PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20682789-7	2010	Phosphorylation of Osterix at Ser-73/77 increased its ability to recruit p300 and SWI/SNF to either fibromodulin or bone sialoprotein promoters.	Serine	30-33	E1A binding protein p300	Mus musculus	73-77
19729597-5	2009	p300DeltaC/H3 significantly inhibited p300-induced activation of GATA- and myocyte enhancer factor 2-dependent promoters in cultured ventricular myocytes, and p300DeltaC/H3-TG mice showed cardiac dysfunction that was lethal by 20 weeks of age.	gata	65-69	E1A binding protein p300	Mus musculus	0-4
20660350-3	2010	In this study, we found that thapsigargin-induced ER stress augmented recruitment of IFN regulatory factor-3, CREB binding protein/p300, and transcriptional machinery to the murine ifnb1 promoter during LPS stimulation.	Thapsigargin	29-41	E1A binding protein p300	Mus musculus	131-135
20534877-11	2010	Chromatin immunoprecipitation assays indicated RARalpha and histone acetyltransferase p300 recruitment to, and acetylation of, histone H3 at the Mmp-9 promoter was greater after atRA treatment.	Tretinoin	178-182	E1A binding protein p300	Mus musculus	60-90
19883617-3	2009	Lysine 217 of FXR is the major acetylation site targeted by p300 and SIRT1.	Lysine	0-6	E1A binding protein p300	Mus musculus	60-64
19883617-6	2009	Surprisingly, in mouse models of metabolic disease, FXR interaction with SIRT1 and p300 was dramatically altered, FXR acetylation levels were elevated, and overexpression of SIRT1 or resveratrol treatment reduced acetylated FXR levels.	Resveratrol	183-194	E1A binding protein p300	Mus musculus	83-87
20797619-4	2010	Inhibition of the histone acetyltransferase (HAT) activity of p300 by a water-soluble, small molecule inhibitor, Hydrazinocurcumin (CTK7A), substantially reduced the xenografted oral tumor growth in mice.	Water	72-77	E1A binding protein p300	Mus musculus	62-66
20797619-4	2010	Inhibition of the histone acetyltransferase (HAT) activity of p300 by a water-soluble, small molecule inhibitor, Hydrazinocurcumin (CTK7A), substantially reduced the xenografted oral tumor growth in mice.	hydrazinocurcumin	113-130	E1A binding protein p300	Mus musculus	62-66
20403362-7	2010	Inhibition of the intrinsic histone acetyl-transferase activity of CBP/p300 with garcinol significantly suppressed collagen I expression in fibroblasts.	garcinol	81-89	E1A binding protein p300	Mus musculus	71-75
20016290-4	2010	HIF-1 dysfunction is the end result of reactive oxygen species-induced modification of its coactivator p300 by the glycolytic metabolite methylglyoxal.	Reactive Oxygen Species	39-62	E1A binding protein p300	Mus musculus	103-107
20016290-4	2010	HIF-1 dysfunction is the end result of reactive oxygen species-induced modification of its coactivator p300 by the glycolytic metabolite methylglyoxal.	Pyruvaldehyde	137-150	E1A binding protein p300	Mus musculus	103-107
19487584-2	2009	Overexpression of Ets-1 and p300 in mouse mesangial cells increased Npr1 promoter activity by 12-fold, natriuretic peptide receptor-A mRNA levels by 5-fold, and ANP-dependent intracellular accumulation of cGMP by 26-fold.	Cyclic GMP	205-209	E1A binding protein p300	Mus musculus	28-32
19680224-7	2009	The de-SUMOylating activity of SENP3 is required for ROS-induced increase of HIF-1 transactivation, but the true substrate of SENP3 is the co-activator of HIF-1 alpha, p300, rather than HIF-1 alpha itself.	Reactive Oxygen Species	53-56	E1A binding protein p300	Mus musculus	168-172
19377466-7	2009	Phosphorylation of Ser 536 is known to be essential for the transactivation function of p65, as it is required for recruitment of the transcriptional co-activator p300.	Serine	19-22	E1A binding protein p300	Mus musculus	163-167
19252138-6	2009	More modest enhancement of platelet recovery after 5-fluorouracil or bone marrow transplantation was also evident in p300(Plt6/+) animals.	Fluorouracil	51-65	E1A binding protein p300	Mus musculus	117-121
19359245-9	2009	Epc1 recruited histone acetyltransferase activity, which was potentiated by cotransfection with p300 but abolished by si-p300.	Silicon	118-120	E1A binding protein p300	Mus musculus	121-125
19290928-5	2009	Thus, Cabin1 and class II histone deacetylases have been found to constitute a novel calcium-signaling module in conjunction with the transcription factor myocyte enhance factor family and the transcriptional coactivator p300 to suppress and activate cytokine gene transcription in a calcium-dependent manner.	Calcium	85-92	E1A binding protein p300	Mus musculus	221-225
19150979-6	2009	Interestingly, the expression level of pluripotency marker Nanog but not Oct4 was markedly lower in EBs from p300(-/-) ES cells compared with that in EBs from wild-type ES cells.	ethylbenzene	100-103	E1A binding protein p300	Mus musculus	109-113
18842595-10	2008	Surprisingly, p300 down-regulation altered expression of other metabolic FXR target genes involved in lipoprotein and glucose metabolism, such that beneficial lipid and glucose profiles would be expected.	Glucose	118-125	E1A binding protein p300	Mus musculus	14-18
18842595-10	2008	Surprisingly, p300 down-regulation altered expression of other metabolic FXR target genes involved in lipoprotein and glucose metabolism, such that beneficial lipid and glucose profiles would be expected.	Glucose	169-176	E1A binding protein p300	Mus musculus	14-18
16428436-7	2006	T cells lacking CBP or p300 had reduced tumor necrosis factor alpha gene expression in response to phorbol ester and ionophore, while signal-responsive gene expression in CBP- or p300-deficient macrophages was largely intact.	Phorbol Esters	99-112	E1A binding protein p300	Mus musculus	23-27
18849969-5	2008	After glucagon induction, CRTC2 stimulated gluconeogenic gene expression by an association with p300, which we show here is also activated by dephosphorylation at Ser 89 during fasting.	Serine	163-166	E1A binding protein p300	Mus musculus	96-100
18849969-6	2008	In turn, p300 increased hepatic CRTC2 activity by acetylating it at Lys 628, a site that also targets CRTC2 for degradation after its ubiquitination by the E3 ligase constitutive photomorphogenic protein (COP1).	Lysine	68-71	E1A binding protein p300	Mus musculus	9-13
18782771-7	2008	We previously reported that the STAT3 NH(2)-terminal domain is acetylated by p300 at Lys-49 and Lys-87.	Lysine	85-88	E1A binding protein p300	Mus musculus	77-81
18292803-2	2008	We hypothesized that curcumin, a natural polyphenolic compound abundant in the spice turmeric and a known suppressor of histone acetylation, would suppress cardiac hypertrophy through the disruption of p300 histone acetyltransferase-dependent (p300-HAT-dependent) transcriptional activation.	Curcumin	21-29	E1A binding protein p300	Mus musculus	202-206
18292803-2	2008	We hypothesized that curcumin, a natural polyphenolic compound abundant in the spice turmeric and a known suppressor of histone acetylation, would suppress cardiac hypertrophy through the disruption of p300 histone acetyltransferase-dependent (p300-HAT-dependent) transcriptional activation.	Curcumin	21-29	E1A binding protein p300	Mus musculus	244-248
18292803-6	2008	Further investigation demonstrated that curcumin abrogated histone acetylation, GATA4 acetylation, and DNA-binding activity through blocking p300-HAT activity.	Curcumin	40-48	E1A binding protein p300	Mus musculus	141-145
18292803-7	2008	Curcumin also blocked AB-induced inflammation and fibrosis through disrupting p300-HAT-dependent signaling pathways.	Curcumin	0-8	E1A binding protein p300	Mus musculus	78-82
18292803-8	2008	Our results indicate that curcumin has the potential to protect against cardiac hypertrophy, inflammation, and fibrosis through suppression of p300-HAT activity and downstream GATA4, NF-kappaB, and TGF-beta-Smad signaling pathways.	Curcumin	26-34	E1A binding protein p300	Mus musculus	143-147
17617452-3	2008	The activity of TSA in the transfection system was modified by co-expression of histone acetyltransferase p300 and HDAC1; whereas, that of HMBA was enhanced by co-expression of the TATA-binding protein TBP.	trichostatin A	16-19	E1A binding protein p300	Mus musculus	80-110
17074765-6	2006	In vitro glutathione S-transferase pulldown competition experiments revealed the SHP-mediated repression of Smad3 transactivation through competition with its co-activator p300.	Glutathione	9-20	E1A binding protein p300	Mus musculus	172-176
17023266-6	2006	Finally, oh(8)dG suppressed recruitment of STATs and p300 to the iNOS and COX-2 promoters, and inhibited H3 histone acetylation.	oh(8)dg	9-16	E1A binding protein p300	Mus musculus	53-57
16885360-7	2006	Localized in vivo (1)H NMR measurements on the tumors formed following s.c. implantation of these cells into mice showed an increase in the intensity of the peak from choline-containing compounds in the p300(-) tumors.	Choline	167-174	E1A binding protein p300	Mus musculus	203-207
16609073-7	2006	Melatonin inhibited p300 histone acetyltransferase (HAT) activity and abrogated p300-augmented COX-2 and iNOS expression.	Melatonin	0-9	E1A binding protein p300	Mus musculus	20-24
16609073-7	2006	Melatonin inhibited p300 histone acetyltransferase (HAT) activity and abrogated p300-augmented COX-2 and iNOS expression.	Melatonin	0-9	E1A binding protein p300	Mus musculus	80-84
16609073-9	2006	These results suggest that melatonin inhibits COX-2 and iNOS transcriptional activation by inhibiting p300 HAT activity, thereby suppressing p52 acetylation, binding, and transactivation.	Melatonin	27-36	E1A binding protein p300	Mus musculus	102-110
16461841-5	2006	As the result of its 2-amino acid substitution in the p300-histone acetyltransferase domain, this mutant lost its histone acetyltransferase activity and was unable to activate GATA-4-dependent transcription.	2-amino acid	21-33	E1A binding protein p300	Mus musculus	54-58
18458062-6	2008	Furthermore, mutation of leucine residues (L-->A) within a nuclear exclusion signal in the MTF-1 acidic domain impaired recruitment of p300 and zinc-dependent activation of the MT-I gene.	Leucine	25-32	E1A binding protein p300	Mus musculus	138-142
18504304-5	2008	MKP-1 is acetylated by p300 on lysine residue K57 within its substrate-binding domain.	Lysine	31-37	E1A binding protein p300	Mus musculus	23-27
17671180-5	2007	We also found that MTA1 acetylated on Lys(626) interacted with p300 histone acetyltransferase, and that acetylated MTA1 was recruited to the Pax5 promoter to stimulate Pax5 transcription.	Lysine	38-41	E1A binding protein p300	Mus musculus	63-67
17065349-5	2006	High glucose induced fibronectin expression in the endothelial cells, which was associated with increased p300, PARP activity, and NF-kappaB activation.	Glucose	5-12	E1A binding protein p300	Mus musculus	106-110
17065349-8	2006	Examination of the heart tissues of streptozotocin-induced diabetic mice revealed increased fibronectin and p300 mRNA.	Streptozocin	36-50	E1A binding protein p300	Mus musculus	108-112
17065349-10	2006	We further investigated retinal tissues from streptozotocin-induced diabetic rats treated with intravitreal p300 siRNA injection.	Streptozocin	45-59	E1A binding protein p300	Mus musculus	108-112
16768624-1	2006	Cyclic adenosine monophosphate response element binding protein (CREB) binding protein (CBP) and E1A binding protein (p300) are highly homologous transcriptional coactivators with histone acetyltransferase activity.	Cyclic AMP	0-30	E1A binding protein p300	Mus musculus	118-122
16285960-6	2005	RESULTS: Two Lys residues at amino acids 49 and 87 in the STAT3 NH2 terminus are acetylated by p300.	Lysine	13-16	E1A binding protein p300	Mus musculus	95-99
16237459-1	2005	The C-terminal activation domain (C-TAD) of the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha binds the CH1 domains of the related transcriptional coactivators CREB-binding protein (CBP) and p300, an oxygen-regulated interaction thought to be highly essential for hypoxia-responsive transcription.	Oxygen	220-226	E1A binding protein p300	Mus musculus	211-215
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Lysine	0-3	E1A binding protein p300	Mus musculus	97-101
16285960-7	2005	Lys-to-Arg point mutations (STAT3 K49R/K87R) had no effect on inducible DNA binding, but blocked p300-mediated acetyl(Ac)-STAT3 formation and abrogated IL-6-induced hAGT activation.	Arginine	7-10	E1A binding protein p300	Mus musculus	97-101
16135789-4	2005	Using anti-acetylated lysine 310 RelA antibodies, we detected p300-mediated acetylation of RelA in vitro and in vivo after stimulation of cells with tumor necrosis factor alpha (TNF-alpha).	Lysine	22-28	E1A binding protein p300	Mus musculus	62-66
16186500-0	2005	Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells.	glucocorticosteroid	70-89	E1A binding protein p300	Mus musculus	62-66
16186500-3	2005	Glucocorticosteroid-stimulated gene transcription is mediated by the glucocorticosteroid receptor (GR) that recruits coactivators of the p160 family, forming a docking platform for secondary coactivators, such as cAMP-response element binding protein (CREB)-binding protein (CBP) or its close homologue, p300.	Cyclic AMP	213-217	E1A binding protein p300	Mus musculus	304-308
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Serine	40-46	E1A binding protein p300	Mus musculus	105-109
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Serine	54-60	E1A binding protein p300	Mus musculus	105-109
16135789-6	2005	Furthermore, phosphorylation of RelA on serine 276 or serine 536 increased assembly of phospho-RelA with p300, which enhanced acetylation on lysine 310.	Lysine	141-147	E1A binding protein p300	Mus musculus	105-109
15496408-2	2004	Furthermore, we have shown that the glucose-mediated hyperacetylation of histone H4 depends on the recruitment of the histone acetyltransferase p300 by the beta cell-specific transcription factor Pdx-1.	Glucose	36-43	E1A binding protein p300	Mus musculus	144-148
14625279-0	2004	Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin.	Polycyclic Aromatic Hydrocarbons	37-68	E1A binding protein p300	Mus musculus	166-170
15476823-2	2004	The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2.	Cysteine	125-133	E1A binding protein p300	Mus musculus	85-89
15476823-2	2004	The site of interaction of the tumor suppressor p53 and the oncoprotein E1A with CBP/p300 has been identified with the third cysteine-histidine-rich (CH3) domain, which incorporates two zinc-binding motifs, ZZ and TAZ2.	Histidine	134-143	E1A binding protein p300	Mus musculus	85-89
15024056-7	2004	We demonstrated that FoxM1B transcriptional activity requires binding of either S-phase or M-phase Cdk-cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue, which is essential for recruitment of p300/CBP coactivator proteins.	Threonine	175-178	E1A binding protein p300	Mus musculus	230-234
15465599-7	2004	The modulation of LPS-induced NF-kappaB by ethanol was due to the inhibition of coactivator p300.	Ethanol	43-50	E1A binding protein p300	Mus musculus	92-96
15123621-8	2004	Overexpression of p300 suppressed retinoblastoma protein-dependent gene repression, and this effect was reversed by TCDD.	Polychlorinated Dibenzodioxins	116-120	E1A binding protein p300	Mus musculus	18-22
15123621-9	2004	Chromatin immunoprecipitation assays showed that TCDD treatment caused the recruitment of AHR to E2F-dependent promoters and the concurrent displacement of p300.	Polychlorinated Dibenzodioxins	49-53	E1A binding protein p300	Mus musculus	156-160
14975762-2	2004	Doxorubicin depletes cardiac p300, a transcriptional coactivator that is required for the maintenance of the differentiated phenotype of cardiac myocytes.	Doxorubicin	0-11	E1A binding protein p300	Mus musculus	29-33
14975762-4	2004	Transgenic mice overexpressing p300 in the heart and wild-type mice were subjected to doxorubicin treatment.	Doxorubicin	86-97	E1A binding protein p300	Mus musculus	31-35
14975762-8	2004	These findings demonstrate that overexpression of p300 protects cardiac myocytes from doxorubicin-induced apoptosis and reduces the extent of acute heart failure in adult mice in vivo.	Doxorubicin	86-97	E1A binding protein p300	Mus musculus	50-54
12888559-0	2003	Concomitant increase of histone acetyltransferase activity and degradation of p300 during retinoic acid-induced differentiation of F9 cells.	Tretinoin	90-103	E1A binding protein p300	Mus musculus	78-82
12888559-2	2003	Despite their similarities, p300 and CBP have distinct functions during retinoic acid-induced differentiation of mouse F9 embryonal carcinoma cells.	Tretinoin	72-85	E1A binding protein p300	Mus musculus	28-32
12888559-6	2003	We report a dramatic decrease of p300, but not CBP protein levels, after 48 h of retinoic acid treatment.	Tretinoin	81-94	E1A binding protein p300	Mus musculus	33-37
14500836-8	2003	Recruitment of p300 to the NIC-containing complex was facilitated by activated Smad1, which is suggested to contribute to BMP2-mediated enhancement of Notch-induced Hes-5 expression.	Nicotine	27-30	E1A binding protein p300	Mus musculus	15-19
11689682-6	2001	In chromatin immunoprecipitation assays of NIH 3T3 cells, cAMP-dependent recruitment of p300 to the somatostatin promoter stimulated acetylation of histone H4.	Cyclic AMP	58-62	E1A binding protein p300	Mus musculus	88-92
12665509-3	2003	Previous data demonstrate that the transcription factors Beta-2/NeuroD1 and Pdx-1, which are involved in glucose-stimulated insulin gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylation in glucose regulation of the insulin gene expression.	Glucose	105-112	E1A binding protein p300	Mus musculus	185-189
12665509-3	2003	Previous data demonstrate that the transcription factors Beta-2/NeuroD1 and Pdx-1, which are involved in glucose-stimulated insulin gene expression, interact with the histone acetylase p300, suggesting a role for histone acetylation in glucose regulation of the insulin gene expression.	Glucose	236-243	E1A binding protein p300	Mus musculus	185-189
12628477-6	2003	YM440 and rosiglitazone induced interaction between PPARgamma and the transcriptional cofactor, p300 or SRC-1, but YM440 was 151- and 1091-fold less potent than rosiglitazone, respectively.	Rosiglitazone	10-23	E1A binding protein p300	Mus musculus	96-100
12628477-6	2003	YM440 and rosiglitazone induced interaction between PPARgamma and the transcriptional cofactor, p300 or SRC-1, but YM440 was 151- and 1091-fold less potent than rosiglitazone, respectively.	Rosiglitazone	161-174	E1A binding protein p300	Mus musculus	96-100
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Oxygen	0-6	E1A binding protein p300	Mus musculus	167-171
12133832-5	2002	Oxygen-dependent hydroxylation of an asparagine residue has recently been reported to regulate C-TAD function by disrupting the interaction with the CH1 domain of the p300/CBP coactivator at normoxia.	Asparagine	37-47	E1A binding protein p300	Mus musculus	167-171
12072388-10	2002	cAMP response element binding protein-binding protein (CBP)/p300 levels also varied between tissues.	Cyclic AMP	0-4	E1A binding protein p300	Mus musculus	60-64
11991651-4	2002	Furthermore, overexpression of the coactivator p300 restored BADGE- or pioglitazone hydrochloride-suppressed promoter activity of the nuclear factor-kappa B (NF-kappaB)-luciferase reporter gene, suggesting that PPARgamma may interfere with NF-kappaB transcriptional activity via coactivator competition.	Pioglitazone	71-97	E1A binding protein p300	Mus musculus	47-51
12730195-6	2003	The N-terminal region of B3BP that contains the ATP-binding site is important for the interaction with BCL-3 and p300/CBP.	Adenosine Triphosphate	48-51	E1A binding protein p300	Mus musculus	113-117
12724418-5	2003	In primary cardiac myocytes derived from neonatal rats, we show that stimulation with phenylephrine increased an acetylated form of GATA-4 and its DNA-binding activity, as well as expression of p300.	Phenylephrine	86-99	E1A binding protein p300	Mus musculus	194-198
12724418-6	2003	A dominant-negative mutant of p300 suppressed phenylephrine-induced nuclear acetylation, activation of GATA-4-dependent endothelin-1 promoters, and hypertrophic responses, such as increase in cell size and sarcomere organization.	Phenylephrine	46-59	E1A binding protein p300	Mus musculus	30-34
11481322-4	2001	Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments.	Cysteine	88-96	E1A binding protein p300	Mus musculus	131-135
11481322-4	2001	Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments.	Histidine	97-106	E1A binding protein p300	Mus musculus	131-135
11481322-4	2001	Direct physical interactions between the N- and C-zinc finger domains of GATA-4 and the cysteine/histidine-rich region 3 (C/H3) of p300 were identified in immunoprecipitation and glutathione S-transferase pull-down experiments.	Glutathione	179-190	E1A binding protein p300	Mus musculus	131-135
10490830-5	1999	p300 was found to coimmunoprecipitate with Tal1 in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and p300 and Tal1 were observed in a common E box DNA-binding complex in extracts from differentiating MEL cells.	Dimethyl Sulfoxide	130-147	E1A binding protein p300	Mus musculus	0-4
10760264-1	2000	The cAMP response element binding protein (CREB)-binding protein (CBP)/p300 family of coactivator proteins regulates gene transcription through the integration of multiple signal transduction pathways.	Cyclic AMP	4-8	E1A binding protein p300	Mus musculus	71-75
10574992-6	1999	Conversely, E1A binding to only p300/CBP results in an increase in PARP enzyme activity and consequently in cell death susceptibility to irradiation, which is effectively counteracted by the PARP chemical inhibitor 3-aminobenzamide.	3-aminobenzamide	215-231	E1A binding protein p300	Mus musculus	32-36
10490830-5	1999	p300 was found to coimmunoprecipitate with Tal1 in extracts from murine erythroleukemia (MEL) cells induced to differentiate with dimethylsulfoxide (DMSO), and p300 and Tal1 were observed in a common E box DNA-binding complex in extracts from differentiating MEL cells.	Dimethyl Sulfoxide	149-153	E1A binding protein p300	Mus musculus	0-4
10066817-12	1999	Sodium butyrate, an inhibitor of histone deacetylase, mimicked p300/CBP function in activation of ferritin H-CAT and elevation of endogenous ferritin H mRNA, suggesting that the histone acetyltransferase activity of p300/CBP or its associated proteins may contribute to the activation of ferritin H transcription.	Butyric Acid	0-15	E1A binding protein p300	Mus musculus	63-67
10066817-12	1999	Sodium butyrate, an inhibitor of histone deacetylase, mimicked p300/CBP function in activation of ferritin H-CAT and elevation of endogenous ferritin H mRNA, suggesting that the histone acetyltransferase activity of p300/CBP or its associated proteins may contribute to the activation of ferritin H transcription.	Butyric Acid	0-15	E1A binding protein p300	Mus musculus	216-220
34146546-0	2021	Dimethyl sulfoxide (DMSO) enhances direct cardiac reprogramming by inhibiting the bromodomain of coactivators CBP/p300.	Dimethyl Sulfoxide	0-18	E1A binding protein p300	Mus musculus	114-118
9223672-4	1997	This region of Mi is also highly conserved with a region of E1A known to be essential for binding the CBP/p300 transcription cofactor.	2-methyl-4-isothiazolin-3-one	15-17	E1A binding protein p300	Mus musculus	106-110
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	E1A binding protein p300	Mus musculus	196-200
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	E1A binding protein p300	Mus musculus	196-200
7651731-4	1995	Keratinocytes transfected with the mutant d1787N (which binds to p60, p105, p107 and p300) showed a lethality in response to CDDP (10 micrograms ml-1) fourfold higher than controls and threefold higher in response to DOX and radiation (5 grays).	Cisplatin	125-129	E1A binding protein p300	Mus musculus	85-89
7651731-4	1995	Keratinocytes transfected with the mutant d1787N (which binds to p60, p105, p107 and p300) showed a lethality in response to CDDP (10 micrograms ml-1) fourfold higher than controls and threefold higher in response to DOX and radiation (5 grays).	Doxorubicin	217-220	E1A binding protein p300	Mus musculus	85-89
7651731-8	1995	From these results, we conclude that cell sensitivity to cisplatin and ionizing radiation induced by the E1a oncogene requires binding to p105, p107 and p300 cellular proteins, while sensitivity to Doxorubicin requires binding only to p300.	Cisplatin	57-66	E1A binding protein p300	Mus musculus	153-157
7651731-8	1995	From these results, we conclude that cell sensitivity to cisplatin and ionizing radiation induced by the E1a oncogene requires binding to p105, p107 and p300 cellular proteins, while sensitivity to Doxorubicin requires binding only to p300.	Cisplatin	57-66	E1A binding protein p300	Mus musculus	235-239
34953958-2	2022	p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 (H3K27ac) and is activated during fibrosis.	Lysine	48-54	E1A binding protein p300	Mus musculus	0-4
34146546-0	2021	Dimethyl sulfoxide (DMSO) enhances direct cardiac reprogramming by inhibiting the bromodomain of coactivators CBP/p300.	Dimethyl Sulfoxide	20-24	E1A binding protein p300	Mus musculus	114-118
34146546-7	2021	Subsequent experiments using small molecule screening revealed that DMSO enhances direct cardiac reprogramming through inhibition of the CBP/p300 bromodomain, and not its acetyltransferase property.	Dimethyl Sulfoxide	68-72	E1A binding protein p300	Mus musculus	141-145
34112215-8	2021	In mice with dextran sulfate sodium (DSS)-induced acute colitis, an EP300 inhibitor significantly inhibited colitis.	Dextran Sulfate	13-35	E1A binding protein p300	Mus musculus	68-73
34416629-0	2021	Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.	Albendazole	0-11	E1A binding protein p300	Mus musculus	61-65
34416629-0	2021	Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1alpha-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression.	Diethylnitrosamine	101-119	E1A binding protein p300	Mus musculus	61-65
34572988-4	2021	In this study, we aimed at investigating the potential role of p300/CBP in the up-regulation of renal NADPH oxidase (Nox), reactive oxygen species (ROS) production, inflammation, and fibrosis in diabetic mice.	Reactive Oxygen Species	123-146	E1A binding protein p300	Mus musculus	63-67
34572988-4	2021	In this study, we aimed at investigating the potential role of p300/CBP in the up-regulation of renal NADPH oxidase (Nox), reactive oxygen species (ROS) production, inflammation, and fibrosis in diabetic mice.	Reactive Oxygen Species	148-151	E1A binding protein p300	Mus musculus	63-67
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	113-119	E1A binding protein p300	Mus musculus	90-94
34110772-3	2021	Here, we analyzed a series of selective inhibitors acting on multidomain proteins CBP and p300 that contain both lysine acetyltransferase and bromodomains and are responsible for the recognition and enzymatic modification of lysine residues.	Lysine	225-231	E1A binding protein p300	Mus musculus	90-94
34365659-7	2021	In this study, we identified CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as one such cell-intrinsic negative regulator of inflammation.	Glutamic Acid	70-83	E1A binding protein p300	Mus musculus	33-37
34365659-7	2021	In this study, we identified CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) as one such cell-intrinsic negative regulator of inflammation.	Aspartic Acid	84-97	E1A binding protein p300	Mus musculus	33-37
34322027-4	2021	Here, we identified that C646, an inhibitor of histone acetyltransferase p300, exerts anti-inflammatory effects in DSS-induced colitis mice by targeting the NLRP3 inflammasome.	C646	25-29	E1A binding protein p300	Mus musculus	73-77
34112215-8	2021	In mice with dextran sulfate sodium (DSS)-induced acute colitis, an EP300 inhibitor significantly inhibited colitis.	Dextran Sulfate	37-40	E1A binding protein p300	Mus musculus	68-73
35502657-12	2022	TET2 coimmunoprecipitated with p300, and this interaction was enhanced by rapamycin but repressed by platelet-derived growth factor (PDGF) treatment, with p300 promoting TET2 protein stability.	Sirolimus	74-83	E1A binding protein p300	Mus musculus	31-35
35320012-0	2022	Tamarixetin Abrogates Adipogenesis Through Inhibiting p300/CBP-Associated Factor Acetyltransferase Activity in 3T3-L1 Preadipocyte Cells.	tamarixetin	0-11	E1A binding protein p300	Mus musculus	54-58
35472077-7	2022	Additional biochemical, cellular, proteomic, and genomic analyses demonstrated that ADPRylation of H2B-D51 inhibits p300-mediated acetylation of H2B at many Lys residues.	Lysine	157-160	E1A binding protein p300	Mus musculus	116-120
34100419-4	2022	Consistent with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4 (SRRM4) protein, the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons, RSTS iNeurons show downregulated genes for proteins impacting this network.	Serine	68-74	E1A binding protein p300	Mus musculus	209-214
35231103-9	2022	RBBP4/p300 complex was demonstrated in the nucleus, and shRBBP4 or shp300 significantly sensitized GBM cells to TMZ compared to the control shNT in vitro (p<0.05).	Temozolomide	112-115	E1A binding protein p300	Mus musculus	6-10
35231103-11	2022	CREB-binding protein (CBP)/p300 inhibitor CPI-1612 suppressed H3K27Ac and RBBP4/p300 complex target proteins, including C-MYC, and synergistically sensitized TMZ in vitro.	CHEMBL4641354	42-50	E1A binding protein p300	Mus musculus	27-31
35231103-11	2022	CREB-binding protein (CBP)/p300 inhibitor CPI-1612 suppressed H3K27Ac and RBBP4/p300 complex target proteins, including C-MYC, and synergistically sensitized TMZ in vitro.	CHEMBL4641354	42-50	E1A binding protein p300	Mus musculus	80-84
35231103-11	2022	CREB-binding protein (CBP)/p300 inhibitor CPI-1612 suppressed H3K27Ac and RBBP4/p300 complex target proteins, including C-MYC, and synergistically sensitized TMZ in vitro.	Temozolomide	158-161	E1A binding protein p300	Mus musculus	27-31
35242497-0	2022	TWIST1-EP300 Expedites Gastric Cancer Cell Resistance to Apatinib by Activating the Expression of COL1A2.	apatinib	57-65	E1A binding protein p300	Mus musculus	7-12
35242497-6	2022	In addition, overexpression of COL1A2 significantly promoted resistance to apatinib in GC cells, but knockdown of EP300 or TWIST1 remarkably inhibited COL1A2 expression and promoted sensitivity of GC cells to apatinib.	apatinib	75-83	E1A binding protein p300	Mus musculus	114-119
35242497-6	2022	In addition, overexpression of COL1A2 significantly promoted resistance to apatinib in GC cells, but knockdown of EP300 or TWIST1 remarkably inhibited COL1A2 expression and promoted sensitivity of GC cells to apatinib.	apatinib	209-217	E1A binding protein p300	Mus musculus	114-119
35242497-7	2022	Our findings demonstrated that the combination of EP300 and TWIST1 has a synergistically regulatory effect on COL1A2 expression, thus contributing to apatinib resistance in GC cells.	apatinib	150-158	E1A binding protein p300	Mus musculus	50-55
35159132-7	2022	Binding of RA to RARs regulates recruitment of transcriptional coregulators such as nuclear receptor coactivator (NCOA) or nuclear receptor corepressor (NCOR), which in turn control binding of the generic coactivator p300 or the generic corepressor PRC2.	Tretinoin	11-13	E1A binding protein p300	Mus musculus	217-221
34100419-4	2022	Consistent with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4 (SRRM4) protein, the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons, RSTS iNeurons show downregulated genes for proteins impacting this network.	Arginine	75-83	E1A binding protein p300	Mus musculus	209-214
33978814-3	2021	Tau acetylation occurs at lysine 280 resulting from increased expression of the lysine acetyltransferase p300.	Lysine	26-32	E1A binding protein p300	Mus musculus	105-109
33978814-3	2021	Tau acetylation occurs at lysine 280 resulting from increased expression of the lysine acetyltransferase p300.	Lysine	80-86	E1A binding protein p300	Mus musculus	105-109
33574568-12	2021	This study reveals that SL010110 is a lead compound with a distinct mechanism of suppressing gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and potent anti-hyperglycemic activity for the treatment of T2D.	sl010110	24-32	E1A binding protein p300	Mus musculus	119-123
33626422-0	2021	p300/CBP inhibitor A-485 inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss.	A-485	19-24	E1A binding protein p300	Mus musculus	0-4
33626422-3	2021	In this study, we investigated whether A-485, a highly selective catalytic p300/CBP inhibitor, could attenuate RANKL-induced osteoclast differentiation and explored the underlying molecular mechanisms.	A-485	39-44	E1A binding protein p300	Mus musculus	75-79
33574568-0	2021	SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice.	sl010110	0-8	E1A binding protein p300	Mus musculus	62-66
33574568-7	2021	The enhanced PEPCK1 acetylation and suppressed gluconeogenesis caused by SL010110 were blocked by C646, a histone acetyltransferase p300 inhibitor, suggested that SL010110 inhibited gluconeogenesis by activating p300.	sl010110	73-81	E1A binding protein p300	Mus musculus	132-136
33327548-0	2020	Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice.	garcinol	22-30	E1A binding protein p300	Mus musculus	14-18
33574568-7	2021	The enhanced PEPCK1 acetylation and suppressed gluconeogenesis caused by SL010110 were blocked by C646, a histone acetyltransferase p300 inhibitor, suggested that SL010110 inhibited gluconeogenesis by activating p300.	C646	98-102	E1A binding protein p300	Mus musculus	132-136
33574568-7	2021	The enhanced PEPCK1 acetylation and suppressed gluconeogenesis caused by SL010110 were blocked by C646, a histone acetyltransferase p300 inhibitor, suggested that SL010110 inhibited gluconeogenesis by activating p300.	C646	98-102	E1A binding protein p300	Mus musculus	212-216
33574568-7	2021	The enhanced PEPCK1 acetylation and suppressed gluconeogenesis caused by SL010110 were blocked by C646, a histone acetyltransferase p300 inhibitor, suggested that SL010110 inhibited gluconeogenesis by activating p300.	sl010110	163-171	E1A binding protein p300	Mus musculus	132-136
33574568-7	2021	The enhanced PEPCK1 acetylation and suppressed gluconeogenesis caused by SL010110 were blocked by C646, a histone acetyltransferase p300 inhibitor, suggested that SL010110 inhibited gluconeogenesis by activating p300.	sl010110	163-171	E1A binding protein p300	Mus musculus	212-216
33574568-9	2021	These effects were blocked by NMN, an NAD+ precursor, suggested that SL010110 inhibited gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 acetylation.	sl010110	69-77	E1A binding protein p300	Mus musculus	136-140
33574568-10	2021	In type 2 diabetic ob/ob mice, single oral dose of SL010110 (100 mg/kg) suppressed gluconeogenesis accompanied by the suppressed hepatic SIRT2 activity, increased p300 activity, enhanced PEPCK1 acetylation and degradation.	sl010110	51-59	E1A binding protein p300	Mus musculus	163-167
33441918-10	2021	Moreover, miR-494-3p mimic reduced the levels of p300, MYOD, and MYH2 in skeletal muscles in mice.	mir-494-3p	10-20	E1A binding protein p300	Mus musculus	49-53
33074715-7	2021	The lactate inductions of the histone lactylation and profibrotic gene expression were mediated by p300, as evidenced by their diminished concentrations in p300-knockdown macrophages.	Lactic Acid	4-11	E1A binding protein p300	Mus musculus	99-103
33074715-7	2021	The lactate inductions of the histone lactylation and profibrotic gene expression were mediated by p300, as evidenced by their diminished concentrations in p300-knockdown macrophages.	Lactic Acid	4-11	E1A binding protein p300	Mus musculus	156-160
33663922-11	2021	Mechanistically, the histone acetylation inhibition by naringenin and hesperetin was achieved through regulating AMPK-mediated p300 inactivation.	naringenin	55-65	E1A binding protein p300	Mus musculus	127-131
33663922-11	2021	Mechanistically, the histone acetylation inhibition by naringenin and hesperetin was achieved through regulating AMPK-mediated p300 inactivation.	hesperetin	70-80	E1A binding protein p300	Mus musculus	127-131
33327548-0	2020	Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice.	Cisplatin	48-57	E1A binding protein p300	Mus musculus	14-18
33327548-3	2020	However, the role of p300 in cisplatin-induced AKI remains poorly understood.	Cisplatin	29-38	E1A binding protein p300	Mus musculus	21-25
33327548-4	2020	Therefore, we investigated the effects of garcinol, a potent p300 inhibitor, on cisplatin-induced AKI and explored the mechanisms.	garcinol	42-50	E1A binding protein p300	Mus musculus	61-65
33327548-5	2020	Administration of garcinol significantly reversed the upregulation of p300 and increased acetylation of histone H3, along with amelioration of renal dysfunction and histopathological injury in the kidneys of cisplatin-injected mice.	garcinol	18-26	E1A binding protein p300	Mus musculus	70-74
33327548-10	2020	Taken together, we demonstrated that the inhibition of p300 by garcinol ameliorated cisplatin-induced renal injury, presumably through epigenetic mechanisms.	garcinol	63-71	E1A binding protein p300	Mus musculus	55-59
33327548-10	2020	Taken together, we demonstrated that the inhibition of p300 by garcinol ameliorated cisplatin-induced renal injury, presumably through epigenetic mechanisms.	Cisplatin	84-93	E1A binding protein p300	Mus musculus	55-59
32917859-0	2020	Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis.	A-485	40-45	E1A binding protein p300	Mus musculus	28-32
33292328-11	2020	Cerulenin disrupted the assembly of the TonEBP/NF-kappaB/AP-1/p300 complex and suppressed the LPS-induced microglial activation and the neuronal damages in animals.	Cerulenin	0-9	E1A binding protein p300	Mus musculus	62-66
32991875-13	2020	CONCLUSIONS: These findings demonstrate that nuclear-localized Bag6 and p300 co-operatively enhance FoxO1 acetylation to promote FasL-mediated MEE apoptosis during palate fusion.	mee	143-146	E1A binding protein p300	Mus musculus	72-76
32917859-3	2020	Here, C57BL/6 mice fed with either normal chow diet (NCD) or high-fat diet (HFD) were administrated with A-485, a recently reported selective inhibitor of CBP/p300 HAT activity for 1 week and the metabolic change was analyzed.	A-485	105-110	E1A binding protein p300	Mus musculus	159-163
33303988-0	2021	3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.	4-methylcatechol	0-20	E1A binding protein p300	Mus musculus	130-134
33303988-0	2021	3,4-dihydroxytoluene, a metabolite of rutin, suppresses the progression of nonalcoholic fatty liver disease in mice by inhibiting p300 histone acetyltransferase activity.	Rutin	38-43	E1A binding protein p300	Mus musculus	130-134
33298861-1	2020	Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300.	Salicylates	0-10	E1A binding protein p300	Mus musculus	217-222
33298861-1	2020	Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300.	Aspirin	37-44	E1A binding protein p300	Mus musculus	217-222
33298861-1	2020	Salicylate, the active derivative of aspirin (acetylsalicylate), recapitulates the mode of action of caloric restriction inasmuch as it stimulates autophagy through the inhibition of the acetyltransferase activity of EP300.	Aspirin	46-62	E1A binding protein p300	Mus musculus	217-222
33298861-4	2020	However, these effects on global protein acetylation could not be attributed to the mere inhibition of EP300, as determined by epistatic experiments and exploration of the acetyl-proteome from salicylate-treated EP300-deficient cells.	Salicylates	193-203	E1A binding protein p300	Mus musculus	212-217
32791154-7	2020	To investigate the effects of P300 on autophagy and myofiber remodeling, a P300 specific inhibitor, c646, was utilized.	C646	100-104	E1A binding protein p300	Mus musculus	75-79
32791154-9	2020	KEY FINDINGS: Phosphorylation of P300 in response to PA enhanced its activity and subsequently suppressed autophagic flux, leading to atrophy-related morphological and molecular changes in myotubes.	Palmitic Acid	53-55	E1A binding protein p300	Mus musculus	33-37
32791154-10	2020	Inhibition of P300 reestablished autophagic flux and ameliorated PA-induced myotubes atrophy.	Palmitic Acid	65-67	E1A binding protein p300	Mus musculus	14-18
32865093-10	2020	Treatment with C646 significantly reduced levels of p300 and H3K56 acetylation in SIRT3KO mice.	C646	15-19	E1A binding protein p300	Mus musculus	52-56
32865093-13	2020	Conclusions C646 treatment attenuated p300 and H3K56 acetylation and improved arterial stiffness and CFR via improvement of endothelial cell (EC) dysfunction and suppression of NF-kappaB.	C646	12-16	E1A binding protein p300	Mus musculus	38-42
32434298-5	2020	Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro.	nsm00158	95-103	E1A binding protein p300	Mus musculus	156-160
32690000-1	2020	BACKGROUND: The transcription coactivators CREB binding protein (CBP) and p300 are highly homologous acetyltransferases that mediate histone 3 lysine 27 acetylation (H3K27ac) at regulatory elements such as enhancers and promoters.	Lysine	143-149	E1A binding protein p300	Mus musculus	74-78
32445665-0	2020	Role of Cbp, p300 and Akt in valproic acid induced neural tube defects in CD-1 mouse embryos.	Valproic Acid	29-42	E1A binding protein p300	Mus musculus	13-17
32445665-12	2020	Downregulated expression of Cbp, p300, and Akt may play a key role in VPA-induced neural tube defects considering their vitally important role in embryonic development.	Valproic Acid	70-73	E1A binding protein p300	Mus musculus	33-37
32311286-0	2020	Plumbagin Suppresses Pulmonary Fibrosis Via Inhibition of p300 Histone Acetyltransferase Activity.	plumbagin	0-9	E1A binding protein p300	Mus musculus	58-62
32311286-3	2020	In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, was screened for p300 inhibitory activity.	plumbagin	36-45	E1A binding protein p300	Mus musculus	117-121
32311286-4	2020	Plumbagin specifically inhibited the activity of p300 toward histone acetyltransferases.	plumbagin	0-9	E1A binding protein p300	Mus musculus	49-53
31898871-3	2020	METHODS: Mice with skeletal muscle-specific and inducible knockout of p300 and CBP (PCKO) were generated by crossing mice with a tamoxifen-inducible Cre recombinase expressed under the human alpha-skeletal actin promoter with mice having LoxP sites flanking exon 9 of the Ep300 and Crebbp genes.	Tamoxifen	129-138	E1A binding protein p300	Mus musculus	70-74
32444594-1	2020	The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain unclear.	Lysine	4-10	E1A binding protein p300	Mus musculus	67-71
31927229-3	2020	Here we demonstrate that fluoride activates histone acetyltransferases (HATs) including CBP, p300, PCAF and Tip60 to acetylate p53.	Fluorides	25-33	E1A binding protein p300	Mus musculus	93-97
31927229-8	2020	LS8 cells were treated with NaF with/without HAT inhibitors MG149 (Tip60 inhibitor) and Anacardic Acid (AA; inhibits p300/CBP and PCAF).	anacardic acid	88-102	E1A binding protein p300	Mus musculus	117-121
31927229-11	2020	NaF increased active Acetyl-p300, Acetyl-CBP and phospho-Tip60 levels, suggesting that fluoride activates these HATs.	Sodium Fluoride	0-3	E1A binding protein p300	Mus musculus	28-32
32346115-1	2020	Curcumin is a naturally occurring p300-histone acetyltransferase (p300-HAT) inhibitor that suppresses cardiomyocyte hypertrophy and the development of heart failure in experimental animal models.	Curcumin	0-8	E1A binding protein p300	Mus musculus	34-64
32346115-1	2020	Curcumin is a naturally occurring p300-histone acetyltransferase (p300-HAT) inhibitor that suppresses cardiomyocyte hypertrophy and the development of heart failure in experimental animal models.	Curcumin	0-8	E1A binding protein p300	Mus musculus	34-38
32346115-4	2020	We synthesised five synthetic curcumin analogues and found that a compound we have named GO-Y030 most strongly inhibited p300-HAT activity.	Curcumin	30-38	E1A binding protein p300	Mus musculus	121-129
32346115-4	2020	We synthesised five synthetic curcumin analogues and found that a compound we have named GO-Y030 most strongly inhibited p300-HAT activity.	1,5-bis(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-one	89-96	E1A binding protein p300	Mus musculus	121-129
32346115-8	2020	A low dose of the synthetic curcumin analogue GO-Y030 effectively inhibits p300-HAT activity and markedly suppresses the development of heart failure in mice.	Curcumin	28-36	E1A binding protein p300	Mus musculus	75-79
32346115-8	2020	A low dose of the synthetic curcumin analogue GO-Y030 effectively inhibits p300-HAT activity and markedly suppresses the development of heart failure in mice.	1,5-bis(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-one	46-53	E1A binding protein p300	Mus musculus	75-79
32551019-0	2020	Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor.	CHEMBL4641354	13-21	E1A binding protein p300	Mus musculus	68-73
31906970-3	2020	Previously, we reported that lysine acetyltransferase p300/CBP acetylates tau and regulates its degradation and toxicity.	tyrosyl-lysine	29-35	E1A binding protein p300	Mus musculus	54-58
32398948-3	2020	From the screening, we found that PTEN-/- colorectal cancer cells were sensitive to anacardic acid, a p300/CBP histone acetyltransferase (HAT) inhibitor.	anacardic acid	84-98	E1A binding protein p300	Mus musculus	102-106
32398948-5	2020	Inhibition of HAT activity of p300/CBP by anacardic acid reduced the acetylation of histones at the promoter region and inhibited the transcription of Hsp70 family of proteins.	anacardic acid	42-56	E1A binding protein p300	Mus musculus	30-34
31906970-11	2020	CONCLUSIONS: We report that p300/CBP, a lysine acetyltransferase aberrantly activated in tauopathies, causes impairment in ALP, leading to excess tau secretion.	tyrosyl-lysine	40-46	E1A binding protein p300	Mus musculus	28-32
31536903-19	2019	C646 inhibited p300 expression and reduced HAT activity and aceH3 levels in asthmatic mice, thereby reducing ORMDL3 expression and relieving AHR and airway remodeling.	C646	0-4	E1A binding protein p300	Mus musculus	15-19
31371781-9	2020	In a tail vein injection pulmonary metastasis mouse model, intraperitoneal administration of garcinol (20 mg/kg) or 5-FU (20 mg/kg) significantly decreased the number of lung tumor nodules and the expression levels of Ki-67, p300, and p-Smad2/3 in lung tissues.	garcinol	93-101	E1A binding protein p300	Mus musculus	225-229
31371781-9	2020	In a tail vein injection pulmonary metastasis mouse model, intraperitoneal administration of garcinol (20 mg/kg) or 5-FU (20 mg/kg) significantly decreased the number of lung tumor nodules and the expression levels of Ki-67, p300, and p-Smad2/3 in lung tissues.	Fluorouracil	116-120	E1A binding protein p300	Mus musculus	225-229
31371781-10	2020	In conclusion, our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo, which might be related to the suppression of p300 and TGF-beta1 signaling pathways, suggesting the therapeutic potential of Garcinol for metastatic tumors.	garcinol	43-51	E1A binding protein p300	Mus musculus	157-161
31371781-10	2020	In conclusion, our study demonstrates that garcinol inhibits esophageal cancer metastasis in vitro and in vivo, which might be related to the suppression of p300 and TGF-beta1 signaling pathways, suggesting the therapeutic potential of Garcinol for metastatic tumors.	garcinol	236-244	E1A binding protein p300	Mus musculus	157-161
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Butyrates	13-21	E1A binding protein p300	Mus musculus	113-117
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Butyrates	13-21	E1A binding protein p300	Mus musculus	146-150
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Butyrates	13-21	E1A binding protein p300	Mus musculus	146-150
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Ethanol	60-67	E1A binding protein p300	Mus musculus	113-117
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Ethanol	60-67	E1A binding protein p300	Mus musculus	146-150
31654770-11	2020	Importantly, butyrate, a dietary HDAC inhibitor, attenuated ethanol-induced recruitment of HDAC1 and facilitated p300-HAT binding by enabling SP1/p300 interaction at proximal region and HNF4alpha/PGC-1alpha/p300 interactions at distal region, leading to promoter histone acetylation and enhanced CPT-1A transcription.	Ethanol	60-67	E1A binding protein p300	Mus musculus	146-150
31754401-5	2019	A highly selective catalytic p300/CBP inhibitor A-485 was identified as a potent hit in vitro and administrated to the lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced mice in vivo.	Galactosamine	144-159	E1A binding protein p300	Mus musculus	29-33
31754401-5	2019	A highly selective catalytic p300/CBP inhibitor A-485 was identified as a potent hit in vitro and administrated to the lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced mice in vivo.	Galactosamine	161-165	E1A binding protein p300	Mus musculus	29-33
31754401-0	2019	p300/CBP inhibitor A-485 alleviates acute liver injury by regulating macrophage activation and polarization.	A-485	19-24	E1A binding protein p300	Mus musculus	0-4
31754401-5	2019	A highly selective catalytic p300/CBP inhibitor A-485 was identified as a potent hit in vitro and administrated to the lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced mice in vivo.	A-485	48-53	E1A binding protein p300	Mus musculus	29-33
31602311-5	2019	We find that NDGA inhibits p300 acetyltransferase activity in vitro and suppresses acetylation of a key p300 target in histones (i.e., H3K27) in cells.	Masoprocol	13-17	E1A binding protein p300	Mus musculus	104-108
31602311-6	2019	We use the cellular thermal shift assay to uniquely demonstrate NDGA binding to p300 in cells.	Masoprocol	64-68	E1A binding protein p300	Mus musculus	80-84
31602311-7	2019	Finally, in agreement with recent findings indicating that p300 is a potent blocker of autophagy, we show that NDGA treatment induces autophagy.	Masoprocol	111-115	E1A binding protein p300	Mus musculus	59-63
31602311-8	2019	These findings identify p300 as a target of NDGA and provide mechanistic insight into its role in longevity.	Masoprocol	44-48	E1A binding protein p300	Mus musculus	24-28
31374192-8	2019	GSNO supplementation to OVX mice was able to reinstate HAT(CBP/p300) and HDAC balance through S-nitrosylation.	S-Nitrosoglutathione	0-4	E1A binding protein p300	Mus musculus	63-67
31535023-2	2019	We describe the activity of a new spirocyclic EP300/CBP inhibitor, iP300w, which inhibits the cytotoxicity of the DUX4 protein and reverses the overexpression of most DUX4 target genes, in engineered cell lines and FSHD myoblasts, as well as in an FSHD animal model.	ip300w	67-73	E1A binding protein p300	Mus musculus	46-51
31302452-1	2019	C646 is a newly discovered competitive p300/CREB-binding protein-specific inhibitor.	C646	0-4	E1A binding protein p300	Mus musculus	39-43
31602311-0	2019	Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy.	Masoprocol	25-50	E1A binding protein p300	Mus musculus	60-64
31602311-4	2019	Here, we report that NDGA is an inhibitor of the epigenetic regulator p300.	Masoprocol	21-25	E1A binding protein p300	Mus musculus	70-74
31602311-5	2019	We find that NDGA inhibits p300 acetyltransferase activity in vitro and suppresses acetylation of a key p300 target in histones (i.e., H3K27) in cells.	Masoprocol	13-17	E1A binding protein p300	Mus musculus	27-31
31535023-5	2019	This global increase in histone H3 acetylation is reversed by iP300w, highlighting the central role of EP300 and CBP in the transcriptional mechanism underlying DUX4 cytotoxicity and the translational potential of blocking this interaction.	ip300w	62-68	E1A binding protein p300	Mus musculus	103-108
30888860-2	2019	The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p300/CBP can acetylate and inactivate Akt, thus giving rise to a possible Akt-p300/CBP axis.	Cyclic AMP	60-64	E1A binding protein p300	Mus musculus	44-48
30888860-2	2019	The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p300/CBP can acetylate and inactivate Akt, thus giving rise to a possible Akt-p300/CBP axis.	Cyclic AMP	60-64	E1A binding protein p300	Mus musculus	50-54
30888860-2	2019	The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p300/CBP can acetylate and inactivate Akt, thus giving rise to a possible Akt-p300/CBP axis.	Cyclic AMP	60-64	E1A binding protein p300	Mus musculus	50-54
30888860-2	2019	The acetyltransferases, E1A binding protein p300 (p300) and cAMP response element-binding protein binding protein (CBP) are phosphorylated and activated by Akt, and p300/CBP can acetylate and inactivate Akt, thus giving rise to a possible Akt-p300/CBP axis.	Cyclic AMP	60-64	E1A binding protein p300	Mus musculus	50-54
30721949-5	2019	Frameshift mutations in mononucleotide repeat sequences within the genes Trp53, Ep300, Kmt2d, Notch1, Pten and Marcks were newly identified in the lymphomas.	mononucleotide	24-38	E1A binding protein p300	Mus musculus	80-85
30297119-0	2018	Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.	thiobarbituric acid	39-53	E1A binding protein p300	Mus musculus	76-80
30563937-10	2019	64B could thermostabilize p300, supporting direct 64B binding to p300.	Methyl (2z)-Cyano[3-(2-Fluoro-4-Methoxyphenyl)-4-Oxo-1,3-Thiazolidin-2-Ylidene]acetate	0-3	E1A binding protein p300	Mus musculus	26-30
30563937-10	2019	64B could thermostabilize p300, supporting direct 64B binding to p300.	Methyl (2z)-Cyano[3-(2-Fluoro-4-Methoxyphenyl)-4-Oxo-1,3-Thiazolidin-2-Ylidene]acetate	0-3	E1A binding protein p300	Mus musculus	65-69
30546087-8	2018	Nuclear PKA appeared to mediate the inhibitory phosphorylation of salt-inducible kinase 2 (SIK2) at serine-358 and thereby to alleviate the inhibitory phosphorylation of the CREB co-activator p300 at serine-89.	Serine	200-206	E1A binding protein p300	Mus musculus	192-196
30546087-11	2018	Together, our results indicate that high-dose GluOC triggers necroptosis through upregulation of FasL at the plasma membrane in a manner dependent of activation of CREB-p300, followed by the activation of Fas signaling in neighboring adipocytes.	gluoc	46-51	E1A binding protein p300	Mus musculus	169-173
30705122-7	2019	Administration of pharmacologic p300 inhibitor C646, but not PCAF/GCN5 inhibitor CPTH6, spared LLC tumor-bearing mice from muscle wasting.	C646	47-51	E1A binding protein p300	Mus musculus	32-36
30197302-3	2019	Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300-mediated acetylation of the mTORC1 regulator, Raptor, at K1097.	Leucine	26-29	E1A binding protein p300	Mus musculus	107-112
30197302-3	2019	Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300-mediated acetylation of the mTORC1 regulator, Raptor, at K1097.	Acetyl Coenzyme A	41-58	E1A binding protein p300	Mus musculus	107-112
30197302-3	2019	Here we describe that the Leu metabolite acetyl-coenzyme A (AcCoA) positively regulates mTORC1 activity by EP300-mediated acetylation of the mTORC1 regulator, Raptor, at K1097.	Acetyl Coenzyme A	60-65	E1A binding protein p300	Mus musculus	107-112
30297119-4	2018	DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells.	DCH36_06	0-8	E1A binding protein p300	Mus musculus	18-22
29989329-11	2018	These results showed that high ROS levels induced by iron overload polarized macrophages to the M1 subtype by enhancing p300/CBP acetyltransferase activity and promoting p53 acetylation.	Reactive Oxygen Species	31-34	E1A binding protein p300	Mus musculus	120-124
32042871-0	2019	Acetylation of H3K4, H3K9, and H3K27 mediated by p300 regulates the expression of GATA4 in cardiocytes.	H-2K(K) antigen	15-19	E1A binding protein p300	Mus musculus	49-53
32042871-6	2019	RNAi-mediated downregulation of P300 modulated the global acetylation of H3 and the acetylation of H3K4, H3K9, and H3K27 in gata4 and Tbx5 promoters.	H-2K(K) antigen	99-103	E1A binding protein p300	Mus musculus	32-36
32042871-9	2019	Taken together, our results identified that acetylation of H3K4, H3K9, and H3K27 mediated by P300 plays an important role in regulation of gata4 expression in cardiogenesis.	H-2K(K) antigen	59-63	E1A binding protein p300	Mus musculus	93-97
30130555-0	2018	Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells.	sodium arsenite	0-15	E1A binding protein p300	Mus musculus	60-64
30089269-5	2018	Inhibition of cdk4 in aged wild-type (WT) mice by a specific cdk4 inhibitor, PD-0332991, reduces C/EBPalpha-p300 complexes and eliminates hepatic steatosis.	palbociclib	77-87	E1A binding protein p300	Mus musculus	108-112
29964168-0	2018	Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2.	Butyric Acid	0-15	E1A binding protein p300	Mus musculus	79-83
29964168-11	2018	NaB inhibited HDAC activity, and increased occupancy of the transcription factor aryl hydrocarbon receptor and the co-activator P300 at the Nrf2 gene promoter.	nab	0-3	E1A binding protein p300	Mus musculus	128-132
29964168-12	2018	Further, the P300 inhibitor C646 completely abolished NaB"s efficacies.	C646	28-32	E1A binding protein p300	Mus musculus	13-17
29964168-12	2018	Further, the P300 inhibitor C646 completely abolished NaB"s efficacies.	nab	54-57	E1A binding protein p300	Mus musculus	13-17
29964168-14	2018	Other findings suggest that P300 mediates the transcriptional activation of Nrf2 by NaB.	nab	84-87	E1A binding protein p300	Mus musculus	28-32
29989329-11	2018	These results showed that high ROS levels induced by iron overload polarized macrophages to the M1 subtype by enhancing p300/CBP acetyltransferase activity and promoting p53 acetylation.	Iron	53-57	E1A binding protein p300	Mus musculus	120-124
29454793-15	2018	In HSCs, substrate stiffness activated AKT signaling via RHOA to induce phosphorylation of p300 at serine 1834; this caused p300 to translocate to the nucleus, where it up-regulated transcription of genes that increase activation of HSCs and metastasis, including CXCL12.	Serine	99-105	E1A binding protein p300	Mus musculus	91-95
29736733-8	2018	Paeonol, however, reversed the expression of P300 and HDAC3 significantly, suggesting that Paeonol may be involved in the acetylation of HMGB1 by regulating P300/HDAC3.	paeonol	0-7	E1A binding protein p300	Mus musculus	45-49
29736733-8	2018	Paeonol, however, reversed the expression of P300 and HDAC3 significantly, suggesting that Paeonol may be involved in the acetylation of HMGB1 by regulating P300/HDAC3.	paeonol	0-7	E1A binding protein p300	Mus musculus	157-161
29736733-8	2018	Paeonol, however, reversed the expression of P300 and HDAC3 significantly, suggesting that Paeonol may be involved in the acetylation of HMGB1 by regulating P300/HDAC3.	paeonol	91-98	E1A binding protein p300	Mus musculus	45-49
29736733-8	2018	Paeonol, however, reversed the expression of P300 and HDAC3 significantly, suggesting that Paeonol may be involved in the acetylation of HMGB1 by regulating P300/HDAC3.	paeonol	91-98	E1A binding protein p300	Mus musculus	157-161
29454793-15	2018	In HSCs, substrate stiffness activated AKT signaling via RHOA to induce phosphorylation of p300 at serine 1834; this caused p300 to translocate to the nucleus, where it up-regulated transcription of genes that increase activation of HSCs and metastasis, including CXCL12.	Serine	99-105	E1A binding protein p300	Mus musculus	124-128
29747586-7	2018	Interestingly, 5-hydroxymethylcytosine (5hmC) within the gene body marked cell-type-specific genes at neonatal stages and active gene-body histone mark H3K36 trimethylation declined and overlapped with cell-type-specific gene-body DNA hypomethylation and selective Pol II/p300 accumulation in adulthood.	5-hydroxymethylcytosine	15-38	E1A binding protein p300	Mus musculus	272-276
29747586-7	2018	Interestingly, 5-hydroxymethylcytosine (5hmC) within the gene body marked cell-type-specific genes at neonatal stages and active gene-body histone mark H3K36 trimethylation declined and overlapped with cell-type-specific gene-body DNA hypomethylation and selective Pol II/p300 accumulation in adulthood.	5-hydroxymethylcytosine	40-44	E1A binding protein p300	Mus musculus	272-276
29101234-5	2017	The synthesis of bile acids is known to be under the control of the circadian clock, and we observed that the time-dependent accumulation of bile acids in hepatic cells interfered with the recruitment of the co-transcriptional activator p300 to PPARalpha, thereby repressing XOD expression.	Bile Acids and Salts	17-27	E1A binding protein p300	Mus musculus	237-241
29217654-5	2018	Mice lacking either p300 or CBP in islets developed glucose intolerance attributable to impaired insulin secretion, together with reduced alpha- and beta-cell area and islet insulin content.	Glucose	52-59	E1A binding protein p300	Mus musculus	20-24
29394256-0	2018	The natural anti-tumor compound Celastrol targets a Myb-C/EBPbeta-p300 transcriptional module implicated in myeloid gene expression.	celastrol	32-41	E1A binding protein p300	Mus musculus	66-70
29394256-2	2018	Using a myeloid cell line with a stably integrated Myb-inducible reporter gene as a screening tool we have previously identified Celastrol, a natural compound with anti-tumor activity, as a potent Myb inhibitor that disrupts the interaction of Myb with the co-activator p300.	celastrol	129-138	E1A binding protein p300	Mus musculus	270-274
29394256-5	2018	By re-investigating the inhibitory potential of Celastrol we have found that Celastrol also strongly inhibits the activity of C/EBPbeta by disrupting its interaction with the Taz2 domain of p300.	celastrol	48-57	E1A binding protein p300	Mus musculus	190-194
29394256-5	2018	By re-investigating the inhibitory potential of Celastrol we have found that Celastrol also strongly inhibits the activity of C/EBPbeta by disrupting its interaction with the Taz2 domain of p300.	celastrol	77-86	E1A binding protein p300	Mus musculus	190-194
29394256-6	2018	Together with previous studies our work reveals that Celastrol independently targets Myb and C/EBPbeta by disrupting the interaction of both transcription factors with p300.	celastrol	53-62	E1A binding protein p300	Mus musculus	168-172
29394256-8	2018	We hypothesize that the ability of Celastrol to disrupt the activity of a transcriptional Myb-C/EBPbeta-p300 module might explain its promising anti-leukemic activity.	celastrol	35-44	E1A binding protein p300	Mus musculus	104-108
29101234-5	2017	The synthesis of bile acids is known to be under the control of the circadian clock, and we observed that the time-dependent accumulation of bile acids in hepatic cells interfered with the recruitment of the co-transcriptional activator p300 to PPARalpha, thereby repressing XOD expression.	Bile Acids and Salts	141-151	E1A binding protein p300	Mus musculus	237-241
28782640-0	2017	Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14.	Melatonin	10-19	E1A binding protein p300	Mus musculus	61-65
29273760-7	2017	Moreover, proliferation and ECM production in high glucose-challenged GMCs were attenuated by selective UTR antagonist, TRPC4 channel blocker, and CaMKII and CREB-binding protein/p300 inhibitors.	Glucose	51-58	E1A binding protein p300	Mus musculus	179-183
28782640-9	2017	As we know, CBP/p300 is an important class of histone acetyltransferases that acetylate histone H3K14, we found that melatonin activated the histone acetyltransferase activity of CREB-binding protein (CBP)/p300 via ERK signaling pathways.	Melatonin	117-126	E1A binding protein p300	Mus musculus	206-210
28782640-0	2017	Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14.	Lysine	101-107	E1A binding protein p300	Mus musculus	61-65
28782640-9	2017	As we know, CBP/p300 is an important class of histone acetyltransferases that acetylate histone H3K14, we found that melatonin activated the histone acetyltransferase activity of CREB-binding protein (CBP)/p300 via ERK signaling pathways.	Melatonin	117-126	E1A binding protein p300	Mus musculus	16-20
29049411-11	2017	In contrast, suppression of p300 by a p300 HAT-specific inhibitor (C646) inhibited colon cancer cell growth by suppressing COX-2 expression.	C646	67-71	E1A binding protein p300	Mus musculus	28-32
29049411-11	2017	In contrast, suppression of p300 by a p300 HAT-specific inhibitor (C646) inhibited colon cancer cell growth by suppressing COX-2 expression.	C646	67-71	E1A binding protein p300	Mus musculus	38-42
28194469-6	2017	In addition, anacardic acid abrogated histone and MEF2A acetylation and DNA-binding activity by blocking p300-HAT and PCAF-HAT activities.	anacardic acid	13-27	E1A binding protein p300	Mus musculus	105-113
28522406-0	2017	Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation.	cryptotanshinone	22-38	E1A binding protein p300	Mus musculus	99-103
28743992-3	2017	Here, we show that LPS induces endoplasmic reticulum (ER) stress and protein levels of P300, an acetyltransferase involved in glucose production.	Glucose	126-133	E1A binding protein p300	Mus musculus	87-91
28486541-2	2017	Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethally irradiated mice.	yh250	39-44	E1A binding protein p300	Mus musculus	77-81
28212548-11	2017	BCAA repressed the promoter activity of TGFbeta1R1 by inhibiting the expression of the transcription factor NFY and histone acetyltransferase p300.	Amino Acids, Branched-Chain	0-4	E1A binding protein p300	Mus musculus	142-146
28262751-2	2017	Utilizing mouse embryonic fibroblast and cancer cell line models, here we show via ChIP-seq and biochemical assays that SWI/SNF complexes are preferentially targeted to distal lineage specific enhancers and interact with p300 to modulate histone H3 lysine 27 acetylation.	Lysine	249-255	E1A binding protein p300	Mus musculus	221-225
27585400-0	2017	2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity.	2-o, 3-o desulfated heparin	0-27	E1A binding protein p300	Mus musculus	86-90
27951654-3	2016	We demonstrate that TDG interacts with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23).	Lysine	114-121	E1A binding protein p300	Mus musculus	57-61
27951654-3	2016	We demonstrate that TDG interacts with the CH3 domain of p300 to allosterically promote p300 activity to specific lysines on histone H3 (K18 and K23).	Lysine	114-121	E1A binding protein p300	Mus musculus	88-92
26980118-5	2016	On the basis of these findings, we developed a protocol to differentiate mESCs toward insulin-producing cells consisting of sequential exposure to DETA-NO, valproic acid, and P300 inhibitor (C646) to enhance Pdx1 expression and a final maturation step of culture in suspension to form cell aggregates.	C646	191-195	E1A binding protein p300	Mus musculus	175-179
27904663-8	2016	The expression of the histone acetyltransferase p300/CBP-associated factor, a regulator of inflammatory molecules, was significantly inhibited by efonidipine.	efonidipine	146-157	E1A binding protein p300	Mus musculus	48-52
27768872-5	2016	Cell-free transcription assays demonstrated that H3S28ph directly promotes p300/CBP-dependent transcription.	h3s28ph	49-56	E1A binding protein p300	Mus musculus	75-79
26718586-0	2016	The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.	C646	45-49	E1A binding protein p300	Mus musculus	30-34
26867564-10	2016	In mouse liver after BDL NF-kappaB recruitment to Ostalpha and Ostbeta promoters was associated with increased binding of the potent coactivator cAMP response element binding protein (CREB)-binding protein (CBP)/p300 to the NF-kappaBE and depletion of CBP/p300 at the FXR element.	Cyclic AMP	145-149	E1A binding protein p300	Mus musculus	212-216
26718496-12	2016	These data indicate that glucose-induced EndMT in vivo and in vitro in the hearts of diabetic mice is possibly mediated by miR-200b and p300.	Glucose	25-32	E1A binding protein p300	Mus musculus	136-140
27297729-11	2016	Mechanistically, TSA reduced expression of Nox4 via ubiquitination of p300- histone acetyltransferase (p300-HAT).	trichostatin A	17-20	E1A binding protein p300	Mus musculus	70-74
27297729-11	2016	Mechanistically, TSA reduced expression of Nox4 via ubiquitination of p300- histone acetyltransferase (p300-HAT).	trichostatin A	17-20	E1A binding protein p300	Mus musculus	103-107
27297729-17	2016	Trichostatin A reduces Nox4 expression and angiogenesis via inhibition of the p300-HAT-dependent pathway.	trichostatin A	0-14	E1A binding protein p300	Mus musculus	78-82
26758684-10	2016	Finally, the transcriptional coregulator p300 was recruited to all three GBRs upon Dex treatment.	Dexamethasone	83-86	E1A binding protein p300	Mus musculus	41-45
26758684-11	2016	The reduction of p300 expression decreased FoxO3 gene expression and Dex-stimulated interaction between distinct genomic regions of FoxO3 gene identified by 3C.	Dexamethasone	69-72	E1A binding protein p300	Mus musculus	17-21
26718586-5	2016	Among the few histone acetyltransferase inhibitors described, C646 is one of the most potent (Ki of 0.4muM for histone acetyltransferase p300).	C646	62-66	E1A binding protein p300	Mus musculus	111-141
26806835-7	2016	The involvement of histone acetylation in glucose-stimulated TXNIP expression was confirmed by reversing or enhancing acetylation using the histone acetyltransferase p300 inhibitor C646 or the histone deacetylase inhibitor trichostatin A.	Glucose	42-49	E1A binding protein p300	Mus musculus	166-170
26552350-0	2015	Regulation of cyclic adenosine monophosphate response element binding protein on renin expression in kidney via complex cyclic adenosine monophosphate response element-binding-protein-binding protein/P300 recruitment.	Cyclic AMP	14-44	E1A binding protein p300	Mus musculus	200-204
26517526-3	2015	Luteolin was found to inhibit p300 acetyltransferase with competitive binding to the acetyl CoA binding site.	Acetyl Coenzyme A	85-95	E1A binding protein p300	Mus musculus	30-34
26552350-0	2015	Regulation of cyclic adenosine monophosphate response element binding protein on renin expression in kidney via complex cyclic adenosine monophosphate response element-binding-protein-binding protein/P300 recruitment.	Cyclic AMP	120-150	E1A binding protein p300	Mus musculus	200-204
26390242-6	2015	Acetyltransferase p300-induced tau acetylation is inhibited by salsalate and salicylate, which enhance tau turnover and reduce tau levels.	salicylsalicylic acid	63-72	E1A binding protein p300	Mus musculus	18-22
26390242-6	2015	Acetyltransferase p300-induced tau acetylation is inhibited by salsalate and salicylate, which enhance tau turnover and reduce tau levels.	Salicylates	77-87	E1A binding protein p300	Mus musculus	18-22
26390242-7	2015	In the PS19 transgenic mouse model of FTD, administration of salsalate after disease onset inhibited p300 activity, lowered levels of total tau and tau acetylated at K174, rescued tau-induced memory deficits and prevented hippocampal atrophy.	salicylsalicylic acid	61-70	E1A binding protein p300	Mus musculus	101-105
26001729-0	2015	Histone acetyltransferase p300 is induced by p38MAPK after photodynamic therapy: the therapeutic response is increased by the p300HAT inhibitor anacardic acid.	anacardic acid	144-158	E1A binding protein p300	Mus musculus	0-30
26001729-0	2015	Histone acetyltransferase p300 is induced by p38MAPK after photodynamic therapy: the therapeutic response is increased by the p300HAT inhibitor anacardic acid.	anacardic acid	144-158	E1A binding protein p300	Mus musculus	126-133
26001729-3	2015	In this study, we found that activated p38MAPK could significantly up-regulate the activity and expression of histone acetyltransferase p300 (p300HAT) in A375 and C26 cells treated with ALA-and chlorin e6 (Ce6)-mediated photodynamic treatment.	Alanine	186-189	E1A binding protein p300	Mus musculus	110-140
26001729-3	2015	In this study, we found that activated p38MAPK could significantly up-regulate the activity and expression of histone acetyltransferase p300 (p300HAT) in A375 and C26 cells treated with ALA-and chlorin e6 (Ce6)-mediated photodynamic treatment.	Alanine	186-189	E1A binding protein p300	Mus musculus	142-149
26001729-3	2015	In this study, we found that activated p38MAPK could significantly up-regulate the activity and expression of histone acetyltransferase p300 (p300HAT) in A375 and C26 cells treated with ALA-and chlorin e6 (Ce6)-mediated photodynamic treatment.	phytochlorin	206-209	E1A binding protein p300	Mus musculus	110-140
26001729-3	2015	In this study, we found that activated p38MAPK could significantly up-regulate the activity and expression of histone acetyltransferase p300 (p300HAT) in A375 and C26 cells treated with ALA-and chlorin e6 (Ce6)-mediated photodynamic treatment.	phytochlorin	206-209	E1A binding protein p300	Mus musculus	142-149
26001729-4	2015	A colony-formation assay showed that PDT-induced cytotoxicity was dramatically elevated in the presence of the p300HAT inhibitor anacardic acid (AA).	anacardic acid	129-143	E1A binding protein p300	Mus musculus	111-118
26317696-8	2015	Bnip3-TG mice underwent age-dependent ventricular dilation and heart failure that was partially prevented by p300 inhibition with curcumin.	Curcumin	130-138	E1A binding protein p300	Mus musculus	109-113
26100016-2	2015	In this paper, we examined these mechanisms using transgenic mice expressing a dominant negative p300 molecule (dnp300).	dnp300	112-118	E1A binding protein p300	Mus musculus	97-101
25797917-12	2015	The over-expression of NKX2.5, beta-MHC, Cx43 mediated by p300 and PCAF may be critical mechanisms of alcohol-induced cardiac hypertrophy.	Alcohols	102-109	E1A binding protein p300	Mus musculus	58-62
25349198-8	2015	Estradiol suppressed collagen production by dampening the expression and binding activity of MRTF-A and interfering with the interaction between p300 and WDR5 in renal epithelial cells.	Estradiol	0-9	E1A binding protein p300	Mus musculus	145-149
25446993-0	2015	Novel curcumin analog C66 prevents diabetic nephropathy via JNK pathway with the involvement of p300/CBP-mediated histone acetylation.	Curcumin	6-14	E1A binding protein p300	Mus musculus	96-100
25972198-7	2015	Previously, we reported that Cr(VI) inhibits MT transcription by preventing the zinc-dependent formation of a complex of metal response element-binding transcription factor-1 (MTF-1) and the co-activator p300.	chromium hexavalent ion	29-35	E1A binding protein p300	Mus musculus	204-208
25664930-3	2015	Broader in vitro selectivity profiling shows that PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300, whereas PU141 is selective toward CBP and p300.	PU139	50-55	E1A binding protein p300	Mus musculus	78-82
25664930-3	2015	Broader in vitro selectivity profiling shows that PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300, whereas PU141 is selective toward CBP and p300.	PU139	50-55	E1A binding protein p300	Mus musculus	168-172
25446101-8	2015	Chromatin immunoprecipitation assay showed that overexpression of ATF3 blocked both binding of PPARgamma and recruitment of p300 to PPRE on aP2 promoter induced by rosiglitazone treatment in 3T3-L1 cells.	Rosiglitazone	164-177	E1A binding protein p300	Mus musculus	124-128
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	veratric acid	152-165	E1A binding protein p300	Mus musculus	19-23
25352364-5	2015	The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	222-230	E1A binding protein p300	Mus musculus	19-23
25406541-6	2014	FINDINGS: Here we report that curcumin (CUR), a naturally occurring compound endowed with p300/CREB-binding protein HAT inhibitory activity, is able to induce a drastic down-regulation of the mGlu2 receptor in the mouse spinal cord after systemic administration together with a marked hypoacetylation of histones H3 and H4 in dorsal root ganglia (DRG).	Curcumin	30-38	E1A binding protein p300	Mus musculus	90-94
25016014-8	2014	Intestinal accumulated bile acids interfered with recruitment of co-transcriptional activator CREB-binding protein/p300 on the promoter region of Slc15a1 gene, thereby suppressing PPARalpha-mediated transactivation of Slc15a1.	Bile Acids and Salts	23-33	E1A binding protein p300	Mus musculus	115-119
25154413-2	2014	A histone/protein acetyltransferase (HAT), p300, was recently found to be important for Treg function and stability, but further insights into the mechanisms by which p300 or other HATs affect Treg biology are needed.	treg	88-92	E1A binding protein p300	Mus musculus	43-47
25154413-2	2014	A histone/protein acetyltransferase (HAT), p300, was recently found to be important for Treg function and stability, but further insights into the mechanisms by which p300 or other HATs affect Treg biology are needed.	treg	88-92	E1A binding protein p300	Mus musculus	167-171
25335984-12	2014	CONCLUSIONS: These data indicate glucose-induced EndMT in vitro and in vivo is possibly mediated through TGFbeta and regulated by miR-200b and p300.	Glucose	33-40	E1A binding protein p300	Mus musculus	143-147
24796935-0	2014	Expression of histone deacetylase-1 and p300 in aristolochic acid nephropathy models.	aristolochic acid I	48-65	E1A binding protein p300	Mus musculus	40-44
24451378-9	2014	Our results demonstrate that trichostatin A and MGCD0103 enhanced Npr1 gene expression through inhibition of HDAC1/2 and increased both acetylation of histones (H3-K9/14, H4-K12) and Sp1 by p300, and their recruitment to Npr1 promoter.	trichostatin A	29-43	E1A binding protein p300	Mus musculus	190-194
25175164-4	2014	The nuclear localization and interaction between transcriptional co-activator p300 and NF-kappaB p50/p65 and their binding to COX-2 promoter were analyzed after treatment with CS-6.	1-hexene	176-180	E1A binding protein p300	Mus musculus	78-82
25175164-8	2014	RESULTS: Gamabufotalin (CS-6) strongly suppressed COX-2 expression by inhibiting the phosphorylation of IKKbeta via targeting the ATP-binding site, thereby abrogating NF-kappaB binding and p300 recruitment to COX-2 promoter.	gamabufotalin	9-22	E1A binding protein p300	Mus musculus	189-193
25175164-8	2014	RESULTS: Gamabufotalin (CS-6) strongly suppressed COX-2 expression by inhibiting the phosphorylation of IKKbeta via targeting the ATP-binding site, thereby abrogating NF-kappaB binding and p300 recruitment to COX-2 promoter.	1-hexene	24-28	E1A binding protein p300	Mus musculus	189-193
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	114-118	E1A binding protein p300	Mus musculus	109-113
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	114-118	E1A binding protein p300	Mus musculus	109-113
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	114-118	E1A binding protein p300	Mus musculus	109-113
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	204-208	E1A binding protein p300	Mus musculus	109-113
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	204-208	E1A binding protein p300	Mus musculus	109-113
24451378-8	2014	Furthermore, HDACi attenuated the interaction of Sp1 with HDAC1/2 and promoted Sp1 association with p300 and p300/cAMP-binding protein-associated factor; it also promoted the recruitment of p300 and p300/cAMP-binding protein-associated factor to the Npr1 promoter.	Cyclic AMP	204-208	E1A binding protein p300	Mus musculus	109-113
25101666-7	2014	Binding of P300, CBP, PCAF, SRC1, but not GCN5, were increased on the Gata4 promoter relative to the saline treated group.	Sodium Chloride	101-107	E1A binding protein p300	Mus musculus	11-15
25101666-11	2014	CONCLUSIONS: Our results suggest that P300 and PCAF may be critical regulatory factors that mediate Gata4 over-expression induced by ethanol exposure.	Ethanol	133-140	E1A binding protein p300	Mus musculus	38-42
25101666-13	2014	Anacardic acid may thus protect against ethanol-induced Gata4, alpha-MHC, cTnT over-expression by inhibiting the binding of P300 and PCAF to the promoter region of these genes.	anacardic acid	0-14	E1A binding protein p300	Mus musculus	124-128
25101666-13	2014	Anacardic acid may thus protect against ethanol-induced Gata4, alpha-MHC, cTnT over-expression by inhibiting the binding of P300 and PCAF to the promoter region of these genes.	Ethanol	40-47	E1A binding protein p300	Mus musculus	124-128
25051175-8	2014	Furthermore, curcumin, a natural selective inhibitor of p300 in HATs, significantly suppressed the expression of PS1 and BACE1 through inhibition of H3 acetylation in their promoter regions in N2a/APPswe cells.	Curcumin	13-21	E1A binding protein p300	Mus musculus	56-60
24892905-10	2014	CMZ co-treatment suppressed ethanol-induced oxidative stress, overproduction of tumor necrosis alpha (TNF-alpha), and decrease of protein levels of the PPAR-alpha co-activators including p300 and deacetylated PGC1-alpha.	Ethanol	28-35	E1A binding protein p300	Mus musculus	187-191
24714214-5	2014	A combination of ATRA-NaBu promoted recruitment of activator-complex containing E26 transformation-specific 1, retinoic acid receptor alpha, and HATs (p300 and p300/cAMP response element-binding protein-binding protein-associated factor) at the Npr1 promoter, and significantly increased renal NPRA expression, GC activity, and cGMP levels.	atra-nabu	17-26	E1A binding protein p300	Mus musculus	151-155
24714214-5	2014	A combination of ATRA-NaBu promoted recruitment of activator-complex containing E26 transformation-specific 1, retinoic acid receptor alpha, and HATs (p300 and p300/cAMP response element-binding protein-binding protein-associated factor) at the Npr1 promoter, and significantly increased renal NPRA expression, GC activity, and cGMP levels.	atra-nabu	17-26	E1A binding protein p300	Mus musculus	160-164
24714214-5	2014	A combination of ATRA-NaBu promoted recruitment of activator-complex containing E26 transformation-specific 1, retinoic acid receptor alpha, and HATs (p300 and p300/cAMP response element-binding protein-binding protein-associated factor) at the Npr1 promoter, and significantly increased renal NPRA expression, GC activity, and cGMP levels.	Cyclic GMP	328-332	E1A binding protein p300	Mus musculus	160-164
24451378-9	2014	Our results demonstrate that trichostatin A and MGCD0103 enhanced Npr1 gene expression through inhibition of HDAC1/2 and increased both acetylation of histones (H3-K9/14, H4-K12) and Sp1 by p300, and their recruitment to Npr1 promoter.	mocetinostat	48-56	E1A binding protein p300	Mus musculus	190-194
24379407-9	2014	In addition, inhibition of histone acetyltransferase activity of P300 significantly decreased hepatic Foxo1 mRNA and FOXO1 protein levels in fasted mice, as well as fasting blood glucose levels.	Glucose	179-186	E1A binding protein p300	Mus musculus	65-69
24379407-10	2014	By characterization of Foxo1 gene promoter, P300 regulates the Foxo1 gene expression through the binding to tandem cAMP-response element sites in the proximal promoter region of Foxo1 gene.	Cyclic AMP	115-119	E1A binding protein p300	Mus musculus	44-48
23632743-8	2013	In addition, curcumin selectively suppressed AdBMP2-induced expression of HAT p300, but not HAT GCN5 in H9c2 cells.	Curcumin	13-21	E1A binding protein p300	Mus musculus	78-82
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Glutamic Acid	64-77	E1A binding protein p300	Mus musculus	27-31
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Glutamic Acid	79-82	E1A binding protein p300	Mus musculus	27-31
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	88-101	E1A binding protein p300	Mus musculus	27-31
24265312-1	2014	CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic acid (Asp)-tail 2 (Cited2) was recently shown to be essential for gluconeogenesis in the adult mouse.	Aspartic Acid	103-106	E1A binding protein p300	Mus musculus	27-31
23632743-8	2013	In addition, curcumin selectively suppressed AdBMP2-induced expression of HAT p300, but not HAT GCN5 in H9c2 cells.	adbmp2	45-51	E1A binding protein p300	Mus musculus	78-82
23632743-9	2013	The data indicated that inhibition of histone H3 acetylation with curcumin diminished BMP2-induced expression of GATA4 and MEF2C, suggesting that p300-mediated histone acetylation was essential for the regulation of GATA4 and MEF2C by BMP2 in H9c2 cells.	Curcumin	66-74	E1A binding protein p300	Mus musculus	146-150
24236240-8	2013	This study suggests that the probable mechanism of action of curcumin is via the reduction of p300 HAT activity.	Curcumin	61-69	E1A binding protein p300	Mus musculus	94-98
23891677-0	2013	Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving It from p65.	ethyl pyruvate	56-70	E1A binding protein p300	Mus musculus	86-90
23804093-2	2013	Here we present a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.	Glucose	121-128	E1A binding protein p300	Mus musculus	89-93
23770612-0	2013	Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage.	Glycogen	74-82	E1A binding protein p300	Mus musculus	51-55
23770612-3	2013	In this report, we show that depletion of hepatic p300 reduces glycogen synthesis, decreases hepatic glycogen storage, and leads to relative hypoglycemia.	Glycogen	63-71	E1A binding protein p300	Mus musculus	50-54
23770612-3	2013	In this report, we show that depletion of hepatic p300 reduces glycogen synthesis, decreases hepatic glycogen storage, and leads to relative hypoglycemia.	Glycogen	101-109	E1A binding protein p300	Mus musculus	50-54
23770612-5	2013	However, p300, which is closely related to CBP, lacks the corresponding S436 phosphorylation site found on CBP.	Acid Green 27	72-76	E1A binding protein p300	Mus musculus	9-13
23770612-7	2013	Our study demonstrates the important and unique role of p300 in glycogen synthesis through maintaining basal gluconeogenesis.	Glycogen	64-72	E1A binding protein p300	Mus musculus	56-60
23804093-2	2013	Here we present a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.	Carbon	135-141	E1A binding protein p300	Mus musculus	89-93
23625921-10	2013	Therefore, the results of the present study suggest that the glucose metabolite, ManNAc, induces switching from the inactive state by Ogt-Sirt1 to the active state by Mgea5, p300, and CBP at the Hcrt gene locus.	Glucose	61-68	E1A binding protein p300	Mus musculus	174-178
23625921-10	2013	Therefore, the results of the present study suggest that the glucose metabolite, ManNAc, induces switching from the inactive state by Ogt-Sirt1 to the active state by Mgea5, p300, and CBP at the Hcrt gene locus.	N-acetylmannosamine	81-87	E1A binding protein p300	Mus musculus	174-178
23762415-4	2013	The histone acetyltransferase (HAT) coactivator p300, but not other HATs, acetylates Gli2 at the conserved lysine K757 thus inhibiting Hh target gene expression.	lysine k757	107-118	E1A binding protein p300	Mus musculus	48-52
22523253-3	2012	The cAMP pathway is important for renin synthesis and release: the transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter.	Cyclic AMP	4-8	E1A binding protein p300	Mus musculus	190-194
23499441-5	2013	The underlying mechanism of the hepatic steatosis in old wild-type (WT) mice and in young S193D mice includes increased amounts of tripartite p300-C/EBPalpha/beta complexes that activate promoters of five genes that drive triglyceride synthesis.	tripartite	131-141	E1A binding protein p300	Mus musculus	142-146
23499441-5	2013	The underlying mechanism of the hepatic steatosis in old wild-type (WT) mice and in young S193D mice includes increased amounts of tripartite p300-C/EBPalpha/beta complexes that activate promoters of five genes that drive triglyceride synthesis.	Triglycerides	222-234	E1A binding protein p300	Mus musculus	142-146
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Curcumin	21-29	E1A binding protein p300	Mus musculus	40-44
22890222-5	2012	Further we show that curcumin inhibited p300 activity in the TREM-1 promoter region leading to hypoacetylation of histone 3 and 4 in the lysine residues.	Lysine	137-143	E1A binding protein p300	Mus musculus	40-44
22120716-2	2012	We identify here a specific novel property of Notch3 that is acetylated and deacetylated at lysines 1692 and 1731 by p300 and HDAC1, respectively, a balance impaired by HDAC inhibitors (HDACi) that favor hyperacetylation.	Lysine	92-99	E1A binding protein p300	Mus musculus	117-121
23316072-6	2013	Activation of beta-catenin/p300-dependent gene expression using the compound ICG-001 accelerated epithelial repair in vitro and in murine models.	Indocyanine Green	77-80	E1A binding protein p300	Mus musculus	27-31
23297412-0	2013	Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.	Resveratrol	0-11	E1A binding protein p300	Mus musculus	110-114
23297412-4	2013	In cultured cardiomyocytes, cardiomyocyte hypertrophy induced by the alpha(1)-agonist phenylephrine was inhibited by the overexpression of SIRT1 as well as resveratrol, both of which down-regulated p300 protein levels but not p300 mRNA levels.	Resveratrol	156-167	E1A binding protein p300	Mus musculus	198-202
23297412-4	2013	In cultured cardiomyocytes, cardiomyocyte hypertrophy induced by the alpha(1)-agonist phenylephrine was inhibited by the overexpression of SIRT1 as well as resveratrol, both of which down-regulated p300 protein levels but not p300 mRNA levels.	Resveratrol	156-167	E1A binding protein p300	Mus musculus	226-230
23297412-6	2013	We found that SIRT1 induced p300 down-regulation via the ubiquitin-proteasome pathway by deacetylation of lysine residues for ubiquitination.	Lysine	106-112	E1A binding protein p300	Mus musculus	28-32
22815486-5	2012	p300(G422S) and hepatic-deleted p300 mice exhibited significant lower blood glucose levels in the fasted and post-prandial states, indicating a role for p300 in maintaining basal HGP.	Glucose	76-83	E1A binding protein p300	Mus musculus	0-4
22815486-5	2012	p300(G422S) and hepatic-deleted p300 mice exhibited significant lower blood glucose levels in the fasted and post-prandial states, indicating a role for p300 in maintaining basal HGP.	Glucose	76-83	E1A binding protein p300	Mus musculus	32-36
22815486-5	2012	p300(G422S) and hepatic-deleted p300 mice exhibited significant lower blood glucose levels in the fasted and post-prandial states, indicating a role for p300 in maintaining basal HGP.	Glucose	76-83	E1A binding protein p300	Mus musculus	32-36
22761414-1	2012	Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs.	Glutamic Acid	49-62	E1A binding protein p300	Mus musculus	12-16
22761414-1	2012	Cited2 (CBP/p300-interacting transactivator with glutamic acid (E)/aspartic acid (D)-rich tail 2) is a transcriptional modulator critical for the development of multiple organs.	Aspartic Acid	67-80	E1A binding protein p300	Mus musculus	12-16
22523253-3	2012	The cAMP pathway is important for renin synthesis and release: the transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter.	Cyclic AMP	118-122	E1A binding protein p300	Mus musculus	190-194
22523253-3	2012	The cAMP pathway is important for renin synthesis and release: the transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter.	Cyclic AMP	118-122	E1A binding protein p300	Mus musculus	190-194
23272250-7	2012	Quantitative chromatin immunoprecipitation-PCR (ChIP-qPCR) shows that treatment with valproic acid (VPA) increases the recruitment of Kdm5a and Kdm6a to proximal promoter (PP) and proximal enhancer (PE) of Pou5f1 whereas enrichment of Ep300 and Kdm6b was seen in PP but not PE of Pou5f1 promoter.	Valproic Acid	85-98	E1A binding protein p300	Mus musculus	235-240
21938722-6	2012	In addition, the targeting of p300 in combination with a differential enrichment of Brm to Brg1 change at the distal promoter region of the gene is induced under RA treatment.	Tretinoin	162-164	E1A binding protein p300	Mus musculus	30-34
21503886-2	2012	Recently, we have shown that nicotinamide effectively inhibits the growth and progression of bladder tumors by up-regulating RUNX3 and p300 expression.	Niacinamide	29-41	E1A binding protein p300	Mus musculus	135-139
22409325-5	2012	Our study observes that AcEGCG treatment inhibited histone 3 lysine 9 (H3K9) acetylation but did not affect histone acetyltransferase (HAT) activity and acetyl- CREB-binding protein (CBP)/p300 levels.	EGCG Octaacetate	24-30	E1A binding protein p300	Mus musculus	188-192
22665973-1	2012	PURPOSE: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators.	Glutamic Acid	59-72	E1A binding protein p300	Mus musculus	21-25
22665973-1	2012	PURPOSE: Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a member of a new family of transcriptional modulators.	Aspartic Acid	81-94	E1A binding protein p300	Mus musculus	21-25
23272250-7	2012	Quantitative chromatin immunoprecipitation-PCR (ChIP-qPCR) shows that treatment with valproic acid (VPA) increases the recruitment of Kdm5a and Kdm6a to proximal promoter (PP) and proximal enhancer (PE) of Pou5f1 whereas enrichment of Ep300 and Kdm6b was seen in PP but not PE of Pou5f1 promoter.	Valproic Acid	100-103	E1A binding protein p300	Mus musculus	235-240
21593332-4	2011	Our results also demonstrate that the HAT p300 is highly expressed within pyramidal neurons of the ILPFC and that the small-molecule p300-specific inhibitor (C646) infused into the ILPFC immediately after weak extinction training enhances the consolidation of fear extinction memory.	C646	158-162	E1A binding protein p300	Mus musculus	42-46
21389279-4	2011	Conversely, increased HAT activity via transfection of either wild-type (WT) p300 or WT CBP repressed FOXO activation in vivo in response to muscle disuse, and in C2C12 cells in response to dexamethasone and acute starvation.	Dexamethasone	190-203	E1A binding protein p300	Mus musculus	77-81
23029429-5	2012	After having identified the acetyltransferase p300 among several acetyltransferases to be associated with Rb2/p130 during S-phase in NIH3T3 cells in vivo, we used this enzyme and the CDK4 protein kinase for in vitro modification of a variety of full length Rb2/p130 and truncated versions with mutations in the acetylatable lysine residues 1079, 128 and 130.	Lysine	324-330	E1A binding protein p300	Mus musculus	46-50
22312446-9	2012	CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung.	Cesium	0-2	E1A binding protein p300	Mus musculus	72-76
22312446-9	2012	CS extract/CS promotes the direct interaction of MSK1 with RelA/p65 and p300 in epithelial cells and in mouse lung.	Cesium	11-13	E1A binding protein p300	Mus musculus	72-76
21986529-8	2011	In addition, chromatin immunoprecipitation analysis demonstrated that both tunicamycin treatment and ATF3 overexpression inhibited the recruitment of p300 to PDX-1 on the insulin promoter in MIN6N8 cells.	Tunicamycin	75-86	E1A binding protein p300	Mus musculus	150-154
21593332-4	2011	Our results also demonstrate that the HAT p300 is highly expressed within pyramidal neurons of the ILPFC and that the small-molecule p300-specific inhibitor (C646) infused into the ILPFC immediately after weak extinction training enhances the consolidation of fear extinction memory.	C646	158-162	E1A binding protein p300	Mus musculus	133-137
21372295-0	2011	Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system.	Reactive Oxygen Species	92-115	E1A binding protein p300	Mus musculus	211-215
21518915-0	2011	Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.	lysine-4 trimethylated histone h3	27-60	E1A binding protein p300	Mus musculus	105-109
21257198-8	2011	Inhibiting p300-dependent beta-catenin signals with the small molecule IQ1 facilitated further expansion of CPCs.	cytidylyl-(3'-5')-cytidine	108-112	E1A binding protein p300	Mus musculus	11-15
21372295-11	2011	Further analysis revealed that PYK2/ROS-mediated p21Cip1/Ets-1 activation upregulated the transcription of the MCP-1 gene in collaboration with p300 transcription coactivator.	Reactive Oxygen Species	36-39	E1A binding protein p300	Mus musculus	144-148
21372295-12	2011	CONCLUSIONS: PYK2 is a key tyrosine kinase activated by high cholesterol exposure, which causes ROS-mediated TNFalpha release and induces TNFalpha-dependent expression of proinflammatory molecules via the p21Cip1/Ets-1/p300 transcription system.	Cholesterol	61-72	E1A binding protein p300	Mus musculus	219-223
21372295-12	2011	CONCLUSIONS: PYK2 is a key tyrosine kinase activated by high cholesterol exposure, which causes ROS-mediated TNFalpha release and induces TNFalpha-dependent expression of proinflammatory molecules via the p21Cip1/Ets-1/p300 transcription system.	Reactive Oxygen Species	96-99	E1A binding protein p300	Mus musculus	219-223
21292824-6	2011	GH also induced the occupancy of phosphorylated C/EBPbeta and p300 on Cyr61, Btg2, and Socs3 at predicted C/EBP-cAMP response element-binding protein motifs in their promoters.	Cyclic AMP	112-116	E1A binding protein p300	Mus musculus	62-66
21467744-3	2011	Previously, we had reported that Zn induced the formation of a co-activator complex containing metal response element-binding transcription factor-1 (MTF-1) and the histone acetyltransferase (HAT), p300, which plays an essential role in the activation of MT-1 transcription.	Zinc	33-35	E1A binding protein p300	Mus musculus	198-202
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Chromium	31-33	E1A binding protein p300	Mus musculus	131-135
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	47-49	E1A binding protein p300	Mus musculus	131-135
21467744-4	2011	In addition, we had shown that Cr(VI) inhibits Zn-induced MT-1 transcription by preventing the Zn-dependent formation of the MTF-1-p300 complex.	Zinc	95-97	E1A binding protein p300	Mus musculus	131-135
20947830-7	2010	Overexpression of FoxO1(3A/LXXAA), which cannot interact with Sirt1, or p300, a histone acetylase, increased acetylation of FoxO1 and inhibited GD-induced autophagy.	Gadolinium	144-146	E1A binding protein p300	Mus musculus	72-76
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	E1A binding protein p300	Mus musculus	14-18
21034749-11	2010	SIGNIFICANCE: p300 interacts with cardiac-specific genes, GATA4, Nkx2.5 and Mef2c, and inhibition of p300-HAT by curcumin down-regulates their expression through the inhibition of histone H3 acetylation in the promoter regions.	Curcumin	113-121	E1A binding protein p300	Mus musculus	101-105
21220944-2	2011	We have shown previously that CBP and p300 double knockout mutations in mouse embryonic fibroblasts (dKO MEFs) result in mixed effects on cAMP-inducible gene expression, with many CREB target genes requiring CBP/p300 for full expression, while others are unaffected or expressed better in their absence.	Cyclic AMP	138-142	E1A binding protein p300	Mus musculus	38-42
21220944-4	2011	We found that while retinoic acid-inducible gene expression tends to be uniformly dependent on CBP/p300, dsRNA- and serum-inducible genes displayed non-uniform requirements for CBP/p300, with the dsRNA-inducible expression of Ifnb1 (interferon-beta) being particularly dependent on CBP/p300.	Tretinoin	20-33	E1A binding protein p300	Mus musculus	99-103
21220944-6	2011	As with cAMP-responsive CREB targets, we propose that the signal-responsive recruitment of CBP and p300 does not necessarily indicate a requirement for these coactivators at a locus.	Cyclic AMP	8-12	E1A binding protein p300	Mus musculus	99-103
21084751-6	2010	In cultured mouse hepatocytes, we showed that glucose-activated p300 acetylated ChREBP on Lys672 and increased its transcriptional activity by enhancing its recruitment to its target gene promoters.	Glucose	46-53	E1A binding protein p300	Mus musculus	64-68
20817729-6	2010	Tandem mass spectrometry and mutagenesis studies revealed that SREBP-1c is acetylated by p300 at Lys-289 and Lys-309.	Lysine	97-100	E1A binding protein p300	Mus musculus	89-93