PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	90-93	glutathione S-transferase zeta 1	Homo sapiens	30-35
21303221-9	2011	Proteomic analysis showed that hGSTZ1-1 was inactivated when Cys-16 was modified by glutathione and the carbon skeleton of DCA.	Cysteine	61-64	glutathione S-transferase zeta 1	Homo sapiens	31-39
21303221-9	2011	Proteomic analysis showed that hGSTZ1-1 was inactivated when Cys-16 was modified by glutathione and the carbon skeleton of DCA.	Glutathione	84-95	glutathione S-transferase zeta 1	Homo sapiens	31-39
21303221-9	2011	Proteomic analysis showed that hGSTZ1-1 was inactivated when Cys-16 was modified by glutathione and the carbon skeleton of DCA.	Carbon	104-110	glutathione S-transferase zeta 1	Homo sapiens	31-39
21303221-9	2011	Proteomic analysis showed that hGSTZ1-1 was inactivated when Cys-16 was modified by glutathione and the carbon skeleton of DCA.	Dichloroacetic Acid	123-126	glutathione S-transferase zeta 1	Homo sapiens	31-39
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	90-93	glutathione S-transferase zeta 1	Homo sapiens	36-40
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Tyrosine	136-144	glutathione S-transferase zeta 1	Homo sapiens	30-35
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Tyrosine	136-144	glutathione S-transferase zeta 1	Homo sapiens	36-40
20920954-10	2011	Age and GSTz1/MAAI haplotype can markedly affect the toxicokinetics of DCA in humans and rodents.	Dichloroacetic Acid	71-74	glutathione S-transferase zeta 1	Homo sapiens	8-13
20920954-10	2011	Age and GSTz1/MAAI haplotype can markedly affect the toxicokinetics of DCA in humans and rodents.	Dichloroacetic Acid	71-74	glutathione S-transferase zeta 1	Homo sapiens	14-18
20884751-5	2011	Immunoreactive GSTZ1 was detected in liver mitochondria from humans and rats, and its identity was confirmed by liquid chromatography/tandem mass spectrometry analysis of the tryptic peptides.	Peptides	183-191	glutathione S-transferase zeta 1	Homo sapiens	15-20
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	73-102
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	107-135
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	137-142
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	143-147
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	glyoxylic acid	35-45	glutathione S-transferase zeta 1	Homo sapiens	73-102
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	glyoxylic acid	35-45	glutathione S-transferase zeta 1	Homo sapiens	107-135
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	glyoxylic acid	35-45	glutathione S-transferase zeta 1	Homo sapiens	137-142
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	glyoxylic acid	35-45	glutathione S-transferase zeta 1	Homo sapiens	143-147
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Phenylalanine	199-212	glutathione S-transferase zeta 1	Homo sapiens	73-102
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Phenylalanine	199-212	glutathione S-transferase zeta 1	Homo sapiens	107-135
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Phenylalanine	199-212	glutathione S-transferase zeta 1	Homo sapiens	137-142
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Phenylalanine	199-212	glutathione S-transferase zeta 1	Homo sapiens	143-147
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Tyrosine	217-225	glutathione S-transferase zeta 1	Homo sapiens	73-102
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Tyrosine	217-225	glutathione S-transferase zeta 1	Homo sapiens	107-135
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Tyrosine	217-225	glutathione S-transferase zeta 1	Homo sapiens	137-142
20920954-8	2011	DCA is primarily biotransformed to glyoxylate by the bifunctional enzyme glutathione transferase zeta1 and maleylacetoacetate isomerase (GSTz1/MAAI), which also catalyzes the penultimate step in the phenylalanine and tyrosine catabolic pathway.	Tyrosine	217-225	glutathione S-transferase zeta 1	Homo sapiens	143-147
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	30-35
20920954-9	2011	DCA is a suicide inhibitor of GSTz1/MAAI, which can result in delayed plasma clearance of DCA and the accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	36-40
18824004-10	2008	MPI has significant sequence similarity to maleylacetoacetate isomerase (MAAI), which performs an analogous reaction in the catabolism of phenylalanine and tyrosine.	Phenylalanine	138-151	glutathione S-transferase zeta 1	Homo sapiens	43-71
20675267-7	2010	Among the 195 cases and 192 controls with high-risk forms of GSTT1 and GSTZ1, the ORs for quartiles 2, 3, and 4 of THMs were 1.5 (0.7-3.5), 3.4 (1.4-8.2), and 5.9 (1.8-19.0), respectively.	Trihalomethanes	115-119	glutathione S-transferase zeta 1	Homo sapiens	71-76
19426674-7	2009	Since DCA can inactivate GSTZ1-1 there is a possibility that long-term treatment of patients with DCA could cause GSTZ1-1 deficiency and susceptibility to oxidative stress and phenylalanine/tyrosine-induced WBC loss.	Dichloroacetic Acid	6-9	glutathione S-transferase zeta 1	Homo sapiens	25-32
19426674-7	2009	Since DCA can inactivate GSTZ1-1 there is a possibility that long-term treatment of patients with DCA could cause GSTZ1-1 deficiency and susceptibility to oxidative stress and phenylalanine/tyrosine-induced WBC loss.	Dichloroacetic Acid	98-101	glutathione S-transferase zeta 1	Homo sapiens	25-32
19426674-7	2009	Since DCA can inactivate GSTZ1-1 there is a possibility that long-term treatment of patients with DCA could cause GSTZ1-1 deficiency and susceptibility to oxidative stress and phenylalanine/tyrosine-induced WBC loss.	Phenylalanine	176-189	glutathione S-transferase zeta 1	Homo sapiens	25-32
19426674-7	2009	Since DCA can inactivate GSTZ1-1 there is a possibility that long-term treatment of patients with DCA could cause GSTZ1-1 deficiency and susceptibility to oxidative stress and phenylalanine/tyrosine-induced WBC loss.	Tyrosine	190-198	glutathione S-transferase zeta 1	Homo sapiens	25-32
18824004-10	2008	MPI has significant sequence similarity to maleylacetoacetate isomerase (MAAI), which performs an analogous reaction in the catabolism of phenylalanine and tyrosine.	Phenylalanine	138-151	glutathione S-transferase zeta 1	Homo sapiens	73-77
18824004-10	2008	MPI has significant sequence similarity to maleylacetoacetate isomerase (MAAI), which performs an analogous reaction in the catabolism of phenylalanine and tyrosine.	Tyrosine	156-164	glutathione S-transferase zeta 1	Homo sapiens	43-71
18824004-10	2008	MPI has significant sequence similarity to maleylacetoacetate isomerase (MAAI), which performs an analogous reaction in the catabolism of phenylalanine and tyrosine.	Tyrosine	156-164	glutathione S-transferase zeta 1	Homo sapiens	73-77
18647626-3	2008	DCA is metabolized by and inhibits the bifunctional zeta-1 family isoform of glutathione transferase/maleylacetoacetate isomerase.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	101-129
18776599-9	2008	MDR analysis revealed a three-gene combination, consisting of NOS3 (p.Glu298Asp), GSTZ1 (p.Lys32Glu), and GSTP1 (p.Ile105Val), that provided the highest predictive model for GM-induced vestibular dysfunction (64% accuracy; p=0.009).	Gentamicins	174-176	glutathione S-transferase zeta 1	Homo sapiens	82-87
18096758-2	2008	It is biotransformed principally by the zeta-1 family isoform of glutathione transferase (GSTz1), also known as maleylacetoacetate isomerase (MAAI), which catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	189-197	glutathione S-transferase zeta 1	Homo sapiens	90-95
18096758-2	2008	It is biotransformed principally by the zeta-1 family isoform of glutathione transferase (GSTz1), also known as maleylacetoacetate isomerase (MAAI), which catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	189-197	glutathione S-transferase zeta 1	Homo sapiens	112-140
18096758-2	2008	It is biotransformed principally by the zeta-1 family isoform of glutathione transferase (GSTz1), also known as maleylacetoacetate isomerase (MAAI), which catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	189-197	glutathione S-transferase zeta 1	Homo sapiens	142-146
18096758-11	2008	Hepatic GSTz1/MAAI-specific activity was inhibited equally by DCA treatment among all age groups, whereas plasma and urinary levels of maleylacetone, a natural substrate for this enzyme, increased with age.	Dichloroacetic Acid	62-65	glutathione S-transferase zeta 1	Homo sapiens	8-13
18096758-11	2008	Hepatic GSTz1/MAAI-specific activity was inhibited equally by DCA treatment among all age groups, whereas plasma and urinary levels of maleylacetone, a natural substrate for this enzyme, increased with age.	Dichloroacetic Acid	62-65	glutathione S-transferase zeta 1	Homo sapiens	14-18
18373941-5	2008	In this study, we have taken advantage of a new scaffold, hGSTZ1-1, in which there are two serine residues in the active site, to achieve both high thiol selectivity and highly catalytic efficiency.	Serine	91-97	glutathione S-transferase zeta 1	Homo sapiens	58-66
18373941-5	2008	In this study, we have taken advantage of a new scaffold, hGSTZ1-1, in which there are two serine residues in the active site, to achieve both high thiol selectivity and highly catalytic efficiency.	Sulfhydryl Compounds	148-153	glutathione S-transferase zeta 1	Homo sapiens	58-66
18373941-6	2008	The GPX activity of Se-hGSTZ1-1 is about 1.5 times that of rabbit liver GPX, indicating that the selenium content at the active site plays an important role in enhancement of catalytic performance.	Selenium	97-105	glutathione S-transferase zeta 1	Homo sapiens	23-31
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	Glutathione	27-38	glutathione S-transferase zeta 1	Homo sapiens	51-58
17966553-5	2007	Because of the bad prognosis of this histologic type, the patient received adjuvant chemotherapy: a combination of doxorubicin and ifosfamide (MAI).	Ifosfamide	131-141	glutathione S-transferase zeta 1	Homo sapiens	143-146
16461014-11	2006	GSTZ1C based enzyme kinetic studies has low affinity for fluoroacetate.	Fluoroacetates	57-70	glutathione S-transferase zeta 1	Homo sapiens	0-5
16461014-12	2006	The evidence suggests that GSTZ1 may not be the major enzyme defluorinating fluoroacetate, but it does detoxify the fluoroacetate.	Fluoroacetates	76-89	glutathione S-transferase zeta 1	Homo sapiens	27-32
16461014-12	2006	The evidence suggests that GSTZ1 may not be the major enzyme defluorinating fluoroacetate, but it does detoxify the fluoroacetate.	Fluoroacetates	116-129	glutathione S-transferase zeta 1	Homo sapiens	27-32
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	maleylacetoacetate	112-130	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	fumarylacetoacetate	134-153	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	Tyrosine	161-169	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	alpha-halo acids	217-233	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	Dichloroacetic Acid	245-264	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-1	2006	OBJECTIVES: The zeta-class glutathione transferase GSTZ1-1 catalyses the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate in the tyrosine catabolic pathway and the biotransformation of alpha-halo acids, including dichloroacetic acid (DCA).	Dichloroacetic Acid	266-269	glutathione S-transferase zeta 1	Homo sapiens	51-58
16609361-9	2006	CONCLUSION: These SNPs may alter GSTZ1 expression, which may alter the pharmacokinetics of DCA, which is used therapeutically for the treatment of lactic acidosis.	Dichloroacetic Acid	91-94	glutathione S-transferase zeta 1	Homo sapiens	33-38
17162865-4	2005	Subconjunctiva injection of 5-Fu and Triamcinolone treat MAI in therapeutic group.	Fluorouracil	28-32	glutathione S-transferase zeta 1	Homo sapiens	57-60
17162865-4	2005	Subconjunctiva injection of 5-Fu and Triamcinolone treat MAI in therapeutic group.	Triamcinolone	37-50	glutathione S-transferase zeta 1	Homo sapiens	57-60
17162865-5	2005	And that of Dexamethasone treat MAI in control group.	Dexamethasone	12-25	glutathione S-transferase zeta 1	Homo sapiens	32-35
17162865-9	2005	CONCLUSION: The therapy of 5-Fu and Triamcinolone to treat the MAI after traumatic cataract surgery is safe and effective.	Fluorouracil	27-31	glutathione S-transferase zeta 1	Homo sapiens	63-66
17162865-9	2005	CONCLUSION: The therapy of 5-Fu and Triamcinolone to treat the MAI after traumatic cataract surgery is safe and effective.	Triamcinolone	36-49	glutathione S-transferase zeta 1	Homo sapiens	63-66
12852784-1	2003	hGSTZ1-1 (human glutathione transferase Zeta 1-1) catalyses a range of glutathione-dependent reactions and plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity.	Glutathione	16-27	glutathione S-transferase zeta 1	Homo sapiens	0-8
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	109-116
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	gstz	53-57	glutathione S-transferase zeta 1	Homo sapiens	109-116
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	Cysteine	93-96	glutathione S-transferase zeta 1	Homo sapiens	109-116
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	Glutathione	181-192	glutathione S-transferase zeta 1	Homo sapiens	109-116
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	Carbon	201-207	glutathione S-transferase zeta 1	Homo sapiens	109-116
16399379-7	2005	DCA was found to be a mechanism-based inactivator of GSTZ, and proteomic studies showed that Cys-16 of human GSTZ1-1 is covalently modified by a reactive intermediate that contains glutathione and the carbon skeleton of DCA.	Dichloroacetic Acid	220-223	glutathione S-transferase zeta 1	Homo sapiens	109-116
12852784-1	2003	hGSTZ1-1 (human glutathione transferase Zeta 1-1) catalyses a range of glutathione-dependent reactions and plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity.	Glutathione	16-27	glutathione S-transferase zeta 1	Homo sapiens	169-197
12852784-1	2003	hGSTZ1-1 (human glutathione transferase Zeta 1-1) catalyses a range of glutathione-dependent reactions and plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity.	Tyrosine	152-160	glutathione S-transferase zeta 1	Homo sapiens	0-8
12852784-1	2003	hGSTZ1-1 (human glutathione transferase Zeta 1-1) catalyses a range of glutathione-dependent reactions and plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity.	Tyrosine	152-160	glutathione S-transferase zeta 1	Homo sapiens	16-48
12852784-1	2003	hGSTZ1-1 (human glutathione transferase Zeta 1-1) catalyses a range of glutathione-dependent reactions and plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity.	Tyrosine	152-160	glutathione S-transferase zeta 1	Homo sapiens	169-197
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Serine	152-155	glutathione S-transferase zeta 1	Homo sapiens	48-54
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Serine	152-155	glutathione S-transferase zeta 1	Homo sapiens	66-70
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Serine	160-163	glutathione S-transferase zeta 1	Homo sapiens	48-54
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Serine	160-163	glutathione S-transferase zeta 1	Homo sapiens	66-70
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Cysteine	168-171	glutathione S-transferase zeta 1	Homo sapiens	48-54
12852784-2	2003	The crystal structure and sequence alignment of hGSTZ1 with other GSTs (glutathione transferases) focused attention on three highly conserved residues (Ser-14, Ser-15, Cys-16) as candidates for an important role in catalysis.	Cysteine	168-171	glutathione S-transferase zeta 1	Homo sapiens	66-70
12852784-9	2003	Previous structural studies implicated Arg-175 in the orientation of alpha-halo acid substrates in the active site of hGSTZ1-1.	Arginine	39-42	glutathione S-transferase zeta 1	Homo sapiens	118-126
12852784-9	2003	Previous structural studies implicated Arg-175 in the orientation of alpha-halo acid substrates in the active site of hGSTZ1-1.	alpha-halo acid	69-84	glutathione S-transferase zeta 1	Homo sapiens	118-126
12018993-0	2002	Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.	maleylacetone	80-93	glutathione S-transferase zeta 1	Homo sapiens	67-75
12437329-2	2002	GSTZ1-1 catalyzes the cis-trans isomerization of maleylacetoacetate to fumarylacetoacetate and the biotransformation of a range of alpha-haloalkanoic acids.	maleylacetoacetate	49-67	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-2	2002	GSTZ1-1 catalyzes the cis-trans isomerization of maleylacetoacetate to fumarylacetoacetate and the biotransformation of a range of alpha-haloalkanoic acids.	fumarylacetoacetate	71-90	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-2	2002	GSTZ1-1 catalyzes the cis-trans isomerization of maleylacetoacetate to fumarylacetoacetate and the biotransformation of a range of alpha-haloalkanoic acids.	alpha-haloalkanoic acids	131-155	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-3	2002	GSTZ1-1-catalyzed biotransformation of fluorine-lacking alpha,alpha-dihaloalkanoic acids, including dichloroacetic acid (DCA), results in the mechanism-based inactivation and covalent modification of the enzyme.	Fluorine	39-47	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-3	2002	GSTZ1-1-catalyzed biotransformation of fluorine-lacking alpha,alpha-dihaloalkanoic acids, including dichloroacetic acid (DCA), results in the mechanism-based inactivation and covalent modification of the enzyme.	alpha,alpha-dihaloalkanoic acids	56-88	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-3	2002	GSTZ1-1-catalyzed biotransformation of fluorine-lacking alpha,alpha-dihaloalkanoic acids, including dichloroacetic acid (DCA), results in the mechanism-based inactivation and covalent modification of the enzyme.	Dichloroacetic Acid	100-119	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-3	2002	GSTZ1-1-catalyzed biotransformation of fluorine-lacking alpha,alpha-dihaloalkanoic acids, including dichloroacetic acid (DCA), results in the mechanism-based inactivation and covalent modification of the enzyme.	Dichloroacetic Acid	121-124	glutathione S-transferase zeta 1	Homo sapiens	0-7
12437329-12	2002	These findings explain the DCA-induced inactivation of GSTZ1-1 observed in humans and rats.	Dichloroacetic Acid	27-30	glutathione S-transferase zeta 1	Homo sapiens	55-62
12119007-0	2002	Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).	maleylacetone	37-50	glutathione S-transferase zeta 1	Homo sapiens	142-150
12119007-0	2002	Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).	chlorofluoroacetic acid	55-78	glutathione S-transferase zeta 1	Homo sapiens	142-150
12119007-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate and the biotransformation of a range of alpha-haloacids.	maleylacetoacetate	80-98	glutathione S-transferase zeta 1	Homo sapiens	30-37
12119007-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate and the biotransformation of a range of alpha-haloacids.	alpha-haloacids	139-154	glutathione S-transferase zeta 1	Homo sapiens	30-37
12119007-2	2002	The objective of this study was to determine the kinetics of the biotransformation of maleylacetone (MA), an analogue of the natural substrate maleylacetoacetate, and chlorofluoroacetic acid (CFA) by polymorphic variants of recombinant hGSTZ1-1.	maleylacetone	86-99	glutathione S-transferase zeta 1	Homo sapiens	236-244
12119007-2	2002	The objective of this study was to determine the kinetics of the biotransformation of maleylacetone (MA), an analogue of the natural substrate maleylacetoacetate, and chlorofluoroacetic acid (CFA) by polymorphic variants of recombinant hGSTZ1-1.	chlorofluoroacetic acid	167-190	glutathione S-transferase zeta 1	Homo sapiens	236-244
12119007-2	2002	The objective of this study was to determine the kinetics of the biotransformation of maleylacetone (MA), an analogue of the natural substrate maleylacetoacetate, and chlorofluoroacetic acid (CFA) by polymorphic variants of recombinant hGSTZ1-1.	chlorofluoroacetic acid	192-195	glutathione S-transferase zeta 1	Homo sapiens	236-244
12052898-2	2002	There are well-described human diseases associated with deficiencies of all enzymes in this pathway except for maleylacetoacetate isomerase (MAAI), which converts maleylacetoacetate (MAA) to fumarylacetoacetate (FAA).	maleylacetoacetate	111-129	glutathione S-transferase zeta 1	Homo sapiens	141-145
12052898-2	2002	There are well-described human diseases associated with deficiencies of all enzymes in this pathway except for maleylacetoacetate isomerase (MAAI), which converts maleylacetoacetate (MAA) to fumarylacetoacetate (FAA).	maa	141-144	glutathione S-transferase zeta 1	Homo sapiens	111-139
12052898-2	2002	There are well-described human diseases associated with deficiencies of all enzymes in this pathway except for maleylacetoacetate isomerase (MAAI), which converts maleylacetoacetate (MAA) to fumarylacetoacetate (FAA).	fumarylacetoacetate	191-210	glutathione S-transferase zeta 1	Homo sapiens	111-139
12052898-2	2002	There are well-described human diseases associated with deficiencies of all enzymes in this pathway except for maleylacetoacetate isomerase (MAAI), which converts maleylacetoacetate (MAA) to fumarylacetoacetate (FAA).	fumarylacetoacetate	191-210	glutathione S-transferase zeta 1	Homo sapiens	141-145
12018993-0	2002	Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.	fumarylacetone	98-112	glutathione S-transferase zeta 1	Homo sapiens	67-75
12018993-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate or maleylacetone (MA) to fumarylacetoacetate or fumarylacetone (FA), respectively.	maleylacetoacetate	80-98	glutathione S-transferase zeta 1	Homo sapiens	30-37
12018993-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate or maleylacetone (MA) to fumarylacetoacetate or fumarylacetone (FA), respectively.	maleylacetone	102-115	glutathione S-transferase zeta 1	Homo sapiens	30-37
12018993-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate or maleylacetone (MA) to fumarylacetoacetate or fumarylacetone (FA), respectively.	fumarylacetoacetate	124-143	glutathione S-transferase zeta 1	Homo sapiens	30-37
12018993-1	2002	Glutathione transferase zeta (GSTZ1-1) catalyzes the cis-trans isomerization of maleylacetoacetate or maleylacetone (MA) to fumarylacetoacetate or fumarylacetone (FA), respectively.	fumarylacetone	147-161	glutathione S-transferase zeta 1	Homo sapiens	30-37
12018993-2	2002	GSTZ1-1 also catalyzes the glutathione-dependent biotransformation of a range of alpha-haloacids, including dichloroacetic acid.	Glutathione	27-38	glutathione S-transferase zeta 1	Homo sapiens	0-7
12018993-2	2002	GSTZ1-1 also catalyzes the glutathione-dependent biotransformation of a range of alpha-haloacids, including dichloroacetic acid.	alpha-haloacids	81-96	glutathione S-transferase zeta 1	Homo sapiens	0-7
12018993-2	2002	GSTZ1-1 also catalyzes the glutathione-dependent biotransformation of a range of alpha-haloacids, including dichloroacetic acid.	Dichloroacetic Acid	108-127	glutathione S-transferase zeta 1	Homo sapiens	0-7
12018993-4	2002	MA and FA (0.01-1 mM) inactivated all hGSTZ1-1 polymorphic variants in a concentration- and time-dependent manner, and this inactivation was blocked by glutathione.	Glutathione	152-163	glutathione S-transferase zeta 1	Homo sapiens	38-46
12018993-6	2002	Electrospray ionization-tandem mass spectrometry and SALSA (Scoring Algorithm for Spectral Analysis) analyses of tryptic digests of hGSTZ1 polymorphic variants revealed that the active site (SSCSWR) and C-terminal (LLVLEAFQVSHPCR) cysteine residues of hGSTZ1-1 were covalently modified by MA and FA.	Cysteine	231-239	glutathione S-transferase zeta 1	Homo sapiens	132-138
12018993-8	2002	Alkylation of the active-site cysteine residues, but not of the C-terminal cysteine, was relatively less intense when hGSTZ1-1 polymorphic variants were incubated with MA or FA in the presence of S-methyl glutathione.	Cysteine	30-38	glutathione S-transferase zeta 1	Homo sapiens	118-126
12018993-8	2002	Alkylation of the active-site cysteine residues, but not of the C-terminal cysteine, was relatively less intense when hGSTZ1-1 polymorphic variants were incubated with MA or FA in the presence of S-methyl glutathione.	S-methyl glutathione	196-216	glutathione S-transferase zeta 1	Homo sapiens	118-126
12018993-9	2002	These data indicate that MA and FA are substrate and product inactivators of hGSTZ1-1 and covalently modify hGSTZ1-1 at the active-site cysteine residue in the absence of glutathione.	Cysteine	136-144	glutathione S-transferase zeta 1	Homo sapiens	108-116
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	maleylacetoacetate	90-108	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	maa	110-113	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	fumarylacetoacetate	118-137	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	fumarylacetoacetate	139-142	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	Dichloroacetic Acid	174-193	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-1	2001	The zeta class glutathione transferases (GSTs) are known to catalyse the isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA), and the biotransformation of dichloroacetic acid to glyoxylate.	glyoxylic acid	197-207	glutathione S-transferase zeta 1	Homo sapiens	41-45
11692075-6	2001	The maleylacetoacetate isomerase (MAAI) activity of all known variants was compared using maleylacetone as a substrate.	maleylacetone	90-103	glutathione S-transferase zeta 1	Homo sapiens	4-32
11692075-6	2001	The maleylacetoacetate isomerase (MAAI) activity of all known variants was compared using maleylacetone as a substrate.	maleylacetone	90-103	glutathione S-transferase zeta 1	Homo sapiens	34-38
10775321-7	2000	The k(inact) values for the dichloroacetate-induced inactivation of four polymorphic variants of recombinant human glutathione transferase zeta (hGSTZ1-1) were in the following order: variant 1a-1a < 1b-1b approximately 1c-1c approximately 1d-1d.	Dichloroacetic Acid	28-43	glutathione S-transferase zeta 1	Homo sapiens	145-153
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Phenylalanine	82-95	glutathione S-transferase zeta 1	Homo sapiens	0-28
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Phenylalanine	82-95	glutathione S-transferase zeta 1	Homo sapiens	30-34
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Tyrosine	100-108	glutathione S-transferase zeta 1	Homo sapiens	0-28
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Tyrosine	100-108	glutathione S-transferase zeta 1	Homo sapiens	30-34
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Glutathione	124-135	glutathione S-transferase zeta 1	Homo sapiens	0-28
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	Glutathione	124-135	glutathione S-transferase zeta 1	Homo sapiens	30-34
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	maleylacetoacetate	163-181	glutathione S-transferase zeta 1	Homo sapiens	0-28
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	maleylacetoacetate	163-181	glutathione S-transferase zeta 1	Homo sapiens	30-34
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	fumarylacetoacetate	185-204	glutathione S-transferase zeta 1	Homo sapiens	0-28
11327815-1	2001	Maleylacetoacetate isomerase (MAAI), a key enzyme in the metabolic degradation of phenylalanine and tyrosine, catalyzes the glutathione-dependent isomerization of maleylacetoacetate to fumarylacetoacetate.	fumarylacetoacetate	185-204	glutathione S-transferase zeta 1	Homo sapiens	30-34
11327815-4	2001	Here we report the crystal structure of human MAAI at 1.9 A resolution in complex with glutathione and a sulfate ion which mimics substrate binding.	Glutathione	87-98	glutathione S-transferase zeta 1	Homo sapiens	46-50
11327815-4	2001	Here we report the crystal structure of human MAAI at 1.9 A resolution in complex with glutathione and a sulfate ion which mimics substrate binding.	Sulfates	105-112	glutathione S-transferase zeta 1	Homo sapiens	46-50
11764965-0	2001	Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.	maleylacetone	89-102	glutathione S-transferase zeta 1	Homo sapiens	76-84
11764965-0	2001	Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.	fumarylacetone	107-121	glutathione S-transferase zeta 1	Homo sapiens	76-84
10775321-8	2000	The dichloroacetate-induced inactivation of hGSTZ1-1 was irreversible.	Dichloroacetic Acid	4-19	glutathione S-transferase zeta 1	Homo sapiens	44-52
9396740-3	1997	An atomic model of the N-terminal domain suggests that the members of the Zeta class have a similar structure to that of other GSTs, binding glutathione in a similar orientation in the G site.	Glutathione	141-152	glutathione S-transferase zeta 1	Homo sapiens	127-131
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	gstz	0-4	glutathione S-transferase zeta 1	Homo sapiens	21-49
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	Tyrosine	64-72	glutathione S-transferase zeta 1	Homo sapiens	21-49
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	maa	118-121	glutathione S-transferase zeta 1	Homo sapiens	21-49
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	fumarylacetoacetate	126-145	glutathione S-transferase zeta 1	Homo sapiens	21-49
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	maleylacetone	150-163	glutathione S-transferase zeta 1	Homo sapiens	21-49
10471397-2	1999	GSTz is identical to maleylacetoacetate isomerase, an enzyme of tyrosine catabolism that converts maleylacetoacetate (MAA) to fumarylacetoacetate and maleylacetone (MA) to fumarylacetone.	fumarylacetone	172-186	glutathione S-transferase zeta 1	Homo sapiens	21-49
9417084-3	1998	We use here an identical approach to characterize at the cDNA level the human gene for maleylacetoacetate isomerase (MAAI, EC 5.2.1.2), the only as yet unidentified structural gene of the phenylalanine catabolic pathway.	Phenylalanine	188-201	glutathione S-transferase zeta 1	Homo sapiens	87-115
9417084-3	1998	We use here an identical approach to characterize at the cDNA level the human gene for maleylacetoacetate isomerase (MAAI, EC 5.2.1.2), the only as yet unidentified structural gene of the phenylalanine catabolic pathway.	Phenylalanine	188-201	glutathione S-transferase zeta 1	Homo sapiens	117-121
9925947-3	1998	This cDNA has also been described as maleylacetoacetate isomerase (MAAI), an enzyme of the phenylalanine catabolism pathway (Fernandez-Canon and Penalva, 1998).	Phenylalanine	91-104	glutathione S-transferase zeta 1	Homo sapiens	37-65
9925947-3	1998	This cDNA has also been described as maleylacetoacetate isomerase (MAAI), an enzyme of the phenylalanine catabolism pathway (Fernandez-Canon and Penalva, 1998).	Phenylalanine	91-104	glutathione S-transferase zeta 1	Homo sapiens	67-71
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32-->Glu and Arg-42--> Gly substitutions.	Lysine	111-114	glutathione S-transferase zeta 1	Homo sapiens	48-53
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32-->Glu and Arg-42--> Gly substitutions.	Glutamic Acid	123-126	glutathione S-transferase zeta 1	Homo sapiens	48-53
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32-->Glu and Arg-42--> Gly substitutions.	Arginine	131-134	glutathione S-transferase zeta 1	Homo sapiens	48-53
9925947-8	1998	The coding region of the gene differed from the GSTZ1 cDNA at two nucleotide positions in exon 3, resulting in Lys-32-->Glu and Arg-42--> Gly substitutions.	Glycine	144-147	glutathione S-transferase zeta 1	Homo sapiens	48-53
9396740-6	1997	Although low in comparison with other GSTs, GSTZ1-1 has glutathione peroxidase activity with t-butyl and cumene hydroperoxides.	t-butyl and cumene hydroperoxides	93-126	glutathione S-transferase zeta 1	Homo sapiens	44-51
8334346-7	1993	Among patients of group B, preceding Sheng Mai injection was glucose.	Glucose	61-68	glutathione S-transferase zeta 1	Homo sapiens	43-46
32507125-11	2020	: The results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and in oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence.	Glutamic Acid	45-54	glutathione S-transferase zeta 1	Homo sapiens	96-101
35562974-9	2022	In summary, we identified the tyrosine metabolizing enzymes HGD and GSTZ1 as biomarkers of KIRC, which will further the understanding of the tumor metabolism profile, provide novel strategies and theoretical support for diagnosing and treating KIRC and as referential for future clinical research.	Tyrosine	30-38	glutathione S-transferase zeta 1	Homo sapiens	68-73
5142161-0	1971	[Lung scintigraphy with macro-aggregate of radioactive iodine labelled human serum albumin (MAAI-131)].	radioactive iodine	43-61	glutathione S-transferase zeta 1	Homo sapiens	92-96
5633741-1	1967	Study with I-131 labelled albumin macroaggregates (MAAI 131)].	Iodine-131	11-16	glutathione S-transferase zeta 1	Homo sapiens	51-55
32357971-1	2020	Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age seven.	Tyrosine	113-121	glutathione S-transferase zeta 1	Homo sapiens	53-83
32357971-1	2020	Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age seven.	Tyrosine	113-121	glutathione S-transferase zeta 1	Homo sapiens	85-90
32357971-1	2020	Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age seven.	Dichloroacetic Acid	192-207	glutathione S-transferase zeta 1	Homo sapiens	53-83
32357971-1	2020	Previous work has shown that hepatic levels of human glutathione transferase zeta 1 (GSTZ1) protein, involved in tyrosine catabolism and responsible for metabolism of the investigational drug dichloroacetate, increase in cytosol after birth before reaching a plateau around age seven.	Dichloroacetic Acid	192-207	glutathione S-transferase zeta 1	Homo sapiens	85-90
32357971-8	2020	Our findings suggest that miR-376c-3p prevents production of GSTZ1 through inhibition of translation.	mir-376c-3p	26-37	glutathione S-transferase zeta 1	Homo sapiens	61-66
32357971-11	2020	SIGNIFICANCE STATEMENT: Hepatic GSTZ1 is responsible for metabolism of the tyrosine catabolite maleylacetoacetate as well as the investigational drug dichloroacetate.	Tyrosine	75-83	glutathione S-transferase zeta 1	Homo sapiens	32-37
32357971-11	2020	SIGNIFICANCE STATEMENT: Hepatic GSTZ1 is responsible for metabolism of the tyrosine catabolite maleylacetoacetate as well as the investigational drug dichloroacetate.	maleylacetoacetate	95-113	glutathione S-transferase zeta 1	Homo sapiens	32-37
32357971-11	2020	SIGNIFICANCE STATEMENT: Hepatic GSTZ1 is responsible for metabolism of the tyrosine catabolite maleylacetoacetate as well as the investigational drug dichloroacetate.	Dichloroacetic Acid	150-165	glutathione S-transferase zeta 1	Homo sapiens	32-37
32873592-3	2020	Repetitive DCA dosing causes downregulation of its metabolizing enzyme, GSTZ1, which is also critical in the detoxification of maleylacetoacetate and maleylacetone.	Dichloroacetic Acid	11-14	glutathione S-transferase zeta 1	Homo sapiens	72-77
32873592-3	2020	Repetitive DCA dosing causes downregulation of its metabolizing enzyme, GSTZ1, which is also critical in the detoxification of maleylacetoacetate and maleylacetone.	maleylacetoacetate	127-145	glutathione S-transferase zeta 1	Homo sapiens	72-77
32873592-3	2020	Repetitive DCA dosing causes downregulation of its metabolizing enzyme, GSTZ1, which is also critical in the detoxification of maleylacetoacetate and maleylacetone.	maleylacetone	150-163	glutathione S-transferase zeta 1	Homo sapiens	72-77
32507125-11	2020	: The results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and in oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence.	Glutathione	65-76	glutathione S-transferase zeta 1	Homo sapiens	96-101
31782257-1	2020	Glutathione S-transferase Zeta 1-1(GSTZ1-1), an enzyme involved in the catabolism of phenylalanine and the detoxification of xenobiotics, plays a tumour suppressor role in hepatocellular carcinoma (HCC), but the underlying mechanism remains largely unknown.	leucyl-phenylalanine	85-98	glutathione S-transferase zeta 1	Homo sapiens	0-42
31624634-0	2019	GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.	Dichloroacetic Acid	31-46	glutathione S-transferase zeta 1	Homo sapiens	0-5
31666108-1	2019	BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism.	leucyl-phenylalanine	82-95	glutathione S-transferase zeta 1	Homo sapiens	12-44
31666108-1	2019	BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism.	leucyl-phenylalanine	82-95	glutathione S-transferase zeta 1	Homo sapiens	46-51
31666108-1	2019	BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism.	Tyrosine	96-104	glutathione S-transferase zeta 1	Homo sapiens	12-44
31666108-1	2019	BACKGROUND: Glutathione S-transferase zeta 1 (GSTZ1) is the penultimate enzyme in phenylalanine/tyrosine catabolism.	Tyrosine	96-104	glutathione S-transferase zeta 1	Homo sapiens	46-51
31666108-10	2019	Moreover, loss of GSTZ1 function depleted GSH, increased ROS levels, and enhanced lipid peroxidation, thus activating the NRF2-mediated antioxidant pathway.	Glutathione	42-45	glutathione S-transferase zeta 1	Homo sapiens	18-23
31666108-12	2019	Furthermore, the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of Gstz1-knockout HepG2 cells and HCC progression in Gstz1-/- mice.	Acetylcysteine	35-51	glutathione S-transferase zeta 1	Homo sapiens	117-122
31666108-12	2019	Furthermore, the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of Gstz1-knockout HepG2 cells and HCC progression in Gstz1-/- mice.	Acetylcysteine	35-51	glutathione S-transferase zeta 1	Homo sapiens	167-172
31666108-12	2019	Furthermore, the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of Gstz1-knockout HepG2 cells and HCC progression in Gstz1-/- mice.	brusatol	71-79	glutathione S-transferase zeta 1	Homo sapiens	117-122
31666108-12	2019	Furthermore, the antioxidant agent N-acetylcysteine and NRF2 inhibitor brusatol effectively suppressed the growth of Gstz1-knockout HepG2 cells and HCC progression in Gstz1-/- mice.	brusatol	71-79	glutathione S-transferase zeta 1	Homo sapiens	167-172
31666108-14	2019	GSH depletion caused by GSTZ1 deficiency elevates oxidative stress, thus constitutively activating the NRF2 antioxidant response pathway and accelerating HCC progression.	Glutathione	0-3	glutathione S-transferase zeta 1	Homo sapiens	24-29
31525872-8	2019	Interaction analyses showed that maternal urinary TCAA in association with decreased birth weight was observed only among subjects with CYP2E1 rs3813867 GC/CC vs. GG (Pint = 0.07) and associations with decreased birth length, ponderal index, and gestational age were observed only among subjects with GSTZ1 rs7975 GA/AA vs. GG (Pint = 0.07, 0.02, and 0.02, respectively).	Trichloroacetic Acid	50-54	glutathione S-transferase zeta 1	Homo sapiens	301-306
31624634-3	2019	GSTZ1 is also irreversibly inactivated by DCA.	Dichloroacetic Acid	42-45	glutathione S-transferase zeta 1	Homo sapiens	0-5
31624634-11	2019	The initial half-life of DCA was shorter in two patients, correlating with heterozygosity for GSTZ1*A genotype, a high enzyme activity variant.	Dichloroacetic Acid	25-28	glutathione S-transferase zeta 1	Homo sapiens	94-99
31624634-12	2019	Over 3 months, one patient maintained DCA trough concentrations approximately threefold higher than other patients, which correlated with a low activity promoter genotype (-1002A, rs7160195) for GSTZ1.	Dichloroacetic Acid	38-41	glutathione S-transferase zeta 1	Homo sapiens	195-200
31624634-15	2019	Promoter GSTZ1 polymorphisms may be important determinants of DCA concentrations and neuropathy during chronic treatment.	Dichloroacetic Acid	62-65	glutathione S-transferase zeta 1	Homo sapiens	9-14
29875071-9	2018	Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.	haloacetic acids	140-156	glutathione S-transferase zeta 1	Homo sapiens	180-185
31267557-3	2019	Here, we revealed that GSTZ1-1, the enzyme in phenylalanine/tyrosine catabolism, is downregulated in HCC, and its expression was negatively correlated with IGF1R.	Phenylalanine	46-59	glutathione S-transferase zeta 1	Homo sapiens	23-30
31267557-3	2019	Here, we revealed that GSTZ1-1, the enzyme in phenylalanine/tyrosine catabolism, is downregulated in HCC, and its expression was negatively correlated with IGF1R.	Tyrosine	60-68	glutathione S-transferase zeta 1	Homo sapiens	23-30
30931449-2	2019	In this work, we demonstrate a facile way to improve the quality of perovskite films by using a MAI/IPA solution to post-treat the perovskite material after the film formation.	perovskite	68-78	glutathione S-transferase zeta 1	Homo sapiens	96-99
30931449-2	2019	In this work, we demonstrate a facile way to improve the quality of perovskite films by using a MAI/IPA solution to post-treat the perovskite material after the film formation.	perovskite	131-141	glutathione S-transferase zeta 1	Homo sapiens	96-99
30931449-6	2019	The results show that the MAI/IPA solution post-treatment after the perovskite film formation is a facile way to improve the film quality and the PSC performance.	perovskite	68-78	glutathione S-transferase zeta 1	Homo sapiens	26-29
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Glutathione	48-59	glutathione S-transferase zeta 1	Homo sapiens	0-29
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Glutathione	48-59	glutathione S-transferase zeta 1	Homo sapiens	31-36
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Glutathione	61-64	glutathione S-transferase zeta 1	Homo sapiens	0-29
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Glutathione	61-64	glutathione S-transferase zeta 1	Homo sapiens	31-36
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Dichloroacetic Acid	94-109	glutathione S-transferase zeta 1	Homo sapiens	0-29
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Dichloroacetic Acid	94-109	glutathione S-transferase zeta 1	Homo sapiens	31-36
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Dichloroacetic Acid	111-114	glutathione S-transferase zeta 1	Homo sapiens	0-29
29853471-1	2018	Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer.	Dichloroacetic Acid	111-114	glutathione S-transferase zeta 1	Homo sapiens	31-36
29853471-4	2018	GSTZ1 expression and activity with DCA were determined in 103 human hepatic mitochondrial samples prepared from livers of donors aged 1 day to 84 years.	Dichloroacetic Acid	35-38	glutathione S-transferase zeta 1	Homo sapiens	0-5
29853471-9	2018	In the presence of 38 mM chloride, mitochondrial GSTZ1 exhibited shorter half-lives of inactivation compared with the cytosolic enzyme (P = 0.017).	Chlorides	25-33	glutathione S-transferase zeta 1	Homo sapiens	49-54
29875071-9	2018	Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.	Water	277-282	glutathione S-transferase zeta 1	Homo sapiens	180-185
29154175-0	2018	Improving human health outcomes with a low-cost intervention to reduce exposures from lead acid battery recycling: Dong Mai, Vietnam.	lead acid	86-95	glutathione S-transferase zeta 1	Homo sapiens	120-123
29641284-0	2018	Personalized Dosing of Dichloroacetate Using GSTZ1 Clinical Genotyping Assay.	Dichloroacetic Acid	23-38	glutathione S-transferase zeta 1	Homo sapiens	45-50
29641284-1	2018	AIMS: Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	6-21	glutathione S-transferase zeta 1	Homo sapiens	134-163
29641284-1	2018	AIMS: Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	6-21	glutathione S-transferase zeta 1	Homo sapiens	165-170
29641284-1	2018	AIMS: Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	23-26	glutathione S-transferase zeta 1	Homo sapiens	134-163
29641284-1	2018	AIMS: Dichloroacetate (DCA) represents the first targeted therapy for pyruvate dehydrogenase complex deficiency; it is metabolized by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	23-26	glutathione S-transferase zeta 1	Homo sapiens	165-170
29641284-2	2018	Variation in the GSTZ1 haplotype is the principal variable influencing DCA kinetics and dynamics in humans.	Dichloroacetic Acid	71-74	glutathione S-transferase zeta 1	Homo sapiens	17-22
29641284-3	2018	We aimed to develop a sensitive and rapid clinical genetic screening test for determining GSTZ1 haplotype status in individuals who would be treated with DCA, and then apply the test for the investigation of the plasma pharmacokinetics (PK) of DCA as a function of GSTZ1 haplotype.	Dichloroacetic Acid	154-157	glutathione S-transferase zeta 1	Homo sapiens	90-95
28914978-6	2018	A 2-compartment model accounting for saturable clearance and GSTZ1 enzyme turnover successfully characterized the DCA PK in adults and children.	Dichloroacetic Acid	114-117	glutathione S-transferase zeta 1	Homo sapiens	61-66
28914978-7	2018	DCA-induced inactivation of GSTZ1 resulted in phenoconversion of all subjects into slow metabolizers after repeated dosing.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	28-33
28914978-8	2018	However, rate and extent of inactivation was 2-fold higher in subjects without the wild-type EGT allelic variant of GSTZ1, resulting in further phenoconversion into ultraslow metabolizers after repeated DCA administration.	Dichloroacetic Acid	203-206	glutathione S-transferase zeta 1	Homo sapiens	116-121
28914978-9	2018	Furthermore, DCA-induced GSTZ1 inactivation rate and extent was found to be 25- to 30-fold lower in children than in adults, potentially accounting for the observed age-dependent changes in PK.	Dichloroacetic Acid	13-16	glutathione S-transferase zeta 1	Homo sapiens	25-30
26970898-1	2016	Trihalomethanes (THMs) have been reported to be associated with altered semen quality, and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTZ1 and GSTT1), which metabolize THMs.	Trihalomethanes	0-15	glutathione S-transferase zeta 1	Homo sapiens	208-213
29326876-10	2018	All newborns identified with mild hypersuccinylacetonemia in Quebec have had genetic deficiencies of tyrosine degradation: either deficiency of the enzyme preceding FAH, maleylacetoacetate isomerase, or partial deficiency of FAH itself.	Tyrosine	101-109	glutathione S-transferase zeta 1	Homo sapiens	170-198
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	Dichloroacetic Acid	18-21	glutathione S-transferase zeta 1	Homo sapiens	74-104
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	Dichloroacetic Acid	18-21	glutathione S-transferase zeta 1	Homo sapiens	106-111
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	glyoxylic acid	50-60	glutathione S-transferase zeta 1	Homo sapiens	74-104
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	glyoxylic acid	50-60	glutathione S-transferase zeta 1	Homo sapiens	106-111
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	Dichloroacetic Acid	124-127	glutathione S-transferase zeta 1	Homo sapiens	74-104
27771434-6	2017	The first step in DCA metabolism is conversion to glyoxylate catalyzed by glutathione transferase zeta 1 (GSTZ1), for which DCA is a mechanism-based inactivator.	Dichloroacetic Acid	124-127	glutathione S-transferase zeta 1	Homo sapiens	106-111
27771434-7	2017	The rate of GSTZ1 inactivation by DCA is influenced by age, GSTZ1 haplotype and cellular concentrations of chloride.	Dichloroacetic Acid	34-37	glutathione S-transferase zeta 1	Homo sapiens	12-17
27771434-7	2017	The rate of GSTZ1 inactivation by DCA is influenced by age, GSTZ1 haplotype and cellular concentrations of chloride.	Dichloroacetic Acid	34-37	glutathione S-transferase zeta 1	Homo sapiens	60-65
27771434-7	2017	The rate of GSTZ1 inactivation by DCA is influenced by age, GSTZ1 haplotype and cellular concentrations of chloride.	Chlorides	107-115	glutathione S-transferase zeta 1	Homo sapiens	12-17
27197232-10	2016	Tumors exhibited increased antioxidant metabolites and upregulation of glutathione S-transferase pathway genes, including Gstp1 and Gstz1, which are associated with poor outcome in human neuroblastoma.	Glutathione	71-82	glutathione S-transferase zeta 1	Homo sapiens	132-137
28300864-7	2017	Using gene-based association tests of rare and low-frequency variants, we found significant associations of HYAL2 with increased ADP-induced aggregation (p = 1.07x10-7) and GSTZ1 with increased epinephrine-induced aggregation (p = 1.62x10-6).	Epinephrine	194-205	glutathione S-transferase zeta 1	Homo sapiens	173-178
27876694-4	2017	METHODS AND RESULTS: Six newborns referred for hypersuccinylacetonaemia but who had normal coagulation testing on initial evaluation had sequence variants in the GSTZ1 gene, encoding maleylacetoacetate isomerase (MAAI), the enzyme preceding FAH in tyrosine degradation.	Tyrosine	248-256	glutathione S-transferase zeta 1	Homo sapiens	162-167
27876694-4	2017	METHODS AND RESULTS: Six newborns referred for hypersuccinylacetonaemia but who had normal coagulation testing on initial evaluation had sequence variants in the GSTZ1 gene, encoding maleylacetoacetate isomerase (MAAI), the enzyme preceding FAH in tyrosine degradation.	Tyrosine	248-256	glutathione S-transferase zeta 1	Homo sapiens	183-211
27876694-4	2017	METHODS AND RESULTS: Six newborns referred for hypersuccinylacetonaemia but who had normal coagulation testing on initial evaluation had sequence variants in the GSTZ1 gene, encoding maleylacetoacetate isomerase (MAAI), the enzyme preceding FAH in tyrosine degradation.	Tyrosine	248-256	glutathione S-transferase zeta 1	Homo sapiens	213-217
26850694-0	2016	GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate.	Dichloroacetic Acid	85-100	glutathione S-transferase zeta 1	Homo sapiens	0-5
26850694-3	2016	Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein.	Dichloroacetic Acid	113-116	glutathione S-transferase zeta 1	Homo sapiens	32-62
26850694-3	2016	Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein.	Dichloroacetic Acid	113-116	glutathione S-transferase zeta 1	Homo sapiens	64-69
26850694-3	2016	Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein.	glyoxylic acid	145-155	glutathione S-transferase zeta 1	Homo sapiens	32-62
26850694-3	2016	Here we show that expression of glutathione transferase zeta 1 (GSTZ1), the enzyme responsible for conversion of DCA to its inactive metabolite, glyoxylate, is downregulated in liver cancer and upregulated in some breast cancers, leading to abnormal expression of the protein.	glyoxylic acid	145-155	glutathione S-transferase zeta 1	Homo sapiens	64-69
26850694-4	2016	The cellular concentration of chloride, an ion that influences the stability of GSTZ1 in the presence of DCA, was also found to be abnormal in tumors, with consistently higher concentrations in hepatocellular carcinoma than in surrounding non-tumor tissue.	Chlorides	30-38	glutathione S-transferase zeta 1	Homo sapiens	80-85
26850694-4	2016	The cellular concentration of chloride, an ion that influences the stability of GSTZ1 in the presence of DCA, was also found to be abnormal in tumors, with consistently higher concentrations in hepatocellular carcinoma than in surrounding non-tumor tissue.	Dichloroacetic Acid	105-108	glutathione S-transferase zeta 1	Homo sapiens	80-85
26850694-5	2016	Finally, results from experiments employing two- and three-dimensional cultures of HepG2 cells, parental and transduced to express GSTZ1, demonstrate that high levels of GSTZ1 expression confers resistance to the effect of high concentrations of DCA on cell viability.	Dichloroacetic Acid	246-249	glutathione S-transferase zeta 1	Homo sapiens	131-136
26850694-5	2016	Finally, results from experiments employing two- and three-dimensional cultures of HepG2 cells, parental and transduced to express GSTZ1, demonstrate that high levels of GSTZ1 expression confers resistance to the effect of high concentrations of DCA on cell viability.	Dichloroacetic Acid	246-249	glutathione S-transferase zeta 1	Homo sapiens	170-175
26970898-1	2016	Trihalomethanes (THMs) have been reported to be associated with altered semen quality, and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTZ1 and GSTT1), which metabolize THMs.	Trihalomethanes	17-21	glutathione S-transferase zeta 1	Homo sapiens	208-213
26970898-1	2016	Trihalomethanes (THMs) have been reported to be associated with altered semen quality, and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) and glutathione S-transferase (GSTZ1 and GSTT1), which metabolize THMs.	Trihalomethanes	243-247	glutathione S-transferase zeta 1	Homo sapiens	208-213
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	Dichloroacetic Acid	30-33	glutathione S-transferase zeta 1	Homo sapiens	76-106
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	Dichloroacetic Acid	30-33	glutathione S-transferase zeta 1	Homo sapiens	108-115
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	glyoxylic acid	37-47	glutathione S-transferase zeta 1	Homo sapiens	76-106
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	glyoxylic acid	37-47	glutathione S-transferase zeta 1	Homo sapiens	108-115
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	Dichloroacetic Acid	142-145	glutathione S-transferase zeta 1	Homo sapiens	76-106
27143230-4	2016	This is because conversion of DCA to glyoxylate is catalyzed by one enzyme, glutathione transferase zeta 1 (GSTZ1-1), which is inactivated by DCA.	Dichloroacetic Acid	142-145	glutathione S-transferase zeta 1	Homo sapiens	108-115
27143230-5	2016	SNPs in the GSTZ1 gene result in expression of polymorphic variants of the enzyme that differ in activity and rates of inactivation by DCA under physiological conditions: these properties lead to considerable variation between people in the pharmacokinetics of DCA.	Dichloroacetic Acid	135-138	glutathione S-transferase zeta 1	Homo sapiens	12-17
27143230-5	2016	SNPs in the GSTZ1 gene result in expression of polymorphic variants of the enzyme that differ in activity and rates of inactivation by DCA under physiological conditions: these properties lead to considerable variation between people in the pharmacokinetics of DCA.	Dichloroacetic Acid	261-264	glutathione S-transferase zeta 1	Homo sapiens	12-17
26614456-2	2015	Herein, the method was used to estimate the pharmacodynamics of Mai-Luo-Ning injection, a traditional Chinese compound herbal prescription.	ning	72-76	glutathione S-transferase zeta 1	Homo sapiens	64-67
26761626-5	2016	In addition, the gene expression levels of four drug-metabolizing enzymes, two Phase I (CYP1A1, CYP1B1) and two Phase II (GSTM3, GSTZ1) were also increased with the high concentrations of 2DG-MNPs.	Glucosamine	188-191	glutathione S-transferase zeta 1	Homo sapiens	129-134
25640153-7	2015	In multivariate analysis, recent midazolam injection was significantly associated with HIV infection in Chiang Mai (adjusted odds ratio=8.1; 95% confidence interval: 1.2-54.5) whereas in Bangkok HIV status was not associated with recent risk behaviors as infections had likely been acquired in the past.	Midazolam	33-42	glutathione S-transferase zeta 1	Homo sapiens	111-114
25738370-2	2015	Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA.	Dichloroacetic Acid	86-89	glutathione S-transferase zeta 1	Homo sapiens	25-30
25738370-3	2015	DCA metabolism correlates with expression of the GSTZ1 protein, so it is important to document variables that affect expression.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	49-54
25738370-4	2015	Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32>K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.	Lysine	123-129	glutathione S-transferase zeta 1	Homo sapiens	159-164
25738370-4	2015	Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32>K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.	Lysine	123-129	glutathione S-transferase zeta 1	Homo sapiens	247-252
25738370-6	2015	GSTZ1 expression data were analyzed on the basis of the presence or absence of lysine 32.	Lysine	79-85	glutathione S-transferase zeta 1	Homo sapiens	0-5
25738370-10	2015	CONCLUSION: We conclude that the lower expression of GSTZ1 in Whites who possess the K carrier haplotype results in lower enzymatic activity and slower metabolism of DCA, compared with those who possess the non-K carrier haplotype.	Dichloroacetic Acid	166-169	glutathione S-transferase zeta 1	Homo sapiens	53-58
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	30-60
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	62-67
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	92-120
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	122-126
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Tyrosine	155-163	glutathione S-transferase zeta 1	Homo sapiens	30-60
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Tyrosine	155-163	glutathione S-transferase zeta 1	Homo sapiens	62-67
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Tyrosine	155-163	glutathione S-transferase zeta 1	Homo sapiens	92-120
25283137-2	2015	DCA is further metabolized by glutathione transferase zeta 1 (GSTZ1), which is identical to maleylacetoacetate isomerase (MAAI), the penultimate enzyme in tyrosine catabolism.	Tyrosine	155-163	glutathione S-transferase zeta 1	Homo sapiens	122-126
25283137-3	2015	DCA inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone (MA), a metabolite of tyrosine.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	66-71
25283137-3	2015	DCA inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone (MA), a metabolite of tyrosine.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	72-76
25283137-3	2015	DCA inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone (MA), a metabolite of tyrosine.	maleylacetone	195-208	glutathione S-transferase zeta 1	Homo sapiens	66-71
25283137-3	2015	DCA inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone (MA), a metabolite of tyrosine.	Tyrosine	231-239	glutathione S-transferase zeta 1	Homo sapiens	66-71
25283137-3	2015	DCA inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone (MA), a metabolite of tyrosine.	Tyrosine	231-239	glutathione S-transferase zeta 1	Homo sapiens	72-76
25283137-4	2015	It is unknown if GSTZ1/MAAI may participate in the metabolism of CH or any of its metabolites and, therefore, affect tyrosine catabolism.	Tyrosine	117-125	glutathione S-transferase zeta 1	Homo sapiens	23-27
25283137-12	2015	CONCLUSIONS: These data indicate that the amount of DCA produced from clinically relevant doses of CH, although insufficient to alter DCA kinetics, is sufficient to inhibit MAAI and tyrosine catabolism, as evidenced by the accumulation of urinary MA.	Dichloroacetic Acid	52-55	glutathione S-transferase zeta 1	Homo sapiens	173-177
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Dopamine	154-162	glutathione S-transferase zeta 1	Homo sapiens	45-50
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Dopamine	154-162	glutathione S-transferase zeta 1	Homo sapiens	175-180
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Dopamine	220-228	glutathione S-transferase zeta 1	Homo sapiens	45-50
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Dopamine	220-228	glutathione S-transferase zeta 1	Homo sapiens	175-180
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Glutathione	268-279	glutathione S-transferase zeta 1	Homo sapiens	45-50
25675377-13	2015	CONCLUSION: If validated, the involvement of GSTZ1 in cognitive functioning underscores its heritability which is likely the result of differences in the dopamine pathway, as GSTZ1 contributes to the equilibrium between dopamine and its neurotoxic metabolites via the glutathione redox cycle.	Glutathione	268-279	glutathione S-transferase zeta 1	Homo sapiens	175-180
25748576-1	2015	We recently reported that, in a concentration-dependent manner, chloride protects hepatic glutathione transferase zeta 1 from inactivation by dichloroacetate, an investigational drug used in treating various acquired and congenital metabolic diseases.	Chlorides	64-72	glutathione S-transferase zeta 1	Homo sapiens	90-120
25748576-1	2015	We recently reported that, in a concentration-dependent manner, chloride protects hepatic glutathione transferase zeta 1 from inactivation by dichloroacetate, an investigational drug used in treating various acquired and congenital metabolic diseases.	Dichloroacetic Acid	142-157	glutathione S-transferase zeta 1	Homo sapiens	90-120
25748576-4	2015	Because glutathione transferase zeta 1 is present in cytosol and, to a lesser extent, in mitochondria, we measured chloride in these fractions by high-performance liquid chromatography analysis following conversion of the free chloride to pentafluorobenzylchloride.	Chlorides	115-123	glutathione S-transferase zeta 1	Homo sapiens	8-38
25283137-0	2015	Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.	Chloral Hydrate	0-15	glutathione S-transferase zeta 1	Homo sapiens	72-100
25283137-0	2015	Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans.	Dichloroacetic Acid	46-61	glutathione S-transferase zeta 1	Homo sapiens	72-100
25079374-0	2015	Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children.	Dichloroacetic Acid	102-117	glutathione S-transferase zeta 1	Homo sapiens	24-54
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	43-73
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	75-80
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	114-142
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	144-148
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	43-73
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	75-80
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	114-142
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	144-148
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	185-193	glutathione S-transferase zeta 1	Homo sapiens	43-73
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	185-193	glutathione S-transferase zeta 1	Homo sapiens	75-80
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	185-193	glutathione S-transferase zeta 1	Homo sapiens	114-142
25079374-1	2015	Dichloroacetate (DCA) is biotransformed by glutathione transferase zeta 1 (GSTZ1), a bifunctional enzyme that, as maleylacetoacetate isomerase (MAAI), catalyzes the penultimate step in tyrosine catabolism.	Tyrosine	185-193	glutathione S-transferase zeta 1	Homo sapiens	144-148
25079374-2	2015	DCA inhibits GSTZ1/MAAI, leading to delayed plasma drug clearance and to accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	13-18
25079374-2	2015	DCA inhibits GSTZ1/MAAI, leading to delayed plasma drug clearance and to accumulation of potentially toxic tyrosine intermediates.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	19-23
25079374-2	2015	DCA inhibits GSTZ1/MAAI, leading to delayed plasma drug clearance and to accumulation of potentially toxic tyrosine intermediates.	Tyrosine	107-115	glutathione S-transferase zeta 1	Homo sapiens	13-18
25079374-2	2015	DCA inhibits GSTZ1/MAAI, leading to delayed plasma drug clearance and to accumulation of potentially toxic tyrosine intermediates.	Tyrosine	107-115	glutathione S-transferase zeta 1	Homo sapiens	19-23
25079374-3	2015	Haplotype variability in GSTZ1 influences short-term DCA kinetics in healthy adults, but the impact of genotype in children treated chronically with DCA is unknown.	Dichloroacetic Acid	53-56	glutathione S-transferase zeta 1	Homo sapiens	25-30
25079374-5	2015	Plasma drug half-life and trough levels varied 3-6-fold, depending on GSTZ1/MAAI haplotype and correlated directly with urinary maleylacetone, a substrate for MAAI.	maleylacetone	128-141	glutathione S-transferase zeta 1	Homo sapiens	70-75
25079374-5	2015	Plasma drug half-life and trough levels varied 3-6-fold, depending on GSTZ1/MAAI haplotype and correlated directly with urinary maleylacetone, a substrate for MAAI.	maleylacetone	128-141	glutathione S-transferase zeta 1	Homo sapiens	76-80
25079374-5	2015	Plasma drug half-life and trough levels varied 3-6-fold, depending on GSTZ1/MAAI haplotype and correlated directly with urinary maleylacetone, a substrate for MAAI.	maleylacetone	128-141	glutathione S-transferase zeta 1	Homo sapiens	159-163
25079374-6	2015	However, chronic DCA exposure did not lead to progressive accumulation of plasma drug concentration; instead, kinetics parameters plateaued, consistent with the hypothesis that equipoise is established between the inhibitory effect of DCA on GSTZ1/MAAI and new enzyme synthesis.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	242-247
23280616-0	2013	Characterization of selenium-containing glutathione transferase zeta1-1 with high GPX activity prepared in eukaryotic cells.	Selenium	20-28	glutathione S-transferase zeta 1	Homo sapiens	40-71
23280616-4	2013	In this study, we have used directed mutagenesis and the inclusion of a selenocysteine (Sec) insertion sequence to engineer the expression in eukaryotic cells of human glutathione transferase zeta1-1 (hGSTZ1-1) with Sec in the active site (seleno-hGSTZ1-1).	Selenocysteine	72-86	glutathione S-transferase zeta 1	Homo sapiens	168-199
23280616-4	2013	In this study, we have used directed mutagenesis and the inclusion of a selenocysteine (Sec) insertion sequence to engineer the expression in eukaryotic cells of human glutathione transferase zeta1-1 (hGSTZ1-1) with Sec in the active site (seleno-hGSTZ1-1).	Selenocysteine	72-86	glutathione S-transferase zeta 1	Homo sapiens	201-209
22561244-7	2012	In this case a novel GPX activity of 2050+-225 U/mumol was introduced into hGSTZ1-1 by substitution of serine 15 by Sec 15.	Serine	103-109	glutathione S-transferase zeta 1	Homo sapiens	75-83
21642471-0	2012	Human polymorphisms in the glutathione transferase zeta 1/maleylacetoacetate isomerase gene influence the toxicokinetics of dichloroacetate.	Dichloroacetic Acid	124-139	glutathione S-transferase zeta 1	Homo sapiens	58-86
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	167-172
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	174-202
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	0-15	glutathione S-transferase zeta 1	Homo sapiens	204-208
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	167-172
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	174-202
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Dichloroacetic Acid	17-20	glutathione S-transferase zeta 1	Homo sapiens	204-208
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Phenylalanine	241-254	glutathione S-transferase zeta 1	Homo sapiens	167-172
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Phenylalanine	241-254	glutathione S-transferase zeta 1	Homo sapiens	174-202
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Phenylalanine	241-254	glutathione S-transferase zeta 1	Homo sapiens	204-208
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Tyrosine	255-263	glutathione S-transferase zeta 1	Homo sapiens	167-172
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Tyrosine	255-263	glutathione S-transferase zeta 1	Homo sapiens	174-202
21642471-1	2012	Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione transferase zeta (GSTz1)/maleylacetoacetate isomerase (MAAI), the penultimate enzyme in the phenylalanine/tyrosine catabolic pathway.	Tyrosine	255-263	glutathione S-transferase zeta 1	Homo sapiens	204-208
21642471-2	2012	The authors postulated that polymorphisms in GSTz1/MAAI modify the toxicokinetics of DCA.	Dichloroacetic Acid	85-88	glutathione S-transferase zeta 1	Homo sapiens	45-50
21642471-2	2012	The authors postulated that polymorphisms in GSTz1/MAAI modify the toxicokinetics of DCA.	Dichloroacetic Acid	85-88	glutathione S-transferase zeta 1	Homo sapiens	51-55
21642471-3	2012	GSTz1/MAAI haplotype significantly affected the kinetics and biotransformation of 1,2-13C-DCA when it was administered at either environmentally (microg/kg/d) or clinically (mg/kg/d) relevant doses.	1,2-13c-dca	82-93	glutathione S-transferase zeta 1	Homo sapiens	0-5
22454423-10	2012	Two SNPs (rs2287396 [GSTZ1] and rs9524885 [ABCC4]) from glutathione metabolic pathway were associated with fatigue in unadjusted analysis.	Glutathione	56-67	glutathione S-transferase zeta 1	Homo sapiens	21-26
25079374-6	2015	However, chronic DCA exposure did not lead to progressive accumulation of plasma drug concentration; instead, kinetics parameters plateaued, consistent with the hypothesis that equipoise is established between the inhibitory effect of DCA on GSTZ1/MAAI and new enzyme synthesis.	Dichloroacetic Acid	235-238	glutathione S-transferase zeta 1	Homo sapiens	242-247
25079374-7	2015	GSTZ1/MAAI haplotype variability affects DCA kinetics and biotransformation.	Dichloroacetic Acid	41-44	glutathione S-transferase zeta 1	Homo sapiens	0-5
25079374-7	2015	GSTZ1/MAAI haplotype variability affects DCA kinetics and biotransformation.	Dichloroacetic Acid	41-44	glutathione S-transferase zeta 1	Homo sapiens	6-10
24297161-6	2014	Dosing was based on haplotype variation in glutathione transferase zeta 1/maleylacetoacetate isomerase (GSTZ1/MAAI), which participates in DCA and tyrosine catabolism.	Dichloroacetic Acid	139-142	glutathione S-transferase zeta 1	Homo sapiens	104-109
24297161-6	2014	Dosing was based on haplotype variation in glutathione transferase zeta 1/maleylacetoacetate isomerase (GSTZ1/MAAI), which participates in DCA and tyrosine catabolism.	Dichloroacetic Acid	139-142	glutathione S-transferase zeta 1	Homo sapiens	110-114
24297161-6	2014	Dosing was based on haplotype variation in glutathione transferase zeta 1/maleylacetoacetate isomerase (GSTZ1/MAAI), which participates in DCA and tyrosine catabolism.	Tyrosine	147-155	glutathione S-transferase zeta 1	Homo sapiens	104-109
24297161-6	2014	Dosing was based on haplotype variation in glutathione transferase zeta 1/maleylacetoacetate isomerase (GSTZ1/MAAI), which participates in DCA and tyrosine catabolism.	Tyrosine	147-155	glutathione S-transferase zeta 1	Homo sapiens	110-114
24632415-0	2014	Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.	Chlorides	0-8	glutathione S-transferase zeta 1	Homo sapiens	86-91
24632415-0	2014	Chloride and other anions inhibit dichloroacetate-induced inactivation of human liver GSTZ1 in a haplotype-dependent manner.	Dichloroacetic Acid	34-49	glutathione S-transferase zeta 1	Homo sapiens	86-91
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	32-47	glutathione S-transferase zeta 1	Homo sapiens	159-188
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	32-47	glutathione S-transferase zeta 1	Homo sapiens	190-195
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	49-52	glutathione S-transferase zeta 1	Homo sapiens	159-188
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	Dichloroacetic Acid	49-52	glutathione S-transferase zeta 1	Homo sapiens	190-195
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	glyoxylic acid	134-144	glutathione S-transferase zeta 1	Homo sapiens	159-188
24632415-1	2014	The in vivo elimination rate of dichloroacetate (DCA), an investigational drug; is determined by the rate of its biotransformation to glyoxylate, catalyzed by glutathione transferase zeta1 (GSTZ1).	glyoxylic acid	134-144	glutathione S-transferase zeta 1	Homo sapiens	190-195
24632415-2	2014	DCA is a mechanism-based inactivator of GSTZ1, thus elimination of DCA is slowed with repeated dosing.	Dichloroacetic Acid	0-3	glutathione S-transferase zeta 1	Homo sapiens	40-45
24632415-2	2014	DCA is a mechanism-based inactivator of GSTZ1, thus elimination of DCA is slowed with repeated dosing.	Dichloroacetic Acid	67-70	glutathione S-transferase zeta 1	Homo sapiens	40-45
24632415-3	2014	We observed that chloride, a physiologically important anion, attenuated DCA-induced GSTZ1 inactivation in human liver cytosol in a concentration and GSTZ1 haplotype-dependent way.	Chlorides	17-25	glutathione S-transferase zeta 1	Homo sapiens	85-90
24632415-3	2014	We observed that chloride, a physiologically important anion, attenuated DCA-induced GSTZ1 inactivation in human liver cytosol in a concentration and GSTZ1 haplotype-dependent way.	Chlorides	17-25	glutathione S-transferase zeta 1	Homo sapiens	150-155
24632415-3	2014	We observed that chloride, a physiologically important anion, attenuated DCA-induced GSTZ1 inactivation in human liver cytosol in a concentration and GSTZ1 haplotype-dependent way.	Dichloroacetic Acid	73-76	glutathione S-transferase zeta 1	Homo sapiens	85-90
24632415-3	2014	We observed that chloride, a physiologically important anion, attenuated DCA-induced GSTZ1 inactivation in human liver cytosol in a concentration and GSTZ1 haplotype-dependent way.	Dichloroacetic Acid	73-76	glutathione S-transferase zeta 1	Homo sapiens	150-155
24632415-4	2014	In the absence of chloride, incubation with 0.5mM DCA resulted in inactivation of GSTZ1 with a half-life of 0.4h (samples with the KRT haplotype) to 0.5h (EGT haplotype).	Dichloroacetic Acid	50-53	glutathione S-transferase zeta 1	Homo sapiens	82-87
24632415-6	2014	The chloride concentration that protected 50% of the GSTZ1 activity following 2-h incubation with 0.5mM DCA (EC50) was 15.0+-3.1mM (mean+-S.D., n=3) for EGT samples and 36.2+-2.2mM for KRT samples.	Chlorides	4-12	glutathione S-transferase zeta 1	Homo sapiens	53-58
24632415-6	2014	The chloride concentration that protected 50% of the GSTZ1 activity following 2-h incubation with 0.5mM DCA (EC50) was 15.0+-3.1mM (mean+-S.D., n=3) for EGT samples and 36.2+-2.2mM for KRT samples.	Dichloroacetic Acid	104-107	glutathione S-transferase zeta 1	Homo sapiens	53-58
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Bromides	0-7	glutathione S-transferase zeta 1	Homo sapiens	43-48
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Iodides	9-15	glutathione S-transferase zeta 1	Homo sapiens	43-48
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Sulfites	20-27	glutathione S-transferase zeta 1	Homo sapiens	43-48
24632415-7	2014	Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA, however fluoride, sulfate, carbonate, acetate, cyanide did not.	Dichloroacetic Acid	70-73	glutathione S-transferase zeta 1	Homo sapiens	43-48
24632415-8	2014	Protection by bromide varied by GSTZ1 haplotype: EC50 was 1.3+-0.3mM for the EGT haplotype and 5.0+-0.60mM for the KRT haplotype.	Bromides	14-21	glutathione S-transferase zeta 1	Homo sapiens	32-37
24632415-10	2014	Because the in vivo half-life of DCA is determined by the fraction of active GSTZ1 in the liver, identifying factors that regulate GSTZ1 activity is important in determining appropriate DCA dosing in humans.	Dichloroacetic Acid	33-36	glutathione S-transferase zeta 1	Homo sapiens	77-82
24632415-10	2014	Because the in vivo half-life of DCA is determined by the fraction of active GSTZ1 in the liver, identifying factors that regulate GSTZ1 activity is important in determining appropriate DCA dosing in humans.	Dichloroacetic Acid	33-36	glutathione S-transferase zeta 1	Homo sapiens	131-136
24632415-10	2014	Because the in vivo half-life of DCA is determined by the fraction of active GSTZ1 in the liver, identifying factors that regulate GSTZ1 activity is important in determining appropriate DCA dosing in humans.	Dichloroacetic Acid	186-189	glutathione S-transferase zeta 1	Homo sapiens	131-136
21642471-3	2012	GSTz1/MAAI haplotype significantly affected the kinetics and biotransformation of 1,2-13C-DCA when it was administered at either environmentally (microg/kg/d) or clinically (mg/kg/d) relevant doses.	1,2-13c-dca	82-93	glutathione S-transferase zeta 1	Homo sapiens	6-10
21642471-4	2012	GSTz1/MAAI haplotype also influenced the urinary accumulation of potentially toxic tyrosine metabolites.	Tyrosine	83-91	glutathione S-transferase zeta 1	Homo sapiens	0-5
21642471-4	2012	GSTz1/MAAI haplotype also influenced the urinary accumulation of potentially toxic tyrosine metabolites.	Tyrosine	83-91	glutathione S-transferase zeta 1	Homo sapiens	6-10
21642471-5	2012	Atomic modeling revealed that GSTz1/MAAI variants associated with the slowest rates of DCA metabolism induced structural changes in the enzyme homodimer, predicting protein instability or abnormal protein-protein interactions.	Dichloroacetic Acid	87-90	glutathione S-transferase zeta 1	Homo sapiens	30-35
21642471-5	2012	Atomic modeling revealed that GSTz1/MAAI variants associated with the slowest rates of DCA metabolism induced structural changes in the enzyme homodimer, predicting protein instability or abnormal protein-protein interactions.	Dichloroacetic Acid	87-90	glutathione S-transferase zeta 1	Homo sapiens	36-40
21642471-6	2012	Knowledge of the GSTz1/MAAI haplotype can be used prospectively to identify individuals at potential risk of DCA"s adverse side effects from environmental or clinical exposure or who may exhibit aberrant amino acid metabolism in response to dietary protein.	Dichloroacetic Acid	109-112	glutathione S-transferase zeta 1	Homo sapiens	17-22
21642471-6	2012	Knowledge of the GSTz1/MAAI haplotype can be used prospectively to identify individuals at potential risk of DCA"s adverse side effects from environmental or clinical exposure or who may exhibit aberrant amino acid metabolism in response to dietary protein.	Dichloroacetic Acid	109-112	glutathione S-transferase zeta 1	Homo sapiens	23-27
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Tyrosine	118-126	glutathione S-transferase zeta 1	Homo sapiens	0-30
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Tyrosine	118-126	glutathione S-transferase zeta 1	Homo sapiens	32-37
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Tyrosine	118-126	glutathione S-transferase zeta 1	Homo sapiens	54-82
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	alpha-halocarboxylic acids	162-188	glutathione S-transferase zeta 1	Homo sapiens	0-30
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	alpha-halocarboxylic acids	162-188	glutathione S-transferase zeta 1	Homo sapiens	32-37
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	alpha-halocarboxylic acids	162-188	glutathione S-transferase zeta 1	Homo sapiens	54-82
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	200-219	glutathione S-transferase zeta 1	Homo sapiens	0-30
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	200-219	glutathione S-transferase zeta 1	Homo sapiens	32-37
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	200-219	glutathione S-transferase zeta 1	Homo sapiens	54-82
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	221-224	glutathione S-transferase zeta 1	Homo sapiens	0-30
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	221-224	glutathione S-transferase zeta 1	Homo sapiens	32-37
22028318-1	2012	Glutathione transferase zeta 1 (GSTZ1), also known as maleylacetoacetate isomerase, catalyzes the penultimate step of tyrosine catabolism and metabolizes several alpha-halocarboxylic acids, including dichloroacetic acid (DCA), an investigational drug used for lactic acidosis and, recently, solid tumors.	Dichloroacetic Acid	221-224	glutathione S-transferase zeta 1	Homo sapiens	54-82
22028318-3	2012	Here, we investigated the cytosolic GSTZ1 developmental expression pattern and the influence of haplotype on GSTZ1 activity with DCA by using human livers from donors between 10 weeks gestation and 74 years.	Dichloroacetic Acid	129-132	glutathione S-transferase zeta 1	Homo sapiens	109-114
22028318-7	2012	GSTZ1 activity with DCA was strongly associated with haplotype and expression level.	Dichloroacetic Acid	20-23	glutathione S-transferase zeta 1	Homo sapiens	0-5
22028318-13	2012	Haplotype influenced GSTZ1 activity with DCA but not protein expression.	Dichloroacetic Acid	41-44	glutathione S-transferase zeta 1	Homo sapiens	21-26