulation in naive mice.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	103-108	signal transducer and activator of transcription 3	Mus musculus	79-84
26352378-9	2015	Moreover, intrathecal pretreatment with the CaMKII inhibitor KN-93 or the JAK2-STAT3 cascade inhibitor AG490 attenuated recombinant IL-33-induced nociceptive behaviors and NMDA subunit 1 up-regulation in naive mice.	N-Methylaspartate	172-176	signal transducer and activator of transcription 3	Mus musculus	79-84
25887270-6	2015	NSC74859, an inhibitor of STAT-3, affected neither the proliferation rate nor ACh cell content, whereas the more sensitive STAT-3 inhibitor FLLL31 reduced the proliferation rate and increased ACh cell content by about 3-fold.	FLLL 31	140-146	signal transducer and activator of transcription 3	Mus musculus	123-129
26206265-6	2015	We also assessed activation of ALK by ethanol in cells and found that ALK and ALK-dependent extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) phosphorylation increased rapidly with ethanol exposure.	Ethanol	38-45	signal transducer and activator of transcription 3	Mus musculus	192-197
26206265-6	2015	We also assessed activation of ALK by ethanol in cells and found that ALK and ALK-dependent extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) phosphorylation increased rapidly with ethanol exposure.	Ethanol	238-245	signal transducer and activator of transcription 3	Mus musculus	140-190
26206265-6	2015	We also assessed activation of ALK by ethanol in cells and found that ALK and ALK-dependent extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription 3 (STAT3) phosphorylation increased rapidly with ethanol exposure.	Ethanol	238-245	signal transducer and activator of transcription 3	Mus musculus	192-197
26206265-7	2015	Similarly, treatment of cells with recombinant MDK protein increased ALK, ERK and STAT3 phosphorylation, suggesting that ethanol may utilize MDK to activate ALK signaling.	Ethanol	121-128	signal transducer and activator of transcription 3	Mus musculus	82-87
26416445-4	2015	In the present study, we found that activation of FXR by its specific agonist GW4064 in HCC cells inhibited cell growth, induced cell cycle arrest at G1 phase, elevated p21 expression and repressed STAT3 activity.	GW 4064	78-84	signal transducer and activator of transcription 3	Mus musculus	198-203
26416445-8	2015	The in vivo study in nude mice showed that treatment with FXR ligand GW4064 could decelerate the growth of HCC xenografts, up-regulate SOCS3 and p21 expression and inhibit STAT3 phosphorylation in the xenografts.	GW 4064	69-75	signal transducer and activator of transcription 3	Mus musculus	172-177
26480340-2	2015	Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML.	naphthalenesulfonamide	161-184	signal transducer and activator of transcription 3	Mus musculus	76-81
26480340-2	2015	Herein, rhodium(II)-catalyzed, proximity-driven modification identifies the STAT3 coiled-coil domain (CCD) as a novel ligand-binding site, and we describe a new naphthalene sulfonamide inhibitor that targets the CCD, blocks STAT3 function, and halts its disease-promoting effects in vitro, in tumor growth models, and in a leukemia mouse model, validating this new therapeutic target for resistant AML.	naphthalenesulfonamide	161-184	signal transducer and activator of transcription 3	Mus musculus	224-229
26770316-0	2015	Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17.	Dextran Sulfate	44-66	signal transducer and activator of transcription 3	Mus musculus	134-139
26300395-8	2015	Exercise training and tamoxifen reduced tumor IL-6 levels, NF-kB and STAT3 expressions, and up-regulated TPM1 and PDCD4 expressions (P<0.05).	Tamoxifen	22-31	signal transducer and activator of transcription 3	Mus musculus	69-74
26770316-0	2015	Gingko biloba extract (Ginaton) ameliorates dextran sulfate sodium (DSS)-induced acute experimental colitis in mice via reducing IL-6/STAT3 and IL-23/IL-17.	Dextran Sulfate	68-71	signal transducer and activator of transcription 3	Mus musculus	134-139
26770316-9	2015	In conclusion, Ginaton ameliorates DSS-induced acute experimental colitis in mice by reducing IL-17 production, which is at least partly involved in inhibiting IL-6/STAT3 signaling pathway and IL-23/IL-17 axis.	Dextran Sulfate	35-38	signal transducer and activator of transcription 3	Mus musculus	165-170
26341832-0	2015	Leptin Suppresses the Rewarding Effects of Running via STAT3 Signaling in Dopamine Neurons.	Dopamine	74-82	signal transducer and activator of transcription 3	Mus musculus	55-60
26341832-3	2015	Leptin receptor (LepR) signaling involves activation of signal transducer and activator of transcription-3 (STAT3), including in dopamine neurons of the ventral tegmental area (VTA) that are essential for reward-relevant behavior.	Dopamine	129-137	signal transducer and activator of transcription 3	Mus musculus	56-106
26341832-3	2015	Leptin receptor (LepR) signaling involves activation of signal transducer and activator of transcription-3 (STAT3), including in dopamine neurons of the ventral tegmental area (VTA) that are essential for reward-relevant behavior.	Dopamine	129-137	signal transducer and activator of transcription 3	Mus musculus	108-113
26341832-4	2015	We found that mice lacking STAT3 in dopamine neurons exhibit greater voluntary running, an effect reversed by viral-mediated STAT3 restoration.	Dopamine	36-44	signal transducer and activator of transcription 3	Mus musculus	27-32
26341832-4	2015	We found that mice lacking STAT3 in dopamine neurons exhibit greater voluntary running, an effect reversed by viral-mediated STAT3 restoration.	Dopamine	36-44	signal transducer and activator of transcription 3	Mus musculus	125-130
26341832-6	2015	Finally, STAT3 loss-of-function reduced mesolimbic dopamine overflow and function.	Dopamine	51-59	signal transducer and activator of transcription 3	Mus musculus	9-14
26341832-7	2015	Findings suggest that leptin influences the motivational effects of running via LepR-STAT3 modulation of dopamine tone.	Dopamine	105-113	signal transducer and activator of transcription 3	Mus musculus	85-90
25331984-0	2015	Inhibition of beta-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.	Curcumin	44-52	signal transducer and activator of transcription 3	Mus musculus	31-36
26445509-3	2015	(2015) show that disruption of leptin-regulated STAT3 signaling in midbrain dopamine neurons increases the rewarding effects of running in mice, which could explain the "high" experienced by endurance runners.	Dopamine	76-84	signal transducer and activator of transcription 3	Mus musculus	48-53
26438799-9	2015	Blockade of JAK2/STAT3 signaling in the ventral tegmental area by AG490 attenuated the anxiolytic effect produced by systemic administration of leptin.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	66-71	signal transducer and activator of transcription 3	Mus musculus	17-22
25331984-5	2015	A newly synthesized curcumin analog has inhibitory potential against beta-catenin and STAT3.	Curcumin	20-28	signal transducer and activator of transcription 3	Mus musculus	86-91
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	signal transducer and activator of transcription 3	Mus musculus	29-34
25331984-11	2015	CONCLUSION: beta-Catenin and STAT3 can be pharmacologically inhibited in vivo with a curcumin analog, which effectively inhibits beta-catenin and STAT3.	Curcumin	85-93	signal transducer and activator of transcription 3	Mus musculus	146-151
26169829-8	2015	Mutations on both dimer and Ni(2+)-mediated interfaces affected the cytokine induction of STAT3 target genes.	Nickel(2+)	28-34	signal transducer and activator of transcription 3	Mus musculus	90-95
26255115-0	2015	Downregulation of STAT3 phosphorylation enhances tumoricidal effect of IL-15-activated dendritic cell against doxorubicin-resistant lymphoma and leukemia via TNF-alpha.	Doxorubicin	110-121	signal transducer and activator of transcription 3	Mus musculus	18-23
26255115-2	2015	The present study investigated the antitumor efficacy of recombinant IL-15 in combination with the STAT3 inhibitor cucurbitacin-I in a doxorubicin-resistant murine lymphoma model.	cucurbitacin I	115-129	signal transducer and activator of transcription 3	Mus musculus	99-104
26255115-5	2015	Doxorubicin-resistant DL cells have elevated levels of Bcl-2 and Mcl-1 and increased phosphorylation of STAT3.	Doxorubicin	0-11	signal transducer and activator of transcription 3	Mus musculus	104-109
26255115-7	2015	Doxorubicin resistant Dalton"s lymphoma is susceptible to dendritic cell derived TNF-alpha upon stimulation with the STAT3 inhibitor cucurbitacin-I, which downregulates STAT3 and other survival molecules.	Doxorubicin	0-11	signal transducer and activator of transcription 3	Mus musculus	117-122
26255115-7	2015	Doxorubicin resistant Dalton"s lymphoma is susceptible to dendritic cell derived TNF-alpha upon stimulation with the STAT3 inhibitor cucurbitacin-I, which downregulates STAT3 and other survival molecules.	Doxorubicin	0-11	signal transducer and activator of transcription 3	Mus musculus	169-174
26255115-7	2015	Doxorubicin resistant Dalton"s lymphoma is susceptible to dendritic cell derived TNF-alpha upon stimulation with the STAT3 inhibitor cucurbitacin-I, which downregulates STAT3 and other survival molecules.	cucurbitacin I	133-147	signal transducer and activator of transcription 3	Mus musculus	117-122
26255115-7	2015	Doxorubicin resistant Dalton"s lymphoma is susceptible to dendritic cell derived TNF-alpha upon stimulation with the STAT3 inhibitor cucurbitacin-I, which downregulates STAT3 and other survival molecules.	cucurbitacin I	133-147	signal transducer and activator of transcription 3	Mus musculus	169-174
26452780-0	2015	Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-kappaB and STAT3 pathways.	paeonol	0-7	signal transducer and activator of transcription 3	Mus musculus	129-134
26452780-7	2015	In particular, paeonol disrupted both TNF-alpha-activated NF-kappaB and IL-6-activated STAT3 signaling pathways in B16F10 cells.	paeonol	15-22	signal transducer and activator of transcription 3	Mus musculus	87-92
26452780-10	2015	Therefore, paeonol possessed antitumor activity in melanoma cells and mice model by interruption of the aggressive feedback through proinflammatory cytokines mediated NF-kappaB and STAT3 signaling activation.	paeonol	11-18	signal transducer and activator of transcription 3	Mus musculus	181-186
24797723-0	2015	Abrogation of STAT3 signaling cascade by zerumbone inhibits proliferation and induces apoptosis in renal cell carcinoma xenograft mouse model.	zerumbone	41-50	signal transducer and activator of transcription 3	Mus musculus	14-19
24797723-2	2015	In the present report, we investigated whether zerumbone, a sesquiterpene, exerts its anticancer effect through modulation of STAT3 activation pathway.	zerumbone	47-56	signal transducer and activator of transcription 3	Mus musculus	126-131
24797723-3	2015	The pharmacological effect of zerumbone on STAT3 activation, associated protein kinases and phosphatase, and apoptosis was investigated using both RCC cell lines and xenograft mouse model.	zerumbone	30-39	signal transducer and activator of transcription 3	Mus musculus	43-48
24797723-4	2015	We observed that zerumbone suppressed STAT3 activation in a dose- and time-dependent manner in RCC cells.	zerumbone	17-26	signal transducer and activator of transcription 3	Mus musculus	38-43
24797723-6	2015	Pervanadate treatment reversed zerumbone-induced downregulation of STAT3, suggesting the involvement of a tyrosine phosphatase.	pervanadate	0-11	signal transducer and activator of transcription 3	Mus musculus	67-72
24797723-6	2015	Pervanadate treatment reversed zerumbone-induced downregulation of STAT3, suggesting the involvement of a tyrosine phosphatase.	zerumbone	31-40	signal transducer and activator of transcription 3	Mus musculus	67-72
24797723-7	2015	Indeed, we found that zerumbone induced the expression of tyrosine phosphatase SHP-1 that correlated with its ability to inhibit STAT3 activation.	zerumbone	22-31	signal transducer and activator of transcription 3	Mus musculus	129-134
24797723-8	2015	Interestingly, deletion of SHP-1 gene by siRNA abolished the ability of zerumbone to inhibit STAT3 activation.	zerumbone	72-81	signal transducer and activator of transcription 3	Mus musculus	93-98
24797723-9	2015	The inhibition of STAT3 activation by zerumbone also caused the suppression of the gene products involved in proliferation, survival, and angiogenesis.	zerumbone	38-47	signal transducer and activator of transcription 3	Mus musculus	18-23
24797723-11	2015	Overall, our results suggest for the first time that zerumbone is a novel blocker of STAT3 signaling cascade and thus has an enormous potential for the treatment of RCC and other solid tumors.	zerumbone	53-62	signal transducer and activator of transcription 3	Mus musculus	85-90
26206337-7	2015	In these cells, 2-DG inhibited the cell-surface expression of c-KIT, abrogated STAT3 and MAPK-ERK pathways, and strongly downregulated the expression of the receptor resulting in a strong in vivo effect in NOD/SCID mice xenografted with Kasumi-1 cells.	Deoxyglucose	16-20	signal transducer and activator of transcription 3	Mus musculus	79-84
26198700-0	2015	Cyclin-dependent kinase 5 represses Foxp3 gene expression and Treg development through specific phosphorylation of Stat3 at Serine 727.	Serine	124-130	signal transducer and activator of transcription 3	Mus musculus	115-120
26198700-5	2015	This effect is achieved through Cdk5 phosphorylation of the signal transducer and activator of transcription 3 (Stat3) specifically at Serine 727 in T cells, and we show this post-translational modification is required for proper Stat3 DNA binding to the Foxp3 gene on the enhancer II region.	Serine	135-141	signal transducer and activator of transcription 3	Mus musculus	60-110
26198700-5	2015	This effect is achieved through Cdk5 phosphorylation of the signal transducer and activator of transcription 3 (Stat3) specifically at Serine 727 in T cells, and we show this post-translational modification is required for proper Stat3 DNA binding to the Foxp3 gene on the enhancer II region.	Serine	135-141	signal transducer and activator of transcription 3	Mus musculus	112-117
26198700-5	2015	This effect is achieved through Cdk5 phosphorylation of the signal transducer and activator of transcription 3 (Stat3) specifically at Serine 727 in T cells, and we show this post-translational modification is required for proper Stat3 DNA binding to the Foxp3 gene on the enhancer II region.	Serine	135-141	signal transducer and activator of transcription 3	Mus musculus	230-235
26360050-2	2015	We sought to determine whether metformin reduces inflammation, by regulating p-signal transducer and activator of transcription 3 (STAT3) expression and T-helper 17 (Th17) cell proliferation, in a mouse model of inflammatory bowel disease (IBD).	Metformin	31-40	signal transducer and activator of transcription 3	Mus musculus	77-129
26360050-2	2015	We sought to determine whether metformin reduces inflammation, by regulating p-signal transducer and activator of transcription 3 (STAT3) expression and T-helper 17 (Th17) cell proliferation, in a mouse model of inflammatory bowel disease (IBD).	Metformin	31-40	signal transducer and activator of transcription 3	Mus musculus	131-136
26348153-9	2015	Mechanistically, we identified that miR-223-KO exosomes contained higher levels of Sema3A and Stat3, two known targets of miR-223 (5p &3p), than WT-exosomes.	Adenosine Monophosphate	135-138	signal transducer and activator of transcription 3	Mus musculus	94-99
25986657-5	2015	These results indicate that an increased exposure to central n-6 PUFA induces central cellular leptin resistance with concomitant defective JAK2-STAT3 and PI3K-Akt signaling.	n-6 pufa	61-69	signal transducer and activator of transcription 3	Mus musculus	145-150
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	signal transducer and activator of transcription 3	Mus musculus	104-109
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Resveratrol	34-45	signal transducer and activator of transcription 3	Mus musculus	104-109
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	Tetradecanoylphorbol Acetate	56-59	signal transducer and activator of transcription 3	Mus musculus	104-109
26617765-8	2015	Up regulated STAT 3 and down regulated TIMP-1 were significantly different in CD47 + MSC + BiAb + MB compared with CD47 + MSC or CD47 + MSC + BiAb.	Antibodies, Bispecific	91-95	signal transducer and activator of transcription 3	Mus musculus	13-19
26324318-0	2015	Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-kappab pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.	Trinitrobenzenesulfonic Acid	112-147	signal transducer and activator of transcription 3	Mus musculus	85-90
26324318-6	2015	These cytokines and LPS can induce P-gp expression through the STAT3/Nf-kappab pathway, contributing to a decrease of cyclosporine A retention, which can be reversed by the application of a P-gp inhibitor.	Cyclosporine	118-132	signal transducer and activator of transcription 3	Mus musculus	63-68
26317647-9	2015	Mechanistically, Bay60-6583-treated melanoma tissues showed increased STAT3 activation.	BAY 60-6583	17-27	signal transducer and activator of transcription 3	Mus musculus	70-75
26317647-10	2015	Inhibition of STAT3 significantly decreased the pro-tumor activity of Bay60-6583 and reduced tumor VEGF expression.	BAY 60-6583	70-80	signal transducer and activator of transcription 3	Mus musculus	14-19
26378915-4	2015	In addition, lithium has also been reported to decrease activation of the transcription factor STAT3, which is a regulator of GFAP transcription and astrogliogenesis.	Lithium	13-20	signal transducer and activator of transcription 3	Mus musculus	95-100
26378915-10	2015	Lithium reduced the levels of phosphorylated STAT3, suggesting this as one pathway mediating the effects on GFAP.	Lithium	0-7	signal transducer and activator of transcription 3	Mus musculus	45-50
26208907-2	2015	We found that pharmacologic inhibition of STAT3 or its selective knockout in cancer cells improved the tumor growth-inhibitory efficacy of anthracycline-based chemotherapies.	Anthracyclines	139-152	signal transducer and activator of transcription 3	Mus musculus	42-47
26162855-0	2015	Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway to inhibit TNF-alpha and IFN-gamma in hepatocellular carcinoma.	Indomethacin	17-29	signal transducer and activator of transcription 3	Mus musculus	140-145
26162855-9	2015	In addition, long-term use of indomethacin activates TRIF/NF-kappaB and JAK/STAT3 pathways, and indomethacin promotes the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway respectively in gammadelta T cells.	Indomethacin	30-42	signal transducer and activator of transcription 3	Mus musculus	76-81
26162855-9	2015	In addition, long-term use of indomethacin activates TRIF/NF-kappaB and JAK/STAT3 pathways, and indomethacin promotes the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway respectively in gammadelta T cells.	Indomethacin	30-42	signal transducer and activator of transcription 3	Mus musculus	186-191
26162855-10	2015	Given these findings, we drew a conclusion that long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-kappaB pathway and JAK/STAT3 pathway to inhibit TNF-alpha and IFN-gamma in HCC.	Indomethacin	65-77	signal transducer and activator of transcription 3	Mus musculus	188-193
27057441-5	2016	Most importantly, we found a COX-2/PGE2/STAT3 positive feedback loop exists in HCC cells, which could be provoked by TLR4 activation.	Dinoprostone	35-39	signal transducer and activator of transcription 3	Mus musculus	40-45
27057441-9	2016	By using a primary HCC model, we observed COX-2/PGE2/STAT3 loop was significantly blocked in TLR4-/- mice compared to wild type mice, and there was no obvious tumorgenesis sign in TLR4-/- mice.	Dinoprostone	48-52	signal transducer and activator of transcription 3	Mus musculus	53-58
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	101-110	signal transducer and activator of transcription 3	Mus musculus	65-70
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	101-110	signal transducer and activator of transcription 3	Mus musculus	143-148
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	101-110	signal transducer and activator of transcription 3	Mus musculus	143-148
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	112-114	signal transducer and activator of transcription 3	Mus musculus	65-70
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	112-114	signal transducer and activator of transcription 3	Mus musculus	143-148
26055795-2	2015	In the present study, we assessed the biological significance of STAT3 activity in subacute MI using tamoxifen (TM)-inducible cardiac-specific STAT3 knockout (STAT3 iCKO) mice.	Tamoxifen	112-114	signal transducer and activator of transcription 3	Mus musculus	143-148
26055795-8	2015	Dihydroethidium fluorescence analysis revealed that superoxide production was increased in STAT3 iCKO mice.	dihydroethidium	0-15	signal transducer and activator of transcription 3	Mus musculus	91-96
26055795-8	2015	Dihydroethidium fluorescence analysis revealed that superoxide production was increased in STAT3 iCKO mice.	Superoxides	52-62	signal transducer and activator of transcription 3	Mus musculus	91-96
25985797-5	2015	Our results show that preincubation of 3T3-L1 cells with alpha7nAChR agonist GTS-21 significantly reduces ASP-mediated chemokine MCP-1 secretion, which is regulated though nuclear factor kappaB (NFkappaB) and signal transducer and activator of transcription 3 (STAT3).	3-(2,4-dimethoxybenzylidene)anabaseine	77-83	signal transducer and activator of transcription 3	Mus musculus	209-259
25985797-5	2015	Our results show that preincubation of 3T3-L1 cells with alpha7nAChR agonist GTS-21 significantly reduces ASP-mediated chemokine MCP-1 secretion, which is regulated though nuclear factor kappaB (NFkappaB) and signal transducer and activator of transcription 3 (STAT3).	3-(2,4-dimethoxybenzylidene)anabaseine	77-83	signal transducer and activator of transcription 3	Mus musculus	261-266
25985797-6	2015	Treatment of 3T3-L1 cells with GTS-21 significantly reduced NFkappaB activation by DNA binding and STAT3 activation by disturbing post-translational modification.	3-(2,4-dimethoxybenzylidene)anabaseine	31-37	signal transducer and activator of transcription 3	Mus musculus	99-104
25732870-13	2015	By using Gnaq(-/-) mice, we demonstrated that Galphaq inhibited the differentiation of Th17 cell via regulating the activity of extracellular signal-regulated kinase-1/2 to control the expression of STAT3 (signal transducer and activator of transcription 3) and RORalpha (RAR-related orphan receptor-alpha).	gnaq	9-13	signal transducer and activator of transcription 3	Mus musculus	199-204
25616906-4	2015	FLSs were transfected with a small interfering RNA oligonucleotide (STAT3 siRNA or control siRNA).	Oligonucleotides	51-66	signal transducer and activator of transcription 3	Mus musculus	68-73
25616906-8	2015	Nicotine-induced activation of STAT3 (but not STAT1) and deactivation of STAT3 decreased the anti-inflammatory effect of nicotine.	Nicotine	0-8	signal transducer and activator of transcription 3	Mus musculus	31-36
25616906-8	2015	Nicotine-induced activation of STAT3 (but not STAT1) and deactivation of STAT3 decreased the anti-inflammatory effect of nicotine.	Nicotine	121-129	signal transducer and activator of transcription 3	Mus musculus	73-78
25616906-9	2015	AG490 inhibited the phosphorylation of STAT1 and STAT3 and decreased the TNF-alpha-induced production of pro-inflammatory mediators in RA-FLSs.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	49-54
25616906-11	2015	In conclusion, nicotine has an anti-inflammatory effect on RA by downregulating production of IL-6 and MCP-1 in FLSs, and this is mediated through activation of the JAK2-STAT3 signal pathway.	Nicotine	15-23	signal transducer and activator of transcription 3	Mus musculus	170-175
26277525-6	2015	CONCLUSION: Survivin ASODN can suppress the invasion and migration capacity of ovarian cancer cells and inhibit peritoneal metastasis of the tumor in nude mice possibly though down-regulation of IL-6/STAT3 signaling pathway.	asodn	21-26	signal transducer and activator of transcription 3	Mus musculus	200-205
28162277-7	2015	In this study, we identified that Cys259 was the target Cys residue of GSNO-mediated S-nitrosylation of STAT3.	Cysteine	34-37	signal transducer and activator of transcription 3	Mus musculus	104-109
28162277-7	2015	In this study, we identified that Cys259 was the target Cys residue of GSNO-mediated S-nitrosylation of STAT3.	S-Nitrosoglutathione	71-75	signal transducer and activator of transcription 3	Mus musculus	104-109
28162277-3	2015	STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress.	Nitric Oxide	52-64	signal transducer and activator of transcription 3	Mus musculus	0-5
28162277-8	2015	The replacement of Cys259 residue with Ala abolished the inhibitory role of GSNO in IL-6-induced STAT3 phosphorylation and transactivation, suggesting the role of Cys259S-nitrosylation in STAT3phosphorylation.	S-Nitrosoglutathione	76-80	signal transducer and activator of transcription 3	Mus musculus	97-102
28162277-3	2015	STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress.	Nitric Oxide	52-64	signal transducer and activator of transcription 3	Mus musculus	172-177
28162277-10	2015	GSNO treatment of HNSCCN cell lines reversibly decreases the activation (phosphorylation) of STAT3 in a concentration dependent manner.	S-Nitrosoglutathione	0-4	signal transducer and activator of transcription 3	Mus musculus	93-98
28162277-11	2015	The reduced STAT3/NF-kB activity by GSNO correlated with decreased cell proliferation and increased apoptosis of HNSCC cells.	S-Nitrosoglutathione	36-40	signal transducer and activator of transcription 3	Mus musculus	12-17
28162277-3	2015	STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress.	S-Nitrosoglutathione	112-132	signal transducer and activator of transcription 3	Mus musculus	0-5
26141763-11	2015	Furthermore, xanthoangelol (5-50 muM) inhibited the phosphorylation of Stat 3 without affecting the expression of the Stat 3 protein in the differentiation process of M2 macrophages, which indicated that these chalcones inhibited the differentiation of M2 macrophages.	xanthoangelol	13-26	signal transducer and activator of transcription 3	Mus musculus	71-77
28162277-3	2015	STAT3 S-nitrosylation was associated with inducible nitric oxide synthase (iNOS)-produced nitric oxide (NO) and S-nitrosoglutathione (GSNO), whereas S-glutathionylation of STAT3 was associated with cellular oxidative stress.	S-Nitrosoglutathione	134-138	signal transducer and activator of transcription 3	Mus musculus	0-5
28162277-4	2015	NO produced by iNOS or treatment of microglia with exogenous GSNO inhibited STAT3 activation via inhibiting STAT3 phosphorylation (Tyr705).	S-Nitrosoglutathione	61-65	signal transducer and activator of transcription 3	Mus musculus	76-81
28162277-4	2015	NO produced by iNOS or treatment of microglia with exogenous GSNO inhibited STAT3 activation via inhibiting STAT3 phosphorylation (Tyr705).	S-Nitrosoglutathione	61-65	signal transducer and activator of transcription 3	Mus musculus	108-113
28162277-6	2015	In cell-free kinase assay using purified JAK2 and STAT3, STAT3 phosphorylation was inhibited by its selective preincubation with GSNO, but not by preincubation of JAK2 with GSNO, indicating that GSNO-mediated mechanisms inhibit STAT3 phosphorylation through S-nitrosylation of STAT3 rather than JAK2.	S-Nitrosoglutathione	129-133	signal transducer and activator of transcription 3	Mus musculus	50-55
28162277-6	2015	In cell-free kinase assay using purified JAK2 and STAT3, STAT3 phosphorylation was inhibited by its selective preincubation with GSNO, but not by preincubation of JAK2 with GSNO, indicating that GSNO-mediated mechanisms inhibit STAT3 phosphorylation through S-nitrosylation of STAT3 rather than JAK2.	S-Nitrosoglutathione	129-133	signal transducer and activator of transcription 3	Mus musculus	57-62
28162277-6	2015	In cell-free kinase assay using purified JAK2 and STAT3, STAT3 phosphorylation was inhibited by its selective preincubation with GSNO, but not by preincubation of JAK2 with GSNO, indicating that GSNO-mediated mechanisms inhibit STAT3 phosphorylation through S-nitrosylation of STAT3 rather than JAK2.	S-Nitrosoglutathione	129-133	signal transducer and activator of transcription 3	Mus musculus	57-62
28162277-6	2015	In cell-free kinase assay using purified JAK2 and STAT3, STAT3 phosphorylation was inhibited by its selective preincubation with GSNO, but not by preincubation of JAK2 with GSNO, indicating that GSNO-mediated mechanisms inhibit STAT3 phosphorylation through S-nitrosylation of STAT3 rather than JAK2.	S-Nitrosoglutathione	129-133	signal transducer and activator of transcription 3	Mus musculus	57-62
25968579-7	2015	Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake.	parthenolide	16-28	signal transducer and activator of transcription 3	Mus musculus	70-75
25968579-7	2015	Incubation with parthenolide abolished LIF-induced glucose uptake and STAT3 Tyr(705) P, whereas incubation with LY-294002 and wortmannin suppressed both basal and LIF-induced glucose uptake and Akt Ser(473) P, indicating that JAK and PI 3-kinase signaling is required for LIF-stimulated glucose uptake.	Tyrosine	76-79	signal transducer and activator of transcription 3	Mus musculus	70-75
26141763-11	2015	Furthermore, xanthoangelol (5-50 muM) inhibited the phosphorylation of Stat 3 without affecting the expression of the Stat 3 protein in the differentiation process of M2 macrophages, which indicated that these chalcones inhibited the differentiation of M2 macrophages.	Chalcones	210-219	signal transducer and activator of transcription 3	Mus musculus	71-77
25817043-4	2015	We further assessed leptin-induced phosphorylation of the STAT-3 (pSTAT3) in various brain regions of DIO mice pretreated with mCPP or in mice genetically lacking 5-HT2C receptors.	1-(3-chlorophenyl)piperazine	127-131	signal transducer and activator of transcription 3	Mus musculus	58-64
25808463-6	2015	LCB03-0110 also inhibited hypoxia-induced HIF/STAT3 and EGF- or angiopoietin-induced signalling cascades.	3-(2-(3-(morpholinomethyl)phenyl)thieno(3,2-b)pyridin-7-ylamino)phenol	0-10	signal transducer and activator of transcription 3	Mus musculus	46-51
25808463-0	2015	Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling.	thienopyridine	28-42	signal transducer and activator of transcription 3	Mus musculus	94-99
25565605-3	2015	Literature suggests non-canonical translocation of the Signal Transducer and Activator of Transcription 3 (STAT3) to the mitochondria contributes to the regulation of the electron transport chain, cellular respiration and reactive oxygen species production.	Reactive Oxygen Species	222-245	signal transducer and activator of transcription 3	Mus musculus	55-105
25565605-3	2015	Literature suggests non-canonical translocation of the Signal Transducer and Activator of Transcription 3 (STAT3) to the mitochondria contributes to the regulation of the electron transport chain, cellular respiration and reactive oxygen species production.	Reactive Oxygen Species	222-245	signal transducer and activator of transcription 3	Mus musculus	107-112
25565605-8	2015	A positive correlation between increasing levels of ROS and dynamic changes in C/EBPbeta indicate that mitochondrial STAT3 plays a potential critical role as an initiator of the process.	Reactive Oxygen Species	52-55	signal transducer and activator of transcription 3	Mus musculus	117-122
25565605-9	2015	Based on these findings we propose a model for mitochondrial STAT3 as a regulator of ROS in adipogenesis.	Reactive Oxygen Species	85-88	signal transducer and activator of transcription 3	Mus musculus	61-66
25174402-9	2015	Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.	BP-1-102	27-35	signal transducer and activator of transcription 3	Mus musculus	79-84
25174402-9	2015	Mice therapeutically given BP-1-102, an orally bioavailable compound targeting STAT3/NF-kB activation and cross-talk, exhibit reduced colon tumorigenesis and diminished expression of STAT3/NF-kB-activating cytokines in the neoplastic areas.	BP-1-102	27-35	signal transducer and activator of transcription 3	Mus musculus	183-188
25284582-4	2015	Selective deletion of lung epithelial STAT3 in mice before cancer induction by the smoke carcinogen, urethane, resulted in increased lung tissue damage and inflammation, K-Ras oncogenic mutations and tumorigenesis.	Urethane	101-109	signal transducer and activator of transcription 3	Mus musculus	38-43
25849952-0	2015	Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways.	myricitrin	0-10	signal transducer and activator of transcription 3	Mus musculus	117-122
25849952-8	2015	Treatment with myricitrin significantly attenuated ox-LDL-induced endothelial cell apoptosis by inhibiting LOX-1 expression and by increasing the activation of the STAT3 and PI3K/Akt/eNOS signaling pathways.	myricitrin	15-25	signal transducer and activator of transcription 3	Mus musculus	164-169
26023864-3	2015	Both BF3-1 and mixture of these cyanidins at the same ratio reduced lipopolysaccharide (LPS)-induced protein level of iNOS expression and suppressed mRNA and protein expressions of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-1beta through inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) and STAT3 in murine macrophage RAW264.7 cells.	cyanidin	32-41	signal transducer and activator of transcription 3	Mus musculus	337-342
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	gossypol acetic acid	39-45	signal transducer and activator of transcription 3	Mus musculus	145-209
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	gossypol acetic acid	39-45	signal transducer and activator of transcription 3	Mus musculus	211-216
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	Cisplatin	79-88	signal transducer and activator of transcription 3	Mus musculus	145-209
26089640-2	2015	Our recent study has demonstrated that AT-101 enhanced the antitumor effect of cisplatin (CDDP) in a murine model of NSCLC via inhibition of the interleukin-6/signal transducer and activator of transcription 3 (STAT3) pathway.	Cisplatin	90-94	signal transducer and activator of transcription 3	Mus musculus	145-209
25552600-0	2015	Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: potential role in atherosclerosis.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	90-95
25713055-5	2015	We report that intestinally targeted transgenic 15-LOX-1 expression in mice inhibited azoxymethane- and dextran sodium sulfate-induced CAC, IL-6 expression, STAT3 phosphorylation, and IL-6/STAT3 downstream target (Notch3 and MUC1) expression.	Azoxymethane	86-98	signal transducer and activator of transcription 3	Mus musculus	189-194
25370454-4	2015	Meanwhile, IL-22-induced STAT3 phosphorylation and upregulation of downstream genes Bcl-2 and cyclin D1 were inhibited by metformin.	Metformin	122-131	signal transducer and activator of transcription 3	Mus musculus	25-30
25713055-5	2015	We report that intestinally targeted transgenic 15-LOX-1 expression in mice inhibited azoxymethane- and dextran sodium sulfate-induced CAC, IL-6 expression, STAT3 phosphorylation, and IL-6/STAT3 downstream target (Notch3 and MUC1) expression.	dextran sodium sulfate	104-126	signal transducer and activator of transcription 3	Mus musculus	189-194
26002932-0	2015	Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model.	Streptozocin	84-98	signal transducer and activator of transcription 3	Mus musculus	17-22
26012743-0	2015	TC-2559, an alpha4beta2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1beta through STAT3 inhibition in cultured murine macrophages.	TC 2559	0-7	signal transducer and activator of transcription 3	Mus musculus	121-126
26012743-3	2015	TC-2559 inhibited the phosphorylation of signal transducer and activator of transcription 3 (pSTAT3) but not nuclear factor-kappaB p65 after LPS.	TC 2559	0-7	signal transducer and activator of transcription 3	Mus musculus	41-91
25872592-7	2015	Our data further demonstrated that propranolol inhibited the signal transducer and activator of transcription 3 (STAT3), a critical oncogenic signaling molecule, and the anti-apoptotic protein Bcl-2.	Propranolol	35-46	signal transducer and activator of transcription 3	Mus musculus	61-111
25872592-7	2015	Our data further demonstrated that propranolol inhibited the signal transducer and activator of transcription 3 (STAT3), a critical oncogenic signaling molecule, and the anti-apoptotic protein Bcl-2.	Propranolol	35-46	signal transducer and activator of transcription 3	Mus musculus	113-118
25872592-8	2015	Additionally, overexpression of HIF-1alpha significantly reversed the inhibitory effects of propranolol on STAT3 signaling.	Propranolol	92-103	signal transducer and activator of transcription 3	Mus musculus	107-112
25872592-10	2015	Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-2 were significantly upregulated by HIF-1alpha overexpression in propranolol-treated nude mice bearing hemangiomas.	Propranolol	145-156	signal transducer and activator of transcription 3	Mus musculus	53-58
25872592-10	2015	Moreover, the protein levels of VEGF, phosphorylated STAT3, total STAT3 and Bcl-2 were significantly upregulated by HIF-1alpha overexpression in propranolol-treated nude mice bearing hemangiomas.	Propranolol	145-156	signal transducer and activator of transcription 3	Mus musculus	66-71
25872592-11	2015	Collectively, our data provide evidence that propranolol may regress infantile hemangiomas by suppressing VEGF and STAT3 signaling pathways in an HIF-1alpha-dependent manner.	Propranolol	45-56	signal transducer and activator of transcription 3	Mus musculus	115-120
26002932-9	2015	Our data indicated that the dysregulated LIF-STAT3 pathway caused by the high level of estrogen results in the impaired implantation in diabetic mice, which can be rescued by LIF, progesterone or insulin supplement.	Progesterone	180-192	signal transducer and activator of transcription 3	Mus musculus	45-50
25794850-4	2015	METHODS AND RESULTS: We generated a tamoxifen-inducible and endothelial-specific Stat3 knockout mouse model by crossbreeding Stat3(floxed/KO) and Tie2-Cre(ERT2) mice.	Tamoxifen	36-45	signal transducer and activator of transcription 3	Mus musculus	125-130
25868979-8	2015	We show that such a mechanism is relevant in vivo and underlies the action of butein, a dual STAT3-NFkB inhibitor capable of abating the chemoresistance of mesothelioma cells in vivo.	butein	78-84	signal transducer and activator of transcription 3	Mus musculus	93-98
25953027-8	2015	RESULTS: Pharmacodynamic analysis revealed that a single dose of sorafenib decreased activation of the PI3K/AKT/mTOR signaling axis at doses of 30-60 mg/kg, but activated JAK/STAT3 signaling.	Sorafenib	65-74	signal transducer and activator of transcription 3	Mus musculus	175-180
26010758-7	2015	We found that anatabine reduces the activation of STAT3 and NFkappaB in the vicinity of Abeta deposits in Tg PS1/APPswe mice resulting in a reduction of the expression of some of their target genes including Bace1, iNOS and Cox-2.	anatabine	14-23	signal transducer and activator of transcription 3	Mus musculus	50-55
25950476-10	2015	In exocrine cells isolated from mouse pancreas, geniposide could induce duct cell differentiation through upregulating TCF7L2 expression and activating JAK2/STAT3 pathway.	geniposide	48-58	signal transducer and activator of transcription 3	Mus musculus	157-162
25627799-0	2015	Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCepsilon, Stat3, and Epithelial-to-Mesenchymal Transition Markers.	plumbagin	0-9	signal transducer and activator of transcription 3	Mus musculus	112-117
25697480-0	2015	Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway.	Farnesol	0-8	signal transducer and activator of transcription 3	Mus musculus	149-154
25697480-0	2015	Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway.	Bortezomib	70-80	signal transducer and activator of transcription 3	Mus musculus	149-154
25697480-4	2015	We found that FOH suppressed both constitutive and inducible STAT3 activation at Tyr705 in MM cells.	foh	14-17	signal transducer and activator of transcription 3	Mus musculus	61-66
25697480-6	2015	Also, treatment with the protein tyrosine phosphatase (PTP) inhibitor, pervanadate treatment reversed the FOH-induced down-regulation of STAT3, possibly indicating the involvement of a PTP.	pervanadate	71-82	signal transducer and activator of transcription 3	Mus musculus	137-142
25697480-6	2015	Also, treatment with the protein tyrosine phosphatase (PTP) inhibitor, pervanadate treatment reversed the FOH-induced down-regulation of STAT3, possibly indicating the involvement of a PTP.	foh	106-109	signal transducer and activator of transcription 3	Mus musculus	137-142
25697480-7	2015	Indeed, we found that FOH treatment induces the increased expression of SHP-2 protein and knockdown of the SHP-2 gene by small interfering RNA suppressed the ability of FOH to inhibit STAT3 activation.	foh	22-25	signal transducer and activator of transcription 3	Mus musculus	184-189
25697480-7	2015	Indeed, we found that FOH treatment induces the increased expression of SHP-2 protein and knockdown of the SHP-2 gene by small interfering RNA suppressed the ability of FOH to inhibit STAT3 activation.	foh	169-172	signal transducer and activator of transcription 3	Mus musculus	184-189
25697480-10	2015	Our results suggest that FOH is a novel blocker of STAT3 signaling pathway and exerts both anti-proliferative and apoptotic activities in MM in vitro and in vivo.	foh	25-28	signal transducer and activator of transcription 3	Mus musculus	51-56
25900017-10	2015	In iPS-CMs, hypoxia and glucose/serum deprivation led to upregulation of Hsp70 transcripts and decreased STAT3 phosphorylation and total PKCepsilon protein expression.	Glucose	24-31	signal transducer and activator of transcription 3	Mus musculus	105-110
25911189-3	2015	Considering the potent cardioprotective effect of mTOR inhibitor, rapamycin, we hypothesized that reperfusion therapy with rapamycin would reduce infarct size in the diabetic hearts through STAT3 signaling.	Sirolimus	66-75	signal transducer and activator of transcription 3	Mus musculus	190-195
25911189-3	2015	Considering the potent cardioprotective effect of mTOR inhibitor, rapamycin, we hypothesized that reperfusion therapy with rapamycin would reduce infarct size in the diabetic hearts through STAT3 signaling.	Sirolimus	123-132	signal transducer and activator of transcription 3	Mus musculus	190-195
25911189-7	2015	Rapamycin treatment restored phosphorylation of STAT3 and enhanced AKT phosphorylation (target of mTORC2), but significantly reduced ribosomal protein S6 phosphorylation (target of mTORC1) in the diabetic heart.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	48-53
25911189-12	2015	STAT3 signaling plays critical role in reducing IS and attenuates cardiomyocyte death following reperfusion therapy with rapamycin in diabetic heart.	Sirolimus	121-130	signal transducer and activator of transcription 3	Mus musculus	0-5
25875801-0	2015	Metformin suppresses pancreatic tumor growth with inhibition of NFkappaB/STAT3 inflammatory signaling.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	73-78
25875801-8	2015	Furthermore, metformin treatment decreased the phosphorylation of nuclear factor kappaB and signal transducer and activator of transcription 3 as well as the expression of specificity protein 1 transcription factor and several nuclear factor kappaB-regulated genes.	Metformin	13-22	signal transducer and activator of transcription 3	Mus musculus	92-142
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	Carrageenan	132-134	signal transducer and activator of transcription 3	Mus musculus	74-79
25865044-0	2015	Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	62-67
25865044-7	2015	The anti-MM activity of icaritin was mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling.	icaritin	24-32	signal transducer and activator of transcription 3	Mus musculus	77-82
25659899-3	2015	ALA treatment of BPA attenuated ET-1-induced increases in mitochondrial superoxide (detected by MitoSox), STAT3 phosphorylation, and decreases in miR204 and SOD2 expression.	Aminolevulinic Acid	0-3	signal transducer and activator of transcription 3	Mus musculus	106-111
25659899-3	2015	ALA treatment of BPA attenuated ET-1-induced increases in mitochondrial superoxide (detected by MitoSox), STAT3 phosphorylation, and decreases in miR204 and SOD2 expression.	bisphenol A	17-20	signal transducer and activator of transcription 3	Mus musculus	106-111
25931810-3	2015	In this study, we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction.	Paclitaxel	45-55	signal transducer and activator of transcription 3	Mus musculus	70-75
25931810-3	2015	In this study, we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction.	Paclitaxel	45-55	signal transducer and activator of transcription 3	Mus musculus	77-127
25655587-4	2015	Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3.	piperine	34-42	signal transducer and activator of transcription 3	Mus musculus	87-144
28962394-7	2015	IP6 administration to the predisposed mothers prevented the proliferation, inflammation and enhanced apoptosis in F1 lung as showed by a reduction in PCNA, NF-kappaB (p50), IL-6, COX-2, pSTAT3, STAT3, miR-155 and increase in caspases, cleavage of poly (ADP-ribose) polymerase.	Phytic Acid	0-3	signal transducer and activator of transcription 3	Mus musculus	187-192
25117567-0	2015	Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-kappab, STAT3 and pro-inflammatory mediators and enhancement of IkappaBalpha and anti-inflammatory cytokines.	naringin	0-8	signal transducer and activator of transcription 3	Mus musculus	116-121
25117567-0	2015	Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-kappab, STAT3 and pro-inflammatory mediators and enhancement of IkappaBalpha and anti-inflammatory cytokines.	Carrageenan	39-50	signal transducer and activator of transcription 3	Mus musculus	116-121
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	naringin	188-196	signal transducer and activator of transcription 3	Mus musculus	74-79
25660617-7	2015	However, whole transcript expression profiling showed partly different effects of the ERAs on doxorubicin-modulated cardiac gene expression of genes involved in signal transduction (e.g. Stat3, Pim1, Akt1, Plcb2), fibrosis (e.g. Myl4), energy production (e.g. Ant1) or oxidative stress (e.g. Aox1).	Doxorubicin	94-105	signal transducer and activator of transcription 3	Mus musculus	187-192
25747392-2	2015	The purpose of the present study is to investigate the hepatoprotective effect of alisol B 23-acetate (AB23A), a natural triterpenoid from edible botanical Rhizoma alismatis, on acute hepatotoxicity induced by CCl4 in mice, and further to elucidate the involvement of farnesoid X receptor (FXR), signal transducers and activators of transcription 3 (STAT3) in the hepatoprotective effect.	alisol B 23-acetate	82-101	signal transducer and activator of transcription 3	Mus musculus	296-348
25747392-2	2015	The purpose of the present study is to investigate the hepatoprotective effect of alisol B 23-acetate (AB23A), a natural triterpenoid from edible botanical Rhizoma alismatis, on acute hepatotoxicity induced by CCl4 in mice, and further to elucidate the involvement of farnesoid X receptor (FXR), signal transducers and activators of transcription 3 (STAT3) in the hepatoprotective effect.	alisol B 23-acetate	82-101	signal transducer and activator of transcription 3	Mus musculus	350-355
25713087-0	2015	Delta9-Tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8.	Dronabinol	0-27	signal transducer and activator of transcription 3	Mus musculus	116-121
25713087-5	2015	Furthermore, promoter region methylation was decreased at Arg1 and STAT3 in THC-induced MDSCs, and consequently, such MDSCs expressed higher levels of Arg1 and STAT3.	Dronabinol	76-79	signal transducer and activator of transcription 3	Mus musculus	67-72
25713087-5	2015	Furthermore, promoter region methylation was decreased at Arg1 and STAT3 in THC-induced MDSCs, and consequently, such MDSCs expressed higher levels of Arg1 and STAT3.	Dronabinol	76-79	signal transducer and activator of transcription 3	Mus musculus	160-165
25624051-3	2015	Hence, in the present report, we investigated the effect of ascochlorin (ASC), an isoprenoid antibiotic on STAT3 activation cascade in various HCC cell lines and orthotopic mouse model.	ascochlorin	60-71	signal transducer and activator of transcription 3	Mus musculus	107-112
25624051-3	2015	Hence, in the present report, we investigated the effect of ascochlorin (ASC), an isoprenoid antibiotic on STAT3 activation cascade in various HCC cell lines and orthotopic mouse model.	ascochlorin	73-76	signal transducer and activator of transcription 3	Mus musculus	107-112
25646015-8	2015	AZD1480 treatment inhibited STAT3 phosphorylation and DNA binding, and migration and adhesion of cultured ovarian carcinoma cells and ovarian tumor growth rate, volume, and ascites production in mice.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	28-33
25822711-4	2015	Curcumin sustained the LIF independent self-renewal of mESCs and induced pluripotent stem cells (miPSCs) in a STAT3 activity dependent manner.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	110-115
25822711-6	2015	Amongst ROS genes, expression of Manganese Superoxide Dismutase (MnSOD) specifically relied on STAT3 signaling as evidenced by STAT3 inhibition and reporter assay.	ros	8-11	signal transducer and activator of transcription 3	Mus musculus	95-100
25788267-2	2015	We found that brassinin (BSN) suppressed both constitutive and IL-6-inducible STAT3 activation in lung cancer cells.	brassinin	14-23	signal transducer and activator of transcription 3	Mus musculus	78-83
25788267-2	2015	We found that brassinin (BSN) suppressed both constitutive and IL-6-inducible STAT3 activation in lung cancer cells.	brassinin	25-28	signal transducer and activator of transcription 3	Mus musculus	78-83
25788267-7	2015	Most importantly, when administered intraperitoneally, combination of BSN and paclitaxel significantly decreased the tumor development in a xenograft lung cancer mouse model associated with down-modulation of phospho-STAT3, Ki-67 and CD31.	brassinin	70-73	signal transducer and activator of transcription 3	Mus musculus	217-222
25788267-7	2015	Most importantly, when administered intraperitoneally, combination of BSN and paclitaxel significantly decreased the tumor development in a xenograft lung cancer mouse model associated with down-modulation of phospho-STAT3, Ki-67 and CD31.	Paclitaxel	78-88	signal transducer and activator of transcription 3	Mus musculus	217-222
25788267-8	2015	We suggest that BSN inhibits STAT3 signaling through modulation of PIAS-3 and SOCS-3, thereby attenuating tumor growth and increasing sensitivity to paclitaxel.	Paclitaxel	149-159	signal transducer and activator of transcription 3	Mus musculus	29-34
25568075-0	2015	In vivo and in vitro evidence that chronic activation of the hexosamine biosynthetic pathway interferes with leptin-dependent STAT3 phosphorylation.	Hexosamines	61-71	signal transducer and activator of transcription 3	Mus musculus	126-131
25568075-5	2015	Intravenous infusion of glucosamine for 3 h stimulated pSTAT3(Y705) but prevented leptin-induced phosphorylation of STAT3(S727).	Glucosamine	24-35	signal transducer and activator of transcription 3	Mus musculus	56-61
25666385-10	2015	Tyrphostin ameliorated liver injury associated with suppressed iNOS, STAT3 and pSTAT3 expression.	Tyrphostins	0-10	signal transducer and activator of transcription 3	Mus musculus	69-74
24681959-0	2015	Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer.	piperlonguminine	40-54	signal transducer and activator of transcription 3	Mus musculus	67-72
24681959-4	2015	PL inhibited Stat3 nuclear translocation, inhibited ligand-induced and constitutive Stat3 phosphorylation, and modulated expression of multiple Stat3-regulated genes.	piperlonguminine	0-2	signal transducer and activator of transcription 3	Mus musculus	13-18
24681959-4	2015	PL inhibited Stat3 nuclear translocation, inhibited ligand-induced and constitutive Stat3 phosphorylation, and modulated expression of multiple Stat3-regulated genes.	piperlonguminine	0-2	signal transducer and activator of transcription 3	Mus musculus	84-89
24681959-4	2015	PL inhibited Stat3 nuclear translocation, inhibited ligand-induced and constitutive Stat3 phosphorylation, and modulated expression of multiple Stat3-regulated genes.	piperlonguminine	0-2	signal transducer and activator of transcription 3	Mus musculus	84-89
24681959-5	2015	Surface plasmon resonance assay revealed that PL directly inhibited binding of Stat3 to its phosphotyrosyl peptide ligand.	piperlonguminine	46-48	signal transducer and activator of transcription 3	Mus musculus	79-84
24681959-11	2015	Thus, PL represents a promising new agent for rapid entry into the clinic for use in treating breast cancer, as well as other cancers in which Stat3 has a role.	piperlonguminine	6-8	signal transducer and activator of transcription 3	Mus musculus	143-148
25611565-0	2015	Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	110-115
25611565-7	2015	Moreover, blocking ERS restored the protein levels of phosphorylated STAT3 as well as BCL-2 expression, thus abolishing the chemosensitization potency of Qu; these results revealed that Qu affected the STAT3 pathway to enhance cDDP cytotoxicity, and this effect involved ERS signaling.	Cisplatin	227-231	signal transducer and activator of transcription 3	Mus musculus	202-207
25611565-9	2015	Tumors from mice treated with cDDP in combination with Qu pretreatment had repressed STAT3 phosphorylation, lower BCL-2 and higher apoptosis levels compared with those from the other groups.	Cisplatin	30-34	signal transducer and activator of transcription 3	Mus musculus	85-90
25987060-8	2015	Furthermore treatment with DNC decreased STAT3, IL-10 and arginase I gene expression (P<0.05), indicating low levels of M2 macrophage.	dnc	27-30	signal transducer and activator of transcription 3	Mus musculus	41-46
25717237-5	2015	To verify whether STAT3 and matrix metalloproteinase-9 (MMP-9) protein expression is associated with glucose-induced cell movement, Western blot was used to compare the differences in the expression of MMP-9 and STAT3 in cells incubated with and without STAT3 inhibitors in high glucose condition.	Glucose	101-108	signal transducer and activator of transcription 3	Mus musculus	18-23
25717237-7	2015	However, the glucose-induced migration and invasion were obviously inhibited by STAT3 inhibitors (P<0.05).	Glucose	13-20	signal transducer and activator of transcription 3	Mus musculus	80-85
25717237-8	2015	Similarly, in Western blot assessment, both MMP-9 and STAT3 expression increased under a high glucose environment and the highest expression was achieved when 30 mmol/L glucose was used.	Glucose	94-101	signal transducer and activator of transcription 3	Mus musculus	54-59
25717237-8	2015	Similarly, in Western blot assessment, both MMP-9 and STAT3 expression increased under a high glucose environment and the highest expression was achieved when 30 mmol/L glucose was used.	Glucose	169-176	signal transducer and activator of transcription 3	Mus musculus	54-59
25717237-9	2015	However, in cells treated with 30 mmol/L mannitol, either MMP-9 or STAT3 expression did not increase (P>0.05).	Mannitol	41-49	signal transducer and activator of transcription 3	Mus musculus	67-72
25717237-10	2015	When STAT3 inhibitors were added in the 30 mM glucose group, not only STAT3 but also MMP-9 expression decreased significantly (P<0.05).	Glucose	46-53	signal transducer and activator of transcription 3	Mus musculus	5-10
25717237-10	2015	When STAT3 inhibitors were added in the 30 mM glucose group, not only STAT3 but also MMP-9 expression decreased significantly (P<0.05).	Glucose	46-53	signal transducer and activator of transcription 3	Mus musculus	70-75
25717237-11	2015	CONCLUSION: Our study provides evidence that glucose can promote both migration and invasion of CT-26 cells, and that the STAT3-induced MMP-9 signal pathway is involved in this process.	Glucose	45-52	signal transducer and activator of transcription 3	Mus musculus	122-127
25337691-6	2015	17AAG-caused inhibition of SCC induction was accompanied by a decrease in UVR-induced (1) hyperplasia, (2) Hsp90beta-PKCe interaction, and (3) expression levels of Hsp90beta, Stat3, pStat3Ser727, pStat3Tyr705, pAktSer473, and matrix metalloproteinase (MMP).	tanespimycin	0-5	signal transducer and activator of transcription 3	Mus musculus	175-180
25582888-0	2015	PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model.	Urethane	65-73	signal transducer and activator of transcription 3	Mus musculus	46-51
25519169-9	2015	Furthermore, during DEN-induced initiation of HCC, Ct-HBx- and FL-HBx-transgenic mice showed higher expression of IL-6, TNF-alpha and IL-1beta transcripts, activation of STAT3, ERK and JNK proteins and an increase in cell apoptosis.	Diethylnitrosamine	20-23	signal transducer and activator of transcription 3	Mus musculus	170-175
25335925-9	2015	Furthermore, Pwp1 KD mESCs recover their differentiation potential through suppressing the expression of Stat3 or inhibiting the tyrosine phosphorylation of STAT3.	Tyrosine	129-137	signal transducer and activator of transcription 3	Mus musculus	157-162
25548278-9	2015	These findings demonstrate that NLRP3 regulates Stat3 signaling in alveolar epithelial cells by affecting macrophage and neutrophil function independent of IL-1beta production and contributes to the pathophysiology of HALI.	hali	218-222	signal transducer and activator of transcription 3	Mus musculus	48-53
25460504-0	2015	Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	94-99
25460504-9	2015	Among the mechanisms, we herein show that sunitinib is able to restrain the overactivation of STAT3 and MuRF-1 pathways, involved in enhanced muscle protein catabolism during cancer cachexia.	Sunitinib	42-51	signal transducer and activator of transcription 3	Mus musculus	94-99
25684945-8	2015	Western blotting was also performed to determine the expression of proteins associated with the Jak2-STAT3 signaling pathway and the apoptosis regulator proteins after the treatment with AG490, a Jak2 specific inhibitor, in B7-H3 overexpressing cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	187-192	signal transducer and activator of transcription 3	Mus musculus	101-106
25530164-12	2015	Furthermore, RSV significantly suppressed the phosphorylation of TLR4 downstream factors NF-kappaB p65, p38MAPK, and STAT3.	Resveratrol	13-16	signal transducer and activator of transcription 3	Mus musculus	117-122
25405516-0	2015	Ginsenoside 20(S)-Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells.	Ginsenosides	0-11	signal transducer and activator of transcription 3	Mus musculus	58-63
25351847-6	2015	A chemical chaperone, 4-phenylbutyrate, restored STAT3-glial fibrillary acidic protein signaling, while ER stressors, such as tunicamycin and thapsigargin, almost completely abolished signaling in cultured astrocytes.	4-phenylbutyric acid	22-38	signal transducer and activator of transcription 3	Mus musculus	49-54
25304310-10	2015	Western blot analysis revealed an increased protein expressions of COX-2, STAT-3 NF-kB p65 and PARP-1 and decreased IkB-alpha and IL-4 in the Cg group.	Carrageenan	142-144	signal transducer and activator of transcription 3	Mus musculus	74-80
25425624-3	2015	Here we show that inhibition of STAT3 signaling using the small-molecule inhibitor benzo[b]thiophene,6-nitro-,1,1-dioxide (Stattic), or by STAT3 knockdown by small interfering RNA, caused a decrease in Synpo mRNA and protein in an immortalized mouse podocyte cell line.	Thiophenes	91-100	signal transducer and activator of transcription 3	Mus musculus	32-37
25425624-3	2015	Here we show that inhibition of STAT3 signaling using the small-molecule inhibitor benzo[b]thiophene,6-nitro-,1,1-dioxide (Stattic), or by STAT3 knockdown by small interfering RNA, caused a decrease in Synpo mRNA and protein in an immortalized mouse podocyte cell line.	6-nitro-,1,1-dioxide	101-121	signal transducer and activator of transcription 3	Mus musculus	32-37
25143196-0	2015	Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.	7,3'-dihydroxy-4'-methoxyisoflavone	22-31	signal transducer and activator of transcription 3	Mus musculus	93-98
25143196-1	2015	PURPOSE: Investigating the hepatoprotective effect of calycosin against acute liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	54-63	signal transducer and activator of transcription 3	Mus musculus	130-135
25143196-5	2015	The relation between calycosin and activation of FXR and STAT3 was comfirmed using the Luciferase assay, Molecular docking, Real-time PCR and Western Blot in vitro.	7,3'-dihydroxy-4'-methoxyisoflavone	21-30	signal transducer and activator of transcription 3	Mus musculus	57-62
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	7,3'-dihydroxy-4'-methoxyisoflavone	41-50	signal transducer and activator of transcription 3	Mus musculus	139-144
25143196-8	2015	Molecular docking results indicated that calycosin could be embedded into the binding pocket of FXR, thereby increasing the expressions of STAT3 tyrosine phosphorylation and its target genes, Bcl-xl and SOCS3.	Tyrosine	145-153	signal transducer and activator of transcription 3	Mus musculus	139-144
25143196-9	2015	CONCLUSIONS: Calycosin plays a critical role in hepatoprotection against liver injury in association with FXR activation and STAT3 phosphorylation.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	125-130
25638155-0	2015	Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells.	Cisplatin	0-9	signal transducer and activator of transcription 3	Mus musculus	111-116
26137415-3	2015	Formation of Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed in STAT3Deltam mice.	Azoxymethane	13-25	signal transducer and activator of transcription 3	Mus musculus	91-96
26137415-3	2015	Formation of Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed in STAT3Deltam mice.	Dextran Sulfate	26-40	signal transducer and activator of transcription 3	Mus musculus	91-96
26137415-3	2015	Formation of Azoxymethane/Dextransulfate (AOM/DSS)-induced CRCs was strongly suppressed in STAT3Deltam mice.	Azoxymethane	42-45	signal transducer and activator of transcription 3	Mus musculus	91-96
25595264-4	2015	A microglia inhibitor minocycline largely suppressed lipopolysaccharide-induced astrocytic nuclear translocation of STAT3 in the OVLT and AP, but its effect was less in the SFO.	Minocycline	22-33	signal transducer and activator of transcription 3	Mus musculus	116-121
25593461-8	2015	Butein inhibited IL-6-induced activation of STAT3 in Colo 205 cells.	butein	0-6	signal transducer and activator of transcription 3	Mus musculus	44-49
25074339-8	2015	We found that knockdown of STAT3 or use of a STAT3 inhibitor resulted in a significant reduction in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) production, followed by decreased osteoclast formation by LPS.	Nitric Oxide	157-169	signal transducer and activator of transcription 3	Mus musculus	27-32
25074339-8	2015	We found that knockdown of STAT3 or use of a STAT3 inhibitor resulted in a significant reduction in interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and nitric oxide (NO) production, followed by decreased osteoclast formation by LPS.	Nitric Oxide	157-169	signal transducer and activator of transcription 3	Mus musculus	45-50
25074339-14	2015	INNOVATION: For the first time, we showed that LPS-induced ROS signaling is dependent on the coordinated mechanism of JNK and STAT3 during osteoclastogenesis, which is negatively regulated by PrxII.	Reactive Oxygen Species	59-62	signal transducer and activator of transcription 3	Mus musculus	126-131
25047070-13	2015	Effects of QD232 on Src/FAK and STAT3 phosphorylation were blocked by N-acetylcysteine or glutathione.	Acetylcysteine	70-86	signal transducer and activator of transcription 3	Mus musculus	32-37
26380299-0	2015	Tyrosine 705 Phosphorylation of STAT3 Is Associated with Phenotype Severity in TGFbeta1 Transgenic Mice.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	32-37
25047070-13	2015	Effects of QD232 on Src/FAK and STAT3 phosphorylation were blocked by N-acetylcysteine or glutathione.	Glutathione	90-101	signal transducer and activator of transcription 3	Mus musculus	32-37
25403850-6	2015	Dietary administration of DIM (10 mumol/g diet or 2,460 ppm) to mice treated with NTCU plus LPS reduced the incidence of LSCC by 2-fold, suppressed activation/expression of proinflammatory and procarcinogenic proteins and NF-kappaB- and STAT3-DNA binding, but not the expression of cytokines and p53.	3,3'-diindolylmethane	26-29	signal transducer and activator of transcription 3	Mus musculus	237-242
25411359-5	2015	Interestingly, anoikis-resistant cells exhibited significantly increased expression and phosphorylation of signal transducer and activation of transcription 3 (STAT3) at Tyr 705, as compared to adherent cells.	Tyrosine	170-173	signal transducer and activator of transcription 3	Mus musculus	107-158
25411359-5	2015	Interestingly, anoikis-resistant cells exhibited significantly increased expression and phosphorylation of signal transducer and activation of transcription 3 (STAT3) at Tyr 705, as compared to adherent cells.	Tyrosine	170-173	signal transducer and activator of transcription 3	Mus musculus	160-165
25411359-8	2015	Interleukin-6 treatment and overexpression of STAT3 enhanced anoikis resistance and protected the cells from PL-induced anoikis.	piplartine	109-111	signal transducer and activator of transcription 3	Mus musculus	46-51
25892397-4	2015	E2F8 is highly expressed in decidual cells and regulated by progesterone through HB-EGF/EGFR/ERK/STAT3 signaling pathway.	Progesterone	60-72	signal transducer and activator of transcription 3	Mus musculus	97-102
26202362-0	2015	Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the alpha7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells.	Acetylcholine	0-13	signal transducer and activator of transcription 3	Mus musculus	97-102
26202362-11	2015	Moreover, ACh enhanced the expression of JAK2 and STAT3, and the JAK2 inhibitor AG490 and the STAT3 inhibitor static restored the effect of ACh.	Acetylcholine	10-13	signal transducer and activator of transcription 3	Mus musculus	50-55
26202362-11	2015	Moreover, ACh enhanced the expression of JAK2 and STAT3, and the JAK2 inhibitor AG490 and the STAT3 inhibitor static restored the effect of ACh.	Acetylcholine	140-143	signal transducer and activator of transcription 3	Mus musculus	94-99
26202362-13	2015	In addition, the JAK2 and STAT3 inhibitor abolished the inhibitory effects of ACh on phosphorylation of NF-kappaB.	Acetylcholine	78-81	signal transducer and activator of transcription 3	Mus musculus	26-31
26202362-14	2015	CONCLUSIONS: Activation of alpha7 nAChR by ACh inhibited LPS-induced MMP-9 production and macrophage migration through the JAK2/STAT3 signaling pathway.	Acetylcholine	35-38	signal transducer and activator of transcription 3	Mus musculus	128-133
25294776-9	2014	Our data indicate that PE inhibits c-Jun N-terminal kinase, p38 and signal transducer and activator of transcription-3.	pe	23-25	signal transducer and activator of transcription 3	Mus musculus	68-118
25563207-5	2015	Pre-treatment of DEX or SB203580 inhibited lipopolysaccharide (LPS)-stimulated IL-10, TNF-alpha secretion, and STAT3 phosphorylation.	Dexamethasone	17-20	signal transducer and activator of transcription 3	Mus musculus	111-116
25563207-5	2015	Pre-treatment of DEX or SB203580 inhibited lipopolysaccharide (LPS)-stimulated IL-10, TNF-alpha secretion, and STAT3 phosphorylation.	SB 203580	24-32	signal transducer and activator of transcription 3	Mus musculus	111-116
25563207-7	2015	Combining DEX and SB203580 showed strong inhibition on the LPS-induced IL-10 secretion and STAT3 phosphorylation, which might reflect a very important drawback from the combined use of both anti-inflammatory agents.	Dexamethasone	10-13	signal transducer and activator of transcription 3	Mus musculus	91-96
25563207-7	2015	Combining DEX and SB203580 showed strong inhibition on the LPS-induced IL-10 secretion and STAT3 phosphorylation, which might reflect a very important drawback from the combined use of both anti-inflammatory agents.	SB 203580	18-26	signal transducer and activator of transcription 3	Mus musculus	91-96
25108518-1	2015	Signal pathways that reduce the levels of tyrosine-phosphorylated STAT3 (pSTAT3) allow late retinal progenitors to exit the cell cycle and enter a terminal differentiation pathway into rod photoreceptors.	Tyrosine	42-50	signal transducer and activator of transcription 3	Mus musculus	66-71
25561562-8	2015	Immunohistochemical staining of PANC-1 tumor xenografts showed a marked decrease in STAT3 in the tumors of mice treated with Dp44mT or DpC compared with the vehicle.	di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone	125-131	signal transducer and activator of transcription 3	Mus musculus	84-89
25561562-8	2015	Immunohistochemical staining of PANC-1 tumor xenografts showed a marked decrease in STAT3 in the tumors of mice treated with Dp44mT or DpC compared with the vehicle.	di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone	135-138	signal transducer and activator of transcription 3	Mus musculus	84-89
26075036-5	2015	In addition, allicin was capable of reducing the activation and nuclear accumulation of signal transducer and activator of transcription 3 (STAT3), thereby preventing degradation of the inhibitory protein IkappaB and inducing inhibition of the nuclear translocation of nuclear factor (NF)-kappaB-p65 in the colonic mucosa.	allicin	13-20	signal transducer and activator of transcription 3	Mus musculus	88-138
26075036-5	2015	In addition, allicin was capable of reducing the activation and nuclear accumulation of signal transducer and activator of transcription 3 (STAT3), thereby preventing degradation of the inhibitory protein IkappaB and inducing inhibition of the nuclear translocation of nuclear factor (NF)-kappaB-p65 in the colonic mucosa.	allicin	13-20	signal transducer and activator of transcription 3	Mus musculus	140-145
26075036-6	2015	These findings suggest that allicin exerts clinically useful anti-inflammatory effects mediated through the suppression of the NF-kappaB and IL-6/p-STAT3(Y705) pathways.	allicin	28-35	signal transducer and activator of transcription 3	Mus musculus	148-153
26542749-0	2015	Stat3 is a candidate epigenetic biomarker of perinatal Bisphenol A exposure associated with murine hepatic tumors with implications for human health.	bisphenol A	55-66	signal transducer and activator of transcription 3	Mus musculus	0-5
26542749-3	2015	Here, we evaluated DNA methylation at 3 candidate genes (Esr1, Il-6st, and Stat3) in liver tissue of BPA-exposed mice euthanized at 2 time points: post-natal day 22 (PND22; n = 147) or 10-months of age (n = 78, including n = 18 with hepatic tumors).	bisphenol A	101-104	signal transducer and activator of transcription 3	Mus musculus	75-80
26542749-7	2015	One of 3 candidate genes, Stat3, displayed dose-dependent DNA methylation changes in both 10-month mice with liver tumors as compared to those without liver tumors and 3-week sibling mice from the same exposure study, implicating Stat3 as a potential epigenetic biomarker of both early life BPA exposure and adult disease in mice.	bisphenol A	291-294	signal transducer and activator of transcription 3	Mus musculus	26-31
26542749-7	2015	One of 3 candidate genes, Stat3, displayed dose-dependent DNA methylation changes in both 10-month mice with liver tumors as compared to those without liver tumors and 3-week sibling mice from the same exposure study, implicating Stat3 as a potential epigenetic biomarker of both early life BPA exposure and adult disease in mice.	bisphenol A	291-294	signal transducer and activator of transcription 3	Mus musculus	230-235
26542749-9	2015	These data implicate Stat3 as a potential early life biomarker of adult murine liver tumor risk following early BPA exposure with early evidence of relevance to human health.	bisphenol A	112-115	signal transducer and activator of transcription 3	Mus musculus	21-26
25512545-3	2014	Here, we show that the expression of Stat3 is increased in PRs of the Tg(RHO P347S) and Prph2(rds) (/+) mouse models of IPD and is activated by tyrosine phosphorylation.	Tyrosine	144-152	signal transducer and activator of transcription 3	Mus musculus	37-42
25512545-7	2014	Phosphorylation of STAT3 at tyrosine 705 was required for the prosurvival effect because an R26-Stat3(Y705F) allele was not protective.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	19-24
25369127-10	2014	We have recently discovered that cyclometalated octahedral iridium(III) and rhodium(III) complexes bearing C( )N ligands based on 2-phenylpyridine could function as modulators of protein-protein interactions, such as TNF-alpha, STAT3, and mTOR.	2-phenylpyridine	130-146	signal transducer and activator of transcription 3	Mus musculus	228-233
25320076-7	2014	Furthermore, CIMO significantly decreased the tumor development in an orthotopic HCC mouse model through the modulation of phospho-STAT3, Ki-67, and cleaved caspase-3 in tumor tissues.	cimo	13-17	signal transducer and activator of transcription 3	Mus musculus	131-136
25293877-5	2014	Intriguingly, lycopene chemopreventive effects in wild-type mice were associated with reduced hepatic proinflammatory signaling (phosphorylation of NK-kappaB p65 and STAT3; IL6 protein) and inflammatory foci.	Lycopene	14-22	signal transducer and activator of transcription 3	Mus musculus	166-171
25371731-9	2014	By contrast, treatment with the p38 inhibitor, SB203580, decreased the levels of p-STAT3, TNF-alpha and IL-10 (P<0.05) following LPS stimulation.	SB 203580	47-55	signal transducer and activator of transcription 3	Mus musculus	83-88
25181692-15	2014	Incubation of HCC cell lines with tocilizumab or knockdown of signal transducer and activator of transcription 3 in HCC cells reduced the ability of TAMs to promote sphere formation by CD44+ cells in culture and growth of xenograft tumors in mice.	tams	149-153	signal transducer and activator of transcription 3	Mus musculus	62-112
25043492-10	2014	Similar results are also observed in leukemia inhibitory factor (LIF)-treated astroglial cultures suggesting that miR-17-5p particularly modulates reactive astrocyte proliferation initiated by LIF presumably via the JAK/STAT3 pathway.	mir-17-5p	114-123	signal transducer and activator of transcription 3	Mus musculus	220-225
24715223-0	2014	The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.	triterpenoid TP-222	14-26	signal transducer and activator of transcription 3	Mus musculus	46-51
24715223-0	2014	The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	28-35	signal transducer and activator of transcription 3	Mus musculus	46-51
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	triterpenoid TP-222	12-24	signal transducer and activator of transcription 3	Mus musculus	111-161
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	triterpenoid TP-222	12-24	signal transducer and activator of transcription 3	Mus musculus	163-168
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole	26-85	signal transducer and activator of transcription 3	Mus musculus	111-161
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole	26-85	signal transducer and activator of transcription 3	Mus musculus	163-168
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	87-94	signal transducer and activator of transcription 3	Mus musculus	111-161
24715223-2	2014	A prototype triterpenoid, 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] imidazole (CDDO-Im), also inhibits signal transducer and activator of transcription 3 (STAT3) activation.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	87-94	signal transducer and activator of transcription 3	Mus musculus	163-168
24715223-14	2014	Colonic STAT3 activation was also significantly reduced by CDDO-Im treatment.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	59-66	signal transducer and activator of transcription 3	Mus musculus	8-13
25436606-7	2014	Conversely, sorafenib seems to act by influencing both STAT3 and ERK activity at muscle level, leading to reduced accumulation of Pax7 and atrogin-1.	Sorafenib	12-21	signal transducer and activator of transcription 3	Mus musculus	55-60
24997323-0	2014	Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling.	kurarinol	0-9	signal transducer and activator of transcription 3	Mus musculus	87-137
24997323-6	2014	In addition, kurarinol gave rise to a considerable decrease in the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) in HCC cells.	kurarinol	13-22	signal transducer and activator of transcription 3	Mus musculus	95-145
24997323-6	2014	In addition, kurarinol gave rise to a considerable decrease in the transcriptional activity of signal transducer and activator of transcription 3 (STAT3) in HCC cells.	kurarinol	13-22	signal transducer and activator of transcription 3	Mus musculus	147-152
24997323-7	2014	Suppression of STAT3 signaling is involved in kurarinol-induced HCC cell apoptosis.	kurarinol	46-55	signal transducer and activator of transcription 3	Mus musculus	15-20
24997323-9	2014	Similarly, the transcriptional activity of STAT3 in transplanted tumor tissues was significantly suppressed after kurarinol treatment.	kurarinol	114-123	signal transducer and activator of transcription 3	Mus musculus	43-48
24997323-11	2014	Suppressing STAT3 signaling is implicated in kurarinol-mediated HCC cell apoptosis.	kurarinol	45-54	signal transducer and activator of transcription 3	Mus musculus	12-17
25429137-0	2014	Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis.	Prostaglandins	136-149	signal transducer and activator of transcription 3	Mus musculus	89-94
25412315-0	2014	BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells.	Bismuth	0-3	signal transducer and activator of transcription 3	Mus musculus	80-85
25258409-10	2014	Nicotine markedly inhibited the elevation of TNF-alpha and IL-6 mRNA as well as phosphorylated signal transducer and activator of transcription (Stat) 3 expression in the colons of the tumor model mice.	Nicotine	0-8	signal transducer and activator of transcription 3	Mus musculus	95-152
25258409-12	2014	Furthermore, it is presumed that nicotine downregulates the expression of inflammatory mediators such as IL-6/Stat3 and TNF-alpha, thereby reducing the colonic tumorigenesis associated with chronic colitis.	Nicotine	33-41	signal transducer and activator of transcription 3	Mus musculus	110-115
25396421-9	2014	In addition, levels of the signaling protein phosphorylated STAT3 were higher in the nicotine group and lower in the methyllycaconitine group compared with the untreated myocarditis group.	Nicotine	85-93	signal transducer and activator of transcription 3	Mus musculus	60-65
25396421-9	2014	In addition, levels of the signaling protein phosphorylated STAT3 were higher in the nicotine group and lower in the methyllycaconitine group compared with the untreated myocarditis group.	methyllycaconitine	117-135	signal transducer and activator of transcription 3	Mus musculus	60-65
25396421-11	2014	Because nicotine is a alpha7nAchR agonist and methyllycaconitine is a alpha7nAchR antagonist, we conclude that alpha7nAchR activation increases the phosphorylation of STAT3, reduces the expression of TNF-alpha and IL-6, and, ultimately, alleviates viral myocarditis.	methyllycaconitine	46-64	signal transducer and activator of transcription 3	Mus musculus	167-172
25047252-9	2014	At the mechanistic level, CDDO-Me treatment dampened MEK-1/2, ERK, and STAT-3 signaling within lymphocytes and oxidative stress.	bardoxolone methyl	26-33	signal transducer and activator of transcription 3	Mus musculus	71-77
25301019-5	2014	Moreover, addition of L-alanine or L-serine markedly reduced the production of several cytokines including TNF-alpha induced by lipopolysaccharide (LPS) through inhibition of NF-kappaB activity or STAT3 phosphorylation in neutrophils.	Alanine	22-31	signal transducer and activator of transcription 3	Mus musculus	197-202
25301019-5	2014	Moreover, addition of L-alanine or L-serine markedly reduced the production of several cytokines including TNF-alpha induced by lipopolysaccharide (LPS) through inhibition of NF-kappaB activity or STAT3 phosphorylation in neutrophils.	Serine	35-43	signal transducer and activator of transcription 3	Mus musculus	197-202
25301089-0	2014	Small molecule 1"-acetoxychavicol acetate suppresses breast tumor metastasis by regulating the SHP-1/STAT3/MMPs signaling pathway.	1'-acetoxychavicol acetate	15-41	signal transducer and activator of transcription 3	Mus musculus	101-106
25301089-2	2014	The purpose of this study is to investigate whether the natural agent 1"-acetoxychavicol acetate (ACA), derived from the rhizomes and seeds of Languas galanga, could suppress breast cancer metastasis by targeting STAT3 signaling pathway.	1'-acetoxychavicol acetate	70-96	signal transducer and activator of transcription 3	Mus musculus	213-218
25301089-2	2014	The purpose of this study is to investigate whether the natural agent 1"-acetoxychavicol acetate (ACA), derived from the rhizomes and seeds of Languas galanga, could suppress breast cancer metastasis by targeting STAT3 signaling pathway.	Acetates	98-101	signal transducer and activator of transcription 3	Mus musculus	213-218
25073716-0	2014	Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II.	(+)-Atractylenolide	73-88	signal transducer and activator of transcription 3	Mus musculus	14-19
25347472-9	2014	In mice with chemical-induced CAC, oral administration of plant-type sphingolipids called sphingadienes increased colonic SPL levels and reduced S1P levels, STAT3 signaling, cytokine levels, and tumorigenesis, indicating that SPL prevents transformation and carcinogenesis.	Sphingolipids	69-82	signal transducer and activator of transcription 3	Mus musculus	157-162
25347472-9	2014	In mice with chemical-induced CAC, oral administration of plant-type sphingolipids called sphingadienes increased colonic SPL levels and reduced S1P levels, STAT3 signaling, cytokine levels, and tumorigenesis, indicating that SPL prevents transformation and carcinogenesis.	sphingadienes	90-103	signal transducer and activator of transcription 3	Mus musculus	157-162
24933319-4	2014	In addition, trichomide A caused G0/G1 phase arrest, suppressed the activation of AKT and STAT3, and increased the level of phosphorylated SHP2 in activated T cells in dose- and time-dependent manners.	trichomide A	13-25	signal transducer and activator of transcription 3	Mus musculus	90-95
25283994-3	2014	We show here that Stat3 regulates the formation of large lysosomal vacuoles that contain triglyceride.	Triglycerides	89-101	signal transducer and activator of transcription 3	Mus musculus	18-23
25085111-8	2014	We implicated hepatic CD11b+MC as mediators of CD80 down-modulation on HBC ex vivo via a CD11b-dependent mechanism that required cell-to-cell contact and STAT3 activity.	Methylcholanthrene	28-30	signal transducer and activator of transcription 3	Mus musculus	154-159
25200186-2	2014	Leptin-independent STAT3 activation (i.e., tyrosine(705)-phosphorylation of STAT3, pSTAT3) in the hypothalamus is hypothesized as the primary mechanism of the estrogen-induced anorexic response.	Tyrosine	43-51	signal transducer and activator of transcription 3	Mus musculus	19-24
25200186-2	2014	Leptin-independent STAT3 activation (i.e., tyrosine(705)-phosphorylation of STAT3, pSTAT3) in the hypothalamus is hypothesized as the primary mechanism of the estrogen-induced anorexic response.	Tyrosine	43-51	signal transducer and activator of transcription 3	Mus musculus	76-81
25193856-7	2014	In 42 different receptor tyrosine kinase (RTKs) array, Crizotinib also strongly inhibited the expression of activated ALK in pancreatic cancer cells, modulating its downstream mediators such as STAT3, AKT, and ERK.	Crizotinib	55-65	signal transducer and activator of transcription 3	Mus musculus	194-199
25147152-5	2014	In addition, kaempferol was found to exhibit its anticancer activity through the modulation of multiple molecular targets including p53 and STAT3, through the activation of caspases, and through the generation of ROS.	kaempferol	13-23	signal transducer and activator of transcription 3	Mus musculus	140-145
25333973-6	2014	Sorafenib lowered the expressions of immunosuppressive factors, and enhanced functions and migrations of transferred CD8+ T cells through inhibition of STAT3 and other immunosuppressive factors.	Sorafenib	0-9	signal transducer and activator of transcription 3	Mus musculus	152-157
25150294-0	2014	STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.	Serine	95-101	signal transducer and activator of transcription 3	Mus musculus	0-5
25150294-10	2014	These data document that serine-phosphorylated mitochondrial STAT3 supports neoplastic hematopoietic cell growth induced by K-Ras.	Serine	25-31	signal transducer and activator of transcription 3	Mus musculus	61-66
25275304-3	2014	Mice were exposed to a moderately damaging level of loud sound revealing the phosphorylation of STAT3 tyrosine 705 residues and nuclear localization in many cell types in the inner ear including the marginal cells of the stria vascularis, type II, III, and IV fibrocytes, spiral ganglion cells, and in the inner hair cells.	Tyrosine	102-110	signal transducer and activator of transcription 3	Mus musculus	96-101
24619454-6	2014	Moreover, in our further experiment, promoted melanoma development induced by rmIL-7 was abrogated with p-Stat3 inhibitor.	rmil-7	78-84	signal transducer and activator of transcription 3	Mus musculus	106-111
25265579-0	2014	Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappaB and STAT3 signaling.	saikosaponin D	0-14	signal transducer and activator of transcription 3	Mus musculus	97-102
25265579-0	2014	Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappaB and STAT3 signaling.	Acetaminophen	32-45	signal transducer and activator of transcription 3	Mus musculus	97-102
25265579-8	2014	Collectively, these results demonstrate that SSd protects mice from APAP-induced hepatotoxicity mainly through down-regulating NF-kappaB- and STAT3-mediated inflammatory signaling.	Acetaminophen	68-72	signal transducer and activator of transcription 3	Mus musculus	142-147
25139620-4	2014	The antitumor effect of DC derived TRAIL was further augmented by deactivation of STAT3 in tumor cells by cucurbitacin I, which makes it more susceptible to DC derived TRAIL Treatment of tumor cells with cucurbitacin I upregulates TRAIL receptor expression in addition to activation of caspases.	cucurbitacin I	106-120	signal transducer and activator of transcription 3	Mus musculus	82-87
25139620-4	2014	The antitumor effect of DC derived TRAIL was further augmented by deactivation of STAT3 in tumor cells by cucurbitacin I, which makes it more susceptible to DC derived TRAIL Treatment of tumor cells with cucurbitacin I upregulates TRAIL receptor expression in addition to activation of caspases.	cucurbitacin I	204-218	signal transducer and activator of transcription 3	Mus musculus	82-87
24619454-7	2014	The increased proportion and absolute number of IL-17-producing gammadelta27(-) cell induced by rmIL-7 were also abolished with the p-Stat3 inhibitor administration, and the suppressed melanoma development induced by anti-IL-7R antibody treatment was reversed with additional use of Ad-IL-17.	rmil-7	96-102	signal transducer and activator of transcription 3	Mus musculus	134-139
25149535-1	2014	AZD1480 is a potent, competitive small-molecule inhibitor of JAK1/2 kinase which inhibits STAT3 phosphorylation and tumor growth.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	90-95
25162585-5	2014	Moreover, 6-DG increased the ratio of phosphorylated signal transducers and activators of transcription 1 (p-STAT1)/p-STAT3 and down-regulated the gene expression of IL-1beta, IL-6, and IL-10.	6-dehydrogingerdione	10-14	signal transducer and activator of transcription 3	Mus musculus	118-123
25216522-6	2014	STAT3 inhibitors, AG 490 and piplartine (PL) induced anoikis in a concentration-dependent manner in anoikis resistant cells.	piplartine	41-43	signal transducer and activator of transcription 3	Mus musculus	0-5
25216522-7	2014	Over-expression of STAT3 or treatment with IL-6 not only increased anoikis resistance, but also protected the cancer cells from PL-induced anoikis.	piplartine	128-130	signal transducer and activator of transcription 3	Mus musculus	19-24
24983364-5	2014	Wit inhibits EGF-, PDGF-, IL-6-, IFNbeta-, and GM-CSF-stimulation of tyrosine phosphorylation of STAT3 and STAT5 but not of EGFR or PDGFR.	Tyrosine	69-77	signal transducer and activator of transcription 3	Mus musculus	97-102
24889897-3	2014	From a series of cyclometalated rhodium(III) and iridium(III) complexes, a rhodium(III) complex emerged as a potent inhibitor of STAT3 that targeted the SH2 domain and inhibited STAT3 phosphorylation and dimerization.	Iridium	49-56	signal transducer and activator of transcription 3	Mus musculus	129-134
24889897-3	2014	From a series of cyclometalated rhodium(III) and iridium(III) complexes, a rhodium(III) complex emerged as a potent inhibitor of STAT3 that targeted the SH2 domain and inhibited STAT3 phosphorylation and dimerization.	Iridium	49-56	signal transducer and activator of transcription 3	Mus musculus	178-183
25275304-7	2014	Finally, JAK2/STAT3 inhibition reduced levels of ROS detected in outer hair cells at two hours post noise exposure.	Reactive Oxygen Species	49-52	signal transducer and activator of transcription 3	Mus musculus	14-19
25232250-9	2014	In contrast, the phosphorylation of Stat3 in the liver was stronger in alcohol-treated TLR4 mutant mice compared to alcohol-treated wildtype mice.	Alcohols	71-78	signal transducer and activator of transcription 3	Mus musculus	36-41
25232250-9	2014	In contrast, the phosphorylation of Stat3 in the liver was stronger in alcohol-treated TLR4 mutant mice compared to alcohol-treated wildtype mice.	Alcohols	116-123	signal transducer and activator of transcription 3	Mus musculus	36-41
25232250-10	2014	The occupancy of hepcidin gene promoter by Stat3 was observed in alcohol-fed mutant, but not in wildtype, mice.	Alcohols	65-72	signal transducer and activator of transcription 3	Mus musculus	43-48
25232490-2	2014	Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	163-167	signal transducer and activator of transcription 3	Mus musculus	52-57
25232490-2	2014	Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively.	Tetradecanoylphorbol Acetate	168-171	signal transducer and activator of transcription 3	Mus musculus	52-57
24837470-10	2014	In addition, PL treatment impeded activation of the JAK/STAT3 signaling in splenocytes.	piperlonguminine	13-15	signal transducer and activator of transcription 3	Mus musculus	56-61
25068886-7	2014	Interestingly, sunitinib modulated tumor infiltration with bone marrow-derived cells (CD45+), recruitment of M2-like macrophages (CD163+) and activation of inflammatory pathways (phospho-STAT3) in a manner that was age-dependent.	Sunitinib	15-24	signal transducer and activator of transcription 3	Mus musculus	187-192
24903577-9	2014	We showed ANGPTL4-induced nitric oxide production through an integrin/JAK/STAT3-mediated upregulation of inducible nitric oxide synthase (iNOS) expression in wound epithelia, thus revealing a hitherto unknown mechanism by which ANGPTL4 regulated angiogenesis via keratinocyte-to-endothelial-cell communication.	Nitric Oxide	26-38	signal transducer and activator of transcription 3	Mus musculus	74-79
24992071-9	2014	DX8-treated cancer cells showed clear degradation of kinase JAK3/STAT3 protein levels.	CHEMBL577934	0-3	signal transducer and activator of transcription 3	Mus musculus	65-70
24992071-11	2014	Collectively, our results demonstrate potent anti-angiogenic, and selective JAK3/STAT3 down-regulating anticancer characteristics of DX8, a new dexamethasone-based antitumor molecule.	Dexamethasone	144-157	signal transducer and activator of transcription 3	Mus musculus	81-86
24976178-2	2014	In this study, we demonstrate that acute treatment with AMP-activated protein kinase (AMPK) agonists AICAR and metformin efficiently repressed IL-6-induced hepatic proinflammatory gene expression and activation of STAT3 in a mouse model of diet-induced type 2 diabetes, bringing it back to basal nonstimulated level.	Metformin	111-120	signal transducer and activator of transcription 3	Mus musculus	214-219
24998255-10	2014	Addition of LIF (1000 U/mL) or octreotide (1 mumol/L) in LIF-free medium significantly increased both phosphorylation and nuclear ocalization of STAT3.	Octreotide	31-41	signal transducer and activator of transcription 3	Mus musculus	145-150
24808536-8	2014	MS-275 was also effective in inhibiting STAT3 and Akt phosphorylation, but this treatment did not affect their expression levels.	entinostat	0-6	signal transducer and activator of transcription 3	Mus musculus	40-45
25098409-0	2014	TLR9 ligands induce S100A8 in macrophages via a STAT3-dependent pathway which requires IL-10 and PGE2.	Dinoprostone	97-101	signal transducer and activator of transcription 3	Mus musculus	48-53
24913968-10	2014	Neuronal differentiation of ES cells was attenuated by treatment with SP600125, which inhibited the JNK activation and decreased the activation of STAT1 and STAT3, and consequently suppressed the expressions of GAP-43, neurofilament, betaIII-tubulin, and the secretion of VEGF.	pyrazolanthrone	70-78	signal transducer and activator of transcription 3	Mus musculus	157-162
24913968-11	2014	Data from immunocytochemistry indicated that the nuclear translocation of STAT3 was reduced, and neurites of ES-derived neurons were shorter after treatment with SP600125 compared with control cells.	pyrazolanthrone	162-170	signal transducer and activator of transcription 3	Mus musculus	74-79
25156286-7	2014	Sappanchalcone blocked cell cycle progression in the G2/M phase, brazilin inhibited TNFalpha/NF-kappaB signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNFalpha/NF-kappaB signaling.	butein	120-126	signal transducer and activator of transcription 3	Mus musculus	142-147
24710718-3	2014	We hypothesized that Cav-1 could attenuate ethanol-mediated nitrosative stress and liver damage through regulating epidermal growth factor receptor/signal transducer and activator of transcription 3/inducible nitric oxide synthase (EGFR/STAT3/iNOS)-signaling cascades.	Ethanol	43-50	signal transducer and activator of transcription 3	Mus musculus	148-198
24710718-3	2014	We hypothesized that Cav-1 could attenuate ethanol-mediated nitrosative stress and liver damage through regulating epidermal growth factor receptor/signal transducer and activator of transcription 3/inducible nitric oxide synthase (EGFR/STAT3/iNOS)-signaling cascades.	Ethanol	43-50	signal transducer and activator of transcription 3	Mus musculus	237-242
24710718-6	2014	Furthermore, the results revealed that the ethanol-mediated Cav-1 increase was in an extracellular signal-regulated kinase-dependent manner, and Cav-1 protected hepatocytes from ethanol-mediated apoptosis by inhibiting iNOS activity and regulating EGFR- and STAT3-signaling cascades.	Ethanol	43-50	signal transducer and activator of transcription 3	Mus musculus	258-263
24473905-5	2014	Tyrphostin AG490 suppressed STAT3 phosphorylation and the expression of tumor necrosis factor-related apoptosis-inducing ligand and RANKL by synovial fluid cells.	Tyrphostins	0-10	signal transducer and activator of transcription 3	Mus musculus	28-33
24880019-0	2014	Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-kappaB activities.	ursolic acid	0-12	signal transducer and activator of transcription 3	Mus musculus	126-131
24219385-4	2014	Moreover, baicalin pretreatment can effectively inhibit Abeta-induced phosphorylation of JAK2 and STAT3.	baicalin	10-18	signal transducer and activator of transcription 3	Mus musculus	98-103
24582310-11	2014	Moreover, mice injected with Stattic, a STAT3 inhibitor, had a significant decrease in histamine secretion.	Histamine	87-96	signal transducer and activator of transcription 3	Mus musculus	40-45
24880019-0	2014	Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-kappaB activities.	Carbon Tetrachloride	25-45	signal transducer and activator of transcription 3	Mus musculus	126-131
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	42-44	signal transducer and activator of transcription 3	Mus musculus	120-125
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	67-69	signal transducer and activator of transcription 3	Mus musculus	120-125
24880019-10	2014	In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the STAT3 and NF-kappaB signaling pathways.	ursolic acid	91-93	signal transducer and activator of transcription 3	Mus musculus	179-184
24850910-2	2014	Here, we have observed that application of 100 nM angiotensin II (Ang II) to cultured podocytes for 6-24 hours causes a marked increase in the phosphorylation of STAT3 on tyrosine Y705 but has no effect on phosphorylation at serine S727.	Tyrosine	171-179	signal transducer and activator of transcription 3	Mus musculus	162-167
25098409-9	2014	The promoter region responsible for activation, either directly, or indirectly via IL-10 and PGE2, was located within a -178 to -34-bp region and required STAT3 binding.	Dinoprostone	93-97	signal transducer and activator of transcription 3	Mus musculus	155-160
25410603-1	2014	Hearts of mice with reduction of function mutation in STAT3 (SA/SA) develop fibrotic collagen foci and reduced systolic function with hypertension.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	61-63	signal transducer and activator of transcription 3	Mus musculus	54-59
25410603-1	2014	Hearts of mice with reduction of function mutation in STAT3 (SA/SA) develop fibrotic collagen foci and reduced systolic function with hypertension.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	64-66	signal transducer and activator of transcription 3	Mus musculus	54-59
24850910-2	2014	Here, we have observed that application of 100 nM angiotensin II (Ang II) to cultured podocytes for 6-24 hours causes a marked increase in the phosphorylation of STAT3 on tyrosine Y705 but has no effect on phosphorylation at serine S727.	Serine	225-231	signal transducer and activator of transcription 3	Mus musculus	162-167
24850910-3	2014	By contrast, Ang II treatment of short periods (20-60 minutes) caused a small but consistent suppression of tyrosine phosphylation of STAT3.	Tyrosine	108-116	signal transducer and activator of transcription 3	Mus musculus	134-139
25013518-1	2014	JSI-124, also known as cucurbitacin I, is a selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and in vitro and in vivo studies have found that it has anti-tumor and anti-proliferative properties.	cucurbitacin I	0-7	signal transducer and activator of transcription 3	Mus musculus	80-130
25013518-1	2014	JSI-124, also known as cucurbitacin I, is a selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and in vitro and in vivo studies have found that it has anti-tumor and anti-proliferative properties.	cucurbitacin I	0-7	signal transducer and activator of transcription 3	Mus musculus	136-141
25013518-1	2014	JSI-124, also known as cucurbitacin I, is a selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and in vitro and in vivo studies have found that it has anti-tumor and anti-proliferative properties.	cucurbitacin I	23-37	signal transducer and activator of transcription 3	Mus musculus	80-130
25013518-1	2014	JSI-124, also known as cucurbitacin I, is a selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3), and in vitro and in vivo studies have found that it has anti-tumor and anti-proliferative properties.	cucurbitacin I	23-37	signal transducer and activator of transcription 3	Mus musculus	136-141
25013518-10	2014	These findings show a novel role of JSI124 in tumor suppression through the downregulation of the expression of STAT3 in tumor-associated B cells.	cucurbitacin I	36-42	signal transducer and activator of transcription 3	Mus musculus	112-117
24820114-11	2014	Likewise, p,p"-DDT stimulated the JAK/STAT3 pathway in nude mice, as well as altered the mRNA levels of E-cadherin, N-cadherin, and CD29.	DDT	10-18	signal transducer and activator of transcription 3	Mus musculus	38-43
24735751-0	2014	A sorafenib derivative and novel SHP-1 agonist, SC-59, acts synergistically with radiotherapy in hepatocellular carcinoma cells through inhibition of STAT3.	Sorafenib	2-11	signal transducer and activator of transcription 3	Mus musculus	150-155
24735751-11	2014	Moreover, SC-59 significantly synergized radiotherapy in a Huh7 xenograft model by targeting SHP-1/STAT3 signaling.	sc-59	10-15	signal transducer and activator of transcription 3	Mus musculus	99-104
24520814-0	2014	Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway.	SCHEMBL6784264	26-64	signal transducer and activator of transcription 3	Mus musculus	99-104
25025494-5	2014	Here we show that multiple mechanistically distinct mouse models of neurotoxicity (MPTP, AMP, METH, MDA, MDMA, KA, TMT) engender the same neuroinflammatory and STAT3 activation responses in specific regions of the brain targeted by each neurotoxicant.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	83-87	signal transducer and activator of transcription 3	Mus musculus	160-165
25025494-5	2014	Here we show that multiple mechanistically distinct mouse models of neurotoxicity (MPTP, AMP, METH, MDA, MDMA, KA, TMT) engender the same neuroinflammatory and STAT3 activation responses in specific regions of the brain targeted by each neurotoxicant.	Adenosine Monophosphate	89-92	signal transducer and activator of transcription 3	Mus musculus	160-165
25025494-8	2014	Selective deletion of STAT3 from astrocytes in STAT3 conditional knockout mice markedly attenuated MPTP-induced astrogliosis.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	99-103	signal transducer and activator of transcription 3	Mus musculus	22-27
25025494-8	2014	Selective deletion of STAT3 from astrocytes in STAT3 conditional knockout mice markedly attenuated MPTP-induced astrogliosis.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	99-103	signal transducer and activator of transcription 3	Mus musculus	47-52
24985096-0	2014	Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-kappaB activation in cultured astrocytes and microglial BV-2 cells.	sauchinone	25-35	signal transducer and activator of transcription 3	Mus musculus	73-78
24985096-9	2014	The binding of ent-Sauchinone to STAT3 was evaluated by a pull-down assay and by a docking model using Autodock VINA software (Hoover"s Inc., Texas, United states).	sauchinone	19-29	signal transducer and activator of transcription 3	Mus musculus	33-38
24985096-12	2014	NF- kappaB amyloid and STAT3, critical transcriptional factors regulating not only inflammation but also amyloidogenesis, were also inhibited in a concentration dependent manner by ent-Sauchinone by blocking the phosphorylation of I kappaB and STAT3 in cultured astrocytes and microglial BV-2 cells.	sauchinone	185-195	signal transducer and activator of transcription 3	Mus musculus	23-28
24985096-12	2014	NF- kappaB amyloid and STAT3, critical transcriptional factors regulating not only inflammation but also amyloidogenesis, were also inhibited in a concentration dependent manner by ent-Sauchinone by blocking the phosphorylation of I kappaB and STAT3 in cultured astrocytes and microglial BV-2 cells.	sauchinone	185-195	signal transducer and activator of transcription 3	Mus musculus	244-249
24985096-13	2014	The docking model approach showed that ent-Sauchinone binds to STAT3, and the employment of a STAT3 inhibitor and siRNA reversed ent-Sauchinone-induced inhibition NF-kappaB activation and Abeta generation.	sauchinone	43-53	signal transducer and activator of transcription 3	Mus musculus	63-68
24985096-13	2014	The docking model approach showed that ent-Sauchinone binds to STAT3, and the employment of a STAT3 inhibitor and siRNA reversed ent-Sauchinone-induced inhibition NF-kappaB activation and Abeta generation.	sauchinone	43-53	signal transducer and activator of transcription 3	Mus musculus	94-99
24985096-13	2014	The docking model approach showed that ent-Sauchinone binds to STAT3, and the employment of a STAT3 inhibitor and siRNA reversed ent-Sauchinone-induced inhibition NF-kappaB activation and Abeta generation.	sauchinone	133-143	signal transducer and activator of transcription 3	Mus musculus	63-68
24985096-13	2014	The docking model approach showed that ent-Sauchinone binds to STAT3, and the employment of a STAT3 inhibitor and siRNA reversed ent-Sauchinone-induced inhibition NF-kappaB activation and Abeta generation.	sauchinone	133-143	signal transducer and activator of transcription 3	Mus musculus	94-99
24985096-14	2014	CONCLUSIONS: These results indicated that ent-Sauchinone inhibited neuroinflammation and amyloidogenesis through the inhibition of STAT3-mediated NF-kappaB activity, and thus could be applied in the treatment of neuro-inflammatory diseases, including Alzheimer"s disease.	sauchinone	46-56	signal transducer and activator of transcription 3	Mus musculus	131-136
25081318-0	2014	Axitinib augments antitumor activity in renal cell carcinoma via STAT3-dependent reversal of myeloid-derived suppressor cell accumulation.	Axitinib	0-8	signal transducer and activator of transcription 3	Mus musculus	65-70
25081318-5	2014	These results suggest that axitinib has the potential to modulate antitumor immunity by downregulating STAT3 expression and reversing MDSC-mediated tumor-induced immunosuppression.	Axitinib	27-35	signal transducer and activator of transcription 3	Mus musculus	103-108
24682898-6	2014	CNTF treatment prevented reduced STAT3 phosphorylation (Tyr 705) in DRG of STZ-diabetic mice and also enhanced STAT3 phosphorylation in rat DRG cultures.	Streptozocin	75-78	signal transducer and activator of transcription 3	Mus musculus	33-38
24608443-6	2014	Inhibition of AGE formation in db/db mice by pyridoxamine treatment attenuated proteinuria and podocyte injury, restored SIRT1 expression, and reduced p65 and STAT3 acetylation.	Pyridoxamine	45-57	signal transducer and activator of transcription 3	Mus musculus	159-164
24608443-8	2014	Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury.	MS417	99-104	signal transducer and activator of transcription 3	Mus musculus	163-168
24492981-8	2014	In agreement with these findings, hepatic activation of the major IL-6 downstream signaling molecule signal transducer and activator of transcription 3 (STAT3) was higher in ethanol-fed ALDH2(-/-) mice than in wild-type mice.	Ethanol	174-181	signal transducer and activator of transcription 3	Mus musculus	101-151
24492981-8	2014	In agreement with these findings, hepatic activation of the major IL-6 downstream signaling molecule signal transducer and activator of transcription 3 (STAT3) was higher in ethanol-fed ALDH2(-/-) mice than in wild-type mice.	Ethanol	174-181	signal transducer and activator of transcription 3	Mus musculus	153-158
24819716-3	2014	FLLL31 is a newly developed compound based on the herbal medicine curcumin, which specifically suppresses the activation of STAT3.	FLLL 31	0-6	signal transducer and activator of transcription 3	Mus musculus	124-129
24819716-3	2014	FLLL31 is a newly developed compound based on the herbal medicine curcumin, which specifically suppresses the activation of STAT3.	Curcumin	66-74	signal transducer and activator of transcription 3	Mus musculus	124-129
24820265-0	2014	Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line.	Temozolomide	65-77	signal transducer and activator of transcription 3	Mus musculus	14-19
24727615-6	2014	Furthermore, we identified signal transducer and activator of transcription 3 (STAT3) as the transcription factor responsible for p27-regulated MnSOD expression, which was further mediated by ERK- and ATF1-dependent transactivation of the cAMP response element (CRE) within the Stat3 promoter.	Cyclic AMP	239-243	signal transducer and activator of transcription 3	Mus musculus	27-77
24727615-6	2014	Furthermore, we identified signal transducer and activator of transcription 3 (STAT3) as the transcription factor responsible for p27-regulated MnSOD expression, which was further mediated by ERK- and ATF1-dependent transactivation of the cAMP response element (CRE) within the Stat3 promoter.	Cyclic AMP	239-243	signal transducer and activator of transcription 3	Mus musculus	79-84
24727615-6	2014	Furthermore, we identified signal transducer and activator of transcription 3 (STAT3) as the transcription factor responsible for p27-regulated MnSOD expression, which was further mediated by ERK- and ATF1-dependent transactivation of the cAMP response element (CRE) within the Stat3 promoter.	Cyclic AMP	239-243	signal transducer and activator of transcription 3	Mus musculus	278-283
24657398-7	2014	RESULTS: Nintedanib induced anti-proliferation in HCC cell lines by targeting STAT3.	nintedanib	9-19	signal transducer and activator of transcription 3	Mus musculus	78-83
24657398-8	2014	Ectopic STAT3 abolished nintedanib-mediated apoptosis in HCC cells.	nintedanib	24-34	signal transducer and activator of transcription 3	Mus musculus	8-13
24657398-9	2014	Nintedanib further activated SHP-1 in purified SHP-1 proteins suggesting that nintedanib directly affects SHP-1 for STAT3 inhibition.	nintedanib	0-10	signal transducer and activator of transcription 3	Mus musculus	116-121
24657398-9	2014	Nintedanib further activated SHP-1 in purified SHP-1 proteins suggesting that nintedanib directly affects SHP-1 for STAT3 inhibition.	nintedanib	78-88	signal transducer and activator of transcription 3	Mus musculus	116-121
24819473-0	2014	Biologically active leptin-related synthetic peptides activate STAT3 via phosphorylation of ERK1/2 and PI-3K.	Peptides	45-53	signal transducer and activator of transcription 3	Mus musculus	63-68
24731292-11	2014	Distribution of Stat3 activation is altered in DSS-treated Epim(-/-) mice.	dss	47-50	signal transducer and activator of transcription 3	Mus musculus	16-21
24731292-12	2014	Our findings support the notion that myofibroblasts modulate IL-6/p-Stat3 signaling in DSS-treated Epim(-/-) mice.	dss	87-90	signal transducer and activator of transcription 3	Mus musculus	68-73
24476004-8	2014	A diethylnitrosamine (DEN)-induced HCC mouse model was assessed with or without injection of NSC 74859, a STAT3 inhibitor, to show accompanied changes among the expressions of STAT3, SOCS3, c-myc, MMP-2, and MMP-9.	Diethylnitrosamine	2-20	signal transducer and activator of transcription 3	Mus musculus	176-181
24476004-8	2014	A diethylnitrosamine (DEN)-induced HCC mouse model was assessed with or without injection of NSC 74859, a STAT3 inhibitor, to show accompanied changes among the expressions of STAT3, SOCS3, c-myc, MMP-2, and MMP-9.	Diethylnitrosamine	22-25	signal transducer and activator of transcription 3	Mus musculus	176-181
24819685-0	2014	Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors.	opb-31121	83-92	signal transducer and activator of transcription 3	Mus musculus	67-72
24812279-7	2014	p53 inhibition blocked transient DOX-induced STAT3 activation in MHC-CB7 mice, which was associated with enhanced induction of the DNA repair proteins Ku70 and Ku80.	Doxorubicin	33-36	signal transducer and activator of transcription 3	Mus musculus	45-50
24812279-8	2014	Mice with cardiomyocyte-restricted deletion of STAT3 exhibited worse cardiac function, higher levels of cardiomyocyte apoptosis, and a greater induction of Ku70 and Ku80 in response to DOX treatment during the acute stage when compared with control animals.	Doxorubicin	185-188	signal transducer and activator of transcription 3	Mus musculus	47-52
24812279-9	2014	CONCLUSION: These data support a model wherein a p53-dependent cardioprotective pathway, mediated via STAT3 activation, mitigates DOX-induced myocardial stress during drug delivery.	Doxorubicin	130-133	signal transducer and activator of transcription 3	Mus musculus	102-107
24797626-4	2014	Ethanol programmed these neurons such that the adult expression of Pomc, Stat3, Sirt, and Asb4 gene transcripts became arrhythmic.	Ethanol	0-7	signal transducer and activator of transcription 3	Mus musculus	73-78
24922005-7	2014	Tyrosine phosphorylation status of STAT3 did not correlate with tumor IL-6 levels.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	35-40
24922005-8	2014	Serine phosphorylation of STAT3 was correlated with KRAS mutation status.	Serine	0-6	signal transducer and activator of transcription 3	Mus musculus	26-31
24819473-5	2014	OB3 also induced activation of STAT3 via phosphorylation of ERK1/2, STAT3 Ser-727, STAT3 Tyr-705 and PI-3K p85, but to a lesser degree.	Serine	74-77	signal transducer and activator of transcription 3	Mus musculus	31-36
24819473-5	2014	OB3 also induced activation of STAT3 via phosphorylation of ERK1/2, STAT3 Ser-727, STAT3 Tyr-705 and PI-3K p85, but to a lesser degree.	Serine	74-77	signal transducer and activator of transcription 3	Mus musculus	68-73
24819473-5	2014	OB3 also induced activation of STAT3 via phosphorylation of ERK1/2, STAT3 Ser-727, STAT3 Tyr-705 and PI-3K p85, but to a lesser degree.	Serine	74-77	signal transducer and activator of transcription 3	Mus musculus	68-73
24819473-5	2014	OB3 also induced activation of STAT3 via phosphorylation of ERK1/2, STAT3 Ser-727, STAT3 Tyr-705 and PI-3K p85, but to a lesser degree.	Tyrosine	89-92	signal transducer and activator of transcription 3	Mus musculus	31-36
24819473-6	2014	Using PD98059 and LY294002, specific inhibitors of MEK and PI-3K, respectively, we were able to identify the signal transduction pathways involved in peptide-induced STAT3 activation.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	6-13	signal transducer and activator of transcription 3	Mus musculus	166-171
24819473-6	2014	Using PD98059 and LY294002, specific inhibitors of MEK and PI-3K, respectively, we were able to identify the signal transduction pathways involved in peptide-induced STAT3 activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	18-26	signal transducer and activator of transcription 3	Mus musculus	166-171
24819473-7	2014	[d-Leu-4]-OB3 induced serine phosphorylation of STAT3 primarily through activation of ERK1/2.	Serine	22-28	signal transducer and activator of transcription 3	Mus musculus	48-53
24819473-8	2014	Tyrosine phosphorylation of STAT3, however, was induced primarily through activation of PI-3K.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	28-33
24819473-11	2014	In summary, we have shown for the first time that, similar to leptin, bioactive leptin-related synthetic peptide analogs activate STAT3 via phosphorylation of serine and tyrosine residues by multiple signal transduction pathways.	Serine	159-165	signal transducer and activator of transcription 3	Mus musculus	130-135
24819473-11	2014	In summary, we have shown for the first time that, similar to leptin, bioactive leptin-related synthetic peptide analogs activate STAT3 via phosphorylation of serine and tyrosine residues by multiple signal transduction pathways.	Tyrosine	170-178	signal transducer and activator of transcription 3	Mus musculus	130-135
24945311-0	2014	Celecoxib suppresses the phosphorylation of STAT3 protein and can enhance the radiosensitivity of medulloblastoma-derived cancer stem-like cells.	Celecoxib	0-9	signal transducer and activator of transcription 3	Mus musculus	44-49
24945311-4	2014	Celecoxib, a selective COX-2 inhibitor, has been shown to potentially reduce STAT3 phosphorylation.	Celecoxib	0-9	signal transducer and activator of transcription 3	Mus musculus	77-82
24582615-0	2014	Swertiamarin attenuates inflammation mediators via modulating NF-kappaB/I kappaB and JAK2/STAT3 transcription factors in adjuvant induced arthritis.	swertiamarin	0-12	signal transducer and activator of transcription 3	Mus musculus	90-95
24582615-8	2014	The swertiamarin treatment significantly (P<=0.05) inhibited the release of NF-kappaB p65, p-IkappaBalpha, p-JAK2 and p-STAT3 signaling proteins levels on both experimental animals and LPS induced cells.	swertiamarin	4-16	signal transducer and activator of transcription 3	Mus musculus	123-128
24582615-11	2014	Thus the swertiamarin inhibited the development of arthritis by modulating NF-kappaB/IkappaB and JAK2/STAT3 signaling.	swertiamarin	9-21	signal transducer and activator of transcription 3	Mus musculus	102-107
24887420-3	2014	GSNO treatment abrogated growth factor (HB-EGF) induced signal transduction including phosphorylation of Akt, p42/44 and STAT3, which are known to play critical roles in ovarian cancer growth and progression.	S-Nitrosoglutathione	0-4	signal transducer and activator of transcription 3	Mus musculus	121-126
24887420-8	2014	As a novel finding, we observed that GSNO also induced nitrosylation with inverse relationship at tyrosine 705 phosphorylation of STAT3, an established player in chemoresistance and cell proliferation in ovarian cancer and in cancer in general.	S-Nitrosoglutathione	37-41	signal transducer and activator of transcription 3	Mus musculus	130-135
24887420-8	2014	As a novel finding, we observed that GSNO also induced nitrosylation with inverse relationship at tyrosine 705 phosphorylation of STAT3, an established player in chemoresistance and cell proliferation in ovarian cancer and in cancer in general.	Tyrosine	98-106	signal transducer and activator of transcription 3	Mus musculus	130-135
24520814-8	2014	A pull-down assay showed that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal interfered with binding of ATP to STAT3.	SCHEMBL6784264	30-68	signal transducer and activator of transcription 3	Mus musculus	103-108
24520814-8	2014	A pull-down assay showed that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal interfered with binding of ATP to STAT3.	Adenosine Triphosphate	96-99	signal transducer and activator of transcription 3	Mus musculus	103-108
24520814-9	2014	Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner.	SCHEMBL6784264	31-69	signal transducer and activator of transcription 3	Mus musculus	108-113
24520814-9	2014	Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner.	SCHEMBL6784264	31-69	signal transducer and activator of transcription 3	Mus musculus	149-154
24520814-9	2014	Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner.	Adenosine Triphosphate	134-137	signal transducer and activator of transcription 3	Mus musculus	108-113
24520814-9	2014	Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner.	Adenosine Triphosphate	134-137	signal transducer and activator of transcription 3	Mus musculus	149-154
24520814-10	2014	CONCLUSIONS AND IMPLICATIONS: (E)-2,4-bis(p-hydroxyphenyl)-2-butenal exerted anti-inflammatory and anti-arthritic effects through inhibition of the NF-kappaB/STAT3 pathway by direct binding to STAT3.	SCHEMBL6784264	30-68	signal transducer and activator of transcription 3	Mus musculus	158-163
24520814-10	2014	CONCLUSIONS AND IMPLICATIONS: (E)-2,4-bis(p-hydroxyphenyl)-2-butenal exerted anti-inflammatory and anti-arthritic effects through inhibition of the NF-kappaB/STAT3 pathway by direct binding to STAT3.	SCHEMBL6784264	30-68	signal transducer and activator of transcription 3	Mus musculus	193-198
24445959-6	2014	Meanwhile, AG490 (a specific inhibitor of the JAK2/STAT3 signaling pathway) and JAK2 siRNA were used to manipulate JAK2/STAT3 activity.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	11-16	signal transducer and activator of transcription 3	Mus musculus	120-125
24520814-5	2014	Binding of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal to STAT3 was evaluated by a pull-down assay and its binding site was predicted using molecular docking studies with Autodock VINA.	SCHEMBL6784264	11-49	signal transducer and activator of transcription 3	Mus musculus	53-58
24680937-0	2014	Diosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in mice.	Diosmin	0-7	signal transducer and activator of transcription 3	Mus musculus	86-91
24631338-3	2014	We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-kappaB and STAT3.	tricin 4'-O-(threo-beta-guaiacylglyceryl) ether	21-25	signal transducer and activator of transcription 3	Mus musculus	215-220
25011972-0	2014	[Effect of curcumin on the expression of p-STAT3 and IkappaB in db/db mice].	Curcumin	11-19	signal transducer and activator of transcription 3	Mus musculus	43-48
25011972-10	2014	Compared with the db/db mice, curcumin significantly decreased the urinary albumin, inhibited the phosphorylation of STAT3 and the degradation of IkappaB, and reduced the expression of collagen IV and FN in the kidney.	Curcumin	30-38	signal transducer and activator of transcription 3	Mus musculus	117-122
25011972-11	2014	CONCLUSION: Curcumin can obviously decrease albuminuria and attenuate glomerular sclerosis in diabetic db/db mice by inhibiting phosphorylation of STAT3 and degradation of IkappaB.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	147-152
24631338-3	2014	We demonstrated that TTGE significantly inhibited LPS-induced NO and ROS generation in RAW264.7 cells, which was correlated with the down-regulating effect of TTGE on the iNOS and COX-2 expression via NF-kappaB and STAT3.	tricin 4'-O-(threo-beta-guaiacylglyceryl) ether	159-163	signal transducer and activator of transcription 3	Mus musculus	215-220
24631338-5	2014	TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-kappaB and STAT3, which could explain the reduced TPA-induced edema symptoms.	tricin 4'-O-(threo-beta-guaiacylglyceryl) ether	0-4	signal transducer and activator of transcription 3	Mus musculus	85-90
24690200-0	2014	Hydroxy-safflor yellow A attenuates Abeta1-42-induced inflammation by modulating the JAK2/STAT3/NF-kappaB pathway.	hydroxysafflor yellow A	0-24	signal transducer and activator of transcription 3	Mus musculus	90-95
24631338-5	2014	TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-kappaB and STAT3, which could explain the reduced TPA-induced edema symptoms.	Tetradecanoylphorbol Acetate	124-127	signal transducer and activator of transcription 3	Mus musculus	85-90
24607417-5	2014	Coptisine significantly impeded osteosarcoma cell migration, invasion, and capillary-like network formation by decreasing the expression of VE-cadherin and integrin ss3, and diminishing STAT3 phosphorylation.	coptisine	0-9	signal transducer and activator of transcription 3	Mus musculus	186-191
24690200-13	2014	Pharmacological inhibition of STAT3 by AG490 reversed the inactivation of p65 and anti-inflammatory effects of HSYA.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	39-44	signal transducer and activator of transcription 3	Mus musculus	30-35
24598351-12	2014	Among the predicted targets, we discovered that a signal transducer and activator of transcription 3 (STAT3) was particularly up-regulated beginning during the early phase of HAL-induced liver injury.	Halothane	175-178	signal transducer and activator of transcription 3	Mus musculus	50-100
24598351-12	2014	Among the predicted targets, we discovered that a signal transducer and activator of transcription 3 (STAT3) was particularly up-regulated beginning during the early phase of HAL-induced liver injury.	Halothane	175-178	signal transducer and activator of transcription 3	Mus musculus	102-107
24598351-13	2014	Collectively, the suppressed miR-106b expression, as well as the subsequent up-regulation of STAT3, was critical for the pathogenesis of HAL-induced liver injury.	Halothane	137-140	signal transducer and activator of transcription 3	Mus musculus	93-98
24470226-5	2014	RESULTS: LiCl treatment resulted in decreased catabolic marker messenger RNA levels and activation of NF-kappaB, p38 MAPK, and STAT-3 signaling in IL-1beta-treated articular chondrocytes.	Lithium Chloride	9-13	signal transducer and activator of transcription 3	Mus musculus	127-133
24470226-6	2014	Furthermore, LiCl directly inhibited IL-6-stimulated activation of STAT-3 signaling.	Lithium Chloride	13-17	signal transducer and activator of transcription 3	Mus musculus	67-73
24470226-8	2014	CONCLUSION: LiCl reduced catabolic events in IL-1beta-treated human articular chondrocytes and attenuated the severity of cartilage destruction in IL-1beta-treated mouse femoral head explants and in the knee joints of mice with surgically induced OA, acting via inhibition of the activities of the NF-kappaB, p38, and STAT-3 signaling pathways.	Lithium Chloride	12-16	signal transducer and activator of transcription 3	Mus musculus	318-324
24704822-17	2014	This occurs before ETBF-induced mucosal permeability, suggesting that ETBF, likely through B. fragilis toxin and its action on the colonic epithelial cell, triggers mucosal immune cell Stat3 activation.	etbf	70-74	signal transducer and activator of transcription 3	Mus musculus	185-190
24782183-9	2014	These effects of halofuginone on Th17 differentiation involved increased signaling of ERK and reduction of STAT-3 and NF-ATc1 expression.	halofuginone	17-29	signal transducer and activator of transcription 3	Mus musculus	107-113
24222636-7	2014	Furthermore, the STAT3 activation levels significantly depended on the number of motifs rather than the distance from the JAK-binding region to the tyrosine motif.	Tyrosine	148-156	signal transducer and activator of transcription 3	Mus musculus	17-22
24704822-19	2014	ETBF induces long-lived, focal colonic Stat3 activation and Th17 immune responses dependent on the ongoing ETBF colonization.	etbf	0-4	signal transducer and activator of transcription 3	Mus musculus	39-44
24688026-0	2014	JAK2-STAT3 blockade by AG490 suppresses autoimmune arthritis in mice via reciprocal regulation of regulatory T Cells and Th17 cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	23-28	signal transducer and activator of transcription 3	Mus musculus	5-10
24688026-10	2014	Numbers of p-STAT3(+) CD4(+) T cells and p-STAT5(+) CD4(+) T cells were reduced and elevated, respectively, after treatment with AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	129-134	signal transducer and activator of transcription 3	Mus musculus	13-18
24744378-5	2014	lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1.	Tyrosine	89-97	signal transducer and activator of transcription 3	Mus musculus	25-30
24446229-7	2014	Furthermore, nontoxic levels of PA promoted astrocytogenesis in the differentiated NSCs, associated with Stat3 activation and altered expression of serial of basic helix-loop-helix transcription factor genes.	Palmitic Acid	32-34	signal transducer and activator of transcription 3	Mus musculus	105-110
24302476-0	2014	STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	0-5
24302476-1	2014	STAT3 can be transcriptionally activated by phosphorylation of its tyrosine 705 or serine 727 residue.	Tyrosine	67-75	signal transducer and activator of transcription 3	Mus musculus	0-5
24302476-1	2014	STAT3 can be transcriptionally activated by phosphorylation of its tyrosine 705 or serine 727 residue.	Serine	83-89	signal transducer and activator of transcription 3	Mus musculus	0-5
24789104-9	2014	Furthermore, we found that blockade of STAT3 phosphorylation might be the underlying mechanism of metformin inhibition of IL-6-induced EMT.	Metformin	98-107	signal transducer and activator of transcription 3	Mus musculus	39-44
24789104-11	2014	We found that metformin could inhibit IL-6-induced EMT possibly by blocking STAT3 phosphorylation.	Metformin	14-23	signal transducer and activator of transcription 3	Mus musculus	76-81
24744378-5	2014	lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1.	Tyrosine	89-97	signal transducer and activator of transcription 3	Mus musculus	64-69
24744378-5	2014	lnc-DC bound directly to STAT3 in the cytoplasm, which promoted STAT3 phosphorylation on tyrosine-705 by preventing STAT3 binding to and dephosphorylation by SHP1.	Tyrosine	89-97	signal transducer and activator of transcription 3	Mus musculus	64-69
24534490-10	2014	In conclusion, azithromycin significantly attenuated P. intermedia LPS-induced production of IL-6 in murine macrophages via inhibition of NF-kappaB, STAT1 and STAT3 activation, which is possibly related to the activation of SOCS1 signaling.	Azithromycin	15-27	signal transducer and activator of transcription 3	Mus musculus	159-164
24782986-7	2014	At the molecular level, mouse tumors remaining after paclitaxel administration showed a significant increase in the expression of Oct4 and CD117 coinciding with a significant activation of the JAK2/STAT3 pathway compared to control tumors.	Paclitaxel	53-63	signal transducer and activator of transcription 3	Mus musculus	198-203
24732911-5	2014	Based on systems analysis, we observed that Zn deficiency enhances the acute phase response and particularly the JAK-STAT3 pathway, resulting in increased serum amyloid A production.	Zinc	44-46	signal transducer and activator of transcription 3	Mus musculus	117-122
24732911-7	2014	In contrast, Zn inhibited STAT3 activation through the up-regulation of SHP1 activity.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	26-31
24732911-8	2014	Collectively, these findings demonstrate that Zn deficiency enhances the acute phase response through up-regulation of the JAK-STAT3 pathway, thereby perpetuating increased inflammation that may lead to increased morbidity and mortality in response to sepsis.	Zinc	46-48	signal transducer and activator of transcription 3	Mus musculus	127-132
24782986-8	2014	The addition of CYT387 with paclitaxel resulted in the suppression of JAK2/STAT3 activation and abrogation of Oct4 and CD117 expression in mouse xenografts.	Paclitaxel	28-38	signal transducer and activator of transcription 3	Mus musculus	75-80
24534490-8	2014	Azithromycin inhibited P. intermedia LPS-induced STAT1 and STAT3 phosphorylation.	Azithromycin	0-12	signal transducer and activator of transcription 3	Mus musculus	59-64
24508558-0	2014	SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.	Methamphetamine	46-61	signal transducer and activator of transcription 3	Mus musculus	130-135
24697696-6	2014	In addition, we also demonstrated the effect of SOCS3 in prime hepatocyte by overexpression or interference of SOCS3 along with SD1008, which is a specific inhibitor of the JAK2/STAT3 signaling pathway.	8-benzyl-4-oxo-8-azabicyclo(3.2.1)oct-2-ene-6,7-dicarboxylic acid	128-134	signal transducer and activator of transcription 3	Mus musculus	178-183
24508558-7	2014	This is the first report that similar to other neurotoxicants that induce astrogliosis through the activation of JAK2/STAT3 signaling by stimulating gp-130-linked cytokine signaling resulting from neuroinflammation, METH treatment also increases astrocytic oncostatin m receptor (OSMR) expression and the phosphorylation of STAT3 (Tyr-705) in vivo.	Methamphetamine	216-220	signal transducer and activator of transcription 3	Mus musculus	118-123
24508558-7	2014	This is the first report that similar to other neurotoxicants that induce astrogliosis through the activation of JAK2/STAT3 signaling by stimulating gp-130-linked cytokine signaling resulting from neuroinflammation, METH treatment also increases astrocytic oncostatin m receptor (OSMR) expression and the phosphorylation of STAT3 (Tyr-705) in vivo.	Tyrosine	331-334	signal transducer and activator of transcription 3	Mus musculus	118-123
24508558-8	2014	Pretreatment with SN79 blocked METH-induced increases in OSMR, STAT3 phosphorylation and astrocyte activation within the striatum.	sn79	18-22	signal transducer and activator of transcription 3	Mus musculus	63-68
24508558-8	2014	Pretreatment with SN79 blocked METH-induced increases in OSMR, STAT3 phosphorylation and astrocyte activation within the striatum.	Methamphetamine	31-35	signal transducer and activator of transcription 3	Mus musculus	63-68
23891616-0	2014	Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells.	2,4-bis(4-hydroxyphenyl)-2-butenal diacetate	23-67	signal transducer and activator of transcription 3	Mus musculus	128-133
24421048-15	2014	Therefore, acute alcohol intoxication leads to decreased MRSA clearance in part by inhibiting IL-6/STAT3 induction of the antimicrobial protein Reg3gamma in the pulmonary epithelium.	Alcohols	17-24	signal transducer and activator of transcription 3	Mus musculus	99-104
24757144-0	2014	STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis.	STA-21	0-6	signal transducer and activator of transcription 3	Mus musculus	20-26
24757144-1	2014	OBJECTIVE: To investigate the impact of STA-21, a promising STAT-3 inhibitor, on the development and progression of inflammatory arthritis and to determine the possible mechanisms by which STA-21 has antiarthritic effects in interleukin-1 receptor antagonist-knockout (IL-1Ra-KO) mice, an animal model of rheumatoid arthritis (RA).	STA-21	40-46	signal transducer and activator of transcription 3	Mus musculus	60-66
24655440-3	2014	Here we report, garcinol, a polyisoprenylated benzophenone, could suppress STAT3 activation in HCC cell lines and in xenografted tumor of HCC in nude mice model.	garcinol	16-24	signal transducer and activator of transcription 3	Mus musculus	75-80
24375083-6	2014	RESULTS: In total, ~81% of the gene expression changes were altered in response to reoxygenation with 60 or 100% O2 and constituted many inflammatory-responsive genes (i.e., C5ar2, Stat3, and Ccl12).	Oxygen	113-115	signal transducer and activator of transcription 3	Mus musculus	181-186
24316441-3	2014	In this study, we demonstrated that curcumin, a natural product which functions as an anti-inflammatory agent, inhibited the activation of signal transducer and activator of transcription-3 and NF-kappa B in the injured spinal cord.	Curcumin	36-44	signal transducer and activator of transcription 3	Mus musculus	139-189
24655440-11	2014	Remarkably, garcinol inhibited the growth of human HCC xenograft tumors in athymic nu/nu mice, through the inhibition of STAT3 activation.	garcinol	12-20	signal transducer and activator of transcription 3	Mus musculus	121-126
24558360-0	2014	EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1alpha with Th17/Treg control.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	54-59
24558360-5	2014	The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG.	epigallocatechin gallate	178-182	signal transducer and activator of transcription 3	Mus musculus	79-84
24558360-5	2014	The expression of pro-inflammatory cytokines, oxidative stress proteins, and p-STAT3 (Y705) and p-STAT3 (S727), mTOR and HIF-1alpha were significantly lower in mice treated with EGCG.	epigallocatechin gallate	178-182	signal transducer and activator of transcription 3	Mus musculus	98-103
24558360-8	2014	In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG.	epigallocatechin gallate	106-110	signal transducer and activator of transcription 3	Mus musculus	12-17
24558360-8	2014	In vitro, p-STAT3 (Y705) and p-STAT3 (S727), HIF1alpha and glycolytic pathway molecules were decreased by EGCG.	epigallocatechin gallate	106-110	signal transducer and activator of transcription 3	Mus musculus	31-36
24645646-14	2014	Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei.	Curcumin	10-18	signal transducer and activator of transcription 3	Mus musculus	95-100
24645646-14	2014	Moreover, curcumin significantly reduced the expression of NF-kappaB p65 in nuclei and phospho-STAT3 (p-STAT3) in cytosols and nuclei.	Curcumin	10-18	signal transducer and activator of transcription 3	Mus musculus	104-109
24645646-15	2014	CONCLUSIONS: This study indicates that curcumin ameliorates the depressed MFG-E8 expression and the attenuated phagocytic ability of EMF-exposed N9 cells, which is attributable to the inhibition of the pro-inflammatory response through the NF-kappaB and STAT3 pathways.	Curcumin	39-47	signal transducer and activator of transcription 3	Mus musculus	254-259
24395569-0	2014	Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects.	Oligonucleotides	101-116	signal transducer and activator of transcription 3	Mus musculus	36-86
24395569-0	2014	Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects.	Oligonucleotides	101-116	signal transducer and activator of transcription 3	Mus musculus	88-93
24395569-2	2014	Intravenous delivery of a chemically modified cyclic STAT3 decoy oligonucleotide with improved serum and thermal stability demonstrated antitumor efficacy in conjunction with downmodulation of STAT3 target gene expression such as cyclin D1 and Bcl-X(L) in a mouse model of head and neck squamous cell carcinoma.	Oligonucleotides	65-80	signal transducer and activator of transcription 3	Mus musculus	53-58
24395569-2	2014	Intravenous delivery of a chemically modified cyclic STAT3 decoy oligonucleotide with improved serum and thermal stability demonstrated antitumor efficacy in conjunction with downmodulation of STAT3 target gene expression such as cyclin D1 and Bcl-X(L) in a mouse model of head and neck squamous cell carcinoma.	Oligonucleotides	65-80	signal transducer and activator of transcription 3	Mus musculus	193-198
24395569-9	2014	These findings suggest a lack of toxicity of intravenous administration of a cyclic STAT3 decoy oligonucleotide.	Oligonucleotides	96-111	signal transducer and activator of transcription 3	Mus musculus	84-89
24486434-9	2014	Taken together, our findings indicate NRPTK signaling pathways including Syk/NF-kappaB and Jak2/Stat3 cascades are potential anti-neuroinflammatory targets in microglia, and may also set the basis for the use of sesquiterpene dimmer as a therapeutic approach for neuroinflammation via interruption of these pathways.	Sesquiterpenes	212-225	signal transducer and activator of transcription 3	Mus musculus	96-101
24458145-8	2014	After 100% O2 treatment, genes involved in inflammation (Ccl12), angiogenesis (Igfr1, Stat3), and metabolism (Hk2) were upregulated.	Oxygen	11-13	signal transducer and activator of transcription 3	Mus musculus	86-91
24286865-2	2014	As triggers in disease frequently include combined increases in inflammatory cytokine and reactive oxygen species levels, we report here how oxidative stress impacts on cytokine-driven STAT3 signal transduction events.	Reactive Oxygen Species	90-113	signal transducer and activator of transcription 3	Mus musculus	185-190
24286865-4	2014	Surprisingly, increases in transcript levels of the direct STAT3 gene target SOCS3 were delayed during the combined LIF + H2O2 treatment, leading us to probe the impact of oxidative stress on STAT3 regulatory events.	Hydrogen Peroxide	122-126	signal transducer and activator of transcription 3	Mus musculus	59-64
24286865-5	2014	Indeed, LIF + H2O2 prolonged JAK activation, delayed STAT3 nuclear localisation, and caused relocalisation of nuclear STAT3 phosphatase TC-PTP (TC45) to the cytoplasm.	Hydrogen Peroxide	14-18	signal transducer and activator of transcription 3	Mus musculus	53-58
24286865-5	2014	Indeed, LIF + H2O2 prolonged JAK activation, delayed STAT3 nuclear localisation, and caused relocalisation of nuclear STAT3 phosphatase TC-PTP (TC45) to the cytoplasm.	Hydrogen Peroxide	14-18	signal transducer and activator of transcription 3	Mus musculus	118-123
24548419-2	2014	Here we studied the importance of STAT3 to the cellular response to stimuli, TNFalpha and serum deprivation, which increase mitochondrial reactive oxygen species (ROS) formation.	Reactive Oxygen Species	138-161	signal transducer and activator of transcription 3	Mus musculus	34-39
24548419-2	2014	Here we studied the importance of STAT3 to the cellular response to stimuli, TNFalpha and serum deprivation, which increase mitochondrial reactive oxygen species (ROS) formation.	Reactive Oxygen Species	163-166	signal transducer and activator of transcription 3	Mus musculus	34-39
24548419-7	2014	Deletion of STAT3 decreased ROS formation induced by TNFalpha and serum deprivation.	Reactive Oxygen Species	28-31	signal transducer and activator of transcription 3	Mus musculus	12-17
24500984-8	2014	Moreover, STAT3 inhibitor S3I-201 antagonized the induction of IL-10, arginase 1, and CD206 by MSC-CM in RAW264.7 cells.	NSC 74859	26-33	signal transducer and activator of transcription 3	Mus musculus	10-15
24489094-0	2014	Halofuginone-induced amino acid starvation regulates Stat3-dependent Th17 effector function and reduces established autoimmune inflammation.	halofuginone	0-12	signal transducer and activator of transcription 3	Mus musculus	53-58
24489094-4	2014	The prolyl-tRNA synthetase inhibitor halofuginone blocks IL-23-induced Stat3 phosphorylation and IL-23-dependent proinflammatory cytokine expression in endogenous CCR6(+) Th17 cells via activation of the amino acid starvation response (AAR) pathway.	halofuginone	37-49	signal transducer and activator of transcription 3	Mus musculus	71-76
24374810-8	2014	In ex vivo studies, treatment of the mice with DZ2002 suppressed the development of pathogenic Th17 cells, significantly decreased IL-17, TGF-beta, IL-6, and IL-23p19 production and impeded activation of the STAT3 protein and JNK/NF-kappaB signaling in splenocytes.	methyl 4-(adenin-9-yl)-2-hydroxybutanoate	47-53	signal transducer and activator of transcription 3	Mus musculus	208-213
24513872-8	2014	Interestingly, blocking antibody against IL-10 receptor and inhibition of STAT3 by STAT3 inhibitor S3I-201 attenuates stress-induced lymphocyte apoptosis.	NSC 74859	99-106	signal transducer and activator of transcription 3	Mus musculus	74-79
24513872-8	2014	Interestingly, blocking antibody against IL-10 receptor and inhibition of STAT3 by STAT3 inhibitor S3I-201 attenuates stress-induced lymphocyte apoptosis.	NSC 74859	99-106	signal transducer and activator of transcription 3	Mus musculus	83-88
24316209-0	2014	Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	91-96
24316209-0	2014	Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.	cucurbitacin I	19-33	signal transducer and activator of transcription 3	Mus musculus	91-96
24316209-1	2014	Cucurbitacin B, a member of the cucurbitaceae family, can act as a STAT3 signaling inhibitor to regulate the growth of hepatocellular carcinoma.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	67-72
24316209-3	2014	Based on these studies, we hypothesized that cucurbitacin B would prevent PPARgamma mediated adipocyte differentiation through STAT3 signaling.	cucurbitacin B	45-59	signal transducer and activator of transcription 3	Mus musculus	127-132
24316209-6	2014	Cucurbitacin B treatment impairs STAT3 signaling as manifested by reduced phosphorylation of STAT3 and suppression of STAT3 target gene expression in preadipocytes.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	33-38
24316209-6	2014	Cucurbitacin B treatment impairs STAT3 signaling as manifested by reduced phosphorylation of STAT3 and suppression of STAT3 target gene expression in preadipocytes.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	93-98
24316209-6	2014	Cucurbitacin B treatment impairs STAT3 signaling as manifested by reduced phosphorylation of STAT3 and suppression of STAT3 target gene expression in preadipocytes.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	93-98
24316209-7	2014	The anti-adipogenic effects of cucurbitacin B are significantly blunted in cells with STAT3 silenced by introducing small interfering RNA.	cucurbitacin B	31-45	signal transducer and activator of transcription 3	Mus musculus	86-91
24316209-8	2014	Finally, our data show that cucurbitacin I, another cucurbitacin family member, also inhibits adipocyte differentiation by suppressing STAT3 signaling.	cucurbitacin I	28-42	signal transducer and activator of transcription 3	Mus musculus	135-140
24316209-8	2014	Finally, our data show that cucurbitacin I, another cucurbitacin family member, also inhibits adipocyte differentiation by suppressing STAT3 signaling.	Cucurbitacins	28-40	signal transducer and activator of transcription 3	Mus musculus	135-140
23939942-8	2014	STAT3 degradation was induced by forced overexpression of the PPARalpha target gene-encoded enzyme ACOX1, which produces increased H(2)O(2) as a byproduct of fatty acid beta-oxidation.	Hydrogen Peroxide	131-139	signal transducer and activator of transcription 3	Mus musculus	0-5
23939942-8	2014	STAT3 degradation was induced by forced overexpression of the PPARalpha target gene-encoded enzyme ACOX1, which produces increased H(2)O(2) as a byproduct of fatty acid beta-oxidation.	Fatty Acids	158-168	signal transducer and activator of transcription 3	Mus musculus	0-5
24398427-6	2014	We find that systemic administration of AZD1480 readily replicates this effect, which is associated with reduced Stat3 activation and correlates with diminished tumor cell proliferation and increased apoptosis.	AZD 1480	40-47	signal transducer and activator of transcription 3	Mus musculus	113-118
24275163-0	2014	Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	55-60
24275163-5	2014	In this study, we sought to test the involvement of STAT3 signaling in the inhibitory effects of quercetin on melanoma cell growth, migration and invasion.	Quercetin	97-106	signal transducer and activator of transcription 3	Mus musculus	52-57
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	71-76
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	107-112
24275163-7	2014	Mechanistic study indicated that quercetin inhibited the activation of STAT3 signaling by interfering with STAT3 phosphorylation, and reducing STAT3 nuclear localization.	Quercetin	33-42	signal transducer and activator of transcription 3	Mus musculus	107-112
24275163-9	2014	Importantly, overexpression of constitutively active STAT3 partially rescued the growth inhibiting effects induced by quercetin.	Quercetin	118-127	signal transducer and activator of transcription 3	Mus musculus	53-58
24275163-10	2014	Furthermore, quercetin suppressed A375 tumor growth and STAT3 activities in xenografted mice model, and inhibited murine B16F10 cells lung metastasis in an animal model.	Quercetin	13-22	signal transducer and activator of transcription 3	Mus musculus	56-61
24275163-11	2014	Overall, these results indicate that the antitumor activity of quercetin is at least partially due to inhibition of STAT3 signaling in melanoma cells.	Quercetin	63-72	signal transducer and activator of transcription 3	Mus musculus	116-121
24275163-12	2014	Our findings provided new insight into the action of quercetin potently inhibits the STAT3 signaling pathway, suggesting it has a potential role in the prevention and treatment of melanoma.	Quercetin	53-62	signal transducer and activator of transcription 3	Mus musculus	85-90
24416452-7	2014	Moreover, niclosamide blocked breast cancer cells migration and invasion, and the reduction of phosphorylated STAT3(Tyr705), phosphorylated FAK(Tyr925) and phosphorylated Src(Tyr416) were also observed.	Niclosamide	10-21	signal transducer and activator of transcription 3	Mus musculus	110-115
24472312-9	2014	Ponatinib potently inhibited the phosphorylation of WT and T674I FIP1L1-PDGFRalpha and their downstream signaling molecules (e.g., Stat3, Stat5).	ponatinib	0-9	signal transducer and activator of transcription 3	Mus musculus	131-136
23318430-5	2014	A specific JAK2/STAT3 inhibitor FLLL32 delayed MPNST formation in an MPNST xenograft nude mouse model.	FLLL 32	32-38	signal transducer and activator of transcription 3	Mus musculus	16-21
23318430-9	2014	Efficacy of the FLLL32 pharmacological inhibitor in delaying MPNST growth suggests that combination therapies targeting JAK/STAT3 might be useful therapeutics.	FLLL 32	16-22	signal transducer and activator of transcription 3	Mus musculus	124-129
24404126-9	2014	Lastly, our data suggest that the antiangiogenic effects of STAT3 decoy oligonucleotide were mediatedthrough the inhibition of both STAT3 and STAT1.	Oligonucleotides	72-87	signal transducer and activator of transcription 3	Mus musculus	132-137
24404126-10	2014	CONCLUSIONS: The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies.	oligonucleotidewas	29-47	signal transducer and activator of transcription 3	Mus musculus	17-22
24404126-10	2014	CONCLUSIONS: The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies.	oligonucleotidewas	29-47	signal transducer and activator of transcription 3	Mus musculus	270-275
24404126-10	2014	CONCLUSIONS: The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies.	Oligonucleotides	29-44	signal transducer and activator of transcription 3	Mus musculus	17-22
24404126-10	2014	CONCLUSIONS: The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies.	Oligonucleotides	29-44	signal transducer and activator of transcription 3	Mus musculus	270-275
25169471-1	2014	BACKGROUND: The aim of this study was to investigate the effect of a Lipofectamine2000 (Life2000) Transfection Reagent transfected psiRNA-STAT3 plasmid on 4T1 breast cancer cells.	Lipofectamine	69-86	signal transducer and activator of transcription 3	Mus musculus	138-143
24125775-3	2014	For combined immunomodulation of DCs, poly (lactic-co-glycolic acid) (PLGA) NPs containing both small interfering RNA (siRNA) for the knock-down of immune-suppressor gene (signal transducer and activator of transcription-3, STAT3) of DCs and an immune response modifier (imiquimod, R837) for the activation of DCs through the toll-like receptor 7 (TLR7) were developed.	Polylactic Acid-Polyglycolic Acid Copolymer	38-68	signal transducer and activator of transcription 3	Mus musculus	172-222
24125775-3	2014	For combined immunomodulation of DCs, poly (lactic-co-glycolic acid) (PLGA) NPs containing both small interfering RNA (siRNA) for the knock-down of immune-suppressor gene (signal transducer and activator of transcription-3, STAT3) of DCs and an immune response modifier (imiquimod, R837) for the activation of DCs through the toll-like receptor 7 (TLR7) were developed.	Polylactic Acid-Polyglycolic Acid Copolymer	38-68	signal transducer and activator of transcription 3	Mus musculus	224-229
24095726-5	2013	Inhibition of HO-1 activity or HO-1 expression attenuated the effects of nicotine on STAT3 activation, TTP induction, and TNF-alpha production in LPS-treated macrophages.	Nicotine	73-81	signal transducer and activator of transcription 3	Mus musculus	85-90
24404126-0	2014	STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma.	Oligonucleotides	6-21	signal transducer and activator of transcription 3	Mus musculus	0-5
24404126-4	2014	EXPERIMENTAL DESIGN: A STAT3 decoy oligonucleotide and small interfering RNA (siRNA) were used to inhibit STAT3 in endothelial cells in vitro and in vivo.	Oligonucleotides	35-50	signal transducer and activator of transcription 3	Mus musculus	23-28
24404126-4	2014	EXPERIMENTAL DESIGN: A STAT3 decoy oligonucleotide and small interfering RNA (siRNA) were used to inhibit STAT3 in endothelial cells in vitro and in vivo.	Oligonucleotides	35-50	signal transducer and activator of transcription 3	Mus musculus	106-111
24404126-7	2014	RESULTS: STAT3 decoy oligonucleotide decreased proliferation, induces apoptosis, decreased migration, and decreased tubule formation of endothelial cells in vitro.	Oligonucleotides	21-36	signal transducer and activator of transcription 3	Mus musculus	9-14
24404126-8	2014	The STAT3 decoy oligonucleotide also inhibited tumor angiogenesis in murine tumor xenografts.	Oligonucleotides	16-31	signal transducer and activator of transcription 3	Mus musculus	4-9
24404126-9	2014	Lastly, our data suggest that the antiangiogenic effects of STAT3 decoy oligonucleotide were mediatedthrough the inhibition of both STAT3 and STAT1.	Oligonucleotides	72-87	signal transducer and activator of transcription 3	Mus musculus	60-65
24481266-9	2014	RESULTS: In cells treated with control-siRNA, GW3965 enhanced SOCS3 expression and significantly inhibited the phosphorylation of STAT3, NF-kappaB and AP1 expressions, accompanied by dramatically reduced cellular proliferation rate, immigration and invasion of cultured cells.	GW 3965	46-52	signal transducer and activator of transcription 3	Mus musculus	130-135
24200081-0	2014	Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway.	LC-1 compound	0-25	signal transducer and activator of transcription 3	Mus musculus	115-120
24200081-0	2014	Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway.	parthenolide	13-25	signal transducer and activator of transcription 3	Mus musculus	115-120
24200081-3	2014	These effects were paralleled by suppression of pSTAT3, Mcl-1 and cyclin D1 and PARP cleavage, suggesting that the antiproliferative and apoptotic effects of DMAPT could be mediated, at least in part, via suppression of the STAT3 signaling pathway.	LC-1 compound	158-163	signal transducer and activator of transcription 3	Mus musculus	49-54
24200081-7	2014	Given the evidence that STAT3 is activated in more than half of lung cancers and it regulates genes involved in cell proliferation, survival and angiogenesis, DMAPT is a promising agent for lung cancer chemoprevention in subjects who are at high risk of developing this devastating disease.	LC-1 compound	159-164	signal transducer and activator of transcription 3	Mus musculus	24-29
24239847-6	2014	EGCG also induced a higher Treg/Th17 cell ratio in CD4(+) T-cell differentiation by decreasing the ratio of STAT3/STAT5 expression in DIO mice.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	108-113
24239847-9	2014	Thus, EGCG has an anti-inflammatory effect by suppressing STAT3 proteins and Th17-cell differentiation.	epigallocatechin gallate	6-10	signal transducer and activator of transcription 3	Mus musculus	58-63
24239847-10	2014	EGCG thus shows promise for treating autoimmune conditions related to STAT3 or Th17 cells, such as metabolic syndrome, inflammatory arthritis, and some neoplastic diseases.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	70-75
25374443-9	2014	Furthermore, icariin inhibited STAT3 activation in T cells and STAT3 inhibitor resulted in decreased IL-17 production and alleviated RA.	icariin	13-20	signal transducer and activator of transcription 3	Mus musculus	31-36
22911886-0	2014	Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.	Serine	0-6	signal transducer and activator of transcription 3	Mus musculus	30-35
22911886-0	2014	Serine 727 phosphorylation of STAT3: an early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine.	Diethylnitrosamine	118-136	signal transducer and activator of transcription 3	Mus musculus	30-35
22911886-2	2014	We investigated STAT3 activation during hepatocarcinogenesis induced by neonatal diethylnitrosamine (DEN) treatment in mice.	Diethylnitrosamine	81-99	signal transducer and activator of transcription 3	Mus musculus	16-21
22911886-2	2014	We investigated STAT3 activation during hepatocarcinogenesis induced by neonatal diethylnitrosamine (DEN) treatment in mice.	Diethylnitrosamine	101-104	signal transducer and activator of transcription 3	Mus musculus	16-21
22911886-10	2014	Taken together, these data demonstrate that STAT3 activation, mainly through S727 phosphorylation, contributes to the DEN-induced hepatocarcinogenesis at the earliest stages.	Diethylnitrosamine	118-121	signal transducer and activator of transcription 3	Mus musculus	44-49
24240391-3	2014	Newly generated beta-like cells are epigenetically reprogrammed, functional and glucose responsive, and they reinstate normal glycemic control for up to 248 d. The regenerative process depends on Stat3 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells.	Glucose	80-87	signal transducer and activator of transcription 3	Mus musculus	196-201
24036260-9	2013	Findings in both in vitro and in vivo mechanistic studies are consistent with the supposition that the presently described liposomal formulation of curcumin inhibits tumor growth by blocking VEGF-induced STAT3 phosphorylation in tumor endothelium.	Curcumin	148-156	signal transducer and activator of transcription 3	Mus musculus	204-209
24132923-9	2013	Selumetinib treatment induced phosphorylation of STAT3 (Y705) only in resistant xenografts, and similar results were observed in BRAF(V600E) astrocytic cell lines intrinsically resistant to selumetinib.	AZD 6244	0-11	signal transducer and activator of transcription 3	Mus musculus	49-54
24132923-12	2013	In resistant tumors, selumetinib activated STAT3, and combined treatment with selumetinib and LLL12 induced complete responses in resistant BT-40 tumors.	AZD 6244	21-32	signal transducer and activator of transcription 3	Mus musculus	43-48
24132923-13	2013	These results suggest dual targeting BRAF (V600E) signaling and STAT3 signaling may be effective in selumetinib-resistant tumors or may retard or prevent onset of resistance.	AZD 6244	100-111	signal transducer and activator of transcription 3	Mus musculus	64-69
23820675-8	2013	Morphine treatment of transgenic mice resulted in phosphorylation of PDGFR-beta, MAPK/ERK, and signal transducer and activator of transcription 3 (Stat3) in the kidneys.	Morphine	0-8	signal transducer and activator of transcription 3	Mus musculus	95-145
23820675-8	2013	Morphine treatment of transgenic mice resulted in phosphorylation of PDGFR-beta, MAPK/ERK, and signal transducer and activator of transcription 3 (Stat3) in the kidneys.	Morphine	0-8	signal transducer and activator of transcription 3	Mus musculus	147-152
24095726-8	2013	Downregulation of STAT3 by siRNA attenuated the effect of nicotine on TTP expression and TNF-alpha production but did not affect the nicotine-mediated induction of HO-1.	Nicotine	58-66	signal transducer and activator of transcription 3	Mus musculus	18-23
24095726-9	2013	In TTP knockout mice, nicotine treatment enhanced HO-1 expression and STAT3 activation but failed to inhibit LPS-induced TNF-alpha production.	Nicotine	22-30	signal transducer and activator of transcription 3	Mus musculus	70-75
23726523-7	2013	The activation of STAT1 and STAT3 and the expression of Smad7 were also reduced after PG-MLA treatment in the colitic mice.	pg-mla	86-92	signal transducer and activator of transcription 3	Mus musculus	28-33
23726523-8	2013	These findings clearly suggest that PG-MLA treatment reduces intestinal Smad7 expression, restores TGF-beta1-3 signaling and reduces STAT1/STAT3 activation that may increase the number of Tregs to ameliorate chronic colitis.	pg-mla	36-42	signal transducer and activator of transcription 3	Mus musculus	139-144
24587049-7	2014	The results revealed that 2 h 150 microM or 200 microM resveratrol treatment leaded to remarkable S phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of STAT3, down-regulation of STAT3 downstream genes (survivin, cyclinD1, c-Myc and VEGF) and nuclear translocations of Sirt1 and p53.	Resveratrol	55-66	signal transducer and activator of transcription 3	Mus musculus	235-240
24587049-7	2014	The results revealed that 2 h 150 microM or 200 microM resveratrol treatment leaded to remarkable S phase arrest and apoptosis at 72 h time-point, accompanied with attenuated phosphorylation, nuclear translocation and transcription of STAT3, down-regulation of STAT3 downstream genes (survivin, cyclinD1, c-Myc and VEGF) and nuclear translocations of Sirt1 and p53.	Resveratrol	55-66	signal transducer and activator of transcription 3	Mus musculus	261-266
24587049-8	2014	The importance of STAT3 signaling in cell growth was confirmed by treating EJ cells with JAK2 inhibitor tyrphostin AG490.	Tyrphostins	104-114	signal transducer and activator of transcription 3	Mus musculus	18-23
24587049-9	2014	The efficacy and safety of resveratrol instillation were proved by the findings from nude mouse orthotopic xenograft models, because this treatment caused growth suppression, distinctive apoptosis and STAT3 inactivation of the transplanted tumors without affecting normal urothelium.	Resveratrol	27-38	signal transducer and activator of transcription 3	Mus musculus	201-206
25200830-4	2014	The aim of this study is to investigate the role of miR-17-5p in I/R-I and the underlying mechanism through targeting Stat3, a key surviving factor in cardiomyocytes.	mir-17-5p	52-61	signal transducer and activator of transcription 3	Mus musculus	118-123
25200830-12	2014	Furthermore, overexpression of miR-17-5p diminished the p-Stat3 level in response to H2O2.	mir-17-5p	31-40	signal transducer and activator of transcription 3	Mus musculus	58-63
25200830-12	2014	Furthermore, overexpression of miR-17-5p diminished the p-Stat3 level in response to H2O2.	Hydrogen Peroxide	85-89	signal transducer and activator of transcription 3	Mus musculus	58-63
25200830-14	2014	CONCLUSION: Upregulation of miR-17-5p promotes apoptosis induced by oxidative stress via targeting Stat3, accounting partially for I/R-I.	mir-17-5p	28-37	signal transducer and activator of transcription 3	Mus musculus	99-104
24095726-7	2013	In an LPS-induced endotoxemia model, HO-1 deficiency blocked the effects of nicotine on the STAT3 phosphorylation, TTP induction, and LPS-induced TNF-alpha production in the liver.	Nicotine	76-84	signal transducer and activator of transcription 3	Mus musculus	92-97
23922379-0	2013	Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages.	Adenosine	0-9	signal transducer and activator of transcription 3	Mus musculus	33-38
23949800-5	2013	In MCT cells, a mouse renal proximal tubule cell line, ATP depletion by antimycin A treatment upregulated survivin expression through a phospho-STAT3-dependent pathway.	Adenosine Triphosphate	55-58	signal transducer and activator of transcription 3	Mus musculus	144-149
23949800-5	2013	In MCT cells, a mouse renal proximal tubule cell line, ATP depletion by antimycin A treatment upregulated survivin expression through a phospho-STAT3-dependent pathway.	Antimycin A	72-83	signal transducer and activator of transcription 3	Mus musculus	144-149
23949800-8	2013	In MCT cells, inhibition of gamma-secretase similarly attenuated antimycin A-induced Notch-2 activation, upregulation of survivin, and phosphorylation of STAT3, but STAT3 kinase inhibition did not prevent Notch-2 activation.	Antimycin A	65-76	signal transducer and activator of transcription 3	Mus musculus	154-159
23922379-8	2013	In contrast to its stimulatory effect on IL-10-induced STAT3 activation, adenosine inhibited IL-6-induced STAT3 phosphorylation and SAA3 expression.	Adenosine	73-82	signal transducer and activator of transcription 3	Mus musculus	106-111
23922379-9	2013	In conclusion, adenosine enhances IL-10-induced STAT3 signaling and M2c macrophage activation.	Adenosine	15-24	signal transducer and activator of transcription 3	Mus musculus	48-53
24223168-0	2013	Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	58-63
24223168-2	2013	The role of Stat3 activation in iron-induced colonic inflammation and tumorigenesis was investigated in a mouse model of inflammation-associated colorectal cancer.	Iron	32-36	signal transducer and activator of transcription 3	Mus musculus	12-17
24223168-5	2013	Colonic inflammation was more severe in mice fed an iron-supplemented compared with a control diet one week post-DSS treatment, with enhanced colonic IL-6 and IL-11 release and Stat3 phosphorylation.	Iron	52-56	signal transducer and activator of transcription 3	Mus musculus	177-182
24223168-12	2013	Dietary iron and colonic inflammation synergistically activated colonic IL-6/IL-11-Stat3 signaling promoting tumorigenesis.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	83-88
24145455-1	2013	Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a genome-wide expression knockdown screen.	Retinoids	21-29	signal transducer and activator of transcription 3	Mus musculus	75-80
24223854-0	2013	Grape seed proanthocyanidin extract-mediated regulation of STAT3 proteins contributes to Treg differentiation and attenuates inflammation in a murine model of obesity-associated arthritis.	proanthocyanidin	11-27	signal transducer and activator of transcription 3	Mus musculus	59-64
23981351-9	2013	STAT1 and STAT3 also regulate glycerolipid and eicosanoid metabolism, respectively.	glycerolipid	30-42	signal transducer and activator of transcription 3	Mus musculus	10-15
23981351-9	2013	STAT1 and STAT3 also regulate glycerolipid and eicosanoid metabolism, respectively.	Eicosanoids	47-57	signal transducer and activator of transcription 3	Mus musculus	10-15
23897117-0	2013	Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway.	Fatty Acids, Unsaturated	0-27	signal transducer and activator of transcription 3	Mus musculus	108-113
23871934-6	2013	Under these conditions, self-renewal occurs without the need for LIF and is independent of nuclear translocation of tyrosine-phosphorylated STAT3 or beta-catenin, which have previously been implicated in self-renewal.	Tyrosine	116-124	signal transducer and activator of transcription 3	Mus musculus	140-145
23990113-7	2013	In addition, carfilzomib inhibited the growth and survival signaling pathways NF-kappaB and STAT3.	carfilzomib	13-24	signal transducer and activator of transcription 3	Mus musculus	92-97
24019511-0	2013	Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727.	Serine	83-89	signal transducer and activator of transcription 3	Mus musculus	24-29
24019511-6	2013	Substitution of Ser-727 for an alanine or aspartate in Stat3 that has a mitochondrial localization sequence, MLS-Stat3, has profound effects on tumor growth, complex I activity of the ETC, and accumulation of reactive oxygen species (ROS).	Reactive Oxygen Species	209-232	signal transducer and activator of transcription 3	Mus musculus	55-60
24019511-6	2013	Substitution of Ser-727 for an alanine or aspartate in Stat3 that has a mitochondrial localization sequence, MLS-Stat3, has profound effects on tumor growth, complex I activity of the ETC, and accumulation of reactive oxygen species (ROS).	Reactive Oxygen Species	234-237	signal transducer and activator of transcription 3	Mus musculus	55-60
24019511-7	2013	Cells expressing MLS-Stat3(S727A) display slower tumor growth, decreased complex I activity of the ETC, and increased ROS accumulation under hypoxia compared with cells expressing MLS-Stat3.	Reactive Oxygen Species	118-121	signal transducer and activator of transcription 3	Mus musculus	21-26
24019511-8	2013	In contrast, cells expressing MLS-Stat3(S727D) show enhanced tumor growth and complex I activity and decreased production of ROS.	Reactive Oxygen Species	125-128	signal transducer and activator of transcription 3	Mus musculus	34-39
24152426-7	2013	STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05).	Streptozocin	68-71	signal transducer and activator of transcription 3	Mus musculus	0-5
24152426-7	2013	STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05).	Streptozocin	125-128	signal transducer and activator of transcription 3	Mus musculus	0-5
24260381-9	2013	Furthermore, scoparone treatment suppressed anchorage-independent growth in soft agar and tumor growth of DU145 xenografts in nude mice, concomitant with a reduction in STAT3 phosphorylation.	scoparone	13-22	signal transducer and activator of transcription 3	Mus musculus	169-174
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	signal transducer and activator of transcription 3	Mus musculus	67-72
24204898-6	2013	We further show that LepRb activates STAT3 phosphorylation in neuronal fibers within several hypothalamic and hindbrain nuclei of wild-type mice and rats, and specifically in dendrites of arcuate POMC and AgRP/NPY/GABA neurons of Leprb (+/+) mice and in Leprb (db/db) mice expressing HA-LepRb in a neuron specific manner.	gamma-Aminobutyric Acid	214-218	signal transducer and activator of transcription 3	Mus musculus	37-42
24204898-9	2013	In addition, we found that the leptin activates STAT3 signaling in proximity to synapses on POMC and AgRP/NPY/GABA dendritic shafts.	gamma-Aminobutyric Acid	110-114	signal transducer and activator of transcription 3	Mus musculus	48-53
23742171-9	2013	Iron and EtOH feeding markedly reduced p-STAT3 and p-AMPK protein levels, but this effect was significantly attenuated when a CO diet was consumed.	Iron	0-4	signal transducer and activator of transcription 3	Mus musculus	41-46
23742171-9	2013	Iron and EtOH feeding markedly reduced p-STAT3 and p-AMPK protein levels, but this effect was significantly attenuated when a CO diet was consumed.	Ethanol	9-13	signal transducer and activator of transcription 3	Mus musculus	41-46
23894061-7	2013	RESULTS: Augmented gp130/STAT3 signalling enhanced TH-17 commitment in vitro and exacerbated joint pathology.	Thorium	51-53	signal transducer and activator of transcription 3	Mus musculus	25-30
23848338-7	2013	Vanadate treatment reversed emodin-induced down-regulation of STAT3, suggesting the involvement of a tyrosine phosphatase and emodin induced the expression of the tyrosine phosphatase SHP-1 that correlated with the down-regulation of constitutive STAT3 activation.	Vanadates	0-8	signal transducer and activator of transcription 3	Mus musculus	62-67
23848338-7	2013	Vanadate treatment reversed emodin-induced down-regulation of STAT3, suggesting the involvement of a tyrosine phosphatase and emodin induced the expression of the tyrosine phosphatase SHP-1 that correlated with the down-regulation of constitutive STAT3 activation.	Vanadates	0-8	signal transducer and activator of transcription 3	Mus musculus	247-252
23722419-7	2013	Pitavastatin treatment inhibited the phosphorylation of signal transducer and activator of transcription (STAT)3 and STAT4, which have key roles in the Th1 and Th17 lineage commitment, respectively, in the heart, and suppressed production of Th1 cytokine interferon-gamma and Th17 cytokine interleukin-17 from autoreactive CD4(+) T cells.	pitavastatin	0-12	signal transducer and activator of transcription 3	Mus musculus	56-112
23816536-0	2013	Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.	betulinic acid	0-14	signal transducer and activator of transcription 3	Mus musculus	85-90
23816536-0	2013	Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.	betulin	19-26	signal transducer and activator of transcription 3	Mus musculus	85-90
23816536-0	2013	Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.	Ethanol	44-51	signal transducer and activator of transcription 3	Mus musculus	85-90
23816536-7	2013	BA or BT administration significantly decreased the expression of TLR4, and increased the phosphorylation of STAT3.	betulinic acid	0-2	signal transducer and activator of transcription 3	Mus musculus	109-114
23816536-7	2013	BA or BT administration significantly decreased the expression of TLR4, and increased the phosphorylation of STAT3.	betulin	6-8	signal transducer and activator of transcription 3	Mus musculus	109-114
23816536-8	2013	In vitro, BA or BT treatment reduced the expressions of alpha-SMA and collagen-I in ethanol-stimulated HSCs via regulation of TLR4 and STAT3, coincided with in vivo.	betulinic acid	10-12	signal transducer and activator of transcription 3	Mus musculus	135-140
23816536-8	2013	In vitro, BA or BT treatment reduced the expressions of alpha-SMA and collagen-I in ethanol-stimulated HSCs via regulation of TLR4 and STAT3, coincided with in vivo.	betulin	16-18	signal transducer and activator of transcription 3	Mus musculus	135-140
23816536-9	2013	All of these findings demonstrated that BA or BT might ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro, promising agents for ethanol-induced fatty liver therapies.	betulinic acid	40-42	signal transducer and activator of transcription 3	Mus musculus	113-118
23816536-9	2013	All of these findings demonstrated that BA or BT might ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro, promising agents for ethanol-induced fatty liver therapies.	betulin	46-48	signal transducer and activator of transcription 3	Mus musculus	113-118
23856612-0	2013	Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	85-90
23856612-0	2013	Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway.	Dextran Sulfate	21-43	signal transducer and activator of transcription 3	Mus musculus	85-90
23856612-2	2013	The purpose of the study was to investigate whether curcumin could exert its therapeutic effects in experimental colitis by inhibiting STAT3 pathway.	Curcumin	52-60	signal transducer and activator of transcription 3	Mus musculus	135-140
23856612-10	2013	CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	93-98
23856612-10	2013	CONCLUSION: Curcumin exerts beneficial effects in experimental colitis by the suppression of STAT3 pathway, which may therefore provide a better understanding of the mechanism of action for curcumin in treating colitis.	Curcumin	190-198	signal transducer and activator of transcription 3	Mus musculus	93-98
23948302-0	2013	STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.	Sorafenib	96-105	signal transducer and activator of transcription 3	Mus musculus	0-5
23897117-8	2013	Inhibition of STAT3 phosphorylation by JAK inhibitor JSI-124 almost completely abrogated the effects of PUFAs on MDSCs.	cucurbitacin I	53-60	signal transducer and activator of transcription 3	Mus musculus	14-19
23905628-6	2013	Meanwhile, CD4(+) /CD25(+) regulatory T cells more significantly increase in NZB/W F1 mice receiving cystamine than in those mice receiving PBS, accompanied by significantly reduced IL-6/phosphorylated STAT-3 expression.	Cystamine	101-110	signal transducer and activator of transcription 3	Mus musculus	202-208
23905628-7	2013	The above findings suggest the beneficial effects of cystamine in terms of increasing antioxidant activities and CD4(+) /CD25(+) regulatory T cells in lupus-prone mice by suppressing IL-6/STAT3 signalling.	Cystamine	53-62	signal transducer and activator of transcription 3	Mus musculus	188-193
24204197-11	2013	In addition, PFTS proved to be a strong combination partner with phospho-valproic acid, a novel signal transducer and activator of transcription 3 (STAT3) inhibitor, displaying synergy in the inhibition of pancreatic cancer growth.	phospho-valproic acid	65-86	signal transducer and activator of transcription 3	Mus musculus	96-146
23948302-4	2013	Furthermore, sorafenib treatment resulted in translocation of cytoplasmic STAT3 to the nucleus in its active form.	Sorafenib	13-22	signal transducer and activator of transcription 3	Mus musculus	74-79
23948302-5	2013	Based on this observation, we used hepatocyte-specific STAT3 knockout (STAT3(Hep-/-)) mice to demonstrate that hepatic STAT3 was critical for sorafenib-mediated protection against liver fibrosis, and that the upregulation of STAT3 phosphorylation was dependent on Kupffer cell-derived IL-6.	Sorafenib	142-151	signal transducer and activator of transcription 3	Mus musculus	55-60
23948302-5	2013	Based on this observation, we used hepatocyte-specific STAT3 knockout (STAT3(Hep-/-)) mice to demonstrate that hepatic STAT3 was critical for sorafenib-mediated protection against liver fibrosis, and that the upregulation of STAT3 phosphorylation was dependent on Kupffer cell-derived IL-6.	Sorafenib	142-151	signal transducer and activator of transcription 3	Mus musculus	71-76
23948302-5	2013	Based on this observation, we used hepatocyte-specific STAT3 knockout (STAT3(Hep-/-)) mice to demonstrate that hepatic STAT3 was critical for sorafenib-mediated protection against liver fibrosis, and that the upregulation of STAT3 phosphorylation was dependent on Kupffer cell-derived IL-6.	Sorafenib	142-151	signal transducer and activator of transcription 3	Mus musculus	71-76
23948302-5	2013	Based on this observation, we used hepatocyte-specific STAT3 knockout (STAT3(Hep-/-)) mice to demonstrate that hepatic STAT3 was critical for sorafenib-mediated protection against liver fibrosis, and that the upregulation of STAT3 phosphorylation was dependent on Kupffer cell-derived IL-6.	Sorafenib	142-151	signal transducer and activator of transcription 3	Mus musculus	71-76
23869429-7	2013	Our results also show that visfatin-induced iNOS expression and NO production were significantly inhibited by melatonin, an effect that was closely associated with a reduction in phosphorylated JAK2/STAT3 levels and with the inhibition of p65 translocation into nucleus.	Melatonin	110-119	signal transducer and activator of transcription 3	Mus musculus	199-204
23869429-8	2013	In conclusion, our data show, for the first time, that melatonin suppresses visfatin-induced iNOS upregulation in macrophages by inhibiting the STAT3 and NF-kappaB pathways.	Melatonin	55-64	signal transducer and activator of transcription 3	Mus musculus	144-149
23871159-0	2013	Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells.	Dexamethasone	64-77	signal transducer and activator of transcription 3	Mus musculus	23-28
23871159-0	2013	Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells.	Dexamethasone	95-108	signal transducer and activator of transcription 3	Mus musculus	23-28
23871159-4	2013	Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon.	Dexamethasone	66-69	signal transducer and activator of transcription 3	Mus musculus	110-115
23871159-4	2013	Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon.	Dexamethasone	66-69	signal transducer and activator of transcription 3	Mus musculus	110-115
24204197-11	2013	In addition, PFTS proved to be a strong combination partner with phospho-valproic acid, a novel signal transducer and activator of transcription 3 (STAT3) inhibitor, displaying synergy in the inhibition of pancreatic cancer growth.	phospho-valproic acid	65-86	signal transducer and activator of transcription 3	Mus musculus	148-153
23970425-10	2013	Moreover, the activation of NF-kappaB p65 as well as STAT3 in dextran sulfate sodium-treated colon tissues was significantly reduced by apocynin.	Dextran Sulfate	62-84	signal transducer and activator of transcription 3	Mus musculus	53-58
24052073-7	2013	Conditional STAT3 knockdown in RGCs did not affect the survival of RGCs after optic nerve injury compared with controls, but significantly reduced the neuroprotective effects of IS.	is	178-180	signal transducer and activator of transcription 3	Mus musculus	12-17
23811270-0	2013	Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-kappaB and STAT3 as potential targets.	diallyl trisulfide	0-18	signal transducer and activator of transcription 3	Mus musculus	90-95
23793040-8	2013	The protective effect of alpha-lipoic acid was mediated through the modulation of nuclear factor kappa B, cyclooxygenase-2, interleukin 17, signal transducer and activator of transcription 3, nuclear erythroid 2-related factor 2, NADPH: quinone oxidoreductase-1, matrix metalloproteinase-9 and connective tissue growth factor.	Thioctic Acid	25-42	signal transducer and activator of transcription 3	Mus musculus	140-228
23803415-4	2013	We found that garcinol inhibited constitutively activated STAT3 in HNSCC cells in a time- and dose-dependent manner, which correlated with the suppression of the upstream kinases (c-Src, JAK1, and JAK2) in HNSCC cells.	garcinol	14-22	signal transducer and activator of transcription 3	Mus musculus	58-63
23803415-5	2013	Also, we noticed that the generation of reactive oxygen species is involved in STAT3 inhibitory effect of garcinol.	Reactive Oxygen Species	40-63	signal transducer and activator of transcription 3	Mus musculus	79-84
23803415-5	2013	Also, we noticed that the generation of reactive oxygen species is involved in STAT3 inhibitory effect of garcinol.	garcinol	106-114	signal transducer and activator of transcription 3	Mus musculus	79-84
23823704-12	2013	The IL-6/STAT3 signaling pathway was attenuated in oroxylin A-treated mice.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	51-61	signal transducer and activator of transcription 3	Mus musculus	9-14
23823704-13	2013	CONCLUSIONS: Our results demonstrated that oroxylin A inhibits colitis-associated carcinogenesis through modulating IL-6/STAT3 pathway in AOM/dextran sodium sulfate mouse model and in HCT-116 cells.	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	43-53	signal transducer and activator of transcription 3	Mus musculus	121-126
23923060-12	2013	Therefore, our current study supports that the glucose intolerance and in vivo insulin secretion defect in pancreas-specific STAT3-KO mice is due to altered microvasculature in the pancreas, and not intrinsic beta-cell function.	Glucose	47-54	signal transducer and activator of transcription 3	Mus musculus	125-130
23811326-8	2013	All tumor-bearing mice had increased serum bile acid levels and IL-6 levels, which was associated with activation of hepatic STAT3.	Bile Acids and Salts	43-52	signal transducer and activator of transcription 3	Mus musculus	125-130
22748497-9	2013	CONCLUSIONS: Resveratrol enhanced NF-kappaB activity in human and murine cardiac cells, in a process that coincided with the activation of STAT3 and anti-apoptotic downstream effectors.	Resveratrol	13-24	signal transducer and activator of transcription 3	Mus musculus	139-144
23027128-2	2013	Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing signal transducer and activator of transcription 3 activation.	Azoxymethane	29-41	signal transducer and activator of transcription 3	Mus musculus	92-142
23811270-6	2013	In conclusion, DATS ameliorates the DSS-induced mouse colitis presumably by blocking inflammatory signaling mediated by NF-kappaB and STAT3.	diallyl trisulfide	15-19	signal transducer and activator of transcription 3	Mus musculus	134-139
23811270-6	2013	In conclusion, DATS ameliorates the DSS-induced mouse colitis presumably by blocking inflammatory signaling mediated by NF-kappaB and STAT3.	Dextran Sulfate	36-39	signal transducer and activator of transcription 3	Mus musculus	134-139
23665018-9	2013	Interestingly, AG490 partly inhibited RANKL-induced phosphorylation of Ser(727) in STAT3.	Serine	71-74	signal transducer and activator of transcription 3	Mus musculus	83-88
23685554-4	2013	Here, we tested the relationship of IL-6-signal transducer and activator of transcription-3 signaling with Th17-induced inflammation in the formation of Ang II-induced dissections in C57BL/6 mice.	th17	107-111	signal transducer and activator of transcription 3	Mus musculus	41-91
23394584-3	2013	Under the same experimental conditions, oligonol administration significantly inhibited the activation of nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 3 and expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and cyclin D1 in the mouse colon.	oligonol	40-48	signal transducer and activator of transcription 3	Mus musculus	133-190
23673666-0	2013	Identification of canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the intracellular domain of the interleukin 23 receptor.	Tyrosine	65-73	signal transducer and activator of transcription 3	Mus musculus	86-91
23673666-6	2013	Second, we identified a non-canonical, phosphotyrosine-independent STAT3 activation motif within the IL-23R.	Phosphotyrosine	39-54	signal transducer and activator of transcription 3	Mus musculus	67-72
23673666-9	2013	In summary, we characterized IL-23-dependent signal transduction with a focus on STAT3 phosphorylation and identified canonical tyrosine-dependent and non-canonical tyrosine-independent STAT3 activation sites in the IL-23R.	Tyrosine	165-173	signal transducer and activator of transcription 3	Mus musculus	186-191
23636127-0	2013	miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma.	mir-124	0-7	signal transducer and activator of transcription 3	Mus musculus	17-22
23636127-2	2013	On the basis of miRNA gene expression in gliomas using tissue microarrays, in situ hybridization, and molecular modeling, miR-124 was identified as a lead candidate for modulating STAT3 signaling, a key pathway mediating immunosuppression in the tumor microenvironment.	mir-124	122-129	signal transducer and activator of transcription 3	Mus musculus	180-185
23636127-4	2013	Upon upregulating miR-124 in glioma cancer stem cells (gCSC), the STAT3 pathway was inhibited, and miR-124 reversed gCSC-mediated immunosuppression of T-cell proliferation and induction of forkhead box P3 (Foxp3)(+) regulatory T cells (Treg).	mir-124	18-25	signal transducer and activator of transcription 3	Mus musculus	66-71
23636127-4	2013	Upon upregulating miR-124 in glioma cancer stem cells (gCSC), the STAT3 pathway was inhibited, and miR-124 reversed gCSC-mediated immunosuppression of T-cell proliferation and induction of forkhead box P3 (Foxp3)(+) regulatory T cells (Treg).	gcsc	55-59	signal transducer and activator of transcription 3	Mus musculus	66-71
23474485-3	2013	Here, we show that increased plasma histidine results in hepatic STAT3 activation.	Histidine	36-45	signal transducer and activator of transcription 3	Mus musculus	65-70
23474485-4	2013	Intravenous and intracerebroventricular (ICV) administration of histidine-activated hepatic STAT3 reduced G6Pase protein and mRNA levels and augmented HGP suppression by insulin.	Histidine	64-73	signal transducer and activator of transcription 3	Mus musculus	92-97
23474485-7	2013	Therefore, histidine activates hepatic STAT3 and suppresses HGP via central histamine action.	Histidine	11-20	signal transducer and activator of transcription 3	Mus musculus	39-44
23474485-8	2013	Hepatic STAT3 phosphorylation after histidine ICV administration was attenuated in histamine H1 receptor knockout (Hrh1KO) mice but not in neuron-specific insulin receptor knockout (NIRKO) mice.	histidine icv	36-49	signal transducer and activator of transcription 3	Mus musculus	8-13
23530005-3	2013	In contrast, activation of signal transducer and activator of transcription 3 (STAT3), but not the MEK-ERK pathway, in the VMH by leptin enhances the insulin-induced suppression of endogenous glucose production in an MCR-independent manner, with this effect of leptin occurring only in the presence of an increased plasma concentration of insulin.	Glucose	192-199	signal transducer and activator of transcription 3	Mus musculus	27-77
23530005-3	2013	In contrast, activation of signal transducer and activator of transcription 3 (STAT3), but not the MEK-ERK pathway, in the VMH by leptin enhances the insulin-induced suppression of endogenous glucose production in an MCR-independent manner, with this effect of leptin occurring only in the presence of an increased plasma concentration of insulin.	Glucose	192-199	signal transducer and activator of transcription 3	Mus musculus	79-84
23613111-0	2013	Nitidine chloride inhibits hepatocellular carcinoma cell growth in vivo through the suppression of the JAK1/STAT3 signaling pathway.	nitidine	0-17	signal transducer and activator of transcription 3	Mus musculus	108-113
23389690-8	2013	Furthermore, AG significantly inhibited the attenuating effects of McN on decreased NMDAR-dependent LTP, protein kinase C betaII, p-ERK, p-CREB, BDNF, and p-JAK2/p-STAT3-expression in klotho mutant mice.	mcn	67-70	signal transducer and activator of transcription 3	Mus musculus	164-169
23389690-9	2013	In addition, k252a, a BDNF receptor tyrosine kinase B (TrkB) inhibitor, significantly counteracted McN effects on decreased ChAT, ACh, and M1 mAChR and p-JAK2/p-STAT3 expression.	mcn	99-102	signal transducer and activator of transcription 3	Mus musculus	161-166
23807298-4	2013	Stat3 was observed at 7 through 9 dop in both the antimesometrial and mesometrial deciduas, while continued immunoreactivity between 10 and 13 dop was seen only in the mesometrial decidua.	9 dop	32-37	signal transducer and activator of transcription 3	Mus musculus	0-5
23825527-6	2013	These data indicated that inhibition of STAT3 activity of TAMs by HC-NPs was able to reverse their phenotype and could regulate their crosstalk between tumor cells and TAMs in order to suppress tumor progression.	tams	58-62	signal transducer and activator of transcription 3	Mus musculus	40-45
23499905-0	2013	IL-6 attenuates trimethyltin-induced cognitive dysfunction via activation of JAK2/STAT3, M1 mAChR and ERK signaling network.	trimethyltin	16-28	signal transducer and activator of transcription 3	Mus musculus	82-87
23643741-11	2013	Triptolide significantly induced SOCS3 protein and reduced STAT3 target anti-apoptotic genes Bcl-2 and Bcl-xl in LPMCs.	triptolide	0-10	signal transducer and activator of transcription 3	Mus musculus	59-64
23643741-11	2013	Triptolide significantly induced SOCS3 protein and reduced STAT3 target anti-apoptotic genes Bcl-2 and Bcl-xl in LPMCs.	lpmcs	113-118	signal transducer and activator of transcription 3	Mus musculus	59-64
23643741-13	2013	CONCLUSIONS: Our results indicated that triptolide therapy may restore the homeostatic balance of LP-T cell apoptosis within the gut, and demonstrate a novel mechanism of action of triptolide therapy mediated through regulation IL-6/STAT3/SOCS3 signaling pathway.	triptolide	40-50	signal transducer and activator of transcription 3	Mus musculus	233-238
23643741-13	2013	CONCLUSIONS: Our results indicated that triptolide therapy may restore the homeostatic balance of LP-T cell apoptosis within the gut, and demonstrate a novel mechanism of action of triptolide therapy mediated through regulation IL-6/STAT3/SOCS3 signaling pathway.	triptolide	181-191	signal transducer and activator of transcription 3	Mus musculus	233-238
23462572-6	2013	When we administered NSC74859, a specific inhibitor of phosphorylated STAT3 (pSTAT3), the water content became normalized.	Water	90-95	signal transducer and activator of transcription 3	Mus musculus	70-75
25337545-0	2013	Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	18-23
25337545-0	2013	Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice.	Dextran Sulfate	50-72	signal transducer and activator of transcription 3	Mus musculus	18-23
25337545-5	2013	Our study revealed that administration of curcumin significantly attenuated the severity of DSS-induced colitis and STAT3 signaling in mouse colon.	Curcumin	42-50	signal transducer and activator of transcription 3	Mus musculus	116-121
23692080-0	2013	Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.	ethyl modified	75-89	signal transducer and activator of transcription 3	Mus musculus	119-169
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	danvatirsen	0-11	signal transducer and activator of transcription 3	Mus musculus	109-159
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	danvatirsen	0-11	signal transducer and activator of transcription 3	Mus musculus	161-166
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	Parathion	50-66	signal transducer and activator of transcription 3	Mus musculus	161-166
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	Oligonucleotides	77-92	signal transducer and activator of transcription 3	Mus musculus	109-159
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	Oligonucleotides	77-92	signal transducer and activator of transcription 3	Mus musculus	161-166
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	Oligonucleotides, Antisense	94-97	signal transducer and activator of transcription 3	Mus musculus	109-159
23692080-1	2013	ISIS 481464 is a constrained ethyl (cEt) modified phosphorothioate antisense oligonucleotide (ASO) targeting signal transducer and activator of transcription 3 (STAT3) studied in mice and monkey to support oncology clinical trials.	Oligonucleotides, Antisense	94-97	signal transducer and activator of transcription 3	Mus musculus	161-166
23693126-8	2013	This selective inhibitory pathway phosphorylated STAT3 on its inhibitory ser-727 residue interfering with activity of the pro-transcription Tyr-705 residue.	Serine	73-76	signal transducer and activator of transcription 3	Mus musculus	49-54
23693126-8	2013	This selective inhibitory pathway phosphorylated STAT3 on its inhibitory ser-727 residue interfering with activity of the pro-transcription Tyr-705 residue.	Tyrosine	140-143	signal transducer and activator of transcription 3	Mus musculus	49-54
23630282-6	2013	To assess CBLB502 impact on other pathways, we created multireporter mice with hepatocytes transduced in vivo with reporters for 46 inducible transcription factor families and found that along with NF-kappaB, CBLB502 strongly activated STAT3-, phenobarbital-responsive enhancer module (PREM), and activator protein 1 (AP-1-) -driven pathways.	CBLB502	209-216	signal transducer and activator of transcription 3	Mus musculus	236-241
23595215-8	2013	Furthermore, ischemic preconditioning (IPC, 4 cycles of 3.5 min of ischemia and 5 min of reperfusion) increased phosphorylation of ERK-1/2, GSK3beta, and STAT3 in all hearts without differences between groups (n = 5-6, p < 0.05), although Cx43 deficient mice were not protected by either IPC or pharmacological preconditioning with diazoxide.	ipc	39-42	signal transducer and activator of transcription 3	Mus musculus	154-159
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	3-11	signal transducer and activator of transcription 3	Mus musculus	74-79
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Simvastatin	96-107	signal transducer and activator of transcription 3	Mus musculus	136-141
22835616-6	2013	In poly I:C-stimulated bronchial cells, RANTES secretion was increased by STAT3 activation, and simvastatin suppressed poly I:C-induced STAT3 activation, resulting in inhibition of RANTES expression.	Poly I-C	119-127	signal transducer and activator of transcription 3	Mus musculus	136-141
22835616-8	2013	However, simvastatin treatment attenuated STAT3 activation, RANTES release and subsequent neutrophilia in the lungs.	Simvastatin	9-20	signal transducer and activator of transcription 3	Mus musculus	42-47
23529161-2	2013	The current study tested the hypothesis that Stat3 signaling in proopiomelanocortin (POMC) neurons mediates the chronic effects of leptin on mean arterial pressure (MAP), as well as on glucose regulation, energy expenditure, and food intake.	Glucose	185-192	signal transducer and activator of transcription 3	Mus musculus	45-50
23529161-6	2013	Stat3(flox/flox)/POMC-Cre mice were hyperphagic, heavier, and had increased respiratory quotients compared with control Stat3(flox/flox) mice.	flox	6-10	signal transducer and activator of transcription 3	Mus musculus	0-5
23529161-6	2013	Stat3(flox/flox)/POMC-Cre mice were hyperphagic, heavier, and had increased respiratory quotients compared with control Stat3(flox/flox) mice.	flox	11-15	signal transducer and activator of transcription 3	Mus musculus	0-5
23529161-6	2013	Stat3(flox/flox)/POMC-Cre mice were hyperphagic, heavier, and had increased respiratory quotients compared with control Stat3(flox/flox) mice.	flox	11-15	signal transducer and activator of transcription 3	Mus musculus	0-5
23529161-6	2013	Stat3(flox/flox)/POMC-Cre mice were hyperphagic, heavier, and had increased respiratory quotients compared with control Stat3(flox/flox) mice.	flox	11-15	signal transducer and activator of transcription 3	Mus musculus	0-5
23529161-9	2013	However, leptin-mediated increases in MAP were completely abolished, and blood pressure responses to acute air-jet stress were attenuated in male Stat3(flox/flox)/POMC-Cre mice.	flox	152-156	signal transducer and activator of transcription 3	Mus musculus	146-151
23529161-9	2013	However, leptin-mediated increases in MAP were completely abolished, and blood pressure responses to acute air-jet stress were attenuated in male Stat3(flox/flox)/POMC-Cre mice.	flox	157-161	signal transducer and activator of transcription 3	Mus musculus	146-151
23455376-7	2013	An inhibitor of the STAT3 signaling pathway, AG490 suppressed the tumor formation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	45-50	signal transducer and activator of transcription 3	Mus musculus	20-25
23528535-7	2013	Propranolol ophthalmic solutions reduced VEGF and IGF-1 up-regulation in response to hypoxia and drastically inhibited HIF-1alpha accumulation and STAT3 phosphorylation.	Propranolol	0-11	signal transducer and activator of transcription 3	Mus musculus	147-152
23364341-0	2013	Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation.	Serine	107-113	signal transducer and activator of transcription 3	Mus musculus	101-106
23460517-4	2013	Hepatocyte-specific mutation of STAT3 prevented the induction of these secretory pathways during pneumonia, with similar results observed following pharmacological activation of ER stress by using tunicamycin.	Tunicamycin	197-208	signal transducer and activator of transcription 3	Mus musculus	32-37
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	andrographolide	10-25	signal transducer and activator of transcription 3	Mus musculus	53-103
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	andrographolide	10-25	signal transducer and activator of transcription 3	Mus musculus	105-110
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	zinc protoporphyrin	130-134	signal transducer and activator of transcription 3	Mus musculus	53-103
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	zinc protoporphyrin	130-134	signal transducer and activator of transcription 3	Mus musculus	105-110
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	Cesium	148-150	signal transducer and activator of transcription 3	Mus musculus	53-103
23629921-5	2013	Moreover, andrographolide-induced phosphorylation of signal transducer and activator of transcription 3 (STAT3) was attenuated by ZnPP treatment in CS-exposed animals.	Cesium	148-150	signal transducer and activator of transcription 3	Mus musculus	105-110
23629921-6	2013	Our data collectively demonstrate that andrographolide confers protection against CS-induced lung inflammation, partially through activation of HO-1 and STAT3.	andrographolide	39-54	signal transducer and activator of transcription 3	Mus musculus	153-158
23629921-6	2013	Our data collectively demonstrate that andrographolide confers protection against CS-induced lung inflammation, partially through activation of HO-1 and STAT3.	Cesium	82-84	signal transducer and activator of transcription 3	Mus musculus	153-158
23333931-0	2013	25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice.	Calcifediol	0-20	signal transducer and activator of transcription 3	Mus musculus	99-104
23428347-0	2013	Bortezomib enhances antigen-specific cytotoxic T cell responses against immune-resistant cancer cells generated by STAT3-ablated dendritic cells.	Bortezomib	0-10	signal transducer and activator of transcription 3	Mus musculus	115-120
23428347-9	2013	These results suggest that the anti-tumor effects against a p53-degraded immune resistant variant generated by antigen-expressing STAT3-ablated mature DCs may be enhanced by bortezomib via death receptor-mediated apoptosis.	Bortezomib	174-184	signal transducer and activator of transcription 3	Mus musculus	130-135
23650499-0	2013	Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.	phospho-valproic acid	45-66	signal transducer and activator of transcription 3	Mus musculus	24-29
23650499-0	2013	Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice.	MDC-1112	68-76	signal transducer and activator of transcription 3	Mus musculus	24-29
23613996-2	2013	One of Stat3 downstream genes products, chitinase 3-like 1 (CHI3L1) protein, showed increased concentration in both bronchioalveolar lavage fluid (BALF) and blood of doxycycline-treated CCSP-rtTA/(tetO)7-CMV-Stat3C bitransgenic mice.	Doxycycline	166-177	signal transducer and activator of transcription 3	Mus musculus	7-12
23593315-6	2013	Moreover, minocycline down-regulated two major components of IL-6 receptor system (IL-6Ralpha and gp130) and blocked the activation of STAT3 and ERK1/2 pathways leading to suppression of the downstream product MCL-1.	Minocycline	10-21	signal transducer and activator of transcription 3	Mus musculus	135-140
23593315-9	2013	In line with this, tumoral expression of p-STAT3, p-ERK1/2 and MCL-1 were decreased in minocycline-treated mice.	Minocycline	87-98	signal transducer and activator of transcription 3	Mus musculus	43-48
23406906-0	2013	Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes.	Tacrolimus	44-54	signal transducer and activator of transcription 3	Mus musculus	110-115
23688998-0	2013	[Effect of dexamethasone on expression of interleukin-21 and phospho-STAT3 in a murine model of chronic asthma].	Dexamethasone	11-24	signal transducer and activator of transcription 3	Mus musculus	69-74
23688998-1	2013	OBJECTIVE: To investigate the effects of dexamethasone on the expression of interleukin-21 (IL-21) and phospho- STAT3 (p-STAT3) in a murine model of chronic asthma.	Dexamethasone	41-54	signal transducer and activator of transcription 3	Mus musculus	112-117
23688998-1	2013	OBJECTIVE: To investigate the effects of dexamethasone on the expression of interleukin-21 (IL-21) and phospho- STAT3 (p-STAT3) in a murine model of chronic asthma.	Dexamethasone	41-54	signal transducer and activator of transcription 3	Mus musculus	121-126
23688998-7	2013	Compared with the control group, the asthmatic group showed significantly increased protein expressions of IL-21 and p-STAT3 (P<0.05), which were reduced by dexamethasone intervention (P/0.05).	Dexamethasone	160-173	signal transducer and activator of transcription 3	Mus musculus	119-124
23688998-8	2013	CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma.	Dexamethasone	12-25	signal transducer and activator of transcription 3	Mus musculus	68-73
23688998-8	2013	CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma.	Dexamethasone	12-25	signal transducer and activator of transcription 3	Mus musculus	148-153
23688998-8	2013	CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma.	Dexamethasone	205-218	signal transducer and activator of transcription 3	Mus musculus	68-73
23688998-8	2013	CONCLUSION: Dexamethasone can inhibit the expression of IL-21 and p-STAT3 in the murine model of chronic asthma, suggesting the importance of IL-21/STAT3 signaling pathway in the therapeutic mechanisms of dexamethasone for asthma.	Dexamethasone	205-218	signal transducer and activator of transcription 3	Mus musculus	148-153
23376140-2	2013	A link between this heavy metal treatment and Stat3 signaling pathways was examined in primary mouse hepatocytes.	Metals	26-31	signal transducer and activator of transcription 3	Mus musculus	46-51
23376140-5	2013	ROS produced by this oxidase activates Src, enable that in turn, transactivates EGFR that activates Stat3 in tyrosine, allowing its dimerization.	ros	0-3	signal transducer and activator of transcription 3	Mus musculus	100-105
23376140-5	2013	ROS produced by this oxidase activates Src, enable that in turn, transactivates EGFR that activates Stat3 in tyrosine, allowing its dimerization.	Tyrosine	109-117	signal transducer and activator of transcription 3	Mus musculus	100-105
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	ros	6-9	signal transducer and activator of transcription 3	Mus musculus	74-79
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	Serine	83-89	signal transducer and activator of transcription 3	Mus musculus	74-79
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	Cadmium	199-201	signal transducer and activator of transcription 3	Mus musculus	74-79
23557965-10	2013	Metformin treatment of normal cells cultured in Th17-differentiation-inducing conditions decreased the number of RORgammat-expressing CD4+ cells in a dose-dependent manner and downregulated STAT3 phosphorylation via the AMPK pathway.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	190-195
23064699-5	2013	These effects, in turn, may be mediated by EGCG-induced downregulation of transducers p-STAT1 and p-STAT4 for Th1, and p-STAT3 for Th17.	epigallocatechin gallate	43-47	signal transducer and activator of transcription 3	Mus musculus	121-126
23064699-6	2013	EGCG-induced change in Th17/Treg balance may be mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6-induced phosphorylation of STAT3.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	183-188
23064699-6	2013	EGCG-induced change in Th17/Treg balance may be mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6-induced phosphorylation of STAT3.	epigallocatechin gallate	101-105	signal transducer and activator of transcription 3	Mus musculus	183-188
23266654-5	2013	AG490, a specific inhibitor of JAK2, inhibited the expression of p21 and degradation of cyclin D1 in A. actinomycetemcomitans-infected RAW 264.7 cells, resulting in suppression of STAT3 phosphorylation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	180-185
23360889-5	2013	However, surfactin increases the phosphorylation of the STAT-3, a component of the homeostatic mechanism causing anti-inflammatory events.	surfactin peptide	9-18	signal transducer and activator of transcription 3	Mus musculus	56-62
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	Flavonoids	155-164	signal transducer and activator of transcription 3	Mus musculus	62-67
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	Glucosides	165-174	signal transducer and activator of transcription 3	Mus musculus	62-67
23261528-0	2013	Inhibition of Th1/Th17 responses via suppression of STAT1 and STAT3 activation contributes to the amelioration of murine experimental colitis by a natural flavonoid glucoside icariin.	icariin	175-182	signal transducer and activator of transcription 3	Mus musculus	62-67
23261528-8	2013	Moreover, icariin treatment inhibited the phosphorylations of STAT1 and STAT3 in CD4(+) T cells, which were the crucial transcription factors for Th1 and Th17 respectively.	icariin	10-17	signal transducer and activator of transcription 3	Mus musculus	72-77
23425941-0	2013	Functional graphene oxide as a plasmid-based Stat3 siRNA carrier inhibits mouse malignant melanoma growth in vivo.	graphene oxide	11-25	signal transducer and activator of transcription 3	Mus musculus	45-50
23425941-4	2013	In this paper, we study the in vivo behavior of graphene oxide chemically functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) as a plasmid-based Stat3-specific small interfering RNA (siRNA) carrier in mouse malignant melanoma.	graphene oxide	48-62	signal transducer and activator of transcription 3	Mus musculus	167-172
23425941-4	2013	In this paper, we study the in vivo behavior of graphene oxide chemically functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) as a plasmid-based Stat3-specific small interfering RNA (siRNA) carrier in mouse malignant melanoma.	Polyethyleneimine	94-110	signal transducer and activator of transcription 3	Mus musculus	167-172
23425941-4	2013	In this paper, we study the in vivo behavior of graphene oxide chemically functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) as a plasmid-based Stat3-specific small interfering RNA (siRNA) carrier in mouse malignant melanoma.	Polyethylene Glycols	115-134	signal transducer and activator of transcription 3	Mus musculus	167-172
23425941-4	2013	In this paper, we study the in vivo behavior of graphene oxide chemically functionalized with polyethylenimine and polyethylene glycol (GO-PEI-PEG) as a plasmid-based Stat3-specific small interfering RNA (siRNA) carrier in mouse malignant melanoma.	go-pei-peg	136-146	signal transducer and activator of transcription 3	Mus musculus	167-172
23425941-5	2013	The in vivo results indicate significant regression in tumor growth and tumor weight after plasmid-based Stat3 siRNA delivered by GO-PEI-PEG treatment.	go-pei-peg	130-140	signal transducer and activator of transcription 3	Mus musculus	105-110
23425941-7	2013	Thus, our work is the first success of using GO-PEI-PEG as a promising carrier for plasmid Stat3 siRNA delivery and down-regulation of Stat3 by a polymer-mediated vehicle and suggests the great promise of graphene in biomedical applications such as cancer treatment.	go-pei-peg	45-55	signal transducer and activator of transcription 3	Mus musculus	91-96
23425941-7	2013	Thus, our work is the first success of using GO-PEI-PEG as a promising carrier for plasmid Stat3 siRNA delivery and down-regulation of Stat3 by a polymer-mediated vehicle and suggests the great promise of graphene in biomedical applications such as cancer treatment.	go-pei-peg	45-55	signal transducer and activator of transcription 3	Mus musculus	135-140
23425941-7	2013	Thus, our work is the first success of using GO-PEI-PEG as a promising carrier for plasmid Stat3 siRNA delivery and down-regulation of Stat3 by a polymer-mediated vehicle and suggests the great promise of graphene in biomedical applications such as cancer treatment.	Polymers	146-153	signal transducer and activator of transcription 3	Mus musculus	135-140
23425941-7	2013	Thus, our work is the first success of using GO-PEI-PEG as a promising carrier for plasmid Stat3 siRNA delivery and down-regulation of Stat3 by a polymer-mediated vehicle and suggests the great promise of graphene in biomedical applications such as cancer treatment.	Graphite	205-213	signal transducer and activator of transcription 3	Mus musculus	91-96
23425941-7	2013	Thus, our work is the first success of using GO-PEI-PEG as a promising carrier for plasmid Stat3 siRNA delivery and down-regulation of Stat3 by a polymer-mediated vehicle and suggests the great promise of graphene in biomedical applications such as cancer treatment.	Graphite	205-213	signal transducer and activator of transcription 3	Mus musculus	135-140
22614008-4	2013	This nicotine-mediated MUC4 overexpression was via the alpha7 subunit of nicotinic acetylcholine receptor (nAChR) stimulation and subsequent activation of the JAK2/STAT3 downstream signaling cascade in cooperation with the MEK/ERK1/2 pathway; this effect was blocked by the alpha7nAChR antagonists, alpha-bungarotoxin and mecamylamine, and by specific siRNA-mediated STAT3 inhibition.	Nicotine	5-13	signal transducer and activator of transcription 3	Mus musculus	164-169
22614008-4	2013	This nicotine-mediated MUC4 overexpression was via the alpha7 subunit of nicotinic acetylcholine receptor (nAChR) stimulation and subsequent activation of the JAK2/STAT3 downstream signaling cascade in cooperation with the MEK/ERK1/2 pathway; this effect was blocked by the alpha7nAChR antagonists, alpha-bungarotoxin and mecamylamine, and by specific siRNA-mediated STAT3 inhibition.	Nicotine	5-13	signal transducer and activator of transcription 3	Mus musculus	367-372
22614008-8	2013	Altogether, our findings revealed for the first time that CS upregulates the MUC4 mucin in PC via the alpha7nAChR/JAK2/STAT3 downstream signaling cascade, thereby promoting metastasis of PC.	Cesium	58-60	signal transducer and activator of transcription 3	Mus musculus	119-124
23298456-10	2013	Moreover, GA treatment enhanced phosphorylation of signal transducer and activator of transcription 3.	geniposidic acid	10-12	signal transducer and activator of transcription 3	Mus musculus	51-101
23239498-7	2013	Moreover, in vivo DUOX1 silencing significantly suppressed naphthalene-induced activation of STAT3 and EGFR during early stages of epithelial repair.	naphthalene	59-70	signal transducer and activator of transcription 3	Mus musculus	93-98
23429443-0	2013	Deletion of intestinal epithelial cell STAT3 promotes T-lymphocyte STAT3 activation and chronic colitis following acute dextran sodium sulfate injury in mice.	dextran sodium sulfate	120-142	signal transducer and activator of transcription 3	Mus musculus	39-44
23429443-1	2013	BACKGROUND: Intestinal epithelial cell (IEC) STAT3 is required for wound healing following acute dextran sodium sulfate (DSS) injury.	dextran sodium sulfate	97-119	signal transducer and activator of transcription 3	Mus musculus	45-50
23429443-1	2013	BACKGROUND: Intestinal epithelial cell (IEC) STAT3 is required for wound healing following acute dextran sodium sulfate (DSS) injury.	dss	121-124	signal transducer and activator of transcription 3	Mus musculus	45-50
23429443-11	2013	CONCLUSIONS: Loss of intestinal epithelial STAT3 leads to more severe chronic inflammation following acute injury, which is not accounted for by a sustained defect in epithelial proliferation or apoptosis 7 or 21 days after 1 cycle of DSS but rather defective REG3 expression and expansion of pSTAT3* lymphocytes and IL-17A expression.	dss	235-238	signal transducer and activator of transcription 3	Mus musculus	43-48
23531921-0	2013	Inhibition of STAT3 with orally active JAK inhibitor, AZD1480, decreases tumor growth in Neuroblastoma and Pediatric Sarcomas In vitro and In vivo.	AZD 1480	54-61	signal transducer and activator of transcription 3	Mus musculus	14-19
23531921-5	2013	Our data indicate that AZD1480 blocks endogenous as well as IL-6 induced STAT3 activation.	AZD 1480	23-30	signal transducer and activator of transcription 3	Mus musculus	73-78
23531921-7	2013	AZD1480 induces cell growth inhibition and caspase-dependent apoptosis in vitro and decreases expression of STAT3 target genes, including cell cycle regulators CyclinD1, 3 and CDC25A, anti-apoptotic genes Bcl-2 and survivin, the metastasis-related factor TIMP-1 and c-Myc.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	108-113
23531921-9	2013	Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets.	AZD 1480	12-19	signal transducer and activator of transcription 3	Mus musculus	64-69
23531921-9	2013	Tumors from AZD1480-treated mice showed inhibition of activated STAT3 as well as decreased expression of STAT3 downstream targets.	AZD 1480	12-19	signal transducer and activator of transcription 3	Mus musculus	105-110
23531921-10	2013	Our study provides strong evidence of the anti-tumor growth potency of JAK inhibitor AZD1480 in pediatric solid tumors, providing proof-of principle that inhibition of the JAK/STAT3 signal transduction could be a promising therapeutic target for high-risk pediatric solid tumors.	AZD 1480	85-92	signal transducer and activator of transcription 3	Mus musculus	176-181
23511693-11	2013	Treatment through intrathecal injection of AG490, an inhibitor of the JAK2/STAT3 pathway, alleviated mechanical hyperalgesia in ob/ob mice and prevented impaired insulin signaling in the spinal cord.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	43-48	signal transducer and activator of transcription 3	Mus musculus	75-80
23406906-1	2013	INTRODUCTION: This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-kappaB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus activated kinase (JAK2)/signal transducer and activator of transcription-3 (STAT3) and suppressor of cytokine signaling (SOCS3) signaling.	Tacrolimus	73-83	signal transducer and activator of transcription 3	Mus musculus	249-299
23374901-14	2013	Significantly increased STAT3 phosphorylation at Ser727 was observed with hypothermia, and JSI-124, a STAT-3 inhibitor, suppressed MT expression.	cucurbitacin I	91-98	signal transducer and activator of transcription 3	Mus musculus	102-108
23406906-1	2013	INTRODUCTION: This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-kappaB ligand (RANKL) expression in fibroblast-like synoviocytes (FLS) through regulation of IL-6/Janus activated kinase (JAK2)/signal transducer and activator of transcription-3 (STAT3) and suppressor of cytokine signaling (SOCS3) signaling.	Tacrolimus	73-83	signal transducer and activator of transcription 3	Mus musculus	301-306
23406906-8	2013	Tacrolimus inhibits RANKL expression in IL-6/sIL-6R-stimulated FLS by suppressing STAT3.	Tacrolimus	0-10	signal transducer and activator of transcription 3	Mus musculus	82-87
23406906-12	2013	CONCLUSIONS: These data suggest that tacrolimus might affect the RANKL expression in IL-6 stimulated FLS through STAT3 suppression, together with up-regulation of SOCS3.	Tacrolimus	37-47	signal transducer and activator of transcription 3	Mus musculus	113-118
22875246-0	2013	Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid cholangiocarcinoma.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	62-67
22875246-5	2013	Prolonged treatments with rapamycin were found to disrupt the mTORC2 assembly and to reduce the phosphorylation of STAT3 at Ser 727.	Serine	124-127	signal transducer and activator of transcription 3	Mus musculus	115-120
22875246-7	2013	The overexpression of STAT3 S727A lacking the phosphorylation site resulted in significantly less sensitivity to rapamycin than the overexpression of STAT3 WT.	Sirolimus	113-122	signal transducer and activator of transcription 3	Mus musculus	22-27
23306703-6	2013	Additionally, ASA, but not salicylic acid, suppressed Th17 airway inflammation, which was associated with decreased expression of acetyl-STAT3 (downstream signaling of IL-6) in the lung.	Aspirin	14-17	signal transducer and activator of transcription 3	Mus musculus	137-142
23143138-0	2013	Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells.	sodium arsenite	0-15	signal transducer and activator of transcription 3	Mus musculus	42-47
23143138-5	2013	Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure.	sodium arsenite	168-183	signal transducer and activator of transcription 3	Mus musculus	99-104
23143138-8	2013	In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways.	sodium arsenite	105-120	signal transducer and activator of transcription 3	Mus musculus	223-228
23178521-0	2013	Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.	anatabine	30-39	signal transducer and activator of transcription 3	Mus musculus	58-63
23114963-4	2013	In differentiating C2C12 myoblasts, the upregulation of IL-6 mRNA expression and protein secretion started after increased phosphorylation of STAT3 on tyrosine 705 and increased mRNA expression of Socs3 was observed.	Tyrosine	151-159	signal transducer and activator of transcription 3	Mus musculus	142-147
23178521-6	2013	We observed that anatabine reduces pro-inflammatory cytokine production (IL-6, IL-1beta and TNF-alpha) in the plasma, kidney and spleen of the animals following the injection of LPS and concomitantly opposes STAT3 phosphorylation induced by LPS in the spleen and kidney.	anatabine	17-26	signal transducer and activator of transcription 3	Mus musculus	208-213
23178521-9	2013	Moreover, an increased STAT3 phosphorylation was detected in the brains of Tg APPsw mice compared to wild-type littermates and was inhibited by anatabine treatment.	anatabine	144-153	signal transducer and activator of transcription 3	Mus musculus	23-28
23178521-10	2013	Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation.	anatabine	61-70	signal transducer and activator of transcription 3	Mus musculus	133-138
23737822-13	2013	Consistently, oral administration of kaempferol blocked STAT3 transactivation elevated by OVA challenge.	kaempferol	37-47	signal transducer and activator of transcription 3	Mus musculus	56-61
23439558-5	2013	Moreover, although the Gfap promoter region containing the STAT3-binding site (GSBS) is enriched with transcription-repressive histone modifications, such as methylation of H3 at lysine 9 (H3K9me3) and H3K27me3, the reduction of these modifications in TKO ESCs was not sufficient for binding of STAT3 at GSBS.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	59-64
23257358-8	2013	Consequently, the ability of IL-13 to suppress glucose production was abolished in liver cells lacking Stat3 or IL-13 receptor alpha1 (Il-13ralpha1), which suggests that the IL-13Ralpha1/Stat3 axis directs IL-13 signaling toward metabolic responses.	Glucose	47-54	signal transducer and activator of transcription 3	Mus musculus	187-192
22819551-6	2013	In addition, EGCG also attenuated TNF-alpha-induced oxidative stress, p47(phox) translocation, MAPKs activation, and STAT-3 and activating transcription factor (ATF)2 phosphorylation.	epigallocatechin gallate	13-17	signal transducer and activator of transcription 3	Mus musculus	117-123
22772901-0	2013	Protective effect of carbamazepine on kainic acid-induced neuronal cell death through activation of signal transducer and activator of transcription-3.	Carbamazepine	21-34	signal transducer and activator of transcription 3	Mus musculus	100-150
22772901-0	2013	Protective effect of carbamazepine on kainic acid-induced neuronal cell death through activation of signal transducer and activator of transcription-3.	Kainic Acid	38-49	signal transducer and activator of transcription 3	Mus musculus	100-150
22772901-5	2013	Through microarray analysis, we found that signal transducer and activator of transcription-3 (Stat3) gene expression was upregulated in the hippocampal CA3 region, 24 h after KA injection (15 mg/kg), and that CBZ further elevated Stat3 expression in KA-treated mice.	Carbamazepine	210-213	signal transducer and activator of transcription 3	Mus musculus	43-93
22772901-5	2013	Through microarray analysis, we found that signal transducer and activator of transcription-3 (Stat3) gene expression was upregulated in the hippocampal CA3 region, 24 h after KA injection (15 mg/kg), and that CBZ further elevated Stat3 expression in KA-treated mice.	Carbamazepine	210-213	signal transducer and activator of transcription 3	Mus musculus	95-100
22772901-5	2013	Through microarray analysis, we found that signal transducer and activator of transcription-3 (Stat3) gene expression was upregulated in the hippocampal CA3 region, 24 h after KA injection (15 mg/kg), and that CBZ further elevated Stat3 expression in KA-treated mice.	Carbamazepine	210-213	signal transducer and activator of transcription 3	Mus musculus	231-236
22772901-7	2013	In particular, phospho-Stat3 immunoreactivity (IR) by KA was shown in astrocytes rather than in neurons; whereas phospho-Stat3 IR by CBZ in KA-treated mice was observed predominantly in neurons, and also in neuroprotective protein Bcl-xL-expression cells.	Carbamazepine	133-136	signal transducer and activator of transcription 3	Mus musculus	121-126
22772901-8	2013	These results indicate that Stat3 may play an important role in neuroprotective action of CBZ on seizure-induced neuronal injury.	Carbamazepine	90-93	signal transducer and activator of transcription 3	Mus musculus	28-33
23781122-8	2013	Further studies showed that GW405833 inhibits LPS-induced phosphorylation of ERK1/2 and STAT3 and blocks I kappa B alpha degradation and NF- kappaB p65 nuclear translocation in macrophages.	1-(2,3-dichlorobenzoyl)-5-methoxy-2-methyl-(2-(mopholin-4-yl)ethyl)-1H-indole	28-36	signal transducer and activator of transcription 3	Mus musculus	88-93
23065380-11	2013	The activations of mitogen-activated protein kinase extracellular signal-regulated kinases, Akt, GSK3beta and STAT3 induced by PDGF-BB were also inhibited in sinomenine-treated VSMCs.	sinomenine	158-168	signal transducer and activator of transcription 3	Mus musculus	110-115
24204098-7	2013	STAT3KO mice are also resistant to EAU and produced less IL-17-producing Tc17 cells.	Water	35-38	signal transducer and activator of transcription 3	Mus musculus	0-5
23383175-6	2013	Anatabine appears to significantly suppress STAT3 and p65 NFkappaB phosphorylation in the spleen and the brain of EAE mice.	anatabine	0-9	signal transducer and activator of transcription 3	Mus musculus	44-49
23825949-11	2013	In vivo neutralization of IL-6 by anti-IL-6 antibody, STAT3 by siRNA, and fibrin by warfarin treatment, respectively, demonstrated that IL-6-induced, STAT3-mediated fibrin production significantly contributed to protection in Cyld(-/-) mice.	Warfarin	84-92	signal transducer and activator of transcription 3	Mus musculus	150-155
23399843-5	2012	Furthermore, veratric acid facilitated the inactivation of glycogen synthase kinase-3beta (GSK-3beta), STAT-1, and STAT-3 in dose-dependent manner.	veratric acid	13-26	signal transducer and activator of transcription 3	Mus musculus	115-121
23036579-0	2012	Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-kappaB pathways.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	108-113
23036579-0	2012	Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-kappaB pathways.	andrographolide sulfonate	14-39	signal transducer and activator of transcription 3	Mus musculus	108-113
23036579-7	2012	Furthermore, pretreatment with andrographolide sulfonate markedly inhibited the activation of p65 subunit of nuclear factor-kappaB (NF-kappaB) as well as signal transducers and activators of transcription 3 (STAT3) in the injured liver from mice with endotoxic shock.	andrographolide sulfonate	31-56	signal transducer and activator of transcription 3	Mus musculus	154-206
23036579-7	2012	Furthermore, pretreatment with andrographolide sulfonate markedly inhibited the activation of p65 subunit of nuclear factor-kappaB (NF-kappaB) as well as signal transducers and activators of transcription 3 (STAT3) in the injured liver from mice with endotoxic shock.	andrographolide sulfonate	31-56	signal transducer and activator of transcription 3	Mus musculus	208-213
23036579-9	2012	Taken together, these results reveal that andrographolide sulfonate ameliorates sepsis in mice through suppressing p38 MAPK, STAT3 and NF-kappaB pathways and suggest that andrographolide sulfonate has an advantage of andrographolide for the treatment of endotoxin shock.	andrographolide sulfonate	42-67	signal transducer and activator of transcription 3	Mus musculus	125-130
23036579-9	2012	Taken together, these results reveal that andrographolide sulfonate ameliorates sepsis in mice through suppressing p38 MAPK, STAT3 and NF-kappaB pathways and suggest that andrographolide sulfonate has an advantage of andrographolide for the treatment of endotoxin shock.	andrographolide	42-57	signal transducer and activator of transcription 3	Mus musculus	125-130
22999860-0	2012	Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	79-84
22999860-12	2012	In situ knock-down of STAT3 attenuated rapamycin-induced protection against I/R injury.	Sirolimus	39-48	signal transducer and activator of transcription 3	Mus musculus	22-27
22999860-13	2012	Rapamycin triggered unique cardioprotective signaling including phosphorylation of ERK, STAT3, eNOS and glycogen synthase kinase-3ss in concert with increased prosurvival Bcl-2 to Bax ratio.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	88-93
22999860-15	2012	We propose that rapamycin is a novel and clinically relevant pharmacological strategy to target STAT3 activation for treatment of myocardial infarction.	Sirolimus	16-25	signal transducer and activator of transcription 3	Mus musculus	96-101
23140643-3	2012	The decreased CES3 expression was accomplished by TCDD-stimulated TGFbeta-SMAD3 and IL6-STAT3 signaling, but not by direct AhR signaling.	Polychlorinated Dibenzodioxins	50-54	signal transducer and activator of transcription 3	Mus musculus	88-93
23169551-8	2013	We showed that this crosstalk was effectively blocked by the small molecule inhibitors AG1478 or CDDO-Im against EGFR and Stat3, respectively.	RTKI cpd	87-93	signal transducer and activator of transcription 3	Mus musculus	122-127
23169551-8	2013	We showed that this crosstalk was effectively blocked by the small molecule inhibitors AG1478 or CDDO-Im against EGFR and Stat3, respectively.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	97-104	signal transducer and activator of transcription 3	Mus musculus	122-127
23533666-6	2013	IL-10 secreted in response to zymosan was able to promote STAT3 phosphorylation via an autocrine feedback loop.	Zymosan	30-37	signal transducer and activator of transcription 3	Mus musculus	58-63
23342059-6	2013	MS-275 was also effective in suppressing phosphorylation and expression of epidermal growth factor receptor (EGFR) and its downstream signaling molecule, signal transducer and activator of transcription-3.	entinostat	0-6	signal transducer and activator of transcription 3	Mus musculus	154-204
23064197-0	2012	Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction.	Ceruletide	39-48	signal transducer and activator of transcription 3	Mus musculus	11-16
23064197-4	2012	Caerulein administration activated pancreatic STAT3 and induced acute pancreatitis as early as 3 hours in wild-type mice, and full recovery from the induced pancreatic injury was observed within 7 days.	Ceruletide	0-9	signal transducer and activator of transcription 3	Mus musculus	46-51
22971573-0	2012	Anticancer action of garcinol in vitro and in vivo is in part mediated through inhibition of STAT-3 signaling.	garcinol	21-29	signal transducer and activator of transcription 3	Mus musculus	93-99
22971573-4	2012	Here we show that garcinol also targets signal transducer and activator of transcription-3 (STAT-3) signaling pathway.	garcinol	18-26	signal transducer and activator of transcription 3	Mus musculus	40-90
22971573-4	2012	Here we show that garcinol also targets signal transducer and activator of transcription-3 (STAT-3) signaling pathway.	garcinol	18-26	signal transducer and activator of transcription 3	Mus musculus	92-98
22971573-5	2012	STAT-3 is frequently found to be activated in many cancer types and this is the first report on such action of garcinol leading to its anticancer effects.	garcinol	111-119	signal transducer and activator of transcription 3	Mus musculus	0-6
22971573-6	2012	Garcinol inhibited total, as well as phosphorylated, STAT-3 in breast, prostate and pancreatic cancer cell lines and was also found to inhibit cell invasion of all the cancer cell lines tested.	garcinol	0-8	signal transducer and activator of transcription 3	Mus musculus	53-59
22971573-7	2012	STAT-3 phosphorylation was inhibited by garcinol in a dose-dependent manner.	garcinol	40-48	signal transducer and activator of transcription 3	Mus musculus	0-6
22971573-8	2012	We also observed an inhibitory effect of garcinol on IL-6-induced STAT-3 phosphorylation and production of urokinase-type plasminogen activator, vascular endothelial growth factor and matrix metalloproteinase-9, which might explain the reduced invasion and aggressiveness of cells treated with garcinol.	garcinol	41-49	signal transducer and activator of transcription 3	Mus musculus	66-72
22971573-9	2012	The results were further verified in vivo using MDA-MB-231 breast cancer mouse xenograft model where administration of garcinol significantly inhibited tumor growth, and western blot analysis of remnant tumor lysates showed reduced STAT-3 expression and activation.	garcinol	119-127	signal transducer and activator of transcription 3	Mus musculus	232-238
22971573-10	2012	These results suggest that garcinol may have translational potential as chemopreventive or therapeutic agent against multiple cancers and inhibition of STAT-3 signaling pathway is one of the mechanisms by which garcinol exerts its anticancer effects.	garcinol	211-219	signal transducer and activator of transcription 3	Mus musculus	152-158
22922424-13	2012	CONCLUSIONS: Sorafenib promotes invasiveness and the metastatic potential of orthotopic tumors from HCC cells in mice, down-regulating expression of HTATIP2 via JAK-STAT3 signaling.	Sorafenib	13-22	signal transducer and activator of transcription 3	Mus musculus	165-170
22711600-10	2012	Besides suppressing the activation of STAT3, STAT5 induces the expression of proapoptotic genes and the production of ROS.	Reactive Oxygen Species	118-121	signal transducer and activator of transcription 3	Mus musculus	38-43
22902832-0	2012	Rebuilding the balance of STAT1 and STAT3 signalings by fusaruside, a cerebroside compound, for the treatment of T-cell-mediated fulminant hepatitis in mice.	Cerebrosides	70-81	signal transducer and activator of transcription 3	Mus musculus	36-41
22992748-2	2012	We discovered that skin tumors derived from epidermal expression of oncogenic Smo, SmoM2, have elevated levels of IL-11, IL-11Ralpha, and STAT3 phosphorylation at Tyr(705).	Tyrosine	163-166	signal transducer and activator of transcription 3	Mus musculus	138-143
22992748-10	2012	In two Hh-responsive cell lines, ES14 and C3H10T1/2, we found that addition of Smo agonist purmorphamine is sufficient to induce STAT3 phosphorylation at Tyr(705), but this effect was abolished after IL-11Ralpha down-regulation by shRNAs.	purmorphamine	91-104	signal transducer and activator of transcription 3	Mus musculus	129-134
22992748-10	2012	In two Hh-responsive cell lines, ES14 and C3H10T1/2, we found that addition of Smo agonist purmorphamine is sufficient to induce STAT3 phosphorylation at Tyr(705), but this effect was abolished after IL-11Ralpha down-regulation by shRNAs.	Tyrosine	154-157	signal transducer and activator of transcription 3	Mus musculus	129-134
22902832-6	2012	Furthermore, the protective effect of fusaruside was attributable to a novel regulatory mechanism through down-regulating STAT1 activation and T-bet expression in liver CD4(+) T cells and up-regulating STAT3 activation and Bcl-X(L) expression in hepatocytes.	fusaruside	38-48	signal transducer and activator of transcription 3	Mus musculus	202-207
22907754-6	2012	Notably, the JAK-STAT pathway is altered by KLF4, with increased phosphorylation of STAT3 at tyrosine 705.	Tyrosine	93-101	signal transducer and activator of transcription 3	Mus musculus	84-89
22841822-11	2012	Leptin also normalized alcohol-reduced phosphorylation levels of signal transducer Stat3 and adenosine monophosphate-activated protein kinase.	Alcohols	23-30	signal transducer and activator of transcription 3	Mus musculus	83-88
22531980-8	2012	In agreement with these observations, in vitro experiments showed that in the presence of leptin, ATRA directly induced LEPR gene expression through RARalpha, resulting in enhancement of STAT3 and insulin-induced insulin receptor substrate 1 phosphorylation.	Tretinoin	98-102	signal transducer and activator of transcription 3	Mus musculus	187-192
22531980-9	2012	A selective RARalpha/beta agonist, Am80, also enhanced hepatic LEPR expression and STAT3 phosphorylation and ameliorated insulin resistance in KK-A(y) mice.	tamibarotene	35-39	signal transducer and activator of transcription 3	Mus musculus	83-88
23226098-12	2012	Confocal microscopy images exhibit a decreased rate of AR/STAT3 nuclear co-localization under hemin treatment.	Hemin	94-99	signal transducer and activator of transcription 3	Mus musculus	58-63
22847137-0	2012	Arecoline inhibits myogenic differentiation of C2C12 myoblasts by reducing STAT3 phosphorylation.	Arecoline	0-9	signal transducer and activator of transcription 3	Mus musculus	75-80
22847137-8	2012	Moreover, phosphorylated but not total STAT3 was significantly inhibited by arecoline during myotube formation.	Arecoline	76-85	signal transducer and activator of transcription 3	Mus musculus	39-44
22847137-9	2012	These results indicate that arecoline inhibits the myogenic differentiation of C2C12 cells by reducing the activation of STAT3, an upstream regulator of myogenesis.	Arecoline	28-37	signal transducer and activator of transcription 3	Mus musculus	121-126
21882257-7	2012	Importantly, silibinin pretreatment inhibited cytokine mixture-induced phosphorylation of STAT3, STAT1, and Erk1/2, NF-kappaB-DNA binding, and expression of COX2, iNOS, matrix metalloproteinases (MMP)2, and MMP9, which was mediated through impairment of STAT3 and STAT1 nuclear localization.	Silybin	13-22	signal transducer and activator of transcription 3	Mus musculus	90-95
21882257-7	2012	Importantly, silibinin pretreatment inhibited cytokine mixture-induced phosphorylation of STAT3, STAT1, and Erk1/2, NF-kappaB-DNA binding, and expression of COX2, iNOS, matrix metalloproteinases (MMP)2, and MMP9, which was mediated through impairment of STAT3 and STAT1 nuclear localization.	Silybin	13-22	signal transducer and activator of transcription 3	Mus musculus	254-259
22797782-10	2012	PR39 and Stat3 siRNA             displayed synergistic biological effects in inhibiting cell invasion and migration             of 4T1 cells, which was more prominent compared with the popular Lipofectamine             delivery system.	Lipofectamine	193-206	signal transducer and activator of transcription 3	Mus musculus	9-14
22956616-8	2012	RESULTS: It was demonstrated that several inhibitors of ROS greatly reduce the levels of pERK1/2 in the somata of Muller cells and furthermore decrease two other downstream signaling events: the phosphorylation of STAT3 and the upregulation of basic fibroblast growth factor.	Reactive Oxygen Species	56-59	signal transducer and activator of transcription 3	Mus musculus	214-219
22922441-7	2012	In vitro, SAHA reduced the proportion of Th17 cells in isolated CD4+ T-cell population and decreased expressions of IL-17A, IL-17F, STAT3 and RORgammat in these cells.	Vorinostat	10-14	signal transducer and activator of transcription 3	Mus musculus	132-137
22665934-5	2012	We found that STAT3(-/-) mice, which have a very shortened lifespan, dysfunctional/dysregulated mitochondrial function and excessive reactive oxygen species production in HSCs/HPCs that coincides with pronounced defects in function.	Reactive Oxygen Species	133-156	signal transducer and activator of transcription 3	Mus musculus	14-19
22797328-0	2012	Involvement of STAT3, NF-kappaB and associated downstream molecules before and after the onset of urethane induced lung tumors in mouse.	Urethane	98-106	signal transducer and activator of transcription 3	Mus musculus	15-20
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	119-126	signal transducer and activator of transcription 3	Mus musculus	30-35
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	119-126	signal transducer and activator of transcription 3	Mus musculus	55-60
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	119-126	signal transducer and activator of transcription 3	Mus musculus	174-179
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	201-208	signal transducer and activator of transcription 3	Mus musculus	30-35
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	201-208	signal transducer and activator of transcription 3	Mus musculus	55-60
22660795-9	2012	Furthermore, knockdown of the Stat3 gene or inhibiting STAT3 activity restored ER homeostasis in cells exposed to high glucose and prevented ATF4 activation, suggesting that STAT3 is required for high-glucose-induced ER stress.	Glucose	201-208	signal transducer and activator of transcription 3	Mus musculus	174-179
22156994-0	2012	Curcumin:  a novel Stat3 pathway inhibitor for chemoprevention of lung cancer.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	19-24
22156994-2	2012	On the basis of the existing evidence, we hypothesized that bioavailable curcuminoid complex may modulate lung carcinogenesis, primarily by inhibiting Stat3 activation.	curcuminoid	73-84	signal transducer and activator of transcription 3	Mus musculus	151-156
22156994-8	2012	In-vitro studies with curcuminoid complex demonstrated that the activity of Stat3 in both normal bronchoepithelial cells and lung cancer-derived cells is sensitive to curcumin exposure.	curcuminoid	22-33	signal transducer and activator of transcription 3	Mus musculus	76-81
22156994-8	2012	In-vitro studies with curcuminoid complex demonstrated that the activity of Stat3 in both normal bronchoepithelial cells and lung cancer-derived cells is sensitive to curcumin exposure.	Curcumin	22-30	signal transducer and activator of transcription 3	Mus musculus	76-81
22156994-9	2012	In a dose-dependent manner, curcumin treatment resulted in significant suppression of Stat3 phosphorylation and reduction in the proliferative capacity of both cell types.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	86-91
22156994-10	2012	In the preclinical trial with rodent models, curcumin reduced Stat3-P and the proliferative markers CycD1 and Mcm2 in mice lung tissues in vivo.	Curcumin	45-53	signal transducer and activator of transcription 3	Mus musculus	62-67
22797328-1	2012	Here we have shown the alteration of transcription factors STAT3, NF-kappaB and downstream associated molecules much before the appearance of lung tumor and their response to antitumor agent, inositol hexaphosphate.	Phytic Acid	192-214	signal transducer and activator of transcription 3	Mus musculus	59-64
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	107-115	signal transducer and activator of transcription 3	Mus musculus	72-77
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	107-115	signal transducer and activator of transcription 3	Mus musculus	228-233
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	295-303	signal transducer and activator of transcription 3	Mus musculus	72-77
22751848-7	2012	The induction of signal transducer and activator of transcription 3 phosphorylation by curcumin resulted in the downregulation of the suppressor of cytokine signaling 3 in the liver of obese mice.	Curcumin	87-95	signal transducer and activator of transcription 3	Mus musculus	17-67
22156994-11	2012	These culture and preclinical studies indicate that the activity of the Stat3 pathway can be suppressed by curcumin treatment, concomitant with a reduction in cell proliferation, supporting our hypothesis that inhibition of the Stat3 pathway represents at least one important mechanism by which curcumin elicits its effects on the bronchoepithelium.	Curcumin	295-303	signal transducer and activator of transcription 3	Mus musculus	228-233
23118721-8	2012	Most importantly, fucoxanthin inhibited the expressions of the epidermal growth factor receptor (EGFR) and STAT3 and phosphorylated STAT3 proteins.	fucoxanthin	18-29	signal transducer and activator of transcription 3	Mus musculus	107-112
23118721-8	2012	Most importantly, fucoxanthin inhibited the expressions of the epidermal growth factor receptor (EGFR) and STAT3 and phosphorylated STAT3 proteins.	fucoxanthin	18-29	signal transducer and activator of transcription 3	Mus musculus	132-137
23118721-0	2012	In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice.	fucoxanthin	34-45	signal transducer and activator of transcription 3	Mus musculus	100-105
23118721-9	2012	These results indicated that in vivo induction of apoptosis by fucoxanthin is associated with down-regulating STAT3/EGFR signaling in S180 xenografts-bearing mice.	fucoxanthin	63-74	signal transducer and activator of transcription 3	Mus musculus	110-115
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p < 0.05).	dss	38-41	signal transducer and activator of transcription 3	Mus musculus	185-190
22909126-9	2012	Exercise was also found to significantly decrease the phosphorylation expression of STAT3 in both WT and APNKO mice in DSS + EX group when compared to DSS + SED.	dss	119-122	signal transducer and activator of transcription 3	Mus musculus	84-89
25436678-0	2012	From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities.	Glucose	24-31	signal transducer and activator of transcription 3	Mus musculus	64-114
22581828-10	2012	The N1IC-promoted tumor growth and lung metastasis of SC-M1 cells in mice were suppressed by the STAT3 inhibitor JSI-124 and Twist knockdown.	cucurbitacin I	113-120	signal transducer and activator of transcription 3	Mus musculus	97-102
22541355-5	2012	Under nanopattern PDMS conditions, we found increased activities of STAT3 and Akt, important proteins involved in maintaining the self-renewal of mES cells.	2-(N-morpholino)ethanesulfonic acid	146-149	signal transducer and activator of transcription 3	Mus musculus	68-73
22532166-5	2012	When exposed to the carcinogen nitrosamine, Stat3-transgenic mice developed invasive cancer directly from carcinoma in situ (CIS), bypassing the noninvasive papillary tumor stage.	Nitrosamines	31-42	signal transducer and activator of transcription 3	Mus musculus	44-49
22619361-8	2012	In addition, tyrosine and serine phosphorylation of total and mitochondrial signal transducer and activator of transcription 3 were enhanced in LSHKO compared with control mice.	Serine	26-32	signal transducer and activator of transcription 3	Mus musculus	76-126
21792892-0	2012	The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.	Cyclophosphamide	76-92	signal transducer and activator of transcription 3	Mus musculus	43-48
21792892-3	2012	We hypothesized that WP1066, a novel inhibitor of STAT3 signaling, would enhance the antitumor activity of cyclophosphamide (CTX) against melanoma, including disease within the CNS.	Cyclophosphamide	107-123	signal transducer and activator of transcription 3	Mus musculus	50-55
22623391-10	2012	BMSO administration increased phosphorylation of acetyl-CoA carboxylase, cAMP-activated protein kinase (PKA), and signal transducer and activator of transcription 3 in the white adipose tissue (WAT), suggesting that PKA and leptin signaling might be involved in the BMSO-mediated reduction in lipogenesis and increase in thermogenesis and lipolysis.	bmso	0-4	signal transducer and activator of transcription 3	Mus musculus	114-164
25436683-8	2012	We also investigated the effects of a membrane-permeable, peptide-based Stat3 inhibitor, recombinant Stat3-specific peptide aptamer (rS3-PA).	rs3-pa	133-139	signal transducer and activator of transcription 3	Mus musculus	101-106
25436683-10	2012	rS3-PA is able to penetrate the skin, enter cells, and reduce the level of activated Stat3.	rs3-pa	0-6	signal transducer and activator of transcription 3	Mus musculus	85-90
22824293-16	2012	In agreement with our in vitro results, tumors from PEITC-treated mice demonstrated reduced HER2, EGFR and STAT3 expression and increased apoptosis as revealed by cleavage of caspase 3 and PARP.	phenethyl isothiocyanate	52-57	signal transducer and activator of transcription 3	Mus musculus	107-112
22751139-4	2012	Here we report that under T(H)17-polarizing conditions, the transcription factors STAT3 and AhR upregulated the expression of Aiolos, a member of the Ikaros family of transcription factors.	Thorium	26-30	signal transducer and activator of transcription 3	Mus musculus	82-87
22659452-4	2012	Although Stat3(Delta/Delta) mice did not show any lung defects in terms of proliferation, apoptosis, or angiogenesis, they exhibited reduced urethane-induced tumorigenesis and increased antitumor inflammation and natural killer (NK) cell immunity.	Urethane	141-149	signal transducer and activator of transcription 3	Mus musculus	9-14
22328203-5	2012	Activation of STAT3 and MEK/ERK pathways were assessed after a single dose of isoproterenol by means of western blotting.	Isoproterenol	78-91	signal transducer and activator of transcription 3	Mus musculus	14-19
22328203-8	2012	Isoproterenol produced potent and rapid activation of both STAT3 and MEK/ERK pathways that returned to the levels of placebo treated controls after 24 hours.	Isoproterenol	0-13	signal transducer and activator of transcription 3	Mus musculus	59-64
22083490-8	2012	Taken together, the results suggest that pyranocoumarins may exert anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages through the inhibition of NF-kappaB and STAT3 activation.	Pyranocoumarins	41-56	signal transducer and activator of transcription 3	Mus musculus	173-178
25436683-0	2012	Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA.	rs3-pa	141-147	signal transducer and activator of transcription 3	Mus musculus	0-5
21340507-0	2012	Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.	FLLL 32	27-33	signal transducer and activator of transcription 3	Mus musculus	43-48
21340507-3	2012	LLL12 and FLLL32 inhibit STAT3 phosphorylation and STAT3 downstream targets.	FLLL 32	10-16	signal transducer and activator of transcription 3	Mus musculus	25-30
21340507-3	2012	LLL12 and FLLL32 inhibit STAT3 phosphorylation and STAT3 downstream targets.	FLLL 32	10-16	signal transducer and activator of transcription 3	Mus musculus	51-56
21340507-4	2012	LLL12 and FLLL32 also inhibit IL-6 induced STAT3 phosphorylation.	FLLL 32	10-16	signal transducer and activator of transcription 3	Mus musculus	43-48
21340507-8	2012	Blocking persistent STAT3 signaling by LLL12 and FLLL32 may be a novel therapeutic approach for osteosarcoma.	FLLL 32	49-55	signal transducer and activator of transcription 3	Mus musculus	20-25
22450950-5	2012	Pterostilbene-treated cells were analyzed for cytochrome C, Smac/DIABLO, manganese superoxide dismutase (MnSOD)/antioxidant activity, and STAT3 phosphorylation using ELISA.	pterostilbene	0-13	signal transducer and activator of transcription 3	Mus musculus	138-143
22450950-9	2012	In vitro, pterostilbene treatment altered levels of phosphorylated STAT3, MnSOD/antioxidant activity, cytochrome C, and Smac/DIABLO.	pterostilbene	10-23	signal transducer and activator of transcription 3	Mus musculus	67-72
22454431-4	2012	AG490 and Stattic, the specific inhibitors of JAK/STAT pathway, blocked the STAT1 and STAT3 tyrosine phosphorylation and decreased the gene expressions of proinflammatory cytokines induced by trichothecenes.	Tyrosine	92-100	signal transducer and activator of transcription 3	Mus musculus	86-91
22454431-4	2012	AG490 and Stattic, the specific inhibitors of JAK/STAT pathway, blocked the STAT1 and STAT3 tyrosine phosphorylation and decreased the gene expressions of proinflammatory cytokines induced by trichothecenes.	Trichothecenes	192-206	signal transducer and activator of transcription 3	Mus musculus	86-91
22454431-5	2012	Interestingly, the time when the mRNA levels of STAT1 and STAT3 were significantly upregulated was at 12 h, which was much later than the time when mitogen-activated protein kinase was activated, indicating that STATs might be the downstream targets of the trichothecenes.	Trichothecenes	257-271	signal transducer and activator of transcription 3	Mus musculus	58-63
22268811-7	2012	We found that PKCepsilon inhibition decreased p-ERK and p-Ser STAT3 levels without affecting p-Tyr STAT3.	Serine	58-61	signal transducer and activator of transcription 3	Mus musculus	62-67
21751211-8	2012	Angiotensin activation of Smad2 and Stat3 was also reduced in the AB3T aSMCs.	asmcs	71-76	signal transducer and activator of transcription 3	Mus musculus	36-41
22328572-5	2012	Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study.	cucurbitacin I	250-264	signal transducer and activator of transcription 3	Mus musculus	54-104
22328572-5	2012	Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study.	cucurbitacin I	250-264	signal transducer and activator of transcription 3	Mus musculus	106-111
22328572-5	2012	Microarray bioinformatics analysis suggested that the signal transducer and activator of transcription 3 (STAT3) pathway could be important in regulating the stemness signature in ATC-CD133+ cells; therefore, the effect of the potent STAT3 inhibitor cucurbitacin I in ATC-CD133+ cells was evaluated in this study.	cucurbitacin I	250-264	signal transducer and activator of transcription 3	Mus musculus	234-239
22328572-11	2012	Targeting STAT3 with cucurbitacin I in ATC may provide a new approach for therapeutic treatment in the future.	cucurbitacin I	21-35	signal transducer and activator of transcription 3	Mus musculus	10-15
21480396-0	2012	Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cepsilon with Stat3 involve integration with ERK1/2.	Tetradecanoylphorbol Acetate	26-62	signal transducer and activator of transcription 3	Mus musculus	131-136
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	signal transducer and activator of transcription 3	Mus musculus	49-54
21480396-8	2012	Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression.	Tetradecanoylphorbol Acetate	13-16	signal transducer and activator of transcription 3	Mus musculus	68-73
22210859-0	2012	Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity.	5-hydroxymethylcytosine	34-57	signal transducer and activator of transcription 3	Mus musculus	77-82
22413916-8	2012	Activation of the NF-kappaB pathway is mandatory for the synthesis and release of a pool of cytokines and chemokines, including IFN-beta, that induce tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)-1, STAT-2, and STAT-3, in an autocrine and paracrine manner, confirming that murine macrophages respond to Nef similarly to human ones.	Tyrosine	150-158	signal transducer and activator of transcription 3	Mus musculus	253-259
22405822-6	2012	Pretreatment with candesartan significantly inhibited Ang II- induced JAK/STAT3 phosphorylation.	candesartan	18-29	signal transducer and activator of transcription 3	Mus musculus	74-79
22116806-3	2012	The repression of microRNA clusters Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3) by retinoic acid in turn potentially upregulates the expression of Bim, Kit, Socs3, and Stat3.	Tretinoin	81-94	signal transducer and activator of transcription 3	Mus musculus	166-171
22169004-0	2012	A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury.	Nicotine	80-88	signal transducer and activator of transcription 3	Mus musculus	10-15
22169004-9	2012	Our results reveal a novel, chronic NIC-exposure-related and U-STAT3-dependent mechanism as mediator of a sustained transcription of genes that are linked to remodeling and inflammation in the kidney during injury.	Nicotine	36-39	signal transducer and activator of transcription 3	Mus musculus	63-68
22262759-6	2012	We show that carbon monoxide (CO) suppresses hepcidin expression elicited by IL-6- and ER-stress agents by inhibiting STAT-3 phosphorylation and CREBH maturation, respectively.	Carbon Monoxide	13-28	signal transducer and activator of transcription 3	Mus musculus	118-124
22262759-6	2012	We show that carbon monoxide (CO) suppresses hepcidin expression elicited by IL-6- and ER-stress agents by inhibiting STAT-3 phosphorylation and CREBH maturation, respectively.	Carbon Monoxide	30-32	signal transducer and activator of transcription 3	Mus musculus	118-124
22249380-0	2012	Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells.	cucurbitacin I	38-52	signal transducer and activator of transcription 3	Mus musculus	29-34
22249380-11	2012	Targeting STAT3 with cucurbitacin I may therefore represent a novel therapeutic approach for treating malignant brain tumors.	cucurbitacin I	21-35	signal transducer and activator of transcription 3	Mus musculus	10-15
22179221-6	2012	Moreover, GW501516 prevented IL-6-dependent induction of extracellular-related kinase 1/2 (ERK1/2), a serine-threonine protein kinase involved in serine STAT3 phosphorylation; the livers of Pparbeta/delta-null mice showed increased Tyr705- and Ser727-STAT3 as well as phospho-ERK1/2 levels.	GW 501516	10-18	signal transducer and activator of transcription 3	Mus musculus	153-158
22179221-6	2012	Moreover, GW501516 prevented IL-6-dependent induction of extracellular-related kinase 1/2 (ERK1/2), a serine-threonine protein kinase involved in serine STAT3 phosphorylation; the livers of Pparbeta/delta-null mice showed increased Tyr705- and Ser727-STAT3 as well as phospho-ERK1/2 levels.	GW 501516	10-18	signal transducer and activator of transcription 3	Mus musculus	251-256
22179221-6	2012	Moreover, GW501516 prevented IL-6-dependent induction of extracellular-related kinase 1/2 (ERK1/2), a serine-threonine protein kinase involved in serine STAT3 phosphorylation; the livers of Pparbeta/delta-null mice showed increased Tyr705- and Ser727-STAT3 as well as phospho-ERK1/2 levels.	Serine	102-108	signal transducer and activator of transcription 3	Mus musculus	153-158
22083490-0	2012	Pyranocoumarins isolated from Peucedanum praeruptorum Dunn suppress lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-kappaB and STAT3 activation.	Pyranocoumarins	0-15	signal transducer and activator of transcription 3	Mus musculus	175-180
22083490-7	2012	In addition, pyranocoumarins suppressed LPS-induced STAT3 tyrosine phosphorylation.	Pyranocoumarins	13-28	signal transducer and activator of transcription 3	Mus musculus	52-57
22083490-7	2012	In addition, pyranocoumarins suppressed LPS-induced STAT3 tyrosine phosphorylation.	Tyrosine	58-66	signal transducer and activator of transcription 3	Mus musculus	52-57
22349108-4	2012	METHODS: We investigated metformin-mediated SHP production improved insulin resistance through the regulation of an IL-6-dependent pathway (involving signal transducer and activator of transcription 3 [STAT3] and suppressor of cytokine signalling 3 [SOCS3]) in both Shp knockdown and Shp null mice.	Metformin	25-34	signal transducer and activator of transcription 3	Mus musculus	150-200
22349108-4	2012	METHODS: We investigated metformin-mediated SHP production improved insulin resistance through the regulation of an IL-6-dependent pathway (involving signal transducer and activator of transcription 3 [STAT3] and suppressor of cytokine signalling 3 [SOCS3]) in both Shp knockdown and Shp null mice.	Metformin	25-34	signal transducer and activator of transcription 3	Mus musculus	202-207
22349108-5	2012	RESULTS: IL-6-induced STAT3 transactivation and SOCS3 production were significantly repressed by metformin, adenoviral constitutively active AMPK (Ad-CA-AMPK), and adenoviral SHP (Ad-SHP), but not in Shp knockdown, or with the adenoviral dominant negative form of AMPK (Ad-DN-AMPK).	Metformin	97-106	signal transducer and activator of transcription 3	Mus musculus	22-27
22313262-9	2012	SOCS3 siRNA knockdown allowed STAT3 phosphorylation after rmIL-6 treatment.	rmil-6	58-64	signal transducer and activator of transcription 3	Mus musculus	30-35
22268811-9	2012	We suggest a novel alpha(1A)-AR mediated PKCepsilon/ERK pathway that regulates the phosphorylation status of STAT3 at Ser-727 while PKCdelta couples to SRC/JAK2 to affect Tyr-705 phosphorylation.	Serine	118-121	signal transducer and activator of transcription 3	Mus musculus	109-114
22268811-9	2012	We suggest a novel alpha(1A)-AR mediated PKCepsilon/ERK pathway that regulates the phosphorylation status of STAT3 at Ser-727 while PKCdelta couples to SRC/JAK2 to affect Tyr-705 phosphorylation.	Tyrosine	171-174	signal transducer and activator of transcription 3	Mus musculus	109-114
22268811-8	2012	In contrast, we found that PKCdelta inhibition affected p-SRC and p-JAK2 resulting in decreased p-Tyr and p-Ser STAT3 levels.	Serine	108-111	signal transducer and activator of transcription 3	Mus musculus	112-117
22252297-8	2012	CP-690,550 selectively inhibited IFN--induced STAT1, IL-4-induced STAT6 and IL-2-induced STAT5 at 3-30nM, while suppression of IL-6-induced STAT3 phosphorylation required a concentration greater than 100nM.	tofacitinib	0-6	signal transducer and activator of transcription 3	Mus musculus	140-145
23904970-5	2012	Moreover, STAT3 activation is typically equated with phosphorylation of a critical tyrosine residue.	Tyrosine	83-91	signal transducer and activator of transcription 3	Mus musculus	10-15
23904970-6	2012	Yet, STAT3 transcriptional behavior is subject to modulation by serine phosphorylation, acetylation, and redox status of the cell.	Serine	64-70	signal transducer and activator of transcription 3	Mus musculus	5-10
22120492-0	2012	Cyanidin-3-glucoside suppresses TNF-alpha-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling.	cyanidin-3-o-glucoside	0-20	signal transducer and activator of transcription 3	Mus musculus	169-174
22120492-9	2012	Administration of the ROS scavenger catalase (2,000 U/ml) remarkably inhibited TNF-alpha-induced cell proliferation and STAT3 activation.	ros	22-25	signal transducer and activator of transcription 3	Mus musculus	120-125
22155353-2	2012	Both Au and SiAu significantly increased the release of Ca, hydrogen peroxide, NO, IL-1alpha, IL-1beta, IL-6, IL-10, IP-10, MCP-1, MCP-3, TNF-alpha, RANTES, G-CSF, GM-CSF, LIF, MIP-2, VEGF, and PGE2 with enhancing expression of STAT1, STAT3, c-Fos, and COX-2 mRNA in RAW 264.7 cells.	Gold	5-7	signal transducer and activator of transcription 3	Mus musculus	235-240
22005518-5	2012	In addition, this quinone was found to exhibit anticancer activity through the modulation of multiple molecular targets, including p53, p73, PTEN, STAT3, PPAR-gamma, activation of caspases and generation of ROS.	quinone	18-25	signal transducer and activator of transcription 3	Mus musculus	147-152
21756853-1	2012	BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (STAT3), a key mediator of anti-inflammatory cytokine signaling, is essential for heme oxygenase-1 (HO-1)-induced cytoprotection.	Adenosine Monophosphate	12-15	signal transducer and activator of transcription 3	Mus musculus	23-73
21960021-6	2012	Octreotide prevented hypoxia-induced activation of STAT3 and HIF-1, and the downstream increase in VEGF expression, as evaluated in hypoxic explants treated with pharmacological inhibitors of STAT3 or HIF-1 and in normoxic explants in which pharmacological activators of STAT3 or HIF-1 were used to mimic a hypoxia-like response.	Octreotide	0-10	signal transducer and activator of transcription 3	Mus musculus	51-56
21960021-6	2012	Octreotide prevented hypoxia-induced activation of STAT3 and HIF-1, and the downstream increase in VEGF expression, as evaluated in hypoxic explants treated with pharmacological inhibitors of STAT3 or HIF-1 and in normoxic explants in which pharmacological activators of STAT3 or HIF-1 were used to mimic a hypoxia-like response.	Octreotide	0-10	signal transducer and activator of transcription 3	Mus musculus	192-197
21960021-6	2012	Octreotide prevented hypoxia-induced activation of STAT3 and HIF-1, and the downstream increase in VEGF expression, as evaluated in hypoxic explants treated with pharmacological inhibitors of STAT3 or HIF-1 and in normoxic explants in which pharmacological activators of STAT3 or HIF-1 were used to mimic a hypoxia-like response.	Octreotide	0-10	signal transducer and activator of transcription 3	Mus musculus	192-197
21960021-7	2012	The effect of octreotide on STAT3 activation is in part indirect, through the blockade of VEGFR-2 phosphorylation.	Octreotide	14-24	signal transducer and activator of transcription 3	Mus musculus	28-33
21960021-8	2012	The effect of octreotide on STAT3, HIF-1, VEGFR-2, and VEGF required Src homology region 2 domain-containing phosphatase 1 (SHP-1).	Octreotide	14-24	signal transducer and activator of transcription 3	Mus musculus	28-33
21960021-9	2012	In hypoxic extracts, octreotide induced SHP-1 phosphorylation and activation, and inhibiting SHP-1 abolished the octreotide effect on STAT3, HIF-1, VEGFR-2, and VEGF.	Octreotide	113-123	signal transducer and activator of transcription 3	Mus musculus	134-139
21756853-1	2012	BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (STAT3), a key mediator of anti-inflammatory cytokine signaling, is essential for heme oxygenase-1 (HO-1)-induced cytoprotection.	Adenosine Monophosphate	12-15	signal transducer and activator of transcription 3	Mus musculus	75-80
22206672-8	2012	Additionally, expression of SPARC decreased STAT3 phosphorylation at Tyr-705; constitutively active STAT3 expression reversed SPARC induced G2/M arrest.	Tyrosine	69-72	signal transducer and activator of transcription 3	Mus musculus	44-49
22280969-0	2012	Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).	3,3'-diindolylmethane	0-16	signal transducer and activator of transcription 3	Mus musculus	124-174
22280969-0	2012	Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).	3,3'-diindolylmethane	0-16	signal transducer and activator of transcription 3	Mus musculus	176-181
22280969-0	2012	Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).	Cisplatin	80-89	signal transducer and activator of transcription 3	Mus musculus	124-174
22280969-0	2012	Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3).	Cisplatin	80-89	signal transducer and activator of transcription 3	Mus musculus	176-181
22190485-5	2012	Small-molecule inhibitors of STAT3 phosphorylation and survivin restrict VZV replication in vitro, and VZV infection of skin xenografts in vivo is markedly impaired by the administration of the phospho-STAT3 inhibitor S3I-201.	NSC 74859	218-225	signal transducer and activator of transcription 3	Mus musculus	29-34
22190485-5	2012	Small-molecule inhibitors of STAT3 phosphorylation and survivin restrict VZV replication in vitro, and VZV infection of skin xenografts in vivo is markedly impaired by the administration of the phospho-STAT3 inhibitor S3I-201.	NSC 74859	218-225	signal transducer and activator of transcription 3	Mus musculus	202-207
22068968-7	2012	Further, increased apoptosis and a reduced proliferation were observed in the CCL(4)-treated mice after STI-571 treatment based on the immunohistochemical staining of Annexin V, phosphorylated STAT3, and PCNA.	Cefaclor	78-81	signal transducer and activator of transcription 3	Mus musculus	193-198
22068968-7	2012	Further, increased apoptosis and a reduced proliferation were observed in the CCL(4)-treated mice after STI-571 treatment based on the immunohistochemical staining of Annexin V, phosphorylated STAT3, and PCNA.	Imatinib Mesylate	104-111	signal transducer and activator of transcription 3	Mus musculus	193-198
22185775-5	2012	Thus, this paper explores the effect of butein (3,4,2",4"-tetrahydroxychalcone), a naturally occurring NFkappaB and STAT3 inhibitor, on the tumorigenic properties of MPM cells.	butein	40-46	signal transducer and activator of transcription 3	Mus musculus	116-121
22124464-11	2012	Trichostatin A, a histone deacetylase (HDAC) inhibitor, ameliorated ER stress-induced inhibition of STAT3 acetylation and phosphorylation.	trichostatin A	0-14	signal transducer and activator of transcription 3	Mus musculus	100-105
21898502-10	2012	In addition, sunitinib treatment of tumor-bearing mice was associated with suppression of STAT3 and a block in T-cell tolerance.	Sunitinib	13-22	signal transducer and activator of transcription 3	Mus musculus	90-95
21898502-11	2012	CONCLUSION: These findings indicate that sunitinib inhibits HCC tumor growth directly through the STAT3 pathway and prevents tumor antigen-specific CD8(+) T-cell tolerance, thus defining a synergistic chemoimmunotherapeutic approach for HCC.	Sunitinib	41-50	signal transducer and activator of transcription 3	Mus musculus	98-103
22762037-7	2012	Moreover, H(2)O(2) induced phosphorylation of ERK1/2 and STAT3 in 661W cells (P<0.05).	Hydrogen Peroxide	10-18	signal transducer and activator of transcription 3	Mus musculus	57-62
22762037-8	2012	After pretreatment with 50micromol/L PD98059 or S3I201 for 1 hour, H(2)O(2)-induced phosphorylation of ERK1/2 or STAT3 was suppressed separately (P<0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	37-44	signal transducer and activator of transcription 3	Mus musculus	113-118
22762037-8	2012	After pretreatment with 50micromol/L PD98059 or S3I201 for 1 hour, H(2)O(2)-induced phosphorylation of ERK1/2 or STAT3 was suppressed separately (P<0.05).	Hydrogen Peroxide	67-75	signal transducer and activator of transcription 3	Mus musculus	113-118
22762037-9	2012	Using PD98059 or S3I201 to inhibit ERK1/2 or STAT3 signal pathway, the cell viability of 661W cells decreased significantly (P<0.05).	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	6-13	signal transducer and activator of transcription 3	Mus musculus	45-50
22919282-0	2012	Constitutive over expression of IL-1beta, IL-6, NF-kappaB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice.	Urethane	114-122	signal transducer and activator of transcription 3	Mus musculus	63-68
22919282-0	2012	Constitutive over expression of IL-1beta, IL-6, NF-kappaB, and Stat3 is a potential cause of lung tumorgenesis in urethane (ethyl carbamate) induced Balb/c mice.	Urethane	124-139	signal transducer and activator of transcription 3	Mus musculus	63-68
24058750-5	2012	Here, we describe the functional characterization of the recombinant STAT3 inhibitor, rS3-PA.	rs3-pa	86-92	signal transducer and activator of transcription 3	Mus musculus	69-74
24058750-13	2012	Systemic administration of rS3-PA at doses of 7.5 mg/kg reduced P-STAT3 levels and significantly inhibited tumor growth up to 35% in a glioblastoma xenograft mouse model.	rs3-pa	27-33	signal transducer and activator of transcription 3	Mus musculus	66-71
22355274-3	2012	AZD1480 is a novel small molecule inhibitor of Jak1/2, which is a key mediator of STAT3 activation.	AZD 1480	0-7	signal transducer and activator of transcription 3	Mus musculus	82-87
21207415-8	2011	Furthermore, indirubin suppressed vascular endothelial growth factor receptor 2-mediated Janus kinase (JAK)/STAT3 signaling pathway but had little effects on the activity of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase in endothelial cell.	indirubin	13-22	signal transducer and activator of transcription 3	Mus musculus	108-113
23251458-7	2012	Moreover, PNU-282987 treatment enhanced phosphorylation of signal transducer and activator of transcription 3 (STAT3) in skeletal muscle, adipose tissue and liver in normal mice.	N-neopentyl-N-nitrosourea	10-13	signal transducer and activator of transcription 3	Mus musculus	59-109
23251458-7	2012	Moreover, PNU-282987 treatment enhanced phosphorylation of signal transducer and activator of transcription 3 (STAT3) in skeletal muscle, adipose tissue and liver in normal mice.	N-neopentyl-N-nitrosourea	10-13	signal transducer and activator of transcription 3	Mus musculus	111-116
23251458-9	2012	All together, these findings demonstrated that nicotine enhanced insulin sensitivity in animals with or without insulin resistance, at least in part via stimulating alpha7-nAChR-STAT3 pathway independent of inflammation.	Nicotine	47-55	signal transducer and activator of transcription 3	Mus musculus	178-183
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	signal transducer and activator of transcription 3	Mus musculus	144-149
22276206-11	2012	These data show that specifically POMC neurons of DIO mice are resistant to STAT3 activation by leptin, indicating that those cells might play a role in development of DIO.	3,3'-Dioctadecyloxacarbocyanine perchlorate	50-53	signal transducer and activator of transcription 3	Mus musculus	76-81
22864348-9	2012	A selective RARalpha/beta agonist, tamibarotene, also enhanced hepatic LEPR expression, STAT3 phosphorylation, and ameliorated insulin resistance in KK-Ay mice.	tamibarotene	35-47	signal transducer and activator of transcription 3	Mus musculus	88-93
22171059-6	2011	Furthermore, a significant decline of STAT3 tyrosine phosphorylation was observed by activation of PKC, while inhibition of PKC resulted in an increase of phosphorylated STAT3 along with a delayed cell cycle exit of progenitors with prolonged PCNA expression.	Tyrosine	44-52	signal transducer and activator of transcription 3	Mus musculus	38-43
22136659-7	2011	In vivo experiments were conducted with mice given diethylinitrosamine (DEN), which induces HCC was used to investigate the role of STAT3 expression in monocytes on tumor growth.	diethylinitrosamine	51-70	signal transducer and activator of transcription 3	Mus musculus	132-137
22136659-7	2011	In vivo experiments were conducted with mice given diethylinitrosamine (DEN), which induces HCC was used to investigate the role of STAT3 expression in monocytes on tumor growth.	Diethylnitrosamine	72-75	signal transducer and activator of transcription 3	Mus musculus	132-137
22136659-12	2011	The STAT3 inhibitor, NSC 74859, significantly suppressed tumor growth in vivo in mice with diethylinitrosamine (DEN)-induced HCC.	diethylinitrosamine	91-110	signal transducer and activator of transcription 3	Mus musculus	4-9
22136659-12	2011	The STAT3 inhibitor, NSC 74859, significantly suppressed tumor growth in vivo in mice with diethylinitrosamine (DEN)-induced HCC.	Diethylnitrosamine	112-115	signal transducer and activator of transcription 3	Mus musculus	4-9
21637293-8	2011	Long-term bromodeoxyuridine labelling directly demonstrated that functional STAT3 is required for +4 to +6 region label-retaining small-intestine stem cell survival.	Bromodeoxyuridine	10-27	signal transducer and activator of transcription 3	Mus musculus	76-81
21952584-6	2011	Relative to overweight control, DIO increased whereas 30% CR reduced activation of Akt, mTORC1, STAT3, and NFkappaB (p65) in ventral prostate.	Chromium	58-60	signal transducer and activator of transcription 3	Mus musculus	96-101
23251458-0	2012	Chronic exposure to nicotine enhances insulin sensitivity through alpha7 nicotinic acetylcholine receptor-STAT3 pathway.	Nicotine	20-28	signal transducer and activator of transcription 3	Mus musculus	106-111
23166651-8	2012	Both iNOS transcription and NO secretion were inhibited in the presence of the specific p-STAT3 inhibitor JSI-124.	cucurbitacin I	106-113	signal transducer and activator of transcription 3	Mus musculus	90-95
23166651-10	2012	STAT3 activation and the consequent release of NO are responsible for the inhibitory functions of DCapos.	dcapos	98-104	signal transducer and activator of transcription 3	Mus musculus	0-5
23094067-14	2012	NAC also inhibited the overexpression of p-STAT3 and VEGF in CNV and in RPE cells.	Acetylcysteine	0-3	signal transducer and activator of transcription 3	Mus musculus	43-48
22937084-11	2012	CONCLUSIONS/SIGNIFICANCE: Honokiol increases expression and activity of SPH-1 that further deactivates STAT3 pathway.	honokiol	26-34	signal transducer and activator of transcription 3	Mus musculus	103-108
22905257-8	2012	We show that NCP in the presence of diamide enhanced STAT3 glutathionylation and dimerization in adult mouse cardiac myocytes and altered STAT3 under non-reducing conditions.	Diamide	36-43	signal transducer and activator of transcription 3	Mus musculus	53-58
22905257-8	2012	We show that NCP in the presence of diamide enhanced STAT3 glutathionylation and dimerization in adult mouse cardiac myocytes and altered STAT3 under non-reducing conditions.	Diamide	36-43	signal transducer and activator of transcription 3	Mus musculus	138-143
22479586-0	2012	Heme mediated STAT3 activation in severe malaria.	Heme	0-4	signal transducer and activator of transcription 3	Mus musculus	14-19
22479586-7	2012	RESULTS: The results demonstrate that (1) STAT3 is activated by P. berghei ANKA (PBA) infection in vivo and Heme in vitro.	Heme	108-112	signal transducer and activator of transcription 3	Mus musculus	42-47
22479586-8	2012	(2) Heme up-regulates HO-1 and CXCL10 production through STAT3 pathway, and regulates CXCL10 at the transcriptional level in vitro.	Heme	4-8	signal transducer and activator of transcription 3	Mus musculus	57-62
22511936-10	2012	CONCLUSION: Jam2 is highly expressed in the luminal epithelium of receptive uterus and up-regulated by progesterone and LIF via tyrosine phosphorylation of Stat3.	Progesterone	103-115	signal transducer and activator of transcription 3	Mus musculus	156-161
22511936-10	2012	CONCLUSION: Jam2 is highly expressed in the luminal epithelium of receptive uterus and up-regulated by progesterone and LIF via tyrosine phosphorylation of Stat3.	Tyrosine	128-136	signal transducer and activator of transcription 3	Mus musculus	156-161
22027691-9	2011	In vivo, AZD1480 inhibits the growth of subcutaneous tumors and increases survival of mice bearing intracranial GBM tumors by inhibiting STAT-3 activity, indicating that pharmacologic inhibition of the JAK/STAT-3 pathway by AZD1480 should be considered for study in the treatment of patients with GBM tumors.	AZD 1480	9-16	signal transducer and activator of transcription 3	Mus musculus	137-143
22027691-9	2011	In vivo, AZD1480 inhibits the growth of subcutaneous tumors and increases survival of mice bearing intracranial GBM tumors by inhibiting STAT-3 activity, indicating that pharmacologic inhibition of the JAK/STAT-3 pathway by AZD1480 should be considered for study in the treatment of patients with GBM tumors.	AZD 1480	9-16	signal transducer and activator of transcription 3	Mus musculus	206-212
21480310-4	2011	To develop a potent strategy to increase therapeutic efficacy and reduce drug resistance in prostate cancer therapy, we combined two anti-cancer agents: T40214 (a p-Stat3 inhibitor) and JG244 (a HIF-1alpha inhibitor) together to treat nude mice bearing human prostate tumor (DU145) and immunocompetent mice (C57BL/6) bearing murine prostate tumor (TRAMP-C2).	t40214	153-159	signal transducer and activator of transcription 3	Mus musculus	165-170
21856923-6	2011	The results were further confirmed by in vivo experiments involving intraperitoneal injection of the STAT3 inhibitor WP1066 significantly inhibiting phenylephrine-infusion-induced heart hypertrophy in male C57BL/6 mice.	WP1066	117-123	signal transducer and activator of transcription 3	Mus musculus	101-106
21809363-6	2011	Our study showed that Stat3 tyrosine 705 phosphorylation and several Stat3-regulated antiapoptotic genes were down-regulated in miR-637 mimics-transfected and Lv-miR637-infected HCC cells.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	22-27
21868636-6	2011	STAT3 phosphorylated at its tyrosine-705 (p-STAT3) in the ligated gland increased immediately after ligation, and it was localized in the nuclei of all duct cells.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	0-5
21868636-6	2011	STAT3 phosphorylated at its tyrosine-705 (p-STAT3) in the ligated gland increased immediately after ligation, and it was localized in the nuclei of all duct cells.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	44-49
21859833-2	2011	Extensive studies indicate that capsaicin is a cancer-suppressing agent via blocking the activities of several signal transduction pathways including nuclear factor-kappaB, activator protein-1 and signal transducer and activator of transcription 3.	Capsaicin	32-41	signal transducer and activator of transcription 3	Mus musculus	197-247
21843953-6	2011	Moreover, IL-22 treatment significantly enhanced activation of STAT3 and up-regulated the expression of Bcl-xL, heme oxygenase-1 (HO-1) and redox factor-1 (Ref-1) in the liver injury induced by GalN/LPS.	Galactosamine	194-198	signal transducer and activator of transcription 3	Mus musculus	63-68
21821671-7	2011	Moreover, we demonstrated that a specific STAT3 inhibitor, S3I-201, reduces cyst formation and growth in a neonatal PKD mouse model.	s3i-	59-63	signal transducer and activator of transcription 3	Mus musculus	42-47
21354226-0	2011	Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma.	Sorafenib	91-100	signal transducer and activator of transcription 3	Mus musculus	0-50
21354226-1	2011	BACKGROUND & AIMS: Recently, we reported that sorafenib sensitizes hepatocellular carcinoma (HCC) cells to TRAIL through the inhibition of signal transducer and activator of transcription 3 (STAT3).	Sorafenib	50-59	signal transducer and activator of transcription 3	Mus musculus	143-193
21354226-1	2011	BACKGROUND & AIMS: Recently, we reported that sorafenib sensitizes hepatocellular carcinoma (HCC) cells to TRAIL through the inhibition of signal transducer and activator of transcription 3 (STAT3).	Sorafenib	50-59	signal transducer and activator of transcription 3	Mus musculus	195-200
21856923-6	2011	The results were further confirmed by in vivo experiments involving intraperitoneal injection of the STAT3 inhibitor WP1066 significantly inhibiting phenylephrine-infusion-induced heart hypertrophy in male C57BL/6 mice.	Phenylephrine	149-162	signal transducer and activator of transcription 3	Mus musculus	101-106
22074622-7	2011	RESULTS: In addition to the well-characterized tyrosine 705 phosphorylation of STAT3, LIF removal results in the rapid phosphorylation of multiple other proteins known to regulate the mESC self-renewal on both tyrosine, serine, and threonine residues.	Tyrosine	47-55	signal transducer and activator of transcription 3	Mus musculus	79-84
21842893-0	2011	In vitro cellular uptake and dimerization of signal transducer and activator of transcription-3 (STAT3) identify the photosensitizing and imaging-potential of isomeric photosensitizers derived from chlorophyll-a and bacteriochlorophyll-a.	chlorophyll a	198-211	signal transducer and activator of transcription 3	Mus musculus	45-95
21982455-0	2011	Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells.	tyrosine-fructose	23-40	signal transducer and activator of transcription 3	Mus musculus	189-194
21982455-0	2011	Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-beta generation and inflammatory reactions via inhibition of NF-kappaB and STAT3 activation in cultured astrocytes and microglial BV-2 cells.	2,4-bis(p-hydroxyphenyl)-2-butenal	68-102	signal transducer and activator of transcription 3	Mus musculus	189-194
21982455-10	2011	Moreover, studies using signal transducer and activator of transcription 3 (STAT3) siRNA and a pharmacological inhibitor showed that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits LPS-induced activation of STAT3.	2,4-bis(p-hydroxyphenyl)-2-butenal	133-167	signal transducer and activator of transcription 3	Mus musculus	24-74
21982455-10	2011	Moreover, studies using signal transducer and activator of transcription 3 (STAT3) siRNA and a pharmacological inhibitor showed that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits LPS-induced activation of STAT3.	2,4-bis(p-hydroxyphenyl)-2-butenal	133-167	signal transducer and activator of transcription 3	Mus musculus	76-81
21982455-10	2011	Moreover, studies using signal transducer and activator of transcription 3 (STAT3) siRNA and a pharmacological inhibitor showed that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits LPS-induced activation of STAT3.	2,4-bis(p-hydroxyphenyl)-2-butenal	133-167	signal transducer and activator of transcription 3	Mus musculus	203-208
21982455-11	2011	CONCLUSIONS: These results indicate that 2,4-bis(p-hydroxyphenyl)-2-butenal inhibits neuroinflammatory reactions and amyloidogenesis through inhibition of NF-kappaB and STAT3 activation, and suggest that 2,4-bis(p-hydroxyphenyl)-2-butenal may be useful for the treatment of neuroinflammatory diseases like Alzheimer"s disease.	2,4-bis(p-hydroxyphenyl)-2-butenal	41-75	signal transducer and activator of transcription 3	Mus musculus	169-174
21842893-0	2011	In vitro cellular uptake and dimerization of signal transducer and activator of transcription-3 (STAT3) identify the photosensitizing and imaging-potential of isomeric photosensitizers derived from chlorophyll-a and bacteriochlorophyll-a.	chlorophyll a	198-211	signal transducer and activator of transcription 3	Mus musculus	97-102
21741923-9	2011	Induction of PTK6 increased apoptosis, proliferation, and STAT3 activation in Ptk6+/+ mice injected with azoxymethane.	Azoxymethane	105-117	signal transducer and activator of transcription 3	Mus musculus	58-63
21354136-10	2011	Trans-Chalcone also blocked ischemia-induced VEGF and ICAM-1 expression and this effect correlated with inhibition of activated STAT3 and NF-kappaB.	Chalcone	0-14	signal transducer and activator of transcription 3	Mus musculus	128-133
21741923-13	2011	CONCLUSIONS: PTK6 promotes STAT3 activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 activity in mouse colon tumors and in the HCT116 and young adult mouse colon cell lines.	Azoxymethane	95-107	signal transducer and activator of transcription 3	Mus musculus	27-32
21633967-7	2011	CONCLUSION: Notch signal protects hepatocytes from I/R injury by Hes5-dependent activation of STAT3, which activates the expression of MnSOD, leading to the scavenging of ROS.	Reactive Oxygen Species	171-174	signal transducer and activator of transcription 3	Mus musculus	94-99
21621648-8	2011	We demonstrated that IL-17 was involved in the inflammatory response to hepatic I/R injury, and that triptolide inhibited IL-17 generation and suppressed neutrophil migration after liver I/R injury through downregulation of signal transducer and activator of transcription 3 (STAT3) transcription.	triptolide	101-111	signal transducer and activator of transcription 3	Mus musculus	224-274
21621648-8	2011	We demonstrated that IL-17 was involved in the inflammatory response to hepatic I/R injury, and that triptolide inhibited IL-17 generation and suppressed neutrophil migration after liver I/R injury through downregulation of signal transducer and activator of transcription 3 (STAT3) transcription.	triptolide	101-111	signal transducer and activator of transcription 3	Mus musculus	276-281
21810913-3	2011	In turn, this correlates with STAT3 phosphorylation on tyrosine 705 residue (pSTAT3) and HIF-1alpha accumulation.	Tyrosine	55-63	signal transducer and activator of transcription 3	Mus musculus	30-35
21633967-0	2011	Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling.	Reactive Oxygen Species	100-123	signal transducer and activator of transcription 3	Mus musculus	148-153
21725996-11	2011	Resistance to steatosis in these mice is attributable to elevation of inflammation-associated hepatic IL-6/STAT3 activation that subsequently down-regulates lipogenic genes but up-regulates fatty acid oxidation-associated genes in the liver.	Fatty Acids	190-200	signal transducer and activator of transcription 3	Mus musculus	107-112
21555004-0	2011	Osteoblast/osteocyte-specific inactivation of Stat3 decreases load-driven bone formation and accumulates reactive oxygen species.	Reactive Oxygen Species	105-128	signal transducer and activator of transcription 3	Mus musculus	46-51
21555004-6	2011	Furthermore, inactivation of Stat3 suppressed load-driven mitochondrial activity, which led to an elevated level of reactive oxygen species (ROS) in cultured primary osteoblasts.	Reactive Oxygen Species	116-139	signal transducer and activator of transcription 3	Mus musculus	29-34
21555004-6	2011	Furthermore, inactivation of Stat3 suppressed load-driven mitochondrial activity, which led to an elevated level of reactive oxygen species (ROS) in cultured primary osteoblasts.	Reactive Oxygen Species	141-144	signal transducer and activator of transcription 3	Mus musculus	29-34
21519350-4	2011	Further study revealed that TCV significantly decreased the production of both interleukin (IL)-17 and IL-23 in intrapancreatic infiltrating lymphocytes (IPL) through marked inhibition of mRNA level of retinoic acid-related orphan receptor gammat (RORgammat) and signal transducer and activator of transcription 3 (Stat3) phosphorylation.	Trichloroethylene	28-31	signal transducer and activator of transcription 3	Mus musculus	263-313
21519350-4	2011	Further study revealed that TCV significantly decreased the production of both interleukin (IL)-17 and IL-23 in intrapancreatic infiltrating lymphocytes (IPL) through marked inhibition of mRNA level of retinoic acid-related orphan receptor gammat (RORgammat) and signal transducer and activator of transcription 3 (Stat3) phosphorylation.	Trichloroethylene	28-31	signal transducer and activator of transcription 3	Mus musculus	315-320
21733838-7	2011	Rac1 activity and phosphorylated STAT3 level were significantly attenuated in the 8-OHdG-treated group.	8-ohdg	82-88	signal transducer and activator of transcription 3	Mus musculus	33-38
21784871-4	2011	To this end, we developed a novel ligand-targeted nanoparticle (NP) encapsulating a CDDO-Im payload capable of specific delivery to the TME, which showed an effective therapeutic inhibition of STAT-3 activation in primary tumors.	2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid	84-88	signal transducer and activator of transcription 3	Mus musculus	193-199
21715323-0	2011	Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.	Reactive Oxygen Species	178-201	signal transducer and activator of transcription 3	Mus musculus	23-73
21715323-0	2011	Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.	Reactive Oxygen Species	178-201	signal transducer and activator of transcription 3	Mus musculus	75-80
21715323-1	2011	Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species.	Reactive Oxygen Species	106-129	signal transducer and activator of transcription 3	Mus musculus	18-23
21801866-11	2011	Furthermore, Stat3 is required for DALDA-induced colonocyte migration.	tyrosyl-arginyl-phenylalanyl-lysinamide	35-40	signal transducer and activator of transcription 3	Mus musculus	13-18
21396905-6	2011	Withaferin A significantly inhibited LPS-induced STAT1 and STAT3 phosphorylation in a dose-dependent manner.	withaferin A	0-12	signal transducer and activator of transcription 3	Mus musculus	59-64
21354226-2	2011	Here, we report that sorafenib inhibits HCC via a kinase-independent mechanism: SHP-1 dependent STAT3 inactivation.	Sorafenib	21-30	signal transducer and activator of transcription 3	Mus musculus	96-101
21354226-7	2011	SC-1 down-regulated phosphorylation of phospho-STAT3 (p-STAT3) at tyrosine 705 in all tested HCC cells.	Tyrosine	66-74	signal transducer and activator of transcription 3	Mus musculus	47-52
21354226-7	2011	SC-1 down-regulated phosphorylation of phospho-STAT3 (p-STAT3) at tyrosine 705 in all tested HCC cells.	Tyrosine	66-74	signal transducer and activator of transcription 3	Mus musculus	56-61
21354226-9	2011	Luciferase reporter assay confirmed the inhibition of transcriptional activity of STAT3 in both sorafenib-treated and SC-1-treated cells.	Sorafenib	96-105	signal transducer and activator of transcription 3	Mus musculus	82-87
21354226-14	2011	CONCLUSIONS: STAT3 is a major kinase-independent target of sorafenib in HCC.	Sorafenib	59-68	signal transducer and activator of transcription 3	Mus musculus	13-18
21873987-8	2011	Finally, central administration of ROS alone increased c-fos and phosphorylated signal transducer and activator of transcription 3 (pStat3) expression in POMC neurons and reduced feeding of DIO mice.	Reactive Oxygen Species	35-38	signal transducer and activator of transcription 3	Mus musculus	80-130
21601613-7	2011	In spleens from the allergic mouse model, the expressions of STAT3, STAT4, STAT5a, STAT6, GATA3 and Foxp3 mRNAs were significantly enhanced following exposure to 50ppm toluene for 6 weeks, but the expression of T-bet mRNA was not increased.	Toluene	168-175	signal transducer and activator of transcription 3	Mus musculus	61-66
21684247-4	2011	Hepatocyte-specific STAT3 knockout mice were resistant to liver tumorigenesis induced by a single DEN injection, whose tumorigenesis was associated with minimal chronic liver inflammation, injury, and fibrosis.	Diethylnitrosamine	98-101	signal transducer and activator of transcription 3	Mus musculus	20-25
21684247-6	2011	Despite the oncogenic function of STAT3 in DEN-induced liver tumor, hepatocyte-specific STAT3 knockout mice were more susceptible to liver tumorigenesis after 16 weeks of CCl(4) injection, which was associated with higher levels of liver injury, inflammation, fibrosis, and oxidative DNA damage compared with wild-type mice.	Cefaclor	171-174	signal transducer and activator of transcription 3	Mus musculus	88-93
21597011-10	2011	Finally, we found that nicotine reduced levels of pSTAT3 (phosphorylated signal transducer and activator of transcription 3) protein expression within the myocardium.	Nicotine	23-31	signal transducer and activator of transcription 3	Mus musculus	73-123
21396905-8	2011	Taken together, these results suggest that withaferin A inhibits LPS-induced PGE(2) production and COX-2 expression, at least in part, by blocking STAT1 and STAT3 activation.	withaferin A	43-55	signal transducer and activator of transcription 3	Mus musculus	157-162
21806874-4	2011	Pretreatment of PD98059 or U0126 inhibited TNF-induced IL-6 release and ERK phosphorylation in P815 cells (P<0.05), whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release, with little effect on phosphorylation of p38 and STAT3 respectively.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	16-23	signal transducer and activator of transcription 3	Mus musculus	238-243
21806874-4	2011	Pretreatment of PD98059 or U0126 inhibited TNF-induced IL-6 release and ERK phosphorylation in P815 cells (P<0.05), whereas pretreatment of SB203580 or AG490 hardly affect IL-6 release, with little effect on phosphorylation of p38 and STAT3 respectively.	U 0126	27-32	signal transducer and activator of transcription 3	Mus musculus	238-243
21747053-5	2011	Accordingly, nuclear STAT3 tyrosine phosphorylation was decreased in knockout mice.	Tyrosine	27-35	signal transducer and activator of transcription 3	Mus musculus	21-26
21586612-4	2011	Large-scale screening of cancer cell lines with a JAK2 inhibitor that blocks STAT3 function revealed a more than 30-fold range in sensitivity in PDAC, and showed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor, an upstream signaling component.	pdac	145-149	signal transducer and activator of transcription 3	Mus musculus	77-82
21586612-4	2011	Large-scale screening of cancer cell lines with a JAK2 inhibitor that blocks STAT3 function revealed a more than 30-fold range in sensitivity in PDAC, and showed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor, an upstream signaling component.	Tyrosine	212-220	signal transducer and activator of transcription 3	Mus musculus	77-82
21586612-4	2011	Large-scale screening of cancer cell lines with a JAK2 inhibitor that blocks STAT3 function revealed a more than 30-fold range in sensitivity in PDAC, and showed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor, an upstream signaling component.	Tyrosine	212-220	signal transducer and activator of transcription 3	Mus musculus	236-241
21617181-6	2011	This effect was associated with the capacity of the drug to prevent IL-6-induced STAT3 phosphorylation on Tyr(705) and Ser(727) residues in vitro and in vivo.	Tyrosine	106-109	signal transducer and activator of transcription 3	Mus musculus	81-86
21593197-7	2011	Both CR and rapamycin decreased phosphorylation of mTOR, p70/S6K, and S6 ribosomal protein, but only CR decreased phosphorylation of Akt, GSK-3beta, extracellular signal regulated kinase/mitogen-activated protein kinase, and STAT3(TYR705).	Chromium	5-7	signal transducer and activator of transcription 3	Mus musculus	225-230
21593197-7	2011	Both CR and rapamycin decreased phosphorylation of mTOR, p70/S6K, and S6 ribosomal protein, but only CR decreased phosphorylation of Akt, GSK-3beta, extracellular signal regulated kinase/mitogen-activated protein kinase, and STAT3(TYR705).	Chromium	101-103	signal transducer and activator of transcription 3	Mus musculus	225-230
21617181-6	2011	This effect was associated with the capacity of the drug to prevent IL-6-induced STAT3 phosphorylation on Tyr(705) and Ser(727) residues in vitro and in vivo.	Serine	119-122	signal transducer and activator of transcription 3	Mus musculus	81-86
21617181-7	2011	Moreover, GW501516 prevented IL-6-dependent induction of extracellular signal-related kinase (ERK)1/2, a serine-threonine-protein kinase involved in serine STAT3 phosphorylation.	GW 501516	10-18	signal transducer and activator of transcription 3	Mus musculus	156-161
21617181-7	2011	Moreover, GW501516 prevented IL-6-dependent induction of extracellular signal-related kinase (ERK)1/2, a serine-threonine-protein kinase involved in serine STAT3 phosphorylation.	Serine	105-111	signal transducer and activator of transcription 3	Mus musculus	156-161
21471252-7	2011	Administration of STAT3 inhibitor S31-201 (IC50 of 38.0 +- 7.2 muM for IL-6-induced STAT3 phosphorylation), but not PBS control, to p53(null)CD45.1 mice suppressed Th17 effectors and alleviated autoimmune pathology.	NSC 74859	34-41	signal transducer and activator of transcription 3	Mus musculus	18-23
21471252-7	2011	Administration of STAT3 inhibitor S31-201 (IC50 of 38.0 +- 7.2 muM for IL-6-induced STAT3 phosphorylation), but not PBS control, to p53(null)CD45.1 mice suppressed Th17 effectors and alleviated autoimmune pathology.	NSC 74859	34-41	signal transducer and activator of transcription 3	Mus musculus	84-89
20711698-5	2011	T3 decreased tyrosine phosphorylation of JAK1, JAK2 and STAT3, and subsequently inhibited STAT3-DNA binding activity.	Tyrosine	13-21	signal transducer and activator of transcription 3	Mus musculus	56-61
21536676-1	2011	To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the role of epidermal growth factor receptor (EGFR).	15-hydroxy-5,8,11,13-eicosatetraenoic acid	38-72	signal transducer and activator of transcription 3	Mus musculus	96-146
21536676-1	2011	To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the role of epidermal growth factor receptor (EGFR).	15-hydroxy-5,8,11,13-eicosatetraenoic acid	38-72	signal transducer and activator of transcription 3	Mus musculus	148-153
21536676-1	2011	To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the role of epidermal growth factor receptor (EGFR).	15-hydroxy-5,8,11,13-eicosatetraenoic acid	74-84	signal transducer and activator of transcription 3	Mus musculus	96-146
21536676-1	2011	To understand the mechanisms by which 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) activates signal transducer and activator of transcription 3 (STAT3), we studied the role of epidermal growth factor receptor (EGFR).	15-hydroxy-5,8,11,13-eicosatetraenoic acid	74-84	signal transducer and activator of transcription 3	Mus musculus	148-153
21536676-3	2011	Interference with EGFR activation blocked 15(S)-HETE-induced Src and STAT3 tyrosine phosphorylation, monocyte chemoattractant protein-1 (MCP-1) expression and VSMC migration.	Tyrosine	75-83	signal transducer and activator of transcription 3	Mus musculus	69-74
21536676-6	2011	15(S)-HETE induced the production of H(2)O(2) via an NADPH oxidase-dependent manner and its scavengers, N-acetyl cysteine (NAC) and catalase suppressed 15(S)-HETE-stimulated EGFR, Src, Jak2, and STAT3 phosphorylation and MCP-1 expression.	Hydroxyeicosatetraenoic Acids	3-10	signal transducer and activator of transcription 3	Mus musculus	195-200
21465537-8	2011	Finally, mouse embryonic fibroblasts (MEFs) lacking STAT3 reduced the inhibitory effect of TSA on cell proliferation, add-back of wild type STAT3 to STAT3(-/-) MEFs restored the effect of TSA.	trichostatin A	91-94	signal transducer and activator of transcription 3	Mus musculus	52-57
21536676-6	2011	15(S)-HETE induced the production of H(2)O(2) via an NADPH oxidase-dependent manner and its scavengers, N-acetyl cysteine (NAC) and catalase suppressed 15(S)-HETE-stimulated EGFR, Src, Jak2, and STAT3 phosphorylation and MCP-1 expression.	Hydrogen Peroxide	37-45	signal transducer and activator of transcription 3	Mus musculus	195-200
21465537-8	2011	Finally, mouse embryonic fibroblasts (MEFs) lacking STAT3 reduced the inhibitory effect of TSA on cell proliferation, add-back of wild type STAT3 to STAT3(-/-) MEFs restored the effect of TSA.	trichostatin A	91-94	signal transducer and activator of transcription 3	Mus musculus	140-145
21465537-8	2011	Finally, mouse embryonic fibroblasts (MEFs) lacking STAT3 reduced the inhibitory effect of TSA on cell proliferation, add-back of wild type STAT3 to STAT3(-/-) MEFs restored the effect of TSA.	trichostatin A	91-94	signal transducer and activator of transcription 3	Mus musculus	140-145
21465537-8	2011	Finally, mouse embryonic fibroblasts (MEFs) lacking STAT3 reduced the inhibitory effect of TSA on cell proliferation, add-back of wild type STAT3 to STAT3(-/-) MEFs restored the effect of TSA.	trichostatin A	188-191	signal transducer and activator of transcription 3	Mus musculus	140-145
21465537-8	2011	Finally, mouse embryonic fibroblasts (MEFs) lacking STAT3 reduced the inhibitory effect of TSA on cell proliferation, add-back of wild type STAT3 to STAT3(-/-) MEFs restored the effect of TSA.	trichostatin A	188-191	signal transducer and activator of transcription 3	Mus musculus	140-145
21536676-6	2011	15(S)-HETE induced the production of H(2)O(2) via an NADPH oxidase-dependent manner and its scavengers, N-acetyl cysteine (NAC) and catalase suppressed 15(S)-HETE-stimulated EGFR, Src, Jak2, and STAT3 phosphorylation and MCP-1 expression.	Acetylcysteine	104-121	signal transducer and activator of transcription 3	Mus musculus	195-200
21467030-4	2011	Here, we show that STAT3 mRNA and protein levels and the accumulation of serine-phosphorylated STAT3 in mitochondria were increased significantly in Sirt1-KO cells as compared with wild-type MEFs.	Serine	73-79	signal transducer and activator of transcription 3	Mus musculus	95-100
21574661-0	2011	Inhibition of ulcerative colitis in mice after oral administration of a polyphenol-enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells.	Polyphenols	72-82	signal transducer and activator of transcription 3	Mus musculus	149-154
21617181-9	2011	Several steps in STAT3 activation require its association with heat shock protein 90 (Hsp90), which was prevented by GW501516 as revealed in immunoprecipitation studies.	GW 501516	117-125	signal transducer and activator of transcription 3	Mus musculus	17-22
21467030-6	2011	Two independent approaches, including ectopic expression of SIRT1 and siRNA-mediated knockdown of STAT3, led to reduction in intracellular ATP levels and increased lactate production in Sirt1-KO cells that were approaching those of wild-type controls.	Adenosine Triphosphate	139-142	signal transducer and activator of transcription 3	Mus musculus	98-103
21467030-6	2011	Two independent approaches, including ectopic expression of SIRT1 and siRNA-mediated knockdown of STAT3, led to reduction in intracellular ATP levels and increased lactate production in Sirt1-KO cells that were approaching those of wild-type controls.	Lactic Acid	164-171	signal transducer and activator of transcription 3	Mus musculus	98-103
21497192-0	2011	Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-kappaB pathway.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	104-109
21511023-0	2011	Anti-dermatitis effects of oak wood vinegar on the DNCB-induced contact hypersensitivity via STAT3 suppression.	Dinitrochlorobenzene	51-55	signal transducer and activator of transcription 3	Mus musculus	93-98
21268125-11	2011	These data suggest that COX-2-generated PGE2 regulates survivin expression in mouse skin, in part, via an EP2-mediated EGFR/STAT3 pathway.	Dinoprostone	40-44	signal transducer and activator of transcription 3	Mus musculus	124-129
21518725-0	2011	B7-H3 silencing increases paclitaxel sensitivity by abrogating Jak2/Stat3 phosphorylation.	Paclitaxel	26-36	signal transducer and activator of transcription 3	Mus musculus	68-73
21518725-5	2011	Next, we investigated the mechanisms behind B7-H3-mediated paclitaxel resistance and found that the level of Stat3 Tyr705 phosphorylation was decreased in B7-H3 knockdown cells along with the expression of its direct downstream targets Mcl-1 and survivin.	Paclitaxel	59-69	signal transducer and activator of transcription 3	Mus musculus	109-114
21518725-10	2011	Taken together, our data show that in breast cancer cells, B7-H3 induces paclitaxel resistance, at least partially by interfering with Jak2/Stat3 pathway.	Paclitaxel	73-83	signal transducer and activator of transcription 3	Mus musculus	140-145
21376468-3	2011	At the cellular level, the effect of leptin on spinal NMDA-induced currents was mediated through the leptin receptor and the JAK2/STAT3 (but not PI3K or MAPK) pathway, as the leptin effect was abolished in leptin receptor-deficient (db/db) mice and inhibited by a JAK/STAT inhibitor.	N-Methylaspartate	54-58	signal transducer and activator of transcription 3	Mus musculus	130-135
21633673-3	2011	In our previous studies, we demonstrated the efficacy of stearic acid-modified polyethylenimine (PEI-StA) in promoting small interfering RNA (siRNA) silencing of STAT3 in B16.F10 melanoma in vitro and in vivo.	stearic acid	57-69	signal transducer and activator of transcription 3	Mus musculus	162-167
21633673-3	2011	In our previous studies, we demonstrated the efficacy of stearic acid-modified polyethylenimine (PEI-StA) in promoting small interfering RNA (siRNA) silencing of STAT3 in B16.F10 melanoma in vitro and in vivo.	Polyethyleneimine	79-95	signal transducer and activator of transcription 3	Mus musculus	162-167
21633673-3	2011	In our previous studies, we demonstrated the efficacy of stearic acid-modified polyethylenimine (PEI-StA) in promoting small interfering RNA (siRNA) silencing of STAT3 in B16.F10 melanoma in vitro and in vivo.	pei-sta	97-104	signal transducer and activator of transcription 3	Mus musculus	162-167
21497192-8	2011	Western blot analysis showed that andrographolide significantly inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and the protein expression of CCAAT/enhancer-binding protein delta (C/EBPdelta).	andrographolide	34-49	signal transducer and activator of transcription 3	Mus musculus	97-147
21497192-8	2011	Western blot analysis showed that andrographolide significantly inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and the protein expression of CCAAT/enhancer-binding protein delta (C/EBPdelta).	andrographolide	34-49	signal transducer and activator of transcription 3	Mus musculus	149-154
21497192-10	2011	Our results demonstrate that andrographolide downregulates inflammatory iNOS and COX-2 gene expression by inhibiting the activation of NF-kappaB and STAT3 by interfering with the expression of SOCS1 and SOCS3 signalling.	andrographolide	29-44	signal transducer and activator of transcription 3	Mus musculus	149-154
21486047-1	2011	Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on growth factor and cytokine receptors via its SH2 domain.	Phosphotyrosine	128-143	signal transducer and activator of transcription 3	Mus musculus	0-50
21486047-1	2011	Signal transducer and activator of transcription 3 (Stat3), a target for anticancer drug design, is activated by recruitment to phosphotyrosine residues on growth factor and cytokine receptors via its SH2 domain.	Phosphotyrosine	128-143	signal transducer and activator of transcription 3	Mus musculus	52-57
21486047-4	2011	Bis-pivaloyloxymethyl prodrugs containing beta-methylcinnamide, dipeptide scaffolds Haic and Nle-cis-3,4-methanoproline, and glutamine surrogates were highly potent, completely inhibiting phosphorylation of Stat3 Tyr705 at 0.5-1 muM in a variety of cancer cell lines.	2,2-dimethanidylpropanoyl(methylidene)oxidanium	4-21	signal transducer and activator of transcription 3	Mus musculus	207-212
21486047-4	2011	Bis-pivaloyloxymethyl prodrugs containing beta-methylcinnamide, dipeptide scaffolds Haic and Nle-cis-3,4-methanoproline, and glutamine surrogates were highly potent, completely inhibiting phosphorylation of Stat3 Tyr705 at 0.5-1 muM in a variety of cancer cell lines.	beta-methylcinnamide	42-62	signal transducer and activator of transcription 3	Mus musculus	207-212
21486047-4	2011	Bis-pivaloyloxymethyl prodrugs containing beta-methylcinnamide, dipeptide scaffolds Haic and Nle-cis-3,4-methanoproline, and glutamine surrogates were highly potent, completely inhibiting phosphorylation of Stat3 Tyr705 at 0.5-1 muM in a variety of cancer cell lines.	Dipeptides	64-73	signal transducer and activator of transcription 3	Mus musculus	207-212
21486047-4	2011	Bis-pivaloyloxymethyl prodrugs containing beta-methylcinnamide, dipeptide scaffolds Haic and Nle-cis-3,4-methanoproline, and glutamine surrogates were highly potent, completely inhibiting phosphorylation of Stat3 Tyr705 at 0.5-1 muM in a variety of cancer cell lines.	Glutamine	125-134	signal transducer and activator of transcription 3	Mus musculus	207-212
21226522-0	2011	Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development.	Cysteine	14-22	signal transducer and activator of transcription 3	Mus musculus	30-35
21345977-9	2011	Importantly, Pkd1-deletion mice that were treated with curcumin and killed at an early stage of PKD displayed improved renal histology and reduced STAT3 activation, proliferation index, cystic index, and kidney weight/body weight ratios.	Curcumin	55-63	signal transducer and activator of transcription 3	Mus musculus	147-152
21297658-0	2011	Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo.	Durapatite	39-53	signal transducer and activator of transcription 3	Mus musculus	14-19
21297658-8	2011	The results showed that hydroxyapatite-delivered si-Stat3 significantly suppressed tumour growth up to 74% (P < 0.01).	Durapatite	24-38	signal transducer and activator of transcription 3	Mus musculus	52-57
21297658-3	2011	The effects on the growth of mouse prostate cancer cells of si-Stat3 delivered by hydroxyapatite were determined in this study.	Durapatite	82-96	signal transducer and activator of transcription 3	Mus musculus	63-68
21360571-5	2011	Additionally, sorafenib inhibited TGF-beta1-induced signal transducer and activator of transcription 3 phosphorylation.	Sorafenib	14-23	signal transducer and activator of transcription 3	Mus musculus	52-102
21357267-0	2011	Alcohol suppresses the granulopoietic response to pulmonary Streptococcus pneumoniae infection with enhancement of STAT3 signaling.	Alcohols	0-7	signal transducer and activator of transcription 3	Mus musculus	115-120
21357267-8	2011	Alcohol treatment significantly enhanced STAT3 phosphorylation in bone marrow cells of animals challenged with S. pneumoniae.	Alcohols	0-7	signal transducer and activator of transcription 3	Mus musculus	41-46
21357267-9	2011	In vitro experiments showed that G-CSF-induced activation of STAT3-p27(Kip1) pathway in murine myeloid progenitor cell line 32D-G-CSFR cells was markedly enhanced by alcohol exposure.	Alcohols	166-173	signal transducer and activator of transcription 3	Mus musculus	61-66
21357267-12	2011	These data suggest that alcohol enhances G-CSF-associated STAT3-p27(Kip1) signaling, which impairs granulopoietic progenitor cell proliferation by inducing cell cycling arrest and facilitating their terminal differentiation during the granulopoietic response to pulmonary infection.	Alcohols	24-31	signal transducer and activator of transcription 3	Mus musculus	58-63
21268125-10	2011	Furthermore, butaprost in the absence of UVB exposure time-dependently increased p-EGFR, p-STAT3, and survivin levels in naive mouse skin, whereas the EP4 agonist, PGE1 alcohol, did not significantly increase p-STAT3 or survivin levels.	butaprost	13-22	signal transducer and activator of transcription 3	Mus musculus	91-96
21268125-10	2011	Furthermore, butaprost in the absence of UVB exposure time-dependently increased p-EGFR, p-STAT3, and survivin levels in naive mouse skin, whereas the EP4 agonist, PGE1 alcohol, did not significantly increase p-STAT3 or survivin levels.	butaprost	13-22	signal transducer and activator of transcription 3	Mus musculus	211-216
21342247-5	2011	Furthermore, we investigated whether both melatonin and resveratrol protect via the activation of the newly discovered survivor activating factor enhancement (SAFE) prosurvival signaling pathway that involves the activation of tumor necrosis factor alpha (TNFalpha) and the signal transducer and activator of transcription 3 (STAT3).	Resveratrol	56-67	signal transducer and activator of transcription 3	Mus musculus	274-324
21342247-5	2011	Furthermore, we investigated whether both melatonin and resveratrol protect via the activation of the newly discovered survivor activating factor enhancement (SAFE) prosurvival signaling pathway that involves the activation of tumor necrosis factor alpha (TNFalpha) and the signal transducer and activator of transcription 3 (STAT3).	Resveratrol	56-67	signal transducer and activator of transcription 3	Mus musculus	326-331
21342247-10	2011	Furthermore, perfusion with either melatonin or resveratrol increased STAT3 phosphorylation prior to ischemia by 79% and 50%, respectively (P < 0.001 versus control).	Melatonin	35-44	signal transducer and activator of transcription 3	Mus musculus	70-75
21342247-10	2011	Furthermore, perfusion with either melatonin or resveratrol increased STAT3 phosphorylation prior to ischemia by 79% and 50%, respectively (P < 0.001 versus control).	Resveratrol	48-59	signal transducer and activator of transcription 3	Mus musculus	70-75
21174489-9	2011	Upregulated STAT3 and downregulated TIMP-1 were significantly different in MSC + BiAb + MB compared with MSC alone or MSC + BiAb.	Antibodies, Bispecific	81-85	signal transducer and activator of transcription 3	Mus musculus	12-17
21223971-4	2011	We created an inducible, cardiomyocyte-restricted STAT3 deficient mouse (MCM TG:STAT3(flox/flox)) by interbreeding STAT3(flox/flox) mice and tamoxifen-inducible MCM TG mice.	Thioguanine	77-79	signal transducer and activator of transcription 3	Mus musculus	50-55
21223971-4	2011	We created an inducible, cardiomyocyte-restricted STAT3 deficient mouse (MCM TG:STAT3(flox/flox)) by interbreeding STAT3(flox/flox) mice and tamoxifen-inducible MCM TG mice.	flox	86-90	signal transducer and activator of transcription 3	Mus musculus	50-55
21297658-5	2011	CaCl2-modified hydroxyapatite carrying si-Stat3 plasmids were injected into tumours, and tumour growth and histology were determined.	Calcium Chloride	0-5	signal transducer and activator of transcription 3	Mus musculus	42-47
21223971-4	2011	We created an inducible, cardiomyocyte-restricted STAT3 deficient mouse (MCM TG:STAT3(flox/flox)) by interbreeding STAT3(flox/flox) mice and tamoxifen-inducible MCM TG mice.	Thioguanine	165-167	signal transducer and activator of transcription 3	Mus musculus	50-55
21297658-5	2011	CaCl2-modified hydroxyapatite carrying si-Stat3 plasmids were injected into tumours, and tumour growth and histology were determined.	Durapatite	15-29	signal transducer and activator of transcription 3	Mus musculus	42-47
21223971-5	2011	Treatment of MCM TG:STAT3(flox/flox) mice with tamoxifen resulted in deletion of STAT3 specifically in cardiac myocytes, concomitant with abrogation of ischemic PC-induced Tyr-705 and Ser-727 phosphorylation of STAT3 and increased STAT3 DNA-binding activity.	Tamoxifen	47-56	signal transducer and activator of transcription 3	Mus musculus	20-25
21223971-5	2011	Treatment of MCM TG:STAT3(flox/flox) mice with tamoxifen resulted in deletion of STAT3 specifically in cardiac myocytes, concomitant with abrogation of ischemic PC-induced Tyr-705 and Ser-727 phosphorylation of STAT3 and increased STAT3 DNA-binding activity.	Tamoxifen	47-56	signal transducer and activator of transcription 3	Mus musculus	81-86
21216604-6	2011	Moreover, lead STAT3 inhibitor 14aa induced a time-dependent inhibition of constitutive STAT3 activation in v-Src transformed mouse fibroblasts (NIH3T3/v-Src), with 80% suppression of constitutively-active STAT3 at 6h following treatment of NIH3T3/v-Src.	14aa	31-35	signal transducer and activator of transcription 3	Mus musculus	15-20
21223971-5	2011	Treatment of MCM TG:STAT3(flox/flox) mice with tamoxifen resulted in deletion of STAT3 specifically in cardiac myocytes, concomitant with abrogation of ischemic PC-induced Tyr-705 and Ser-727 phosphorylation of STAT3 and increased STAT3 DNA-binding activity.	Tamoxifen	47-56	signal transducer and activator of transcription 3	Mus musculus	81-86
21223971-5	2011	Treatment of MCM TG:STAT3(flox/flox) mice with tamoxifen resulted in deletion of STAT3 specifically in cardiac myocytes, concomitant with abrogation of ischemic PC-induced Tyr-705 and Ser-727 phosphorylation of STAT3 and increased STAT3 DNA-binding activity.	Tamoxifen	47-56	signal transducer and activator of transcription 3	Mus musculus	81-86
21305673-0	2011	LacdiNAc (GalNAcbeta1-4GlcNAc) contributes to self-renewal of mouse embryonic stem cells by regulating leukemia inhibitory factor/STAT3 signaling.	N-acetylgalactosaminyl-1-4-N-acetylglucosamine	0-8	signal transducer and activator of transcription 3	Mus musculus	130-135
21305673-0	2011	LacdiNAc (GalNAcbeta1-4GlcNAc) contributes to self-renewal of mouse embryonic stem cells by regulating leukemia inhibitory factor/STAT3 signaling.	N-acetylgalactosaminyl-1-4-N-acetylglucosamine	10-29	signal transducer and activator of transcription 3	Mus musculus	130-135
21305673-4	2011	Here, we show that the cell surface glycan LacdiNAc (GalNAcbeta1-4GlcNAc) is required for LIF/STAT3 signaling.	glycan lacdinac	36-51	signal transducer and activator of transcription 3	Mus musculus	94-99
21305673-4	2011	Here, we show that the cell surface glycan LacdiNAc (GalNAcbeta1-4GlcNAc) is required for LIF/STAT3 signaling.	N-acetylgalactosaminyl-1-4-N-acetylglucosamine	53-72	signal transducer and activator of transcription 3	Mus musculus	94-99
21216604-6	2011	Moreover, lead STAT3 inhibitor 14aa induced a time-dependent inhibition of constitutive STAT3 activation in v-Src transformed mouse fibroblasts (NIH3T3/v-Src), with 80% suppression of constitutively-active STAT3 at 6h following treatment of NIH3T3/v-Src.	14aa	31-35	signal transducer and activator of transcription 3	Mus musculus	88-93
21216604-6	2011	Moreover, lead STAT3 inhibitor 14aa induced a time-dependent inhibition of constitutive STAT3 activation in v-Src transformed mouse fibroblasts (NIH3T3/v-Src), with 80% suppression of constitutively-active STAT3 at 6h following treatment of NIH3T3/v-Src.	14aa	31-35	signal transducer and activator of transcription 3	Mus musculus	88-93
21216930-8	2011	Combined EGFR inhibition with erlotinib and siltuximab resulted in dual inhibition of both tyrosine and serine STAT3 phosphorylation, more pronounced inhibition of STAT3 transcriptional activity, and translated into combined effects on lung cancer growth in a mouse model.	Erlotinib Hydrochloride	30-39	signal transducer and activator of transcription 3	Mus musculus	111-116
21372039-6	2011	EGCG inhibited the phosphorylation of the IGF-1R, ERK (extracellular signal-regulated kinase), Akt, GSK-3beta (glycogen synthase kinase-3beta), Stat3, and JNK (c-Jun NH(2)-terminal kinase) proteins in the livers of experimental mice.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	144-149
21164517-8	2011	Importantly, AZD1480 induces cell death of Kms.11 cells grown in the presence of HS-5 bone marrow (BM)-derived stromal cells and inhibits tumor growth in a Kms.11 xenograft mouse model, accompanied with inhibition of phospho-FGFR3, phospho-JAK2, phospho-STAT3 and Cyclin D2 levels.	AZD 1480	13-20	signal transducer and activator of transcription 3	Mus musculus	254-259
21216930-8	2011	Combined EGFR inhibition with erlotinib and siltuximab resulted in dual inhibition of both tyrosine and serine STAT3 phosphorylation, more pronounced inhibition of STAT3 transcriptional activity, and translated into combined effects on lung cancer growth in a mouse model.	Erlotinib Hydrochloride	30-39	signal transducer and activator of transcription 3	Mus musculus	164-169
21163936-0	2011	Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma.	Erlotinib Hydrochloride	40-49	signal transducer and activator of transcription 3	Mus musculus	19-24
21163936-5	2011	The drugs under investigation included erlotinib, a small molecule inhibitor of the EGFR, and guggulipid, the extract of an Ayurvedic medicinal plant, which contains guggulsterone, a compound known to inhibit STAT3.	guggulu extract	94-104	signal transducer and activator of transcription 3	Mus musculus	209-214
21163936-5	2011	The drugs under investigation included erlotinib, a small molecule inhibitor of the EGFR, and guggulipid, the extract of an Ayurvedic medicinal plant, which contains guggulsterone, a compound known to inhibit STAT3.	pregna-4,17-diene-3,16-dione	166-179	signal transducer and activator of transcription 3	Mus musculus	209-214
21738612-10	2011	Nrdp1 may be a key mediator in the development of cardiac dysfunction after DOX treatment and associated with inhibition of Akt, ERK1/2 and STAT3.	Doxorubicin	76-79	signal transducer and activator of transcription 3	Mus musculus	140-145
21148797-0	2011	Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia.	Leukotrienes	55-66	signal transducer and activator of transcription 3	Mus musculus	30-35
20811392-3	2011	In this study, we examined whether STA-21, a small Stat3 inhibitor, could be useful in ameliorating the skin lesions not only in the model mouse but also in human psoriasis.	STA-21	35-41	signal transducer and activator of transcription 3	Mus musculus	51-56
21237434-0	2011	Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis.	Diphosphonates	0-15	signal transducer and activator of transcription 3	Mus musculus	43-93
21237434-8	2011	CONCLUSIONS: These data demonstrate that, in addition to their effects on macrophage viability, BPs can decrease STAT3 and SOCS3 expression, which are important modulators of immune responses and bone homeostasis.	Diphosphonates	96-99	signal transducer and activator of transcription 3	Mus musculus	113-118
21532164-6	2011	However, S/B remedy induced STAT3 and subsequently suppressor of cytokine signaling (SOCS3) activation in mouse liver and increased serum IL-6 level in a dose-dependent manner, which could be partially blocked by pretreatment with gadolinium chloride.	gadolinium chloride	231-250	signal transducer and activator of transcription 3	Mus musculus	28-33
20886344-0	2011	Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway.	Aspirin	0-7	signal transducer and activator of transcription 3	Mus musculus	113-118
20886344-1	2011	BACKGROUND AND AIMS: Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC.	Aspirin	21-28	signal transducer and activator of transcription 3	Mus musculus	147-197
20886344-1	2011	BACKGROUND AND AIMS: Aspirin is associated with a reduced risk of colorectal cancer (CRC), and it showed inhibited effects on interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway which is thought to play an important role in intestinal inflammation and the tumorigenesis of CRC.	Aspirin	21-28	signal transducer and activator of transcription 3	Mus musculus	199-204
20886344-6	2011	The expression level of IL-6, which is an upstream molecule of STAT3 and capable of activating STAT3, was reduced in aspirin-treated mice.	Aspirin	117-124	signal transducer and activator of transcription 3	Mus musculus	63-68
20886344-6	2011	The expression level of IL-6, which is an upstream molecule of STAT3 and capable of activating STAT3, was reduced in aspirin-treated mice.	Aspirin	117-124	signal transducer and activator of transcription 3	Mus musculus	95-100
20886344-7	2011	Furthermore, the phosphorylated form of STAT3 and the levels of STAT3"s target gene products such as Bcl-xl and Bcl-2, which are essential for cell growth and survival, were also decreased in aspirin-treated mice.	Aspirin	192-199	signal transducer and activator of transcription 3	Mus musculus	40-45
20886344-7	2011	Furthermore, the phosphorylated form of STAT3 and the levels of STAT3"s target gene products such as Bcl-xl and Bcl-2, which are essential for cell growth and survival, were also decreased in aspirin-treated mice.	Aspirin	192-199	signal transducer and activator of transcription 3	Mus musculus	64-69
20886344-8	2011	CONCLUSIONS: Our data suggested that the protective mechanisms of aspirin in CRC may be associated with its effects on induction of CRC cell apoptosis and suppression of IL-6-STAT3 signaling pathway, which implied that aspirin has a potential therapeutic activity in CRC.	Aspirin	66-73	signal transducer and activator of transcription 3	Mus musculus	175-180
20886344-8	2011	CONCLUSIONS: Our data suggested that the protective mechanisms of aspirin in CRC may be associated with its effects on induction of CRC cell apoptosis and suppression of IL-6-STAT3 signaling pathway, which implied that aspirin has a potential therapeutic activity in CRC.	Aspirin	219-226	signal transducer and activator of transcription 3	Mus musculus	175-180
22110749-0	2011	Capric acid inhibits NO production and STAT3 activation during LPS-induced osteoclastogenesis.	decanoic acid	0-11	signal transducer and activator of transcription 3	Mus musculus	39-44
22110749-9	2011	However, capric acid inhibited LPS-induced phosphorylation of Ser(727) in STAT3.	decanoic acid	9-20	signal transducer and activator of transcription 3	Mus musculus	74-79
22110749-9	2011	However, capric acid inhibited LPS-induced phosphorylation of Ser(727) in STAT3.	Serine	62-65	signal transducer and activator of transcription 3	Mus musculus	74-79
22110749-11	2011	In conclusion, we demonstrated that capric acid inhibited LPS-induced osteoclastogenesis by suppressing NO production via the STAT3 pathway.	decanoic acid	36-47	signal transducer and activator of transcription 3	Mus musculus	126-131
21931823-8	2011	Suppressing STAT3 activation with the JAK/STAT antagonist AG490 restored the antimetastatic effect of the TLR4/9 agonist complex.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	58-63	signal transducer and activator of transcription 3	Mus musculus	12-17
20959465-8	2010	Butaprost also induced the activation of Akt, ERK1/2, and STAT3, and both beta-arrestin1 deficiency and EGFR inhibition (AG1478 or gefitinib) decreased their activation.	butaprost	0-9	signal transducer and activator of transcription 3	Mus musculus	58-63
21056997-9	2010	Leptin receptor-free tumor cells display reduced STAT3 tyrosine phosphorylation on residue Y705 but have increased serine phosphorylation on residue S727, consistent with preserved mitochondrial function in the absence of the leptin receptor.	Tyrosine	55-63	signal transducer and activator of transcription 3	Mus musculus	49-54
20490462-8	2010	In parallel, heightened expression of Th2 cytokines (IL-4, IL-5, IL-6) and signal molecules (Stat3 and Socs3) were observed in the airways of silica-exposed mice.	Silicon Dioxide	142-148	signal transducer and activator of transcription 3	Mus musculus	93-98
20847306-0	2010	Indirubin-3"-monoxime blocks vascular smooth muscle cell proliferation by inhibition of signal transducer and activator of transcription 3 signaling and reduces neointima formation in vivo.	indirubin-3'-monoxime	0-21	signal transducer and activator of transcription 3	Mus musculus	88-138
20847306-6	2010	The specific STAT3 inhibitor Stattic led to decreased VSMC proliferation, and transient expression of a constitutively active form of STAT3 overcame the I3MO-induced cell cycle arrest in mouse embryonic fibroblasts.	vsmc	54-58	signal transducer and activator of transcription 3	Mus musculus	13-18
20881248-5	2010	Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling.	Dexamethasone	51-64	signal transducer and activator of transcription 3	Mus musculus	92-97
21138870-0	2010	Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway.	Curcumin	8-16	signal transducer and activator of transcription 3	Mus musculus	97-102
21138870-6	2010	RESULTS: In vitro, curcumin inhibited JAK1,2/STAT3 tyrosine-phosphorylation in a dose-dependent fashion in murine glioma cell lines.	Curcumin	19-27	signal transducer and activator of transcription 3	Mus musculus	45-50
21138870-6	2010	RESULTS: In vitro, curcumin inhibited JAK1,2/STAT3 tyrosine-phosphorylation in a dose-dependent fashion in murine glioma cell lines.	Tyrosine	51-59	signal transducer and activator of transcription 3	Mus musculus	45-50
21138870-7	2010	Real-time RT-PCR revealed that curcumin downregulated transcription of the STAT3 target genes c-Myc, MMP-9, Snail, and Twist, and of the proliferation marker Ki67.	Curcumin	31-39	signal transducer and activator of transcription 3	Mus musculus	75-80
20881248-5	2010	Our results show that the synthetic glucocorticoid dexamethasone (DEX) modulates STAT5A and STAT3 signaling and inhibits apoptosis induction in postlactating mouse mammary glands, only when administered within the first 48 h upon cessation of suckling.	Dexamethasone	66-69	signal transducer and activator of transcription 3	Mus musculus	92-97
20881248-8	2010	Moreover, DEX administration delayed STAT3 activation and translocation into epithelial cells nuclei.	Dexamethasone	10-13	signal transducer and activator of transcription 3	Mus musculus	37-42
20881248-9	2010	In particular, DEX treatment impaired the increment in gene expression of signal transducer subunit gp130, normally up-regulated from lactation to involution and responsible for STAT3 activation.	Dexamethasone	15-18	signal transducer and activator of transcription 3	Mus musculus	178-183
20959490-4	2010	Stat3 tyrosine 705 phosphorylation and expression of several Stat3-regulated antiapoptotic genes were higher in Gprc5a(-/-) than in Gprc5a(+/+) cells.	Tyrosine	6-14	signal transducer and activator of transcription 3	Mus musculus	0-5
20667973-6	2010	Phosphorylation of the signal transducer and activator of transcription 3 (STAT3) was also markedly accelerated in the crypts of DSS-treated BLT2(-/-) mice.	dss	129-132	signal transducer and activator of transcription 3	Mus musculus	23-73
20667973-6	2010	Phosphorylation of the signal transducer and activator of transcription 3 (STAT3) was also markedly accelerated in the crypts of DSS-treated BLT2(-/-) mice.	dss	129-132	signal transducer and activator of transcription 3	Mus musculus	75-80
20980634-6	2010	Notably, within minutes after exposure to galectin-3, JAK2 and STAT1, STAT3, and STAT5 showed considerable enhancement of tyrosine phosphorylation; thereafter, downstream events of STAT signaling were also significantly enhanced.	Tyrosine	122-130	signal transducer and activator of transcription 3	Mus musculus	70-75
21073728-9	2010	STAT3 activation followed paw swelling and cytokine levels in both models and correlates of disease could be ablated upon treatment with dexamethasone.	Dexamethasone	137-150	signal transducer and activator of transcription 3	Mus musculus	0-5
20938668-0	2010	Ethanolamine is a novel STAT-3 dependent cardioprotective agent.	Ethanolamine	0-12	signal transducer and activator of transcription 3	Mus musculus	24-30
20938668-5	2010	Therefore, we investigated whether ethanolamine protects the heart via activation of STAT-3.	Ethanolamine	35-47	signal transducer and activator of transcription 3	Mus musculus	85-91
20938668-10	2010	Pre-treatment with ethanolamine increased nuclear phosphorylated STAT-3 [control 0.75 +- 0.08 vs. Etn 1.50 +- 0.09 arbitrary units; P < 0.05].	Ethanolamine	19-31	signal transducer and activator of transcription 3	Mus musculus	65-71
20938668-11	2010	Our findings suggest a novel cardioprotective role for ethanolamine against I/R injury via activation of STAT-3.	Ethanolamine	55-67	signal transducer and activator of transcription 3	Mus musculus	105-111
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	Adenosine Diphosphate	0-3	signal transducer and activator of transcription 3	Mus musculus	107-112
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	Adenosine Diphosphate	0-3	signal transducer and activator of transcription 3	Mus musculus	114-122
20960209-6	2010	ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide).	stattic	234-270	signal transducer and activator of transcription 3	Mus musculus	107-112
20960209-8	2010	STAT3 co-immunoprecipitated with cyclophilin D, the target of the cardioprotective agent and MPTP inhibitor cyclosporine A (CsA).	Cyclosporine	108-122	signal transducer and activator of transcription 3	Mus musculus	0-5
20960209-8	2010	STAT3 co-immunoprecipitated with cyclophilin D, the target of the cardioprotective agent and MPTP inhibitor cyclosporine A (CsA).	Cyclosporine	124-127	signal transducer and activator of transcription 3	Mus musculus	0-5
20960209-9	2010	However, CsA reduced infarct size to a similar extent in wildtype and STAT3-KO mice in vivo.	Cyclosporine	9-12	signal transducer and activator of transcription 3	Mus musculus	70-78
21895408-2	2011	In this study, short hairpin RNA targeting STAT3 was cloned into pGenesil-2 plasmid vector and the effects of STAT3 silencing in 4T1 breast cancer cells were analyzed both in vitro and in vivo.	pgenesil	65-73	signal transducer and activator of transcription 3	Mus musculus	43-48
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	signal transducer and activator of transcription 3	Mus musculus	89-139
20959520-8	2010	In cell lines developed from the KPC mice, the triterpenoids directly interact with both signal transducer and activator of transcription 3 and IkappaB kinase (IKK) to decrease constitutive interleukin-6 secretion, inhibit constitutive signal transducer and activator of transcription 3 phosphorylation, and block the degradation of IkappaBalpha when challenged with tumor necrosis factor alpha.	triterpenoids	47-60	signal transducer and activator of transcription 3	Mus musculus	236-286
20844196-6	2010	Cisplatin treatment caused increases in renal IL-10R1 expression and STAT3 phosphorylation.	Cisplatin	0-9	signal transducer and activator of transcription 3	Mus musculus	69-74
20884624-0	2010	Sorafenib overcomes TRAIL resistance of hepatocellular carcinoma cells through the inhibition of STAT3.	Sorafenib	0-9	signal transducer and activator of transcription 3	Mus musculus	97-102
20884624-8	2010	Our data showed that sorafenib downregulated phospho-STAT3 (pSTAT3) and subsequently reduced the expression levels of STAT3-related proteins (Mcl-1, survivin, and cyclin D1) in a dose- and time-dependent manner in TRAIL-treated HCC cells.	Sorafenib	21-30	signal transducer and activator of transcription 3	Mus musculus	53-58
20884624-8	2010	Our data showed that sorafenib downregulated phospho-STAT3 (pSTAT3) and subsequently reduced the expression levels of STAT3-related proteins (Mcl-1, survivin, and cyclin D1) in a dose- and time-dependent manner in TRAIL-treated HCC cells.	Sorafenib	21-30	signal transducer and activator of transcription 3	Mus musculus	61-66
20884624-9	2010	Knockdown of STAT3 by RNA interference overcame apoptotic resistance to TRAIL in HCC cells, and ectopic expression of STAT3 in HCC cells abolished the TRAIL-sensitizing effect of sorafenib.	Sorafenib	179-188	signal transducer and activator of transcription 3	Mus musculus	13-18
20884624-9	2010	Knockdown of STAT3 by RNA interference overcame apoptotic resistance to TRAIL in HCC cells, and ectopic expression of STAT3 in HCC cells abolished the TRAIL-sensitizing effect of sorafenib.	Sorafenib	179-188	signal transducer and activator of transcription 3	Mus musculus	118-123
20884624-13	2010	CONCLUSIONS: Sorafenib sensitizes resistant HCC cells to TRAIL-induced apoptosis at clinical achievable concentrations, and this effect is mediated via the inhibition of STAT3.	Sorafenib	13-22	signal transducer and activator of transcription 3	Mus musculus	170-175
20798359-4	2010	OBJECTIVE: To identify the potential role of STAT3 arginine methylation by PRMT2 in the regulation of leptin signaling and energy homeostasis.	Arginine	51-59	signal transducer and activator of transcription 3	Mus musculus	45-50
20798359-9	2010	Absence of PRMT2 results in decreased methylation and prolonged tyrosine phosphorylation of hypothalamic STAT3, which was associated with increased expression of hypothalamic proopiomelanocortin following leptin stimulation.	Tyrosine	64-72	signal transducer and activator of transcription 3	Mus musculus	105-110
20798359-10	2010	CONCLUSIONS: These data elucidate a molecular pathway that directly links arginine methylation of STAT3 by PRMT2 to the regulation of leptin signaling, suggesting a potential role for PRMT2 antagonism in the treatment of obesity and obesity-related syndromes.	Arginine	74-82	signal transducer and activator of transcription 3	Mus musculus	98-103
20804176-3	2010	We have shown that STAT3 knockdown in B16 murine melanoma by siRNA polyplexes of polyethylenimine (PEI) or its stearic acid derivative (PEI-StA) induces B16 cell death in vitro and in vivo.	Polyethyleneimine	81-97	signal transducer and activator of transcription 3	Mus musculus	19-24
20804176-3	2010	We have shown that STAT3 knockdown in B16 murine melanoma by siRNA polyplexes of polyethylenimine (PEI) or its stearic acid derivative (PEI-StA) induces B16 cell death in vitro and in vivo.	Polyethyleneimine	99-102	signal transducer and activator of transcription 3	Mus musculus	19-24
20804176-3	2010	We have shown that STAT3 knockdown in B16 murine melanoma by siRNA polyplexes of polyethylenimine (PEI) or its stearic acid derivative (PEI-StA) induces B16 cell death in vitro and in vivo.	stearic acid	111-123	signal transducer and activator of transcription 3	Mus musculus	19-24
20804176-4	2010	Here, we investigated the physical encapsulation of siRNA/PEI and PEI-StA polyplexes in poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) for STAT3 knockdown in DCs.	Polylactic Acid-Polyglycolic Acid Copolymer	88-120	signal transducer and activator of transcription 3	Mus musculus	153-158
20818497-3	2010	Further studies identified that UA treatment suppressed diabetes-induced activations of STAT-3, ERK1/2 and JNK pathways, but not the diabetes-induced activation of the p38 pathway.	ursolic acid	32-34	signal transducer and activator of transcription 3	Mus musculus	88-94
20682646-3	2010	To investigate the antitumor effects of inhibiting the STAT3-mediated signaling cascade in the cancer microenvironment, using a molecular-targeting approach, we focused on the gene associated with retinoid-IFN-induced mortality 19 (GRIM-19).	Retinoids	197-205	signal transducer and activator of transcription 3	Mus musculus	55-60
20562529-6	2010	STAT3 (Tyr 705) activation and cyclin-D1 protein/mRNA levels were significantly decreased up on HBO exposure.	Tyrosine	7-10	signal transducer and activator of transcription 3	Mus musculus	0-5
20393690-7	2010	JAK2 inhibition specifically prevents LPS-induced STAT3 tyrosine phosphorylation without affecting serine phosphorylation in macrophages.	Tyrosine	56-64	signal transducer and activator of transcription 3	Mus musculus	50-55
20944006-5	2010	RA promoted bone marrow-derived DC production of bioactive TGF-beta by inhibiting suppressor of cytokine signaling 3 expression and thereby enhancing STAT3 activation.	Tretinoin	0-2	signal transducer and activator of transcription 3	Mus musculus	150-155
20595392-4	2010	Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation.	Serine	114-117	signal transducer and activator of transcription 3	Mus musculus	44-49
20595392-4	2010	Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation.	Serine	114-117	signal transducer and activator of transcription 3	Mus musculus	105-110
20595392-5	2010	Additional studies using NEK6 mutants suggested that the phosphorylation on both Ser(206) and Thr(210) of NEK6 is critical for STAT3 phosphorylation and anchorage-independent transformation of mouse epidermal cells.	Serine	81-84	signal transducer and activator of transcription 3	Mus musculus	127-132
20595392-5	2010	Additional studies using NEK6 mutants suggested that the phosphorylation on both Ser(206) and Thr(210) of NEK6 is critical for STAT3 phosphorylation and anchorage-independent transformation of mouse epidermal cells.	Threonine	94-97	signal transducer and activator of transcription 3	Mus musculus	127-132
20595392-6	2010	Notably, knockdown of NEK6 decreased colony formation and STAT3 Ser(727) phosphorylation.	Serine	64-67	signal transducer and activator of transcription 3	Mus musculus	58-63
20595392-7	2010	Based on our findings, the most likely mechanism that can account for this biological effect involves the activation of STAT3 through the phosphorylation on Ser(727).	Serine	157-160	signal transducer and activator of transcription 3	Mus musculus	120-125
20804969-7	2010	We exploited GY118F to increase Jak/Stat3 activity during somatic cell reprogramming.	gy118f	13-19	signal transducer and activator of transcription 3	Mus musculus	36-41
20483353-0	2010	Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	50-55
20483353-0	2010	Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin.	Cisplatin	151-160	signal transducer and activator of transcription 3	Mus musculus	50-55
20483353-1	2010	We have previously shown that the simultaneous exposure of Hep-2 cells to cucurbitacin B and docetaxel significantly enhances anticancer activity of these cells by suppressing Stat3 activation and down-regulating the expression levels of key cell cycle and anti-apoptosis regulators.	cucurbitacin B	74-88	signal transducer and activator of transcription 3	Mus musculus	176-181
20483353-1	2010	We have previously shown that the simultaneous exposure of Hep-2 cells to cucurbitacin B and docetaxel significantly enhances anticancer activity of these cells by suppressing Stat3 activation and down-regulating the expression levels of key cell cycle and anti-apoptosis regulators.	Docetaxel	93-102	signal transducer and activator of transcription 3	Mus musculus	176-181
20483353-5	2010	More specifically, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3 in comparison with single agent treated cells.	cucurbitacin B	53-67	signal transducer and activator of transcription 3	Mus musculus	138-143
20483353-5	2010	More specifically, Hep-2 cell lines treated with the cucurbitacin B/cisplatin combination demonstrated a significantly reduced level of p-Stat3 in comparison with single agent treated cells.	Cisplatin	68-77	signal transducer and activator of transcription 3	Mus musculus	138-143
20615550-0	2010	Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.	triptolide	0-10	signal transducer and activator of transcription 3	Mus musculus	96-101
20615550-6	2010	We hypothesized that triptolide would attenuate the experimental colitis by repressing IL-17 and that this would involve down-regulation of IL-6/STAT3 signaling pathway.	triptolide	21-31	signal transducer and activator of transcription 3	Mus musculus	145-150
20615550-8	2010	Triptolide suppressed the IL-6/STAT3 signaling pathway, as well as repressed gene expression of IL-17 in vivo.	triptolide	0-10	signal transducer and activator of transcription 3	Mus musculus	31-36
20469933-10	2010	MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells.	Tetradecanoylphorbol Acetate	65-68	signal transducer and activator of transcription 3	Mus musculus	19-24
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Tyrphostins	5-15	signal transducer and activator of transcription 3	Mus musculus	121-126
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	RTKI cpd	16-22	signal transducer and activator of transcription 3	Mus musculus	121-126
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Curcumin	63-71	signal transducer and activator of transcription 3	Mus musculus	94-99
20513444-8	2010	Both Tyrphostin AG1478, an EGFR tyrosine kinase inhibitor, and curcumin, an inhibitor of both STAT3 and EGFR, attenuated STAT3 activation/nuclear translocation, reduced skin thickening, and partially suppressed the barrier abnormalities.	Curcumin	63-71	signal transducer and activator of transcription 3	Mus musculus	121-126
19925559-0	2010	Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis.	Pioglitazone	46-58	signal transducer and activator of transcription 3	Mus musculus	62-67
19925559-5	2010	Immunoblot analysis delineated significant increases in nuclear p-STAT3 levels in non-treated ALS mice as compared with pioglitazone-treated ALS mice and non-treated and pioglitazone-treated control mice.	Pioglitazone	170-182	signal transducer and activator of transcription 3	Mus musculus	66-71
19925559-8	2010	Moreover, it is likely that pioglitazone may exert inhibitory effects on STAT3-mediated proinflammtory mechanisms in this disease.	Pioglitazone	28-40	signal transducer and activator of transcription 3	Mus musculus	73-78
20564347-7	2010	Adiponectin treatment of MC-38 cells did not inhibit insulin-induced cell proliferation but did inhibit IL-6-induced cell proliferation by decreasing STAT-3 phosphorylation and activation.	mc-38	25-30	signal transducer and activator of transcription 3	Mus musculus	150-156
20193684-1	2010	BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (Stat3) is the main mediator of interleukin-6-type cytokine signaling required for hepatocyte proliferation and hepatoprotection, but its role in sclerosing cholangitis and other cholestatic liver diseases remains unresolved.	Adenosine Monophosphate	12-15	signal transducer and activator of transcription 3	Mus musculus	23-73
20332345-10	2010	Moreover, inhibition of Nox4 attenuated hypoxia-induced upregulation of HIF-1alpha and high-glucose-elicited phosphorylation of STAT3.	Glucose	92-99	signal transducer and activator of transcription 3	Mus musculus	128-133
20193684-1	2010	BACKGROUND & AIMS: Signal transducer and activator of transcription 3 (Stat3) is the main mediator of interleukin-6-type cytokine signaling required for hepatocyte proliferation and hepatoprotection, but its role in sclerosing cholangitis and other cholestatic liver diseases remains unresolved.	Adenosine Monophosphate	12-15	signal transducer and activator of transcription 3	Mus musculus	75-80
20193684-3	2010	RESULTS: We show that conditional inactivation of Stat3 in hepatocytes and cholangiocytes (stat3(Deltahc)) of mdr2(-/-) mice strongly aggravated bile acid-induced liver injury and fibrosis.	Bile Acids and Salts	145-154	signal transducer and activator of transcription 3	Mus musculus	50-55
19603526-6	2010	We found that the translocation of vitamin D3 from cytoplasm to the nucleus is transient, as the maximal nuclear concentration is reached after 10 h of incubation with (3)H-vitamin D3 and decreases to control values by 12 h. The appearance of differentiation markers such as Bcl2, NGF, STAT3, and the decrease of proliferation markers such as cyclin-1 and PCNA are late events.	Cholecalciferol	35-45	signal transducer and activator of transcription 3	Mus musculus	286-291
20193684-3	2010	RESULTS: We show that conditional inactivation of Stat3 in hepatocytes and cholangiocytes (stat3(Deltahc)) of mdr2(-/-) mice strongly aggravated bile acid-induced liver injury and fibrosis.	Bile Acids and Salts	145-154	signal transducer and activator of transcription 3	Mus musculus	91-96
20193684-7	2010	Moreover, Stat3-deficient hepatocytes displayed up-regulation of bile acid biosynthesis genes and down-regulation of hepatoprotective epidermal growth factor receptor and insulin-like growth factor 1 signaling pathways.	Bile Acids and Salts	65-74	signal transducer and activator of transcription 3	Mus musculus	10-15
20193684-8	2010	Consistently, stat3(Deltahc) mice were more sensitive to cholic acid-induced liver damage than control mice.	Cholic Acid	57-68	signal transducer and activator of transcription 3	Mus musculus	14-19
20211986-8	2010	During the early stages of liver repair after CCl(4) treatment, we observed overproduction of TNFalpha and a strong decrease of phosphorylation and DNA-binding activity of signal transducer and activator of transcription 3 in livers from FXR(-/-) mice.	Cefaclor	46-49	signal transducer and activator of transcription 3	Mus musculus	172-222
20196117-0	2010	Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice.	Carbon Tetrachloride	77-97	signal transducer and activator of transcription 3	Mus musculus	123-173
20196117-2	2010	Investigating the cellular mechanisms underlying these events using an experimental animal model, we show that inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl(4)) in myeloid-specific signal transducer and activator of transcription 3 (STAT3) knockout mice.	Carbon Tetrachloride	164-184	signal transducer and activator of transcription 3	Mus musculus	214-264
20196117-2	2010	Investigating the cellular mechanisms underlying these events using an experimental animal model, we show that inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl(4)) in myeloid-specific signal transducer and activator of transcription 3 (STAT3) knockout mice.	Carbon Tetrachloride	164-184	signal transducer and activator of transcription 3	Mus musculus	266-271
20196117-2	2010	Investigating the cellular mechanisms underlying these events using an experimental animal model, we show that inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl(4)) in myeloid-specific signal transducer and activator of transcription 3 (STAT3) knockout mice.	Cefaclor	186-189	signal transducer and activator of transcription 3	Mus musculus	214-264
20196117-2	2010	Investigating the cellular mechanisms underlying these events using an experimental animal model, we show that inflammation may attenuate liver necrosis induced by carbon tetrachloride (CCl(4)) in myeloid-specific signal transducer and activator of transcription 3 (STAT3) knockout mice.	Cefaclor	186-189	signal transducer and activator of transcription 3	Mus musculus	266-271
20196117-3	2010	As an important anti-inflammatory signal, conditional deletion of STAT3 in myeloid cells results in markedly enhanced liver inflammation after CCl(4) injection.	Cefaclor	143-146	signal transducer and activator of transcription 3	Mus musculus	66-71
20196117-6	2010	CONCLUSION: Inflammation-mediated STAT3 activation attenuates hepatocellular injury induced by CCl(4) in myeloid-specific STAT3 knockout mice, suggesting that inflammation associated with a predominance of hepatoprotective cytokines that activate hepatic STAT3 may reduce rather than accelerate hepatocellular damage in patients with chronic liver diseases.	Cefaclor	95-98	signal transducer and activator of transcription 3	Mus musculus	34-39
20196117-6	2010	CONCLUSION: Inflammation-mediated STAT3 activation attenuates hepatocellular injury induced by CCl(4) in myeloid-specific STAT3 knockout mice, suggesting that inflammation associated with a predominance of hepatoprotective cytokines that activate hepatic STAT3 may reduce rather than accelerate hepatocellular damage in patients with chronic liver diseases.	Cefaclor	95-98	signal transducer and activator of transcription 3	Mus musculus	122-127
20196117-6	2010	CONCLUSION: Inflammation-mediated STAT3 activation attenuates hepatocellular injury induced by CCl(4) in myeloid-specific STAT3 knockout mice, suggesting that inflammation associated with a predominance of hepatoprotective cytokines that activate hepatic STAT3 may reduce rather than accelerate hepatocellular damage in patients with chronic liver diseases.	Cefaclor	95-98	signal transducer and activator of transcription 3	Mus musculus	122-127
20215335-3	2010	We here showed that Zn suppresses T(h)17-mediated autoimmune diseases at lest in part by inhibiting the development of T(h)17 cells via attenuating STAT3 activation.	Zinc	20-22	signal transducer and activator of transcription 3	Mus musculus	148-153
20215335-5	2010	IL-6-mediated activation of STAT3 and in vitro T(h)17 cell development were all suppressed by Zn.	Zinc	94-96	signal transducer and activator of transcription 3	Mus musculus	28-33
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	73-78
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	110-115
20215335-6	2010	Importantly, Zn binding changed the alpha-helical secondary structure of STAT3, disrupting the association of STAT3 with JAK2 kinase and with a phospho-peptide that included a STAT3-binding motif from the IL-6 signal transducer gp130.	Zinc	13-15	signal transducer and activator of transcription 3	Mus musculus	110-115
20215335-7	2010	Thus, we conclude that Zn suppresses STAT3 activation, which is a critical step for T(h)17 development.	Zinc	23-25	signal transducer and activator of transcription 3	Mus musculus	37-42
20421975-2	2010	Treatment with Na(3)VO(4) desensitized keratinocytes to UVB-induced apoptosis with the recovery of phosphorylated Stat3 protein levels, implying that a protein tyrosine phosphatase (PTP) is involved in this mechanism.	na(3)vo(	15-23	signal transducer and activator of transcription 3	Mus musculus	114-119
20030320-0	2010	Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy.	Polylactic Acid-Polyglycolic Acid Copolymer	17-50	signal transducer and activator of transcription 3	Mus musculus	79-84
20030320-0	2010	Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy.	cucurbitacin I	95-102	signal transducer and activator of transcription 3	Mus musculus	79-84
20484629-5	2010	We find that tyrosine phosphorylation of STAT3 is elevated in the cortex and hippocampus of APP/PS1 transgenic mice.	Tyrosine	13-21	signal transducer and activator of transcription 3	Mus musculus	41-46
20484629-6	2010	Treatment of cultured rat neurons with Abeta or intrahippocampal injection of mice with Abeta both induces tyrosine phosphorylation of STAT3 in neurons.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	135-140
20151299-4	2010	RESULTS: Inhibition of PKCdelta by rottlerin significantly reduced both Ser-727 and Tyr-705 phosphorylation of STAT3.	rottlerin	35-44	signal transducer and activator of transcription 3	Mus musculus	111-116
20151299-4	2010	RESULTS: Inhibition of PKCdelta by rottlerin significantly reduced both Ser-727 and Tyr-705 phosphorylation of STAT3.	Tyrosine	84-87	signal transducer and activator of transcription 3	Mus musculus	111-116
20169331-9	2010	STAT3 inhibitors, including curcumin, AG490 and a peptide (PpYLKTK), reduced hepcidin1 mRNA expression even when cells were additionally exposed to IL-6.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	0-5
20084083-4	2010	Further study showed that high doses of alpha-GC directly enhance the Th17 and Th1 response by activation of CD4(+)CD44(+) memory T cells through phosphorylation of STAT3 and activation of NF-kappaB.	alpha-galactosylceramide	40-48	signal transducer and activator of transcription 3	Mus musculus	165-170
20022531-11	2010	RESULTS: GH was able to induce STAT5 and STAT3 tyrosine phosphorylation in both liver and muscle, but the response was higher for Ames dwarf mice than for non-dwarf controls.	Tyrosine	47-55	signal transducer and activator of transcription 3	Mus musculus	41-46
20039267-0	2010	Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK/STAT signaling in C3H10T1/2 cells.	Dexamethasone	33-46	signal transducer and activator of transcription 3	Mus musculus	112-116
20039267-7	2010	A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex.	Dexamethasone	253-256	signal transducer and activator of transcription 3	Mus musculus	117-167
20039267-7	2010	A luciferase assay using ALP promoter deletion constructs showed that a region of the promoter containing a putative signal transducer and activator of transcription 3 (STAT3) response element (SRE) responds to treatment with a combination of BMP-2 and Dex.	Dexamethasone	253-256	signal transducer and activator of transcription 3	Mus musculus	169-174
20039267-9	2010	In addition, a STAT3 siRNA suppressed the synergistic effect of BMP-2 and Dex on ALP levels.	Dexamethasone	74-77	signal transducer and activator of transcription 3	Mus musculus	15-20
20039267-11	2010	To our knowledge, this is the first time that STAT3 has been implicated in the regulation of ALP expression by BMP-2 and Dex.	Dexamethasone	121-124	signal transducer and activator of transcription 3	Mus musculus	46-51
20080963-6	2010	Stimulation of D2R by the D2R agonist quinpirole suppressed the leptin-induced STAT3 phosphorylation and nuclear trans-localization of phospho-STAT3 in the hypothalamus of wild type mice.	Quinpirole	38-48	signal transducer and activator of transcription 3	Mus musculus	79-84
20080963-6	2010	Stimulation of D2R by the D2R agonist quinpirole suppressed the leptin-induced STAT3 phosphorylation and nuclear trans-localization of phospho-STAT3 in the hypothalamus of wild type mice.	Quinpirole	38-48	signal transducer and activator of transcription 3	Mus musculus	143-148
19852956-6	2010	In addition, Rac(V12)-expressing cells had higher Stat3, tyrosine-705 phosphorylation and activity levels at all densities, indicating that Rac(V12) is able to activate Stat3.	Tyrosine	57-65	signal transducer and activator of transcription 3	Mus musculus	169-174
20211986-9	2010	Exogenous expression of a constitutively active signal transducer and activator of transcription 3 protein in FXR(-/-) liver effectively reduced hepatocyte death and liver injury after CCl(4) treatment.	Cefaclor	185-188	signal transducer and activator of transcription 3	Mus musculus	48-98
20124472-5	2010	We further showed that signal transducer and activator of transcription-3 (STAT3), the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and neural stem cells, mouse glioma cells, and human MPNST cells through Ser(727) phosphorylation, leading to increased cyclin D1 expression.	cucurbitacin I	97-111	signal transducer and activator of transcription 3	Mus musculus	23-73
19028402-6	2010	High cholesterol-diet feeding increases the activity of NADPH oxidase subunits (p47(phox) and Rac), extracellular signal-regulated kinase 1/2, janus kinase 2, signal transducer and activator of transcription 3, nuclear factor-kappaB and the expression of tumor necrosis factor-alpha, interleukin 6, monocyte chemoattactant protein-1 and vascular cell adhesion molecule-1 in the aortas.	Cholesterol	5-16	signal transducer and activator of transcription 3	Mus musculus	159-209
20207848-5	2010	Further studies of SEC31A-ALK showed that this variant fusion transforms IL3-dependent Ba/F3 cells to growth factor independence, and that the ALK inhibitor TAE-684 reduces cell proliferation and kinase activity of SEC31A-ALK and its downstream effectors ERK1/2, AKT, STAT3 and STAT5.	NVP-TAE684	157-164	signal transducer and activator of transcription 3	Mus musculus	268-273
20030320-3	2010	Herein we describe the development of a polymeric nanocarrier for the delivery of JSI-124 (a small molecule inhibitor of STAT3) to tumor and immunosuppressed DCs using poly(d,l-lactic-co-glycolic acid) nanoparticles (PLGA NPs).	cucurbitacin I	82-89	signal transducer and activator of transcription 3	Mus musculus	121-126
20124472-5	2010	We further showed that signal transducer and activator of transcription-3 (STAT3), the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and neural stem cells, mouse glioma cells, and human MPNST cells through Ser(727) phosphorylation, leading to increased cyclin D1 expression.	cucurbitacin I	97-111	signal transducer and activator of transcription 3	Mus musculus	75-80
20124472-5	2010	We further showed that signal transducer and activator of transcription-3 (STAT3), the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and neural stem cells, mouse glioma cells, and human MPNST cells through Ser(727) phosphorylation, leading to increased cyclin D1 expression.	Serine	252-255	signal transducer and activator of transcription 3	Mus musculus	23-73
20124472-5	2010	We further showed that signal transducer and activator of transcription-3 (STAT3), the target of cucurbitacin-I inhibition, was hyperactivated in NF1-deficient primary astrocytes and neural stem cells, mouse glioma cells, and human MPNST cells through Ser(727) phosphorylation, leading to increased cyclin D1 expression.	Serine	252-255	signal transducer and activator of transcription 3	Mus musculus	75-80
19913908-0	2010	The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine.	Polyethyleneimine	105-121	signal transducer and activator of transcription 3	Mus musculus	59-64
20332450-5	2010	RESULTS: Combined treatment of 3 microM gamma-tocotrienol with 0.25 microM erlotinib or 0.5 microM gefitinib significantly inhibited +SA cell growth and reduced cyclin D1 and phosphorylated (active) Pdk-1, Akt, Stat3 and Stat5 levels.	plastochromanol 8	40-57	signal transducer and activator of transcription 3	Mus musculus	211-216
20332450-5	2010	RESULTS: Combined treatment of 3 microM gamma-tocotrienol with 0.25 microM erlotinib or 0.5 microM gefitinib significantly inhibited +SA cell growth and reduced cyclin D1 and phosphorylated (active) Pdk-1, Akt, Stat3 and Stat5 levels.	Erlotinib Hydrochloride	75-84	signal transducer and activator of transcription 3	Mus musculus	211-216
20332450-5	2010	RESULTS: Combined treatment of 3 microM gamma-tocotrienol with 0.25 microM erlotinib or 0.5 microM gefitinib significantly inhibited +SA cell growth and reduced cyclin D1 and phosphorylated (active) Pdk-1, Akt, Stat3 and Stat5 levels.	Gefitinib	99-108	signal transducer and activator of transcription 3	Mus musculus	211-216
20091060-2	2010	Hepcidin, mainly produced by hepatocytes in a STAT3- and/or SMAD-dependent manner, is involved in iron homeostasis.	Iron	98-102	signal transducer and activator of transcription 3	Mus musculus	46-51
20008137-6	2010	Moreover, in IL-6(-/-) mice treated with NaAs, ACD in renal tubular cells was significantly augmented, along with diminished STAT3 activation and reciprocal enhancement of ERK signaling, compared with wild-type mice.	naas	41-45	signal transducer and activator of transcription 3	Mus musculus	125-130
20008137-8	2010	Thus, IL-6/STAT3 signal pathway could inhibit ERK activation, a crucial step for ACD, eventually attenuating NaAs-induced renal dysfunction.	naas	109-113	signal transducer and activator of transcription 3	Mus musculus	11-16
19796711-0	2010	Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling.	Resveratrol	38-49	signal transducer and activator of transcription 3	Mus musculus	64-69
19796711-4	2010	Our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (Jurkat, SUP-B15, and Kasumi-1), and reducing the phosphorylation of STAT3, meanwhile modulating the expression of Bcl-2 and Bax.	Resveratrol	23-34	signal transducer and activator of transcription 3	Mus musculus	212-217
19796711-5	2010	In vivo, resveratrol could prolong the life span of Kasumi-1-bearing mice, and attenuate the activity of STAT3.	Resveratrol	9-20	signal transducer and activator of transcription 3	Mus musculus	105-110
19796711-6	2010	Taken altogether, this investigation focuses on signaling pathways involved in STAT3 by resveratrol and to delineate its molecular mechanisms underlying anti-leukemia effect.	Resveratrol	88-99	signal transducer and activator of transcription 3	Mus musculus	79-84
19688830-6	2010	The dietary administration with GOFA/beta-CD and AUR/beta-CD inhibited colonic inflammation and also modulated proliferation, apoptosis and the expression of several proinflammatory cytokines, such as nuclear factor-kappaB, tumor necrosis factor-alpha, Stat3, NF-E2-related factor 2, interleukin (IL)-6 and IL-1beta, which were induced in the adenocarcinomas.	gofa	32-36	signal transducer and activator of transcription 3	Mus musculus	253-258
19913908-2	2010	In this study, we investigated the potential of nanoparticles based on polyethylenimine (PEI) modified with stearic acid (StA), to deliver siRNA for efficient STAT3 downregulation in B16 melanoma cells.	stearic acid	122-125	signal transducer and activator of transcription 3	Mus musculus	159-164
19831872-8	2010	Taurine significantly decreased IL-6 and MPO levels in a dose-dependent manner, significantly reducing the phosphorylation of STAT3 and expression of COX-2 after SCI compared to controls.	Taurine	0-7	signal transducer and activator of transcription 3	Mus musculus	126-131
19997066-6	2010	Importantly, LPS/GalN-induced hepatic Stat3 survival signaling was impaired and early activation of Jak2 was delayed in PXR-null mice.	Galactosamine	17-21	signal transducer and activator of transcription 3	Mus musculus	38-43
19997066-7	2010	Expression levels of pro-survival proteins Bcl-xL and heme oxygenase-1 (HO-1), which are downstream of Stat3, were substantially lower in PXR-null than wild-type mouse livers after LPS/GalN treatment.	Galactosamine	185-189	signal transducer and activator of transcription 3	Mus musculus	103-108
19997066-12	2010	Increases of LPS/GalN-induced hepatocyte apoptosis and liver injury in PXR-null mice are due to deregulated mitogen-activated protein (MAP) kinase activation as well as delayed Jak2/Stat3 activation, which lead to a compromise in defense mechanisms that involve Bcl-xL-, HO-1, and autophagy-mediated pathways.	Galactosamine	17-21	signal transducer and activator of transcription 3	Mus musculus	182-187
20008137-2	2010	The inhibition of the IL-6/signal transducer and activator of transcription 3 (STAT3) signal pathway by anti-IL-6 antibody or a Jak2 inhibitor (AG490) exaggerated ACD of mProx24 cells after NaAs challenge, attenuating STAT3 activation and reciprocally enhancing extracellular signal-regulated kinase (ERK) phosphorylation.	naas	190-194	signal transducer and activator of transcription 3	Mus musculus	27-77
20008137-2	2010	The inhibition of the IL-6/signal transducer and activator of transcription 3 (STAT3) signal pathway by anti-IL-6 antibody or a Jak2 inhibitor (AG490) exaggerated ACD of mProx24 cells after NaAs challenge, attenuating STAT3 activation and reciprocally enhancing extracellular signal-regulated kinase (ERK) phosphorylation.	naas	190-194	signal transducer and activator of transcription 3	Mus musculus	79-84
19913908-2	2010	In this study, we investigated the potential of nanoparticles based on polyethylenimine (PEI) modified with stearic acid (StA), to deliver siRNA for efficient STAT3 downregulation in B16 melanoma cells.	Polyethyleneimine	71-87	signal transducer and activator of transcription 3	Mus musculus	159-164
19913908-2	2010	In this study, we investigated the potential of nanoparticles based on polyethylenimine (PEI) modified with stearic acid (StA), to deliver siRNA for efficient STAT3 downregulation in B16 melanoma cells.	Polyethyleneimine	89-92	signal transducer and activator of transcription 3	Mus musculus	159-164
19913908-2	2010	In this study, we investigated the potential of nanoparticles based on polyethylenimine (PEI) modified with stearic acid (StA), to deliver siRNA for efficient STAT3 downregulation in B16 melanoma cells.	stearic acid	108-120	signal transducer and activator of transcription 3	Mus musculus	159-164
20014282-2	2010	LIF induces overexpression and tyrosine phosphorylation of STAT3 (signal transducer and activator of transcription 3) and its subsequent nuclear translocation.	Tyrosine	31-39	signal transducer and activator of transcription 3	Mus musculus	59-64
20014282-2	2010	LIF induces overexpression and tyrosine phosphorylation of STAT3 (signal transducer and activator of transcription 3) and its subsequent nuclear translocation.	Tyrosine	31-39	signal transducer and activator of transcription 3	Mus musculus	66-116
19736311-4	2009	15(S)-HETE also induced monocyte chemoattractant protein-1 (MCP-1) expression via Src-STAT-3 signaling, and neutralizing anti-MCP-1 antibodies completely negated 15(S)-HETE-induced VSMC migration.	Hydroxyeicosatetraenoic Acids	6-10	signal transducer and activator of transcription 3	Mus musculus	86-92
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	Tyrosine	183-191	signal transducer and activator of transcription 3	Mus musculus	116-121
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	Tyrosine	183-191	signal transducer and activator of transcription 3	Mus musculus	158-163
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	Tyrosine	183-191	signal transducer and activator of transcription 3	Mus musculus	158-163
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	phenylanaine	238-250	signal transducer and activator of transcription 3	Mus musculus	116-121
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	phenylanaine	238-250	signal transducer and activator of transcription 3	Mus musculus	158-163
20814592-3	2010	We report here that in murine B16 melanoma cells, which have been previously shown to express constitutively active STAT3, the expression of a mutant form of STAT3 with the canonical tyrosine phosphorylation site (residue 705) mutated to phenylanaine has dominant-negative properties (STAT3-DN).	phenylanaine	238-250	signal transducer and activator of transcription 3	Mus musculus	158-163
20814592-4	2010	STAT3-DN inhibits STAT3 tyrosine phosphorylation and STAT3-dependent DNA binding activity.	Tyrosine	24-32	signal transducer and activator of transcription 3	Mus musculus	0-5
20814592-4	2010	STAT3-DN inhibits STAT3 tyrosine phosphorylation and STAT3-dependent DNA binding activity.	Tyrosine	24-32	signal transducer and activator of transcription 3	Mus musculus	18-23
20814592-4	2010	STAT3-DN inhibits STAT3 tyrosine phosphorylation and STAT3-dependent DNA binding activity.	Tyrosine	24-32	signal transducer and activator of transcription 3	Mus musculus	18-23
19400741-5	2010	This up-regulation of Nanog can be abolished by NgR inhibitor PI-PLC and NEP1-40, or phospho-Stat3 inhibitor AG490 and rapamycin.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	109-114	signal transducer and activator of transcription 3	Mus musculus	93-98
19736311-6	2009	Rat carotid arteries that were subjected to balloon injury and transduced with Ad-15-LOX1 upon exposure to [(3)H]arachidonic acid ex vivo produced 15-HETE as a major eicosanoid and enhanced balloon injury-induced expression of MCP-1 in smooth muscle cells in Src and STAT-3-dependent manner in vivo.	[(3)h]arachidonic acid	107-129	signal transducer and activator of transcription 3	Mus musculus	267-273
19736311-6	2009	Rat carotid arteries that were subjected to balloon injury and transduced with Ad-15-LOX1 upon exposure to [(3)H]arachidonic acid ex vivo produced 15-HETE as a major eicosanoid and enhanced balloon injury-induced expression of MCP-1 in smooth muscle cells in Src and STAT-3-dependent manner in vivo.	15-hydroxy-5,8,11,13-eicosatetraenoic acid	147-154	signal transducer and activator of transcription 3	Mus musculus	267-273
19666677-2	2009	We propose that IPostC confers its infarct-sparing effect via activation of the newly described prosurvival Survivor Activating Factor Enhancement (SAFE) pathway, which involves the activation of the cytokine tumour necrosis factor alpha (TNFalpha) and signal transducer and activator of transcription-3 (STAT-3).	ipostc	16-22	signal transducer and activator of transcription 3	Mus musculus	253-303
19666677-2	2009	We propose that IPostC confers its infarct-sparing effect via activation of the newly described prosurvival Survivor Activating Factor Enhancement (SAFE) pathway, which involves the activation of the cytokine tumour necrosis factor alpha (TNFalpha) and signal transducer and activator of transcription-3 (STAT-3).	ipostc	16-22	signal transducer and activator of transcription 3	Mus musculus	305-311
19666677-7	2009	AG490, an inhibitor of STAT-3, abrogated the protective effect of TNFalpha.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	23-29
19823036-0	2009	Uniquely modified RNA oligonucleotides targeting STAT3 suppress melanoma growth both in vitro and in vivo.	Oligonucleotides	22-38	signal transducer and activator of transcription 3	Mus musculus	49-54
19823036-3	2009	In this study, a novel antisense RNA oligonucleotides targeting the STAT3 mRNA was 2"-O-methyl modified with a 3"-butanol tag was designed, and found this uniquely modified strategy dramatic increased the stability of the RNA oligonucleotides.	2"-o-methyl	83-94	signal transducer and activator of transcription 3	Mus musculus	68-73
19823036-3	2009	In this study, a novel antisense RNA oligonucleotides targeting the STAT3 mRNA was 2"-O-methyl modified with a 3"-butanol tag was designed, and found this uniquely modified strategy dramatic increased the stability of the RNA oligonucleotides.	Butanols	114-121	signal transducer and activator of transcription 3	Mus musculus	68-73
19821529-7	2009	NO and FCCP also inhibited TGF-beta1-induced STAT3 activation, suggesting that signal transducer and activator of transcription 3 inactivation is involved in the NO-induced effects on TGF-beta1-induced EMT and apoptosis.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	7-11	signal transducer and activator of transcription 3	Mus musculus	45-50
19821529-7	2009	NO and FCCP also inhibited TGF-beta1-induced STAT3 activation, suggesting that signal transducer and activator of transcription 3 inactivation is involved in the NO-induced effects on TGF-beta1-induced EMT and apoptosis.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	7-11	signal transducer and activator of transcription 3	Mus musculus	79-129
19577074-8	2009	Administration of 17beta-estradiol or estrogen receptor-alpha agonist (not estrogen receptor-beta agonist) elevated mesenchymal stem cell vascular endothelial growth factor, hypoxia inducible factor-1alpha expression, and signal transducer and activator of transcription 3 activation.	Estradiol	18-34	signal transducer and activator of transcription 3	Mus musculus	222-272
19710241-0	2009	Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways.	Hydrogen Peroxide	56-73	signal transducer and activator of transcription 3	Mus musculus	114-119
19710241-8	2009	Inhibition of either the AKT or STAT3 pathway potentiated H2O2-induced cell death and increased GSK-3beta activity by dephosphorylation at serine 9.	Hydrogen Peroxide	58-62	signal transducer and activator of transcription 3	Mus musculus	32-37
19710241-8	2009	Inhibition of either the AKT or STAT3 pathway potentiated H2O2-induced cell death and increased GSK-3beta activity by dephosphorylation at serine 9.	Serine	139-145	signal transducer and activator of transcription 3	Mus musculus	32-37
19740306-11	2009	In the IBD model, ingestion of LcS improved ileitis and inhibited activation of IL-6/STAT3 signaling, while ingestion of the LC(DeltaPSPG-I) strain did not.	lcs	31-34	signal transducer and activator of transcription 3	Mus musculus	85-90
19565565-5	2009	We further demonstrate that this NFATc1-induced autocrine factor(s) specifically induces the tyrosine phosphorylation of the Stat3 transcription factor via a JAK kinase-dependent pathway.	Tyrosine	93-101	signal transducer and activator of transcription 3	Mus musculus	125-130
19490362-5	2009	We demonstrate that small interfering RNA-mediated knockdown of TRAP1 in a neuronal cell line decreases tyrosine phosphorylation of STAT3, followed by a reduction of the transcription factor E2F1, resulting in a down-regulation of N-cadherin, and affects the adhesive properties of the cells.	Tyrosine	104-112	signal transducer and activator of transcription 3	Mus musculus	132-137
19561401-0	2009	Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.	triptolide	0-10	signal transducer and activator of transcription 3	Mus musculus	42-47
19561401-9	2009	Secretion of IL6 and levels of JAK1, IL6R and phosphorylated STAT3 were all reduced by triptolide treatment.	triptolide	87-97	signal transducer and activator of transcription 3	Mus musculus	61-66
19738054-2	2009	Targeted disruption of signal transducer and activator of transcription 3 (Stat3) in bulge region KSCs was achieved by treating K15.CrePR1 x Stat3(fl/fl) mice with RU486.	Mifepristone	164-169	signal transducer and activator of transcription 3	Mus musculus	23-73
19738054-2	2009	Targeted disruption of signal transducer and activator of transcription 3 (Stat3) in bulge region KSCs was achieved by treating K15.CrePR1 x Stat3(fl/fl) mice with RU486.	Mifepristone	164-169	signal transducer and activator of transcription 3	Mus musculus	75-80
19738054-3	2009	Deletion of Stat3 prior to skin tumor initiation with 7,12-dimethylbenz(a)anthracene significantly increased the number of apoptotic KSCs and decreased the frequency of Ha-ras codon 61 A(182)-->T transversion mutations in this cell population compared with wild-type littermates.	7,12-dimethylbenz	54-71	signal transducer and activator of transcription 3	Mus musculus	12-17
19738054-3	2009	Deletion of Stat3 prior to skin tumor initiation with 7,12-dimethylbenz(a)anthracene significantly increased the number of apoptotic KSCs and decreased the frequency of Ha-ras codon 61 A(182)-->T transversion mutations in this cell population compared with wild-type littermates.	anthracene	74-84	signal transducer and activator of transcription 3	Mus musculus	12-17
19738054-4	2009	Targeted disruption of Stat3 in bulge region KSCs at the time of initiation also dramatically reduced the number of skin tumors (by approximately 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Phorbol Esters	189-202	signal transducer and activator of transcription 3	Mus musculus	23-28
19738054-4	2009	Targeted disruption of Stat3 in bulge region KSCs at the time of initiation also dramatically reduced the number of skin tumors (by approximately 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.	Tetradecanoylphorbol Acetate	203-239	signal transducer and activator of transcription 3	Mus musculus	23-28
19789299-0	2009	All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis.	Tretinoin	10-23	signal transducer and activator of transcription 3	Mus musculus	35-40
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	44-57	signal transducer and activator of transcription 3	Mus musculus	117-167
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	44-57	signal transducer and activator of transcription 3	Mus musculus	169-174
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	59-63	signal transducer and activator of transcription 3	Mus musculus	117-167
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Tretinoin	59-63	signal transducer and activator of transcription 3	Mus musculus	169-174
19789299-2	2009	We have determined the effects of all-trans retinoic acid (ATRA), a naturally occurring chemopreventive retinoid, on signal transducer and activator of transcription 3 (Stat3) signaling during the development of skin SCC.	Retinoids	104-112	signal transducer and activator of transcription 3	Mus musculus	169-174
19789299-8	2009	Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice.	Tretinoin	122-126	signal transducer and activator of transcription 3	Mus musculus	206-211
19789299-8	2009	Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice.	Tetradecanoylphorbol Acetate	142-178	signal transducer and activator of transcription 3	Mus musculus	206-211
19789299-10	2009	We hypothesize that ATRA blocks tumor formation, at least in part, by targeting events upstream of Stat3, such as the B-Raf/Mek/Erk pathway, and that in the K5.Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation.	Tretinoin	20-24	signal transducer and activator of transcription 3	Mus musculus	99-104
19789299-10	2009	We hypothesize that ATRA blocks tumor formation, at least in part, by targeting events upstream of Stat3, such as the B-Raf/Mek/Erk pathway, and that in the K5.Stat3C mice, in which Stat3 activity is constitutive, it cannot suppress tumor formation.	Tretinoin	20-24	signal transducer and activator of transcription 3	Mus musculus	160-165
19808018-2	2009	Here, we demonstrate that palmitate acting in the central nervous system (CNS) inhibits leptin-induced anorexia and Stat3 activation.	Palmitates	26-35	signal transducer and activator of transcription 3	Mus musculus	116-121
19306372-8	2009	Inhibition of Stat3 by CPA-7 or siRNA reversed glioma-induced cytokine expression profile in N9 cells.	cpa-7	23-28	signal transducer and activator of transcription 3	Mus musculus	14-19
19759305-5	2009	This unexpected finding coincides with POMC-cell-specific, Stat3-mediated upregulation of SOCS3 expression inhibiting both leptin and insulin signaling as insulin-stimulated PIP(3) (phosphatidylinositol-3,4,5 triphosphate) formation and protein kinase B (AKT) activation in POMC neurons as well as with the fact that insulin"s ability to hyperpolarize POMC neurons is largely reduced in POMC cells of Stat3-C(POMC) mice.	pip(3)	174-180	signal transducer and activator of transcription 3	Mus musculus	59-64
19759305-5	2009	This unexpected finding coincides with POMC-cell-specific, Stat3-mediated upregulation of SOCS3 expression inhibiting both leptin and insulin signaling as insulin-stimulated PIP(3) (phosphatidylinositol-3,4,5 triphosphate) formation and protein kinase B (AKT) activation in POMC neurons as well as with the fact that insulin"s ability to hyperpolarize POMC neurons is largely reduced in POMC cells of Stat3-C(POMC) mice.	phosphatidylinositol 3,4,5-triphosphate	182-221	signal transducer and activator of transcription 3	Mus musculus	59-64
19608979-7	2009	During the early preconditioning period, H(2)S increased the nuclear localization of Nrf2, a transcription factor that regulates the gene expression of a number of antioxidants and increased the phosphorylation of protein kinase Cepsilon and STAT-3.	Hydrogen Sulfide	41-46	signal transducer and activator of transcription 3	Mus musculus	242-248
19564350-4	2009	Studies in genetically engineered mice showed that epithelial STAT3 activation in dextran sodium sulfate colitis is dependent on interleukin (IL)-22 rather than IL-6.	dextran sodium sulfate	82-104	signal transducer and activator of transcription 3	Mus musculus	62-67
19375967-6	2009	Further study revealed that MPS VII growth plates had reduced tyrosine phosphorylation of STAT3, a pro-proliferative transcription factor.	Tyrosine	62-70	signal transducer and activator of transcription 3	Mus musculus	90-95
19375967-9	2009	This suggests that accumulation of C4S in the growth plate leads to reduced expression of LIF and reduced STAT3 tyrosine phosphorylation, which results in reduced chondrocyte proliferation and ultimately shortened bones.	Chondroitin Sulfates	35-38	signal transducer and activator of transcription 3	Mus musculus	106-111
19375967-9	2009	This suggests that accumulation of C4S in the growth plate leads to reduced expression of LIF and reduced STAT3 tyrosine phosphorylation, which results in reduced chondrocyte proliferation and ultimately shortened bones.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	106-111
19577074-11	2009	CONCLUSION: 17beta-estradiol-induced vascular endothelial growth factor production from mesenchymal stem cells appears to be mediated through estrogen receptor-alpha-activated signal transducer and activator of transcription 3-mediated hypoxia inducible factor-1alpha expression.	Estradiol	12-28	signal transducer and activator of transcription 3	Mus musculus	176-226
18798092-0	2009	Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124.	cucurbitacin I	120-127	signal transducer and activator of transcription 3	Mus musculus	103-108
19474327-9	2009	Moreover, we found that STAT3 deactivated by reperfusion induces accumulation of O(2)(*-) in mitochondria.	Superoxides	81-85	signal transducer and activator of transcription 3	Mus musculus	24-29
19474327-12	2009	Our study demonstrates that STAT3 is a novel transcription factor of the mouse Mn-SOD gene and plays a crucial role as a neuroprotectant in regulating levels of reactive oxygen species in the mouse brain.	Reactive Oxygen Species	161-184	signal transducer and activator of transcription 3	Mus musculus	28-33
19144959-11	2009	PEGIL11A significantly diminished STAT3 phosphorylation in HES cells in vitro (P < or = 0.05).	pegil11a	0-8	signal transducer and activator of transcription 3	Mus musculus	34-39
19299019-5	2009	Knockdown of STAT3 expression via small interfering RNA (siRNA) decreased the level of STAT3 expression in Raw 264.7 cells and decreased STAT3 tyrosine phosphorylation in response to LPS treatment.	Tyrosine	143-151	signal transducer and activator of transcription 3	Mus musculus	13-18
19299019-9	2009	These results highlight the complex role of STAT3 in cytokine production and the key role of STAT3 tyrosine phosphorylation in IL-1beta and IL-6 production in response to inflammation.	Tyrosine	99-107	signal transducer and activator of transcription 3	Mus musculus	93-98
19416544-15	2009	These beneficial effects of AG-490 were related to lowered levels of circulating IL-6, MIP-1alpha and C5a, and to inhibited expression of STAT1, STAT3 and C5aR in kidneys.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-34	signal transducer and activator of transcription 3	Mus musculus	145-150
18795895-5	2009	RESULTS: In cultured CFBs, APN (10 microg/ml) can significantly induce delayed STAT3 Tyr(705) phosphorylation time-dependently, up to 60 min, and mediate STAT3 translocation from cytoplasm to nucleus.	Tyrosine	85-88	signal transducer and activator of transcription 3	Mus musculus	79-84
18795895-6	2009	Transfection of siRNA (small interfering RNA) specific for AdipoR1 (APN receptor 1), but not AdipoR2, obviously inhibited APN-induced STAT3 Tyr(705) phosphorylation, indicating that AdipoR1, not AdipoR2, is required for STAT3 phosphorylation.	Tyrosine	140-143	signal transducer and activator of transcription 3	Mus musculus	134-139
18795895-7	2009	Both inhibition of gp130 by anti-gp130 neutralizing antibody and JAK2 by AG490 (a specific inhibitor for JAK2) can inhibit APN-induced STAT3 phosphorylation and STAT3 transcription activity detected using 2 x pAPRE-Luc (APRE reporter) assay.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	73-78	signal transducer and activator of transcription 3	Mus musculus	135-140
18795895-7	2009	Both inhibition of gp130 by anti-gp130 neutralizing antibody and JAK2 by AG490 (a specific inhibitor for JAK2) can inhibit APN-induced STAT3 phosphorylation and STAT3 transcription activity detected using 2 x pAPRE-Luc (APRE reporter) assay.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	73-78	signal transducer and activator of transcription 3	Mus musculus	161-166
18798092-5	2009	In addition the immunomodulatory and anticancer effects of 7-acyl lipid A PLGA-NPs in combination with a STAT3 inhibitory agent, JSI-124, in a B16 mouse melanoma model was explored, in vivo.	cucurbitacin I	129-136	signal transducer and activator of transcription 3	Mus musculus	105-110
19244102-0	2009	Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	24-29
19332876-3	2009	Transforming growth factor (TGF)-beta levels and STAT3 activity were elevated in liver tissue from STAT5-LKO mice upon CCl(4) treatment.	Cefaclor	119-122	signal transducer and activator of transcription 3	Mus musculus	49-54
18621395-10	2009	Post-PH STAT3 activation was recovered by administering vagotomized mice with an ACh agonist.	Acetylcholine	81-84	signal transducer and activator of transcription 3	Mus musculus	8-13
19244102-4	2009	We show that sunitinib induces tumor cell apoptosis and growth arrest in RCC tumor cells, which correlates with signal transducer and activator of transcription 3 (Stat3) activity inhibition.	Sunitinib	13-22	signal transducer and activator of transcription 3	Mus musculus	112-162
19244102-4	2009	We show that sunitinib induces tumor cell apoptosis and growth arrest in RCC tumor cells, which correlates with signal transducer and activator of transcription 3 (Stat3) activity inhibition.	Sunitinib	13-22	signal transducer and activator of transcription 3	Mus musculus	164-169
19244102-6	2009	Reduction of Stat3 activity enhances the antitumor effects of sunitinib, whereas expression of a constitutively activated Stat3 mutant rescues tumor cell death.	Sunitinib	62-71	signal transducer and activator of transcription 3	Mus musculus	13-18
19244102-8	2009	Sunitinib also inhibits Stat3 in Renca tumor-associated myeloid-derived suppressor cells (MDSC), down-regulates angiogenic gene expression, and reduces MDSCs and tumor T regulatory cells.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	24-29
19244102-9	2009	These results suggest that Stat3 activity is important for RCC response to sunitinib, and Stat3 inhibition permits the direct proapoptotic activity of sunitinib on tumor cells and positive effects on tumor immunologic microenvironment.	Sunitinib	75-84	signal transducer and activator of transcription 3	Mus musculus	27-32
19244102-9	2009	These results suggest that Stat3 activity is important for RCC response to sunitinib, and Stat3 inhibition permits the direct proapoptotic activity of sunitinib on tumor cells and positive effects on tumor immunologic microenvironment.	Sunitinib	151-160	signal transducer and activator of transcription 3	Mus musculus	90-95
19071214-7	2009	Treatment with LY294002, a PI3 kinase inhibitor, but not with other signal inhibitors, resulted in the loss of delayed STAT3 phosphorylation by HGF/SF, showing the involvement of PI3 kinase pathway.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	signal transducer and activator of transcription 3	Mus musculus	119-124
20155626-5	2009	Phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-3 (STAT3) was also enhanced after DSS treatment.	Dextran Sulfate	150-153	signal transducer and activator of transcription 3	Mus musculus	67-117
19295512-4	2009	In contrast, signal transducer and activator of transcription 3 (STAT3) inhibits glucose production by suppressing expression of these genes.	Glucose	81-88	signal transducer and activator of transcription 3	Mus musculus	13-63
19295512-4	2009	In contrast, signal transducer and activator of transcription 3 (STAT3) inhibits glucose production by suppressing expression of these genes.	Glucose	81-88	signal transducer and activator of transcription 3	Mus musculus	65-70
19295512-6	2009	Here we show that STAT3 phosphorylation and function in the liver were tightly regulated by the nutritional status of an animal, through SirT1-mediated deacetylation of key STAT3 lysine sites.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	18-23
19295512-6	2009	Here we show that STAT3 phosphorylation and function in the liver were tightly regulated by the nutritional status of an animal, through SirT1-mediated deacetylation of key STAT3 lysine sites.	Lysine	179-185	signal transducer and activator of transcription 3	Mus musculus	173-178
18813209-9	2009	Pharmacological inhibition of the JAK2/STAT3 axis not only induced significant loss of spatial working memory by downregulating an acetylcholine-producing enzyme choline acetyltransferase but also desensitized the M(1)-type muscarinic acetylcholine receptor.	Acetylcholine	131-144	signal transducer and activator of transcription 3	Mus musculus	39-44
18813209-9	2009	Pharmacological inhibition of the JAK2/STAT3 axis not only induced significant loss of spatial working memory by downregulating an acetylcholine-producing enzyme choline acetyltransferase but also desensitized the M(1)-type muscarinic acetylcholine receptor.	Acetylcholine	235-248	signal transducer and activator of transcription 3	Mus musculus	39-44
19027957-9	2009	EPO stimulation of the BM-DCs led to Tyr-phosphorylation of STAT3.	Tyrosine	37-40	signal transducer and activator of transcription 3	Mus musculus	60-65
18940183-5	2009	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Halothane	116-125	signal transducer and activator of transcription 3	Mus musculus	81-85
18940183-5	2009	In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice.	Halothane	116-125	signal transducer and activator of transcription 3	Mus musculus	93-98
19139021-8	2009	Silibinin decreased the phosphorylation of p65NF-kappaB (ser276, 38%; P < 0.01) and STAT-3 (ser727, 16%; P < 0.01) in tumor cells and decreased the lung macrophage population.	Silybin	0-9	signal transducer and activator of transcription 3	Mus musculus	87-93
19139021-10	2009	Therapeutic efficacy of silibinin in lung tumor growth inhibition and regression by antiangiogenic mechanisms seem to be mediated by decreased tumor-associated macrophages and cytokines, inhibition of hypoxia-inducible factor-1 alpha, NF-kappaB, and STAT-3 activation, and up-regulation of the angiogenic inhibitors, Ang-2 and Tie-2.	Silybin	24-33	signal transducer and activator of transcription 3	Mus musculus	250-256
19471105-9	2009	When STAT3 activation was blocked with its inhibitor JSI-124, PHx mice also developed severe liver inflammation after ConA stimulation.	cucurbitacin I	53-60	signal transducer and activator of transcription 3	Mus musculus	5-10
20155626-5	2009	Phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-3 (STAT3) was also enhanced after DSS treatment.	Dextran Sulfate	150-153	signal transducer and activator of transcription 3	Mus musculus	119-124
20155626-6	2009	Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK.	Resveratrol	23-34	signal transducer and activator of transcription 3	Mus musculus	212-217
20155626-6	2009	Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK.	3,3',4,5'-tetrahydroxystilbene	38-49	signal transducer and activator of transcription 3	Mus musculus	212-217
19299019-0	2009	STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.	Tyrosine	6-14	signal transducer and activator of transcription 3	Mus musculus	0-5
19299019-3	2009	We show that in response to LPS, the JAK/STAT pathway is activated, leading to tyrosine phosphorylation at residue 705 on STAT3 and at residue 701 on STAT1, respectively.	Tyrosine	79-87	signal transducer and activator of transcription 3	Mus musculus	122-127
19299019-4	2009	A newly developed STAT3 specific inhibitor (stattic) blocked LPS-mediated STAT3 tyrosine phosphorylation and led to inhibition of LPS-mediated IL-1beta and IL-6 production but not TNF-alpha production.	Tyrosine	80-88	signal transducer and activator of transcription 3	Mus musculus	18-23
19299019-4	2009	A newly developed STAT3 specific inhibitor (stattic) blocked LPS-mediated STAT3 tyrosine phosphorylation and led to inhibition of LPS-mediated IL-1beta and IL-6 production but not TNF-alpha production.	Tyrosine	80-88	signal transducer and activator of transcription 3	Mus musculus	74-79
19052144-3	2009	The present study investigated the effect of leptin-induced STAT3 signaling in the DSS and Con A models.	Dextran Sulfate	83-86	signal transducer and activator of transcription 3	Mus musculus	60-65
19052144-10	2009	In conclusion, lack of leptin-induced STAT3 signaling is associated with reduced cytokine production following DSS and Con A administration, but it appears to sensitize mice to the effects of proinflammatory mediators.	Dextran Sulfate	111-114	signal transducer and activator of transcription 3	Mus musculus	38-43
19293145-6	2009	Abeta peptides and nicotine differentially activate several intracellular signaling pathways, including the phosphatidylinositol 3-kinase/v-akt murine thymoma viral oncogene homolog pathway, the extracellular signal-regulated kinase/mitogen-activated protein kinase, and JAK-2/STAT-3 pathways.	Nicotine	19-27	signal transducer and activator of transcription 3	Mus musculus	277-283
19131594-1	2009	Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes.	Tyrosine	39-47	signal transducer and activator of transcription 3	Mus musculus	114-119
19131594-1	2009	Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes.	Serine	52-58	signal transducer and activator of transcription 3	Mus musculus	78-83
19131594-1	2009	Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes.	Serine	52-58	signal transducer and activator of transcription 3	Mus musculus	114-119
19088198-7	2008	These results also provide an additional rationale to therapeutically target NPM/ALK and STAT3 in ALK+TCL.	Triclosan	102-105	signal transducer and activator of transcription 3	Mus musculus	89-94
18820286-6	2008	DDMN inhibited TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription 3.	Tetradecanoylphorbol Acetate	15-18	signal transducer and activator of transcription 3	Mus musculus	76-126
18854310-8	2008	In addition, LAR deficiency enhanced H(2)O(2)-induced phosphorylation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and p38 mitogen-activated protein kinase (MAPK).	Hydrogen Peroxide	37-45	signal transducer and activator of transcription 3	Mus musculus	96-146
18854310-8	2008	In addition, LAR deficiency enhanced H(2)O(2)-induced phosphorylation of Janus kinase 2 (JAK2), signal transducer and activator of transcription 3 (STAT3), and p38 mitogen-activated protein kinase (MAPK).	Hydrogen Peroxide	37-45	signal transducer and activator of transcription 3	Mus musculus	148-153
18854310-10	2008	AG490, a JAK2-specific inhibitor, significantly attenuated H(2)O(2)-induced apoptosis, and blocked H(2)O(2)-induced activation of STAT3, but not p38 MAPK in both wild-type and LAR(-/-) VSMCs.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	130-135
18854310-10	2008	AG490, a JAK2-specific inhibitor, significantly attenuated H(2)O(2)-induced apoptosis, and blocked H(2)O(2)-induced activation of STAT3, but not p38 MAPK in both wild-type and LAR(-/-) VSMCs.	Hydrogen Peroxide	99-107	signal transducer and activator of transcription 3	Mus musculus	130-135
18854310-12	2008	Together, these data indicate that LAR regulates Fyn/JAK2/STAT3 and Fyn/p38 MAPK pathways involved in ROS-induced apoptosis.	Reactive Oxygen Species	102-105	signal transducer and activator of transcription 3	Mus musculus	58-63
19063842-9	2008	Furthermore, resveratrol could reduce the expression of IL-6 mRNA and intracellular content of IL-6, and decrease the expression of p-STAT3 protein in the liver of leukemic mice at a dose-dependent manner.	Resveratrol	13-24	signal transducer and activator of transcription 3	Mus musculus	134-139
19063842-10	2008	CONCLUSION: Resveratrol can function as an antileukemic agent through inducing apoptosis, modulating IL-6 and STAT3 both in vitro and in vivo.	Resveratrol	12-23	signal transducer and activator of transcription 3	Mus musculus	110-115
18985009-0	2008	LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression.	LYR 71	0-5	signal transducer and activator of transcription 3	Mus musculus	80-85
18973601-9	2008	Altogether, these findings point to alteration in brain STAT3 as a key mechanism for the lack of effect of LPS on social interaction in mice fed with the n-6 PUFA diet.	n-6 pufa	154-162	signal transducer and activator of transcription 3	Mus musculus	56-61
19330073-0	2008	Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice.	Pravastatin	0-11	signal transducer and activator of transcription 3	Mus musculus	62-115
19330073-0	2008	Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice.	Pravastatin	0-11	signal transducer and activator of transcription 3	Mus musculus	117-122
19330073-1	2008	The purpose of this study was to determine whether pravastatin"s prevention of aortic atherosclerosis via attenuation of IL-6 action depends on modulation of STAT3 activity.	Pravastatin	51-62	signal transducer and activator of transcription 3	Mus musculus	158-163
19330073-3	2008	After eight weeks, pravastatin significantly prevented atherosclerotic lesion and reduced levels of IL-6 in serum and lesion, and significantly decreased expressions of phosphorylated STAT3 (pSTAT3) and increased suppressor of cytokine signaling 3 (SOCS3) expressions in lesions.	Pravastatin	19-30	signal transducer and activator of transcription 3	Mus musculus	184-189
19330073-4	2008	Our results suggested that pravastatin"s aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity.	Pravastatin	27-38	signal transducer and activator of transcription 3	Mus musculus	151-156
18757549-11	2008	In the liver, treatment with E(2) and PPT increased and decreased the respective expression levels of the transcription factor signal transducer and activator of transcription 3, and of glucose-6-phosphatase.	Estradiol	29-33	signal transducer and activator of transcription 3	Mus musculus	127-177
18757549-11	2008	In the liver, treatment with E(2) and PPT increased and decreased the respective expression levels of the transcription factor signal transducer and activator of transcription 3, and of glucose-6-phosphatase.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	38-41	signal transducer and activator of transcription 3	Mus musculus	127-177
19258740-4	2008	We have now investigated the effects of hepatic overexpression of STAT3, achieved by adenovirus-mediated gene transfer, on glucose and lipid metabolism in insulin-resistant diabetic mice.	Glucose	123-130	signal transducer and activator of transcription 3	Mus musculus	66-71
19258740-5	2008	Forced expression of STAT3 reduced blood glucose and plasma insulin concentrations as well as the hepatic abundance of mRNA for phosphoenolpyruvate carboxykinase.	Glucose	41-48	signal transducer and activator of transcription 3	Mus musculus	21-26
19258740-7	2008	The hepatic abundance of mRNAs for fatty acid synthase and acetyl-CoA carboxylase, both of which catalyze the synthesis of fatty acids, was increased by overexpression of STAT3, whereas that of mRNAs for sterol regulatory element-binding proteins 1a, 1c, or 2 was unaffected.	Fatty Acids	123-134	signal transducer and activator of transcription 3	Mus musculus	171-176
19145512-12	2009	Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression.	epigallocatechin gallate	52-56	signal transducer and activator of transcription 3	Mus musculus	0-5
19145512-12	2009	Stat3 activation was dose-dependently suppressed by EGCG in tumor cells, and an average of 53.5% reduction was observed in tumor tissues, but EGCG treatment did not change total Stat3 expression.	epigallocatechin gallate	142-146	signal transducer and activator of transcription 3	Mus musculus	0-5
19145512-13	2009	CONCLUSION: EGCG reduces expression of VEGF in gastric cancer by inhibiting activation of Stat3, thereby inhibits tumor growth and angiogenesis of gastric cancer.	epigallocatechin gallate	12-16	signal transducer and activator of transcription 3	Mus musculus	90-95
18981115-6	2008	Imatinib significantly reduced the activation of the transcription factors STAT3 and STAT5 in Treg.	Imatinib Mesylate	0-8	signal transducer and activator of transcription 3	Mus musculus	75-80
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	85-88	signal transducer and activator of transcription 3	Mus musculus	32-37
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	96-99	signal transducer and activator of transcription 3	Mus musculus	32-37
18985009-0	2008	LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression.	trimeric	23-31	signal transducer and activator of transcription 3	Mus musculus	80-85
18985009-0	2008	LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression.	Resveratrol	32-43	signal transducer and activator of transcription 3	Mus musculus	80-85
18985009-3	2008	We present herein that 6-methyl-2-propylimino-6, 7-dihydro-5H-benzo [1, 3]-oxathiol- 4-one (LYR71) , a derivative of trimeric resveratrol, has an anticancer activity through inhibition of STAT3 activation.	6-methyl-2-propylimino-6, 7-dihydro-5h-benzo [1, 3]-oxathiol- 4-one	23-90	signal transducer and activator of transcription 3	Mus musculus	188-193
18985009-3	2008	We present herein that 6-methyl-2-propylimino-6, 7-dihydro-5H-benzo [1, 3]-oxathiol- 4-one (LYR71) , a derivative of trimeric resveratrol, has an anticancer activity through inhibition of STAT3 activation.	LYR 71	92-97	signal transducer and activator of transcription 3	Mus musculus	188-193
18985009-3	2008	We present herein that 6-methyl-2-propylimino-6, 7-dihydro-5H-benzo [1, 3]-oxathiol- 4-one (LYR71) , a derivative of trimeric resveratrol, has an anticancer activity through inhibition of STAT3 activation.	trimeric resveratrol	117-137	signal transducer and activator of transcription 3	Mus musculus	188-193
18718531-8	2008	Pharmacological JNK inhibition suppresses leptin-stimulated DNA binding activity, as well as Ser-727 phosphorylation, of STAT3.	Serine	93-96	signal transducer and activator of transcription 3	Mus musculus	121-126
18718531-9	2008	Since JNK upregulates STAT3 activity via Ser-727 phosphorylation, JNK mediates leptin-stimulated STAT3 activation through Ser-727 phosphorylation.	Serine	41-44	signal transducer and activator of transcription 3	Mus musculus	22-27
18718531-9	2008	Since JNK upregulates STAT3 activity via Ser-727 phosphorylation, JNK mediates leptin-stimulated STAT3 activation through Ser-727 phosphorylation.	Serine	41-44	signal transducer and activator of transcription 3	Mus musculus	97-102
18718531-9	2008	Since JNK upregulates STAT3 activity via Ser-727 phosphorylation, JNK mediates leptin-stimulated STAT3 activation through Ser-727 phosphorylation.	Serine	122-125	signal transducer and activator of transcription 3	Mus musculus	22-27
18718531-9	2008	Since JNK upregulates STAT3 activity via Ser-727 phosphorylation, JNK mediates leptin-stimulated STAT3 activation through Ser-727 phosphorylation.	Serine	122-125	signal transducer and activator of transcription 3	Mus musculus	97-102
18723372-0	2008	Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through S6K1-p42/44 MAPK pathway and STAT3 (Ser 727) phosphorylation in Raw 264.7 cells.	Serine	120-123	signal transducer and activator of transcription 3	Mus musculus	113-118
18652890-5	2008	The secretion of IFN-alpha was reduced in IRF2-silenced macrophages, resulting in a disappearance of tyrosine-phosphorylated Stat3 and a reduction of pro-inflammatory responses, despite induction of Mal adapter protein.	Tyrosine	101-109	signal transducer and activator of transcription 3	Mus musculus	125-130
18723372-4	2008	To investigate the signaling mechanism of nicotine induced suppression of NO synthesis and iNOS expression induced by LPS, we focused on the possible roles of p42/44 MAPK, S6K1, and signal transducers and activators of transcription 3 (STAT3) signaling.	Nicotine	42-50	signal transducer and activator of transcription 3	Mus musculus	236-241
18723372-7	2008	Furthermore, we found that LPS-induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine.	Serine	67-73	signal transducer and activator of transcription 3	Mus musculus	58-63
18723372-7	2008	Furthermore, we found that LPS-induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine.	Serine	67-73	signal transducer and activator of transcription 3	Mus musculus	128-133
18723372-7	2008	Furthermore, we found that LPS-induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine.	Nicotine	170-178	signal transducer and activator of transcription 3	Mus musculus	58-63
18723372-7	2008	Furthermore, we found that LPS-induced phosphorylation of STAT3 at serine 727 is mediated by S6K1-p42/44 MAPK pathway, and this STAT3 phosphorylation was also blocked by nicotine.	Nicotine	170-178	signal transducer and activator of transcription 3	Mus musculus	128-133
18723372-9	2008	Taken together, our results suggest that nicotine inhibits LPS-induced NO synthesis through suppression of S6K1-p42/44 MAPK pathway and phosphorylation of STAT3 in Raw 264.7 cells.	Nicotine	41-49	signal transducer and activator of transcription 3	Mus musculus	155-160
18782267-6	2008	Importantly, triptolide inhibited the transcription of interleukin-17 (IL-17) mRNA and IL-6-induced phosphorylation of STAT3, a key signalling molecule involved in the development of Th17 cells.	triptolide	13-23	signal transducer and activator of transcription 3	Mus musculus	119-124
18819004-6	2008	Our results suggest a role of entities downstream of IL6-mediated JAK/STAT3 signaling in development of dexamethasone resistance by 7TD1-Dxm cells.	Dexamethasone	104-117	signal transducer and activator of transcription 3	Mus musculus	70-75
18819004-6	2008	Our results suggest a role of entities downstream of IL6-mediated JAK/STAT3 signaling in development of dexamethasone resistance by 7TD1-Dxm cells.	Dexamethasone	137-140	signal transducer and activator of transcription 3	Mus musculus	70-75
18615483-8	2008	RESULTS: The results demonstrated that (i) T40214 significantly inhibited STAT3 activation and induced apoptosis in both androgen-dependent and androgen-independent PC cells; (ii) T40214 delivered by ployethylenimine (PEI) significantly suppressed prostate tumor growth in tumor-bearing nude mice due to that T40214 inhibited STAT3 activation and then greatly promoted apoptosis, reduced angiogenesis and cell proliferation in prostate tumors.	t40214	43-49	signal transducer and activator of transcription 3	Mus musculus	74-79
18615483-8	2008	RESULTS: The results demonstrated that (i) T40214 significantly inhibited STAT3 activation and induced apoptosis in both androgen-dependent and androgen-independent PC cells; (ii) T40214 delivered by ployethylenimine (PEI) significantly suppressed prostate tumor growth in tumor-bearing nude mice due to that T40214 inhibited STAT3 activation and then greatly promoted apoptosis, reduced angiogenesis and cell proliferation in prostate tumors.	t40214	43-49	signal transducer and activator of transcription 3	Mus musculus	326-331
18562323-7	2008	Rodents injected with NP had a substantial increase in STAT3 tyrosine phosphorylation and ERK 1 and 2 activation.	Tyrosine	61-69	signal transducer and activator of transcription 3	Mus musculus	55-60
18403479-0	2008	Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.	serine727	161-170	signal transducer and activator of transcription 3	Mus musculus	190-240
18392040-0	2008	Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model.	cucurbitacin I	85-92	signal transducer and activator of transcription 3	Mus musculus	62-67
18392040-2	2008	In this study, we tested the hypothesis that the combination of CpG (a DC activator) and JSI-124 (a STAT3 inhibitor) may generate synergistic antitumor effects compared to CpG or JSI-124 alone.	cucurbitacin I	89-96	signal transducer and activator of transcription 3	Mus musculus	100-105
18550525-4	2008	Inhibitors of GSK3 greatly reduced (>75%) the activating STAT3 tyrosine phosphorylation in mouse primary astrocytes, microglia, and macrophage-derived RAW264.7 cells induced by interferon-gamma (IFNgamma), IFNalpha, interleukin-6, or insulin.	Tyrosine	66-74	signal transducer and activator of transcription 3	Mus musculus	60-65
18298650-8	2008	Parthenolide, a STAT3 inhibitor, completely abolished the beneficial effects of G-CSF on cardiac function and remodelling with loss of effect on both anti-cardiomyocyte degeneration and anti-fibrosis.	parthenolide	0-12	signal transducer and activator of transcription 3	Mus musculus	16-21
18718058-0	2008	[Regulatory effect of resveratrol on JAK1/STAT3 signal transduction pathway in leukemia].	Resveratrol	22-33	signal transducer and activator of transcription 3	Mus musculus	42-47
18718058-4	2008	The results indicated that resveratrol could significantly inhibit the JAK1/STAT3 signal transduction pathway, down-regulate expressions of pJAK1 and pSTAT3 and reduce the phosphorylation of JAK1 and STAT3 in a dose-and time-dependent manner.	Resveratrol	27-38	signal transducer and activator of transcription 3	Mus musculus	76-81
18718058-4	2008	The results indicated that resveratrol could significantly inhibit the JAK1/STAT3 signal transduction pathway, down-regulate expressions of pJAK1 and pSTAT3 and reduce the phosphorylation of JAK1 and STAT3 in a dose-and time-dependent manner.	Resveratrol	27-38	signal transducer and activator of transcription 3	Mus musculus	151-156
18718058-5	2008	It is concluded that the resveratrol can regulate signal transduction pathway and reduce the activation of JAK1/STAT3 tyrosine phosphorylation significantly, and therefore resveratrol shows chemotherapeutic potential to leukaemia.	Resveratrol	25-36	signal transducer and activator of transcription 3	Mus musculus	112-117
18718058-5	2008	It is concluded that the resveratrol can regulate signal transduction pathway and reduce the activation of JAK1/STAT3 tyrosine phosphorylation significantly, and therefore resveratrol shows chemotherapeutic potential to leukaemia.	Tyrosine	118-126	signal transducer and activator of transcription 3	Mus musculus	112-117
18628471-8	2008	CDDO-Me inhibited constitutive STAT3 phosphorylation and the degradation of IKBalpha in ER-negative breast cancer cells, whereas 268 blocked IKBalpha degradation and the release of interleukin-6 in RAW264.7 macrophage-like cells, inhibited the ability of endothelial cells to organize into networks, and blocked angiogenesis in vivo.	bardoxolone methyl	0-7	signal transducer and activator of transcription 3	Mus musculus	31-36
18403479-9	2008	We demonstrated that a basal level of phosphorylated-STAT3 on Serine(727) associated with an absence of phosphorylation on Tyrosine(705) is essential for osteoclastogenesis.	Serine	62-68	signal transducer and activator of transcription 3	Mus musculus	53-58
18523255-3	2008	To investigate the poorly understood mechanism of CoPPIX-induced HO-1 activity in more detail, we performed gene expression analysis in murine liver, revealing the up-regulation of STAT3 after CoPPIX treatment.	coppix	50-56	signal transducer and activator of transcription 3	Mus musculus	181-186
18590825-10	2008	NF-kappaB and STAT-3 activation were significantly reduced by glycyrrhizin treatment.	Glycyrrhizic Acid	62-74	signal transducer and activator of transcription 3	Mus musculus	14-20
18590825-11	2008	Taken together, our results indicate that prevention of the activation of NF-kappaB and STAT-3 by glycyrrhizin reduces the development of acute inflammation.	Glycyrrhizic Acid	98-110	signal transducer and activator of transcription 3	Mus musculus	88-94
18523255-3	2008	To investigate the poorly understood mechanism of CoPPIX-induced HO-1 activity in more detail, we performed gene expression analysis in murine liver, revealing the up-regulation of STAT3 after CoPPIX treatment.	coppix	193-199	signal transducer and activator of transcription 3	Mus musculus	181-186
18359888-6	2008	O3 increased tyrosine phosphorylation of STAT-3 and STAT-1.	Tyrosine	13-21	signal transducer and activator of transcription 3	Mus musculus	41-47
18467707-6	2008	Nuclear STAT3 staining was induced in bronchiolar epithelial cells following naphthalene-mediated injury in control (Stat3(flox/flox)) mice.	naphthalene	77-88	signal transducer and activator of transcription 3	Mus musculus	8-13
18451994-8	2008	These studies demonstrate that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation.	Glucose	105-112	signal transducer and activator of transcription 3	Mus musculus	136-141
18489773-7	2008	Brain protein levels of IL-1beta, NADPH oxidase subunit p67phox, and phosphorylated-signal transducer and activator of transcription 3 (STAT3) were higher in COX-2-/- and in celecoxib-treated mice, compared to COX-2+/+ mice.	Celecoxib	174-183	signal transducer and activator of transcription 3	Mus musculus	69-134
18471811-8	2008	Intravitreal injection of NMDA led to peak increases in activated STAT3 and STAT3 at 12 and 24h post insult respectively.	N-Methylaspartate	26-30	signal transducer and activator of transcription 3	Mus musculus	66-71
18471811-8	2008	Intravitreal injection of NMDA led to peak increases in activated STAT3 and STAT3 at 12 and 24h post insult respectively.	N-Methylaspartate	26-30	signal transducer and activator of transcription 3	Mus musculus	76-81
18369093-0	2008	STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury.	Phospholipids	28-40	signal transducer and activator of transcription 3	Mus musculus	0-6
18369093-2	2008	Since signal transducer and activator of transcription-3 (STAT-3) plays an important role in protecting respiratory epithelial cells during injury, we hypothesized that STAT-3 may regulate gene expression in type II cells that mediate surfactant phospholipid synthesis.	Phospholipids	246-258	signal transducer and activator of transcription 3	Mus musculus	6-56
18369093-2	2008	Since signal transducer and activator of transcription-3 (STAT-3) plays an important role in protecting respiratory epithelial cells during injury, we hypothesized that STAT-3 may regulate gene expression in type II cells that mediate surfactant phospholipid synthesis.	Phospholipids	246-258	signal transducer and activator of transcription 3	Mus musculus	58-64
18369093-2	2008	Since signal transducer and activator of transcription-3 (STAT-3) plays an important role in protecting respiratory epithelial cells during injury, we hypothesized that STAT-3 may regulate gene expression in type II cells that mediate surfactant phospholipid synthesis.	Phospholipids	246-258	signal transducer and activator of transcription 3	Mus musculus	169-175
18369093-3	2008	Conditional deletion of Stat-3 in respiratory epithelial cells in the lung of transgenic mice (Stat-3(Delta/Delta) mice) decreased surfactant phospholipid synthesis and secretion.	Phospholipids	142-154	signal transducer and activator of transcription 3	Mus musculus	24-30
18369093-3	2008	Conditional deletion of Stat-3 in respiratory epithelial cells in the lung of transgenic mice (Stat-3(Delta/Delta) mice) decreased surfactant phospholipid synthesis and secretion.	Phospholipids	142-154	signal transducer and activator of transcription 3	Mus musculus	95-101
18369093-4	2008	Deletion of Stat-3 was associated with decreased expression of Akt2, Srebf-1, and other genes expressed in type II cells that may influence surfactant phospholipid synthesis (Glut-1, Slc34a2, Gpam, Acox2, and Cds2).	Phospholipids	151-163	signal transducer and activator of transcription 3	Mus musculus	12-18
18369093-6	2008	Saturated phosphatidylcholine and surfactant protein B levels were significantly decreased in bronchoalveolar lavage fluid from LPS-treated Stat-3(Delta/Delta) mice.	saturated phosphatidylcholine	0-29	signal transducer and activator of transcription 3	Mus musculus	140-146
18500982-3	2008	To further investigate the importance of STAT3 in the establishment of ES cells we have in a first step derived stable pluripotent embryonic stem cells from transgenic FVB mice expressing a conditional tamoxifen dependent STAT3-MER fusion protein.	Tamoxifen	202-211	signal transducer and activator of transcription 3	Mus musculus	222-227
18500982-5	2008	RESULTS: Transgenic STAT3-MER blastocysts yielded pluripotent germline-competent ES cells at a high frequency in the absence of LIF when established in tamoxifen-containing medium.	Tamoxifen	152-161	signal transducer and activator of transcription 3	Mus musculus	20-25
17929248-5	2008	The combined high glucose and ANG II significantly increased the STAT3 phosphorylation compared with high glucose or ANG II alone.	Glucose	18-25	signal transducer and activator of transcription 3	Mus musculus	65-70
17929248-5	2008	The combined high glucose and ANG II significantly increased the STAT3 phosphorylation compared with high glucose or ANG II alone.	Glucose	106-113	signal transducer and activator of transcription 3	Mus musculus	65-70
18431520-5	2008	Furthermore, reducing STAT3 activity in gp130(Y757F/Y757F) mice, either genetically or by therapeutic administration of STAT3 antisense oligonucleotides, normalized gastric IL-11 expression and alleviated gastric tumor burden.	Oligonucleotides	136-152	signal transducer and activator of transcription 3	Mus musculus	22-27
18431520-5	2008	Furthermore, reducing STAT3 activity in gp130(Y757F/Y757F) mice, either genetically or by therapeutic administration of STAT3 antisense oligonucleotides, normalized gastric IL-11 expression and alleviated gastric tumor burden.	Oligonucleotides	136-152	signal transducer and activator of transcription 3	Mus musculus	120-125
18201968-7	2008	We also found that suppression of STAT3, Oct-3/4, or Eed causes induction of differentiation-associated genes as well as loss of Lys(27)-trimethylated histone H3 at the promoter regions of the differentiation-associated genes.	Lysine	129-132	signal transducer and activator of transcription 3	Mus musculus	34-39
18174171-3	2008	LIF signals through a receptor heterodimer of LIF receptor (LIFR) and gp130 and induces the tyrosine phosphorylation of STAT3 leading to target gene expression.	Tyrosine	92-100	signal transducer and activator of transcription 3	Mus musculus	120-125
17962218-5	2007	In addition, 5-OH-HxMF can inhibit TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription-3.	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	96-146
18395094-9	2008	In addition, ethanol feeding elicited an aggravated inflammatory response mediated by Kupffer cells in Nrf2(-/-) mice as shown by an increased tumor necrosis factor-alpha secretion and activation of the interleukin-6/Stat-3 pathway.	Ethanol	13-20	signal transducer and activator of transcription 3	Mus musculus	217-223
18249557-4	2008	We show that AuE strongly down-regulates STAT3 activation induced in the lung by carrageenan with concomitant attenuation of all parameters examined associated with inflammation, suggesting that STAT3 should be a new molecular target for anti-inflammatory treatment.	Carrageenan	81-92	signal transducer and activator of transcription 3	Mus musculus	41-46
17681440-0	2008	Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.	Cucurbitacins	74-87	signal transducer and activator of transcription 3	Mus musculus	58-63
17967780-5	2008	In young mice, iPoco3x10 increased the phosphorylated over total STAT3 (phosphorylated STAT3/STAT3) ratio at 10 minutes of reperfusion in the postconditioned anterior wall compared with the control posterior wall.	ipoco3x10	15-24	signal transducer and activator of transcription 3	Mus musculus	65-70
17967780-5	2008	In young mice, iPoco3x10 increased the phosphorylated over total STAT3 (phosphorylated STAT3/STAT3) ratio at 10 minutes of reperfusion in the postconditioned anterior wall compared with the control posterior wall.	ipoco3x10	15-24	signal transducer and activator of transcription 3	Mus musculus	87-92
17967780-5	2008	In young mice, iPoco3x10 increased the phosphorylated over total STAT3 (phosphorylated STAT3/STAT3) ratio at 10 minutes of reperfusion in the postconditioned anterior wall compared with the control posterior wall.	ipoco3x10	15-24	signal transducer and activator of transcription 3	Mus musculus	87-92
17901129-8	2008	Five of these eight selected genes, Shp, Stat3, Pdgds, Pck1, and Pdk4, all responded to propyl pyrazole triol after 4 h treatment.	4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol	88-109	signal transducer and activator of transcription 3	Mus musculus	41-46
18268048-8	2008	During feeding, both mRNA and protein levels of GSK-3beta decreased in Stat3(f/+) mice, which reflected the need of hepatocytes for insulin to induce glycogen synthesis.	Glycogen	150-158	signal transducer and activator of transcription 3	Mus musculus	71-76
18268048-10	2008	Administration of GSK-3beta inhibitors lithium chloride and L803-mts restored glucose homeostasis and rescued the glucose intolerance and impaired insulin response in L-Stat3(-/-) mice.	Lithium Chloride	39-55	signal transducer and activator of transcription 3	Mus musculus	169-174
18218321-7	2008	To investigate the effect of STAT3, we used AG490, which selectively inhibits the activation of Janus kinase (JAK) family tyrosine kinase and inhibits the constitutive activation of STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	44-49	signal transducer and activator of transcription 3	Mus musculus	29-34
18218321-7	2008	To investigate the effect of STAT3, we used AG490, which selectively inhibits the activation of Janus kinase (JAK) family tyrosine kinase and inhibits the constitutive activation of STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	44-49	signal transducer and activator of transcription 3	Mus musculus	182-187
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	7,12-dimethylbenz[a	82-101	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	anthracene	102-112	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	9,10-Dimethyl-1,2-benzanthracene	114-118	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	169-205	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-3	2008	Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	207-210	signal transducer and activator of transcription 3	Mus musculus	22-28
17700521-4	2008	In two-stage chemical carcinogenesis experiments using DMBA as the tumor initiator and TPA as the promoter, K5.Stat3C mice developed skin tumors with a shorter latency and in much greater number compared to non-transgenic littermates.	Tetradecanoylphorbol Acetate	87-90	signal transducer and activator of transcription 3	Mus musculus	111-117
17681440-6	2008	The anti-cancer and STAT3 inhibitory activity of polymeric micellar cucurbitacins were comparable with free drugs in B16.F10 melanoma cell line in vitro.	Cucurbitacins	68-81	signal transducer and activator of transcription 3	Mus musculus	20-25
17962218-5	2007	In addition, 5-OH-HxMF can inhibit TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription-3.	Tetradecanoylphorbol Acetate	35-38	signal transducer and activator of transcription 3	Mus musculus	96-146
18025205-6	2007	We demonstrated that CD28 activation in CD4(+)CD25(-) T lymphocytes leads to STAT3 Tyr(705) phosphorylation in an Lck-dependent manner.	Tyrosine	83-86	signal transducer and activator of transcription 3	Mus musculus	77-82
18025205-7	2007	STAT3 neutralization during naive peripheral CD4(+)CD25(-) T cell conversion into Treg through costimulation with TCR/CD28 and TGF-beta1, decreased FOXP3 expression, prevented the acquisition of suppressive functions and restored the ability of the converted lymphocytes to produce IL-2 and IFN-gamma.	treg	82-86	signal transducer and activator of transcription 3	Mus musculus	0-5
17348027-4	2007	At a concentration of 20 microM, EGCG decreased the migratory potential of bladder carcinoma cells with concomitant activation of p42/44 MAPK and STAT3 and inactivation of Akt.	epigallocatechin gallate	33-37	signal transducer and activator of transcription 3	Mus musculus	146-151
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Norepinephrine	52-66	signal transducer and activator of transcription 3	Mus musculus	105-155
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Norepinephrine	52-66	signal transducer and activator of transcription 3	Mus musculus	157-162
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Epinephrine	55-66	signal transducer and activator of transcription 3	Mus musculus	105-155
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Epinephrine	55-66	signal transducer and activator of transcription 3	Mus musculus	157-162
17974982-3	2007	Exposure of ovarian cancer cell lines to increasing concentrations of norepinephrine or epinephrine showed that both independently increased levels of phosphorylated STAT3 in a dose-dependent fashion.	Norepinephrine	70-84	signal transducer and activator of transcription 3	Mus musculus	166-171
17974982-3	2007	Exposure of ovarian cancer cell lines to increasing concentrations of norepinephrine or epinephrine showed that both independently increased levels of phosphorylated STAT3 in a dose-dependent fashion.	Epinephrine	73-84	signal transducer and activator of transcription 3	Mus musculus	166-171
17974982-4	2007	Immunolocalization and ELISA of nuclear extracts confirmed increased nuclear STAT3 in response to norepinephrine.	Norepinephrine	98-112	signal transducer and activator of transcription 3	Mus musculus	77-82
17974982-5	2007	Activation of STAT3 was inhibited by blockade of the beta1- and beta2-adrenergic receptors with propranolol, and by blocking protein kinase A with KT5720, but not with the alpha receptor blockers prazosin (alpha1) and/or yohimbine (alpha2).	Propranolol	96-107	signal transducer and activator of transcription 3	Mus musculus	14-19
17974982-5	2007	Activation of STAT3 was inhibited by blockade of the beta1- and beta2-adrenergic receptors with propranolol, and by blocking protein kinase A with KT5720, but not with the alpha receptor blockers prazosin (alpha1) and/or yohimbine (alpha2).	KT 5720	147-153	signal transducer and activator of transcription 3	Mus musculus	14-19
17974982-5	2007	Activation of STAT3 was inhibited by blockade of the beta1- and beta2-adrenergic receptors with propranolol, and by blocking protein kinase A with KT5720, but not with the alpha receptor blockers prazosin (alpha1) and/or yohimbine (alpha2).	Yohimbine	221-230	signal transducer and activator of transcription 3	Mus musculus	14-19
17974982-6	2007	Catecholamine-mediated STAT3 activation was not inhibited by pretreatment with an anti-interleukin 6 (IL-6) antibody or with small interfering RNA (siRNA)-mediated decrease in IL-6 or gp130.	Catecholamines	0-13	signal transducer and activator of transcription 3	Mus musculus	23-28
17974982-7	2007	Regarding the effects of STAT3 activation, exposure to norepinephrine resulted in an increase in invasion and matrix metalloproteinase (MMP-2 and MMP-9) production.	Norepinephrine	55-69	signal transducer and activator of transcription 3	Mus musculus	25-30
17974982-9	2007	In mice, treatment with liposome-incorporated siRNA directed against STAT3 significantly reduced isoproterenol-stimulated tumor growth.	Isoproterenol	97-110	signal transducer and activator of transcription 3	Mus musculus	69-74
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Norepinephrine	59-73	signal transducer and activator of transcription 3	Mus musculus	50-55
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Norepinephrine	59-73	signal transducer and activator of transcription 3	Mus musculus	316-321
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Epinephrine	62-73	signal transducer and activator of transcription 3	Mus musculus	50-55
17683579-4	2007	METHODS: A STAT3 decoy ODN was transfected into A549 lung cancer cell line in vitro by using lipofectamine.	Lipofectamine	93-106	signal transducer and activator of transcription 3	Mus musculus	11-16
17583567-7	2007	PKCepsilon overexpression increases Stat3 activation after either TPA treatment or UVR exposure.	Tetradecanoylphorbol Acetate	66-69	signal transducer and activator of transcription 3	Mus musculus	36-41
17583567-15	2007	As observed in vitro with immunocomplex kinase assay with immunopurified PKCepsilon and Stat3, PKCepsilon phosphorylated Stat3 at the serine 727 residue.	Serine	134-140	signal transducer and activator of transcription 3	Mus musculus	121-126
17606840-5	2007	In wild-type mice, ischemic PC induced membranous translocation of protein kinase C (PKC) epsilon and an increase in pSer-MEK-1/2 and pTyr-p44/42 mitogen-activated protein kinase, nuclear pSer-signal transducers and activators of transcription (STAT)1 and pSer-STAT3, and nuclear STAT1/3 DNA binding activity, followed by upregulation of cyclooxygenase-2 protein and activity 24 hours later.	pc	28-30	signal transducer and activator of transcription 3	Mus musculus	261-266
18210874-0	2007	[Inhibitory effect of silencing STAT3 gene with short hairpin RNA mediated by polyamidoamine dendrimers on growth of prostate cancer].	Poly(amidoamine)	78-92	signal transducer and activator of transcription 3	Mus musculus	32-37
18210874-9	2007	MTT results showed that proliferation of prostate cancer cells was suppressed by G5-PAMAM-D/pSilencing 4.1-STAT3-shRNA and induced apoptosis of PC-3 cells in vitro.	monooxyethylene trimethylolpropane tristearate	0-3	signal transducer and activator of transcription 3	Mus musculus	107-112
17549413-0	2007	Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides.	g-quartet oligonucleotides	93-119	signal transducer and activator of transcription 3	Mus musculus	14-19
17089128-0	2007	Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis.	Oligonucleotides	31-46	signal transducer and activator of transcription 3	Mus musculus	12-17
17089128-0	2007	Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis.	Trinitrobenzenesulfonic Acid	50-54	signal transducer and activator of transcription 3	Mus musculus	12-17
17089128-3	2007	This study was executed to investigate the role of STAT3 protein on the pathogenesis of trinitrobenzene sulfonic acid (TNBS)-induced colitis, the pathogenesis of which is CD-like.	Trinitrobenzenesulfonic Acid	88-117	signal transducer and activator of transcription 3	Mus musculus	51-56
17089128-3	2007	This study was executed to investigate the role of STAT3 protein on the pathogenesis of trinitrobenzene sulfonic acid (TNBS)-induced colitis, the pathogenesis of which is CD-like.	Trinitrobenzenesulfonic Acid	119-123	signal transducer and activator of transcription 3	Mus musculus	51-56
17089128-4	2007	METHODS: TNBS-induced colitis was produced, and STAT3 antisense oligonucleotide was administrated intracolonically during the early phase of colitis.	Oligonucleotides	64-79	signal transducer and activator of transcription 3	Mus musculus	48-53
17089128-8	2007	RESULTS: Administration of STAT3 antisense oligonucleotide effectively inhibited STAT3 expression and phosphorylation in inflamed colonic mucosa of colitis.	Oligonucleotides	43-58	signal transducer and activator of transcription 3	Mus musculus	27-32
17089128-8	2007	RESULTS: Administration of STAT3 antisense oligonucleotide effectively inhibited STAT3 expression and phosphorylation in inflamed colonic mucosa of colitis.	Oligonucleotides	43-58	signal transducer and activator of transcription 3	Mus musculus	81-86
17089128-9	2007	The mice that were administered STAT3 antisense oligonucleotide showed less colonic tissue damage with decreased production of inflammatory cytokines such as TNF-alpha and INF-gamma in mucosa compared with that of those TNBS-induced colitis.	Oligonucleotides	48-63	signal transducer and activator of transcription 3	Mus musculus	32-37
17089128-9	2007	The mice that were administered STAT3 antisense oligonucleotide showed less colonic tissue damage with decreased production of inflammatory cytokines such as TNF-alpha and INF-gamma in mucosa compared with that of those TNBS-induced colitis.	Trinitrobenzenesulfonic Acid	220-224	signal transducer and activator of transcription 3	Mus musculus	32-37
17089128-10	2007	Administration of STAT3 antisense oligonucleotide successfully induced apoptosis of LPMCs and counteracted the unbalanced expressions of Bcl-2 and Bax in LPMCs from colitis.	Oligonucleotides	34-49	signal transducer and activator of transcription 3	Mus musculus	18-23
17089128-10	2007	Administration of STAT3 antisense oligonucleotide successfully induced apoptosis of LPMCs and counteracted the unbalanced expressions of Bcl-2 and Bax in LPMCs from colitis.	lpmcs	84-89	signal transducer and activator of transcription 3	Mus musculus	18-23
17089128-10	2007	Administration of STAT3 antisense oligonucleotide successfully induced apoptosis of LPMCs and counteracted the unbalanced expressions of Bcl-2 and Bax in LPMCs from colitis.	lpmcs	154-159	signal transducer and activator of transcription 3	Mus musculus	18-23
17173066-4	2007	Using these cells in vitro, we demonstrate that the tyrosine kinase inhibitor SU5416 (Semaxinib) induces growth arrest and apoptosis independent of the mutation type by inhibiting the functions of Kit, including Kit autophosphorylation and activation of Akt, Erk1/Erk2 and Stat3 downstream signaling pathways.	Semaxinib	78-84	signal transducer and activator of transcription 3	Mus musculus	273-278
17448895-7	2007	Significant inhibition of STAT3 & CREB were also observed along with the inhibition of HO-1 mRNA.	Adenosine Monophosphate	33-36	signal transducer and activator of transcription 3	Mus musculus	26-31
17475846-6	2007	Importantly, the e-STAT3-/- mice had a significant decrease in airway hyperresponsiveness to methacholine.	Methacholine Chloride	93-105	signal transducer and activator of transcription 3	Mus musculus	19-24
17234744-4	2007	Accordingly, methylprednisolone inhibited Tyr phosphorylation of STAT1, STAT3, and STAT5 in IL-2-cultured NK cells but only marginally in IL-15-cultured NK cells, whereas JAK3 was inhibited under both conditions.	Methylprednisolone	13-31	signal transducer and activator of transcription 3	Mus musculus	72-77
17234744-4	2007	Accordingly, methylprednisolone inhibited Tyr phosphorylation of STAT1, STAT3, and STAT5 in IL-2-cultured NK cells but only marginally in IL-15-cultured NK cells, whereas JAK3 was inhibited under both conditions.	Tyrosine	42-45	signal transducer and activator of transcription 3	Mus musculus	72-77
17483332-0	2007	The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.	triterpenoid c-28 methyl ester	10-40	signal transducer and activator of transcription 3	Mus musculus	161-166
17483332-0	2007	The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.	2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid	44-89	signal transducer and activator of transcription 3	Mus musculus	161-166
17483332-7	2007	In vitro, after treatment of 4T1 cells with 500 nmol/L CDDO-Me for 2 h, we found (a) inactivation of STAT3, (b) inactivation of Src and Akt, (c) 4-fold reduction of c-Myc mRNA levels, (d) accumulation of cells in G(2)-M cell cycle phase, (e) abrogation of invasive growth of 4T1 cells, and (f) lack of apoptosis induction.	bardoxolone methyl	55-62	signal transducer and activator of transcription 3	Mus musculus	101-106
17483332-10	2007	In summary, these data suggest that CDDO-Me may have therapeutic potential in breast cancer therapy, in part, through inactivation of STAT3.	bardoxolone methyl	36-43	signal transducer and activator of transcription 3	Mus musculus	134-139
18034310-0	2007	Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3.	g-quartet oligonucleotide	36-61	signal transducer and activator of transcription 3	Mus musculus	91-96
18034310-0	2007	Computational study on mechanism of G-quartet oligonucleotide T40214 selectively targeting Stat3.	t40214	62-68	signal transducer and activator of transcription 3	Mus musculus	91-96
18034310-2	2007	Recently, we developed a G-quartet oligonucleotide T40214 as a novel and potent Stat3 inhibitor.	g-quartet oligonucleotide	25-50	signal transducer and activator of transcription 3	Mus musculus	80-85
18034310-2	2007	Recently, we developed a G-quartet oligonucleotide T40214 as a novel and potent Stat3 inhibitor.	t40214	51-57	signal transducer and activator of transcription 3	Mus musculus	80-85
18034310-3	2007	T40214 specifically inhibited DNA-binding activity of Stat3 and significantly suppressed the growth of many tumor xenografts in nude mice.	t40214	0-6	signal transducer and activator of transcription 3	Mus musculus	54-59
18034310-5	2007	The binding site of T40214 within Stat3 dimer was determined by statistical docking analysis.	t40214	20-26	signal transducer and activator of transcription 3	Mus musculus	34-39
18034310-6	2007	The results indicated that T40214 strongly interacted within the region from residue E638 through E652 of Stat3 dimer.	t40214	27-33	signal transducer and activator of transcription 3	Mus musculus	106-111
18034310-7	2007	The binding model refined by Hex docking disclosed that T40214 binds to SH2 domain of Stat3 and forms H-bonds with residues Q643, Q644, N646, and N647, which are critical for the binding interaction.	t40214	56-62	signal transducer and activator of transcription 3	Mus musculus	86-91
18034310-8	2007	The 3D models also suggested that T40214 inhibits Stat3 activity through disrupting the binding interaction between Stat3 dimer and DNA duplex for transcription.	t40214	34-40	signal transducer and activator of transcription 3	Mus musculus	50-55
18034310-8	2007	The 3D models also suggested that T40214 inhibits Stat3 activity through disrupting the binding interaction between Stat3 dimer and DNA duplex for transcription.	t40214	34-40	signal transducer and activator of transcription 3	Mus musculus	116-121
17660847-7	2007	In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl(4)), hepatocyte DNA synthesis in the CCl(4)-treated L-Stat3(-/-) mice also decreased as compared with Stat3(f/+) mice at 40 h after injection but not at other time points.	Carbon Tetrachloride	76-96	signal transducer and activator of transcription 3	Mus musculus	156-161
17660847-7	2007	In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl(4)), hepatocyte DNA synthesis in the CCl(4)-treated L-Stat3(-/-) mice also decreased as compared with Stat3(f/+) mice at 40 h after injection but not at other time points.	Carbon Tetrachloride	76-96	signal transducer and activator of transcription 3	Mus musculus	204-209
17660847-7	2007	In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl(4)), hepatocyte DNA synthesis in the CCl(4)-treated L-Stat3(-/-) mice also decreased as compared with Stat3(f/+) mice at 40 h after injection but not at other time points.	Cefaclor	139-142	signal transducer and activator of transcription 3	Mus musculus	156-161
17660847-7	2007	In another model of liver regeneration induced by subcutaneous injection of carbon tetrachloride (CCl(4)), hepatocyte DNA synthesis in the CCl(4)-treated L-Stat3(-/-) mice also decreased as compared with Stat3(f/+) mice at 40 h after injection but not at other time points.	Cefaclor	139-142	signal transducer and activator of transcription 3	Mus musculus	204-209
17660847-8	2007	In addition, infiltration of neutrophils and monocyte increased in the liver of CCl(4)-treated L-Stat3(-/-) mice compared to wild-type mice.	Cefaclor	80-83	signal transducer and activator of transcription 3	Mus musculus	97-102
18161298-14	2007	SP method was used to detect the expression of Phospho-Stat3 (Tyr705) and bcl-2.	TFF2 protein, human	0-2	signal transducer and activator of transcription 3	Mus musculus	55-60
17524392-3	2007	ATP also activates IL-6 production and phosphorylation of Stat3 that promotes neuron survival.	Adenosine Triphosphate	0-3	signal transducer and activator of transcription 3	Mus musculus	58-63
17493959-3	2007	We reported that IL-6 transduces two signaling pathways via tyrosine redidues of the signal transducer gp130: one depends on signal transducers and activators of transcription (STAT)-3 activation and the other on Src homology region 2 domain-containing phosphatase 2 (SHP2)/Grb2 associated binder (Gab)/mitogen-activated protein kinase (MAPK) activation.	Tyrosine	60-68	signal transducer and activator of transcription 3	Mus musculus	177-181
17493959-3	2007	We reported that IL-6 transduces two signaling pathways via tyrosine redidues of the signal transducer gp130: one depends on signal transducers and activators of transcription (STAT)-3 activation and the other on Src homology region 2 domain-containing phosphatase 2 (SHP2)/Grb2 associated binder (Gab)/mitogen-activated protein kinase (MAPK) activation.	gab	298-301	signal transducer and activator of transcription 3	Mus musculus	177-181
17683579-12	2007	STAT3-decoy ODN significantly induced apoptosis and reduced [3H]-thymidine incorporation of A549 cells as well as down-regulated STAT3-target genes in vitro.	Tritium	61-63	signal transducer and activator of transcription 3	Mus musculus	0-5
17683579-12	2007	STAT3-decoy ODN significantly induced apoptosis and reduced [3H]-thymidine incorporation of A549 cells as well as down-regulated STAT3-target genes in vitro.	Thymidine	65-74	signal transducer and activator of transcription 3	Mus musculus	0-5
17204554-2	2007	Signal transducer and activator of transcription 3 (STAT3), a mitogenic signaling protein, is activated through tyrosine phosphorylation during the proliferative phases of adipogenesis.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	0-50
17498489-13	2007	The expressions of phospho-Stat3 (Tyr705) and bcl-2 proteins were detected by using SP method.	TFF2 protein, human	84-86	signal transducer and activator of transcription 3	Mus musculus	27-32
17204554-2	2007	Signal transducer and activator of transcription 3 (STAT3), a mitogenic signaling protein, is activated through tyrosine phosphorylation during the proliferative phases of adipogenesis.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	52-57
17204554-4	2007	Here we determined that the adipocyte differentiation cocktail containing isobutylmethylxanthine, dexamethasone, and insulin (MDI) induced STAT3 tyrosine phosphorylation indirectly through the synthesis of an autocrine/paracrine factor.	1-Methyl-3-isobutylxanthine	74-96	signal transducer and activator of transcription 3	Mus musculus	139-144
17204554-4	2007	Here we determined that the adipocyte differentiation cocktail containing isobutylmethylxanthine, dexamethasone, and insulin (MDI) induced STAT3 tyrosine phosphorylation indirectly through the synthesis of an autocrine/paracrine factor.	Dexamethasone	98-111	signal transducer and activator of transcription 3	Mus musculus	139-144
17204554-4	2007	Here we determined that the adipocyte differentiation cocktail containing isobutylmethylxanthine, dexamethasone, and insulin (MDI) induced STAT3 tyrosine phosphorylation indirectly through the synthesis of an autocrine/paracrine factor.	Tyrosine	145-153	signal transducer and activator of transcription 3	Mus musculus	139-144
17204554-6	2007	Recombinant midkine induced STAT3 tyrosine phosphorylation in a time- and dose-dependent manner and stimulated the proliferation of postconfluent 3T3-L1 cells.	Tyrosine	34-42	signal transducer and activator of transcription 3	Mus musculus	28-33
17409458-10	2007	Further analysis showed that silibinin inhibited UVB-caused phosphorylation and nuclear translocation of STAT3 and p65, as well as nuclear factor kappaB (NF-kappaB) DNA binding activity.	Silybin	29-38	signal transducer and activator of transcription 3	Mus musculus	105-110
17409458-11	2007	Together, these results suggest that silibinin causes a strong protective effect against photocarcinogenesis via down-regulation of inflammatory and angiogenic responses, involving HIF-1alpha, STAT3, and NF-kappaB transcription factors, as well as COX2 and iNOS.	Silybin	37-46	signal transducer and activator of transcription 3	Mus musculus	193-198
17173066-4	2007	Using these cells in vitro, we demonstrate that the tyrosine kinase inhibitor SU5416 (Semaxinib) induces growth arrest and apoptosis independent of the mutation type by inhibiting the functions of Kit, including Kit autophosphorylation and activation of Akt, Erk1/Erk2 and Stat3 downstream signaling pathways.	Semaxinib	86-95	signal transducer and activator of transcription 3	Mus musculus	273-278
17204554-7	2007	Midkine neutralizing antibodies inhibited differentiation-induced STAT3 tyrosine phosphorylation as well as adipogenesis.	Tyrosine	72-80	signal transducer and activator of transcription 3	Mus musculus	66-71
16822720-6	2006	Treatment of aortic constricted mice with tyrphostin AG490 failed to develop hypertrophy and showed a marked reduction in phosphorylation of Jak2 and STAT3.	Tyrphostins	42-52	signal transducer and activator of transcription 3	Mus musculus	150-155
17327450-9	2007	Conversely, pioglitazone increased adiponectin secretion and STAT3 phosphorylation in fat tissue of db/db mice and in 3T3-L1 adipocytes.	Pioglitazone	12-24	signal transducer and activator of transcription 3	Mus musculus	61-66
17327450-10	2007	These results suggest that pioglitazone exerts its effect to improve whole-body insulin sensitivity in part through the suppression of SOCS3, which is associated with the increase in STAT3 phosphorylation and adiponectin production in fat tissue.	Pioglitazone	27-39	signal transducer and activator of transcription 3	Mus musculus	183-188
17401459-4	2007	In vitro studies confirmed the selective antiproliferative and proapoptotic effects of sulindac, which also downregulated Stat3 and survivin protein expression.	Sulindac	87-95	signal transducer and activator of transcription 3	Mus musculus	122-127
17401459-5	2007	Stat3 or survivin forced expression partially rescued the antiproliferative effects of sulindac.	Sulindac	87-95	signal transducer and activator of transcription 3	Mus musculus	0-5
17401459-7	2007	Additionally, tumor specimens treated with sulindac showed downregulation of phosphorylated tyrosine-705 Stat3 and survivin expression.	Sulindac	43-51	signal transducer and activator of transcription 3	Mus musculus	105-110
17401459-7	2007	Additionally, tumor specimens treated with sulindac showed downregulation of phosphorylated tyrosine-705 Stat3 and survivin expression.	Tyrosine	92-100	signal transducer and activator of transcription 3	Mus musculus	105-110
17401459-8	2007	Taken together, our data suggest, for the first time, a specific inhibitory effect of sulindac on tumor growth and survivin expression in laryngeal cancer, both in vitro and in vivo, in a Stat3-dependent manner, suggesting a novel therapeutic approach to head and neck cancer.	Sulindac	86-94	signal transducer and activator of transcription 3	Mus musculus	188-193
17295835-9	2007	STAT3 was hyperactivated and acute-phase proteins were elevated in L-SOCS3 cKO mice liver, which were reduced by sodium salicylate treatment.	Sodium Salicylate	113-130	signal transducer and activator of transcription 3	Mus musculus	0-5
17339457-4	2007	Using microarray gene expression profiling of liver RNA samples derived from IRF-2(+/+) and IRF-2(-/-) mice treated with saline or LPS, we identified >40 genes that were significantly down-regulated in IRF-2(-/-) mice, including Stat3, which has been reported to regulate apoptosis.	Sodium Chloride	121-127	signal transducer and activator of transcription 3	Mus musculus	232-237
17209045-6	2007	To investigate the biological significance of Ras/ERK1/2-induced STAT3 Ser(727) phosphorylation for cell proliferation and transformation, N-Ras-transformed NIH-3T3 cells were employed.	Serine	71-74	signal transducer and activator of transcription 3	Mus musculus	65-70
17326158-11	2007	CONCLUSION: CT-1-/- mice are highly sensitive to Fas-mediated apoptosis due in part to deficient STAT-3 activation and inadequate control of calpain activity during the apoptotic process.	ammonium ferrous sulfate	49-52	signal transducer and activator of transcription 3	Mus musculus	97-103
17990952-6	2007	Therefore, we hypothesized that Hcy activates AT1 receptor that potentiates STAT3 via ERK-1/2 phosphorylation.	Homocysteine	32-35	signal transducer and activator of transcription 3	Mus musculus	76-81
17990952-10	2007	The activation of ERK-1/2 and STAT3 were determined by measuring ERK-1/2 phosphorylation and phosphoserine (727) STAT3.	Phosphoserine	93-106	signal transducer and activator of transcription 3	Mus musculus	30-35
17990952-11	2007	RESULTS: Although Hcy dose-dependently induced AT1 receptor expression in the endothelial cells, a significant induction was observed at 100 microM at 48 h. We investigated Hcy-induced ERK-1/2 and STAT3 phosphorylation through AT1 receptor induction, and our results suggest that Hcy activated AT1 receptor which led to ERK-1/2 and STAT3 phosphorylation.	Homocysteine	173-176	signal transducer and activator of transcription 3	Mus musculus	197-202
17990952-11	2007	RESULTS: Although Hcy dose-dependently induced AT1 receptor expression in the endothelial cells, a significant induction was observed at 100 microM at 48 h. We investigated Hcy-induced ERK-1/2 and STAT3 phosphorylation through AT1 receptor induction, and our results suggest that Hcy activated AT1 receptor which led to ERK-1/2 and STAT3 phosphorylation.	Homocysteine	173-176	signal transducer and activator of transcription 3	Mus musculus	332-337
17990952-12	2007	In addition, findings of this study suggest that Hcy-mediated STAT3 activation regulated MMP-9 and collagen type-1.	Homocysteine	49-52	signal transducer and activator of transcription 3	Mus musculus	62-67
17064687-2	2007	Our previous studies revealed that STAT3, a gp130 downstream transcription factor, is required for AGM hematopoiesis and that homeodomain-interacting protein kinase 2 (HIPK2) phosphorylates serine-727 of STAT3.	Serine	190-196	signal transducer and activator of transcription 3	Mus musculus	204-209
17976305-4	2007	Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway.	Tretinoin	73-86	signal transducer and activator of transcription 3	Mus musculus	131-136
17976305-6	2007	These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway.	Tretinoin	134-147	signal transducer and activator of transcription 3	Mus musculus	172-177
17145839-8	2006	HCC tumor volume and weight were reduced and the survival time of mice bearing orthotopically xenografted HCC was approximately doubled in STAT3 ASO-treated mice (P < 0.05).	Oligonucleotides, Antisense	145-148	signal transducer and activator of transcription 3	Mus musculus	139-144
17026715-8	2006	STAT3 translocation was attenuated by UO126.	U 0126	38-43	signal transducer and activator of transcription 3	Mus musculus	0-5
16982690-8	2006	Consistent with the role of Tyk2 in the regulation of tyrosine phosphorylation of Stat3, expression of a constitutively active Stat3 can restore the mitochondrial respiration in Tyk2-null cells treated with IFN-beta.	Tyrosine	54-62	signal transducer and activator of transcription 3	Mus musculus	82-87
16982690-8	2006	Consistent with the role of Tyk2 in the regulation of tyrosine phosphorylation of Stat3, expression of a constitutively active Stat3 can restore the mitochondrial respiration in Tyk2-null cells treated with IFN-beta.	Tyrosine	54-62	signal transducer and activator of transcription 3	Mus musculus	127-132
16377083-2	2006	Signaling through Stat3 is determined by a key phosphorylation at tyr-705.	Tyrosine	66-69	signal transducer and activator of transcription 3	Mus musculus	18-23
16377083-7	2006	Treatment with two platinum compounds which bind the Stat3 protein and inhibit its activity without affecting its phosphorylation directly.	Platinum	19-27	signal transducer and activator of transcription 3	Mus musculus	53-58
16971418-8	2006	However, HO-1 and its reaction product carbon monoxide (CO) lose their protective effects in the presence of STAT3 siRNA in MLEC or in endothelial-specific, STAT3-deficient mice.	Carbon Monoxide	39-54	signal transducer and activator of transcription 3	Mus musculus	109-114
16705451-7	2006	JAK2, upstream of STAT3, was inhibited by AG490 (2 microM).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	42-47	signal transducer and activator of transcription 3	Mus musculus	18-23
16705451-9	2006	STAT3 signaling was activated during hyperdistention of intact bladder and by stretch and mitogenic treatments of BSMC in vitro.	bsmc	114-118	signal transducer and activator of transcription 3	Mus musculus	0-5
16705451-10	2006	JAK2/STAT3 inhibition by AG490 blocked mitogen- and stretch-induced BSMC proliferation.	bsmc	68-72	signal transducer and activator of transcription 3	Mus musculus	5-10
16705451-11	2006	Thus, BSMC stretch responses may involve the recruitment of both growth factor and mechanically induced BSMC growth responses integrated by a common signaling pathway, STAT3.	bsmc	6-10	signal transducer and activator of transcription 3	Mus musculus	168-173
16705451-11	2006	Thus, BSMC stretch responses may involve the recruitment of both growth factor and mechanically induced BSMC growth responses integrated by a common signaling pathway, STAT3.	bsmc	104-108	signal transducer and activator of transcription 3	Mus musculus	168-173
16959849-10	2006	Although there was no effect of IL-1beta on the phosphorylation of ELK, Janus kinase 2, or signal transducers and activators of transcription (STAT) 1, IL-1beta significantly increased tyrosine-phosphorylation of STAT3, an effect attenuated by PD98059.	Tyrosine	185-193	signal transducer and activator of transcription 3	Mus musculus	213-218
17006946-8	2006	This indomethacin-induced injury was associated with activation of IL-6-STAT3 signaling, increased expression of alpha(1)-AT mRNA, and greater accumulation of mutant polymerized alpha(1)-ATZ protein in livers of indomethacin-treated PiZ mice compared to vehicle-treated PiZ animals.	Indomethacin	5-17	signal transducer and activator of transcription 3	Mus musculus	72-77
16860915-0	2006	Low-level bisphenol A increases production of glial fibrillary acidic protein in differentiating astrocyte progenitor cells through excessive STAT3 and Smad1 activation.	bisphenol A	10-21	signal transducer and activator of transcription 3	Mus musculus	142-147
16971418-8	2006	However, HO-1 and its reaction product carbon monoxide (CO) lose their protective effects in the presence of STAT3 siRNA in MLEC or in endothelial-specific, STAT3-deficient mice.	Carbon Monoxide	39-54	signal transducer and activator of transcription 3	Mus musculus	157-162
16971418-8	2006	However, HO-1 and its reaction product carbon monoxide (CO) lose their protective effects in the presence of STAT3 siRNA in MLEC or in endothelial-specific, STAT3-deficient mice.	Carbon Monoxide	56-58	signal transducer and activator of transcription 3	Mus musculus	109-114
16971418-8	2006	However, HO-1 and its reaction product carbon monoxide (CO) lose their protective effects in the presence of STAT3 siRNA in MLEC or in endothelial-specific, STAT3-deficient mice.	Carbon Monoxide	56-58	signal transducer and activator of transcription 3	Mus musculus	157-162
16918381-5	2006	Moreover, analogous to VEGF, morphine stimulates oncogenic signal transducer and activator of transcription 3 (STAT3) signaling.	Morphine	29-37	signal transducer and activator of transcription 3	Mus musculus	59-109
16918381-5	2006	Moreover, analogous to VEGF, morphine stimulates oncogenic signal transducer and activator of transcription 3 (STAT3) signaling.	Morphine	29-37	signal transducer and activator of transcription 3	Mus musculus	111-116
16737695-7	2006	Immunoprecipitation and Western blot analyses showed that LIF induces tyrosine phosphorylation of JAK1, TYK2 and STAT3 in 30 min and treatment with 15d-PGJ2 or ATRA results in a dose-dependent decrease in LIF-induced phosphorylation of JAK1 and STAT3 in D3-ES cells.	Tyrosine	70-78	signal transducer and activator of transcription 3	Mus musculus	113-118
16737695-7	2006	Immunoprecipitation and Western blot analyses showed that LIF induces tyrosine phosphorylation of JAK1, TYK2 and STAT3 in 30 min and treatment with 15d-PGJ2 or ATRA results in a dose-dependent decrease in LIF-induced phosphorylation of JAK1 and STAT3 in D3-ES cells.	Tyrosine	70-78	signal transducer and activator of transcription 3	Mus musculus	245-250
16737695-7	2006	Immunoprecipitation and Western blot analyses showed that LIF induces tyrosine phosphorylation of JAK1, TYK2 and STAT3 in 30 min and treatment with 15d-PGJ2 or ATRA results in a dose-dependent decrease in LIF-induced phosphorylation of JAK1 and STAT3 in D3-ES cells.	15-deoxy-delta(12,14)-prostaglandin J2	148-156	signal transducer and activator of transcription 3	Mus musculus	113-118
16737695-7	2006	Immunoprecipitation and Western blot analyses showed that LIF induces tyrosine phosphorylation of JAK1, TYK2 and STAT3 in 30 min and treatment with 15d-PGJ2 or ATRA results in a dose-dependent decrease in LIF-induced phosphorylation of JAK1 and STAT3 in D3-ES cells.	15-deoxy-delta(12,14)-prostaglandin J2	148-156	signal transducer and activator of transcription 3	Mus musculus	245-250
16788692-4	2006	Tyrosine phosphorylation of the EGFR and STAT3 was studied in hydrogen peroxide (H(2)O(2))-treated mouse proximal tubule (TKPTS) cells or in mouse kidney after ischemia/reperfusion (I/R) injury by Western blotting.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	41-46
16788692-4	2006	Tyrosine phosphorylation of the EGFR and STAT3 was studied in hydrogen peroxide (H(2)O(2))-treated mouse proximal tubule (TKPTS) cells or in mouse kidney after ischemia/reperfusion (I/R) injury by Western blotting.	Hydrogen Peroxide	62-79	signal transducer and activator of transcription 3	Mus musculus	41-46
16788692-9	2006	On the other hand, both I/R and severe oxidative stress - but not moderate stress - increased tyrosine phosphorylation of STAT3 in an EGFR and JAK2-dependent manner.	Tyrosine	94-102	signal transducer and activator of transcription 3	Mus musculus	122-127
16788692-11	2006	Our data suggest a role of tyrosine-phosphorylated STAT3 in the suppression of ERK activation.	Tyrosine	27-35	signal transducer and activator of transcription 3	Mus musculus	51-56
16998532-8	2006	CB1-receptor-mediated Rap1 activation leads to the activation of a signaling network that includes the small guanosine triphosphate (GTP)ases Ral and Rac, the protein kinases Src, and c-Jun N-terminal kinase (JNK), which converge onto the activation of signal transducer and activator of transcription 3 (Stat3), a key transcription factor that mediates the gene expression process of neurite outgrowth in Neuro2A cells.	Guanosine Triphosphate	133-136	signal transducer and activator of transcription 3	Mus musculus	253-303
16953121-8	2006	Oh(8)dG apparently plays a role in anti-inflammatory actions via suppression of ICAM-1 gene expression by blockade of the TLR4-STAT3 signal cascade in inflammation-enhanced brain microglia.	oh(8)dg	0-7	signal transducer and activator of transcription 3	Mus musculus	127-132
16601124-10	2006	These results demonstrate an important role of Tyk2-mediated tyrosine phosphorylation of Stat3 in the ability of IFNbeta to stimulate apoptosis of primary pro-B cells.	Tyrosine	61-69	signal transducer and activator of transcription 3	Mus musculus	89-94
16706685-5	2006	Moreover, DCs expressing activated STAT3 also express the tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase.	Tryptophan	58-68	signal transducer and activator of transcription 3	Mus musculus	35-40
16627594-0	2006	Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3.	Estradiol	28-37	signal transducer and activator of transcription 3	Mus musculus	187-237
16627594-8	2006	We also present data showing that Stat3 is rapidly induced by estradiol in mouse livers.	Estradiol	62-71	signal transducer and activator of transcription 3	Mus musculus	34-39
16547967-8	2006	Treatment of activated T cells with 1,25(OH)2D3 also inhibited the IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro.	Calcitriol	36-47	signal transducer and activator of transcription 3	Mus musculus	121-126
16547967-8	2006	Treatment of activated T cells with 1,25(OH)2D3 also inhibited the IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro.	Tyrosine	81-89	signal transducer and activator of transcription 3	Mus musculus	121-126
16953121-0	2006	Anti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression.	8-ohdg	29-52	signal transducer and activator of transcription 3	Mus musculus	105-110
16953121-2	2006	We found that oh(8)dG reduces LPS-induced reactive oxygen species (ROS) production, STAT3 activation, and ICAM-1 expression.	oh(8)dg	14-21	signal transducer and activator of transcription 3	Mus musculus	84-89
16953121-5	2006	Chromatin immunoprecipitation studies revealed that oh(8)dG inhibited recruitment of STAT3 to the ICAM-1 promoter, followed by a decrease in ICAM-1 expression.	oh(8)dg	52-59	signal transducer and activator of transcription 3	Mus musculus	85-90
16718380-5	2006	Using reconstitution into Stat3-/- mouse embryonic fibroblasts (Stat3-/- MEFs), we find that a STAT3 N-domain deletion mutant (Delta 133STAT3) is activated by tyrosine phosphorylation in response to IL-6 and then undergoes dephosphorylation with kinetics similar to full-length STAT3.	Tyrosine	159-167	signal transducer and activator of transcription 3	Mus musculus	95-100
16718380-5	2006	Using reconstitution into Stat3-/- mouse embryonic fibroblasts (Stat3-/- MEFs), we find that a STAT3 N-domain deletion mutant (Delta 133STAT3) is activated by tyrosine phosphorylation in response to IL-6 and then undergoes dephosphorylation with kinetics similar to full-length STAT3.	Tyrosine	159-167	signal transducer and activator of transcription 3	Mus musculus	136-141
16998532-8	2006	CB1-receptor-mediated Rap1 activation leads to the activation of a signaling network that includes the small guanosine triphosphate (GTP)ases Ral and Rac, the protein kinases Src, and c-Jun N-terminal kinase (JNK), which converge onto the activation of signal transducer and activator of transcription 3 (Stat3), a key transcription factor that mediates the gene expression process of neurite outgrowth in Neuro2A cells.	Guanosine Triphosphate	109-131	signal transducer and activator of transcription 3	Mus musculus	253-303
16998532-8	2006	CB1-receptor-mediated Rap1 activation leads to the activation of a signaling network that includes the small guanosine triphosphate (GTP)ases Ral and Rac, the protein kinases Src, and c-Jun N-terminal kinase (JNK), which converge onto the activation of signal transducer and activator of transcription 3 (Stat3), a key transcription factor that mediates the gene expression process of neurite outgrowth in Neuro2A cells.	Guanosine Triphosphate	109-131	signal transducer and activator of transcription 3	Mus musculus	305-310
16814732-5	2006	Likewise, hypothalamic signaling of leptin through STAT3 is required for the acute effects of leptin on liver glucose fluxes.	Glucose	110-117	signal transducer and activator of transcription 3	Mus musculus	51-56
16601124-7	2006	In contrast to IFNbeta-stimulated tyrosine phosphorylation of Stat1 and Stat2, Stat3 tyrosine phosphorylation is defective in Tyk2(-/-) pro-B cells, suggesting that this Stat family member is required for apoptosis.	Tyrosine	85-93	signal transducer and activator of transcription 3	Mus musculus	79-84
16641140-8	2006	We demonstrate the importance of STAT3 and STAT5 in mediating the G-CSF response with respect to p120 expression by transient transfection analysis, oligonucleotide pull-down assays, and the loss of p120 expression in the bone marrow of mice lacking normal STAT3 signaling.	Oligonucleotides	149-164	signal transducer and activator of transcription 3	Mus musculus	33-38
16998532-8	2006	CB1-receptor-mediated Rap1 activation leads to the activation of a signaling network that includes the small guanosine triphosphate (GTP)ases Ral and Rac, the protein kinases Src, and c-Jun N-terminal kinase (JNK), which converge onto the activation of signal transducer and activator of transcription 3 (Stat3), a key transcription factor that mediates the gene expression process of neurite outgrowth in Neuro2A cells.	Guanosine Triphosphate	133-136	signal transducer and activator of transcription 3	Mus musculus	305-310
16473883-3	2006	In mouse livers and bone marrow-derived macrophages, both interferon-gamma (IFNgamma) and interleukin-6 (IL-6) rapidly induced the tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT1) and STAT3.	Tyrosine	131-139	signal transducer and activator of transcription 3	Mus musculus	222-227
16473883-4	2006	STAT3 tyrosine phosphorylation was bi-phasic in response to continuous IL-6 signaling.	Tyrosine	6-14	signal transducer and activator of transcription 3	Mus musculus	0-5
16988490-0	2006	Identification of Jmjd1a as a STAT3 downstream gene in mES cells.	2-(N-morpholino)ethanesulfonic acid	55-58	signal transducer and activator of transcription 3	Mus musculus	30-35
16581004-0	2006	Role of hepatic STAT3 in brain-insulin action on hepatic glucose production.	Glucose	57-64	signal transducer and activator of transcription 3	Mus musculus	16-21
16581004-1	2006	STAT3 regulates glucose homeostasis by suppressing the expression of gluconeogenic genes in the liver.	Glucose	16-23	signal transducer and activator of transcription 3	Mus musculus	0-5
16581004-3	2006	Here, we show that an increase in the plasma insulin concentration, achieved either by glucose administration or by intravenous insulin infusion, stimulates tyrosine phosphorylation of STAT3 in the liver.	Glucose	87-94	signal transducer and activator of transcription 3	Mus musculus	185-190
16581004-3	2006	Here, we show that an increase in the plasma insulin concentration, achieved either by glucose administration or by intravenous insulin infusion, stimulates tyrosine phosphorylation of STAT3 in the liver.	Tyrosine	157-165	signal transducer and activator of transcription 3	Mus musculus	185-190
16581004-6	2006	These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production.	Glucose	149-156	signal transducer and activator of transcription 3	Mus musculus	38-43
16554031-4	2006	Moreover, we show that TSA interfered with STAT3-dependent transcriptional activity induced by PDGF.	trichostatin A	23-26	signal transducer and activator of transcription 3	Mus musculus	43-48
16536977-3	2006	This study was to observe the activation of STAT3 protein in mouse melanoma cell line B16, human liver cancer cell lines SMMC-7721 and HepG-2, human lung cancer cell line A549, and human cervical cancer cell line HeLa, and to investigate the effects of STAT3 antisense oligodeoxynucleotides (ASODN) on proliferation and apoptosis of B16 cells.	Oligodeoxyribonucleotides	269-290	signal transducer and activator of transcription 3	Mus musculus	44-49
16536977-3	2006	This study was to observe the activation of STAT3 protein in mouse melanoma cell line B16, human liver cancer cell lines SMMC-7721 and HepG-2, human lung cancer cell line A549, and human cervical cancer cell line HeLa, and to investigate the effects of STAT3 antisense oligodeoxynucleotides (ASODN) on proliferation and apoptosis of B16 cells.	asodn	292-297	signal transducer and activator of transcription 3	Mus musculus	44-49
16373613-0	2006	Identification of the cAMP-responsive enhancer of the murine ABCA1 gene: requirement for CREB1 and STAT3/4 elements.	Cyclic AMP	22-26	signal transducer and activator of transcription 3	Mus musculus	99-106
16373613-6	2006	Furthermore, the capacity of this CRE site to mediate the cAMP induction required the presence of a STAT3/4 element located 81 bp away.	Cyclic AMP	58-62	signal transducer and activator of transcription 3	Mus musculus	100-107
16417589-6	2006	Pretreatment with a JAK inhibitor, AG-490, suppressed phosphorylation of JAK1 and STAT3 at 12 h after SCI, reducing recovery of motor functions.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	35-41	signal transducer and activator of transcription 3	Mus musculus	82-87
16328104-7	2006	The improvement of colitis by pioglitazone was associated with decreased colonic interleukin-6, and phospho-signal transducer and activator of transcription-3 levels.	Pioglitazone	30-42	signal transducer and activator of transcription 3	Mus musculus	108-158
16893056-2	2006	Recently, we showed transactivation of EGFR and activation of transcription factor STAT3, rather than STAT1, induced by glutathione disulfide (GSSG) and glutoxim in epidermoid carcinoma A431 cells (Burova et al., Dokl.	Glutathione Disulfide	120-141	signal transducer and activator of transcription 3	Mus musculus	83-88
16418805-8	2006	The COX-2 inhibitors also decreased IL-12-induced T cell responses through blocking tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4 proteins in T cells.	Tyrosine	84-92	signal transducer and activator of transcription 3	Mus musculus	124-129
16893056-2	2006	Recently, we showed transactivation of EGFR and activation of transcription factor STAT3, rather than STAT1, induced by glutathione disulfide (GSSG) and glutoxim in epidermoid carcinoma A431 cells (Burova et al., Dokl.	Glutathione Disulfide	143-147	signal transducer and activator of transcription 3	Mus musculus	83-88
16893056-2	2006	Recently, we showed transactivation of EGFR and activation of transcription factor STAT3, rather than STAT1, induced by glutathione disulfide (GSSG) and glutoxim in epidermoid carcinoma A431 cells (Burova et al., Dokl.	glutoxim	153-161	signal transducer and activator of transcription 3	Mus musculus	83-88
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Tyrosine	49-52	signal transducer and activator of transcription 3	Mus musculus	300-305
16226915-10	2005	These data suggest that obese subjects in the persistent inflammatory states, such as elevated circulating tumor necrosis factor-alpha, may have down-regulated STAT3-mediated signaling by increased SOCS proteins, leading to up-regulation of SREBP-1c expression and increased fatty acid synthesis in liver.	Fatty Acids	275-285	signal transducer and activator of transcription 3	Mus musculus	160-165
16046413-5	2005	The CB1 agonist HU-210 induced pertussis toxin-sensitive Src and Stat3 phosphorylation.	HU 211	16-22	signal transducer and activator of transcription 3	Mus musculus	65-70
16102856-4	2005	Computer algorithms identified several islet-associated and glucose-responsive binding motifs that included A and E boxes, hepatocyte nuclear factors 1 and 4, Oct-1, and signal transducer and activator of transcription 3, and 5.	Glucose	60-67	signal transducer and activator of transcription 3	Mus musculus	170-227
16505101-0	2006	Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer.	g-quartet oligonucleotides	66-92	signal transducer and activator of transcription 3	Mus musculus	10-60
16505101-3	2006	Recently, we developed a series of G-quartet oligodeoxynucleotides (GQ-ODN) as novel and potent Stat3 inhibitors, which significantly suppressed the growth of prostate and breast tumors in nude mice.	g-quartet oligodeoxynucleotides	35-66	signal transducer and activator of transcription 3	Mus musculus	96-101
16505101-3	2006	Recently, we developed a series of G-quartet oligodeoxynucleotides (GQ-ODN) as novel and potent Stat3 inhibitors, which significantly suppressed the growth of prostate and breast tumors in nude mice.	gq-odn	68-74	signal transducer and activator of transcription 3	Mus musculus	96-101
16170336-3	2005	The inhibition of NPM/ALK activity resulted in malignant T cells in suppression of their growth, induction of apoptosis and inhibition of tyrosine phosphorylation of STAT3, the key effector of the NPM/ALK-induced oncogenesis.	Tyrosine	138-146	signal transducer and activator of transcription 3	Mus musculus	166-171
16170336-4	2005	We also show that the STAT3 tyrosine phosphorylation is mediated in the malignant T cells by NPM/ALK independently of Jak3 kinase as evidenced by the presence of STAT3 phosphorylation in the NPM/ALK-transfected BaF3 cells that do not express detectable Jak3 and in the NPM/ALK-positive malignant T cells with either Jak3 activity impaired by a pan-Jak or Jak3-selective inhibitor or Jak3 expression abrogated by Jak3 siRNA.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	22-27
16170336-4	2005	We also show that the STAT3 tyrosine phosphorylation is mediated in the malignant T cells by NPM/ALK independently of Jak3 kinase as evidenced by the presence of STAT3 phosphorylation in the NPM/ALK-transfected BaF3 cells that do not express detectable Jak3 and in the NPM/ALK-positive malignant T cells with either Jak3 activity impaired by a pan-Jak or Jak3-selective inhibitor or Jak3 expression abrogated by Jak3 siRNA.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	162-167
16285960-1	2005	BACKGROUND & AIMS: The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes.	Adenosine Monophosphate	12-15	signal transducer and activator of transcription 3	Mus musculus	79-84
16285960-6	2005	RESULTS: Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 terminus are acetylated by p300.	Lysine	13-16	signal transducer and activator of transcription 3	Mus musculus	58-63
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	signal transducer and activator of transcription 3	Mus musculus	28-33
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	signal transducer and activator of transcription 3	Mus musculus	122-127
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	signal transducer and activator of transcription 3	Mus musculus	28-33
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	signal transducer and activator of transcription 3	Mus musculus	122-127
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Tyrosine	49-52	signal transducer and activator of transcription 3	Mus musculus	414-419
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Serine	267-270	signal transducer and activator of transcription 3	Mus musculus	300-305
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Serine	267-270	signal transducer and activator of transcription 3	Mus musculus	414-419
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Serine	381-384	signal transducer and activator of transcription 3	Mus musculus	300-305
16172266-1	2005	BACKGROUND: Although Janus kinase (JAK)-mediated Tyr phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 is essential for the upregulation of cyclooxygenase-2 (COX-2) and the cardioprotection of late preconditioning (PC), the role of Ser phosphorylation of STAT1 and STAT3 in late PC and the upstream signaling mechanisms responsible for mediating Ser phosphorylation of STAT1 and STAT3 remain unknown.	Serine	381-384	signal transducer and activator of transcription 3	Mus musculus	414-419
16172266-3	2005	CONCLUSIONS: To our knowledge, this is the first study to demonstrate that ischemic PC causes Ser phosphorylation of STAT1 and STAT3 and that this event is governed by PKCepsilon via a PKCepsilon-Raf1-MEK1/2-p44/42 MAPK pathway.	Serine	94-97	signal transducer and activator of transcription 3	Mus musculus	127-132
15917293-2	2005	The results demonstrate that growth rate, formation of foci overgrowing a monolayer of normal cells and colony formation in soft agar were dramatically reduced in Stat3-deficient cells.	Agar	129-133	signal transducer and activator of transcription 3	Mus musculus	163-168
16116228-6	2005	Stat3 was tyrosine phosphorylated in peritoneal resident macrophages as well as infiltrating leukocytes in the littermate controls, suggesting that Stat3 in either or both of these cells might play a regulatory role in inflammation.	Tyrosine	10-18	signal transducer and activator of transcription 3	Mus musculus	0-5
16116228-6	2005	Stat3 was tyrosine phosphorylated in peritoneal resident macrophages as well as infiltrating leukocytes in the littermate controls, suggesting that Stat3 in either or both of these cells might play a regulatory role in inflammation.	Tyrosine	10-18	signal transducer and activator of transcription 3	Mus musculus	148-153
15917293-3	2005	In addition, TAg expression led to increased Stat3 tyrosine phosphorylation, DNA binding, and transcriptional activity, suggesting that Stat3 is required for TAg-mediated neoplasia.	Tyrosine	51-59	signal transducer and activator of transcription 3	Mus musculus	45-50
15936723-0	2005	Ultraviolet B exposure activates Stat3 signaling via phosphorylation at tyrosine705 in skin of SKH1 hairless mouse: a target for the management of skin cancer?	tyrosine705	72-83	signal transducer and activator of transcription 3	Mus musculus	33-38
15936723-4	2005	Our data demonstrated that a single UVB (180 mJ/cm(2)) exposure to the skin of SKH-1 hairless mice resulted in significant upregulation in (i) protein levels of Stat3 and (ii) phosphorylation of Stat3 at tyrosine(705).	Tyrosine	204-212	signal transducer and activator of transcription 3	Mus musculus	161-166
15936723-4	2005	Our data demonstrated that a single UVB (180 mJ/cm(2)) exposure to the skin of SKH-1 hairless mice resulted in significant upregulation in (i) protein levels of Stat3 and (ii) phosphorylation of Stat3 at tyrosine(705).	Tyrosine	204-212	signal transducer and activator of transcription 3	Mus musculus	195-200
15746079-5	2005	In cell lines expressing activation-loop mutants, low-nM concentrations of AP23464 inhibited phosphorylation of Kit and its downstream targets Akt and signal transducer and activator of transcription 3 (STAT3).	AP23464	75-82	signal transducer and activator of transcription 3	Mus musculus	151-201
15746079-5	2005	In cell lines expressing activation-loop mutants, low-nM concentrations of AP23464 inhibited phosphorylation of Kit and its downstream targets Akt and signal transducer and activator of transcription 3 (STAT3).	AP23464	75-82	signal transducer and activator of transcription 3	Mus musculus	203-208
15978261-5	2005	STAT3 activation was detected in the outermost retina layer in response to CNTF, LIF, FGF1, and IFN-alpha 24 hr after stimulation in postnatal day 1 (PN1) explants, but not FGF2, EGF, IFN-gamma, and retinoic acid (RA).	Tretinoin	199-212	signal transducer and activator of transcription 3	Mus musculus	0-5
15978261-5	2005	STAT3 activation was detected in the outermost retina layer in response to CNTF, LIF, FGF1, and IFN-alpha 24 hr after stimulation in postnatal day 1 (PN1) explants, but not FGF2, EGF, IFN-gamma, and retinoic acid (RA).	Tretinoin	214-216	signal transducer and activator of transcription 3	Mus musculus	0-5
15778348-9	2005	TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production.	Nitrites	219-226	signal transducer and activator of transcription 3	Mus musculus	46-51
15910996-3	2005	Cell proliferation and tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT3) were induced by rchIL-6 in the IL-6-dependent murine hybridoma cell line MH60, whereas the recombinant protein exhibited no significant cell proliferation activity in chicken hybridoma cells but induced antibody production and tyrosine phosphorylation of STAT3.	Tyrosine	23-31	signal transducer and activator of transcription 3	Mus musculus	51-101
15910996-3	2005	Cell proliferation and tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT3) were induced by rchIL-6 in the IL-6-dependent murine hybridoma cell line MH60, whereas the recombinant protein exhibited no significant cell proliferation activity in chicken hybridoma cells but induced antibody production and tyrosine phosphorylation of STAT3.	Tyrosine	23-31	signal transducer and activator of transcription 3	Mus musculus	103-108
15910996-3	2005	Cell proliferation and tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT3) were induced by rchIL-6 in the IL-6-dependent murine hybridoma cell line MH60, whereas the recombinant protein exhibited no significant cell proliferation activity in chicken hybridoma cells but induced antibody production and tyrosine phosphorylation of STAT3.	Tyrosine	337-345	signal transducer and activator of transcription 3	Mus musculus	51-101
15910996-3	2005	Cell proliferation and tyrosine phosphorylation of signal transducer and activator of transcription-3 (STAT3) were induced by rchIL-6 in the IL-6-dependent murine hybridoma cell line MH60, whereas the recombinant protein exhibited no significant cell proliferation activity in chicken hybridoma cells but induced antibody production and tyrosine phosphorylation of STAT3.	Tyrosine	337-345	signal transducer and activator of transcription 3	Mus musculus	103-108
16025117-4	2005	The anti-inflammatory effect of nicotine required the ability of phosphorylated STAT3 to bind and transactivate its DNA response elements.	Nicotine	32-40	signal transducer and activator of transcription 3	Mus musculus	80-85
15838885-9	2005	NGF-stimulation of the heterologous receptor system evoked activation of STAT3 as evidenced by tyrosine phosphorylation and the formation of STAT3 clusters at the cell membrane.	Tyrosine	95-103	signal transducer and activator of transcription 3	Mus musculus	73-78
15923602-2	2005	In the present study, we explored the capacity of progestins to modulate Stat3 transcriptional activation in an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in BALB/c mice and in the human breast cancer cell line T47D.	Medroxyprogesterone Acetate	191-218	signal transducer and activator of transcription 3	Mus musculus	73-78
15735720-0	2005	Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.	cucurbitacin Q	0-14	signal transducer and activator of transcription 3	Mus musculus	28-33
15735720-2	2005	In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits JAK2 but not STAT3 activation; and Cuc B, E, and I, which inhibit the activation of both.	Cucurbitacins	78-90	signal transducer and activator of transcription 3	Mus musculus	189-194
15735720-2	2005	In the present study, structure-activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and Q, led to the discovery of Cuc Q, which inhibits the activation of STAT3 but not JAK2; Cuc A which inhibits JAK2 but not STAT3 activation; and Cuc B, E, and I, which inhibit the activation of both.	Cucurbitacins	92-95	signal transducer and activator of transcription 3	Mus musculus	189-194
15735720-3	2005	Furthermore, these SAR studies demonstrated that conversion of the C3 carbonyl of the cucurbitacins to a hydroxyl results in loss of anti-JAK2 activity, whereas addition of a hydroxyl group to C11 of the cucurbitacins results in loss of anti-STAT3 activity.	Cucurbitacins	86-99	signal transducer and activator of transcription 3	Mus musculus	242-247
15735720-4	2005	Cuc Q inhibits selectively the activation of STAT3 and induces apoptosis without inhibition of JAK2, Src, Akt, Erk, or JNK activation.	cucurbitacin Q	0-5	signal transducer and activator of transcription 3	Mus musculus	45-50
15735720-5	2005	Furthermore, Cuc Q induces apoptosis more potently in human and murine tumors that contain constitutively activated STAT3 (i.e., A549, MDA-MB-435, and v-Src/NIH 3T3) as compared to those that do not (i.e., H-Ras/NIH 3T3, MDA-MB-453, and NIH 3T3 cells).	cucurbitacin Q	13-18	signal transducer and activator of transcription 3	Mus musculus	116-121
15705584-3	2005	We also found that although active RhoA, Rac1, and Cdc42 could all mediate Ser-727 and Tyr-705 phosphorylation and nuclear translocation of STAT3, the Rho GTPases were able to induce STAT3 activation independently of the interleukin-6 autocrine pathway, and active RhoA, Rac1, or Cdc42 could not form a stable complex with STAT3 as previously suggested, indicating an unappreciated mechanism of STAT3 activation by the Rho GTPases.	Serine	75-78	signal transducer and activator of transcription 3	Mus musculus	140-145
15778348-0	2005	Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects.	Nitric Oxide	80-92	signal transducer and activator of transcription 3	Mus musculus	0-5
15778348-9	2005	TNF-alpha and IFN-beta, which are secreted by Stat3-inhibited tumor cells, are able to activate macrophage NO production, whereas neutralizing TNF-alpha in the tumor supernatant from Stat3-blocked tumor cells abrogates nitrite production.	Nitrites	219-226	signal transducer and activator of transcription 3	Mus musculus	183-188
15778348-10	2005	Moreover, interrupting Stat3 signaling in tumor cells leads to macrophage-mediated, nitrite-dependent cytostatic activity against nontransduced tumor cells.	Nitrites	84-91	signal transducer and activator of transcription 3	Mus musculus	23-28
15659653-6	2005	In vivo, the tyrosine-phosphorylated Stat3 was colocalized with Isl1 in the nucleus of the mouse motor neurons in spinal cord after nerve injury.	Tyrosine	13-21	signal transducer and activator of transcription 3	Mus musculus	37-42
15671076-11	2005	A short IL-15 stimulation of TEC induced tyrosine phosphorylation of the main IL-15 signalling molecules (Jak-1, Jak-3, STAT-3 and STAT-5).	Tyrosine	41-49	signal transducer and activator of transcription 3	Mus musculus	120-126
15821101-2	2005	The transient character of the tyrosine phosphorylation of JAK2 and STAT3 suggests the involvement of protein tyrosine phosphatases (PTPs) as negative regulators of this signalling pathway.	Tyrosine	31-39	signal transducer and activator of transcription 3	Mus musculus	68-73
15649407-6	2005	The Src kinase inhibitor SU6656 suppressed IFN-gamma activation of Stat3 in both wild-type and Stat1-/- fibroblasts.	SU 6656	25-31	signal transducer and activator of transcription 3	Mus musculus	67-72
15558059-0	2005	Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation.	Proline	6-13	signal transducer and activator of transcription 3	Mus musculus	70-75
15639482-8	2005	Finally, homozygous deletion of the MT1 and MT2 genes abrogated cardioprotective effect of STAT3 against I/R injury with the cancellation of its ROS-scavenging effects.	Reactive Oxygen Species	145-148	signal transducer and activator of transcription 3	Mus musculus	91-96
15647843-3	2005	To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT).	hydroxytamoxifen	101-119	signal transducer and activator of transcription 3	Mus musculus	46-51
15647843-3	2005	To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT).	hydroxytamoxifen	101-119	signal transducer and activator of transcription 3	Mus musculus	67-72
15647843-3	2005	To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT).	4'-hydroxytamoxifen	121-124	signal transducer and activator of transcription 3	Mus musculus	46-51
15647843-3	2005	To address this issue, we have established M1/STAT3ER cells, where STAT3 is selectively activated by 4-hydroxytamoxifen (4HT).	4'-hydroxytamoxifen	121-124	signal transducer and activator of transcription 3	Mus musculus	67-72
15451030-7	2005	Further, Lyn was required for SCF-induced tyrosine phosphorylation of Stat3.	Tyrosine	42-50	signal transducer and activator of transcription 3	Mus musculus	70-75
15816866-2	2005	Demethylation of the methyl-CpG dinucleotide in the STAT3 binding site in the promoter of the glial fibrillary acidic protein (GFAP) gene, a marker for astrocytes, was previously shown to be a crucial cue for neural progenitors to express this gene in response to astrogenic signals during brain development.	methyl-cpg dinucleotide	21-44	signal transducer and activator of transcription 3	Mus musculus	52-57
15816866-4	2005	The CpG dinucleotide in the STAT3 binding site in the GFAP gene promoter exhibited a high incidence of cytidine-methylation in undifferentiated pluripotent ES cells.	Dinucleoside Phosphates	8-20	signal transducer and activator of transcription 3	Mus musculus	28-33
15816866-4	2005	The CpG dinucleotide in the STAT3 binding site in the GFAP gene promoter exhibited a high incidence of cytidine-methylation in undifferentiated pluripotent ES cells.	Cytidine	103-111	signal transducer and activator of transcription 3	Mus musculus	28-33
15816866-5	2005	The high incidence of methylation of this particular cytidine was maintained in ES cell-derived neuroectoderm-like cells, but it underwent demethylation when the neural lineage cells became competent to express GFAP in response to a STAT3 activation signal.	Cytidine	53-61	signal transducer and activator of transcription 3	Mus musculus	233-238
15378015-1	2004	Induced transformation of mouse fibroblasts was carried out by releasing tetracycline-repressed expression of an oncogenic mutant of STAT3, STAT3-C, or of v-Src or Ha-Ras.	Tetracycline	73-85	signal transducer and activator of transcription 3	Mus musculus	133-138
15284113-5	2004	MgcRacGAP, Rac, and STAT3 formed a complex in IL-6-stimulated M1 cells, where MgcRacGAP interacted with Rac1 and STAT3 through its cysteine-rich domain and GAP domain.	Cysteine	131-139	signal transducer and activator of transcription 3	Mus musculus	20-25
15284113-5	2004	MgcRacGAP, Rac, and STAT3 formed a complex in IL-6-stimulated M1 cells, where MgcRacGAP interacted with Rac1 and STAT3 through its cysteine-rich domain and GAP domain.	Cysteine	131-139	signal transducer and activator of transcription 3	Mus musculus	113-118
15467733-2	2004	Herein we show that TMF/ARA160 can direct the proteasomal degradation of the key cell growth regulator - Stat3.	ara160	24-30	signal transducer and activator of transcription 3	Mus musculus	105-110
15467733-4	2004	The cytoplasmic distribution of TMF/ARA160 was accompanied by its transient association with the tyrosine kinase Fer and with Stat3, which underwent proteasomal degradation under those conditions.	ara160	36-42	signal transducer and activator of transcription 3	Mus musculus	126-131
15467733-8	2004	Ectopic expression of TMF/ARA160 in serum-starved C2C12 cells drove the ubiquitination and proteasomal degradation of Stat3, an effect that was not caused by TMF/ARA160 devoid of the BC-box motif.	ara160	26-32	signal transducer and activator of transcription 3	Mus musculus	118-123
15592573-5	2005	Finally, abrogation of Stat3 function by a decoy oligonucleotide inhibits the onset and reverses established psoriatic lesions in K5.Stat3C mice.	Oligonucleotides	49-64	signal transducer and activator of transcription 3	Mus musculus	23-28
15378015-1	2004	Induced transformation of mouse fibroblasts was carried out by releasing tetracycline-repressed expression of an oncogenic mutant of STAT3, STAT3-C, or of v-Src or Ha-Ras.	Tetracycline	73-85	signal transducer and activator of transcription 3	Mus musculus	140-145
15292206-7	2004	Stat3 tyrosine and serine phosphorylation was still detected in these mice suggesting that Stat3 activation could be the result of gp130 interfacing with other receptors.	Tyrosine	6-14	signal transducer and activator of transcription 3	Mus musculus	0-5
15189833-6	2004	A similar distribution was also observed for the serine (S727p) phosphorylated form of STAT3 as well as for tyrosine (Y689p) phosphorylated STAT2.	Serine	49-55	signal transducer and activator of transcription 3	Mus musculus	87-92
15064234-0	2004	Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways.	Alcohols	8-15	signal transducer and activator of transcription 3	Mus musculus	122-127
15284232-4	2004	In response to IFNgamma, SRC-family kinases are required to activate STAT3 (but not STAT1) through tyrosine phosphorylation, whereas the receptor-bound kinases JAK1 and JAK2 are required to activate both STATs.	Tyrosine	99-107	signal transducer and activator of transcription 3	Mus musculus	69-74
15284232-5	2004	Tyrosine 419 of the IFNgamma receptor subunit 1 (IFNGR1) is required to activate both STATs, suggesting that STAT1 and STAT3 compete with each other for the same receptor phosphotyrosine motif.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	119-124
15284232-5	2004	Tyrosine 419 of the IFNgamma receptor subunit 1 (IFNGR1) is required to activate both STATs, suggesting that STAT1 and STAT3 compete with each other for the same receptor phosphotyrosine motif.	Phosphotyrosine	171-186	signal transducer and activator of transcription 3	Mus musculus	119-124
15365247-5	2004	Interestingly, the longer maintenance of activated status was accompanied with more increase of tyrosine phosphorylation of Stat3 protein.	Tyrosine	96-104	signal transducer and activator of transcription 3	Mus musculus	124-129
15374974-0	2004	G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis.	g-quartet oligonucleotides	0-26	signal transducer and activator of transcription 3	Mus musculus	43-93
15374974-2	2004	We recently developed G-rich oligodeoxynucleotides, which form intramolecular G-quartet structures (GQ-ODN), as a new class of Stat3 inhibitor.	g-rich oligodeoxynucleotides	22-50	signal transducer and activator of transcription 3	Mus musculus	127-132
15374974-2	2004	We recently developed G-rich oligodeoxynucleotides, which form intramolecular G-quartet structures (GQ-ODN), as a new class of Stat3 inhibitor.	gq-odn	100-106	signal transducer and activator of transcription 3	Mus musculus	127-132
15374974-4	2004	When delivered into cells using polyethyleneimine as vehicle, GQ-ODN blocked ligand-induced Stat3 activation and Stat3-mediated transcription of antiapoptotic genes.	aziridine	32-49	signal transducer and activator of transcription 3	Mus musculus	92-97
15374974-9	2004	Thus, GQ-ODN targeting Stat3 induces tumor cell apoptosis when delivered into tumor xenografts and represents a novel class of chemotherapeutic agents that holds promise for the systemic treatment of many forms of metastatic cancer.	gq-odn	6-12	signal transducer and activator of transcription 3	Mus musculus	23-28
15343391-3	2004	The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression.	Tetradecanoylphorbol Acetate	136-172	signal transducer and activator of transcription 3	Mus musculus	17-22
15343391-3	2004	The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression.	Tetradecanoylphorbol Acetate	174-177	signal transducer and activator of transcription 3	Mus musculus	17-22
15343391-4	2004	Treatment with the tumor initiator 7,12-dimethylbenz[a]anthracene (DMBA) resulted in a significant increase in the number of keratinocyte stem cells undergoing apoptosis in the bulge region of hair follicles of Stat3-deficient mice compared with nontransgenic littermates.	9,10-Dimethyl-1,2-benzanthracene	35-65	signal transducer and activator of transcription 3	Mus musculus	211-216
15343391-4	2004	Treatment with the tumor initiator 7,12-dimethylbenz[a]anthracene (DMBA) resulted in a significant increase in the number of keratinocyte stem cells undergoing apoptosis in the bulge region of hair follicles of Stat3-deficient mice compared with nontransgenic littermates.	9,10-Dimethyl-1,2-benzanthracene	67-71	signal transducer and activator of transcription 3	Mus musculus	211-216
15343391-5	2004	Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter.	9,10-Dimethyl-1,2-benzanthracene	87-91	signal transducer and activator of transcription 3	Mus musculus	9-14
15343391-5	2004	Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter.	Tetradecanoylphorbol Acetate	122-125	signal transducer and activator of transcription 3	Mus musculus	9-14
15343391-6	2004	Abrogation of Stat3 function using a decoy oligonucleotide inhibited the growth of initiated keratinocytes possessing an activated Ha-ras gene, both in vitro and in vivo.	Oligonucleotides	43-58	signal transducer and activator of transcription 3	Mus musculus	14-19
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Quercetin	45-54	signal transducer and activator of transcription 3	Mus musculus	116-121
15359113-5	2004	In vitro treatment of activated T cells with quercetin blocks IL-12-induced tyrosine phosphorylation of JAK2, TYK2, STAT3, and STAT4, resulting in a decrease in IL-12-induced T cell proliferation and Th1 differentiation.	Tyrosine	76-84	signal transducer and activator of transcription 3	Mus musculus	116-121
15064234-0	2004	Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways.	Alcohols	83-90	signal transducer and activator of transcription 3	Mus musculus	122-127
15064234-6	2004	Moreover, Con A-induced activation of hepatic NF-kappaB is increased, whereas activation of STAT1 and STAT3 is attenuated in ethanol-fed mice.	Ethanol	125-132	signal transducer and activator of transcription 3	Mus musculus	102-107
15194489-8	2004	Intraperitoneal glucose tolerance tests, performed in non-obese 5-week-old mice, showed that the STAT3-insKO mice were glucose intolerant.	Glucose	16-23	signal transducer and activator of transcription 3	Mus musculus	97-102
15191552-10	2004	STAT3 tyrosine phosphorylation was induced after barrier disruption in wild-type, but markedly reduced in IL-6-deficient mice.	Tyrosine	6-14	signal transducer and activator of transcription 3	Mus musculus	0-5
15208705-4	2004	Compared to their wild-type littermates, Socs3-deficient mice showed enhanced leptin-induced hypothalamic Stat3 tyrosine phosphorylation as well as pro-opiomelanocortin (POMC) induction, and this resulted in a greater body weight loss and suppression of food intake.	Tyrosine	112-120	signal transducer and activator of transcription 3	Mus musculus	106-111
15188379-0	2004	Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice.	Zymosan	70-77	signal transducer and activator of transcription 3	Mus musculus	31-37
15194489-12	2004	Our present observations demonstrate a unique role of STAT3 in maintaining glucose-mediated early-phase insulin secretion and normal islet morphology.	Glucose	75-82	signal transducer and activator of transcription 3	Mus musculus	54-59
15044588-9	2004	To assess Stat3 physiological function, overexpression of a dominant negative Stat3 in respiratory epithelial cells in a doxycycline-controlled double transgenic mouse line caused pulmonary emphysema and increase of animal death during hyperoxia.	Doxycycline	121-132	signal transducer and activator of transcription 3	Mus musculus	78-83
15096606-4	2004	We report here that the Cdk5/p35 complex associates with STAT3 and phosphorylates STAT3 on the Ser-727 residue in vitro and in vivo.	Serine	95-98	signal transducer and activator of transcription 3	Mus musculus	57-62
15096606-4	2004	We report here that the Cdk5/p35 complex associates with STAT3 and phosphorylates STAT3 on the Ser-727 residue in vitro and in vivo.	Serine	95-98	signal transducer and activator of transcription 3	Mus musculus	82-87
15096606-5	2004	Intriguingly, whereas the Ser phosphorylation of STAT3 can be detected in embryonic and postnatal brain and muscle of wild-type mice, it is essentially absent from those of Cdk5-deficient embryos.	Serine	26-29	signal transducer and activator of transcription 3	Mus musculus	49-54
15096606-6	2004	In addition, treatment of cultured myotubes with neuregulin enhances the Ser phosphorylation of STAT3 and transcription of STAT3 target genes, such as c-fos and junB, in a Cdk5-dependent manner.	Serine	73-76	signal transducer and activator of transcription 3	Mus musculus	96-101
14742442-7	2004	Even though IFNgamma triggered tyrosine phosphorylation of both STAT1 and STAT3 in macrophages and J774 cells, only STAT1 was appropriately activated and thus found to specifically bind to the SOCS-3/SBE oligonucleotide probe.	Tyrosine	31-39	signal transducer and activator of transcription 3	Mus musculus	74-79
14729671-6	2004	Treatment of cultured C2C12 myotubes with ephrin-A1 also induced tyrosine phosphorylation of Stat3, which was abolished by the Jak2 inhibitor AG490.	Tyrosine	65-73	signal transducer and activator of transcription 3	Mus musculus	93-98
14729671-6	2004	Treatment of cultured C2C12 myotubes with ephrin-A1 also induced tyrosine phosphorylation of Stat3, which was abolished by the Jak2 inhibitor AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	142-147	signal transducer and activator of transcription 3	Mus musculus	93-98
15059889-7	2004	Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 3	Mus musculus	154-159
15059889-8	2004	Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3.	Tetradecanoylphorbol Acetate	48-51	signal transducer and activator of transcription 3	Mus musculus	139-144
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Tetradecanoylphorbol Acetate	127-163	signal transducer and activator of transcription 3	Mus musculus	7-12
15059889-9	2004	Finally, Stat3 deficiency in mouse epidermis significantly reduced the proliferative response after TPA treatment.	Tetradecanoylphorbol Acetate	100-103	signal transducer and activator of transcription 3	Mus musculus	9-14
15059889-2	2004	Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin.	Okadaic Acid	171-183	signal transducer and activator of transcription 3	Mus musculus	7-12
14985304-5	2004	Growth factor-induced proliferation of lens cells is inhibited by AG-490, a specific inhibitor of JAK2/STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	66-72	signal transducer and activator of transcription 3	Mus musculus	103-108
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	7,12-dimethylbenz	138-155	signal transducer and activator of transcription 3	Mus musculus	20-25
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	anthracene	158-168	signal transducer and activator of transcription 3	Mus musculus	20-25
15059889-3	2004	In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter.	Tetradecanoylphorbol Acetate	186-189	signal transducer and activator of transcription 3	Mus musculus	20-25
15059889-5	2004	In primary cultures of mouse keratinocytes, addition of exogenous EGF led to activation of Stat3 as shown by an elevation in tyrosine phosphorylation and nuclear translocation.	Tyrosine	125-133	signal transducer and activator of transcription 3	Mus musculus	91-96
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	123-128	signal transducer and activator of transcription 3	Mus musculus	0-6
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	151-158	signal transducer and activator of transcription 3	Mus musculus	0-6
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	Vitamin E	187-196	signal transducer and activator of transcription 3	Mus musculus	0-6
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	3-aminodiphenyleneiodium	226-229	signal transducer and activator of transcription 3	Mus musculus	0-6
15023522-7	2004	STAT-3 and ERK1/2 phosphorylation as well as NF-kappaB activation were inhibited by pretreatment with the Jak-2 antagonist AG490, the ERK1/2 inhibitor PD98059, the free radical scavenger vitamin E, the NADPH-oxidase inhibitor DPI, as well as by LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	245-253	signal transducer and activator of transcription 3	Mus musculus	0-6
15026546-5	2004	In this context, the representative peptidomimetic ISS 610 with 4-cyanobenzoate substitution inhibits constitutive Stat3 activity in Src-transformed mouse fibroblasts and human breast and lung carcinoma cells.	4-cyanobenzoic acid	64-79	signal transducer and activator of transcription 3	Mus musculus	115-120
15086564-7	2004	rmIL-6 treatment of fibroblast, however, induced a rapid and sustained phosphorylation of STAT3 protein.	rmil-6	0-6	signal transducer and activator of transcription 3	Mus musculus	90-95
16212920-0	2004	Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3.	Carbon Tetrachloride	92-112	signal transducer and activator of transcription 3	Mus musculus	163-168
14603524-5	2004	We demonstrate that RA-induced differentiation of CCE ES cells is associated with (1) downregulation of the LIF receptor (LIFR); (2) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein (Stat3); and (3) increased activation of extracellular regulated kinase (Erk1/2).	Tretinoin	20-22	signal transducer and activator of transcription 3	Mus musculus	171-221
14603524-5	2004	We demonstrate that RA-induced differentiation of CCE ES cells is associated with (1) downregulation of the LIF receptor (LIFR); (2) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein (Stat3); and (3) increased activation of extracellular regulated kinase (Erk1/2).	Tretinoin	20-22	signal transducer and activator of transcription 3	Mus musculus	231-236
14617800-6	2004	Phosphorylation of the transcription factor STAT3 on Ser-727, mediated by the extracellular signal-regulated kinase MAP kinase pathway, may contribute to the decrease in both Bax and Fas expression in p38 alpha-/- cells.	Serine	53-56	signal transducer and activator of transcription 3	Mus musculus	44-49
14716305-0	2004	Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.	Carbohydrates	64-76	signal transducer and activator of transcription 3	Mus musculus	8-14
14716305-6	2004	Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.	Glucose	54-61	signal transducer and activator of transcription 3	Mus musculus	8-14
14737107-3	2004	However, although constitutively activated STAT3 mutant (STAT3C) leads to cellular transformation, its transformation potential such as colony-forming activity in soft-agar is much weaker than that of v-src.	Agar	168-172	signal transducer and activator of transcription 3	Mus musculus	43-48
14697342-7	2004	The combined treatment of dexamethasone and oncostatin M (OSM) enhanced the expression of the acute phase proteins in B13 cells and the mechanism of the up-regulation by the cytokine is probably mediated by phosphorylation of STAT3 and STAT1.	Dexamethasone	26-39	signal transducer and activator of transcription 3	Mus musculus	226-231
14702106-5	2004	However, exposure of adult Stat-3-deleted mice to 95% oxygen caused a more rapidly progressive lung injury associated with alveolar capillary leak and acute respiratory distress.	Oxygen	54-60	signal transducer and activator of transcription 3	Mus musculus	27-33
14702106-9	2004	Expression of Stat-3 in respiratory epithelial cells is not required for lung formation, but plays a critical role in maintenance of surfactant homeostasis and lung function during oxygen injury.	Oxygen	181-187	signal transducer and activator of transcription 3	Mus musculus	14-20
14673173-0	2004	Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.	Serine	88-94	signal transducer and activator of transcription 3	Mus musculus	18-23
14673173-0	2004	Essential role of STAT3 in postnatal survival and growth revealed by mice lacking STAT3 serine 727 phosphorylation.	Serine	88-94	signal transducer and activator of transcription 3	Mus musculus	82-87
14673173-1	2004	A large number of extracellular polypeptides bound to their cognate receptors activate the transcription factor STAT3 by phosphorylation of tyrosine 705.	Tyrosine	140-148	signal transducer and activator of transcription 3	Mus musculus	112-117
14673173-9	2004	The lethality and decreased growth were accompanied by altered insulin-like growth factor 1 (IGF-1) levels in serum, establishing a role for the STAT3 serine phosphorylation acting through IGF-1 in embryonic and perinatal growth.	Serine	151-157	signal transducer and activator of transcription 3	Mus musculus	145-150
15249728-3	2004	Tyrosine phosphorylation of the signal transducer and activator of transcription (STAT)3 and STAT1, the STAT-dependent suppressor of cytokine signaling (SOCS)-3 promoter activity, SOCS-3 gene expression, STAT-dependent POMC promoter activity and adrenocorticotropic hormone (ACTH) secretion were determined.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	32-88
14644624-12	2003	Acetaminophen-induced expression of phosphorylated STAT3, a key regulator of cytokine-induced hepatocyte proliferation, was also delayed in TNFR1-/- mice relative to WT.	Acetaminophen	0-13	signal transducer and activator of transcription 3	Mus musculus	51-56
14523036-0	2003	Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.	ammonium ferrous sulfate	23-26	signal transducer and activator of transcription 3	Mus musculus	0-5
14566054-5	2003	As measured by serial echocardiograms, mice with cardiac specific deletion of STAT3 are significantly more susceptible to cardiac injury after doxorubicin treatment than age-matched controls.	Doxorubicin	143-154	signal transducer and activator of transcription 3	Mus musculus	78-83
14523036-8	2003	These findings indicate that Stat3 activation protects against Fas-mediated liver injury by inhibiting caspase activities in redox-dependent and -independent mechanisms.	ammonium ferrous sulfate	63-66	signal transducer and activator of transcription 3	Mus musculus	29-34
12691915-9	2003	In the normal AGM cell culture, introduction of a dominant-negative form of STAT3 in which Y(705) was changed to phenylalanine suppressed the expansion of hematopoietic cell colonies.	Phenylalanine	113-126	signal transducer and activator of transcription 3	Mus musculus	76-81
12817006-5	2003	In this context the cytoplasmic SHP2/SOCS3 recruitment site of gp130 tyrosine 759 is shown to be important for the inhibitory effects of TNF-alpha, since mutation of this residue completely restores IL-6-stimulated activation of STAT3 and, consequently, of a STAT3-dependent promoter.	Tyrosine	69-77	signal transducer and activator of transcription 3	Mus musculus	229-234
12817006-5	2003	In this context the cytoplasmic SHP2/SOCS3 recruitment site of gp130 tyrosine 759 is shown to be important for the inhibitory effects of TNF-alpha, since mutation of this residue completely restores IL-6-stimulated activation of STAT3 and, consequently, of a STAT3-dependent promoter.	Tyrosine	69-77	signal transducer and activator of transcription 3	Mus musculus	259-264
12665506-0	2003	Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart.	Isoproterenol	43-56	signal transducer and activator of transcription 3	Mus musculus	73-78
12665506-1	2003	This study was aimed to determine whether beta-adrenergic receptor (beta-AR) stimulated by isoproterenol (ISO) activates signal transducers and activators of transcription (STAT) in mouse heart and, if so, to examine the underlying mechanism.	Isoproterenol	91-104	signal transducer and activator of transcription 3	Mus musculus	173-177
12665506-1	2003	This study was aimed to determine whether beta-adrenergic receptor (beta-AR) stimulated by isoproterenol (ISO) activates signal transducers and activators of transcription (STAT) in mouse heart and, if so, to examine the underlying mechanism.	Isoproterenol	106-109	signal transducer and activator of transcription 3	Mus musculus	173-177
12665506-2	2003	We found that treatment of adult male mice by ISO (15 mg/kg body weight, intraperitoneal) caused a delayed STAT3 activation (at 60-120 min), which was fully abolished by beta-AR antagonist, propranolol.	Isoproterenol	46-49	signal transducer and activator of transcription 3	Mus musculus	107-112
12665506-2	2003	We found that treatment of adult male mice by ISO (15 mg/kg body weight, intraperitoneal) caused a delayed STAT3 activation (at 60-120 min), which was fully abolished by beta-AR antagonist, propranolol.	Propranolol	190-201	signal transducer and activator of transcription 3	Mus musculus	107-112
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Isoproterenol	0-3	signal transducer and activator of transcription 3	Mus musculus	31-36
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Isoproterenol	0-3	signal transducer and activator of transcription 3	Mus musculus	164-169
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Amrinone	90-98	signal transducer and activator of transcription 3	Mus musculus	31-36
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Amrinone	90-98	signal transducer and activator of transcription 3	Mus musculus	164-169
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Cyclic AMP	116-120	signal transducer and activator of transcription 3	Mus musculus	31-36
12665506-3	2003	ISO-induced phosphorylation of STAT3 was markedly enhanced by phosphodiesterase inhibitor amrinone, indicating that cAMP is critically involved in beta-AR-mediated STAT3 activation.	Cyclic AMP	116-120	signal transducer and activator of transcription 3	Mus musculus	164-169
12637586-4	2003	In this study, we show that RET/PTC associates with signal transducer and activator of transcription 3 (STAT3) and activates it by the specific phosphorylation of the tyrosine 705 residue.	Tyrosine	167-175	signal transducer and activator of transcription 3	Mus musculus	52-102
12637586-4	2003	In this study, we show that RET/PTC associates with signal transducer and activator of transcription 3 (STAT3) and activates it by the specific phosphorylation of the tyrosine 705 residue.	Tyrosine	167-175	signal transducer and activator of transcription 3	Mus musculus	104-109
12637586-7	2003	In addition, RET/PTC-mediated cellular transformation and proliferation of transformed cells require tyrosine 705 phosphorylation of STAT3 in NIH3T3 cells.	Tyrosine	101-109	signal transducer and activator of transcription 3	Mus musculus	133-138
12748279-5	2003	GH-induced JAK2 phosphorylation was greater in knockout (KO) than in wild-type (WT) PTP-1B embryonic fibroblasts and resulted in increased tyrosine phosphorylation of STAT3 and STAT5, while overexpression of PTP-1B reduced the GH-mediated activation of the acid-labile subunit gene.	Tyrosine	139-147	signal transducer and activator of transcription 3	Mus musculus	167-172
14550774-3	2003	In CNTF(-/-) mouse mutants, activation of STAT3 signaling was delayed by 10-12 h. Application of CNTF to the transected nerve restored rapid STAT3 activation in CNTF-deficient animals, whereas application of colchicine suppressed STAT3 signaling in wildtype mice for at least 24 h. These results identify CNTF as an early retrograde signal in axotomized facial motoneurons by showing that CNTF released at the lesion site is responsible for the initial induction of STAT3 signaling.	Colchicine	208-218	signal transducer and activator of transcription 3	Mus musculus	42-47
12884300-6	2003	Further analysis showed that ME3738 induces IL-6 serum levels and activates STAT3 DNA binding and target gene transcription.	ME3738	29-35	signal transducer and activator of transcription 3	Mus musculus	76-81
12873986-6	2003	In this study, we demonstrated in stably transfected NIH-3T3 cells that activation of Stat3 by EGFR was eliminated by mutation of all five EGFR tyrosines to phenylalanine and that activation was restored with return of two of the mutated tyrosine sites, Y1068 and Y1086, to wild-type.	Tyrosine	144-153	signal transducer and activator of transcription 3	Mus musculus	86-91
12873986-6	2003	In this study, we demonstrated in stably transfected NIH-3T3 cells that activation of Stat3 by EGFR was eliminated by mutation of all five EGFR tyrosines to phenylalanine and that activation was restored with return of two of the mutated tyrosine sites, Y1068 and Y1086, to wild-type.	Phenylalanine	157-170	signal transducer and activator of transcription 3	Mus musculus	86-91
12873986-6	2003	In this study, we demonstrated in stably transfected NIH-3T3 cells that activation of Stat3 by EGFR was eliminated by mutation of all five EGFR tyrosines to phenylalanine and that activation was restored with return of two of the mutated tyrosine sites, Y1068 and Y1086, to wild-type.	Tyrosine	144-152	signal transducer and activator of transcription 3	Mus musculus	86-91
12684046-6	2003	Subsequently, STAT-3 translocated to the nucleus where serine 727 (S727) was phosphorylated, establishing a transcriptionally active STAT-3 transcription factor.	Serine	55-61	signal transducer and activator of transcription 3	Mus musculus	133-139
12540842-7	2003	In the STAP-2(-/-) hepatocytes, the interleukin-6-induced expression of acute-phase (AP) genes and the tyrosine-phosphorylation level of STAT3 were reduced specifically at the late phase (6-24 h) of the response.	Tyrosine	103-111	signal transducer and activator of transcription 3	Mus musculus	137-142
12591923-9	2003	STAT3 preferentially binds peptides with the motif phosphotyrosine-(basic or hydrophobic)-(proline or basic)-glutamine.	Phosphotyrosine	51-66	signal transducer and activator of transcription 3	Mus musculus	0-5
12591923-9	2003	STAT3 preferentially binds peptides with the motif phosphotyrosine-(basic or hydrophobic)-(proline or basic)-glutamine.	Proline	91-98	signal transducer and activator of transcription 3	Mus musculus	0-5
12591923-9	2003	STAT3 preferentially binds peptides with the motif phosphotyrosine-(basic or hydrophobic)-(proline or basic)-glutamine.	Glutamine	109-118	signal transducer and activator of transcription 3	Mus musculus	0-5
12406902-8	2003	At the biochemical level, SU5614 down-regulated the activity of the hyperphosphorylated FLT3 receptor and its downstream targets, signal transducer and activator of (STAT) 3, STAT5, and mitogen-activated protein kinase (MAPK), and the STAT5 target genes BCL-X(L) and p21.	SU 5614	26-32	signal transducer and activator of transcription 3	Mus musculus	130-173
12594516-3	2003	Tyr 1138 of LRb mediates activation of the transcription factor STAT3 during leptin action.	Tyrosine	0-3	signal transducer and activator of transcription 3	Mus musculus	64-69
12649187-2	2003	To discover disrupters of aberrant STAT3 signaling pathways as novel anticancer drugs, we developed a phosphotyrosine STAT3 cytoblot.	Phosphotyrosine	102-117	signal transducer and activator of transcription 3	Mus musculus	35-40
12649187-2	2003	To discover disrupters of aberrant STAT3 signaling pathways as novel anticancer drugs, we developed a phosphotyrosine STAT3 cytoblot.	Phosphotyrosine	102-117	signal transducer and activator of transcription 3	Mus musculus	118-123
12649187-4	2003	JSI-124 suppressed the levels of phosphotyrosine STAT3 in v-Src-transformed NIH 3T3 cells and human cancer cells potently (IC(50) value of 500 nM in the human lung adenocarcinoma A549) and rapidly (complete inhibition within 1-2 h).	Phosphotyrosine	33-48	signal transducer and activator of transcription 3	Mus musculus	49-54
12547723-15	2003	The ability of IL-6 to induce tyrosine phosphorylation of STAT3 was abolished in the LNCaP-IL-6+ subline.	Tyrosine	30-38	signal transducer and activator of transcription 3	Mus musculus	58-63
12436061-7	2002	CONCLUSIONS: EtOH amplifies G1 checkpoint mechanisms that are induced by oxidative stress and promotes hepatic accumulation of factors, including p38 MAPK, p21, and signal transducer and activator of transcription-3, that enhance cellular survival after oxidant exposure.	Ethanol	13-17	signal transducer and activator of transcription 3	Mus musculus	165-215
12649187-5	2003	The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription.	Phosphotyrosine	19-34	signal transducer and activator of transcription 3	Mus musculus	35-40
12649187-5	2003	The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription.	Phosphotyrosine	19-34	signal transducer and activator of transcription 3	Mus musculus	78-83
12649187-5	2003	The suppression of phosphotyrosine STAT3 levels resulted in the inhibition of STAT3 DNA binding and STAT3-mediated but not serum response element-mediated gene transcription.	Phosphotyrosine	19-34	signal transducer and activator of transcription 3	Mus musculus	78-83
12649187-7	2003	JSI-124 was highly selective for JAK/STAT3 and did not inhibit other oncogenic and tumor survival pathways such as those mediated by Akt, extracellular signal-regulated kinase 1/2, or c-Jun NH(2)-terminal kinase.	cucurbitacin I	0-7	signal transducer and activator of transcription 3	Mus musculus	37-42
12496442-5	2003	Cell signaling studies showed that murine OSM, LIF, IL-6, and CT-1 stimulated the tyrosine phosphorylation of STAT-3, suggesting STAT-3 activation is not sufficient for eotaxin induction in NIH 3T3 cells.	Tyrosine	82-90	signal transducer and activator of transcription 3	Mus musculus	110-116
12429573-14	2002	Moreover, IL-4, IL-10, GM-CSF and M-CSF elicited tyrosine phosphorylation of STAT3, STAT5 and/or STAT6 in macrophages were diminished by the presence of ATA.	Tyrosine	49-57	signal transducer and activator of transcription 3	Mus musculus	77-82
14708085-6	2003	The results showed that in scr -/- mice the effect of TCDD was less in the case of mRNA expression of PDGF(AA), STAT3, C/EPBbeta, NMT-1, and AP-2gamma in addition to c-src as compared to scr +/+ mice.	Polychlorinated Dibenzodioxins	54-58	signal transducer and activator of transcription 3	Mus musculus	112-117
12239166-0	2002	Heparin acts synergistically with interleukin-11 to induce STAT3 activation and in vitro osteoclast formation.	Heparin	0-7	signal transducer and activator of transcription 3	Mus musculus	59-64
12057007-6	2002	The direct interaction of STAT3 and NF-kappaB p65 was verified in vivo by co-immunoprecipitation and in vitro by pull-down assays with glutathione S-transferase-NF-kappaB p65 fusion protein and in vitro -translated STAT3alpha.	Glutathione	135-146	signal transducer and activator of transcription 3	Mus musculus	26-31
12239166-7	2002	Heparin was found to enhance both IL-11-induced STAT3-DNA complex formation and transactivation without altering either STAT3 (signal transducer and activator of transcription-3) tyrosine or serine phosphorylation.	Heparin	0-7	signal transducer and activator of transcription 3	Mus musculus	48-53
12481435-9	2002	In signaling studies, addition of stem cell factor (SCF) induced phosphorylation of ERK and Akt by WTKit, and ERK, Akt and STAT3 by V560GKit, which were all blocked by Imatinib.	Imatinib Mesylate	168-176	signal transducer and activator of transcription 3	Mus musculus	123-128
12297545-18	2002	Thus, Stat3 phosphorylation was studied in WT and alphaERKO samples and found to be induced following oil infusion in all samples.	Oils	102-105	signal transducer and activator of transcription 3	Mus musculus	6-11
12481435-10	2002	Imatinib also blocked the constitutive activation of Akt and STAT3 by V560GKit but had no affect on the constitutive activation of ERK, Akt, and STAT3 by D816VKit.	Imatinib Mesylate	0-8	signal transducer and activator of transcription 3	Mus musculus	61-66
12147685-7	2002	Activation of STAT3 in fetal hepatocytes of transgenic mice expressing the STAT3-estrogen receptor fusion protein by 4-hydroxytamoxifen resulted in the suppression of cyclin D1 and D2 expression.	hydroxytamoxifen	117-135	signal transducer and activator of transcription 3	Mus musculus	14-19
12147685-7	2002	Activation of STAT3 in fetal hepatocytes of transgenic mice expressing the STAT3-estrogen receptor fusion protein by 4-hydroxytamoxifen resulted in the suppression of cyclin D1 and D2 expression.	hydroxytamoxifen	117-135	signal transducer and activator of transcription 3	Mus musculus	75-80
12354677-5	2002	Stimulation of GT1-7 cells by leptin caused tyrosine phosphorylation of endogenous STAT3 and activation of a STAT-dependent luciferase reporter gene.	Tyrosine	44-52	signal transducer and activator of transcription 3	Mus musculus	83-88
12354677-6	2002	Over-expression of PTP1B in GT1-7 cells resulted in a dose-dependent decrease in endogenous JAK2 and STAT3 tyrosine phosphorylation compared with cells transfected with lepR alone.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	101-106
12107100-7	2002	Moreover, a striking inverse correlation was noted between hepatocyte nuclear accumulation of phospho-STAT-3 and DNA synthesis (as assessed by bromodeoxyuridine labeling), as well as cyclin D1 mRNA induction and protein expression.	Bromodeoxyuridine	143-160	signal transducer and activator of transcription 3	Mus musculus	102-108
12193580-1	2002	The transcription factor Stat3 is activated through tyrosine phosphorylation by many cytokines and is a fundamental mediator of their signals.	Tyrosine	52-60	signal transducer and activator of transcription 3	Mus musculus	25-30
12193580-2	2002	In the mammary gland, Stat3 activity increases sharply shortly after weaning, and involution is delayed in mice, that contain a mutant Stat3 lacking 33 amino acids including the key tyrosine residue.	Tyrosine	182-190	signal transducer and activator of transcription 3	Mus musculus	22-27
12193580-2	2002	In the mammary gland, Stat3 activity increases sharply shortly after weaning, and involution is delayed in mice, that contain a mutant Stat3 lacking 33 amino acids including the key tyrosine residue.	Tyrosine	182-190	signal transducer and activator of transcription 3	Mus musculus	135-140
12349947-4	2002	The MCP-1-induced tyrosine phosphorylation of cellular proteins involved the phosphorylation of non-receptor tyrosine kinases Lyn, JAK2, cytoskeletal binding protein paxillin and downstream transcription factors STAT3 and STAT5.	Tyrosine	18-26	signal transducer and activator of transcription 3	Mus musculus	212-217
12055259-8	2002	Finally, we show that forced expression of SOCS-3 significantly suppresses the ability of IL-10 to trigger tyrosine phosphorylation of STAT3.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	135-140
12055272-7	2002	In vitro treatment of activated T cells with curcumin inhibited IL-12-induced tyrosine phosphorylation of Janus kinase 2, tyrosine kinase 2, and STAT3 and STAT4 transcription factors.	Curcumin	45-53	signal transducer and activator of transcription 3	Mus musculus	145-150
12055606-11	2002	Phosphorylation of signal transducer and activator of transcription 3 and induction of cyclooxygenase 2 were absent in the colon of DSS-fed ob/ob mice.	Dextran Sulfate	132-135	signal transducer and activator of transcription 3	Mus musculus	19-69
11830592-7	2002	IL6RIL6 stimulates the interleukin-6 family cytokine receptor gp130, leading to the rapid phosphorylation of Stat3 on tyrosine 705.	Tyrosine	118-126	signal transducer and activator of transcription 3	Mus musculus	109-114
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	72-77
11858938-8	2002	AG490 inhibited the LIF-induced STAT3 phosphorylation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	32-37
11970898-6	2002	Compared to wild-type littermates, PTP1B(-/-) mice have decreased leptin/body fat ratios, leptin hypersensitivity, and enhanced leptin-induced hypothalamic Stat3 tyrosyl phosphorylation.	cyclo(tyrosyl-tyrosyl)	162-169	signal transducer and activator of transcription 3	Mus musculus	156-161
11799110-0	2002	The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.	ros	76-79	signal transducer and activator of transcription 3	Mus musculus	67-72
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	79-84
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	72-77
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	175-183	signal transducer and activator of transcription 3	Mus musculus	79-84
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	72-77
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	79-84
11964566-11	2002	Ethanol consumption also decreased hypothalamic expression of STAT3, a protein associated with leptin receptor activation in this region of the brain.	Ethanol	0-7	signal transducer and activator of transcription 3	Mus musculus	62-67
11698287-2	2001	It has recently been reported that a cytosolic isoform of PTPepsilon (PTPepsilonC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)- and leukemia inhibitory factor-induced activation of Janus kinases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signaling.	Tyrosine	262-270	signal transducer and activator of transcription 3	Mus musculus	256-261
11751994-8	2002	Transfection of BaF3 cells with NPM/ALK resulted in tyrosine phosphorylation of STAT3.	Tyrosine	52-60	signal transducer and activator of transcription 3	Mus musculus	80-85
11739197-5	2001	In this study, cloning, sequencing, and splicing analysis of the human and murine STAT3 genes revealed a highly conserved 5" donor site for generation of both alpha and beta mRNA and distinct branch-point sequences, polypyrimidine tracts, and 3" acceptor sites (ASs) for each.	polypyrimidine	216-230	signal transducer and activator of transcription 3	Mus musculus	82-87
11698287-2	2001	It has recently been reported that a cytosolic isoform of PTPepsilon (PTPepsilonC) when over-expressed in murine M1 myeloid cells inhibits interleukin-6 (IL-6)- and leukemia inhibitory factor-induced activation of Janus kinases (JAKs), thereby suppressing STAT3 tyrosine phosphorylation and STAT3 signaling.	Tyrosine	262-270	signal transducer and activator of transcription 3	Mus musculus	291-296
11698287-7	2001	In terms of specificity to cytokines, over-expressed PTPepsilonC also inhibits IL-10-induced tyrosine phosphorylation of STAT3 in M1 cells, whereas PTPepsilonC does not affect either interferon-beta- and interferon-gamma-induced tyrosine phosphorylation of STATs or expression of STAT transcriptional targets.	Tyrosine	93-101	signal transducer and activator of transcription 3	Mus musculus	121-126
11522790-2	2001	We have found that transgenic (Tg) mice expressing a mutant JAB (F59D-JAB) exhibited a more potent STAT3 activation and a more severe colitis than did wild-type littermates after treatment with dextran sulfate sodium.	Dextran Sulfate	194-216	signal transducer and activator of transcription 3	Mus musculus	99-104
11606024-9	2001	Tyrphostin is an inhibitor of Jak2, Jak3, STATI, STAT3 and STAT5.	Tyrphostins	0-10	signal transducer and activator of transcription 3	Mus musculus	49-54
11533249-2	2001	In certain IL-6-responsive cell lines, the stat3 gene is autoregulated by STAT3 through a composite IL-6 response element in its promoter that contains a STAT3-binding element (SBE) and a cyclic AMP-responsive element.	Cyclic AMP	188-198	signal transducer and activator of transcription 3	Mus musculus	43-48
11536047-3	2001	MEN2A-RET induces both Tyr705 and Ser727 phosphorylation of STAT3, and STAT3 serine phosphorylation is required for its maximal transcriptional activity.	Serine	77-83	signal transducer and activator of transcription 3	Mus musculus	71-76
11533249-2	2001	In certain IL-6-responsive cell lines, the stat3 gene is autoregulated by STAT3 through a composite IL-6 response element in its promoter that contains a STAT3-binding element (SBE) and a cyclic AMP-responsive element.	Cyclic AMP	188-198	signal transducer and activator of transcription 3	Mus musculus	74-79
11412337-5	2001	GABA neurones in the ventromedial arcuate nucleus were shown to contain leptin receptor immunoreactivity, as revealed using an antiserum generated to a sequence common to all isoforms of the leptin receptor (Ob-R), as well as an antiserum generated to the carboxy-terminal end of the long leptin receptor (Ob-Rb), and immunoreactivity for the leptin-induced signal transduction molecule STAT3.	gamma-Aminobutyric Acid	0-4	signal transducer and activator of transcription 3	Mus musculus	387-392
11481471-7	2001	Pretreatment with the JAK inhibitor AG-490 20 min before the six occlusion/reperfusion cycles blocked the enhanced tyrosine phosphorylation of JAK1 and JAK2 and the increased tyrosine phosphorylation, nuclear translocation, and enhanced DNA-binding activity of STAT1 and STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	36-42	signal transducer and activator of transcription 3	Mus musculus	271-276
11404481-9	2001	Moreover, inhibition of Src family kinases with the pharmacologic agent, SU6656, blocks Stat3 activation by PDGF.	SU 6656	73-79	signal transducer and activator of transcription 3	Mus musculus	88-93
11278899-2	2001	Treatment of platelets with thrombin induced tyrosine phosphorylation of the JAK3 target substrates STAT1 and STAT3.	Tyrosine	45-53	signal transducer and activator of transcription 3	Mus musculus	110-115
11181699-6	2001	Development of colitis as well as STAT3 activation was significantly reduced in IL-6-deficient mice treated with DSS, suggesting that STAT3 plays an important role in the perpetuation of colitis.	Dextran Sulfate	113-116	signal transducer and activator of transcription 3	Mus musculus	34-39
11524388-1	2001	BACKGROUND: Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage.	Doxorubicin	133-144	signal transducer and activator of transcription 3	Mus musculus	57-107
11524388-1	2001	BACKGROUND: Mice with cardiac-specific overexpression of signal transducer and activator of transcription 3 (STAT3) are resistant to doxorubicin-induced damage.	Doxorubicin	133-144	signal transducer and activator of transcription 3	Mus musculus	109-114
11181699-6	2001	Development of colitis as well as STAT3 activation was significantly reduced in IL-6-deficient mice treated with DSS, suggesting that STAT3 plays an important role in the perpetuation of colitis.	Dextran Sulfate	113-116	signal transducer and activator of transcription 3	Mus musculus	134-139
11181699-9	2001	DSS induced stronger STAT3 activation and more severe colitis in F59D-JAB transgenic mice than in their wild-type littermates.	Dextran Sulfate	0-3	signal transducer and activator of transcription 3	Mus musculus	21-26
11180132-0	2001	Lymphokine dependence of STAT3 activation produced by surface immunoglobulin cross-linking and by phorbol ester plus calcium ionophore treatment in B cells.	Phorbol Esters	98-111	signal transducer and activator of transcription 3	Mus musculus	25-30
11180132-0	2001	Lymphokine dependence of STAT3 activation produced by surface immunoglobulin cross-linking and by phorbol ester plus calcium ionophore treatment in B cells.	Calcium	117-124	signal transducer and activator of transcription 3	Mus musculus	25-30
11180132-5	2001	In contrast, IL-10 alone appeared to account for STAT3 activation resulting from B cell stimulation with phorbol ester and calcium ionophore.	Phorbol Esters	105-118	signal transducer and activator of transcription 3	Mus musculus	49-54
11180132-5	2001	In contrast, IL-10 alone appeared to account for STAT3 activation resulting from B cell stimulation with phorbol ester and calcium ionophore.	Calcium	123-130	signal transducer and activator of transcription 3	Mus musculus	49-54
11881154-0	2001	[H2O2-induced activation of transcription factors STAT1 and STAT3: the role of EGF receptor and tyrosine kinase JAK2].	Hydrogen Peroxide	1-5	signal transducer and activator of transcription 3	Mus musculus	60-65
11881154-2	2001	Here, we demonstrate tyrosine phosphorylation of EGF receptor, STAT3, and, to a lesser extent, STAT1 upon H2O2 treatment of HER14 cells (NIH3T3 fibroblasts transfected with full-length EGF receptor).	Hydrogen Peroxide	106-110	signal transducer and activator of transcription 3	Mus musculus	63-68
11881154-5	2001	STAT3 and STAT1 activation in HER14 cells was demonstrated to depend on EGF receptor kinase activity, rather than JAK2 activity, while in both K721A and CD126 cells (NIH3T3 transfected with kinase-dead EGF receptor, and EGF receptor lacking major autophosphorylation sites, respectively) STAT1 and STAT3 tyrosine phosphorylation requires JAK2 kinase activity.	Tyrosine	304-312	signal transducer and activator of transcription 3	Mus musculus	0-5
11881154-6	2001	Furthermore, STAT3 is constitutively phosphorylated in K721A and CD126 cells, and STAT1 H2O2-stimulated activation in these cells is much more prominent than in HER14.	Hydrogen Peroxide	88-92	signal transducer and activator of transcription 3	Mus musculus	13-18
11049111-10	2000	Similarly, STAT3 expression was decreased in T lymphocytes following trauma-hemorrhage and the expression was restored by flutamide pre-treatment.	Flutamide	122-131	signal transducer and activator of transcription 3	Mus musculus	11-16
11087819-6	2000	It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively.	Tetradecanoylphorbol Acetate	174-205	signal transducer and activator of transcription 3	Mus musculus	60-65
11087819-6	2000	It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively.	Tetradecanoylphorbol Acetate	207-210	signal transducer and activator of transcription 3	Mus musculus	60-65
11087819-9	2000	Both Stat3-dependent and -independent migration of keratinocytes was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin.	Wortmannin	128-138	signal transducer and activator of transcription 3	Mus musculus	5-10
11064148-2	2000	Immunoblot experiments showed that tyrosine phosphorylation of Stat3 increased in total cellular extracts and that the phosphorylated protein translocated into the nucleus upon leptin treatment.	Tyrosine	35-43	signal transducer and activator of transcription 3	Mus musculus	63-68
11023666-4	2000	Intravenous administration of leukaemia inhibitory factor (LIF) induced tyrosine phosphorylation of STAT3 and ERK 1/2 and expression of c-fos and beta-MHC mRNAs in wild-type littermates" (WT) hearts.	Tyrosine	72-80	signal transducer and activator of transcription 3	Mus musculus	100-105
10960443-11	2000	Strong activation of Stat3 resulted in a delay and inhibition of hepatocyte proliferation as measured by 5-bromo-2"-deoxyuridine (BrdU) staining and Cyclin A and E expression.	Bromodeoxyuridine	105-128	signal transducer and activator of transcription 3	Mus musculus	21-26
10960443-11	2000	Strong activation of Stat3 resulted in a delay and inhibition of hepatocyte proliferation as measured by 5-bromo-2"-deoxyuridine (BrdU) staining and Cyclin A and E expression.	Bromodeoxyuridine	130-134	signal transducer and activator of transcription 3	Mus musculus	21-26
10858439-4	2000	We generated an erythropoietin receptor (EpoR) isoform (ER343/401-S3) that activates Stat3 rather than Stat5 by substituting the Stat3 binding/activation sequence motif from gp130 for the sequences surrounding tyrosines 343 and 401 in the receptor cytoplasmic region.	Tyrosine	210-219	signal transducer and activator of transcription 3	Mus musculus	85-90
11021752-6	2000	Immunoblot analyses showed that JAK 2, STAT 3, STAT 5a, STAT 5b and CBL were tyrosine-phosphorylated in TEL-FLT3 expressing Ba/F3 cells in the absence of IL-3.	Tyrosine	77-85	signal transducer and activator of transcription 3	Mus musculus	39-45
10823829-7	2000	The phosphorylated Stat1 and Stat3 proteins are functionally activated, as measured by their abilities to specifically bind DNA oligonucleotide probes.	Oligonucleotides	128-143	signal transducer and activator of transcription 3	Mus musculus	29-34
10523632-8	1999	Tyrosine phosphorylation of Stat3 and Stat5A in bone marrow-derived macrophages was dramatically reduced in response to GM-CSF but not to IL-3 or IL-6.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	28-33
10823829-1	2000	Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors that transduce signals from the cell membrane to the nucleus upon activation by tyrosine phosphorylation.	Tyrosine	184-192	signal transducer and activator of transcription 3	Mus musculus	52-57
10823829-6	2000	Our results show that Src can tyrosine-phosphorylate Stat1 and Stat3 but not Stat5 in this system.	Tyrosine	30-38	signal transducer and activator of transcription 3	Mus musculus	63-68
10896772-1	2000	STAT3 is constitutively phosphorylated on tyrosine(705) in self-renewing, CD5(+) murine B-1 lymphocytes.	Tyrosine	42-50	signal transducer and activator of transcription 3	Mus musculus	0-5
10896772-2	2000	Nuclear extracts from untreated primary B-1 or CD5(+) BCL(1) B lymphoma cells were found to contain immunoreactive STAT3 protein that binds to a sis-inducible element present in the promoter of the p21(waf1/cip1) tumor suppressor gene and is constitutively phosphorylated on serine(727).	Serine	275-281	signal transducer and activator of transcription 3	Mus musculus	115-120
10896772-3	2000	To determine the functional significance of constitutive STAT3 activation in B lymphoma cells, a specific STAT3 antisense oligonucleotide was developed and used to examine basal BCL(1) cell growth and IgM production.	Oligonucleotides	122-137	signal transducer and activator of transcription 3	Mus musculus	106-111
10896772-5	2000	Cell cycle analysis showed a block in progression through G1 in BCL(1) cells treated with the STAT3 antisense oligonucleotide.	Oligonucleotides	110-125	signal transducer and activator of transcription 3	Mus musculus	94-99
10799542-4	2000	By using this system, we confirm that two tyrosine residues in the intracellular domain of murine LRb become phosphorylated to mediate LRb signaling; Tyr(985) controls the tyrosine phosphorylation of SHP-2, and Tyr(1138) controls STAT3 activation.	Tyrosine	150-153	signal transducer and activator of transcription 3	Mus musculus	230-235
10799542-8	2000	In contrast, SOCS3 mRNA accumulation requires Tyr(1138)-mediated STAT3 activation.	Tyrosine	46-49	signal transducer and activator of transcription 3	Mus musculus	65-70
10799542-9	2000	Thus, the two LRb tyrosine residues that are phosphorylated during receptor activation mediate distinct signaling pathways as follows: SHP-2 binding to Tyr(985) positively regulates the ERK --> c-fos pathway, and STAT3 binding to Tyr(1138) mediates the inhibitory SOCS3 pathway.	Tyrosine	18-26	signal transducer and activator of transcription 3	Mus musculus	216-221
10618415-0	2000	Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.	Doxorubicin	138-149	signal transducer and activator of transcription 3	Mus musculus	0-50
10618415-8	2000	Although the expression of these mRNAs was elevated in STAT3-TG hearts before Dox treatment, no additional increase was observed after the treatment.	Doxorubicin	78-81	signal transducer and activator of transcription 3	Mus musculus	55-60
10618415-10	2000	These results provide direct evidence that STAT3 transduces not only a hypertrophic signal but also a protective signal against Dox-induced cardiomyopathy by inhibiting reduction of cardiac contractile genes and inducing cardiac protective factors.	Doxorubicin	128-131	signal transducer and activator of transcription 3	Mus musculus	43-48
11920194-3	2000	The splice variant STAT3beta, that lacks a C-terminal serine residue implicated in the transcriptional activity of STAT3, has been shown to inhibit STAT3-mediated transcription in certain situations.	Serine	54-60	signal transducer and activator of transcription 3	Mus musculus	19-24
11920194-3	2000	The splice variant STAT3beta, that lacks a C-terminal serine residue implicated in the transcriptional activity of STAT3, has been shown to inhibit STAT3-mediated transcription in certain situations.	Serine	54-60	signal transducer and activator of transcription 3	Mus musculus	115-120
10597233-6	1999	We found that tyrosine phosphorylation of STAT3, also activated by CSF-1R/v-fms, was inhibited in alpha i2-G204A/v-fms cells; in addition, expression of an 85 kDa, C-terminal truncated form of STAT3 (STAT3 delta) was constitutively increased.	Tyrosine	14-22	signal transducer and activator of transcription 3	Mus musculus	42-47
10597233-6	1999	We found that tyrosine phosphorylation of STAT3, also activated by CSF-1R/v-fms, was inhibited in alpha i2-G204A/v-fms cells; in addition, expression of an 85 kDa, C-terminal truncated form of STAT3 (STAT3 delta) was constitutively increased.	Tyrosine	14-22	signal transducer and activator of transcription 3	Mus musculus	193-198
10597233-6	1999	We found that tyrosine phosphorylation of STAT3, also activated by CSF-1R/v-fms, was inhibited in alpha i2-G204A/v-fms cells; in addition, expression of an 85 kDa, C-terminal truncated form of STAT3 (STAT3 delta) was constitutively increased.	Tyrosine	14-22	signal transducer and activator of transcription 3	Mus musculus	193-198
10597233-7	1999	Both the inhibition of v-fms-induced STAT3 tyrosine phosphorylation and the increased expression of STAT3 delta were reproduced by transfecting a dominant negative mutant of Src.	Tyrosine	43-51	signal transducer and activator of transcription 3	Mus musculus	37-42
10918585-5	2000	The ability of tyrosine-to-phenylalanine substitution mutants of the G-CSF receptor to activate STAT3 strongly correlated with their capacity to induce p27 expression and their ability to mediate differentiation and survival, suggesting a causal relationship between STAT3 activation, p27 expression and the observed cellular responses.	Tyrosine	15-23	signal transducer and activator of transcription 3	Mus musculus	96-101
10918585-5	2000	The ability of tyrosine-to-phenylalanine substitution mutants of the G-CSF receptor to activate STAT3 strongly correlated with their capacity to induce p27 expression and their ability to mediate differentiation and survival, suggesting a causal relationship between STAT3 activation, p27 expression and the observed cellular responses.	Tyrosine	15-23	signal transducer and activator of transcription 3	Mus musculus	267-272
10918585-5	2000	The ability of tyrosine-to-phenylalanine substitution mutants of the G-CSF receptor to activate STAT3 strongly correlated with their capacity to induce p27 expression and their ability to mediate differentiation and survival, suggesting a causal relationship between STAT3 activation, p27 expression and the observed cellular responses.	Phenylalanine	27-40	signal transducer and activator of transcription 3	Mus musculus	96-101
10918585-5	2000	The ability of tyrosine-to-phenylalanine substitution mutants of the G-CSF receptor to activate STAT3 strongly correlated with their capacity to induce p27 expression and their ability to mediate differentiation and survival, suggesting a causal relationship between STAT3 activation, p27 expression and the observed cellular responses.	Phenylalanine	27-40	signal transducer and activator of transcription 3	Mus musculus	267-272
10779764-6	2000	An inducibly active Stat3 (coumermycin-dimerizable Stat3-Gyrase B), which suppresses J774 cell proliferation, also induced p19INK4D expression.	coumermycin	27-38	signal transducer and activator of transcription 3	Mus musculus	20-25
10779764-6	2000	An inducibly active Stat3 (coumermycin-dimerizable Stat3-Gyrase B), which suppresses J774 cell proliferation, also induced p19INK4D expression.	coumermycin	27-38	signal transducer and activator of transcription 3	Mus musculus	51-65
11042511-10	2000	Two membrane-distal tyrosines on the YXXQ motif of LIF-R are critical not only for STAT3 activation but also for growth arrest and macrophage differentiation of WEHI-3B D+ cells.	Tyrosine	20-29	signal transducer and activator of transcription 3	Mus musculus	83-88
10484075-3	1999	Activation of STAT1 and STAT3 was observed distinctly 4 hr after DMXAA and FAA stimulation.	vadimezan	65-70	signal transducer and activator of transcription 3	Mus musculus	24-29
10464327-3	1999	By introduction of point mutations in amino acids surrounding this tyrosine, we obtained receptors that activated either STAT5 alone or both STAT1 and STAT3, thus providing us with the possibility to study the respective roles of these factors in the biological activities of IL-9.	Tyrosine	67-75	signal transducer and activator of transcription 3	Mus musculus	151-156
10428964-5	1999	Mutational analysis of the cytoplasmic domain of gp130 revealed that the tyrosine residue of gp130 responsible for STAT3 activation is necessary for self-renewal of ES cells, while that required for SHP2 and MAP kinase activation was dispensable.	Tyrosine	73-81	signal transducer and activator of transcription 3	Mus musculus	115-120
10428964-7	1999	This construction (STAT3ER) induced expression of junB (one of the targets of STAT3) in ES cells in the presence of the synthetic ligand 4-hydroxytamoxifen (4HT), thereby indicating that STAT3ER is a conditionally active form.	hydroxytamoxifen	137-155	signal transducer and activator of transcription 3	Mus musculus	19-24
10428964-7	1999	This construction (STAT3ER) induced expression of junB (one of the targets of STAT3) in ES cells in the presence of the synthetic ligand 4-hydroxytamoxifen (4HT), thereby indicating that STAT3ER is a conditionally active form.	hydroxytamoxifen	137-155	signal transducer and activator of transcription 3	Mus musculus	78-83
10428964-7	1999	This construction (STAT3ER) induced expression of junB (one of the targets of STAT3) in ES cells in the presence of the synthetic ligand 4-hydroxytamoxifen (4HT), thereby indicating that STAT3ER is a conditionally active form.	4'-hydroxytamoxifen	157-160	signal transducer and activator of transcription 3	Mus musculus	19-24
10428964-7	1999	This construction (STAT3ER) induced expression of junB (one of the targets of STAT3) in ES cells in the presence of the synthetic ligand 4-hydroxytamoxifen (4HT), thereby indicating that STAT3ER is a conditionally active form.	4'-hydroxytamoxifen	157-160	signal transducer and activator of transcription 3	Mus musculus	78-83
10428964-8	1999	ES cells transfected with STAT3ER cultured in the presence of 4HT maintained an undifferentiated state.	4'-hydroxytamoxifen	62-65	signal transducer and activator of transcription 3	Mus musculus	26-31
9582023-1	1998	Interaction of IL-3 with its receptor is known to activate STAT-3 via phosphorylation of Tyrosine 701, which facilitates its dimerization and translocation to the nucleus, leading to the transcription of its target genes.	Tyrosine	89-97	signal transducer and activator of transcription 3	Mus musculus	59-65
10383440-0	1999	STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone.	Calcitriol	211-235	signal transducer and activator of transcription 3	Mus musculus	0-5
10361134-6	1999	TEL-Jak2 activation resulted in the constitutive tyrosine phosphorylation of Stat1, Stat3, and Stat5 as determined by detection of phosphorylation using activation-specific antibodies and by binding of each protein to a preferential GAS sequence in electrophoretic mobility shift assays.	Tyrosine	49-57	signal transducer and activator of transcription 3	Mus musculus	84-89
10347215-7	1999	Structure-function analysis of the intracellular domain of the IL-10 receptor alpha chain showed that whereas two redundant Stat3 recruitment sites (427YQKQ430 and 477YLKQ480) were required for all IL-10-dependent effects on either B cells or macrophages, expression of IL-10-dependent anti-inflammatory function required the presence on the intracellular domain of the IL-10 receptor of a carboxyl-terminal sequence containing at least one functionally critical serine.	Serine	463-469	signal transducer and activator of transcription 3	Mus musculus	124-129
10329697-7	1999	Analysis of signaling pathways downstream of these tyrosines suggested a positive role for STAT3 activation in both differentiation and survival signaling, whereas SHP-2, Grb2 and Shc appear important for proliferation signaling.	Tyrosine	51-60	signal transducer and activator of transcription 3	Mus musculus	91-96
10229872-6	1999	Inhibition of either Jak-2 or Tyk-2 leads to a decrease in the IL-12-induced tyrosine phosphorylation of Stat3, but not of Stat4, protein.	Tyrosine	77-85	signal transducer and activator of transcription 3	Mus musculus	105-110
9854025-5	1999	Electrophoretic mobility-shift assays using oligonucleotides from footprinted MT-I promoter regions showed that injection of LPS resulted in a rapid increase in the specific, high-affinity, in vitro binding of STAT1 and STAT3 to a binding site at -297 bp (TTCTCGTAA).	Oligonucleotides	44-60	signal transducer and activator of transcription 3	Mus musculus	220-225
9864141-3	1999	Activation of both Stat3 and Stat3beta requires the distal cytoplasmic domain of the G-CSFR, which contains four Tyr at positions 704, 729, 744, and 764.	Tyrosine	113-116	signal transducer and activator of transcription 3	Mus musculus	19-24
9864141-4	1999	The studies reported here were undertaken to determine which, if any, of these tyrosine residues participated in Stat3/beta recruitment and activation.	Tyrosine	79-87	signal transducer and activator of transcription 3	Mus musculus	113-118
9864141-9	1999	Y744 is followed at the +3 position by Cys (C); YXXC, represents a novel motif implicated in the recruitment and activation of Stat3.	Cysteine	39-42	signal transducer and activator of transcription 3	Mus musculus	127-132
9566874-2	1998	Previous studies have demonstrated that one STAT family member, Stat3, possesses constitutively elevated tyrosine phosphorylation and DNA-binding activity in fibroblasts stably transformed by the Src oncoprotein.	Tyrosine	105-113	signal transducer and activator of transcription 3	Mus musculus	64-69
10196143-4	1999	We show that these mutants act in a dominant negative manner by blocking endogenous STAT3 tyrosine phosphorylation or STAT3 DNA binding.	Tyrosine	90-98	signal transducer and activator of transcription 3	Mus musculus	84-89
10196143-6	1999	However, wild-type or dominant negative STAT3-overexpressing clones showed comparable (4-fold) POMC induction after treatment with cyclic adenosine monophosphate (cAMP), an alternate inducer of POMC transcription, indicating the STAT3 specificity for LIF signaling.	Cyclic AMP	131-161	signal transducer and activator of transcription 3	Mus musculus	40-45
10196143-6	1999	However, wild-type or dominant negative STAT3-overexpressing clones showed comparable (4-fold) POMC induction after treatment with cyclic adenosine monophosphate (cAMP), an alternate inducer of POMC transcription, indicating the STAT3 specificity for LIF signaling.	Cyclic AMP	163-167	signal transducer and activator of transcription 3	Mus musculus	40-45
10080923-0	1999	Tyrosine phosphorylation of STAT3 by leptin through leptin receptor in mouse metaphase 2 stage oocyte.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	28-33
10080923-6	1999	Leptin at 15 ng/ml, the concentration observed in follicular fluid, caused tyrosine phosphorylation of STAT3 in mouse M2 stage oocytes.	Tyrosine	75-83	signal transducer and activator of transcription 3	Mus musculus	103-108
10068666-3	1999	Using the full-length cytoplasmic domain and mutants with progressive C-terminal truncations or point mutations, we show that the two membrane-distal tyrosines with the YXXQ motif of LIFR are critical not only for STAT3 activation, but also for growth arrest and differentiation of WEHI-3B D+ cells.	Tyrosine	150-159	signal transducer and activator of transcription 3	Mus musculus	214-219
9510175-4	1998	Activation of Jak kinases by TNF was associated with tyrosine phosphorylation of STAT1, STAT3, STAT5, and STAT6, but not STAT2 or STAT4, showing that TNF acts on a specific subset of these latent cytoplasmic transcription factors in 3T3-L1 adipocytes.	Tyrosine	53-61	signal transducer and activator of transcription 3	Mus musculus	88-93
9500794-5	1998	Using the iNOS inhibitor N6-(iminoethyl)-L-lysine or iNOS knockout mice we found that the activation of the transcriptional factors nuclear factor kappaB and signal transducer and activator of transcription 3 and increases in IL-6 and G-CSF messenger RNA levels in the lungs and livers measured 4 h after resuscitation from hemorrhagic shock were iNOS dependent.	n6-(iminoethyl)-l-lysine	25-49	signal transducer and activator of transcription 3	Mus musculus	158-208
9463379-6	1998	Dimerization of Stat3-GyrB by coumermycin mimicked the effect of IL-10, and expression of DeltaStat3 blocked the anti-proliferative activity of IL-10.	coumermycin	30-41	signal transducer and activator of transcription 3	Mus musculus	16-21
8918689-3	1996	STAT3 is rapidly tyrosine phosphorylated in response to IL-6, ciliary neurotrophic factor, oncostatin M, leukemia inhibitory factor, IL-11, granulocyte colony stimulation factor and epidermal growth factor.	Tyrosine	17-25	signal transducer and activator of transcription 3	Mus musculus	0-5
9566306-5	1998	Here we report that the level of tyrosine-phosphorylated Stat3 decreases rapidly during differentiation induced by treatment of ES1 cells either with retinoic acid (RA) or by withdrawal of LIF.	Tyrosine	33-41	signal transducer and activator of transcription 3	Mus musculus	57-62
9566306-5	1998	Here we report that the level of tyrosine-phosphorylated Stat3 decreases rapidly during differentiation induced by treatment of ES1 cells either with retinoic acid (RA) or by withdrawal of LIF.	Tretinoin	150-163	signal transducer and activator of transcription 3	Mus musculus	57-62
9570135-2	1997	NF-IL6 is phosphorylated and activated by a Ras-dependent MAP kinase cascade, while STAT3/APRF is directly tyrosine-phosphorylated by JAK kinases that associate with the cytoplasmic portion of the receptor, and translocates to the nucleus and activates transcription (JAK-STAT pathway).	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	84-89
9570135-2	1997	NF-IL6 is phosphorylated and activated by a Ras-dependent MAP kinase cascade, while STAT3/APRF is directly tyrosine-phosphorylated by JAK kinases that associate with the cytoplasmic portion of the receptor, and translocates to the nucleus and activates transcription (JAK-STAT pathway).	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	90-94
9570135-3	1997	STAT3 is also tyrosine phosphorylated in response to epidermal growth factor (EGF), granulocyte colony-stimulating factor (G-CSF), leptin and other IL-6-type cytokines including ciliary neurotrophic factor (CNTF), oncostatin M and leukemia inhibitory factor (LIF).	Tyrosine	14-22	signal transducer and activator of transcription 3	Mus musculus	0-5
9548458-3	1997	We report here that both DNA binding activities and tyrosine phosphorylation of STAT3 and STAT5, but not STAT1, are constitutively enhanced in the mouse T cell lymphoma LSTRA, which is a well-characterized cell line that overexpresses Lck protein and exhibits high levels of Lck kinase activity.	Tyrosine	52-60	signal transducer and activator of transcription 3	Mus musculus	80-85
9344858-1	1997	Treatment of cells with PDGF and EGF specifically induces STAT1 and STAT3, which became phosphorylated on tyrosine residues to form homo and heterodimers: in these configurations they translocate into the nucleus where they act as transcription activators.	Tyrosine	106-114	signal transducer and activator of transcription 3	Mus musculus	68-73
9344858-3	1997	Recently it has been shown that v-Src modulates the tyrosine phosphorylation of STAT3 but not of STAT1.	Tyrosine	52-60	signal transducer and activator of transcription 3	Mus musculus	80-85
9344858-5	1997	Both tyrosine phosphorylation and DNA binding activity of STAT1 and STAT3 are up-regulated in c-Src overexpressing cells, while we observe the opposite phenomenon in cells overexpressing the dominant negative Src.	Tyrosine	5-13	signal transducer and activator of transcription 3	Mus musculus	68-73
9169415-3	1997	The carboxyl-terminal region of STAT3, consisting of an acidic domain and containing a serine phosphorylation site, has been proposed to contribute to the induction process.	Serine	87-93	signal transducer and activator of transcription 3	Mus musculus	32-37
9169415-9	1997	Interestingly, whereas receptor-activated STAT3 also enhances stimulation of the haptoglobin promoter by dexamethasone through the glucocorticoid receptor, activated STAT3Delta55C reduces the regulation below the level achieved by the glucocorticoid receptor alone.	Dexamethasone	105-118	signal transducer and activator of transcription 3	Mus musculus	42-47
9122220-3	1997	Expression of this form of gp130 in lymphocytes significantly suppressed interleukin 6-induced tyrosine phosphorylation of endogenous gp130 and a downstream signaling molecule, signal transducer and activator of transcription 3, indicating that this form has a dominant negative function.	Tyrosine	95-103	signal transducer and activator of transcription 3	Mus musculus	177-227
9015216-5	1997	Tyrosine phosphorylation of Stat3 and, to a lesser extent, Stat1 was also detected following G-CSF stimulation.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	28-33
8910398-0	1996	Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain.	Tyrosine	50-58	signal transducer and activator of transcription 3	Mus musculus	0-5
8910398-5	1996	Using a structure-function mutagenesis approach, two tyrosine residues (Tyr427 and Tyr477) in the intracellular domain of the murine IL-10 receptor were found to be redundantly required for receptor function and for activation of Stat3 but not for Stat1 or Stat5.	Tyrosine	53-61	signal transducer and activator of transcription 3	Mus musculus	230-235
8910398-6	1996	Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.	Tyrosine	60-68	signal transducer and activator of transcription 3	Mus musculus	116-121
8910398-6	1996	Twelve amino acid peptides encompassing either of these two tyrosine residues in phosphorylated form coprecipitated Stat3 but not Stat1 and blocked IL-10-induced Stat3 phosphorylation in a cell-free system.	Tyrosine	60-68	signal transducer and activator of transcription 3	Mus musculus	162-167
8910398-8	1996	These data demonstrate that Stat3 but not Stat1 or Stat5 is directly recruited to the ligand-activated IL-10 receptor by binding to specific but redundant receptor intracellular domain sequences containing phosphotyrosine.	Phosphotyrosine	206-221	signal transducer and activator of transcription 3	Mus musculus	28-33
9218758-7	1997	We found that TGF-beta inhibited tyrosine phosphorylation of JAK1, JAK3, STAT3 and STAT5 in Con A blasts from NOD splenocytes and HT-2 cells.	Tyrosine	33-41	signal transducer and activator of transcription 3	Mus musculus	73-78
9002950-2	1997	The signaling pathways responsible for these events are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the signal transducers and activators of transcription (STATs), which are activated by tyrosine phosphorylation.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	191-196
9003804-3	1997	Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3, whereas stimulation of the truncated form of OB-R that is predominantly expressed in dbldb mice failed to do so.	Tyrosine	58-66	signal transducer and activator of transcription 3	Mus musculus	86-91
8683127-6	1996	Similarly, the complex of soluble mIL-11R and IL-11 was capable of mediating an IL-6-type signaling in cells that are naturally deficient in IL-11 response as shown by the activation of STAT1 and STAT3 in mouse embryonal carcinoma cells and human T cells.	mil-11r	34-41	signal transducer and activator of transcription 3	Mus musculus	196-201
8612579-3	1996	Mutational analysis of this region showed that the tyrosine residue with the YXXQ motif was critical not only for Stat3 activation but also for growth arrest and differentiation, accompanied by down-regulation of c-myc and c-myb and immediate early induction of junB and IRF1.	Tyrosine	51-59	signal transducer and activator of transcription 3	Mus musculus	114-119
8657134-5	1996	Treatment of cells with EGF activates Stat1 and Stat3, which become phosphorylated on tyrosine residues to form homo - or heterodimers and translocate into the nucleus, binding to the sis-inducible element (SIE) in the c-fos promoter.	Tyrosine	86-94	signal transducer and activator of transcription 3	Mus musculus	48-53
8657134-8	1996	Here we report that in all v-Src-transformed cell lines examined, Stat3 is constitutively activated to bind to DNA and the phosphorylation of tyrosine on Stat3 is enhanced by the induction of v-Src expression.	Tyrosine	142-150	signal transducer and activator of transcription 3	Mus musculus	154-159
8555464-7	1996	Thrombopoietin also induced tyrosine phosphorylation of Stat3 and Stat5 in FDCP-2 cells genetically engineered to constitutively express human c-Mpl.	Tyrosine	28-36	signal transducer and activator of transcription 3	Mus musculus	56-61
7544789-6	1995	Lastly, we demonstrate that IL-9 induces the tyrosine phosphorylation of Stat3 and in this regard differs from IL-4, which triggers tyrosine phosphorylation of Stat6.	Tyrosine	45-53	signal transducer and activator of transcription 3	Mus musculus	73-78
9095224-2	1996	Within minutes after IL-12 treatment of responsive cells, Stat1, Stat3, and Stat4 are tyrosine phosphorylated.	Tyrosine	86-94	signal transducer and activator of transcription 3	Mus musculus	65-70
8541543-9	1995	Both MGDF and IL-3 induce tyrosine phosphorylation of STAT3 (APRF) and STAT5 (MGF), with MGDF favoring STAT3 while IL-3 predominantly causes STAT5 phosphorylation.	Tyrosine	26-34	signal transducer and activator of transcription 3	Mus musculus	54-59
8541543-9	1995	Both MGDF and IL-3 induce tyrosine phosphorylation of STAT3 (APRF) and STAT5 (MGF), with MGDF favoring STAT3 while IL-3 predominantly causes STAT5 phosphorylation.	Tyrosine	26-34	signal transducer and activator of transcription 3	Mus musculus	61-65
8541543-9	1995	Both MGDF and IL-3 induce tyrosine phosphorylation of STAT3 (APRF) and STAT5 (MGF), with MGDF favoring STAT3 while IL-3 predominantly causes STAT5 phosphorylation.	Tyrosine	26-34	signal transducer and activator of transcription 3	Mus musculus	103-108
7544789-6	1995	Lastly, we demonstrate that IL-9 induces the tyrosine phosphorylation of Stat3 and in this regard differs from IL-4, which triggers tyrosine phosphorylation of Stat6.	Tyrosine	132-140	signal transducer and activator of transcription 3	Mus musculus	73-78
33786638-10	2021	Plasma levels of IL10 were significantly increased by anti-CTLA-4 compared to vehicle but no increase was observed when combining anti-CTLA-4 with GPB730.In conclusion, STAT3 inhibition by GPB730 enhances the antitumoral activity of anti-CTLA-4 and decreases the intratumoral Treg frequency in a prostate cancer mouse model.	treg	276-280	signal transducer and activator of transcription 3	Mus musculus	169-174
7744803-10	1995	Immunoblot analyses confirmed that cytoplasmic STAT3 was heavily phosphorylated on tyrosine in IL-2-stimulated cells, and that phosphorylated STAT3 appeared in the nuclei of these cells.	Tyrosine	83-91	signal transducer and activator of transcription 3	Mus musculus	47-52
8071311-4	1994	We find that Stat3 is tyrosine-phosphorylated and present in mouse liver nuclei following either EGF or lipopolysaccharide administration.	Tyrosine	22-30	signal transducer and activator of transcription 3	Mus musculus	13-18
33822400-3	2021	In this study, we evaluated for the first time a STAT3 inhibitor, Napabucasin, as a therapeutic option for bone metastatic PC.	napabucasin	66-77	signal transducer and activator of transcription 3	Mus musculus	49-54
33822400-7	2021	RESULTS: The small molecule STAT3 inhibitors Stattic and Napabucasin both effectively impaired metastatic potential of PC cells in vitro.	napabucasin	57-68	signal transducer and activator of transcription 3	Mus musculus	28-33
33822771-8	2021	Conversely, the immediate reductions in fasting blood glucose observed with acute amlexanox treatment were mediated by suppression of hepatic glucose production via the activation of STAT3 by adipocyte-secreted IL-6.	amlexanox	82-91	signal transducer and activator of transcription 3	Mus musculus	183-188
33971906-10	2021	RESULTS: Knockdown of the endogenous lncRNA Gm13568 remarkably inhibits the Notch1 expression, astrocytosis, and the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) as well as the production of inflammatory cytokines and chemokines (IL-6, TNF-alpha, IP-10) in IL-9-activated astrocytes, in which Gm13568 associates with the transcriptional co-activators CBP/P300 which are enriched in the promoter of Notch1 genes.	gm13568	44-51	signal transducer and activator of transcription 3	Mus musculus	136-186
33971906-10	2021	RESULTS: Knockdown of the endogenous lncRNA Gm13568 remarkably inhibits the Notch1 expression, astrocytosis, and the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) as well as the production of inflammatory cytokines and chemokines (IL-6, TNF-alpha, IP-10) in IL-9-activated astrocytes, in which Gm13568 associates with the transcriptional co-activators CBP/P300 which are enriched in the promoter of Notch1 genes.	gm13568	44-51	signal transducer and activator of transcription 3	Mus musculus	190-195
33971906-12	2021	CONCLUSIONS: These findings uncover that Gm13568 regulates the production of inflammatory cytokines in active astrocytes and affects the pathogenesis of EAE through the Notch1/STAT3 pathway.	gm13568	41-48	signal transducer and activator of transcription 3	Mus musculus	176-181
33806080-4	2021	In this study, we use synthesized STAT3 decoy oligonucleotides (ODN), which were injected into the tail veins of unilateral ureteral obstruction (UUO) mice, to explore the regulation of autophagy in UUO-induced renal fibrosis.	decoy oligonucleotides	40-62	signal transducer and activator of transcription 3	Mus musculus	34-39
33806080-4	2021	In this study, we use synthesized STAT3 decoy oligonucleotides (ODN), which were injected into the tail veins of unilateral ureteral obstruction (UUO) mice, to explore the regulation of autophagy in UUO-induced renal fibrosis.	odn	64-67	signal transducer and activator of transcription 3	Mus musculus	34-39
33824698-0	2021	Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene.	Raloxifene Hydrochloride	144-154	signal transducer and activator of transcription 3	Mus musculus	124-129
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	signal transducer and activator of transcription 3	Mus musculus	59-109
33824698-6	2021	TAC (four and eight weeks) elevated the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3) and prohibitin2 (PHB2) protein expression.	tac	0-3	signal transducer and activator of transcription 3	Mus musculus	113-118
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	Raloxifene Hydrochloride	44-54	signal transducer and activator of transcription 3	Mus musculus	24-29
33824698-7	2021	Importantly, IL-6/gp130/STAT3 inhibition by raloxifene alleviated TAC-induced myocardial inflammation, cardiac remodeling, and dysfunction.	tac	66-69	signal transducer and activator of transcription 3	Mus musculus	24-29
33824698-10	2021	Conclusion: Inflammation and IL-6/STAT3 signaling were activated in TAC-induced HF in mice, while sustained IL-6 incubation elicited oxidative stress and mitophagy-related protein increase in H9c2 myoblasts, all of which were inhibited by raloxifene.	tac	68-71	signal transducer and activator of transcription 3	Mus musculus	34-39
33803551-7	2021	TauCl also inhibited activation of NFkappaB and STAT3, two key transcription factors mediating proinflammatory signaling.	N-chlorotaurine	0-5	signal transducer and activator of transcription 3	Mus musculus	48-53
33803551-9	2021	Taken together, these results suggest that TauCl exerts the protective effect against colitis through upregulation of Nrf2-dependent cytoprotective gene expression while blocking the proinflammatory signaling mediated by NFkappaB and STAT3.	N-chlorotaurine	43-48	signal transducer and activator of transcription 3	Mus musculus	234-239
33816498-0	2021	Napabucasin Induces Mouse Bone Loss by Impairing Bone Formation via STAT3.	napabucasin	0-11	signal transducer and activator of transcription 3	Mus musculus	68-73
33824326-3	2021	We report that pretreatment of mice with CBLB502 provoked a concomitant activation of NF-kappaB and STAT3 signaling in the liver and reduced hepatic damage in both models.	CBLB502	41-48	signal transducer and activator of transcription 3	Mus musculus	100-105
33824326-8	2021	Taken together, these findings suggest that CBLB502 protects the liver by increasing hepatocyte resistance to acute liver injury through the cooperation of TLR5-NF-kappaB and IL-22-STAT3 signaling pathways.	CBLB502	44-51	signal transducer and activator of transcription 3	Mus musculus	181-186
33816498-1	2021	The novel small molecule Napabucasin (also known as BBI608) was shown to inhibit gene transcription driven by Signal Transducer and Activator of Transcription 3 (STAT3), which is considered a promising anticancer target.	napabucasin	52-58	signal transducer and activator of transcription 3	Mus musculus	110-160
33816498-1	2021	The novel small molecule Napabucasin (also known as BBI608) was shown to inhibit gene transcription driven by Signal Transducer and Activator of Transcription 3 (STAT3), which is considered a promising anticancer target.	napabucasin	52-58	signal transducer and activator of transcription 3	Mus musculus	162-167
33816498-4	2021	In terms of mechanisms, Napabucasin disrupted differentiation of BMSCs by inhibiting the transcription of osteogenic gene osteocalcin (Ocn) through STAT3.	napabucasin	24-35	signal transducer and activator of transcription 3	Mus musculus	148-153
34559878-7	2021	Exposure to pervanadate modulated GGC-induced down-regulation of STAT3 activation and promoted an elevation in the level of PTPepsilon protein.	pervanadate	12-23	signal transducer and activator of transcription 3	Mus musculus	65-70
20102572-8	2010	RESULTS: Feeding mice with ethanol-containing diet for 4 weeks induced greater hepatic injury (elevation of serum ALT) and liver weight in STAT3(E-/-) mice than wild-type control groups.	Ethanol	27-34	signal transducer and activator of transcription 3	Mus musculus	139-144
20102572-9	2010	In addition, ethanol-fed STAT3(E-/-) mice displayed greater hepatic inflammation and substantially elevated serum and hepatic levels of IL-6 and TNF-alpha compared with wild-type mice.	Ethanol	13-20	signal transducer and activator of transcription 3	Mus musculus	25-30
20102572-10	2010	Furthermore, ethanol-fed STAT3(E-/-) mice displayed a greater abundance of apoptotic SECs and higher levels of serum hyaluronic acid than wild-type controls.	Ethanol	13-20	signal transducer and activator of transcription 3	Mus musculus	25-30
20102572-10	2010	Furthermore, ethanol-fed STAT3(E-/-) mice displayed a greater abundance of apoptotic SECs and higher levels of serum hyaluronic acid than wild-type controls.	Hyaluronic Acid	117-132	signal transducer and activator of transcription 3	Mus musculus	25-30
34755577-8	2022	In conclusion, inhibition of miR-17-5p can inhibit myocardial autophagy through targeting STAT3 and then inhibit myocardial remodelling, thereby protecting the myocardium after MI.	mir-17-5p	29-38	signal transducer and activator of transcription 3	Mus musculus	90-95
34270980-8	2022	Notably, FAK knockout increased cellular sensitivity to the Stat3 inhibitor CPA7, while FAK reintroduction restored resistance to this drug.	cpa7	76-80	signal transducer and activator of transcription 3	Mus musculus	60-65
34974400-12	2022	In addition, (R)-BMB decreased the expression of IL-6, IL-17, retinoic acid receptor-related orphan receptor-gamma t (RORt), and phosphorylated STAT3 (p-STAT3) in a dose-dependent manner in the colon tissues.	(r)-bmb	13-20	signal transducer and activator of transcription 3	Mus musculus	144-149
34974400-12	2022	In addition, (R)-BMB decreased the expression of IL-6, IL-17, retinoic acid receptor-related orphan receptor-gamma t (RORt), and phosphorylated STAT3 (p-STAT3) in a dose-dependent manner in the colon tissues.	(r)-bmb	13-20	signal transducer and activator of transcription 3	Mus musculus	153-158
34606948-10	2022	XFBD can reduce bleomycin-induced pulmonary fibrosis by inhibiting IL-6/STAT3 activation and related macrophage infiltration.	Bleomycin	16-25	signal transducer and activator of transcription 3	Mus musculus	72-77
34763177-12	2022	Treatment with leptin peptide resulted in decrease in the intra-testicular leptin levels with increased phosphorylation of Stat3, suggesting improved leptin resistance, which was positively associated with increased germ cell proliferation, elevated testosterone levels, and improved testicular histoarchitecture.	Testosterone	250-262	signal transducer and activator of transcription 3	Mus musculus	123-128
34538671-14	2022	In the xenograft mouse models, DHI dose-dependently suppressed tumor growth and Src and STAT3 phosphorylation.	dehydrosoyasaponin I	31-34	signal transducer and activator of transcription 3	Mus musculus	88-93
34974362-6	2021	The expression of P-IKK protein, PP65 protein and P-STAT3 protein increased in the TCE sensitization positive group, and the downstream inflammatory factors IL-1beta and IL-6 also increased in the TCE sensitization positive group.	Trichloroethylene	83-86	signal transducer and activator of transcription 3	Mus musculus	52-57
34974362-6	2021	The expression of P-IKK protein, PP65 protein and P-STAT3 protein increased in the TCE sensitization positive group, and the downstream inflammatory factors IL-1beta and IL-6 also increased in the TCE sensitization positive group.	Trichloroethylene	197-200	signal transducer and activator of transcription 3	Mus musculus	52-57
34974065-0	2021	A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation.	Methionine	22-32	signal transducer and activator of transcription 3	Mus musculus	16-21
34974065-8	2021	Mechanistically, the alarmin cytokine interleukin (IL)-33 induces a non-canonical STAT3 phosphorylation at serine 727 in ILC2s, leading to translocation of STAT3 into the mitochondria.	Serine	107-113	signal transducer and activator of transcription 3	Mus musculus	82-87
34974065-8	2021	Mechanistically, the alarmin cytokine interleukin (IL)-33 induces a non-canonical STAT3 phosphorylation at serine 727 in ILC2s, leading to translocation of STAT3 into the mitochondria.	Serine	107-113	signal transducer and activator of transcription 3	Mus musculus	156-161
34974065-9	2021	Mitochondrial STAT3 further facilitates adenosine triphosphate synthesis to fuel the methionine cycle and generation of S-adenosylmethionine, which supports the epigenetic reprogramming of type 2 cytokines in ILC2s.	Adenosine	40-49	signal transducer and activator of transcription 3	Mus musculus	14-19
34974065-9	2021	Mitochondrial STAT3 further facilitates adenosine triphosphate synthesis to fuel the methionine cycle and generation of S-adenosylmethionine, which supports the epigenetic reprogramming of type 2 cytokines in ILC2s.	Methionine	85-95	signal transducer and activator of transcription 3	Mus musculus	14-19
34974065-9	2021	Mitochondrial STAT3 further facilitates adenosine triphosphate synthesis to fuel the methionine cycle and generation of S-adenosylmethionine, which supports the epigenetic reprogramming of type 2 cytokines in ILC2s.	S-Adenosylmethionine	120-140	signal transducer and activator of transcription 3	Mus musculus	14-19
34974065-11	2021	CONCLUSION: The mitochondrial STAT3-methionine metabolism pathway is a key regulator that shapes ILC2 effector function through epigenetic regulation, and the related proteins or metabolites represent potential therapeutic targets for allergic lung inflammation.	Methionine	36-46	signal transducer and activator of transcription 3	Mus musculus	30-35
33771600-11	2021	The molecular docking-based interaction studies demonstrated the binding potential of piperine with SMAD1 and STAT3 proteins.	piperine	86-94	signal transducer and activator of transcription 3	Mus musculus	110-115
33232195-7	2021	Besides, miR-30a-5p repressed LPS-elevated phosphorylation levels of the signal transducer and activator of transcription 3 (STAT3) and c-Jun N-terminal kinase (JNK), IkappaBalpha degradation, and NF-kappaB p65 phosphorylation.	-30a-	12-17	signal transducer and activator of transcription 3	Mus musculus	73-123
33232195-7	2021	Besides, miR-30a-5p repressed LPS-elevated phosphorylation levels of the signal transducer and activator of transcription 3 (STAT3) and c-Jun N-terminal kinase (JNK), IkappaBalpha degradation, and NF-kappaB p65 phosphorylation.	-30a-	12-17	signal transducer and activator of transcription 3	Mus musculus	125-130
34954267-0	2022	Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	96-101
34954267-10	2022	It was observed that cucurbitacin B not only inhibited the phosphorylation of JAK2 and STAT3, but also the translocation from the cytosol to the nucleus.	cucurbitacin B	21-35	signal transducer and activator of transcription 3	Mus musculus	87-92
34954267-11	2022	Meanwhile, we observed that cucurbitacin B is bound to STAT3.	cucurbitacin B	28-42	signal transducer and activator of transcription 3	Mus musculus	55-60
34954267-12	2022	Further experimentation demonstrated that cucurbitacin B reduced the polarization of M2 macrophage by down-regulating JAK2/STAT3 signaling pathway.	cucurbitacin B	42-56	signal transducer and activator of transcription 3	Mus musculus	123-128
34954267-14	2022	In vitro study suggested that cucurbitacin inhibited the CRC cells proliferation via JAK2/STAT3 and suppressed the cell migration by suppressing M2-like macrophages polarization.	Cucurbitacins	30-42	signal transducer and activator of transcription 3	Mus musculus	90-95
34582844-15	2022	PKR/STAT3 maybe the potential mechanism, and perioperative varenicline treatment could be an efficient therapeutic strategy for POCD.	Varenicline	59-70	signal transducer and activator of transcription 3	Mus musculus	4-9
34896967-10	2022	Here inhibition mechanism of 6-gingerol is demonstrated on excessive hypertrophy and hyperplasia of adipocytes in white adipose tissue (WAT), which may be related to the regulation of adipocytokines, such as PPARgamma, C/EBPalpha, FABP4 and adiponectin, and the TLR3/IL-6/JAK1/STAT3 axis.	gingerol	29-39	signal transducer and activator of transcription 3	Mus musculus	277-282
34920334-6	2022	Treatment of DAP significantly suppressed the VEGF-A-induced protein expression of VEGF receptor2 (VEGFR2), as well as the activation of downstream signal transducer and activator of transcription 3 (STAT3), AKT, and extracellular signal-regulated kinase (ERK) signaling.	daphnetin	13-16	signal transducer and activator of transcription 3	Mus musculus	148-198
34920334-6	2022	Treatment of DAP significantly suppressed the VEGF-A-induced protein expression of VEGF receptor2 (VEGFR2), as well as the activation of downstream signal transducer and activator of transcription 3 (STAT3), AKT, and extracellular signal-regulated kinase (ERK) signaling.	daphnetin	13-16	signal transducer and activator of transcription 3	Mus musculus	200-205
34920334-8	2022	Alkali burn-induced corneal protein expression of VEGF-A, VEGFR2, phosphorylated (p-)STAT3, p-AKT, and p-ERK in corneal tissue were reduced mainly by DAP.	daphnetin	150-153	signal transducer and activator of transcription 3	Mus musculus	85-90
34894076-9	2022	Short-term vitamin D3, but not long-term pretreatment significantly reduced the phosphorylation of STAT3 and SOCS3, but upregulated the phosphorylation of IkappaBalpha.	Cholecalciferol	11-21	signal transducer and activator of transcription 3	Mus musculus	99-104
34933182-8	2022	Cardiac levels of phosphorylated signal transducer and activator of transcription 3, LCN2, heme oxygenase-1, and NAD (P) H dehydrogenase were markedly greater in DOX-treated WT mice than in DOX-treated LCN2KO mice.	Doxorubicin	162-165	signal transducer and activator of transcription 3	Mus musculus	33-83
34933182-8	2022	Cardiac levels of phosphorylated signal transducer and activator of transcription 3, LCN2, heme oxygenase-1, and NAD (P) H dehydrogenase were markedly greater in DOX-treated WT mice than in DOX-treated LCN2KO mice.	Doxorubicin	190-193	signal transducer and activator of transcription 3	Mus musculus	33-83
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	132-137
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	of medicinal ink	14-30	signal transducer and activator of transcription 3	Mus musculus	132-137
34520830-0	2022	Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulation JAK2/STAT3-mediated iNOS expression.	wemi	32-36	signal transducer and activator of transcription 3	Mus musculus	132-137
34864607-0	2022	Corrigendum to "TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain" (Biochem.	C188-9	16-23	signal transducer and activator of transcription 3	Mus musculus	52-57
34784561-0	2022	MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-kappaB pathway.	mir-1294	0-8	signal transducer and activator of transcription 3	Mus musculus	93-98
34784561-0	2022	MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-kappaB pathway.	ros	20-23	signal transducer and activator of transcription 3	Mus musculus	93-98
34784561-6	2022	A dual-luciferase reporter gene system was used to investigate the relationship between miR-1294 and STAT3.	mir-1294	88-96	signal transducer and activator of transcription 3	Mus musculus	101-106
34784561-10	2022	We also found miR-1294 upregulation inhibited inflammation and epidermal barrier function destruction via targeting STAT3 to suppress NF-kappaB pathway activation in AD.	mir-1294	14-22	signal transducer and activator of transcription 3	Mus musculus	116-121
34624308-8	2022	After intraperitoneal injection of GL, the vasoconstrictive response was significantly reduced compared with that in the mmLDL group, as the Emax was decreased to 97.14 +- 1.20% (P < 0.01); 5-HT1B receptor mRNA and protein expression levels were significantly reduced; STAT3 phosphorylation and p-JAK2 and p-STAT3 protein expression were not significantly changed; and 5-HT1B receptor expression was altered via inhibition of p-STAT3 binding to DNA, which suppressed transcription.	gl	35-37	signal transducer and activator of transcription 3	Mus musculus	269-274
34624308-8	2022	After intraperitoneal injection of GL, the vasoconstrictive response was significantly reduced compared with that in the mmLDL group, as the Emax was decreased to 97.14 +- 1.20% (P < 0.01); 5-HT1B receptor mRNA and protein expression levels were significantly reduced; STAT3 phosphorylation and p-JAK2 and p-STAT3 protein expression were not significantly changed; and 5-HT1B receptor expression was altered via inhibition of p-STAT3 binding to DNA, which suppressed transcription.	gl	35-37	signal transducer and activator of transcription 3	Mus musculus	308-313
34624308-8	2022	After intraperitoneal injection of GL, the vasoconstrictive response was significantly reduced compared with that in the mmLDL group, as the Emax was decreased to 97.14 +- 1.20% (P < 0.01); 5-HT1B receptor mRNA and protein expression levels were significantly reduced; STAT3 phosphorylation and p-JAK2 and p-STAT3 protein expression were not significantly changed; and 5-HT1B receptor expression was altered via inhibition of p-STAT3 binding to DNA, which suppressed transcription.	gl	35-37	signal transducer and activator of transcription 3	Mus musculus	428-433
34861585-10	2022	AL treatment significantly inhibited STAT3 activation in the gastrocnemius (GAS) muscle of cancer cachexia mice.	alantolactone	0-2	signal transducer and activator of transcription 3	Mus musculus	37-42
34861585-11	2022	AL (0.125, 0.25, 0.5 and 1 microM) dose-dependently ameliorated myotube atrophy and STAT3 activation in cultured C2C12 myotubes induced by conditioned medium from C26 tumor cells.	alantolactone	0-2	signal transducer and activator of transcription 3	Mus musculus	84-89
34861585-12	2022	AL also ameliorated C2C12 myotube atrophy induced by IL-6 and inhibited IL-6-mediated STAT3 activation.	alantolactone	0-2	signal transducer and activator of transcription 3	Mus musculus	86-91
34861585-14	2022	Only AL at high doses of more than 5 microM ameliorated lipolysis and STAT3 activation induced in mature 3T3-L1 adipocytes by conditioned medium from C26 tumor cells.	alantolactone	5-7	signal transducer and activator of transcription 3	Mus musculus	70-75
34861585-15	2022	CONCLUSIONS: AL significantly ameliorated muscle atrophy in a cancer cachexia model mainly through the inhibition of the STAT3 pathway.	alantolactone	13-15	signal transducer and activator of transcription 3	Mus musculus	121-126
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	93-98
34931590-7	2022	In addition, curcumin inhibited the expression of Tfh-related transcription factors BCL-6, p-STAT3, Foxp1, Roquin-1, Roquin-2 and SAP, and significantly upregulated the protein levels of Blimp-1 and STAT3 in colon tissue.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	199-204
34911575-5	2021	These mice were treated with STAT3 specific inhibitor, LLL-12 for 2 months followed by neurobehavioral and histopathological assessment.	LLL-12	55-61	signal transducer and activator of transcription 3	Mus musculus	29-34
34911575-7	2021	5XE4 mice treated with the STAT3-specific inhibitor (LLL-12) improved cognitive functions and functional connectivity and augmented cerebral blood flow.	LLL-12	53-59	signal transducer and activator of transcription 3	Mus musculus	27-32
34894199-7	2022	It could upregulate the STAT3/FOXO1/Bcl-6 pathways in the brain and the JNK/FOXO1/Bcl-6 signalling axis in the intestine to regulate glucose metabolite status and ageing in mice.	Glucose	133-140	signal transducer and activator of transcription 3	Mus musculus	24-29
34955850-8	2021	Mechanistically, osteoclastogenesis blockade elicited by NTZ resulted from inhibition of STAT3 phosphorylation, and reduction of the Ca2+ fluorescence intensity and NFATc1 expression.	nitazoxanide	57-60	signal transducer and activator of transcription 3	Mus musculus	89-94
34955850-9	2021	NTZ weakened the binding between STAT3 and the NFATc1 promoter region.	nitazoxanide	0-3	signal transducer and activator of transcription 3	Mus musculus	33-38
34955850-11	2021	In summary, NTZ could inhibit osteoclastogenesis and bone loss through modulation of the receptor activator of NF-kappaB ligand-induced STAT3-NFATc1 signaling pathway, which might be a potential alternative treatment regimen against bone destruction-related diseases including osteoporosis.	nitazoxanide	12-15	signal transducer and activator of transcription 3	Mus musculus	136-141
34699754-0	2021	Berberrubine attenuates potassium oxonate- and hypoxanthine-induced hyperuricemia by regulating urate transporters and JAK2/STAT3 signaling pathway.	berberrubine	0-12	signal transducer and activator of transcription 3	Mus musculus	124-129
34352329-13	2021	Accordingly, the increased phosphorylation of Src downstream components (JNK, ERK, P38 and STAT3) induced by LPS was remarkably diminished by QHZG, suggesting the involvement of Src/MAPK/STAT3 pathway in the inhibitory effects of QHZG on spleen injury in mice.	qhzg	142-146	signal transducer and activator of transcription 3	Mus musculus	91-96
34352329-13	2021	Accordingly, the increased phosphorylation of Src downstream components (JNK, ERK, P38 and STAT3) induced by LPS was remarkably diminished by QHZG, suggesting the involvement of Src/MAPK/STAT3 pathway in the inhibitory effects of QHZG on spleen injury in mice.	qhzg	142-146	signal transducer and activator of transcription 3	Mus musculus	187-192
34352329-13	2021	Accordingly, the increased phosphorylation of Src downstream components (JNK, ERK, P38 and STAT3) induced by LPS was remarkably diminished by QHZG, suggesting the involvement of Src/MAPK/STAT3 pathway in the inhibitory effects of QHZG on spleen injury in mice.	qhzg	230-234	signal transducer and activator of transcription 3	Mus musculus	91-96
34352329-13	2021	Accordingly, the increased phosphorylation of Src downstream components (JNK, ERK, P38 and STAT3) induced by LPS was remarkably diminished by QHZG, suggesting the involvement of Src/MAPK/STAT3 pathway in the inhibitory effects of QHZG on spleen injury in mice.	qhzg	230-234	signal transducer and activator of transcription 3	Mus musculus	187-192
34352329-14	2021	CONCLUSION: Our study demonstrated that QHZG protected mice from LPS-induced acute spleen injury via inhibition of Src/MAPK/Stat3 signal pathway.	qhzg	40-44	signal transducer and activator of transcription 3	Mus musculus	124-129
34747340-0	2021	MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-kappaB pathway.	mir-125-	0-8	signal transducer and activator of transcription 3	Mus musculus	141-146
34224294-9	2021	In conclusion, LINC00511 promotes the GC cell proliferation and migration via targeting the miR-625-5p/STAT3 axis, implying that LINC00511 can function as a target for GC therapy.	linc00511	15-24	signal transducer and activator of transcription 3	Mus musculus	103-108
34224294-9	2021	In conclusion, LINC00511 promotes the GC cell proliferation and migration via targeting the miR-625-5p/STAT3 axis, implying that LINC00511 can function as a target for GC therapy.	linc00511	129-138	signal transducer and activator of transcription 3	Mus musculus	103-108
34363611-10	2021	CONCLUSION AND IMPLICATIONS: These results amount to the first preclinical evidence that PZQ may effectively treat psoriasis, and suggest that PZQ alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.	Praziquantel	89-92	signal transducer and activator of transcription 3	Mus musculus	189-194
34363611-10	2021	CONCLUSION AND IMPLICATIONS: These results amount to the first preclinical evidence that PZQ may effectively treat psoriasis, and suggest that PZQ alleviates symptoms in mice by inhibiting STAT3 phosphorylation, thereby suppressing Th17 immune responses.	Praziquantel	143-146	signal transducer and activator of transcription 3	Mus musculus	189-194
34747340-12	2021	In addition, miR-125-5p up-regulation significantly reduced the expression of IL-6 R in the UC mice, and reduced the expression levels of JAK1, STAT3 and p65 phosphorylation.	mir-125-5p	13-23	signal transducer and activator of transcription 3	Mus musculus	144-149
34747340-13	2021	MiR-125-5p targeting IL-6 R regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-kappaB pathway.	mir-125-5p	0-10	signal transducer and activator of transcription 3	Mus musculus	147-152
34785732-7	2021	MARCH3 deficiency enhances dextran sulfate sodium (DSS)-induced STAT3 activation, increases the expression of inflammatory cytokines, and exacerbates colitis, as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice.	Dextran Sulfate	27-49	signal transducer and activator of transcription 3	Mus musculus	64-69
34785732-7	2021	MARCH3 deficiency enhances dextran sulfate sodium (DSS)-induced STAT3 activation, increases the expression of inflammatory cytokines, and exacerbates colitis, as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice.	Dextran Sulfate	51-54	signal transducer and activator of transcription 3	Mus musculus	64-69
34423886-0	2021	Limonin ameliorates acute pancreatitis by suppressing JAK2/STAT3 signaling pathway.	limonin	0-7	signal transducer and activator of transcription 3	Mus musculus	59-64
34423886-9	2021	Thus, our results demonstrate that limonin can ameliorate AP in two mice models via suppressing JAK2/STAT3 signaling pathway.	limonin	35-42	signal transducer and activator of transcription 3	Mus musculus	101-106
34605108-2	2021	Thymoquinone (TQ) exerts its anti-neoplastic effect through diverse mechanisms, including STAT3 inhibition.	thymoquinone	0-12	signal transducer and activator of transcription 3	Mus musculus	90-95
34600949-7	2021	The results demonstrated that following DOX or DA administration, STAT1/phosphorylated (p)-STAT1 decreased, whereas STAT3/p-STAT3, STAT5/p-STAT5 and STAT6/p-STAT6 increased, which was accompanied by a decrease in the MDSC proportion in each experimental group.	Doxorubicin	40-43	signal transducer and activator of transcription 3	Mus musculus	116-121
34600949-7	2021	The results demonstrated that following DOX or DA administration, STAT1/phosphorylated (p)-STAT1 decreased, whereas STAT3/p-STAT3, STAT5/p-STAT5 and STAT6/p-STAT6 increased, which was accompanied by a decrease in the MDSC proportion in each experimental group.	Doxorubicin	40-43	signal transducer and activator of transcription 3	Mus musculus	124-129
34600949-7	2021	The results demonstrated that following DOX or DA administration, STAT1/phosphorylated (p)-STAT1 decreased, whereas STAT3/p-STAT3, STAT5/p-STAT5 and STAT6/p-STAT6 increased, which was accompanied by a decrease in the MDSC proportion in each experimental group.	Dopamine	47-49	signal transducer and activator of transcription 3	Mus musculus	116-121
34600949-7	2021	The results demonstrated that following DOX or DA administration, STAT1/phosphorylated (p)-STAT1 decreased, whereas STAT3/p-STAT3, STAT5/p-STAT5 and STAT6/p-STAT6 increased, which was accompanied by a decrease in the MDSC proportion in each experimental group.	Dopamine	47-49	signal transducer and activator of transcription 3	Mus musculus	124-129
34605108-0	2021	Thymoquinone upregulates miR-125a-5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma.	thymoquinone	0-12	signal transducer and activator of transcription 3	Mus musculus	49-54
34921636-4	2021	TM4SF5-transgenic and diethylnitrosamine (DEN)-induced liver cancer mouse models exhibited fibrotic and cancerous livers, respectively, with enhanced TM4SF5, pY705STAT3, collagen I, and laminin gamma2 levels.	Diethylnitrosamine	22-40	signal transducer and activator of transcription 3	Mus musculus	163-168
34921636-4	2021	TM4SF5-transgenic and diethylnitrosamine (DEN)-induced liver cancer mouse models exhibited fibrotic and cancerous livers, respectively, with enhanced TM4SF5, pY705STAT3, collagen I, and laminin gamma2 levels.	Diethylnitrosamine	42-45	signal transducer and activator of transcription 3	Mus musculus	163-168
34887262-12	2021	SN-38 suppressed the levels of c-Myc and STAT3 proteins, which controlled PD-L1 expression.	Irinotecan	0-5	signal transducer and activator of transcription 3	Mus musculus	41-46
34547509-7	2021	ERK and JAK-STAT signaling were blocked using the inhibitors U0126 and Tofacitinib, respectively.	U 0126	61-66	signal transducer and activator of transcription 3	Mus musculus	12-16
34547509-7	2021	ERK and JAK-STAT signaling were blocked using the inhibitors U0126 and Tofacitinib, respectively.	tofacitinib	71-82	signal transducer and activator of transcription 3	Mus musculus	12-16
34853306-6	2021	Remarkably, prednisone induces a shutdown of bypass RTK signaling and inhibits key resistance signals such as STAT3, YAP and TNF-NF-kappaB.	Prednisone	12-22	signal transducer and activator of transcription 3	Mus musculus	110-115
33556301-0	2021	Alantolactone alleviates collagen-induced arthritis and inhibits Th17 cell differentiation through modulation of STAT3 signalling.	alantolactone	0-13	signal transducer and activator of transcription 3	Mus musculus	113-118
33556301-8	2021	Alantolactone also reduced the number of splenic Th17 cells and the capability of naive CD4+ T cells to differentiate into the Th17 subset by downregulating STAT3/RORgammat signalling by as early as 24 h of treatment.	alantolactone	0-13	signal transducer and activator of transcription 3	Mus musculus	157-162
34634743-14	2021	CONCLUSION: GSS protects against cerebral I/RI through the expression of alpha7nAChR and inhibition of the JAK2/STAT3 pathway.	gss	12-15	signal transducer and activator of transcription 3	Mus musculus	112-117
34634743-16	2021	The downstream signals of GSS, alpha7nAChR- JAK2/STAT3 could also be potential targets for the treatment of I/RI.	gss	26-29	signal transducer and activator of transcription 3	Mus musculus	49-54
34605108-2	2021	Thymoquinone (TQ) exerts its anti-neoplastic effect through diverse mechanisms, including STAT3 inhibition.	thymoquinone	14-16	signal transducer and activator of transcription 3	Mus musculus	90-95
34943841-8	2021	We found that oncostatin induced strong Osmr and p-STAT3 expression in these cells which is associated with reduction of proliferation and promotion of astrocytic versus oligodendrocytic differentiation.	oncostatin	14-24	signal transducer and activator of transcription 3	Mus musculus	51-56
34839589-12	2022	Mice with STZ-induced diabetes showed elevated expressions of circZNF532, STAT3, but decreased level of miR-20b-5p compared with the controls.	Streptozocin	10-13	signal transducer and activator of transcription 3	Mus musculus	74-79
34900688-7	2021	In conclusion, our results demonstrated that combination of AF and ICG-001 suppressed the proliferation and metastasis of colon cancer by inhibiting STAT3 phosphorylation.	ICG 001	67-74	signal transducer and activator of transcription 3	Mus musculus	149-154
34789834-0	2021	S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling.	s-1-propenylcysteine	0-20	signal transducer and activator of transcription 3	Mus musculus	111-116
34821076-8	2022	Mice lacking Il6st, encoding gp130, in myocytes (cKO) and WT controls, as well as mice treated with the JAK2 inhibitor AG490 or vehicle were exposed to CLP or sham surgery for 24 or 96 h. RESULTS: Analyses of differentially expressed genes in RNAseq (>=2-log2-fold change, P < 0.01) revealed an activation of IL-6-signalling and JAK/STAT-signalling pathways in muscle of septic mice, which occurred after 24 h and lasted at least for 96 h during sepsis.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	119-124	signal transducer and activator of transcription 3	Mus musculus	333-337
34821076-17	2022	AG490 treatment reduced STAT3 phosphorylation (-22.2%, P < 0.05) and attenuated TA muscle atrophy in septic mice (29.6% relative reduction of muscle weight loss, P < 0.05).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	24-29
34858728-10	2021	Further study revealed that the expressions of IL-6 and JAK/STAT3 signaling pathways were upregulated by chronic stress in mice, and this upregulation could be inhibited by propranolol.	Propranolol	173-184	signal transducer and activator of transcription 3	Mus musculus	60-65
34787735-0	2022	Isoorientin suppresses sepsis-induced acute lung injury in mice by activating an EPCR-dependent JAK2/STAT3 pathway.	homoorientin	0-11	signal transducer and activator of transcription 3	Mus musculus	101-106
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	17-20	signal transducer and activator of transcription 3	Mus musculus	117-122
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	17-20	signal transducer and activator of transcription 3	Mus musculus	167-172
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	84-87	signal transducer and activator of transcription 3	Mus musculus	117-122
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	84-87	signal transducer and activator of transcription 3	Mus musculus	167-172
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	251-254	signal transducer and activator of transcription 3	Mus musculus	117-122
34787735-8	2022	Mechanistically, ISO reduced the shedding of EPCR in the endothelial cell membrane; ISO treatment activated the JAK2/STAT3 signaling pathway through EPCR and the JAK2/STAT3 pathway inhibitors repressed the anti-inflammatory and antioxidant effects of ISO.	homoorientin	251-254	signal transducer and activator of transcription 3	Mus musculus	167-172
34787735-9	2022	In general, ISO suppressed sepsis-induced ALI in mice by activating an EPCR-dependent JAK2/STAT3 pathway.	homoorientin	12-15	signal transducer and activator of transcription 3	Mus musculus	91-96
34808617-0	2021	Homoharringtonine inhibits Alzheimer"s disease progression by reducing neuroinflammation via STAT3 signaling in APP/PS1 mice.	Homoharringtonine	0-17	signal transducer and activator of transcription 3	Mus musculus	93-98
34833950-0	2021	Nifuroxazide Mitigates Angiogenesis in Ehlrich"s Solid Carcinoma: Molecular Docking, Bioinformatic and Experimental Studies on Inhibition of Il-6/Jak2/Stat3 Signaling.	nifuroxazide	0-12	signal transducer and activator of transcription 3	Mus musculus	151-156
34793974-6	2022	Knockdown of STAT3 in Tregs overcomes this resistance and results in Treg reprogramming and recruitment and activation of antigen presenting cells.	tregs	22-27	signal transducer and activator of transcription 3	Mus musculus	13-18
34793974-6	2022	Knockdown of STAT3 in Tregs overcomes this resistance and results in Treg reprogramming and recruitment and activation of antigen presenting cells.	treg	69-73	signal transducer and activator of transcription 3	Mus musculus	13-18
34516993-4	2021	MAIN METHODS: In the study, we used the mixture of adenine and potassium oxonate to perform kidney injury and fibrosis in hyperuricemic mice, accompanied by STAT3 activation in tubular and interstitial cells.	Adenine	51-58	signal transducer and activator of transcription 3	Mus musculus	157-162
34516993-4	2021	MAIN METHODS: In the study, we used the mixture of adenine and potassium oxonate to perform kidney injury and fibrosis in hyperuricemic mice, accompanied by STAT3 activation in tubular and interstitial cells.	potassium oxonate	63-80	signal transducer and activator of transcription 3	Mus musculus	157-162
34516993-5	2021	KEY FINDINGS: Treatment with STAT3 inhibitor S3I-201 improved renal dysfunction, reduced serum uric acid level, and delayed the progression of kidney fibrosis.	Uric Acid	95-104	signal transducer and activator of transcription 3	Mus musculus	29-34
34833950-9	2021	Furthermore, nifuroxazide dose-dependently downregulated STAT3 phosphorylation (60% and 30% reductions, respectively).	nifuroxazide	13-25	signal transducer and activator of transcription 3	Mus musculus	57-62
34758338-5	2021	The STAT3-RGS4 pathway was also activated in neonatal brains during poly(I:C)-induced maternal immune activation, which mimics viral infection during pregnancy.	Poly I-C	68-77	signal transducer and activator of transcription 3	Mus musculus	4-9
34901113-6	2021	Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs.	Glucosamine	13-17	signal transducer and activator of transcription 3	Mus musculus	171-176
34901113-6	2021	Furthermore, GlcN increased the expression of arginase 1 and inducible nitric oxide synthase to produce high levels of reactive oxygen species, which was regulated by the STAT3 and ERK1/2 pathways, to increase the immunosuppressive ability of MDSCs.	Reactive Oxygen Species	119-142	signal transducer and activator of transcription 3	Mus musculus	171-176
34858422-7	2021	Mechanistic study revealed that miR-21 down-regulates IL-10 expression through direct targeting of IL-10, and suppresses reprogramming of Tregs into IL-17-secreting cells through down-regulating Stat3 activity.	tregs	138-143	signal transducer and activator of transcription 3	Mus musculus	195-200
34727296-8	2021	Early but not the late intrathecal injection of C-176 attenuated SNI-induced pain hypersensitivity, microglia activation, proinflammatory factors, and phosphorylated JAK2/STAT3 in the spinal cord dorsal horn, and the analgesic effect of C-176 was greatly abolished by recombinant IL-6 following SNI.	C-176	48-53	signal transducer and activator of transcription 3	Mus musculus	171-176
34737419-0	2021	L-Cysteine attenuates osteopontin-mediated neuroinflammation following hypoxia-ischemia insult in neonatal mice by inducing S-sulfhydration of Stat3.	Cysteine	0-10	signal transducer and activator of transcription 3	Mus musculus	143-148
34737419-11	2021	Our data demonstrate that L-Cysteine administration effectively attenuates the OPN-mediated neuroinflammation by inducing S-sulfhydration of Stat3, which contributes to its anti-inflammatory effect following HI insult in neonatal mice.	Cysteine	26-36	signal transducer and activator of transcription 3	Mus musculus	141-146
34732697-10	2021	Here, the use of carbon ion beams (5 GyE) for melanoma-bearing mice was found to reduce the population of MDSC in the bone marrow, peripheral blood, and spleen of the animals via a JAK2/STAT3-dependent mechanism.	Carbon	17-23	signal transducer and activator of transcription 3	Mus musculus	186-191
34537180-10	2021	In conclusion, these findings demonstrated that LXA4 alleviated allergic airway inflammation and remodeling in asthmatic mice, which may be related to the inhibition of STAT3 pathway.	lipoxin A4	48-52	signal transducer and activator of transcription 3	Mus musculus	169-174
34771643-9	2021	Overall, Tris DBA functions as a good inhibitor of STAT3 signaling in preclinical HCC and MM models.	Tromethamine	9-13	signal transducer and activator of transcription 3	Mus musculus	51-56
34594406-14	2021	Furthermore, the ratios of p-JAK2/JAK2 and p-STAT3/STAT3 were decreased following treatment with Se or MEG3 silencing.	Selenium	97-99	signal transducer and activator of transcription 3	Mus musculus	45-50
34594406-14	2021	Furthermore, the ratios of p-JAK2/JAK2 and p-STAT3/STAT3 were decreased following treatment with Se or MEG3 silencing.	Selenium	97-99	signal transducer and activator of transcription 3	Mus musculus	51-56
34365219-0	2021	Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM.	bazedoxifene	0-12	signal transducer and activator of transcription 3	Mus musculus	32-37
34365219-4	2021	Previously, we identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including IL6, in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activationTo target prolonged STAT3 activation, we used the small molecule inhibitor bazedoxifene (BZA), which blocks formation of the IL6 receptor-gp130 complex.	bazedoxifene	332-344	signal transducer and activator of transcription 3	Mus musculus	70-75
34365219-4	2021	Previously, we identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including IL6, in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activationTo target prolonged STAT3 activation, we used the small molecule inhibitor bazedoxifene (BZA), which blocks formation of the IL6 receptor-gp130 complex.	bazedoxifene	332-344	signal transducer and activator of transcription 3	Mus musculus	153-158
34365219-4	2021	Previously, we identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including IL6, in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activationTo target prolonged STAT3 activation, we used the small molecule inhibitor bazedoxifene (BZA), which blocks formation of the IL6 receptor-gp130 complex.	bazedoxifene	346-349	signal transducer and activator of transcription 3	Mus musculus	70-75
34365219-4	2021	Previously, we identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including IL6, in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activationTo target prolonged STAT3 activation, we used the small molecule inhibitor bazedoxifene (BZA), which blocks formation of the IL6 receptor-gp130 complex.	bazedoxifene	346-349	signal transducer and activator of transcription 3	Mus musculus	153-158
34365219-4	2021	Previously, we identified a novel mechanism of biphasic activation of STAT3 in response to gp130-linked cytokines, including IL6, in which activation of STAT3 is prolonged by circumventing the negative regulatory mechanisms induced by its initial activationTo target prolonged STAT3 activation, we used the small molecule inhibitor bazedoxifene (BZA), which blocks formation of the IL6 receptor-gp130 complex.	bazedoxifene	346-349	signal transducer and activator of transcription 3	Mus musculus	277-282
34365219-10	2021	Our findings reveal a mechanism of sustained STAT3 signaling in GBM and reveal its role in GSC maintenance, and we identify BZA as a novel candidate for treating GBM.	bazedoxifene	124-127	signal transducer and activator of transcription 3	Mus musculus	45-50
34776934-6	2021	An investigation of the molecular mechanism of the effects of gliquidone on LPS-stimulated proinflammatory responses showed that in BV2 microglial cells, gliquidone significantly decreased LPS-induced proinflammatory cytokine levels and inhibited ERK/STAT3/NF-kappaB phosphorylation by altering NLRP3 inflammasome activation.	gliquidone	62-72	signal transducer and activator of transcription 3	Mus musculus	251-256
34951180-2	2021	The present study investigated the anti-rheumatoid arthritis effect of oxymatrine(OMT), the active component of Sophorae Flavescentis Radix by observing its effect on the function of B lymphocytes in collagen-induced arthritis(CIA) mice through the Toll-like receptor 9(TLR9)/myeloid differentiation factor 88(MyD88)/signal transducer and activator of transcription 3(STAT3) pathway.	oxymatrine	71-81	signal transducer and activator of transcription 3	Mus musculus	317-367
34951180-2	2021	The present study investigated the anti-rheumatoid arthritis effect of oxymatrine(OMT), the active component of Sophorae Flavescentis Radix by observing its effect on the function of B lymphocytes in collagen-induced arthritis(CIA) mice through the Toll-like receptor 9(TLR9)/myeloid differentiation factor 88(MyD88)/signal transducer and activator of transcription 3(STAT3) pathway.	oxymatrine	71-81	signal transducer and activator of transcription 3	Mus musculus	368-373
34951180-2	2021	The present study investigated the anti-rheumatoid arthritis effect of oxymatrine(OMT), the active component of Sophorae Flavescentis Radix by observing its effect on the function of B lymphocytes in collagen-induced arthritis(CIA) mice through the Toll-like receptor 9(TLR9)/myeloid differentiation factor 88(MyD88)/signal transducer and activator of transcription 3(STAT3) pathway.	omt	82-85	signal transducer and activator of transcription 3	Mus musculus	317-367
34951180-2	2021	The present study investigated the anti-rheumatoid arthritis effect of oxymatrine(OMT), the active component of Sophorae Flavescentis Radix by observing its effect on the function of B lymphocytes in collagen-induced arthritis(CIA) mice through the Toll-like receptor 9(TLR9)/myeloid differentiation factor 88(MyD88)/signal transducer and activator of transcription 3(STAT3) pathway.	omt	82-85	signal transducer and activator of transcription 3	Mus musculus	368-373
34951180-12	2021	Therefore, OMT may alleviate rheumatoid arthritis by regulating TLR9/MyD88/STAT3 pathway in B lymphocytes, providing a valuable reference for the application of OMT in the clinical treatment of rheumatoid arthritis.	omt	11-14	signal transducer and activator of transcription 3	Mus musculus	75-80
34951180-12	2021	Therefore, OMT may alleviate rheumatoid arthritis by regulating TLR9/MyD88/STAT3 pathway in B lymphocytes, providing a valuable reference for the application of OMT in the clinical treatment of rheumatoid arthritis.	omt	161-164	signal transducer and activator of transcription 3	Mus musculus	75-80
34777338-7	2021	This study investigated the immunotherapeutic ability of a porphyrin based small molecule inhibitor of IL-10/STAT3 axis, 5, 15-diphenyl porphyrin (DPP), in improving anti-TB immunity offered by second generation recombinant BCG30 (rBCG30-ARMF-II ) vaccine in mice.	Porphyrins	59-68	signal transducer and activator of transcription 3	Mus musculus	109-114
34777338-7	2021	This study investigated the immunotherapeutic ability of a porphyrin based small molecule inhibitor of IL-10/STAT3 axis, 5, 15-diphenyl porphyrin (DPP), in improving anti-TB immunity offered by second generation recombinant BCG30 (rBCG30-ARMF-II ) vaccine in mice.	5,15-diphenylporphyrin	121-145	signal transducer and activator of transcription 3	Mus musculus	109-114
34777338-7	2021	This study investigated the immunotherapeutic ability of a porphyrin based small molecule inhibitor of IL-10/STAT3 axis, 5, 15-diphenyl porphyrin (DPP), in improving anti-TB immunity offered by second generation recombinant BCG30 (rBCG30-ARMF-II ) vaccine in mice.	dpp	147-150	signal transducer and activator of transcription 3	Mus musculus	109-114
34688828-0	2022	MicroRNA-29b ameliorates hepatic inflammation via suppression of STAT3 in alcohol-associated liver disease.	Alcohols	74-81	signal transducer and activator of transcription 3	Mus musculus	65-70
34688828-11	2022	miR-29b plays a hepatoprotective role in alcohol induced inflammation and liver injury by targeting STAT3.	mir-29b	0-7	signal transducer and activator of transcription 3	Mus musculus	100-105
34688828-11	2022	miR-29b plays a hepatoprotective role in alcohol induced inflammation and liver injury by targeting STAT3.	Alcohols	41-48	signal transducer and activator of transcription 3	Mus musculus	100-105
34686650-8	2021	High-dose/short-term treatment with diethylnitrosamine (DEN) increased the ALT level, proinflammatory gene expression levels, and STAT3 and NF-kappaB activation in CPAP Tg mice; low-dose/long-term DEN treatment induced more severe liver tumor formation in CPAP Tg mice than in WT mice.	Diethylnitrosamine	36-54	signal transducer and activator of transcription 3	Mus musculus	130-135
34686650-8	2021	High-dose/short-term treatment with diethylnitrosamine (DEN) increased the ALT level, proinflammatory gene expression levels, and STAT3 and NF-kappaB activation in CPAP Tg mice; low-dose/long-term DEN treatment induced more severe liver tumor formation in CPAP Tg mice than in WT mice.	Diethylnitrosamine	56-59	signal transducer and activator of transcription 3	Mus musculus	130-135
34744770-6	2021	We determined the signal transducer and activator of transcription 3 (STAT3) phosphorylation at tyrosine (Tyr)705 by western blot and the expression of ATF6, 78-kDa glucose-regulated protein (GRP78), and C/-EBP homologous protein (CHOP) related to ER stress by immunofluorescence (IF), western blot, and qRT-PCR; they were then verified on the cell model.	Tyrosine	96-104	signal transducer and activator of transcription 3	Mus musculus	70-75
34744770-6	2021	We determined the signal transducer and activator of transcription 3 (STAT3) phosphorylation at tyrosine (Tyr)705 by western blot and the expression of ATF6, 78-kDa glucose-regulated protein (GRP78), and C/-EBP homologous protein (CHOP) related to ER stress by immunofluorescence (IF), western blot, and qRT-PCR; they were then verified on the cell model.	Tyrosine	106-109	signal transducer and activator of transcription 3	Mus musculus	70-75
34715887-11	2021	Moreover, the protein levels of p-Stat3, p-Plk1 and p-Cdk1 were suppressed by TC-S 7010.	Aurora A Inhibitor I	78-87	signal transducer and activator of transcription 3	Mus musculus	34-39
34706270-0	2022	Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	18-23
34706270-4	2022	In this study, we use a chemical proteomics strategy that has identified STAT3, a transcription factor considered to be undruggable, as a direct functional protein target of rapamycin.	Sirolimus	174-183	signal transducer and activator of transcription 3	Mus musculus	73-78
34706270-6	2022	Furthermore, we show that rapamycin suppresses tumor growth along with a decreased expression of STAT3 and c-Myc in an in vivo xenograft mouse model for hepatocellular carcinoma.	Sirolimus	26-35	signal transducer and activator of transcription 3	Mus musculus	97-102
34706270-7	2022	Our data suggest that rapamycin acts directly on STAT3 to decrease its transcription activity, providing important information for the pharmacological and pharmaceutical development of STAT3 inhibitors for cancer therapy.	Sirolimus	22-31	signal transducer and activator of transcription 3	Mus musculus	49-54
34706270-7	2022	Our data suggest that rapamycin acts directly on STAT3 to decrease its transcription activity, providing important information for the pharmacological and pharmaceutical development of STAT3 inhibitors for cancer therapy.	Sirolimus	22-31	signal transducer and activator of transcription 3	Mus musculus	185-190
34776934-6	2021	An investigation of the molecular mechanism of the effects of gliquidone on LPS-stimulated proinflammatory responses showed that in BV2 microglial cells, gliquidone significantly decreased LPS-induced proinflammatory cytokine levels and inhibited ERK/STAT3/NF-kappaB phosphorylation by altering NLRP3 inflammasome activation.	gliquidone	154-164	signal transducer and activator of transcription 3	Mus musculus	251-256
34776934-7	2021	In primary astrocytes, gliquidone selectively affected LPS-mediated proinflammatory cytokine expression and decreased STAT3/NF-kappaB signaling in an NLRP3-independent manner.	gliquidone	23-33	signal transducer and activator of transcription 3	Mus musculus	118-123
34609854-5	2021	In neonatal murine cardiac fibroblasts, norepinephrine increased reactive oxygen species (ROS), accumulation of catechol-modified protein adducts, expression and secretion of collagens I/III, and other markers of profibrotic activation including STAT3 phosphorylation.	Norepinephrine	40-54	signal transducer and activator of transcription 3	Mus musculus	246-251
34707773-8	2021	The results show that bavachin induces ferroptosis via the STAT3/P53/SLC7A11 axis in OS cells.	bavachin	22-30	signal transducer and activator of transcription 3	Mus musculus	59-64
34671017-4	2021	We find that bilobalide inhibits Abeta-induced and STAT3-dependent expression of TNF-alpha, IL-1beta, and IL-6 in primary astrocyte culture.	bilobalide	13-23	signal transducer and activator of transcription 3	Mus musculus	51-56
34645472-11	2021	NF-kappaB inhibition and STAT3 activation caused by a decrease in ROS levels were responsible for glycogen mobilization-induced A1-like and A2-like astrocyte transformation after I/R.	Reactive Oxygen Species	66-69	signal transducer and activator of transcription 3	Mus musculus	25-30
34174222-0	2021	Inhibitory activity of acteoside in melanoma via regulation of the ERbeta-Ras/Raf1-STAT3 pathway.	acteoside	23-32	signal transducer and activator of transcription 3	Mus musculus	83-88
34174222-9	2021	RESULTS: The results showed that acteoside inhibited melanoma growth, alleviated inflammation levels in mice, attenuated ROS and apoptosis levels in the spleen, downregulated the levels of CD31, survivin, Ras, Raf1, p-STAT3, and Bcl-2, and upregulated the levels of ERbeta, Bax, cleaved caspase-3, and cleaved caspase-9.	acteoside	33-42	signal transducer and activator of transcription 3	Mus musculus	218-223
34174222-11	2021	CONCLUSION: Acteoside may promote the apoptosis of tumor cells by regulating the ERbeta-Ras/Raf1-STAT3 signaling axis, thus inhibiting the occurrence and development of melanoma.	acteoside	12-21	signal transducer and activator of transcription 3	Mus musculus	97-102
34091208-2	2021	Herein, to inhibit COX-2 and block STAT3 signaling, we disclosed 27 N-anthraniloyl tryptamine compounds based on the combination of melatonin derivatives and N-substituted anthranilic acid derivatives.	n-anthraniloyl tryptamine	68-93	signal transducer and activator of transcription 3	Mus musculus	35-40
34091208-2	2021	Herein, to inhibit COX-2 and block STAT3 signaling, we disclosed 27 N-anthraniloyl tryptamine compounds based on the combination of melatonin derivatives and N-substituted anthranilic acid derivatives.	Melatonin	132-141	signal transducer and activator of transcription 3	Mus musculus	35-40
34645472-11	2021	NF-kappaB inhibition and STAT3 activation caused by a decrease in ROS levels were responsible for glycogen mobilization-induced A1-like and A2-like astrocyte transformation after I/R.	Glycogen	98-106	signal transducer and activator of transcription 3	Mus musculus	25-30
34645472-13	2021	CONCLUSIONS: Our data suggest that ROS-mediated NF-kappaB inhibition and STAT3 activation are the key pathways for glycogen mobilization-induced neuroprotection and provide a promising metabolic target for brain reperfusion injury in ischemic stroke.	Glycogen	115-123	signal transducer and activator of transcription 3	Mus musculus	73-78
34274354-0	2021	TTI-101: A competitive inhibitor of STAT3 that spares oxidative phosphorylation and reverses mechanical allodynia in mouse models of neuropathic pain.	C188-9	0-7	signal transducer and activator of transcription 3	Mus musculus	36-41
34622462-0	2022	Troxerutin regulates HIF-1alpha by activating JAK2/STAT3 signaling to inhibit oxidative stress, inflammation, and apoptosis of cardiomyocytes induced by H2 O2.	Hydrogen Peroxide	153-158	signal transducer and activator of transcription 3	Mus musculus	51-56
34622462-13	2022	To sum up, troxerutin could regulate HIF-1alpha by activating JAK2/STAT3 signaling to inhibit oxidative stress, inflammation, and apoptosis of cardiomyocytes induced by H2 O2 .	Hydrogen Peroxide	169-174	signal transducer and activator of transcription 3	Mus musculus	67-72
34569224-8	2021	The activity of PGP-I was further identified to be highly related to the phosphorylation of STAT3, which could be impeded by the natural product parthenolide.	parthenolide	145-157	signal transducer and activator of transcription 3	Mus musculus	92-97
34698771-8	2021	E-LPs promoted the phosphorylation of STAT3, whereas Stattic, an inhibitor of STAT3, restored the expression of alpha2-macroglobulin decreased by E-LPs.	e-lps	0-5	signal transducer and activator of transcription 3	Mus musculus	38-43
34698771-8	2021	E-LPs promoted the phosphorylation of STAT3, whereas Stattic, an inhibitor of STAT3, restored the expression of alpha2-macroglobulin decreased by E-LPs.	e-lps	146-151	signal transducer and activator of transcription 3	Mus musculus	38-43
34698771-8	2021	E-LPs promoted the phosphorylation of STAT3, whereas Stattic, an inhibitor of STAT3, restored the expression of alpha2-macroglobulin decreased by E-LPs.	e-lps	146-151	signal transducer and activator of transcription 3	Mus musculus	78-83
34601984-9	2022	pPeOp exhibited promising anticancer effect in the xenograft nude mice model, established by STAT3 knock down gastric cancer cells.Thus, JAK/STAT3 inhibition partially contributed to the anticancer effect of pPeOp, which may serve as a novel strategy for gastric cancer.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1960385.	ppeop	0-5	signal transducer and activator of transcription 3	Mus musculus	93-98
34601984-9	2022	pPeOp exhibited promising anticancer effect in the xenograft nude mice model, established by STAT3 knock down gastric cancer cells.Thus, JAK/STAT3 inhibition partially contributed to the anticancer effect of pPeOp, which may serve as a novel strategy for gastric cancer.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1960385.	ppeop	208-213	signal transducer and activator of transcription 3	Mus musculus	93-98
34601984-9	2022	pPeOp exhibited promising anticancer effect in the xenograft nude mice model, established by STAT3 knock down gastric cancer cells.Thus, JAK/STAT3 inhibition partially contributed to the anticancer effect of pPeOp, which may serve as a novel strategy for gastric cancer.Supplemental data for this article is available online at https://doi.org/10.1080/01635581.2021.1960385.	ppeop	208-213	signal transducer and activator of transcription 3	Mus musculus	141-146
34790781-10	2021	(III) Transcriptome sequencing showed that differentially expressed genes in the combination group compared with the venetoclax monotherapy group were mainly enriched in the PI3K-AKT pathway and JAK2/STAT3 pathway.	venetoclax	117-127	signal transducer and activator of transcription 3	Mus musculus	200-205
34790781-13	2021	Conclusions: Chidamide combined with venetoclax synergistically promoted apoptosis in AML cell lines and primary cells by inhibiting activation of the PI3K/AKT pathway and JAK2/STAT3 pathway.	N-(2-amino-5-fluorobenzyl)-4-(N-(pyridine-3-acrylyl)aminomethyl)benzamide	13-22	signal transducer and activator of transcription 3	Mus musculus	177-182
34707773-0	2021	Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells.	bavachin	0-8	signal transducer and activator of transcription 3	Mus musculus	41-46
34688463-7	2021	In addition, the effect of PB on BACE1 expression and Abeta secretion was reversed by treatment with FoxO1 siRNA and STAT3 antagonist S3I-201.	physalin B	27-29	signal transducer and activator of transcription 3	Mus musculus	117-122
34688463-8	2021	In conclusion, these data demonstrated that PB can effectively down-regulate the expression of BACE1 to reduce Abetasecretion by activating the expression of FoxO1 and inhibiting the phosphorylation of STAT3.	physalin B	44-46	signal transducer and activator of transcription 3	Mus musculus	202-207
34117816-13	2021	In addition, western blot also showed that naringenin inhibited JAK2/STAT3 signaling by suppressing SHP-1 expression in vascular endothelial cells of mice.	naringenin	43-53	signal transducer and activator of transcription 3	Mus musculus	69-74
34156153-14	2021	Furthermore, treatment with the p-STAT3 inhibitor AG490 mitigated the effect of AIM2 on BBB breakdown.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	50-55	signal transducer and activator of transcription 3	Mus musculus	34-39
34117816-14	2021	CONCLUSION: Naringenin suppressed the activation of JAK2/STAT3 signaling pathway and promoted SHP-1 expression, leading to ameliorated hypertension in pregnancy.	naringenin	12-22	signal transducer and activator of transcription 3	Mus musculus	57-62
34358862-11	2021	Moreover, the mRNA level of IL-6, IL-1beta and IL-33 and the phosphorylation of JAK2 and STAT3 were also up-regulated in the hepatocyte treated with high concentration of glucose.	Glucose	171-178	signal transducer and activator of transcription 3	Mus musculus	89-94
34464722-9	2021	Blockade of JAK2 or STAT3 phosphorylation significantly reduced the ability of DPN to down-regulate P2X7R expression and the ability of ERB-041 and DPN to inhibit IL-1beta release from RAW264.7 cells.	NAD	79-82	signal transducer and activator of transcription 3	Mus musculus	20-25
34414450-0	2021	Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity.	Fatty Acids, Omega-3	0-35	signal transducer and activator of transcription 3	Mus musculus	50-55
34414450-9	2021	The results revealed that both endogenous and exogenous n-3 PUFAs significantly aggravated APAP-induced liver damage via the downregulation of STAT3 signaling.	Fatty Acids, Omega-3	56-65	signal transducer and activator of transcription 3	Mus musculus	143-148
34414450-9	2021	The results revealed that both endogenous and exogenous n-3 PUFAs significantly aggravated APAP-induced liver damage via the downregulation of STAT3 signaling.	Acetaminophen	91-95	signal transducer and activator of transcription 3	Mus musculus	143-148
34414450-12	2021	It was concluded that n-3 PUFAs inhibit IL-11 production and further STAT3 activation in hepatocytes during APAP-induced liver injury.	Fatty Acids, Omega-3	22-31	signal transducer and activator of transcription 3	Mus musculus	69-74
34414450-12	2021	It was concluded that n-3 PUFAs inhibit IL-11 production and further STAT3 activation in hepatocytes during APAP-induced liver injury.	Acetaminophen	108-112	signal transducer and activator of transcription 3	Mus musculus	69-74
34558146-0	2021	Lycorine inhibits cell proliferation and induced oxidative stress-mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT-3 cells.	lycorine	0-8	signal transducer and activator of transcription 3	Mus musculus	111-116
34558146-7	2021	Furthermore, we analyzed that the molecular mechanical action of lycorine considerably repressed JAK1/STAT3 transactional activation and decrease its downstream molecules Bcl-2, and enhances the expressional activity of Bax, cytochrome c, caspase 3 and 9 in HT-3 cells.	lycorine	65-73	signal transducer and activator of transcription 3	Mus musculus	102-107
34186047-0	2021	The HSP90 inhibitor, XL888, enhanced cell apoptosis via downregulating STAT3 after insufficient radiofrequency ablation in hepatocellular carcinoma.	XL 888	21-26	signal transducer and activator of transcription 3	Mus musculus	71-76
34186047-9	2021	XL888 attenuated the complex formation of HSP90 and STAT3, leading to decreased expression levels of STAT3 and p-STAT3.	XL 888	0-5	signal transducer and activator of transcription 3	Mus musculus	52-57
34186047-9	2021	XL888 attenuated the complex formation of HSP90 and STAT3, leading to decreased expression levels of STAT3 and p-STAT3.	XL 888	0-5	signal transducer and activator of transcription 3	Mus musculus	101-106
34186047-9	2021	XL888 attenuated the complex formation of HSP90 and STAT3, leading to decreased expression levels of STAT3 and p-STAT3.	XL 888	0-5	signal transducer and activator of transcription 3	Mus musculus	113-118
34176097-0	2021	MiR-135-5p Alleviates Bone Cancer Pain by Regulating Astrocyte-Mediated Neuroinflammation in Spinal Cord through JAK2/STAT3 Signaling Pathway.	mir-135-5p	0-10	signal transducer and activator of transcription 3	Mus musculus	118-123
34176097-7	2021	By conducting in vitro experiments, it was shown that the miR-135-5P mimics lowered the level of JAK2/STAT3 proteins and inflammatory factors in astrocytes.	mir-135-5p	58-68	signal transducer and activator of transcription 3	Mus musculus	102-107
34176097-9	2021	Meanwhile, reduced activation of astrocytes in the spinal cord, as well as decreased expression of JAK2/STAT3 and inflammatory mediators, were found after miR-135-5p agonist treatment.	mir-135-5p	155-165	signal transducer and activator of transcription 3	Mus musculus	104-109
34176097-10	2021	Collectively, the results showed that miR-135-5p could potentially reduce BCP in mice through inhibiting astrocyte-mediated neuroinflammation and blocking of the JAK2/STAT3 signaling pathway, indicating that the upregulation of miR-135-5P could be a therapeutic focus in BCP treatment.	mir-135-5p	38-48	signal transducer and activator of transcription 3	Mus musculus	167-172
34250656-0	2021	Parthenolide, bioactive compound of Chrysanthemum parthenium L., ameliorates fibrogenesis and inflammation in hepatic fibrosis via regulating the crosstalk of TLR4 and STAT3 signaling pathway.	parthenolide	0-12	signal transducer and activator of transcription 3	Mus musculus	168-173
34250656-1	2021	The current study focused on the regulatory effects of parthenolide (PNL), a bioactive component derived from Chrysanthemum parthenium L., against hepatic fibrosis via regulating the crosstalk of toll-like receptor 4 (TLR4) and signal transducer and activator of transcription 3 (STAT3) in activated hepatic stellate cells (HSCs).	parthenolide	55-67	signal transducer and activator of transcription 3	Mus musculus	280-285
34638977-0	2021	Donepezil Regulates LPS and Abeta-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling.	Donepezil	0-9	signal transducer and activator of transcription 3	Mus musculus	95-100
34117816-0	2021	Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signaling pathway in mice.	naringenin	0-10	signal transducer and activator of transcription 3	Mus musculus	74-79
34233590-6	2021	In vivo studies have shown that curcumin significantly reduces the mortality of mice and control the occurrence and size of liver tumors by inhibiting the IL-6/STAT3 signaling pathway.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	160-165
34638977-5	2021	Importantly, we found that donepezil suppressed LPS-induced AKT/MAPK signaling, the NLRP3 inflammasome, and transcription factor NF-kB/STAT3 phosphorylation to reduce neuroinflammatory responses.	Donepezil	27-36	signal transducer and activator of transcription 3	Mus musculus	135-140
34588425-0	2021	The JAK2 inhibitor TG101209 exhibits anti-tumor and chemotherapeutic sensitizing effects on Burkitt lymphoma cells by inhibiting the JAK2/STAT3/c-MYB signaling axis.	TG101209	19-27	signal transducer and activator of transcription 3	Mus musculus	138-143
34588425-6	2021	The mechanistic study indicated that TG101209, by suppressing the JAK2/STAT3/c-MYB signaling axis and crosstalk between the downstream signaling pathways, plays an antilymphoma role.	TG101209	37-45	signal transducer and activator of transcription 3	Mus musculus	71-76
34650433-0	2021	Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.	alantolactone	26-39	signal transducer and activator of transcription 3	Mus musculus	10-15
34621323-14	2021	Further investigation revealed that the activities of STAT3, AKT, and ERK were augmented in diabetic hearts but decreased in FTZ-treated cardiac tissues.	CHEMBL1354522	125-128	signal transducer and activator of transcription 3	Mus musculus	54-59
34621323-15	2021	Conclusion: Our results suggest that FTZ exhibits therapeutic properties against DCM by ameliorating hyperglycemia-induced inflammation and fibrosis via at least partial inhibition of AKT, ERK, and STAT3 signaling pathways.	CHEMBL1354522	37-40	signal transducer and activator of transcription 3	Mus musculus	198-203
34569365-5	2021	The effects of Aq, EA and Q3ME were assessed on B16F10 cells by determining the proliferation, viability, apoptosis induction and the expression and phosphorylation of STAT3.	quercetin 3-O-methyl ether	26-30	signal transducer and activator of transcription 3	Mus musculus	168-173
34569365-7	2021	Aq, EA and Q3ME presented antiproliferative activity on B6F10 cells through p-STAT3 inhibition and early and late apoptosis induction (EC50 EA= <=0.1 microg/ml; Aq= 316 +- 30 microg/ml; Q3ME= <0.1 microg/ml).	quercetin 3-O-methyl ether	11-15	signal transducer and activator of transcription 3	Mus musculus	78-83
34544479-11	2021	Propranolol pretreatment significantly enhanced the p-STAT3 (2.9-fold, P < 0.05) and suppressed p-PKR (65.94% +- 10.11%, P < 0.05) compared with T1012G only group.	Propranolol	0-11	signal transducer and activator of transcription 3	Mus musculus	54-59
34650433-4	2021	Alantolactone (ALT), a sesquiterpene lactone compound, can selectively suppress the phosphorylation of STAT3.	alantolactone	0-13	signal transducer and activator of transcription 3	Mus musculus	103-108
34650433-4	2021	Alantolactone (ALT), a sesquiterpene lactone compound, can selectively suppress the phosphorylation of STAT3.	alantolactone	15-18	signal transducer and activator of transcription 3	Mus musculus	103-108
34650433-4	2021	Alantolactone (ALT), a sesquiterpene lactone compound, can selectively suppress the phosphorylation of STAT3.	sesquiterpene lactone	23-44	signal transducer and activator of transcription 3	Mus musculus	103-108
34659904-9	2021	In addition, the anti-cancer effects of HedC were observed in in vivo xenograft mice model, and HedC treatment induced the decreased PCNA and p-STAT3 as well as the increased p53 and cleaved caspase-3.	Pulsatilla saponin A	40-44	signal transducer and activator of transcription 3	Mus musculus	144-149
34659904-9	2021	In addition, the anti-cancer effects of HedC were observed in in vivo xenograft mice model, and HedC treatment induced the decreased PCNA and p-STAT3 as well as the increased p53 and cleaved caspase-3.	Pulsatilla saponin A	96-100	signal transducer and activator of transcription 3	Mus musculus	144-149
34576143-0	2021	Nitro-Oleic Acid Inhibits Stemness Maintenance and Enhances Neural Differentiation of Mouse Embryonic Stem Cells via STAT3 Signaling.	nitro-oleic acid	0-16	signal transducer and activator of transcription 3	Mus musculus	117-122
34576143-1	2021	Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity.	nitro-oleic acid	0-16	signal transducer and activator of transcription 3	Mus musculus	109-159
34576143-1	2021	Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity.	nitro-oleic acid	0-16	signal transducer and activator of transcription 3	Mus musculus	161-166
34576143-1	2021	Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity.	no2-oa	18-24	signal transducer and activator of transcription 3	Mus musculus	109-159
34576143-1	2021	Nitro-oleic acid (NO2-OA), pluripotent cell-signaling mediator, was recently described as a modulator of the signal transducer and activator of transcription 3 (STAT3) activity.	no2-oa	18-24	signal transducer and activator of transcription 3	Mus musculus	161-166
34576143-5	2021	The effects of NO2-OA on mESC correlated with reduced phosphorylation of STAT3.	Nitrogen Dioxide	15-18	signal transducer and activator of transcription 3	Mus musculus	73-78
34358632-0	2021	STAT3 activation in hippocampal neural stem cells and cognitive deficits in mice following short-term cuprizone exposure.	Cuprizone	102-111	signal transducer and activator of transcription 3	Mus musculus	0-5
34358632-6	2021	We then examined whether short-term CPZ exposure might induce activation of signal transducer and activator of transcription 3 (STAT3), which plays a major role in cytokine receptor signaling.	Cuprizone	36-39	signal transducer and activator of transcription 3	Mus musculus	76-126
34358632-6	2021	We then examined whether short-term CPZ exposure might induce activation of signal transducer and activator of transcription 3 (STAT3), which plays a major role in cytokine receptor signaling.	Cuprizone	36-39	signal transducer and activator of transcription 3	Mus musculus	128-133
34358632-7	2021	The densities of phosphorylated STAT3-positive (pSTAT3+) NSCs were higher in CPZ-fed mice than in normal-fed mice, while those of pSTAT3+ NPCs/NGCs were very low in both groups.	Cuprizone	77-80	signal transducer and activator of transcription 3	Mus musculus	32-37
34358632-9	2021	These findings suggest that short-term CPZ exposure inhibits differentiation of NSCs into NPCs via activation of STAT3, which may in part underlie cognitive deficits.	Cuprizone	39-42	signal transducer and activator of transcription 3	Mus musculus	113-118
34518585-9	2021	Moreover, leptin-induced p-JAK2 and p-STAT3 signaling in the hypothalamus of Stz + TUDCA mice was improved, accompanied by reduced acute food intake after leptin stimulation.	Streptozocin	77-80	signal transducer and activator of transcription 3	Mus musculus	38-43
34496957-12	2021	After osteogenic induction for 14d, the significantly diminished calcium deposits were found in Stat3 CKO BMSCs.	Calcium	65-72	signal transducer and activator of transcription 3	Mus musculus	96-101
34146587-0	2021	Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-kappaB/STAT3 signaling cascades.	Diosgenin	0-9	signal transducer and activator of transcription 3	Mus musculus	131-136
34110044-0	2021	Astrocyte-selective STAT3 knockdown rescues methamphetamine withdrawal-disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1.	Methamphetamine	44-59	signal transducer and activator of transcription 3	Mus musculus	20-25
34110044-0	2021	Astrocyte-selective STAT3 knockdown rescues methamphetamine withdrawal-disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1.	Glutamic Acid	145-154	signal transducer and activator of transcription 3	Mus musculus	20-25
34110044-6	2021	Most importantly, selective knockdown of astrocytic STAT3 in vivo in dCA1 restored the astrocytic capacity of Glu clearance, normalized Glu levels at dCA1 synapses, and finally rescued METH withdrawal-disrupted spatial memory in mice.	Glutamic Acid	110-113	signal transducer and activator of transcription 3	Mus musculus	52-57
34110044-6	2021	Most importantly, selective knockdown of astrocytic STAT3 in vivo in dCA1 restored the astrocytic capacity of Glu clearance, normalized Glu levels at dCA1 synapses, and finally rescued METH withdrawal-disrupted spatial memory in mice.	Glutamic Acid	136-139	signal transducer and activator of transcription 3	Mus musculus	52-57
34110044-6	2021	Most importantly, selective knockdown of astrocytic STAT3 in vivo in dCA1 restored the astrocytic capacity of Glu clearance, normalized Glu levels at dCA1 synapses, and finally rescued METH withdrawal-disrupted spatial memory in mice.	Methamphetamine	185-189	signal transducer and activator of transcription 3	Mus musculus	52-57
34110044-7	2021	Thus, astrocytic Glu clearance system, especially STAT3, serves as a novel target for future therapies against METH neurotoxicity.	Glutamic Acid	17-20	signal transducer and activator of transcription 3	Mus musculus	50-55
34110044-7	2021	Thus, astrocytic Glu clearance system, especially STAT3, serves as a novel target for future therapies against METH neurotoxicity.	Methamphetamine	111-115	signal transducer and activator of transcription 3	Mus musculus	50-55
34146587-3	2021	The consequence of diosgenin treatment on NF-kappaB/STAT3 activation in PCa cells as well as transgenic mouse model was determined.	Diosgenin	19-28	signal transducer and activator of transcription 3	Mus musculus	52-57
34146587-5	2021	Diosgenin abrogated NF-kappaB/STAT3 activation and this action was caused as a result of suppression of protein kinases and reporter gene activity that led to a substantial reduction in the expression of various tumorigenic gene products.	Diosgenin	0-9	signal transducer and activator of transcription 3	Mus musculus	30-35
34183374-6	2021	To address the functional role of STAT3 in adult beta-cells, we generated mice with tamoxifen-inducible partial or full deletion of STAT3 in beta-cells and fed them a high-fat diet before analysis.	Tamoxifen	84-93	signal transducer and activator of transcription 3	Mus musculus	132-137
34540843-8	2021	IL-12Rbeta1 and tyrosine kinase 2 gene (Tyk2) silencing experiments and phosphotyrosine of signal transducer and activator of transcription 3 (p-STAT3) suppression experiments indicated the IL-12Rbeta1/TYK2/STAT3 signaling was essential in IL-12-induced osteogenic differentiation enhancement of BM-MSCs.	Phosphotyrosine	72-87	signal transducer and activator of transcription 3	Mus musculus	91-141
34540843-8	2021	IL-12Rbeta1 and tyrosine kinase 2 gene (Tyk2) silencing experiments and phosphotyrosine of signal transducer and activator of transcription 3 (p-STAT3) suppression experiments indicated the IL-12Rbeta1/TYK2/STAT3 signaling was essential in IL-12-induced osteogenic differentiation enhancement of BM-MSCs.	Phosphotyrosine	72-87	signal transducer and activator of transcription 3	Mus musculus	207-212
34539408-12	2021	Moreover, DHA impacts STAT3-induced EMT and MMPS in tumor tissue.	artenimol	10-13	signal transducer and activator of transcription 3	Mus musculus	22-27
34335912-12	2021	Signaling studies demonstrated that hispidin markedly suppresses LPS-induced mitogen activated protein kinases and JAK1/STAT3 activation, although not the NF-kappaB signaling pathway.	hispidin	36-44	signal transducer and activator of transcription 3	Mus musculus	120-125
34342041-0	2021	The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment in P. gingivalis LPS-induced periodontitis mice.	treg	22-26	signal transducer and activator of transcription 3	Mus musculus	31-36
34342041-9	2021	These effects were reversed by C188-9, a STAT3 inhibitor.	C188-9	31-37	signal transducer and activator of transcription 3	Mus musculus	41-46
34320467-0	2021	The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.	gemcitabine	66-77	signal transducer and activator of transcription 3	Mus musculus	139-144
34265077-0	2021	Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways.	zeaxanthin dipalmitate	18-40	signal transducer and activator of transcription 3	Mus musculus	129-134
34564613-0	2021	Effect of (-)-Epigallocatechin Gallate on Activation of JAK/STAT Signaling Pathway by Staphylococcal Enterotoxin A. Staphylococcal enterotoxin A (SEA), which is a superantigen toxin protein, binds to cytokine receptor gp130.	epigallocatechin gallate	10-38	signal transducer and activator of transcription 3	Mus musculus	60-64
34564613-6	2021	Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3.	(-)-3""-me-egcg	9-24	signal transducer and activator of transcription 3	Mus musculus	151-156
34564613-6	2021	Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3.	epigallocatechin gallate	75-79	signal transducer and activator of transcription 3	Mus musculus	151-156
34564613-6	2021	Although (-)-3""-Me-EGCG did not inhibit SEA-induced phosphorylated STAT3, EGCG and (-)-4""-Me-EGCG significantly inhibited SEA-induced phosphorylated STAT3.	(-)-4""-me-egcg	84-99	signal transducer and activator of transcription 3	Mus musculus	151-156
34564613-7	2021	It was thought that the hydroxyl group at position 3 of the galloyl group in the EGCG was responsible for binding to SEA and suppressing SEA-induced phosphorylation of STAT3.	epigallocatechin gallate	81-85	signal transducer and activator of transcription 3	Mus musculus	168-173
34564613-8	2021	Through protein thermal shift assay in vitro, the binding of the gp130 receptor to SEA and the phosphorylation of STAT3 were inhibited by the interaction between EGCG and SEA.	epigallocatechin gallate	162-166	signal transducer and activator of transcription 3	Mus musculus	114-119
34564613-9	2021	As far as we know, this is the first report to document that EGCG inhibits the binding of the gp130 receptor to SEA and the associated phosphorylation of STAT3.	epigallocatechin gallate	61-65	signal transducer and activator of transcription 3	Mus musculus	154-159
34465981-0	2021	Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-kappaB P65/STAT3 and TGFbeta1/Smads Signaling Pathways.	puerarin	0-8	signal transducer and activator of transcription 3	Mus musculus	90-95
34504808-6	2021	Mice were infected with T. cruzi and then treated daily from 70 to 91 days post infection (DPI) with TTI-101, a small molecule inhibitor of STAT3; benznidazole; a combination of benznidazole and TTI-101; or vehicle alone.	C188-9	101-108	signal transducer and activator of transcription 3	Mus musculus	140-145
34504808-8	2021	By the end of treatment, STAT3 inhibition with TTI-101 eliminated cardiac fibrosis and fibrosis biomarkers but increased cardiac inflammation; serum levels of interleukin-6 (IL-6), and IFN-gamma; cardiac gene expression of STAT1 and nuclear factor-kappaB (NF-kappaB); and upregulation of IL-6 and Type I and Type II IFN responses.	C188-9	47-54	signal transducer and activator of transcription 3	Mus musculus	25-30
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	184-188	signal transducer and activator of transcription 3	Mus musculus	261-266
34399682-11	2021	Furthermore, the expression of Smad4 was decreased and was inversely correlated with miR-3074-5p expression, and overexpression of Smad4 partially reversed the viability inhibition of iron-overloaded MC3T3-E1 cells by relieving the suppression of ERK, AKT, and Stat3 phosphorylation, suggesting its regulatory role in the viability inhibition of iron-overloaded MC3T3-E1 cells.	Iron	346-350	signal transducer and activator of transcription 3	Mus musculus	261-266
34483908-12	2021	In addition, phosphorylation of signal transducer and activator of transcription-3 (STAT3) was significantly reduced in DHA treatment mice, suggesting that the IL-23/Th17 axis plays a pivotal role.	artenimol	120-123	signal transducer and activator of transcription 3	Mus musculus	32-82
34483908-12	2021	In addition, phosphorylation of signal transducer and activator of transcription-3 (STAT3) was significantly reduced in DHA treatment mice, suggesting that the IL-23/Th17 axis plays a pivotal role.	artenimol	120-123	signal transducer and activator of transcription 3	Mus musculus	84-89
34440829-4	2021	Furthermore, WD feeding also upregulated inflammation, hyperplasia, and tumorigenicity levels through the activation of STAT3 and NF-kappaB signaling in an AOM/DSS-induced mouse model.	Dextran Sulfate	160-163	signal transducer and activator of transcription 3	Mus musculus	120-125
34440829-6	2021	Additionally, orlistat inhibited the extent of inflammation, hyperplasia, and tumor progression via the inhibition of STAT3 and NF-kappaB activation.	Orlistat	14-22	signal transducer and activator of transcription 3	Mus musculus	118-123
34440829-8	2021	The results of this study indicate that orlistat alleviates colon cancer promotion in WD-driven CAC mice by suppressing inflammation, especially by inhibiting STAT3 and NF-kappaB activation.	Orlistat	40-48	signal transducer and activator of transcription 3	Mus musculus	159-164
34422067-11	2021	Moreover, docetaxel injection increased levels of TNF-alpha and IL-6 in plasma and expressions of phospho-NF-kappaB and phospho-STAT3 in both of lumbar spinal cord and sciatic nerves, while SH003 treatment inhibited those changes.	Docetaxel	10-19	signal transducer and activator of transcription 3	Mus musculus	128-133
34422067-12	2021	Taken together, it is worth noting that TNF-alpha and IL-6 in plasma and phospho-NF-kappaB and phospho-STAT3 in spinal cord and sciatic nerves are putative biomarkers of docetaxel-induced peripheral neuropathy (DIPN) in mouse models.	Docetaxel	170-179	signal transducer and activator of transcription 3	Mus musculus	103-108
34439133-8	2021	Upregulation of signal transducer and activator of transcription 3 (STAT3) and proviral insertion in murine-1 (PIM-1) were associated with combined apalutamide/GSK690693.	apalutamide	148-159	signal transducer and activator of transcription 3	Mus musculus	16-66
34439133-8	2021	Upregulation of signal transducer and activator of transcription 3 (STAT3) and proviral insertion in murine-1 (PIM-1) were associated with combined apalutamide/GSK690693.	apalutamide	148-159	signal transducer and activator of transcription 3	Mus musculus	68-73
34439133-8	2021	Upregulation of signal transducer and activator of transcription 3 (STAT3) and proviral insertion in murine-1 (PIM-1) were associated with combined apalutamide/GSK690693.	GSK690693	160-169	signal transducer and activator of transcription 3	Mus musculus	16-66
34439133-8	2021	Upregulation of signal transducer and activator of transcription 3 (STAT3) and proviral insertion in murine-1 (PIM-1) were associated with combined apalutamide/GSK690693.	GSK690693	160-169	signal transducer and activator of transcription 3	Mus musculus	68-73
34362948-0	2021	Mechanism of TCONS_00147848 regulating apoptosis of nasal mucosa cells and alleviating allergic rhinitis through FOSL2-mediated JAK/STAT3 signaling pathway.	tcons_00147848	13-27	signal transducer and activator of transcription 3	Mus musculus	132-137
34362948-11	2021	In nasal mucosa cells of mice, TCONS_00147848 can target FOSL2, interacting with STAT3.	tcons_00147848	31-45	signal transducer and activator of transcription 3	Mus musculus	81-86
34348786-0	2021	Modaline sulfate promotes Oct4 expression and maintains self-renewal and pluripotency of stem cells through JAK/STAT3 and Wnt signaling pathways.	MODALINE SULFATE	0-16	signal transducer and activator of transcription 3	Mus musculus	112-117
34314061-8	2021	VGLL4 knockdown attenuated CNH-induced PH and pulmonary artery remodeling by blunting signal transducer and activator of transcription 3 (STAT3) signaling; conversely, VGLL4 overexpression exacerbated the development of PH.	1-hydroxy-11-norcadinan-5-en-4-one	27-30	signal transducer and activator of transcription 3	Mus musculus	86-136
34314061-8	2021	VGLL4 knockdown attenuated CNH-induced PH and pulmonary artery remodeling by blunting signal transducer and activator of transcription 3 (STAT3) signaling; conversely, VGLL4 overexpression exacerbated the development of PH.	1-hydroxy-11-norcadinan-5-en-4-one	27-30	signal transducer and activator of transcription 3	Mus musculus	138-143
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	97-102
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	149-154
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	155-160
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	97-102
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	149-154
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	155-160
34314061-10	2021	Notably, abrogation of VGLL4 acetylation reversed CNH-induced PH and pulmonary artery remodeling and suppressed STAT3 signaling.	1-hydroxy-11-norcadinan-5-en-4-one	50-53	signal transducer and activator of transcription 3	Mus musculus	112-117
34314061-11	2021	Finally, STAT3 knockdown alleviated CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	36-39	signal transducer and activator of transcription 3	Mus musculus	9-14
34314061-12	2021	In conclusion, VGLL4 acetylation upregulation could contribute to CNH-induced PH and pulmonary artery remodeling via STAT3 signaling, and abrogation of VGLL4 acetylation reversed CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	66-69	signal transducer and activator of transcription 3	Mus musculus	117-122
34413167-0	2021	Cystathionine beta-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis.	tregs	78-83	signal transducer and activator of transcription 3	Mus musculus	48-53
34413167-11	2021	Mechanistically, CBS facilitated the expression cleaved Caspase-3 in tumor cells, and on the other hand, suppressed Foxp3 expression in Tregs via inactivating IL-6/STAT3 pathway.	tregs	136-141	signal transducer and activator of transcription 3	Mus musculus	164-169
34322848-9	2021	Mmu-miR-338-3p exerted profound inhibition effects on GBM cell growth in vitro or in vivo through targeting Prex2, leading to attenuation of (Protein kinase B) AKT/Signal transducer and activator of transcription 3 (STAT3) signaling activation.	mmu-mir-338-3p	0-14	signal transducer and activator of transcription 3	Mus musculus	164-214
34322848-9	2021	Mmu-miR-338-3p exerted profound inhibition effects on GBM cell growth in vitro or in vivo through targeting Prex2, leading to attenuation of (Protein kinase B) AKT/Signal transducer and activator of transcription 3 (STAT3) signaling activation.	mmu-mir-338-3p	0-14	signal transducer and activator of transcription 3	Mus musculus	216-221
34217710-13	2021	Unlike ATO 40 mg/kg, the expression levels of ERK, AKT, NF-kB, Rho, STAT3, Ets-1, HIF-1alpha, and VEGF proteins and genes were significantly increased in ATO 2 mg/kg compared to the control.	Atorvastatin	7-10	signal transducer and activator of transcription 3	Mus musculus	68-73
34217710-13	2021	Unlike ATO 40 mg/kg, the expression levels of ERK, AKT, NF-kB, Rho, STAT3, Ets-1, HIF-1alpha, and VEGF proteins and genes were significantly increased in ATO 2 mg/kg compared to the control.	Atorvastatin	154-157	signal transducer and activator of transcription 3	Mus musculus	68-73
34363008-8	2022	(R)-TML104 treatment markedly induced the SIRT1-signal transducer and activator of transcription 3 (STAT3) interaction and reduced acetylation of STAT3, thus inhibiting the inflammatory response mediated by the interleukin 6-STAT3 pathway.	(r)-tml104	0-10	signal transducer and activator of transcription 3	Mus musculus	42-98
34363008-8	2022	(R)-TML104 treatment markedly induced the SIRT1-signal transducer and activator of transcription 3 (STAT3) interaction and reduced acetylation of STAT3, thus inhibiting the inflammatory response mediated by the interleukin 6-STAT3 pathway.	(r)-tml104	0-10	signal transducer and activator of transcription 3	Mus musculus	100-105
34363008-8	2022	(R)-TML104 treatment markedly induced the SIRT1-signal transducer and activator of transcription 3 (STAT3) interaction and reduced acetylation of STAT3, thus inhibiting the inflammatory response mediated by the interleukin 6-STAT3 pathway.	(r)-tml104	0-10	signal transducer and activator of transcription 3	Mus musculus	146-151
34363008-8	2022	(R)-TML104 treatment markedly induced the SIRT1-signal transducer and activator of transcription 3 (STAT3) interaction and reduced acetylation of STAT3, thus inhibiting the inflammatory response mediated by the interleukin 6-STAT3 pathway.	(r)-tml104	0-10	signal transducer and activator of transcription 3	Mus musculus	225-230
34363008-9	2022	The effect of (R)-TML104 on SIRT1-STAT3 interaction was reversed by treatment with a SIRT1 inhibitor selisistat (EX527).	(r)-tml104	14-24	signal transducer and activator of transcription 3	Mus musculus	34-39
34363008-9	2022	The effect of (R)-TML104 on SIRT1-STAT3 interaction was reversed by treatment with a SIRT1 inhibitor selisistat (EX527).	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	101-111	signal transducer and activator of transcription 3	Mus musculus	34-39
34341336-0	2021	Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.	polyarginine	0-15	signal transducer and activator of transcription 3	Mus musculus	129-134
34341336-5	2021	PLA enhanced FGFBP1 expression through activation of the mechanistic target of rapamycin complex 1-signal transducer and activator of transcription 3 (mTORC1-STAT3) signaling pathway.	Sirolimus	79-88	signal transducer and activator of transcription 3	Mus musculus	99-149
34341336-5	2021	PLA enhanced FGFBP1 expression through activation of the mechanistic target of rapamycin complex 1-signal transducer and activator of transcription 3 (mTORC1-STAT3) signaling pathway.	Sirolimus	79-88	signal transducer and activator of transcription 3	Mus musculus	158-163
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	yamabudo juice	155-169	signal transducer and activator of transcription 3	Mus musculus	88-93
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	yamabudo juice	155-169	signal transducer and activator of transcription 3	Mus musculus	255-260
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	2,6-dimethoxy-1,4-benzoquinone	173-176	signal transducer and activator of transcription 3	Mus musculus	88-93
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	2,6-dimethoxy-1,4-benzoquinone	173-176	signal transducer and activator of transcription 3	Mus musculus	255-260
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	yamabudo juice	194-208	signal transducer and activator of transcription 3	Mus musculus	88-93
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	yamabudo juice	194-208	signal transducer and activator of transcription 3	Mus musculus	255-260
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	2,6-dimethoxy-1,4-benzoquinone	213-216	signal transducer and activator of transcription 3	Mus musculus	88-93
34087405-10	2021	With or without epidermal growth factor stimulation, phosphorylation of Erk1/2, Akt and Stat3 in A549 cells was significantly decreased in the presence of yamabudo juice or DBQ, indicating that yamabudo juice and DBQ suppressed PI3K/AKT, MAPK/ERK and JAK/STAT3 signaling pathways.	2,6-dimethoxy-1,4-benzoquinone	213-216	signal transducer and activator of transcription 3	Mus musculus	255-260
34278452-9	2021	The expression levels of PD-L1, MGMT and STAT3 were significantly increased in GC tissues, GC cells and cisplatin-resistant cells.	Cisplatin	104-113	signal transducer and activator of transcription 3	Mus musculus	41-46
34333214-8	2021	Molecular docking results showed that 3-O-feruloylquinic acid has good conjugation with Bcl-2, Stat3, mTOR, and mmp9.	3-O-Feruloylquinic acid	38-61	signal transducer and activator of transcription 3	Mus musculus	95-100
34452929-0	2021	Self-assembly nanovaccine containing TLR7/8 agonist and STAT3 inhibitor enhances tumor immunotherapy by augmenting tumor-specific immune response.	nanovaccine	14-25	signal transducer and activator of transcription 3	Mus musculus	56-61
34452929-5	2021	METHODS: A Self-assembling Vehicle-free Multi-component Antitumor nanoVaccine (SVMAV) was constructed by using an unsaturated fatty acid docosahexaenoic acid (DHA)-conjugated antigen and R848 (a Toll-like receptor 7/8 agonist) to encapsulate stattic (a signal transducer and activator of transcription 3 inhibitor).	nanovaccine	66-77	signal transducer and activator of transcription 3	Mus musculus	253-303
34320467-12	2021	In conclusion, fraxetin enhances the anti-tumor activity of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.	gemcitabine	60-71	signal transducer and activator of transcription 3	Mus musculus	133-138
34316030-7	2022	Mechanistically, antibody array and bioinformatic analysis showed that the pathways related to IL-17 secretion, including JAK-STAT pathway, Th17 differentiation, and IL-17 pathway, might be involved in the treatment of silicosis by pirfenidone.	pirfenidone	232-243	signal transducer and activator of transcription 3	Mus musculus	126-130
34315511-7	2021	STAT3 activation was inhibited using cryptotanshinone (CPT) treatment.	cryptotanshinone	37-53	signal transducer and activator of transcription 3	Mus musculus	0-5
34315511-7	2021	STAT3 activation was inhibited using cryptotanshinone (CPT) treatment.	cryptotanshinone	55-58	signal transducer and activator of transcription 3	Mus musculus	0-5
34316030-8	2022	Further in vivo experiments confirmed that pirfenidone reduced the production of IL-17A induced by silica exposure via inhibiting STAT3 phosphorylation.	pirfenidone	43-54	signal transducer and activator of transcription 3	Mus musculus	130-135
34316030-8	2022	Further in vivo experiments confirmed that pirfenidone reduced the production of IL-17A induced by silica exposure via inhibiting STAT3 phosphorylation.	Silicon Dioxide	99-105	signal transducer and activator of transcription 3	Mus musculus	130-135
34440089-8	2021	Furthermore, the nuclear translocation STAT1 and STAT3 heterodimers were markedly diminished by ruxolitinib treatment, possibly resulting in decreased ALDH1A3 activation.	ruxolitinib	96-107	signal transducer and activator of transcription 3	Mus musculus	49-54
34227806-0	2021	Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2.	epigallocatechin gallate	20-24	signal transducer and activator of transcription 3	Mus musculus	84-89
34175886-0	2021	Dexamethasone suppresses immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways.	Dexamethasone	0-13	signal transducer and activator of transcription 3	Mus musculus	55-60
34175886-12	2021	Mechanism study shows dexamethasone mediated transcriptional suppression of PD-L1 and IDO1 depends on the nuclear translocation of GR/STAT3 complex.	Dexamethasone	22-35	signal transducer and activator of transcription 3	Mus musculus	134-139
34175886-13	2021	These findings demonstrate dexamethasone can suppress immune evasion by inducing GR/STAT3 mediated downregulation of PD-L1 and IDO1 pathways.	Dexamethasone	27-40	signal transducer and activator of transcription 3	Mus musculus	84-89
34367186-2	2021	Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces inflammatory responses via the JAK2/STAT3 pathway.	ruxolitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	99-104
34367186-2	2021	Ruxolitinib (Rux), a selective oral JAK 1/2 inhibitor, reduces inflammatory responses via the JAK2/STAT3 pathway.	ruxolitinib	13-16	signal transducer and activator of transcription 3	Mus musculus	99-104
34367186-14	2021	Furthermore, Rux administration inhibited the expression of proinflammatory cytokines, including TNF-alpha, IFN-gamma, HMGB1, IL-1beta, IL-2, and IL-6, suggesting that Rux may alleviate IS injury by inhibiting proinflammatory reactions via JAK2/STAT3 signaling pathway regulation.	ruxolitinib	13-16	signal transducer and activator of transcription 3	Mus musculus	245-250
34367186-17	2021	Rux application suppressed lipopolysaccharide (LPS)-induced NLRP3 inflammasome secretion and JAK2/STAT3 pathway activation in the OGD/R model in vitro.	ruxolitinib	0-3	signal transducer and activator of transcription 3	Mus musculus	98-103
34227806-10	2021	The signaling of STAT3-BATF2-c-JUN/ATF2-IL-23 has been further verified in RAW264.7 macrophages using the STAT3 inhibitor of AG490 and the activator of Colivelin TFA.	COLIVELIN	152-165	signal transducer and activator of transcription 3	Mus musculus	17-22
34227806-11	2021	The results indicated that EGCG inhibits the phosphorylation of STAT3 to facilitate the decreased level of BATF2, which contributed to the increased level of IL-23 by the enhancing heterodimerization of c-JUN and ATF2.	epigallocatechin gallate	27-31	signal transducer and activator of transcription 3	Mus musculus	64-69
34267347-8	2022	Furthermore, administration of WZ-2-033 in vivo induced a significant antitumor response in mouse models of TNBC and gastric cancer that correlated with the inhibition of constitutively active STAT3 and the suppression of known STAT3 downstream genes.	wz-2-033	31-39	signal transducer and activator of transcription 3	Mus musculus	193-198
34349652-3	2021	In CoCl2-treated L929 cells, KX-01 significantly reduced the expression of smooth muscle actin (alpha-SMA), collagen I, collagen III, hypoxia inducing factor (HIF-1alpha), signal transducers and transcriptional activators (p-STAT3), and p-Src.	cobaltous chloride	3-8	signal transducer and activator of transcription 3	Mus musculus	225-230
34261799-4	2021	Using NF2 mouse models, we found that losartan treatment normalized the TME by (i) reducing neuroinflammatory IL-6/STAT3 signaling and preventing hearing loss, (ii) normalizing tumor vasculature and alleviating neuro-edema, and (iii) increasing oxygen delivery and enhancing efficacy of radiation therapy.	Losartan	38-46	signal transducer and activator of transcription 3	Mus musculus	115-120
34246283-13	2021	Administration of Stattic, a STAT3 phosphorylation inhibitor, rescued the number of astrocyte-neuron interactions in 5XFAD mice.	stattic	18-25	signal transducer and activator of transcription 3	Mus musculus	29-34
34381810-0	2021	Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation.	malic acid	0-6	signal transducer and activator of transcription 3	Mus musculus	111-116
34381810-0	2021	Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation.	Aspartic Acid	7-16	signal transducer and activator of transcription 3	Mus musculus	111-116
34381810-8	2021	Our study has further suggested that AOAA produced inhibition of LPS-induced microglial activation at least partially by decreasing STAT3 phosphorylation.	Aminooxyacetic Acid	37-41	signal transducer and activator of transcription 3	Mus musculus	132-137
34269008-4	2021	Results indicated that EGCG and metformin exhibited a synergistic effect on cell viability, migration, and proliferation, as well as signal transducer and activator of transcription 3/nuclear factor-kappaB (STAT3/NF-kappaB) pathway signaling and the production of inflammation cytokines.	epigallocatechin gallate	23-27	signal transducer and activator of transcription 3	Mus musculus	207-212
34269008-4	2021	Results indicated that EGCG and metformin exhibited a synergistic effect on cell viability, migration, and proliferation, as well as signal transducer and activator of transcription 3/nuclear factor-kappaB (STAT3/NF-kappaB) pathway signaling and the production of inflammation cytokines.	Metformin	32-41	signal transducer and activator of transcription 3	Mus musculus	207-212
34307396-12	2021	Importantly, the top 30 DEGs under EAP in the Stat5-cKO mice were enriched in the IL-6/STAT3 signaling pathway.	phosphorylethanolamine	35-38	signal transducer and activator of transcription 3	Mus musculus	87-92
34307396-14	2021	Additionally, we found that EAP could activate STAT3 signaling in the absence of the Stat5 gene, and could also activate antiapoptotic, survival, and anti-inflammatory signaling pathways.	phosphorylethanolamine	28-31	signal transducer and activator of transcription 3	Mus musculus	47-52
34189758-0	2022	Loganin exerts a protective effect on ischemia-reperfusion-induced acute kidney injury by regulating JAK2/STAT3 and Nrf2/HO-1 signaling pathways.	loganin	0-7	signal transducer and activator of transcription 3	Mus musculus	106-111
34189758-8	2022	Loganin down-regulated the expression of apoptosis-related proteins, suppressed JAK2/STAT3 pathway, and activated Nrf2/HO-1 pathway.	loganin	0-7	signal transducer and activator of transcription 3	Mus musculus	85-90
34267347-8	2022	Furthermore, administration of WZ-2-033 in vivo induced a significant antitumor response in mouse models of TNBC and gastric cancer that correlated with the inhibition of constitutively active STAT3 and the suppression of known STAT3 downstream genes.	wz-2-033	31-39	signal transducer and activator of transcription 3	Mus musculus	228-233
34147124-14	2021	Mechanistically, DHM-induced IFN-gamma expression was through AhR-NF-kappaB/STAT3 pathway in NK cells.	dihydromyricetin	17-20	signal transducer and activator of transcription 3	Mus musculus	76-81
34262465-8	2021	By using STAT3 knockdown AML12 cells, we showed that TLR9-mediated STAT3 activation inhibited ATF6-CHOP signaling cascade and thereby protecting against acetaldehyde-induced mitochondrial dysfunction and cell injury.	Acetaldehyde	153-165	signal transducer and activator of transcription 3	Mus musculus	9-14
34262465-8	2021	By using STAT3 knockdown AML12 cells, we showed that TLR9-mediated STAT3 activation inhibited ATF6-CHOP signaling cascade and thereby protecting against acetaldehyde-induced mitochondrial dysfunction and cell injury.	Acetaldehyde	153-165	signal transducer and activator of transcription 3	Mus musculus	67-72
34202301-7	2021	In addition, alantolactone was found to inhibit STAT3 phosphorylation and NF-kappaB p65 nuclear translocation in HaCaT keratinocytes.	alantolactone	13-26	signal transducer and activator of transcription 3	Mus musculus	48-53
34257825-10	2021	Further, we demonstrated melatonin-mediated MT2 weakened GR feedback, suppressed oxidative stress, restored the intestinal microbiota and its metabolites homeostasis, and inactivated the STAT3/AP-1/NF-kappaB pathway-induced inflammatory response in vivo and in vitro.	Melatonin	25-34	signal transducer and activator of transcription 3	Mus musculus	187-192
34194542-11	2021	Mechanistic studies revealed that sodium lactate enhanced the expression of P-STAT3.	Sodium Lactate	34-48	signal transducer and activator of transcription 3	Mus musculus	78-83
34206429-0	2021	Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing-Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice.	stattic	39-46	signal transducer and activator of transcription 3	Mus musculus	30-35
34177920-7	2021	Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins.	Fatty Acids, Volatile	87-91	signal transducer and activator of transcription 3	Mus musculus	250-255
34177920-7	2021	Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins.	Butyrates	93-101	signal transducer and activator of transcription 3	Mus musculus	250-255
34177920-7	2021	Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins.	Propionates	103-113	signal transducer and activator of transcription 3	Mus musculus	250-255
34177920-7	2021	Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins.	Acetates	118-125	signal transducer and activator of transcription 3	Mus musculus	250-255
34177920-7	2021	Organoid culture of small intestinal crypts revealed that the short chain fatty acids (SCFA) butyrate, propionate and acetate, fermentation products of inulin, induce Paneth cell alpha-defensin expression in vitro, and that histone deacetylation and STAT3 might play a role in butyrate-mediated induction of alpha-defensins.	Butyrates	277-285	signal transducer and activator of transcription 3	Mus musculus	250-255
34103688-5	2022	Furthermore, 8-O-cAMP administration restored CCAAT/enhancer binding protein beta (C/EBP-beta) expression and further upregulated the expression of Suppressor of cytokine signaling 3 (SOCS3), while inhibiting p-STAT3, MCP-1, IL-6, and TNF-alpha expression in the kidney cortex in db/db mice.	8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate	13-21	signal transducer and activator of transcription 3	Mus musculus	211-216
34103688-10	2022	These findings indicate that Epac activation via 8-O-cAMP ameliorates tubulointerstitial inflammation in DN through the C/EBP-beta/SOCS3/STAT3 pathway.	8-(4-chloro-phenylthio)-2'-O-methyladenosine-3'-5'-cyclic monophosphate	49-57	signal transducer and activator of transcription 3	Mus musculus	137-142
34194542-12	2021	Furthermore, a STAT3 inhibitor eliminated sodium lactate-mediated promotion macrophage polarization.	Sodium Lactate	42-56	signal transducer and activator of transcription 3	Mus musculus	15-20
34194542-13	2021	Conclusion: Sodium lactate facilitates anti-inflammatory M2 macrophage polarization and protects against MI by regulating P-STAT3.	Sodium Lactate	12-26	signal transducer and activator of transcription 3	Mus musculus	124-129
34092294-0	2021	Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-kappaB and STAT1/STAT3 signaling.	esculetin	0-9	signal transducer and activator of transcription 3	Mus musculus	103-108
34092294-5	2021	Of note, activation of NF-kappaB and STAT1/STAT3 signals, the main upstream signals of many inflammatory factors, were attenuated by esculetin in both lung tissues from septic mice and LPS-stimulated macrophage.	esculetin	133-142	signal transducer and activator of transcription 3	Mus musculus	43-48
34092294-6	2021	These findings suggested that the protection of esculetin against early sepsis should be related to its anti-inflammatory effect, which was at least partly due to its inhibition on NF-kappaB and STAT1/STAT3 signaling pathway in macrophage.	esculetin	48-57	signal transducer and activator of transcription 3	Mus musculus	201-206
34077834-0	2021	Rosmarinic acid represses colitis-associated colon cancer: A pivotal involvement of the TLR4-mediated NF-kappaB-STAT3 axis.	rosmarinic acid	0-15	signal transducer and activator of transcription 3	Mus musculus	112-117
34077834-8	2021	Thus, RA suppressed NF-kappaB and STAT3 activation in colon cancer cells in an inflammatory microenvironment.	rosmarinic acid	6-8	signal transducer and activator of transcription 3	Mus musculus	34-39
34075160-0	2021	Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2-STAT3 pathway.	daphnetin	0-9	signal transducer and activator of transcription 3	Mus musculus	102-107
34194525-0	2021	Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in OVA-Stimulated Asthma in Mice.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	64-69
34071363-6	2021	The anti-inflammatory effect of TauCl was associated with inhibition of STAT3 activation and induction of antioxidant enzymes, such as heme oxygenase-1 and NAD(P)H:quinone oxidoreductase 1, through activation of nuclear factor erythroid 2-related factor 2.	N-chlorotaurine	32-37	signal transducer and activator of transcription 3	Mus musculus	72-77
34072430-7	2021	AUY-922 suppressed the LPS-induced inflammation by inhibiting major pro-inflammatory pathways (e.g., JAK2/STAT3, MAPKs), and downregulated the IL-1beta, IL-6, MCP-1 and TNFalpha.	5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide	0-7	signal transducer and activator of transcription 3	Mus musculus	106-111
34075160-7	2021	Moreover, SAP-induced phosphorylation of JAK2 and STAT3 in the lung tissue was also significantly diminished by the daphnetin pretreatment.	BENSULIDE	10-13	signal transducer and activator of transcription 3	Mus musculus	50-55
34075160-7	2021	Moreover, SAP-induced phosphorylation of JAK2 and STAT3 in the lung tissue was also significantly diminished by the daphnetin pretreatment.	daphnetin	116-125	signal transducer and activator of transcription 3	Mus musculus	50-55
34075160-8	2021	These results indicated that daphnetin reduces SAP-associated lung tissue damage, likely by inhibiting the activation of JAK2-STAT3 signalling.	daphnetin	29-38	signal transducer and activator of transcription 3	Mus musculus	126-131
34122447-4	2021	Interestingly, sorafenib altered the LPS-mediated neuroinflammatory response in BV2 microglial cells by modulating AKT/P38-linked STAT3/NF-kB signaling pathways.	Sorafenib	15-24	signal transducer and activator of transcription 3	Mus musculus	130-135
34093025-0	2021	Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling.	Acetone	0-7	signal transducer and activator of transcription 3	Mus musculus	89-94
34094954-22	2021	Conclusions: Our study reveals that LINC00467 promotes prostate cancer progression via M2 macrophage polarization and the miR-494-3p/STAT3 axis.	linc00467	36-45	signal transducer and activator of transcription 3	Mus musculus	133-138
34079330-6	2021	Similarly, plasma IL-6 levels in ALL, ALL-tocilizumab (TCZ, an IL-6 receptor inhibitor) and ALL-S3I-201 (a selective inhibitor of STAT3) mice were increased compared to the control group.	s3i	96-99	signal transducer and activator of transcription 3	Mus musculus	130-135
34150002-0	2021	STAT3-mediated effects of methyltransferase inhibitor 5-aza-2"-deoxycytidine on preeclampsia.	Decitabine	54-76	signal transducer and activator of transcription 3	Mus musculus	0-5
34150002-1	2021	OBJECTIVE: To investigate the effects of 5-aza-2"-deoxycytidine (5-AZA-DC) on preeclampsia (PE) and functional mechanisms dependent on STAT3.	Decitabine	41-63	signal transducer and activator of transcription 3	Mus musculus	135-140
34150002-13	2021	DNMT1 was increased while STAT3, PTEN and TSC2 were decreased by 5-AZA-DC.	Azacitidine	65-70	signal transducer and activator of transcription 3	Mus musculus	26-31
34150002-15	2021	PE-induced STAT3 down-regulation was restored by 5-AZA-DC.	Azacitidine	49-54	signal transducer and activator of transcription 3	Mus musculus	11-16
34063048-5	2021	Furthermore, pazopanib inhibited not only expression of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and perilipin A but also phosphorylation of signal transducer and activator of transcription (STAT)-3 during 3T3-L1 preadipocyte differentiation.	pazopanib	13-22	signal transducer and activator of transcription 3	Mus musculus	215-272
34093866-14	2021	ORY1001 treatment rescued expression of reactive astrogliosis-linked genes in HMG20A ablated astrocytes while enhancing cell surface area, GFAP intensity and STAT3 expression in healthy astrocytes, mimicking the effect of HMG20A.	Iadademstat	0-7	signal transducer and activator of transcription 3	Mus musculus	158-163
34063048-9	2021	In summary, this is the first report that pazopanib has strong anti-adipogenic and anti-inflammatory effects in 3T3-L1 cells, which are mediated through regulation of the expression and phosphorylation of C/EBP-alpha, PPAR-gamma, STAT-3, ACC, perilipin A, AMPK, and COX-2.	pazopanib	42-51	signal transducer and activator of transcription 3	Mus musculus	230-236
34435054-15	2021	Conclusions: The results of this study suggest that ATZ effectively promotes the proliferation and metastasis of EOC cells through the Stat3 signaling pathway by inducing low levels of ROS.	Atrazine	52-55	signal transducer and activator of transcription 3	Mus musculus	135-140
35403732-6	2022	Administration of fexofenadine, a histamine H1 receptor antagonist, suppressed tumor growth in HFD-fed mice by reducing the number of myeloid-derived suppressor cells and suppressing IL6/STAT3 signaling.	fexofenadine	18-30	signal transducer and activator of transcription 3	Mus musculus	187-192
35584053-0	2022	Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance.	Doxorubicin	25-36	signal transducer and activator of transcription 3	Mus musculus	145-150
35584053-1	2022	The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling.	Ritonavir	37-46	signal transducer and activator of transcription 3	Mus musculus	201-206
35584053-1	2022	The derivative of protease inhibitor ritonavir (5-methyl-4-oxohexanoic acid ritonavir ester; RD) was recently recognized as a potent P-gp inhibitor and cancerostatic drug inhibiting the proteasome and STAT3 signaling.	5-methyl-4-oxohexanoic acid ritonavir ester	48-91	signal transducer and activator of transcription 3	Mus musculus	201-206
35584053-5	2022	Star-RD + Dox efficiently inhibited STAT3 signaling and induced caspase-3 activation and DNA fragmentation in cancer cells in vivo.	Doxorubicin	10-13	signal transducer and activator of transcription 3	Mus musculus	36-41
35397421-7	2022	AG490-mediated inhibition of the JAK2/STAT3 pathway before irradiation significantly reduced the expression of p-JAK2 and p-STAT3 in lung cancer cells, in the meantime, expression of CD47 and PD-L1 was also reduced.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	38-43
35397421-7	2022	AG490-mediated inhibition of the JAK2/STAT3 pathway before irradiation significantly reduced the expression of p-JAK2 and p-STAT3 in lung cancer cells, in the meantime, expression of CD47 and PD-L1 was also reduced.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	124-129
35359221-6	2022	The results from cultured cardiomyocytes also proved that sRAGE attenuated myocardial apoptosis and autophagy through interacting with integrinbeta3 to activate Akt and STAT3 pathway during oxygen and glucose deprivation/reperfusion (OGD/R) treatment.	Oxygen	190-196	signal transducer and activator of transcription 3	Mus musculus	169-174
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	signal transducer and activator of transcription 3	Mus musculus	36-41
35359221-7	2022	Furthermore, the phosphorylation of STAT3 was significantly downregulated by the inhibition of Akt (LY294002, 10 muM) in OGD/R and sRAGE treated cardiomyocytes, which suggested that STAT3 pathway was induced by Akt in I/R and sRAGE treated cardiomyocytes.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	100-108	signal transducer and activator of transcription 3	Mus musculus	182-187
34193173-10	2021	Daily intraperitoneal injection of high-glucose based dialysis fluid (HG-PDF) induced peritoneal fibrosis in the mice, accompanied by the phosphorylation of STAT3.	Glucose	40-47	signal transducer and activator of transcription 3	Mus musculus	157-162
34193173-14	2021	It provided the first evidence that pharmacological inhibition of STAT3 signaling attenuated high glucose-mediated mesothelial cells EMT as well as peritoneal fibrosis.	Glucose	98-105	signal transducer and activator of transcription 3	Mus musculus	66-71
34662222-12	2021	Furthermore, FTY720 treatment up-regulated the expression level of M2 biomarker CD206, Arg-1, Fizz-1, which could be weakened by the STAT3 inhibitor.	Fingolimod Hydrochloride	13-19	signal transducer and activator of transcription 3	Mus musculus	133-138
34515136-0	2021	Jak1/Stat3 Activation Alters Phosphate Metabolism Independently of Sex and Extracellular Phosphate Levels.	Phosphates	29-38	signal transducer and activator of transcription 3	Mus musculus	5-10
34515136-2	2021	Previously, we showed that activation of the Janus kinase 1 (Jak1)-signal transducer and activator of transcription 3 (Stat3) signaling pathway leads to altered mineral metabolism with higher FGF23 levels, lower PTH, and higher calcitriol levels.	Calcitriol	228-238	signal transducer and activator of transcription 3	Mus musculus	67-117
34515136-2	2021	Previously, we showed that activation of the Janus kinase 1 (Jak1)-signal transducer and activator of transcription 3 (Stat3) signaling pathway leads to altered mineral metabolism with higher FGF23 levels, lower PTH, and higher calcitriol levels.	Calcitriol	228-238	signal transducer and activator of transcription 3	Mus musculus	119-124
35576655-0	2022	Discovery of diarylheptanoids that activate alpha7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.	Diarylheptanoids	13-29	signal transducer and activator of transcription 3	Mus musculus	62-67
35576655-10	2022	Collectively, our findings have identified a new diarylheptanoid, compound 28, as an agonist of alpha7 nAchR-JAK2-STAT3 signaling, which can be potentially developed as a valuable candidate for the treatment of sepsis, and provide a new lead structure for the development of anti-inflammatory agents targeting alpha7 nAchR-JAK2-STAT3 signaling.	Diarylheptanoids	49-64	signal transducer and activator of transcription 3	Mus musculus	114-119
35513105-0	2022	Pine pollen polysaccharides promote cell proliferation and accelerate wound healing by activating the JAK2-STAT3 signaling pathway.	pine pollen polysaccharides	0-27	signal transducer and activator of transcription 3	Mus musculus	107-112
35060126-10	2022	Mechanically, Reg3g increased accumulation of pSTAT3(Ser727) in mitochondria by activating ERK1/2-STAT3 signaling pathway, leading to restoration of Tac-induced mitochondrial impairment.	Tacrolimus	149-152	signal transducer and activator of transcription 3	Mus musculus	98-103
35514302-10	2022	Taken together, these findings demonstrate that the prophylactic administration of IL-27 ameliorates asthma by alleviating the lung Th2 inflammatory environment through the restoration of both the STAT1 and STAT3 pathways.	th2	132-135	signal transducer and activator of transcription 3	Mus musculus	207-212
34655303-7	2022	These compounds also suppressed STAT3 activation in HMDMs stimulated by IL-10 and TCS, whereas these compounds had no effect on STAT3 activation in tumor cells.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	82-85	signal transducer and activator of transcription 3	Mus musculus	32-37
35313341-6	2022	Cediranib-resistant tumors had intrinsically high levels of IL-6 and JAK/STAT signaling and treatment increased endothelial STAT3 activation.	cediranib	0-9	signal transducer and activator of transcription 3	Mus musculus	73-77
35313341-6	2022	Cediranib-resistant tumors had intrinsically high levels of IL-6 and JAK/STAT signaling and treatment increased endothelial STAT3 activation.	cediranib	0-9	signal transducer and activator of transcription 3	Mus musculus	124-129
35313341-8	2022	In a third HGSOC model, that had lower inherent IL-6 JAK/STAT3 signaling in the TME but high PD1 signaling, long-term cediranib treatment significantly increased overall survival.	cediranib	118-127	signal transducer and activator of transcription 3	Mus musculus	57-62
35597815-2	2022	We herein demonstrated that YHIEPV, derived from the pepsin-pancreatin digestion of the green leaf protein Rubisco, increased the leptin-induced phosphorylation of STAT3 in ex vivo hypothalamic slice cultures.	yhiepv	28-34	signal transducer and activator of transcription 3	Mus musculus	164-169
35430461-9	2022	In the presence of estrogen plus progesterone, treatment with ESCs with anti-IL-27 inhibited the activation of STAT3.	Progesterone	33-45	signal transducer and activator of transcription 3	Mus musculus	111-116
35452800-0	2022	Daphnetin ameliorates Abeta pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer"s disease.	daphnetin	0-9	signal transducer and activator of transcription 3	Mus musculus	45-50
35452800-7	2022	Interestingly, daphnetin markedly decreased the expression of glial fibrillary acidic protein (GFAP) and the upstream regulatory molecule- phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in APP/PS1 mice, and mainly inhibited the phosphorylation of STAT3 at Ser727 to decrease GFAP expression evidenced in a LPS-activated glial cell model.	daphnetin	15-24	signal transducer and activator of transcription 3	Mus musculus	154-204
35452800-7	2022	Interestingly, daphnetin markedly decreased the expression of glial fibrillary acidic protein (GFAP) and the upstream regulatory molecule- phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in APP/PS1 mice, and mainly inhibited the phosphorylation of STAT3 at Ser727 to decrease GFAP expression evidenced in a LPS-activated glial cell model.	daphnetin	15-24	signal transducer and activator of transcription 3	Mus musculus	208-213
35452800-7	2022	Interestingly, daphnetin markedly decreased the expression of glial fibrillary acidic protein (GFAP) and the upstream regulatory molecule- phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in APP/PS1 mice, and mainly inhibited the phosphorylation of STAT3 at Ser727 to decrease GFAP expression evidenced in a LPS-activated glial cell model.	daphnetin	15-24	signal transducer and activator of transcription 3	Mus musculus	276-281
35606804-0	2022	Naringenin and cryptotanshinone shift the immune response towards Th1 and modulate T regulatory cells via JAK2/STAT3 pathway in breast cancer.	naringenin	0-10	signal transducer and activator of transcription 3	Mus musculus	111-116
35606804-0	2022	Naringenin and cryptotanshinone shift the immune response towards Th1 and modulate T regulatory cells via JAK2/STAT3 pathway in breast cancer.	cryptotanshinone	15-31	signal transducer and activator of transcription 3	Mus musculus	111-116
35606804-7	2022	RESULTS: We showed higher DTH, increased lymphocyte proliferation, decreased tumor growth and reduced JAK2/STAT3 phosphorylation in mice treated with naringenin and CPT.	naringenin	150-160	signal transducer and activator of transcription 3	Mus musculus	107-112
35599279-10	2022	In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction.	Streptozocin	3-6	signal transducer and activator of transcription 3	Mus musculus	73-78
35574904-6	2022	The effects of pinocembrin on morphine induced microglial activation, neuroinflammation, and STAT3 activation were determined by Iba1 immunostaining, Il1b and Tnfa mRNA levels and STAT3 phosphorylation.	Morphine	30-38	signal transducer and activator of transcription 3	Mus musculus	93-98
35593989-7	2022	In vitro, alpha5-nAChR mediated nicotine-induced PD-L1 expression via STAT3 and the expression of EMT markers.	Nicotine	32-40	signal transducer and activator of transcription 3	Mus musculus	70-75
35581445-12	2022	EMPA and DAPA treatment led to NF-kB, RISK, STAT-3 activation and the downstream apoptosis reduction coinciding with IS reduction.	empagliflozin	0-4	signal transducer and activator of transcription 3	Mus musculus	44-50
35581445-12	2022	EMPA and DAPA treatment led to NF-kB, RISK, STAT-3 activation and the downstream apoptosis reduction coinciding with IS reduction.	dapagliflozin	9-13	signal transducer and activator of transcription 3	Mus musculus	44-50
35574904-10	2022	Our results reveal a strong connection of STAT3 with morphine tolerance and pinocembrin suppressed morphine-induced STAT3 activation both in vivo and in BV2 cells.	Morphine	53-61	signal transducer and activator of transcription 3	Mus musculus	42-47
35574904-10	2022	Our results reveal a strong connection of STAT3 with morphine tolerance and pinocembrin suppressed morphine-induced STAT3 activation both in vivo and in BV2 cells.	Morphine	99-107	signal transducer and activator of transcription 3	Mus musculus	116-121
35574904-11	2022	Finally, we show that STAT3 inhibition is sufficient to suppress morphine tolerance and hyperalgesia.	Morphine	65-73	signal transducer and activator of transcription 3	Mus musculus	22-27
35543945-0	2022	(Effect of fire needling on imiquimod induced psoriasis-like lesion and STAT3 pathway in mice).	Imiquimod	28-37	signal transducer and activator of transcription 3	Mus musculus	72-77
35567856-6	2022	Hypertensive mice were treated with recombinant IL-22 (rIL-22), anti-IL-22 antibody, or JAK2/STAT3 pathway blocker AG-490 respectively.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	115-121	signal transducer and activator of transcription 3	Mus musculus	93-98
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	signal transducer and activator of transcription 3	Mus musculus	146-151
35537703-6	2022	Our results showed that RA-XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p-STAT3, P70S6K, NF-kappaB and GSK3beta and suppressed the expression of LC3A/B in HCT116 cells in co-culture system.	Radium	24-26	signal transducer and activator of transcription 3	Mus musculus	154-159
35551922-6	2022	Topical application of the pan-FGFR inhibitor AZD4547 to mouse skin prior to exposure to UVB significantly inhibited FGFR phosphorylation as well as mTORC1, STAT3 and MAPK activation (i.e., phosphorylation).	AZD4547	46-53	signal transducer and activator of transcription 3	Mus musculus	157-162
35543945-20	2022	CONCLUSION: Fire needling therapy improves skin lesion severity in imiquimod induced psoriasis-like lesion of the mice, which is probably related to the inhibition of STAT3 pathway activation and the decrease of Th17 inflammatory factors expression.	Imiquimod	67-76	signal transducer and activator of transcription 3	Mus musculus	167-172
35302173-0	2022	FTY720 attenuates APAP-induced liver injury via the JAK2/STAT3 signaling pathway.	Fingolimod Hydrochloride	0-6	signal transducer and activator of transcription 3	Mus musculus	57-62
35503759-14	2022	We investigated the effect of radotinib on the STAT3 signaling pathway in MM cells, including several MM cell lines and mouse models.	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-pyrazin-2-ylpyrimidin-2-ylamino)benzamide	30-39	signal transducer and activator of transcription 3	Mus musculus	47-52
35585990-0	2022	MicroRNA-382 Promotes M2-Like Macrophage via the SIRP-alpha/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis.	aristolochic acid I	87-104	signal transducer and activator of transcription 3	Mus musculus	60-65
35285172-7	2022	Moreover, the bile reflux induced gastric precancerous lesions observed in the post BR surgery mice can be prevented by treatment with cryptotanshinone, a plant-derived STAT3 inhibitor.	cryptotanshinone	135-151	signal transducer and activator of transcription 3	Mus musculus	169-174
35609321-0	2022	Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway.	pirfenidone	0-11	signal transducer and activator of transcription 3	Mus musculus	97-171
35609321-0	2022	Pirfenidone attenuates cardiac hypertrophy against isoproterenol by inhibiting activation of the janus tyrosine kinase-2/signal transducer and activator of transcription 3 (JAK-2/STAT3) signaling pathway.	pirfenidone	0-11	signal transducer and activator of transcription 3	Mus musculus	179-184
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	iso	101-104	signal transducer and activator of transcription 3	Mus musculus	62-67
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	iso	101-104	signal transducer and activator of transcription 3	Mus musculus	68-74
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	pirfenidone	153-164	signal transducer and activator of transcription 3	Mus musculus	62-67
35609321-7	2022	Lastly, the promoted expression levels of p-JAK-2/JAK-2 and p-STAT3/STAT-3 in the cardiac tissues of ISO-challenged mice were significantly repressed by Pirfenidone or SPI.	pirfenidone	153-164	signal transducer and activator of transcription 3	Mus musculus	68-74
35124416-7	2022	Results showed that 0.1 mug/L quinolone antibiotics activated the key proteins in the PI3K/Akt, Notch1, JNK and JAK2/STAT3 signaling pathways to cause the secretion of pro-inflammatory cytokines and induce inflammation.	Quinolones	30-39	signal transducer and activator of transcription 3	Mus musculus	117-122
35302173-0	2022	FTY720 attenuates APAP-induced liver injury via the JAK2/STAT3 signaling pathway.	Acetaminophen	18-22	signal transducer and activator of transcription 3	Mus musculus	57-62
35302173-17	2022	Inhibition of JAK2/STAT3 signaling attenuated the protective, antioxidant effects of FTY720.	Fingolimod Hydrochloride	85-91	signal transducer and activator of transcription 3	Mus musculus	19-24
35600776-2	2022	STAT3 signaling has been implicated in sorafenib resistance.	Sorafenib	39-48	signal transducer and activator of transcription 3	Mus musculus	0-5
35600776-3	2022	Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells.	Artesunate	0-10	signal transducer and activator of transcription 3	Mus musculus	92-97
35600776-3	2022	Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells.	Artesunate	12-15	signal transducer and activator of transcription 3	Mus musculus	92-97
35600776-3	2022	Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells.	ginsenoside Rg3	21-42	signal transducer and activator of transcription 3	Mus musculus	92-97
35600776-3	2022	Artesunate (ART) and 20(R)-ginsenoside Rg3 (Rg3) have anti-hepatoma effects and can inhibit STAT3 signaling in cancer cells.	ginsenoside Rg3	44-47	signal transducer and activator of transcription 3	Mus musculus	92-97
35600776-11	2022	Mechanistic studies revealed that Rg3-plus-ART inhibited activation/phosphorylation of Src and STAT3 in HepG2-SR cultures and tumors.	ginsenoside Rg3	34-37	signal transducer and activator of transcription 3	Mus musculus	95-100
35600776-13	2022	Furthermore, over-activation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, and removal of ROS diminished Rg3-plus-ART"s inhibitory effects on STAT3 activation in HepG2-SR cells.	ros	130-133	signal transducer and activator of transcription 3	Mus musculus	182-187
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	ginsenoside Rg3	13-16	signal transducer and activator of transcription 3	Mus musculus	103-108
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	ginsenoside Rg3	13-16	signal transducer and activator of transcription 3	Mus musculus	141-146
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	Artesunate	22-25	signal transducer and activator of transcription 3	Mus musculus	103-108
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	Artesunate	22-25	signal transducer and activator of transcription 3	Mus musculus	141-146
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	Sorafenib	36-45	signal transducer and activator of transcription 3	Mus musculus	103-108
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	ros	137-140	signal transducer and activator of transcription 3	Mus musculus	141-146
35157180-5	2022	Furthermore, miR-1278 promoted ASMC proliferation, in which TGF-beta1 played an important role by regulating the SHP-1/STAT3 signaling pathway.	asmc	31-35	signal transducer and activator of transcription 3	Mus musculus	119-124
35305226-3	2022	METHODS AND RESULTS: Using Western blot analysis, immunofluorescence assays and real-time PCR we established the state of STAT3 activation when it comes to the mouse liver subsequent to treatment ofNR1I3 agonist,1,4-bis(2-(3,5-dichloropyridyloxy))benzene (TCPOBOP).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	212-254	signal transducer and activator of transcription 3	Mus musculus	122-127
35305226-3	2022	METHODS AND RESULTS: Using Western blot analysis, immunofluorescence assays and real-time PCR we established the state of STAT3 activation when it comes to the mouse liver subsequent to treatment ofNR1I3 agonist,1,4-bis(2-(3,5-dichloropyridyloxy))benzene (TCPOBOP).	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	256-263	signal transducer and activator of transcription 3	Mus musculus	122-127
35305226-6	2022	CONCLUSIONS: This work"s evidence demonstrates that NR1I3-pushed STAT3 activation contributes to TCPOBOP-induced liver growth and hepatocyte proliferation, at least in part, through its molecular targets cMyc and CyclinD1.	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	97-104	signal transducer and activator of transcription 3	Mus musculus	65-70
35603647-7	2022	Besides, the p-STAT3 and p-NF-kappaB were elevated in CIA mice compared with control group, and H2 treatment significantly inhibited them.	Deuterium	96-98	signal transducer and activator of transcription 3	Mus musculus	15-20
35603647-8	2022	Conclusion H2 can reduce the levels of CD4+IL-22+ cells and IL-22, and alleviate arthritis symptoms in CIA mice by inhibiting STAT3/NF-kappaB pathway.	Deuterium	11-13	signal transducer and activator of transcription 3	Mus musculus	126-131
35571141-0	2022	Suppression of NLRP3 Inflammasome by Dihydroarteannuin via the HIF-1alpha and JAK3/STAT3 Signaling Pathway Contributes to Attenuation of Collagen-Induced Arthritis in Mice.	dihydroarteannuin	37-54	signal transducer and activator of transcription 3	Mus musculus	83-88
35571141-7	2022	Therefore, we concluded that DHA efficiently alleviated the inflammation and arthritic symptoms in CIA mice and downregulated inflammation in part by inhibiting NLRP3 expression via the HIF-1alpha and JAK3/STAT3 signaling pathway.	dihydroarteannuin	29-32	signal transducer and activator of transcription 3	Mus musculus	206-211
35483427-8	2022	Along with the activation of proinflammatory biomarkers (NF-kappaB, STAT3, NLRP3 inflammasome), lung tissue homogenates from mice on an alcohol diet showed overexpression of ACE2 compared with mice on a control diet.	Alcohols	136-143	signal transducer and activator of transcription 3	Mus musculus	68-73
35468892-0	2022	LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP.	linc00858	0-9	signal transducer and activator of transcription 3	Mus musculus	66-73
35218798-5	2022	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) pathways.	psb	13-16	signal transducer and activator of transcription 3	Mus musculus	286-336
35218798-5	2022	In addition, PSB decreased the levels of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-1beta (IL-1beta), IL-6, and IL-18 in the colon and suppressed DSS-induced activation of the nuclear factor kappa B (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) pathways.	psb	13-16	signal transducer and activator of transcription 3	Mus musculus	338-343
35468892-14	2022	In vivo experiments further verified that LINC00858 enhanced the tumorigenicity of colon cancer cells in vivo by regulating the RAD21/PCNP/STAT3/5 axis.	linc00858	42-51	signal transducer and activator of transcription 3	Mus musculus	139-146
35468892-15	2022	It indicated the promoting role of LINC00858 in colon cancer progression though activating PCNP-mediated STAT3/5 pathway by recruiting RAD21.	linc00858	35-44	signal transducer and activator of transcription 3	Mus musculus	105-112
35439335-7	2022	Bendamustine also inhibited phosphorylation of transcriptional factor STAT3, contributing to cell apoptosis and proliferation inhibition.	Bendamustine Hydrochloride	0-12	signal transducer and activator of transcription 3	Mus musculus	70-75
35255002-9	2022	As a mechanism of Dex-induced SOX2 upregulation in preosteoblasts, we found that the STAT3 pathway or GC receptor (GR) is involved using a GR antagonist, STAT3 regulators, and chromatin immunoprecipitation assays.	Dexamethasone	18-21	signal transducer and activator of transcription 3	Mus musculus	85-90
35479835-12	2022	The results suggested that p-Akt, p-STAT3, and p-NF-kappaB were more highly expressed on the inflammatory cells of the prostate derived from the CNP model and were partly suppressed after applying AMD3100 or delivering AAV-shCxcl12, indicating that the CXCL12/CXCR4 axis potentially functioned through AKT/NF-kappaB and STAT3 signaling to influence the pathogenesis of CNP.	plerixafor	197-204	signal transducer and activator of transcription 3	Mus musculus	36-41
35479835-12	2022	The results suggested that p-Akt, p-STAT3, and p-NF-kappaB were more highly expressed on the inflammatory cells of the prostate derived from the CNP model and were partly suppressed after applying AMD3100 or delivering AAV-shCxcl12, indicating that the CXCL12/CXCR4 axis potentially functioned through AKT/NF-kappaB and STAT3 signaling to influence the pathogenesis of CNP.	plerixafor	197-204	signal transducer and activator of transcription 3	Mus musculus	320-325
35439335-10	2022	These findings demonstrate that bendamustine activates DDR pathway, induces the accumulation of intracellularROS level as well as inhibition of STAT3, leading to cell apoptosis and G2/M cell cycle arrest in NKTCL cells, which indicates that bendamustine dramatically suppressed NKTCL both in vitro and in vivo and provides a potential therapeutic strategy in the treatment of NK/T lymphoma.	Bendamustine Hydrochloride	32-44	signal transducer and activator of transcription 3	Mus musculus	144-149
35411090-2	2022	This results in phosphorylation of the Signal Transducer and Activator of Transcription-3 (Stat3) on tyrosine-705, which then dimerizes, migrates to the nucleus, and activates transcription of genes involved in cell division and survival.	Tyrosine	101-109	signal transducer and activator of transcription 3	Mus musculus	39-89
35411090-2	2022	This results in phosphorylation of the Signal Transducer and Activator of Transcription-3 (Stat3) on tyrosine-705, which then dimerizes, migrates to the nucleus, and activates transcription of genes involved in cell division and survival.	Tyrosine	101-109	signal transducer and activator of transcription 3	Mus musculus	91-96
35411090-7	2022	However, expressed to high levels, Src527F eliminates cadherin-11, hence gp130 signaling, thus abolishing Stat3-ptyr705 stimulation.	ptyr705	112-119	signal transducer and activator of transcription 3	Mus musculus	106-111
35384292-0	2022	Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARgamma-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARgamma to STAT3.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	172-177
35351863-0	2022	Alpha-7 nicotinic acetylcholine receptor agonist alleviates psoriasis-like inflammation through inhibition of the STAT3 and NF-kappaB signaling pathway.	Acetylcholine	18-31	signal transducer and activator of transcription 3	Mus musculus	114-119
35410218-10	2022	Moreover, the STAT3 inhibitor cryptotanshinone significantly decreased the B7-H4 protein level in CRC cells.	cryptotanshinone	30-46	signal transducer and activator of transcription 3	Mus musculus	14-19
35114189-14	2022	The nigericin targeting the SRC/STAT3/BCL-2 signaling pathway may provide new insights into the molecular mechanism of nigericin on cancer cells and suggest its possible clinical application in osteosarcoma.	Nigericin	4-13	signal transducer and activator of transcription 3	Mus musculus	32-37
35475457-14	2022	STAT3 activation reversed miR-577-mediated anti-tumor roles.	mir-577	26-33	signal transducer and activator of transcription 3	Mus musculus	0-5
35133054-12	2022	These results, along with our previous data, demonstrate that miR-26 is a tumor suppressor associated with tumor invasion and metastasis of advanced CTCL by regulating the IL-22-STAT3-CCL20 cascade.	mir-26	62-68	signal transducer and activator of transcription 3	Mus musculus	178-183
35501646-4	2022	We also revealed significant changes in the role of JAK and the presence of STAT3 specifics within the framework of JAK/STAT signaling in the production of growth factors by various glial elements under the influence of ethanol.	Ethanol	220-227	signal transducer and activator of transcription 3	Mus musculus	76-81
35501646-4	2022	We also revealed significant changes in the role of JAK and the presence of STAT3 specifics within the framework of JAK/STAT signaling in the production of growth factors by various glial elements under the influence of ethanol.	Ethanol	220-227	signal transducer and activator of transcription 3	Mus musculus	120-124
35230716-7	2022	Using tofacitinib, a clinical JAK inhibitor, the study showed that SM deficiency might participate in STAT3 phosphorylation via JAK activation.	tofacitinib	6-17	signal transducer and activator of transcription 3	Mus musculus	102-107
35557592-0	2022	miRNA-320 inhibits colitis-associated colorectal cancer by regulating the IL-6R/STAT3 pathway in mice.	mirna-320	0-9	signal transducer and activator of transcription 3	Mus musculus	80-85
35557592-16	2022	miRNA-320 significantly inhibited the levels of IL-6R (colon tissue messenger RNA (mRNA): 4.06+-1.44 vs. 10.05+-1.55, t=-6.94, P<0.001), STAT3, and p-STAT3 in vivo and in vitro.	mirna-320	0-9	signal transducer and activator of transcription 3	Mus musculus	137-142
35557592-16	2022	miRNA-320 significantly inhibited the levels of IL-6R (colon tissue messenger RNA (mRNA): 4.06+-1.44 vs. 10.05+-1.55, t=-6.94, P<0.001), STAT3, and p-STAT3 in vivo and in vitro.	mirna-320	0-9	signal transducer and activator of transcription 3	Mus musculus	150-155
35557592-17	2022	Silencing IL-6R expression partially reversed the IL-6R/STAT3-suppressing and tumor-inhibiting effect of miRNA-320.	mirna-320	105-114	signal transducer and activator of transcription 3	Mus musculus	56-61
35557592-18	2022	Conclusions: miRNA-320 inhibits tumorigenesis in mice with CAC by suppressing IL-6R/STAT3 expression, and IL-6R is a target gene of miRNA-320.	mirna-320	13-22	signal transducer and activator of transcription 3	Mus musculus	84-89
34626614-6	2022	Finally, treatment of mice with the pan-Jak inhibitor, tofacitinib, reduced psoriasis-like dermatitis and epidermal STAT3 phosphorylation.	tofacitinib	55-66	signal transducer and activator of transcription 3	Mus musculus	116-121
35462928-17	2022	Cobalt chloride (CoCl2) increased the protein expression of IL-6 and p-STAT3 in AML12 cells.	cobaltous chloride	0-15	signal transducer and activator of transcription 3	Mus musculus	71-76
35462928-17	2022	Cobalt chloride (CoCl2) increased the protein expression of IL-6 and p-STAT3 in AML12 cells.	cobaltous chloride	17-22	signal transducer and activator of transcription 3	Mus musculus	71-76
35414608-0	2022	Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	73-78
35414608-13	2022	Mechanistically, metformin treatment upregulated p-AMPK (phosphorylated AMP-activated protein kinase) and downregulated p-STAT3 (phosphorylated signal transducer and activator of transcription 3) expression in the kidneys.	Metformin	17-26	signal transducer and activator of transcription 3	Mus musculus	122-127
35414608-13	2022	Mechanistically, metformin treatment upregulated p-AMPK (phosphorylated AMP-activated protein kinase) and downregulated p-STAT3 (phosphorylated signal transducer and activator of transcription 3) expression in the kidneys.	Metformin	17-26	signal transducer and activator of transcription 3	Mus musculus	144-194
35414608-15	2022	CONCLUSIONS: Metformin alleviated kidney injury in LN though suppressing renal necroptosis and inflammation via the AMPK/STAT3 pathway.	Metformin	13-22	signal transducer and activator of transcription 3	Mus musculus	121-126
35517401-0	2022	Cucurbitacin I inhibits the proliferation of pancreatic cancer through the JAK2/STAT3 signalling pathway in vivo and in vitro.	cucurbitacin I	0-14	signal transducer and activator of transcription 3	Mus musculus	80-85
35517401-8	2022	Furthermore, the decrease in pancreatic cancer cell proliferation caused by cucurbitacin I appeared to involve JAK2/STAT3 signalling pathway inhibition, and the use of JAK2/STAT3 activators effectively restored the inhibition.	cucurbitacin I	76-90	signal transducer and activator of transcription 3	Mus musculus	116-121
35517401-8	2022	Furthermore, the decrease in pancreatic cancer cell proliferation caused by cucurbitacin I appeared to involve JAK2/STAT3 signalling pathway inhibition, and the use of JAK2/STAT3 activators effectively restored the inhibition.	cucurbitacin I	76-90	signal transducer and activator of transcription 3	Mus musculus	173-178
35401187-0	2022	Inhibition of STAT3 Signaling Pathway by Terphenyllin Suppresses Growth and Metastasis of Gastric Cancer.	terphenyllin	41-53	signal transducer and activator of transcription 3	Mus musculus	14-19
35401187-4	2022	In this study, we performed a virtual screening by molecular docking and found that terphenyllin, a marine-derived natural product, directly interacted with STAT3.	terphenyllin	84-96	signal transducer and activator of transcription 3	Mus musculus	157-162
35401187-5	2022	We further found that terphenyllin inhibited the phosphorylation and activation of STAT3 and decreased the protein levels of STAT3-dependent target genes, including c-Myc and Cyclin D1.	terphenyllin	22-34	signal transducer and activator of transcription 3	Mus musculus	83-88
35401187-5	2022	We further found that terphenyllin inhibited the phosphorylation and activation of STAT3 and decreased the protein levels of STAT3-dependent target genes, including c-Myc and Cyclin D1.	terphenyllin	22-34	signal transducer and activator of transcription 3	Mus musculus	125-130
35401187-9	2022	Taken together, our results indicated that terphenyllin exerts its anticancer activity by inhibiting the STAT3 signaling pathway and may serve as a potent STAT3 inhibitor for gastric cancer treatment.	terphenyllin	43-55	signal transducer and activator of transcription 3	Mus musculus	105-110
35401187-9	2022	Taken together, our results indicated that terphenyllin exerts its anticancer activity by inhibiting the STAT3 signaling pathway and may serve as a potent STAT3 inhibitor for gastric cancer treatment.	terphenyllin	43-55	signal transducer and activator of transcription 3	Mus musculus	155-160
35331238-6	2022	The experiments showed that ZnO/Ag nanoparticles could exhibit a self-therapeutic effect that was attributed to reducing innate cytokine profiles by inactivating p65 in proinflammatory macrophages and abrogating secretion of adaptive cytokines in KCs by downregulating ROS-mediated STAT3-cyclin D1 signaling.	Zinc Oxide	28-31	signal transducer and activator of transcription 3	Mus musculus	282-287
35228612-5	2022	In the soleus of phentolamine treated animals, we observed the downregulation of phosphorylated signal transducer and activator of transcription factor 3 (p-STAT3) as well as muscle atrophy-related genes Myogenin, muscle ring finger 1 (MuRF-1), and Forkhead box O proteins (FoxO1, FoxO3).	Phentolamine	17-29	signal transducer and activator of transcription 3	Mus musculus	157-162
35131329-6	2022	In vitro, nicotine increased the levels of alpha5-nAChR, p-STAT3, and NLRP3 inflammasome expression, accompanied by the expression of caspase-1, IL-1beta and IL-18.	Nicotine	10-18	signal transducer and activator of transcription 3	Mus musculus	59-64
35131329-7	2022	Nicotine-induced activation of p-STAT3 and NLRP3 inflammasome signaling were inhibited by the silencing of alpha5-nAChR.	Nicotine	0-8	signal transducer and activator of transcription 3	Mus musculus	33-38
35131329-11	2022	Together, these findings reveal a novel nicotine-mediated signaling pathway: nicotine promotes lung cell proliferation and migration via the alpha5-nAChR/STAT3/NLRP3 axis in lung cancer.	Nicotine	40-48	signal transducer and activator of transcription 3	Mus musculus	154-159
35131329-11	2022	Together, these findings reveal a novel nicotine-mediated signaling pathway: nicotine promotes lung cell proliferation and migration via the alpha5-nAChR/STAT3/NLRP3 axis in lung cancer.	Nicotine	77-85	signal transducer and activator of transcription 3	Mus musculus	154-159
35414769-0	2022	Disruption of peroxisome proliferator-activated receptor alpha in hepatocytes protects against acetaminophen-induced liver injury by activating the IL-6/STAT3 pathway.	Acetaminophen	95-108	signal transducer and activator of transcription 3	Mus musculus	153-158
35414769-11	2022	Conclusions: Hepatocyte-specific disruption of the Ppara gene protects against acetaminophen-induced liver injury by reducing oxidative stress and upregulating the hepatoprotective IL-6/STAT3 signaling pathway.	Acetaminophen	79-92	signal transducer and activator of transcription 3	Mus musculus	186-191
35293347-11	2022	Finally, the expression and phosphorylation of STAT3 were down-regulated after a single or dual treatment with BEZ235 and R848.	dactolisib	111-117	signal transducer and activator of transcription 3	Mus musculus	47-52
35293347-11	2022	Finally, the expression and phosphorylation of STAT3 were down-regulated after a single or dual treatment with BEZ235 and R848.	resiquimod	122-126	signal transducer and activator of transcription 3	Mus musculus	47-52
35293347-12	2022	CONCLUSION: Our results conclude that treatment with the combination of BEZ235 and R848 interferes with immune evasion mechanisms through STAT3-signaling pathway in WEHI-3 leukemia cells.	dactolisib	72-78	signal transducer and activator of transcription 3	Mus musculus	138-143
35293347-12	2022	CONCLUSION: Our results conclude that treatment with the combination of BEZ235 and R848 interferes with immune evasion mechanisms through STAT3-signaling pathway in WEHI-3 leukemia cells.	resiquimod	83-87	signal transducer and activator of transcription 3	Mus musculus	138-143
35365983-0	2022	(Cetirizine inhibits activation of JAK2-STAT3 pathway and mast cell activation in lung tissue of asthmatic mice).	Cetirizine	1-11	signal transducer and activator of transcription 3	Mus musculus	40-45
35365983-1	2022	Objective To investigate the effects of cetirizine on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and mast cell activation in asthmatic mice by establishing a mouse model of asthma.	Cetirizine	40-50	signal transducer and activator of transcription 3	Mus musculus	69-119
35365983-1	2022	Objective To investigate the effects of cetirizine on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway and mast cell activation in asthmatic mice by establishing a mouse model of asthma.	Cetirizine	40-50	signal transducer and activator of transcription 3	Mus musculus	126-131
35365983-7	2022	Conclusion Cetirizine inhibits JAK2-STAT3 pathway activation and mast cell activation in lung tissue of asthmatic mice.	Cetirizine	11-21	signal transducer and activator of transcription 3	Mus musculus	36-41
35219910-7	2022	We also analyzed the effect of J-113863 on IL-9, IRF4, IL-22, IFN-gamma, STAT3, AhR, and IL-17A mRNA expression levels.	UCB 35625	31-39	signal transducer and activator of transcription 3	Mus musculus	73-78
35147423-0	2022	P38 MAPK, NF-kappaB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression.	Capecitabine	66-78	signal transducer and activator of transcription 3	Mus musculus	29-34
35147423-9	2022	Finally, the P38 MAPK, NF-kappaB, and JAK-STAT3 signaling pathways, which mediate high levels of expression of IL6 or IL8, were identified as potential pathways underlying CAP-induced HFS.	Capecitabine	172-175	signal transducer and activator of transcription 3	Mus musculus	42-47
35294601-10	2022	Furthermore, SM repressed LPS- and ATP-induced inflammatory responses in BV2 cells by regulating the SOCS1/JAK2/STAT3 signaling pathway, which was similar to the anti-inflammatory effects induced by the miRNA-155-5p sponge.	Samarium	13-15	signal transducer and activator of transcription 3	Mus musculus	112-117
35189519-9	2022	The arsenic-mediated gene expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IFN-gamma), MPO and IL-6/STAT3 and TLR2/MyD88/NF-kappaB pathways was found down-regulated.	Arsenic	4-11	signal transducer and activator of transcription 3	Mus musculus	117-122
35370661-5	2022	Moreover, ALA inhibited tumor growth in vivo, and the inhibition of AKR1C1 and STAT3 activation were also found in the murine xenograft model.	alantolactone	10-13	signal transducer and activator of transcription 3	Mus musculus	79-84
35371022-0	2022	Melatonin Maintains Inner Blood-Retinal Barrier by Regulating Microglia via Inhibition of PI3K/Akt/Stat3/NF-kappaB Signaling Pathways in Experimental Diabetic Retinopathy.	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	99-104
35371022-11	2022	Melatonin deactivated microglia via inhibition of PI3K/Akt/Stat3/NF-kappaB signaling pathways, thus maintaining the integrity of iBRB.	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	59-64
35236823-7	2022	We then demonstrated that STAT3-ALDOA mediates ATP-HIF-1alpha signaling and upregulates the HIF-1 target genes adrenomedullin (ADM) and phosphoinositide-dependent kinase-1 (PDK1).	Adenosine Triphosphate	47-50	signal transducer and activator of transcription 3	Mus musculus	26-31
35236823-11	2022	Furthermore, considering that indirect HIF inhibitors are effective in clinical cancer therapy, we treated tumor-bearing BALB/c mice with STAT3 and PI3K/AKT inhibitors and found that the dual-targeting strategy sensitized breast cancer to cisplatin.	Cisplatin	239-248	signal transducer and activator of transcription 3	Mus musculus	138-143
35191227-15	2022	Further analyses suggested that phosphoserine induced a M2-like phenotype in macrophages, which was related to the activation of phosphoserine receptors including T-cell immunoglobin mucin 4 (TIM4) and the FAK-SRC-STAT3 signaling pathway as well as elevated the expression of the histone demethylase Jumonji domain-containing protein 3 (JMJD3).	Phosphoserine	32-45	signal transducer and activator of transcription 3	Mus musculus	214-219
35074616-13	2022	CONCLUSION: miR-197-3p reduces BTZ resistance in MM by inhibiting acetylation-mediated expression of IL-6 and by inactivating JAK/STAT3 signaling pathway.	mir-197-3p	12-22	signal transducer and activator of transcription 3	Mus musculus	130-135
35074616-13	2022	CONCLUSION: miR-197-3p reduces BTZ resistance in MM by inhibiting acetylation-mediated expression of IL-6 and by inactivating JAK/STAT3 signaling pathway.	Bortezomib	31-34	signal transducer and activator of transcription 3	Mus musculus	130-135
35197174-0	2022	Caprylic Acid Improves Lipid Metabolism, Suppresses the Inflammatory Response and Activates the ABCA1/p-JAK2/p-STAT3 Signaling Pathway in C57BL/6J Mice and RAW264.7 Cells.	octanoic acid	0-13	signal transducer and activator of transcription 3	Mus musculus	111-116
35237153-0	2022	Amentoflavone Ameliorates Carrageenan-Induced Pleurisy and Lung Injury by Inhibiting the NF-kappaB/STAT3 Pathways via Nrf2 Activation.	amentoflavone	0-13	signal transducer and activator of transcription 3	Mus musculus	99-104
35157045-0	2022	Sunitinib inhibits STAT3 phosphorylation in cardiac muscle and prevents cardiomyopathy in the mdx mouse model of Duchenne muscular dystrophy.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	19-24
35157045-11	2022	Our results showed sunitinib treatment reduced STAT3 phosphorylation in the heart muscle of mdx mice, improved cardiac electrical function, increased cardiac output and stroke volume, decreased ventricular hypertrophy, reduced cardiomyocytes membrane damage, fibrotic tissue deposition, and slightly decreased cardiac inflammation.	Sunitinib	19-28	signal transducer and activator of transcription 3	Mus musculus	47-52
35144528-14	2022	CONCLUSIONS: Our results indicate that inhibiting S1PR1 signal could alleviate central sensitization and inhibit microglia activity caused by chronic NTG administration via STAT3 signal pathway, which provide a new clue for the clinical treatment of CM.	Nitroglycerin	150-153	signal transducer and activator of transcription 3	Mus musculus	173-178
35185544-0	2021	Suppressing NK Cells by Astragaloside IV Protects Against Acute Ischemic Stroke in Mice Via Inhibiting STAT3.	astragaloside	24-37	signal transducer and activator of transcription 3	Mus musculus	103-108
34520436-7	2022	Intracellular ALK phosphorylation levels and its downstream signaling mediators, STAT3 and ERK, were suppressed by alectinib in each ALK variant-expressing Ba/F3 cell.	alectinib	115-124	signal transducer and activator of transcription 3	Mus musculus	81-86
35280371-0	2022	Polydatin down-regulates the phosphorylation level of STAT3 and induces pyroptosis in triple-negative breast cancer mice with a high-fat diet.	polydatin	0-9	signal transducer and activator of transcription 3	Mus musculus	54-59
35280371-11	2022	Polydatin inhibited p-JAK2 and p-STAT3 mRNA and protein levels.	polydatin	0-9	signal transducer and activator of transcription 3	Mus musculus	33-38
35062070-6	2022	Mechanistically, BDMC was found to activate the JAK2/STAT3 pathway; whereas AG490 (JAK2/STAT3 pathway inhibitor) inhibited BDMC functioning.	bisdemethoxycurcumin	17-21	signal transducer and activator of transcription 3	Mus musculus	53-58
35062070-6	2022	Mechanistically, BDMC was found to activate the JAK2/STAT3 pathway; whereas AG490 (JAK2/STAT3 pathway inhibitor) inhibited BDMC functioning.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	76-81	signal transducer and activator of transcription 3	Mus musculus	88-93
35062070-6	2022	Mechanistically, BDMC was found to activate the JAK2/STAT3 pathway; whereas AG490 (JAK2/STAT3 pathway inhibitor) inhibited BDMC functioning.	bisdemethoxycurcumin	123-127	signal transducer and activator of transcription 3	Mus musculus	88-93
35061151-0	2022	Diallyl Disulfide Attenuates STAT3 and NF-kappaB Pathway Through PPAR-gamma Activation in Cerulein-Induced Acute Pancreatitis and Associated Lung Injury in Mice.	diallyl disulfide	0-17	signal transducer and activator of transcription 3	Mus musculus	29-34
35061151-5	2022	Our findings revealed that DADS blocked TNF-alpha, CSE expression, H2S production, and STAT3, and NF-kappaB activation was reversed by GW9662.	2-chloro-5-nitrobenzanilide	135-141	signal transducer and activator of transcription 3	Mus musculus	87-92
34380908-8	2022	In addition, treatment with AG490, a selective inhibitor of JAK2/STAT3, weakened the protective effects of KLF7.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-33	signal transducer and activator of transcription 3	Mus musculus	65-70
35115789-16	2022	STAT3 overexpression reversed the suppressive effects of exosomal miR-301a-3p on ASMCs under PDGF-BB stimulation.	-301a	69-74	signal transducer and activator of transcription 3	Mus musculus	0-5
35115789-18	2022	Exosomal miR-301a-3p inhibited OVA-induced lung injury by targeting STAT3 in mice.	mir-301a-3p	9-20	signal transducer and activator of transcription 3	Mus musculus	68-73
35153762-0	2021	P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-kappaB and STAT3 Pathways.	Polysaccharides	17-32	signal transducer and activator of transcription 3	Mus musculus	129-134
35153762-0	2021	P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-kappaB and STAT3 Pathways.	Imiquimod	44-53	signal transducer and activator of transcription 3	Mus musculus	129-134
35153751-0	2021	Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling Pathways.	Flavonoids	8-17	signal transducer and activator of transcription 3	Mus musculus	111-116
35153751-0	2021	Natural Flavonoid Pectolinarigenin Alleviated Hyperuricemic Nephropathy via Suppressing TGFbeta/SMAD3 and JAK2/STAT3 Signaling Pathways.	pectolinarigenin	18-34	signal transducer and activator of transcription 3	Mus musculus	111-116
35023338-0	2022	Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.	Selenium	22-30	signal transducer and activator of transcription 3	Mus musculus	114-119
35023338-0	2022	Mitigation Effects of Selenium Nanoparticles on Depression-Like Behavior Induced by Fluoride in Mice via the JAK2-STAT3 Pathway.	Fluorides	84-92	signal transducer and activator of transcription 3	Mus musculus	114-119
35023338-4	2022	In this study, we applied selenium nanoparticles (SeNPs) for F-induced depression disease mitigation by regulating the histopathology, metabolic index, genes, and protein expression related to the JAK2-STAT3 signaling pathway in vivo.	Selenium	26-34	signal transducer and activator of transcription 3	Mus musculus	202-207
35023338-7	2022	Importantly, 1 mg Se/kg BW/day SeNPs alleviated the microglial ramification index as well as solidity changes and decreased the interleukin-1beta secretion induced by F by suppressing the p-STAT3 nuclear translocation (P < 0.01).	Fluorides	167-168	signal transducer and activator of transcription 3	Mus musculus	190-195
35116094-0	2022	Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway.	liensinine	0-10	signal transducer and activator of transcription 3	Mus musculus	80-85
35116094-0	2022	Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway.	Reactive Oxygen Species	43-46	signal transducer and activator of transcription 3	Mus musculus	80-85
35116094-12	2022	Additionally, liensinine promoted intracellular ROS production, enhanced the GSSG/GSH ratio, and induced MMP loss and ROS-mediated suppression of the JAK2/STAT3 pathway.	liensinine	14-24	signal transducer and activator of transcription 3	Mus musculus	155-160
35116094-12	2022	Additionally, liensinine promoted intracellular ROS production, enhanced the GSSG/GSH ratio, and induced MMP loss and ROS-mediated suppression of the JAK2/STAT3 pathway.	Reactive Oxygen Species	118-121	signal transducer and activator of transcription 3	Mus musculus	155-160
35116094-13	2022	NAC significantly attenuated the liensinine-induced antitumor activities and activated the JAK2/STAT3 pathway.	liensinine	33-43	signal transducer and activator of transcription 3	Mus musculus	96-101
35116094-15	2022	In conclusion, liensinine-induced ROS production could suppress the activation of the JAK2/STAT3 pathway and inhibit the OS growth both in vivo and in vitro.	liensinine	15-25	signal transducer and activator of transcription 3	Mus musculus	91-96
35116094-15	2022	In conclusion, liensinine-induced ROS production could suppress the activation of the JAK2/STAT3 pathway and inhibit the OS growth both in vivo and in vitro.	Reactive Oxygen Species	34-37	signal transducer and activator of transcription 3	Mus musculus	91-96
35140622-8	2022	In the carotid artery ligation animal model, smooth muscle-specific deletion of LGL1 accelerated neointimal hyperplasia, which was attenuated by the STAT3 inhibitor SH-4-54.	SH-4-54	165-172	signal transducer and activator of transcription 3	Mus musculus	149-154
35126352-11	2021	Furthermore, DHA"s effects were associated with downregulation of cSiO2-induced pathways involving i) inhibition of ARE-mediated mRNA decay, ii) bacterial and viral pattern recognition receptor activation, or iii) TREM1, STAT3, NF-kappaB, and VEGF signaling and with upregulation of PPAR, LXR/RXR and PPARalpha/RXRalpha signaling.	Docosahexaenoic Acids	13-16	signal transducer and activator of transcription 3	Mus musculus	221-226
35126352-11	2021	Furthermore, DHA"s effects were associated with downregulation of cSiO2-induced pathways involving i) inhibition of ARE-mediated mRNA decay, ii) bacterial and viral pattern recognition receptor activation, or iii) TREM1, STAT3, NF-kappaB, and VEGF signaling and with upregulation of PPAR, LXR/RXR and PPARalpha/RXRalpha signaling.	csio2	66-71	signal transducer and activator of transcription 3	Mus musculus	221-226
35118141-7	2021	Western blot and immunofluorescence results indicated that STAT3 phosphorylation induced by LPS was inhibited by Bazedoxifene.	bazedoxifene	113-125	signal transducer and activator of transcription 3	Mus musculus	59-64
35096831-10	2021	The presence of specific inhibitors of alphavbeta3/5 integrin, FAK or STAT3 abolished MFG-E8"s effect on cerulein + LPS-induced ER stress in pancreatic acinar cells.	Ceruletide	105-113	signal transducer and activator of transcription 3	Mus musculus	70-75
35172257-13	2022	CFF-1 in combination with docetaxol (DTX) produced a synergistic effects by sensitizing the inhibitory effect of DTX on JAK1/STAT3 pathway targeting PD-L1 blockade.	Docetaxel	26-35	signal transducer and activator of transcription 3	Mus musculus	125-130
35172257-13	2022	CFF-1 in combination with docetaxol (DTX) produced a synergistic effects by sensitizing the inhibitory effect of DTX on JAK1/STAT3 pathway targeting PD-L1 blockade.	Docetaxel	37-40	signal transducer and activator of transcription 3	Mus musculus	125-130
35172257-13	2022	CFF-1 in combination with docetaxol (DTX) produced a synergistic effects by sensitizing the inhibitory effect of DTX on JAK1/STAT3 pathway targeting PD-L1 blockade.	Docetaxel	113-116	signal transducer and activator of transcription 3	Mus musculus	125-130
35053502-5	2022	Specifically, we demonstrate that depletion of STAT3 significantly enhances cell survival after treatment with Pimozide, suggesting that STAT3 confers a particular vulnerability to GBM.	Pimozide	111-119	signal transducer and activator of transcription 3	Mus musculus	47-52
35053502-5	2022	Specifically, we demonstrate that depletion of STAT3 significantly enhances cell survival after treatment with Pimozide, suggesting that STAT3 confers a particular vulnerability to GBM.	Pimozide	111-119	signal transducer and activator of transcription 3	Mus musculus	137-142
35046650-2	2022	This study reports the entrapment of an antimetastatic Signal Transducer and Activator of Transcription 3 (STAT3) dimerization blocker, Stattic (S) into a chitosan-coated-poly(lactic-co-glycolic acid) (C-PLGA) nanocarrier and the improvement on the drug"s physicochemical, in vitro and in vivo antimetastatic properties post entrapment.	(lactic-co-glycolic acid)	175-200	signal transducer and activator of transcription 3	Mus musculus	55-105
35046650-2	2022	This study reports the entrapment of an antimetastatic Signal Transducer and Activator of Transcription 3 (STAT3) dimerization blocker, Stattic (S) into a chitosan-coated-poly(lactic-co-glycolic acid) (C-PLGA) nanocarrier and the improvement on the drug"s physicochemical, in vitro and in vivo antimetastatic properties post entrapment.	(lactic-co-glycolic acid)	175-200	signal transducer and activator of transcription 3	Mus musculus	107-112
35104762-8	2022	RESULTS: DHA synergistically enhanced the anti-tumor activity of oxaliplatin in colon cancer cells by regulating ROS-mediated ER stress, signal transducer and activator of transcription 3 (STAT3), C-Jun-amino-terminal kinase (JNK), and p38 signaling pathways.	artenimol	9-12	signal transducer and activator of transcription 3	Mus musculus	137-187
35104762-8	2022	RESULTS: DHA synergistically enhanced the anti-tumor activity of oxaliplatin in colon cancer cells by regulating ROS-mediated ER stress, signal transducer and activator of transcription 3 (STAT3), C-Jun-amino-terminal kinase (JNK), and p38 signaling pathways.	artenimol	9-12	signal transducer and activator of transcription 3	Mus musculus	189-194
35104762-8	2022	RESULTS: DHA synergistically enhanced the anti-tumor activity of oxaliplatin in colon cancer cells by regulating ROS-mediated ER stress, signal transducer and activator of transcription 3 (STAT3), C-Jun-amino-terminal kinase (JNK), and p38 signaling pathways.	Oxaliplatin	65-76	signal transducer and activator of transcription 3	Mus musculus	137-187
35104762-8	2022	RESULTS: DHA synergistically enhanced the anti-tumor activity of oxaliplatin in colon cancer cells by regulating ROS-mediated ER stress, signal transducer and activator of transcription 3 (STAT3), C-Jun-amino-terminal kinase (JNK), and p38 signaling pathways.	Oxaliplatin	65-76	signal transducer and activator of transcription 3	Mus musculus	189-194
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	ros	90-93	signal transducer and activator of transcription 3	Mus musculus	28-33
35296207-12	2022	In conclusion, an increase of p67phox expression in response to Zn2+ is an intrinsic adaptive response to I/R and leads to cardioprotection against I/R by upregulating ZIP2 via STAT3.	Zinc	64-68	signal transducer and activator of transcription 3	Mus musculus	177-182
35088608-0	2022	Protective effect of baicalin against arsenic trioxide-induced acute hepatic injury in mice through JAK2/STAT3 signaling pathway.	baicalin	21-29	signal transducer and activator of transcription 3	Mus musculus	105-110
35088608-12	2022	In addition, BA treatment promoted the expression of proteins related to the JAK2/STAT3 signaling pathway.	baicalin	13-15	signal transducer and activator of transcription 3	Mus musculus	82-87
34976224-0	2022	Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation.	Fatty Acids	77-87	signal transducer and activator of transcription 3	Mus musculus	14-19
34976224-6	2022	Results: We found that mitochondrial STAT3 induced NF-kappaB nuclear localization and exacerbated LPS-induced sepsis in parallel with a metabolic switch from mainly using glucose to an increased reliance on fatty acid oxidation (FAO).	Glucose	171-178	signal transducer and activator of transcription 3	Mus musculus	37-42
34976224-6	2022	Results: We found that mitochondrial STAT3 induced NF-kappaB nuclear localization and exacerbated LPS-induced sepsis in parallel with a metabolic switch from mainly using glucose to an increased reliance on fatty acid oxidation (FAO).	Fatty Acids	207-217	signal transducer and activator of transcription 3	Mus musculus	37-42
34976224-11	2022	Curcumin alleviated LPS-mediated sepsis by suppressing the activities of mitochondrial STAT3 and NF-kappaB.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	87-92
35024200-3	2022	Objectives: Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogenic STAT3 signaling pathway using diverse tumor cell lines and a xenograft mouse model.	fangchinoline	45-58	signal transducer and activator of transcription 3	Mus musculus	136-141
35024200-3	2022	Objectives: Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogenic STAT3 signaling pathway using diverse tumor cell lines and a xenograft mouse model.	fangchinoline	60-63	signal transducer and activator of transcription 3	Mus musculus	136-141
35024200-10	2022	In addition, FCN also attenuated DNA binding ability of STAT3 and its translocation into the nucleus.	fangchinoline	13-16	signal transducer and activator of transcription 3	Mus musculus	56-61
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	Acetylcysteine	104-120	signal transducer and activator of transcription 3	Mus musculus	28-33
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	Acetylcysteine	122-125	signal transducer and activator of transcription 3	Mus musculus	28-33
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	diphenyleneiodonium	149-168	signal transducer and activator of transcription 3	Mus musculus	28-33
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	diphenyleneiodonium	170-173	signal transducer and activator of transcription 3	Mus musculus	28-33
35296207-9	2022	Both NAC and DPI prevented upregulation of STAT3 phosphorylation and ZIP2 expression induced by overexpression of p67phox, whereas the STAT3 inhibitor stattic abrogated upregulation ZIP2 expression, indicating that the increase of p67phox at reperfusion is an upstream signaling event responsible for ZIP2 upregulation via STAT3.	Acetylcysteine	5-8	signal transducer and activator of transcription 3	Mus musculus	43-48
35296207-9	2022	Both NAC and DPI prevented upregulation of STAT3 phosphorylation and ZIP2 expression induced by overexpression of p67phox, whereas the STAT3 inhibitor stattic abrogated upregulation ZIP2 expression, indicating that the increase of p67phox at reperfusion is an upstream signaling event responsible for ZIP2 upregulation via STAT3.	Acetylcysteine	5-8	signal transducer and activator of transcription 3	Mus musculus	323-328
35296207-9	2022	Both NAC and DPI prevented upregulation of STAT3 phosphorylation and ZIP2 expression induced by overexpression of p67phox, whereas the STAT3 inhibitor stattic abrogated upregulation ZIP2 expression, indicating that the increase of p67phox at reperfusion is an upstream signaling event responsible for ZIP2 upregulation via STAT3.	diphenyleneiodonium	13-16	signal transducer and activator of transcription 3	Mus musculus	43-48
35296207-9	2022	Both NAC and DPI prevented upregulation of STAT3 phosphorylation and ZIP2 expression induced by overexpression of p67phox, whereas the STAT3 inhibitor stattic abrogated upregulation ZIP2 expression, indicating that the increase of p67phox at reperfusion is an upstream signaling event responsible for ZIP2 upregulation via STAT3.	diphenyleneiodonium	13-16	signal transducer and activator of transcription 3	Mus musculus	323-328
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	42-46	signal transducer and activator of transcription 3	Mus musculus	104-109
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	154-158	signal transducer and activator of transcription 3	Mus musculus	104-109
35296207-10	2022	Experiments also showed that chelation of Zn2+ markedly enhanced p67phox and ZIP2 expression as well as STAT3 phosphorylation, whereas supplementation of Zn2+ had the opposite effects, indicating that cardiac Zn2+ loss upon reperfusion triggers p67phox upregulation.	Zinc	209-213	signal transducer and activator of transcription 3	Mus musculus	104-109
33862151-6	2021	Most importantly, our data revealed that cimetidine, an E-selectin inhibitor, was able to block cell adhesion, extravasation, and metastasis formation in ESDN-null mice, underlying a major role of ESDN in E-selectin transcription upregulation, which according to our data may presumably be linked to STAT3.	Cimetidine	41-51	signal transducer and activator of transcription 3	Mus musculus	300-305
35053428-4	2022	We reconciled our discoveries by identifying several conserved Stat3 binding motifs upstream of the miR-21 gene promoter, and showed that the systemic administration of a miR-21-specific antisense oligonucleotide antagomir reduced the established gastric tumor burden in Gp130F/F mice.	Oligonucleotides	197-212	signal transducer and activator of transcription 3	Mus musculus	63-68
33957118-8	2021	Notably, FAK knockout increased cellular sensitivity to the Stat3 inhibitor CPA7, while FAK reintroduction restored resistance to this drug.	cpa7	76-80	signal transducer and activator of transcription 3	Mus musculus	60-65
33757812-11	2021	RESULTS: (1) Network pharmacology analysis shows that QZLX alleviates psoriasis"s epidermal inflammation, and neovascularization may be achieved by inhibiting the IL6/STAT3 signaling pathway.	qzlx	54-58	signal transducer and activator of transcription 3	Mus musculus	167-172
33639371-12	2021	In RNA sequencing, canonical pathway analysis revealed inactivity of various inflammatory signaling pathways, for example, acute phase response signaling and STAT3 pathways, in the liver and intestine in the CLP model after 24-h H2 inhalation.	Deuterium	229-231	signal transducer and activator of transcription 3	Mus musculus	158-163
33946017-0	2021	Electrophilic nitro-fatty acids suppress psoriasiform dermatitis: STAT3 inhibition as a contributory mechanism.	nitro-fatty acids	14-31	signal transducer and activator of transcription 3	Mus musculus	66-71
33946017-8	2021	Importantly, OA-NO2 diminished STAT3 phosphorylation and nuclear translocation via nitroalkylation of STAT3, which inhibited keratinocyte proliferation.	Nitrogen Dioxide	16-19	signal transducer and activator of transcription 3	Mus musculus	31-36
33946017-8	2021	Importantly, OA-NO2 diminished STAT3 phosphorylation and nuclear translocation via nitroalkylation of STAT3, which inhibited keratinocyte proliferation.	Nitrogen Dioxide	16-19	signal transducer and activator of transcription 3	Mus musculus	102-107
33946017-9	2021	Overall, our results affirm the critical role of both NF-kappaB and STAT3 in the incitement of psoriasiform dermatitis and highlight the pharmacologic potential of small molecule nitroalkenes for the treatment of cutaneous inflammatory diseases, such as psoriasis.	nitroalkenes	179-191	signal transducer and activator of transcription 3	Mus musculus	68-73
33757812-13	2021	(3) QZLX inhibits the IL6/STAT3 signaling pathway and reduces the expression of IL-17, IL-23, and TNF-alpha related to inflammation in peripheral blood, as well as the expression of S100A7 in the lesion area.	qzlx	4-8	signal transducer and activator of transcription 3	Mus musculus	26-31
34042519-9	2021	Our mechanism study showed that PD promoted 5-FU-induced ICD by inactivating signal transducer and activator of transcription 3 (STAT3).	Fluorouracil	44-48	signal transducer and activator of transcription 3	Mus musculus	77-127
34004586-0	2021	Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-kappaB and STAT3 inhibitors.	parthenolide	59-71	signal transducer and activator of transcription 3	Mus musculus	118-123
34004586-0	2021	Design, synthesis and in vivo anticancer activity of novel parthenolide and micheliolide derivatives as NF-kappaB and STAT3 inhibitors.	micheliolide	76-88	signal transducer and activator of transcription 3	Mus musculus	118-123
34056872-3	2021	In this study, we found that C188-9, a small molecule inhibitor of STAT3, exhibited an antifibrotic function, both in vitro and in vivo.	C188-9	29-35	signal transducer and activator of transcription 3	Mus musculus	67-72
34056872-5	2021	Moreover, C188-9 treatment alleviated heart injury and cardiac fibrosis in an isoproterenol-induced mouse model by suppressing STAT3 phosphorylation and activation.	C188-9	10-16	signal transducer and activator of transcription 3	Mus musculus	127-132
34056872-5	2021	Moreover, C188-9 treatment alleviated heart injury and cardiac fibrosis in an isoproterenol-induced mouse model by suppressing STAT3 phosphorylation and activation.	Isoproterenol	78-91	signal transducer and activator of transcription 3	Mus musculus	127-132
34044769-0	2021	Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis.	Glycyrrhizic Acid	0-12	signal transducer and activator of transcription 3	Mus musculus	91-96
34044769-6	2021	Further, western blotting (WB) results indicated that glycyrrhizin promoted the expression of SIRT1 and inhibited the expression of STAT3 and phosphorylated STAT3 (p-STAT3).	Glycyrrhizic Acid	54-66	signal transducer and activator of transcription 3	Mus musculus	132-137
34044769-6	2021	Further, western blotting (WB) results indicated that glycyrrhizin promoted the expression of SIRT1 and inhibited the expression of STAT3 and phosphorylated STAT3 (p-STAT3).	Glycyrrhizic Acid	54-66	signal transducer and activator of transcription 3	Mus musculus	157-162
34044769-6	2021	Further, western blotting (WB) results indicated that glycyrrhizin promoted the expression of SIRT1 and inhibited the expression of STAT3 and phosphorylated STAT3 (p-STAT3).	Glycyrrhizic Acid	54-66	signal transducer and activator of transcription 3	Mus musculus	157-162
34044769-8	2021	However, when glycyrrhizin was added at the same time, the proliferation of IL-17A-HaCaT cells increased, and the expression of STAT3, p-STAT3, and a-STAT3 reduced.	Glycyrrhizic Acid	14-26	signal transducer and activator of transcription 3	Mus musculus	128-133
34044769-8	2021	However, when glycyrrhizin was added at the same time, the proliferation of IL-17A-HaCaT cells increased, and the expression of STAT3, p-STAT3, and a-STAT3 reduced.	Glycyrrhizic Acid	14-26	signal transducer and activator of transcription 3	Mus musculus	137-142
34044769-8	2021	However, when glycyrrhizin was added at the same time, the proliferation of IL-17A-HaCaT cells increased, and the expression of STAT3, p-STAT3, and a-STAT3 reduced.	Glycyrrhizic Acid	14-26	signal transducer and activator of transcription 3	Mus musculus	137-142
34044769-10	2021	CONCLUSIONS: Together, these results indicated that glycyrrhizin improved psoriasis by inhibiting the expression of IL-17A and IFN-gamma in vivo and suppressed the proliferation of IL-17A-HaCaT cells and the expression of STAT3, p-STAT3, and a-STAT3 by upregulating SIRT1 in vitro.	Glycyrrhizic Acid	52-64	signal transducer and activator of transcription 3	Mus musculus	222-227
34044769-10	2021	CONCLUSIONS: Together, these results indicated that glycyrrhizin improved psoriasis by inhibiting the expression of IL-17A and IFN-gamma in vivo and suppressed the proliferation of IL-17A-HaCaT cells and the expression of STAT3, p-STAT3, and a-STAT3 by upregulating SIRT1 in vitro.	Glycyrrhizic Acid	52-64	signal transducer and activator of transcription 3	Mus musculus	231-236
34044769-10	2021	CONCLUSIONS: Together, these results indicated that glycyrrhizin improved psoriasis by inhibiting the expression of IL-17A and IFN-gamma in vivo and suppressed the proliferation of IL-17A-HaCaT cells and the expression of STAT3, p-STAT3, and a-STAT3 by upregulating SIRT1 in vitro.	Glycyrrhizic Acid	52-64	signal transducer and activator of transcription 3	Mus musculus	231-236
32113685-3	2021	Here, by performing chemical screening for BMP substitutes, we identified a small molecule, TCS21311, that can replace BMP7 and revealed a novel inhibitory role of BMP7 in JAK3-STAT3 signaling in NPC expansion culture.	tcs21311	92-100	signal transducer and activator of transcription 3	Mus musculus	177-182
34004586-8	2021	Anticancer mechanism studies revealed that 9-oxomicheliolide exhibited inhibition effect against NF-kappaB and STAT3 signaling pathways, as well as induction effects of cell apoptosis.	9-oxomicheliolide	43-60	signal transducer and activator of transcription 3	Mus musculus	111-116
33687738-12	2021	CONCLUSIONS AND IMPLICATIONS: TA exhibits antineoplastic activity by suppressing the STAT3 activation in pancreatic cancer.	trienomycin A	30-32	signal transducer and activator of transcription 3	Mus musculus	85-90
33687738-13	2021	TA could be a novel therapeutic candidate for pancreatic cancer by blocking the STAT3 pathway.	trienomycin A	0-2	signal transducer and activator of transcription 3	Mus musculus	80-85
33636226-5	2021	This phenomenon was also confirmed in Dnmt3l conditional knockin mice, which could be rescued by STAT1 and STAT3 phosphorylation inhibitors (Fludarabine and SH-4-54) but not DNA methylation inhibitor (Decitabine).	fludarabine	141-152	signal transducer and activator of transcription 3	Mus musculus	107-112
34059068-10	2021	Results confirmed BAF312@cRGD-CaP-NP could dramatically inhibit tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the S1PR1/P-STAT3/VEGFA axis.	siponimod	18-24	signal transducer and activator of transcription 3	Mus musculus	171-176
34059068-11	2021	CONCLUSIONS: Our data suggest a potent role for BAF312@cRGD-CaP-NPs in treating BRCA, especially TNBC by downregulating the S1PR1/P-STAT3/VEGFA axis.	siponimod	48-54	signal transducer and activator of transcription 3	Mus musculus	132-137
34050236-6	2021	Berberine also significantly inhibited the phosphorylation of p38 MAPK, ERK1/2, IkB-alpha, and STAT3 in poly I:C-induced RAW 264.7 cells.	Berberine	0-9	signal transducer and activator of transcription 3	Mus musculus	95-100
34050236-7	2021	Additionally, berberine significantly decreased the mRNA expressions of Chop (GADD153), Stat1, Stat3, and Fas in poly I:C-induced RAW 264.7 cells.	Berberine	14-23	signal transducer and activator of transcription 3	Mus musculus	95-100
34042519-9	2021	Our mechanism study showed that PD promoted 5-FU-induced ICD by inactivating signal transducer and activator of transcription 3 (STAT3).	Fluorouracil	44-48	signal transducer and activator of transcription 3	Mus musculus	129-134
34042519-12	2021	Conclusion: This study indicated that PD enhances 5-FU-induced ICD and anti-tumor effect in CRC by inactivating STAT3.	Fluorouracil	50-54	signal transducer and activator of transcription 3	Mus musculus	112-117
34043988-9	2021	The results suggest that Baricitinib significantly reduced phosphorylation of STAT3 and STAT1 levels in turn attenuating the downstream expression of inflammatory cytokines.	baricitinib	25-36	signal transducer and activator of transcription 3	Mus musculus	78-83
34044017-0	2021	YAP/STAT3 promotes the immune escape of larynx carcinoma by activating VEGFR1-TGFbeta signaling to facilitate PD-L1 expression in M2-like TAMs.	Tamoxifen	138-142	signal transducer and activator of transcription 3	Mus musculus	4-9
34044017-10	2021	We revealed that dysregulated YAP/STAT3 activity in LC cells could enhance the secretion of VEGF, which then functioned on M2-like TAMs via activating VEGFR1-TGFbetabeta pathway to promote the expression of PD-L1 and immunosuppressive function of M2-like TAMs.	Tamoxifen	131-135	signal transducer and activator of transcription 3	Mus musculus	34-39
34044017-10	2021	We revealed that dysregulated YAP/STAT3 activity in LC cells could enhance the secretion of VEGF, which then functioned on M2-like TAMs via activating VEGFR1-TGFbetabeta pathway to promote the expression of PD-L1 and immunosuppressive function of M2-like TAMs.	Tamoxifen	255-259	signal transducer and activator of transcription 3	Mus musculus	34-39
33908440-6	2021	Moreover, genistein significantly inhibited the increased expressions of pro-inflammatory factors in skin and peripheral blood, and down-regulated the levels of p-ERK, p-p38 and p-STAT3 in skin and DRGs.	Genistein	10-19	signal transducer and activator of transcription 3	Mus musculus	180-185
34018660-0	2021	Effects of manganese on microglia M1/M2 polarization and SIRT1-mediated transcription of STAT3-dependent genes in mouse.	Manganese	11-20	signal transducer and activator of transcription 3	Mus musculus	89-94
34029668-8	2021	However, Rsv reduced the phosphorylated and acetylated levels of NF-kappaB and STAT3, and attenuated Mn-induced oxidative stress and inflammatory cytokines by activating SIRT1 signaling.	Resveratrol	9-12	signal transducer and activator of transcription 3	Mus musculus	79-84
34008239-0	2021	Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.	rosmarinic acid	0-15	signal transducer and activator of transcription 3	Mus musculus	135-140
34003531-5	2021	Mechanistically, TAM co-culture or additional CCL5 can mediate the STAT3-dependent epithelial-mesenchymal transition (EMT) process, resulting in distant metastasis in prostatic cancer.	tam	17-20	signal transducer and activator of transcription 3	Mus musculus	67-72
34008239-0	2021	Rosmarinic acid protects mice from imiquimod induced psoriasis-like skin lesions by inhibiting the IL-23/Th17 axis via regulating Jak2/Stat3 signaling pathway.	Imiquimod	35-44	signal transducer and activator of transcription 3	Mus musculus	135-140
34008239-7	2021	The findings suggest that RA inhibits psoriasis-like skin inflammation in vivo and in vitro by reducing the expression of IL-23, inhibiting Th17 dominated inflammation and down regulating the Jak2/Stat3 signal pathway.	rosmarinic acid	26-28	signal transducer and activator of transcription 3	Mus musculus	197-202
34010664-0	2021	The antioxidant role of STAT3 in methylmercury-induced toxicity in mouse hypothalamic neuronal GT1-7 cell line.	methylmercury II	33-46	signal transducer and activator of transcription 3	Mus musculus	24-29
34010664-7	2021	Pharmacological inhibition of STAT3 phosphorylation exacerbated MeHg-induced reactive oxygen species (ROS) production and antioxidant responses.	Reactive Oxygen Species	77-100	signal transducer and activator of transcription 3	Mus musculus	30-35
34010664-7	2021	Pharmacological inhibition of STAT3 phosphorylation exacerbated MeHg-induced reactive oxygen species (ROS) production and antioxidant responses.	Reactive Oxygen Species	102-105	signal transducer and activator of transcription 3	Mus musculus	30-35
34010664-8	2021	Finally, treatment with the antioxidant Trolox demonstrated that MeHg-induced STAT3 activation is mediated, at least in part, by MeHg-induced ROS generation.	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	40-46	signal transducer and activator of transcription 3	Mus musculus	78-83
34010664-8	2021	Finally, treatment with the antioxidant Trolox demonstrated that MeHg-induced STAT3 activation is mediated, at least in part, by MeHg-induced ROS generation.	mehg	65-69	signal transducer and activator of transcription 3	Mus musculus	78-83
34010664-8	2021	Finally, treatment with the antioxidant Trolox demonstrated that MeHg-induced STAT3 activation is mediated, at least in part, by MeHg-induced ROS generation.	mehg	129-133	signal transducer and activator of transcription 3	Mus musculus	78-83
34010664-8	2021	Finally, treatment with the antioxidant Trolox demonstrated that MeHg-induced STAT3 activation is mediated, at least in part, by MeHg-induced ROS generation.	Reactive Oxygen Species	142-145	signal transducer and activator of transcription 3	Mus musculus	78-83
34010664-9	2021	Combined, our results demonstrated a role for the STAT3 signaling pathway as an early response to MeHg-induced oxidative stress.	mehg	98-102	signal transducer and activator of transcription 3	Mus musculus	50-55
34017187-0	2021	Anti-Septic Potential of 7-alpha-Obacunyl Acetate Isolated from the Toona sinensis on Cecal Ligation/Puncture Mice via Suppression of JAK-STAT/NF-kappaB Signal Pathway.	CHEBI:69046	25-49	signal transducer and activator of transcription 3	Mus musculus	138-142
33990689-0	2021	2"-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice.	2"-hydroxycinnamaldehyde	0-24	signal transducer and activator of transcription 3	Mus musculus	99-104
33990689-0	2021	2"-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice.	Imiquimod	37-46	signal transducer and activator of transcription 3	Mus musculus	99-104
34017187-5	2021	Effects of 7-OBA on NF-kappaB and JAK2-STAT3 signaling pathways were determined by Western blot analysis in a lipopolysaccharide (LPS) stimulated RAW264.7 cells model.	7-oba	11-16	signal transducer and activator of transcription 3	Mus musculus	39-44
34017187-9	2021	The anti-sepsis effect of 7-OBA might be associated with regulation of nuclear factor kappa-B (NF-kappaB) and Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signal pathways.	7-oba	26-31	signal transducer and activator of transcription 3	Mus musculus	132-182
34017187-9	2021	The anti-sepsis effect of 7-OBA might be associated with regulation of nuclear factor kappa-B (NF-kappaB) and Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) signal pathways.	7-oba	26-31	signal transducer and activator of transcription 3	Mus musculus	184-189
34054543-3	2021	Glutamine metabolites can activate EGFR downstream signals, including mTOR, ERK1/2, STAT3, etc., which is an important cause for the decreased sensitivity of NSCLC to EGFR-TKIs.	Glutamine	0-9	signal transducer and activator of transcription 3	Mus musculus	84-89
33992630-7	2021	Cynandione A significantly stimulated STAT3 phosphorylation, which was attenuated by methyllycaconitine and the IL-10 neutralizing antibody.	cynandione A	0-12	signal transducer and activator of transcription 3	Mus musculus	38-43
33992630-7	2021	Cynandione A significantly stimulated STAT3 phosphorylation, which was attenuated by methyllycaconitine and the IL-10 neutralizing antibody.	methyllycaconitine	85-103	signal transducer and activator of transcription 3	Mus musculus	38-43
33992630-8	2021	The STAT3 activation inhibitor NSC74859 also blocked cynandione A-inhibited proinflammatory cytokine expression.	NSC 74859	31-39	signal transducer and activator of transcription 3	Mus musculus	4-9
33992630-8	2021	The STAT3 activation inhibitor NSC74859 also blocked cynandione A-inhibited proinflammatory cytokine expression.	cynandione A	53-65	signal transducer and activator of transcription 3	Mus musculus	4-9
33980886-7	2021	The mechanism by which butamirate and oxelaidin inhibits GBM cell growth involves the suppression of STAT3 transcriptional activity, leading to down-regulation of cyclin D1 and survivin.	butamirate	23-33	signal transducer and activator of transcription 3	Mus musculus	101-106
34052328-5	2021	Luteolin and apigenin significantly inhibited lung cancer cell growth, induced cell apoptosis, and down-regulated the IFN-gamma-induced PD-L1 expression by suppressing the phosphorylation of STAT3.	Luteolin	0-8	signal transducer and activator of transcription 3	Mus musculus	191-196
34052328-5	2021	Luteolin and apigenin significantly inhibited lung cancer cell growth, induced cell apoptosis, and down-regulated the IFN-gamma-induced PD-L1 expression by suppressing the phosphorylation of STAT3.	Apigenin	13-21	signal transducer and activator of transcription 3	Mus musculus	191-196
33980886-7	2021	The mechanism by which butamirate and oxelaidin inhibits GBM cell growth involves the suppression of STAT3 transcriptional activity, leading to down-regulation of cyclin D1 and survivin.	Oxeladin	38-47	signal transducer and activator of transcription 3	Mus musculus	101-106
33980886-8	2021	In addition, components of RRAD-associated signaling cascades, including p-EGFR, p-Akt, and p-STAT3, were inhibited upon oxelaidin treatment.	Oxeladin	121-130	signal transducer and activator of transcription 3	Mus musculus	94-99
33994809-13	2021	SB431542 strongly suppressed migration, invasion as well as the expressions of EMT relevant proteins and p-STAT3 (Ser727) of co-cultured RM-1.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	0-8	signal transducer and activator of transcription 3	Mus musculus	107-112
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	Curcumin	2-10	signal transducer and activator of transcription 3	Mus musculus	111-116
33982329-0	2021	A curcumin analogue GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circZNF83/miR-324-5p/CDK16 axis.	gl63	20-24	signal transducer and activator of transcription 3	Mus musculus	111-116
33982329-16	2021	In addition, GL63 inactivated the JAK2/STAT3 pathway via downregulating circZNF83 to mediate the miR-324-5p/CDK16 axis.	gl63	13-17	signal transducer and activator of transcription 3	Mus musculus	39-44
33982329-17	2021	GL63 also repressed tumor growth in vivo through the circZNF83/miR-324-5p/CDK16-mediated JAK2/STAT3 signal inhibition.	gl63	0-4	signal transducer and activator of transcription 3	Mus musculus	94-99
33982329-18	2021	CONCLUSION: This study suggested GL63 impeded the HCC development by blocking the JAK2/STAT3 signaling pathway via mediating the circZNF83/miR-324-5p/CDK16 axis.	gl63	33-37	signal transducer and activator of transcription 3	Mus musculus	87-92
33992648-0	2021	A targetable, non-canonical STAT3 activation induced by the tyrosine-less region of IL-22R orchestrates imiquimod-induced psoriasis-like dermatitis in mice.	Tyrosine	60-68	signal transducer and activator of transcription 3	Mus musculus	28-33
33992648-0	2021	A targetable, non-canonical STAT3 activation induced by the tyrosine-less region of IL-22R orchestrates imiquimod-induced psoriasis-like dermatitis in mice.	Imiquimod	104-113	signal transducer and activator of transcription 3	Mus musculus	28-33
33992648-4	2021	The second depends on the C-terminal tyrosine-less region of IL-22Ra and leads to massive STAT3 activation.	Tyrosine	37-45	signal transducer and activator of transcription 3	Mus musculus	90-95
33992648-5	2021	As STAT3 activation is associated with the development of psoriasis, we hypothesized that the specific inhibition of the non-canonical STAT3 activation by the tyrosine-less region of IL-22Ra could reduce psoriasis-like disease while leaving intact its tissue defense functions in the gut.	Tyrosine	159-167	signal transducer and activator of transcription 3	Mus musculus	3-8
33992648-5	2021	As STAT3 activation is associated with the development of psoriasis, we hypothesized that the specific inhibition of the non-canonical STAT3 activation by the tyrosine-less region of IL-22Ra could reduce psoriasis-like disease while leaving intact its tissue defense functions in the gut.	Tyrosine	159-167	signal transducer and activator of transcription 3	Mus musculus	135-140
33975030-14	2021	LPA induced the translocation of Stat3 to the cell membrane and promoted the interaction between Rac1 and Stat3.	lysophosphatidic acid	0-3	signal transducer and activator of transcription 3	Mus musculus	33-38
33975030-14	2021	LPA induced the translocation of Stat3 to the cell membrane and promoted the interaction between Rac1 and Stat3.	lysophosphatidic acid	0-3	signal transducer and activator of transcription 3	Mus musculus	106-111
33975030-15	2021	Inhibition of Stat3 ablated LPA-mediated regulation of claudin-4.	lysophosphatidic acid	28-31	signal transducer and activator of transcription 3	Mus musculus	14-19
32424774-0	2021	Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-kB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice.	tetramethylpyrazine	0-19	signal transducer and activator of transcription 3	Mus musculus	124-129
33947424-0	2021	Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	78-83
33947424-10	2021	To investigate how metformin modulates the inflammatory process in skin fibroblasts, we measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.	Metformin	19-28	signal transducer and activator of transcription 3	Mus musculus	102-107
33947424-10	2021	To investigate how metformin modulates the inflammatory process in skin fibroblasts, we measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.	Metformin	19-28	signal transducer and activator of transcription 3	Mus musculus	192-197
33947424-11	2021	These results suggest that metformin has potential to treat scleroderma by inhibiting pro-inflammatory cytokines and anti-inflammatory activity mediated by mTOR-STAT3 signaling.	Metformin	27-36	signal transducer and activator of transcription 3	Mus musculus	161-166
32868906-9	2021	In nude mice bearing breast cancer cell line MDA-MB-231 xenografts, treatment with DCV (30 mg kg-1 d-1, ip, for 14 days) markedly suppressed the tumor growth via inhibition of STAT3 activation without observed toxicity.	curvularin	83-86	signal transducer and activator of transcription 3	Mus musculus	176-181
32868906-10	2021	Our results demonstrate that DCV acts as a selective STAT3 inhibitor for breast cancer intervention.	curvularin	29-32	signal transducer and activator of transcription 3	Mus musculus	53-58
32424774-9	2021	In this study, most importantly, we found that TMP protects the BSCB integrity by modulating microglia polarization from M1 phenotype to M2 phenotype through activation of STAT3/SOCS3 and inhibition of NF-kB signaling pathways.	tetramethylpyrazine	47-50	signal transducer and activator of transcription 3	Mus musculus	172-177
33411315-7	2021	Immunostaining indicated that the expression of phosphorylated STAT3 was significantly decreased while the expression of activated caspase 3 was significantly increased in Lmo4 deficient hair cells, post-cisplatin treatment.	Cisplatin	204-213	signal transducer and activator of transcription 3	Mus musculus	63-68
33411315-8	2021	These findings suggest an otoprotective role of LMO4 as cisplatin-induced decrease in cochlear LMO4 could compromise the LMO4/STAT3 cellular defense mechanism to induce ototoxicity.	Cisplatin	56-65	signal transducer and activator of transcription 3	Mus musculus	126-131
33929970-0	2021	Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFbeta1-smad/p38MAPK-lnc865/lnc556-miR-29b-2-5p-STAT3 signal pathway.	acetyl oxygen benzoate	0-22	signal transducer and activator of transcription 3	Mus musculus	178-183
33929970-0	2021	Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFbeta1-smad/p38MAPK-lnc865/lnc556-miR-29b-2-5p-STAT3 signal pathway.	Esters	33-38	signal transducer and activator of transcription 3	Mus musculus	178-183
33929970-7	2021	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b-2-5p to target signal transducer and activator of transcription 3 (STAT3).	aobee	34-39	signal transducer and activator of transcription 3	Mus musculus	180-230
33929970-7	2021	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b-2-5p to target signal transducer and activator of transcription 3 (STAT3).	aobee	34-39	signal transducer and activator of transcription 3	Mus musculus	232-237
33929970-7	2021	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b-2-5p to target signal transducer and activator of transcription 3 (STAT3).	lnc556	90-96	signal transducer and activator of transcription 3	Mus musculus	180-230
33929970-7	2021	Mechanistic study elucidated that AOBEE alleviated pulmonary fibrosis through lnc865- and lnc556-mediated mechanism, in which both lnc865 and lnc556 sponged miR-29b-2-5p to target signal transducer and activator of transcription 3 (STAT3).	lnc556	90-96	signal transducer and activator of transcription 3	Mus musculus	232-237
33640443-8	2021	PHMG-P exposure modulated the expression of genes related to Th17 signaling pathways including the IL-17A, IL-23, and STAT3 signaling pathways, but not the Th2 signaling pathway.	polyhexamethyleneguanidine	0-6	signal transducer and activator of transcription 3	Mus musculus	118-123
34025420-0	2021	Falcarindiol Enhances Cisplatin Chemosensitivity of Hepatocellular Carcinoma via Down-Regulating the STAT3-Modulated PTTG1 Pathway.	falcarindiol	0-12	signal transducer and activator of transcription 3	Mus musculus	101-106
34025420-11	2021	Besides, FAD dampened the STAT3/PTTG1 pathway expression.	falcarindiol	9-12	signal transducer and activator of transcription 3	Mus musculus	26-31
34025420-13	2021	Overall, our study illustrated that FAD is a potential anticancer drug and strengthens the chemosensitivity of HCC cells to DDP by inhibiting the STAT3/PTTG1 pathway.	falcarindiol	36-39	signal transducer and activator of transcription 3	Mus musculus	146-151
33388430-0	2021	Qingxue jiedu Formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-kappaB signaling pathways.	Dinitrofluorobenzene	38-42	signal transducer and activator of transcription 3	Mus musculus	83-88
33910400-8	2021	Moreover, AZD0530 blocked the Src signaling pathway by downregulating phospho-Src and its downstream mediators (p-Stat3, p-Akt, p-FAK, p-p44/42 MAPK, p-p38 MAPK) in post-ischemic brains.	saracatinib	10-17	signal transducer and activator of transcription 3	Mus musculus	114-119
33905080-2	2021	In this study, we identified the bioactive compounds ergosterol peroxide (EPO) and ergosterol (ERG) from the MeOH extract of O. gracilioides mycelia related to its anti-cancer effects by targeting the Nuclear Factor kappa B (NF-kB)/Signal Transducer and Activator of Transcription 3 (STAT3) inflammatory pathways.	ergosterol-5,8-peroxide	53-72	signal transducer and activator of transcription 3	Mus musculus	284-289
33905080-2	2021	In this study, we identified the bioactive compounds ergosterol peroxide (EPO) and ergosterol (ERG) from the MeOH extract of O. gracilioides mycelia related to its anti-cancer effects by targeting the Nuclear Factor kappa B (NF-kB)/Signal Transducer and Activator of Transcription 3 (STAT3) inflammatory pathways.	Ergosterol	53-63	signal transducer and activator of transcription 3	Mus musculus	284-289
33905080-2	2021	In this study, we identified the bioactive compounds ergosterol peroxide (EPO) and ergosterol (ERG) from the MeOH extract of O. gracilioides mycelia related to its anti-cancer effects by targeting the Nuclear Factor kappa B (NF-kB)/Signal Transducer and Activator of Transcription 3 (STAT3) inflammatory pathways.	Ergosterol	95-98	signal transducer and activator of transcription 3	Mus musculus	284-289
33915494-9	2021	Juglone treatment also inhibited the protein expressions of IL-6, STAT3 and RORgammat, meanwhile improved the protein level of FOXP3.	juglone	0-7	signal transducer and activator of transcription 3	Mus musculus	66-71
33900518-16	2021	In addition, miR-93 overexpression inhibited MPTP-induced STAT3 expression, microglial activation and inflammatory reaction and reduced the loss of tyrosine hydroxylase in the substantia nigra of mice.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	45-49	signal transducer and activator of transcription 3	Mus musculus	58-63
33713857-0	2021	Mesencephalic astrocyte-derived neurotrophic factor alleviates alcohol induced hepatic steatosis via activating Stat3-mediated autophagy.	Alcohols	63-70	signal transducer and activator of transcription 3	Mus musculus	112-117
33883215-7	2021	In conclusion, STAT3 but not ERK2 signaling in SF1 neurons of VMH plays a crucial role to protect against DIO in a sex-specific pattern.	3,3'-Dioctadecyloxacarbocyanine perchlorate	106-109	signal transducer and activator of transcription 3	Mus musculus	15-20
33959000-7	2021	SYD also significantly reduced the DSS-induced activation of STAT3 and NF-kappaB signaling.	Dextran Sulfate	35-38	signal transducer and activator of transcription 3	Mus musculus	61-66
33959611-4	2021	Mechanistically, Lpz induced apoptosis and G0/G1 cell cycle arrest by inhibiting the activation of signal transducer and activator of transcription (Stat) 3 and the phosphoinositide 3-kinase (PI3K)/Akt and Raf/ERK pathways.	Lansoprazole	17-20	signal transducer and activator of transcription 3	Mus musculus	99-156
33874954-14	2021	There was a significant increase in the phosphorylation of STAT3, CREB, and Akt1 with 4R treatment in the WT mouse hippocampus following LPS exposure.	4r	86-88	signal transducer and activator of transcription 3	Mus musculus	59-64
33872705-0	2021	Anxiety-like behavior in female mice is modulated by STAT3 signaling in midbrain dopamine neurons.	Dopamine	81-89	signal transducer and activator of transcription 3	Mus musculus	53-58
33872705-2	2021	STAT3 activation plays a pivotal role in the behavioral responses to the adiposity hormone leptin, including in midbrain dopamine (DA) neurons where it mediates the influence of leptin to diminish physical activity and running reward in male mice.	Dopamine	121-129	signal transducer and activator of transcription 3	Mus musculus	0-5
33872705-2	2021	STAT3 activation plays a pivotal role in the behavioral responses to the adiposity hormone leptin, including in midbrain dopamine (DA) neurons where it mediates the influence of leptin to diminish physical activity and running reward in male mice.	Dopamine	131-133	signal transducer and activator of transcription 3	Mus musculus	0-5
33872705-4	2021	To assess the contribution of STAT3 signaling in mesolimbic DA neurons on feeding, mesolimbic DA tone and anxiodepressive behaviors in female mice, we generated dopamine DA-specific STAT3 knockout mice by crossing mice expressing Cre under the control of the dopamine transporter with STAT3-LoxP mice.	Dopamine	161-169	signal transducer and activator of transcription 3	Mus musculus	182-187
33872705-4	2021	To assess the contribution of STAT3 signaling in mesolimbic DA neurons on feeding, mesolimbic DA tone and anxiodepressive behaviors in female mice, we generated dopamine DA-specific STAT3 knockout mice by crossing mice expressing Cre under the control of the dopamine transporter with STAT3-LoxP mice.	Dopamine	161-169	signal transducer and activator of transcription 3	Mus musculus	182-187
33872705-8	2021	In addition to alluding to sex differences in the signalling mechanisms mediating anxiety-like behavior, our findings suggest that activation of STAT3 in midbrain dopamine neurons projecting to the CeA dampens anxiety in a D1R-dependent manner in female mice.	Dopamine	163-171	signal transducer and activator of transcription 3	Mus musculus	145-150
33920736-0	2021	Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells.	pulvomycin	22-32	signal transducer and activator of transcription 3	Mus musculus	57-62
33920736-0	2021	Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells.	Docetaxel	76-85	signal transducer and activator of transcription 3	Mus musculus	57-62
33920736-4	2021	In this study, a docetaxel-resistant TNBC cell line (MDA-MB-231-DTR) was established, and mechanisms for the antitumor activity of pulvomycin, a novel STAT3 inhibitor isolated from marine-derived actinomycete, were investigated.	Docetaxel	17-26	signal transducer and activator of transcription 3	Mus musculus	151-156
33920736-4	2021	In this study, a docetaxel-resistant TNBC cell line (MDA-MB-231-DTR) was established, and mechanisms for the antitumor activity of pulvomycin, a novel STAT3 inhibitor isolated from marine-derived actinomycete, were investigated.	pulvomycin	131-141	signal transducer and activator of transcription 3	Mus musculus	151-156
33920736-5	2021	Levels of activated STAT3 (p-STAT3 (Y705)) increased in docetaxel-resistant cells, and knockdown of STAT3 recovered the sensitivity to docetaxel in MDA-MB-231-DTR cells.	Docetaxel	56-65	signal transducer and activator of transcription 3	Mus musculus	20-25
33920736-5	2021	Levels of activated STAT3 (p-STAT3 (Y705)) increased in docetaxel-resistant cells, and knockdown of STAT3 recovered the sensitivity to docetaxel in MDA-MB-231-DTR cells.	Docetaxel	56-65	signal transducer and activator of transcription 3	Mus musculus	29-34
33920736-5	2021	Levels of activated STAT3 (p-STAT3 (Y705)) increased in docetaxel-resistant cells, and knockdown of STAT3 recovered the sensitivity to docetaxel in MDA-MB-231-DTR cells.	Docetaxel	56-65	signal transducer and activator of transcription 3	Mus musculus	29-34
33920736-5	2021	Levels of activated STAT3 (p-STAT3 (Y705)) increased in docetaxel-resistant cells, and knockdown of STAT3 recovered the sensitivity to docetaxel in MDA-MB-231-DTR cells.	Docetaxel	135-144	signal transducer and activator of transcription 3	Mus musculus	20-25
33920736-7	2021	In addition, pulvomycin suppressed the activation of STAT3 and subsequently induced G0/G1 cell cycle arrest and apoptosis.	pulvomycin	13-23	signal transducer and activator of transcription 3	Mus musculus	53-58
33920736-9	2021	In an MDA-MB-231-DTR-bearing xenograft mouse model, the combination of pulvomycin and docetaxel effectively inhibited tumor growth through STAT3 regulation.	pulvomycin	71-81	signal transducer and activator of transcription 3	Mus musculus	139-144
33920736-9	2021	In an MDA-MB-231-DTR-bearing xenograft mouse model, the combination of pulvomycin and docetaxel effectively inhibited tumor growth through STAT3 regulation.	Docetaxel	86-95	signal transducer and activator of transcription 3	Mus musculus	139-144
33920736-10	2021	Thus, our findings demonstrate that the combination of docetaxel and STAT3 inhibitors is an effective strategy for overcoming docetaxel resistance in TNBC.	Docetaxel	126-135	signal transducer and activator of transcription 3	Mus musculus	69-74
33610598-8	2021	Heparin-iron was also found to cause a reduction on hepcidin expression through BMP/SMAD and JAK/STAT3 pathways in LPS induced acute inflammation model in mice.	Heparin	0-7	signal transducer and activator of transcription 3	Mus musculus	97-102
33485977-0	2021	Bufothionine Induces Autophagy in H22 Hepatoma-bearing Mice by Inhibiting JAK2/STAT3 Pathway, a Possible Anti-cancer Mechanism of Cinobufacini.	bufothionine	0-12	signal transducer and activator of transcription 3	Mus musculus	79-84
33967793-4	2021	The in vitro results showed that Statmp-151 inhibited the proliferation of breast cancer cell lines in a dose- and time-dependent manner and suppressed the phosphorylation of Stat3 in a dose-dependent manner.	statmp-151	33-43	signal transducer and activator of transcription 3	Mus musculus	175-180
33462828-6	2021	STAT3 was phosphorylated in the hearts of AAC-treated mice but this was unrelated to IL11 activity, which we confirmed in mouse cardiac fibroblasts in vitro.	aac	42-45	signal transducer and activator of transcription 3	Mus musculus	0-5
33683737-0	2021	Transplanted hepatocytes rescue mice in acetaminophen-induced acute liver failure through paracrine signals for hepatic ATM and STAT3 pathways.	Acetaminophen	40-53	signal transducer and activator of transcription 3	Mus musculus	128-133
33131062-8	2021	Increased total ceramides was associated with STAT3 activation with downstream activation of multiple immune-inflammatory pathways at a transcriptomic level by network analyses.	Ceramides	16-25	signal transducer and activator of transcription 3	Mus musculus	46-51
33122822-0	2021	The bioflavonoid troxerutin prevents gestational hypertension in mice by inhibiting STAT3 signaling.	Flavonoids	4-16	signal transducer and activator of transcription 3	Mus musculus	84-89
33122822-0	2021	The bioflavonoid troxerutin prevents gestational hypertension in mice by inhibiting STAT3 signaling.	troxerutin	17-27	signal transducer and activator of transcription 3	Mus musculus	84-89
33122822-10	2021	Troxerutin treatment significantly suppressed STAT3/RNF6 signaling.	troxerutin	0-10	signal transducer and activator of transcription 3	Mus musculus	46-51
34007853-9	2021	Three classical inflammatory pathways: MAPKs, IL-6/STAT3, and PI3K were downregulated by UA treatment.	ursolic acid	89-91	signal transducer and activator of transcription 3	Mus musculus	51-56
34017373-11	2021	Furthermore, bilobalide treatment increased the lincRNA-p21 levels, which suppressed STAT3 signalling.	bilobalide	13-23	signal transducer and activator of transcription 3	Mus musculus	85-90
33593544-4	2021	Western blot of joint tissues showed that cDHPS significantly inhibited the phosphorylation of IkappaB, p65, JNK, p38, ERK1/2, AKT, PI3K, JAK1 and STAT3 in CIA mice.	gimeracil	42-47	signal transducer and activator of transcription 3	Mus musculus	147-152
33924467-10	2021	In addition, kurarinone reduced STAT1 and STAT3 phosphorylation and the proportions of Th1 and Th17 cells in lymph nodes.	kurarinone	13-23	signal transducer and activator of transcription 3	Mus musculus	42-47
33722611-0	2021	Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling.	polymer-ritonavir	0-17	signal transducer and activator of transcription 3	Mus musculus	147-152
33897686-9	2021	Results: STAT3 was highly expressed and phosphorylated in cardiac tissue of LCWE-injected mice, and reduced following anakinra treatment.	lcwe	76-80	signal transducer and activator of transcription 3	Mus musculus	9-14
33833412-5	2022	The suppression of KIT phosphorylation and its downstream signals, including AKT/mTOR, STAT3, and ERK1/2, was elicited by cabozantinib treatment and associated with subsequent alterations of cell cycle- and apoptosis-related molecules.	cabozantinib	122-134	signal transducer and activator of transcription 3	Mus musculus	87-92
33834359-6	2021	Moreover, we confirm of therapeutic effects of GB1107, a cell-penetrating galectin-3 specific inhibitor, using orthotopic gastric cancer-bearing mice RESULTS: Increased levels of galectin-3 and STAT3 phosphorylation were detected in the stomach tissues of WNT1-overexpressing mouse models.	GB1107	47-53	signal transducer and activator of transcription 3	Mus musculus	194-199
33834359-10	2021	GB1107, a specific membrane-penetrating inhibitor of galectin-3, significantly reduced the activation of both STAT3 and beta-catenin and inhibited tumor growth in orthotopic gastric cancer-bearing mice.	GB1107	0-6	signal transducer and activator of transcription 3	Mus musculus	110-115
33967779-9	2021	PF treatment also reduced the DSS-induced inflammation by suppressing oxidative stress, NF-kappaB, STAT3, and inflammasome activation, by upregulating nuclear factor erythroid 2-related factor 2 (Nrf-2) and its downstream proteins via extracellular signal-regulated kinase (ERK) phosphorylation.	dss	30-33	signal transducer and activator of transcription 3	Mus musculus	99-104
33951698-5	2021	The results showed that the acute rejection rating of the heart decreased, and the expression of related factors decreased significantly after using the inhibitor AG490, suggesting that the JAK2/STAT3 signaling pathway regulates expression of the Th17/IL-17 axis in cardiac allograft rejection.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	163-168	signal transducer and activator of transcription 3	Mus musculus	195-200
33788814-4	2021	HGF greatly increased the level of phosphorylated STAT3 at serine 727 [pSTAT3 (Ser 727)], thereby translocating the protein to the mitochondria.	Serine	59-65	signal transducer and activator of transcription 3	Mus musculus	50-55
33788814-4	2021	HGF greatly increased the level of phosphorylated STAT3 at serine 727 [pSTAT3 (Ser 727)], thereby translocating the protein to the mitochondria.	Serine	79-82	signal transducer and activator of transcription 3	Mus musculus	50-55
33610598-8	2021	Heparin-iron was also found to cause a reduction on hepcidin expression through BMP/SMAD and JAK/STAT3 pathways in LPS induced acute inflammation model in mice.	Iron	8-12	signal transducer and activator of transcription 3	Mus musculus	97-102
33707115-0	2021	Shikonin-mediated PD-L1 degradation suppresses immune evasion in pancreatic cancer by inhibiting NF-kappaB/STAT3 and NF-kappaB/CSN5 signaling pathways.	shikonin	0-8	signal transducer and activator of transcription 3	Mus musculus	107-112
33710777-12	2021	Moreover, AG490, a selective inhibitor of JAK2/STAT3, eliminated the protective roles of EIP-22.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	10-15	signal transducer and activator of transcription 3	Mus musculus	47-52
33707115-10	2021	Shikonin blocked immune evasion in PC, and lowered the expression of PD-L1, NF-kappaB, NF-kappaB p65, STAT3 and CSN5 in vivo and in vitro.	shikonin	0-8	signal transducer and activator of transcription 3	Mus musculus	102-107
33707115-11	2021	CONCLUSION: The findings indicated Shikonin inhibited immune evasion in PC by inhibiting PD-L1 glycosylation and activating the NF-kappaB/STAT3 and NF-kappaB/CSN5 signaling pathways.	shikonin	35-43	signal transducer and activator of transcription 3	Mus musculus	138-143
33640781-0	2021	Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling.	Dextran Sulfate	33-36	signal transducer and activator of transcription 3	Mus musculus	139-144
33640781-14	2021	CONCLUSIONS: Taken together, these results indicated that GQ alleviated DSS-induced UC by suppressing IL-6/JAK2/STAT3 signaling to restore Treg and Th17 cell homeostasis in colonic tissue.	glycylglutamine	58-60	signal transducer and activator of transcription 3	Mus musculus	112-117
33640781-14	2021	CONCLUSIONS: Taken together, these results indicated that GQ alleviated DSS-induced UC by suppressing IL-6/JAK2/STAT3 signaling to restore Treg and Th17 cell homeostasis in colonic tissue.	Dextran Sulfate	72-75	signal transducer and activator of transcription 3	Mus musculus	112-117
33619515-7	2021	Furthermore, co-treatment of the cardiomyocytes with the STAT3 inhibitor AG490 abrogates the IL-35-induced cardioprotective effects.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	73-78	signal transducer and activator of transcription 3	Mus musculus	57-62
33069729-0	2021	Targeting the JAK/STAT3 pathway with Ruxolitinib in a mouse model of recessive dystrophic epidermolysis bullosa-squamous cell carcinoma.	ruxolitinib	37-48	signal transducer and activator of transcription 3	Mus musculus	18-23
33307054-18	2021	Over-activation of STAT3 in A375 cells significantly attenuated the cytotoxic effects of HHSE.	hhse	89-93	signal transducer and activator of transcription 3	Mus musculus	19-24
33754353-6	2021	Using a streptozotocin-induced type 1 DM model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased STAT3 activation.	Streptozocin	8-22	signal transducer and activator of transcription 3	Mus musculus	133-138
33754353-9	2021	We also demonstrated that STAT3 activation in microglia increased tumor necrosis factor-alpha (TNF-alpha) expression; subsequently, TNF-alpha increased neuronal apoptosis by increasing reactive oxygen species (ROS) levels in the neuronal cells.	Reactive Oxygen Species	185-208	signal transducer and activator of transcription 3	Mus musculus	26-31
33754353-9	2021	We also demonstrated that STAT3 activation in microglia increased tumor necrosis factor-alpha (TNF-alpha) expression; subsequently, TNF-alpha increased neuronal apoptosis by increasing reactive oxygen species (ROS) levels in the neuronal cells.	Reactive Oxygen Species	210-213	signal transducer and activator of transcription 3	Mus musculus	26-31
33758275-9	2021	Our results strongly suggest that the logical strategy in combination with the novel STAT3 inhibitor YHO-1701 and other mechanistically different targeted agents, could be a promising approach in future clinical settings.	yho-1701	101-109	signal transducer and activator of transcription 3	Mus musculus	85-90
33994251-0	2021	Natural flavonol fisetin attenuated hyperuricemic nephropathy via inhibiting IL-6/JAK2/STAT3 and TGF-beta/SMAD3 signaling.	3-hydroxyflavone	8-16	signal transducer and activator of transcription 3	Mus musculus	87-92
33720008-8	2021	Mechanistically, activation of the Wnt pathway following lipid lowering potentiates IL-4 responsiveness in macrophages via a PGE2/STAT3 axis.	Dinoprostone	125-129	signal transducer and activator of transcription 3	Mus musculus	130-135
33682559-0	2021	BP-1-102, a STAT3 inhibitor, reduces intracranial aneurysm rupture and suppresses inflammatory responses in a mouse model.	BP-1-102	0-8	signal transducer and activator of transcription 3	Mus musculus	12-17
33682559-2	2021	This study attempts to reveal the role of BP-1-102, an oral bioavailable STAT3 inhibitor, in IA.	BP-1-102	42-50	signal transducer and activator of transcription 3	Mus musculus	73-78
33682559-7	2021	Furthermore, we found that BP-1-102 inhibited the expression of critical proteins in the nuclear factor kappa-B and Janus kinase 2/STAT3 signaling pathways.	BP-1-102	27-35	signal transducer and activator of transcription 3	Mus musculus	131-136
33727847-10	2021	Results: Our study showed that LCWE increased KCa3.1 protein level in RAW264.7 macrophages and KCa3.1 inhibition by TRAM-34 notably suppressed the expression of pro-inflammatory molecules in LCWE-treated macrophages via blocking the activation of NF-kappaB and STAT3 pathways.	TRAM 34	116-123	signal transducer and activator of transcription 3	Mus musculus	261-266
33653884-6	2021	Exogenous activation of STAT3 and 6 suppresses host cell ROS production during infection with ROP16-deficient parasites and depletion of STAT6, but not STAT3 or 5a, causes an accumulation of ROS in cells infected with wild-type parasites.	Reactive Oxygen Species	57-60	signal transducer and activator of transcription 3	Mus musculus	24-29
32295413-0	2021	Chronic Empaglifozin treatment reduces myocardial infarct size in non-diabetic mice through STAT-3 mediated protection on microvascular endothelial cells and reduction of oxidative stress.	empaglifozin	8-20	signal transducer and activator of transcription 3	Mus musculus	92-98
33711213-4	2021	The specific STAT3 inhibitor BP1-102 was also employed to verify findings from STAT3 KD experiments.	BP-1-102	29-36	signal transducer and activator of transcription 3	Mus musculus	13-18
32295413-12	2021	INNOVATION: Chronic EMPA administration reduces IS in healthy mice via STAT-3 pathway and increased survival of endothelial cells.	empagliflozin	20-24	signal transducer and activator of transcription 3	Mus musculus	71-77
32295413-13	2021	CONCLUSION: Chronic but not acute administration of EMPA reduces IS through STAT-3 activation independently of diabetes mellitus.	empagliflozin	52-56	signal transducer and activator of transcription 3	Mus musculus	76-82
33309859-6	2021	Mechanistic investigations demonstrated that IGFBP2 augmented the expression and secretion of IL-10 through STAT3 activation in PDAC cells, which induced TAM polarization toward an M2 phenotype.	tam	154-157	signal transducer and activator of transcription 3	Mus musculus	108-113
33332758-0	2021	miR-223 improves intestinal inflammation through inhibiting the IL-6/STAT3 signaling pathway in dextran sodium sulfate-induced experimental colitis.	dextran sodium sulfate	96-118	signal transducer and activator of transcription 3	Mus musculus	69-74
33653884-6	2021	Exogenous activation of STAT3 and 6 suppresses host cell ROS production during infection with ROP16-deficient parasites and depletion of STAT6, but not STAT3 or 5a, causes an accumulation of ROS in cells infected with wild-type parasites.	Reactive Oxygen Species	191-194	signal transducer and activator of transcription 3	Mus musculus	24-29
33332758-11	2021	CONCLUSIONS: The upregulation of miR-223 by agomir administration alleviated colonic inflammation in a DSS-induced colitis model, which was likely mediated by inhibiting the production of pro-inflammatory cytokines via the IL-6/STAT3 signaling pathway.	dss	103-106	signal transducer and activator of transcription 3	Mus musculus	228-233
33692217-9	2021	Knockdown of STAT3 abolished the protumor effect of TANs and TAMs on ICC.	tans	52-56	signal transducer and activator of transcription 3	Mus musculus	13-18
33523066-13	2021	EPA also inhibited NLRP3/IL-1beta and IL-6/STAT3 inflammatory pathways and up-regulated the Wnt/beta-catenin pathway.	Eicosapentaenoic Acid	0-3	signal transducer and activator of transcription 3	Mus musculus	43-48
33887899-10	2021	Exosomal miR-103a was also found to activate the JAK/STAT3 signaling pathway.	mir-103a	9-17	signal transducer and activator of transcription 3	Mus musculus	53-58
33887899-11	2021	In conclusion, exosomal miR-103a inhibited the expression of HNF4A to activate the JAK/STAT3 signaling pathway, thereby exacerbating RA in mice.	mir-103a	24-32	signal transducer and activator of transcription 3	Mus musculus	87-92
33692217-9	2021	Knockdown of STAT3 abolished the protumor effect of TANs and TAMs on ICC.	Tamoxifen	61-65	signal transducer and activator of transcription 3	Mus musculus	13-18
33739886-6	2021	Biochemically, PCB interacts with the transcription factor, SRY-related HMG-box 4 (Sox4), and then modulates its dysregulated expression and the expression of Sox4/Stat3 signaling molecules in AIA mice.	pinocembrin	15-18	signal transducer and activator of transcription 3	Mus musculus	164-169
33641239-0	2021	Binge-Like Ethanol Drinking Activates ALK Signaling and Increases the Expression of STAT3 Target Genes in the Mouse Hippocampus and Prefrontal Cortex.	Ethanol	11-18	signal transducer and activator of transcription 3	Mus musculus	84-89
33640759-8	2021	In fact, AAP mediates its anti-CSC effect via inhibition of STAT3.	Acetaminophen	9-12	signal transducer and activator of transcription 3	Mus musculus	60-65
33640759-9	2021	AAP directly binds to STAT3 with an affinity in the low micromolar range and a high degree of specificity for STAT3 relative to STAT1.	Acetaminophen	0-3	signal transducer and activator of transcription 3	Mus musculus	22-27
33640759-9	2021	AAP directly binds to STAT3 with an affinity in the low micromolar range and a high degree of specificity for STAT3 relative to STAT1.	Acetaminophen	0-3	signal transducer and activator of transcription 3	Mus musculus	110-115
33641239-3	2021	The receptor tyrosine kinase ALK activates the transcription factor STAT3 in response to ethanol in cell lines.	Ethanol	89-96	signal transducer and activator of transcription 3	Mus musculus	68-73
33641239-4	2021	Here, we demonstrate ALK activation and upregulation of known STAT3 target genes (Socs3, Gfap, and Tnfrsf1a) in the prefrontal cortex (PFC) and ventral hippocampus (HPC) of mice after 4 days of binge-like ethanol drinking.	Ethanol	205-212	signal transducer and activator of transcription 3	Mus musculus	62-67
33641239-5	2021	Mice treated with the STAT3 inhibitor stattic drank less ethanol than vehicle-treated mice, demonstrating the behavioral importance of STAT3.	stattic	38-45	signal transducer and activator of transcription 3	Mus musculus	22-27
33641239-5	2021	Mice treated with the STAT3 inhibitor stattic drank less ethanol than vehicle-treated mice, demonstrating the behavioral importance of STAT3.	stattic	38-45	signal transducer and activator of transcription 3	Mus musculus	135-140
33641239-5	2021	Mice treated with the STAT3 inhibitor stattic drank less ethanol than vehicle-treated mice, demonstrating the behavioral importance of STAT3.	Ethanol	57-64	signal transducer and activator of transcription 3	Mus musculus	22-27
33641239-6	2021	To identify novel ethanol-induced target genes downstream of the ALK and STAT3 pathway, we analyzed the NIH LINCS L1000 database for gene signature overlap between ALK inhibitor (alectinib and NVP-TAE684) and STAT3 inhibitor (niclosamide) treatments on cell lines.	Ethanol	18-25	signal transducer and activator of transcription 3	Mus musculus	73-78
33641239-6	2021	To identify novel ethanol-induced target genes downstream of the ALK and STAT3 pathway, we analyzed the NIH LINCS L1000 database for gene signature overlap between ALK inhibitor (alectinib and NVP-TAE684) and STAT3 inhibitor (niclosamide) treatments on cell lines.	Ethanol	18-25	signal transducer and activator of transcription 3	Mus musculus	209-214
33647318-9	2021	In contrast, overexpression of STAT3 diminished the effect of miR-223-3p.	mir-223-3p	62-72	signal transducer and activator of transcription 3	Mus musculus	31-36
33647318-10	2021	Taken together, the results indicate a protective role of miR-223-3p that inhibits both medial and atherosclerotic vascular calcification by regulating IL-6/STAT3 signaling mediated VSMC transdifferentiation.	mir-223-3p	58-68	signal transducer and activator of transcription 3	Mus musculus	157-162
33560543-16	2021	We demonstrated that lncRNA RMRP competitively bound to miR-613, leading to the increase of ATG3 expression and the inhibition the JAK2/STAT3 pathway, thus promoting cerebral I/R injury in mice.	mir-613	56-63	signal transducer and activator of transcription 3	Mus musculus	136-141
33748712-7	2021	These findings establish the importance of obesity-associated LIFR-alpha/JAK/STAT3 inflammatory signaling in adipocytes, blocking further adipose expansion in DIO contributing to ectopic liver triacylglyceride accumulation.	triacylglyceride	193-209	signal transducer and activator of transcription 3	Mus musculus	77-82
33708630-6	2021	Compared to the control diet-fed mice, the HFD-fed mice exhibited increased lung tumor burden and typical pro-tumorigenic STAT3 pathway activation in lung tissues after urethane administration.	Urethane	169-177	signal transducer and activator of transcription 3	Mus musculus	122-127
33309747-5	2021	The specific inhibitor AG490 was used to block the JAK2/STAT3 pathway.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	23-28	signal transducer and activator of transcription 3	Mus musculus	56-61
33347820-0	2021	Bazedoxifene exhibits anti-inflammation and anti-atherosclerotic effects via inhibition of IL-6/IL-6R/STAT3 signaling.	bazedoxifene	0-12	signal transducer and activator of transcription 3	Mus musculus	102-107
33347820-8	2021	In the ApoE-/- mice fed with HFD, daily Bazedoxifene administration effectively attenuated atherosclerotic plaque area (P<0.01), down-regulated IL-6 levels (P<0.01), decreased STAT3 phosphorylation, reduced VSMCs proliferation and increased endothelial coverage in aortic vessels.	bazedoxifene	40-52	signal transducer and activator of transcription 3	Mus musculus	176-181
34026326-9	2021	TRPML1 overexpression, downregulation of miR-204, or STAT3 pathway activation reduced the Abeta1-42-induced mitochondrial damage, along with ROS production and mitochondrial autophagy in vivo and in vitro.	Reactive Oxygen Species	141-144	signal transducer and activator of transcription 3	Mus musculus	53-58
34026326-10	2021	Silencing of miR-204 could upregulate TRPML1 expression, thus suppressing ROS production and mitochondrial autophagy in AD through STAT3 pathway.	Reactive Oxygen Species	74-77	signal transducer and activator of transcription 3	Mus musculus	131-136
33537886-9	2021	Taken together, G-Rg2 and -Rh1 exerts a protective effect on liver function by increasing antioxidant through Nrf2 and anti-inflammatory activities through STAT3/TAK1 and NF-kappaB signaling pathways in liver cells and macrophages.	ginsenoside Rg2	16-21	signal transducer and activator of transcription 3	Mus musculus	156-161
33633749-8	2021	Moreover, 15d-PGJ2 treated mice exhibited the significantly reduced proportion of macrophages expressing the pro-inflammatory cytokine, IL-6 with concomitant suppression of STAT3 phosphorylation in the colonic mucosa of mice administered 2.5% DSS in drinking water.	15-deoxy-delta(12,14)-prostaglandin J2	10-18	signal transducer and activator of transcription 3	Mus musculus	173-178
33537886-9	2021	Taken together, G-Rg2 and -Rh1 exerts a protective effect on liver function by increasing antioxidant through Nrf2 and anti-inflammatory activities through STAT3/TAK1 and NF-kappaB signaling pathways in liver cells and macrophages.	2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone	26-30	signal transducer and activator of transcription 3	Mus musculus	156-161
33140855-0	2021	DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation.	deoxyguanosine triphosphate	0-3	signal transducer and activator of transcription 3	Mus musculus	90-95
33140855-0	2021	DGT, a novel heterocyclic diterpenoid, effectively suppresses psoriasis via inhibition of STAT3 phosphorylation.	Diterpenes	26-37	signal transducer and activator of transcription 3	Mus musculus	90-95
33140855-10	2021	Furthermore, our results identified that DGT prevented these pathological processes of psoriasis through suppression of STAT3 phosphorylation.	deoxyguanosine triphosphate	41-44	signal transducer and activator of transcription 3	Mus musculus	120-125
33376516-10	2021	Furthermore, following 5-AIQ treatment, the main components of the PARP/NF-kappaB and STAT3 pathways were downregulated.	5-aminoisoquinolinone	23-28	signal transducer and activator of transcription 3	Mus musculus	86-91
33634976-17	2021	PF00562271, a specific FAK inhibitor, blocked MFG-E8-induced STAT3 phosphorylation.	PF-00562271	0-10	signal transducer and activator of transcription 3	Mus musculus	61-66
33376516-11	2021	Collectively, these results demonstrate that the PARP-1 inhibitor, 5-AIQ, may suppress intestinal inflammation and protect the colonic mucosa by modulating Treg/Th17 immune balance and inhibiting PARP-1/NF-kappaB and STAT3 signaling pathways in mice with experimental colitis.	5-aminoisoquinolinone	67-72	signal transducer and activator of transcription 3	Mus musculus	217-222
33474811-0	2021	Pharmacological inhibition of STAT3 by BP-1-102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response.	BP-1-102	39-47	signal transducer and activator of transcription 3	Mus musculus	30-35
32579788-7	2021	Mechanistically, we show that niclosamide decreases beta-catenin level and activity, and inhibits phosphorylation of STAT3 and mTORC1 substrate 70S6K.	Niclosamide	30-41	signal transducer and activator of transcription 3	Mus musculus	117-122
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	Flavonoids	8-17	signal transducer and activator of transcription 3	Mus musculus	118-123
33340783-0	2021	Natural flavonoid pectolinarigenin alleviated kidney fibrosis via inhibiting the activation of TGFbeta/SMAD3 and JAK2/STAT3 signaling.	pectolinarigenin	18-34	signal transducer and activator of transcription 3	Mus musculus	118-123
33340783-8	2021	In summary, our results suggested that pectolinarigenin alleviated tubulointerstitial fibrosis by inhibiting the activation of SMAD3 and STAT3 signaling.	pectolinarigenin	39-55	signal transducer and activator of transcription 3	Mus musculus	137-142
33410581-0	2021	Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation.	Sorafenib	105-114	signal transducer and activator of transcription 3	Mus musculus	134-139
33410581-9	2021	In addition, the hepatic inflammatory microenvironment contributed to sorafenib resistance through the anti-apoptotic protein mediated by STAT3, and STAT3 inhibitor S3I-201 significantly improved sorafenib efficacy impaired by liver inflammation.	Sorafenib	70-79	signal transducer and activator of transcription 3	Mus musculus	138-143
33410581-9	2021	In addition, the hepatic inflammatory microenvironment contributed to sorafenib resistance through the anti-apoptotic protein mediated by STAT3, and STAT3 inhibitor S3I-201 significantly improved sorafenib efficacy impaired by liver inflammation.	Sorafenib	196-205	signal transducer and activator of transcription 3	Mus musculus	138-143
33410581-9	2021	In addition, the hepatic inflammatory microenvironment contributed to sorafenib resistance through the anti-apoptotic protein mediated by STAT3, and STAT3 inhibitor S3I-201 significantly improved sorafenib efficacy impaired by liver inflammation.	Sorafenib	196-205	signal transducer and activator of transcription 3	Mus musculus	149-154
33410581-11	2021	Above all, we concluded that the hepatic inflammatory microenvironment promotes intrahepatic HCC growth, metastasis and sorafenib resistance through activation of STAT3.	Sorafenib	120-129	signal transducer and activator of transcription 3	Mus musculus	163-168
33309720-0	2021	Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl/thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.	Hyaluronic Acid	39-50	signal transducer and activator of transcription 3	Mus musculus	14-19
33474811-1	2021	As an inhibitor of STAT3, BP-1-102 can regulate the inflammation response caused by vascular smooth muscle cells (VSMCs) by inhibiting the JAK/STAT3/NF-kappaB pathway, thereby attenuating the symptoms of intracranial aneurysm (IA).	BP-1-102	26-34	signal transducer and activator of transcription 3	Mus musculus	19-24
33474811-1	2021	As an inhibitor of STAT3, BP-1-102 can regulate the inflammation response caused by vascular smooth muscle cells (VSMCs) by inhibiting the JAK/STAT3/NF-kappaB pathway, thereby attenuating the symptoms of intracranial aneurysm (IA).	BP-1-102	26-34	signal transducer and activator of transcription 3	Mus musculus	143-148
33474811-7	2021	In the IA model, BP-1-102 can reduce the expression of inflammatory factors and MMPs bound to NF-kappaB by inhibiting the activation of the JAK/STAT3/NF-kappaB pathway proteins, and then restore the vascular wall elastin to reduce blood pressure, thereby treating aneurysm.	BP-1-102	17-25	signal transducer and activator of transcription 3	Mus musculus	144-149
32891820-0	2021	Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6/STAT3 signaling pathway.	Dextran Sulfate	32-54	signal transducer and activator of transcription 3	Mus musculus	131-136
33420372-5	2021	N4 blocked STAT3 and phospho-tyrosine (pTyr) peptide interactions in fluorescence polarization (FP) assay, specifically abolished phosphor-STAT3 (Tyr705), and suppressed expression of STAT3 downstream genes.	n4	0-2	signal transducer and activator of transcription 3	Mus musculus	11-16
33420372-5	2021	N4 blocked STAT3 and phospho-tyrosine (pTyr) peptide interactions in fluorescence polarization (FP) assay, specifically abolished phosphor-STAT3 (Tyr705), and suppressed expression of STAT3 downstream genes.	n4	0-2	signal transducer and activator of transcription 3	Mus musculus	139-144
33420372-5	2021	N4 blocked STAT3 and phospho-tyrosine (pTyr) peptide interactions in fluorescence polarization (FP) assay, specifically abolished phosphor-STAT3 (Tyr705), and suppressed expression of STAT3 downstream genes.	n4	0-2	signal transducer and activator of transcription 3	Mus musculus	139-144
33420372-6	2021	The mechanism involved the direct binding of N4 to the STAT3 SH2 domain, thereby, the STAT3 dimerization, STAT3-EGFR, and STAT3-NF-kappaB cross-talk were efficiently inhibited.	n4	45-47	signal transducer and activator of transcription 3	Mus musculus	55-60
33420372-6	2021	The mechanism involved the direct binding of N4 to the STAT3 SH2 domain, thereby, the STAT3 dimerization, STAT3-EGFR, and STAT3-NF-kappaB cross-talk were efficiently inhibited.	n4	45-47	signal transducer and activator of transcription 3	Mus musculus	86-91
33420372-6	2021	The mechanism involved the direct binding of N4 to the STAT3 SH2 domain, thereby, the STAT3 dimerization, STAT3-EGFR, and STAT3-NF-kappaB cross-talk were efficiently inhibited.	n4	45-47	signal transducer and activator of transcription 3	Mus musculus	86-91
33420372-6	2021	The mechanism involved the direct binding of N4 to the STAT3 SH2 domain, thereby, the STAT3 dimerization, STAT3-EGFR, and STAT3-NF-kappaB cross-talk were efficiently inhibited.	n4	45-47	signal transducer and activator of transcription 3	Mus musculus	86-91
33459594-4	2021	Transcriptome analyses revealed that PC-specific STAT3 knockout (STAT3PKO) results in transcriptional changes that lead to an increase in the expression of glutamate receptors.	Glutamic Acid	156-165	signal transducer and activator of transcription 3	Mus musculus	49-54
33536944-5	2020	We found that chronic alcohol exposure led to a significant reduction in intestinal IFN-gamma levels compared to a control; the protein levels of phosphorylated STAT1 (p-STAT1) and p-STAT3 were both declined by alcohol.	Alcohols	22-29	signal transducer and activator of transcription 3	Mus musculus	183-188
33536944-5	2020	We found that chronic alcohol exposure led to a significant reduction in intestinal IFN-gamma levels compared to a control; the protein levels of phosphorylated STAT1 (p-STAT1) and p-STAT3 were both declined by alcohol.	Alcohols	211-218	signal transducer and activator of transcription 3	Mus musculus	183-188
33536944-13	2020	Taken together, the study reveals that IFN-gamma is critically involved in the regulation of AMPs through regulation of STAT1 and STAT3; impaired IFN-gamma-STAT signaling provides an explanation for alcohol-induced gut antimicrobial dysfunction and microbial dysbiosis.	Alcohols	199-206	signal transducer and activator of transcription 3	Mus musculus	130-135
33527019-11	2021	Finally, Schisandrin C inhibited the expression of Swiprosin-1, IFN-gamma-Rbeta, phospho-Janus kinase 2 (p-JAK2), phospho-signal transducer and activator of transcription 1 (p-STAT1), and p-STAT3, in both DN model mice and high-glucose-stimulated RAW264.7 cells.	schizandrin C	9-22	signal transducer and activator of transcription 3	Mus musculus	190-195
33511217-0	2021	Tofacitinib Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Blocking the JAK-STAT1/STAT3 Signaling Pathway.	tofacitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	97-102
33511217-8	2021	These results may be associated with the inhibitory effect of TOFA on the JAK-STAT1/STAT3 pathway, which was significantly activated by LPS challenge.	tofacitinib	62-66	signal transducer and activator of transcription 3	Mus musculus	84-89
32948825-8	2021	In db/db mice, TUG-891 administration significantly inhibited the mRNA and protein expression of fibronectin, collagen IV, alpha-SMA, TGF-beta1, and IL-6, and downregulated the phosphorylation of Smad3 and STAT3 to alleviate glomerulosclerosis.	3-(4-((4-fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)phenyl)propanoic acid	15-22	signal transducer and activator of transcription 3	Mus musculus	206-211
33525658-0	2021	HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy.	N-(2-hydroxypropyl)methacrylamide	0-4	signal transducer and activator of transcription 3	Mus musculus	31-36
33525658-0	2021	HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy.	cucurbitacin D	47-61	signal transducer and activator of transcription 3	Mus musculus	31-36
33501731-0	2021	Photobiomodulation Therapy for Thrombocytopenia by Upregulating Thrombopoietin Expression via the ROS-dependent Src/ERK/STAT3 Signaling Pathway.	ros	98-101	signal transducer and activator of transcription 3	Mus musculus	120-125
33495423-14	2021	Conclusions: Exogenous rIL-22 attenuates L-arginine-induced acute pancreatitis and intestinal mucosa injury in mice, via activating STAT3 signaling pathway and enhancing the expression of antimicrobial peptides and antiapoptotic genes.	Arginine	41-51	signal transducer and activator of transcription 3	Mus musculus	132-137
33491667-4	2021	STAT3, c-Myc, and Gp130 targeting peptides by attaching phosphorothioated (PS) polymer backbone to peptides.	Peptides	34-42	signal transducer and activator of transcription 3	Mus musculus	0-5
33491667-4	2021	STAT3, c-Myc, and Gp130 targeting peptides by attaching phosphorothioated (PS) polymer backbone to peptides.	phosphorothioated	56-73	signal transducer and activator of transcription 3	Mus musculus	0-5
33491667-4	2021	STAT3, c-Myc, and Gp130 targeting peptides by attaching phosphorothioated (PS) polymer backbone to peptides.	ps	75-77	signal transducer and activator of transcription 3	Mus musculus	0-5
33491667-4	2021	STAT3, c-Myc, and Gp130 targeting peptides by attaching phosphorothioated (PS) polymer backbone to peptides.	Polymers	79-86	signal transducer and activator of transcription 3	Mus musculus	0-5
33491667-4	2021	STAT3, c-Myc, and Gp130 targeting peptides by attaching phosphorothioated (PS) polymer backbone to peptides.	Peptides	99-107	signal transducer and activator of transcription 3	Mus musculus	0-5
33485710-0	2021	Dietary magnesium restriction affects hematopoiesis and triggers neutrophilia by increasing STAT-3 expression and G-CSF production.	Magnesium	8-17	signal transducer and activator of transcription 3	Mus musculus	92-98
33485710-11	2021	Moreover, the Mg2+ restricted group showed increased expression of CSF3 and CEBPalpha genes as well as increased production of G-CSF in association with increased expression of STAT3 protein.	magnesium ion	14-18	signal transducer and activator of transcription 3	Mus musculus	177-182
33485710-12	2021	CONCLUSION: Short-term dietary restriction of Mg2+ induces granulopoiesis by increasing G-CSF production and activating the CEBPalpha and STAT-3 pathways, resulting in neutrophilia in peripheral blood.	magnesium ion	46-50	signal transducer and activator of transcription 3	Mus musculus	138-144
33428604-6	2021	Furthermore, IL-6 treatment significantly activated the PI3K/Akt and STAT3 signaling pathways in the myocardium during MI/R, and the specific inhibitors wortmannin (specific phosphoinositide 3-kinase inhibitor) and Stattic (specific STAT3 inhibitor) substantially abolished HIF2alpha/IL-6-induced cardioprotection.	Wortmannin	153-163	signal transducer and activator of transcription 3	Mus musculus	69-74
33413331-0	2021	Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma.	rhyncophylline	85-100	signal transducer and activator of transcription 3	Mus musculus	38-43
33413331-11	2021	Furthermore, rhynchophylline suppressed the JAK2/STAT3 signaling pathway, which was activated in asthma.	rhyncophylline	13-28	signal transducer and activator of transcription 3	Mus musculus	49-54
33413331-12	2021	In vitro study showed that rhynchophylline suppressed ASMC autophagy through suppressing the activation of JAK2/STAT3 signal.	rhyncophylline	27-42	signal transducer and activator of transcription 3	Mus musculus	112-117
33413331-12	2021	In vitro study showed that rhynchophylline suppressed ASMC autophagy through suppressing the activation of JAK2/STAT3 signal.	asmc	54-58	signal transducer and activator of transcription 3	Mus musculus	112-117
33413331-13	2021	CONCLUSIONS: Our study demonstrated that rhynchophylline can alleviate asthma through suppressing autophagy in asthma, and that JAK2/STAT3 signal was involved in this effect of rhynchophylline.	rhyncophylline	177-192	signal transducer and activator of transcription 3	Mus musculus	133-138
33419132-8	2021	These results collectively demonstrate that CTXA has strong anti-adipogenic and anti-inflammatory effects on 3T3-L1 cells through control of the expression and phosphorylation levels of C/EBP-alpha, PPAR-gamma, FAS, ACC, perilipin A, STAT-3/5, AMPK, and iNOS.	cudratricusxanthone A	44-48	signal transducer and activator of transcription 3	Mus musculus	234-242
33466434-11	2021	Furthermore, treatment with a STAT3 inhibitor, S3I-201, caused mouse embryonic arrest at the zygote and two-cell stages.	NSC 74859	47-54	signal transducer and activator of transcription 3	Mus musculus	30-35
33431808-10	2021	Both cancer cells and in vivo tumor xenografts showed that the combined inhibition of PI3K/AKT/mTOR and STAT3 activity enhanced the inhibitory effect of BEZ235 on the proliferation of PTEN-deficient cancer cells.	dactolisib	153-159	signal transducer and activator of transcription 3	Mus musculus	104-109
32891820-10	2021	Activation of the IL-6/STAT3 pathway was also suppressed by BTW treatment.	BTW	60-63	signal transducer and activator of transcription 3	Mus musculus	23-28
32891820-15	2021	CONCLUSION: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.	BTW	12-15	signal transducer and activator of transcription 3	Mus musculus	271-276
32891820-15	2021	CONCLUSION: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.	BTW	121-124	signal transducer and activator of transcription 3	Mus musculus	271-276
33098244-8	2021	AG490 downregulated the phosphorylated activation of JAK3 and their downstream STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	79-84
33569454-8	2021	LIF was observed to block these events; however, the administration of the STAT3 inhibitor S3I201 reversed the beneficial effects of LIF on H2O2-triggered apoptosis and ROS production.	NSC 74859	91-97	signal transducer and activator of transcription 3	Mus musculus	75-80
33569454-8	2021	LIF was observed to block these events; however, the administration of the STAT3 inhibitor S3I201 reversed the beneficial effects of LIF on H2O2-triggered apoptosis and ROS production.	Hydrogen Peroxide	140-144	signal transducer and activator of transcription 3	Mus musculus	75-80
33569454-8	2021	LIF was observed to block these events; however, the administration of the STAT3 inhibitor S3I201 reversed the beneficial effects of LIF on H2O2-triggered apoptosis and ROS production.	Reactive Oxygen Species	169-172	signal transducer and activator of transcription 3	Mus musculus	75-80
33314735-11	2021	In addition, blocking CME in the refractory cell lines led to downregulate of p-STAT3 and inhibit nuclear localization of STAT3 in vivo, combination treatment with gefitinib and a CME inhibitor resulted in tumor regression accompanying apoptosis in xenograft mouse models.	Gefitinib	164-173	signal transducer and activator of transcription 3	Mus musculus	80-85
33314735-11	2021	In addition, blocking CME in the refractory cell lines led to downregulate of p-STAT3 and inhibit nuclear localization of STAT3 in vivo, combination treatment with gefitinib and a CME inhibitor resulted in tumor regression accompanying apoptosis in xenograft mouse models.	Gefitinib	164-173	signal transducer and activator of transcription 3	Mus musculus	122-127
33091599-0	2021	The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling.	sesquiterpene lactone	4-25	signal transducer and activator of transcription 3	Mus musculus	106-111
33091599-0	2021	The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling.	eupatolide	26-36	signal transducer and activator of transcription 3	Mus musculus	106-111
33091599-1	2021	We aimed to evaluate the role of a natural sesquiterpene lactone, eupatolide, in non-small-cell lung cancer (NSCLC) and further explore its underlying mechanism on regulating the activation of signal transducer and activator of transcription 3 (STAT3), which is thought to have carcinogenic function in a variety of malignancies including lung cancer.	sesquiterpene lactone	43-64	signal transducer and activator of transcription 3	Mus musculus	245-250
33091599-1	2021	We aimed to evaluate the role of a natural sesquiterpene lactone, eupatolide, in non-small-cell lung cancer (NSCLC) and further explore its underlying mechanism on regulating the activation of signal transducer and activator of transcription 3 (STAT3), which is thought to have carcinogenic function in a variety of malignancies including lung cancer.	eupatolide	66-76	signal transducer and activator of transcription 3	Mus musculus	193-243
33091599-1	2021	We aimed to evaluate the role of a natural sesquiterpene lactone, eupatolide, in non-small-cell lung cancer (NSCLC) and further explore its underlying mechanism on regulating the activation of signal transducer and activator of transcription 3 (STAT3), which is thought to have carcinogenic function in a variety of malignancies including lung cancer.	eupatolide	66-76	signal transducer and activator of transcription 3	Mus musculus	245-250
33091599-9	2021	Furthermore, eupatolide induced apoptosis by suppressing the activation of STAT3 in NSCLC cells.	eupatolide	13-23	signal transducer and activator of transcription 3	Mus musculus	75-80
33091599-10	2021	Sustained activation or knockdown of STAT3 suppressed and enhanced the activity of eupatolide, respectively.	eupatolide	83-93	signal transducer and activator of transcription 3	Mus musculus	37-42
33091599-11	2021	This paper is the first to report that eupatolide could effectively inhibit NSCLC progression, suggesting that eupatolide might be utilized as a novel STAT3 inhibitor for treating NSCLC.	eupatolide	39-49	signal transducer and activator of transcription 3	Mus musculus	151-156
33091599-11	2021	This paper is the first to report that eupatolide could effectively inhibit NSCLC progression, suggesting that eupatolide might be utilized as a novel STAT3 inhibitor for treating NSCLC.	eupatolide	111-121	signal transducer and activator of transcription 3	Mus musculus	151-156
33506931-0	2021	Sodium butyrate relieves lung ischemia-reperfusion injury by inhibiting NF-kappaB and JAK2/STAT3 signaling pathways.	Butyric Acid	0-15	signal transducer and activator of transcription 3	Mus musculus	91-96
33176070-0	2021	Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation.	Sorafenib	0-9	signal transducer and activator of transcription 3	Mus musculus	111-116
33176070-11	2021	In conclusion, sorafenib and CuB exert synergistic antitumor effects through a pathway that may involve STAT3 phosphorylation, and this may represent a promising therapeutic approach for HCC treatment.	Sorafenib	15-24	signal transducer and activator of transcription 3	Mus musculus	104-109
33506931-9	2021	The activities of NF-kappaB and JAK2/STAT3 signaling pathways were significantly increased in lung tissue after IR, whereas NaB inhibited the activity of NF-kappaB and JAK2/STAT3 signaling pathways.	nab	124-127	signal transducer and activator of transcription 3	Mus musculus	173-178
33506931-10	2021	CONCLUSIONS: NaB relieves LIRI by inhibiting NF-kappaB and JAK2/STAT3 signaling pathways to reduce inflammation and oxidative stress levels in lung tissue of mice after IR.	nab	13-16	signal transducer and activator of transcription 3	Mus musculus	64-69
33280239-6	2021	The effects of C5a and short-chain fatty acids (SCFAs) on the signal transducer and activator of transcription 3 (STAT3) pathway were examined in vitro.	Fatty Acids, Volatile	23-46	signal transducer and activator of transcription 3	Mus musculus	114-119
32098538-7	2021	In terms of mechanism, we proved that MFG-E8 regulated OGD-induced microglial M1/M2 polarization by inhibiting p-STAT3 and SOCS3 expressions, which was reversed by STAT3 activator (Colivelin TFA).	Trifluoroacetic Acid	191-194	signal transducer and activator of transcription 3	Mus musculus	164-169
33277208-14	2021	Further, the IL6/STAT3/P65 signaling pathway was inhibited in the EVO group.	evodiamine	66-69	signal transducer and activator of transcription 3	Mus musculus	17-22
33614732-7	2021	Furthermore, simultaneous administration of nintedanib and gefitinib was more potent in inhibiting UUO-induced renal phosphorylation of signal transducer and activator of transcription-3 (STAT3), nuclear factor-kappaB, and Smad-3 compared with monotherapy.	nintedanib	44-54	signal transducer and activator of transcription 3	Mus musculus	136-186
33614732-7	2021	Furthermore, simultaneous administration of nintedanib and gefitinib was more potent in inhibiting UUO-induced renal phosphorylation of signal transducer and activator of transcription-3 (STAT3), nuclear factor-kappaB, and Smad-3 compared with monotherapy.	nintedanib	44-54	signal transducer and activator of transcription 3	Mus musculus	188-193
33614732-7	2021	Furthermore, simultaneous administration of nintedanib and gefitinib was more potent in inhibiting UUO-induced renal phosphorylation of signal transducer and activator of transcription-3 (STAT3), nuclear factor-kappaB, and Smad-3 compared with monotherapy.	Gefitinib	59-68	signal transducer and activator of transcription 3	Mus musculus	136-186
33614732-7	2021	Furthermore, simultaneous administration of nintedanib and gefitinib was more potent in inhibiting UUO-induced renal phosphorylation of signal transducer and activator of transcription-3 (STAT3), nuclear factor-kappaB, and Smad-3 compared with monotherapy.	Gefitinib	59-68	signal transducer and activator of transcription 3	Mus musculus	188-193
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	68-73
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	111-116
32474674-11	2021	Importantly, calycosin improved ERbeta protein expression, JAK2 and STAT3 mRNA expressions, p-JAK2/JAK2, and p-STAT3/STAT3 relative protein expressions.	7,3'-dihydroxy-4'-methoxyisoflavone	13-22	signal transducer and activator of transcription 3	Mus musculus	111-116
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	signal transducer and activator of transcription 3	Mus musculus	268-273
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	signal transducer and activator of transcription 3	Mus musculus	268-273
32474674-13	2021	Calycosin significantly inhibits liver fibrosis in mice, and its mechanism may involve the following: calycosin inhibits oxidative stress; calycosin inhibits collagen synthesis and balances MMP-1/TIMP-1 system; calycosin increases ERbeta expression and activates JAK2-STAT3 pathway.	7,3'-dihydroxy-4'-methoxyisoflavone	139-148	signal transducer and activator of transcription 3	Mus musculus	268-273
33177649-6	2021	Colon tumors from IL-17RD-deficient mice are characterized by a strong enrichment in inflammation-related gene signatures, elevated expression of pro-inflammatory tumorigenic cytokines, such as IL-17A and IL-6, and increased STAT3 tyrosine phosphorylation.	Tyrosine	231-239	signal transducer and activator of transcription 3	Mus musculus	225-230
33144092-8	2021	Furthermore, these effects were related to increased phosphorylation of JAK2-STAT3 stimulated by chemerin, which could be inhibited by the CMKLR1 specific inhibitor alpha-NETA.	(2-(4,7-biscarboxymethyl(1,4,7)triazacyclonona-1-yl-ethyl)carbonylmethylamino)acetic acid	165-175	signal transducer and activator of transcription 3	Mus musculus	77-82
33080566-0	2021	Effect of the isoflavone corylin from cullen corylifolium on colorectal cancer growth, by targeting the STAT3 signaling pathway.	Isoflavones	14-24	signal transducer and activator of transcription 3	Mus musculus	104-109
33080566-14	2021	It is conceivable that corylin should be further explored as a unique STAT3 inhibitor in antitumor therapy.	corylin	23-30	signal transducer and activator of transcription 3	Mus musculus	70-75
33370269-0	2020	Increased prostaglandin-D2 in male STAT3-deficient hearts shifts cardiac progenitor cells from endothelial to white adipocyte differentiation.	Prostaglandin D2	10-26	signal transducer and activator of transcription 3	Mus musculus	35-40
33370269-14	2020	Causally involved is the impaired AR signaling in absence of STAT3, which reduces the expression of the PG-degrading enzyme HPGD.	Prostaglandins	104-106	signal transducer and activator of transcription 3	Mus musculus	61-66
33374928-0	2020	Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis.	Oils, Volatile	14-27	signal transducer and activator of transcription 3	Mus musculus	104-109
33374928-0	2020	Inhalation of Essential Oil from Mentha piperita Ameliorates PM10-Exposed Asthma by Targeting IL-6/JAK2/STAT3 Pathway Based on a Network Pharmacological Analysis.	pm10	61-65	signal transducer and activator of transcription 3	Mus musculus	104-109
33374928-10	2020	PM10-induced phosphorylation of JAK2 and STAT3 was significantly decreased by MEO.	pm10	0-4	signal transducer and activator of transcription 3	Mus musculus	41-46
33374928-11	2020	Collectively, MEO may have an inhibitory effect on asthma under the condition of PM10 exposure through the IL-6/JAK2/STAT3 signaling pathway.	pm10	81-85	signal transducer and activator of transcription 3	Mus musculus	117-122
33332446-5	2020	The Stat3-C3S cells differed from WT-Stat3 cells in morphology, proliferation and resistance to oxidative stress; in response to cytokine stimulation, they displayed elevated Stat3 tyrosine phosphorylation and Socs3 expression, implying that Stat3-C3S is insensitive to oxidative inhibition.	Tyrosine	181-189	signal transducer and activator of transcription 3	Mus musculus	4-9
33327484-9	2020	More importantly, HNC0014 treatment significantly delayed tumor growth in a syngeneic mouse HNSCC model, elicited an antitumor immune profile, and reduced the total c-Met, STAT3, and their phosphorylated forms, PD-L1 and CD44, contents in serum exosomes.	hnc0014	18-25	signal transducer and activator of transcription 3	Mus musculus	172-177
33363184-10	2020	Parallel to down-regulation of the inflammatory cytokines, the fecal lipocalin 2, p-P65, p-STAT3, and neutrophil accumulation were also decreased in TS-treated mice.	ts	149-151	signal transducer and activator of transcription 3	Mus musculus	91-96
33456673-12	2020	In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid.	alanylglutamine	30-45	signal transducer and activator of transcription 3	Mus musculus	160-165
33456673-12	2020	In contrast to the OVA group, Alanylglutamine activated the protein expression of P-AMPK/AMPK and inhibited the protein expression of P-mTOR/mTOR, P-P65/P65, P-STAT3/STAT3, P-IKKbeta/IKKbeta, TGF-beta, and IL-1beta, with similar effects from butyric acid.	alanylglutamine	30-45	signal transducer and activator of transcription 3	Mus musculus	166-171
33828598-0	2020	Alantolactone inhibits stem-like cell phenotype, chemoresistance and metastasis in PC3 cells through STAT3 signaling pathway.	alantolactone	0-13	signal transducer and activator of transcription 3	Mus musculus	101-106
33158962-8	2020	Finally, exogenous E2 administration fully rescued the compromised JAK-STAT3 pathway and reactive astrogliosis, and reversed the enhanced neuronal damage and microglial activation in the GFAP-ARO-KO mice after GCI - suggesting that the defects in the KO mice are due to a loss of E2 rather than an increase in precursor androgens.	Estradiol	19-21	signal transducer and activator of transcription 3	Mus musculus	71-76
33158962-12	2020	Transcriptome analysis further revealed that astrocyte-derived E2 was critical for the induction of the JAK-STAT3 signaling pathway, as well as the A2 reactive astrocyte phenotype after ischemia.	Estradiol	63-65	signal transducer and activator of transcription 3	Mus musculus	108-113
33372604-10	2020	Mechanistically, M2-TAM-derived IL-10 promoted the malignant properties of ICC cells through STAT3 signaling.	Tamoxifen	20-23	signal transducer and activator of transcription 3	Mus musculus	93-98
33324056-0	2020	Treatment of Colon Cancer by Degradable rrPPC Nano-Conjugates Delivered STAT3 siRNA.	rrppc	40-45	signal transducer and activator of transcription 3	Mus musculus	72-77
33103445-6	2020	ACY-1215 treatment also suppressed phosphorylation of epidermal growth factor receptor (EGFR) and several signaling molecules associated with renal fibrogenesis, including AKT, signal transducer and activator of transcription 3 and nuclear factor kappa light chain enhancer of activated B cells in the injured kidney.	ricolinostat	0-8	signal transducer and activator of transcription 3	Mus musculus	177-227
33007409-8	2020	Our data display that ITK signaling is involved in IMQ-induced psoriatic inflammation as paralleled by enhancement of p-ITK, NFATc1, p-NFkB and p-STAT3 in CD4+ T cells.	Imiquimod	51-54	signal transducer and activator of transcription 3	Mus musculus	146-151
33006786-0	2020	Enhanced anti-tumor effects of the PD-1 blockade combined with a highly absorptive form of curcumin targeting STAT3.	Curcumin	91-99	signal transducer and activator of transcription 3	Mus musculus	110-115
33006786-9	2020	These results indicate that curcumin augments the induction of tumor antigen-specific T cells by restoring the T cell stimulatory activity of DCs targeting activated STAT3 in both cancer cells and immune cells.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	166-171
32719938-9	2020	TEPP-46 treatment was found to improve hypoxia-induced pulmonary artery remodelling and right heart function in mice, and the link between PKM2 and STAT3 was also confirmed in vivo.	TEPP-46	0-7	signal transducer and activator of transcription 3	Mus musculus	148-153
32943458-11	2020	Preclinical data provide evidence that ASO-mediated inhibition of STAT3 in the immune compartment is sufficient to remodel the TME and enhance the activity of checkpoint blockade without direct STAT3 inhibition in tumor cells.	Oligonucleotides, Antisense	39-42	signal transducer and activator of transcription 3	Mus musculus	66-71
32943458-11	2020	Preclinical data provide evidence that ASO-mediated inhibition of STAT3 in the immune compartment is sufficient to remodel the TME and enhance the activity of checkpoint blockade without direct STAT3 inhibition in tumor cells.	Oligonucleotides, Antisense	39-42	signal transducer and activator of transcription 3	Mus musculus	194-199
33185634-6	2020	Computational modeling showed that S1 and S2 could form hydrogen bonds with the SH2 domain of STAT3.	Hydrogen	56-64	signal transducer and activator of transcription 3	Mus musculus	94-99
33096140-6	2020	Our results show that intraperitoneal injection of Stattic, a molecule that selectively inhibits the activation of STAT3, decreases LPS-induced microglial activation in the hippocampus.	stattic	51-58	signal transducer and activator of transcription 3	Mus musculus	115-120
32653978-0	2020	Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells.	Doxorubicin	103-114	signal transducer and activator of transcription 3	Mus musculus	26-31
32653978-2	2020	Here, we studied the effect of Stattic (STAT3 inhibitor) loaded in nanostructured lipid carriers (NLCs) on enhancing the efficacy, cytotoxicity, and induction of apoptosis of doxorubicin in B16F10 mouse melanoma cancer cell.	stattic	31-38	signal transducer and activator of transcription 3	Mus musculus	40-45
32653978-2	2020	Here, we studied the effect of Stattic (STAT3 inhibitor) loaded in nanostructured lipid carriers (NLCs) on enhancing the efficacy, cytotoxicity, and induction of apoptosis of doxorubicin in B16F10 mouse melanoma cancer cell.	Doxorubicin	175-186	signal transducer and activator of transcription 3	Mus musculus	40-45
32653978-6	2020	Real-time RT-PCR was applied to measure the effects of doxorubicin and/or Stattic on key apoptotic genes such as Bad, Survivin, HIF1, and STAT3.	Doxorubicin	55-66	signal transducer and activator of transcription 3	Mus musculus	138-143
33115265-0	2020	Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.	Oxygen	160-166	signal transducer and activator of transcription 3	Mus musculus	41-46
33115265-0	2020	Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy.	Oxygen	160-166	signal transducer and activator of transcription 3	Mus musculus	49-99
33115265-5	2020	Pharmacological inhibition of STAT3 reduced the load of IB4+ cells in the hyaloid vasculature and significantly reduced the formation of pathogenic neovascular tufts during oxygen-induced retinopathy, leading to improved long-term visual outcomes (ie, increased retinal thickness and scotopic b-wave electroretinogram responses).	Oxygen	173-179	signal transducer and activator of transcription 3	Mus musculus	30-35
33378042-12	2020	Furthermore, miR-135a-5p mimic or sh-CXCL12 could result in the suppressed expression of p-JAK2 and p-STAT3 (all p<0.05).	mir-135a-5p	13-24	signal transducer and activator of transcription 3	Mus musculus	102-107
33378042-13	2020	Compared with miR-135a-5p mimic +DMSO group, the expression of JAK2 and STAT3 in miR-135a-5p mimic +RO8191 group had no significant change (p>0.05); the expression of p-JAK2 and p-STAT3 was increased (all p<0.05), suggesting that miR-135a-5p negatively regulated the expression of CXCL12 and inhibited the activation of JAK-STAT signaling pathway.	Dimethyl Sulfoxide	33-37	signal transducer and activator of transcription 3	Mus musculus	72-77
33335525-11	2020	L-AST treatment reduced transcriptional activity of STAT3 and NF-kappaB in PA-induced skin tissues.	l-ast	0-5	signal transducer and activator of transcription 3	Mus musculus	52-57
33335525-11	2020	L-AST treatment reduced transcriptional activity of STAT3 and NF-kappaB in PA-induced skin tissues.	phthalic anhydride	75-77	signal transducer and activator of transcription 3	Mus musculus	52-57
32725513-0	2020	Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3.	panaxatriol	0-11	signal transducer and activator of transcription 3	Mus musculus	142-147
32725513-0	2020	Panaxatriol Saponins Promote M2 Polarization of BV2 Cells to Reduce Inflammation and Apoptosis after Glucose/Oxygen Deprivation by Activating STAT3.	Saponins	12-20	signal transducer and activator of transcription 3	Mus musculus	142-147
33069927-3	2020	In this article, we describe IBI112, a highly potent anti-IL-23 monoclonal antibody under clinical development, which efficiently neutralizes IL23p19, a subunit of IL-23, to abrogate IL-23 binding to its receptor and block downstream signal transducer and activator of transcription 3 (STAT3) phosphorylation.	ibi112	29-35	signal transducer and activator of transcription 3	Mus musculus	234-284
33069927-3	2020	In this article, we describe IBI112, a highly potent anti-IL-23 monoclonal antibody under clinical development, which efficiently neutralizes IL23p19, a subunit of IL-23, to abrogate IL-23 binding to its receptor and block downstream signal transducer and activator of transcription 3 (STAT3) phosphorylation.	ibi112	29-35	signal transducer and activator of transcription 3	Mus musculus	286-291
32424937-4	2020	Therefore, we silenced STAT3 upstream molecules including the S1PR1 and GP130 molecules in cancer cells using small interfering RNA (siRNA)-loaded alginate-conjugated trimethyl chitosan (ATMC) nanoparticles (NPs).	Alginates	147-155	signal transducer and activator of transcription 3	Mus musculus	23-28
32424937-4	2020	Therefore, we silenced STAT3 upstream molecules including the S1PR1 and GP130 molecules in cancer cells using small interfering RNA (siRNA)-loaded alginate-conjugated trimethyl chitosan (ATMC) nanoparticles (NPs).	atmc	187-191	signal transducer and activator of transcription 3	Mus musculus	23-28
33127205-0	2020	Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling.	podocarpusflavone A	0-19	signal transducer and activator of transcription 3	Mus musculus	83-88
33127205-4	2020	Podocarpusflavone A (PCFA) was identified as an inhibitor of STAT3, which was further verified in four melanoma cell lines.	podocarpusflavone A	0-19	signal transducer and activator of transcription 3	Mus musculus	61-66
33127205-4	2020	Podocarpusflavone A (PCFA) was identified as an inhibitor of STAT3, which was further verified in four melanoma cell lines.	podocarpusflavone A	21-25	signal transducer and activator of transcription 3	Mus musculus	61-66
33127205-7	2020	PCFA inhibited the activation of STAT3 through suppressing the phosphorylation of JAK2, and then restrained cell cycle and induced apoptosis of melanoma cells.	podocarpusflavone A	0-4	signal transducer and activator of transcription 3	Mus musculus	33-38
33127205-8	2020	CONCLUSION: PCFA inhibits melanoma growth via the inhibition of JAK2/STAT3 pathway, which provides a promising therapeutic strategies of melanoma treatment.	podocarpusflavone A	12-16	signal transducer and activator of transcription 3	Mus musculus	69-74
33292347-0	2020	Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice.	Catechin	0-9	signal transducer and activator of transcription 3	Mus musculus	64-69
33292347-12	2020	Further, catechins significantly reduced the expression of p-STAT3 and increased the expression of p-IRS1 and p-PI3K in the uterus of PCOS mice.	Catechin	9-18	signal transducer and activator of transcription 3	Mus musculus	61-66
33292347-13	2020	CONCLUSION: Catechins from oolong tea can alleviate ovarian dysfunction and insulin resistance in PCOS mice by inhibiting uterine inflammation and matrix degradation via inhibiting p-STAT3 signaling.	Catechin	12-21	signal transducer and activator of transcription 3	Mus musculus	183-188
33294147-8	2020	Left ventricular hypertrophy and cardiac dysfunction were improved significantly, phosphorylated STAT3 and TLR4 were alleviated, and macrophage infiltration in the myocardium was inhibited after administration of empagliflozin in CORT-treated mice.	empagliflozin	213-226	signal transducer and activator of transcription 3	Mus musculus	97-102
32828944-12	2020	SIGNIFICANCE: Raloxifene has effects on inhibiting atherosclerosis development, the underlying mechanisms might involve in inhibiting inflammation-related IL-6/STAT3 signaling pathway.	Raloxifene Hydrochloride	14-24	signal transducer and activator of transcription 3	Mus musculus	160-165
33216475-9	2020	The expression of COX-2, 5-LO, NF-kappaB and STAT3 in lung tissue was significantly reduced after treatment with LINS01007.	lins01007	113-122	signal transducer and activator of transcription 3	Mus musculus	45-50
32896600-6	2020	KVN93 altered neuroinflammation induced by LPS in microglial cells but not primary astrocytes by regulating TLR4/AKT/STAT3 signaling, and in wild-type mice injected with LPS, KVN93 treatment reduced microglial and astrocyte activation.	kvn93	0-5	signal transducer and activator of transcription 3	Mus musculus	117-122
33212804-0	2020	Small-Dose Sunitinib Modulates p53, Bcl-2, STAT3, and ERK1/2 Pathways and Protects against Adenine-Induced Nephrotoxicity.	Sunitinib	11-20	signal transducer and activator of transcription 3	Mus musculus	43-48
33212804-10	2020	Furthermore, sunitinib decreased (p < 0.5) renal levels of TGF-beta1, p-ERK1/2, and phospho-STAT3 while elevating Bcl-2 expression score.	Sunitinib	13-22	signal transducer and activator of transcription 3	Mus musculus	92-97
32828944-0	2020	Raloxifene inhibits IL-6/STAT3 signaling pathway and protects against high-fat-induced atherosclerosis in ApoE-/- mice.	Raloxifene Hydrochloride	0-10	signal transducer and activator of transcription 3	Mus musculus	25-30
32828944-2	2020	Our previous studies found that Raloxifene targeted against IL-6/GP130 protein-protein interface and inhibited STAT3 phosphorylation induced by IL-6 in cancer cells.	Raloxifene Hydrochloride	32-42	signal transducer and activator of transcription 3	Mus musculus	111-116
32828944-3	2020	However, whether Raloxifene could suppress IL-6/STAT3 signaling pathway and attenuate atherosclerosis in high-fat diet (HFD)-induced mice remains unknown.	Raloxifene Hydrochloride	17-27	signal transducer and activator of transcription 3	Mus musculus	48-53
32828944-9	2020	Histological analysis showed that the expression of IL-6, P-STAT3, ICAM-1, VCAM-1, CD68 and alpha-SMA were significantly decreased in the Raloxifene intervention group compared to HFD group.	Raloxifene Hydrochloride	138-148	signal transducer and activator of transcription 3	Mus musculus	60-65
33442382-0	2020	Paeonol Suppresses Proliferation and Motility of Non-Small-Cell Lung Cancer Cells by Disrupting STAT3/NF-kappaB Signaling.	paeonol	0-7	signal transducer and activator of transcription 3	Mus musculus	96-101
33746736-13	2020	WCAF treatment decreased the mRNA expression of Leptin and VEGF-A, while the protein levels of CD31, LEP-R, VEGFR-1, STAT3, and p-STAT3 were decreased in tumor tissues.	wcaf	0-4	signal transducer and activator of transcription 3	Mus musculus	117-122
33746736-13	2020	WCAF treatment decreased the mRNA expression of Leptin and VEGF-A, while the protein levels of CD31, LEP-R, VEGFR-1, STAT3, and p-STAT3 were decreased in tumor tissues.	wcaf	0-4	signal transducer and activator of transcription 3	Mus musculus	130-135
33442382-14	2020	In addition, paeonol inhibited the transcriptional activity of nuclear factor-kappaB (NF-kappaB) and phosphorylation of signal transducers and activators of transcription 3 (STAT3).	paeonol	13-20	signal transducer and activator of transcription 3	Mus musculus	120-172
33442382-14	2020	In addition, paeonol inhibited the transcriptional activity of nuclear factor-kappaB (NF-kappaB) and phosphorylation of signal transducers and activators of transcription 3 (STAT3).	paeonol	13-20	signal transducer and activator of transcription 3	Mus musculus	174-179
33442382-16	2020	Conclusion: Paeonol potently inhibited NSCLC cell growth, migration and invasion associated with disruption of STAT3 and NF-kappaB pathways, suggesting that it could be a promising anti-metastatic candidate for tumor chemotherapy.	paeonol	12-19	signal transducer and activator of transcription 3	Mus musculus	111-116
33182770-6	2020	Interestingly, PA decreased the levels of proteins associated with anoikis resistance, including p21, cyclin D1, p-STAT3, and HO-1.	Protactinium	15-17	signal transducer and activator of transcription 3	Mus musculus	115-120
33182770-7	2020	Ectopic expression of active STAT3 attenuated PA-induced anoikis sensitivity.	Protactinium	46-48	signal transducer and activator of transcription 3	Mus musculus	29-34
32814243-10	2020	Inhibition of FKN/CX3CR1-activated Jak2/Stat3 signaling by the Jak/Stat inhibitor AG490 blocked osteogenic transformation of VSMCs and RUNX2 induction concurrently.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	82-87	signal transducer and activator of transcription 3	Mus musculus	40-45
33156836-9	2020	Th17 cell and phosphorylated STAT3-expressed cell populations were also decreased in LGNP-CoQ10 injected mice.	coenzyme Q10	90-95	signal transducer and activator of transcription 3	Mus musculus	29-34
33313269-0	2020	Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1alpha axis and STAT3 signaling.	Aspirin	0-7	signal transducer and activator of transcription 3	Mus musculus	99-104
33313269-14	2020	Moreover, aspirin reduced the levels of inflammatory factors interleukin-6, interleukin-1beta and tumor necrosis factor-alpha and decreased the activation of STAT3 signaling pathway.	Aspirin	10-17	signal transducer and activator of transcription 3	Mus musculus	158-163
33313269-15	2020	Conclusions: This is the first study to find that aspirin can alleviate denervation-induced muscle atrophy and inhibit the type I-to-type II muscle fiber conversion and mitophagy possibly through regulating the STAT3 inflammatory signaling pathway and Sirt1/PGC-1alpha signal axis.	Aspirin	50-57	signal transducer and activator of transcription 3	Mus musculus	211-216
32621886-0	2020	Interleukin-9 Aggravates Isoproterenol-Induced Heart Failure by Activating Signal Transducer and Activator of Transcription 3 Signalling.	Isoproterenol	25-38	signal transducer and activator of transcription 3	Mus musculus	75-125
32621886-10	2020	IL-9 did not activate signal transducer and activator of transcription (STAT)1 or STAT5 but induced STAT3 phosphorylation in ISO-induced HF.	Isoproterenol	125-128	signal transducer and activator of transcription 3	Mus musculus	100-105
32621886-11	2020	Moreover, S31-201, a specific STAT3 inhibitor, nearly abolished rIL-9-induced increases in cardiac dysfunction, hypertrophy, and fibrosis in response to ISO stimulation.	NSC 74859	10-17	signal transducer and activator of transcription 3	Mus musculus	30-35
32621886-11	2020	Moreover, S31-201, a specific STAT3 inhibitor, nearly abolished rIL-9-induced increases in cardiac dysfunction, hypertrophy, and fibrosis in response to ISO stimulation.	Isoproterenol	153-156	signal transducer and activator of transcription 3	Mus musculus	30-35
32621886-12	2020	CONCLUSIONS: IL-9 aggravated cardiac dysfunction and amplified cardiac hypertrophy and fibrosis in the ISO-induced HF model by activating STAT3 signalling.	Isoproterenol	103-106	signal transducer and activator of transcription 3	Mus musculus	138-143
32822805-9	2020	In addition, the stearic acid treated group had lower protein levels of p-JAK2 and p-STAT3 in the VTA and a higher dopamine concentration in the NAc than the oleic acid-treated group.	stearic acid	17-29	signal transducer and activator of transcription 3	Mus musculus	85-90
31738412-0	2020	STAT3-miR-17/20 Signaling Axis Plays a Critical Role in Attenuating Myocardial Infarction following Rapamycin Treatment in Diabetic mice.	Sirolimus	100-109	signal transducer and activator of transcription 3	Mus musculus	0-5
31738412-9	2020	RAPA increased STAT3 phosphorylation and miRNA-17/20a expression in diabetic hearts.	Sirolimus	0-4	signal transducer and activator of transcription 3	Mus musculus	15-20
31738412-13	2020	The post-I/R restoration of phosphorylation of STAT3 and AKT with RAPA were also abolished in miRNA-17-92-deficient diabetic mice.	Sirolimus	66-70	signal transducer and activator of transcription 3	Mus musculus	47-52
31738412-15	2020	CONCLUSION: Induction of STAT3-miRNA-17-92 signaling axis plays a critical role in attenuating myocardial infarction in RAPA-treated diabetic mice.	Sirolimus	120-124	signal transducer and activator of transcription 3	Mus musculus	25-30
31738412-19	2020	Specifically, the results show an essential role of a highly innovative STAT3-miR-17-92-mTOR signaling axis in cardioprotection in diabetes, which may have potential clinical relevance in preventing I/R injury in diabetics because RAPA has relatively mild side effects at low dose.	Sirolimus	231-235	signal transducer and activator of transcription 3	Mus musculus	72-77
33064977-0	2020	LncRNA TSLNC8 synergizes with EGFR inhibitor osimertinib to inhibit lung cancer tumorigenesis by blocking the EGFR-STAT3 pathway.	osimertinib	45-56	signal transducer and activator of transcription 3	Mus musculus	115-120
33202749-0	2020	Plant Volatile, Phenylacetaldehyde Targets Breast Cancer Stem Cell by Induction of ROS and Regulation of Stat3 Signal.	phenylacetaldehyde	16-34	signal transducer and activator of transcription 3	Mus musculus	105-110
33202749-9	2020	Our results suggest that the PAA-induced ROS deregulated Stat3/IL-6 pathway and PAA may be a potential agent targeting breast cancer and CSCs.	Reactive Oxygen Species	41-44	signal transducer and activator of transcription 3	Mus musculus	57-62
32822909-0	2020	Kupffer cell depletion attenuates IL-6/STAT3 mediates hepatocyte apoptosis in immunological liver injury of trichloroethylene sensitized mice.	Trichloroethylene	108-125	signal transducer and activator of transcription 3	Mus musculus	39-44
32822909-6	2020	This study explored the function of IL-6/STAT3 signal pathway on the TCE induced apoptosis of liver cell.	Trichloroethylene	69-72	signal transducer and activator of transcription 3	Mus musculus	41-46
32822909-9	2020	All in all, the activation of KCs can increase the expression of IL-6, IL-6R and phosphorylate STAT3, induces hepatocyte apoptosis, and participates in immunity damage of liver which induced by TCE.	Trichloroethylene	194-197	signal transducer and activator of transcription 3	Mus musculus	95-100
32853927-11	2020	CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management.	th17	70-74	signal transducer and activator of transcription 3	Mus musculus	168-173
32853927-11	2020	CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management.	treg	75-79	signal transducer and activator of transcription 3	Mus musculus	168-173
32064985-4	2020	In this study, we sought to test the hypothesis that oxidative stress injury in ischemic brains and H2O2-treated mouse neuroblastoma Neuro-2a cells (N2a) was related to STAT3 activation.	Water	100-104	signal transducer and activator of transcription 3	Mus musculus	169-174
32818511-0	2020	Ruxolitinib attenuates intimal hyperplasia via inhibiting JAK2/STAT3 signaling pathway activation induced by PDGF-BB in vascular smooth muscle cells.	ruxolitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	63-68
32818511-3	2020	Ruxolitinib, a potent Janus kinase (JAK) 1 and 2 inhibitor, has been reported to significantly block the proliferation-related signaling pathway of JAK2/signal transducers and activators of transcription 3 (STAT3) and harbor a broad spectrum of anti-cancer activities, including proliferation inhibition, apoptosis induction, and anti-inflammation.	ruxolitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	207-212
32818511-10	2020	The JAK2/STAT3 signaling pathway involved in the effects of ruxolitinib on VSMCs was detected by western blotting with the specific pathway inhibitor AG490.	ruxolitinib	60-71	signal transducer and activator of transcription 3	Mus musculus	9-14
32818511-10	2020	The JAK2/STAT3 signaling pathway involved in the effects of ruxolitinib on VSMCs was detected by western blotting with the specific pathway inhibitor AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	150-155	signal transducer and activator of transcription 3	Mus musculus	9-14
32818511-13	2020	In addition, ruxolitinib inhibited the PDGF-BB-induced activation of the JAK2/STAT3 signaling pathway and decreased the expression of proliferation related-proteins cyclinD1 and PCNA in VSMCs (p < 0.05).	ruxolitinib	13-24	signal transducer and activator of transcription 3	Mus musculus	78-83
32818511-14	2020	CONCLUSION: Our findings suggest that ruxolitinib inhibits VSMC proliferation in vivo and in vitro by suppressing the activation of the JAK2/STAT3 signaling pathway.	ruxolitinib	38-49	signal transducer and activator of transcription 3	Mus musculus	141-146
33210595-6	2020	Results After I/R injury in mice, CPU0213 treatment reduced myocardial infarction area, LDH, CK activity and apoptosis rate, but increased the phosphorylation level of JAK2 and STAT3.	CPU0213	34-41	signal transducer and activator of transcription 3	Mus musculus	177-182
33115476-16	2020	This subsequently upregulated SOCS1 and SOCS3 expression and then inhibited the TLR4-NFkappaB and JAK2-STAT3 pathways in hemin-stimulated astrocytes.	Hemin	121-126	signal transducer and activator of transcription 3	Mus musculus	103-108
33091036-6	2020	Mechanistic investigations suggested that these inhibitory effects of Rg3 on MDSCs and corresponding cancer progression depend upon suppression of the STAT3-dependent pathway, tumor-derived cytokines, and the NOTCH signaling pathway.	ginsenoside Rg3	70-73	signal transducer and activator of transcription 3	Mus musculus	151-156
33001081-0	2020	Matcha green tea prevents obesity-induced hypothalamic inflammation via suppressing the JAK2/STAT3 signaling pathway.	matcha green tea	0-16	signal transducer and activator of transcription 3	Mus musculus	93-98
33001081-8	2020	The results showed that matcha ethanol extracts could significantly reduce the release of inflammatory cytokines and the expression and phosphorylation of JAK2 and STAT3.	Ethanol	31-38	signal transducer and activator of transcription 3	Mus musculus	164-169
32975280-7	2020	Furthermore, the inhibitory effect of FA on STAT3 was counteracted by the treatment of miR-124 inhibitor.	mir-124	87-94	signal transducer and activator of transcription 3	Mus musculus	44-49
33046834-5	2021	Mice lacking serotonergic STAT3 presented with reduced negative behavioural reactivity and a blunted response to the sensitising effects of amphetamine, alongside alterations in midbrain neuronal firing activity of serotonergic neurons and transcriptional control of gene networks relevant for neuropsychiatric disorders.	Amphetamine	140-151	signal transducer and activator of transcription 3	Mus musculus	26-31
32659249-5	2020	Our findings show that pharmacological inhibition of Stat3 with WP1066 effectively delays progression and invasiveness of bladder cancer in N-butyl-N-(4-hydroxybutyl) nitrosamine-induced mouse model.	Butylhydroxybutylnitrosamine	140-178	signal transducer and activator of transcription 3	Mus musculus	53-58
32505837-0	2020	Cryptotanshinone prevents muscle wasting in CT26-induced cancer cachexia through inhibiting STAT3 signaling pathway.	cryptotanshinone	0-16	signal transducer and activator of transcription 3	Mus musculus	92-97
32505837-11	2020	We showed that cryptotanshinone significantly suppressed the hyper-activated STAT3 in cachectic muscles and C2C12 myotubes and inhibited STAT3 transcriptional activity, but it did not repress the activation of STAT1.	cryptotanshinone	15-31	signal transducer and activator of transcription 3	Mus musculus	77-82
32505837-11	2020	We showed that cryptotanshinone significantly suppressed the hyper-activated STAT3 in cachectic muscles and C2C12 myotubes and inhibited STAT3 transcriptional activity, but it did not repress the activation of STAT1.	cryptotanshinone	15-31	signal transducer and activator of transcription 3	Mus musculus	137-142
32505837-12	2020	The inhibitory effect of cryptotanshinone on TCM-induced myotube atrophy was blocked by STAT3 overexpression.	cryptotanshinone	25-41	signal transducer and activator of transcription 3	Mus musculus	88-93
32505837-12	2020	The inhibitory effect of cryptotanshinone on TCM-induced myotube atrophy was blocked by STAT3 overexpression.	tcm	45-48	signal transducer and activator of transcription 3	Mus musculus	88-93
32505837-13	2020	CONCLUSIONS: These data suggest that cryptotanshinone prevents muscle wasting in cancer cachexia through STAT3 inhibition, and it may be a promising candidate drug for the treatment of cancer cachexia.	cryptotanshinone	37-53	signal transducer and activator of transcription 3	Mus musculus	105-110
33082817-13	2020	In the CAC model, FLCWK synergized with 5-FU to inhibit the phosphorylation of STAT3, preventing IL-6/STAT3 signal transduction and thus further inducing apoptosis and inhibition of colon cancer cell proliferation.	Fluorouracil	40-44	signal transducer and activator of transcription 3	Mus musculus	79-84
33082817-13	2020	In the CAC model, FLCWK synergized with 5-FU to inhibit the phosphorylation of STAT3, preventing IL-6/STAT3 signal transduction and thus further inducing apoptosis and inhibition of colon cancer cell proliferation.	Fluorouracil	40-44	signal transducer and activator of transcription 3	Mus musculus	102-107
33082817-14	2020	Conclusion: FLCWK can inhibit the activation of STAT3 by reducing the production of IL-6, thereby increasing the occurrence of colitis-related colorectal cancer with 5-FU.	Fluorouracil	166-170	signal transducer and activator of transcription 3	Mus musculus	48-53
33064977-12	2020	In this study, we revealed a TSLNC8-EGFR-STAT3 signaling axis in lung cancer, and TSLNC8 overexpression significantly enhanced the anti-tumor effects of osimertinib via inhibiting EGFR-STAT3 signaling.	osimertinib	153-164	signal transducer and activator of transcription 3	Mus musculus	41-46
33064977-12	2020	In this study, we revealed a TSLNC8-EGFR-STAT3 signaling axis in lung cancer, and TSLNC8 overexpression significantly enhanced the anti-tumor effects of osimertinib via inhibiting EGFR-STAT3 signaling.	osimertinib	153-164	signal transducer and activator of transcription 3	Mus musculus	185-190
33047939-3	2020	In this study, we demonstrated that eradication of STAT3 signaling by the inhibitors cryptotanshinone (CPT, a STAT3-specific inhibitor) or STAT3 siRNA both suppressed osteogenic differentiation of MC3T3-E1 cells, with a decrease in alkaline phosphatase (ALP) activity, protein expressions of the osteogenic differentiation markers Collagen I (ColI), ALP, and osteocalcin (OCN), and reduced matrix mineralization capacity at the terminal stage of osteogenic differentiation.	cryptotanshinone	85-101	signal transducer and activator of transcription 3	Mus musculus	51-56
33047939-3	2020	In this study, we demonstrated that eradication of STAT3 signaling by the inhibitors cryptotanshinone (CPT, a STAT3-specific inhibitor) or STAT3 siRNA both suppressed osteogenic differentiation of MC3T3-E1 cells, with a decrease in alkaline phosphatase (ALP) activity, protein expressions of the osteogenic differentiation markers Collagen I (ColI), ALP, and osteocalcin (OCN), and reduced matrix mineralization capacity at the terminal stage of osteogenic differentiation.	cryptotanshinone	85-101	signal transducer and activator of transcription 3	Mus musculus	110-115
33047939-3	2020	In this study, we demonstrated that eradication of STAT3 signaling by the inhibitors cryptotanshinone (CPT, a STAT3-specific inhibitor) or STAT3 siRNA both suppressed osteogenic differentiation of MC3T3-E1 cells, with a decrease in alkaline phosphatase (ALP) activity, protein expressions of the osteogenic differentiation markers Collagen I (ColI), ALP, and osteocalcin (OCN), and reduced matrix mineralization capacity at the terminal stage of osteogenic differentiation.	cryptotanshinone	85-101	signal transducer and activator of transcription 3	Mus musculus	110-115
32717226-0	2020	Dehydrodieugenol improved lung inflammation in an asthma model by inhibiting the STAT3/SOCS3 and MAPK pathways.	dehydrodieugenol	0-16	signal transducer and activator of transcription 3	Mus musculus	81-86
32816860-6	2020	Conversely, copper chelators inhibited phosphorylation of STAT3 and EGFR and promoted ubiquitin-mediated degradation of PD-L1.	Copper	12-18	signal transducer and activator of transcription 3	Mus musculus	58-63
33210595-8	2020	After oxidative stress damage to cardiomyocytes, CPU0213 treatment reduced LDH, CK activity and cell apoptosis rate, and increased the phosphorylation level of JAK2 and STAT3.	CPU0213	49-56	signal transducer and activator of transcription 3	Mus musculus	169-174
33210595-10	2020	Conclusion The activation of JAK2/STAT3 pathway by CPU0213 can inhibit the apoptosis of cardiomyocytes induced by I/R and oxidative stress.	CPU0213	51-58	signal transducer and activator of transcription 3	Mus musculus	34-39
32780898-7	2020	High-uric acid levels-induced p-STAT3 inhibition and SREBP-1c activation in vivo and in vitro.	Uric Acid	5-14	signal transducer and activator of transcription 3	Mus musculus	32-37
32815642-6	2020	In addition, enhanced expression of miR-124-3p attenuated apoptosis and ROS production by targeting regulation of STAT3 in LPS-induced colonic cells.	Reactive Oxygen Species	72-75	signal transducer and activator of transcription 3	Mus musculus	114-119
32750435-0	2020	Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.	polydatin	0-9	signal transducer and activator of transcription 3	Mus musculus	104-109
32747421-7	2020	PBT treatment blunted M2-like alternative activation of bone marrow-derived macrophages and reduced STAT3 activation in MDSC cultures while increasing the differentiation of CD80+, CD11c+ macrophages.	(E)-2-(pent-3-en-1-yn-1-yl)thiophene	0-3	signal transducer and activator of transcription 3	Mus musculus	100-105
32813574-5	2020	After acute exposure to NiNPs and LPS, male mice had elevated cytokines (CXCL1 and IL-6) and more neutrophils in bronchoalveolar lavage fluid (BALF), along with greater STAT3 phosphorylation in lung tissue.	ninps	24-29	signal transducer and activator of transcription 3	Mus musculus	169-174
32653534-0	2020	Xanthatin alleviates airway inflammation in asthmatic mice by regulating the STAT3/NF-kappaB signaling pathway.	xanthatin	0-9	signal transducer and activator of transcription 3	Mus musculus	77-82
32653534-3	2020	Our results showed that OVA injection significantly increased inflammatory cell infiltration and goblet cell hyperplasia in lung issues, while Xanthatin treatment and STAT3 inhibitor C188-9 administration relieved these symptoms.	C188-9	183-189	signal transducer and activator of transcription 3	Mus musculus	167-172
32653534-6	2020	We further demonstrated that the STAT3/NF-kappaB pathway was blocked by Xanthatin in asthmatic mice.	xanthatin	72-81	signal transducer and activator of transcription 3	Mus musculus	33-38
32653534-7	2020	Overall, we conclude that Xanthatin attenuates airway inflammation in asthmatic mice through blocking the STAT3/NFkappaB signaling pathway, indicating the potential of Xanthatin as a useful therapeutic agent for asthma.	xanthatin	26-35	signal transducer and activator of transcription 3	Mus musculus	106-111
32653534-7	2020	Overall, we conclude that Xanthatin attenuates airway inflammation in asthmatic mice through blocking the STAT3/NFkappaB signaling pathway, indicating the potential of Xanthatin as a useful therapeutic agent for asthma.	xanthatin	168-177	signal transducer and activator of transcription 3	Mus musculus	106-111
33004854-9	2020	Our data further indicate that STAT3 pathway modulates interactions between B and T cells during EAU resulting in alteration of lymphocyte repertoire by increasing levels of autoreactive pathogenic T cells while suppressing development and/or expansion of immune-suppressive lymphocytes (Bregs and Tregs).	Water	97-100	signal transducer and activator of transcription 3	Mus musculus	31-36
32999332-3	2020	Treatment of mice on a HFD with Quizartinib, a potent inhibitor of FLT3 phosphorylation, inhibits the JAK3/STAT3, signaling and finally antagonizes the accelerated development of AML that occurred following the HFD regimen.	quizartinib	32-43	signal transducer and activator of transcription 3	Mus musculus	107-112
33101013-11	2020	These results revealed that CSO exerted an anti-TNBC effect via the miR-205/S1PR1 axis to regulate sphingomyelin metabolism, and the downstream STAT3/MAPK/AKT signal pathways were partly involved.	CSO	28-31	signal transducer and activator of transcription 3	Mus musculus	144-149
32973326-0	2021	Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling.	sodium propionate	0-17	signal transducer and activator of transcription 3	Mus musculus	107-112
32973326-0	2021	Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling.	ros	113-116	signal transducer and activator of transcription 3	Mus musculus	107-112
33205009-4	2020	Oxazolone pervasively upregulates Jak2/Stat3 expression across T cells and antigen-presenting cells (APCs).	Oxazolone	0-9	signal transducer and activator of transcription 3	Mus musculus	39-44
32982449-19	2020	Conclusion: These data suggested that miR-125b inhibited invasion and metastasis in gastric cancer by inhibiting STAT3; therefore, miR-125b and STAT3 could be potential therapeutic targets in the treatment of gastric cancer.	mir-125b	38-46	signal transducer and activator of transcription 3	Mus musculus	113-118
32982449-19	2020	Conclusion: These data suggested that miR-125b inhibited invasion and metastasis in gastric cancer by inhibiting STAT3; therefore, miR-125b and STAT3 could be potential therapeutic targets in the treatment of gastric cancer.	mir-125b	38-46	signal transducer and activator of transcription 3	Mus musculus	144-149
32982449-19	2020	Conclusion: These data suggested that miR-125b inhibited invasion and metastasis in gastric cancer by inhibiting STAT3; therefore, miR-125b and STAT3 could be potential therapeutic targets in the treatment of gastric cancer.	mir-125b	131-139	signal transducer and activator of transcription 3	Mus musculus	113-118
32605912-3	2020	METHODS: C57BL/6 mice underwent intracerebral implantation of GL261 glioma cells, WBRT, and treatment with WP1066, a blood-brain barrier (BBB)-penetrant inhibitor of the STAT3 pathway, or the two in combination.	WP1066	107-113	signal transducer and activator of transcription 3	Mus musculus	170-175
32646922-11	2020	In both humans and mice, metformin triggered AMPK activation and STAT3 inactivation, and altered the production of effector cytokines (i.e. TNF-alpha, IFN-gamma, IL-10) in the immune cells.	Metformin	25-34	signal transducer and activator of transcription 3	Mus musculus	65-70
32937997-4	2020	In mice brain cortices, ethanol treatment lowers mir-146a-5p and mir-21-5p levels, while triggering a higher expression of inflammatory target genes (Traf6, Stat3, and Camk2a) in adolescent female mice.	Ethanol	24-31	signal transducer and activator of transcription 3	Mus musculus	157-162
32655003-3	2020	A circular oligonucleotide STAT3 decoy (CS3D) was used to treat mice previously exposed to the tobacco carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	Oligonucleotides	11-26	signal transducer and activator of transcription 3	Mus musculus	27-32
33042284-0	2020	Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKalpha/STAT3 signaling in diet-induced obesity.	Saponins	18-26	signal transducer and activator of transcription 3	Mus musculus	145-150
32768939-7	2020	LBZ activates PI3K/Akt signaling pathways and granulocyte-colony-stimulating-factor (G-CSF)-mediated Janus kinase 2 (JAK2)/transcription 3 (STAT3), resulting in inhibiting the release of cytochrome c. Further, LBZ inhibits caspase-mediated mitochondrial-dependent apoptosis mediated by caspase-9 and caspase-3.	lbz	0-3	signal transducer and activator of transcription 3	Mus musculus	140-145
32768939-7	2020	LBZ activates PI3K/Akt signaling pathways and granulocyte-colony-stimulating-factor (G-CSF)-mediated Janus kinase 2 (JAK2)/transcription 3 (STAT3), resulting in inhibiting the release of cytochrome c. Further, LBZ inhibits caspase-mediated mitochondrial-dependent apoptosis mediated by caspase-9 and caspase-3.	lbz	210-213	signal transducer and activator of transcription 3	Mus musculus	140-145
32768939-8	2020	LBZ can thus reduce CTX-induced HD via G-CSF-mediated JAK2/STAT3 signaling and PI3K/Akt mitochondrial-dependent apoptotic pathways.	lbz	0-3	signal transducer and activator of transcription 3	Mus musculus	59-64
32768945-0	2020	Astilbin combined with lipopolysaccharide induces IL-10-producing regulatory B cells via the STAT3 signalling pathway.	astilbin	0-8	signal transducer and activator of transcription 3	Mus musculus	93-98
32943679-3	2020	We investigated whether in vivo introduction of synthetic double-stranded STAT3 decoy oligodeoxynucleotides (ODNs) can provide benefits for reducing organ injury and mortality in mice with cecal ligation and puncture (CLP)-induced polymicrobial sepsis.	decoy oligodeoxynucleotides	80-107	signal transducer and activator of transcription 3	Mus musculus	74-79
32943679-7	2020	Finally, STAT3 decoy ODN administration minimized the development of sepsis-driven major end-organ injury and led to a significant survival advantage in mice after CLP.	Oligodeoxyribonucleotides	21-24	signal transducer and activator of transcription 3	Mus musculus	9-14
32821888-9	2020	The STAT3 inhibitor NSC 74859 was especially effective in further reducing the cell survival rates, suggesting its possible exploitation for therapeutic gain.	NSC 74859	20-29	signal transducer and activator of transcription 3	Mus musculus	4-9
32848054-0	2020	Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation.	o-glcnac	37-45	signal transducer and activator of transcription 3	Mus musculus	83-88
32848054-7	2020	Moreover, using O-GlcNAc-specific mass spectrometry analysis of the aging hippocampus, together with an in vitro site-directed mutagenesis approach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of astrocyte differentiation.	o-glcnac	16-24	signal transducer and activator of transcription 3	Mus musculus	169-174
32848054-7	2020	Moreover, using O-GlcNAc-specific mass spectrometry analysis of the aging hippocampus, together with an in vitro site-directed mutagenesis approach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of astrocyte differentiation.	o-glcnac	175-183	signal transducer and activator of transcription 3	Mus musculus	169-174
32848054-7	2020	Moreover, using O-GlcNAc-specific mass spectrometry analysis of the aging hippocampus, together with an in vitro site-directed mutagenesis approach, we identify loss of STAT3 O-GlcNAc at Threonine 717 as a driver of astrocyte differentiation.	Threonine	187-196	signal transducer and activator of transcription 3	Mus musculus	169-174
32619677-9	2020	Additionally, we showed that PNU-282987 inhibited STAT3-phosphorylation and reduced SOCS3 expression in the lung.	PNU-282987	29-39	signal transducer and activator of transcription 3	Mus musculus	50-55
32655003-3	2020	A circular oligonucleotide STAT3 decoy (CS3D) was used to treat mice previously exposed to the tobacco carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).	SCHEMBL420028	114-172	signal transducer and activator of transcription 3	Mus musculus	27-32
32859456-0	2020	Dihydroartemisinin inhibits melanoma by regulating CTL/Treg anti-tumor immunity and STAT3-mediated apoptosis via IL-10 dependent manner.	artenimol	0-18	signal transducer and activator of transcription 3	Mus musculus	84-89
32768945-11	2020	Combined astilbin and LPS stimulated the STAT3 activation of CD19+ TIM-1+ cells but had no effects on SOCS3, AKT, NF-kappaB, Erk, JNK nor P38.	astilbin	9-17	signal transducer and activator of transcription 3	Mus musculus	41-46
32768945-12	2020	Inhibiting the STAT3 phosphorylation of CD19+ TIM-1+ cells abolished Breg induction by astilbin/LPS.	astilbin	87-95	signal transducer and activator of transcription 3	Mus musculus	15-20
32363523-10	2020	The mechanism of THH in the treatment of CIA may be through the inhibition of the NF-kB-STAT3-IL-17 pathway, which also requires further experimental investigation.	5-methyltetrahydrofolate	17-20	signal transducer and activator of transcription 3	Mus musculus	88-93
32656894-4	2020	In the bleomycin (BLM) model of lung fibrosis, CKO mice had reduced fibrosis, lesser fibroblast ERK activation, and diminished immune cell STAT3 phosphorylation.	Bleomycin	18-21	signal transducer and activator of transcription 3	Mus musculus	139-144
32859456-12	2020	Moreover, DHA administration significantly promoted the mitochondrial apoptosis of melanoma by regulating the STAT3 pathway.	artenimol	10-13	signal transducer and activator of transcription 3	Mus musculus	110-115
32859456-13	2020	CONCLUSION: DHA induces mitochondrial apoptosis and alters cytokines expression by inhibiting the phosphorylation of STAT3.	artenimol	12-15	signal transducer and activator of transcription 3	Mus musculus	117-122
32934775-3	2020	We demonstrate that the administration of BAY 11-7082, either before or after acidic bile, eliminates NF-kappaB activation, prevents overexpression of Bcl2, Rela, Stat3, Egfr, Tnf, Wnt5a, and deregulations of miR-192, miR-504, linked to bile reflux-related hypopharyngeal cancer.	3-(4-methylphenylsulfonyl)-2-propenenitrile	42-53	signal transducer and activator of transcription 3	Mus musculus	163-168
31967324-7	2020	Mechanistically, the level of phosphorylated STAT3 was elevated in unpolarized and restorative macrophages after treatment with fucoidan.	fucoidan	128-136	signal transducer and activator of transcription 3	Mus musculus	45-50
31967324-8	2020	Taken together, our findings suggest that fucoidan treatment inhibits OTM and enhances the stability of teeth after movement by promoting restorative macrophages through the STAT3 pathway.	fucoidan	42-50	signal transducer and activator of transcription 3	Mus musculus	174-179
32319222-6	2020	MC3T3-E1 cells in both miR-135b mimics and AG490 groups manifested decrease in cell viability, ALP activity, and mineralized nodes, as well as reductions in osteoblast-specific genes and proteins of JAK2, p-JAK2, and p-STAT3, but increase in cell apoptosis.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	43-48	signal transducer and activator of transcription 3	Mus musculus	219-224
32872335-5	2020	In addition, tranylcypromine modulated LPS-mediated TLR4/ERK/STAT3 signaling to alter neuroinflammatory responses in BV2 microglial cells.	Tranylcypromine	13-28	signal transducer and activator of transcription 3	Mus musculus	61-66
32954049-7	2021	The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod (IMQ) in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.	Imiquimod	122-131	signal transducer and activator of transcription 3	Mus musculus	185-190
32582968-0	2020	Lapatinib-induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro.	Lapatinib	0-9	signal transducer and activator of transcription 3	Mus musculus	72-77
32582968-9	2020	This lack of effect of lapatinib on ovarian function may be due to the activation of the STAT3 signaling pathway that counteracts the inhibitory effects of lapatinib on EGF receptors.	Lapatinib	156-165	signal transducer and activator of transcription 3	Mus musculus	89-94
32954049-7	2021	The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod (IMQ) in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.	Imiquimod	133-136	signal transducer and activator of transcription 3	Mus musculus	185-190
32829707-14	2020	CONCLUSIONS: Ceramide could up-regulate MMP-9 expression through the activation of the JAK2/STAT3 pathway in airway epithelium.	Ceramides	13-21	signal transducer and activator of transcription 3	Mus musculus	92-97
32875209-8	2020	The lactoferrin + linolenic acid combination inhibited phosphorylation in the JAK2/STAT3-related pathway by downregulating the special metabolite lithocholyltaurine, thereby suppressing formation of KYSE450 tumors.	alpha-Linolenic Acid	18-32	signal transducer and activator of transcription 3	Mus musculus	83-88
32904640-9	2020	Additionally, Huaier extract treatment led to reduced pro-inflammatory cytokine levels (TNF-alpha, IL-6, IFN-gamma and IL-1beta) and a decrease of STAT3 phosphorylation in colon tissue.	extract	21-28	signal transducer and activator of transcription 3	Mus musculus	147-152
32875209-0	2020	The Combination of Two Bioactive Constituents, Lactoferrin and Linolenic Acid, Inhibits Mouse Xenograft Esophageal Tumor Growth by Downregulating Lithocholyltaurine and Inhibiting the JAK2/STAT3-Related Pathway.	alpha-Linolenic Acid	63-77	signal transducer and activator of transcription 3	Mus musculus	189-194
32762699-0	2020	TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway.	Dextran Sulfate	20-23	signal transducer and activator of transcription 3	Mus musculus	86-91
32762699-4	2020	TAK-242 markedly alleviated DSS-induced colitis symptoms and colonic lesions by promoting IL-10 release, inhibiting IL-17 release, downregulating TLR4 and JAK2/STAT3 mRNA and protein expression and increasing JAK2/STAT3 phosphorylation.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	signal transducer and activator of transcription 3	Mus musculus	160-165
32762699-4	2020	TAK-242 markedly alleviated DSS-induced colitis symptoms and colonic lesions by promoting IL-10 release, inhibiting IL-17 release, downregulating TLR4 and JAK2/STAT3 mRNA and protein expression and increasing JAK2/STAT3 phosphorylation.	ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate	0-7	signal transducer and activator of transcription 3	Mus musculus	214-219
32762699-4	2020	TAK-242 markedly alleviated DSS-induced colitis symptoms and colonic lesions by promoting IL-10 release, inhibiting IL-17 release, downregulating TLR4 and JAK2/STAT3 mRNA and protein expression and increasing JAK2/STAT3 phosphorylation.	Dextran Sulfate	28-31	signal transducer and activator of transcription 3	Mus musculus	160-165
32762699-4	2020	TAK-242 markedly alleviated DSS-induced colitis symptoms and colonic lesions by promoting IL-10 release, inhibiting IL-17 release, downregulating TLR4 and JAK2/STAT3 mRNA and protein expression and increasing JAK2/STAT3 phosphorylation.	Dextran Sulfate	28-31	signal transducer and activator of transcription 3	Mus musculus	214-219
32759670-6	2020	We further show that PKCdelta knockdown and mito-apocynin, a mitochondrial antioxidant, suppress TWEAK-induced proinflammatory NLRC4/STAT3 signaling and cellular oxidative stress response.	mito-apocynin	44-57	signal transducer and activator of transcription 3	Mus musculus	133-138
32780864-2	2020	Our previous work showed that CNTF-induced STAT3 signaling is a potent inhibitor of pathologic preretinal neovascular tuft formation in the mouse model of oxygen-induced retinopathy.	Oxygen	155-161	signal transducer and activator of transcription 3	Mus musculus	43-48
32905416-13	2020	Finally, mouse xenograft data indicated that ovatodiolide suppressed tumor growth via down-regulating IL-6, STAT3, beta-catenin expression, and serum exosomal miR-1246.	ovatodiolide	45-57	signal transducer and activator of transcription 3	Mus musculus	108-113
32905416-14	2020	In conclusion, our findings provided preclinical supports for ovatodiolide as a colon CSC inhibitor by reducing beta-catenin/STAT3/miR-1246 signaling conveyed by CSC derived exosomes.	ovatodiolide	62-74	signal transducer and activator of transcription 3	Mus musculus	125-130
32615888-0	2020	Curcumin attenuates inflammation and cell apoptosis through regulating NF-kappaB and JAK2/STAT3 signaling pathway against acute kidney injury.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	90-95
32615888-5	2020	Western blot analysis indicated that Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3, p-65-NF-kappaB and cell apoptosis pathways were activated by LPS but suppressed by Curcumin.	Curcumin	200-208	signal transducer and activator of transcription 3	Mus musculus	58-115
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	prolinedithiocarbamate	10-14	signal transducer and activator of transcription 3	Mus musculus	110-115
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	16-22	signal transducer and activator of transcription 3	Mus musculus	110-115
32615888-7	2020	Moreover, PDTC, AG-490 and Curcumin all significantly reversed the previously increased expressions of p-JAK2/STAT3, p-p65 and proapoptotic proteins in the mice with AKI.	Curcumin	27-35	signal transducer and activator of transcription 3	Mus musculus	110-115
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	95-100
32615888-8	2020	The present study revealed that Curcumin attenuated SAKI through inhibiting NF-kappaB and JAK2/STAT3 signaling pathways, and proposed that Curcumin could be a potential therapeutic agent for treating SAKI.	Curcumin	139-147	signal transducer and activator of transcription 3	Mus musculus	95-100
32790968-11	2020	Berberine activated IL6/STAT3 signaling in in vitro culture of G-MSDCs-like population, while inhibition of STAT3 activity attenuated the activation of this population by berberine.	Berberine	0-9	signal transducer and activator of transcription 3	Mus musculus	24-29
32790968-11	2020	Berberine activated IL6/STAT3 signaling in in vitro culture of G-MSDCs-like population, while inhibition of STAT3 activity attenuated the activation of this population by berberine.	Berberine	171-180	signal transducer and activator of transcription 3	Mus musculus	108-113
32908937-8	2020	In conclusion, GA ameliorated the symptoms of psoriasis, at least in part, through inhibition of inflammatory cytokines and STAT3/mTOR signaling and activation of Tregs in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	15-17	signal transducer and activator of transcription 3	Mus musculus	124-129
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	Sesquiterpenes	12-26	signal transducer and activator of transcription 3	Mus musculus	155-160
32823063-4	2020	Remarkably, sesquiterpenes of the Pelorol family, which we previously described as allosteric activators of SHIP1 phosphatase activity, could induce SHIP1/STAT3 complex formation in cells and mimic the anti-inflammatory action of IL10 in a mouse model of colitis.	pelorol	34-41	signal transducer and activator of transcription 3	Mus musculus	155-160
32875209-8	2020	The lactoferrin + linolenic acid combination inhibited phosphorylation in the JAK2/STAT3-related pathway by downregulating the special metabolite lithocholyltaurine, thereby suppressing formation of KYSE450 tumors.	Taurolithocholic Acid	146-164	signal transducer and activator of transcription 3	Mus musculus	83-88
32511016-0	2020	Sunitinib inhibits PD-L1 expression in osteosarcoma by targeting STAT3 and remodels the immune system in tumor-bearing mice.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	65-70
31802384-13	2020	Furthermore, baicalin inhibited STAT1 and activated STAT3 signaling pathways.	baicalin	13-21	signal transducer and activator of transcription 3	Mus musculus	52-57
32511016-5	2020	Results: Sunitinib reduced the expression of PD-L1 by inhibiting the activation of STAT3 and suppressed the migration and invasion in osteosarcoma cells.	Sunitinib	9-18	signal transducer and activator of transcription 3	Mus musculus	83-88
32511016-7	2020	Conclusion: Sunitinib inhibits PD-L1 expression by targeting STAT3 and remodels the immune system in tumor-bearing mice.	Sunitinib	12-21	signal transducer and activator of transcription 3	Mus musculus	61-66
32521492-7	2020	Moreover, the consistent variation of IL-1beta and phospho-STAT3 expression in brain tissues, indicated a role of STAT3 pathway in IL-1beta production and anti-inflammatory effect of GB.	ginkgolide B	183-185	signal transducer and activator of transcription 3	Mus musculus	59-64
32538204-7	2020	Furthermore, we revealed that RNF38/SHP-1/STAT3 signaling should play a critical role in calycosin-promoted beta cell function, and forced expression of RNF38 attenuated the positive effects of calycosin on beta cells.Conclusion: Our study implied that calycosin exerts favorable effects on GDM mice via rebalancing insulin sensitivity and inflammatory response.	7,3'-dihydroxy-4'-methoxyisoflavone	89-98	signal transducer and activator of transcription 3	Mus musculus	42-47
32544868-0	2020	2"-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway.	2'-fucosyllactose	0-17	signal transducer and activator of transcription 3	Mus musculus	104-109
32544868-0	2020	2"-fucosyllactose inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response via the STAT3 signaling pathway.	Imiquimod	27-36	signal transducer and activator of transcription 3	Mus musculus	104-109
32544868-6	2020	Furthermore, we have demonstrated that 2"-FL reduced the phosphorylation of STAT3 in the skin tissue from mice with IMQ stimulation, which could account for the decreasing recruitment of Th17 cells.	2'-fucosyllactose	39-44	signal transducer and activator of transcription 3	Mus musculus	76-81
32544868-6	2020	Furthermore, we have demonstrated that 2"-FL reduced the phosphorylation of STAT3 in the skin tissue from mice with IMQ stimulation, which could account for the decreasing recruitment of Th17 cells.	Imiquimod	116-119	signal transducer and activator of transcription 3	Mus musculus	76-81
32544868-7	2020	In vitro studies showed that 2"-FL inhibited differentiation of Th17 cells, phosphorylation of STAT3, and RORgammat mRNA levels in T cells under Th17 polarization.	2'-fucosyllactose	29-34	signal transducer and activator of transcription 3	Mus musculus	95-100
32544868-8	2020	Our results indicate that 2"-FL ameliorates IMQ-induced psoriasis by inhibiting Th17 cell immune response and Th17-related cytokine secretion via modulation of the STAT3 signaling pathway.	2'-fucosyllactose	26-31	signal transducer and activator of transcription 3	Mus musculus	164-169
32544868-8	2020	Our results indicate that 2"-FL ameliorates IMQ-induced psoriasis by inhibiting Th17 cell immune response and Th17-related cytokine secretion via modulation of the STAT3 signaling pathway.	Imiquimod	44-47	signal transducer and activator of transcription 3	Mus musculus	164-169
32626920-12	2020	Taken together, these findings demonstrated that intranasal administration of IL-27 ameliorated Th2-related allergic lung inflammation and remodeling in mouse models of asthma by repairing both the STAT1 and STAT3 pathways.	th2	96-99	signal transducer and activator of transcription 3	Mus musculus	208-213
32521492-7	2020	Moreover, the consistent variation of IL-1beta and phospho-STAT3 expression in brain tissues, indicated a role of STAT3 pathway in IL-1beta production and anti-inflammatory effect of GB.	ginkgolide B	183-185	signal transducer and activator of transcription 3	Mus musculus	114-119
32507685-5	2020	The administration of Stattic, an inhibitor of STAT3, rescued the activation of astrocytes in primary cultured astrocytes and in the hippocampus of 6-month-old 5XFAD mice as well as impairments in learning and memory.	stattic	22-29	signal transducer and activator of transcription 3	Mus musculus	47-52
32626965-0	2020	Cholestatic models induced by lithocholic acid and alpha-naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.	Lithocholic Acid	30-46	signal transducer and activator of transcription 3	Mus musculus	146-151
32626965-0	2020	Cholestatic models induced by lithocholic acid and alpha-naphthylisothiocyanate: Different etiological mechanisms for liver injury but shared JNK/STAT3 signaling.	1-Naphthylisothiocyanate	51-79	signal transducer and activator of transcription 3	Mus musculus	146-151
32519243-6	2020	We show that the intracerebral administration of endozepines enhances satiety by targeting anorexigenic brain circuitry and induces STAT3 phosphorylation, a hallmark of leptin signaling.	Diazepam Binding Inhibitor	49-60	signal transducer and activator of transcription 3	Mus musculus	132-137
32519243-8	2020	Endozepines reversed high fat diet-induced obesity by reducing food intake and restored leptin-induced STAT3 phosphorylation in the hypothalamus.	Diazepam Binding Inhibitor	0-11	signal transducer and activator of transcription 3	Mus musculus	103-108
32519243-10	2020	Finally, endozepines, which induce ERK activation necessary for leptin transport into the brain in cultured tanycytes, require tanycytic leptin receptor expression to promote STAT3 phosphorylation in the hypothalamus.	Diazepam Binding Inhibitor	9-20	signal transducer and activator of transcription 3	Mus musculus	175-180
32584352-8	2020	STAT3-dependent IL-22 signalling and effects in keratinocytes are negatively regulated by the 310 nm UV-LED, which significantly ameliorated IMQ-induced psoriasis-like dermatitis development and reduced Th17 cytokine levels (IL-17A, IL-22) in serum and dorsal skin.	Imiquimod	141-144	signal transducer and activator of transcription 3	Mus musculus	0-5
33089278-1	2020	PURPOSE: Based on the Cre-Loxp gene knockout system, this study intended to construct tamoxifen-inducible STAT3 conditional knockout mice and verify the knockout efficiency.	Tamoxifen	86-95	signal transducer and activator of transcription 3	Mus musculus	106-111
32618105-0	2020	Dioscin elicits anti-tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer.	dioscin	0-7	signal transducer and activator of transcription 3	Mus musculus	90-95
32618105-8	2020	Furthermore, dioscin down-regulated STAT3 and JNK signalling pathways in macrophages in vitro.	dioscin	13-20	signal transducer and activator of transcription 3	Mus musculus	36-41
32618105-12	2020	In conclusion, dioscin may act as a new anti-tumour agent by inhibiting TAMs via JNK and STAT3 pathways in lung cancer.	dioscin	15-22	signal transducer and activator of transcription 3	Mus musculus	89-94
32627301-7	2020	Moreover, WWP2 formed a complex with SIRT1-STAT3, inhibiting the interaction between SIRT1 and STAT3, then reducing the inhibitory effect of SIRT1 on STAT3, ensuing promoting STAT3-K685 acetylation and STAT3-Y705 phosphorylation in angiotensin II-induced VSMCs and mice.	y705	208-212	signal transducer and activator of transcription 3	Mus musculus	43-48
32850781-10	2020	In cocaine administered mice, EV-Cy5-miR-124 delivered intranasally were detected in the CNS and significantly reduced the expression of inflammatory markers TLR4, MYD88, STAT3 and NF-kB p65 while also downregulating the microglial activation marker, Iba1.	ev-cy5-mir-124	30-44	signal transducer and activator of transcription 3	Mus musculus	171-176
32732870-0	2020	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1beta expression.	Serine	6-12	signal transducer and activator of transcription 3	Mus musculus	0-5
32732870-5	2020	Using a genetically engineered mouse model incapable of undergoing STAT3 Ser727 phosphorylation, we show ex vivo and in vivo that STAT3 Ser727 phosphorylation is critical for LPS-induced glycolytic reprogramming, production of the central immune response metabolite succinate and inflammatory cytokine production in a model of LPS-induced inflammation.	Succinic Acid	266-275	signal transducer and activator of transcription 3	Mus musculus	130-135
32895154-0	2020	[Bile acids regulate anorexigenic neuropeptide through p-STAT3-SOCS3 signaling in mouse hypothalamic cells].	Bile Acids and Salts	1-11	signal transducer and activator of transcription 3	Mus musculus	57-62
32895154-5	2020	Real-time PCR showed that the expression of POMC mRNA was significantly increased in the cells after treatment with 10 mumol/L tLCA or CDCA for 24 h. POMC-derived anorexigenic peptide alpha-MSH increased significantly in GT1-7 cells after treatment with 10 mumol/L tLCA or CDCA for 24 h. Treatment of the cells with tLCA or CDCA significantly increased the expressions of intracellular signaling proteins including p-STAT3, p-AKT and SOCS3.	Taurolithocholic Acid	127-131	signal transducer and activator of transcription 3	Mus musculus	417-422
32895154-5	2020	Real-time PCR showed that the expression of POMC mRNA was significantly increased in the cells after treatment with 10 mumol/L tLCA or CDCA for 24 h. POMC-derived anorexigenic peptide alpha-MSH increased significantly in GT1-7 cells after treatment with 10 mumol/L tLCA or CDCA for 24 h. Treatment of the cells with tLCA or CDCA significantly increased the expressions of intracellular signaling proteins including p-STAT3, p-AKT and SOCS3.	Chenodeoxycholic Acid	135-139	signal transducer and activator of transcription 3	Mus musculus	417-422
32895154-8	2020	The intracellular signaling proteins p-AKT, p-STAT3 and SOCS3 are likely involved in bile acid-induced anorexigenic peptide production.	Bile Acids and Salts	85-94	signal transducer and activator of transcription 3	Mus musculus	46-51
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	signal transducer and activator of transcription 3	Mus musculus	134-139
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	G(M1) Ganglioside	26-29	signal transducer and activator of transcription 3	Mus musculus	134-139
32712670-17	2020	The lopinavir-associated decidualization defects were attributed to a decrease in expression of transcription factor STAT3, known to regulate decidualization.	Lopinavir	4-13	signal transducer and activator of transcription 3	Mus musculus	117-122
32552417-0	2020	MCP-1 Priming Enhanced the Therapeutic Effects of Mesenchymal Stromal Cells on Contact Hypersensitivity by Activating the COX2-PGE2/STAT3 Pathway.	Dinoprostone	127-131	signal transducer and activator of transcription 3	Mus musculus	132-137
32396938-6	2020	Mechanistically, STAT3 transactivates MDH1 to sustain the malate-aspartate NADH shuttle activity and the HSC self-renewal and differentiation.	malic acid	58-64	signal transducer and activator of transcription 3	Mus musculus	17-22
32396938-6	2020	Mechanistically, STAT3 transactivates MDH1 to sustain the malate-aspartate NADH shuttle activity and the HSC self-renewal and differentiation.	Aspartic Acid	65-74	signal transducer and activator of transcription 3	Mus musculus	17-22
32396938-6	2020	Mechanistically, STAT3 transactivates MDH1 to sustain the malate-aspartate NADH shuttle activity and the HSC self-renewal and differentiation.	NAD	75-79	signal transducer and activator of transcription 3	Mus musculus	17-22
32732975-5	2020	Interestingly, we found that canonical signaling pathways that regulate iron, including the Bmp/Smad and IL-6/Jak2/Stat3 pathways, play indispensable roles in mediating AUR"s effects.	Iron	72-76	signal transducer and activator of transcription 3	Mus musculus	115-120
33089278-4	2020	Meanwhile, wild type and Stat3Col1ERT2 mice were both intraperitoneally injected with tamoxifen, the expression of STAT3 in the maxillary alveolar bone was observed by immunofluorescent staining to confirm the knockout effect in vivo.	Tamoxifen	86-95	signal transducer and activator of transcription 3	Mus musculus	25-30
33089278-6	2020	RESULTS: Real-time quantitative PCR and Western blotting results demonstrated that mRNA(P<0.05) and protein levels of STAT3 were significantly decreased (P<0.05) in BMSCs derived from Stat3Col1ERT2 mice by 4-OHT induced knockout in vitro.	4,17 beta-dihydroxy-4-androstene-3-one	206-211	signal transducer and activator of transcription 3	Mus musculus	118-123
33089278-6	2020	RESULTS: Real-time quantitative PCR and Western blotting results demonstrated that mRNA(P<0.05) and protein levels of STAT3 were significantly decreased (P<0.05) in BMSCs derived from Stat3Col1ERT2 mice by 4-OHT induced knockout in vitro.	4,17 beta-dihydroxy-4-androstene-3-one	206-211	signal transducer and activator of transcription 3	Mus musculus	184-189
32613952-6	2020	A docking study was performed and proved the strong affinity between curcumin and the proteins of STAT3, FASN, and AKT.	Curcumin	69-77	signal transducer and activator of transcription 3	Mus musculus	98-103
32774701-3	2020	Folic acid was used to induce kidney injury C57BL/6 mouse model followed by analysis of serum creatinine, renal weight ratio changes, renal pathological changes and STAT3/mTOR pathway changes.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	165-170
33133685-0	2020	Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma.	brusatol	0-8	signal transducer and activator of transcription 3	Mus musculus	20-25
33133685-6	2020	Since the expression of these two factors can be regulated by STAT3 signaling, we deciphered the influence of BT on modulation of this pathway.	brusatol	110-112	signal transducer and activator of transcription 3	Mus musculus	62-67
33133685-7	2020	BT suppressed the phosphorylation of STAT3Y705 and STAT3 depletion using siRNA resulted in the restoration of epithelial markers.	brusatol	0-2	signal transducer and activator of transcription 3	Mus musculus	37-42
33133685-9	2020	Conclusions: Overall, our results demonstrate that BT interferes with STAT3 induced metastasis by altering the expression of EMT-related proteins in HCC model.	brusatol	51-53	signal transducer and activator of transcription 3	Mus musculus	70-75
32661331-0	2020	Erlotinib can halt adenine induced nephrotoxicity in mice through modulating ERK1/2, STAT3, p53 and apoptotic pathways.	Erlotinib Hydrochloride	0-9	signal transducer and activator of transcription 3	Mus musculus	85-90
32661331-9	2020	Erlotinib markedly reduced fibrosis and tubular injury and decreased TGF-beta1, p-ERK1/2 and p-STAT3 (P < 0.5).	Erlotinib Hydrochloride	0-9	signal transducer and activator of transcription 3	Mus musculus	95-100
32641132-7	2020	RESULTS: Pharmacological inhibition of pY-STAT3 expression by BP-1-102 reduced the proinflammatory factors, suppressed coagulation activation, attenuated lung injury, alleviated vascular leakage and improved the survival rate in septic mice.	BP-1-102	62-70	signal transducer and activator of transcription 3	Mus musculus	42-47
32630199-9	2020	Flavanone derivatives of milk thistle inhibit TNFalpha/IFNgamma, NFkappaB, and STAT3, then inhibit the expression of FAT10.	flavanone	0-9	signal transducer and activator of transcription 3	Mus musculus	79-84
32144747-9	2020	Direct inhibition of TLR4 by geniposide led to the shutdown of TLR4/MyD88 pathway and STAT3/Sp1-dependent VEGF production.	geniposide	29-39	signal transducer and activator of transcription 3	Mus musculus	86-91
32144747-10	2020	However, a competitive agonist of TLR4, lipopolysaccharide (LPS), rescued STAT3/Sp1-related VEGF reduction in geniposide-inhibited HCC angiogenesis.	geniposide	110-120	signal transducer and activator of transcription 3	Mus musculus	74-79
32144747-11	2020	CONCLUSIONS AND IMPLICATIONS: The direct inhibitory effect of geniposide on TLR4/MyD88 activation contributes to the suppression of STAT3/Sp1-dependent VEGF overexpression in HCC angiogenesis and pulmonary metastasis, which is independent of regulating HIF-1alpha stabilization.	geniposide	62-72	signal transducer and activator of transcription 3	Mus musculus	132-137
32476221-0	2020	Miconazole inhibits signal transducer and activator of transcription 3 signaling by preventing its interaction with DNA damage-induced apoptosis suppressor.	Miconazole	0-10	signal transducer and activator of transcription 3	Mus musculus	20-70
32476221-2	2020	Moreover, DDIAS promotes tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3) via their interaction.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	53-103
32476221-2	2020	Moreover, DDIAS promotes tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3) via their interaction.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	105-110
32476221-3	2020	Here, we identified miconazole as an inhibitor of DDIAS/STAT3 interaction by screening a chemical library using a yeast two-hybrid assay.	Miconazole	20-30	signal transducer and activator of transcription 3	Mus musculus	56-61
32476221-5	2020	Furthermore, miconazole suppressed STAT3 tyrosine Y705 phosphorylation and the expression of its target genes, such as cyclin D1, survivin and snail but had no suppressive effect on the activation of ERK1/2 or AKT, which is involved in the survival of lung cancer.	Miconazole	13-23	signal transducer and activator of transcription 3	Mus musculus	35-40
32476221-5	2020	Furthermore, miconazole suppressed STAT3 tyrosine Y705 phosphorylation and the expression of its target genes, such as cyclin D1, survivin and snail but had no suppressive effect on the activation of ERK1/2 or AKT, which is involved in the survival of lung cancer.	Tyrosine	41-49	signal transducer and activator of transcription 3	Mus musculus	35-40
32476221-8	2020	Tyrosine phosphorylation of STAT3 at Y705 and expression of its targets, such as cyclin D1, survivin and snail, were decreased in miconazole-treated tumor tissues, as compared with those in vehicle-treated tumor tissues.	Tyrosine	0-8	signal transducer and activator of transcription 3	Mus musculus	28-33
32476221-8	2020	Tyrosine phosphorylation of STAT3 at Y705 and expression of its targets, such as cyclin D1, survivin and snail, were decreased in miconazole-treated tumor tissues, as compared with those in vehicle-treated tumor tissues.	Miconazole	130-140	signal transducer and activator of transcription 3	Mus musculus	28-33
32476221-9	2020	These data suggest that miconazole exerts an anti-cancer effect by suppressing STAT3 activation through inhibiting DDIAS/STAT3 binding.	Miconazole	24-34	signal transducer and activator of transcription 3	Mus musculus	79-84
32476221-9	2020	These data suggest that miconazole exerts an anti-cancer effect by suppressing STAT3 activation through inhibiting DDIAS/STAT3 binding.	Miconazole	24-34	signal transducer and activator of transcription 3	Mus musculus	121-126
32632241-8	2020	Mechanistically, DEX induced IL-6 secretion from aHSCs and promoted HCC progression via STAT3 activation.	Dexmedetomidine	17-20	signal transducer and activator of transcription 3	Mus musculus	88-93
32323562-7	2020	Furthermore, TEPP-46 treatment also suppressed the activation of the NOD-like receptor (NLR) family and pyrin domain-containing protein 3 (NLRP3) inflammasome by downregulating p-STAT3 and HIF1-alpha.	TEPP-46	13-20	signal transducer and activator of transcription 3	Mus musculus	179-184
32386234-11	2020	Trp regulated the DSS-induced immune response partly through attenuating the activation of toll-like receptor 4 (TLR4)-STAT3 signaling and nucleus p-65.	Tryptophan	0-3	signal transducer and activator of transcription 3	Mus musculus	119-124
32386234-11	2020	Trp regulated the DSS-induced immune response partly through attenuating the activation of toll-like receptor 4 (TLR4)-STAT3 signaling and nucleus p-65.	dss	18-21	signal transducer and activator of transcription 3	Mus musculus	119-124
32572733-9	2020	Curcumin was found to block mRNA expressions of non- SMAD genes EGFR, JNK-1, JAK1, JAK2, STAT-1, STAT-3, MAPK14, also of TGF-beta1 and SMAD genes like SMAD 2, SMAD 3.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	97-103
32618501-5	2020	Besides, PBA-Niclo-SLN effectively inhibited STAT3, CD44+/CD24- TNBC stem cell subpopulation, epithelial-mesenchymal transition markers.	pba-niclo-sln	9-22	signal transducer and activator of transcription 3	Mus musculus	45-50
32694788-0	2020	Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3.	Catecholamines	0-14	signal transducer and activator of transcription 3	Mus musculus	100-105
32694788-4	2020	Here, we report that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3).	Catecholamines	21-35	signal transducer and activator of transcription 3	Mus musculus	94-144
32694788-4	2020	Here, we report that catecholamines redirect FAs for oxidation through the phosphorylation of signal transducer and activator of transcription 3 (STAT3).	Catecholamines	21-35	signal transducer and activator of transcription 3	Mus musculus	146-151
32722030-0	2020	Vanillic Acid Improves Comorbidity of Cancer and Obesity through STAT3 Regulation in High-Fat-Diet-Induced Obese and B16BL6 Melanoma-Injected Mice.	Vanillic Acid	0-13	signal transducer and activator of transcription 3	Mus musculus	65-70
32657763-0	2020	HOTAIR expands the population of prostatic cancer stem-like cells and causes Docetaxel resistance via activating STAT3 signaling.	Docetaxel	77-86	signal transducer and activator of transcription 3	Mus musculus	113-118
32655542-13	2020	EZH2 methylated STAT3 and enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3, thereby increasing apoptosis and release of pro-inflammatory cytokines in ox-LDL-treated HUVECs.	Tyrosine	63-71	signal transducer and activator of transcription 3	Mus musculus	35-40
32655542-13	2020	EZH2 methylated STAT3 and enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3, thereby increasing apoptosis and release of pro-inflammatory cytokines in ox-LDL-treated HUVECs.	Tyrosine	63-71	signal transducer and activator of transcription 3	Mus musculus	35-40
33318871-7	2021	Results: The deficiency of endogenous H2S generated vascular remodeling with aggravated active and passive contraction, thicken aortic walls, collagen deposition, increased phosphorylation of STAT3, decreased production of PPARdelta and SOCS3 in aortas, which were reversed by NaHS.	Deuterium	38-41	signal transducer and activator of transcription 3	Mus musculus	192-197
33318871-8	2021	PPG inhibited expression of PPARdelta and SOCS3, stimulated the phosphorylation of STAT3, increased inflammatory molecules production and proliferation rate of VSMCs which could all be corrected by NaHS supply.	ppg	0-3	signal transducer and activator of transcription 3	Mus musculus	83-88
33318871-8	2021	PPG inhibited expression of PPARdelta and SOCS3, stimulated the phosphorylation of STAT3, increased inflammatory molecules production and proliferation rate of VSMCs which could all be corrected by NaHS supply.	sodium bisulfide	198-202	signal transducer and activator of transcription 3	Mus musculus	83-88
33318871-11	2021	On the contrary, PPARdelta antagonist GSK0660 exhibited opposite effects on vascular contraction in aortas, expressions of p-STAT3 and SOCS3 in VSMCs compared with GW501516.	GSK0660	38-45	signal transducer and activator of transcription 3	Mus musculus	125-130
32556081-0	2020	Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	66-71
32556081-0	2020	Curcumin against imiquimod-induced psoriasis of mice through IL-6/STAT3 signaling pathway.	Imiquimod	17-26	signal transducer and activator of transcription 3	Mus musculus	66-71
32774701-5	2020	The serum creatinine and renal weight ratio was increased with obvious lesions and upregulated STAT3 and p-mTOR level.	Creatinine	10-20	signal transducer and activator of transcription 3	Mus musculus	95-100
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	signal transducer and activator of transcription 3	Mus musculus	204-209
32626701-6	2020	More importantly, chaetocin abrogated the self-renewal of BCSCs (inhibition ratio: 80.1%) via the suppression of the KMT1A-GATA3-STAT3 circuit and other stemness-related pathways.	chaetocin	18-27	signal transducer and activator of transcription 3	Mus musculus	129-134
32626701-8	2020	In sum, chaetocin abrogated the stemness maintenance and tumor growth of BCSCs via the suppression of the KMT1A-GATA3-STAT3 circuit.	chaetocin	8-17	signal transducer and activator of transcription 3	Mus musculus	118-123
32669950-0	2020	Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways.	arnicolide D	0-12	signal transducer and activator of transcription 3	Mus musculus	102-107
32545266-0	2020	Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression.	epigallocatechin gallate	0-26	signal transducer and activator of transcription 3	Mus musculus	59-64
32545266-0	2020	Epigallocatechin-3-Gallate (EGCG)-Inducible SMILE Inhibits STAT3-Mediated Hepcidin Gene Expression.	epigallocatechin gallate	28-32	signal transducer and activator of transcription 3	Mus musculus	59-64
32606754-0	2020	Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways.	brevilin A	0-10	signal transducer and activator of transcription 3	Mus musculus	121-126
32606754-14	2020	BA significantly downregulated the expression of Akt, mTOR, Stat3 and their phosphorylation, and thus inhibiting the activation of the Akt/mTOR and STAT3 signaling pathways.	brevilin A	0-2	signal transducer and activator of transcription 3	Mus musculus	60-65
32606754-14	2020	BA significantly downregulated the expression of Akt, mTOR, Stat3 and their phosphorylation, and thus inhibiting the activation of the Akt/mTOR and STAT3 signaling pathways.	brevilin A	0-2	signal transducer and activator of transcription 3	Mus musculus	148-153
32516785-0	2021	Calcitonin gene-related peptide-induced phosphorylation of STAT3 in arcuate neurons is a link in the metabolic benefits of portal glucose.	Glucose	130-137	signal transducer and activator of transcription 3	Mus musculus	59-64
32626701-0	2020	Chaetocin Abrogates the Self-Renewal of Bladder Cancer Stem Cells via the Suppression of the KMT1A-GATA3-STAT3 Circuit.	chaetocin	0-9	signal transducer and activator of transcription 3	Mus musculus	105-110
32516785-11	2021	CONCLUSIONS: CGRP-induced phosphorylation of STAT3 in the ARC is part of the neural chain determining the hunger-modulating and glucose-lowering effects of IGN/portal glucose.	Glucose	128-135	signal transducer and activator of transcription 3	Mus musculus	45-50
32516785-11	2021	CONCLUSIONS: CGRP-induced phosphorylation of STAT3 in the ARC is part of the neural chain determining the hunger-modulating and glucose-lowering effects of IGN/portal glucose.	Glucose	167-174	signal transducer and activator of transcription 3	Mus musculus	45-50
32516785-12	2021	CONCLUSIONS: CGRP-induced phosphorylation of STAT3 in the ARC is part of the neural chain determining the hunger-modulating and glucose-lowering effects of IGN/portal glucose.	Glucose	128-135	signal transducer and activator of transcription 3	Mus musculus	45-50
32516785-12	2021	CONCLUSIONS: CGRP-induced phosphorylation of STAT3 in the ARC is part of the neural chain determining the hunger-modulating and glucose-lowering effects of IGN/portal glucose.	Glucose	167-174	signal transducer and activator of transcription 3	Mus musculus	45-50
32516785-4	2021	RESULTS: We report that portal glucose infusion decreases food intake and plasma glucose and induces in the hypothalamic arcuate nucleus (ARC) the phosphorylation of STAT3, the classic intracellular messenger of leptin signaling.	Glucose	31-38	signal transducer and activator of transcription 3	Mus musculus	166-171
32518521-5	2020	Results: Dietary fiber and sodium butyrate (NaB) decreased CRC burden by decreasing IL-6 receptor gp130 and blocking IL-6/JAK2/STAT3 axis activation in vitro and in vivo.	Butyric Acid	27-42	signal transducer and activator of transcription 3	Mus musculus	127-132
32518521-5	2020	Results: Dietary fiber and sodium butyrate (NaB) decreased CRC burden by decreasing IL-6 receptor gp130 and blocking IL-6/JAK2/STAT3 axis activation in vitro and in vivo.	nab	44-47	signal transducer and activator of transcription 3	Mus musculus	127-132
32272095-0	2020	Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3.	Erianin	21-28	signal transducer and activator of transcription 3	Mus musculus	135-140
31942696-0	2020	STAT3 inhibitory stattic enhances immunogenic cell death induced by chemotherapy in cancer cells.	stattic	17-24	signal transducer and activator of transcription 3	Mus musculus	0-5
31942696-11	2020	CONCLUSION: These findings indicate that STAT3 inhibitory stattic can increase ICD induced by DOX.	Doxorubicin	94-97	signal transducer and activator of transcription 3	Mus musculus	41-46
31916050-7	2020	Furthermore, Y-27632 potently and pleiotropically suppressed nuclear factor-kappaB (NF-kappaB) and signal transduction and transcriptional activator 3 (STAT3) activation as well as the activity of prosurvival genes that are dependent on these transcription factors.	Y 27632	13-20	signal transducer and activator of transcription 3	Mus musculus	99-150
32281211-6	2020	PCI34051 treatment also reduced the number of renal tubular epithelial cells arrested at the G2/M phase of the cell cycle and suppressed phosphorylation of Smad3, STAT3, beta-catenin, and expression of Snail after ureteral obstruction.	PCI 34051	0-8	signal transducer and activator of transcription 3	Mus musculus	163-168
32281218-0	2020	Sitagliptin ameliorates renal tubular injury in diabetic kidney disease via STAT3-dependent mitochondrial homeostasis through SDF-1alpha/CXCR4 pathway.	Sitagliptin Phosphate	0-11	signal transducer and activator of transcription 3	Mus musculus	76-81
31916050-7	2020	Furthermore, Y-27632 potently and pleiotropically suppressed nuclear factor-kappaB (NF-kappaB) and signal transduction and transcriptional activator 3 (STAT3) activation as well as the activity of prosurvival genes that are dependent on these transcription factors.	Y 27632	13-20	signal transducer and activator of transcription 3	Mus musculus	152-157
32472077-7	2020	Mechanistically, we establish that both tamoxifen and fulvestrant induce STAT3 phosphorylation.	Tamoxifen	40-49	signal transducer and activator of transcription 3	Mus musculus	73-78
31529728-7	2020	In contrast, hepatic and serum levels of the hepato-protective cytokine interleukin (IL)-6, its downstream signal transducer and transcription factor 3 (STAT3) activation in hepatocytes, as well hepatic MPhis IL-6 expression were markedly reduced in HIF-2alpha mye/- mice compared to WT mice post APAP challenge.	Acetaminophen	297-301	signal transducer and activator of transcription 3	Mus musculus	153-158
31846070-5	2020	Extensive in vitro and preclinical research has demonstrated that niclosamide was found to exert potent anticancer and anti-inflammatory properties by targeting STAT3, p65 NF-kappaB, and NFATc-1 signaling paradigm with minimal host toxicity.	Niclosamide	66-77	signal transducer and activator of transcription 3	Mus musculus	161-166
31846070-10	2020	Additionally, our results provided a preclinical rationale in imiquimod (IMQ)-induced BALB/c mouse model, where niclosamide diligently mitigated the IMQ-induced epidermal hyperplasia and inflammation by downregulating STAT3, p65 NF-kappaB, and NFATc-1 transcription factors along with Akt, Ki-67, and ICAM-1 protein expression.	Niclosamide	112-123	signal transducer and activator of transcription 3	Mus musculus	218-223
32198052-10	2020	Meanwhile, treatment with ML-265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	TEPP-46	26-32	signal transducer and activator of transcription 3	Mus musculus	75-125
32198052-10	2020	Meanwhile, treatment with ML-265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	TEPP-46	26-32	signal transducer and activator of transcription 3	Mus musculus	127-132
31904843-9	2020	Metformin upregulated the expression of p-AMPK, p-STAT1 and inhibited the expression of p-STAT3, p-mTOR in Ad-MSCs.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	90-95
32009061-8	2020	The number of phospho STAT3 expressed cells in the arcuate nucleus after leptin administration was increased in anagliptin treated mice compared to non-treated mice.	anagliptin	112-122	signal transducer and activator of transcription 3	Mus musculus	22-27
32489402-12	2020	Conclusion: These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control.	th2	89-92	signal transducer and activator of transcription 3	Mus musculus	174-179
32509786-5	2020	We found that STAT3 promotes the expression of genes involved in the mitochondrial oxidative phosphorylation (OXPHOS), and thereby promotes mitochondrial respiration and negatively regulates reactive oxygen species (ROS) production.	Reactive Oxygen Species	191-214	signal transducer and activator of transcription 3	Mus musculus	14-19
32509786-5	2020	We found that STAT3 promotes the expression of genes involved in the mitochondrial oxidative phosphorylation (OXPHOS), and thereby promotes mitochondrial respiration and negatively regulates reactive oxygen species (ROS) production.	Reactive Oxygen Species	216-219	signal transducer and activator of transcription 3	Mus musculus	14-19
32088220-0	2020	Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	66-71
32088220-5	2020	In GC cell lines, nanomolar concentrations of CuB decreased the phosphorylation of TYR-705 in STAT3 and suppressed STAT3 target gene expression, including c-Myc and Bcl-xL.	Tyrosine	83-86	signal transducer and activator of transcription 3	Mus musculus	94-99
32088220-8	2020	CuB in combination with the conventional chemotherapy drug cisplatin exerted enhanced cytotoxicity in GC cells, possibly due to the potentiated inhibition of STAT3 activation.	Cisplatin	59-68	signal transducer and activator of transcription 3	Mus musculus	158-163
32523357-4	2020	Results: Network results showed DWYG might be involved in some processes such as STAT cascade.	dwyg	32-36	signal transducer and activator of transcription 3	Mus musculus	81-85
32411291-0	2020	Huanglian Jiedu Decoction ameliorates DSS-induced colitis in mice via the JAK2/STAT3 signalling pathway.	dss	38-41	signal transducer and activator of transcription 3	Mus musculus	79-84
32411291-2	2020	In this paper, the effect of Huanglian Jiedu Decoction (HJD), a well-known traditional Chinese medicine with significant anti-inflammatory effect, on dextran sulphate sodium (DSS)-induced UC in mice and inhibition of JAK2/STAT3 pathway were investigated.	dss	175-178	signal transducer and activator of transcription 3	Mus musculus	222-227
32411289-10	2020	Mechanically, uvaol inhibits the pro-inflammatory ERK/STAT3 axis in both inflamed colonic tissues and macrophages.	uvaol	14-19	signal transducer and activator of transcription 3	Mus musculus	54-59
32362652-9	2020	Interestingly, treatment with Oridonin also resulted in decreased the infiltration of macrophages in renal tissues of AKI mice, which was associated with decreased expression and activation of AKT and its related signaling pathways, such as NF-kappaB and STAT3, suggesting that Oridonin attenuates AKI kidney injury via a mechanism associated with reducing the inflammatory response of macrophages in the AKI kidney.	oridonin	30-38	signal transducer and activator of transcription 3	Mus musculus	255-260
32362652-11	2020	Mechanistically, the addition of Oridonin reversed LPS-induced downregulation of AKT, NF-kappaB, and STAT3 expression and inflammatory response in macrophages, suggesting that Oridonin has a protective role, via the AKT-related signaling pathways, in reducing the inflammatory response of macrophages in AKI mice.	oridonin	33-41	signal transducer and activator of transcription 3	Mus musculus	101-106
32362652-11	2020	Mechanistically, the addition of Oridonin reversed LPS-induced downregulation of AKT, NF-kappaB, and STAT3 expression and inflammatory response in macrophages, suggesting that Oridonin has a protective role, via the AKT-related signaling pathways, in reducing the inflammatory response of macrophages in AKI mice.	oridonin	176-184	signal transducer and activator of transcription 3	Mus musculus	101-106
32483429-12	2020	An ACT001-biotin probe was used to verify that ACT001 bound to STAT3.	Biotin	10-16	signal transducer and activator of transcription 3	Mus musculus	63-68
32353505-6	2020	In vitro, HCP inhibited Th17 cell differentiation through the downregulation of phospho-STAT3, whereas it promoted Treg cell differentiation by upregulating phospho-STAT5.	hcp	10-13	signal transducer and activator of transcription 3	Mus musculus	88-93
31950153-4	2020	We have reported that niclosamide reduces growth and progression of endometriosis-like lesions via targeting STAT3 and NFkB signaling in a mouse model of endometriosis.	Niclosamide	22-33	signal transducer and activator of transcription 3	Mus musculus	109-114
32362823-0	2020	Bazedoxifene Attenuates Abdominal Aortic Aneurysm Formation via Downregulation of Interleukin-6/Glycoprotein 130/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Apolipoprotein E-Knockout Mice.	bazedoxifene	0-12	signal transducer and activator of transcription 3	Mus musculus	113-163
32362823-3	2020	However, it remains unclear whether Bazedoxifene (BAZ) could suppress the activation of IL-6/GP130/STAT3 in vascular cells and the formation of AAA.	bazedoxifene	36-48	signal transducer and activator of transcription 3	Mus musculus	99-104
32362823-3	2020	However, it remains unclear whether Bazedoxifene (BAZ) could suppress the activation of IL-6/GP130/STAT3 in vascular cells and the formation of AAA.	bazedoxifene	50-53	signal transducer and activator of transcription 3	Mus musculus	99-104
32362823-8	2020	Furthermore, BAZ suppressed the stimuli-induced (IL-6 or AngII) expression of P-STAT3, MMP2 and MMP9 in vascular smooth muscle cells (VSMCs).	bazedoxifene	13-16	signal transducer and activator of transcription 3	Mus musculus	80-85
32362823-9	2020	BAZ inhibited wound healing, colony formation and suppressed STAT3 nuclear translocation in vitro.	bazedoxifene	0-3	signal transducer and activator of transcription 3	Mus musculus	61-66
32362823-10	2020	In conclusion, these results indicated that BAZ downregulated IL-6/GP130/STAT3 signaling and interfered with AAA formation induced by AngII in ApoE-/- mice, which indicates a novel potential strategy for the prevention and therapy of AAA.	bazedoxifene	44-47	signal transducer and activator of transcription 3	Mus musculus	73-78
32134217-0	2020	Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects.	Valproic Acid	24-37	signal transducer and activator of transcription 3	Mus musculus	56-61
32134217-0	2020	Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects.	Valproic Acid	24-37	signal transducer and activator of transcription 3	Mus musculus	117-122
32134217-2	2020	Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is activated via tyrosine phosphorylation.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	0-50
32355553-8	2020	Western blotting and immunohistochemistry suggested that the phosphorylation of Stat3 at tyrosine 705 (pStat3 Y705) was down-regulated in early stage HCC.	Tyrosine	89-97	signal transducer and activator of transcription 3	Mus musculus	80-85
32290071-6	2020	EGCG down-regulated the canonical pathways in MDSCs, mainly through the Arg-1/iNOS/Nox2/NF-kappaB/STAT3 signaling pathway.	epigallocatechin gallate	0-4	signal transducer and activator of transcription 3	Mus musculus	98-103
32264893-8	2020	ME inhibits mitochondrial respiration at complex I of the electron transport chain, oxidizes peroxiredoxins, activates AMPK, and inhibits STAT3 phosphorylation, resulting in inhibition of the growth and proliferation of oral cancer cells.	methionylglutamic acid	0-2	signal transducer and activator of transcription 3	Mus musculus	138-143
31918016-13	2020	CONCLUSIONS: NaFTV and QrLx treatment could decrease symptoms and inflammatory colitis, by decreasing of FICZ concentration and AhR signaling in colon, resulting in reducing the expression of IL-6, STAT3, and RORgammat, whereas increasing the expression of FOXP3, consequently reducing the proportion of Th17 cells and increasing the proportion of Treg cells, respectively.	Sodium	13-18	signal transducer and activator of transcription 3	Mus musculus	198-203
32317968-6	2020	In addition, Trichomicin inhibited TNFalpha-induced activation of NF-kappaB and basal Stat3 signaling in vitro, which resulted in reduced expression of the immune checkpoint protein PD-L1 in tumor and stromal cells.	trichomicin	13-24	signal transducer and activator of transcription 3	Mus musculus	86-91
32081779-1	2020	Corosolic acid (CA), a natural pentacyclic triterpenoid, exhibits antitumor and synergistic therapy effect with chemotherapeutic drugs mainly through inhibiting STAT3 activation.	corosolic acid	0-14	signal transducer and activator of transcription 3	Mus musculus	161-166
32411754-9	2020	Nuclear phospho-STAT3Tyr705 was increased dramatically following DEX treatment, and TMPRSS2 upregulation was significantly suppressed by the STAT3 inhibitor WP1066.	Dexmedetomidine	65-68	signal transducer and activator of transcription 3	Mus musculus	16-21
32411754-9	2020	Nuclear phospho-STAT3Tyr705 was increased dramatically following DEX treatment, and TMPRSS2 upregulation was significantly suppressed by the STAT3 inhibitor WP1066.	WP1066	157-163	signal transducer and activator of transcription 3	Mus musculus	16-21
32411754-16	2020	Conclusions: This study provides evidence that DEX upregulates TMPRSS2 expression via the activation of alpha2-adrenergic receptor/STAT3 signaling and promotes TMPRSS2 secretion in exosomes through Rab11, thus resulting in degradation of the ECM, which is responsible for DEX-induced migration of breast cancer cells.	Dexmedetomidine	47-50	signal transducer and activator of transcription 3	Mus musculus	131-136
32609742-8	2020	Immunohistochemistry showed stronger phosphorylated STAT3 (pSTAT3) and MYC staining in PanINs from diabetic KP mice than in those from euglycemic counterparts.	panins	87-93	signal transducer and activator of transcription 3	Mus musculus	52-57
32539921-8	2020	Western blot analysis showed that the STAT3, Akt, and Erk signaling pathways are involved in AG490 treatment.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	93-98	signal transducer and activator of transcription 3	Mus musculus	38-43
32539921-9	2020	This study demonstrated for the first time that JAK2 inhibition by AG490 may play a crucial role in TNF-alpha-induced apoptosis by inhibiting autophagy and inhibiting the STAT3, Akt, and Erk signaling pathways.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	67-72	signal transducer and activator of transcription 3	Mus musculus	171-176
32326790-1	2021	Introduction The expression levels of signal transducer and activator of transcription 3 (STAT3) protein and Fascin-1 were inhibited using the STAT3 inhibitor BP-1-102 and RNA interference, respectively, to investigate the expression of AtT20 in mouse pituitary cells.	BP-1-102	159-167	signal transducer and activator of transcription 3	Mus musculus	38-88
32326790-1	2021	Introduction The expression levels of signal transducer and activator of transcription 3 (STAT3) protein and Fascin-1 were inhibited using the STAT3 inhibitor BP-1-102 and RNA interference, respectively, to investigate the expression of AtT20 in mouse pituitary cells.	BP-1-102	159-167	signal transducer and activator of transcription 3	Mus musculus	90-95
32326790-1	2021	Introduction The expression levels of signal transducer and activator of transcription 3 (STAT3) protein and Fascin-1 were inhibited using the STAT3 inhibitor BP-1-102 and RNA interference, respectively, to investigate the expression of AtT20 in mouse pituitary cells.	BP-1-102	159-167	signal transducer and activator of transcription 3	Mus musculus	143-148
32326790-4	2021	After inhibiting Fascin-1, the expression of STAT3 decreased, the expression of N-cadherin decreased, and the expression of E-cadherin increased.Conclusion BP-1-102 is a novel drug with a great potential in pituitary tumors.	BP-1-102	156-164	signal transducer and activator of transcription 3	Mus musculus	45-50
32397282-8	2020	Rapamycin augmented the activation of Akt1, Akt2, and Stat3, and maintained the contractile phenotype of aortic smooth muscle cells.	Sirolimus	0-9	signal transducer and activator of transcription 3	Mus musculus	54-59
32032598-8	2020	In addition, kappa-opioid receptor activation increased STAT3 phosphorylation and OPA1 expression, which were blockaded by nor-BNI.	norbinaltorphimine	123-130	signal transducer and activator of transcription 3	Mus musculus	56-61
32032598-10	2020	Overall, our data for the first time provide evidence that kappa-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to MI/R injury via STAT3-OPA1 pathway.	Arginine	163-164	signal transducer and activator of transcription 3	Mus musculus	176-181
32087254-9	2020	Among Th17 cell-related factors, DNCB treatment increased mRNA expression of IL-6, IL-17, IL-23, STAT3, and ROR-gammat, but reduced TGF-beta and SOCS 3; While artesunate reverse these changes.	Dinitrochlorobenzene	33-37	signal transducer and activator of transcription 3	Mus musculus	97-102
32087254-10	2020	Compared with the model group, artesunate promoted SOCS3 protein and significantly inhibited ROR-gammat protein and STAT3 phosphorylation.	Artesunate	31-41	signal transducer and activator of transcription 3	Mus musculus	116-121
32528831-4	2020	Here we investigated that signal transducer and activator of transcription 3 (STAT3)-mechanistic target of rapamycin (mTOR) signaling mediates the suppression of ghrelin induced by IL-27.	Sirolimus	107-116	signal transducer and activator of transcription 3	Mus musculus	26-76
32528831-4	2020	Here we investigated that signal transducer and activator of transcription 3 (STAT3)-mechanistic target of rapamycin (mTOR) signaling mediates the suppression of ghrelin induced by IL-27.	Sirolimus	107-116	signal transducer and activator of transcription 3	Mus musculus	78-83
32101031-8	2020	We treated mice with a small-molecule inhibitor of Stat3 (TTI-101) and found improved glucose tolerance and insulin signaling in skeletal muscles of mice with CKD or fed a HFD.	C188-9	58-65	signal transducer and activator of transcription 3	Mus musculus	51-56
32101031-8	2020	We treated mice with a small-molecule inhibitor of Stat3 (TTI-101) and found improved glucose tolerance and insulin signaling in skeletal muscles of mice with CKD or fed a HFD.	Glucose	86-93	signal transducer and activator of transcription 3	Mus musculus	51-56
32101031-9	2020	Finally, we uncovered improved glucose tolerance in mice with muscle-specific Stat3 KO vs. results in Stat3f/f mice in response to the HFD.	Glucose	31-38	signal transducer and activator of transcription 3	Mus musculus	78-83
32101031-11	2020	Inhibition of Stat3 by TTI-101 could be developed into clinical strategies to improve muscle insulin signaling in inflammation and other catabolic diseases.	C188-9	23-30	signal transducer and activator of transcription 3	Mus musculus	14-19
30810974-11	2020	Moreover, BBP treatment remarkably suppressed the STAT3 phosphorylation and modulated the expression of critical target genes including Bcl-2, Bax, Cyclin D1, CDK4 and VEGF-A in HCC mice.	bbp	10-13	signal transducer and activator of transcription 3	Mus musculus	50-55
30810974-12	2020	CONCLUSION: BBP exerts its anti-cancer activities via suppressing STAT3 signaling pathway and affecting multiple intracellular targets.	bbp	12-15	signal transducer and activator of transcription 3	Mus musculus	66-71
32267176-5	2020	There was a significantly decreased expression of STAT3 and its targets c-Myc and cyclin D3 in 4T1 cells treated with the Zn(S-pr-thiosal)2 complex thus contributing to G1/S cell cycle arrest and/or apoptosis.	zn(s-pr-thiosal)2	122-139	signal transducer and activator of transcription 3	Mus musculus	50-55
32243691-7	2020	Meanwhile, melatonin inhibited STAT3 phosphorylation, down-regulated miR-21-5p expression, and up-regulated Spry1 and PTEN expression.	Melatonin	11-20	signal transducer and activator of transcription 3	Mus musculus	31-36
32109485-0	2020	Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways.	SB939 compound	0-11	signal transducer and activator of transcription 3	Mus musculus	126-131
32109485-0	2020	Pracinostat (SB939), a histone deacetylase inhibitor, suppresses breast cancer metastasis and growth by inactivating the IL-6/STAT3 signalling pathways.	SB939 compound	13-18	signal transducer and activator of transcription 3	Mus musculus	126-131
32389179-5	2020	Conoidin A treatment also inhibited EPI-stimulated signal molecules, including signal transducer and activator of transcription-3, AKT and mitogen-activated protein kinase 1/2.	conoidin A	0-10	signal transducer and activator of transcription 3	Mus musculus	79-129
32343679-8	2020	HE staining showed obvious inflammation in mice injected with cells that were silenced for STAT3 and injected with PD-L1 antibody.	Helium	0-2	signal transducer and activator of transcription 3	Mus musculus	91-96
32670814-6	2020	KRG inhibited DSS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by suppressing activation of nuclear factor-kappa B (NF-kappaB) and signal transducer and activation of transcription 3 (STAT3).	Dextran Sulfate	14-17	signal transducer and activator of transcription 3	Mus musculus	176-227
32670814-6	2020	KRG inhibited DSS-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) by suppressing activation of nuclear factor-kappa B (NF-kappaB) and signal transducer and activation of transcription 3 (STAT3).	Dextran Sulfate	14-17	signal transducer and activator of transcription 3	Mus musculus	229-234
32670814-9	2020	The up-regulation of COX-2, iNOS, c-Myc and Cyclin D1 by AOM plus DSS was attenuated in KRG fed mice which was associated with suppression of NF-kappaB and STAT3 activation.	Dextran Sulfate	66-69	signal transducer and activator of transcription 3	Mus musculus	156-161
32352029-2	2020	Experiments utilizing a patient-derived (PDX) DCIS Mouse INtraDuctal (MIND) animal model combined with ChIP-exo and RNA sequencing revealed that the formation of protein complexes between B Cell Lymphoma-9 (BCL9), phosphoserine 727 STAT3 (PS-727-STAT3) and non-STAT3 transcription factors on chromatin enhancers lead to subsequent transcription of key drivers of DCIS malignancy.	Phosphoserine	214-227	signal transducer and activator of transcription 3	Mus musculus	232-237
32352029-2	2020	Experiments utilizing a patient-derived (PDX) DCIS Mouse INtraDuctal (MIND) animal model combined with ChIP-exo and RNA sequencing revealed that the formation of protein complexes between B Cell Lymphoma-9 (BCL9), phosphoserine 727 STAT3 (PS-727-STAT3) and non-STAT3 transcription factors on chromatin enhancers lead to subsequent transcription of key drivers of DCIS malignancy.	Phosphoserine	214-227	signal transducer and activator of transcription 3	Mus musculus	246-251
32352029-2	2020	Experiments utilizing a patient-derived (PDX) DCIS Mouse INtraDuctal (MIND) animal model combined with ChIP-exo and RNA sequencing revealed that the formation of protein complexes between B Cell Lymphoma-9 (BCL9), phosphoserine 727 STAT3 (PS-727-STAT3) and non-STAT3 transcription factors on chromatin enhancers lead to subsequent transcription of key drivers of DCIS malignancy.	Phosphoserine	214-227	signal transducer and activator of transcription 3	Mus musculus	246-251
32134217-2	2020	Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is activated via tyrosine phosphorylation.	Tyrosine	107-115	signal transducer and activator of transcription 3	Mus musculus	52-57
31917285-0	2020	Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-kappaB and STAT3 in an asthma mouse model.	baohuoside I	0-12	signal transducer and activator of transcription 3	Mus musculus	113-118
31917285-10	2020	In both OVA-induced mouse model of asthma and TGF-beta1-induced ASMCs, Icariside II decreased IkappaBalpha degradation, nuclear translocation of NF-kappaB p65 and STAT3 phophorylation, indicating an inactivation of NF-kappaB and STAT3 in the presence of Icariside II.	baohuoside I	71-83	signal transducer and activator of transcription 3	Mus musculus	163-168
31917285-10	2020	In both OVA-induced mouse model of asthma and TGF-beta1-induced ASMCs, Icariside II decreased IkappaBalpha degradation, nuclear translocation of NF-kappaB p65 and STAT3 phophorylation, indicating an inactivation of NF-kappaB and STAT3 in the presence of Icariside II.	baohuoside I	71-83	signal transducer and activator of transcription 3	Mus musculus	229-234
31917285-11	2020	Therefore, we demonstrate that Icariside II attenuates eosinophils-induced airway inflammation and remodeling in asthmatic mice and inhibits TGF-beta1-induced cell proliferation and migration in ASMCs via suppressing NF-kappaB and STAT3 signalings.	baohuoside I	31-43	signal transducer and activator of transcription 3	Mus musculus	231-236
32062080-0	2020	Astilbin promotes the induction of regulatory NK1.1- CD4+ NKG2D+ T cells through the PI3K, STAT3, and MAPK signaling pathways.	astilbin	0-8	signal transducer and activator of transcription 3	Mus musculus	91-96
31469186-8	2020	Importantly, hepatectomy-induced hyperactivation of CyclinD1 and liver regeneration in CREBZF LKO mice was reversed by selective STAT3 inhibitor cucurbitacin I.	cucurbitacin I	145-159	signal transducer and activator of transcription 3	Mus musculus	129-134
31810886-0	2020	Sinomenine hydrochloride inhibits the progression of plasma cell mastitis by regulating IL-6/JAK2/STAT3 pathway.	sinomenine	0-24	signal transducer and activator of transcription 3	Mus musculus	98-103
31810886-10	2020	Mechanistically, we demonstrated that SH inhibited the progression of PCM mainly through downregulating IL-6/JAK2/STAT3 levels.	sinomenine	38-40	signal transducer and activator of transcription 3	Mus musculus	114-119
31810886-11	2020	Collectively, our results suggested that SH could inhibit the progression of PCM by suppressing IL-6/JAK2/STAT3 cascades and ultimately achieve a therapeutic effect in PCM.	sinomenine	41-43	signal transducer and activator of transcription 3	Mus musculus	106-111
32062080-8	2020	Finally, the PI3K, STAT3, and MAPK signaling pathways are involved in the induction of NK1.1- CD4+ NKG2D+ T cells by astilbin.	astilbin	117-125	signal transducer and activator of transcription 3	Mus musculus	19-24
31949002-3	2020	Previously, we have shown that STAT3 is a key biomarker of therapeutic resistance to gemcitabine treatment in PDAC which can be overcome by combined inhibition of the Src and EGFR pathways.	gemcitabine	85-96	signal transducer and activator of transcription 3	Mus musculus	31-36
32146299-10	2020	RESULTS: We discovered that several fully synthetic pseurotin analogs were able to decrease the production of IgE in stimulated B-cells with potency comparable to that of pseurotins A and D. We found that the two natural pseurotins and the active synthetic analogs inhibited the phosphorylation of STAT3, STAT5 and STAT6 proteins in stimulated B-cells, resulting in the inhibition of B-cell proliferation and differentiation into the plasma cells.	pseurotin	52-61	signal transducer and activator of transcription 3	Mus musculus	298-303
32146299-12	2020	CONCLUSION: Our results advance the current mechanistic understanding of the pseurotin-induced inhibition of IgE production in B-cells by linking the effect to STAT signaling, and associated modulation of B-cell proliferation and differentiation.	pseurotin	77-86	signal transducer and activator of transcription 3	Mus musculus	160-164
32164044-8	2020	By Western blot detection, we found Bazedoxifene exhibited an inhibition of STAT3 activation in mice three hours and 8 weeks after TAC.	bazedoxifene	36-48	signal transducer and activator of transcription 3	Mus musculus	76-81
32257389-0	2020	Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/STAT3 pathway.	Atorvastatin	0-12	signal transducer and activator of transcription 3	Mus musculus	135-140
32164044-11	2020	In H9c2 myoblasts, Bazedoxifene suppressed the IL-6-induced STAT3 activation.	bazedoxifene	19-31	signal transducer and activator of transcription 3	Mus musculus	60-65
32257389-9	2020	Supplementation with exogenous IL-6 reversed both atorvastatin-induced suppression of STAT3 phosphorylation and hTERT expression and atorvastatin-induced senescence.	Atorvastatin	50-62	signal transducer and activator of transcription 3	Mus musculus	86-91
32257389-8	2020	Atorvastatin-induced senescence was independent of p53, p14, and p16, and atorvastatin not only decreased the secretion of IL-6, a major senescence-associated secretory phenotype (SASP) factor, and the phosphorylation of STAT3 but also inhibited the expression of hTERT, a catalytic subunit of telomerase.	Atorvastatin	74-86	signal transducer and activator of transcription 3	Mus musculus	221-226
32257389-10	2020	Overexpression of constitutively activated STAT3 rescued HCC cells from atorvastatin-induced hTERT suppression and senescence.	Atorvastatin	72-84	signal transducer and activator of transcription 3	Mus musculus	43-48
32257389-12	2020	Consistent with these results, atorvastatin decreased the IL-6, p-STAT3, and hTERT levels and increased beta-gal expression in tumor sections.	Atorvastatin	31-43	signal transducer and activator of transcription 3	Mus musculus	66-71
32257389-13	2020	Taken together, these data indicate that atorvastatin can induce atypical cellular senescence in HCC cells to inhibit tumor growth, an effect mediated by downregulation of hTERT through suppression of the IL-6/STAT3 pathway.	Atorvastatin	41-53	signal transducer and activator of transcription 3	Mus musculus	210-215
32216811-6	2020	After being incubated in osteogenic induction medium for 3 weeks, Alizarin Red staining and western blot were used to examine the calcium deposit and osteogenic markers in Stat3 overexpression in mBMSC-sh-Ror2.	Calcium	130-137	signal transducer and activator of transcription 3	Mus musculus	172-177
32216811-10	2020	The overexpression of Stat3 in mBMSC-sh-Ror2 cells rescued the calcium deposit and expression of Runx2, osterix, and OPN to a level comparable to normal mBMSCs.	Calcium	63-70	signal transducer and activator of transcription 3	Mus musculus	22-27
32224876-11	2020	The beneficial effects of phenformin are probably due to inhibition of the STAT3 pathway and mitochondrial complex I.	Phenformin	26-36	signal transducer and activator of transcription 3	Mus musculus	75-80
32231468-0	2020	Activation of CREB Protein With Tabersonine Attenuates STAT3 During Atherosclerosis in Apolipoprotein E-Deficient Mice.	tabersonine	32-43	signal transducer and activator of transcription 3	Mus musculus	55-60
32256954-0	2020	Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid beta-Oxidation.	Fatty Acids	114-124	signal transducer and activator of transcription 3	Mus musculus	92-97
32231468-13	2020	Conclusion: These results suggested that tabersonine ameliorates the expression of STAT-3 by activating CREB protein in atherosclerotic ApoE-deficient mice.	tabersonine	41-52	signal transducer and activator of transcription 3	Mus musculus	83-89
32176678-8	2020	In vivo, we found that DHA can reduce lung metastasis formation caused by CSCs and prolong survival in mice, and can inhibit STAT3 activation, downregulate MMP-9, and upregulate E-cadherin in lung metastatic tumors.	artenimol	23-26	signal transducer and activator of transcription 3	Mus musculus	125-130
32256354-0	2020	Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment.	Flavonoids	0-9	signal transducer and activator of transcription 3	Mus musculus	89-94
32176678-9	2020	CONCLUSIONS Taken together, our findings indicate that CSCs possess stronger invasive and metastatic capabilities than non-CSCs, and DHA inhibits invasion and prevents metastasis induced by CSCs by inhibiting STAT3 activation.	artenimol	133-136	signal transducer and activator of transcription 3	Mus musculus	209-214
32195263-11	2020	Additionally, myricetin inhibited the activation of nuclear factor (NF)-kappaB signaling and the phosphorylation of the signal transducer and activation of transcription 3 (STAT3) in LPS-stimulated RAW264.7 macrophages.	myricetin	14-23	signal transducer and activator of transcription 3	Mus musculus	120-171
32145511-0	2020	Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome.	muscone	0-7	signal transducer and activator of transcription 3	Mus musculus	134-139
32145511-5	2020	We found that muscone suppressed microglial activation-mediated inflammatory response through the NADPH oxidase 4 (NOX4)/janus kinase 2-signal transducer and activator of transcription 3 (JAK2-STAT3) pathway and pyrin-domain-containing 3 (NLRP3) inflammasome.	muscone	14-21	signal transducer and activator of transcription 3	Mus musculus	193-198
32145511-7	2020	Furthermore, muscone inhibited the CFA-induced NOX4, p-JAK2/p-STAT3, and NLRP3 inflammasome expression in spinal cord of mice.	muscone	13-20	signal transducer and activator of transcription 3	Mus musculus	62-67
32145511-8	2020	In conclusion, this study uncovered that muscone relieved inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome.	muscone	41-48	signal transducer and activator of transcription 3	Mus musculus	175-180
32145512-0	2020	Dexmedetomidine preconditioning alleviated murine liver ischemia and reperfusion injury by promoting macrophage M2 activation via PPARgamma/STAT3 signaling.	Dexmedetomidine	0-15	signal transducer and activator of transcription 3	Mus musculus	140-145
32145512-10	2020	Signaling pathway analysis revealed that peroxisome proliferator-activated receptor-gamma (PPARgamma)/ STAT3 activation was upregulated in BMDMs with dexmedetomidine pretreatment.	Dexmedetomidine	150-165	signal transducer and activator of transcription 3	Mus musculus	103-108
32145512-13	2020	CONCLUSIONS: Our results indicate that dexmedetomidine preconditioning inhibited intrahepatic proinflammatory innate immune activation by promoting macrophage M2 activation in a PPARgamma/STAT3 dependent manner.	Dexmedetomidine	39-54	signal transducer and activator of transcription 3	Mus musculus	188-193
32200265-0	2020	STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation.	Serine	76-82	signal transducer and activator of transcription 3	Mus musculus	0-5
32200265-2	2020	The uncontrolled activation of STAT3 has traditionally been assigned to its elevated phosphorylation at tyrosine 705 (pY705) and associated nuclear transcriptional activity.	Tyrosine	104-112	signal transducer and activator of transcription 3	Mus musculus	31-36
32200265-3	2020	By contrast, a transcriptional role for serine 727 phosphorylation (pS727) of STAT3 has recently emerged, suggesting that pS727 may account for the pathological activity of STAT3 in certain disease settings.	Serine	40-46	signal transducer and activator of transcription 3	Mus musculus	78-83
32200265-3	2020	By contrast, a transcriptional role for serine 727 phosphorylation (pS727) of STAT3 has recently emerged, suggesting that pS727 may account for the pathological activity of STAT3 in certain disease settings.	Serine	40-46	signal transducer and activator of transcription 3	Mus musculus	173-178
32195263-11	2020	Additionally, myricetin inhibited the activation of nuclear factor (NF)-kappaB signaling and the phosphorylation of the signal transducer and activation of transcription 3 (STAT3) in LPS-stimulated RAW264.7 macrophages.	myricetin	14-23	signal transducer and activator of transcription 3	Mus musculus	173-178
31881484-0	2020	Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways.	taxifolin	0-9	signal transducer and activator of transcription 3	Mus musculus	124-129
31881484-7	2020	Further data show that TXL can inhibit Notch1 and Jak2/Stat3 signal pathways.	taxifolin	23-26	signal transducer and activator of transcription 3	Mus musculus	55-60
31881484-8	2020	In summary, TXL may be able to treat psoriasis by regulating Th cells differentiation via inhibiting Notch1 and Jak2/Stat3 pathways.	taxifolin	12-15	signal transducer and activator of transcription 3	Mus musculus	117-122
31953926-9	2020	Additionally, STAT3 positively regulated HOTAIR expression, which was also negatively modulated by propofol.	Propofol	99-107	signal transducer and activator of transcription 3	Mus musculus	14-19
31958751-0	2020	MiR-526b-3p mediates doxorubicin-induced cardiotoxicity by targeting STAT3 to inactivate VEGFA.	Doxorubicin	21-32	signal transducer and activator of transcription 3	Mus musculus	69-74
31958751-11	2020	Overall, miR-526b-3p accelerated doxorubicin-induced cardiotoxicity through modulating STAT3/VEGFA, highlighting that targeting miR-526b-3p as a potential method to protect against DOX-induced cardiac dysfunction.	Doxorubicin	33-44	signal transducer and activator of transcription 3	Mus musculus	87-92
31958751-11	2020	Overall, miR-526b-3p accelerated doxorubicin-induced cardiotoxicity through modulating STAT3/VEGFA, highlighting that targeting miR-526b-3p as a potential method to protect against DOX-induced cardiac dysfunction.	Doxorubicin	181-184	signal transducer and activator of transcription 3	Mus musculus	87-92
32245588-13	2020	Remarkably, the mechanism of action of BM was related to the reduction of ethanol-induced NF-kappaB and STAT3 phosphorylation levels in liver.	Ethanol	74-81	signal transducer and activator of transcription 3	Mus musculus	104-109
32245588-15	2020	Taken together, our results demonstrate a beneficial effect of BM on ethanol-induced liver injury via a mechanism associated with inactivation of NF-kappaB, STAT3 and ERK pathway, which gives insight into the further evaluation of the therapeutic potential of BM for ALD.	Ethanol	69-76	signal transducer and activator of transcription 3	Mus musculus	157-162
32020680-6	2020	In H9C2 and primary cardiomyocytes, Rap1 knockdown or knockout significantly suppressed hypoxia/reoxygenation (H/R)-induced cell injury and apoptosis through increasing the phosphorylation/activation of STAT3 at site Ser727 and translocation of STAT3 to the nucleus.	seryl-seryl-seryl-arginine	217-220	signal transducer and activator of transcription 3	Mus musculus	203-208
32020680-8	2020	Furthermore, co-immunoprecipitation assay revealed a direct interaction between Rap1 and STAT3, but not JAK2, suggesting that the association of Rap1 with STAT3 may contribute to the reduced activity of STAT3 (Ser727 ) upon H/R stimulation.	seryl-seryl-seryl-arginine	210-216	signal transducer and activator of transcription 3	Mus musculus	89-94
32020680-8	2020	Furthermore, co-immunoprecipitation assay revealed a direct interaction between Rap1 and STAT3, but not JAK2, suggesting that the association of Rap1 with STAT3 may contribute to the reduced activity of STAT3 (Ser727 ) upon H/R stimulation.	seryl-seryl-seryl-arginine	210-216	signal transducer and activator of transcription 3	Mus musculus	155-160
32020680-8	2020	Furthermore, co-immunoprecipitation assay revealed a direct interaction between Rap1 and STAT3, but not JAK2, suggesting that the association of Rap1 with STAT3 may contribute to the reduced activity of STAT3 (Ser727 ) upon H/R stimulation.	seryl-seryl-seryl-arginine	210-216	signal transducer and activator of transcription 3	Mus musculus	155-160
31309353-10	2020	Phosphorylation of STAT3 at two crucial residues, Tyr-705 and Ser-727, allows its entry inside the nucleus and upregulates the expression of protein kinase G-1 (PKG1) which evokes cardioprotective signaling.	Tyrosine	50-53	signal transducer and activator of transcription 3	Mus musculus	19-24
31309353-10	2020	Phosphorylation of STAT3 at two crucial residues, Tyr-705 and Ser-727, allows its entry inside the nucleus and upregulates the expression of protein kinase G-1 (PKG1) which evokes cardioprotective signaling.	Serine	62-65	signal transducer and activator of transcription 3	Mus musculus	19-24
31931366-5	2020	Western blotting analysis illustrated that DMB remarkably inhibited Con A-induced phosphorylation of IKK, IkappaB, NF-kappaB p65, ERK, JNK, p38 MAPK and STAT3 induced by Con A.	demethyleneberberine	43-46	signal transducer and activator of transcription 3	Mus musculus	153-158
33490963-8	2020	In addition, IRF5 ASO treatment in 1K Pkd1 mice reduced Il6 expression in resident macrophages, which was correlated with reduced STAT3 phosphorylation and downstream p-STAT3 target gene expression.	Oligonucleotides, Antisense	18-21	signal transducer and activator of transcription 3	Mus musculus	130-135
32065498-5	2020	The effects of a natural alkaloid, sanguinarine, on HIF-1alpha and STAT3 colocalization and interaction were evaluated in vitro and mouse xenograft models.	sanguinarine	35-47	signal transducer and activator of transcription 3	Mus musculus	67-72
33490963-8	2020	In addition, IRF5 ASO treatment in 1K Pkd1 mice reduced Il6 expression in resident macrophages, which was correlated with reduced STAT3 phosphorylation and downstream p-STAT3 target gene expression.	Oligonucleotides, Antisense	18-21	signal transducer and activator of transcription 3	Mus musculus	169-174
32016448-0	2020	Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet-induced obese mice via endoplasmic reticulum stress and p-STAT3/STAT3 signaling.	Ginsenosides	0-12	signal transducer and activator of transcription 3	Mus musculus	140-145
31802363-6	2020	Furthermore, MCAO/R caused activation of STAT3, a downstream mediator of S1P signaling, which was suppressed by postoperative probucol administration.	Probucol	126-134	signal transducer and activator of transcription 3	Mus musculus	41-46
31922209-0	2020	Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation.	Carbon Tetrachloride	62-82	signal transducer and activator of transcription 3	Mus musculus	87-92
32016448-0	2020	Ginsenosides reduce body weight and ameliorate hepatic steatosis in high fat diet-induced obese mice via endoplasmic reticulum stress and p-STAT3/STAT3 signaling.	Ginsenosides	0-12	signal transducer and activator of transcription 3	Mus musculus	146-151
31811869-7	2020	We found that BTBR mice treated with AG126 exhibited significant decreases in IL-21R-, IL-21-, IL-22-, TNF-alpha-, NOS2-, STAT3-producing, and increases in IL-27- and Foxp3-producing, CD8+ T cells.	btbr	14-18	signal transducer and activator of transcription 3	Mus musculus	122-127
31811869-7	2020	We found that BTBR mice treated with AG126 exhibited significant decreases in IL-21R-, IL-21-, IL-22-, TNF-alpha-, NOS2-, STAT3-producing, and increases in IL-27- and Foxp3-producing, CD8+ T cells.	AG 127	37-42	signal transducer and activator of transcription 3	Mus musculus	122-127
31811869-8	2020	Our results further demonstrated that AG126 treatment effectively decreased IL-21, IL-22, IL-1beta, TNF-alpha, NOS2, JAK1, and STAT3, and increased IL-27 and Foxp3 mRNA and protein expression in brain tissues.	AG 127	38-43	signal transducer and activator of transcription 3	Mus musculus	127-132
32194752-0	2020	Inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma mechanisms of dioscin.	dioscin	90-97	signal transducer and activator of transcription 3	Mus musculus	19-24
32194752-6	2020	The present study investigated whether inhibition of STAT3 signaling is involved in the anti-melanoma effects of dioscin.	dioscin	113-120	signal transducer and activator of transcription 3	Mus musculus	53-58
32194752-8	2020	Furthermore, dioscin inhibited the phosphorylation of STAT3 and Src (an upstream kinase of STAT3), and downregulated mRNA levels of STAT3-targeted genes, including B-cell lymphoma-2, cyclin D1 and matrix metalloproteinase-2.	dioscin	13-20	signal transducer and activator of transcription 3	Mus musculus	54-59
32194752-8	2020	Furthermore, dioscin inhibited the phosphorylation of STAT3 and Src (an upstream kinase of STAT3), and downregulated mRNA levels of STAT3-targeted genes, including B-cell lymphoma-2, cyclin D1 and matrix metalloproteinase-2.	dioscin	13-20	signal transducer and activator of transcription 3	Mus musculus	91-96
32194752-8	2020	Furthermore, dioscin inhibited the phosphorylation of STAT3 and Src (an upstream kinase of STAT3), and downregulated mRNA levels of STAT3-targeted genes, including B-cell lymphoma-2, cyclin D1 and matrix metalloproteinase-2.	dioscin	13-20	signal transducer and activator of transcription 3	Mus musculus	91-96
32194752-9	2020	In addition, overexpression of STAT3 decreased the anti-proliferative effects of dioscin.	dioscin	81-88	signal transducer and activator of transcription 3	Mus musculus	31-36
32194752-10	2020	Overall, the results of the present study indicate that inhibiting the Src/STAT3 signaling pathway contributes to the anti-melanoma molecular mechanisms of dioscin.	dioscin	156-163	signal transducer and activator of transcription 3	Mus musculus	75-80
31999977-0	2020	Chrysoeriol ameliorates TPA-induced acute skin inflammation in mice and inhibits NF-kappaB and STAT3 pathways.	chrysoeriol	0-11	signal transducer and activator of transcription 3	Mus musculus	95-100
31999977-12	2020	The compound lowered protein levels of phospho-p65 (Ser536), phospho-STAT3 (Tyr705), inducible nitric oxide synthases (iNOS), cyclooxygenase-2 (COX-2), interleukin 6 (IL-6), IL-1beta and tumor necrosis factor alpha (TNF-alpha) in mouse swollen ears.	phosphorylleucylphenylalanine	61-68	signal transducer and activator of transcription 3	Mus musculus	69-74
32004989-3	2020	PURPOSE: In this work, we investigated the anticancer potential of convallatoxin and explored whether convallatoxin mediates its effect through interference with the STAT3 activation in colorectal cancer cells.	convallatoxin	102-115	signal transducer and activator of transcription 3	Mus musculus	166-171
32004989-4	2020	METHODS: In vitro, the underlying mechanisms of convallatoxin at inhibiting STAT3 activation were investigated by homology modeling and molecular docking, luciferase reporter assay, MTT assay, RT-PCR, Western blotting and immunofluorescence assays.	convallatoxin	48-61	signal transducer and activator of transcription 3	Mus musculus	76-81
31999977-14	2020	In addition, chrysoeriol decreased the production of NO and prostaglandin E2; inhibited the phosphorylation of inhibitor of kappaB (Ser32), p65 (Ser536) and Janus kinase 2 (Tyr1007/1008); decreased nuclear localization of p50, p65 and STAT3; and down-regulated mRNA levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha that are transcriptionally regulated by NF-kappaB and STAT3 in the cell model.	chrysoeriol	13-24	signal transducer and activator of transcription 3	Mus musculus	235-240
32004989-8	2020	Moreover, convallatoxin reduced the P-STAT3 (T705) via the JAK1, JAK2, and Src pathways and inhibited serine-727 phosphorylation of STAT3 via the PI3K-AKT-mTOR-STAT3 pathways in colorectal cancer cells.	convallatoxin	10-23	signal transducer and activator of transcription 3	Mus musculus	38-43
32004989-8	2020	Moreover, convallatoxin reduced the P-STAT3 (T705) via the JAK1, JAK2, and Src pathways and inhibited serine-727 phosphorylation of STAT3 via the PI3K-AKT-mTOR-STAT3 pathways in colorectal cancer cells.	convallatoxin	10-23	signal transducer and activator of transcription 3	Mus musculus	132-137
31999977-14	2020	In addition, chrysoeriol decreased the production of NO and prostaglandin E2; inhibited the phosphorylation of inhibitor of kappaB (Ser32), p65 (Ser536) and Janus kinase 2 (Tyr1007/1008); decreased nuclear localization of p50, p65 and STAT3; and down-regulated mRNA levels of pro-inflammatory cytokines IL-6, IL-1beta and TNF-alpha that are transcriptionally regulated by NF-kappaB and STAT3 in the cell model.	chrysoeriol	13-24	signal transducer and activator of transcription 3	Mus musculus	386-391
32004989-8	2020	Moreover, convallatoxin reduced the P-STAT3 (T705) via the JAK1, JAK2, and Src pathways and inhibited serine-727 phosphorylation of STAT3 via the PI3K-AKT-mTOR-STAT3 pathways in colorectal cancer cells.	cholecystokinin C-terminal flanking peptide	102-108	signal transducer and activator of transcription 3	Mus musculus	132-137
32004989-9	2020	Interestingly, we discovered the crosstalk between mTOR and JAK2 in mTOR/STAT3 and JAK/STAT3 pathways, which collaboratively regulated STAT3 activation and convallatoxin play a role in it.	convallatoxin	156-169	signal transducer and activator of transcription 3	Mus musculus	73-78
32004989-9	2020	Interestingly, we discovered the crosstalk between mTOR and JAK2 in mTOR/STAT3 and JAK/STAT3 pathways, which collaboratively regulated STAT3 activation and convallatoxin play a role in it.	convallatoxin	156-169	signal transducer and activator of transcription 3	Mus musculus	87-92
32071300-12	2020	Taken together, our findings suggest that BP-1-102 inhibits vascular inflammation and AAA progression through decreasing JAK2/STAT3 and NF-kappaB activation and maintaining autophagy.	BP-1-102	42-50	signal transducer and activator of transcription 3	Mus musculus	126-131
32004989-9	2020	Interestingly, we discovered the crosstalk between mTOR and JAK2 in mTOR/STAT3 and JAK/STAT3 pathways, which collaboratively regulated STAT3 activation and convallatoxin play a role in it.	convallatoxin	156-169	signal transducer and activator of transcription 3	Mus musculus	87-92
32004989-13	2020	CONCLUSION: The result of the current study show that convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer cells and indicate that convallatoxin could be a valuable candidate for the development of colorectal cancer therapeutic.	convallatoxin	54-67	signal transducer and activator of transcription 3	Mus musculus	162-167
32004989-13	2020	CONCLUSION: The result of the current study show that convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2/STAT3 (T705) and mTOR/STAT3 (S727) signaling pathways in colorectal cancer cells and indicate that convallatoxin could be a valuable candidate for the development of colorectal cancer therapeutic.	convallatoxin	54-67	signal transducer and activator of transcription 3	Mus musculus	184-189
32071300-2	2020	BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-kappaB, as well as regulate autophagy.	BP-1-102	0-8	signal transducer and activator of transcription 3	Mus musculus	25-30
32071300-2	2020	BP-1-102, a novel potent STAT3 inhibitor, has been recently reported to significantly block inflammation-related signaling pathways of JAK2/STAT3 and NF-kappaB, as well as regulate autophagy.	BP-1-102	0-8	signal transducer and activator of transcription 3	Mus musculus	140-145
32071300-9	2020	Moreover, BP-1-102 dramatically reduced the expression of JAK2, p-STAT3, p-NF-kappaB, and Bcl-xL but maintained the expression of LC3B and Beclin in AAA tissues.	BP-1-102	10-18	signal transducer and activator of transcription 3	Mus musculus	66-71
32071300-11	2020	BP-1-102 inhibited AngII-induced JAK2/STAT3 and NF-kappaB signaling activation and maintained autophagy-related proteins expression in VSMCs.	BP-1-102	0-8	signal transducer and activator of transcription 3	Mus musculus	38-43
32059373-7	2020	Furthermore, the treatment of oocytes with the Stat3-specific inhibitors stattic and BP-1-102 or anti-pStat3 antibody led to significantly abnormal spindle assembly and chromosome mislocation in a dose-dependent manner, and pStat3 was either absent or improperly localized in these oocytes.	BP-1-102	85-93	signal transducer and activator of transcription 3	Mus musculus	47-52
31866410-8	2020	The effect of AUDA on airway remodeling was related to the downregulation of extracellular-regulated protein kinases (Erk1/2), c-Jun N-terminal kinases (JNK) and signal transducer and activator of transcription 3 (STAT3).	12-(3-adamantan-1-ylureido)dodecanoic acid	14-18	signal transducer and activator of transcription 3	Mus musculus	162-212
31866410-8	2020	The effect of AUDA on airway remodeling was related to the downregulation of extracellular-regulated protein kinases (Erk1/2), c-Jun N-terminal kinases (JNK) and signal transducer and activator of transcription 3 (STAT3).	12-(3-adamantan-1-ylureido)dodecanoic acid	14-18	signal transducer and activator of transcription 3	Mus musculus	214-219
32024285-0	2020	High-Fat Diet Propelled AOM/DSS-Induced Colitis-Associated Colon Cancer Alleviated by Administration of Aster glehni via STAT3 Signaling Pathway.	Azoxymethane	24-27	signal transducer and activator of transcription 3	Mus musculus	121-126
31786468-6	2020	Moreover, puerarin inhibited the phosphorylation of p38 and ERK mitogen-activated protein kinases (MAPKs) and signal transducer and activator of transcription 3 (STAT3), thereby protecting the retinal cells from apoptosis by suppressing cytochrome c release, caspase activation, and poly (ADP-ribose) polymerase cleavage in vivo.	puerarin	10-18	signal transducer and activator of transcription 3	Mus musculus	110-160
31786468-6	2020	Moreover, puerarin inhibited the phosphorylation of p38 and ERK mitogen-activated protein kinases (MAPKs) and signal transducer and activator of transcription 3 (STAT3), thereby protecting the retinal cells from apoptosis by suppressing cytochrome c release, caspase activation, and poly (ADP-ribose) polymerase cleavage in vivo.	puerarin	10-18	signal transducer and activator of transcription 3	Mus musculus	162-167
31786468-8	2020	The experimental data verify the protective role of puerarin in the treatment of retinal injury caused by iron overload; its possible mechanisms might be associated with regulation of iron-handling proteins, enhancement of the antioxidant capacity, and the inhibition of MAPK and STAT3 activation and the apoptotic pathways under iron overload conditions.	puerarin	52-60	signal transducer and activator of transcription 3	Mus musculus	280-285
31692041-4	2020	Additionally, the Stat3 inhibitor nifuroxazide was employed to promote the antitumor activity.	nifuroxazide	34-46	signal transducer and activator of transcription 3	Mus musculus	18-23
32054021-6	2020	We next found that the PTPN2, Factor B, and VRK1 concentrations in silicotic rats silicosis and SiO2-stimulated MLE-12 cells were significantly higher than control groups.More importantly, we found that overexpression of PTPN2 simultaneously decreased the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) and Vimentin, while increasing E-cadherin expression.	Silicon Dioxide	96-100	signal transducer and activator of transcription 3	Mus musculus	278-328
32054021-6	2020	We next found that the PTPN2, Factor B, and VRK1 concentrations in silicotic rats silicosis and SiO2-stimulated MLE-12 cells were significantly higher than control groups.More importantly, we found that overexpression of PTPN2 simultaneously decreased the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) and Vimentin, while increasing E-cadherin expression.	Silicon Dioxide	96-100	signal transducer and activator of transcription 3	Mus musculus	332-337
32104542-0	2020	Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	117-122
32104542-5	2020	Metformin was able to reduce senescence by upregulating the expression of RNA-binding protein MBNL1 and miR-130a-3p and reducing STAT3 expression.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	129-134
32104542-8	2020	Meanwhile, metformin (200 mg/kg/day) could increase the expression of MBNL1 and miR-130a-3p and decreased STAT3 expression, thus reducing this senescence in db/db mice.	Metformin	11-20	signal transducer and activator of transcription 3	Mus musculus	106-111
32104542-9	2020	Our results suggest that metformin reduces the senescence of renal tubular epithelial cells in diabetic nephropathy via the MBNL1/miR-130a-3p/STAT3 pathway, which provided new ideas for the therapy of this disease.	Metformin	25-34	signal transducer and activator of transcription 3	Mus musculus	142-147
32042022-4	2020	The expression levels of phospho-Jak2, phospho-Stat3, integrin alphaV, and integrin beta5 were increased after cordycepin treatment.	phosphorylleucylphenylalanine	39-46	signal transducer and activator of transcription 3	Mus musculus	47-52
32042022-4	2020	The expression levels of phospho-Jak2, phospho-Stat3, integrin alphaV, and integrin beta5 were increased after cordycepin treatment.	cordycepin	111-121	signal transducer and activator of transcription 3	Mus musculus	47-52
32042022-9	2020	Taken together, we demonstrated that cordycepin maintained the pluripotency of stem cells via regulation of extracellular matrix (ECM) and Jak2/Stat3 signaling pathway and improved the generation efficiency of iPSCs.	cordycepin	37-47	signal transducer and activator of transcription 3	Mus musculus	144-149
31841386-8	2020	Daily intraperitoneal injection of high glucose-based dialysis fluid induced peritoneal fibrosis, angiogenesis, and macrophage infiltration in a mouse model, accompanied by phosphorylation of STAT3.	Glucose	40-47	signal transducer and activator of transcription 3	Mus musculus	192-197
31809801-3	2020	In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727.	R 111	13-21	signal transducer and activator of transcription 3	Mus musculus	108-113
31789102-0	2020	Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway.	Amino Acids	0-11	signal transducer and activator of transcription 3	Mus musculus	133-138
31789102-0	2020	Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway.	Vitamin E	16-25	signal transducer and activator of transcription 3	Mus musculus	133-138
31881477-7	2020	When the mechanism was investigated, dioscin was found to markedly elevate miR-125a-5p level and decrease STAT3 expression.	dioscin	37-44	signal transducer and activator of transcription 3	Mus musculus	106-111
31881477-8	2020	Consequently, dioscin increased phosphorylation levels of STAT3, PI3K, AKT, GSK-3beta, and FoxO1 and decreased gene levels of PEPCK, G6Pase, SREBP-1c, FAS, ACC, and SCD1, leading to an increase in glycogen synthesis and a decrease in gluconeogenesis and lipogenesis.	dioscin	14-21	signal transducer and activator of transcription 3	Mus musculus	58-63
31881477-9	2020	The effects of dioscin on regulating miR-125a-5p/STAT3 pathway were verified by miR-125a-5p overexpression and STAT3 overexpression.	dioscin	15-22	signal transducer and activator of transcription 3	Mus musculus	49-54
31881477-9	2020	The effects of dioscin on regulating miR-125a-5p/STAT3 pathway were verified by miR-125a-5p overexpression and STAT3 overexpression.	dioscin	15-22	signal transducer and activator of transcription 3	Mus musculus	111-116
31881477-10	2020	CONCLUSIONS: Dioscin showed potent anti-T2DM activity by improving the inhibitory effect of miR-125a-5p on STAT3 signaling to alleviate glycolipid metabolic disorder of T2DM.	dioscin	13-20	signal transducer and activator of transcription 3	Mus musculus	107-112
32023857-0	2020	A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion.	lactucin	36-44	signal transducer and activator of transcription 3	Mus musculus	98-103
32023857-11	2020	Further studies demonstrate that lactucin-induced MCE arrests might result from reduced phosphorylation of JAK2 and STAT3.	lactucin	33-41	signal transducer and activator of transcription 3	Mus musculus	116-121
32023857-12	2020	We then asked whether activation of JAK2/STAT3 would restore the inhibitory effect of lactucin on adipogenesis with pharmacological STAT3 activator colivelin.	lactucin	86-94	signal transducer and activator of transcription 3	Mus musculus	41-46
32023857-13	2020	Our results revealed similar levels of lipid accumulation between lactucin-treated cells and controls in the presence of colivelin, indicating that inactivation of STAT3 is the limiting factor for the anti-adipogenesis of lactucin in these cells.	lactucin	222-230	signal transducer and activator of transcription 3	Mus musculus	164-169
32038241-0	2019	Butyric Acid Increases the Therapeutic Effect of EHLJ7 on Ulcerative Colitis by Inhibiting JAK2/STAT3/SOCS1 Signaling Pathway.	Butyric Acid	0-12	signal transducer and activator of transcription 3	Mus musculus	96-101
31770044-8	2020	Because the synthesis of PGE2 is catalyzed by COX-2 and phosphorylation of STAT3 can induce the expression of COX-2, it was concluded that STAT3 was a key protein related to the POLP exerting its activity in colitis.	Dinoprostone	25-29	signal transducer and activator of transcription 3	Mus musculus	75-80
31770044-8	2020	Because the synthesis of PGE2 is catalyzed by COX-2 and phosphorylation of STAT3 can induce the expression of COX-2, it was concluded that STAT3 was a key protein related to the POLP exerting its activity in colitis.	Dinoprostone	25-29	signal transducer and activator of transcription 3	Mus musculus	139-144
32038231-16	2019	Conclusion: ATLIII has shown significant efficacy to inhibit IFN-gamma-triggered Jak3/Stat3 pathway-dependent IDO activation, and do so through a direct binding to Jak3 protein.	atractylenolide III	12-18	signal transducer and activator of transcription 3	Mus musculus	86-91
31784187-2	2020	STAT3-targeted therapeutics are reported to show efficacy in melanomas harboring the BRAFV600E mutant and also in vemurafenib-resistant melanomas.	vemurafenib	114-125	signal transducer and activator of transcription 3	Mus musculus	0-5
31784187-3	2020	We designed and synthesized a series of substituted nitric oxide (NO)-releasing quinolone-1,2,4-triazole/oxime hybrids, hypothesizing that the introduction of a STAT3 binding scaffold would augment their cytotoxicity.	Nitric Oxide	52-64	signal transducer and activator of transcription 3	Mus musculus	161-166
31784187-3	2020	We designed and synthesized a series of substituted nitric oxide (NO)-releasing quinolone-1,2,4-triazole/oxime hybrids, hypothesizing that the introduction of a STAT3 binding scaffold would augment their cytotoxicity.	carbostyril	80-104	signal transducer and activator of transcription 3	Mus musculus	161-166
31784187-3	2020	We designed and synthesized a series of substituted nitric oxide (NO)-releasing quinolone-1,2,4-triazole/oxime hybrids, hypothesizing that the introduction of a STAT3 binding scaffold would augment their cytotoxicity.	Oximes	105-110	signal transducer and activator of transcription 3	Mus musculus	161-166
31784187-6	2020	Also, they abrogated STAT3 tyrosine phosphorylation in several cancer cell lines, including the A375 melanoma cell line that carries the BRAFV600E mutation.	Tyrosine	27-35	signal transducer and activator of transcription 3	Mus musculus	21-26
31843524-0	2020	The JAK2/STAT3 pathway is involved in the anti-melanoma effects of brevilin A.	brevilin A	67-77	signal transducer and activator of transcription 3	Mus musculus	9-14
31843524-7	2020	KEY FINDINGS: Intraperitoneal injection of brevilin A dose-dependently inhibited melanoma growth in mice and suppressed STAT3 phosphorylation in the tumors.	brevilin A	43-53	signal transducer and activator of transcription 3	Mus musculus	120-125
31843524-8	2020	In cultured cells, brevilin A reduced cell viability, induced apoptosis, suppressed migration and invasion, decreased protein levels of phospho-JAK2 (Y1007/1008) and phospho-STAT3 (Tyr705), and restrained STAT3 nuclear localization.	brevilin A	19-29	signal transducer and activator of transcription 3	Mus musculus	174-179
31843524-8	2020	In cultured cells, brevilin A reduced cell viability, induced apoptosis, suppressed migration and invasion, decreased protein levels of phospho-JAK2 (Y1007/1008) and phospho-STAT3 (Tyr705), and restrained STAT3 nuclear localization.	brevilin A	19-29	signal transducer and activator of transcription 3	Mus musculus	205-210
31843524-9	2020	STAT3 over-activation diminished brevilin A"s effects on cell viability and migration.	brevilin	33-41	signal transducer and activator of transcription 3	Mus musculus	0-5
31843524-10	2020	Collectively, brevilin A exerts anti-melanoma effects and these effects are at least in part attributed to the inhibition of the JAK2/STAT3 pathway.	brevilin A	14-24	signal transducer and activator of transcription 3	Mus musculus	134-139
31812773-11	2020	Finally, verteporfin exhibited an anti-inflammation effect by crosslinking of protein such as NF-kappaB p65, JAK1, JAK2, STAT1, or STAT3 leading to inflammation.	verteporfin	9-20	signal transducer and activator of transcription 3	Mus musculus	131-136
31934850-8	2020	Finally, STAT3 inhibitor S3I-201 or AAV9 carrying a periostin promoter driving the expression of shRNA targeting Stat3 significantly attenuated the synergistic effects of IH and Ang II on cardiac fibrosis in mice.	8,2'-S-cycloinosinyl-(3',5')-8,2'-S-cycloadenosine	25-28	signal transducer and activator of transcription 3	Mus musculus	9-14
31931878-0	2020	Mesenchymal stem cells alleviate liver injury induced by chronic-binge ethanol feeding in mice via release of TSG6 and suppression of STAT3 activation.	Ethanol	71-78	signal transducer and activator of transcription 3	Mus musculus	134-139
31931878-11	2020	The signal transducer and activator of transcription 3 (STAT3) was activated in mice with AH, and MSCs and rmTSG-6 inhibited the STAT3 activation.	rmtsg-6	107-114	signal transducer and activator of transcription 3	Mus musculus	4-54
31931878-11	2020	The signal transducer and activator of transcription 3 (STAT3) was activated in mice with AH, and MSCs and rmTSG-6 inhibited the STAT3 activation.	rmtsg-6	107-114	signal transducer and activator of transcription 3	Mus musculus	56-61
31931878-11	2020	The signal transducer and activator of transcription 3 (STAT3) was activated in mice with AH, and MSCs and rmTSG-6 inhibited the STAT3 activation.	rmtsg-6	107-114	signal transducer and activator of transcription 3	Mus musculus	129-134
32009856-14	2020	Primary miR-21 was found to be notable raised by Si-STAT3, while the converse effect was seen in mature miR-21 expressions.	Silicon	49-51	signal transducer and activator of transcription 3	Mus musculus	52-57
32038231-0	2019	The Anticancer Effects of Atractylenolide III Associate With the Downregulation of Jak3/Stat3-Dependent IDO Expression.	atractylenolide III	26-45	signal transducer and activator of transcription 3	Mus musculus	88-93
32038231-3	2019	This study is to determine the anticancer effects of ATLIII with the Jak3/Stat3-dependent IDO inactivation.	atractylenolide III	53-59	signal transducer and activator of transcription 3	Mus musculus	74-79
32038231-6	2019	We also determined the efficacy of ATLIII on Jak3/Stat3 pathway expression induced by IFN-gamma and Jak3/Stat3-dependent IDO activation.	atractylenolide III	35-41	signal transducer and activator of transcription 3	Mus musculus	50-55
32038231-11	2019	ATLIII reduced the phosphorylation level of Jak3 and Stat3 in response to IFN-gamma stimulation, then remarkably reduced the nuclear translocation of p-Stat3 by IFN-gamma.	atractylenolide III	0-6	signal transducer and activator of transcription 3	Mus musculus	53-58
32038241-8	2019	Further study indicated that EHLJ7 could cooperate with butyrate to exert its anti-ulcerative colitis effect by inhibiting the activation of janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 1 (SOCS1) pathway.	Butyrates	56-64	signal transducer and activator of transcription 3	Mus musculus	163-213
32038241-8	2019	Further study indicated that EHLJ7 could cooperate with butyrate to exert its anti-ulcerative colitis effect by inhibiting the activation of janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/suppressor of cytokine signaling 1 (SOCS1) pathway.	Butyrates	56-64	signal transducer and activator of transcription 3	Mus musculus	215-220
31935860-5	2020	Db-cAMP also showed a synergistic effect with IL-4 in inducing STAT-3 phosphorylation and Arg-1 expression.	Bucladesine	0-7	signal transducer and activator of transcription 3	Mus musculus	63-69
31947933-6	2020	In addition, vaccination with Stat3 /  CD103+ cDC1s elicited increased amounts of tumor antigen-specific CD8+ T cells and IFN-gamma+ CD4+ T cells in tumors and tumor-draining lymph nodes versus phosphate-buffered saline (PBS)-treated animals.	Phosphates	194-203	signal transducer and activator of transcription 3	Mus musculus	30-35
31896157-0	2021	Luteolin Attenuates Diabetic Nephropathy through Suppressing Inflammatory Response and Oxidative Stress by Inhibiting STAT3 Pathway.	Luteolin	0-8	signal transducer and activator of transcription 3	Mus musculus	118-123
31938906-0	2020	Specific Roles of JAKs and STAT3 in Functions of Neural Stem Cells and Committed Neuronal Progenitors during Ethanol-Induced Neurodegeneration.	Ethanol	109-116	signal transducer and activator of transcription 3	Mus musculus	27-32
31938906-4	2020	A long-term in vivo exposure of mice to ethanol inversed the roles of JAKs and STAT3 in determination of proliferative status of neural stem cells and eliminated involvement of JAKs in functional control over the committed progenitors of neurons.	Ethanol	40-47	signal transducer and activator of transcription 3	Mus musculus	79-84
31938906-5	2020	The data attest to much promise of STAT3 inhibitors in treatment of ethanol-induced CNS diseases as the remedies that stimulate realization of growth potential in multipotent neural stem cells and committed neural progenitors.	Ethanol	68-75	signal transducer and activator of transcription 3	Mus musculus	35-40
31802182-0	2020	IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4 axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment.	Fatty Acids	16-26	signal transducer and activator of transcription 3	Mus musculus	63-68
31802182-4	2020	We found that in the presence of palmitic acid (PA), IL-17A could directly increase the cellular uptake of PA, leading to the proliferation of OvCa cells via the IL-17A/IL-17RA/p-STAT3/FABP4 axis rather than via CD36.	Palmitic Acid	33-46	signal transducer and activator of transcription 3	Mus musculus	179-184
31802182-4	2020	We found that in the presence of palmitic acid (PA), IL-17A could directly increase the cellular uptake of PA, leading to the proliferation of OvCa cells via the IL-17A/IL-17RA/p-STAT3/FABP4 axis rather than via CD36.	Palmitic Acid	48-50	signal transducer and activator of transcription 3	Mus musculus	179-184
31802182-4	2020	We found that in the presence of palmitic acid (PA), IL-17A could directly increase the cellular uptake of PA, leading to the proliferation of OvCa cells via the IL-17A/IL-17RA/p-STAT3/FABP4 axis rather than via CD36.	Palmitic Acid	107-109	signal transducer and activator of transcription 3	Mus musculus	179-184
31929748-10	2020	Mechanistically, Ruxolitinib treatment attenuated activation of both Stat3 and Akt/mTOR/Yap pathways.	ruxolitinib	17-28	signal transducer and activator of transcription 3	Mus musculus	69-74
31097787-4	2020	By knocking out STAT3 specifically in mouse beta-cells, we found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia.	Streptozocin	126-129	signal transducer and activator of transcription 3	Mus musculus	16-21
31097787-4	2020	By knocking out STAT3 specifically in mouse beta-cells, we found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia.	Streptozocin	126-129	signal transducer and activator of transcription 3	Mus musculus	82-87
31689559-9	2020	WTE+Alcohol-induced polyposis was associated with increased STAT3 expression.	Ethanol	4-11	signal transducer and activator of transcription 3	Mus musculus	60-65
31689559-10	2020	Decreased butyrate signaling activated epithelial STAT3 in vitro.	Butyrates	10-18	signal transducer and activator of transcription 3	Mus musculus	50-55
31908570-5	2020	A single dose administration of imatinib (20 and 40 mg/kg) attenuated ischemia-reperfusion-induced behavioral deficits and the extent of cerebral infarction along with the restoration of connexin 43 and p-STAT3 levels.	imatinib	32-40	signal transducer and activator of transcription 3	Mus musculus	205-210
31433913-2	2020	Recent studies show that niclosamide exerts antitumor activity through inhibiting multiple signals including Wnt/beta-catenin, mTORC1, signal transducer and activator of transcription 3, NF-kappaB, notch signals; however, the insolubility and poor bioavailability limits its potential clinic use, the aim of the present work is to synthesize an injectable pegylated niclosamide (polyethylene glycol-modified niclosamide) and investigate its antitumor activity in vitro and in vivo.	Niclosamide	25-36	signal transducer and activator of transcription 3	Mus musculus	135-185
31821710-7	2020	In accordance with these findings, amlexanox treatment suppressed HSC activation and its related fibrogenic responses by partially inhibiting signal transducer and activator of transcription 3.	amlexanox	35-44	signal transducer and activator of transcription 3	Mus musculus	142-192
31866378-8	2020	Doxorubicin induced FOXO1 binding to STAT3 and prevented STAT3 from interacting with Sp1.	Doxorubicin	0-11	signal transducer and activator of transcription 3	Mus musculus	37-42
31866378-8	2020	Doxorubicin induced FOXO1 binding to STAT3 and prevented STAT3 from interacting with Sp1.	Doxorubicin	0-11	signal transducer and activator of transcription 3	Mus musculus	57-62
31866378-9	2020	However, atorvastatin inhibited these interactions and stabilized STAT3/Sp1 transcription complex.	atorvastatin	9-21	signal transducer and activator of transcription 3	Mus musculus	66-71
31866378-10	2020	Chromatin immunoprecipitation analysis demonstrated that doxorubicin decreased STAT3/Sp1 complex binding to survivin promoter, whereas atorvastatin stabilized this binding.	Doxorubicin	57-68	signal transducer and activator of transcription 3	Mus musculus	79-84
31866378-12	2020	CONCLUSIONS: Our study suggested a new pathophysiologic mechanism that survivin mediated protective effect of atorvastatin against doxorubicin-induced cardiotoxicity via FOXO1/STAT3/Sp1 transcriptional network.	atorvastatin	110-122	signal transducer and activator of transcription 3	Mus musculus	176-181
31866378-12	2020	CONCLUSIONS: Our study suggested a new pathophysiologic mechanism that survivin mediated protective effect of atorvastatin against doxorubicin-induced cardiotoxicity via FOXO1/STAT3/Sp1 transcriptional network.	Doxorubicin	131-142	signal transducer and activator of transcription 3	Mus musculus	176-181
31908570-6	2020	However, administration of AG490, a selective Janus-activated kinase 2 (JAK2)/STAT3 inhibitor, abolished the neuroprotective actions of imatinib and decreased the expression of connexin 43 and p-STAT3.	imatinib	136-144	signal transducer and activator of transcription 3	Mus musculus	78-83
31908570-7	2020	It is concluded that imatinib has the potential of attenuating global ischemia-reperfusion-induced cerebral injury, which may be possibly attributed to activation of JAK2/STAT3 signaling pathway along with the increase in the expression of connexin 43.	imatinib	21-29	signal transducer and activator of transcription 3	Mus musculus	171-176
31614297-7	2019	Local accumulation of Th17 cells and enhanced phosphorylation of STAT3 were also seen in the impaired kidney in TCE sensitization-positive mice.	Trichloroethylene	112-115	signal transducer and activator of transcription 3	Mus musculus	65-70
31712941-1	2020	Calycosin-7-O-beta-D-glucoside (CG) is the component of Astragali Radix, and the aim of the present study is to investigate whether CG protects myocardium from I/R-induced damage by the regulation of IL-10/JAK2/STAT3 signaling pathway.	calycosin-7-O-beta-D-glucoside	32-34	signal transducer and activator of transcription 3	Mus musculus	211-216
31712941-4	2020	In vitro and in vivo results showed that CG up-regulated IL-10 level, activated the JAK2/STAT3 pathway, and protected myocardial cells from I/R-induced apoptosis.	calycosin-7-O-beta-D-glucoside	41-43	signal transducer and activator of transcription 3	Mus musculus	89-94
31712941-6	2020	CG-induced phosphorylation activation of JAK2/STAT3 signaling pathway was also suppressed by the blocking of IL-10.	calycosin-7-O-beta-D-glucoside	0-2	signal transducer and activator of transcription 3	Mus musculus	46-51
31712941-7	2020	In summary, these findings suggest that CG might alleviate myocardial I/R injury by activating the JAK2/STAT3 signaling pathway via up-regulation of IL-10 secretion, which provides us insights into the mechanism underlying the protective effect of CG on myocardial I/R injury.	calycosin-7-O-beta-D-glucoside	40-42	signal transducer and activator of transcription 3	Mus musculus	104-109
31614297-10	2019	Together, our results demonstrate that C3aR signaling promotes the inflammatory responses and regulates the accumulation of Th17 phenotype via phosphorylation of STAT3 in TCE sensitization induced inflammatory kidney damage.	Trichloroethylene	171-174	signal transducer and activator of transcription 3	Mus musculus	162-167
31712309-0	2019	BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways.	bmp10	0-5	signal transducer and activator of transcription 3	Mus musculus	82-87
31712309-7	2019	Gene profiling and biochemical analyses indicated that BMP10 activates the SMAD-mediated canonical pathway and, unexpectedly, also the signal transducer and activator of transcription 3 (STAT3)-mediated signaling pathway both in vivo and in vitro Additional findings further supported the notion that BMP10"s cardioprotective function likely is due to its dual activation of SMAD- and STAT3-regulated signaling pathways, promoting cardiomyocyte survival and suppressing cardiac fibrosis.	bmp10	55-60	signal transducer and activator of transcription 3	Mus musculus	187-192
31712309-7	2019	Gene profiling and biochemical analyses indicated that BMP10 activates the SMAD-mediated canonical pathway and, unexpectedly, also the signal transducer and activator of transcription 3 (STAT3)-mediated signaling pathway both in vivo and in vitro Additional findings further supported the notion that BMP10"s cardioprotective function likely is due to its dual activation of SMAD- and STAT3-regulated signaling pathways, promoting cardiomyocyte survival and suppressing cardiac fibrosis.	bmp10	55-60	signal transducer and activator of transcription 3	Mus musculus	385-390
31712309-7	2019	Gene profiling and biochemical analyses indicated that BMP10 activates the SMAD-mediated canonical pathway and, unexpectedly, also the signal transducer and activator of transcription 3 (STAT3)-mediated signaling pathway both in vivo and in vitro Additional findings further supported the notion that BMP10"s cardioprotective function likely is due to its dual activation of SMAD- and STAT3-regulated signaling pathways, promoting cardiomyocyte survival and suppressing cardiac fibrosis.	bmp10	301-306	signal transducer and activator of transcription 3	Mus musculus	135-185
31712309-7	2019	Gene profiling and biochemical analyses indicated that BMP10 activates the SMAD-mediated canonical pathway and, unexpectedly, also the signal transducer and activator of transcription 3 (STAT3)-mediated signaling pathway both in vivo and in vitro Additional findings further supported the notion that BMP10"s cardioprotective function likely is due to its dual activation of SMAD- and STAT3-regulated signaling pathways, promoting cardiomyocyte survival and suppressing cardiac fibrosis.	bmp10	301-306	signal transducer and activator of transcription 3	Mus musculus	187-192
31747516-4	2019	We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain.	CHEMBL4575382	18-24	signal transducer and activator of transcription 3	Mus musculus	70-75
31747516-8	2019	A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues.	CHEMBL4452527	17-22	signal transducer and activator of transcription 3	Mus musculus	43-48
31747516-10	2019	SD-36 is a potent, selective, and efficacious STAT3 degrader.	CHEMBL4452527	0-5	signal transducer and activator of transcription 3	Mus musculus	46-51
31846485-6	2019	Cytokine production, inflammation, and interstitial fibrosis were analyzed in obstructed and sham operated kidneys of neonatal mice treated with or without JAK2/STAT3 inhibitor Tyrphostin AG490.	Tyrphostins	177-187	signal transducer and activator of transcription 3	Mus musculus	161-166
31885784-8	2019	Meanwhile, genipin attenuated CCl4-induced inflammatory response by inhibiting the NF-kappaB and STAT3 signaling pathway.	genipin	11-18	signal transducer and activator of transcription 3	Mus musculus	97-102
30994173-0	2019	Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation.	phospho-valproic acid	0-21	signal transducer and activator of transcription 3	Mus musculus	112-117
31816985-8	2019	Notably, intraperitoneal administration of TMS-TMF-4f (5, 10, or 20 mg/kg) decreased tumor growth in a xenograft cervical cancer mouse model, demonstrated by the increase in TUNEL staining and PARP cleavage and the reduction in p-STAT3, Mcl-1, cyclin D1, survivin, and c-Myc expression levels in tumor tissues.	thiomarinol F	43-53	signal transducer and activator of transcription 3	Mus musculus	230-235
31827540-12	2019	Immunohistochemistry results showed that CoCl2 treatment enhanced Hif-1alpha, ALP and pSTAT3 expression in cells present in the bone defect area and that inhibiting STAT3 reduced this effect.	cobaltous chloride	41-46	signal transducer and activator of transcription 3	Mus musculus	87-92
31654627-3	2019	In the present study, we found that low-dose methotrexate significantly induced apoptosis in transformed Ba/F3 cells expressing NPM-ALK by inhibiting the activation of signal transducer and activator of transcription factor 3 (STAT3), a critical downstream molecule of NPM-ALK.	Methotrexate	45-57	signal transducer and activator of transcription 3	Mus musculus	168-225
31654627-3	2019	In the present study, we found that low-dose methotrexate significantly induced apoptosis in transformed Ba/F3 cells expressing NPM-ALK by inhibiting the activation of signal transducer and activator of transcription factor 3 (STAT3), a critical downstream molecule of NPM-ALK.	Methotrexate	45-57	signal transducer and activator of transcription 3	Mus musculus	227-232
31654627-4	2019	Although methotrexate prevented the phosphorylation of STAT3, it did not affect the activity of NPM-ALK.	Methotrexate	9-21	signal transducer and activator of transcription 3	Mus musculus	55-60
31654627-5	2019	A co-treatment with folinic acid prevented the methotrexate-induced inhibition of STAT3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (THF) in transformed cells by NPM-ALK.	Leucovorin	20-32	signal transducer and activator of transcription 3	Mus musculus	82-87
31654627-5	2019	A co-treatment with folinic acid prevented the methotrexate-induced inhibition of STAT3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (THF) in transformed cells by NPM-ALK.	Methotrexate	47-59	signal transducer and activator of transcription 3	Mus musculus	82-87
31654627-5	2019	A co-treatment with folinic acid prevented the methotrexate-induced inhibition of STAT3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (THF) in transformed cells by NPM-ALK.	Methotrexate	143-155	signal transducer and activator of transcription 3	Mus musculus	82-87
31654627-5	2019	A co-treatment with folinic acid prevented the methotrexate-induced inhibition of STAT3 activation and induction of apoptosis, suggesting that methotrexate exerts its cytotoxic effects by depleting tetrahydrofolate (THF) in transformed cells by NPM-ALK.	5,6,7,8-tetrahydrofolic acid	198-214	signal transducer and activator of transcription 3	Mus musculus	82-87
31654627-6	2019	Furthermore, methotrexate induced the down-regulation of the anti-apoptotic protein, MCL-1, DNA damage, and the activation of a p53 tumor suppressor, leading to apoptosis through the inhibition of STAT3.	Methotrexate	13-25	signal transducer and activator of transcription 3	Mus musculus	197-202
31550676-6	2019	In additionally, metformin could enhance the phosphorylation of AMPK, reduce STAT3 phosphorylation levels, and down-regulate the inhibitory function of G-MDSCs in vitro.	Metformin	17-26	signal transducer and activator of transcription 3	Mus musculus	77-82
30994173-0	2019	Phospho-valproic acid (MDC-1112) suppresses glioblastoma growth in preclinical models through the inhibition of STAT3 phosphorylation.	MDC-1112	23-31	signal transducer and activator of transcription 3	Mus musculus	112-117
30994173-3	2019	We have documented previously that phospho-valproic acid (MDC-1112), which inhibits STAT3 activation, possesses strong anticancer properties in multiple cancer types.	phospho-valproic acid	35-56	signal transducer and activator of transcription 3	Mus musculus	84-89
30994173-3	2019	We have documented previously that phospho-valproic acid (MDC-1112), which inhibits STAT3 activation, possesses strong anticancer properties in multiple cancer types.	MDC-1112	58-66	signal transducer and activator of transcription 3	Mus musculus	84-89
30994173-10	2019	Mechanistically, MDC-1112 inhibited STAT3 phosphorylation at the serine 727 residue, but not at tyrosine 705, in vitro and in vivo.	MDC-1112	17-25	signal transducer and activator of transcription 3	Mus musculus	36-41
31885784-8	2019	Meanwhile, genipin attenuated CCl4-induced inflammatory response by inhibiting the NF-kappaB and STAT3 signaling pathway.	Carbon Tetrachloride	30-34	signal transducer and activator of transcription 3	Mus musculus	97-102
31793209-0	2019	Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway.	Melatonin	0-9	signal transducer and activator of transcription 3	Mus musculus	134-139
30994173-10	2019	Mechanistically, MDC-1112 inhibited STAT3 phosphorylation at the serine 727 residue, but not at tyrosine 705, in vitro and in vivo.	Serine	65-71	signal transducer and activator of transcription 3	Mus musculus	36-41
30994173-11	2019	STAT3 overexpression rescued GBM cells from the cell growth inhibition by MDC-1112.	MDC-1112	74-82	signal transducer and activator of transcription 3	Mus musculus	0-5
30994173-12	2019	In addition, MDC-1112 reduced STAT3 levels in the mitochondria and enhanced mitochondrial levels of reactive oxygen species, which triggered apoptosis.	MDC-1112	13-21	signal transducer and activator of transcription 3	Mus musculus	30-35
30994173-13	2019	In conclusion, MDC-1112 displays strong efficacy in preclinical models of GBM, with the serine 727 residue of STAT3 being its key molecular target.	MDC-1112	15-23	signal transducer and activator of transcription 3	Mus musculus	110-115
30994173-13	2019	In conclusion, MDC-1112 displays strong efficacy in preclinical models of GBM, with the serine 727 residue of STAT3 being its key molecular target.	Serine	88-94	signal transducer and activator of transcription 3	Mus musculus	110-115
30994173-16	2019	The novel agent MDC-1112 is an effective anticancer agent in multiple animal models of glioblastoma, and its mechanism of action involves the inhibition of STAT3 phosphorylation, primarily at its Serine 727 residue.	MDC-1112	16-24	signal transducer and activator of transcription 3	Mus musculus	156-161
30994173-16	2019	The novel agent MDC-1112 is an effective anticancer agent in multiple animal models of glioblastoma, and its mechanism of action involves the inhibition of STAT3 phosphorylation, primarily at its Serine 727 residue.	Serine	196-202	signal transducer and activator of transcription 3	Mus musculus	156-161
31585206-0	2019	Hydrogen peroxide modulates clock gene expression via PRX2-STAT3-REV-ERBalpha/beta pathway.	Hydrogen Peroxide	0-17	signal transducer and activator of transcription 3	Mus musculus	59-64
31793209-15	2019	STAT3 blockade significantly reduced the effect of melatonin on microglial phenotype shift.	Melatonin	51-60	signal transducer and activator of transcription 3	Mus musculus	0-5
31585206-7	2019	Further studies showed that H2O2 regulated biological rhythm by PRX2-STAT3-REV-ERBalpha/beta pathway.	Water	28-32	signal transducer and activator of transcription 3	Mus musculus	69-74
31793209-16	2019	CONCLUSION: Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner.	Melatonin	12-21	signal transducer and activator of transcription 3	Mus musculus	170-175
31321583-7	2019	In addition, the LPS-induced phosphorylation of key proteins of NF-kappaB/MAPK/STAT3 pathways in RAW264.7 macrophages, such as p65, IkappaB-alpha, Erk1/2, JNK, and STAT3 proteins, could be inhibited by AZD4547 pretreatment.	AZD4547	202-209	signal transducer and activator of transcription 3	Mus musculus	79-84
31626919-9	2019	Mechanistically, miR-124 directly targeted signal transducer and activator of transcription 3 (STAT3) in BV2 cells; in addition, upregulation of miR-124 inhibited the increase of inducible nitric oxide synthetase and proinflammatory cytokines, including IL-6, IL-1beta, TNF-alpha, and MCP-1, in LPS-stimulated BV2 cells.	Nitric Oxide	189-201	signal transducer and activator of transcription 3	Mus musculus	43-93
30863843-16	2019	CONCLUSION: We propose that STAT3 inhibition is a viable and potent therapeutic target against Tregs.	tregs	95-100	signal transducer and activator of transcription 3	Mus musculus	28-33
31626919-9	2019	Mechanistically, miR-124 directly targeted signal transducer and activator of transcription 3 (STAT3) in BV2 cells; in addition, upregulation of miR-124 inhibited the increase of inducible nitric oxide synthetase and proinflammatory cytokines, including IL-6, IL-1beta, TNF-alpha, and MCP-1, in LPS-stimulated BV2 cells.	Nitric Oxide	189-201	signal transducer and activator of transcription 3	Mus musculus	95-100
31627175-6	2019	The binding of STAT3 inhibitors and NAC was analyzed by LC-MS.	Acetylcysteine	36-39	signal transducer and activator of transcription 3	Mus musculus	15-20
31728857-8	2019	Further experiments verified that PF pretreatment alleviated H2O2-induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways.	peoniflorin	34-36	signal transducer and activator of transcription 3	Mus musculus	197-202
31728857-8	2019	Further experiments verified that PF pretreatment alleviated H2O2-induced oxidative stress through increasing cell viability, inhibiting cell apoptosis, reducing ROS generation and activating JAK2/STAT3 and ERK1/2 pathways.	Water	61-65	signal transducer and activator of transcription 3	Mus musculus	197-202
31728857-11	2019	These results indicated that PF can alleviate H2O2-induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.	peoniflorin	29-31	signal transducer and activator of transcription 3	Mus musculus	130-135
31728857-11	2019	These results indicated that PF can alleviate H2O2-induced oxidative stress by down-regulation of miR-135a via activation of JAK2/STAT3 and ERK1/2 pathways.	Water	46-50	signal transducer and activator of transcription 3	Mus musculus	130-135
31627175-0	2019	N-Acetyl cysteine prevents activities of STAT3 inhibitors, Stattic and BP-1-102 independently of its antioxidant properties.	Acetylcysteine	0-17	signal transducer and activator of transcription 3	Mus musculus	41-46
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	Acetylcysteine	13-16	signal transducer and activator of transcription 3	Mus musculus	83-88
31627175-2	2019	We found that the antioxidant reagent, N-acetyl cysteine (NAC) prevented the abilities of Stattic and BP-1-102, but not LLL12 to induce apoptosis in transformed cells expressing NPM-ALK, providing a novel problem in use of STAT3 inhibitors.	Acetylcysteine	39-56	signal transducer and activator of transcription 3	Mus musculus	223-228
31627175-2	2019	We found that the antioxidant reagent, N-acetyl cysteine (NAC) prevented the abilities of Stattic and BP-1-102, but not LLL12 to induce apoptosis in transformed cells expressing NPM-ALK, providing a novel problem in use of STAT3 inhibitors.	Acetylcysteine	58-61	signal transducer and activator of transcription 3	Mus musculus	223-228
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	Acetylcysteine	13-16	signal transducer and activator of transcription 3	Mus musculus	141-146
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	BP-1-102	59-67	signal transducer and activator of transcription 3	Mus musculus	83-88
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	BP-1-102	59-67	signal transducer and activator of transcription 3	Mus musculus	141-146
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	Cysteine	120-128	signal transducer and activator of transcription 3	Mus musculus	83-88
31627175-11	2019	CONCLUSIONS: NAC antagonizes the activities of Stattic and BP-1-102, which inhibit STAT3 activation by interacting with cysteine residues in STAT3.	Cysteine	120-128	signal transducer and activator of transcription 3	Mus musculus	141-146
31849616-8	2019	Both inhibitors blunted LPA-induced phosphorylation of STAT1 and STAT3, p65, and c-Jun and consequently reduced the secretion of pro-inflammatory cyto-/chemokines (IL-6, TNFalpha, IL-1beta, CXCL10, CXCL2, and CCL5) at non-toxic concentrations.	lysophosphatidic acid	24-27	signal transducer and activator of transcription 3	Mus musculus	65-70
31776330-7	2019	A small-molecule STAT3 inhibitor (C188-9) alleviated EndMT in cultured cells and bile duct ligation (BDL) induced liver fibrosis in mice.	9-(3-hydroxy-2-hydroxymethylprop-1-yl)-guanine	34-40	signal transducer and activator of transcription 3	Mus musculus	17-22
31819365-11	2019	Further molecular modeling analysis indicated that luteolin interacted with STAT3 primarily through hydrogen bond interaction.	Hydrogen	100-108	signal transducer and activator of transcription 3	Mus musculus	76-81
31779213-0	2019	Betulinic Acid Attenuates T-2-Toxin-Induced Testis Oxidative Damage Through Regulation of the JAK2/STAT3 Signaling Pathway in Mice.	betulinic acid	0-14	signal transducer and activator of transcription 3	Mus musculus	99-104
31779213-0	2019	Betulinic Acid Attenuates T-2-Toxin-Induced Testis Oxidative Damage Through Regulation of the JAK2/STAT3 Signaling Pathway in Mice.	T-2 Toxin	26-35	signal transducer and activator of transcription 3	Mus musculus	99-104
31779213-8	2019	Furthermore, BA relieved testicular injury and reduced the number of apoptotic cells, and it significantly decreased the protein expression of Janus kinase 2 (JAK2), signal transducers and activators of transcription 3 (STAT3), caspsae-3, and Bcl-2-associated X protein (Bax).	betulinic acid	13-15	signal transducer and activator of transcription 3	Mus musculus	166-218
31779213-8	2019	Furthermore, BA relieved testicular injury and reduced the number of apoptotic cells, and it significantly decreased the protein expression of Janus kinase 2 (JAK2), signal transducers and activators of transcription 3 (STAT3), caspsae-3, and Bcl-2-associated X protein (Bax).	betulinic acid	13-15	signal transducer and activator of transcription 3	Mus musculus	220-225
31779213-10	2019	We suggest that BA reduced the oxidative damage induced by T-2 toxin, and that these protective effects may be partially mediated by the JAK2/STAT3 signaling pathway.	betulinic acid	16-18	signal transducer and activator of transcription 3	Mus musculus	142-147
31717643-4	2019	Using CT26 tumor-bearing BALB/c mice, we demonstrate in vivo that ajoene extract alleviated muscle degradation by decreasing not only myokines secretion but also janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) and SMADs/forkhead box (FoxO) signaling pathways, thereby suppressing muscle-specific E3 ligases.	ajoene	66-72	signal transducer and activator of transcription 3	Mus musculus	231-236
31733648-13	2019	p-Stat3 expression was increased in both Ntg and GET-1 mice in the ischemia brain at 7 days after tMCAO.	Nitroglycerin	41-44	signal transducer and activator of transcription 3	Mus musculus	2-7
31733648-14	2019	p-Stat3 expression was significantly upregulated in the ipsilateral side in the GET-1 brain than that in the Ntg brain at 7 days after tMCAO.	Nitroglycerin	109-112	signal transducer and activator of transcription 3	Mus musculus	2-7
31733648-15	2019	Furthermore, GET-1 mice treated with AG490 (a JAK2/Stat3 inhibitor) sh owed a significant reduction in neurological deficit along with reduced infarct area and dwarfed astrocytic differentiation in the ipsilateral brain after tMCAO.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	37-42	signal transducer and activator of transcription 3	Mus musculus	51-56
31780948-4	2019	CTS also inhibited the expressions of alpha-smooth muscle actin, tumor necrosis factor-like weak inducer of apoptosis (TWEAK), Fn14, transforming growth factor (TGF)-beta1, Smad4, and phosphorylation of Smad2/3 and STAT3 (Tyr705).	cryptotanshinone	0-3	signal transducer and activator of transcription 3	Mus musculus	215-220
31780948-6	2019	Additionally, CTS also played a similar role as the TGF-beta1 inhibitor or TGF-beta1 siRNA in TGF-beta1/STAT3 signaling pathways in airway remodeling.	cryptotanshinone	14-17	signal transducer and activator of transcription 3	Mus musculus	104-109
31780948-7	2019	The anti-inflammatory effects of CTS against OVA-induced airway remodeling may be through inhibiting STAT3, which further suppresses TWEAK and TGF-beta1 signaling cross talk in asthma.	cryptotanshinone	33-36	signal transducer and activator of transcription 3	Mus musculus	101-106
31699972-3	2019	Treatment with selective STAT3 inhibitor, S3I-201 for 16 weeks significantly attenuated kidney injuries in streptozotocin (STZ) induced diabetic mice, associated with downregulated expression of TGF-beta1, ACE/AT1, and VEGF in diabetic mouse kidneys.	Streptozocin	123-126	signal transducer and activator of transcription 3	Mus musculus	25-30
31563117-0	2019	Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-kappaB and JAK2/STAT3 signaling pathways.	Dopamine	0-8	signal transducer and activator of transcription 3	Mus musculus	115-120
31699972-0	2019	Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice.	Streptozocin	92-95	signal transducer and activator of transcription 3	Mus musculus	14-19
31699972-3	2019	Treatment with selective STAT3 inhibitor, S3I-201 for 16 weeks significantly attenuated kidney injuries in streptozotocin (STZ) induced diabetic mice, associated with downregulated expression of TGF-beta1, ACE/AT1, and VEGF in diabetic mouse kidneys.	Streptozocin	107-121	signal transducer and activator of transcription 3	Mus musculus	25-30
31690344-11	2019	In vitro, siControl-ASC-CCM but not the siTSG-6-ASC-CCM not only suppressed microglial activation and STAT3 phosphorylation but also protected against TNFalpha-induced endothelial permeability as measured by transendothelial electrical resistance and decreased STAT3 phosphorylation.	beta-carboline-3-carboxylic acid methyl ester	24-27	signal transducer and activator of transcription 3	Mus musculus	102-107
31540827-7	2019	In addition, histological and immunohistochemical analyses revealed a decrease in Ki67-positive cells, MMP9-positive cells and p-Stat3Tyr705 cells upon treatment with PEC compared to control samples.	pectolinarigenin	167-170	signal transducer and activator of transcription 3	Mus musculus	129-134
31294483-10	2019	The activation of the JAK/STAT pathway promoted phosphorylation of STAT3 in TGZ-treated mice.	Troglitazone	76-79	signal transducer and activator of transcription 3	Mus musculus	67-72
31032948-9	2019	Then AG490, a JAK2 inhibitor, inhibited p-JAK2, p-STAT3 and RANKL expression.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	5-10	signal transducer and activator of transcription 3	Mus musculus	50-55
31680772-5	2019	The results showed that RA can effectively inhibit the tumor growth through regulating the ratio of CD4+/CD8+ and the secretion of interleukin (IL)-2 and interferon-gamma, inhibiting the expressions of IL-6, IL-10 and signal transducer and activator of transcription 3, thereby up-regulating Bax and Caspase-3 and down-regulating Bcl-2.	rosmarinic acid	24-26	signal transducer and activator of transcription 3	Mus musculus	218-268
31676833-5	2019	Darunavir attenuated HIV and Vpr-induced activation of Stat3, Src, Erk, and cytokines, which are critical for HIVAN pathogenesis.	darunavir	0-9	signal transducer and activator of transcription 3	Mus musculus	55-60
31655606-0	2019	Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling.	dasatinib	0-9	signal transducer and activator of transcription 3	Mus musculus	104-109
31472144-10	2019	Treatment with AG490, an inhibitor of JAK2/STAT3 signaling pathway, enhanced the inhibitory effects of TRIM66 knockdown on cell proliferation, migration and invasion.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	15-20	signal transducer and activator of transcription 3	Mus musculus	43-48
31256326-13	2019	LXW7 may inhibit the activation of FAK and STAT3 signals in combination with integrin alphavbeta3 to restrain neuroinflammation and the antioxidative stress effect of cerium oxide; hence, CeO2@PAA-LXW7 can exert a more robust anti-inflammatory and neuroprotective effect via synergistically suppressing the ability of LXW7 to influence the integrin pathway and the free radical-scavenging ability of CeO2@PAA.	ceric oxide	188-192	signal transducer and activator of transcription 3	Mus musculus	43-48
31382833-9	2019	In vivo experiments indicated that PCG/pGRIM-19 therapy down-regulated STAT3, NF-kappaB and MMP9 expression in tumor tissues.	pgrim-19	39-47	signal transducer and activator of transcription 3	Mus musculus	71-76
31623025-6	2019	RESULTS: The results show that EBI induced interleukin (IL)-10-producing dendritic cells (DCs) via increasing IL-35 and signal transducer and activator of transcription 3 (STAT3) phosphorylation.	1,2-Diisothiocyanatoethane	31-34	signal transducer and activator of transcription 3	Mus musculus	120-170
31623025-6	2019	RESULTS: The results show that EBI induced interleukin (IL)-10-producing dendritic cells (DCs) via increasing IL-35 and signal transducer and activator of transcription 3 (STAT3) phosphorylation.	1,2-Diisothiocyanatoethane	31-34	signal transducer and activator of transcription 3	Mus musculus	172-177
31279903-9	2019	Furthermore, our results from in vivo and in vitro mechanistic studies revealed that after CCl4 plus ethanol exposure, Aldh2-deficient hepatocytes produced a large amount of harmful oxidized mitochondrial DNA via extracellular vesicles, which were then transferred into neighboring HCC cells and together with acetaldehyde activated multiple oncogenic pathways (JNK, STAT3, BCL-2, and TAZ), thereby promoting HCC.	Ethanol	101-108	signal transducer and activator of transcription 3	Mus musculus	367-372
31356966-0	2019	Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation.	Glucosides	6-16	signal transducer and activator of transcription 3	Mus musculus	114-119
31630150-0	2019	Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and Activator of Transcription-3 (STAT3) Activation.	esculetin	0-9	signal transducer and activator of transcription 3	Mus musculus	131-181
31630150-0	2019	Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and Activator of Transcription-3 (STAT3) Activation.	esculetin	0-9	signal transducer and activator of transcription 3	Mus musculus	183-188
31630150-5	2019	Flow cytometry was conducted to analyze the effect of esculetin on cell cycle of LC cells, and Western blot analysis was used to assess the effect esculetin on the JAK-STAT signaling pathway.	esculetin	147-156	signal transducer and activator of transcription 3	Mus musculus	168-172
31630150-7	2019	Our molecular mechanism study demonstrated that esculetin significantly inhibits STAT3 phosphorylation and blocks translocation of STAT3 into the nucleus, and esculetin also blocks the cell cycle in G1/S phase.	esculetin	48-57	signal transducer and activator of transcription 3	Mus musculus	81-86
31630150-7	2019	Our molecular mechanism study demonstrated that esculetin significantly inhibits STAT3 phosphorylation and blocks translocation of STAT3 into the nucleus, and esculetin also blocks the cell cycle in G1/S phase.	esculetin	48-57	signal transducer and activator of transcription 3	Mus musculus	131-136
31630150-8	2019	CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer.	esculetin	62-71	signal transducer and activator of transcription 3	Mus musculus	44-49
31612866-0	2019	The interaction between STAT3 and nAChRalpha1 interferes with nicotine-induced atherosclerosis via Akt/mTOR signaling cascade.	Nicotine	62-70	signal transducer and activator of transcription 3	Mus musculus	24-29
31612866-2	2019	However, the effect of signal transducer and activator of transcription 3 (STAT3)-related inflammatory pathways in nicotine-induced atherosclerosis has been poorly studied.	Nicotine	115-123	signal transducer and activator of transcription 3	Mus musculus	23-73
31612866-2	2019	However, the effect of signal transducer and activator of transcription 3 (STAT3)-related inflammatory pathways in nicotine-induced atherosclerosis has been poorly studied.	Nicotine	115-123	signal transducer and activator of transcription 3	Mus musculus	75-80
31612866-3	2019	This study investigated the transcriptional mechanism of STAT3 in nicotine/nAChRalpha1-induced atherosclerosis.	Nicotine	66-74	signal transducer and activator of transcription 3	Mus musculus	57-62
31612866-7	2019	nAChRalpha1 knockdown significantly decreases the nicotine-induced upregulation of p-STAT3, p-Akt and p-mTOR in vitro, while nAChRalpha1 overexpression has the opposite effects.	Nicotine	50-58	signal transducer and activator of transcription 3	Mus musculus	85-90
31612866-8	2019	The inhibition of STAT3 attenuated nicotine-induced atherosclerosis, by reducing the proliferation and migration of vascular smooth muscle cells and inflammation in macrophages.	Nicotine	35-43	signal transducer and activator of transcription 3	Mus musculus	18-23
31612866-9	2019	Moreover, there is a direct interaction between STAT3 and nAChRalpha1 that modulates STAT3 nuclear translocation and its binding to the Akt promoter region upon nicotine exposure.	Nicotine	161-169	signal transducer and activator of transcription 3	Mus musculus	48-53
31612866-9	2019	Moreover, there is a direct interaction between STAT3 and nAChRalpha1 that modulates STAT3 nuclear translocation and its binding to the Akt promoter region upon nicotine exposure.	Nicotine	161-169	signal transducer and activator of transcription 3	Mus musculus	85-90
31612866-10	2019	Taken together, STAT3 and nAChRalpha1 blockade attenuates nicotine-induced atherosclerosis by reducing the migration and proliferation of vascular smooth muscle cells and inflammation in macrophages via the Akt/mTOR pathway.	Nicotine	58-66	signal transducer and activator of transcription 3	Mus musculus	16-21
31563117-8	2019	Mechanistically, DA reversed IL-1beta-treated nuclear factor-kappa B activation and JAK2/STAT3 phosphorylation.	Dopamine	17-19	signal transducer and activator of transcription 3	Mus musculus	89-94
31330445-6	2019	Phosphorylation of STAT1 and STAT3 induced by LPS was attenuated by telmisartan.	Telmisartan	68-79	signal transducer and activator of transcription 3	Mus musculus	29-34
31614951-5	2019	In conclusion, EGCG can attenuate high-fat-induced hypothalamic inflammation via inhibiting the JAK2/STAT3 signaling pathways in microglia.	epigallocatechin gallate	15-19	signal transducer and activator of transcription 3	Mus musculus	101-106
31437792-7	2019	Therefore, baicalein and baicalin decreased STAT3 activity, further downregulated IFN-gamma-induced PD-L1 expression and subsequently restored T cell sensitivity to kill tumor cells.	baicalin	25-33	signal transducer and activator of transcription 3	Mus musculus	44-49
31522074-8	2019	Additionally, JNJ-treated and irradiation-exposed BTBR mice exhibited decreases in IL-17A-, RORgammaT-, IL-22-, T-bet-, and STAT3-producing CD8+ T cells and increases in ICOS- and Foxp3-producing CD8+ T cells.	btbr	50-54	signal transducer and activator of transcription 3	Mus musculus	124-129
31365165-1	2019	OBJECTIVES: This study aimed to investigate the role of JAK2-STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) in periapical disease caused by Enterococcus faecalis, as well as the correlation between lipoteichoic acid (LTA) in E. faecalis and the activity of the JAK2-STAT3 signaling pathway and osteoclast formation.	lipoteichoic acid	244-247	signal transducer and activator of transcription 3	Mus musculus	61-66
31365165-6	2019	LTA acted on mouse osteoclast precursor cells (RAW264.7 cells); a JAK2 inhibitor (AG490) was used to inhibit the JAK2-STAT3 pathway in RAW264.7 cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	82-87	signal transducer and activator of transcription 3	Mus musculus	118-123
31649548-0	2019	Inhibition of Stat3 Signaling Pathway by Natural Product Pectolinarigenin Attenuates Breast Cancer Metastasis.	pectolinarigenin	57-73	signal transducer and activator of transcription 3	Mus musculus	14-19
31649548-11	2019	Furthermore, pectolinarigenin markedly impaired cancer cell migration and invasion by down-regulating phosphorylated-Stat3, and expression of matrix metalloproteinase (MMP)-2, MMP-9, while up-regulating the expression of TIMP2.	pectolinarigenin	13-29	signal transducer and activator of transcription 3	Mus musculus	117-122
31649548-13	2019	Conclusions: Pectolinarigenin might potentially be a candidate for metastasis of breast cancer by mediating Stat3 pathway.	pectolinarigenin	13-29	signal transducer and activator of transcription 3	Mus musculus	108-113
31399192-9	2019	The inhibitory effect of NR4A3 on NF-kappaB activation was almost completely abolished by the JAK2 inhibitor AG490, indicating that NR4A3 prevented serum deprivation induced NF-kappaB activation in a STAT3 dependent manner.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	109-114	signal transducer and activator of transcription 3	Mus musculus	200-205
31299319-0	2019	The Stat3 inhibitor, S3I-201, downregulates lymphocyte activation markers, chemokine receptors, and inflammatory cytokines in the BTBR T+ Itpr3tf/J mouse model of autism.	NSC 74859	21-28	signal transducer and activator of transcription 3	Mus musculus	4-9
31321478-0	2019	S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver.	Ethanol	96-103	signal transducer and activator of transcription 3	Mus musculus	71-76
31551033-3	2019	Stattic, a small molecular STAT3 inhibitor, can partially ameliorate lupus nephritis in mice.	stattic	0-7	signal transducer and activator of transcription 3	Mus musculus	27-32
31365165-1	2019	OBJECTIVES: This study aimed to investigate the role of JAK2-STAT3 (Janus kinase 2/signal transducer and activator of transcription 3) in periapical disease caused by Enterococcus faecalis, as well as the correlation between lipoteichoic acid (LTA) in E. faecalis and the activity of the JAK2-STAT3 signaling pathway and osteoclast formation.	lipoteichoic acid	225-242	signal transducer and activator of transcription 3	Mus musculus	61-66
31558703-0	2019	Correction: Inhibition of Stat3 signaling pathway by nifuroxazide improves antitumor immunity and impairs colorectal carcinoma metastasis.	nifuroxazide	53-65	signal transducer and activator of transcription 3	Mus musculus	26-31
31572001-13	2019	The tumor xenograft mice model was further confirmed that emodin possessed a synergy anticancer effect with afatinib on pancreatic cancer cells by regulating the Stat3 expression.	Emodin	58-64	signal transducer and activator of transcription 3	Mus musculus	162-167
31572001-13	2019	The tumor xenograft mice model was further confirmed that emodin possessed a synergy anticancer effect with afatinib on pancreatic cancer cells by regulating the Stat3 expression.	afatinib	108-116	signal transducer and activator of transcription 3	Mus musculus	162-167
31583048-0	2019	Resveratrol Inhibits MMP3 and MMP9 Expression and Secretion by Suppressing TLR4/NF-kappaB/STAT3 Activation in Ox-LDL-Treated HUVECs.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	90-95
31511071-8	2019	Importantly, we found niclosamide could decrease the expression of PD-L1 in both a concentration- and time-dependent manner in NSCLC cells, which was linked to the blockage of p-STAT3 binding to the promoter of PD-L1.	Niclosamide	22-33	signal transducer and activator of transcription 3	Mus musculus	178-183
31506552-3	2019	When combined with cryptotanshinone (CPT), an inhibitor of STAT3-p-Y705, the liver metastasis was further inhibited.	cryptotanshinone	19-35	signal transducer and activator of transcription 3	Mus musculus	59-64
31506552-3	2019	When combined with cryptotanshinone (CPT), an inhibitor of STAT3-p-Y705, the liver metastasis was further inhibited.	cryptotanshinone	37-40	signal transducer and activator of transcription 3	Mus musculus	59-64
31564876-0	2019	Repeated intravenous administration of silica nanoparticles induces pulmonary inflammation and collagen accumulation via JAK2/STAT3 and TGF-beta/Smad3 pathways in vivo.	Silicon Dioxide	39-45	signal transducer and activator of transcription 3	Mus musculus	126-131
31511071-9	2019	CONCLUSIONS: An enhancement of PD-L1 antibody by niclosamide was observed in inhibition of NSCLC growth in vitro and in vivo, which was involved in blockage of p-STAT3 binding to promoter of PD-L1 and finally downregulation of PD-L1 expression.	Niclosamide	49-60	signal transducer and activator of transcription 3	Mus musculus	162-167
31474764-6	2019	In vitro studies show that PA increases STAT3 expression and phosphorylation (STAT3-Y705) in PCa.	Palmitic Acid	27-29	signal transducer and activator of transcription 3	Mus musculus	40-45
31503282-4	2019	STAT3 inhibition was performed by topical application of STAT3 inhibitor S3I-201.	NSC 74859	73-80	signal transducer and activator of transcription 3	Mus musculus	0-5
31503282-4	2019	STAT3 inhibition was performed by topical application of STAT3 inhibitor S3I-201.	NSC 74859	73-80	signal transducer and activator of transcription 3	Mus musculus	57-62
31503282-11	2019	Compared with tofacitinib and ruxolitinib, the STAT3 inhibitor S3I-201 showed superior improvement of tear production and inflammatory cytokine expression in lacrimal gland.	NSC 74859	63-70	signal transducer and activator of transcription 3	Mus musculus	47-52
31565031-0	2019	Inhibition of MAPK and STAT3-SOCS3 by Sakuranetin Attenuated Chronic Allergic Airway Inflammation in Mice.	sakuranetin	38-49	signal transducer and activator of transcription 3	Mus musculus	23-28
31565031-4	2019	Our aim was to clarify how sakuranetin treatment affects MAPK and STAT3-SOCS3 pathways in a murine experimental asthma model.	sakuranetin	27-38	signal transducer and activator of transcription 3	Mus musculus	66-71
31565031-10	2019	Considering possible mechanisms, sakuranetin inhibits the activation of ERK1/2, JNK, p38, and STAT3 in the lungs.	sakuranetin	33-44	signal transducer and activator of transcription 3	Mus musculus	94-99
31565031-13	2019	In conclusion, our data showed that the inhibitory effects of sakuranetin on eosinophilic lung inflammation can be due to the inhibition of Th2 and Th17 cytokines and the inhibition of MAPK and STAT3 pathways, reinforcing the idea that sakuranetin can be considered a relevant candidate for the treatment of inflammatory allergic airway disease.	sakuranetin	62-73	signal transducer and activator of transcription 3	Mus musculus	194-199
31474764-6	2019	In vitro studies show that PA increases STAT3 expression and phosphorylation (STAT3-Y705) in PCa.	Palmitic Acid	27-29	signal transducer and activator of transcription 3	Mus musculus	78-83
31474764-7	2019	Computational modeling suggests strong and stable binding between PA and unphosphorylated STAT3 at R593 and N538.	Palmitic Acid	66-68	signal transducer and activator of transcription 3	Mus musculus	90-95
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	115-117	signal transducer and activator of transcription 3	Mus musculus	34-39
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	115-117	signal transducer and activator of transcription 3	Mus musculus	70-75
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	115-117	signal transducer and activator of transcription 3	Mus musculus	70-75
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	150-152	signal transducer and activator of transcription 3	Mus musculus	34-39
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	150-152	signal transducer and activator of transcription 3	Mus musculus	70-75
31474764-9	2019	Functional studies show that both STAT3 mutants (R583A and N538A) and STAT3 dominant negative significantly reduce PA-enhanced STAT3 phosphorylation, PA-increased PCa cell proliferation, migration, and invasion.	Palmitic Acid	150-152	signal transducer and activator of transcription 3	Mus musculus	70-75
31474764-11	2019	Our study not only demonstrates the regulatory role of PA/STAT3 axis in HFD-associated PCa growth but also suggests a novel mechanism of how STAT3 is activated by PA.	Palmitic Acid	55-57	signal transducer and activator of transcription 3	Mus musculus	141-146
30768366-11	2019	Phosphorylation of STAT3 was decreased in the Leu group relative to the control in both mice (p = 0.019) and myotubes (p = 0.02), but did not significantly attenuate the inflammatory effect of LLC implantation (p = 0.619).	Leucine	46-49	signal transducer and activator of transcription 3	Mus musculus	19-24
31170498-8	2019	In vitro, astaxanthin inhibited fibroblast activation by modulating Smad2, Akt and STAT3 pathways and suppressed epithelial-to-mesenchymal transition in renal tubular epithelial cells through Smad2, snail, and beta-catenin.	astaxanthine	10-21	signal transducer and activator of transcription 3	Mus musculus	83-88
31313354-11	2019	It was concluded that SA has a potential to limit inflammation via inhibiting the p65-NF-kappaB and STAT3 signaling; hence it can be used for therapeutic purposes.	syringic acid	22-24	signal transducer and activator of transcription 3	Mus musculus	100-105
31177018-3	2019	Cryptotanshinone (CTS) is an effective inhibitor of STAT3; however its potential as a SLE treatment remains to be explored.	cryptotanshinone	0-16	signal transducer and activator of transcription 3	Mus musculus	52-57
31177018-3	2019	Cryptotanshinone (CTS) is an effective inhibitor of STAT3; however its potential as a SLE treatment remains to be explored.	cryptotanshinone	18-21	signal transducer and activator of transcription 3	Mus musculus	52-57
31177018-9	2019	All these data suggested that CTS treatment depressed STAT3 phosphorylation, which resulted in blocked DN T cell proliferation and finally attenuated the spontaneous SLE development.	cryptotanshinone	30-33	signal transducer and activator of transcription 3	Mus musculus	54-59
31177018-5	2019	Firstly, we found CTS treatment reversed the elevated STAT3 signaling of spleens in lupus-prone MRL/lpr mice, accompanying with a dramatically decreased number of T cells, especially double-negative (DN) T cells.	cryptotanshinone	18-21	signal transducer and activator of transcription 3	Mus musculus	54-59
31261036-0	2019	Carbenoxolone ameliorates hepatic lipid metabolism and inflammation in obese mice induced by high fat diet via regulating the JAK2/STAT3 signaling pathway.	Carbenoxolone	0-13	signal transducer and activator of transcription 3	Mus musculus	131-136
31250048-1	2019	OBJECTIVE: To explore AG490 (the inhibitor of Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway) in cisplatin (DDP)-induced acute kidney injury (AKI) in mice with lung cancer.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	22-27	signal transducer and activator of transcription 3	Mus musculus	117-121
31250048-1	2019	OBJECTIVE: To explore AG490 (the inhibitor of Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway) in cisplatin (DDP)-induced acute kidney injury (AKI) in mice with lung cancer.	Cisplatin	137-146	signal transducer and activator of transcription 3	Mus musculus	117-121
31250048-1	2019	OBJECTIVE: To explore AG490 (the inhibitor of Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway) in cisplatin (DDP)-induced acute kidney injury (AKI) in mice with lung cancer.	Cisplatin	148-151	signal transducer and activator of transcription 3	Mus musculus	117-121
31261036-13	2019	Besides, treatment with CBX could significantly decrease levels of inflammatory factors such as IL-6 (Interleukin 6) and TNF-a (Tumor necrosis factor-a), increase expressions of phosphorylated JAK2 and phosphorylated STAT3, decrease the expressions of SOCS-3, SREBP-1 and FAS in the liver.	Carbenoxolone	24-27	signal transducer and activator of transcription 3	Mus musculus	217-222
31261036-14	2019	In conclusion, through activating the JAK2/STAT3 signaling pathway in liver and reducing the expression of SCOCS-3, CBX could further decrease the expressions of SREBP-1c, FAS and ameliorate the inflammatory state of liver, so as to protecting the liver from lipid metabolism damage induced by high-fat diet.	Carbenoxolone	116-119	signal transducer and activator of transcription 3	Mus musculus	43-48
29683343-0	2019	Allicin inhibits mouse colorectal tumorigenesis through suppressing the activation of STAT3 signaling pathway.	allicin	0-7	signal transducer and activator of transcription 3	Mus musculus	86-91
31277074-0	2019	Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes.	Streptozocin	54-68	signal transducer and activator of transcription 3	Mus musculus	19-24
31277074-4	2019	Our results indicated that, in diabetic mice, the blockade of STAT3 or EGFR using selective inhibitors S3I-201 and erlotinib, respectively, abrogated the increased activating STAT3 phosphorylation and the induction of genes regulating fibrosis and hypertrophy in myocardial tissue.	NSC 74859	103-110	signal transducer and activator of transcription 3	Mus musculus	62-67
31277074-4	2019	Our results indicated that, in diabetic mice, the blockade of STAT3 or EGFR using selective inhibitors S3I-201 and erlotinib, respectively, abrogated the increased activating STAT3 phosphorylation and the induction of genes regulating fibrosis and hypertrophy in myocardial tissue.	NSC 74859	103-110	signal transducer and activator of transcription 3	Mus musculus	175-180
31277074-4	2019	Our results indicated that, in diabetic mice, the blockade of STAT3 or EGFR using selective inhibitors S3I-201 and erlotinib, respectively, abrogated the increased activating STAT3 phosphorylation and the induction of genes regulating fibrosis and hypertrophy in myocardial tissue.	Erlotinib Hydrochloride	115-124	signal transducer and activator of transcription 3	Mus musculus	62-67
31277074-4	2019	Our results indicated that, in diabetic mice, the blockade of STAT3 or EGFR using selective inhibitors S3I-201 and erlotinib, respectively, abrogated the increased activating STAT3 phosphorylation and the induction of genes regulating fibrosis and hypertrophy in myocardial tissue.	Erlotinib Hydrochloride	115-124	signal transducer and activator of transcription 3	Mus musculus	175-180
31277074-6	2019	In cultured cardiomyocytes, high-concentration glucose induced EGFR-mediated STAT3 phosphorylation.	Glucose	47-54	signal transducer and activator of transcription 3	Mus musculus	77-82
31462771-12	2019	Our studies reveal that fatty-acid- and ZDHHC19-mediated palmitoylation are signals that regulate STAT3, which provides evidence linking the deregulation of palmitoylation to inflammation and cancer.	Fatty Acids	24-34	signal transducer and activator of transcription 3	Mus musculus	98-103
31511209-0	2019	[Calenduloside E inhibits lipopolysaccharide-induced inflammatory response by inhibiting activation of ROS-mediated JAK1-stat3 signaling pathway in RAW264.7 cells].	calenduloside E	1-16	signal transducer and activator of transcription 3	Mus musculus	121-126
31129432-0	2019	Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2-STAT3 signaling pathway.	Artesunate	23-33	signal transducer and activator of transcription 3	Mus musculus	143-148
31511209-7	2019	Calenduloside E dose-dependently decreased the expression levels of iNOS and COX-2 induced by LPS, inhibited LPS-induced release of TNF-alpha and IL-1beta, and suppressed LPS-induced JAK1-stat3 signaling pathway activation and stat3 nuclear translocation.	calenduloside	0-13	signal transducer and activator of transcription 3	Mus musculus	227-232
31481954-13	2019	Important fibrosis pathway proteins such as TGF-beta, NF-kappaB, Smad3, p-Smad3, STAT3, and p-STAT3 were significantly elevated at week 6 in the HOCl110 group.	hocl110	145-152	signal transducer and activator of transcription 3	Mus musculus	94-99
31511209-0	2019	[Calenduloside E inhibits lipopolysaccharide-induced inflammatory response by inhibiting activation of ROS-mediated JAK1-stat3 signaling pathway in RAW264.7 cells].	Reactive Oxygen Species	103-106	signal transducer and activator of transcription 3	Mus musculus	121-126
31511209-7	2019	Calenduloside E dose-dependently decreased the expression levels of iNOS and COX-2 induced by LPS, inhibited LPS-induced release of TNF-alpha and IL-1beta, and suppressed LPS-induced JAK1-stat3 signaling pathway activation and stat3 nuclear translocation.	calenduloside	0-13	signal transducer and activator of transcription 3	Mus musculus	188-193
31511209-9	2019	CONCLUSIONS: Calenduloside E inhibits LPS-induced inflammatory response by blocking ROS-mediated activation of JAK1-stat3 signaling pathway in RAW264.7 cells.	calenduloside E	13-28	signal transducer and activator of transcription 3	Mus musculus	116-121
31511209-9	2019	CONCLUSIONS: Calenduloside E inhibits LPS-induced inflammatory response by blocking ROS-mediated activation of JAK1-stat3 signaling pathway in RAW264.7 cells.	Reactive Oxygen Species	84-87	signal transducer and activator of transcription 3	Mus musculus	116-121
31438567-4	2019	Immunohistochemistry on a retrospective UBC cohort uncovered that STAT3 Y705 phosphorylation (pSTAT3) is significantly increased in infiltrating basal-type UBC compared to luminal UBC.	1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione	40-43	signal transducer and activator of transcription 3	Mus musculus	66-71
31438567-4	2019	Immunohistochemistry on a retrospective UBC cohort uncovered that STAT3 Y705 phosphorylation (pSTAT3) is significantly increased in infiltrating basal-type UBC compared to luminal UBC.	1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione	156-159	signal transducer and activator of transcription 3	Mus musculus	66-71
31438567-4	2019	Immunohistochemistry on a retrospective UBC cohort uncovered that STAT3 Y705 phosphorylation (pSTAT3) is significantly increased in infiltrating basal-type UBC compared to luminal UBC.	1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione	156-159	signal transducer and activator of transcription 3	Mus musculus	66-71
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	signal transducer and activator of transcription 3	Mus musculus	0-57
31583048-9	2019	Resveratrol attenuated the phosphorylation of the transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) that was induced by ox-LDL and LPS.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	110-160
31583048-9	2019	Resveratrol attenuated the phosphorylation of the transcription factors nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription 3 (STAT3) that was induced by ox-LDL and LPS.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	162-167
31583048-13	2019	The mechanism of action of resveratrol may be associated with the suppression of NF-kappaB and STAT3 phosphorylation and restoration of Sirt1 expression.	Resveratrol	27-38	signal transducer and activator of transcription 3	Mus musculus	95-100
31592235-7	2019	Signal transducer and activator of transcription (STAT) 3, p-STAT3, enhancer of zeste homolog 2 (EZH2) and EZH2 mediated trimethylation of histone H3 lysine 27 (H3K27me3) were considerably elevated, too.	Lysine	150-156	signal transducer and activator of transcription 3	Mus musculus	61-66
31419797-13	2019	In addition, NEO100 blocks the activation of the kinases Src, p42/44 MAPK, Akt, and Stat3, all related to cell proliferation and migration.	perillyl alcohol	13-19	signal transducer and activator of transcription 3	Mus musculus	84-89
31426846-16	2019	UC-MSCs combined with decitabine activate the IL4R/STAT6/STAT3/PPARgamma axis to further promote M2 macrophage polarization in adipose tissue, reduce inflammation, improve insulin sensitivity, and lead to better glucose metabolism and long-term hypoglycemic effects.	Decitabine	22-32	signal transducer and activator of transcription 3	Mus musculus	57-62
31497193-0	2019	Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway.	Dimethyl Fumarate	0-17	signal transducer and activator of transcription 3	Mus musculus	92-97
31497193-8	2019	Treatment with DMF activated SOCS3, which led to repression of JAK1 and STAT3 phosphorylation.	Dimethyl Fumarate	15-18	signal transducer and activator of transcription 3	Mus musculus	72-77
31497193-9	2019	DMF inhibited cell proliferation, angiogenesis, and autophagy via activation of the SOCS3/JAK1/STAT3 signaling pathway.	Dimethyl Fumarate	0-3	signal transducer and activator of transcription 3	Mus musculus	95-100
31409825-5	2019	IL-6-mediated activation of STAT3 was repressed after RORalpha activation by either adenoviral infusion of RORalpha or JC1-40 treatment in primary hepatocytes.	jc1-40	119-125	signal transducer and activator of transcription 3	Mus musculus	28-33
31202798-8	2019	In addition, it was found that DZNep blocked the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in microglia, which was increased by I/R injury and OGD.	3-deazaneplanocin	31-36	signal transducer and activator of transcription 3	Mus musculus	68-118
31202798-8	2019	In addition, it was found that DZNep blocked the phosphorylation of signal transducer and activator of transcription 3 (STAT3) in microglia, which was increased by I/R injury and OGD.	3-deazaneplanocin	31-36	signal transducer and activator of transcription 3	Mus musculus	120-125
31202798-9	2019	Collectively, we demonstrated that EZH2 is implicated in regulating microglial activation and exacerbates neurological deficits after ischaemic stroke, probably via activating STAT3, and that the EZH2 inhibitor DZNep can exert neuroprotective effects after ischaemic stroke.	3-deazaneplanocin	211-216	signal transducer and activator of transcription 3	Mus musculus	176-181
31481954-13	2019	Important fibrosis pathway proteins such as TGF-beta, NF-kappaB, Smad3, p-Smad3, STAT3, and p-STAT3 were significantly elevated at week 6 in the HOCl110 group.	hocl110	145-152	signal transducer and activator of transcription 3	Mus musculus	81-86
31178135-7	2019	CA-FA also inhibited the LPS-induced phosphorylations of STAT3, Akt, and IkappaB and selectively inhibited LPS-induced NF-kappaB activation.	ca-fa	0-5	signal transducer and activator of transcription 3	Mus musculus	57-62
31078568-0	2019	Inhibition of protein nitration prevents cisplatin-induced inactivation of STAT3 and promotes anti-apoptotic signaling in organ of Corti cells.	Cisplatin	41-50	signal transducer and activator of transcription 3	Mus musculus	75-80
31273958-0	2019	Quercetin shows anti-tumor effect in hepatocellular carcinoma LM3 cells by abrogating JAK2/STAT3 signaling pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	91-96
31273958-9	2019	These effects at least partly depended on the down-regulation of the activation of JAK2 and STAT3 by quercetin.	Quercetin	101-110	signal transducer and activator of transcription 3	Mus musculus	92-97
31273958-10	2019	CONCLUSION: Quercetin inhibited hepatocellular carcinoma progression by modulating cell apoptosis, migration, invasion, and autophagy; and its effects were at least partly related with the JAK2/STAT3 signaling pathway.	Quercetin	12-21	signal transducer and activator of transcription 3	Mus musculus	194-199
31078568-7	2019	Inhibition of nitration by SRI110 co-treatment prevented cisplatin-induced inactivation of STAT3 and promoted its nuclear localization.	Cisplatin	57-66	signal transducer and activator of transcription 3	Mus musculus	91-96
31078568-3	2019	Cisplatin-induced nitration and degradation of LMO4 could destabilize this protein complex, which in turn could compromise the downstream STAT3-mediated cellular defense mechanism.	Cisplatin	0-9	signal transducer and activator of transcription 3	Mus musculus	138-143
31078568-4	2019	Here, we investigated the link between cisplatin-induced nitrative stress and STAT3-mediated apoptosis by using organ of Corti cell cultures.	Cisplatin	39-48	signal transducer and activator of transcription 3	Mus musculus	78-83
31078568-8	2019	SRI110 co-treatment reversed the cisplatin-induced changes in the expression levels of Bcl2l1, Ccnd1, Jak2, Jak3, and Src and significantly attenuated the changes in the expression levels of Cdkn1a, Egfr, Fas, Il6st, Jak1, Stat3, and Tyk2.	sri110	0-6	signal transducer and activator of transcription 3	Mus musculus	223-228
31078568-6	2019	Immunoblotting and immunostaining indicated that cisplatin treatment decreased the expression levels, phosphorylation, and nuclear localization of STAT3 in UB/OC1 cells.	Cisplatin	49-58	signal transducer and activator of transcription 3	Mus musculus	147-152
31078568-8	2019	SRI110 co-treatment reversed the cisplatin-induced changes in the expression levels of Bcl2l1, Ccnd1, Jak2, Jak3, and Src and significantly attenuated the changes in the expression levels of Cdkn1a, Egfr, Fas, Il6st, Jak1, Stat3, and Tyk2.	Cisplatin	33-42	signal transducer and activator of transcription 3	Mus musculus	223-228
31078568-9	2019	Collectively, these results suggest that the inhibition of cisplatin-induced nitration prevents the inactivation of STAT3, which in turn enables the transcription of anti-apoptotic genes and thereby helps to mitigate cisplatin-induced toxicity.	Cisplatin	59-68	signal transducer and activator of transcription 3	Mus musculus	116-121
31078568-7	2019	Inhibition of nitration by SRI110 co-treatment prevented cisplatin-induced inactivation of STAT3 and promoted its nuclear localization.	sri110	27-33	signal transducer and activator of transcription 3	Mus musculus	91-96
31078568-9	2019	Collectively, these results suggest that the inhibition of cisplatin-induced nitration prevents the inactivation of STAT3, which in turn enables the transcription of anti-apoptotic genes and thereby helps to mitigate cisplatin-induced toxicity.	Cisplatin	217-226	signal transducer and activator of transcription 3	Mus musculus	116-121
31124216-11	2019	Bisulfite sequencing PCR was applied to reveal the methylation status of the Stat3 promoter region.	hydrogen sulfite	0-9	signal transducer and activator of transcription 3	Mus musculus	77-82
31250538-9	2019	Other studies have suggested that metformin regulates monocyte maturation through signal transducer and activator of transcription 3 (STAT3) activation, as also indicated by our results.	Metformin	34-43	signal transducer and activator of transcription 3	Mus musculus	82-132
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Water	0-5	signal transducer and activator of transcription 3	Mus musculus	144-149
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Polysaccharides	14-29	signal transducer and activator of transcription 3	Mus musculus	144-149
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Cyclophosphamide	105-121	signal transducer and activator of transcription 3	Mus musculus	144-149
31257541-6	2019	The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO-1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.	sulforaphane	33-45	signal transducer and activator of transcription 3	Mus musculus	187-192
31250538-9	2019	Other studies have suggested that metformin regulates monocyte maturation through signal transducer and activator of transcription 3 (STAT3) activation, as also indicated by our results.	Metformin	34-43	signal transducer and activator of transcription 3	Mus musculus	134-139
31638567-10	2019	Conclusion The activation of STAT3/NF-kappaB pathway by Klotho is involved in the regulation of the occurrence and development of AKI induced by cisplatin in mice.	Cisplatin	145-154	signal transducer and activator of transcription 3	Mus musculus	29-34
31440530-6	2019	Furthermore, pharmacologic inhibition of Stat3 in osteocytes in vitro with WP1066 blocked the increase in cytosolic calcium induced by ATP, a mediator of the cellular responses to sheer stress.	Calcium	116-123	signal transducer and activator of transcription 3	Mus musculus	41-46
31440530-6	2019	Furthermore, pharmacologic inhibition of Stat3 in osteocytes in vitro with WP1066 blocked the increase in cytosolic calcium induced by ATP, a mediator of the cellular responses to sheer stress.	Adenosine Triphosphate	135-138	signal transducer and activator of transcription 3	Mus musculus	41-46
31161238-5	2019	CT inhibited the proliferation of mouse hepatoma (Hepa1-6) cells in vitro by inducing Hepa1-6 cells apoptosis through the JAK2/STAT3 signaling pathway.	cryptotanshinone	0-2	signal transducer and activator of transcription 3	Mus musculus	127-132
31155707-5	2019	Prostaglandin E2 (PGE2 )-induced Osm in mouse uterine epithelial cells upregulates the levels of Il-33 expression and phosphorylates Stat3.	Dinoprostone	0-16	signal transducer and activator of transcription 3	Mus musculus	133-138
31155707-5	2019	Prostaglandin E2 (PGE2 )-induced Osm in mouse uterine epithelial cells upregulates the levels of Il-33 expression and phosphorylates Stat3.	Dinoprostone	18-22	signal transducer and activator of transcription 3	Mus musculus	133-138
31155707-7	2019	Our results indicate that PGE2 -induced Osm may mediate embryo implantation through Il-33 and participate in decidualization via the Stat3-Egr1 pathway.	Dinoprostone	26-30	signal transducer and activator of transcription 3	Mus musculus	133-138
31379980-5	2019	To further examine the connection between CXCL16 and STAT3 in mouse LF cells, the STAT3 inhibitor AG490 was utilized to inhibit the expression of STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	98-103	signal transducer and activator of transcription 3	Mus musculus	82-87
31379980-5	2019	To further examine the connection between CXCL16 and STAT3 in mouse LF cells, the STAT3 inhibitor AG490 was utilized to inhibit the expression of STAT3.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	98-103	signal transducer and activator of transcription 3	Mus musculus	82-87
31379980-10	2019	However, the effect of CXCL16 was deeply abolished by the STAT3 inhibitor AG490 in LF cells.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	74-79	signal transducer and activator of transcription 3	Mus musculus	58-63
31379467-0	2019	Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3.	dhts	0-19	signal transducer and activator of transcription 3	Mus musculus	145-150
31379467-0	2019	Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3.	Silicon Dioxide	43-49	signal transducer and activator of transcription 3	Mus musculus	145-150
31379467-7	2019	It significantly ameliorated CS-induced pulmonary inflammation by attenuating T helper (Th)1 and Th17 responses, which were tightly related to the inhibition of STAT1 and STAT3.	Cesium	29-31	signal transducer and activator of transcription 3	Mus musculus	171-176
31277592-0	2019	The PPARgamma agonist pioglitazone prevents TGF-beta induced renal fibrosis by repressing EGR-1 and STAT3.	Pioglitazone	22-34	signal transducer and activator of transcription 3	Mus musculus	100-105
31277592-9	2019	Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-beta1, CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation.	Pioglitazone	0-12	signal transducer and activator of transcription 3	Mus musculus	205-210
31277592-10	2019	CONCLUSIONS: Oral administration of PPARgamma agonist pioglitazone significantly reduces TGF-beta1-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1.	Pioglitazone	54-66	signal transducer and activator of transcription 3	Mus musculus	152-157
31042082-0	2019	Organic dust induces inflammatory gene expression in lung epithelial cells via ROS-dependent STAT-3 activation.	Reactive Oxygen Species	79-82	signal transducer and activator of transcription 3	Mus musculus	93-99
31042082-7	2019	Antioxidants suppressed the increase of STAT-3 phosphorylation induced by poultry dust extract indicating that oxidative stress [elevated reactive oxygen species (ROS) levels] is important for the activation.	Reactive Oxygen Species	138-161	signal transducer and activator of transcription 3	Mus musculus	40-46
31042082-7	2019	Antioxidants suppressed the increase of STAT-3 phosphorylation induced by poultry dust extract indicating that oxidative stress [elevated reactive oxygen species (ROS) levels] is important for the activation.	Reactive Oxygen Species	163-166	signal transducer and activator of transcription 3	Mus musculus	40-46
30958891-6	2019	Mice were treated with either adeno-associated virus expressing STAT3 shRNA or STAT3 inhibitor, S3I-201.	NSC 74859	96-103	signal transducer and activator of transcription 3	Mus musculus	79-84
30958891-8	2019	In vitro, STAT3 was blocked using siRNA or STAT3 inhibitor S3I-201 in the renal proximal tubular cell line, NRK52E, after exposure to angiotensin II.	NSC 74859	59-66	signal transducer and activator of transcription 3	Mus musculus	10-15
30958891-8	2019	In vitro, STAT3 was blocked using siRNA or STAT3 inhibitor S3I-201 in the renal proximal tubular cell line, NRK52E, after exposure to angiotensin II.	NSC 74859	59-66	signal transducer and activator of transcription 3	Mus musculus	43-48
30947085-10	2019	Liver injury induced by CDO14 was mediated by the JAK2-STAT3 signaling pathway.	cdo14	24-29	signal transducer and activator of transcription 3	Mus musculus	55-60
30913451-5	2019	IL-33 reduces the CD4+ and CD8+ cells, inhibits autophagy in IMQ-treated mouse skin, and promoted tyrosyl phosphorylation of STAT3.	cyclo(tyrosyl-tyrosyl)	98-105	signal transducer and activator of transcription 3	Mus musculus	125-130
30902796-5	2019	Furthermore, alisertib treatment disrupted the immunosuppressive functions of MDSC by inhibiting Stat3-mediated ROS production.	MLN 8237	13-22	signal transducer and activator of transcription 3	Mus musculus	97-102
30902796-5	2019	Furthermore, alisertib treatment disrupted the immunosuppressive functions of MDSC by inhibiting Stat3-mediated ROS production.	ros	112-115	signal transducer and activator of transcription 3	Mus musculus	97-102
30806670-6	2019	Sunitinib exerts its regenerative effects via transient inhibition of SHP-2 and subsequent activation of the STAT3 pathway.	Sunitinib	0-9	signal transducer and activator of transcription 3	Mus musculus	109-114
31075711-6	2019	Immunohistochemistry revealed that shikonin potently suppresses the JAK/STAT3 signaling pathway in local skin lesions and increases CEBPD expression.	shikonin	35-43	signal transducer and activator of transcription 3	Mus musculus	72-77
31075711-7	2019	These results imply that shikonin inhibits keratinocyte proliferation and induces apoptosis, which results in psoriasis treatment through the JAK/STAT3 dependent pathway.	shikonin	25-33	signal transducer and activator of transcription 3	Mus musculus	146-151
31095941-5	2019	In support, reperfusion enhanced STAT3 phosphorylation (Tyr705), which was blocked by ZnCl2, implying that STAT3 is activated in response to zinc loss.	zinc chloride	86-91	signal transducer and activator of transcription 3	Mus musculus	33-38
31095941-5	2019	In support, reperfusion enhanced STAT3 phosphorylation (Tyr705), which was blocked by ZnCl2, implying that STAT3 is activated in response to zinc loss.	zinc chloride	86-91	signal transducer and activator of transcription 3	Mus musculus	107-112
31252572-6	2019	Consistent with these data, curcumin stimulation upregulates the expression of Suppressors of cytokine signaling (SOCS)-1, whereas phosphorylation of the JAK2 and STAT3 was reduced.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	163-168
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	signal transducer and activator of transcription 3	Mus musculus	145-150
31171577-8	2019	Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis.	Folic Acid	106-116	signal transducer and activator of transcription 3	Mus musculus	356-361
31171577-9	2019	Furthermore, the rescue of the mutant cleft palate using folic acid might highlight potential therapeutic targets aimed at Stat3 modification for the prevention and pharmaceutical intervention of cleft palate.	Folic Acid	57-67	signal transducer and activator of transcription 3	Mus musculus	123-128
31242213-7	2019	Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-alpha gene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development.	dss	32-35	signal transducer and activator of transcription 3	Mus musculus	64-70
31029425-6	2019	Icv injection of an orexin receptor antagonist, SB334867 reduced STAT3 phosphorylation, which was enhanced by icv injection of orexin but not by direct injection of orexin into MBH.	1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea	48-56	signal transducer and activator of transcription 3	Mus musculus	65-70
31388630-7	2019	In human and mouse NASH livers, serum obesity-related factors, such as free fatty acid, leptin, and interleukin-6, dramatically increased the expression of LPL, specifically in HSCs through signal transducer and activator of transcription 3 signaling, as opposed to that in hepatocytes or hepatic macrophages.	Fatty Acids, Nonesterified	71-86	signal transducer and activator of transcription 3	Mus musculus	190-240
31214200-0	2019	IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole.	benzonidazole	70-82	signal transducer and activator of transcription 3	Mus musculus	6-11
31214200-7	2019	Specific inhibition of STAT3 precluded this effect, suggesting a role for STAT3 in the increase of SOCS3 expression induced by benznidazole.	benzonidazole	127-139	signal transducer and activator of transcription 3	Mus musculus	23-28
31214200-7	2019	Specific inhibition of STAT3 precluded this effect, suggesting a role for STAT3 in the increase of SOCS3 expression induced by benznidazole.	benzonidazole	127-139	signal transducer and activator of transcription 3	Mus musculus	74-79
31214200-16	2019	The results reported herein show, for the first time, that the IL-10/STAT3/SOCS3 axis is involved in the anti-inflammatory effects of benznidazole.	benzonidazole	134-146	signal transducer and activator of transcription 3	Mus musculus	69-74
30825385-0	2019	Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine.	methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate	40-48	signal transducer and activator of transcription 3	Mus musculus	81-86
30825385-10	2019	CONCLUSIONS AND IMPLICATIONS: IL-10 suppresses metabolic activation of vicagrel through down-regulation of Aadac in mouse intestine in a STAT3-dependent manner and, consequently, attenuates platelet responses to vicagrel, suggesting that the antiplatelet effect of vicagrel may be modulated by changes in plasma IL-10 levels in relevant clinical settings.	methyl 2-(2-acetoxy-6,7-dihydrothieno(3,2-c)pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate	71-79	signal transducer and activator of transcription 3	Mus musculus	137-142
30852762-9	2019	RESULTS: Our findings demonstrated that bazedoxifene not only decreased the expression of P-STAT3, IL-6/GP130-mediated downstream target genes P-AKT and P-ERK, but also blocked mitogen effects stimulated by IL-6, including cell viability, and overall cell survive, proliferation as well as cell migration.	bazedoxifene	40-52	signal transducer and activator of transcription 3	Mus musculus	92-97
30852762-12	2019	CONCLUSIONS: Taken together, our data suggest that bazedoxifene may be developed as a promising small molecular therapeutic agent for eradicating TNBC intrinsically associated with constitutively active IL-6/GP130/STAT3 signaling cascade.	bazedoxifene	51-63	signal transducer and activator of transcription 3	Mus musculus	214-219
31360692-15	2019	Conclusions: Protective effects of baicalein on DSS-induced colitis are associated with suppression of NF-kappaB and STAT3 signaling pathways, which may contribute to its cancer preventive effects on colon carcinogenesis.	baicalein	35-44	signal transducer and activator of transcription 3	Mus musculus	117-122
31360692-15	2019	Conclusions: Protective effects of baicalein on DSS-induced colitis are associated with suppression of NF-kappaB and STAT3 signaling pathways, which may contribute to its cancer preventive effects on colon carcinogenesis.	Dextran Sulfate	48-51	signal transducer and activator of transcription 3	Mus musculus	117-122
30993885-6	2019	Inhibiting or knockdown of Jagged1 expression could not only reduce its capacity of migration and invasion but also reverse EMT and down-regulate the expression of serine 727-phosphorylated STAT3 (pS727) at the protein level but not total STAT3 or tyrosine 705-phosphorylated STAT3 (pY705) in C13K cells.	Serine	164-170	signal transducer and activator of transcription 3	Mus musculus	190-195
30993885-6	2019	Inhibiting or knockdown of Jagged1 expression could not only reduce its capacity of migration and invasion but also reverse EMT and down-regulate the expression of serine 727-phosphorylated STAT3 (pS727) at the protein level but not total STAT3 or tyrosine 705-phosphorylated STAT3 (pY705) in C13K cells.	Serine	164-170	signal transducer and activator of transcription 3	Mus musculus	239-244
30993885-6	2019	Inhibiting or knockdown of Jagged1 expression could not only reduce its capacity of migration and invasion but also reverse EMT and down-regulate the expression of serine 727-phosphorylated STAT3 (pS727) at the protein level but not total STAT3 or tyrosine 705-phosphorylated STAT3 (pY705) in C13K cells.	Serine	164-170	signal transducer and activator of transcription 3	Mus musculus	239-244
31022374-7	2019	Focusing on the mitochondrial STAT3 localization, our results suggest that serine-phosphorylated STAT3 (PS727-STAT3) and total STAT3 are detected in crude but not in pure mitochondria of mouse adult cardiomyocytes, under basal and ischemia-reperfusion conditions.	Serine	75-81	signal transducer and activator of transcription 3	Mus musculus	30-35
31022374-7	2019	Focusing on the mitochondrial STAT3 localization, our results suggest that serine-phosphorylated STAT3 (PS727-STAT3) and total STAT3 are detected in crude but not in pure mitochondria of mouse adult cardiomyocytes, under basal and ischemia-reperfusion conditions.	Serine	75-81	signal transducer and activator of transcription 3	Mus musculus	97-102
31022374-7	2019	Focusing on the mitochondrial STAT3 localization, our results suggest that serine-phosphorylated STAT3 (PS727-STAT3) and total STAT3 are detected in crude but not in pure mitochondria of mouse adult cardiomyocytes, under basal and ischemia-reperfusion conditions.	Serine	75-81	signal transducer and activator of transcription 3	Mus musculus	97-102
31022374-7	2019	Focusing on the mitochondrial STAT3 localization, our results suggest that serine-phosphorylated STAT3 (PS727-STAT3) and total STAT3 are detected in crude but not in pure mitochondria of mouse adult cardiomyocytes, under basal and ischemia-reperfusion conditions.	Serine	75-81	signal transducer and activator of transcription 3	Mus musculus	97-102
31022374-8	2019	The inhibition of STAT3, with a pre-validated non-toxic Stattic dose, had no significant effects on mitochondrial respiration, but a weak effect on the calcium retention capacity.	Calcium	152-159	signal transducer and activator of transcription 3	Mus musculus	18-23
31005809-9	2019	Furthermore, DT-13 decreased PLOD2 expression through modulating JAK/STAT3 and PI3K/AKT signaling pathways directly or indirectly in the adipocyte-breast cancer microenvironment.	DT-13	13-18	signal transducer and activator of transcription 3	Mus musculus	69-74
30573782-0	2019	B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3.	ros	67-70	signal transducer and activator of transcription 3	Mus musculus	99-104
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	signal transducer and activator of transcription 3	Mus musculus	154-159
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	signal transducer and activator of transcription 3	Mus musculus	202-207
30526368-0	2019	Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway.	methylselenic acid	0-20	signal transducer and activator of transcription 3	Mus musculus	66-71
30914235-10	2019	The bortezomib group exhibited significantly higher expression of pro-apoptotic protein TNF-alpha (p =  0.032), and lower expression of anti-apoptotic protein XIAP, Stat3, and Survivin (p =  0.024, 0.016, and 0.039, respectively).	Bortezomib	4-14	signal transducer and activator of transcription 3	Mus musculus	165-170
31159225-5	2019	This flavonoid is able to counteract the proliferative effects of IL-22/IL6 pathway by the inhibition of STAT3 activity also in vivo in a psoriatic mouse model.	Flavonoids	5-14	signal transducer and activator of transcription 3	Mus musculus	105-110
31146332-0	2019	(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway.	Phenol	53-59	signal transducer and activator of transcription 3	Mus musculus	134-139
31146332-0	2019	(E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	72-76	signal transducer and activator of transcription 3	Mus musculus	134-139
31146332-2	2019	We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	98-102	signal transducer and activator of transcription 3	Mus musculus	117-167
31146332-2	2019	We have previously demonstrated that (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP), a selective signal transducer and activator of transcription 3 (STAT3) inhibitor, has anti-inflammatory properties in several inflammatory disease models.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	98-102	signal transducer and activator of transcription 3	Mus musculus	169-174
31146332-7	2019	Increased activation of STAT3, p38, and monoamine oxidase B (MAO-B) were observed in the substantia nigra and striatum after MPTP injection, effects that were attenuated by MMPP treatment.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	125-129	signal transducer and activator of transcription 3	Mus musculus	24-29
31146332-7	2019	Increased activation of STAT3, p38, and monoamine oxidase B (MAO-B) were observed in the substantia nigra and striatum after MPTP injection, effects that were attenuated by MMPP treatment.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	173-177	signal transducer and activator of transcription 3	Mus musculus	24-29
31146332-8	2019	Furthermore, MMPP inhibited STAT3 activity and expression of neuroinflammatory proteins, including ionized calcium binding adaptor molecule 1 (Iba1), inducible nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in 1-methyl-4-phenylpyridinium (MPP+; 0.5 mM)-treated primary cultured cells.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	13-17	signal transducer and activator of transcription 3	Mus musculus	28-33
31146332-8	2019	Furthermore, MMPP inhibited STAT3 activity and expression of neuroinflammatory proteins, including ionized calcium binding adaptor molecule 1 (Iba1), inducible nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in 1-methyl-4-phenylpyridinium (MPP+; 0.5 mM)-treated primary cultured cells.	mangion-purified polysaccharide (Candida albicans)	14-17	signal transducer and activator of transcription 3	Mus musculus	28-33
31146332-10	2019	Collectively, our results suggest that MMPP may be an anti-inflammatory agent that attenuates dopaminergic neurodegeneration and neuroinflammation through MAO-B and MAPK pathway-dependent inhibition of STAT3 activation.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	39-43	signal transducer and activator of transcription 3	Mus musculus	202-207
30790684-0	2019	STAT3 inhibition enhances CDN-induced STING signaling and antitumor immunity.	chromium dinicotinate	26-29	signal transducer and activator of transcription 3	Mus musculus	0-5
30790684-3	2019	Here we reported that STAT3 inhibition significantly enhanced the intensity and duration of STING signaling induced by the STING agonist c-diAM(PS)2.	c-diam(ps)2	137-148	signal transducer and activator of transcription 3	Mus musculus	22-27
31013055-4	2019	We have synthesized a novel lipase-labile SN-2 phospholipid prodrug from a clinically investigated STAT3 inhibitor, nifuroxazide (Pro-nifuroxazide), which can be regioselectively cleaved by the membrane-abundant enzymes in cancer cells.	nifuroxazide	116-128	signal transducer and activator of transcription 3	Mus musculus	99-104
31013055-4	2019	We have synthesized a novel lipase-labile SN-2 phospholipid prodrug from a clinically investigated STAT3 inhibitor, nifuroxazide (Pro-nifuroxazide), which can be regioselectively cleaved by the membrane-abundant enzymes in cancer cells.	pro-nifuroxazide	130-146	signal transducer and activator of transcription 3	Mus musculus	99-104
31013055-12	2019	Immunostaining on tumor section demonstrated a significantly lower level of pSTAT-3 by Pro-nifuroxazide NP treatment, establishing the inhibition of STAT-3 phosphorylation.	pro-nifuroxazide np	87-106	signal transducer and activator of transcription 3	Mus musculus	77-83
31115390-9	2019	As a result, the activity of the IL-6/Stat3 pathway was inhibited by DHA.	artenimol	69-72	signal transducer and activator of transcription 3	Mus musculus	38-43
31115390-11	2019	CONCLUSIONS Our results suggest that the therapeutic effects of DHA on asthma are partially realized via the regulation of miR-183C and IL-6/Stat3 pathway.	artenimol	64-67	signal transducer and activator of transcription 3	Mus musculus	141-146
31171272-0	2019	Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway.	broussonin E	0-12	signal transducer and activator of transcription 3	Mus musculus	120-125
30935688-0	2019	Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in vitro and in vivo.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	91-141
30935688-6	2019	Furthermore, the effects of metformin on STAT3 expression level and NASH inflammation were investigated.	Metformin	28-37	signal transducer and activator of transcription 3	Mus musculus	41-46
30935688-7	2019	The current results showed that metformin activated autophagy and decreased the mRNA expressions of inflammatory cytokines, IL-1beta, IL-6, and TNF-alpha via inhibition of the STAT3 mRNA and protein expression.	Metformin	32-41	signal transducer and activator of transcription 3	Mus musculus	176-181
30935688-12	2019	In conclusion, this study demonstrated that metformin alleviated the inflammatory response in the liver and the hepatocyte of the NASH model via STAT3-mediated autophagy induction.	Metformin	44-53	signal transducer and activator of transcription 3	Mus musculus	145-150
31171272-6	2019	Moreover, we found that broussonin E could activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3.	broussonin E	24-36	signal transducer and activator of transcription 3	Mus musculus	74-131
31171272-7	2019	Downregulated pro-inflammatory cytokines and upregulated anti-inflammatory factors by broussonin E were abolished by using the inhibitor of JAK2-STAT3 pathway, WP1066.	broussonin E	86-98	signal transducer and activator of transcription 3	Mus musculus	145-150
31171272-8	2019	Taken together, our results showed that broussonin E could suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway, and can be further developed as a promising drug for the treatment of inflammation-related diseases such as atherosclerosis.	broussonin E	40-52	signal transducer and activator of transcription 3	Mus musculus	178-183
31072360-12	2019	In addition, reactive oxygen species could induce CD80 expression via the JNK and p38 MAPK pathways, that activated STAT3 transcription factor in colon cancer epithelial cells.	Reactive Oxygen Species	13-36	signal transducer and activator of transcription 3	Mus musculus	116-121
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	signal transducer and activator of transcription 3	Mus musculus	75-80
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	btbr	30-34	signal transducer and activator of transcription 3	Mus musculus	75-80
31223625-8	2019	We also confirmed this pathway using HNF1alpha-/- mice combining treatment with STAT3 inhibitor NSC 74859 in vivo.	NSC 74859	96-105	signal transducer and activator of transcription 3	Mus musculus	80-85
30963819-9	2019	The proportions of STAT3-related and inflammation-related cell subtypes, such as T helper 1, T helper 17, and follicular T helper cells, were elevated in the SAT group when compared to the control group, and these cell subtypes decreased after FTY720 administration.	Fingolimod Hydrochloride	244-250	signal transducer and activator of transcription 3	Mus musculus	19-24
31073117-0	2019	Urocortin Induces Phosphorylation of Distinct Residues of Signal Transducer and Activator of Transcription 3 (STAT3) via Different Signaling Pathways.	Urocortins	0-9	signal transducer and activator of transcription 3	Mus musculus	58-108
31073117-0	2019	Urocortin Induces Phosphorylation of Distinct Residues of Signal Transducer and Activator of Transcription 3 (STAT3) via Different Signaling Pathways.	Urocortins	0-9	signal transducer and activator of transcription 3	Mus musculus	110-115
31073117-6	2019	Urocortin treatment induced STAT3 phosphorylation at Y705 and S727 through transactivation of JAK2 in an IL-6-dependent manner, but had no effect on STAT1 activity.	Urocortins	0-9	signal transducer and activator of transcription 3	Mus musculus	28-33
31073117-7	2019	Kinase inhibition experiments revealed that urocortin induces STAT3 S727 phosphorylation through ERK1/2 and Y705 phosphorylation through Src tyrosine kinase.	Urocortins	44-53	signal transducer and activator of transcription 3	Mus musculus	62-67
30889487-0	2019	Captopril attenuates TAC-induced heart failure via inhibiting Wnt3a/beta-catenin and Jak2/Stat3 pathways.	Captopril	0-9	signal transducer and activator of transcription 3	Mus musculus	90-95
30889487-11	2019	Cap also attenuated myocardial hypertrophy induced by TAC via suppression of Jak2/Stat3 pathway.	Captopril	0-3	signal transducer and activator of transcription 3	Mus musculus	82-87
30963819-10	2019	Furthermore, the downstream inflammatory cytokines of STAT3 were also downregulated after FTY720 administration.	Fingolimod Hydrochloride	90-96	signal transducer and activator of transcription 3	Mus musculus	54-59
31182999-0	2019	Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-kappaB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.	Sodium Chloride	34-40	signal transducer and activator of transcription 3	Mus musculus	153-158
31182999-0	2019	Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-kappaB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.	Acetic Acid	44-55	signal transducer and activator of transcription 3	Mus musculus	153-158
30236171-12	2019	Taken together, these data suggest that the PRMT1-IL-6-STAT3 axis is an important mechanism of alcohol-associated tumor progression.	Alcohols	95-102	signal transducer and activator of transcription 3	Mus musculus	55-60
31131063-12	2019	In addition, renal fibrosis and inflammation, profibrotic molecules, and EGFR/STAT3/HIPK2 signaling were ameliorated by gefitinib treatment after VAN-induced AKI.	Gefitinib	120-129	signal transducer and activator of transcription 3	Mus musculus	78-83
31131063-14	2019	EGFR/STAT3 signaling mediated VAN-induced HIPK2 expression in HK-2 cells.	Vancomycin	30-33	signal transducer and activator of transcription 3	Mus musculus	5-10
30959824-1	2019	Suavissima) Inhibited LPS-Induced NO Elevation in the Neuroglia BV-2 Cell Line via the JAK2/STAT3 Pathway.	suavissima	0-10	signal transducer and activator of transcription 3	Mus musculus	92-97
30959824-9	2019	STAT3 expression was repressed by tangeretin and 5-demethylnobiletin, but not by nobiletin.	tangeretin	34-44	signal transducer and activator of transcription 3	Mus musculus	0-5
30959824-9	2019	STAT3 expression was repressed by tangeretin and 5-demethylnobiletin, but not by nobiletin.	5-demethylnobiletin	49-68	signal transducer and activator of transcription 3	Mus musculus	0-5
30959824-9	2019	STAT3 expression was repressed by tangeretin and 5-demethylnobiletin, but not by nobiletin.	nobiletin	59-68	signal transducer and activator of transcription 3	Mus musculus	0-5
30959824-10	2019	Western blot assay also showed a suppression of expression and phosphorylation of JAK2 by all three PMF monomers, while STAT3 phosphorylation was restrained by tangeretin and 5-demethylnobiletin.	tangeretin	160-170	signal transducer and activator of transcription 3	Mus musculus	120-125
30959824-10	2019	Western blot assay also showed a suppression of expression and phosphorylation of JAK2 by all three PMF monomers, while STAT3 phosphorylation was restrained by tangeretin and 5-demethylnobiletin.	5-demethylnobiletin	175-194	signal transducer and activator of transcription 3	Mus musculus	120-125
30496353-10	2019	Blocking the different signal transduction pathways downstream of APN, p38MAPK inhibitor (SB203580) and STAT5 inhibitor (Pimozide) could abrogate the regulatory effect of rAPN on FoxP3 and RORgammat expression, while STAT3 inhibitor (Stattic) and AMPK inhibitor (p5499) did not exert any influence.	SB 203580	90-98	signal transducer and activator of transcription 3	Mus musculus	217-222
30797149-9	2019	Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenuated in scutellarin-treated mice.	Cisplatin	63-72	signal transducer and activator of transcription 3	Mus musculus	46-51
30797149-9	2019	Of note, the activations of JNK, ERK, p38 and stat3 induced by cisplatin were strikingly attenuated in scutellarin-treated mice.	scutellarin	103-114	signal transducer and activator of transcription 3	Mus musculus	46-51
30885958-3	2019	Bazedoxifene administration reduced gastric tumor burden in gp130 Y757F mice, where tumors arise exclusively through excessive gp130/STAT3 signaling in response to the IL6 family cytokine IL11.	bazedoxifene	0-12	signal transducer and activator of transcription 3	Mus musculus	133-138
31033039-0	2019	Gambogic acid impairs tumor angiogenesis by targeting YAP/STAT3 signaling axis.	gambogic acid	0-13	signal transducer and activator of transcription 3	Mus musculus	58-63
30885958-5	2019	Consistent with the proposed orthogonal tumor-promoting activity of IL11-dependent gp130/STAT3 signaling, tumors of bazedoxifene-treated Apc-mutant mice retain excessive nuclear accumulation of beta-catenin and aberrant WNT pathway activation.	bazedoxifene	116-128	signal transducer and activator of transcription 3	Mus musculus	89-94
30899259-13	2019	Finally, administration of ruxolitinib for 7 days post-surgery significantly reduced STAT3 phosphorylation in injured muscles in vivo as well as NHO volume at all analyzed time-points up to 3 weeks post-surgery.	ruxolitinib	27-38	signal transducer and activator of transcription 3	Mus musculus	85-90
30830585-6	2019	The intrathecal injection of JAK2 inhibitor AG490 can relieve the abnormal expression of p-JAK2, p-STAT3, t-CAV-1, and p-NR2B, and relieve pain.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	44-49	signal transducer and activator of transcription 3	Mus musculus	99-104
30830585-8	2019	In vitro high-glucose induced the activation of p-STAT3 in microglia, thereby upregulating the expression of p-CAV-1 and p-NR2B in neurons in the co-culture system.	Glucose	14-21	signal transducer and activator of transcription 3	Mus musculus	50-55
30830585-9	2019	JAK2 inhibitor AG490 can alleviate the abnormal expression of these proteins in the JAK2/STAT3-CAV-1-NR2B signaling pathway in vitro.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	15-20	signal transducer and activator of transcription 3	Mus musculus	89-94
30916811-7	2019	A non-linear dose-response of cucurbitacin I, a selective JAK2/STAT3 inhibitor, in collagen type I expression of keloid-derived plasma clot-based skin equivalents implicates a likely role of STAT3 signalling in keloid pathogenesis.	cucurbitacin I	30-44	signal transducer and activator of transcription 3	Mus musculus	63-68
30916811-7	2019	A non-linear dose-response of cucurbitacin I, a selective JAK2/STAT3 inhibitor, in collagen type I expression of keloid-derived plasma clot-based skin equivalents implicates a likely role of STAT3 signalling in keloid pathogenesis.	cucurbitacin I	30-44	signal transducer and activator of transcription 3	Mus musculus	191-196
30585358-7	2019	To further explore the effects of Stat3-mediated pathways on stroke pathogenesis, we subjected mice with an astrocyte-specific conditional deletion of Stat3 to tMCAO, and found that these mice have reduced stroke volume and improved motor outcome 72 hr after focal ischemia.	tmcao	160-165	signal transducer and activator of transcription 3	Mus musculus	151-156
30651189-9	2019	Apatinib suppressed the epithelial-mesenchymal transition in ovarian cancer cells by inhibiting the JAK/STAT3, PI3K/AKT and Notch signalling pathways.	apatinib	0-8	signal transducer and activator of transcription 3	Mus musculus	104-109
30743203-7	2019	Further researches showed that genistein could also significantly inhibit phosphorylated STAT3 (pSAT3) expression in IMQ mice dorsal skin and in TNF-alpha-induced HaCaT cells.	Genistein	31-40	signal transducer and activator of transcription 3	Mus musculus	89-94
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen Sulfide	0-16	signal transducer and activator of transcription 3	Mus musculus	95-145
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen Sulfide	0-16	signal transducer and activator of transcription 3	Mus musculus	147-152
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen Sulfide	0-16	signal transducer and activator of transcription 3	Mus musculus	220-225
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	95-145
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	147-152
30370692-1	2019	Hydrogen sulfide (H2 S) has a significant effect on the regulation of interleukin-6 (IL-6) and signal transducer and activator of transcription 3 (STAT3) activities, while IL-6 directly regulates hepcidin expression via STAT3.	Hydrogen	18-20	signal transducer and activator of transcription 3	Mus musculus	220-225
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	56-60	signal transducer and activator of transcription 3	Mus musculus	142-147
30370692-2	2019	We therefore hypothesized that H 2 S has a role in body iron homeostasis by regulating the expression of iron transport proteins via the IL-6/STAT3/Hepcidin pathway.	Iron	105-109	signal transducer and activator of transcription 3	Mus musculus	142-147
30694753-7	2019	RESULTS: We found that GABA-treated mice had substantial attenuation of terminal deoxynucleotidyl transferase dUTP nick end labeling-positive hepatocytes and hepatocellular necrosis, decreased caspase-3, H2AX, and p38 MAPK protein levels and increased expressions of Jak2, STAT3, Bcl-2, and Mn-SOD, with improved mitochondrial integrity.	gamma-Aminobutyric Acid	23-27	signal transducer and activator of transcription 3	Mus musculus	273-278
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	NSC 74859	29-37	signal transducer and activator of transcription 3	Mus musculus	4-9
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	NSC 74859	29-37	signal transducer and activator of transcription 3	Mus musculus	137-142
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	gamma-Aminobutyric Acid	75-79	signal transducer and activator of transcription 3	Mus musculus	4-9
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	gamma-Aminobutyric Acid	75-79	signal transducer and activator of transcription 3	Mus musculus	137-142
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	gamma-Aminobutyric Acid	154-158	signal transducer and activator of transcription 3	Mus musculus	4-9
30694753-9	2019	The STAT3-specific inhibitor NSC74859 eliminated the survival advantage in GABA-treated mice with ALF, indicating the involvement of the STAT3 pathway in GABA-induced reduction in apoptosis.	gamma-Aminobutyric Acid	154-158	signal transducer and activator of transcription 3	Mus musculus	137-142
30694753-10	2019	CONCLUSIONS: Our results showed that preemptive treatment with GABA protected against severe acute liver injury in mice via GABA-mediated STAT3 signaling.	gamma-Aminobutyric Acid	63-67	signal transducer and activator of transcription 3	Mus musculus	138-143
30694753-10	2019	CONCLUSIONS: Our results showed that preemptive treatment with GABA protected against severe acute liver injury in mice via GABA-mediated STAT3 signaling.	gamma-Aminobutyric Acid	124-128	signal transducer and activator of transcription 3	Mus musculus	138-143
30931933-6	2019	K-80003, a tRXRalpha modulator derived from nonsteroidal anti-inflammatory drug (NSAID) sulindac, suppresses the growth of tRXRalpha-mediated colorectal tumor by inhibiting the NF-kappaB-IL-6-STAT3 signaling cascade.	K-80003	0-7	signal transducer and activator of transcription 3	Mus musculus	192-197
30542122-2	2019	Here, we show that FLLL32, a small molecule inhibitor of JAK2/STAT3 signaling, reduces neurofibroma growth in mice with conditional, biallelic deletion of Nf1 in the Schwann cell lineage.	FLLL 32	19-25	signal transducer and activator of transcription 3	Mus musculus	62-67
30542122-6	2019	FLLL32 suppressed macrophage proliferation, implicating STAT3-dependent, local proliferation in neurofibroma macrophage accumulation, and decreased Schwann cell proliferation and increased Schwann cell death.	FLLL 32	0-6	signal transducer and activator of transcription 3	Mus musculus	56-61
30797070-6	2019	This observation was associated with the downregulation of protein levels of phospho-STAT3 (Tyr 705) and STAT3-regulated immunosuppressive cytokines, and mRNA levels of STAT3-targeted genes involved in tumor growth and immune evasion.	Tyrosine	92-95	signal transducer and activator of transcription 3	Mus musculus	85-90
30914735-4	2019	ACEE also reduced the levels of JAK2 and phosphorylated STAT3 in LLC cells.	acee	0-4	signal transducer and activator of transcription 3	Mus musculus	56-61
30914735-8	2019	Our findings therefore indicate that ACEE inhibits lung tumor growth and metastasis by inducing apoptosis and by inhibiting the STAT3 signaling pathway in cancer cells.	acee	37-41	signal transducer and activator of transcription 3	Mus musculus	128-133
30909508-5	2019	Of note, the zoledronate treatment-induced upregulation of the RANKL expression was mediated by autocrine interleukin-6 (IL-6) and subsequent activation of the signal transducer and activator of transcription 3 (STAT3) pathway.	Zoledronic Acid	13-24	signal transducer and activator of transcription 3	Mus musculus	160-210
30909508-5	2019	Of note, the zoledronate treatment-induced upregulation of the RANKL expression was mediated by autocrine interleukin-6 (IL-6) and subsequent activation of the signal transducer and activator of transcription 3 (STAT3) pathway.	Zoledronic Acid	13-24	signal transducer and activator of transcription 3	Mus musculus	212-217
30909508-6	2019	These results were evidenced by the blunted RANKL expression in the presence of a Janus activated kinase (JAK2)/STAT3 inhibitor, AG490.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	129-134	signal transducer and activator of transcription 3	Mus musculus	112-117
30884843-6	2019	In addition, UDCA downregulated NF-kappaB and STAT3 phosphorylation by negative regulation of the expression of SOCS1 and SOCS3 signaling.	Ursodeoxycholic Acid	13-17	signal transducer and activator of transcription 3	Mus musculus	46-51
30660700-0	2019	Effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by mono-2-ethylhexyl phthalate.	mono-(2-ethylhexyl)phthalate	68-95	signal transducer and activator of transcription 3	Mus musculus	20-26
30660700-3	2019	The present study was performed to investigate the effect of the TYK-2/STAT-3 pathway on lipid accumulation induced by MEHP.	mono-(2-ethylhexyl)phthalate	119-123	signal transducer and activator of transcription 3	Mus musculus	71-77
30660700-10	2019	In addition, MEHP down-regulated the phosphorylation of STAT-3 in mitochondria.	mono-(2-ethylhexyl)phthalate	13-17	signal transducer and activator of transcription 3	Mus musculus	56-62
30660700-12	2019	CONCLUSION: MEHP may affect adipocyte differentiation and lead to lipid accumulation through the TYK-2/STAT-3 pathway.	mono-(2-ethylhexyl)phthalate	12-16	signal transducer and activator of transcription 3	Mus musculus	103-109
30865888-5	2019	Elevation of lactate activates AKT and STAT3 signaling in the hypothalamic neurons, leading to increased expression of Pomc and suppression of Agrp.	Lactic Acid	13-20	signal transducer and activator of transcription 3	Mus musculus	39-44
30668131-3	2019	The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappaB and STAT3.	Curcumin	28-36	signal transducer and activator of transcription 3	Mus musculus	166-171
30668131-3	2019	The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappaB and STAT3.	Celecoxib	47-56	signal transducer and activator of transcription 3	Mus musculus	166-171
30668131-3	2019	The combined application of curcumin (CUR) and celecoxib (CXB) has been proven to exert a synergistic antitumor effect via inhibiting the activation of NF-kappaB and STAT3.	Celecoxib	58-61	signal transducer and activator of transcription 3	Mus musculus	166-171
30430364-0	2019	Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3.	carnosol	21-29	signal transducer and activator of transcription 3	Mus musculus	76-81
30430364-10	2019	In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes.	carnosol	13-21	signal transducer and activator of transcription 3	Mus musculus	59-64
30553055-2	2019	We report here that caffeine markedly improved high fat diet-induced NAFLD in mice resulting in a 10-fold increase in circulating IL-6 levels, leading to STAT3 activation in the liver.	Caffeine	20-28	signal transducer and activator of transcription 3	Mus musculus	154-159
30553055-7	2019	The possibility that IL-6/STAT3-mediated hepatic autophagosome induction and hepatocytic oxygen consumption are involved in the anti-NAFLD effects of caffeine cannot be excluded, based on the findings presented here.	Caffeine	150-158	signal transducer and activator of transcription 3	Mus musculus	26-31
30553055-8	2019	Our results reveal that caffeine ameliorates NAFLD via crosstalk between muscle IL-6 production and liver STAT3 activation.	Caffeine	24-32	signal transducer and activator of transcription 3	Mus musculus	106-111
30572004-9	2019	In a similar manner, both Fut8-KO C6 cells and primary astrocytes treated with 2-fluoro-L-fucose, a specific inhibitor for fucosylation, showed a higher response to IL-6-stimulated phospho-STAT3 signaling, compared with WT cells.	2-fluoro-l-fucose	79-96	signal transducer and activator of transcription 3	Mus musculus	189-194
30593877-13	2019	Finally, AG490, a blocker of the JAK2/STAT3 pathway, could reverse the neuroprotective effects of Gap19 both in vivo and in vitro.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	9-14	signal transducer and activator of transcription 3	Mus musculus	38-43
30412932-6	2019	When neutrophils isolated from WT mice were treated with FlgE, the expression of IL17A/IL17RC was increased, but the activation was blocked by STAT3 inhibitor.	flge	57-61	signal transducer and activator of transcription 3	Mus musculus	143-148
30648776-9	2019	Our data showed that BAZ inhibited STAT3 phosphorylation (P-STAT3) and expression of STAT3 downstream genes, inducing apoptosis in liver cancer cells.	bazedoxifene	21-24	signal transducer and activator of transcription 3	Mus musculus	35-40
30648776-9	2019	Our data showed that BAZ inhibited STAT3 phosphorylation (P-STAT3) and expression of STAT3 downstream genes, inducing apoptosis in liver cancer cells.	bazedoxifene	21-24	signal transducer and activator of transcription 3	Mus musculus	60-65
30648776-9	2019	Our data showed that BAZ inhibited STAT3 phosphorylation (P-STAT3) and expression of STAT3 downstream genes, inducing apoptosis in liver cancer cells.	bazedoxifene	21-24	signal transducer and activator of transcription 3	Mus musculus	60-65
30648776-10	2019	BAZ inhibited P-STAT3 induced by IL-6, but not by leukemia inhibitory factor.	bazedoxifene	0-3	signal transducer and activator of transcription 3	Mus musculus	16-21
30648776-12	2019	In addition, pretreatment of BAZ impeded the translocation of STAT3 to nuclei induced by IL-6.	bazedoxifene	29-32	signal transducer and activator of transcription 3	Mus musculus	62-67
29942991-0	2019	Baicalin attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.	baicalin	0-8	signal transducer and activator of transcription 3	Mus musculus	70-75
29942991-9	2019	Our experiment indicate that CIA mice can be alleviated by Baicalin treatment via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.	baicalin	59-67	signal transducer and activator of transcription 3	Mus musculus	101-106
30269370-5	2019	Mutation of LepRb Tyr 1138 , which results in an inability to recruit and phosphorylate signal transducer and activator of transcription 3, also caused obesity, but bone loss and adiposity were more dominant in male mice and no growth defect was observed.	Tyrosine	18-21	signal transducer and activator of transcription 3	Mus musculus	88-138
30913116-9	2019	CONCLUSION: Dioscin may affect the differentiation of Th17 and Tregs and secretion of related factors by regulating CD4 T cell subset-related signal transduction and the expression of transcription-activating factor STAT3 and STAT5, thus exerting useful immunoregulatory roles in CIA mice.	dioscin	12-19	signal transducer and activator of transcription 3	Mus musculus	216-221
30618146-4	2019	They can show an increase in phosphorylated Stat-3 in the presence of leptin, are electrically excited by the anorectic neuromodulator cholecystokinin, and inhibited by orexigenic neuromodulators neuropeptide Y, met-enkephalin, dynorphin and the catecholamine dopamine.	Catecholamines	246-259	signal transducer and activator of transcription 3	Mus musculus	44-50
30618146-4	2019	They can show an increase in phosphorylated Stat-3 in the presence of leptin, are electrically excited by the anorectic neuromodulator cholecystokinin, and inhibited by orexigenic neuromodulators neuropeptide Y, met-enkephalin, dynorphin and the catecholamine dopamine.	Dopamine	260-268	signal transducer and activator of transcription 3	Mus musculus	44-50
30267577-6	2019	Furthermore, tranexamic acid treatment was observed to suppress increases in the plasma levels of matrix metalloproteinase-9 and interleukin (IL)-6, and skin expression of plasmin, CC chemokine 2, macrophages, signal transducer and activator of transcription (STAT)3, cyclin D and vascular endothelial growth factor (VEGF)-A that occurred in mice subjected to long-term UVA irradiation.	Tranexamic Acid	13-28	signal transducer and activator of transcription 3	Mus musculus	210-266
30899259-10	2019	In vitro recombinant mouse OSM induced tyrosine phosphorylation of the transcription factor STAT3, a downstream target of OSMR:gp130 signaling in muscle progenitor cells.	Tyrosine	39-47	signal transducer and activator of transcription 3	Mus musculus	92-97
30899259-11	2019	As STAT3 is tyrosine phosphorylated by JAK1/2 tyrosine kinases downstream of OSMR:gp130, we demonstrated that the JAK1/2 tyrosine kinase inhibitor ruxolitinib blocked OSM driven STAT3 tyrosine phosphorylation in mouse muscle progenitor cells.	Tyrosine	12-20	signal transducer and activator of transcription 3	Mus musculus	3-8
30899259-11	2019	As STAT3 is tyrosine phosphorylated by JAK1/2 tyrosine kinases downstream of OSMR:gp130, we demonstrated that the JAK1/2 tyrosine kinase inhibitor ruxolitinib blocked OSM driven STAT3 tyrosine phosphorylation in mouse muscle progenitor cells.	ruxolitinib	147-158	signal transducer and activator of transcription 3	Mus musculus	3-8
30899259-11	2019	As STAT3 is tyrosine phosphorylated by JAK1/2 tyrosine kinases downstream of OSMR:gp130, we demonstrated that the JAK1/2 tyrosine kinase inhibitor ruxolitinib blocked OSM driven STAT3 tyrosine phosphorylation in mouse muscle progenitor cells.	ruxolitinib	147-158	signal transducer and activator of transcription 3	Mus musculus	178-183
30899259-11	2019	As STAT3 is tyrosine phosphorylated by JAK1/2 tyrosine kinases downstream of OSMR:gp130, we demonstrated that the JAK1/2 tyrosine kinase inhibitor ruxolitinib blocked OSM driven STAT3 tyrosine phosphorylation in mouse muscle progenitor cells.	Tyrosine	46-54	signal transducer and activator of transcription 3	Mus musculus	3-8
30899259-12	2019	We further demonstrated in vivo that STAT3 tyrosine phosphorylation was not only significantly higher but persisted for a longer duration in injured muscles of SCI mice developing NHO compared to mice with muscle injury without SCI.	Tyrosine	43-51	signal transducer and activator of transcription 3	Mus musculus	37-42
30521107-9	2019	Mechanistically, GA inhibits ULK1 and activates autophagy, which induces the degradation of EGFR, gp130, and calcineurin A, thereby inhibiting the downstream signaling cascades (AKT, ERK1/2, JAK2/STAT3, and NFATc1).	Gallic Acid	17-19	signal transducer and activator of transcription 3	Mus musculus	196-201
30267577-7	2019	These results indicated that the nonmelanoma skin cancer induced by DMBA+UVA long-term irradiation is ameliorated by tranexamic acid through regulation of the plasmin/macrophage/IL-6/STAT3/cyclin D signal transmission pathway.	Tranexamic Acid	117-132	signal transducer and activator of transcription 3	Mus musculus	183-188
30685357-10	2019	These results uncover a novel role of BK and B2R cross-talk in KCs activation in TCE sensitized mice, mediated by pro-inflammatory cytokine release via MAPK and STAT3 activation, contributing to the immune liver injury.	Trichloroethylene	81-84	signal transducer and activator of transcription 3	Mus musculus	161-166
30683312-9	2019	In vitro studies found that Liraglutide treatment modulates Kupffer cells to M2-like activation via the cAMP-PKA-STAT3 signaling pathway.	Cyclic AMP	104-108	signal transducer and activator of transcription 3	Mus musculus	113-118
30683312-10	2019	The perilous effects of a high-fat diet were alleviated by liraglutide, including hepatic steatosis, by modulating Kupffer cells M2 polarization via the cAMP-PKA-STAT3 signaling pathway.	Cyclic AMP	153-157	signal transducer and activator of transcription 3	Mus musculus	162-167
30781690-0	2019	Astaxanthin Ameliorates Lipopolysaccharide-Induced Neuroinflammation, Oxidative Stress and Memory Dysfunction through Inactivation of the Signal Transducer and Activator of Transcription 3 Pathway.	astaxanthine	0-11	signal transducer and activator of transcription 3	Mus musculus	138-188
30781690-9	2019	We found that AXT directly bound to the DNA- binding domain (DBD) and linker domain (LD) domains of STAT3 using docking studies.	astaxanthine	14-17	signal transducer and activator of transcription 3	Mus musculus	100-105
31016114-7	2019	Furthermore, it is found that LDH@155 significantly decreases the expression level of phosphorylated STAT3 and ERK1/2 and activates NF-kappaB expression in TAMs, indicating that the STAT3, ERK1/2, and NF-kappaB signaling pathways may involve in LDH@155-induced macrophage polarization.	tams	156-160	signal transducer and activator of transcription 3	Mus musculus	101-106
31016114-7	2019	Furthermore, it is found that LDH@155 significantly decreases the expression level of phosphorylated STAT3 and ERK1/2 and activates NF-kappaB expression in TAMs, indicating that the STAT3, ERK1/2, and NF-kappaB signaling pathways may involve in LDH@155-induced macrophage polarization.	tams	156-160	signal transducer and activator of transcription 3	Mus musculus	182-187
30658076-0	2019	Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis.	Silicon Dioxide	95-101	signal transducer and activator of transcription 3	Mus musculus	74-79
30787420-5	2019	Pathway analysis of DEGs and DASGs reveal that NR1H4 may play an important role in ZINC24469384-induced anti-proliferation effect and is dramatically alleviated by down-regulating the SOCS2 expression and promoting STAT3 phosphorylation in knockdown NR1H4 HepG2 cells.	ZINC24469384	83-95	signal transducer and activator of transcription 3	Mus musculus	215-220
30658076-8	2019	Fyn and p-STAT3, as opposed to miR-125a-3p expression, were elevated in silica-induced fibrotic murine lung tissues and TGF-beta1-treated fibroblast lines.	Silicon Dioxide	72-78	signal transducer and activator of transcription 3	Mus musculus	10-15
30741923-4	2019	However, Stat3, but not RORgammat, has decreased polyubiquitination, as well as diminished tyrosine-705 activating phosphorylation.	Tyrosine	91-99	signal transducer and activator of transcription 3	Mus musculus	9-14
30767143-8	2019	Rotenone and H2O2 (100 microM, 4 h) treatment reduced STAT3 expression and activity in cardiomyocytes but not cardiac fibroblasts.	Rotenone	0-8	signal transducer and activator of transcription 3	Mus musculus	54-59
30767143-8	2019	Rotenone and H2O2 (100 microM, 4 h) treatment reduced STAT3 expression and activity in cardiomyocytes but not cardiac fibroblasts.	Hydrogen Peroxide	13-17	signal transducer and activator of transcription 3	Mus musculus	54-59
30767143-9	2019	Inhibition of STAT3 impaired mitochondrial respiratory capacity and exacerbated H2O2-induced cell injury in cardiomycytes but not significantly in cardiac fibroblasts.	Hydrogen Peroxide	80-84	signal transducer and activator of transcription 3	Mus musculus	14-19
30778300-3	2019	When mouse MG6 cells were stimulated with the TLR4 ligands lipopolysaccharide (LPS) and paclitaxel, we found that interferon regulatory factor 1 (IRF1) protein expression and activation was upregulated, transcription of interferon-beta (IFN-beta) was accelerated, induction/activation of STAT1 and activation of STAT3 were promoted, and subsequently iNOS expression was upregulated.	Paclitaxel	88-98	signal transducer and activator of transcription 3	Mus musculus	312-317
30329025-2	2019	We have recently reported that niclosamide treatment reduces growth and progression of endometriosis-like lesions and inflammatory signaling (NF${\rm \small K}$B and STAT3) in a mouse model.	Niclosamide	31-42	signal transducer and activator of transcription 3	Mus musculus	166-171
30797418-0	2019	Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway.	hesperetin	0-10	signal transducer and activator of transcription 3	Mus musculus	88-93
30797418-10	2019	Moreover, the expression of p-JAK2 and p-STAT3 were significantly decreased after stimulation with HDND-12 in M1-like macrophages.	hdnd-12	99-106	signal transducer and activator of transcription 3	Mus musculus	41-46
30840301-15	2019	In addition, the protein expression levels of Jak2 and STAT3 were obviously upregulated in IRI mice, which were significantly downregulated after 10 mg/kg NaB treatment.	nab	155-158	signal transducer and activator of transcription 3	Mus musculus	55-60
30779101-0	2019	Influence of roflumilast on sepsis mice through the JAK/STAT signaling pathway.	Roflumilast	13-24	signal transducer and activator of transcription 3	Mus musculus	56-60
30779101-1	2019	OBJECTIVE: The aim of this study was to explore the influence of roflumilast on sepsis mice through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway.	Roflumilast	65-76	signal transducer and activator of transcription 3	Mus musculus	171-175
30779101-19	2019	CONCLUSIONS: Roflumilast can improve lung tissue morphology of sepsis mice by inhibiting the JAK/STAT signaling pathway.	Roflumilast	13-24	signal transducer and activator of transcription 3	Mus musculus	97-101
30592974-0	2019	Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling.	Cocaine	100-107	signal transducer and activator of transcription 3	Mus musculus	158-163
30592974-3	2019	Cocaine-induced convulsive behaviors significantly increased GPx-1, p-IkB, and p-JAK2/STAT3 expression, and oxidative burdens in the hippocampus of mice.	Cocaine	0-7	signal transducer and activator of transcription 3	Mus musculus	86-91
30592974-4	2019	There was no significant difference in cocaine-induced p-IkB expression between non-transgenic (non-TG) and GPx-1 overexpressing transgenic (GPx-1 TG) mice, but significant differences were observed in cocaine-induced p-JAK2/STAT3 expression and oxidative stress between non-TG and GPx-1 TG mice.	Cocaine	202-209	signal transducer and activator of transcription 3	Mus musculus	225-230
30592974-7	2019	AG490, a JAK2/STAT3 inhibitor, but not pyrrolidone dithiocarbamate, an NFkappaB inhibitor, significantly counteracted GPx-1-mediated protective potentials (i.e., anticonvulsant-, antioxidant-, antiapoptotic-effects).	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-5	signal transducer and activator of transcription 3	Mus musculus	14-19
30592974-12	2019	Therefore, our results suggest that astrocytic modulation between GPx-1 and JAK2/STAT3 might be one of the underlying mechanisms for protecting against convulsive neurotoxicity induced by cocaine.	Cocaine	188-195	signal transducer and activator of transcription 3	Mus musculus	81-86
30896303-0	2019	Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via alpha7nAChR to inhibit inflammation in LPS-stimulated macrophages.	sinomenine	0-10	signal transducer and activator of transcription 3	Mus musculus	37-42
29935220-6	2019	RESULTS: IL-23 induces Ptgs2, encoding COX2 in TH17 cells, and produces PGE2, which acts back on the PGE receptors EP2 and EP4 in these cells and enhances IL-23-induced expression of an IL-23 receptor subunit gene, Il23r, by activating signal transducer and activator of transcription (STAT) 3, cAMP-responsive element binding protein 1, and nuclear factor kappa light chain enhancer of activated B cells (NF-kappaB) through cyclic AMP-protein kinase A signaling.	Dinoprostone	72-76	signal transducer and activator of transcription 3	Mus musculus	236-293
30305729-12	2019	Ruxolitinib-treated tumors in both the immunocompromised and immunocompetent animal models demonstrate decreased phospho-STAT3, indicating on-target activity.	ruxolitinib	0-11	signal transducer and activator of transcription 3	Mus musculus	121-126
30675314-0	2019	Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways.	Metformin	0-9	signal transducer and activator of transcription 3	Mus musculus	127-132
30675314-0	2019	Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways.	Doxorubicin	85-96	signal transducer and activator of transcription 3	Mus musculus	127-132
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Doxorubicin	199-210	signal transducer and activator of transcription 3	Mus musculus	55-105
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Doxorubicin	199-210	signal transducer and activator of transcription 3	Mus musculus	107-112
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Doxorubicin	212-215	signal transducer and activator of transcription 3	Mus musculus	55-105
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Doxorubicin	212-215	signal transducer and activator of transcription 3	Mus musculus	107-112
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	221-230	signal transducer and activator of transcription 3	Mus musculus	55-105
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	221-230	signal transducer and activator of transcription 3	Mus musculus	107-112
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	232-236	signal transducer and activator of transcription 3	Mus musculus	55-105
30675314-4	2019	Furthermore, it was identified that activations of the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signaling pathways in 4T1 TS conferred drug-resistance to doxorubicin (Dox) and lapatinib (Lapa).	Lapatinib	232-236	signal transducer and activator of transcription 3	Mus musculus	107-112
30675314-5	2019	However, Met selectively targeted TS rather than cells in monolayer culture and increased the cytotoxic effect of Dox on TS by inhibiting activations of the STAT3 and AKT signaling pathways.	Doxorubicin	114-117	signal transducer and activator of transcription 3	Mus musculus	157-162
30574980-4	2019	Moreover, theanine self-administration significantly attenuated inhibitions of JAK2/STAT3 phosphorylation, M1 mAChR expression, and ERK1/2 phosphorylation in the hippocampus of klotho mutant mice.	theanine	10-18	signal transducer and activator of transcription 3	Mus musculus	84-89
30574980-5	2019	Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	14-19	signal transducer and activator of transcription 3	Mus musculus	28-33
30574980-5	2019	Consistently, AG490, a JAK2/STAT3 inhibitor, dicyclomine, an M1 mAChR antagonist, or U0126, an ERK1/2 inhibitor, significantly counteracted theanine-induced attenuation of memory impairment induced by klotho gene depletion in mice.	theanine	140-148	signal transducer and activator of transcription 3	Mus musculus	28-33
30574980-6	2019	Our study suggests that theanine attenuates memory impairments in a genetic aging model via up-regulation of JAK2/STAT3, M1 mAChR, and ERK signaling.	theanine	24-32	signal transducer and activator of transcription 3	Mus musculus	114-119
30633770-12	2019	AAI treatment significantly increased renal p-MEK without increasing p-STAT3 and p-Smad3 levels, and p-MEK/p-ERK1/2 signalling pathway was significantly activated.	aristolochic acid I	0-3	signal transducer and activator of transcription 3	Mus musculus	71-76
30635550-4	2019	Vinpocetine decreased adipogenic cell signaling, including the phosphorylation of ERK, AKT, JAK2, and STAT3, and adipokine secretion, including IL-6, IL-10, and IFN-alpha.	vinpocetine	0-11	signal transducer and activator of transcription 3	Mus musculus	102-107
30551434-6	2019	In conclusion, PTE suppressed the activation of TGF-beta1/Smad3, Src and STAT3 signaling pathway to alleviate renal fibrosis of HN mice, highlighting that PTE was a potential antifibrotic strategy for hyperuricemic nephropathy.	pterostilbene	15-18	signal transducer and activator of transcription 3	Mus musculus	73-78
30444022-8	2019	As STAT3 inhibition reversed the effects of IL-6-treated microglial cells on the RPE monolayer in vitro, it reduced the recruitment of microglial cells and the production of TNF-alpha in RPE tissues in streptozotocin-treated mice.	Streptozocin	202-216	signal transducer and activator of transcription 3	Mus musculus	3-8
31054338-0	2019	Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3.	thymoquinone	0-12	signal transducer and activator of transcription 3	Mus musculus	105-110
31592599-20	2019	Inhibition of proteins involved in the JAK2/STAT3 signalling pathway reversed the effects observed after PNU stimulation.	N-neopentyl-N-nitrosourea	105-108	signal transducer and activator of transcription 3	Mus musculus	44-49
30481554-3	2019	This in vivo study aimed to determine the potential role of the transcription factor STAT3 in the rapamycin-mediated neuroprotection in a mouse model of SAH.	Sirolimus	98-107	signal transducer and activator of transcription 3	Mus musculus	85-90
30481554-10	2019	These data suggest that ERK and JAK/STAT3 pathways play an important role in the neurocardiac protection by rapamycin after SAH.	Sirolimus	108-117	signal transducer and activator of transcription 3	Mus musculus	36-41
30481554-11	2019	We propose that rapamycin is a novel pharmacological strategy to target STAT3 activation, with a possible crosstalk through the ERK pathway, for the treatment of post-SAH early brain injury.	Sirolimus	16-25	signal transducer and activator of transcription 3	Mus musculus	72-77
30426907-11	2019	This finding was also accompanied by a reduction in neuronal cell apoptosis and p-STAT3 transcription factor levels in the xuesaitong-treated group compared with the vehicle-treated group.	xuesetong	123-133	signal transducer and activator of transcription 3	Mus musculus	82-87
30472367-9	2019	Expression of AMP-activated protein kinase (AMPK) and signal transducers and activators of transcription 3 (STAT3) was restored by 7,8-DHF.	6,7-dihydroxyflavone	131-138	signal transducer and activator of transcription 3	Mus musculus	54-106
30472367-9	2019	Expression of AMP-activated protein kinase (AMPK) and signal transducers and activators of transcription 3 (STAT3) was restored by 7,8-DHF.	6,7-dihydroxyflavone	131-138	signal transducer and activator of transcription 3	Mus musculus	108-113
30472367-12	2019	The regulatory effects of 7,8-DHF on STAT3 and AMPK was reversed by Akt inhibitor.	6,7-dihydroxyflavone	26-33	signal transducer and activator of transcription 3	Mus musculus	37-42
30472367-13	2019	In summary, 7,8-DHF attenuated Dox-induced cardiotoxicity by activating Akt and increasing mitochondrial oxidative phosphorylation and thereby regulating STAT3, AMPK, and ERK signals.	6,7-dihydroxyflavone	12-19	signal transducer and activator of transcription 3	Mus musculus	154-159
30472367-13	2019	In summary, 7,8-DHF attenuated Dox-induced cardiotoxicity by activating Akt and increasing mitochondrial oxidative phosphorylation and thereby regulating STAT3, AMPK, and ERK signals.	Doxorubicin	31-34	signal transducer and activator of transcription 3	Mus musculus	154-159
31096217-14	2019	IL-6 and phospho-STAT3 (pSTAT3) expression, the downstream pathway of myostatin, were decreased by EPS and this was also reversed by flutamide.	Flutamide	133-142	signal transducer and activator of transcription 3	Mus musculus	17-22
30521964-13	2019	Furthermore, overexpression of THRIL enhanced the LPS-induced JAK1/STAT3 and NF-kappaB pathways activation by down-regulating miR-125b.	thril	31-36	signal transducer and activator of transcription 3	Mus musculus	67-72
30521964-15	2019	Overexpression of THRIL promoted LPS-induced ATDC5 cell inflammatory injury by down-regulating miR-125b and then activating JAK1/STAT3 and NF-kappaB pathways.	thril	18-23	signal transducer and activator of transcription 3	Mus musculus	129-134
30387806-8	2019	The results also indicated that TMP may decrease hepcidin expression via inhibition of Stat3 signaling.	tetramethylpyrazine	32-35	signal transducer and activator of transcription 3	Mus musculus	87-92
30337279-8	2018	Importantly, only the bifunctional CpG-STAT3ASO, but not control CpG oligonucleotides, STAT3ASO alone, or the coinjection of both oligonucleotides, succeeded in recruiting neutrophils and CD8+ T cells into tumors.	Oligonucleotides	130-146	signal transducer and activator of transcription 3	Mus musculus	39-47
32464007-0	2019	Restorative Effect of Fucoxanthin in an Ovalbumin-Induced Allergic Rhinitis Animal Model through NF-kappaB p65 and STAT3 Signaling.	fucoxanthin	22-33	signal transducer and activator of transcription 3	Mus musculus	115-120
32464007-9	2019	The present study showed that cytokine production, the induction of cell survival molecule NF-kappaB p65, and subsequent prevention of IkappaBalpha phosphorylation are controlled by fucoxanthin, and that interleukins (IL-5, IL-6, and IL-12) support STAT-3 binding to key elements that control IL-17A expression.	fucoxanthin	182-193	signal transducer and activator of transcription 3	Mus musculus	249-255
30602693-7	2018	Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway.	baicalein	44-53	signal transducer and activator of transcription 3	Mus musculus	100-105
30602693-7	2018	Furthermore, the hepatoprotective effect of baicalein to APAP-induced liver injury involved in Jak2/Stat3 and MAPK signaling pathway.	Acetaminophen	57-61	signal transducer and activator of transcription 3	Mus musculus	100-105
30562763-11	2018	Moreover, baicalin treatment induced cells apoptosis in synovial fluid monocytes and markedly down regulated JAK1/STAT3 but not mitogen-activated protein kinases (MAPKs) expressions in synovium of arthritis.	baicalin	10-18	signal transducer and activator of transcription 3	Mus musculus	114-119
30562763-15	2018	Moreover, the molecular mechanism implies suppressed JAK1/STAT3 signaling with baicalin treatment.	baicalin	79-87	signal transducer and activator of transcription 3	Mus musculus	58-63
30460722-0	2019	beta-carotene attenuates lipopolysaccharide-induced inflammation via inhibition of the NF-kappaB, JAK2/STAT3 and JNK/p38 MAPK signaling pathways in macrophages.	beta Carotene	0-13	signal transducer and activator of transcription 3	Mus musculus	103-108
30460722-2	2019	In this study, we investigated the influence of beta-carotene on the activation of JAK2/STAT3, MAPK, and NF-kappaB signaling pathway induced by LPS in RAW264.7 cells and peritoneal macrophages.	beta Carotene	48-61	signal transducer and activator of transcription 3	Mus musculus	88-93
30460722-6	2019	LPS-induced JAK2/STAT3, IkappaB/NF-kappaB p65, JNK/p38 MAPK signal activation were significantly attenuated (p &lt; 0.05) by beta-carotene in a dose-dependent manner.	beta Carotene	125-138	signal transducer and activator of transcription 3	Mus musculus	17-22
30460722-7	2019	In conclusion, beta-carotene could attenuate LPS-induced inflammation via inhibition of the NF-kappaB, JAK2/STAT3, and JNK/p38 MAPK signaling pathways in macrophages.	beta Carotene	15-28	signal transducer and activator of transcription 3	Mus musculus	108-113
30158673-8	2019	These findings represent a previously unrecognized link between STAT3 inhibition and Fas-induced apoptosis of MDSCs.	ammonium ferrous sulfate	85-88	signal transducer and activator of transcription 3	Mus musculus	64-69
30662576-14	2018	In vitro results also uncovered the similar alterations of SOCS3 and P-STAT3 in cardiomyocytes and cardiac fibroblasts induced by high glucose (HG).	Glucose	135-142	signal transducer and activator of transcription 3	Mus musculus	71-76
30518397-0	2018	The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.	Polyphenols	12-22	signal transducer and activator of transcription 3	Mus musculus	65-70
30518397-0	2018	The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.	Curcumin	23-31	signal transducer and activator of transcription 3	Mus musculus	65-70
30518397-3	2018	METHODS: Luciferase assay and immunoblotting were performed to examine whether curcumin suppressed STAT3 signaling.	Curcumin	79-87	signal transducer and activator of transcription 3	Mus musculus	99-104
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Polyphenols	21-31	signal transducer and activator of transcription 3	Mus musculus	51-56
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Polyphenols	21-31	signal transducer and activator of transcription 3	Mus musculus	93-98
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	51-56
30518397-11	2018	RESULTS: The natural polyphenol curcumin inhibited STAT3 phosphorylation rapidly and blocked STAT3-mediated signaling in ESCC cells.	Curcumin	32-40	signal transducer and activator of transcription 3	Mus musculus	93-98
30518397-13	2018	Furthermore, curcumin preferentially blocked the growth of primary ESCC-derived xenografts that harbored activated STAT3.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	115-120
30518397-14	2018	CONCLUSIONS: Curcumin is able to exert anti-tumor action through inhibiting the STAT3 signaling pathway.	Curcumin	13-21	signal transducer and activator of transcription 3	Mus musculus	80-85
30518397-15	2018	Giving its wide use in traditional medicines with low toxicity and few adverse reactions, it is conceivable that curcumin might be further explored as a unique STAT3 inhibitor for anti-cancer therapies.	Curcumin	113-121	signal transducer and activator of transcription 3	Mus musculus	160-165
29752696-0	2018	Total Saponins of Rubus Parvifolius L. Exhibited Anti-Leukemia Effect in vivo through STAT3 and eIF4E Signaling Pathways.	Saponins	6-14	signal transducer and activator of transcription 3	Mus musculus	86-91
29947255-0	2018	Adiponectin Attenuates Oxygen-Glucose Deprivation-Induced Mitochondrial Oxidative Injury and Apoptosis in Hippocampal HT22 Cells via the JAK2/STAT3 Pathway.	oxygen-glucose	23-37	signal transducer and activator of transcription 3	Mus musculus	142-147
30172039-16	2018	Moreover, dysregulation of iron homeostasis may be due to MC-LR-induced Hamp1 downregulation, possibly mediated by hypoxia or the IL6-STAT3 and BMP-SMAD signaling pathways.	Iron	27-31	signal transducer and activator of transcription 3	Mus musculus	134-139
30172039-16	2018	Moreover, dysregulation of iron homeostasis may be due to MC-LR-induced Hamp1 downregulation, possibly mediated by hypoxia or the IL6-STAT3 and BMP-SMAD signaling pathways.	cyanoginosin LR	58-63	signal transducer and activator of transcription 3	Mus musculus	134-139
30515094-13	2018	Results: In vivo experiments confirmed that paeonol restricted atherosclerosis development and increased miR-223 expression, inhibited STAT3 pathway in ApoE-/- mice.	paeonol	44-51	signal transducer and activator of transcription 3	Mus musculus	135-140
30575930-15	2018	Meanwhile, the mRNA and protein levels of IL-9, sIL-9R, and p-STAT3 in the PBS group were also remarkably higher than those of the IL-9 antibody group.	pbs	75-78	signal transducer and activator of transcription 3	Mus musculus	62-67
30272260-0	2018	LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-alpha, PPAR-gamma, STAT-3, FAS, ACC, perilipin A, and AMPK.	LY3009120	0-9	signal transducer and activator of transcription 3	Mus musculus	155-161
30272260-9	2018	LY3009120 reduced not only the expression of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), and perilipin A, but also reduced the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells.	LY3009120	0-9	signal transducer and activator of transcription 3	Mus musculus	274-324
30272260-9	2018	LY3009120 reduced not only the expression of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), and perilipin A, but also reduced the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells.	LY3009120	0-9	signal transducer and activator of transcription 3	Mus musculus	326-332
30272260-11	2018	In summary, this is the first report, to the best of our knowledge, demonstrating that LY3009120 has an anti-adipogenic effect on 3T3-L1 cells, which may be mediated through control of the expression and phosphorylation of C/EBP-alpha, PPAR-gamma, STAT-3, FAS, ACC, perilipin A, and AMPK.	LY3009120	87-96	signal transducer and activator of transcription 3	Mus musculus	248-254
30129110-13	2018	ESA inhibited the level of JAK3, phosphorylation of Stat5 and Stat3, and Foxp3 in EL4 cells.	esa	0-3	signal transducer and activator of transcription 3	Mus musculus	62-67
30129110-14	2018	The suppressive effects of ESA on Foxp3 were attenuated by forced expression of Stat5 and Stat3.	esa	27-30	signal transducer and activator of transcription 3	Mus musculus	90-95
30132163-10	2018	Notably, inhibition of ER stress reversed the OXA-mediated inhibition of STAT3 activity and MGMT expression in the tumor cells.	Oxaliplatin	46-49	signal transducer and activator of transcription 3	Mus musculus	73-78
30251457-6	2018	The STAT3 pathway was activated in adipose and hepatic tissues in positive control, and inhibited in groups treated with gemfibrozil and fenofibrate.	Gemfibrozil	121-132	signal transducer and activator of transcription 3	Mus musculus	4-9
30251457-6	2018	The STAT3 pathway was activated in adipose and hepatic tissues in positive control, and inhibited in groups treated with gemfibrozil and fenofibrate.	Fenofibrate	137-148	signal transducer and activator of transcription 3	Mus musculus	4-9
30251457-8	2018	In 3T3-L1 adipogenic stem cells treated with high glucose, STAT3 knockdown greatly decreased the number of lipid droplets.	Glucose	50-57	signal transducer and activator of transcription 3	Mus musculus	59-64
30336422-0	2018	Oleoylethanolamide alleviates macrophage formation via AMPK/PPARalpha/STAT3 pathway.	oleoylethanolamide	0-18	signal transducer and activator of transcription 3	Mus musculus	70-75
30336422-8	2018	The underlying mechanism of OEA suppressing monocyte migration in the co-culture system was that OEA increased phosphorylation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARalpha) level, and decreased phosphorylation of signal transducer and activator of transcription 3 (STAT3) and monocyte chemoattractant protein-1 (MCP-1) level in macrophages, which was reinforced by the in vivo experiment.	oleoylethanolamide	28-31	signal transducer and activator of transcription 3	Mus musculus	271-321
30336422-8	2018	The underlying mechanism of OEA suppressing monocyte migration in the co-culture system was that OEA increased phosphorylation of AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPARalpha) level, and decreased phosphorylation of signal transducer and activator of transcription 3 (STAT3) and monocyte chemoattractant protein-1 (MCP-1) level in macrophages, which was reinforced by the in vivo experiment.	oleoylethanolamide	28-31	signal transducer and activator of transcription 3	Mus musculus	323-328
30532628-4	2018	Lipid-substituted polyethylenimine (PEI)-p-STAT3-siRNA were prepared and characterized by measuring its N/P ratio, zeta potential, size, association and dissociation with siRNA.	Polyethyleneimine	18-34	signal transducer and activator of transcription 3	Mus musculus	43-48
30532628-4	2018	Lipid-substituted polyethylenimine (PEI)-p-STAT3-siRNA were prepared and characterized by measuring its N/P ratio, zeta potential, size, association and dissociation with siRNA.	pei)-p	36-42	signal transducer and activator of transcription 3	Mus musculus	43-48
30532628-5	2018	B16.F10 melanoma cells were treated with six different concentrations of PEI-p-STAT3-siRNA (200, 100, 50, 25, 12.5 and 6.25 nM).	pei-p	73-78	signal transducer and activator of transcription 3	Mus musculus	79-84
30474622-12	2018	In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation.	Diethylnitrosamine	7-10	signal transducer and activator of transcription 3	Mus musculus	84-89
30474622-12	2018	In the DEN-treated mice, AICAR treatment reduced tumorigenesis, IL-6 signaling, and STAT3 activation.	AICA ribonucleotide	25-30	signal transducer and activator of transcription 3	Mus musculus	84-89
30523271-4	2018	Moreover, the suppressed IL-6 levels down regulated JAK2/STAT3 pathway with decrease inflammation-mediated Hamp mRNA transcription (HepG2) and increase iron absorption (Caco2) in HepG2/Caco2 co-culture model.	caco2	169-174	signal transducer and activator of transcription 3	Mus musculus	57-62
30450834-12	2018	CONCLUSION: Knocking down lncRNA GAS5 alleviated H2 O 2 -induced injury in PRGCs via upregulation of miR-124, which might dependent on activation of JAK/STAT3 signaling pathway and inhibition of JNK signaling pathway.	Hydrogen Peroxide	49-55	signal transducer and activator of transcription 3	Mus musculus	153-158
30429494-9	2018	Our results suggest that corticotomy induces macrophage polarization first by activating the NF-kappaB signaling pathway and later by activating the JAK/STAT3 signaling pathway, and that these processes contribute to OTM by triggering production of inflammatory cytokines and osteoclastogenesis.	corticotomy	25-36	signal transducer and activator of transcription 3	Mus musculus	153-158
30429582-3	2018	Galantamine verified its anti-inflammatory effect by elevating acetylcholine (ACh) level, while abating the interleukin-6/ janus kinase 2 (Y1007/1008)/ signal transducer and activator of transcription 3 (Y705) (IL-6/ pY(1007/1008)-JAK2/ pY705-STAT3) inflammatory axis, with a consequent inhibition in suppressor of cytokine signaling 3 (SOCS3).	Galantamine	0-11	signal transducer and activator of transcription 3	Mus musculus	152-202
30429582-3	2018	Galantamine verified its anti-inflammatory effect by elevating acetylcholine (ACh) level, while abating the interleukin-6/ janus kinase 2 (Y1007/1008)/ signal transducer and activator of transcription 3 (Y705) (IL-6/ pY(1007/1008)-JAK2/ pY705-STAT3) inflammatory axis, with a consequent inhibition in suppressor of cytokine signaling 3 (SOCS3).	Galantamine	0-11	signal transducer and activator of transcription 3	Mus musculus	243-248
30555566-0	2018	miR-125a-5p ameliorates hepatic glycolipid metabolism disorder in type 2 diabetes mellitus through targeting of STAT3.	mir-125a-5p	0-11	signal transducer and activator of transcription 3	Mus musculus	112-117
30413072-4	2018	OP-D exhibited substantial suppressive activity on STAT3 signaling and this effect was found to be mediated via oxidative stress phenomena caused by disturbance in GSH/GSSG ratio.	Glutathione Disulfide	168-172	signal transducer and activator of transcription 3	Mus musculus	51-56
30413072-8	2018	Our findings suggest that OP-D can induce apoptosis and exert anti-tumor effects by inhibition of STAT3 signaling pathways in NSCLC.	ophiopogonin D	26-30	signal transducer and activator of transcription 3	Mus musculus	98-103
30555566-4	2018	Through gain- and loss-of-function studies, the effects of miR-125a-5p via targeting of STAT3 on regulating glycolipid metabolism were further illustrated in vitro and in vivo.	Glycolipids	108-118	signal transducer and activator of transcription 3	Mus musculus	88-93
30555566-10	2018	In palmitic acid-induced AML12 cells, miR-125a-5p mimic markedly increased glucose consumption and uptake and decreased the accumulation of lipid droplets by regulating STAT3 signaling pathway.	Palmitic Acid	3-16	signal transducer and activator of transcription 3	Mus musculus	169-174
30555566-11	2018	Consistently, miR-125a-5p overexpression obviously inhibited STAT3 expression in diabetic KK-Ay mice, thereby decreasing blood glucose and lipid levels, increasing hepatic glycogen content, and decreasing accumulation of hepatic lipid droplets in diabetic mice.	Glucose	127-134	signal transducer and activator of transcription 3	Mus musculus	61-66
30555566-11	2018	Consistently, miR-125a-5p overexpression obviously inhibited STAT3 expression in diabetic KK-Ay mice, thereby decreasing blood glucose and lipid levels, increasing hepatic glycogen content, and decreasing accumulation of hepatic lipid droplets in diabetic mice.	Glycogen	172-180	signal transducer and activator of transcription 3	Mus musculus	61-66
30555566-13	2018	Conclusions: Our results confirmed that miR-125a-5p should be considered as a regulator of glycolipid metabolism in T2DM, which can inhibit hepatic lipogenesis and gluconeogenesis and elevate glycogen synthesis by targeting STAT3.	Glycolipids	91-101	signal transducer and activator of transcription 3	Mus musculus	224-229
30555566-13	2018	Conclusions: Our results confirmed that miR-125a-5p should be considered as a regulator of glycolipid metabolism in T2DM, which can inhibit hepatic lipogenesis and gluconeogenesis and elevate glycogen synthesis by targeting STAT3.	Glycogen	192-200	signal transducer and activator of transcription 3	Mus musculus	224-229
29683527-6	2018	However, these inhibitors caused a significant reduction in mast cell exocytosis and cytokine release, due to a decrease in OXPHOS activity and STAT3 serine 727 phosphorylation.	Serine	150-156	signal transducer and activator of transcription 3	Mus musculus	144-149
30400620-7	2018	Experimental results demonstrated that dietary supplementation of EGCG significantly inhibited HFD-induced obesity by enhancing BAT thermogenesis, and attenuated the hypothalamic inflammation and microglia overactivation by regulating the NF-kappaB and STAT3 signaling pathways.	epigallocatechin gallate	66-70	signal transducer and activator of transcription 3	Mus musculus	253-258
30184329-6	2018	The enhanced phosphorylation of STAT3 and NF-kappaB following DSS administration is mitigated by Hyp, which is also observed in LPS-treated RAW264.7 macrophages.	Dextran Sulfate	62-65	signal transducer and activator of transcription 3	Mus musculus	32-37
30257404-7	2018	Furthermore, the dual-luciferase reporter assay confirmed that miR-129-5p could bind directly to both PCGEM1 and STAT3.	mir-129-5p	63-73	signal transducer and activator of transcription 3	Mus musculus	113-118
30165128-4	2018	Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression.	Chlorogenic Acid	13-16	signal transducer and activator of transcription 3	Mus musculus	184-234
30165128-4	2018	Furthermore, ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression.	Chlorogenic Acid	13-16	signal transducer and activator of transcription 3	Mus musculus	236-241
30240636-0	2018	Cucurbitacin E ameliorates acute graft-versus-host disease by modulating Th17 cell subsets and inhibiting STAT3 activation.	cucurbitacin E	0-14	signal transducer and activator of transcription 3	Mus musculus	106-111
30247637-13	2018	Forty-eight hour inhibition of JAK1 with Ruxolitinib of PND2 ovaries in vitro demonstrated concomitant acceleration of primordial follicle activation and apoptosis (P &lt;= 0.001) and upregulation of downstream JAK-STAT pathway members STAT3 and suppressors of cytokine signalling 4 (SOCS4).	ruxolitinib	41-52	signal transducer and activator of transcription 3	Mus musculus	236-241
30227151-9	2018	GW0742 attenuated the expression of inflammatory markers such as IL-17A, RORgammaT, Stat3, TIM-3, and IFN-gamma, while upregulating anti-inflammatory markers such as IL-10/Foxp3 both in the brain and periphery of BTBR mice.	GW0742	0-6	signal transducer and activator of transcription 3	Mus musculus	84-89
29967195-9	2018	Inhibition of STAT3 tyrosine phosphorylation suppressed IL-10-induced expression of intracellular galectin-3 and transcriptional activation of Spp1.	Tyrosine	20-28	signal transducer and activator of transcription 3	Mus musculus	14-19
30374077-5	2018	By contrast, the overexpression of Ido2 in the murine macrophage cell line (RAW) suppressed cytokine production and decreased stat3 expression.	ido2	35-39	signal transducer and activator of transcription 3	Mus musculus	126-131
30374077-7	2018	These results reveal that Ido2 modulates IL-6/stat3 signalling and is induced by LPS, providing novel options for the treatment of immune disorders.	ido2	26-30	signal transducer and activator of transcription 3	Mus musculus	46-51
30498394-0	2018	Chemopreventive Effects of Silibinin on Colitis-Associated Tumorigenesis by Inhibiting IL-6/STAT3 Signaling Pathway.	Silybin	27-36	signal transducer and activator of transcription 3	Mus musculus	92-97
30498394-16	2018	Furthermore, STAT3 phosphorylation was significantly suppressed by silibinin.	Silybin	67-76	signal transducer and activator of transcription 3	Mus musculus	13-18
30498394-17	2018	In conclusion, silibinin could protect against colitis-associated tumorigenesis in mice via inhibiting IL-6/STAT3, which showed promising chemopreventive potential of CAC.	Silybin	15-24	signal transducer and activator of transcription 3	Mus musculus	108-113
30221419-6	2018	Moreover, 5(OH)Trp significantly inhibited keratinocyte activation with decrease in IL-6 production and p-Erk1/2 and p-STAT3 expression.	5(oh)trp	10-18	signal transducer and activator of transcription 3	Mus musculus	119-124
30145467-0	2018	BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.	bf211	0-5	signal transducer and activator of transcription 3	Mus musculus	117-122
30145467-7	2018	Furthermore, BF211 suppressed the phosphorylation of JAK2 and STAT3 both in vivo and in vitro.	bf211	13-18	signal transducer and activator of transcription 3	Mus musculus	62-67
30044759-4	2018	We used AG490 to inhibit the JAK2/STAT3 signaling in a mice bone marrow stromal cells (BMSCs) culture.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	8-13	signal transducer and activator of transcription 3	Mus musculus	34-39
30044759-11	2018	Moreover, AG490 inhibited phosphorylation of STAT3, P38, JNK and AKT.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	10-15	signal transducer and activator of transcription 3	Mus musculus	45-50
30459603-8	2018	In addition, MG132 supplementation markedly abrogated the impacts of icariin on ER stress and TXNIP-mediated downstream events such as inflammation and STAT3 phosphorylation.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	13-18	signal transducer and activator of transcription 3	Mus musculus	152-157
29981830-0	2018	Hydrogen sulfide inhibits ATP-induced neuroinflammation and Abeta1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.	Hydrogen Sulfide	0-16	signal transducer and activator of transcription 3	Mus musculus	113-118
30309372-12	2018	CA140 significantly downregulated LPS-induced phosphorylation of ERK and STAT3 in BV2 microglia cells.	ca140	0-5	signal transducer and activator of transcription 3	Mus musculus	73-78
30228000-0	2018	Andrographolide derivative as STAT3 inhibitor that protects acute liver damage in mice.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	30-35
30228000-3	2018	We synthesized a series of andrographolide derivatives, and characterized their activity against STAT3 signaling pathway both in vitro and in the CCl4-induced acute liver damage mice model.	andrographolide	27-42	signal transducer and activator of transcription 3	Mus musculus	97-102
29981830-0	2018	Hydrogen sulfide inhibits ATP-induced neuroinflammation and Abeta1-42 synthesis by suppressing the activation of STAT3 and cathepsin S.	Adenosine Triphosphate	26-29	signal transducer and activator of transcription 3	Mus musculus	113-118
29981830-6	2018	Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP.	Adenosine Triphosphate	36-39	signal transducer and activator of transcription 3	Mus musculus	113-163
29981830-6	2018	Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP.	Adenosine Triphosphate	36-39	signal transducer and activator of transcription 3	Mus musculus	165-170
29981830-6	2018	Thereafter, we found that exogenous ATP-induced inflammation and Abeta1-42 production requires the activation of signal transducer and activator of transcription 3 (STAT3) and cathepsin S (Cat S) as inhibition of the activity of either proteins attenuated the effect of exogenous ATP.	Adenosine Triphosphate	280-283	signal transducer and activator of transcription 3	Mus musculus	113-163
29981830-7	2018	Intriguingly, NaHS suppressed exogenous ATP-induced phosphorylation of STAT3 and the activation of Cat S.	sodium bisulfide	14-18	signal transducer and activator of transcription 3	Mus musculus	71-76
29981830-7	2018	Intriguingly, NaHS suppressed exogenous ATP-induced phosphorylation of STAT3 and the activation of Cat S.	Adenosine Triphosphate	40-43	signal transducer and activator of transcription 3	Mus musculus	71-76
29981830-10	2018	Taken together, our data provide a novel understanding of H2S-mediated effect on neuroinflammation and Abeta1-42 production by suppressing the activation of STAT3 and Cat S.	Deuterium	58-61	signal transducer and activator of transcription 3	Mus musculus	157-162
29914872-2	2018	In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (ThrbPV/PVPten+/- mice).	thrbpv	209-215	signal transducer and activator of transcription 3	Mus musculus	157-162
29751177-8	2018	Furthermore, treatment with AG-490, an inhibitor of JAK family kinases, suppressed activation of the IL-6/JAK2/STAT3 signaling cascade, in turn resulting in a decreased number of plasma cells in the mammary gland and reversing the pathogenesis of PCM.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	28-34	signal transducer and activator of transcription 3	Mus musculus	111-116
29914872-5	2018	We recently showed that inhibition of STAT3 activity by a specific inhibitor markedly delays thyroid cancer progression in high-fat-diet-induced obese ThrbPV/PVPten+/- mice (HFD-ThrbPV/PVPten+/- mice).	thrbpv	151-157	signal transducer and activator of transcription 3	Mus musculus	38-43
29914872-5	2018	We recently showed that inhibition of STAT3 activity by a specific inhibitor markedly delays thyroid cancer progression in high-fat-diet-induced obese ThrbPV/PVPten+/- mice (HFD-ThrbPV/PVPten+/- mice).	thrbpv	178-184	signal transducer and activator of transcription 3	Mus musculus	38-43
30327657-8	2018	Likewise, Th17 regulator proteins RORgammat, p-STAT3, and Ac-STAT3 were also inhibited by naringenin.	naringenin	90-100	signal transducer and activator of transcription 3	Mus musculus	47-52
30327657-8	2018	Likewise, Th17 regulator proteins RORgammat, p-STAT3, and Ac-STAT3 were also inhibited by naringenin.	naringenin	90-100	signal transducer and activator of transcription 3	Mus musculus	61-66
29959623-5	2018	More, AS significantly reduced the protein expression of JAK3/STAT3/NF-kappaB pathway in CS-induced mice.	Cesium	89-91	signal transducer and activator of transcription 3	Mus musculus	62-67
30144531-6	2018	Fasting increased SirT1 protein in STAT3 immunoprecipitation products and less in the liver of baicalin-treated mice, indicating that baicalin blocked the binding of SirT1 to STAT3 and thus preserved STAT3 acetylation.	baicalin	134-142	signal transducer and activator of transcription 3	Mus musculus	35-40
30144531-6	2018	Fasting increased SirT1 protein in STAT3 immunoprecipitation products and less in the liver of baicalin-treated mice, indicating that baicalin blocked the binding of SirT1 to STAT3 and thus preserved STAT3 acetylation.	baicalin	134-142	signal transducer and activator of transcription 3	Mus musculus	175-180
30144531-6	2018	Fasting increased SirT1 protein in STAT3 immunoprecipitation products and less in the liver of baicalin-treated mice, indicating that baicalin blocked the binding of SirT1 to STAT3 and thus preserved STAT3 acetylation.	baicalin	134-142	signal transducer and activator of transcription 3	Mus musculus	175-180
30144531-7	2018	SirT1 knockdown enhanced the protective effect of baicalin on pyruvate-induced STAT3 phosphorylation and acetylation, these results further indicated that the regulation of STAT3 activity by baicalin was dependent on SirT1.	Pyruvic Acid	62-70	signal transducer and activator of transcription 3	Mus musculus	79-84
30144531-7	2018	SirT1 knockdown enhanced the protective effect of baicalin on pyruvate-induced STAT3 phosphorylation and acetylation, these results further indicated that the regulation of STAT3 activity by baicalin was dependent on SirT1.	Pyruvic Acid	62-70	signal transducer and activator of transcription 3	Mus musculus	173-178
30144531-9	2018	SirT1 overexpression and STAT3 inhibition enhanced pyruvate-mediated PGC-1alpha gene expression, suggesting that deacetylation of STAT3 by SirT1 is required for PGC-1alpha activity on hepatic gluconeogenesis.	Pyruvic Acid	51-59	signal transducer and activator of transcription 3	Mus musculus	25-30
30144531-9	2018	SirT1 overexpression and STAT3 inhibition enhanced pyruvate-mediated PGC-1alpha gene expression, suggesting that deacetylation of STAT3 by SirT1 is required for PGC-1alpha activity on hepatic gluconeogenesis.	Pyruvic Acid	51-59	signal transducer and activator of transcription 3	Mus musculus	130-135
30231870-12	2018	In addition, ibrutinib significantly decreased LPS-induced increases in p-AKT and p-STAT3 levels, suggesting that ibrutinib attenuates LPS-induced neuroinflammatory responses by inhibiting AKT/STAT3 signaling pathways.	ibrutinib	13-22	signal transducer and activator of transcription 3	Mus musculus	84-89
30283437-8	2018	Furthermore, AhR-associated Src activity was responsible for tyrosine phosphorylation of STAT3 and IL-10 expression by inflammatory macrophages.	Tyrosine	61-69	signal transducer and activator of transcription 3	Mus musculus	89-94
30231870-12	2018	In addition, ibrutinib significantly decreased LPS-induced increases in p-AKT and p-STAT3 levels, suggesting that ibrutinib attenuates LPS-induced neuroinflammatory responses by inhibiting AKT/STAT3 signaling pathways.	ibrutinib	13-22	signal transducer and activator of transcription 3	Mus musculus	193-198
30231870-12	2018	In addition, ibrutinib significantly decreased LPS-induced increases in p-AKT and p-STAT3 levels, suggesting that ibrutinib attenuates LPS-induced neuroinflammatory responses by inhibiting AKT/STAT3 signaling pathways.	ibrutinib	114-123	signal transducer and activator of transcription 3	Mus musculus	84-89
30231870-12	2018	In addition, ibrutinib significantly decreased LPS-induced increases in p-AKT and p-STAT3 levels, suggesting that ibrutinib attenuates LPS-induced neuroinflammatory responses by inhibiting AKT/STAT3 signaling pathways.	ibrutinib	114-123	signal transducer and activator of transcription 3	Mus musculus	193-198
30075176-5	2018	Our aim was to determine whether O-GlcNAc promotes the inhibition of IL-10-pathway (JAK1/STAT3/IL-10), inactivationg its action in the vasculature.	o-glcnac	33-41	signal transducer and activator of transcription 3	Mus musculus	89-94
30075176-9	2018	KEY FINDINGS: High levels of O-GlcNAc, induced by Thiamet G incubation, increased vascular expression of JAK1, but decreased expression and activity of STAT3.	o-glcnac	29-37	signal transducer and activator of transcription 3	Mus musculus	152-157
30206377-6	2018	Innovative CARS (Coherent Anti-Stokes Raman Scattering) microscopy revealed that chemical inhibition of STAT3 activity decreased lipid accumulation and deregulated STAT3-responsive microRNAs, including miR-21, in lipid overloaded dHepaRG cells.	dheparg	230-237	signal transducer and activator of transcription 3	Mus musculus	104-109
30206377-7	2018	We were able to show in vivo that reducing phospho-STAT3-miR-21 levels in C57/BL6 mice liver, by long-term treatment with metformin, protected mice from aging-dependent hepatic vesicular steatosis.	Metformin	122-131	signal transducer and activator of transcription 3	Mus musculus	51-56
30254684-4	2018	Through genotyping, deletion of STAT3 alleles was detected in InSTAT3 KO ESCs following 24 hours Dox stimulation.	Doxycycline	97-100	signal transducer and activator of transcription 3	Mus musculus	32-37
29885836-4	2018	STAT3 was activated in MRL/lpr mice (a mouse model of lupus nephritis), and treatment with S3I-201 inhibited the activation of it.	NSC 74859	91-98	signal transducer and activator of transcription 3	Mus musculus	0-5
30254684-5	2018	Western blot also showed that pSTAT3 and STAT3 protein levels were significantly reduced in InSTAT3 KO ESCs while dominantly elevated in InSTAT3 CA ECSs upon Dox stimulation.	Doxycycline	158-161	signal transducer and activator of transcription 3	Mus musculus	31-36
29908007-0	2018	CoCl2 , a mimic of hypoxia, enhances bone marrow mesenchymal stem cells migration and osteogenic differentiation via STAT3 signaling pathway.	cobaltous chloride	0-5	signal transducer and activator of transcription 3	Mus musculus	117-122
30015838-11	2018	Notably, pimozide may regulate tumour immunity through inhibiting the activities of signal transducer and activator of transcription (Stat)3 and Stat5.	Pimozide	9-17	signal transducer and activator of transcription 3	Mus musculus	84-140
29800237-11	2018	We also found evidence that nitric oxide (NO) inhibits formation of intermediate monocytes and STAT3 activation.	Nitric Oxide	28-40	signal transducer and activator of transcription 3	Mus musculus	95-100
30186451-0	2018	Andrographolide attenuates viral myocarditis through interactions with the IL-10/STAT3 and P13K/AKT/NF-kappabeta signaling pathways.	andrographolide	0-15	signal transducer and activator of transcription 3	Mus musculus	81-86
30186451-6	2018	Effects of andrographolide on the expression of L-10, STAT3, NF-kappabeta p65 and NF-kappabeta p50 were investigated by western blot analysis.	andrographolide	11-26	signal transducer and activator of transcription 3	Mus musculus	54-59
30186451-7	2018	Results indicated that andrographolide treatment reduced serum levels of TNF-alpha, hs-CRP and cTnl, increased the expression levels of IL-10 and STAT3 and reduced the expression levels of NF-kappabeta p65 and NF-kappabeta p50 and the phosphorylation levels of phosphoinositide 3-kinase (P13K) and AKT in the heart tissues of mice with VMC.	andrographolide	23-38	signal transducer and activator of transcription 3	Mus musculus	146-151
30186451-9	2018	Therefore, it was concluded that andrographolide may inhibit the progression of VMC by interacting with the IL-10/STAT3 and NF-kappabeta signaling pathways.	andrographolide	33-48	signal transducer and activator of transcription 3	Mus musculus	114-119
30026270-7	2018	These anti-inflammatory effects of GSK3 inhibition were found to be driven, at least in part, by inhibiting production of apoptosis inhibitor of macrophage in macrophages via inactivating STAT3 to reduce free fatty acid and chemokine level produced from VAT to suppress the migration/chemotaxis of macrophages and monocytes.	Fatty Acids, Nonesterified	204-219	signal transducer and activator of transcription 3	Mus musculus	188-193
29244196-14	2018	These results show that iron overload generates ROS, blocks the PI3K/AKT and Jak/Stat3 signal pathways, and activates p38 MAPK, subsequently inducing G1 arrest and autophagy in MC3T3-E1 cells.	Iron	24-28	signal transducer and activator of transcription 3	Mus musculus	81-86
29684478-11	2018	In addition, vitamin D deficiency activated prostatic STAT3, a proliferation pathway in middle-aged mice.	Vitamin D	13-22	signal transducer and activator of transcription 3	Mus musculus	54-59
30143645-6	2018	Deficiency of TRIM27 significantly impairs dextran sulfate sodium (DSS)-induced STAT3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice.	Dextran Sulfate	43-65	signal transducer and activator of transcription 3	Mus musculus	80-85
30064075-12	2018	CONCLUSION: Indirubin alleviates IMQ-induced psoriasis-like dermatitis mainly through reducing the inflammatory responses mediated by IL-17 A-producing gammadelta T cells involving Jak3/Stat3 activation.	Imiquimod	33-36	signal transducer and activator of transcription 3	Mus musculus	186-191
30143645-6	2018	Deficiency of TRIM27 significantly impairs dextran sulfate sodium (DSS)-induced STAT3 activation, inflammatory cytokine expression and colitis as well as azoxymethane (AOM)/DSS-induced colitis-associated cancer in mice.	Dextran Sulfate	67-70	signal transducer and activator of transcription 3	Mus musculus	80-85
30181918-0	2018	T Cell-Specific Knockout of STAT3 Ameliorates Dextran Sulfate Sodium-Induced Colitis by Reducing the Inflammatory Response.	Dextran Sulfate	46-68	signal transducer and activator of transcription 3	Mus musculus	28-33
30224899-8	2018	Icaritin can also downregulate the expression of bone marrow TPO, myeloproliferative leukemia virus oncogene (MPL), and p-Stat3.	icaritin	0-8	signal transducer and activator of transcription 3	Mus musculus	122-127
30224899-9	2018	Our results suggest that icaritin can significantly improve the health of mice with ITP via possible downregulation of p-Stat3 expression in the JAK2/Stat3 phosphorylation signaling pathway and regulation of bone marrow TPO/MPL metabolism.	icaritin	25-33	signal transducer and activator of transcription 3	Mus musculus	121-126
30224899-9	2018	Our results suggest that icaritin can significantly improve the health of mice with ITP via possible downregulation of p-Stat3 expression in the JAK2/Stat3 phosphorylation signaling pathway and regulation of bone marrow TPO/MPL metabolism.	icaritin	25-33	signal transducer and activator of transcription 3	Mus musculus	150-155
30181918-5	2018	In this study, we demonstrated that T cell-specific STAT3 deletion alleviated DSS-induced colitis in mice, resulting in reduced histological scores and myeloperoxidase (MPO) activity.	Dextran Sulfate	78-81	signal transducer and activator of transcription 3	Mus musculus	52-57
30181918-6	2018	Importantly, the population of T cells in the spleen and lymph nodes was significantly decreased in the control and DSS-induced groups of STAT3 KO mice.	Dextran Sulfate	116-119	signal transducer and activator of transcription 3	Mus musculus	138-143
29890157-0	2018	Ginkgolide K promotes angiogenesis in a middle cerebral artery occlusion mouse model via activating JAK2/STAT3 pathway.	ginkgolide K	0-12	signal transducer and activator of transcription 3	Mus musculus	105-110
30127274-8	2018	Moreover, Sp17high (PD-L1+MHCII-) cell populations showed significantly enhanced resistance to Paclitaxel-induced cell death in vitro compared to Sp17low (PD-L1-MHCII+) cells, which was associated in turn with increased STAT3 expression.	Paclitaxel	95-105	signal transducer and activator of transcription 3	Mus musculus	220-225
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	signal transducer and activator of transcription 3	Mus musculus	212-217
30061214-5	2018	RESULTS: The diet supplemented with quercetin induced CB1-R gene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation).	Quercetin	36-45	signal transducer and activator of transcription 3	Mus musculus	122-127
30061214-5	2018	RESULTS: The diet supplemented with quercetin induced CB1-R gene expression and protein, inhibiting the protein levels of STAT3 and p-STAT3 (both mediators of cell proliferation).	Quercetin	36-45	signal transducer and activator of transcription 3	Mus musculus	134-139
29753615-0	2018	Targeting the proinflammatory cytokines, oxidative stress, apoptosis and TGF-beta1/STAT-3 signaling by irbesartan to ameliorate doxorubicin-induced hepatotoxicity.	Irbesartan	103-113	signal transducer and activator of transcription 3	Mus musculus	83-89
29933193-4	2018	Independent of this, treatment with miRNA-200b obviously attenuated inflammatory responses, as indicated by down-regulating tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta) and blockade of AKT2-mediated NF-kappaB/IL-6/STAT3 signaling pathway.	mirna-200b	36-46	signal transducer and activator of transcription 3	Mus musculus	253-258
29753615-0	2018	Targeting the proinflammatory cytokines, oxidative stress, apoptosis and TGF-beta1/STAT-3 signaling by irbesartan to ameliorate doxorubicin-induced hepatotoxicity.	Doxorubicin	128-139	signal transducer and activator of transcription 3	Mus musculus	83-89
29945025-10	2018	Unlike BHB, Lac administration markedly induced the reparative STAT3 and ERK phosphorylation in the livers of Con A-intoxicated mice at the early time point.	Lactic Acid	12-15	signal transducer and activator of transcription 3	Mus musculus	63-68
29753615-8	2018	Irbesartan administration to DOX-treated mice induced significant decrease in serum ALT, AST, ALP, total bilirubin, tissue TGF-beta1, TNF-alpha, IL-6 and liver weight/body weight ratio associated with significant increase in food intake, serum albumin, tissue Nrf2/HO-1 content, STAT-3 and antioxidant enzymes and significant improvement in the histopathological picture compared to DOX group.	Irbesartan	0-10	signal transducer and activator of transcription 3	Mus musculus	279-285
29368095-5	2018	Mechanistic studies demonstrated that FAD attenuated the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.	falcarindiol	38-41	signal transducer and activator of transcription 3	Mus musculus	104-109
29753615-8	2018	Irbesartan administration to DOX-treated mice induced significant decrease in serum ALT, AST, ALP, total bilirubin, tissue TGF-beta1, TNF-alpha, IL-6 and liver weight/body weight ratio associated with significant increase in food intake, serum albumin, tissue Nrf2/HO-1 content, STAT-3 and antioxidant enzymes and significant improvement in the histopathological picture compared to DOX group.	Doxorubicin	29-32	signal transducer and activator of transcription 3	Mus musculus	279-285
29864483-0	2018	Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-kappaB signalling pathway modulation.	Linagliptin	26-37	signal transducer and activator of transcription 3	Mus musculus	153-158
29864483-11	2018	Interestingly, linagliptin diminished phosphorylated JAK2, phosphorylated STAT3 and NF-kappaB p65 protein expression while up-regulating phosphorylated AMP-activated protein kinase (p-AMPK) protein and SIRT1 gene expression levels.	Linagliptin	15-26	signal transducer and activator of transcription 3	Mus musculus	74-79
29864483-12	2018	In conclusion, linagliptin exerted a neuroprotective effect in mice with cuprizone-induced demyelination possibly by modulating AMPK/SIRT1 and JAK2/STAT3/NF-kappaB signalling pathways.	Linagliptin	15-26	signal transducer and activator of transcription 3	Mus musculus	148-153
29864483-12	2018	In conclusion, linagliptin exerted a neuroprotective effect in mice with cuprizone-induced demyelination possibly by modulating AMPK/SIRT1 and JAK2/STAT3/NF-kappaB signalling pathways.	Cuprizone	73-82	signal transducer and activator of transcription 3	Mus musculus	148-153
30083161-5	2018	After blocking the IL-6/STAT3 signaling pathway with the IL-6 receptor antibody or STAT3 antagonist JSI-124 in tumor-bearing mice, significant shrinkage of primary tumors and decrease in lung metastatic nodules were observed in vivo, accompanied by the dramatic decrease of e-MDSC recruitment and recovery of anti-tumor T cell immunity.	cucurbitacin I	100-107	signal transducer and activator of transcription 3	Mus musculus	24-29
30083161-5	2018	After blocking the IL-6/STAT3 signaling pathway with the IL-6 receptor antibody or STAT3 antagonist JSI-124 in tumor-bearing mice, significant shrinkage of primary tumors and decrease in lung metastatic nodules were observed in vivo, accompanied by the dramatic decrease of e-MDSC recruitment and recovery of anti-tumor T cell immunity.	cucurbitacin I	100-107	signal transducer and activator of transcription 3	Mus musculus	83-88
30097127-0	2018	Investigation of ovatodiolide, a macrocyclic diterpenoid, as a potential inhibitor of oral cancer stem-like cells properties via the inhibition of the JAK2/STAT3/JARID1B signal circuit.	ovatodiolide	17-29	signal transducer and activator of transcription 3	Mus musculus	156-161
29794014-7	2018	Mechanistically, PRMT1-dependent modification of asymmetric histone 4 arginine 3 dimethylation is required to stabilize the stimulatory STAT3 to displace the inhibitory STAT5 at IL-17 locus, resulting in the activation of IL-17 gene.	Arginine	70-78	signal transducer and activator of transcription 3	Mus musculus	136-141
30097127-9	2018	Furthermore, Ova-mediated anti-cancer effects were associated with the dose-dependent reduction in the expression levels of STAT3, p-STAT3, pJAK2, pAKT and pERK1/2 protein.	ovatodiolide	13-16	signal transducer and activator of transcription 3	Mus musculus	124-129
30097127-9	2018	Furthermore, Ova-mediated anti-cancer effects were associated with the dose-dependent reduction in the expression levels of STAT3, p-STAT3, pJAK2, pAKT and pERK1/2 protein.	ovatodiolide	13-16	signal transducer and activator of transcription 3	Mus musculus	133-138
30097127-12	2018	CONCLUSION: These results demonstrate that Ova effectively suppressed oral tumorigenesis and stemness properties via JAK2/STAT3 signaling.	ovatodiolide	43-46	signal transducer and activator of transcription 3	Mus musculus	122-127
29425687-5	2018	Mutation of lysine-679 on the sumoylation site of the STAT3 effectively blocked the ASC-J9 -suppressed PCa cell invasion in both in vitro cell lines and in vivo mouse models.	Lysine	12-18	signal transducer and activator of transcription 3	Mus musculus	54-59
29898959-4	2018	Targeted disruption of STAT3 signaling in myeloid cells significantly accelerated development of pathological skin fibrosis in a model of chronic bleomycin-induced tissue injury, whereas the impact on wound closure dynamics and quality of healing after acute excision skin injury was minor.	Bleomycin	146-155	signal transducer and activator of transcription 3	Mus musculus	23-28
29650774-6	2018	Furthermore, rare variants in STAT3 associated with worse metformin response (q &lt;0.1).	Metformin	58-67	signal transducer and activator of transcription 3	Mus musculus	30-35
29650774-8	2018	Here, we provide novel evidence for associations of common and rare variants in PRPF31, CPA6, and STAT3 with metformin response that may provide insight into mechanisms important for metformin efficacy in T2D.	Metformin	109-118	signal transducer and activator of transcription 3	Mus musculus	98-103
29650774-8	2018	Here, we provide novel evidence for associations of common and rare variants in PRPF31, CPA6, and STAT3 with metformin response that may provide insight into mechanisms important for metformin efficacy in T2D.	Metformin	183-192	signal transducer and activator of transcription 3	Mus musculus	98-103
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Epinephrine	79-89	signal transducer and activator of transcription 3	Mus musculus	117-122
29797458-1	2018	STAT3 phosphorylation at tyrosine 705 (STAT3pY705 ), triggered by the addition of the leukemia inhibitory factor (LIF), can maintain mouse embryonic stem cell (mESC) self-renewal and reprogram mouse epiblast stem cells (EpiSCs) to enter a naive pluripotent state.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	0-5
29976114-6	2018	Last, exogenous activation of the AhR/IL-22/Stat3 signaling pathway with the AhR agonist 6-formylindolo(3,2-b)carbazole (Ficz) rescued antimicrobial molecule levels markedly after antibiotic treatment to levels similar to those following reconstitution of intestinal microbiota by FMT.	6-formylindolo(3,2-b)carbazole	89-119	signal transducer and activator of transcription 3	Mus musculus	44-49
30197360-7	2018	Then, the STAT3 silencing was evaluated by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) using oligofectamine containing STAT3 short interfering RNA (siRNA).	oligofectamine	124-138	signal transducer and activator of transcription 3	Mus musculus	10-15
30197360-8	2018	Oligofectamine containing STAT3 siRNA and control siRNA were added at a final concentration of 100 nM siRNA.	oligofectamine	0-14	signal transducer and activator of transcription 3	Mus musculus	26-31
30197360-11	2018	Incubation of J774A.1 cells with oligofectamine containing STAT3 siRNA knockdown the STAT3 expression significantly both in 48 and 72 h study; however, the effect was more pronounced in 72 h study.	oligofectamine	33-47	signal transducer and activator of transcription 3	Mus musculus	59-64
30197360-11	2018	Incubation of J774A.1 cells with oligofectamine containing STAT3 siRNA knockdown the STAT3 expression significantly both in 48 and 72 h study; however, the effect was more pronounced in 72 h study.	oligofectamine	33-47	signal transducer and activator of transcription 3	Mus musculus	85-90
30197360-13	2018	Moreover, silencing of STAT3 by siRNA delivery using oligofectamine delivery suggests that siRNA delivery using vehicles like nanoliposome could be a useful therapeutic agent in M2 macrophage therapy and its switch to M1 macrophages.	oligofectamine	53-67	signal transducer and activator of transcription 3	Mus musculus	23-28
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Norepinephrine	94-108	signal transducer and activator of transcription 3	Mus musculus	117-122
29845215-0	2018	Pien Tze Huang ameliorates DSS-induced colonic inflammation in a mouse colitis model through inhibition of the IL-6/STAT3 pathway.	Dextran Sulfate	27-30	signal transducer and activator of transcription 3	Mus musculus	116-121
29845215-10	2018	Finally, the increased phosphorylation level of STAT3, induced either by DSS in experimental mice or by IL-6 in the differentiated human colorectal carcinoma cells, was significantly suppressed by PZH.	Dextran Sulfate	73-76	signal transducer and activator of transcription 3	Mus musculus	48-53
29959375-0	2018	1-Methyl-D-tryptophan Reduces Tumor CD133+ cells, Wnt/beta-catenin and NF-kappabetap65 while Enhances Lymphocytes NF-kappabeta2, STAT3, and STAT4 Pathways in Murine Pancreatic Adenocarcinoma.	1-methyltryptophan	0-21	signal transducer and activator of transcription 3	Mus musculus	129-134
29694939-0	2018	Peracetylated hydroxytyrosol, a new hydroxytyrosol derivate, attenuates LPS-induced inflammatory response in murine peritoneal macrophages via regulation of non-canonical inflammasome, Nrf2/HO1 and JAK/STAT signaling pathways.	3,4-dihydroxyphenylethanol	14-28	signal transducer and activator of transcription 3	Mus musculus	202-206
29869055-19	2018	Inhibiting the STAT3 phosphorylation/activation by the STAT3 inhibitor, BP-1-102 (3 mg/kg/day, o.g.	BP-1-102	72-80	signal transducer and activator of transcription 3	Mus musculus	15-20
29869055-19	2018	Inhibiting the STAT3 phosphorylation/activation by the STAT3 inhibitor, BP-1-102 (3 mg/kg/day, o.g.	BP-1-102	72-80	signal transducer and activator of transcription 3	Mus musculus	55-60
29963272-12	2018	Expression of STAT3 and downstream regulated molecules, NANOG and SOX2, was reduced in 4T1 cells after DE-EDCP treatment.	edcp	106-110	signal transducer and activator of transcription 3	Mus musculus	14-19
29654783-0	2018	Resveratrol attenuates pro-inflammatory cytokines and activation of JAK1-STAT3 in BTBR T+ Itpr3tf/J autistic mice.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	73-78
29654783-8	2018	Resveratrol (20 and 40 mg/kg)-treated mice had significantly decreased in IL-6+, TNF-alpha+, IFN-gamma+, and STAT3+ in CD4+ spleen cells as compared with BTBR control mice.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	109-114
29654783-9	2018	Resveratrol treatment also decreased IL-6, TNF-alpha, IFN-gamma, JAK1, and STAT3 mRNA expression levels as compared with BTBR control mice in the brain tissue.	Resveratrol	0-11	signal transducer and activator of transcription 3	Mus musculus	75-80
29654783-11	2018	Taken together, these results indicate the efficacy of resveratrol in reducing cytokines and JAK-1/STAT3 signaling in BTBR mice, which is a novel and important finding and might be important for future therapies in neuroimmune dysfunction.	Resveratrol	55-66	signal transducer and activator of transcription 3	Mus musculus	99-104
29510292-0	2018	Thymoquinone Induces Apoptosis in B16-F10 Melanoma Cell Through Inhibition of p-STAT3 and Inhibits Tumor Growth in a Murine Intracerebral Melanoma Model.	thymoquinone	0-12	signal transducer and activator of transcription 3	Mus musculus	80-85
30083262-10	2018	Data from murine models exhibited a marked reduction in the tumor size, increased apoptosis, inhibited NF-kappaB, S1PR1/STAT3, Shh signaling and desmoplasia, modulated the expression of gemcitabine-metabolizing transport enzymes, and restored the expression of tumor suppressor gene PP2A.	gemcitabine	186-197	signal transducer and activator of transcription 3	Mus musculus	120-125
29673861-0	2018	IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings.	Cocaine	38-45	signal transducer and activator of transcription 3	Mus musculus	103-108
29477240-3	2018	SIRT1 encodes an NAD-dependent deacetylase that modifies the activity of key transcriptional regulators affected in diabetic kidneys, including NF-kappaB, STAT3, p53, FOXO4, and PGC1-alpha.	NAD	17-20	signal transducer and activator of transcription 3	Mus musculus	155-160
29510292-12	2018	TQ inhibited p-STAT3, resulting in apoptosis through regulation of proapoptotic and antiapoptotic proteins.	thymoquinone	0-2	signal transducer and activator of transcription 3	Mus musculus	15-20
29867489-12	2018	Meanwhile, EAEO suppressed the phosphorylation of STAT3 and AKT, indicative of its anti-HCC potential.	eaeo	11-15	signal transducer and activator of transcription 3	Mus musculus	50-55
29784961-0	2018	Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway.	Polysaccharides	20-35	signal transducer and activator of transcription 3	Mus musculus	135-140
29784961-0	2018	Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway.	Cyclophosphamide	79-95	signal transducer and activator of transcription 3	Mus musculus	135-140
29678906-7	2018	Consistent with a pivotal role for this pathway in driving persistent fibrosis, a STAT3 inhibitor attenuated murine pulmonary fibrosis when administered in a therapeutic fashion after bleomycin injury.	Bleomycin	184-193	signal transducer and activator of transcription 3	Mus musculus	82-87
29794990-10	2018	These results demonstrated that antrodan provides a novel, complementary therapeutic strategy against cancer metastasis, by attenuating the activities of MMP-2 and -9 through the modulation of STAT3/MAPK/ERK/JNK signaling pathways, and of the host"s immune system.	antrodan	32-40	signal transducer and activator of transcription 3	Mus musculus	193-198
29867482-0	2018	Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3.	linderane	0-9	signal transducer and activator of transcription 3	Mus musculus	130-135
29867489-13	2018	In summary, we determined that EAEO treatment promoted HCC apoptosis via activation of the apoptotic signaling pathway in mitochondria and endoplasmic reticulum, as well as repressed the activity of STAT3 and AKT in HCC cells.	eaeo	31-35	signal transducer and activator of transcription 3	Mus musculus	199-204
29867482-10	2018	Linderane indirectly activated PDE3 through extracellular regulated protein kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) activation.	linderane	0-9	signal transducer and activator of transcription 3	Mus musculus	100-150
29669962-0	2018	Renal protective effect of Paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice.	peoniflorin	27-39	signal transducer and activator of transcription 3	Mus musculus	62-67
29867482-10	2018	Linderane indirectly activated PDE3 through extracellular regulated protein kinase 1/2 (ERK1/2) and signal transducer and activator of transcription 3 (STAT3) activation.	linderane	0-9	signal transducer and activator of transcription 3	Mus musculus	152-157
29669962-6	2018	These data reveal that Paeoniflorin attenuates renal lesions in diabetic mice and these protective effects may be associated with the prevention of macrophage infiltration and inhibition of the JAK2/STAT3 signaling pathway.	peoniflorin	23-35	signal transducer and activator of transcription 3	Mus musculus	199-204
29656647-0	2018	Tea Polysaccharides Inhibit Colitis-Associated Colorectal Cancer via Interleukin-6/STAT3 Pathway.	tea polysaccharides	0-19	signal transducer and activator of transcription 3	Mus musculus	83-88
29724065-11	2018	We conclude that TRYP improves the health condition of mice with DSS induced colitis by regulating the TNF-alpha/NF-kappaBp65 and IL-6/STAT3 signaling pathways via inhibiting the degradation of IkappaBalpha and the phosphorylation of STAT3.	Dextran Sulfate	65-68	signal transducer and activator of transcription 3	Mus musculus	135-140
29724065-0	2018	Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-alpha/NF-kappaB and IL-6/STAT3 Pathways.	tryptanthrine	0-12	signal transducer and activator of transcription 3	Mus musculus	125-130
29554498-8	2018	In addition, MSCs cultured in 5 mM Mg2+ expressed lower levels of pNFkappaB/NFkappaB and higher levels of pSTAT-3/STAT-3.	magnesium ion	35-39	signal transducer and activator of transcription 3	Mus musculus	107-113
29477834-6	2018	Calpain 1-specific inhibitor PD151746 further increased p-STAT3 expression and augmented the promoting effects of EE on post-stroke SVZ neural precursor cells (NPCs) proliferation and functional recovery.	PD 151746	29-37	signal transducer and activator of transcription 3	Mus musculus	58-63
29360439-0	2018	Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation.	artenimol	0-18	signal transducer and activator of transcription 3	Mus musculus	30-35
29731242-8	2018	In high-fat diet-induced obese mice, the oral administration of KY-226 (30 and 60 mg/kg/day, 4 weeks) decreased body weight gain, food consumption, and fat volume gain with increases in phosphorylated STAT3 in the hypothalamus.	KY-226	64-70	signal transducer and activator of transcription 3	Mus musculus	201-206
29411774-7	2018	Mechanistically, SCFA activated mTOR and STAT3 in IEC, and knockdown of mTOR and STAT3 impaired SCFA induction of AMP production.	Adenosine Monophosphate	114-117	signal transducer and activator of transcription 3	Mus musculus	81-86
29360439-8	2018	Moreover, DHA effectively suppressed STAT3 phosphorylation, and STAT3 inactivation resulted in the downregulation of Mcl-1 and Survivin, functioning to enhance ABT-263-induced cytotoxicity.	artenimol	10-13	signal transducer and activator of transcription 3	Mus musculus	37-42
29360439-10	2018	Together, DHA effectively inhibits STAT3 activity and modulates expression of Mcl-1, Survivin and Bim, thereby synergizing with ABT-263 to trigger apoptosis in NSCLC cells harboring EGFR or RAS mutation.	artenimol	10-13	signal transducer and activator of transcription 3	Mus musculus	35-40
29339053-5	2018	Furthermore, the expressions of p-STAT3 were colocalized with NLRP3-positive cells in DRG neurons, and inhibition of STAT3 by intrathecal injection of AAV-Cre-GFP into STAT3flox/flox mice or inhibitor S3I-201 suppressed the upregulation of NLRP3 and mechanical allodynia induced by bortezomib treatment.	NSC 74859	201-208	signal transducer and activator of transcription 3	Mus musculus	117-122
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	36-48	signal transducer and activator of transcription 3	Mus musculus	129-134
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	50-52	signal transducer and activator of transcription 3	Mus musculus	129-134
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	signal transducer and activator of transcription 3	Mus musculus	128-133
29339053-5	2018	Furthermore, the expressions of p-STAT3 were colocalized with NLRP3-positive cells in DRG neurons, and inhibition of STAT3 by intrathecal injection of AAV-Cre-GFP into STAT3flox/flox mice or inhibitor S3I-201 suppressed the upregulation of NLRP3 and mechanical allodynia induced by bortezomib treatment.	NSC 74859	201-208	signal transducer and activator of transcription 3	Mus musculus	117-122
29339053-5	2018	Furthermore, the expressions of p-STAT3 were colocalized with NLRP3-positive cells in DRG neurons, and inhibition of STAT3 by intrathecal injection of AAV-Cre-GFP into STAT3flox/flox mice or inhibitor S3I-201 suppressed the upregulation of NLRP3 and mechanical allodynia induced by bortezomib treatment.	Bortezomib	282-292	signal transducer and activator of transcription 3	Mus musculus	117-122
28926115-9	2018	Besides these, STAT3 was predicted as a binding target of miR-125b in OSCC.	mir-125b	58-66	signal transducer and activator of transcription 3	Mus musculus	15-20
29339053-5	2018	Furthermore, the expressions of p-STAT3 were colocalized with NLRP3-positive cells in DRG neurons, and inhibition of STAT3 by intrathecal injection of AAV-Cre-GFP into STAT3flox/flox mice or inhibitor S3I-201 suppressed the upregulation of NLRP3 and mechanical allodynia induced by bortezomib treatment.	Bortezomib	282-292	signal transducer and activator of transcription 3	Mus musculus	117-122
29250925-0	2018	Cucurbitacin-B attenuates CCl4 -induced hepatic fibrosis in mice through inhibition of STAT-3.	cucurbitacin B	0-14	signal transducer and activator of transcription 3	Mus musculus	87-93
29134640-0	2018	Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.	Inositol	154-166	signal transducer and activator of transcription 3	Mus musculus	49-54
28926115-10	2018	Overexpression of MALAT1 was able to suppress the tumor inhibitory effect of miR-125b mimics via upregulating STAT3.	mir-125b	77-85	signal transducer and activator of transcription 3	Mus musculus	110-115
28926115-13	2018	In conclusion, MALAT1 can function as a competing endogenous RNA (ceRNA) to modulate STAT3 expression by absorbing miR-125b in OSCC and could be used as a novel therapeutic target in OSCC diagnosis and treatment.	mir-125b	115-123	signal transducer and activator of transcription 3	Mus musculus	85-90
29562463-12	2018	On the contrary, RAPA-treated group exhibited CD4+ CD25+ Tregs with a reduction in apoptosis rate [(22.39+-3.71)%], Akt phosphorylation and Stat3 phosphorylation compared with the SAA group (P&lt;0.05, respectively).	Sirolimus	17-21	signal transducer and activator of transcription 3	Mus musculus	140-145
29441719-6	2018	On mechanistic levels, AZD1208 reduced not only the expressions of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and perilipin A but also the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells.	AZD1208	23-30	signal transducer and activator of transcription 3	Mus musculus	286-336
29441719-6	2018	On mechanistic levels, AZD1208 reduced not only the expressions of CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and perilipin A but also the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) in differentiating 3T3-L1 cells.	AZD1208	23-30	signal transducer and activator of transcription 3	Mus musculus	338-344
29562202-7	2018	Thus, our computational and experimental approach identified Fas as a regulator of the Th17-to-Th1 cell balance by controlling the availability of opposing STAT1 and STAT3 to have a direct impact on autoimmunity.	ammonium ferrous sulfate	61-64	signal transducer and activator of transcription 3	Mus musculus	166-171
29529473-8	2018	BAY 11-7082 eliminates NF-kappaB activation in regenerating basal cells of acidic bile-treated HM and prevents overexpression of molecules central to head and neck cancer, including bcl-2, STAT3, EGFR, TNF-alpha, and WNT5A.	3-(4-methylphenylsulfonyl)-2-propenenitrile	0-11	signal transducer and activator of transcription 3	Mus musculus	189-194
29682172-2	2018	This study investigated whether inhibition of the Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway by momelotinib is sufficient in suppressing tumor burden and prolonging the disease-free survival period in a mouse model of ovarian cancer.	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	142-153	signal transducer and activator of transcription 3	Mus musculus	124-129
29682172-3	2018	We demonstrate that paclitaxel treatment enhanced JAK2/STAT3 activation which resulted in the enrichment of cancer stem cell (CSC)-like phenotype in the surviving ovarian cancer cells in vitro and in in vivo mouse xenografts.	Paclitaxel	20-30	signal transducer and activator of transcription 3	Mus musculus	55-60
29682172-4	2018	Combined treatment with paclitaxel and momelotinib inhibited paclitaxel-induced JAK2/STAT3 activation and CSC-like development in mice xenografts, and consequently reduced the tumor burden significantly greater than that achieved by paclitaxel-treatment alone.	Paclitaxel	24-34	signal transducer and activator of transcription 3	Mus musculus	85-90
29682172-4	2018	Combined treatment with paclitaxel and momelotinib inhibited paclitaxel-induced JAK2/STAT3 activation and CSC-like development in mice xenografts, and consequently reduced the tumor burden significantly greater than that achieved by paclitaxel-treatment alone.	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	39-50	signal transducer and activator of transcription 3	Mus musculus	85-90
29682172-4	2018	Combined treatment with paclitaxel and momelotinib inhibited paclitaxel-induced JAK2/STAT3 activation and CSC-like development in mice xenografts, and consequently reduced the tumor burden significantly greater than that achieved by paclitaxel-treatment alone.	Paclitaxel	61-71	signal transducer and activator of transcription 3	Mus musculus	85-90
29682172-4	2018	Combined treatment with paclitaxel and momelotinib inhibited paclitaxel-induced JAK2/STAT3 activation and CSC-like development in mice xenografts, and consequently reduced the tumor burden significantly greater than that achieved by paclitaxel-treatment alone.	Paclitaxel	61-71	signal transducer and activator of transcription 3	Mus musculus	85-90
29326072-6	2018	Furthermore, BSNQ and OSNQ suppressed tumor growth and modulated MAPK and STAT3 signaling in mouse xenografts without detectable effects on body weight or hematological parameters.	bsnq	13-17	signal transducer and activator of transcription 3	Mus musculus	74-79
29433938-2	2018	Here, we describe a dual-function molecule consisting of a clinically relevant TLR9 agonist (CpG7909) and a STAT3 inhibitor in the form of a high-affinity decoy oligodeoxynucleotide (dODN).	Oligodeoxyribonucleotides	161-181	signal transducer and activator of transcription 3	Mus musculus	108-113
29433938-2	2018	Here, we describe a dual-function molecule consisting of a clinically relevant TLR9 agonist (CpG7909) and a STAT3 inhibitor in the form of a high-affinity decoy oligodeoxynucleotide (dODN).	dodn	183-187	signal transducer and activator of transcription 3	Mus musculus	108-113
29552018-0	2018	Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2-Signal Transducer and Activator of Transcription 3 Pathway.	Deoxyglucose	28-42	signal transducer and activator of transcription 3	Mus musculus	122-172
29552018-8	2018	In addition, treatment with 2-DG or ML265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	Deoxyglucose	28-32	signal transducer and activator of transcription 3	Mus musculus	84-134
29552018-8	2018	In addition, treatment with 2-DG or ML265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	Deoxyglucose	28-32	signal transducer and activator of transcription 3	Mus musculus	136-141
29552018-8	2018	In addition, treatment with 2-DG or ML265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	TEPP-46	36-41	signal transducer and activator of transcription 3	Mus musculus	84-134
29552018-8	2018	In addition, treatment with 2-DG or ML265 suppressed the phosphorylation of nuclear signal transducer and activator of transcription 3 (STAT3).	TEPP-46	36-41	signal transducer and activator of transcription 3	Mus musculus	136-141
29427792-5	2018	The analysis of the molecular mechanism of STATs signaling reveals that H2O2 induces S-glutathionylation of both STAT1 and STAT3.	Hydrogen Peroxide	72-76	signal transducer and activator of transcription 3	Mus musculus	123-128
29326072-6	2018	Furthermore, BSNQ and OSNQ suppressed tumor growth and modulated MAPK and STAT3 signaling in mouse xenografts without detectable effects on body weight or hematological parameters.	osnq	22-26	signal transducer and activator of transcription 3	Mus musculus	74-79
29328945-3	2018	The present study is to investigate the mechanism underlying the effect of astaxanthin on autophagy and apoptosis via the JAK/STAT3 pathway.	astaxanthine	75-86	signal transducer and activator of transcription 3	Mus musculus	126-131
29328945-8	2018	RESULTS: Astaxanthin administration markedly reduced serum digestive enzyme activities, pancreatic histological scores, proinflammatory cytokine levels (tumor necrosis factor-alpha (TNF-alpha), Interleukin-1beta (IL-1beta), and Interleukin-6 (IL-6)), MPO and JAK/STAT3 activity.	astaxanthine	9-20	signal transducer and activator of transcription 3	Mus musculus	263-268
29414653-3	2018	Eight genes Ltf, Tnf, Il6, Jun, Il12b, Stat3, Rel and Crem could regulate the inflammatory factors, and TNF signaling pathway and Jak-STAT signaling pathway might play an important role in the mechanism through which DECB protected the liver of mice.	decb	217-221	signal transducer and activator of transcription 3	Mus musculus	39-44
29414653-3	2018	Eight genes Ltf, Tnf, Il6, Jun, Il12b, Stat3, Rel and Crem could regulate the inflammatory factors, and TNF signaling pathway and Jak-STAT signaling pathway might play an important role in the mechanism through which DECB protected the liver of mice.	decb	217-221	signal transducer and activator of transcription 3	Mus musculus	134-138
29191973-7	2018	Finally, inhibition of the IL6/STAT3 pathway by tocilizumab combined with HMGB1 knockdown inhibited enzalutamide-induced resistance in an orthotopic prostate cancer mouse model.Conclusions: Enzalutamide elevates HMGB1 levels, which recruits and activates TAMs.	enzalutamide	100-112	signal transducer and activator of transcription 3	Mus musculus	31-36
29773105-0	2018	[Protective role of green tea polyphenols in intestinal mucosal barrier function of mice with colitis induced by TNBS through inhibiting JAK2/STAT3 pathway].	Polyphenols	30-41	signal transducer and activator of transcription 3	Mus musculus	142-147
29773105-0	2018	[Protective role of green tea polyphenols in intestinal mucosal barrier function of mice with colitis induced by TNBS through inhibiting JAK2/STAT3 pathway].	Trinitrobenzenesulfonic Acid	113-117	signal transducer and activator of transcription 3	Mus musculus	142-147
29773105-12	2018	Western blot analysis showed that GTP down-regulated the JAK2/STAT3 signaling pathway in the intestinal mucosa.	Guanosine Triphosphate	34-37	signal transducer and activator of transcription 3	Mus musculus	62-67
29773105-13	2018	Conclusion GTP has a significant therapeutic effect on TNBS-induced colitis through down-regulating the JAK2/STAT3 signaling pathway.	Guanosine Triphosphate	11-14	signal transducer and activator of transcription 3	Mus musculus	109-114
29773105-13	2018	Conclusion GTP has a significant therapeutic effect on TNBS-induced colitis through down-regulating the JAK2/STAT3 signaling pathway.	Trinitrobenzenesulfonic Acid	55-59	signal transducer and activator of transcription 3	Mus musculus	109-114
29396431-7	2018	PCa cells exposed to m-Tyr in vitro showed reduced cell viability, downregulated NFkappaB/STAT3/Notch axis, and induced autophagy; effects reversed by Phe.	3-tyrosine	21-26	signal transducer and activator of transcription 3	Mus musculus	90-95
29396431-7	2018	PCa cells exposed to m-Tyr in vitro showed reduced cell viability, downregulated NFkappaB/STAT3/Notch axis, and induced autophagy; effects reversed by Phe.	Phenylalanine	151-154	signal transducer and activator of transcription 3	Mus musculus	90-95
29328945-9	2018	CONCLUSION: Collectively, these results indicate that astaxanthin inhibits pancreatic injury in AP by targeting JAK/STAT3-mediated apoptosis and autophagy.	astaxanthine	54-65	signal transducer and activator of transcription 3	Mus musculus	116-121
29629345-6	2018	Results: Administration of curcumin significantly attenuated the severity of DSS-induced colitis and the activation of NF-kappaB and STAT3 as well as expression of COX-2 and inducible nitric oxide synthase.	Curcumin	27-35	signal transducer and activator of transcription 3	Mus musculus	133-138
29629345-8	2018	Conclusions: Intragastric administration of curcumin inhibited the experimentally induced murine colitis, which was associated with inhibition of pro-inflammatory signaling mediated by NF-kappaB and STAT3.	Curcumin	44-52	signal transducer and activator of transcription 3	Mus musculus	199-204
29199006-11	2018	Also, LB-100 decreased activation of STAT3 and expression of its downstream proteins.	lb100	6-12	signal transducer and activator of transcription 3	Mus musculus	37-42
29445144-7	2018	Mechanistically, lenalidomide significantly increased expression and autocrine secretion of IL10, subsequently activated STAT3-mediated expression of Ym1.	Lenalidomide	17-29	signal transducer and activator of transcription 3	Mus musculus	121-126
29279307-8	2018	Similar studies performed on P2X7 or P2Y2 receptor knock-out mice indicate P2Y2 receptors are involved in the activation of STAT3 after ATP injection or conditioning lesion, whereas P2X7 receptors are not.	Adenosine Triphosphate	136-139	signal transducer and activator of transcription 3	Mus musculus	124-129
29243082-0	2018	Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy.	taxifolin	0-16	signal transducer and activator of transcription 3	Mus musculus	92-97
29243082-0	2018	Dihydroquercetin ameliorated acetaminophen-induced hepatic cytotoxicity via activating JAK2/STAT3 pathway and autophagy.	Acetaminophen	29-42	signal transducer and activator of transcription 3	Mus musculus	92-97
29243082-7	2018	Further study revealed that DHQ induced phosphorylation of Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) cascade and thus modulated expression of anti-apoptotic Bcl-2 family proteins.	taxifolin	28-31	signal transducer and activator of transcription 3	Mus musculus	131-136
29243082-10	2018	These studies demonstrated, for the first time, that DHQ possessed hepatocellular protective effects in the context of APAP-induced cytotoxicity and subsequently revealed that the mechanisms comprised activation of JAK2/STAT3 signaling pathway and autophagy.	taxifolin	53-56	signal transducer and activator of transcription 3	Mus musculus	220-225
29191973-7	2018	Finally, inhibition of the IL6/STAT3 pathway by tocilizumab combined with HMGB1 knockdown inhibited enzalutamide-induced resistance in an orthotopic prostate cancer mouse model.Conclusions: Enzalutamide elevates HMGB1 levels, which recruits and activates TAMs.	enzalutamide	190-202	signal transducer and activator of transcription 3	Mus musculus	31-36
29379096-8	2018	Wild type obese mice treated with FLX showed reduced weight gain, increased energy output, and differently from untreated obese mice, a preserved acute response to leptin in terms of activation of the intracellular leptin transducer STAT3.	Fluoxetine	34-37	signal transducer and activator of transcription 3	Mus musculus	233-238
28771862-0	2018	Induction of transient cell cycle arrest by H2 O2 via modulation of ultradian oscillations of Hes1, Socs3, and p-Stat3 in fibroblast cells.	Hydrogen Peroxide	44-49	signal transducer and activator of transcription 3	Mus musculus	113-118
28771862-5	2018	H2 O2 generated a delay in p-Stat3 and Socs3 mRNAs followed by suppression of Hes1 protein.	Hydrogen Peroxide	0-5	signal transducer and activator of transcription 3	Mus musculus	29-34
28880787-5	2018	Next, animals were allocated to hepatic RFA or sham treatment with or without STAT3 (signal transducer and activator of transcription 3) inhibitor S3I-201 for periablational phosphorylated STAT3 immunohistochemistry analysis at 24 hours.	NSC 74859	147-154	signal transducer and activator of transcription 3	Mus musculus	78-83
28880787-12	2018	STAT3 inhibition with micellar curcumin also suppressed postablation stimulation of distant tumor growth, proliferation, and microvascular density (P &lt; .01).	Curcumin	31-39	signal transducer and activator of transcription 3	Mus musculus	0-5
29849942-6	2018	We show that ruxolitinib inhibits STAT3 activation and ovarian tumor growth both in ovarian cancer cells and in an ovarian cancer mouse model.	ruxolitinib	13-24	signal transducer and activator of transcription 3	Mus musculus	34-39
29295936-7	2018	In addition, STAT3 negatively regulates the lethal type I IFN signaling pathway by inhibiting expression of IRF7, IRF9, STAT1, and STAT2 Inhibition of STAT3 activity by ruxolitinib synergizes with the type I IFN inducer lenalidomide in growth inhibition of ABC DLBCL cells in vitro and in a xenograft mouse model.	ruxolitinib	169-180	signal transducer and activator of transcription 3	Mus musculus	13-18
29295936-7	2018	In addition, STAT3 negatively regulates the lethal type I IFN signaling pathway by inhibiting expression of IRF7, IRF9, STAT1, and STAT2 Inhibition of STAT3 activity by ruxolitinib synergizes with the type I IFN inducer lenalidomide in growth inhibition of ABC DLBCL cells in vitro and in a xenograft mouse model.	ruxolitinib	169-180	signal transducer and activator of transcription 3	Mus musculus	151-156
29295936-7	2018	In addition, STAT3 negatively regulates the lethal type I IFN signaling pathway by inhibiting expression of IRF7, IRF9, STAT1, and STAT2 Inhibition of STAT3 activity by ruxolitinib synergizes with the type I IFN inducer lenalidomide in growth inhibition of ABC DLBCL cells in vitro and in a xenograft mouse model.	Lenalidomide	220-232	signal transducer and activator of transcription 3	Mus musculus	13-18
29295936-7	2018	In addition, STAT3 negatively regulates the lethal type I IFN signaling pathway by inhibiting expression of IRF7, IRF9, STAT1, and STAT2 Inhibition of STAT3 activity by ruxolitinib synergizes with the type I IFN inducer lenalidomide in growth inhibition of ABC DLBCL cells in vitro and in a xenograft mouse model.	Lenalidomide	220-232	signal transducer and activator of transcription 3	Mus musculus	151-156
30504685-12	2018	These results indicate that SHP2 nitration in macrophages might be involved in activation of the CD14-TLR4-NF-kappaB axis through STAT3 signaling in mice with DSS-induced colitis.	Dextran Sulfate	159-162	signal transducer and activator of transcription 3	Mus musculus	130-135
29329563-7	2018	O-PMs also induced the phosphorylation of AKT, p65, and STAT3.	o-pms	0-5	signal transducer and activator of transcription 3	Mus musculus	56-61
28639178-2	2018	Curcumin was encapsulated in DOTAP-based cationic liposomes and then complexed with STAT3 siRNA.	Curcumin	0-8	signal transducer and activator of transcription 3	Mus musculus	84-89
28639178-4	2018	The cell viability studies in B16F10 mouse melanoma cells have shown that the co-delivery of curcumin and STAT3 siRNA significantly (p &lt; 0.05) inhibited the cancer cell growth compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	93-101	signal transducer and activator of transcription 3	Mus musculus	222-227
28639178-7	2018	Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p &lt; 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	25-33	signal transducer and activator of transcription 3	Mus musculus	214-219
28639178-7	2018	Co-administration of the curcumin and STAT3 siRNA using liposomes significantly (p &lt; 0.05) inhibited the tumor progression as measured by tumor volume and tumor weight compared with either liposomal curcumin or STAT3 siRNA alone.	Curcumin	202-210	signal transducer and activator of transcription 3	Mus musculus	38-43
28639178-8	2018	Furthermore, the iontophoretic administration of curcumin-loaded liposome-siRNA complex showed similar effectiveness in inhibiting tumor progression and STAT3 protein suppression compared with intratumoral administration.	Curcumin	49-57	signal transducer and activator of transcription 3	Mus musculus	153-158
29040439-5	2018	Although EPA did not appear to affect obesity-linked inflammation, it suppressed the activation of the pro-tumorigenic IL-6 effector STAT3, contributing to the inhibition of tumor growth.	Eicosapentaenoic Acid	9-12	signal transducer and activator of transcription 3	Mus musculus	133-138
30355952-0	2018	2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma.	2-o-methylmagnolol	0-18	signal transducer and activator of transcription 3	Mus musculus	55-60
29961065-0	2018	Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation.	acteoside	0-12	signal transducer and activator of transcription 3	Mus musculus	181-186
28875329-0	2018	The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer.	Pyrimethamine	20-33	signal transducer and activator of transcription 3	Mus musculus	4-9
28875329-7	2018	Tumor-bearing mice treated with PYR showed reduced STAT3 activation in tumor cells, attenuated tumor growth, and reduced tumor-associated inflammation.	Pyrimethamine	32-35	signal transducer and activator of transcription 3	Mus musculus	51-56
29763909-7	2018	RESULTS: After DOCA-salt treatment, the expression of SOCS3, activation of gp130/JAK/STAT3, cardiac dysfunction and fibrosis in DOCA-salt mice were significantly elevated, which were markedly attenuated by eplerenone, a specific mineralocorticoid receptor (MR) blocker.	doca-salt	15-24	signal transducer and activator of transcription 3	Mus musculus	85-90
30439699-13	2018	Furthermore, we identified STAT3 as a direct target of miR-124, and downregulation of miR-124 ameliorated the diminished levels of STAT3 and p-STAT3 (Tyr705) in response to H2O2 or MI.	Hydrogen Peroxide	173-177	signal transducer and activator of transcription 3	Mus musculus	27-32
30439699-13	2018	Furthermore, we identified STAT3 as a direct target of miR-124, and downregulation of miR-124 ameliorated the diminished levels of STAT3 and p-STAT3 (Tyr705) in response to H2O2 or MI.	Hydrogen Peroxide	173-177	signal transducer and activator of transcription 3	Mus musculus	131-136
30439699-13	2018	Furthermore, we identified STAT3 as a direct target of miR-124, and downregulation of miR-124 ameliorated the diminished levels of STAT3 and p-STAT3 (Tyr705) in response to H2O2 or MI.	Hydrogen Peroxide	173-177	signal transducer and activator of transcription 3	Mus musculus	131-136
30439699-14	2018	STAT3 inhibitor, stattic, was shown to attenuate the elevation of p-STAT3 in NRVMs with AMO-124 transfection.	amo-124	88-95	signal transducer and activator of transcription 3	Mus musculus	0-5
30439699-14	2018	STAT3 inhibitor, stattic, was shown to attenuate the elevation of p-STAT3 in NRVMs with AMO-124 transfection.	amo-124	88-95	signal transducer and activator of transcription 3	Mus musculus	68-73
30439699-15	2018	Inhibiting of STAT3 activity by stattic abrogated protective effects of AMO-124 on H2O2-induced cardiomyocytes apoptosis.	amo-124	72-79	signal transducer and activator of transcription 3	Mus musculus	14-19
30439699-15	2018	Inhibiting of STAT3 activity by stattic abrogated protective effects of AMO-124 on H2O2-induced cardiomyocytes apoptosis.	Hydrogen Peroxide	83-87	signal transducer and activator of transcription 3	Mus musculus	14-19
29843136-11	2018	Furthermore, we found that ASP markedly suppressed the expression of interleukin-6 (IL-6), JAK2, p-STAT3, and p-SMAD1/5/8 in liver, suggesting that JAK/STAT and BMP-SMAD pathways were involved in the regulation of hepcidin expression by ASP.	Aspartic Acid	27-30	signal transducer and activator of transcription 3	Mus musculus	99-104
29794468-0	2018	Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma.	allicin	0-7	signal transducer and activator of transcription 3	Mus musculus	84-89
29794468-10	2018	RESULTS: Allicin significantly suppressed CCA cell proliferation by activating the caspase cascade, inducing apoptosis, and reducing the expression of proteins downstream of STAT3, such as B-cell lymphoma 2 (Bcl-2), while upregulating Bcl-2-associated X (Bax) protein.	allicin	9-16	signal transducer and activator of transcription 3	Mus musculus	174-179
29794468-13	2018	Mechanistic investigations indicated that allicin upregulated SHP-1 expression in CCA, and pervanadate treatment reversed the allicin-induced downregulation of STAT3.	pervanadate	91-102	signal transducer and activator of transcription 3	Mus musculus	160-165
29794468-13	2018	Mechanistic investigations indicated that allicin upregulated SHP-1 expression in CCA, and pervanadate treatment reversed the allicin-induced downregulation of STAT3.	allicin	126-133	signal transducer and activator of transcription 3	Mus musculus	160-165
29794468-14	2018	Moreover, suppression of SHP-1 by siRNA overturned the effect of allicin on the induction of SHP-1 and inhibition of STAT3 activation.	allicin	65-72	signal transducer and activator of transcription 3	Mus musculus	117-122
29794468-16	2018	CONCLUSIONS: Our findings suggest that allicin suppresses cell proliferation and invasion via STAT3 signaling and may be a potential therapeutic agent for CCA.	allicin	39-46	signal transducer and activator of transcription 3	Mus musculus	94-99
29763909-7	2018	RESULTS: After DOCA-salt treatment, the expression of SOCS3, activation of gp130/JAK/STAT3, cardiac dysfunction and fibrosis in DOCA-salt mice were significantly elevated, which were markedly attenuated by eplerenone, a specific mineralocorticoid receptor (MR) blocker.	Desoxycorticosterone Acetate	15-19	signal transducer and activator of transcription 3	Mus musculus	85-90
29763909-7	2018	RESULTS: After DOCA-salt treatment, the expression of SOCS3, activation of gp130/JAK/STAT3, cardiac dysfunction and fibrosis in DOCA-salt mice were significantly elevated, which were markedly attenuated by eplerenone, a specific mineralocorticoid receptor (MR) blocker.	Salts	20-24	signal transducer and activator of transcription 3	Mus musculus	85-90
29311992-0	2017	Empagliflozin Limits Myocardial Infarction in Vivo and Cell Death in Vitro: Role of STAT3, Mitochondria, and Redox Aspects.	empagliflozin	0-13	signal transducer and activator of transcription 3	Mus musculus	84-89
28881473-4	2018	The expressions of membrane-bound IL-6R (mIL-6R), sIL-6R and gp130 are enhanced in kidney cortex of diabetic mice accompanying with activated STAT3 by tyrosine 705 residue phosphorylation, while not serine 727.	Tyrosine	151-159	signal transducer and activator of transcription 3	Mus musculus	142-147
29789104-7	2018	Flow cytotmetry was used to quantify the induced level of apoptosis and measure the intracellular level of activated STAT3 (pSTAT3) following silibinin treatment in B16.F10 cells.	Silybin	142-151	signal transducer and activator of transcription 3	Mus musculus	117-122
29789104-9	2018	RESULTS: Silibinin inhibited cell proliferation (IC50 = 67 microM), provoked cell cycle arrest, induced apoptosis, suppressed key oncogenic pathways (i.e STAT3 and MEK/ERK), and enhanced the cytotoxic effects of doxorubicin in B16-F10 cells.	Silybin	9-18	signal transducer and activator of transcription 3	Mus musculus	154-159
29311992-8	2017	STAT3 was increased in parallel with reduced levels of malondialdehyde (MDA) and reduced expression of myocardial iNOS and interleukin-6.	Malondialdehyde	55-70	signal transducer and activator of transcription 3	Mus musculus	0-5
29096170-4	2017	Meanwhile, MOTS-c inhibited the phosphorylation mitogen-activated protein kinases (MAPK), and enhanced the expression of aryl hydrocarbon receptor (AhR) and signal transducer and activator of transcriptional 3 (STAT3) in macrophages.	UNII-A5CV6JFB78	11-17	signal transducer and activator of transcription 3	Mus musculus	157-209
29285175-0	2017	Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-kappaB and STAT3 signaling pathway.	Quercetin	0-9	signal transducer and activator of transcription 3	Mus musculus	104-109
29285175-0	2017	Quercetin prevents alcohol-induced liver injury through targeting of PI3K/Akt/nuclear factor-kappaB and STAT3 signaling pathway.	Alcohols	19-26	signal transducer and activator of transcription 3	Mus musculus	104-109
29285175-6	2017	These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-kappaB and STAT3 pathway.	Quercetin	52-61	signal transducer and activator of transcription 3	Mus musculus	156-161
29285175-6	2017	These results suggested that the protective role of quercetin prevents alcohol-induced liver injury through the phosphoinositide 3-kinase/Akt/NF-kappaB and STAT3 pathway.	Alcohols	71-78	signal transducer and activator of transcription 3	Mus musculus	156-161
29233151-5	2017	Al2O3 NPs exposure led to suppression of PTPN6 and phosphorylation of STAT3, culminating in increased expression of the apoptotic marker PDCD4.	Aluminum Oxide	0-5	signal transducer and activator of transcription 3	Mus musculus	70-75
29096170-4	2017	Meanwhile, MOTS-c inhibited the phosphorylation mitogen-activated protein kinases (MAPK), and enhanced the expression of aryl hydrocarbon receptor (AhR) and signal transducer and activator of transcriptional 3 (STAT3) in macrophages.	UNII-A5CV6JFB78	11-17	signal transducer and activator of transcription 3	Mus musculus	211-216
28990048-0	2017	Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1beta expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells.	Chlorogenic Acid	0-16	signal transducer and activator of transcription 3	Mus musculus	120-125
29152660-0	2017	Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use.	nifuroxazide	43-55	signal transducer and activator of transcription 3	Mus musculus	23-28
29152660-4	2017	In the present study, the authors hypothesized that nifuroxazide, as the STAT3 inhibitor, treatment may attenuate the development of acute GvHD (aGvHD).	nifuroxazide	52-64	signal transducer and activator of transcription 3	Mus musculus	73-78
29152660-7	2017	Treatment with nifuroxazide inhibited the activation of STAT3, resulting in the regulation of the CD4+ T cells and CD4+CD25+ T cells and reduction of interferon-gamma and tumor necrosis factor-alpha levels.	nifuroxazide	15-27	signal transducer and activator of transcription 3	Mus musculus	56-61
29074644-6	2017	Following renal IR injury, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at serine 727 and tyrosine 705 increased downstream from ERK1/2 activation.	Serine	108-114	signal transducer and activator of transcription 3	Mus musculus	46-96
29032686-0	2017	3"-Hydroxypterostilbene Suppresses Colitis-Associated Tumorigenesis by Inhibition of IL-6/STAT3 Signaling in Mice.	3'-hydroxypterostilbene	0-23	signal transducer and activator of transcription 3	Mus musculus	90-95
29074644-6	2017	Following renal IR injury, phosphorylation of signal transducer and activator of transcription 3 (STAT3) at serine 727 and tyrosine 705 increased downstream from ERK1/2 activation.	Serine	108-114	signal transducer and activator of transcription 3	Mus musculus	98-103
29074644-9	2017	These findings reveal renal ERK1/2 as an important initial regulator of KIM-1 expression in IR and septic AKI and at a physiologic level.Visual Abstract.Proposed mechanism of IR, LPS, and ROS-induced renal damage that initiates ERK1/2 and STAT3 phosphorylation.	ros	188-191	signal transducer and activator of transcription 3	Mus musculus	239-244
29052076-0	2017	(E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway.	Phenol	53-59	signal transducer and activator of transcription 3	Mus musculus	120-125
29052076-9	2017	Moreover, MMPP treatment suppressed DNA binding activities of the activation of STAT3 in in vivo and in vitro.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	10-14	signal transducer and activator of transcription 3	Mus musculus	80-85
29052076-10	2017	These results indicated that MMPP inhibits LPS-induced amyloidogenesis and neuroinflammation via inhibition of STAT3.	2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol	29-33	signal transducer and activator of transcription 3	Mus musculus	111-116
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Pyruvic Acid	55-63	signal transducer and activator of transcription 3	Mus musculus	29-34
29078279-8	2017	Importantly, increased H2O2 served as a second messenger and led to the STAT3 dimerization and, hence, activation of antiapoptotic signaling, which eventually significantly suppressed the superoxide burst and decreased the infarct size during the I/R process in cHet mice.	Hydrogen Peroxide	23-27	signal transducer and activator of transcription 3	Mus musculus	72-77
29078279-8	2017	Importantly, increased H2O2 served as a second messenger and led to the STAT3 dimerization and, hence, activation of antiapoptotic signaling, which eventually significantly suppressed the superoxide burst and decreased the infarct size during the I/R process in cHet mice.	Superoxides	188-198	signal transducer and activator of transcription 3	Mus musculus	72-77
28888052-13	2017	Treatment with SFP mitigated the effect of alcohol on miR-21, Smad7 and total and phosphorylated STAT3, and restored Nrf2-regulated antioxidant gene expression.	Alcohols	43-50	signal transducer and activator of transcription 3	Mus musculus	97-102
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Acetyl Coenzyme A	204-214	signal transducer and activator of transcription 3	Mus musculus	29-34
29109438-4	2017	VSIG4 activates the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, mitochondrial reactive oxygen species secretion, and macrophage inhibition.	Reactive Oxygen Species	241-264	signal transducer and activator of transcription 3	Mus musculus	29-34
28832962-8	2017	CONCLUSIONS AND IMPLICATIONS: These findings suggest that rubiarbonone C inhibits the proliferation and migration of VSMCs by inhibiting the FAK, MAPK and STAT3 signalling pathways.	rubiarbonone C	58-72	signal transducer and activator of transcription 3	Mus musculus	155-160
29061812-12	2017	In an LPS 863 cell xenograft mouse model treated with 17AAG, we observed that tumor size was decreasing, as well as down-regulation of the expression levels of vascular endothelial growth factor receptor 2 (VEGFR2), CD31 and signal transducer and activator of transcription-3 (STAT3).	tanespimycin	54-59	signal transducer and activator of transcription 3	Mus musculus	225-275
29061812-12	2017	In an LPS 863 cell xenograft mouse model treated with 17AAG, we observed that tumor size was decreasing, as well as down-regulation of the expression levels of vascular endothelial growth factor receptor 2 (VEGFR2), CD31 and signal transducer and activator of transcription-3 (STAT3).	tanespimycin	54-59	signal transducer and activator of transcription 3	Mus musculus	277-282
28832962-0	2017	Rubiarbonone C inhibits platelet-derived growth factor-induced proliferation and migration of vascular smooth muscle cells through the focal adhesion kinase, MAPK and STAT3 Tyr705 signalling pathways.	rubiarbonone C	0-14	signal transducer and activator of transcription 3	Mus musculus	167-172
28910744-8	2017	The ERK1/2 inhibitor U0126, the P38 inhibitor SB239063 and the STAT3 inhibitor S3I-201 all attenuated the effects of AGEs on MLO-Y4 cell apoptosis and IL-6 and VEGF-A secretion.	NSC 74859	79-86	signal transducer and activator of transcription 3	Mus musculus	63-68
29078883-8	2017	In a murine breast cancer model, sphingosine kinase 1, S1P receptor 1, interleukin 6, and STAT3 were overexpressed in the doxorubicin-treated group, whereas all of them were significantly suppressed with addition of FTY720.	Doxorubicin	122-133	signal transducer and activator of transcription 3	Mus musculus	90-95
29051215-7	2017	Using in vivo drug administration and primary cardiomyocyte culture, we also show that the cardiosafety of erlotinib treatment may result from upregulation of the cardioprotective signal transducer and activator of transcription 3 pathway, as co-treatment with erlotinib and a signal transducer and activator of transcription inhibitor decreases cardiac contractile function and cardiomyocyte fatty acid oxidation.	Erlotinib Hydrochloride	107-116	signal transducer and activator of transcription 3	Mus musculus	180-230
29238104-7	2017	Furthermore, the effects of IPA on IS-induced expression and phosphorylation of signal transducer and activator of transcription 3 (Stat3) were studied in HK-2 cells.	ipa	28-31	signal transducer and activator of transcription 3	Mus musculus	80-130
29238104-7	2017	Furthermore, the effects of IPA on IS-induced expression and phosphorylation of signal transducer and activator of transcription 3 (Stat3) were studied in HK-2 cells.	ipa	28-31	signal transducer and activator of transcription 3	Mus musculus	132-137
29238104-10	2017	IPA suppressed the IS-induced expression and phosphorylation of Stat3 in HK-2 cells.	ipa	0-3	signal transducer and activator of transcription 3	Mus musculus	64-69
29238104-12	2017	In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells.	ipa	15-18	signal transducer and activator of transcription 3	Mus musculus	116-121
29238104-12	2017	In conclusion, IPA suppressed the IS-induced expression of AHR, CYP1A1, TGF-beta1, and MCP-1 through suppression of Stat3 in proximal tubular cells.	Indican	34-36	signal transducer and activator of transcription 3	Mus musculus	116-121
28887131-11	2017	We indicate that IP receptor activation with PGI2 mimetics can rescue the damage in the liver induced by LPS/GalN by undermining activation of STAT3 and leading to a lower production of ROS.	Epoprostenol	45-49	signal transducer and activator of transcription 3	Mus musculus	143-148
29263930-0	2017	STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia.	N-caproylsphingosine	15-26	signal transducer and activator of transcription 3	Mus musculus	0-5
29263930-11	2017	Taken together, these findings provide the first body of evidence demonstrating ceramide regulation of STAT3 phosphorylation.	Ceramides	80-88	signal transducer and activator of transcription 3	Mus musculus	103-108
28561205-0	2017	Treatment with Mountain-Cultivated Ginseng Alleviates Trimethyltin-Induced Cognitive Impairments in Mice via IL-6-Dependent JAK2/STAT3/ERK Signaling.	trimethyltin	54-66	signal transducer and activator of transcription 3	Mus musculus	129-134
29051215-7	2017	Using in vivo drug administration and primary cardiomyocyte culture, we also show that the cardiosafety of erlotinib treatment may result from upregulation of the cardioprotective signal transducer and activator of transcription 3 pathway, as co-treatment with erlotinib and a signal transducer and activator of transcription inhibitor decreases cardiac contractile function and cardiomyocyte fatty acid oxidation.	Erlotinib Hydrochloride	261-270	signal transducer and activator of transcription 3	Mus musculus	180-230
29022919-0	2017	DCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway.	DCZ3301	0-7	signal transducer and activator of transcription 3	Mus musculus	98-103
29254203-5	2017	Consistently, PROS reduced the growth of H460 cells implanted in BALB/c athymic nude mice via inhibition of STAT3, and VEGF and activation of caspase 3.	Proline	14-18	signal transducer and activator of transcription 3	Mus musculus	108-113
28581518-0	2017	Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3.	honokiol	39-47	signal transducer and activator of transcription 3	Mus musculus	130-135
29022919-6	2017	DCZ3301 exerted an antitumor effect through modulation of Akt, extracellular signal-regulated kinases 1/2 (ERK1/2) and janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathways.	DCZ3301	0-7	signal transducer and activator of transcription 3	Mus musculus	141-191
29022919-6	2017	DCZ3301 exerted an antitumor effect through modulation of Akt, extracellular signal-regulated kinases 1/2 (ERK1/2) and janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathways.	DCZ3301	0-7	signal transducer and activator of transcription 3	Mus musculus	193-198
29022919-7	2017	Furthermore, DCZ3301 downregulates STAT3 phosphorylation by inhibiting Lck/Yes-related novel protein tyrosine kinase (Lyn) activation in DLBCL.	DCZ3301	13-20	signal transducer and activator of transcription 3	Mus musculus	35-40
28974499-7	2017	To determine whether the STAT3 (signal transducer and activator of transcription 3) pathway mediates the effect of IL-22 on blood pressure regulation, the special STAT3 pathway inhibitor S31-201 was administered to mice treated with recombinant IL-22.	NSC 74859	187-194	signal transducer and activator of transcription 3	Mus musculus	163-168
28967875-9	2017	Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway.	Curcumin	20-28	signal transducer and activator of transcription 3	Mus musculus	132-137
29085226-0	2017	STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury.	Thioacetamide	85-98	signal transducer and activator of transcription 3	Mus musculus	0-5
28967875-9	2017	Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway.	epigallocatechin gallate	46-50	signal transducer and activator of transcription 3	Mus musculus	132-137
28967875-0	2017	Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway.	Curcumin	12-20	signal transducer and activator of transcription 3	Mus musculus	131-136
28810537-0	2017	Cilostazol protects mice against myocardium ischemic/reperfusion injury by activating a PPARgamma/JAK2/STAT3 pathway.	Cilostazol	0-10	signal transducer and activator of transcription 3	Mus musculus	103-108
28967875-0	2017	Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway.	epigallocatechin gallate	25-55	signal transducer and activator of transcription 3	Mus musculus	131-136
28810537-12	2017	The results present a novel signaling mechanism that cilostazol protects MIR injury by activating a PPARgamma/JAK2/STAT3 pathway.	Cilostazol	53-63	signal transducer and activator of transcription 3	Mus musculus	115-120
28810537-9	2017	PPARgamma, JAK2 and STAT3 were all activated by cilostazol.	Cilostazol	48-58	signal transducer and activator of transcription 3	Mus musculus	20-25
29103460-9	2017	Ginsenoside Rk1 inhibited the lipopolysaccharide-stimulated phosphorylation of NF-kappaB and janus kinase (Jak)2 and signal transducer and activator of transcription (Stat)3 at Ser727 and Tyr705.	Ginsenosides	0-11	signal transducer and activator of transcription 3	Mus musculus	117-173
29103460-0	2017	Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway.	Ginsenosides	0-11	signal transducer and activator of transcription 3	Mus musculus	125-130
29103460-10	2017	These data suggested that ginsenoside Rk1 could inhibit expression of inflammatory mediators and suppress inflammation further by blocking activation of NF-kappaB and the Jak2/Stat3 pathway in LPS-stimulated RAW264.7 cells.	Ginsenosides	26-37	signal transducer and activator of transcription 3	Mus musculus	176-181
28472825-0	2017	Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet.	Lycopene	0-8	signal transducer and activator of transcription 3	Mus musculus	60-65
28472825-8	2017	The administration of Lycopene notably prevented the expression and phosphorylation of STAT3 in livers of mice induced by HFD.	Lycopene	22-30	signal transducer and activator of transcription 3	Mus musculus	87-92
28472825-9	2017	The treatment of adenovirus carrying STAT3 significantly suppressed the decrease of Srebp-1c expression induced by Lycopene.	Lycopene	115-123	signal transducer and activator of transcription 3	Mus musculus	37-42
28472825-11	2017	In conclusion, in the current study, we found that Lycopene prevented STAT3 signaling and inhibited Srebp-1c and downstream gene expression, resulting in inhibition of lipid accumulation, inflammation, insulin resistance and metabolic dysfunction.	Lycopene	51-59	signal transducer and activator of transcription 3	Mus musculus	70-75
28688098-7	2017	These processes inhibited the LPS-induced activation (phosphorylation) of NF-kappaB and STAT-3, in turn blocked the transcriptional activation of inducible NO synthase (iNOS), interleukin-6 (IL-6), and TNF-alpha, and finally attenuated the productions of nitric oxide (NO), IL-6, and TNF-alpha.	Nitric Oxide	255-267	signal transducer and activator of transcription 3	Mus musculus	88-94
28716484-0	2017	The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line.	Temozolomide	126-138	signal transducer and activator of transcription 3	Mus musculus	31-36
28600752-7	2017	By measuring the downstream markers phospho-mTOR (p-mTOR)/mTOR and phospho-signal transducer and activator of transcription 3 (p-STAT3)/STAT3, we showed that rapamycin suppressed the mTOR-STAT3 pathway in EAE mice.	Sirolimus	158-167	signal transducer and activator of transcription 3	Mus musculus	129-134
27722928-4	2017	In vitro analysis of activated microglia showed that HDAC inhibitor, sodium butyrate (SB), alters H3K9ac enrichment and transcription at the promoters of pro-inflammatory (Tnf-alpha, Nos2, Stat1, Il6) and anti-inflammatory (Il10) genes while inducing the expression of genes downstream of the IL10/STAT3 anti-inflammatory pathway.	Butyric Acid	69-84	signal transducer and activator of transcription 3	Mus musculus	298-303
27722928-4	2017	In vitro analysis of activated microglia showed that HDAC inhibitor, sodium butyrate (SB), alters H3K9ac enrichment and transcription at the promoters of pro-inflammatory (Tnf-alpha, Nos2, Stat1, Il6) and anti-inflammatory (Il10) genes while inducing the expression of genes downstream of the IL10/STAT3 anti-inflammatory pathway.	Butyric Acid	86-88	signal transducer and activator of transcription 3	Mus musculus	298-303
28688098-3	2017	The molecular mechanisms involved in the CaA-inhibited inflammatory response are very complex; generally, the down-regulated phosphorylation of such important transcriptional factors, for example, nuclear factor kappaB (NF-kappaB) and signal transducers and activators of transcription-3 (STAT-3), plays an important role.	caffeic acid	41-44	signal transducer and activator of transcription 3	Mus musculus	235-287
28688098-3	2017	The molecular mechanisms involved in the CaA-inhibited inflammatory response are very complex; generally, the down-regulated phosphorylation of such important transcriptional factors, for example, nuclear factor kappaB (NF-kappaB) and signal transducers and activators of transcription-3 (STAT-3), plays an important role.	caffeic acid	41-44	signal transducer and activator of transcription 3	Mus musculus	289-295
28771727-0	2017	Salvianolic acids enhance cerebral angiogenesis and neurological recovery by activating JAK2/STAT3 signaling pathway after ischemic stroke in mice.	salvianolic acid	0-17	signal transducer and activator of transcription 3	Mus musculus	93-98
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	50-54	signal transducer and activator of transcription 3	Mus musculus	9-14
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	signal transducer and activator of transcription 3	Mus musculus	9-14
28771727-9	2017	The JAK2/STAT3 signaling pathway was activated by Sals in the angiogenesis process, and inhibition of JAK2/STAT3 signaling blocked the effects of Sals on post-stroke angiogenesis and neurological recovery as well as abolished the mediation of proangiogenic factors.	salvianolic acid	146-150	signal transducer and activator of transcription 3	Mus musculus	107-112
28771727-10	2017	In summary, these data suggest that Sals administration enhances cerebral angiogenesis and promotes neurological recovery after ischemic stroke, mediated by the activation of JAK2/STAT3 signaling pathway.	salvianolic acid	36-40	signal transducer and activator of transcription 3	Mus musculus	180-185
28600752-7	2017	By measuring the downstream markers phospho-mTOR (p-mTOR)/mTOR and phospho-signal transducer and activator of transcription 3 (p-STAT3)/STAT3, we showed that rapamycin suppressed the mTOR-STAT3 pathway in EAE mice.	Sirolimus	158-167	signal transducer and activator of transcription 3	Mus musculus	136-141
28600752-7	2017	By measuring the downstream markers phospho-mTOR (p-mTOR)/mTOR and phospho-signal transducer and activator of transcription 3 (p-STAT3)/STAT3, we showed that rapamycin suppressed the mTOR-STAT3 pathway in EAE mice.	Sirolimus	158-167	signal transducer and activator of transcription 3	Mus musculus	136-141
28827130-5	2017	Furthermore, local knockout of STAT3 by injection of the AAV-Cre-GFP into the VTA area of STAT3flox/flox mice also significantly impaired the acquisition of morphine CPP.	Morphine	157-165	signal transducer and activator of transcription 3	Mus musculus	31-36
28827130-5	2017	Furthermore, local knockout of STAT3 by injection of the AAV-Cre-GFP into the VTA area of STAT3flox/flox mice also significantly impaired the acquisition of morphine CPP.	Morphine	157-165	signal transducer and activator of transcription 3	Mus musculus	90-95
28848967-14	2017	The expression of DEC1, HIF-1alpha, STAT3 and VEGF in tumor tissues was down-regulated after curcumin treatment.	Curcumin	93-101	signal transducer and activator of transcription 3	Mus musculus	36-41
28848967-15	2017	Our results indicate that curcumin inhibits the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells, activating immune cells to secrete a large amount of cytokines, and down-regulating the DEC1, HIF-1alpha, VEGF and STAT3 signal transduction pathways.	Curcumin	26-34	signal transducer and activator of transcription 3	Mus musculus	240-245
29207662-7	2017	Our results point to a unique mechanism in which TAMs promote tumor cells that lack amplification of an oncogene common to the malignancy by up-regulating transcriptional expression of a distinct oncogene from the same gene family, and underscore the role of IL-6-independent activation of STAT3 in this mechanism.	tams	49-53	signal transducer and activator of transcription 3	Mus musculus	290-295
29207668-2	2017	Here, gefitinib, a highly selective EGFR inhibitor, abrogated LPS-induced phosphorylation of EGFR, ERK1/2, and STAT3 as well as expression of COX, eNOS, and proinflammatory cytokines in HK-2 cells.	Gefitinib	6-15	signal transducer and activator of transcription 3	Mus musculus	111-116
29207668-5	2017	Interestingly, the beneficial effects of gefitinib or genetic approaches were accompanied by the dephosphorylation of EGFR, ERK1/2, and STAT3, the down regulation of expression of COX, eNOS, macrophage infiltration, proinflammatory cytokines production and the renal cell apoptosis.	Gefitinib	41-50	signal transducer and activator of transcription 3	Mus musculus	136-141
28687621-6	2017	In a mouse model of orthotopically implanted neuroblastoma cells, inhibition of JAK2/STAT3 and MEK/ERK/1/2 by ruxolitinib and trametinib potentiated tumor response to etoposide and increased overall survival.	ruxolitinib	110-121	signal transducer and activator of transcription 3	Mus musculus	85-90
28687621-6	2017	In a mouse model of orthotopically implanted neuroblastoma cells, inhibition of JAK2/STAT3 and MEK/ERK/1/2 by ruxolitinib and trametinib potentiated tumor response to etoposide and increased overall survival.	trametinib	126-136	signal transducer and activator of transcription 3	Mus musculus	85-90
29254150-0	2017	Novel allylated monocarbonyl analogs of curcumin induce mitotic arrest and apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and inhibition of STAT3.	Curcumin	40-48	signal transducer and activator of transcription 3	Mus musculus	168-173
29152090-8	2017	In agreement with results from our in vitro experiments, GpS suppressed cytokine production and activation of NF-kappaB and STAT3 signaling in the colons of DSS-induced mice.	Dextran Sulfate	157-160	signal transducer and activator of transcription 3	Mus musculus	124-129
29018490-9	2017	The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran.	pg-lps	52-58	signal transducer and activator of transcription 3	Mus musculus	13-18
29018490-9	2017	The TLR2 and STAT3 gene expression increased by the Pg-LPS administration but decreased with eritoran.	eritoran	93-101	signal transducer and activator of transcription 3	Mus musculus	13-18
28583713-8	2017	Treatment with NT157 inhibited the phosphorylation of IGF-1R and STAT3 in synovia, and alleviated arthritis and joint damage in mice.	NT157	15-20	signal transducer and activator of transcription 3	Mus musculus	65-70
29100426-5	2017	In addition, PHS-based inhibition of EMT was attributable to the downregulation of the EGFR/JAK1/STAT3 signaling axis, as validated by immunoprecipitation assays and breast tumorigenesis mice models.	D-ribo-phytosphingosine	13-16	signal transducer and activator of transcription 3	Mus musculus	97-102
28608285-9	2017	In vitro analysis showed that, in macrophages from Apoe -/- Irs2 +/- mice, lixisenatide reduced the secretion of the proinflammatory cytokine IL-6 accompanied by enhanced activation of signal transducer and activator of transcription (STAT) 3, which is a determinant for M2 macrophage differentiation.	lixisenatide	75-87	signal transducer and activator of transcription 3	Mus musculus	185-242
28622591-0	2017	Targeting proinflammatory cytokines, oxidative stress, TGF-beta1 and STAT-3 by rosuvastatin and ubiquinone to ameliorate trastuzumab cardiotoxicity.	Rosuvastatin Calcium	79-91	signal transducer and activator of transcription 3	Mus musculus	69-75
28622591-7	2017	Administration of rosuvastatin and/or ubiquinone to TRZ-treated mice induced significant increase in tissue GPx, CAT and STAT-3 with significant decrease in serum CK-MB, LDH, troponin I, NT-pro BNP, tissue MDA, TGF-beta1 and IL-6 and improved the histopathological, immunohistochemical, echocardiographic and electron microscopic changes compared to the group that received TRZ alone.	Rosuvastatin Calcium	18-30	signal transducer and activator of transcription 3	Mus musculus	121-127
28622591-7	2017	Administration of rosuvastatin and/or ubiquinone to TRZ-treated mice induced significant increase in tissue GPx, CAT and STAT-3 with significant decrease in serum CK-MB, LDH, troponin I, NT-pro BNP, tissue MDA, TGF-beta1 and IL-6 and improved the histopathological, immunohistochemical, echocardiographic and electron microscopic changes compared to the group that received TRZ alone.	Ubiquinone	38-48	signal transducer and activator of transcription 3	Mus musculus	121-127
28655070-0	2017	Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3.	carnosol	21-29	signal transducer and activator of transcription 3	Mus musculus	96-101
28655070-0	2017	Inhibitory Effect of Carnosol on Phthalic Anhydride-Induced Atopic Dermatitis via Inhibition of STAT3.	phthalic anhydride	33-51	signal transducer and activator of transcription 3	Mus musculus	96-101
28655070-5	2017	In addition, carnosol effectively inhibits the phosphorylation of STAT3 and DNA binding activity in RAW 264.7 cells.	carnosol	13-21	signal transducer and activator of transcription 3	Mus musculus	66-71
28655070-6	2017	Pull down assay and docking model analysis showed that carnosol directly binds to the DNA binding domain (DBD) of STAT3.	carnosol	55-63	signal transducer and activator of transcription 3	Mus musculus	114-119
28655070-11	2017	Furthermore, the activation of STAT3 in skin tissue was decreased in carnosol treated mice compared with control mice.	carnosol	69-77	signal transducer and activator of transcription 3	Mus musculus	31-36
28655070-12	2017	In conclusion, these findings suggest that carnosol exhibited a potential anti-AD activity by inhibiting pro-inflammatory mediators through suppression of STAT3 activation via direct binding to DBD of STAT3.	carnosol	43-51	signal transducer and activator of transcription 3	Mus musculus	155-160
28655070-12	2017	In conclusion, these findings suggest that carnosol exhibited a potential anti-AD activity by inhibiting pro-inflammatory mediators through suppression of STAT3 activation via direct binding to DBD of STAT3.	carnosol	43-51	signal transducer and activator of transcription 3	Mus musculus	201-206
28666887-0	2017	Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-kappaB activation.	stevioside	11-21	signal transducer and activator of transcription 3	Mus musculus	93-98
28962142-0	2017	Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression.	Selenium	11-19	signal transducer and activator of transcription 3	Mus musculus	87-92
28522594-4	2017	DSS treatment induced a significant increase in ceramide levels, with a decrease of SM levels in SMS2-/- colon tissue, and demonstrated attenuation of the elevation of both inflammation-related gene expression and proinflammatory cytokines and chemokines, leukocyte infiltration, and MAPK and signal transducer and activator of transcription 3 activation.	dss	0-3	signal transducer and activator of transcription 3	Mus musculus	293-343
28962142-6	2017	Low selenium treatment reduced the expression of p-STAT3, but did not affect the expression of STAT3.	Selenium	4-12	signal transducer and activator of transcription 3	Mus musculus	51-56
28962142-7	2017	In addition, low selenium treatment reduced the activity of mitochondrial STAT3 and succinate dehydrogenase in cardiomyocytes, leading to injury of myocardial mitochondria.	Selenium	17-25	signal transducer and activator of transcription 3	Mus musculus	74-79
28962142-11	2017	In conclusion, selenium deficiency in cardiomyocytes leads to decreased potassium channel expression and decreased mitochondrial STAT3 activity and mitochondrial function, which in turn promotes the apoptosis of cardiomyocytes.	Selenium	15-23	signal transducer and activator of transcription 3	Mus musculus	129-134
28684161-10	2017	gamma-Tocotrienol acted by inhibiting nuclear translocation of STAT3 and NF-kappaB, and up-regulating Nrf2 activation in the lungs.	plastochromanol 8	0-17	signal transducer and activator of transcription 3	Mus musculus	63-68
28666887-0	2017	Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-kappaB activation.	Cisplatin	38-47	signal transducer and activator of transcription 3	Mus musculus	93-98
28666887-9	2017	Both SE and stevioside attenuated CP nephrotoxicity by suppressing oxidative stress, inflammation, and apoptosis through mechanism involving ERK1/2, STAT3, and NF-kappaB suppression.	stevioside	12-22	signal transducer and activator of transcription 3	Mus musculus	149-154
28480882-5	2017	We found that microglia-specific STAT3 KO mice showed antidepressive-like behavior in the forced swim, tail suspension, sucrose preference, and open-field tests.	Sucrose	120-127	signal transducer and activator of transcription 3	Mus musculus	33-38
28332288-0	2017	Tetrandrine, an agonist of aryl hydrocarbon receptor, reciprocally modulates the activities of STAT3 and STAT5 to suppress Th17 cell differentiation.	tetrandrine	0-11	signal transducer and activator of transcription 3	Mus musculus	95-100
28332288-4	2017	Tetrandrine inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and boosted the phosphorylation of STAT5, while it did not alter the expression levels of phospho-Janus kinase-1 (p-JAK1), p-JAK2, p-JAK3, and suppressor of cytokine signalling-3 (SOCS3).	tetrandrine	0-11	signal transducer and activator of transcription 3	Mus musculus	45-95
28332288-4	2017	Tetrandrine inhibited the phosphorylation of signal transducer and activator of transcription-3 (STAT3) and boosted the phosphorylation of STAT5, while it did not alter the expression levels of phospho-Janus kinase-1 (p-JAK1), p-JAK2, p-JAK3, and suppressor of cytokine signalling-3 (SOCS3).	tetrandrine	0-11	signal transducer and activator of transcription 3	Mus musculus	97-102
28332288-5	2017	The tetrandrine-mediated inhibition of the Th17 cell differentiation could be diminished by the activator of STAT3 and the inhibitor of STAT5.	tetrandrine	4-15	signal transducer and activator of transcription 3	Mus musculus	109-114
28332288-6	2017	Meanwhile, the effect of tetrandrine on the either STAT3 or STAT5 phosphorylation was almost completely reversed by the AhR antagonist CH223191 and the AhR knockdown.	tetrandrine	25-36	signal transducer and activator of transcription 3	Mus musculus	51-56
28332288-6	2017	Meanwhile, the effect of tetrandrine on the either STAT3 or STAT5 phosphorylation was almost completely reversed by the AhR antagonist CH223191 and the AhR knockdown.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	135-143	signal transducer and activator of transcription 3	Mus musculus	51-56
28332288-7	2017	In CIA mice, tetrandrine decreased p-STAT3 levels and increased p-STAT5 levels, which could also be reversed by the AhR antagonist resveratrol administration.	tetrandrine	13-24	signal transducer and activator of transcription 3	Mus musculus	37-42
28332288-7	2017	In CIA mice, tetrandrine decreased p-STAT3 levels and increased p-STAT5 levels, which could also be reversed by the AhR antagonist resveratrol administration.	Resveratrol	131-142	signal transducer and activator of transcription 3	Mus musculus	37-42
28332288-9	2017	The tetrandrine-induced inhibition of the STAT3 phosphorylation was diminished by the inhibitor of STAT5.	tetrandrine	4-15	signal transducer and activator of transcription 3	Mus musculus	42-47
28332288-10	2017	Taken together, tetrandrine suppressed Th17 cell differentiation by reciprocally modulating the activities of STAT3 and STAT5 in an AhR-dependent manner.	tetrandrine	16-27	signal transducer and activator of transcription 3	Mus musculus	110-115
28647611-7	2017	In addition, we observed that isoprenaline induced the up-regulation of the intratumoral expression of phosphorylated mTOR, phosphorylated ERK1/2, phosphorylated Tyr705-STAT3 and HIF-1alpha, whereas rapamycin induced an opposite effect on the same molecules and could abolish the effects of isoprenaline.	Isoproterenol	30-42	signal transducer and activator of transcription 3	Mus musculus	169-174
28695568-5	2017	We found that PRMT1 methylates arginine residue(s) of STAT3 to regulate its activity positively, resulting in the promotion of astrocytic differentiation of NS/PCs.	Arginine	31-39	signal transducer and activator of transcription 3	Mus musculus	54-59
28955792-0	2017	STAT3 and NF-kappaB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema.	kaempferol	43-53	signal transducer and activator of transcription 3	Mus musculus	0-5
28955792-0	2017	STAT3 and NF-kappaB are common targets for kaempferol-mediated attenuation of COX-2 expression in IL-6-induced macrophages and carrageenan-induced mouse paw edema.	Carrageenan	127-138	signal transducer and activator of transcription 3	Mus musculus	0-5
28955792-3	2017	Kaempferol deactivated and prevented nuclear localization of two major transcription factors STAT3 and NF-kappaB, mutually responsible for COX-2 induction in response to IL-6.	kaempferol	0-10	signal transducer and activator of transcription 3	Mus musculus	93-98
28955792-4	2017	Moreover, STAT3 and NF-kappaB were simultaneously deactivated by kaempferol in acute inflammation, as shown by carrageenan-induced mouse paw edema model.	kaempferol	65-75	signal transducer and activator of transcription 3	Mus musculus	10-15
28955792-4	2017	Moreover, STAT3 and NF-kappaB were simultaneously deactivated by kaempferol in acute inflammation, as shown by carrageenan-induced mouse paw edema model.	Carrageenan	111-122	signal transducer and activator of transcription 3	Mus musculus	10-15
28606477-0	2017	N-3 polyunsaturated fatty acid-enriched lipid emulsion improves Paneth cell function via the IL-22/Stat3 pathway in a mouse model of total parenteral nutrition.	Fatty Acids, Omega-3	0-30	signal transducer and activator of transcription 3	Mus musculus	99-104
29207645-0	2017	Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3.	nitidine	0-17	signal transducer and activator of transcription 3	Mus musculus	125-130
29088814-8	2017	Decreasing adenosine inhibitted M2 polarization of RAW264.7 cells through inactivating JAK1/STAT3 signal pathway in fasting condition.	Adenosine	11-20	signal transducer and activator of transcription 3	Mus musculus	92-97
28827748-0	2017	Calf Spleen Extractive Injection protects mice against cyclophosphamide-induced hematopoietic injury through G-CSF-mediated JAK2/STAT3 signaling.	Cyclophosphamide	55-71	signal transducer and activator of transcription 3	Mus musculus	129-134
28579428-6	2017	Biochanin A also induced tyrosine-phosphorylation of signal transducer and activator of transcription 3 (STAT3) in these cells.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	53-103
28848431-8	2017	PE administration significantly inhibited the activation of both NF-kappaB and STAT3 induced by DSS, while it elevated the accumulation of Nrf2 and heme oxygenase-1 in the colon.	pe	0-2	signal transducer and activator of transcription 3	Mus musculus	79-84
28848431-8	2017	PE administration significantly inhibited the activation of both NF-kappaB and STAT3 induced by DSS, while it elevated the accumulation of Nrf2 and heme oxygenase-1 in the colon.	Dextran Sulfate	96-99	signal transducer and activator of transcription 3	Mus musculus	79-84
28221800-0	2017	Self-Associating Poly(ethylene oxide)-block-poly(alpha-carboxyl-epsilon-caprolactone) Drug Conjugates for the Delivery of STAT3 Inhibitor JSI-124: Potential Application in Cancer Immunotherapy.	Polyethylene Glycols	17-36	signal transducer and activator of transcription 3	Mus musculus	122-127
28221800-2	2017	JSI-124 (cucurbitacin I) is a potent inhibitor of STAT3; however, its poor solubility and nonspecificity limit its effectiveness in cancer immunotherapy.	cucurbitacin I	0-7	signal transducer and activator of transcription 3	Mus musculus	50-55
28221800-2	2017	JSI-124 (cucurbitacin I) is a potent inhibitor of STAT3; however, its poor solubility and nonspecificity limit its effectiveness in cancer immunotherapy.	cucurbitacin I	9-23	signal transducer and activator of transcription 3	Mus musculus	50-55
28221800-6	2017	As expected, JSI-124 nanoconjugates showed lower potency in p-STAT3 inhibition and direct anticancer activity in B16-F10 melanoma cells.	jsi	13-16	signal transducer and activator of transcription 3	Mus musculus	62-67
28522406-0	2017	Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.	cryptotanshinone	22-38	signal transducer and activator of transcription 3	Mus musculus	113-118
28579428-6	2017	Biochanin A also induced tyrosine-phosphorylation of signal transducer and activator of transcription 3 (STAT3) in these cells.	Tyrosine	25-33	signal transducer and activator of transcription 3	Mus musculus	105-110
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	21-27	signal transducer and activator of transcription 3	Mus musculus	0-5
28806414-2	2017	The ALK inhibitor, crizotinib specifically induced apoptosis in Ba/F3 cells expressing NPM-ALK by inhibiting the activation of NPM-ALK and its downstream molecule, signal transducer and activator of transcription factor 3 (STAT3).	Crizotinib	19-29	signal transducer and activator of transcription 3	Mus musculus	164-221
28806414-2	2017	The ALK inhibitor, crizotinib specifically induced apoptosis in Ba/F3 cells expressing NPM-ALK by inhibiting the activation of NPM-ALK and its downstream molecule, signal transducer and activator of transcription factor 3 (STAT3).	Crizotinib	19-29	signal transducer and activator of transcription 3	Mus musculus	223-228
28771545-11	2017	Finally, administration of anti-IL-6 antibody abolished an increase in tyrosine phosphorylation of STAT3, a major signaling molecule downstream of IL-6, in the transgenic mouse heart and prevented development of cardiac hypertrophy in transgenic mice.	Tyrosine	71-79	signal transducer and activator of transcription 3	Mus musculus	99-104
28774345-8	2017	In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration.	PO-2	82-85	signal transducer and activator of transcription 3	Mus musculus	176-181
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	21-27	signal transducer and activator of transcription 3	Mus musculus	82-87
28637784-8	2017	Stat3 acetylation at lysine 370 or lysine 383 played a key role in the ability of Stat3 to form a supercomplex with RelA.	Lysine	35-41	signal transducer and activator of transcription 3	Mus musculus	82-87
28343944-10	2017	In primary melanoma cells from Tyr::Rack1-HA, Tyr::NRasQ61K mice, activated JNK (c-Jun N-terminal kinase) and activated STAT3 (signal transducer and activator of transcription 3) acted as RACK1 oncogenic partners in tumoral progression.	Tyrosine	31-34	signal transducer and activator of transcription 3	Mus musculus	120-125
28343944-10	2017	In primary melanoma cells from Tyr::Rack1-HA, Tyr::NRasQ61K mice, activated JNK (c-Jun N-terminal kinase) and activated STAT3 (signal transducer and activator of transcription 3) acted as RACK1 oncogenic partners in tumoral progression.	Tyrosine	31-34	signal transducer and activator of transcription 3	Mus musculus	127-177
28343944-10	2017	In primary melanoma cells from Tyr::Rack1-HA, Tyr::NRasQ61K mice, activated JNK (c-Jun N-terminal kinase) and activated STAT3 (signal transducer and activator of transcription 3) acted as RACK1 oncogenic partners in tumoral progression.	Tyrosine	46-49	signal transducer and activator of transcription 3	Mus musculus	120-125
28343944-10	2017	In primary melanoma cells from Tyr::Rack1-HA, Tyr::NRasQ61K mice, activated JNK (c-Jun N-terminal kinase) and activated STAT3 (signal transducer and activator of transcription 3) acted as RACK1 oncogenic partners in tumoral progression.	Tyrosine	46-49	signal transducer and activator of transcription 3	Mus musculus	127-177
28290050-2	2017	STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO114-b-PCL22) and methoxy poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate-epsilon-caprolactone) (PEO114-b-PBCL20) micelles using co-solvent evaporation.	methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone)	45-102	signal transducer and activator of transcription 3	Mus musculus	0-5
28555509-5	2017	Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation.	Propofol	0-8	signal transducer and activator of transcription 3	Mus musculus	133-138
28555509-5	2017	Propofol also suppressed the IL-6-induced phosphorylation of Janus kinase-2 (JAK2)/signal transducer and activator of transcription (STAT3) pathway, a cytokine-activated essential transcription factor in Th17 cell development, which occurred concomitantly with the enhancement of suppressor of cytokine signaling-3 (SOCS3) expression involved in the downregulation of STAT3 phosphorylation.	Propofol	0-8	signal transducer and activator of transcription 3	Mus musculus	368-373
28829493-10	2017	RESULTS: LPS model group had lower RBC, Hb, HCT, MCV and iron content in Hb, plus elevated hepcidin, IL-6, TNF-alpha, TfR2 and STAT3 expression (p &lt; 0.05 compared to the control group).	lps	9-12	signal transducer and activator of transcription 3	Mus musculus	127-132
28829493-11	2017	IL-10 treatment group significantly facilitated RBC, Hb, HCT, MCV and Hb iron contents in LPS-induced inflammatory model mice, which also had lower hepcidin, IL-6, TNF-alpha, TfR2 or STAT3 expression (p &lt; 0.05 compared to LPS group).	lps	90-93	signal transducer and activator of transcription 3	Mus musculus	183-188
28486600-6	2017	Embryonic kidney cyst formation of Sclt1-/- mice was effectively reduced by an anti-STAT3 treatment using pyrimethamine.	Pyrimethamine	106-119	signal transducer and activator of transcription 3	Mus musculus	84-89
28290050-2	2017	STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO114-b-PCL22) and methoxy poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate-epsilon-caprolactone) (PEO114-b-PBCL20) micelles using co-solvent evaporation.	peo114-b-pcl22	104-118	signal transducer and activator of transcription 3	Mus musculus	0-5
28290050-2	2017	STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO114-b-PCL22) and methoxy poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate-epsilon-caprolactone) (PEO114-b-PBCL20) micelles using co-solvent evaporation.	methoxy poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate-epsilon-caprolactone	124-205	signal transducer and activator of transcription 3	Mus musculus	0-5
28290050-2	2017	STAT3 inhibitory agents were encapsulated in methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO114-b-PCL22) and methoxy poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate-epsilon-caprolactone) (PEO114-b-PBCL20) micelles using co-solvent evaporation.	peo114-b-pbcl20	208-223	signal transducer and activator of transcription 3	Mus musculus	0-5
28290050-9	2017	Our findings show that both PCL- and PBCL-based polymeric micelles have potential for the solubilization and delivery of S3I-1757, a potent STAT3 inhibitory agent.	pbcl	37-41	signal transducer and activator of transcription 3	Mus musculus	140-145
28237879-9	2017	Astrogliosis was induced by H2O2 through a process in which extracellularly generated H2O2 diffused into the cytoplasm and subsequently stimulated activation of transcription factors, STAT1 and STAT3.	Hydrogen Peroxide	86-90	signal transducer and activator of transcription 3	Mus musculus	194-199
28500787-10	2017	Additionally, CORT exposure prior to DFP or CPO enhanced activation of the neuroinflammation signal transducer, signal transducer and activator of transcription 3 (STAT3).	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	44-47	signal transducer and activator of transcription 3	Mus musculus	164-169
28237879-9	2017	Astrogliosis was induced by H2O2 through a process in which extracellularly generated H2O2 diffused into the cytoplasm and subsequently stimulated activation of transcription factors, STAT1 and STAT3.	Hydrogen Peroxide	28-32	signal transducer and activator of transcription 3	Mus musculus	194-199
28595081-0	2017	Pioglitazone attenuates lipopolysaccharide-induced depression-like behaviors, modulates NF-kappaB/IL-6/STAT3, CREB/BDNF pathways and central serotonergic neurotransmission in mice.	Pioglitazone	0-12	signal transducer and activator of transcription 3	Mus musculus	103-108
28595081-7	2017	Moreover, Western blot analysis revealed the effects of PIO on inhibiting activation of the nuclear factor kappa B/interleukin 6/signal transducer and activator of transcription 3 (NF-kappaB/IL-6/STAT3) pathway, improving down-regulation of the cAMP response-element-binding protein/brain derived neurotrophic factor (CREB/BDNF) pathway, as well as regulating disturbed expression of proteins involved in central serotonergic neurotransmission following LPS administration.	Cyclic AMP	245-249	signal transducer and activator of transcription 3	Mus musculus	196-201
28533357-7	2017	The PMN-MDSCs from tetracycline-treated RM9-Tlr9ON tumors increased the immunosuppressive activity of the STAT3 transcription factor, thereby more potently inhibiting T cell proliferation.	Tetracycline	19-31	signal transducer and activator of transcription 3	Mus musculus	106-111
28533357-13	2017	Finally, targeting TLR9/LIF/STAT3 signaling using oligonucleotide-based inhibitors, such as CpG-STAT3dODN, can offer new opportunities for prostate cancer immunotherapy.	Oligonucleotides	50-65	signal transducer and activator of transcription 3	Mus musculus	28-33
28282360-10	2017	The in vitro findings suggest that GTS-21-induced IL-6 release from muscle is mediated via alpha7AChRs upstream of Stat-3 and -5 pathways and is associated with myonuclear accretion, possibly via MyoD and Pax7 expression.	3-(2,4-dimethoxybenzylidene)anabaseine	35-41	signal transducer and activator of transcription 3	Mus musculus	115-128
28747781-6	2017	Together these results for the first time demonstrated the anti-tumor effects of STAT3 inhibitor S3I-201 in HPV-negative ASCC mouse model and its multiple effects on cancer cells and immune system.	NSC 74859	97-104	signal transducer and activator of transcription 3	Mus musculus	81-86
29050290-5	2017	Our results suggested that the tumor suppressive effect of GMI was mediated through inhibition of IL-6/Stat3 signaling pathway.	misonidazole-glutathione conjugate	59-62	signal transducer and activator of transcription 3	Mus musculus	103-108
28750090-3	2017	METHODS AND FINDINGS: An in silico fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization.	Phosphotyrosine	155-170	signal transducer and activator of transcription 3	Mus musculus	138-143
29050290-0	2017	GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition.	misonidazole-glutathione conjugate	0-3	signal transducer and activator of transcription 3	Mus musculus	96-101
28319060-7	2017	Importantly, Ex-4 also downregulated epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3), which lie downstream of cAMP-PKA signaling, resulting in suppression of multiple STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.	Cyclic AMP	165-169	signal transducer and activator of transcription 3	Mus musculus	81-131
28319060-7	2017	Importantly, Ex-4 also downregulated epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3), which lie downstream of cAMP-PKA signaling, resulting in suppression of multiple STAT3-targeted genes including c-Myc, cyclin D1, survivin, Bcl-2 and Bcl-xl.	Cyclic AMP	165-169	signal transducer and activator of transcription 3	Mus musculus	133-138
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	signal transducer and activator of transcription 3	Mus musculus	142-147
29228558-0	2017	1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol ameliorates arthritic joints through reducing neutrophil infiltration mediated by IL-6/STAT3 and MIP-2 activation.	1-palmitoyl-2-linoleoyl-3-acetyl-rac glycerol	0-45	signal transducer and activator of transcription 3	Mus musculus	133-138
29228558-3	2017	In this study, we show that 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) decreases neutrophil migration by regulating the activity of STAT3, a regulator of IL-6 and MIP-2 expression.	1-palmitoyl-2-linoleoyl-3-acetyl-rac glycerol	28-73	signal transducer and activator of transcription 3	Mus musculus	142-147
28672024-10	2017	Furthermore, oral administration of Bazedoxifene significantly suppressed tumor growth and expression of STAT3 phosphorylation in nude mice bearing established human rhabdomyosarcoma xenograft.	bazedoxifene	36-48	signal transducer and activator of transcription 3	Mus musculus	105-110
28691428-7	2017	Our review also aims to acquaint a broad audience of internal medicine practitioners with the STAT3-related molecular mechanisms that underlie the therapeutic properties of such widely administered drugs as angiotensin II type 1 (AT1) receptor antagonists and HMG-CoA reductase inhibitors, such as losartan and lovastatin.	Losartan	298-306	signal transducer and activator of transcription 3	Mus musculus	94-99
28691428-7	2017	Our review also aims to acquaint a broad audience of internal medicine practitioners with the STAT3-related molecular mechanisms that underlie the therapeutic properties of such widely administered drugs as angiotensin II type 1 (AT1) receptor antagonists and HMG-CoA reductase inhibitors, such as losartan and lovastatin.	Lovastatin	311-321	signal transducer and activator of transcription 3	Mus musculus	94-99
28319060-0	2017	The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.	Exenatide	23-32	signal transducer and activator of transcription 3	Mus musculus	133-138
28319060-0	2017	The anti-diabetic drug exenatide, a glucagon-like peptide-1 receptor agonist, counteracts hepatocarcinogenesis through cAMP-PKA-EGFR-STAT3 axis.	Cyclic AMP	119-123	signal transducer and activator of transcription 3	Mus musculus	133-138
28400195-19	2017	Administration of recombinant IL6 to LysM-Cre; Egfrf/f mice given DSS protected them from weight loss and restored epithelial proliferation and STAT3 activation, compared with administration of DSS alone to these mice.	dss	66-69	signal transducer and activator of transcription 3	Mus musculus	144-149
28534932-0	2017	Inhibition of prostate cancer RM1 cell growth in vitro by hydroxyapatite nanoparticle-delivered short hairpin RNAs against Stat3.	Durapatite	58-72	signal transducer and activator of transcription 3	Mus musculus	123-128
28409189-9	2017	In addition, we found that daphnetin suppressed the activation of JAK/STATs pathway and inhibited the nucleus import of STAT1 and STAT3.	daphnetin	27-36	signal transducer and activator of transcription 3	Mus musculus	130-135
28230281-5	2017	Finally, enhanced activation of JAK/STAT3 signaling pathway and suppressed activation of mTOR were found essential in enhancing the self-renewal of ESCs by RSV.	Resveratrol	156-159	signal transducer and activator of transcription 3	Mus musculus	36-41
28727705-10	2017	and STAT3 activity inhibitor S3I-201 (i.t.)	NSC 74859	29-36	signal transducer and activator of transcription 3	Mus musculus	4-9
29228586-7	2017	Hypoxia-induced p-STAT3 increased the mRNA transcription of ICAM-1, which we could inhibit with the STAT3 inhibitor AZD1480.	AZD 1480	116-123	signal transducer and activator of transcription 3	Mus musculus	18-23
29228586-7	2017	Hypoxia-induced p-STAT3 increased the mRNA transcription of ICAM-1, which we could inhibit with the STAT3 inhibitor AZD1480.	AZD 1480	116-123	signal transducer and activator of transcription 3	Mus musculus	100-105
27628046-10	2017	AG-490 inhibited PDGF-BB-induced STAT3 phosphorylation.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	0-6	signal transducer and activator of transcription 3	Mus musculus	33-38
28522550-11	2017	Inhibition of miR-135b-5p can protect against myocardial I/R injury by activating JAK2/STAT3 signaling pathway through mediation of inhalation anesthesia with sevoflurane.	mir-135b	14-22	signal transducer and activator of transcription 3	Mus musculus	87-92
28522550-11	2017	Inhibition of miR-135b-5p can protect against myocardial I/R injury by activating JAK2/STAT3 signaling pathway through mediation of inhalation anesthesia with sevoflurane.	CHEMBL3740941	23-25	signal transducer and activator of transcription 3	Mus musculus	87-92
28522550-11	2017	Inhibition of miR-135b-5p can protect against myocardial I/R injury by activating JAK2/STAT3 signaling pathway through mediation of inhalation anesthesia with sevoflurane.	Sevoflurane	159-170	signal transducer and activator of transcription 3	Mus musculus	87-92
28903389-0	2017	Epithelial HO-1/STAT3 affords the protection of subanesthetic isoflurane against zymosan-induced lung injury in mice.	Isoflurane	62-72	signal transducer and activator of transcription 3	Mus musculus	16-21
28903389-0	2017	Epithelial HO-1/STAT3 affords the protection of subanesthetic isoflurane against zymosan-induced lung injury in mice.	Zymosan	81-88	signal transducer and activator of transcription 3	Mus musculus	16-21
28903389-4	2017	In this study, zymosan increased the expression and activity of beneficial heme oxygenase-1 (HO-1) and signal transducers and activators of transcription 3 (STAT3) in the lung and isolated type II alveolar epithelial cells (AECs-II) from wild-type (WT) mice, which was further enhanced by ISO treatment.	Zymosan	15-22	signal transducer and activator of transcription 3	Mus musculus	103-155
28903389-4	2017	In this study, zymosan increased the expression and activity of beneficial heme oxygenase-1 (HO-1) and signal transducers and activators of transcription 3 (STAT3) in the lung and isolated type II alveolar epithelial cells (AECs-II) from wild-type (WT) mice, which was further enhanced by ISO treatment.	Zymosan	15-22	signal transducer and activator of transcription 3	Mus musculus	157-162
28903389-7	2017	Mechanisticly, the epithelial protective effects of ISO on zymosan insult in vivo and in vitro were mediated by a positive feedback loop comprising STAT3 and HO-1.	Isoflurane	52-55	signal transducer and activator of transcription 3	Mus musculus	148-153
28903389-7	2017	Mechanisticly, the epithelial protective effects of ISO on zymosan insult in vivo and in vitro were mediated by a positive feedback loop comprising STAT3 and HO-1.	Zymosan	59-66	signal transducer and activator of transcription 3	Mus musculus	148-153
28903389-9	2017	Overall, HO-1/STAT3 signaling is in favor of lung epithelial protection of ISO in zymosan-challenged mice, suggesting ISO as a valuable therapeutic agent for ALI.	Isoflurane	75-78	signal transducer and activator of transcription 3	Mus musculus	14-19
28903389-9	2017	Overall, HO-1/STAT3 signaling is in favor of lung epithelial protection of ISO in zymosan-challenged mice, suggesting ISO as a valuable therapeutic agent for ALI.	Zymosan	82-89	signal transducer and activator of transcription 3	Mus musculus	14-19
28903389-9	2017	Overall, HO-1/STAT3 signaling is in favor of lung epithelial protection of ISO in zymosan-challenged mice, suggesting ISO as a valuable therapeutic agent for ALI.	Isoflurane	118-121	signal transducer and activator of transcription 3	Mus musculus	14-19
28489606-0	2017	Pantoprazole blocks the JAK2/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response.	Pantoprazole	0-12	signal transducer and activator of transcription 3	Mus musculus	29-34
28489606-9	2017	Our results indicated that pantoprazole treatment can decrease the levels of serum IL-6 and TNF-alpha (56.3% and 67.6%, respectively), and inhibit the activation of the JAK2/STAT3 signaling pathway.	Pantoprazole	27-39	signal transducer and activator of transcription 3	Mus musculus	174-179
28489606-11	2017	CONCLUSION: Our findings suggested that pantoprazole can alleviate cancer cachexia skeletal muscle wasting by inhibiting the inflammatory response and blocking the JAK2/STAT3 or ubiquitin proteasome pathway.	Pantoprazole	40-52	signal transducer and activator of transcription 3	Mus musculus	169-174
28594379-5	2017	In addition, we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor kappaB (NF-kappaB) pathways involved in the inflammation process of LPS-stimulated RAW 264.7 cells.	25-Anhydroalisol F	54-72	signal transducer and activator of transcription 3	Mus musculus	129-182
28594379-5	2017	In addition, we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor kappaB (NF-kappaB) pathways involved in the inflammation process of LPS-stimulated RAW 264.7 cells.	25-Anhydroalisol F	54-72	signal transducer and activator of transcription 3	Mus musculus	184-189
28594379-6	2017	The phosphorylation of ERK, JNK, p38, and STAT3, and the NF-kappaB signaling pathway, were obviously suppressed in alisol F and 25-anhydroalisol F treated cells.	alisol F	115-123	signal transducer and activator of transcription 3	Mus musculus	42-47
28594379-6	2017	The phosphorylation of ERK, JNK, p38, and STAT3, and the NF-kappaB signaling pathway, were obviously suppressed in alisol F and 25-anhydroalisol F treated cells.	25-Anhydroalisol F	128-146	signal transducer and activator of transcription 3	Mus musculus	42-47
28498414-6	2017	Nifuroxazide, an antidiarrheal agent, has been proved to directly inhibit STAT3 activation.	nifuroxazide	0-12	signal transducer and activator of transcription 3	Mus musculus	74-79
28594379-0	2017	Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-kappaB Activation In Vitro and In Vivo.	alisol F	53-61	signal transducer and activator of transcription 3	Mus musculus	117-122
28594379-0	2017	Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-kappaB Activation In Vitro and In Vivo.	25-Anhydroalisol F	66-84	signal transducer and activator of transcription 3	Mus musculus	117-122
28594379-5	2017	In addition, we investigated the role of alisol F and 25-anhydroalisol F in mediating mitogen-activated protein kinases (MAPKs), signal transducers, and activators of transcription 3 (STAT3) and nuclear factor kappaB (NF-kappaB) pathways involved in the inflammation process of LPS-stimulated RAW 264.7 cells.	alisol F	41-49	signal transducer and activator of transcription 3	Mus musculus	129-182
28217966-11	2017	Mortality was increased in interleukin-10 (IL-10)-deficient mice, and pristane treatment decreased IL-10 receptor expression in monocytes and STAT-3 phosphorylation in lung macrophages.	pristane	70-78	signal transducer and activator of transcription 3	Mus musculus	142-148
28587416-8	2017	Berberine also significantly inhibited the expression of interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha mRNA and phosphorylation of signal transducer and activator of transcription 3.	Berberine	0-9	signal transducer and activator of transcription 3	Mus musculus	146-196
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	Acetaminophen	8-19	signal transducer and activator of transcription 3	Mus musculus	244-249
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	Acetaminophen	20-33	signal transducer and activator of transcription 3	Mus musculus	244-249
28286920-6	2017	Indeed, paracetamol/acetaminophen-induced liver damage was worse after Notch blockade with DAPT in wild-type mice, which was accompanied by significantly increased ALT levels, diminished hairy and enhancer of split-1 (Hes1), and phosphorylated Stat3 and Akt but enhanced high mobility group box 1 (HMGB1), TLR4, NF-kappaB, and NLRP3 activation after APAP challenge.	dapt	91-95	signal transducer and activator of transcription 3	Mus musculus	244-249
28251448-0	2017	Effects of Ergosterol on COPD in Mice via JAK3/STAT3/NF-kappaB Pathway.	Ergosterol	11-21	signal transducer and activator of transcription 3	Mus musculus	47-52
28251448-6	2017	Furthermore, ER significantly inhibited the protein expression of JAK3/STAT3/NF-kappaB pathway in CS-induced mice.	Cesium	98-100	signal transducer and activator of transcription 3	Mus musculus	71-76
28320873-4	2017	Treatment of mice with the YAP inhibitor verteporfin (VP) inhibited activation of genes associated with senescence, SASPs, and activation of Stat3 as well as impeded the development of fibrosis.	Verteporfin	41-52	signal transducer and activator of transcription 3	Mus musculus	141-146
28320873-4	2017	Treatment of mice with the YAP inhibitor verteporfin (VP) inhibited activation of genes associated with senescence, SASPs, and activation of Stat3 as well as impeded the development of fibrosis.	Verteporfin	54-56	signal transducer and activator of transcription 3	Mus musculus	141-146
28603428-0	2017	Upregulation of miR-375 level ameliorates morphine analgesic tolerance in mouse dorsal root ganglia by inhibiting the JAK2/STAT3 pathway.	Morphine	42-50	signal transducer and activator of transcription 3	Mus musculus	123-128
28603428-7	2017	This was regulated by the miR-375 and JAK2-signal transducer and activator of transcription 3 (STAT3) pathway, and inhibition of this pathway decreased BDNF production, and thus, attenuated morphine tolerance.	Morphine	190-198	signal transducer and activator of transcription 3	Mus musculus	38-93
28603428-7	2017	This was regulated by the miR-375 and JAK2-signal transducer and activator of transcription 3 (STAT3) pathway, and inhibition of this pathway decreased BDNF production, and thus, attenuated morphine tolerance.	Morphine	190-198	signal transducer and activator of transcription 3	Mus musculus	95-100
28542400-0	2017	Intracellular Ca2+ homeostasis and JAK1/STAT3 pathway are involved in the protective effect of propofol on BV2 microglia against hypoxia-induced inflammation and apoptosis.	Propofol	95-103	signal transducer and activator of transcription 3	Mus musculus	40-45
28542400-10	2017	More importantly, these effects could be modulated by 25mumol/L propofol via maintaining intracellular Ca2+ homeostasis and via up-regulating the phosphorylation of JAK1 and STAT3 at Tyr705.	Propofol	64-72	signal transducer and activator of transcription 3	Mus musculus	174-179
28506283-9	2017	The STAT3 inhibitor S31-201 blocked inhibition of Tnfrsf11 by PRL.	NSC 74859	20-27	signal transducer and activator of transcription 3	Mus musculus	4-9
28496202-6	2017	Treatment of cultured PSC with the Jak1/2 inhibitor ruxolitinib reduced STAT3 phosphorylation, cell proliferation, and expression of alpha-smooth muscle actin (alpha-SMA), a marker of PSC activation.	ruxolitinib	52-63	signal transducer and activator of transcription 3	Mus musculus	72-77
28508871-6	2017	We show that the hepatocyte-specific deletion of Stat3, genetic ablation of Il6, treatment with a neutralizing anti-IL-6 antibody or administration of a small-molecule JAK inhibitor, abolishes FGF19-induced tumorigenesis, while the regulatory functions of FGF19 in bile acid, glucose and energy metabolism remain intact.	Bile Acids and Salts	265-274	signal transducer and activator of transcription 3	Mus musculus	49-54
28508871-6	2017	We show that the hepatocyte-specific deletion of Stat3, genetic ablation of Il6, treatment with a neutralizing anti-IL-6 antibody or administration of a small-molecule JAK inhibitor, abolishes FGF19-induced tumorigenesis, while the regulatory functions of FGF19 in bile acid, glucose and energy metabolism remain intact.	Glucose	276-283	signal transducer and activator of transcription 3	Mus musculus	49-54
28496142-6	2017	In vitro studies revealed that SC-43 promoted HSC apoptosis, increased the SHP-1 activity and inhibited phospho-STAT3.	SC-43	31-36	signal transducer and activator of transcription 3	Mus musculus	112-117
28324784-0	2017	An in vivo active 1,2,5-oxadiazole Pt(II) complex: A promising anticancer agent endowed with STAT3 inhibitory properties.	1,2,5-oxadiazole pt(ii)	18-41	signal transducer and activator of transcription 3	Mus musculus	93-98
28324784-1	2017	New Pt(II) complexes (Pt-1-3) bearing 1,2,5-oxadiazole ligands (1-3) were synthesized, characterized and evaluated for their ability to disrupt STAT3 dimerization.	Platinum	4-6	signal transducer and activator of transcription 3	Mus musculus	144-149
27715403-5	2017	Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models.	Calcitriol	0-10	signal transducer and activator of transcription 3	Mus musculus	79-84
28324784-3	2017	Its corresponding platinum complex Pt-3 exhibited an increased cytotoxicity (IC50 = 18.4 muM) and a stronger interaction with STAT3 (IC50 = 1.4 muM), leading to inhibition of its signaling pathway.	Platinum	18-26	signal transducer and activator of transcription 3	Mus musculus	126-131
27715403-5	2017	Calcitriol, the active form of vitamin D, has been shown to decrease STAT1 and STAT3 phosphorylation in cancer cell lines and autoimmune disease mouse models.	Vitamin D	31-40	signal transducer and activator of transcription 3	Mus musculus	79-84
28324784-3	2017	Its corresponding platinum complex Pt-3 exhibited an increased cytotoxicity (IC50 = 18.4 muM) and a stronger interaction with STAT3 (IC50 = 1.4 muM), leading to inhibition of its signaling pathway.	pt-3	35-39	signal transducer and activator of transcription 3	Mus musculus	126-131
28467929-6	2017	The PPARgamma agonist pioglitazone reverses PAH and inhibits the TGFbeta1-Stat3-FoxO1 axis in TGFbeta1-overexpressing mice.	Pioglitazone	22-34	signal transducer and activator of transcription 3	Mus musculus	74-79
28469076-7	2017	Topical hydrocortisone, rapamycin, or Stat3 inhibitor XVIII prevents autoantibody-induced blistering in the PV passive transfer mouse model, correlating with increased epidermal DSG3 expression and decreased phospho-S727 Stat3.	Hydrocortisone	8-22	signal transducer and activator of transcription 3	Mus musculus	221-226
28469076-7	2017	Topical hydrocortisone, rapamycin, or Stat3 inhibitor XVIII prevents autoantibody-induced blistering in the PV passive transfer mouse model, correlating with increased epidermal DSG3 expression and decreased phospho-S727 Stat3.	Sirolimus	24-33	signal transducer and activator of transcription 3	Mus musculus	221-226
29029396-0	2017	Activation of cannabinoid receptor type II by AM1241 protects adipose-derived mesenchymal stem cells from oxidative damage and enhances their therapeutic efficacy in myocardial infarction mice via Stat3 activation.	AM 1241	46-52	signal transducer and activator of transcription 3	Mus musculus	197-202
29029396-8	2017	Mechanistically, AM1241 activated signal transducers and activators of transcription 3 (Stat3) through the phosphorylation of Akt and ERK1/2.	AM 1241	17-23	signal transducer and activator of transcription 3	Mus musculus	34-86
29029396-8	2017	Mechanistically, AM1241 activated signal transducers and activators of transcription 3 (Stat3) through the phosphorylation of Akt and ERK1/2.	AM 1241	17-23	signal transducer and activator of transcription 3	Mus musculus	88-93
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	iodopravadoline	32-37	signal transducer and activator of transcription 3	Mus musculus	102-107
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	39-47	signal transducer and activator of transcription 3	Mus musculus	102-107
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	U 0126	49-54	signal transducer and activator of transcription 3	Mus musculus	102-107
29029396-9	2017	Moreover, the administration of AM630, LY294002, U0126 and AG490 (inhibitors for CB2, Akt, ERK1/2 and Stat3, respectively) could abolish the beneficial actions of AM1241.	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	59-64	signal transducer and activator of transcription 3	Mus musculus	102-107
27853831-0	2017	Role of the lipid-regulated NF-kappaB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.	1-Naphthylisothiocyanate	57-86	signal transducer and activator of transcription 3	Mus musculus	43-48
28232202-6	2017	In U266 xenografted mice, SNAC treatment decreased the activity of STAT3 and reduced the growth of human CD138 positive cells (U266 cells) in the bone marrow and also reduced their production of human IgE into the serum.	S-nitroso-N-acetylcysteine	26-30	signal transducer and activator of transcription 3	Mus musculus	67-72
28160136-5	2017	The finding showed that, accompanied with the inhibition on the level of Abeta1-42 in primary neurons and APP/PS1 transgenic mice, geniposide induced the phosphorylation of JAK2 and STAT3, regulated the expression level of alpha- and beta-secretase, and all of these could be prevented by the pre-incubation with LA.	geniposide	131-141	signal transducer and activator of transcription 3	Mus musculus	182-187
27580405-6	2017	In a co-culture model with microglia and endothelial cells under a high glucose condition, the microglia-derived IL-6 induced STAT3 activation in the retinal endothelial cells, leading to increasing endothelial permeability.	Glucose	72-79	signal transducer and activator of transcription 3	Mus musculus	126-131
28282575-6	2017	Sorafenib also interfered with ERK MAPK, p38 MAPK, and STAT3 signaling, as well as cyclin D expression, but did not affect HER-2 or AKT signaling.	Sorafenib	0-9	signal transducer and activator of transcription 3	Mus musculus	55-60
28213589-9	2017	At the molecular level, SH479 inhibited TH17 differentiation by regulating signal transducer and activator of transcription-3 (STAT3) phosphorylation, DNA binding activity, and recruitment to the Il-17a promoter in CD4+ T cells.	sh479	24-29	signal transducer and activator of transcription 3	Mus musculus	75-125
28213589-9	2017	At the molecular level, SH479 inhibited TH17 differentiation by regulating signal transducer and activator of transcription-3 (STAT3) phosphorylation, DNA binding activity, and recruitment to the Il-17a promoter in CD4+ T cells.	sh479	24-29	signal transducer and activator of transcription 3	Mus musculus	127-132