PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33799221-6	2021	Mechanistically, RA3 was able to alleviate HG-stimulated oxidative stress through the inhibition of reactive oxygen species (ROS) and lipid peroxidation as well as the reduced expression of the PKC/NF-kB cascade through decreased intracellular lipid content.	ra3	17-20	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	198-203
7895918-2	1994	An electrophoretic mobility shift assay using nuclear extracts and an oligonucleotide probe corresponding to the Ig KB binding site was employed to identify activated NF-KB.	Oligonucleotides	70-85	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	167-172
33799221-6	2021	Mechanistically, RA3 was able to alleviate HG-stimulated oxidative stress through the inhibition of reactive oxygen species (ROS) and lipid peroxidation as well as the reduced expression of the PKC/NF-kB cascade through decreased intracellular lipid content.	Mercury	43-45	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	198-203
33235440-0	2020	Casticin Improves Respiratory Dysfunction and Attenuates Oxidative Stress and Inflammation via Inhibition of NF-kB in a Chronic Obstructive Pulmonary Disease Model of Chronic Cigarette Smoke-Exposed Rats.	casticin	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	109-114
33814208-0	2021	Dapsone Ameliorates Colitis through TLR4/NF-kB Pathway in TNBS Induced Colitis Model in Rat.	Dapsone	0-7	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	41-46
33814208-12	2021	Western blot revealed that dapsone could attenuate inflammation via downregulation of toll-like receptor 4 (TLR4) and dephosphorylation of nuclear factor kB (NF-kB).	Dapsone	27-34	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	139-156
33814208-12	2021	Western blot revealed that dapsone could attenuate inflammation via downregulation of toll-like receptor 4 (TLR4) and dephosphorylation of nuclear factor kB (NF-kB).	Dapsone	27-34	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	158-163
33233503-7	2020	We demonstrated that BAY 11-7082 treatment inhibited NLRP3 inflammasome activation and NF-kB translocation, reducing inflammatory mediators.	3-(4-methylphenylsulfonyl)-2-propenenitrile	21-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	87-92
33815046-9	2021	The levels of NF-kappaB1, RelA, GAP43, SP, CGRP, TRPM8, IL-1beta, and TNF-alpha in the IVD of DDD + SIM group were significantly lower than those in DDD group (P < 0.05).	Dichlorodiphenyldichloroethane	94-97	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	26-30
33817258-0	2020	Reversine and herbal Xiang-Sha-Liu-Jun-Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-kappaB/caspase signaling pathway.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	118-122
33817258-0	2020	Reversine and herbal Xiang-Sha-Liu-Jun-Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-kappaB/caspase signaling pathway.	Thioacetamide	63-76	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	118-122
33817258-5	2020	Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1beta, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-kappaB (p65) phosphorylation and caspase 1 activation.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	76-80
33817258-6	2020	Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1beta, and MCP-1 cytokines.	2-(4-morpholinoanilino)-6-cyclohexylaminopurine	112-121	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	125-129
34718940-5	2022	METHODS AND RESULTS: In this context, we created a full-thickness excisional wound model in Wistar albino rats and, investigated NF-kappaB p65 DNA-binding activity and expression levels of RELA (p65), MMP2 and MMP9 in wound samples taken on days 0, 3, 7, and 14 from diabetic/non-diabetic rats treated with metformin and saline.	Metformin	307-316	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	189-193
34774683-15	2022	CONCLUSION: These data depict that AMEZO and kaempferol showed antihypertensive activity in LNAME induced hypertensive rats possibly mediated through improvement in NO and cGMP levels, modulation of mRNA expression of eNOS, ACE, COX-2 and NF-kB and suppression of oxidative stress related inflammatory markers, proposing a defensive role in cardiovascular diseases.	amezo	35-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	239-244
34774683-15	2022	CONCLUSION: These data depict that AMEZO and kaempferol showed antihypertensive activity in LNAME induced hypertensive rats possibly mediated through improvement in NO and cGMP levels, modulation of mRNA expression of eNOS, ACE, COX-2 and NF-kB and suppression of oxidative stress related inflammatory markers, proposing a defensive role in cardiovascular diseases.	kaempferol	45-55	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	239-244
34751495-10	2022	Conversely, quercetin pretreatment improved these renal histo-biochemical alterations (p < .05) and regulated autophagy/NF-kB pathways.	Quercetin	12-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
34599475-11	2022	ISO administration in heart tissue is regulated by gossypin with increased SOD activity, GSH amount, TNF-alpha, IL-6, IL-1beta, and NF-kB mRNA expression levels and decreased MDA amount.	Isoproterenol	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	132-137
34599475-11	2022	ISO administration in heart tissue is regulated by gossypin with increased SOD activity, GSH amount, TNF-alpha, IL-6, IL-1beta, and NF-kB mRNA expression levels and decreased MDA amount.	gossypin	51-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	132-137
34343646-14	2021	CONCLUSION: Mentionable basis was found on behalf of the anti-inflammatory and antioxidant potentials of ETM which might be correlated with its NF-kB inhibiting properties.	etm	105-108	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	144-149
34082127-9	2021	Using microarrays experiments, we also showed that several pathways related to inflammation and oxidative stress (Eicosanoid signaling, MIF-mediated innate immunity, NF-kB signaling, TNFR2 signaling, IL6 signaling, Production of nitric oxide and ROS) were down-regulated in the brain of RSV treatments rats compared to control rats.	Resveratrol	287-290	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	166-171
34597787-0	2021	Anti-inflammatory/Anti-apoptotic impact of Betulin Attenuates experimentally Induced Ulcerative Colitis; An insight into TLR4/NF-kB/caspase signalling modulation.	betulin	43-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	126-131
34597787-6	2021	Moreover, betulin dampened UC-associated colonic inflammatory load with modulation of TLR4/NF-kB axis and reduction in colonic inflammatory cytokines; TNF-alpha, IL1beta and IL-6.	betulin	10-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-96
34120280-8	2021	Finally, the mRNA transcripts of brain Keap-1, Nrf2, and NF-kB were upregulated after ACR intoxication.	Acrylamide	86-89	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
34339751-8	2021	Moreover, chrysin formulations were able to inhibit doxorubicin-induced Tol-like receptor 4 (TLR4) and p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) protein expression which in turn, reduced procaspase-1, Cysteinyl Aspartate Protease-1 (caspase-1) and Interleukin-1beta (IL-1beta) protein expression via inhibiting Nod-like receptor pyrin containing 3 (NLRP3) inflammasome.	chrysin	10-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	182-187
34504589-12	2021	GdCl3 may alleviate systemic and intestinal inflammatory responses and reduce the expression of MLCK through inhibition of the activation of NF-kB.	gdcl3	0-5	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	141-146
34339751-8	2021	Moreover, chrysin formulations were able to inhibit doxorubicin-induced Tol-like receptor 4 (TLR4) and p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) protein expression which in turn, reduced procaspase-1, Cysteinyl Aspartate Protease-1 (caspase-1) and Interleukin-1beta (IL-1beta) protein expression via inhibiting Nod-like receptor pyrin containing 3 (NLRP3) inflammasome.	Doxorubicin	52-63	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	182-187
34392152-8	2021	In summary, our study suggests that BRD4 is involved in Cd-triggered transcription of inflammatory cytokines by mediating the activation of NF-kappaB signaling pathway and increasing itself binding to acetylated NF-kappaB RelA in rat kidney, therefore, BRD4 could be a potential therapeutic target for Cd-induced renal diseases.	Cadmium	56-58	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	222-226
34630095-0	2021	Higenamine Attenuates Neuropathic Pain by Inhibition of NOX2/ROS/TRP/P38 Mitogen-Activated Protein Kinase/NF-kB Signaling Pathway.	higenamine	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	106-111
34630095-11	2021	Our research results suggested that Hig improved NP-induced oxidative stress injury, inflammation, and apoptosis, and this neuroprotective effect may be related to the NOX2/ROS/TRP/P38 MAPK/NF-kB signaling pathway.	higenamine	36-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	190-195
34603014-0	2021	Folate Reverses NF-kappaB p65/Rela/IL-6 Level Induced by Hyperhomocysteinemia in Spontaneously Hypertensive Rats.	Folic Acid	0-6	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	30-34
34603014-10	2021	Furthermore, folate inhibited the expression of IL-6 and NF-kappaB p65/Rela, reduced the levels of MDA and HHcy, but significantly increased the SOD level.	Folic Acid	13-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	71-75
34603014-12	2021	However, folate demonstrated anti-inflammatory properties and reversed the NF-kappaB p65/Rela/IL-6 level induced by HHcy in hypertensive rats.	Folic Acid	9-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-93
34392152-7	2021	Cd increased the acetylation level of RelA K310 and enhanced BRD4 binding to acetylated NF-kappaB RelA in vivo and in vitro, which were abrogated by inhibiting BRD4.	Cadmium	0-2	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	38-42
34392152-7	2021	Cd increased the acetylation level of RelA K310 and enhanced BRD4 binding to acetylated NF-kappaB RelA in vivo and in vitro, which were abrogated by inhibiting BRD4.	Cadmium	0-2	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	98-102
34392152-7	2021	Cd increased the acetylation level of RelA K310 and enhanced BRD4 binding to acetylated NF-kappaB RelA in vivo and in vitro, which were abrogated by inhibiting BRD4.	L-arabinitol	43-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	38-42
34630095-11	2021	Our research results suggested that Hig improved NP-induced oxidative stress injury, inflammation, and apoptosis, and this neuroprotective effect may be related to the NOX2/ROS/TRP/P38 MAPK/NF-kB signaling pathway.	Tryptophan	177-180	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	190-195
34466404-16	2021	On the other hand, CNP could decrease invasion and inflammatory reaction of macrophages; the mechanism was involved in inhibiting NF-kB signal pathway through the cGMP/PKG in macrophages.	Cyclic GMP	163-167	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	130-135
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Palmitic Acid	95-97	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	78-84
34167418-0	2021	The effect of N-acetyl cysteine and doxycycline on TNF-alpha-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide.	Acetylcysteine	14-31	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
34167418-0	2021	The effect of N-acetyl cysteine and doxycycline on TNF-alpha-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide.	Doxycycline	36-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
34167418-0	2021	The effect of N-acetyl cysteine and doxycycline on TNF-alpha-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide.	2-chloroethyl ethyl sulfide	157-184	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
34319254-11	2021	In addition, AL could also regulate the Nrf-2/HO-1/HMGB1/NF-kB signal pathway in the hippocampus.	albiflorin	13-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Lycopene	189-197	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	78-84
34567144-9	2021	Serum TNF-alpha, NF-kB, bilirubin, IL-6 levels, ALT, AST, ALP activities and tissue MPO activity and oxidant damage increased after the bile duct ligation was significantly decreased following SPL administration.	Spironolactone	193-196	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	17-22
34242224-0	2021	Intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis indexes of young adult rats with anterior palatal suture expansion model.	prolinedithiocarbamate	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	41-46
34242224-3	2021	In this paper, we mainly studied the effect of intraperitoneal injection of PDTC on the NF-kB signaling pathway and osteogenesis index of the anterior palatal suture expansion model in young adult rats.	prolinedithiocarbamate	76-80	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	88-93
34242224-5	2021	The results revealed that PDTC inhibited the activity of NF-kB signaling pathway and promote one morphogenetic protein 2 (BMP-2), steocalatin (OCN) expression.	prolinedithiocarbamate	26-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
34335814-6	2021	Moreover, spironolactone, a mineralocorticoid receptor (MR) blocker, suppressed cell pyroptosis through SGK-1 and NF-kB.	Spironolactone	10-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	114-119
34135893-6	2021	Reactive oxygen species (ROS)-ERK-NF-kB signaling increased the expression of MCP1 in antigen-stimulated RBL2H3 cells.	Reactive Oxygen Species	0-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	34-39
34135893-6	2021	Reactive oxygen species (ROS)-ERK-NF-kB signaling increased the expression of MCP1 in antigen-stimulated RBL2H3 cells.	Reactive Oxygen Species	25-28	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	34-39
35452635-0	2022	Suppression of PCSK9/NF-kB-dependent pathways by acetate ameliorates cardiac inflammation in a rat model of polycystic ovarian syndrome.	Acetates	49-56	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	21-26
34284543-8	2021	The western blot results showed that the phosphorylation levels of ERK, JNK, MAPK, NF-kB and Akt were up-regulated by curcumin.	Curcumin	118-126	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	83-88
34842380-6	2021	The obtained qPCR results showed a significant up regulation in the expression of Cyp3A6, HO-1, TNFalpha and NFKB genes in the liver of rats treated with aflatoxin.	Aflatoxins	154-163	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	109-113
35452635-10	2022	SIGNIFICANCE: The present results suggest that acetate protects against cardiac inflammation in a rat model of PCOS by suppression of PCSK9 and NF-kB-dependent mechanisms.	Acetates	47-54	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	144-149
35608813-17	2022	The neuroprotective effect of AGN against LPS-induced cell death is attributed by modulating NF-kB and Nrf2 signaling pathway in the striatum.	Apigenin	30-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	93-98
35320496-7	2022	Also, moreover, the excess production of IL-1beta, TNF-alpha, IRAK, and NF-kB were noticeably attenuated in all terpinen 4-ol treated rats, however, IL-17 and IL-10 were distinctly increased compared to arthritic control rats in RT-PCR.	terpinenol-4	112-125	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	72-77
35334385-5	2022	The IL-1beta, IL-8 concentration and expression increased, the endothelial cells injury which stimulated by high glucose and the concentration of dsDNA in serum increased, the expression of CXCR2, phosphor-IkappaBalpha and NF-kB increased while the expression of CSE and concentration of H2S decreased in neutrophils in the T1DM group compared to the control group.	Glucose	113-120	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	223-228
35608813-0	2022	Apigenin Attenuates Functional and Structural Alterations via Targeting NF-kB/Nrf2 Signaling Pathway in LPS-Induced Parkinsonism in Experimental Rats : Apigenin Attenuates LPS-Induced Parkinsonism in Experimental Rats.	Apigenin	152-160	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	72-77
35384464-9	2022	Conversely, the cilostazol treatment improved all these cardiac deleterious effects, inhibiting NF-kB activation and subsequently decreasing inflammatory mediators, reestablishing the antioxidant properties through Nrf2-mediated pathway, including increased SOD, GPx, and catalase expression.	Cilostazol	16-26	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	96-101
35384464-10	2022	Taken together, our results indicated that cilostazol protects hypercholesterolemia-induced cardiac damage by molecular mechanisms targeting the crosstalk between Nrf2 induction and NF-kB inhibition in the heart.	Cilostazol	43-53	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	182-187
35608322-13	2022	RESULTS: L-NAME induced liver dysfunction evidenced by liver histology, increased activities of ALT, AST, hyperlipidemia, hepatic oxidative stress and increased hepatic NF-kB expression.	NG-Nitroarginine Methyl Ester	9-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	169-174
35499270-9	2022	And paeoniflorin attenuated LPS-induced Schwann cell apoptosis by decreasing the levels of TLR4, p-NF-kB, caspase3, cleaved-caspase3, and cleaved-caspase7.	peoniflorin	4-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-104
35202911-0	2022	Type-2 diabetic rat heart: The effect of kolaviron on mTOR-1, P70S60K, PKC-alpha, NF-kB, SOD-2, NRF-2, eNOS, AKT-1, ACE, and P38 MAPK gene expression profile.	kolaviron	41-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	82-87
35454187-1	2022	Hydrogen Sulphide Treatment Prevents Renal Ischemia-Reperfusion Injury by Inhibiting the Expression of ICAM-1 and NF-kB Concentration in Normotensive and Hypertensive Rats.	Hydrogen Sulfide	0-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	114-119
35202911-7	2022	Nevertheless, kolaviron modulated the expression profile of these genes, which suggest a therapeutic effect and target for vascular dysfunction and complications in type-2 diabetes through the activation of the NRF-2/AKT-1/eNOS signaling pathway and suppression of the NF-kB/PKC signaling pathway.	kolaviron	14-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	269-274
35212850-0	2022	Nerolidol: a potential approach in rheumatoid arthritis through reduction of TNF-alpha, IL-1beta, IL-6, NF-kB, COX-2 and antioxidant effect in CFA-induced arthritic model.	nerolidol	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	104-109
35259467-0	2022	Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways.	sodium arsenite	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	125-130
35212850-10	2022	Besides that, overexpression of gene pointers like TNF-alpha, IL-1beta, IL-6, NF-kB, PGE-2 and COX-2 in CFA-treated control rats were also reversed with nerolidol.	nerolidol	153-162	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	78-83
35355181-0	2022	The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB.	kaempferol	27-37	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
35259467-13	2022	Accordingly, DG co-exposure with As3+ markedly enhances the expressions of TNF-alpha, IL-6, and NF-kB compared to DG alone.	as3+	33-37	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	96-101
35340717-5	2022	Also, NDMA significantly increased lung Bax, p53, caspase-3, TNF-alpha, IL-1beta, NFkB, and decreased Bcl-2, mdm2, cyclin D1 and Nrf-2 levels.	Dimethylnitrosamine	6-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	82-86
35042170-9	2022	Fluoxetine improved animals" behavior, increased brain monoamines, BDNF besides increased antioxidant defense mechanism of SOD, TAC contents and increased protein expression of Nrf2/HO-1 with significant decrease of AChE activity, beta-amyloid, Tau protein, MDA, TNF-alpha, IL1beta contents as well as decreased protein expression of NF-kB, TLR4, NLRP3 and caspase1.	Fluoxetine	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	334-339
35190649-10	2022	AEPAS showed a marked decrease in alloxan-induced increases in FBG, TG, LDL-c, G6P, F-1, 6-BP, MDA, IL-6, TNF-alpha, and NF-kB and increased alloxan-induced decreases in liver glycogen, hexokinase, and HDL-c.	Alloxan	34-41	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	121-126
35185572-8	2022	Moreover, isoorientin can significantly reduce oleic acid -induced oxidative damage and steatosis by regulating the PPARgamma/NF-kB p65 signal pathway.	homoorientin	10-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	126-131
35186099-7	2022	Results: Irisin reduced the levels of IL-6, IL-8, TNF-alpha, and NF-kB in serum.	irisin	9-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-70
35048778-8	2022	Furthermore, inhibition of NF-kB signaling by DHMEQ abolished LPS-induced myocardial inflammation and apoptosis.	dehydroxymethylepoxyquinomicin	46-51	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	27-32
35185572-8	2022	Moreover, isoorientin can significantly reduce oleic acid -induced oxidative damage and steatosis by regulating the PPARgamma/NF-kB p65 signal pathway.	Oleic Acid	47-57	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	126-131
34975295-0	2022	7,8-Dihydroxyflavone alleviates apoptosis and inflammation induced by retinal ischemia-reperfusion injury via activating TrkB/Akt/NF-kB signaling pathway.	6,7-dihydroxyflavone	0-20	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	130-135
35048805-12	2022	CONCLUSION: Breviscapine combined with BMSCs treatment can reduce Abeta deposition in AD rats and promote the degradation of APP and BAEC1 by activating NF-kB to promote UCHL1 expression.	breviscapine	12-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	153-158
34998360-12	2022	In conclusion, TPRG1 promoted inflammation and cell proliferation of cystitis glandularis through activation of NF-kB/COX2/PGE2 axis.	Dinoprostone	123-127	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	112-117
35164457-8	2022	Also, PTZ significantly increased MDA, GFAP, IL-6, NF-kB, caspase-3, and p53 and significantly reduced Sirt-1, TAC, and Bcl-2 in hippocampal tissues compared to the control group (p < 0.01).	Pentylenetetrazole	6-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	51-56
35075205-11	2022	These results suggest that high glucose concentrations lead to alteration of the redox regulatory capacity of Nrf2 mediated by NF-kB regulation.	Glucose	32-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	127-132
34975295-8	2022	Moreover, it was also found that astrocytes labeled by GFAP were activated in RIRI and NF-kB mediated the increased expressions of inflammatory factors and these effects were partially reversed by DHF administration.	dhf	197-200	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	87-92
33744436-0	2021	Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-kB.	1,3,5-TRIAZINE	26-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	125-130
33933884-7	2021	MEL at 40 mg/kg, in addition, reduced astrocyte hypertrophy, activated microglia, NF-kB-NLRP3-caspase-1 signaling, IL-1beta, MCP-1, and MIP-1alpha.	Melatonin	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	82-87
33991607-5	2021	The results demonstrated that CDDO-Im treatment markedly improved the depressive-like behaviors and reduced neuronal cell loss in the hippocampus, through decreasing the malondialdehyde (MDA) content (indicative of lipid peroxidation), superoxide dismutase (SOD), NF-kB activation, interleukin-6 (IL-6) and interleukin-1b (IL-1beta) in PSD rats.	1-(2-cyano-3,12-dioxooleana-1,9-dien-28-oyl) imidazole	30-37	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	264-269
33836247-0	2021	Ceftriaxone reduces waterpipe tobacco smoke withdrawal-induced anxiety in rats via modulating the expression of TNF-alpha/NFkB, Nrf2, and GLT-1.	Ceftriaxone	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	122-126
34042266-0	2021	Eriodictyol attenuates TNBS-induced ulcerative colitis through repressing TLR4/NF-kB signaling pathway in rats.	eriodictyol	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
34042266-0	2021	Eriodictyol attenuates TNBS-induced ulcerative colitis through repressing TLR4/NF-kB signaling pathway in rats.	Trinitrobenzenesulfonic Acid	23-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
34036049-9	2021	The ethanol-induced inflammation and apoptosis were also significantly decreased by reducing the increased gastric myeloperoxidase activity and the expression of NF-kB and p53.	Ethanol	4-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	162-167
34036049-11	2021	Conclusion: TPM exerted a gastro-protective effect against ethanol-induced gastric ulcers mediated by reducing the gastric ulcer index, preventing a decrease of the mucus levels, reduction in inflammation, damage to gastric histology, and a decrease in the enhanced expression of NF-kB and TPM.	Topiramate	12-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	280-285
33242925-0	2021	Protective effects of carvacrol against diabetes-induced reproductive damage in male rats: Modulation of Nrf2/HO-1 signalling pathway and inhibition of Nf-kB-mediated testicular apoptosis and inflammation.	carvacrol	22-31	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	152-157
33933169-9	2021	RESULTS: Addition of neostigmine to selective or non-selective NSAIDs (celecoxib or diclofenac) causes an increased level of analgesia of NSAIDs with rapid onset of action and short duration, while causing potentiation of the anti-inflammatory effect of neostigmine as seen in the tail clip, writhing, formalin test, Cox-1 and Cox-2 activities, serum beta-endorphin, TNF-alpha, NF-kB and HS-CRP.	Neostigmine	21-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	378-383
33933169-9	2021	RESULTS: Addition of neostigmine to selective or non-selective NSAIDs (celecoxib or diclofenac) causes an increased level of analgesia of NSAIDs with rapid onset of action and short duration, while causing potentiation of the anti-inflammatory effect of neostigmine as seen in the tail clip, writhing, formalin test, Cox-1 and Cox-2 activities, serum beta-endorphin, TNF-alpha, NF-kB and HS-CRP.	Celecoxib	71-80	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	378-383
33933169-9	2021	RESULTS: Addition of neostigmine to selective or non-selective NSAIDs (celecoxib or diclofenac) causes an increased level of analgesia of NSAIDs with rapid onset of action and short duration, while causing potentiation of the anti-inflammatory effect of neostigmine as seen in the tail clip, writhing, formalin test, Cox-1 and Cox-2 activities, serum beta-endorphin, TNF-alpha, NF-kB and HS-CRP.	Diclofenac	84-94	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	378-383
33929391-8	2021	Moreover, the introduction of ozone reversed these changes in gene expression and suppressed the activation of the TLR4/NF-kB signaling, which indicated that ozone may exert protective effects on H9c2 heart myoblasts by relieving the cardiotoxicity induced by DOX.	Ozone	30-35	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
33929391-8	2021	Moreover, the introduction of ozone reversed these changes in gene expression and suppressed the activation of the TLR4/NF-kB signaling, which indicated that ozone may exert protective effects on H9c2 heart myoblasts by relieving the cardiotoxicity induced by DOX.	Ozone	158-163	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
33929391-8	2021	Moreover, the introduction of ozone reversed these changes in gene expression and suppressed the activation of the TLR4/NF-kB signaling, which indicated that ozone may exert protective effects on H9c2 heart myoblasts by relieving the cardiotoxicity induced by DOX.	Doxorubicin	260-263	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
33247942-13	2021	In all NAC treatment groups, levels of serum IL-6, neuronal apoptosis and brain NFkB, nNOS, Caspase 3, TNF-alpha, IL-6 and IL-1beta protein levels were significantly reduced compared to NEC group.	Acetylcysteine	7-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	80-84
33247942-14	2021	The most pronounced decrease was demonstrated within the NAC-NEC-NAC group CONCLUSIONS: NAC treatment can attenuate newborn inflammatory response syndrome and decrease offspring brain neuro apoptosis and inflammation in a rat model of NEC by inhibition of NFkB, nNOS and Caspase 3 pathways.	Acetylcysteine	57-60	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	256-260
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	7-hydroxycoumarin	27-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-153
33522649-0	2021	Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways.	Cisplatin	49-58	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-153
33915267-0	2021	Everolimus inhibits PI3K/Akt/mTOR and NF-kB/IL-6 signaling and protects seizure-induced brain injury in rats.	Everolimus	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	38-43
33915267-5	2021	Therefore, this study aimed to investigate the neuroprotective effect of Everolimus on seizure-induced brain injury and its regulation of the PI3K/Akt/mTOR and NF-kB/IL-6 signaling pathway.	Everolimus	73-83	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	160-165
33915267-10	2021	CONCLUSIONS: Everolimus can decrease the PI3K/Akt/mTOR and NF-kB/IL-6 signaling pathway, reduce neuronal apoptosis and microglia activation, and attenuate seizure susceptibility and intensity, thus having a protective effect on seizure-induced brain damage.	Everolimus	13-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	59-64
33905819-0	2021	Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of Nrf2/HO-1 and mitigation of NF-kB/MAPK signaling pathways.	Thioacetamide	91-104	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	194-199
33881685-12	2021	Additionally, SN diminished lipid peroxidation and downregulated NF-kB in animals exposed to a low dose of LPS, with increased TIMP1 expression, while in animals treated with a high dose of LPS, SN increased NF-kB, MMP2, and MMP9 levels.	Tin	14-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-70
33881685-12	2021	Additionally, SN diminished lipid peroxidation and downregulated NF-kB in animals exposed to a low dose of LPS, with increased TIMP1 expression, while in animals treated with a high dose of LPS, SN increased NF-kB, MMP2, and MMP9 levels.	Tin	14-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	208-213
33881685-12	2021	Additionally, SN diminished lipid peroxidation and downregulated NF-kB in animals exposed to a low dose of LPS, with increased TIMP1 expression, while in animals treated with a high dose of LPS, SN increased NF-kB, MMP2, and MMP9 levels.	Tin	195-197	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	208-213
33854955-6	2021	Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats.	sodium arsenite	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
32964425-0	2021	Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-kB.	Triiodothyronine	27-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	119-124
33146867-9	2021	EPA and CMTI also reduced the HG+6-OHDA-induced increase in the cellular levels of nuclear factor kB (NF-KB).	Oxidopamine	33-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	83-100
33146867-9	2021	EPA and CMTI also reduced the HG+6-OHDA-induced increase in the cellular levels of nuclear factor kB (NF-KB).	Oxidopamine	33-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	102-107
33242925-9	2021	It was determined that carvacrol significantly decreased malondialdehyde levels, Bax,COX-2,Nf-kB protein expression levels, Bax/Bcl-2 ratio and significantly increased glutathione peroxidase, catalase activities, Bcl-2, Nrf2,HO-1 protein expression levels and it was determined that had a positive effect on spermatological parameters.	carvacrol	23-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-96
32730712-7	2021	RAI administration significantly elevated TNF-alpha, IL-6, NF-kb levels, and decreased IL-10 levels (p < 0.05 for all parameters) whereas TOS levels significantly increased and TAS levels were significantly decreased.	Insulin, Short-Acting	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	59-64
32730712-8	2021	However, RSV significantly diminished TNF-alpha, IL-6, IL-4, and NF-kb levels.	Resveratrol	9-12	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-70
33314684-0	2021	Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti-inflammation property and AMPK/MAPK/NF-kB inhibition.	Simvastatin	18-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	132-137
33418245-0	2021	Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-beta/MMP-9 pathways.	coenzyme Q10	0-12	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	109-114
33418245-8	2021	CoQ10 also counteracts inflammatory response mediated after radiation exposure through downregulating intestinal NF-kB expression which subsequently decreased the level of inflammatory cytokine IL-6 and the expression of COX-2.	coenzyme Q10	0-5	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	113-118
33418245-10	2021	Therefore, CoQ10 is a promising radioprotector that could prevent intestinal complications and enhance the therapeutic ratio of radiotherapy in patients with pelvic tumors through suppressing the NF-kB/TGF-beta1/MMP-9 signaling pathway.	coenzyme Q10	11-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	196-201
33511885-4	2022	Administration of myrtenal to BBN-treated rats exhibited downregulation in the expressions of COX-2, NF-kB and STAT-3 associated with suppression of inflammatory cytokines levels of TNF-alpha and IL-6 as well as biomarkers of oxidative damage (MDA & NO).	Butylhydroxybutylnitrosamine	30-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	101-106
33447032-0	2021	Topical Nano-Vesicular Spanlastics of Celecoxib: Enhanced Anti-Inflammatory Effect and Down-Regulation of TNF-alpha, NF-kB and COX-2 in Complete Freund"s Adjuvant-Induced Arthritis Model in Rats.	Celecoxib	38-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	117-122
33447032-14	2021	In the animal model of RA, the celecoxib-loaded spanlastics-containing gel significantly reduced edema circumference and significantly suppressed TNF-alpha, NF-kB and COX-2 levels compared to the niosomes-containing gel, the marketed diclofenac sodium gel, and unprocessed celecoxib-loaded gel.	Celecoxib	31-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	157-162
32356088-0	2021	Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-kB inflammatory signalling.	Isoproterenol	66-79	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	128-133
32356088-11	2021	The study indicated that pre-treatment with G. acuta protects against ISO-induced AMI, and the protective role may be related to inhibiting Gal-3/TLR4/MyD88/NF-kB inflammatory signalling.	Isoproterenol	70-73	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	157-162
33407557-13	2021	CONCLUSIONS: BBR may relieve PCOS pathology and IR values by inhibiting cell apoptosis and by regulating the expression levels of TLR4, LYN, PI3K, Akt, NF-kB, TNF-alpha, IL-1, IL-6, and caspase-3.	Berberine	13-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	152-157
33381027-7	2020	Also, the tissue levels of the pro-inflammatory mediators; IL-1beta, TNF-alpha, and NF-kB, were significantly increased in the cisplatin group.	Cisplatin	127-136	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	84-89
33336463-0	2021	Anti-inflammatory effect of amitriptyline in a rat model of acetic acid-induced colitis: the involvement of the TLR4/NF-kB signaling pathway.	Amitriptyline	28-41	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	117-122
32980348-9	2020	Vitexin improved the high glucose-induced nuclear transcription factor system by suppressing Rel A, Rel B, P50/p105, and IkappaB expression resulting in decreased cell apoptosis, further confirmed by the reduction in the percentage of Annexin-V positive cells.	Glucose	26-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	93-98
33256017-9	2020	CONCLUSIONS: Preventive treatment with AphaMax  attenuates the severity of the inflammation in DNBS colitis rats involving decrease of the NF-kB activation, reduction of iNOS and COX-2 expression, and inhibition of oxidative stress.	aphamax	39-46	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	139-144
32977152-0	2020	Sumatriptan alleviates radiation-induced oral mucositis in rats by inhibition of NF-kB and ERK activation, prevention of TNF-alpha and ROS release.	Sumatriptan	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	81-86
33238688-29	2020	The HO-1/TLR4/NF-kB signaling pathway is the main regulatory mechanism of astaxanthin to achieve anti-inflammation-based renoprotection.	astaxanthine	74-85	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	14-19
32977152-14	2020	Likewise, sumatriptan decreased the increased level of NF-kB and prevented its activation as well as ERK phosphorylation.	Sumatriptan	10-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	55-60
32977152-16	2020	CONCLUSION: Based on study results, sumatriptan mitigate radiation-induced oral mucositis by inhibiting NF-kB, ERK and limiting the release of TNF-alpha, oxidative stress factor and apoptosis.	Sumatriptan	36-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	104-109
32594336-0	2020	Bupropion Ameliorates Acetic Acid-Induced Colitis in Rat: the Involvement of the TLR4/NF-kB Signaling Pathway.	Bupropion	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	86-91
32800830-0	2020	Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-kB signaling in rats.	Hesperidin	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
32800830-0	2020	Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-kB signaling in rats.	Cadmium	28-35	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
32787472-0	2020	Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway.	Risperidone	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	86-91
32787472-0	2020	Risperidone attenuates acetic acid-induced colitis in rats through inhibition of TLR4/NF-kB signaling pathway.	Acetic Acid	23-34	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	86-91
32787472-7	2020	Furthermore, bothdexamethasone and risperidone(2, 4 and 6 mg/kg) significantly reducedacetic acid-induced expression of TLR4and pNF-kB proteins (p < 0.05, p < 0.01, P < 0.001).Conclusion The anti-inflammatory effect of risperidoneon acetic acid-induced colitis in rats may involve inhibition of TLR4 and NF-kB signaling pathway.	bothdexamethasone	13-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	129-134
32594336-7	2020	In addition, the expression of TLR4 and NF-kB was decreased after colitis induction; however, treatment with dexamethasone (2 mg/kg) and bupropion (160 mg/kg) resulted in a significant decrease in their expression.	Dexamethasone	109-122	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	40-45
32787472-7	2020	Furthermore, bothdexamethasone and risperidone(2, 4 and 6 mg/kg) significantly reducedacetic acid-induced expression of TLR4and pNF-kB proteins (p < 0.05, p < 0.01, P < 0.001).Conclusion The anti-inflammatory effect of risperidoneon acetic acid-induced colitis in rats may involve inhibition of TLR4 and NF-kB signaling pathway.	Risperidone	35-46	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	129-134
32787472-7	2020	Furthermore, bothdexamethasone and risperidone(2, 4 and 6 mg/kg) significantly reducedacetic acid-induced expression of TLR4and pNF-kB proteins (p < 0.05, p < 0.01, P < 0.001).Conclusion The anti-inflammatory effect of risperidoneon acetic acid-induced colitis in rats may involve inhibition of TLR4 and NF-kB signaling pathway.	reducedacetic acid	79-97	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	129-134
32594336-7	2020	In addition, the expression of TLR4 and NF-kB was decreased after colitis induction; however, treatment with dexamethasone (2 mg/kg) and bupropion (160 mg/kg) resulted in a significant decrease in their expression.	Bupropion	137-146	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	40-45
32594336-9	2020	In conclusion, bupropion exerts anti-inflammatory influence through suppressing the TLR4 and NF-kB expression in the rat model of acute colitis.	Bupropion	15-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	93-98
33099123-10	2020	Apocynin attenuated serum inflammatory cytokine expression and placental inflammation most likely due to downregulation of the placental TLR4/NF-kB pathway in L-NAME treated rats.	acetovanillone	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	142-147
33099123-10	2020	Apocynin attenuated serum inflammatory cytokine expression and placental inflammation most likely due to downregulation of the placental TLR4/NF-kB pathway in L-NAME treated rats.	NG-Nitroarginine Methyl Ester	159-165	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	142-147
32718261-6	2020	Moreover, treatment with PE and/or curcumin exerted a significant upregulation of Nrf2/HO-1 gene expressions along with significant downregulation of NF-kB, TGF-beta, and phospho-Smad3 protein expressions, as well as alpha-SMA and collagen-1 gene expressions.	Curcumin	35-43	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	150-155
32718261-5	2020	The results indicated that PE and/or curcumin attenuated TAA-induced liver fibrogenesis, as evidenced by significant improvement in the liver function tests (AST, ALT, ALP, and albumin), oxidative stress biomarkers (MDA, SOD, and GSH), and inflammatory biomarkers (NF-kB, TNF-alpha, IL-1beta, iNOS, TGF-beta, and MPO), compared to TAA group.	Curcumin	37-45	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	265-270
32376365-10	2020	RESULTS: AlCl3-treated rats (17 mg/kg/day) showed histopathological alteration in brain tissues together with elevated levels of Abeta, tau proteins, MDA, NF-kB and IL-6.	Aluminum Chloride	9-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	155-160
32997222-10	2020	Treatment with DOP attenuated the protein expression of TLR-4, NF-kB, cyclin B1, and Sirt-1 in the brain tissue of rats with neuronal injury.	3,5-dihydroxy-4'-methoxystilbene	15-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	63-68
32963259-3	2020	Our study uncovered that EECGL significantly ameliorates HM-induced hyperlipidemia, increased lipogenesis and metabolic disturbances (via up regulation of PPAR-alpha and PPAR-gamma), oxidative stress (via reducing the generation of reactive oxygen species and regulating the redox-homeostasis) and inflammatory response (via regulating the pro-inflammatory and anti-inflammatory factors with concomitant down regulation of NF-kB, iNOS, TNF-alpha and up regulation of eNOS).	eecgl	25-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	423-428
32963259-3	2020	Our study uncovered that EECGL significantly ameliorates HM-induced hyperlipidemia, increased lipogenesis and metabolic disturbances (via up regulation of PPAR-alpha and PPAR-gamma), oxidative stress (via reducing the generation of reactive oxygen species and regulating the redox-homeostasis) and inflammatory response (via regulating the pro-inflammatory and anti-inflammatory factors with concomitant down regulation of NF-kB, iNOS, TNF-alpha and up regulation of eNOS).	medrysone	57-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	423-428
32360572-8	2020	SIGNIFICANCE: Hyperoside attenuated pregnancy loss through regulating mTOR/S6K and TLR4/MyD88/NF-kB signaling pathways, which may provide a potential drug candidate for recurrent pregnancy loss therapy.	hyperoside	14-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-99
32565337-0	2020	Inosine, an endogenous purine nucleoside, avoids early stages of atherosclerosis development associated to eNOS activation and p38 MAPK/NF-kB inhibition in rats.	Inosine	0-7	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	136-141
32687664-7	2020	Finally, BMS345541, an inhibitor of the NF-kB signaling pathway, could reverse the effects of hyperoside on the biological functions in rBMSCs.	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	9-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	40-45
32687664-7	2020	Finally, BMS345541, an inhibitor of the NF-kB signaling pathway, could reverse the effects of hyperoside on the biological functions in rBMSCs.	hyperoside	94-104	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	40-45
32687664-8	2020	In conclusion, our results suggest that hyperoside has potential therapeutic properties against periodontitis via promotion of proliferation and osteogenic differentiation of rBMSCs via activation of the NF-kB signaling pathway.	hyperoside	40-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	204-209
32086724-9	2020	Besides, the activity of NF-kB p65 was reduced and the p53 and Bax protein levels were inhibited in these myocardial cells subjected to DOX.	Doxorubicin	136-139	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	25-30
32917219-1	2020	BACKGROUND: Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway.	Glutamic Acid	153-162	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
32917219-1	2020	BACKGROUND: Chronic hyperammonemia induces neuroinflammation in cerebellum, with glial activation and enhanced activation of the TNFR1-NF-kB-glutaminase-glutamate-GABA pathway.	gamma-Aminobutyric Acid	163-167	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
32803467-1	2020	PURPOSE: Increased nitric oxide (NO) synthesis and NF-kB activation have been shown as critical players in the pathophysiology of vincristine-induced peripheral neuropathy.	Vincristine	130-141	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	51-56
32803467-3	2020	Previous studies demonstrated that aripiprazole is capable of modulating NO synthesis and also has been reported its modulatory effect on NF-kB activity.	Aripiprazole	35-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	138-143
32803467-7	2020	Expression of nNOS and NF-kB activation were evaluated by western blotting RESULTS: Rats receiving aripiprazole during neuropathy establishment period demonstrated a normal weight gain pattern, a significantly higher mechanical withdrawal threshold, and SNCV compared to vincristine-treated group.	Aripiprazole	99-111	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	23-28
32803467-9	2020	Western blotting demonstrated a significantly reduced expression of nNOS and NF-kB activation in dorsal root ganglia of aripiprazole co-treated rats.	Aripiprazole	120-132	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	77-82
32920758-0	2020	Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.	Cadmium	72-79	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	143-148
32920758-0	2020	Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.	Fluorides	84-92	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	143-148
32920758-6	2020	Up-regulation of inflammatory genes (TNF-alpha, IL-1beta and NF-kB) and pro-apoptotic Bax as well as down-regulation of anti-apoptotic Bcl-2 were detected after co-exposure to F and Cd.	Cadmium	182-184	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
32649955-0	2020	Alpha-lipoic acid effectively attenuates ionizing radiation-mediated testicular dysfunction in rats: Crosstalk of NF-kB, TGF-beta, and PPAR-Upsilon pathways.	Thioctic Acid	0-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	114-119
32678046-10	2020	In the diabetic bladder, miR-128 can regulate the expression of NF-KB and p-JNK through CB1 and affect the level of apoptosis.	mir-128	25-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	64-69
32678046-11	2020	miR-128 regulates NF-KB/p-JNK through CB1, thus affecting the occurrence of diabetic bladder disease.	mir-128	0-7	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	18-23
32678046-12	2020	CONCLUSION: The high expression of miR-128 can down-regulate the expression of CB1, promote the activation of NF-KB and p-JNK, increase the level of apoptosis and promote the occurrence of diabetic bladder disease.	mir-128	35-42	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	110-115
32596035-11	2020	Tissue homogenate of the kidney extracted from LCZ696 and valsartan treated diabetic rats revealed a substantial reduction in the levels of inflammatory markers such as TNF-alpha, IL-1beta, IL-6, NF-kB and sufficient restoration of anti-oxidant enzyme levels (P < 0.05).	Valsartan	58-67	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	196-201
32441355-0	2020	Arthrocen, an avocado-soy unsaponifiable agent, improves acetic acid-induced colitis in rat by inhibition of NF-kB signaling pathway.	arthrocen	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	109-114
32304050-0	2020	Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.	Cadmium	35-42	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	149-154
32304050-0	2020	Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.	Fluorides	47-55	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	149-154
32304050-9	2020	On the other hand, TNF-alpha, IL-1beta, and NF-kB inflammatory genes were upregulated in the liver after combined exposure to F and Cd compared to individual treatments.	Cadmium	132-134	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	44-49
32596035-11	2020	Tissue homogenate of the kidney extracted from LCZ696 and valsartan treated diabetic rats revealed a substantial reduction in the levels of inflammatory markers such as TNF-alpha, IL-1beta, IL-6, NF-kB and sufficient restoration of anti-oxidant enzyme levels (P < 0.05).	sacubitril and valsartan sodium hydrate drug combination	47-53	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	196-201
31869757-3	2020	We aimed to evaluate the antioxidant, anti-inflammatory and antiapoptotic effects of Agomelatine (AGM) on LPS induced brain damage via NF-kB signaling.	agomelatine	85-96	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
32494142-13	2020	MiR-579-3p overexpression inhibited NF-kB activity by reducing NRIP1.	mir-579-3p	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	36-41
31677006-0	2020	Geniposide Alleviates Traumatic Brain Injury in Rats Via Anti-Inflammatory Effect and MAPK/NF-kB Inhibition.	geniposide	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-96
31729763-12	2020	Both MAPKs were upstream to p65/NF-kB inasmuch as both MAPKs" inhibitors PD98059 and SP600125 or their down-regulation by siRNA significantly blocked the TGF-beta1-induced nuclear translocation of p65/NF-kB.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	73-80	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-37
31729763-12	2020	Both MAPKs were upstream to p65/NF-kB inasmuch as both MAPKs" inhibitors PD98059 and SP600125 or their down-regulation by siRNA significantly blocked the TGF-beta1-induced nuclear translocation of p65/NF-kB.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	73-80	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	201-206
31729763-12	2020	Both MAPKs were upstream to p65/NF-kB inasmuch as both MAPKs" inhibitors PD98059 and SP600125 or their down-regulation by siRNA significantly blocked the TGF-beta1-induced nuclear translocation of p65/NF-kB.	pyrazolanthrone	85-93	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-37
32036095-10	2020	Moreover, DHLA pretreatment reversed the protein level expressions of akt, p-akt, mTOR, GR, NFkB, ERK1, Nrf2, HO-1, cleaved caspase 3 and cytochrome c. In conclusion, results showed that DHLA could attenuate Hg2+-induced cytotoxicity via limiting Hg accumulation, boosting up of antioxidant defense, and inhibition of apoptosis in cells.	dihydrolipoic acid	10-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	92-96
32597253-6	2020	Finally, expression of NF-kB and p-NF-kB was investigated by western blot.Results: Results of survival rate and levels of lungs parameters indicated therapeutic potential of combination treatment of MON and DXM.	Dexamethasone	207-210	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	23-28
32597253-6	2020	Finally, expression of NF-kB and p-NF-kB was investigated by western blot.Results: Results of survival rate and levels of lungs parameters indicated therapeutic potential of combination treatment of MON and DXM.	Dexamethasone	207-210	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	35-40
32597253-10	2020	Evidence of significant down regulation of NF-kB and phospho-NF-kB was also found with the combination treatment of MON and DXM.Conclusions: Given the advantage of therapeutic synergism activity of MON and DXM, it may be used in the prophylaxis of PQ-intoxication following clinical trials.	Dexamethasone	124-127	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	43-48
32597253-10	2020	Evidence of significant down regulation of NF-kB and phospho-NF-kB was also found with the combination treatment of MON and DXM.Conclusions: Given the advantage of therapeutic synergism activity of MON and DXM, it may be used in the prophylaxis of PQ-intoxication following clinical trials.	Dexamethasone	124-127	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
32597253-10	2020	Evidence of significant down regulation of NF-kB and phospho-NF-kB was also found with the combination treatment of MON and DXM.Conclusions: Given the advantage of therapeutic synergism activity of MON and DXM, it may be used in the prophylaxis of PQ-intoxication following clinical trials.	Dexamethasone	206-209	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	43-48
32597253-10	2020	Evidence of significant down regulation of NF-kB and phospho-NF-kB was also found with the combination treatment of MON and DXM.Conclusions: Given the advantage of therapeutic synergism activity of MON and DXM, it may be used in the prophylaxis of PQ-intoxication following clinical trials.	Dexamethasone	206-209	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
31729763-12	2020	Both MAPKs were upstream to p65/NF-kB inasmuch as both MAPKs" inhibitors PD98059 and SP600125 or their down-regulation by siRNA significantly blocked the TGF-beta1-induced nuclear translocation of p65/NF-kB.	pyrazolanthrone	85-93	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	201-206
32359381-12	2020	The levels of expression of NF-kB, ICAM-1, TNF-alpha and IL-beta in placental tissues were significantly higher in GDM group than in control group, but were significantly reduced by ferulic acid treatment (p < 0.05).	ferulic acid	182-194	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	28-33
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	119-125	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-103
31378303-4	2020	RESULTS: Our findings demonstrate that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and associated increases in H3K9me2 (histone H3 lysine 9 dimethylation) in the dorsal hippocampus and that SETD6 knockdown interferes with memory consolidation, alters gene expression patterns, and disrupts spine morphology.	Lysine	178-184	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-103
31869757-3	2020	We aimed to evaluate the antioxidant, anti-inflammatory and antiapoptotic effects of Agomelatine (AGM) on LPS induced brain damage via NF-kB signaling.	agomelatine	98-101	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
31869757-8	2020	Besides, AGM treatment blocked the phosphorylation of NF-kB biochemically and ameliorated increased the levels of hyperemia, edema and degenerative changes histopathologically.	agomelatine	9-12	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	54-59
31869757-9	2020	In conclusion, AGM enhanced SIRT-1 levels to negatively regulate the transcription and activation of p-NF-kB/p65 which caused to ameliorate inflammation, oxidative stress and apoptosis.	agomelatine	15-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	103-108
31751619-0	2020	N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-kB axis.	Acetylcysteine	0-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	128-133
31786496-5	2020	Protein expression of western blot analysis showed that co-exposure of D-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mTOR, p-mTOR, Akt, p-Akt, NF-kB, Nrf2, ERK1, GR, Bcl-x and down-regulation of death factors; p53, Bax, cytochrome c, LC3, although arsenic regulated those factors negatively.	pinitol	71-80	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	247-252
31786496-5	2020	Protein expression of western blot analysis showed that co-exposure of D-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mTOR, p-mTOR, Akt, p-Akt, NF-kB, Nrf2, ERK1, GR, Bcl-x and down-regulation of death factors; p53, Bax, cytochrome c, LC3, although arsenic regulated those factors negatively.	Arsenic	85-92	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	247-252
31786496-5	2020	Protein expression of western blot analysis showed that co-exposure of D-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mTOR, p-mTOR, Akt, p-Akt, NF-kB, Nrf2, ERK1, GR, Bcl-x and down-regulation of death factors; p53, Bax, cytochrome c, LC3, although arsenic regulated those factors negatively.	Arsenic	117-124	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	247-252
31971058-5	2020	Spinal NF-kappaB and the phosphorylation and activation status of NF-kappaB p65/RelA (p-p65) were inhibited by the intrathecal injection of the inhibitor PDTC in this model.	prolinedithiocarbamate	154-158	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	80-84
31786496-5	2020	Protein expression of western blot analysis showed that co-exposure of D-pinitol and arsenic significantly inhibited arsenic-induced autophagy which further suppressed apoptosis through up-regulation of survival factors; mTOR, p-mTOR, Akt, p-Akt, NF-kB, Nrf2, ERK1, GR, Bcl-x and down-regulation of death factors; p53, Bax, cytochrome c, LC3, although arsenic regulated those factors negatively.	Arsenic	117-124	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	247-252
31599078-10	2020	We believe that edaravone acts to reduce the expression of NF-kB p65 by clearing ROS, which causes reduced expression of GADD45A, and subsequently reduces the level of apoptosis and inflammatory response proteins, thereby reducing the symptoms of CIA.	edaravone	16-25	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	59-64
32718263-10	2020	BA also downregulated the transcription of vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta) and decreased the expression of the NF-kB pathway proteins (NF-kB-P65, IkBalpha, and IKKalpha/beta) in the TNF-alpha-stimulated RA-FLS.	betulinic acid	0-2	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	168-173
32718263-11	2020	These results indicate that BA alleviated the symptoms of CIA by inhibiting synoviocyte proliferation, modifying TNF-alpha- and NF-kB-related inflammatory pathways, and downregulating inflammatory mediators and growth factors including IL-1beta, IL-6, VEGF, and TGF-beta.	betulinic acid	28-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	128-133
31751619-0	2020	N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-kB axis.	Acetylcysteine	18-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	128-133
32344394-0	2020	Design and Development of Novel Pyrazole-Thiadiazole Derivatives as NF-kB Inhibitor and Cardioprotective Effect against Isoproterenol Induced Myocardial Infarction in Sprague-Dawley Rats.	pyrazole-thiadiazole	32-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	68-73
32344394-0	2020	Design and Development of Novel Pyrazole-Thiadiazole Derivatives as NF-kB Inhibitor and Cardioprotective Effect against Isoproterenol Induced Myocardial Infarction in Sprague-Dawley Rats.	Isoproterenol	120-133	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	68-73
32344394-1	2020	The present study was aimed to discover novel pyrazole-thiadiazole derivatives as potent NF-kB inhibitor and its cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats.	pyrazole	46-54	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-94
32344394-1	2020	The present study was aimed to discover novel pyrazole-thiadiazole derivatives as potent NF-kB inhibitor and its cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats.	Thiadiazoles	55-66	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-94
32344394-1	2020	The present study was aimed to discover novel pyrazole-thiadiazole derivatives as potent NF-kB inhibitor and its cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats.	Isoproterenol	145-158	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-94
32344394-1	2020	The present study was aimed to discover novel pyrazole-thiadiazole derivatives as potent NF-kB inhibitor and its cardioprotective effect against isoproterenol (ISO)-induced myocardial infarction (MI) in rats.	Isoproterenol	160-163	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	89-94
30903350-0	2019	Thymol reduces acetic acid-induced inflammatory response through inhibition of NF-kB signaling pathway in rat colon tissue.	Thymol	0-6	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
31859817-9	2019	Further mechanism studies demonstrated that BCA inhibited inflammatory reaction through blocking TLR4/NF-kB/NLRP3 signaling pathway.	biochanin A	44-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	102-107
30903350-0	2019	Thymol reduces acetic acid-induced inflammatory response through inhibition of NF-kB signaling pathway in rat colon tissue.	Acetic Acid	15-26	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
31256287-8	2019	Extensive vacuolization of distal tubular cells (DTCs) was found in DM1, but it was attenuated in the STZ + DHA group, in which the highest renal NF-kB expression was observed.	Streptozocin	102-105	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-151
31256287-8	2019	Extensive vacuolization of distal tubular cells (DTCs) was found in DM1, but it was attenuated in the STZ + DHA group, in which the highest renal NF-kB expression was observed.	dehydroacetic acid	108-111	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-151
31420791-0	2019	Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-kB signaling.	rhyncophylline	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	121-126
31420791-0	2019	Rhynchophylline attenuates migraine in trigeminal nucleus caudalis in nitroglycerin-induced rat model by inhibiting MAPK/NF-kB signaling.	Nitroglycerin	70-83	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	121-126
30929154-9	2019	Sumatriptan (0.3 mg/kg) decreased lipid peroxidation, CK-MB and lactate dehydrogenase levels; tumor necrosis factor concentration; and Nf-kB" protein production.	Sumatriptan	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-141
31377587-12	2019	Western blot results showed that ketamine combined with DHA can effectively inhibit the expression of NF-KB in hippocampus and PC12 cells, and increase the expression of P-CREB and BDNF.	Ketamine	33-41	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	102-107
31377587-12	2019	Western blot results showed that ketamine combined with DHA can effectively inhibit the expression of NF-KB in hippocampus and PC12 cells, and increase the expression of P-CREB and BDNF.	dehydroacetic acid	56-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	102-107
31451204-0	2019	Effect of sevoflurane treatment on microglia activation, NF-kB and MAPK activities.	Sevoflurane	10-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
31451204-10	2019	Sevoflurane treatment decreased microglia activation by suppressing NF-kB and MAPK signaling pathways.	Sevoflurane	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	68-73
30913372-8	2019	Additionally, CLA suppresses toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling activation to inhibit nuclear factor-kB (NF-kB) signaling in the kidney of fructose-fed rats.	Linoleic Acids, Conjugated	14-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	131-148
31005592-0	2019	Leonurine alleviates LPS-induced myocarditis through suppressing the NF-kB signaling pathway.	leonurine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	69-74
31005592-13	2019	Our results demonstrated that LE exerts potent cardioprotective effects against myocarditis via anti-inflammatory and antioxidative mechanisms, possibly through blocking the activation of NF-kB pathway.	leonurine	30-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	188-193
31085161-9	2019	The data from the transfection of miR-193a mimic, miR-193a inhibitor, WT1 siRNA or LV5-WT1 in cultured differentiated podocytes showed that fructose increased miR-193a to down-regulate WT1, and subsequently activated C-mip to suppress RelA, causing podocyte apoptosis.	Fructose	140-148	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	235-239
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	Curcumin	9-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	153-158
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	piperine	22-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	153-158
30796904-0	2019	Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-kB pathway.	Berberine	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	134-139
30796904-8	2019	Further research on the adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK)/nuclear factor kappaB (NF-kappaB) pathway found that BBR upregulated the activity of AMPK, while it downregulated the expression of phospho-RelA (p-p65), phospho-NF-kappa-B inhibitor alpha (p-IkappaBalpha) and cyclooxygenase (COX)-2.	Adenosine Monophosphate	52-55	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	229-233
30913372-8	2019	Additionally, CLA suppresses toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling activation to inhibit nuclear factor-kB (NF-kB) signaling in the kidney of fructose-fed rats.	Linoleic Acids, Conjugated	14-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	150-155
30913372-8	2019	Additionally, CLA suppresses toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling activation to inhibit nuclear factor-kB (NF-kB) signaling in the kidney of fructose-fed rats.	Fructose	184-192	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	131-148
30913372-8	2019	Additionally, CLA suppresses toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) signaling activation to inhibit nuclear factor-kB (NF-kB) signaling in the kidney of fructose-fed rats.	Fructose	184-192	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	150-155
30848526-8	2019	In summary, administration of baicalin reduces the levels of pro-inflammatory cytokines, possibly through regulation of SIRT1-NF-kB pathway.	baicalin	30-38	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	126-131
30790645-2	2019	This hormone possess neuroprotective properties against glutamate-excitotoxicity through the activation of NF-kB, suggesting it could exert an antioxidant action.	Glutamic Acid	56-65	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	107-112
30288996-10	2019	Pharmacologic inhibition of Nf-kb signaling pathway by PDTC could significantly reduce the expression levels of p53 and the size of HO, and the reduction was most significant in the 0.6mg dosage group.	pyrrolidine dithiocarbamic acid	55-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	28-33
30288996-12	2019	Inhibition of Nf-kb signaling pathway by PDTC could significantly reduce HO formation, and the most effective concentration was 6 mg/ml for local injection.	pyrrolidine dithiocarbamic acid	41-45	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	14-19
30252871-2	2018	The aims of this study were 1) to assess the therapeutic effect of a 2-week treatment with the GC dexamethasone on hepatic damage in bile duct-ligated rats; 2) to investigate its effect on the activation of the nuclear receptors (NRs) pregnane X receptor (PXR), constitutive androstane receptor (CAR) and GC receptor (GR), and NF-kB, as well as on oxidative stress and bile acid (BA) hepatic composition.	Dexamethasone	98-111	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	327-332
30423027-11	2019	Cyclooxygenase-2 and RelA gene expression were significantly lower in ethanol-treated rats (P &lt; 0.05), indicating possible anti-inflammatory effects.	Ethanol	70-77	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	21-25
30240796-0	2018	Resveratrol down-regulates endothelin type B receptors in vascular smooth muscle cells via Sirt1/ERK1/2/NF-kB signaling pathways.	Resveratrol	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	104-109
30243070-9	2018	In addition, LIS augmented the inhibitory effect of SIL on NFkB pathway at lower dose level.	Lisinopril	13-16	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	59-63
30243070-10	2018	We concluded that LIS, via targeting NFkB pathway, increases anti-oxidant capacity of liver tissue and exhibits anti-inflammatory, anti-fibrotic and anti-angiogenic activity and augments sensitivity to SIL.	Lisinopril	18-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	37-41
29577638-10	2018	Inhibition of NF-kB signaling using p65 inhibitor pyrrolidine dithiocarbamate significantly prevented the increases of the CXCR4 expression.	pyrrolidine dithiocarbamic acid	50-77	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	14-19
30423027-4	2019	These effects were accompanied by decreased expression of Hmgcr, Srebp-2, Cox-2 and RelA, indicating downregulation of genes involved in cholesterol synthesis and inflammation.	Cholesterol	137-148	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	84-88
29969314-0	2018	Formoterol treatment prevents the effects of endotoxin on muscle TNF/NF-kB, Akt/mTOR, and proteolytic pathways in a rat model.	Formoterol Fumarate	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	69-74
29687464-8	2018	MTX-injected rats down-regulated mRNA expression of GST, SOD, steroidogenesis associated genes, IFN-gamma, Bcl2 and NFKB.	Methotrexate	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	116-120
30099050-4	2018	The results show intrahippocampal injection of OUA 10 nM to activate the Wnt/beta-Catenin signaling pathway and to increase CREB/BDNF and NFKB levels.	Ouabain	47-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	138-142
30029882-11	2018	Moreover, AMPs decreased Bax/Bcl-2 ratios followed by reduction the caspase-3 activity; and further repressed the phosphorylated NF-kB p65.	Adenylyl sulfate	10-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	129-134
29218112-7	2017	Consistently, Triptolide also prevented TGF-beta-induced signaling activation of MAPK p38, NFkB (p65) and calcineurin/NFATC3, which are known to be downstream mediators of podocyte injury.	triptolide	14-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-95
30042813-0	2018	The role of PPAR-gamma and NFKB genes expression in muscle to improve hyperglycemia in STZ-induced diabetic rat following magnesium sulfate administration.	Streptozocin	87-90	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	27-31
30042813-0	2018	The role of PPAR-gamma and NFKB genes expression in muscle to improve hyperglycemia in STZ-induced diabetic rat following magnesium sulfate administration.	Magnesium Sulfate	122-139	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	27-31
30042813-1	2018	The present study was designed to investigate the possible role of magnesium (Mg2+) on activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) and inhibition of nuclear factor-KB (NFKB p65) in muscle to increase glucose transporter 4 (GLUT4) gene expression.	Magnesium	67-76	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	204-208
30042813-11	2018	According to our findings it seems that suppressing NFKB (p65) protein synthesis and increases in PPAR-gamma gene and protein expression could help Mg2+ administration to decreases blood glucose levels.	magnesium ion	148-152	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-56
30042813-11	2018	According to our findings it seems that suppressing NFKB (p65) protein synthesis and increases in PPAR-gamma gene and protein expression could help Mg2+ administration to decreases blood glucose levels.	Glucose	187-194	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-56
29067571-0	2018	Foeniculum vulgare essential oil ameliorates acetic acid-induced colitis in rats through the inhibition of NF-kB pathway.	Oils, Volatile	19-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	107-112
29067571-0	2018	Foeniculum vulgare essential oil ameliorates acetic acid-induced colitis in rats through the inhibition of NF-kB pathway.	Acetic Acid	45-56	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	107-112
29067571-1	2018	AIM: The aim of the present study is to investigate the protective effects of Foeniculum vulgare essential oil on intestinal inflammation through the inhibition of NF-kB pathway in acetic acid-induced rat colitis.	Oils, Volatile	97-110	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	164-169
29067571-1	2018	AIM: The aim of the present study is to investigate the protective effects of Foeniculum vulgare essential oil on intestinal inflammation through the inhibition of NF-kB pathway in acetic acid-induced rat colitis.	Acetic Acid	181-192	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	164-169
29067571-9	2018	Furthermore, they inhibited acetic acid-induced expression of p-NF-kB p65 protein (p &lt; 0.05, p &lt; 0.001).	Acetic Acid	28-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	64-69
29067571-10	2018	CONCLUSION: It is proposed that the anti-inflammatory activity of F. vulgare essential oil on acetic acid-induced colitis in rats may involve the inhibition of NF-kB pathway.	essential	77-86	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	160-165
29067571-10	2018	CONCLUSION: It is proposed that the anti-inflammatory activity of F. vulgare essential oil on acetic acid-induced colitis in rats may involve the inhibition of NF-kB pathway.	Acetic Acid	94-105	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	160-165
29094308-0	2018	Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.	Rutin	26-31	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
29094308-0	2018	Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.	nimesulide	52-62	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
28949404-9	2018	These results suggest that Syk/IkB-alpha/NF-kB pathway activation contributes to hypotension and inflammation caused by the production of vasodilator and proinflammatory mediators in the zymosan-induced non-septic shock model.	Zymosan	187-194	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	41-46
30497068-10	2018	In addition, we treated caerulein- and TLC-S-induced AR42J cells with the Rela inhibitor helenalin and found that the expression of Rela, Traf3 and Ptgs2 decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference.	Ceruletide	24-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	74-78
30497068-10	2018	In addition, we treated caerulein- and TLC-S-induced AR42J cells with the Rela inhibitor helenalin and found that the expression of Rela, Traf3 and Ptgs2 decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference.	Ceruletide	24-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	132-136
30497068-10	2018	In addition, we treated caerulein- and TLC-S-induced AR42J cells with the Rela inhibitor helenalin and found that the expression of Rela, Traf3 and Ptgs2 decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference.	helenalin	89-98	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	74-78
30497068-10	2018	In addition, we treated caerulein- and TLC-S-induced AR42J cells with the Rela inhibitor helenalin and found that the expression of Rela, Traf3 and Ptgs2 decreased compared with the NC, while the expression of miR-155-5p did not show any significant difference.	helenalin	89-98	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	132-136
32186057-11	2018	QSG inhibited the activity of the signaling pathway, reduced the activity of NF-kB and inflammatory effect, and the transdifferentiation in the renal tubular epithelial cells.	(2R,3R)-N-[(1-{(3S,3aR,6S,6aR)-6-[4-({[(2R,3R)-2,3-dihydroxy-4-oxo-4-{[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]amino}butanoyl]amino}methyl)-1H-1,2,3-triazol-1-yl]hexahydrofuro[3,2-b]furan-3-yl}-1H-1,2,3-triazol-4-yl)methyl]-2,3-dihydroxy-N'-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]butanediamide (non-preferred name)	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	77-82
28949404-0	2018	The role of Syk/IkB-alpha/NF-kB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock.	2-(7-(3,4-dimethoxyphenyl)imidazo(1,2-c)pyrimidin-5-ylamino)nicotinamide	77-88	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	26-31
28382926-6	2018	Accordingly, phosphorylation of p65/RelA, IkappaB-alpha, and inhibitor of NF-kappaB kinase-beta was markedly increased by aldosterone.	Aldosterone	122-133	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	36-40
30404965-8	2018	Hyperforin treatments significantly increase the AChE and reduced the superoxide dismutase, glutathione, MDA, protein carbonyl, glutathione peroxdiase, catalase, NF-kB and IL-1beta at dose dependent manner.	hyperforin	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	162-167
28939345-7	2017	However prophylactic treatment of GA diminished oxidative stress markers, TNF-alpha, NFkB expression and enhanced anti-oxidant status, down regulated apoptosis, recovered histopatholgical alterations in small intestine.	18alpha-glycyrrhetinic acid	34-36	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	85-89
28899730-10	2017	Treatment with EGCG was effective in decreasing the nuclear translocation of subunit p65 (RelA) of the NF-kappaB dimer, and therefore canonical NF-kappaB pathway attenuation.	epigallocatechin gallate	15-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	90-94
27876536-16	2017	Our results showed a protective effect of 1alpha,25(OH)2D3 and metformin on liver in diabetic rats as indicated by an improvement of the level of the liver enzymes, decreased apoptosis and increased proliferation and this was confirmed histologically, with modulating NFkB and PPAR-alpha.	25(oh)2d3	49-58	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	268-272
27876536-16	2017	Our results showed a protective effect of 1alpha,25(OH)2D3 and metformin on liver in diabetic rats as indicated by an improvement of the level of the liver enzymes, decreased apoptosis and increased proliferation and this was confirmed histologically, with modulating NFkB and PPAR-alpha.	Metformin	63-72	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	268-272
28627596-8	2017	Curcumin was demonstrated to inhibit the IL-1beta-induced activation of NF-kappaB by suppressing IkappaBalpha phosphorylation and p65/RelA nuclear translocation.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	134-138
27888584-4	2017	Here, we studied the effects of piceatannol, a potent NF-kB inhibitor, on various oxidative stress markers and NF-kB dependent diabetic renoinflammatory cascades in rat induced by alloxan (ALX).	3,3',4,5'-tetrahydroxystilbene	32-43	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	54-59
28591668-0	2017	The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen improve ANP levels and decrease nuclear translocation of NF-kB in estrogen-deficient rats.	Raloxifene Hydrochloride	51-61	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	133-138
28591668-0	2017	The selective estrogen receptor modulators (SERMs) raloxifene and tamoxifen improve ANP levels and decrease nuclear translocation of NF-kB in estrogen-deficient rats.	Tamoxifen	66-75	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	133-138
28551619-6	2017	5-chloro-N-(2-chloro-4-(trifluoromethyl) phenyl)-2-hydroxybenzamide and 5-chloro-2-hydroxy-N-(4-hydroxyphenyl)benzamide inhibited both HL-60 cell proliferation and NFkB.	5-chloro-n-(2-chloro-4-(trifluoromethyl) phenyl)-2-hydroxybenzamide	0-67	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	164-168
28551619-6	2017	5-chloro-N-(2-chloro-4-(trifluoromethyl) phenyl)-2-hydroxybenzamide and 5-chloro-2-hydroxy-N-(4-hydroxyphenyl)benzamide inhibited both HL-60 cell proliferation and NFkB.	AKOS005874635	72-119	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	164-168
28706608-0	2017	The Effects of Melilotus officinalis Extract on Expression of Daxx, Nfkb and Vegf Genes in the Streptozotocin-Induced Rat Model of Sporadic Alzheimer"s Disease.	Streptozocin	95-109	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	68-72
27888584-10	2017	Moreover, piceatannol-treated groups showed marked inhibition of renal pro-inflammatory cytokines and NF-kB p65/p50 binding to DNA.	3,3',4,5'-tetrahydroxystilbene	10-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	102-107
27701051-7	2016	TiO2- intoxicated rats elicited a significant up-regulation in hepatic TLR-2, TLR-4, NF-kB/p65, CYP1B1 and CYP2B1 with pulmonary MMP-9, TIMP-1, TGF-beta1, collagen-1alpha, fibronectin mRNA.	titanium dioxide	0-4	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	85-90
26666666-9	2016	Finally, our data emphasize that superiority of Candesartan as compared to Perindopril is due to better activation of AT2R which results in PP2A activation, IkappaBalpha stabilization, and suppression of NFkB and STAT3 inflammatory signaling.	candesartan	48-59	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	204-208
27847206-0	2016	The sirt1/NF-kB signaling pathway is involved in regulation of endothelin type B receptors mediated by homocysteine in vascular smooth muscle cells.	Homocysteine	103-115	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	10-15
27619517-0	2016	An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells.	Cyclic AMP	82-86	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	66-71
27619517-5	2016	Pretreatment of TECs for 4h with ADM significantly reduced lipopolysaccharide (LPS)-induced release of IL-6 (P&lt;0.001) and expression of the p65 subunit of NF-kB, while doubled the expression of IkBalpha (P&lt;0.001), the physiological inhibitor of NF-kB nuclear translocation.	4h	25-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	158-163
27619517-5	2016	Pretreatment of TECs for 4h with ADM significantly reduced lipopolysaccharide (LPS)-induced release of IL-6 (P&lt;0.001) and expression of the p65 subunit of NF-kB, while doubled the expression of IkBalpha (P&lt;0.001), the physiological inhibitor of NF-kB nuclear translocation.	4h	25-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	251-256
27351326-0	2016	Selective Nuclear Factor Kappa b (NFkB) Inhibitor, Pyrrolidium Dithiocarbamate Prevents, Long-Term Histologic Damage in Ischemia-Reperfusion Injuries after Delayed Testicular Torsion.	pyrrolidium dithiocarbamate	51-78	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	10-32
27780234-10	2016	NFkB is known as a downstream pathway of Fas related apoptosis, we found Fas ligand, caspase-8 levels elevate after shock, and can be reduced by resuscitation.	ammonium ferrous sulfate	41-44	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	0-4
27324156-7	2016	In addition, carvacrol treatment suppressed the ischemia/reperfusion-induced increase in the protein expression of nuclear NF-kB p65.	carvacrol	13-22	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	123-128
27324156-8	2016	In conclusion, we have shown that carvacrol inhibits the inflammatory response via inhibition of the NF-kB signaling pathway in a rat model of focal cerebral ischemia.	carvacrol	34-43	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	101-106
27198138-8	2016	Groups III and IV (Ovx +17beta-estradiol and Ovx + bortezomib) showed decreased NF-kB/p65 and caspase-3 expression compared with the Ovx group (p &lt; 0.05).	Estradiol	24-40	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	80-85
27198138-8	2016	Groups III and IV (Ovx +17beta-estradiol and Ovx + bortezomib) showed decreased NF-kB/p65 and caspase-3 expression compared with the Ovx group (p &lt; 0.05).	Bortezomib	51-61	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	80-85
27664319-7	2016	Thus, the NF-kB signaling pathway can be activated after Arsenic trioxide treatment.	Arsenic Trioxide	57-73	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	10-15
27664319-8	2016	Besides, Akt blocker LY294002 also obviously attenuated NF-kB activation and transnuclear induced by Arsenic trioxide.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	21-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	56-61
27664319-9	2016	In concert with these results, we highlighted that the secretion of pro-inflammatory cytokine and NF-kB activation induced by Arsenic trioxide can be mediated by elevation of p-Akt in HAPI microglia cells.	Arsenic Trioxide	126-142	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	98-103
27067226-0	2016	Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFkB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats.	ushba	7-12	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	111-115
27067226-5	2016	Here, we observed that MU administration (100-300 microg/ml) significantly inhibited the expression and phosphorylation of NFkB-p65 protein similar to that of the Bay 11-7082 (NFkB inhibitor) in NFkB signaling pathway and suppressed the protein expression of ERK1/2 and JNK1/2 in MAPKs signaling pathway in AIA-FLS.	3-(4-methylphenylsulfonyl)-2-propenenitrile	163-174	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	176-180
27067226-5	2016	Here, we observed that MU administration (100-300 microg/ml) significantly inhibited the expression and phosphorylation of NFkB-p65 protein similar to that of the Bay 11-7082 (NFkB inhibitor) in NFkB signaling pathway and suppressed the protein expression of ERK1/2 and JNK1/2 in MAPKs signaling pathway in AIA-FLS.	3-(4-methylphenylsulfonyl)-2-propenenitrile	163-174	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	176-180
27351326-0	2016	Selective Nuclear Factor Kappa b (NFkB) Inhibitor, Pyrrolidium Dithiocarbamate Prevents, Long-Term Histologic Damage in Ischemia-Reperfusion Injuries after Delayed Testicular Torsion.	pyrrolidium dithiocarbamate	51-78	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	34-38
27351326-3	2016	In our study we aimed to determine the efficacy of the selective NFKB inhibitor, pyrrolidium dithiocarbamate (PDTC), on long-term histological damage in testicular IR injuries.	pyrrolidium dithiocarbamate	81-108	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-69
27351326-3	2016	In our study we aimed to determine the efficacy of the selective NFKB inhibitor, pyrrolidium dithiocarbamate (PDTC), on long-term histological damage in testicular IR injuries.	prolinedithiocarbamate	110-114	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-69
27351326-20	2016	It is possible to prevent reperfusion injuries using selective the NFKB inhibitor.&amp;nbsp.	Adenosine Monophosphate	83-86	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	67-71
27351326-20	2016	It is possible to prevent reperfusion injuries using selective the NFKB inhibitor.&amp;nbsp.	nbsp	87-91	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	67-71
27010086-11	2016	Furthermore, the expressions of NF-kappaB p65/RelA and phospho-NF-kappaB p65/RelA (Ser536) were suppressed after 2,5-HD exposure and restored by NAC pretreatment.	Acetylcysteine	145-148	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	46-50
27109029-4	2016	Using retinal microvessels, the site of histopathology associated with diabetic retinopathy, from streptozotocin-induced diabetic rats, we investigated the binding of the nuclear transcriptional factor-kB (NF-kB) at Rac1 promoter.	Streptozocin	98-112	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	206-211
27038922-0	2016	Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway.	Atorvastatin	0-12	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	78-83
27038922-1	2016	AIM: The aim of the present study is to explore whether atorvastatin improves intestinal inflammation through the inhibition of the TLR4/NFkB signaling pathway in TNBS-induced rat colitis.	Atorvastatin	56-68	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	137-141
27038922-10	2016	CONCLUSIONS: It is suggested that the anti-inflammatory effect of atorvastatin on TNBS-induced rat colitis may involve the inhibition of the TLR4/NFkB signaling pathway.	Atorvastatin	66-78	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-150
27038922-10	2016	CONCLUSIONS: It is suggested that the anti-inflammatory effect of atorvastatin on TNBS-induced rat colitis may involve the inhibition of the TLR4/NFkB signaling pathway.	Trinitrobenzenesulfonic Acid	82-86	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	146-150
27010086-11	2016	Furthermore, the expressions of NF-kappaB p65/RelA and phospho-NF-kappaB p65/RelA (Ser536) were suppressed after 2,5-HD exposure and restored by NAC pretreatment.	Acetylcysteine	145-148	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	77-81
27177152-0	2016	D-TRP(8)-gammaMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFalpha/NF-KB Signalling Pathway.	D-Tryptophan	0-5	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	98-103
27177152-0	2016	D-TRP(8)-gammaMSH Prevents the Effects of Endotoxin in Rat Skeletal Muscle Cells through TNFalpha/NF-KB Signalling Pathway.	(8)-gammamsh	5-17	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	98-103
27066320-9	2016	d-Trp(8)-gammaMSH treatment also prevented arthritis-induced NF-kB(p65) phosphorylation and tumour necrosis factor-alpha mRNA increase in the gastrocnemius.	D-Tryptophan	0-5	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	61-66
27066320-14	2016	CONCLUSION: These data suggest that d-Trp(8)-gammaMSH administration prevents the effect of arthritis on corticosterone and insulin-like growth factor-I serum levels and decreases muscle wasting, by down-regulating atrogenes and autophagy through modifying the NF-kB(p65)/tumour necrosis factor-alpha signalling transduction pathway.	D-Tryptophan	36-41	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	261-266
26298192-0	2015	Resveratrol ameliorates cardiac oxidative stress in diabetes through deacetylation of NFkB-p65 and histone 3.	Resveratrol	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	86-90
26823945-3	2016	The aim of this study was to evaluate whether BQ123, an endothelin-A receptor antagonist, influences the level of TNF-alpha, IL-6, SOD-1, HO-1, Nrf2 mRNA, and NF-kappaB subunit RelA/p65 mRNA in the femoral muscle obtained from endotoxemic rats.	cyclo(Trp-Asp-Pro-Val-Leu)	46-51	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	177-181
26823945-6	2016	Administration of BQ123 prior to LPS challenge resulted in a significant reduction in RelA/p65 mRNA, TNF-alpha, and IL-6 levels, as well as markedly elevated concentrations of SOD-1, HO-1, and Nrf2 mRNA.	cyclo(Trp-Asp-Pro-Val-Leu)	18-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	86-90
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Resveratrol	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-53
26298192-7	2015	Resveratrol activates SIRT-1, which deacetylates NFkB-p65 at lysine 310 and histone 3 (H3) at lysine 9 position.	Lysine	61-67	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-53
26298192-9	2015	In vitro analysis also revealed that SIRT-1 activation by resveratrol is associated with decreased NFkB-p65 activity and NOX transcription.	Resveratrol	58-69	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	99-103
26298192-11	2015	Overall, our data demonstrated that SIRT-1 activation by resveratrol leads to deacetylation of both NFkB-p65 and H3, thereby attenuating cardiac oxidative stress and complications in diabetes.	Resveratrol	57-68	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	100-104
26032259-8	2015	KEY FINDINGS: Testosterone supplements reduced the superoxide-induced apoptotic/necrotic death, stimulated NF-kappaB (RelA) expression, activated Akt activity, and inhibited Caspase-3 expression in the cardiac myocytes.	Testosterone	14-26	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	118-122
26032259-11	2015	SIGNIFICANCE: This study demonstrates that exogenous testosterone supplementation protects cardiac myocytes from superoxide injury via AR mediation and dependent on normally functional canonical NF-kappaB (RelA/p50) signalling pathways.	Testosterone	53-65	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	206-210
25837301-8	2015	All supplements elevated the phosphorylation of FOXO3A above SED at 20 min post exercise, but only the SUS supplements significantly reduced the phosphorylation of AMPK and NF-kB p65.	alanylglutamine	103-106	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	173-178
25748490-0	2015	Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved.	geranylgeranylacetone	0-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	106-111
26007330-7	2015	In addition, after BMSCs and GTPs administration, the results of Western blot and enzyme-linked immunosorbent assay (ELISA) revealed a significant decrease in protein expression level and the activation of nuclear factor-kB (NF-kB) p65.	gtps	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	206-223
26007330-7	2015	In addition, after BMSCs and GTPs administration, the results of Western blot and enzyme-linked immunosorbent assay (ELISA) revealed a significant decrease in protein expression level and the activation of nuclear factor-kB (NF-kB) p65.	gtps	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	225-230
25929726-11	2015	Based on these findings, it was concluded that the administration of cholecalciferol markedly attenuated the development of ISO-induced cardiac hypertrophy likely through downregulation of TNF-alpha /NF-kb/p65 signaling pathways.	Cholecalciferol	69-84	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	200-205
24873902-0	2014	Tamoxifen reduces infiltration of inflammatory cells, apoptosis and inhibits IKK/NF-kB pathway after spinal cord injury in rats.	Tamoxifen	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	81-86
25887435-12	2015	CONCLUSIONS: Our study demonstrated that U50,488H may have therapeutic effects on diabetic vascular dysfunction by improving endothelial dysfunction and attenuating chronic inflammation, which may be dependent on phosphorylation of eNOS and downstream inhibition of NF-kB.	488h	45-49	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	266-271
25551197-11	2014	The involvement of the inflammatory transcription factor NF-kappaB in the OUA effect was indicated by its prevention of LPS-induced nuclear translocation of the NF-kappaB subunit, RELA (p65), as well as the decreased cytosol levels of the NF-kappaB inhibitor, IKB, in the hippocampus.	Ouabain	74-77	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	180-184
25158313-9	2014	STZ treatment caused enhanced translocation of p65 NF-kB, triggered over expression of TNF-alpha, IL-1beta, COX-2, oxidative/nitrosative stress and caspase activation (p &lt; 0.05) in astrocytes.	Streptozocin	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	51-56
24873902-1	2014	In this study, neuroprotective effect of tamoxifen has been explored in spinal cord injury (SCI) in rats by examining factors influencing IKK/NF-kB pathway in SCI in rats.	Tamoxifen	41-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	142-147
24873902-4	2014	The effect of tamoxifen (5 mg/kg) on various factors responsible for activation of IKK/NF-kB signaling pathway including NF-kB p65, phosphorylated I-kBalpha was studied through Western blotting as well as densitometry.	Tamoxifen	14-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	87-92
24873902-6	2014	A comparison of three groups of rats showed that administration of tamoxifen significantly reduced the expression of NF-kB p65 and phosphorylated I-kBalpha (P &lt; 0.05) compared to control.	Tamoxifen	67-76	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	117-122
24685439-8	2014	Similarly, administration of DORA-12 on days 3 and 4 post CFA injection in the TMJ effectively inhibited the prolonged stimulated expression of protein kinase A, NFkB, and Iba1 in the STN on day 5 post injection.	dual orexin receptor antagonist 12	29-36	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	162-166
25184316-5	2014	Melatonin (100 nM) transiently (15 min) inhibited the nuclear translocation of both NF-kappaB dimers (p50/p50, p50/RelA) and, after 60 min, increased the activation of p50/RelA.	Melatonin	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-119
25184316-5	2014	Melatonin (100 nM) transiently (15 min) inhibited the nuclear translocation of both NF-kappaB dimers (p50/p50, p50/RelA) and, after 60 min, increased the activation of p50/RelA.	Melatonin	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	172-176
25184316-6	2014	Melatonin-induced p50/RelA activity in naive cells resulted in the transcription of inducible nitric oxide synthase (iNOS) and the production of NO.	Melatonin	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	22-26
25184316-7	2014	Otherwise, in cultures treated with LPS, melatonin blocked the LPS-induced activation of p50/RelA and the reduction in p50/p50 levels and inhibited iNOS expression and NO synthesis.	Melatonin	41-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	93-97
24432369-0	2013	Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-kB signaling pathway in isoproterenol-induced myocardial hypertrophy.	astragaloside	0-13	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	70-75
24796753-5	2014	Fructose-fed diabetic rats showed cardiac hypertrophy, increased NFkB activity and increased oxidative stress.	Fructose	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	65-69
24757683-7	2014	Effect of Sal B on expression of NF-kB p65 and IkB alpha was studied and OD values of densitometry of western blots were taken.	sal b	10-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	33-38
24432369-0	2013	Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-kB signaling pathway in isoproterenol-induced myocardial hypertrophy.	Isoproterenol	97-110	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	70-75
23543448-2	2013	To explore the in vitro and in vivo expression of Phospho-p38, Phospho-Akt and NF-kB in HSCs treated with H2S.	Hydrogen Sulfide	106-109	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
23561047-11	2013	Increased expression of JNK and NFKB was suppressed following metformin treatment.	Metformin	62-71	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-36
23566817-0	2013	Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2.	Permethrin	11-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	73-78
23566817-7	2013	Moreover the impairment of NF-kB and Nrf-2, important for the balance between pro- and anti-inflammatory systems, confirms that the neonatal permethrin treatment can influence genes involved with the onset of brain-ageing processes.	Permethrin	141-151	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	27-32
22913737-8	2013	U0126 and PD169316 activated Nrf2 and suppressed NF-kB pathways, 7 days after Abeta injection.	U 0126	0-5	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-54
22913737-8	2013	U0126 and PD169316 activated Nrf2 and suppressed NF-kB pathways, 7 days after Abeta injection.	2-(4-nitrophenyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazole	10-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-54
22089858-7	2012	Exposure of RPAECs to [Fe(2+)] resulted in: (i) an increase in intracellular iron as detected by the iron sensitive fluorophore, PhenGreen; (ii) depletion of cell glutathione; and (iii) nuclear translocation of stress-response transcriptional factors Nrf2 and NFkB (p65).	ammonium ferrous sulfate	23-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	260-264
22627105-0	2012	Nifedipine inhibits hypoxia induced transvascular leakage through down regulation of NFkB.	Nifedipine	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	85-89
22627105-3	2012	Prophylactic administration of nifedipine significantly reduced the transvascular leakage, oxidative stress, inhibited the up regulation of NFkB in lungs of rats compared to control.	Nifedipine	31-41	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	140-144
22627105-5	2012	These results indicate that, nifedipine has an inhibitory effect on initial leaking and showed reduction in progression of inflammation through down regulation of NFkB activity in lungs of rats under hypoxia.	Nifedipine	29-39	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	163-167
22326584-6	2012	In addition, we found that imipramine suppressed TNFalpha-induced phosphorylation of inhibitor of kappaBalpha (IkappaBalpha) and p65/RelA nuclear factor-kappaB (NF-kappaB), as well as the nuclear translocation of p65/RelA in primary cultured astrocytes.	Imipramine	27-37	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	133-137
22326584-6	2012	In addition, we found that imipramine suppressed TNFalpha-induced phosphorylation of inhibitor of kappaBalpha (IkappaBalpha) and p65/RelA nuclear factor-kappaB (NF-kappaB), as well as the nuclear translocation of p65/RelA in primary cultured astrocytes.	Imipramine	27-37	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	217-221
23428596-9	2013	Significant changes were also revealed for proliferation and migration rates, ROS level, as well as SOD, NADPH oxidase, ERK1/2 phosphorylation and NF-kB transcriptional activity in cell cultures exposed to highest dose of resveratrol.	Resveratrol	222-233	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	147-152
22476978-5	2012	Selenium supplementation restored the streptozotocin-induced alterations in the activities of antioxidant enzymes, decreased the serum glucose level, glycated hemoglobin content as well as the levels of lipid peroxidation products, and downregulated the expressions of both NFkB and RAGE.	Selenium	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	274-278
22476978-5	2012	Selenium supplementation restored the streptozotocin-induced alterations in the activities of antioxidant enzymes, decreased the serum glucose level, glycated hemoglobin content as well as the levels of lipid peroxidation products, and downregulated the expressions of both NFkB and RAGE.	Streptozocin	38-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	274-278
23559285-10	2012	CONCLUSIONS: Increased expression of TLR4 following a session of acute exercise may contribute to the activation of the NF-kB signaling route, promoting the synthesis of nitric oxide, which could influence negatively the cardiac response to high intensity physical exercise.	Nitric Oxide	170-182	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-125
22664789-11	2012	Furthermore, the use of NAC significantly reduced the expression of NFkB normally observed in RAM exposed to CSE.	Acetylcysteine	24-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	68-72
22562515-10	2012	Moreover, metformin prevented the expression of Cox-2, iNOS, and activation of NF-kB in the HNPECs and decreased the levels of NO and PGE2 in cell culture media.	Metformin	10-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	79-84
22024253-3	2012	AIM: The purpose of the present study was to investigate the effect of GSNO in ameliorating SCI-induced amenorrhea through affecting the expression of CX43, NFkB, and ERbeta protein.	S-Nitrosoglutathione	71-75	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	157-161
22093918-4	2012	Moreover, APAP induced renal damage by inducing apoptotic death and inflammation in renal tubular cells, manifested by an increase in the expression of caspase-3, caspase-9, NFkB, iNOS, Kim-1 and decrease in Bcl-2 expression.	Acetaminophen	10-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	174-178
22024253-15	2012	Following SCI, NFkB expression was increased in the ovarian follicles and the expression was reduced with GSNO administration.	S-Nitrosoglutathione	106-110	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	15-19
19876598-0	2011	Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2.	astaxanthine	0-11	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	185-189
22496598-5	2012	In contrast, bortezomib-treated rats showed a decreased number of peritoneal adhesions, decreased values of ubiquitin and the 20S proteasome, NFkB, IL-6, TNF-alpha, and increased levels of IkB-beta in the adhered peritoneal tissue.	Bortezomib	13-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	142-146
21487414-8	2011	These results provide evidence that the P2Y(1)R expressed in cortical astrocytes may help regulate the cytokine/chemokine response after tMCAO/reperfusion through a p-RelA-mediated NF-kappaB pathway.	tmcao	137-142	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	167-171
21556775-8	2012	Subsequent induction of the AP response in DR rats by turpentine administration elicited a normal, almost 2-fold increase in the serum haptoglobin level that was accompanied by HRE-binding of C/EBPbeta, STAT3/5b and NF-kB p65/p50, and the establishment of interaction between STAT3 and NF-kappaB p65.	Turpentine	54-64	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	216-221
21543116-6	2011	AOS acted on key molecules in apoptotic cell death pathway and reduced p53, p38, c-June NH2-terminal kinase phosphorylations, inhibited NFkB, and enhanced Nrf2 activation.	D-(+)-ALLOSE	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	136-140
21550382-0	2011	ReLA/P65-serine 536 nuclear factor-kappa B phosphorylation is related to vulnerability to status epilepticus in the rat hippocampus.	Serine	9-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	0-4
19876598-10	2011	In conclusion, astaxanthin exhibits anti-inflammatory and anti-cancer effects by inducing apoptosis in DMH-induced rat colon carcinogenesis by modulating the expressions of NFkB, COX-2, MMPs-2/9, Akt and ERK-2.	astaxanthine	15-26	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	173-177
21169355-0	2011	Andrographolide enhances nuclear factor-kappaB subunit p65 Ser536 dephosphorylation through activation of protein phosphatase 2A in vascular smooth muscle cells.	andrographolide	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	25-58
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	18-23
22039465-14	2011	Additionally, wounding induced rapid NF-kB(Ser536) phosphorylation, which was inhibited by AG1478, but not by Ly294002.	RTKI cpd	91-97	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	37-42
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-37
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	51-56
21625550-13	2011	Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB.	Lycopene	39-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	55-60
20826536-7	2010	PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter.	Prostaglandins F	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	22-26
21121367-6	2010	SWCNT induced nuclear NF-kB/P65 translocation can be inhibited by N-acetylcysteine, indicating elevated ICAM-1 and VCAM-1 expression is mediated by oxidative stress in RAECs, and may play important inflammatory roles in SWCNT-induced vascular endothelium damage.	Acetylcysteine	66-82	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	22-27
20826536-0	2010	Prostaglandin F2alpha (PGF2alpha) stimulates PTGS2 expression and PGF2alpha synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats.	Dinoprost	0-21	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20826536-7	2010	PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter.	Prostaglandins F	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	216-220
20826536-0	2010	Prostaglandin F2alpha (PGF2alpha) stimulates PTGS2 expression and PGF2alpha synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats.	Dinoprost	23-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20826536-0	2010	Prostaglandin F2alpha (PGF2alpha) stimulates PTGS2 expression and PGF2alpha synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats.	Dinoprost	66-75	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20826536-7	2010	PGF(2alpha) increased NFKB p65 protein expression in the nucleus of luteal cells 30 min after PGF(2alpha) injection, and electrophoretic mobility shift assay revealed that PGF(2alpha) increased binding activities of NFKB to the NFKB consensus sequence of the Ptgs2 gene promoter.	Prostaglandins F	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	216-220
20826536-8	2010	Simultaneous administration of both superoxide dismutase and catalase to scavenge reactive oxygen species (ROS) inhibited the increases of nuclear NFKB p65 protein expression, lipid peroxide levels, and Ptgs2 mRNA expression induced by PGF(2alpha).	Reactive Oxygen Species	82-105	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	147-151
20826536-0	2010	Prostaglandin F2alpha (PGF2alpha) stimulates PTGS2 expression and PGF2alpha synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats.	Reactive Oxygen Species	114-137	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20826536-8	2010	Simultaneous administration of both superoxide dismutase and catalase to scavenge reactive oxygen species (ROS) inhibited the increases of nuclear NFKB p65 protein expression, lipid peroxide levels, and Ptgs2 mRNA expression induced by PGF(2alpha).	Reactive Oxygen Species	107-110	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	147-151
20826536-9	2010	In conclusion, PGF(2alpha) stimulates Ptgs2 mRNA expression and PGF(2alpha) synthesis through NFKB activation via ROS in the corpus luteum of pseudopregnant rats.	Prostaglandins F	15-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20826536-9	2010	In conclusion, PGF(2alpha) stimulates Ptgs2 mRNA expression and PGF(2alpha) synthesis through NFKB activation via ROS in the corpus luteum of pseudopregnant rats.	Reactive Oxygen Species	114-117	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	94-98
20096333-11	2010	GW3965-induced neuroprotection was associated with a significant reduction in nuclear translocation of NF-kB p65 subunit and a decrease in the hippocampal expression of NF-kB target gene, COX-2.	GW 3965	0-6	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	103-108
20854249-7	2010	IL-1beta-induced brain endothelial expression of ICAM-1 and VCAM-1 was inhibited (80-88 %) by the proteasome inhibitor MG132 or the antioxidant caffeic acid phenethyl ester (CAPE), effects suggested to be NF-kB-dependent.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	119-124	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	205-210
20854249-7	2010	IL-1beta-induced brain endothelial expression of ICAM-1 and VCAM-1 was inhibited (80-88 %) by the proteasome inhibitor MG132 or the antioxidant caffeic acid phenethyl ester (CAPE), effects suggested to be NF-kB-dependent.	caffeic acid phenethyl ester	144-172	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	205-210
20586888-2	2010	Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production, while tumor necrosis factor (TNF) leads to inhibition of Aa-nat transcription and the production of N-acetylserotonin in cultured glands.	Corticosterone	0-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	31-35
20586888-2	2010	Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production, while tumor necrosis factor (TNF) leads to inhibition of Aa-nat transcription and the production of N-acetylserotonin in cultured glands.	Melatonin	65-74	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	31-35
20096333-11	2010	GW3965-induced neuroprotection was associated with a significant reduction in nuclear translocation of NF-kB p65 subunit and a decrease in the hippocampal expression of NF-kB target gene, COX-2.	GW 3965	0-6	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	169-174
19162042-0	2009	Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway.	Tocotrienols	39-50	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	67-71
19279034-0	2009	Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.	Curcumin	21-29	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-142
19279034-0	2009	Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.	Cisplatin	33-42	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	120-142
18989778-4	2009	Simultaneous exposure to TC (5 mM) with EtOH (5%) increased EtOH-induced NF-kappaB activation, opposing EtOH-induced decrease in cell membrane integrity and in cell viability as shown by decreasing RelA expression with siRNA technique.	Taurocholic Acid	25-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	198-202
18989778-4	2009	Simultaneous exposure to TC (5 mM) with EtOH (5%) increased EtOH-induced NF-kappaB activation, opposing EtOH-induced decrease in cell membrane integrity and in cell viability as shown by decreasing RelA expression with siRNA technique.	Ethanol	40-44	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	198-202
19002562-1	2009	Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects through inhibition of NFkB.	Curcumin	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	110-114
19002562-1	2009	Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects through inhibition of NFkB.	Curcumin	34-42	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	110-114
19002562-10	2009	Increases in the levels of TLR-4, MyD88, and NFkB proteins in inflamed tissue were also suppressed significantly by curcumin treatment.	Curcumin	116-124	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	45-49
17920532-11	2007	Sinomenine attenuated ROS production in a dose-dependent fashion and reduced the nuclear translocation of NF-kB p65 in AGEs-activated retinal microglia in culture.	sinomenine	0-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	106-111
19839830-8	2009	PJ was found to have inhibitory effects on renal tubular cell injury and oxidative stress caused by oxalate crystals by reducing ROS, iNOS, p38-MAPK, and NF-kB expression.	Oxalates	100-107	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	154-159
18641050-8	2008	Interestingly, pretreatment of animals with curcumin (NFkB blocker) attenuated hypoxia-induced vascular leakage in lungs with concomitant reduction of NFkB levels.	Curcumin	44-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	54-58
18641050-8	2008	Interestingly, pretreatment of animals with curcumin (NFkB blocker) attenuated hypoxia-induced vascular leakage in lungs with concomitant reduction of NFkB levels.	Curcumin	44-52	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	151-155
18273560-9	2008	Diethyldithiocarbamic acid (DDCA) was employed as NFkB inhibitor.	Ditiocarb	0-26	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	50-54
18273560-9	2008	Diethyldithiocarbamic acid (DDCA) was employed as NFkB inhibitor.	Ditiocarb	28-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	50-54
18404532-0	2008	The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.	S-Adenosylmethionine	37-60	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	17-22
18404532-0	2008	The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.	Acetylcysteine	62-78	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	17-22
18404532-0	2008	The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis.	Quercetin	83-92	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	17-22
18404532-7	2008	NAC decreased IKK and IkB-a phosphorylation, and Rel-A/p65 and NF-kB binding, though the last two were affected with less intensity compared to the NF-kB inhibitor.	Acetylcysteine	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	49-54
18404532-7	2008	NAC decreased IKK and IkB-a phosphorylation, and Rel-A/p65 and NF-kB binding, though the last two were affected with less intensity compared to the NF-kB inhibitor.	Acetylcysteine	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	148-153
18404532-8	2008	Quercetin decreased Rel-A/p65, without modifying upstream signalling.	Quercetin	0-9	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	20-25
17650800-4	2007	RESULTS: The PPARgamma expression decreased gradually with increasing of HSC activation, which was up-regulated by curcumin (P &lt; 0.01); curcumin inhibited the expression of aSMA, the production of collagen type I, and the nuclear expression of activated RelA (P &lt; 0.01), and elevated the activity of MMP2 and MMP9 significantly (P &lt; 0.01).	Curcumin	139-147	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	257-261
18330247-0	2007	[Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats].	puerarin	12-20	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	38-59
17650800-0	2007	[Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal].	Curcumin	11-19	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	91-95
16960103-6	2006	We find instead that Ang II stimulation rapidly induces RelA phosphorylation at serine residue 536, a critical regulatory site in its transactivating domain.	Serine	80-86	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	56-60
12139490-5	2002	DOX-induced NF-kappaB activation is both dose- and time-dependent, as demonstrated using electrophoretic mobility-shift assay and luciferase and p65 (Rel A) nuclear-translocation assays.	Doxorubicin	0-3	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	150-155
16023763-8	2005	Finally, celecoxib inhibited the translocation of Rel A/p65 to the nucleus with significant effect on stability of the repressor IkappaB-alpha.	Celecoxib	9-18	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	50-55
15545056-15	2004	Neutrophils from alcohol-drinking rats exhibited suppressed apoptosis, augmented RelA-p50 activation, and suppressed p50-p50 activation.	Alcohols	17-24	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	81-85
15545056-17	2004	An alcohol-induced upregulation of RelA-p50 activation and downregulation of p50-p50 activation may be causally related to the alcohol-induced inflammation dysregulation.	Alcohols	3-10	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	35-39
11099482-4	2001	Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.	Flurbiprofen	123-137	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	105-110
11955956-8	2002	However, the level of NF-kappaB/Rel A in nucleus was decreased by treatment of BAPTA-AM.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	79-87	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-37
12140289-6	2002	Adenoviral delivery of dn IKK beta or treatment with wortmannin inhibited B. vulgatus-induced endogenous RelA Ser-536 and GST-p65TAD (Ser-529/Ser-536) phosphorylation as well as NF-kappa B transcriptional activity in IEC-6 cells, suggesting a critical role of IKK beta and phosphatidylinositol 3-kinase/Akt in bacteria-induced RelA phosphorylation and NF-kappa B activation.	Wortmannin	53-63	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	105-109
12140289-6	2002	Adenoviral delivery of dn IKK beta or treatment with wortmannin inhibited B. vulgatus-induced endogenous RelA Ser-536 and GST-p65TAD (Ser-529/Ser-536) phosphorylation as well as NF-kappa B transcriptional activity in IEC-6 cells, suggesting a critical role of IKK beta and phosphatidylinositol 3-kinase/Akt in bacteria-induced RelA phosphorylation and NF-kappa B activation.	Wortmannin	53-63	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	327-331
12140289-6	2002	Adenoviral delivery of dn IKK beta or treatment with wortmannin inhibited B. vulgatus-induced endogenous RelA Ser-536 and GST-p65TAD (Ser-529/Ser-536) phosphorylation as well as NF-kappa B transcriptional activity in IEC-6 cells, suggesting a critical role of IKK beta and phosphatidylinositol 3-kinase/Akt in bacteria-induced RelA phosphorylation and NF-kappa B activation.	Serine	110-113	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	105-109
11099482-4	2001	Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.	Flurbiprofen	123-137	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	163-168
11099482-4	2001	Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.	Flurbiprofen	123-137	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	163-168
11099482-4	2001	Different criteria suggest that the observed effects are mediated at least in part through inhibition of NF-kB activation: R-flurbiprofen inhibited i) LPS-induced NF-kB DNA binding activity in RAW 264.7 macrophages, ii) translocation of the p65 subunit of NF-kB into the nucleus of these cells, and iii) zymosan-induced NF-kB-dependent gene transcription in the inflamed paw and spinal cord of rats.	Flurbiprofen	123-137	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	163-168
11099482-7	2001	Because R-flurbiprofen does not cause gastrointestinal mucosal damage or other side effects associated with long-term NSAID or glucocorticoid use, it might be a useful drug in inflammatory or other diseases in which increased or constitutive NF-kB and AP-1 activation are involved in the pathophysiological processes.	Flurbiprofen	8-22	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	242-247
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	24-32	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
10686520-3	2000	Caffeic acid phenethyl ester (CAPE) is a compound that modulates nuclear binding of the NF-kappaB p65 subunit (RelA).	caffeic acid phenethyl ester	0-28	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	111-115
10686520-3	2000	Caffeic acid phenethyl ester (CAPE) is a compound that modulates nuclear binding of the NF-kappaB p65 subunit (RelA).	caffeic acid phenethyl ester	30-34	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	111-115
9332715-1	1997	The oxidative stress responsive transcription factor nuclear factor-kappa B (NF-kappa B) consists of a p50 (50 kDa) and p65/RelA (65 kDa) component and can be activated in vitro by TNF alpha, IL1 beta, hydrogen peroxide and oxygen radicals.	Hydrogen Peroxide	202-219	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	124-128
9332715-1	1997	The oxidative stress responsive transcription factor nuclear factor-kappa B (NF-kappa B) consists of a p50 (50 kDa) and p65/RelA (65 kDa) component and can be activated in vitro by TNF alpha, IL1 beta, hydrogen peroxide and oxygen radicals.	Reactive Oxygen Species	224-239	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	124-128
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	0-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-57
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	0-27	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	52-57
10841980-4	2000	Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-kB activation, markedly inhibited the in vivo activation of NF-kB in the spinal cord of EAE rats and attenuated the clinical symptoms of EAE.	pyrrolidine dithiocarbamic acid	29-33	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	115-120
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	38-44	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	dbd	81-84	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Arginine	86-89	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
9261164-6	1997	Mutation of a conserved arginine or a lysine in the second zinc finger of the GR DBD (Arg-488 or Lys-490 in the rat GR) abolished the ability of GR to inhibit RelA activity.	Lysine	97-100	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	159-163
8825185-21	1996	NF-kappa B, which consists of the p50 and p65/Rel A polypeptides, was increased in hepatic nuclear extracts at 2 and 24 hr after CCI4 administration, with a concomitant decrease in the p50 polypeptide.	cci4	129-133	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	46-51
8721671-0	1996	Induction of NF-kB-like transcription factors in brain areas susceptible to kainate toxicity.	Kainic Acid	76-83	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	13-18