PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
6305188-11	1983	The patient"s enzyme migrated approximately half-way between the AK 1 and AK 2 position on starch-gel electrophoresis.	Starch	91-97	adenylate kinase 2	Homo sapiens	74-78
4044570-2	1985	Two species of adenylate kinase isozymes (ATP:AMP phosphotransferase, EC 2.7.4.3) from human Duchenne dystrophic serum were separated by Blue Sepharose CL-6B affinity column chromatography.	sepharose CL 6B	142-157	adenylate kinase 2	Homo sapiens	42-68
6308059-10	1983	The minute amount of residual activity in erythrocytes could represent a small amount of the AK2 isozyme, which has not been thought to be present in erythrocytes, or the activity of erythrocyte guanylate kinase with AMP substituting as substrate for GMP.	guanosine 5'-monophosphorothioate	251-254	adenylate kinase 2	Homo sapiens	93-96
33560378-4	2021	Adenylate kinase 2 (AK2) is a mitochondrial kinase involved in adenine nucleotide homeostasis recently reported as essential in normal T-cell development, as defective AK2 signaling pathway results in a severe combined immunodeficiency with a complete absence of T-cell differentiation.	Adenine Nucleotides	63-81	adenylate kinase 2	Homo sapiens	0-18
202953-1	1977	The effect of binding diadenosine pentaphosphate (Ap(5)A) to adenylate kinase (ATP:AMP phosphotransferase; EC 2.7.4.3) has been investigated by (31)P nuclear magnetic resonance.	P(1),P(5)-di(adenosine-5'-)pentaphosphate	22-48	adenylate kinase 2	Homo sapiens	79-105
33571905-3	2021	In the adult, conditional organ-specific ablation of AK2 precipitated abrupt heart failure with Krebs cycle and glycolytic metabolite buildup, suggesting a vital contribution to energy demanding cardiac performance.	krebs	96-101	adenylate kinase 2	Homo sapiens	53-56
33560378-9	2021	Finally, T-ALL exposure to a BCL-2 inhibitor (ABT-199 [venetoclax]) significantly enhances the cytotoxic effects of AK2 depletion.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	46-49	adenylate kinase 2	Homo sapiens	116-119
33560378-4	2021	Adenylate kinase 2 (AK2) is a mitochondrial kinase involved in adenine nucleotide homeostasis recently reported as essential in normal T-cell development, as defective AK2 signaling pathway results in a severe combined immunodeficiency with a complete absence of T-cell differentiation.	Adenine Nucleotides	63-81	adenylate kinase 2	Homo sapiens	20-23
33560378-4	2021	Adenylate kinase 2 (AK2) is a mitochondrial kinase involved in adenine nucleotide homeostasis recently reported as essential in normal T-cell development, as defective AK2 signaling pathway results in a severe combined immunodeficiency with a complete absence of T-cell differentiation.	Adenine Nucleotides	63-81	adenylate kinase 2	Homo sapiens	168-171
33560378-8	2021	Mechanistically, AK2 depletion results in mitochondrial dysfunction marked by early mitochondrial depolarization and reactive oxygen species production, together with the depletion of antiapoptotic molecules (BCL-2 and BCL-XL).	Reactive Oxygen Species	117-140	adenylate kinase 2	Homo sapiens	17-20
31247120-7	2019	Furthermore, we applied a CRISPR/Cas9-mediated methylation modifiable cell model and demonstrated that four CpGs in or near the gene region of AK2, SLC8A2, and PSTPIP2 affected the cellular response to rifampicin treatment.	Rifampin	202-212	adenylate kinase 2	Homo sapiens	143-146
33179852-7	2021	By using single amino-acid resolution screening in haploid ES cells, we report a singular critical pathway required for remdesivir toxicity, namely Adenylate Kinase 2.	remdesivir	120-130	adenylate kinase 2	Homo sapiens	148-166
32509571-5	2020	Adenylate kinase 2 (AK2) isoform, localized in intermembrane and intra-cristae space, is vital for mitochondria nucleotide exchange and ATP export.	Adenosine Triphosphate	136-139	adenylate kinase 2	Homo sapiens	0-18
32509571-5	2020	Adenylate kinase 2 (AK2) isoform, localized in intermembrane and intra-cristae space, is vital for mitochondria nucleotide exchange and ATP export.	Adenosine Triphosphate	136-139	adenylate kinase 2	Homo sapiens	20-23
32796067-16	2020	New studies reveal that Akt1 and Ak2, but not Akt3, impaired GR- and dexamethasone-mediated transactivation of the BoHV-1 immediate early transcription unit 1 and HSV-1 ICP0 promoters.	Dexamethasone	69-82	adenylate kinase 2	Homo sapiens	33-36
32815200-5	2020	We show that AK2 is a substrate of the mitochondrial disulfide relay, thus lacking an N-terminal mitochondrial targeting sequence and undergoing comparatively slow import.	Disulfides	53-62	adenylate kinase 2	Homo sapiens	13-16
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	0-18
30354009-7	2019	Our results elucidate the importance of three hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H), and one positive ionic charge (P) toward inhibition of the Ak2.	Hydrogen	46-54	adenylate kinase 2	Homo sapiens	190-193
30354009-7	2019	Our results elucidate the importance of three hydrogen bond acceptors (A), one hydrogen bond donor (D), one hydrophobic group (H), and one positive ionic charge (P) toward inhibition of the Ak2.	Hydrogen	79-87	adenylate kinase 2	Homo sapiens	190-193
29455571-4	2018	We previously demonstrated that adenylate kinase 2, pyruvate kinase, muscle and pyruvate kinase, liver and red blood cell phosphorylate TFV in peripheral blood mononuclear cells (PBMC).	Tenofovir	136-139	adenylate kinase 2	Homo sapiens	32-50
29641561-6	2018	Interestingly, we found that purified AK2 had the ability to phosphorylate tenofovir-monophosphate to tenofovir-diphosphate in addition to phosphorylating tenofovir to tenofovir-monophosphate.	FT-0674852	168-191	adenylate kinase 2	Homo sapiens	38-41
29641561-7	2018	Further, four of the six AK2 variants predicted to result in a loss or decrease of enzyme function exhibited a >=30% decrease in activity towards tenofovir in our in vitro assays.	Tenofovir	149-158	adenylate kinase 2	Homo sapiens	25-28
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	20-23
29641561-8	2018	Of note, an AK2 K28R variant resulted in a 72% and 81% decrease in the formation of tenofovir-monophosphate and tenofovir-diphosphate, respectively.	FT-0674852	84-107	adenylate kinase 2	Homo sapiens	12-15
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	FT-0674852	88-111	adenylate kinase 2	Homo sapiens	0-18
29641561-8	2018	Of note, an AK2 K28R variant resulted in a 72% and 81% decrease in the formation of tenofovir-monophosphate and tenofovir-diphosphate, respectively.	tenofovir diphosphate	112-133	adenylate kinase 2	Homo sapiens	12-15
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	FT-0674852	88-111	adenylate kinase 2	Homo sapiens	20-23
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	FT-0674852	271-294	adenylate kinase 2	Homo sapiens	0-18
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	FT-0674852	271-294	adenylate kinase 2	Homo sapiens	20-23
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	tenofovir diphosphate	327-348	adenylate kinase 2	Homo sapiens	0-18
29641561-2	2018	Adenylate kinase 2 (AK2) has been previously demonstrated to phosphorylate tenofovir to tenofovir-monophosphate, while creatine kinase, muscle (CKM), pyruvate kinase, muscle (PKM) and pyruvate kinase, liver and red blood cell (PKLR) each have been found to phosphorylate tenofovir-monophosphate to the pharmacologically active tenofovir-diphosphate.	tenofovir diphosphate	327-348	adenylate kinase 2	Homo sapiens	20-23
29641561-5	2018	To functionally test these predictions, AK2 and AK2 variants were expressed in and purified from E. coli, followed by investigation of their activities towards tenofovir.	Tenofovir	160-169	adenylate kinase 2	Homo sapiens	40-43
29641561-5	2018	To functionally test these predictions, AK2 and AK2 variants were expressed in and purified from E. coli, followed by investigation of their activities towards tenofovir.	Tenofovir	160-169	adenylate kinase 2	Homo sapiens	48-51
29641561-6	2018	Interestingly, we found that purified AK2 had the ability to phosphorylate tenofovir-monophosphate to tenofovir-diphosphate in addition to phosphorylating tenofovir to tenofovir-monophosphate.	FT-0674852	75-98	adenylate kinase 2	Homo sapiens	38-41
29641561-6	2018	Interestingly, we found that purified AK2 had the ability to phosphorylate tenofovir-monophosphate to tenofovir-diphosphate in addition to phosphorylating tenofovir to tenofovir-monophosphate.	tenofovir diphosphate	102-123	adenylate kinase 2	Homo sapiens	38-41
29641561-6	2018	Interestingly, we found that purified AK2 had the ability to phosphorylate tenofovir-monophosphate to tenofovir-diphosphate in addition to phosphorylating tenofovir to tenofovir-monophosphate.	Tenofovir	75-84	adenylate kinase 2	Homo sapiens	38-41
24548998-1	2014	Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein.	Adenine Nucleotides	41-59	adenylate kinase 2	Homo sapiens	0-18
29462620-6	2018	Thus, AK2 has a stage-specific role in maintaining the ATP supply to the nucleus during hematopoietic differentiation, which affects the transcriptional profiles necessary for controlling the fate of multipotential HAPCs.	Adenosine Triphosphate	55-58	adenylate kinase 2	Homo sapiens	6-9
26150473-6	2015	AK2-deficient iPSCs recapitulated the characteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP ratio, indicative of an energy-depleted adenine nucleotide profile.	Adenosine Monophosphate	135-138	adenylate kinase 2	Homo sapiens	0-3
26150473-6	2015	AK2-deficient iPSCs recapitulated the characteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP ratio, indicative of an energy-depleted adenine nucleotide profile.	Adenosine Diphosphate	139-142	adenylate kinase 2	Homo sapiens	0-3
26150473-6	2015	AK2-deficient iPSCs recapitulated the characteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP ratio, indicative of an energy-depleted adenine nucleotide profile.	Adenine Nucleotides	183-201	adenylate kinase 2	Homo sapiens	0-3
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	diphenyl-1-picrylhydrazyl	231-256	adenylate kinase 2	Homo sapiens	126-129
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	1,1-diphenyl-2-picrylhydrazyl	258-262	adenylate kinase 2	Homo sapiens	126-129
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	Hydrogen Peroxide	382-386	adenylate kinase 2	Homo sapiens	126-129
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	Curcumin	391-399	adenylate kinase 2	Homo sapiens	126-129
25577709-4	2015	In this context, aiming at further exploring the mechanisms of action of our newly synthesized antioxidant compounds (AK1 and AK2) in a skeletal muscle experimental setting, we initially investigated their scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and subsequently assessed their effect on the viability of C2 skeletal myoblasts in the presence of two pro-oxidants: H2O2 and curcumin (MTT assay).	monooxyethylene trimethylolpropane tristearate	401-404	adenylate kinase 2	Homo sapiens	126-129
25577709-5	2015	Interestingly, while both compounds reversed the detrimental effect of H2O2, only AK2 was cytoprotective in curcumin-treated C2 cells.	Curcumin	108-116	adenylate kinase 2	Homo sapiens	82-85
25577709-7	2015	In correlation with the aforementioned results, only AK2 blocked the curcumin-induced activation of JNKs pathway.	Curcumin	69-77	adenylate kinase 2	Homo sapiens	53-56
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Organophosphonates	4-15	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Organophosphonates	140-152	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	adefovir	153-187	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	adefovir	189-193	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	adefovir	195-203	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	209-248	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	250-254	adenylate kinase 2	Homo sapiens	94-97
25091927-4	2014	The phosphonate was shown to be a moderate but selective substrate of the mitochondrial human AK2, better than well-known antiviral acyclic phosphonates 9-(2-phosphonomethoxyethyl)adenine (PMEA, Adefovir) and (R)-9-(2-phosphonomethoxypropyl)adenine (PMPA, Tenofovir).	Tenofovir	256-265	adenylate kinase 2	Homo sapiens	94-97
24666435-7	2014	We also demonstrated that siRNA knockdown of AK2 constrained the proliferation of UM1 and UM2 cells but similarly led to an increased uptake of glucose/glutamine and production of lactate by the UM1 or UM2 cells survived from siRNA silencing of AK2.	Glucose	144-151	adenylate kinase 2	Homo sapiens	45-48
24666435-7	2014	We also demonstrated that siRNA knockdown of AK2 constrained the proliferation of UM1 and UM2 cells but similarly led to an increased uptake of glucose/glutamine and production of lactate by the UM1 or UM2 cells survived from siRNA silencing of AK2.	Glutamine	152-161	adenylate kinase 2	Homo sapiens	45-48
24666435-7	2014	We also demonstrated that siRNA knockdown of AK2 constrained the proliferation of UM1 and UM2 cells but similarly led to an increased uptake of glucose/glutamine and production of lactate by the UM1 or UM2 cells survived from siRNA silencing of AK2.	Lactic Acid	180-187	adenylate kinase 2	Homo sapiens	45-48
26270350-3	2015	AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate.	Adenine Nucleotides	47-66	adenylate kinase 2	Homo sapiens	0-3
26270350-3	2015	AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate.	Adenosine Diphosphate	68-71	adenylate kinase 2	Homo sapiens	0-3
26270350-3	2015	AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate.	Adenosine Triphosphate	73-76	adenylate kinase 2	Homo sapiens	0-3
26270350-3	2015	AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate.	Adenosine Monophosphate	81-84	adenylate kinase 2	Homo sapiens	0-3
26270350-3	2015	AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate.	Phosphates	128-137	adenylate kinase 2	Homo sapiens	0-3
26400880-4	2015	Among these kinases, only two, AK1 and AK2, fulfill the structural and functional criterion by the highest affinity for adenine nucleotides and the utilization of only AMP or dAMP as phosphate acceptors.	Adenine Nucleotides	120-139	adenylate kinase 2	Homo sapiens	39-42
26400880-4	2015	Among these kinases, only two, AK1 and AK2, fulfill the structural and functional criterion by the highest affinity for adenine nucleotides and the utilization of only AMP or dAMP as phosphate acceptors.	Adenosine Monophosphate	168-171	adenylate kinase 2	Homo sapiens	39-42
26400880-4	2015	Among these kinases, only two, AK1 and AK2, fulfill the structural and functional criterion by the highest affinity for adenine nucleotides and the utilization of only AMP or dAMP as phosphate acceptors.	Phosphates	183-192	adenylate kinase 2	Homo sapiens	39-42
24705759-1	2014	Adenylate kinase isozyme 2 (AK2) is located in mitochondrial intermembrane space and regulates energy metabolism by reversibly converting ATP and AMP to 2 ADPs.	Adenosine Triphosphate	138-141	adenylate kinase 2	Homo sapiens	28-31
24705759-1	2014	Adenylate kinase isozyme 2 (AK2) is located in mitochondrial intermembrane space and regulates energy metabolism by reversibly converting ATP and AMP to 2 ADPs.	Adenosine Monophosphate	146-149	adenylate kinase 2	Homo sapiens	28-31
24705759-1	2014	Adenylate kinase isozyme 2 (AK2) is located in mitochondrial intermembrane space and regulates energy metabolism by reversibly converting ATP and AMP to 2 ADPs.	adenosine 5'-O-(2-thiodiphosphate)	155-159	adenylate kinase 2	Homo sapiens	28-31
24548998-1	2014	Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein.	Adenine Nucleotides	41-59	adenylate kinase 2	Homo sapiens	20-23
20876536-5	2011	Here we find that adenylate kinase 2 (AK2), a mitochondrial enzyme that regulates adenine nucleotide interconversion within the intermembrane space, is markedly induced during adipocyte and B cell differentiation.	Adenine Nucleotides	82-100	adenylate kinase 2	Homo sapiens	18-36
22533503-3	2012	Therefore, EMHPs containing cell-binding domains (CBDs) were constructed from alpha,omega-azido-PEG and two types of alkyne-terminated AK2 peptides with sequences of DGRGX(AKAAAKA)(2)X (AK2-CBD1) and X(AKAAAKA)(2)XGGRGDSPG (AK2-CBD2, X = propargylglycine) via a step-growth, click coupling reaction.	Alkynes	117-123	adenylate kinase 2	Homo sapiens	135-138
22533503-4	2012	The resultant hybrid copolymers contain an estimated five to seven repeats of PEG and AK2 peptides.	copolymers	21-31	adenylate kinase 2	Homo sapiens	86-89
21457417-2	2011	METHODS AND RESULTS: Two bacterial strains, rK3 and aK2, were isolated from an epicatechin-converting human faecal suspension.	Catechin	79-90	adenylate kinase 2	Homo sapiens	52-55
21457417-9	2011	Flavonifractor plautii aK2 further converted 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol to 5-(3,4-dihydroxyphenyl)-gamma-valerolactone and 4-hydroxy-5-(3,4-dihydroxyphenyl)valeric acid.	1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol	45-106	adenylate kinase 2	Homo sapiens	23-26
21457417-9	2011	Flavonifractor plautii aK2 further converted 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol to 5-(3,4-dihydroxyphenyl)-gamma-valerolactone and 4-hydroxy-5-(3,4-dihydroxyphenyl)valeric acid.	(-)-5-(3',4'-dihydroxyphenyl)-valerolactone	110-153	adenylate kinase 2	Homo sapiens	23-26
21457417-9	2011	Flavonifractor plautii aK2 further converted 1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan-2-ol to 5-(3,4-dihydroxyphenyl)-gamma-valerolactone and 4-hydroxy-5-(3,4-dihydroxyphenyl)valeric acid.	4-Hydroxy-(3',4'-dihydroxyphenyl)-valeric acid	158-203	adenylate kinase 2	Homo sapiens	23-26
22533503-1	2012	We have synthesized elastin mimetic hybrid polymers (EMHPs) via the step-growth polymerization of azide-functionalized poly(ethylene glycol) (PEG) and alkyne-terminated peptide (AKAAAKA)(2) (AK2) that is abundant in the cross-linking domains of the natural elastin.	Polymers	43-51	adenylate kinase 2	Homo sapiens	191-194
22533503-1	2012	We have synthesized elastin mimetic hybrid polymers (EMHPs) via the step-growth polymerization of azide-functionalized poly(ethylene glycol) (PEG) and alkyne-terminated peptide (AKAAAKA)(2) (AK2) that is abundant in the cross-linking domains of the natural elastin.	Azides	98-103	adenylate kinase 2	Homo sapiens	191-194
20876536-5	2011	Here we find that adenylate kinase 2 (AK2), a mitochondrial enzyme that regulates adenine nucleotide interconversion within the intermembrane space, is markedly induced during adipocyte and B cell differentiation.	Adenine Nucleotides	82-100	adenylate kinase 2	Homo sapiens	38-41
17952061-3	2007	Downregulation of AK2 attenuates etoposide- or staurosporine-induced apoptosis in human cells, but not that induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) or Fas ligand (FasL).	Etoposide	33-42	adenylate kinase 2	Homo sapiens	18-21
21359141-2	2011	Towards this end, an alanine-based peptide doped with charged lysines with a sequence of (AKA(3)KA)(2) (AK2) was selected from the crosslinking regions of the natural elastin.	Alanine	21-28	adenylate kinase 2	Homo sapiens	104-107
17952061-3	2007	Downregulation of AK2 attenuates etoposide- or staurosporine-induced apoptosis in human cells, but not that induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) or Fas ligand (FasL).	Staurosporine	47-60	adenylate kinase 2	Homo sapiens	18-21
1901862-3	1991	To examine more closely the nature of this association, purified GP Ib-IX complex was specifically bound and oriented on the surface of impermeable polymer beads via a monoclonal antibody, AK 2, directed against the extracytoplasmic domain of GP Ib alpha (glycocalicin).	Polymers	148-155	adenylate kinase 2	Homo sapiens	189-193
34887922-11	2021	AK2 overexpression could restore the phenotype of BC cells blocked by miR-141-3p redevelopment.	mir-141-3p	70-80	adenylate kinase 2	Homo sapiens	0-3
34630090-1	2021	Adenylate kinase 2 (AK2) is a wide-spread and highly conserved protein kinase whose main function is to catalyze the exchange of nucleotide phosphate groups.	nucleotide phosphate	129-149	adenylate kinase 2	Homo sapiens	0-18
34630090-1	2021	Adenylate kinase 2 (AK2) is a wide-spread and highly conserved protein kinase whose main function is to catalyze the exchange of nucleotide phosphate groups.	nucleotide phosphate	129-149	adenylate kinase 2	Homo sapiens	20-23
35585049-0	2022	AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis.	Adenosine Monophosphate	10-13	adenylate kinase 2	Homo sapiens	0-3
35585049-2	2022	Adenylate kinase 2 (AK2), which modulates balance of adenine nucleotide pool, has been implicated in cell death and cell proliferation independently of its enzyme activity.	Adenine Nucleotides	53-71	adenylate kinase 2	Homo sapiens	0-18
35585049-2	2022	Adenylate kinase 2 (AK2), which modulates balance of adenine nucleotide pool, has been implicated in cell death and cell proliferation independently of its enzyme activity.	Adenine Nucleotides	53-71	adenylate kinase 2	Homo sapiens	20-23
35585049-6	2022	Energy-deprived conditions in cell model and the addition of AMP to cell lysates strengthened the AK2-BRAF interaction, suggesting that AK2 is involved in the regulation of BRAF activity in response to cell metabolic state.	Adenosine Monophosphate	61-64	adenylate kinase 2	Homo sapiens	98-101
35585049-6	2022	Energy-deprived conditions in cell model and the addition of AMP to cell lysates strengthened the AK2-BRAF interaction, suggesting that AK2 is involved in the regulation of BRAF activity in response to cell metabolic state.	Adenosine Monophosphate	61-64	adenylate kinase 2	Homo sapiens	136-139
35585049-7	2022	AMP facilitated the AK2-BRAF complex formation through binding to AK2.	Adenosine Monophosphate	0-3	adenylate kinase 2	Homo sapiens	20-23
35585049-7	2022	AMP facilitated the AK2-BRAF complex formation through binding to AK2.	Adenosine Monophosphate	0-3	adenylate kinase 2	Homo sapiens	66-69