PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32887088-2	2020	Detection and quantitation limits were 0.31 ng muL-1 and 1.03 ng muL-1 respectively for anatase nanoparticles in capillary electrophoresis, and a high amount of titanium was found in the samples subject to study (lip balm and two types of toothpaste) by total elemental analysis.	Titanium	161-169	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	47-52
33676694-5	2021	Thanks to the recognition sites of phosphate and the template-shaped cavities, Fe3O4@TiO2@Lys MIPs showed great sensitivity (0.01 ng*muL-1) and selectivity (Lysozyme: BSA: beta-casein = 1:100:100, mass ratio) in standard phosphoprotein solution.	Phosphates	35-44	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	133-138
33676694-5	2021	Thanks to the recognition sites of phosphate and the template-shaped cavities, Fe3O4@TiO2@Lys MIPs showed great sensitivity (0.01 ng*muL-1) and selectivity (Lysozyme: BSA: beta-casein = 1:100:100, mass ratio) in standard phosphoprotein solution.	ferryl iron	79-84	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	133-138
33676694-5	2021	Thanks to the recognition sites of phosphate and the template-shaped cavities, Fe3O4@TiO2@Lys MIPs showed great sensitivity (0.01 ng*muL-1) and selectivity (Lysozyme: BSA: beta-casein = 1:100:100, mass ratio) in standard phosphoprotein solution.	titanium dioxide	85-89	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	133-138
33676694-5	2021	Thanks to the recognition sites of phosphate and the template-shaped cavities, Fe3O4@TiO2@Lys MIPs showed great sensitivity (0.01 ng*muL-1) and selectivity (Lysozyme: BSA: beta-casein = 1:100:100, mass ratio) in standard phosphoprotein solution.	lys mips	90-98	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	133-138
33400793-5	2021	In this study we exposed such a model to tritiated water (HTO) for 24 h, with a range of activity levels (up to ~33 kBq mul-1 cm-2).	Water	51-56	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	120-125
33400793-5	2021	In this study we exposed such a model to tritiated water (HTO) for 24 h, with a range of activity levels (up to ~33 kBq mul-1 cm-2).	(2R,3R)-heptane-1,2,3-triol	58-61	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	120-125
33326925-4	2021	The resulting C18VK-VI-GO@Fe3O4 MNCs exhibited good performance for peptides enrichment from digests of standard protein (myoglobin, MYO) and human serum, such as high sensitivity (0.05 fmol muL-1) and selectivity (mass ratio of MYO digests and MYO = 1:500), rapid separation, and good reproducibility.	ferryl iron	26-31	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	191-196
33461709-4	2021	With the aid of Au nanoparticles, this method shows a good linear range from 0.0042 mug muL-1 to 0.0210 mug muL -1 with a correlation coefficient of 0.9350 and a low limit of detection 0.00098 mug muL -1.	Gold	16-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	88-93
33461709-4	2021	With the aid of Au nanoparticles, this method shows a good linear range from 0.0042 mug muL-1 to 0.0210 mug muL -1 with a correlation coefficient of 0.9350 and a low limit of detection 0.00098 mug muL -1.	Gold	16-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	108-114
33461709-4	2021	With the aid of Au nanoparticles, this method shows a good linear range from 0.0042 mug muL-1 to 0.0210 mug muL -1 with a correlation coefficient of 0.9350 and a low limit of detection 0.00098 mug muL -1.	Gold	16-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	197-203
33461719-6	2021	As expected, Fe3O4@mPDA@Ti4+ revealed a great selectivity (1:200) and a low detection limit (0.1 fmol muL-1) toward phosphopeptides.	ferryl iron	13-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	102-107
33461719-6	2021	As expected, Fe3O4@mPDA@Ti4+ revealed a great selectivity (1:200) and a low detection limit (0.1 fmol muL-1) toward phosphopeptides.	3-(2'-pyridyldithio)benzyldiazoacetate	19-23	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	102-107
33461719-6	2021	As expected, Fe3O4@mPDA@Ti4+ revealed a great selectivity (1:200) and a low detection limit (0.1 fmol muL-1) toward phosphopeptides.	Phosphopeptides	116-131	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	102-107
33280689-5	2021	And the linear calibration curve of propofol was obtained with the range of 0.1-15 ng muL-1 and with the limit of detection of 0.03 ng muL-1, which was fulfilled to conduct propofol determination throughout the perioperative period.	Propofol	36-44	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	86-91
33280689-5	2021	And the linear calibration curve of propofol was obtained with the range of 0.1-15 ng muL-1 and with the limit of detection of 0.03 ng muL-1, which was fulfilled to conduct propofol determination throughout the perioperative period.	Propofol	36-44	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	135-140
33280689-5	2021	And the linear calibration curve of propofol was obtained with the range of 0.1-15 ng muL-1 and with the limit of detection of 0.03 ng muL-1, which was fulfilled to conduct propofol determination throughout the perioperative period.	Propofol	173-181	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	86-91
33280689-5	2021	And the linear calibration curve of propofol was obtained with the range of 0.1-15 ng muL-1 and with the limit of detection of 0.03 ng muL-1, which was fulfilled to conduct propofol determination throughout the perioperative period.	Propofol	173-181	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	135-140
33280689-6	2021	Finally, this method was applied to clinically measure the blood propofol concentration in patients newly regained consciousness with concentrations ranging from 0.2 ng muL-1 to 3 ng muL-1, and it turned out that the older patient had the lower propofol concentration in blood.	Propofol	65-73	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	169-179
33280689-6	2021	Finally, this method was applied to clinically measure the blood propofol concentration in patients newly regained consciousness with concentrations ranging from 0.2 ng muL-1 to 3 ng muL-1, and it turned out that the older patient had the lower propofol concentration in blood.	Propofol	65-73	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	169-174
32803303-5	2020	Limits of quantitation (LOQ) ranged from 4 to 20 pg muL-1 ethyl acetate (PDMS extract) for pesticides and persistent organic pollutants (POPs).	ethyl acetate	58-71	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	52-57
33073321-4	2020	Benefitting from the merits of Zr-MOF and glucose-6-phosphate, the as-designed composite exhibits good selectivity (the mass ratio of HRP digests to BSA digests was up to1:200) and low limit of detection (0.1 fmol muL-1) towards the recognition of glycopeptides from standard samples.	Glycopeptides	248-261	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	214-219
31174130-3	2019	The selectivity and sensitivity (0.5 fmol muL-1) of the titania-based sol-gel material was found to be quite high when compared with commercial TiO2.	titanium dioxide	144-148	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	42-47
32379252-7	2020	Fe3O4@SiO2@TpPa-Ti4+ nanoparticles also demonstrate high sensitivity (above 0.2 fmol muL-1) and selectivity (alpha-casein : BSA = 1 : 5000).	ferryl iron	0-5	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	85-90
32379252-7	2020	Fe3O4@SiO2@TpPa-Ti4+ nanoparticles also demonstrate high sensitivity (above 0.2 fmol muL-1) and selectivity (alpha-casein : BSA = 1 : 5000).	Silicon Dioxide	6-10	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	85-90
32379252-7	2020	Fe3O4@SiO2@TpPa-Ti4+ nanoparticles also demonstrate high sensitivity (above 0.2 fmol muL-1) and selectivity (alpha-casein : BSA = 1 : 5000).	triphenyl phosphate	11-15	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	85-90
32379252-7	2020	Fe3O4@SiO2@TpPa-Ti4+ nanoparticles also demonstrate high sensitivity (above 0.2 fmol muL-1) and selectivity (alpha-casein : BSA = 1 : 5000).	ti4+	16-20	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	85-90
32235706-6	2020	The SERS readout was directly proportional to the PKA activity in a wide range of 0.0001-0.5 U muL-1 with a detection limit as low as 0.00003 U muL-1.	sers	4-8	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	95-100
32235706-6	2020	The SERS readout was directly proportional to the PKA activity in a wide range of 0.0001-0.5 U muL-1 with a detection limit as low as 0.00003 U muL-1.	sers	4-8	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	144-149
31948586-4	2020	Under optimized conditions, a linear calibration curve of propofol was obtained with the range of 0.5-20 ng muL-1 and with a limit of detection of 0.14 ng muL-1, which met the clinical requirements and correlated well with standard HPLC methods.	Propofol	58-66	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	108-113
31948586-4	2020	Under optimized conditions, a linear calibration curve of propofol was obtained with the range of 0.5-20 ng muL-1 and with a limit of detection of 0.14 ng muL-1, which met the clinical requirements and correlated well with standard HPLC methods.	Propofol	58-66	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	155-160
32001742-0	2020	Gemcitabine induces Parkin-independent mitophagy through mitochondrial-resident E3 ligase MUL1-mediated stabilization of PINK1.	gemcitabine	0-11	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	90-94
31519232-7	2019	The proposed method provided satisfactory recoveries (76-119%) and limits of detection: 2.1-4.4 pg muL-1 for tri-heptaBDE in linear range of 5-100 pg muL-1; 480 pg muL-1 for decaBDE in linear range of 500-2000 pg muL-1 from only 0.05 g of a dust sample.	tri-heptabde	109-121	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	99-104
31519232-7	2019	The proposed method provided satisfactory recoveries (76-119%) and limits of detection: 2.1-4.4 pg muL-1 for tri-heptaBDE in linear range of 5-100 pg muL-1; 480 pg muL-1 for decaBDE in linear range of 500-2000 pg muL-1 from only 0.05 g of a dust sample.	tri-heptabde	109-121	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	150-155
31519232-7	2019	The proposed method provided satisfactory recoveries (76-119%) and limits of detection: 2.1-4.4 pg muL-1 for tri-heptaBDE in linear range of 5-100 pg muL-1; 480 pg muL-1 for decaBDE in linear range of 500-2000 pg muL-1 from only 0.05 g of a dust sample.	tri-heptabde	109-121	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	150-155
31519232-7	2019	The proposed method provided satisfactory recoveries (76-119%) and limits of detection: 2.1-4.4 pg muL-1 for tri-heptaBDE in linear range of 5-100 pg muL-1; 480 pg muL-1 for decaBDE in linear range of 500-2000 pg muL-1 from only 0.05 g of a dust sample.	tri-heptabde	109-121	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	150-155
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	79-90
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	79-84
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	97-102
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	200-214
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	97-102
31357320-4	2019	The LOD and LOQ for diethofencarb at 3D MoS2NTs/GCE were calculated as 0.32 ng muL-1 and 1.09 ng muL-1 in the concentration range of 1-55 ng muL-1 by square wave voltammetry (SWV) and further 0.63 ng muL-1 and 2.11 ng muL-1 in the concentration range of 1-35 ng muL-1 by differential pulse voltammetry (DPV).	diethofencarb	20-33	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	97-102
31542921-6	2019	Concentrations of Ti-containing NP between 27 and 193 muL-1 were found in rain samples.	Titanium	18-20	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
32281356-3	2020	After pancreatic cancer Panc-1 cells were treated with polyphyllin D(0, 1, 2, 3, 4, 5 mug muL~(-1)) for 24, 48 and 72 hours, CCK-8 method was used to detect the effect of polyphyllin D on the proliferation of pancreatic cancer Panc-1 cells.	polyphyllin D	55-68	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	90-97
31967178-5	2020	The extremely abundant amine groups of PAMAM-PMAA brushes and superparamagnetism of the Fe3O4 core endowed the composite nanospheres with high detection sensitivity (1 fmol muL-1), excellent selectivity (1 : 500 molar ratios of beta-casein/BSA) and high recyclability (five cycles) towards phosphopeptides.	methacrylic acid	45-49	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	173-178
31967178-5	2020	The extremely abundant amine groups of PAMAM-PMAA brushes and superparamagnetism of the Fe3O4 core endowed the composite nanospheres with high detection sensitivity (1 fmol muL-1), excellent selectivity (1 : 500 molar ratios of beta-casein/BSA) and high recyclability (five cycles) towards phosphopeptides.	ferryl iron	88-93	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	173-178
31883575-2	2020	Since the SiO2@L-Cys capillary packed column possessed great hydrophilicity brought by L-cysteine, they could be utilized to enrich glycopeptides with a low detection limit of 5 fmol muL-1 HRP digests as well as a good selectivity of the mixture of HRP and BSA digests up to a molar ratio of 1:50.	Silicon	10-14	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	183-188
31883575-2	2020	Since the SiO2@L-Cys capillary packed column possessed great hydrophilicity brought by L-cysteine, they could be utilized to enrich glycopeptides with a low detection limit of 5 fmol muL-1 HRP digests as well as a good selectivity of the mixture of HRP and BSA digests up to a molar ratio of 1:50.	Cysteine	15-20	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	183-188
31883575-2	2020	Since the SiO2@L-Cys capillary packed column possessed great hydrophilicity brought by L-cysteine, they could be utilized to enrich glycopeptides with a low detection limit of 5 fmol muL-1 HRP digests as well as a good selectivity of the mixture of HRP and BSA digests up to a molar ratio of 1:50.	Cysteine	87-97	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	183-188
32001742-8	2020	These results suggest that gemcitabine induces mitophagy through MUL1-mediated stabilization of PINK1 on the mitochondrial membrane independently of mitochondrial depolarization.	gemcitabine	27-38	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	65-69
31929179-2	2020	The C-terminal region of MUL1 faces the cytoplasm and contains the RING domain (MUL1-RING) where the Ub~E2 thioester binds.	Carbon	4-5	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	25-29
31929179-2	2020	The C-terminal region of MUL1 faces the cytoplasm and contains the RING domain (MUL1-RING) where the Ub~E2 thioester binds.	Carbon	4-5	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	80-84
31929179-2	2020	The C-terminal region of MUL1 faces the cytoplasm and contains the RING domain (MUL1-RING) where the Ub~E2 thioester binds.	Cy5-benzyl thioester	107-116	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	25-29
31929179-2	2020	The C-terminal region of MUL1 faces the cytoplasm and contains the RING domain (MUL1-RING) where the Ub~E2 thioester binds.	Cy5-benzyl thioester	107-116	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	80-84
31750645-4	2019	The as-prepared MCNC@COF@GSH microspheres possessed fast magnetic responsiveness, regular porosity, large surface areas, and good hydrophilicity, resulting in remarkable performances in N-linked glycopeptide enrichment with low detection limit (0.01 fmol muL-1), high selectivity (1:5000, human IgG digests to bovine serum albumin digests), excellent size-exclusion effect (IgG digests/IgG/BSA, 1:500:500), and reusability (at least five times).	Glutathione	25-28	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	255-260
31750645-4	2019	The as-prepared MCNC@COF@GSH microspheres possessed fast magnetic responsiveness, regular porosity, large surface areas, and good hydrophilicity, resulting in remarkable performances in N-linked glycopeptide enrichment with low detection limit (0.01 fmol muL-1), high selectivity (1:5000, human IgG digests to bovine serum albumin digests), excellent size-exclusion effect (IgG digests/IgG/BSA, 1:500:500), and reusability (at least five times).	Nitrogen	18-19	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	255-260
31364612-4	2019	For a standard protein ovalbumin digest, 26 N-linked glycans were identified with good repeatability, and the detection limit was as low as 0.25 ng muL-1 with the identification of 13 N-linked glycans (S/N > 10).	n-linked glycans	184-200	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	148-153
30747410-3	2019	By using the QLD tag, the detection limit of GSH was lowered to 10 fmol muL-1, which was four orders of magnitude higher than that detected without using the QLD tag.	Glutathione	45-48	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	72-77
30816444-0	2019	MUL1 E3 ligase regulates the antitumor effects of metformin in chemoresistant ovarian cancer cells via AKT degradation.	Metformin	50-59	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	0-4
30816444-3	2019	The current study revealed that the novel antitumor mechanism of metformin is mediated by regulation of mitochondrial E3 ubiquitin protein ligase 1 (MUL1) expression that negatively regulates AKT.	Metformin	65-74	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	104-147
30816444-3	2019	The current study revealed that the novel antitumor mechanism of metformin is mediated by regulation of mitochondrial E3 ubiquitin protein ligase 1 (MUL1) expression that negatively regulates AKT.	Metformin	65-74	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	149-153
30816444-4	2019	The results demonstrated that metformin decreased the expression of AKT protein levels via MUL1 E3 ligase.	Metformin	30-39	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	91-95
30816444-5	2019	In addition, metformin increased both mRNA and protein levels of MUL1 and promoted degradation of AKT in a proteasome-dependent manner.	Metformin	13-22	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	65-69
30816444-6	2019	Silencing MUL1 expression suppressed the metformin-mediated AKT degradation and its downstream effects.	Metformin	41-50	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	10-14
30816444-7	2019	Cell cycle analysis and a clonogenic assay demonstrated that knockdown of MUL1 significantly diminished the antitumor effects of metformin.	Metformin	129-138	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	74-78
30816444-8	2019	Together, these data indicate that MUL1 regulates metformin-mediated AKT degradation and the antitumor effects of metformin in chemoresistant ovarian cancer cell lines.	Metformin	50-59	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	35-39
30816444-8	2019	Together, these data indicate that MUL1 regulates metformin-mediated AKT degradation and the antitumor effects of metformin in chemoresistant ovarian cancer cell lines.	Metformin	114-123	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	35-39
30872404-0	2019	Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.	Ribonucleotides	121-135	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	48-67
30818192-7	2019	With depth, stronger anoxic conditions resulted in the dominance of reductive hydrolysis leading to a co-occurrence scenario of As (max 4.6 mugL-1) with Zn (max 2514 mugL-1) and Pb (max 740 muL-1) with influences of anthropogenic modes of activities like agriculture and dry deposition from a brick kiln.	Arsenic	128-130	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	190-195
31157769-0	2019	Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs.	pomalidomide	61-73	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	29-48
31157769-1	2019	The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiquitin ligase for proteasomal degradation.	Thalidomide	35-46	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	291-310
31157769-1	2019	The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiquitin ligase for proteasomal degradation.	Lenalidomide	64-76	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	291-310
31157769-1	2019	The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiquitin ligase for proteasomal degradation.	pomalidomide	81-93	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	291-310
29957292-4	2018	Under this condition, the chemical oxygen demand (COD) removal efficiency, dehydrogenase activities, and the viability of microorganisms reached 62.7%, 55.7 TF muL-1, and 78.4%, respectively, which were 115.4%, 77.2%, and 20.3% higher than those without the addition of potassium chloride.	Oxygen	35-41	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	160-165
29299162-5	2017	Here we report that cisplatin (CDDP) induces thyroid cancer cell death through MUL1-AKT axis.	Cisplatin	20-29	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	79-83
28963785-8	2018	Furthermore, the TTC3 and MUL1 shRNA adenovirus dramatically decreased the Akt ubiquitination and apoptosis induced by nicotine.	Nicotine	119-127	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	26-30
28963785-9	2018	These results indicate that nicotine-induced Akt ubiquitination and degradation occurs through TTC3 and MUL1 and results in a dramatic increase in apoptosis in HUVECs cultured in HG/HF media.	Nicotine	28-36	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	104-108
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	21-25
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	26-31
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	32-36
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	37-41
29260979-5	2018	However, NTS-induced MUL1/MULAN/GIDE/MAPL (mitochondrial ubiquitin ligase activator of NFKB 1) leads to downregulation of HSPA5 via K48-linked ubiquitination at the lysine 446 (K446) residue.	Lysine	165-171	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	43-93
29920571-4	2018	Endowed with the high hydrophilicity of glutathione, the large surface area of the MOF and strong magnetic responsiveness of magnetic nanoparticles, the as-prepared mMOF@Au@GSH exhibited high selectivity (1 : 100) and great sensitivity (0.5 fmol muL-1) towards glycopeptides.	Glutathione	173-176	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	246-251
29580989-6	2018	Our results also showed that AICAR treatment or nutrient depletion increases FOXO3 expression in primary myotubes and the expression of the mitochondrial E3 ligase Mul1 involved in mitochondrial turnover (mitophagy).	AICA ribonucleotide	29-34	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	164-168
29258448-12	2017	DAFH >4% occurred in 334 of 719 children; its predictors were history of fever pre-and fever 1 day post-treatment initiation, haematocrit >=37%, and parasitaemia >100,000 muL-1.	dafh	0-4	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	180-185
29299162-5	2017	Here we report that cisplatin (CDDP) induces thyroid cancer cell death through MUL1-AKT axis.	Cisplatin	31-35	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	79-83
29299162-6	2017	Specifically, CDDP-induced MUL1 leads to ubiquitylation of active form of AKT.	Cisplatin	14-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	27-31
29299162-7	2017	We also observed that the role of forkhead box O3 (FOXO3) is pivotal in CDDP-induced MUL1 regulation.	Cisplatin	72-76	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	85-89
29299162-8	2017	FOXO3 knock-downed cells show resistance against CDDP-mediated MUL1-AKT axis.	Cisplatin	49-53	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	63-67
29299162-9	2017	CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway.	Cisplatin	0-4	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	75-79
29299162-9	2017	CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway.	ros	28-31	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	75-79
29299162-10	2017	The data provide compelling evidence to support the idea that the regulation of FOXO3-MUL1-AKT axis can be a novel strategy for the treatment of HNC with CDDP.	Cisplatin	154-158	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	86-90
28273895-4	2017	A biotin environment scan of MAPL interacting polypeptides identified a series of proteins specific to Sendai virus infection; including RIG-I, IFIT1, IFIT2, HERC5 and others.	Biotin	2-8	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	29-33
29158701-6	2017	Besides, the decrease in the pUC19 plasmid DNA damage after addition of catalase (1.0 x 10-4 mg muL-1) in the same reaction medium indicates that H2O2 is also involved in the damage process.	Hydrogen Peroxide	146-150	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	96-101
32264225-6	2017	Based on the HPLC-Q-TOF/MS results, 29 hydrophobic peptides assigned to 12 proteins were clearly identified in 5 ng muL-1 human serum digestion upon treatment with Fe3O4@TbBd nanospheres, much better than those obtained without treatment, confirming the outstanding performance of the Fe3O4@TbBd nanospheres in proteome analysis.	ferryl iron	164-169	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	116-121
32264225-6	2017	Based on the HPLC-Q-TOF/MS results, 29 hydrophobic peptides assigned to 12 proteins were clearly identified in 5 ng muL-1 human serum digestion upon treatment with Fe3O4@TbBd nanospheres, much better than those obtained without treatment, confirming the outstanding performance of the Fe3O4@TbBd nanospheres in proteome analysis.	tbbd	170-174	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	116-121
32264225-6	2017	Based on the HPLC-Q-TOF/MS results, 29 hydrophobic peptides assigned to 12 proteins were clearly identified in 5 ng muL-1 human serum digestion upon treatment with Fe3O4@TbBd nanospheres, much better than those obtained without treatment, confirming the outstanding performance of the Fe3O4@TbBd nanospheres in proteome analysis.	ferryl iron	285-290	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	116-121
32264225-6	2017	Based on the HPLC-Q-TOF/MS results, 29 hydrophobic peptides assigned to 12 proteins were clearly identified in 5 ng muL-1 human serum digestion upon treatment with Fe3O4@TbBd nanospheres, much better than those obtained without treatment, confirming the outstanding performance of the Fe3O4@TbBd nanospheres in proteome analysis.	tbbd	291-295	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	116-121
28715013-4	2017	Accordingly, the MagG@COF-5 biocomposite showed excellent performance in N-linked glycopeptide analysis with a low detection limit (0.5 fmol muL-1), an excellent size-exclusion effect (HRP digests/BSA, 1 : 600), good recyclability and reusability.	Nitrogen	73-74	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	141-146
28595724-5	2017	The best performances in terms of both peak intensity and peak width were obtained by using the silica-based coating: the detection of the investigated compounds was feasible at low ng mul-1 levels with a good precision (RSD < 9% for polycyclic aromatic hydrocarbons and <11% for hormones).	Silicon Dioxide	96-102	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	185-190
28675223-8	2017	Moreover, melamine (63 +- 8.19 ng muL-1), a toxic compound, together with creatinine and paracetamol, was detected in urine samples, while lecithin was detected in food supplements.	melamine	10-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	34-39
28397383-15	2017	Likewise, circulating PMPs were reduced by ~75% in response to hyperthermia (from 256 +- 43 to 62 +- 14 microparticles mul-1 ).	pmps	22-26	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	119-124
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	Calcium Chloride	16-32	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	142-147
27783929-3	2016	We detected and characterized in considerable detail aperiodic fluctuations in the raw water following regional precipitation, with TCC increasing up to 50-fold from a dry weather baseline of approximately 120 cells mul-1 to an event peak of > 5000 cells mul-1.	Water	87-92	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	216-221
27783929-3	2016	We detected and characterized in considerable detail aperiodic fluctuations in the raw water following regional precipitation, with TCC increasing up to 50-fold from a dry weather baseline of approximately 120 cells mul-1 to an event peak of > 5000 cells mul-1.	Water	87-92	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	258-263
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	Calcium Chloride	16-32	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	252-257
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	bis(lactam)	38-49	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	142-147
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	bis(lactam)	38-49	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	252-257
27411017-1	2016	Complexation of calcium chloride with bis(lactam) ligand L1 allows the formation of both an unstable anhydrous complex, an aqua complex {[Ca2(mu-L1)2(H2O)9]Cl4]}n (1) and a related hydrate incorporating additional lattice water of crystallization {[Ca(mu-L1)(H2O)5]Cl2 H2O}n (2).	Water	222-227	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	142-147
25467517-5	2015	Using this strategy, photoproducts were detected from ~6 ng (200 ng muL(-1)) of DNA under a low UVB fluence of 65 J m(-2) for CPDs or 195 J m(-2) for 6-4PPs.	6-4pps	150-156	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	68-74
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ntp	99-102	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	20-24
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ntp	99-102	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	66-70
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ros	111-114	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	20-24
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ros	111-114	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	66-70
25863371-2	2015	Due to the large specific surface area of the hybrid matrix and the simplicity, rapidness and high efficiency of "thiol-ene" click reaction, the average coverage density of aptamer on the organic-silica hybrid monolith reached 420 pmol muL(-1).	2,3-Dihydrothiophene	114-123	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	236-242
25863371-2	2015	Due to the large specific surface area of the hybrid matrix and the simplicity, rapidness and high efficiency of "thiol-ene" click reaction, the average coverage density of aptamer on the organic-silica hybrid monolith reached 420 pmol muL(-1).	Silicon Dioxide	196-202	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	236-242
25627557-2	2015	Three nitro-PAHs were detected down to sub pg muL(-1) levels based on calculations from an instrumental signal-to-noise better than 3, which shows the feasibility of using the new materials in MALDI-TOF MS as a potential powerful analytical approach for the analysis of nitro-PAHs in PM2.5 samples.	nitro-pahs	6-16	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	46-52
26321632-6	2015	Suppression of MUL1 expression ameliorated MFN2 reduction and DA neuron loss but not alpha-synuclein accumulation.	Dopamine	62-64	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	15-19
25886951-9	2015	Urinary ATP was higher in association with female gender, voiding symptoms, pyuria greater than 10 wbc mul(-1) and negative MSU culture.	Adenosine Triphosphate	8-11	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	103-109
24282135-9	2014	Under optimal conditions, the limit of detection (S/N = 3) of this method for acrylamide was 2.1 microg kg(-1), and the RSD for five replicate extractions of 50 muL(-1) acrylamide was 4.5%.	Acrylamide	169-179	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	161-167
26018823-0	2015	Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy.	Selenious Acid	77-85	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	39-43
26018823-4	2015	Here we showed that MUL1, a mitochondria-localized E3 ligase, regulates selenite-induced mitophagy in an ATG5 and ULK1-dependent manner.	Selenious Acid	72-80	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	20-24
25335821-9	2014	Due to the high specific surface area of the hybrid silica-based monolith, the coverage density of DNA aptamers covalently immobilized in the capillaries was very high and reached 6.27 nmol muL(-1), thus leading to a capacity above 5 ng of OTA.	Silicon Dioxide	52-58	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	190-196
22244165-6	2012	When applied to aberrant methylation detection for the fragment of CDH4 gene, this system can discriminate over 0.5 ng muL(-1) sample DNA, which is superior to bisulfite sequencing or MSP and COBRA assays.	hydrogen sulfite	160-169	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	119-125
24636408-6	2014	Furthermore, the increased interaction between DNA and beads provided by DFA improved the limit of detection to 250 fg muL(-1).	Diphenylamine	73-76	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	119-125
23021802-8	2012	The developed method turned out to be linear within a far broader concentration range than the studied 0.0025-10 pg muL(-1) range entirely sufficient for analyses of PCB and PBDE in milk fat.	Halogenated Diphenyl Ethers	174-178	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	116-122
24338968-8	2014	Using our optimized method, stable carbon isotope ratios can be reliably measured in samples with concentrations of PAHs down to 0.05-0.1 ng muL(-1).	Carbon	35-41	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	141-147
24338968-8	2014	Using our optimized method, stable carbon isotope ratios can be reliably measured in samples with concentrations of PAHs down to 0.05-0.1 ng muL(-1).	Polycyclic Aromatic Hydrocarbons	116-120	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	141-147
25169519-4	2014	MATERIALS AND METHODS: C13orf18 and C1orf166 (MUL1 or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin- Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia.	Formaldehyde	168-176	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	36-44
25169519-4	2014	MATERIALS AND METHODS: C13orf18 and C1orf166 (MUL1 or Mulan) DNA methylation as potential biomarkers and risk factors was investigated in 112 liquid based cytology and Formalin-Fixed Paraffin- Embedded tissue specimens in Iranian females with cervical intraepithelial neoplasia and dysplasia.	Formaldehyde	168-176	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	46-50
31986751-4	2014	The HOMMS@PolyVPBA gave remarkable selectivity for glycopeptides even at a low molar ratio of glycopeptides/nonglycopeptides (1:50) with a very rapid enrichment speed (only 10 min) and low detection (1 ng muL-1 ).	4-vinylphenyl boronic acid	10-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	205-210
23675580-5	2013	Individual quaternary ammonium compounds were detected at low concentrations (<1 ng muL(-1)) and over a dynamic range of ~5 pg muL(-1) to 500 pg muL(-1) (ppb).	Quaternary Ammonium Compounds	11-40	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	87-93
23675580-5	2013	Individual quaternary ammonium compounds were detected at low concentrations (<1 ng muL(-1)) and over a dynamic range of ~5 pg muL(-1) to 500 pg muL(-1) (ppb).	Quaternary Ammonium Compounds	11-40	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	130-136
23675580-5	2013	Individual quaternary ammonium compounds were detected at low concentrations (<1 ng muL(-1)) and over a dynamic range of ~5 pg muL(-1) to 500 pg muL(-1) (ppb).	Quaternary Ammonium Compounds	11-40	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	130-136
22409309-5	2012	RESULTS AND CONCLUSIONS: The response rate (platelet count of >= 50,000 muL(-1) ) at week 6 of the 6-week double-blind phase was 60% in eltrombopag-treated patients and 0% in placebo-treated patients.	eltrombopag	139-150	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	75-81
21481404-1	2011	We have grafted temperature-responsive tethered poly(N-isopropylacrylamide) (PNIPAAm) onto silicon surfaces through atom transfer radical polymerization (ATRP) as a medium to extract human genomic DNA molecules from a biological specimen, namely human blood incorporating target DNA (hgDNA584) and control DNA (hgDNA528) at concentrations of 0.5, 1, and 50 ng muL(-1).	poly-N-isopropylacrylamide	48-75	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	360-366
22791425-10	2012	We describe the use of gold and gold:silver-alloy nanoprobes for the development of the non-cross-linking method to detect a specific BCR-ABL fusion gene (e.g., e1a2 and e14a2) mRNA target associated with chronic myeloid leukemia (CML) using 10 ng muL(-1) of unamplified total human RNA.	Silver	37-43	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	248-254
22122932-7	2012	The explanation for so high ACFs can be found in the extremely efficient retention mechanisms that the DeA-based SUPRAS provides for CPAHs (i.e. formation of hydrogen bonds and hydrophobic interactions), and the high number of binding sites that it contains (i.e. the concentration of biosurfactant in the SUPRAS was 0.56 mg muL(-1)).	dea	103-106	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	325-331
22122932-7	2012	The explanation for so high ACFs can be found in the extremely efficient retention mechanisms that the DeA-based SUPRAS provides for CPAHs (i.e. formation of hydrogen bonds and hydrophobic interactions), and the high number of binding sites that it contains (i.e. the concentration of biosurfactant in the SUPRAS was 0.56 mg muL(-1)).	cpahs	133-138	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	325-331
22122932-7	2012	The explanation for so high ACFs can be found in the extremely efficient retention mechanisms that the DeA-based SUPRAS provides for CPAHs (i.e. formation of hydrogen bonds and hydrophobic interactions), and the high number of binding sites that it contains (i.e. the concentration of biosurfactant in the SUPRAS was 0.56 mg muL(-1)).	Hydrogen	158-166	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	325-331
21481404-1	2011	We have grafted temperature-responsive tethered poly(N-isopropylacrylamide) (PNIPAAm) onto silicon surfaces through atom transfer radical polymerization (ATRP) as a medium to extract human genomic DNA molecules from a biological specimen, namely human blood incorporating target DNA (hgDNA584) and control DNA (hgDNA528) at concentrations of 0.5, 1, and 50 ng muL(-1).	poly-N-isopropylacrylamide	77-84	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	360-366
21481404-1	2011	We have grafted temperature-responsive tethered poly(N-isopropylacrylamide) (PNIPAAm) onto silicon surfaces through atom transfer radical polymerization (ATRP) as a medium to extract human genomic DNA molecules from a biological specimen, namely human blood incorporating target DNA (hgDNA584) and control DNA (hgDNA528) at concentrations of 0.5, 1, and 50 ng muL(-1).	Silicon	91-98	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	360-366
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	bidentate pyridylpyrazole	145-170	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
17944392-0	2007	[TDHF study of electronic absorption spectrum of (mu-L1) (mu-L2)-decacarbonyl triosmium].	tdhf	1-5	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	50-56
17944392-1	2007	Ab initio method was used to optimize the molecular geometry for a series of clusters (mu-L1) (mu-L2)- decacarbonyltri-osmium [L1, L2 = H, Cl, Br, I] at HF/CEP-4G level.	decacarbonyltri-osmium	103-125	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	87-93
21115185-4	2011	The hydrophilic proteins were more effective precursors of chloroform (35.9 mumol L(-1) at 120 min), 35 times greater than that from the hydrophobic proteins; whereas the hydrophobic proteins were more potent precursors of direct-acting mutagens (maximum level of 50.1 rev muL(-1) at 30 s) than the hydrophilic proteins (maximum level of 3.38 rev muL(-1) at 60 min).	Chloroform	59-69	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	273-279
21115185-4	2011	The hydrophilic proteins were more effective precursors of chloroform (35.9 mumol L(-1) at 120 min), 35 times greater than that from the hydrophobic proteins; whereas the hydrophobic proteins were more potent precursors of direct-acting mutagens (maximum level of 50.1 rev muL(-1) at 30 s) than the hydrophilic proteins (maximum level of 3.38 rev muL(-1) at 60 min).	Chloroform	59-69	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	347-353
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	Oxygen	17-25	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	Dimethylformamide	29-51	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	Dimethylformamide	53-56	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	meco2et	101-108	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	acetato-/pyrazolato	121-140	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	meco2	236-241	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
16547535-3	2006	Reaction of with dioxygen in N,N"-dimethylformamide (dmf) at 25 degrees C and subsequent workup with MeCO2Et afforded an acetato-/pyrazolato-bridged polymeric copper(II) compound [(mu-L1)Cu(mu-O2CMe)]n (2).	Copper	159-165	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	181-186
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	cu(ii)	97-103	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	cu(ii)	97-103	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	206-211
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	Copper	50-52	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	Copper	50-52	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	206-211
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	(4) pyrazolate	306-320	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
16547535-5	2006	The structural analysis of reveals a near-planar {Cu2(mu-L1)2}2+ core unit in which two adjacent Cu(II) ions are bridged by the deprotonated N,N-bidentate pyridylpyrazole units of two L1 and each such {Cu2(mu-L1)2}2+ unit is bridged by MeCO2- in a monodentate bridging mode [Cu...Cu separations (A): 3.9232(4) pyrazolate bridge; 3.3418(4) acetate bridge], providing a polymeric network.	Acetates	337-346	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	54-59
34762403-5	2021	Benefiting from the outstanding magnetic responsiveness and multiaffinity sites (Ti-O, Fe-O, and NH2 groups), the Fe3O4/TiO2@Ti3C2Tx composites possessed excellent enrichment performance with high sensitivity (0.1 fmol muL-1), excellent selectivity (beta-casein: bovine serum albumin = 1:5000, molar ratio), good repeatability (5 times), and high enrichment capacity (200 mg g-1).	ferryl iron	114-119	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	219-224
34479085-6	2022	Furthermore, excellent salt and protein tolerance, good repeatability and quantification were observed when MNZ and its metabolites were detected in the range of 1-50 ng muL-1 (R2 > 0.98), with LODs and LOQs of 0.5 ng muL-1 and 1 ng muL-1, respectively.	(4~{a}~{R},5~{S},6~{R},8~{S},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-8-oxidanyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid	108-111	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	170-175
34479085-6	2022	Furthermore, excellent salt and protein tolerance, good repeatability and quantification were observed when MNZ and its metabolites were detected in the range of 1-50 ng muL-1 (R2 > 0.98), with LODs and LOQs of 0.5 ng muL-1 and 1 ng muL-1, respectively.	(4~{a}~{R},5~{S},6~{R},8~{S},8~{a}~{R})-5-[2-(furan-3-yl)ethyl]-5,6,8~{a}-trimethyl-8-oxidanyl-3,4,4~{a},6,7,8-hexahydronaphthalene-1-carboxylic acid	108-111	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	218-229
34495376-9	2021	The number of PMPs increased significantly with both rivaroxaban (365.2 +- 372.1 vs 237.4 +- 157.1 mul-1, p = 0.005) and aspirin (266.0 +- 212.7 vs 201.7 +- 162.7 mul-1, p = 0.021).	pmps	14-18	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	163-168
34495376-9	2021	The number of PMPs increased significantly with both rivaroxaban (365.2 +- 372.1 vs 237.4 +- 157.1 mul-1, p = 0.005) and aspirin (266.0 +- 212.7 vs 201.7 +- 162.7 mul-1, p = 0.021).	Rivaroxaban	53-64	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	99-104
34761928-2	2021	The detection limit of the CHCA-GSH conjugate decreased to 200 pmol muL-1, which was 2 orders of magnitude lower than that of pure GSH.Forapplication, CHCA was successfully applied for the detection of GSH, present in HepG2 cell lysates.	Glutathione	32-35	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	68-73
34761928-2	2021	The detection limit of the CHCA-GSH conjugate decreased to 200 pmol muL-1, which was 2 orders of magnitude lower than that of pure GSH.Forapplication, CHCA was successfully applied for the detection of GSH, present in HepG2 cell lysates.	Glutathione	202-205	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	68-73
16390052-0	2006	Syntheses, crystal structures, and magneto-structural correlations of novel Cu(II) complexes containing a planar [Cu(mu-L1)]2 (HL1 = 3-(2-pyridyl)pyrazole) unit: from dinuclear to tetranuclear and then to one-dimensional compounds.	cu(ii)	76-82	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	117-122
16390052-0	2006	Syntheses, crystal structures, and magneto-structural correlations of novel Cu(II) complexes containing a planar [Cu(mu-L1)]2 (HL1 = 3-(2-pyridyl)pyrazole) unit: from dinuclear to tetranuclear and then to one-dimensional compounds.	-pyridyl)pyrazole	137-154	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	117-122
34762403-5	2021	Benefiting from the outstanding magnetic responsiveness and multiaffinity sites (Ti-O, Fe-O, and NH2 groups), the Fe3O4/TiO2@Ti3C2Tx composites possessed excellent enrichment performance with high sensitivity (0.1 fmol muL-1), excellent selectivity (beta-casein: bovine serum albumin = 1:5000, molar ratio), good repeatability (5 times), and high enrichment capacity (200 mg g-1).	titanium dioxide	120-124	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	219-224
34322908-8	2021	Fascinatingly, the peroxisome elongation caused either due to silencing of DRP1 or by addition of polyunsaturated fatty acid, docosahexaenoic acid was blocked by overexpressing MAPL in mammalian cell lines.	Fatty Acids, Unsaturated	98-124	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	177-181
34322908-8	2021	Fascinatingly, the peroxisome elongation caused either due to silencing of DRP1 or by addition of polyunsaturated fatty acid, docosahexaenoic acid was blocked by overexpressing MAPL in mammalian cell lines.	Docosahexaenoic Acids	126-146	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	177-181
34322908-11	2021	The results of polyethylene glycol-based cell-cell fusion assay signified that the enrichment of MAPL in peroxisomes is through vesicles and a retromer dependent phenomenon.	Polyethylene Glycols	15-34	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	97-101
35403181-7	2022	A methanol extract of precipitates exhibited a potent anti-proliferative effect on MCF-7 cells (IC50 = 0.032 mug muL-1) via inhibiting tubulin polymerization.	Methanol	2-10	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	113-118
34296732-7	2021	The inherent properties endowed the nanocomposite with excellent enrichment performance for N-glycopeptides: excellent selectivity (1 : 2000, IgG/BSA, m/m), an ultralow detection limit (0.05 fmol muL-1), and a good size-exclusion effect (1 : 500, IgG digests/BSA, m/m).	n-glycopeptides	92-107	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	196-201
34140641-0	2021	The HSF1/miR-135b-5p axis induces protective autophagy to promote oxaliplatin resistance through the MUL1/ULK1 pathway in colorectal cancer.	Oxaliplatin	66-77	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	101-105
35194034-8	2022	We found that DRAK1 protein was destabilized through K48-linked polyubiquitination promoted by the Cullin scaffold protein 3 (CUL3) / speckle-type POZ (poxvirus and zinc finger protein) protein (SPOP) E3 ubiquitin ligase in paclitaxel-resistant cells.	Paclitaxel	224-234	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	201-220
35182004-4	2022	This material manifests excellent property in glycopeptides enrichment, with high selectivity (1:5000), low detection limit (0.1 fmol muL-1 ), high recovery rate (99.4 +- 0.5%) and good repeatability.	Glycopeptides	46-59	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	134-139
35244662-3	2022	Owing to its strong magnetic property, large surface area (845 m2 g-1), excellent hydrophilicity and suitable porous structure, the GO@Fe3O4@MOF-303 probe exhibits an ultralow detection limit (0.1 fmol muL-1), perfect size-exclusion effect (HRP digests/BSA protein/HRP protein, 1 : 1000 : 1000, w/w/w), a high binding capacity (200 mg g-1) and excellent reusability in the capture of standard N-linked glycopeptides.	ferryl iron	135-140	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	202-207
35244662-3	2022	Owing to its strong magnetic property, large surface area (845 m2 g-1), excellent hydrophilicity and suitable porous structure, the GO@Fe3O4@MOF-303 probe exhibits an ultralow detection limit (0.1 fmol muL-1), perfect size-exclusion effect (HRP digests/BSA protein/HRP protein, 1 : 1000 : 1000, w/w/w), a high binding capacity (200 mg g-1) and excellent reusability in the capture of standard N-linked glycopeptides.	n-linked glycopeptides	393-415	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	202-207
35013145-6	2022	APP-CTFs accumulation also resulted in mitophagy failure, as validated by increased LC3-II and p62 and inconsistent PTEN-induced kinase 1 (PINK1)/E3 ubiquitin ligase (Parkin) recruitment to mitochondria and failed fusion of mitochondria and lysosomes.	app-ctfs	0-8	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	146-165
35048531-0	2022	MUL1-RING recruits the substrate, p53-TAD as a complex with UBE2D2-UB conjugate.	BM	67-69	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	0-4