PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2555773-1	1989	Topoisomerase I cleavage sites have been mapped in vivo on the Hsp70 heat shock gene of Drosophila melanogaster cells using the drug camptothecin.	Camptothecin	133-145	Topoisomerase 1	Drosophila melanogaster	0-15
2555773-5	1989	Inhibition of heat-induced Hsp70 transcription by either Actinomycin D (Act D) or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) inhibited topoisomerase I cleavage except at the 5" and to a lesser extent the 3" end of the gene.	Dactinomycin	57-70	Topoisomerase 1	Drosophila melanogaster	147-162
2555773-5	1989	Inhibition of heat-induced Hsp70 transcription by either Actinomycin D (Act D) or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) inhibited topoisomerase I cleavage except at the 5" and to a lesser extent the 3" end of the gene.	Dichlororibofuranosylbenzimidazole	82-130	Topoisomerase 1	Drosophila melanogaster	147-162
2555773-5	1989	Inhibition of heat-induced Hsp70 transcription by either Actinomycin D (Act D) or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) inhibited topoisomerase I cleavage except at the 5" and to a lesser extent the 3" end of the gene.	Dichlororibofuranosylbenzimidazole	132-135	Topoisomerase 1	Drosophila melanogaster	147-162
2548490-2	1989	Inhibition of ribosomal RNA synthesis and processing by 5-fluorouridine or of general RNA synthesis by camptothecin, an inhibitor of topoisomerase I, does not affect the methylation pattern of core histones.	Camptothecin	103-115	Topoisomerase 1	Drosophila melanogaster	133-148
2819725-3	1987	Camptothecin stabilizes the topoisomerase I-DNA covalent intermediate that forms during the relaxation of torsionally strained DNA.	Camptothecin	0-12	Topoisomerase 1	Drosophila melanogaster	28-43
2819731-3	1987	Recent studies have demonstrated that camptothecin interferes with the DNA breakage and rejoining activity of the enzyme DNA topoisomerase I and stabilizes a cleavable complex between this enzyme and DNA.	Camptothecin	38-50	Topoisomerase 1	Drosophila melanogaster	125-140
23316441-3	2013	In this study, we focused on camptothecin and its derivatives, topotecan and irinotecan, which are type I topoisomerase inhibitors that create DNA double-strand breaks in rapidly dividing cells.	Camptothecin	29-41	Topoisomerase 1	Drosophila melanogaster	99-119
3031452-0	1987	Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin.	Camptothecin	134-146	Topoisomerase 1	Drosophila melanogaster	25-40
3031452-1	1987	Camptothecin stabilizes the topoisomerase I-DNA covalent intermediate that forms during the relaxation of torsionally strained DNA.	Camptothecin	0-12	Topoisomerase 1	Drosophila melanogaster	28-43
23316441-3	2013	In this study, we focused on camptothecin and its derivatives, topotecan and irinotecan, which are type I topoisomerase inhibitors that create DNA double-strand breaks in rapidly dividing cells.	Topotecan	63-72	Topoisomerase 1	Drosophila melanogaster	99-119
23316441-3	2013	In this study, we focused on camptothecin and its derivatives, topotecan and irinotecan, which are type I topoisomerase inhibitors that create DNA double-strand breaks in rapidly dividing cells.	Irinotecan	77-87	Topoisomerase 1	Drosophila melanogaster	99-119
16834570-4	2006	We have shown that the Kep1 protein is phosphorylated in ovaries induced to undergo apoptosis following treatment with the topoisomerase I inhibitor camptothecin.	Camptothecin	149-161	Topoisomerase 1	Drosophila melanogaster	123-138
1312349-1	1992	We have compared topoisomerase I and II cleavage sites on the actin 5C and 57A genes and the hsp70 genes in Drosophila Kc cells using the inhibitors camptothecin (topoisomerase I specific) and VM-26 (topoisomerase II specific) to assess the role of these enzymes in transcriptional regulation.	Camptothecin	149-161	Topoisomerase 1	Drosophila melanogaster	163-178
12113771-2	2002	Only captafol inhibited the activity of topoisomerase I (10-20% inhibition of activity in the range of 10-100microM).	captafol	5-13	Topoisomerase 1	Drosophila melanogaster	40-55