PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25645334-10	2015	However, TUG1, BC200 and MIR155HG are down regulated when necrosis is induced using a high dose of DOX in both cell lines.	Doxorubicin	99-102	brain cytoplasmic RNA 1	Homo sapiens	15-20
18316401-6	2008	BC200 RNA, the primate-specific BC1 counterpart, targets eIF4A activity in identical fashion, as a result decoupling ATP hydrolysis from RNA duplex unwinding.	Adenosine Triphosphate	117-120	brain cytoplasmic RNA 1	Homo sapiens	0-5
19534148-6	2009	Chemical speciation, X-ray diffraction, and infrared spectroscopy indicated that Pb was precipitated as beta-Pb9(PO4)6 in BC25 and BC200 treatment, and as Pb3(CO3)2(OH)2 in BC350.	Lead	81-83	brain cytoplasmic RNA 1	Homo sapiens	131-136
9131672-6	1997	In sucrose gradients, the BC200 particle has a sedimentation constant of about 11.4 S, significantly more than the corresponding 200 nucleotide long naked RNA (approximately 7.6 S).	Sucrose	3-10	brain cytoplasmic RNA 1	Homo sapiens	26-31
12162957-7	2002	Competition experiments using variants of BC1 and BC200 RNAs demonstrated that the central adenosine-rich region of both RNAs mediates binding to PABP.	Adenosine	91-100	brain cytoplasmic RNA 1	Homo sapiens	50-55
35586620-9	2022	Further, in PAd patients circulating BC200 levels are positively correlated with serum total calcium.	Calcium	93-100	brain cytoplasmic RNA 1	Homo sapiens	37-42
1603265-7	1992	Our results indicate a strong BC200 presence in both the normal brains and NAD affected neocortices, but a 70 per cent reduction in BC200 signal strength in AD afflicted brains.	nadide	75-78	brain cytoplasmic RNA 1	Homo sapiens	30-35
34466147-17	2021	XAV939 attenuated the effect of BCYRN1 overexpression on HTR-8/SVneo cells.	XAV939	0-6	brain cytoplasmic RNA 1	Homo sapiens	32-38
34466147-15	2021	Cells overexpressing BCYRN1 were further treated with the Wnt pathway inhibitor XAV939.	XAV939	80-86	brain cytoplasmic RNA 1	Homo sapiens	21-27
35225646-10	2022	More importantly, miR-30b-3p possessed the binding sites with BCYRN1.	mir-30b-3p	18-28	brain cytoplasmic RNA 1	Homo sapiens	62-68
1081986-6	1976	The frequency of transformation to ampicillin resistance was two- to fivefold higher in strain BC200 (Okinaka and Barnhart, 1974), which was cured of a defective prophage.	Ampicillin	35-45	brain cytoplasmic RNA 1	Homo sapiens	95-100
1081986-7	1976	All three clinical ampicillin-resistant strains were poor recipients, but the presence of the ampicillin resistant genes in strain BC200 did not reduce its competence.	Ampicillin	94-104	brain cytoplasmic RNA 1	Homo sapiens	131-136
31152845-3	2019	Using the tongue carcinoma cell line, TCA8113 as a cell model, we showed that forced expression of ECRG4 down-regulated the expression of the BC200 long non-coding RNA (lncRNA) and matrix metalloproteinases (MMP-9 and MMP-13).	tca8113	38-45	brain cytoplasmic RNA 1	Homo sapiens	142-147
32944001-6	2020	BCYRN1 was knocked down in CRC cells, and cell proliferation changes were evaluated by cell counting kit-8 (CCK-8), 5-ethynyl-2"-deoxyuridine (EdU), and Ki-67 and proliferating cell nuclear antigen (PCNA) expression assays.	5-ethynyl-2'-deoxyuridine	143-146	brain cytoplasmic RNA 1	Homo sapiens	0-6
32944001-9	2020	The dual luciferase reporter gene detects the competitive binding of BCYRN1 to miR-204-3p.	mir-204-3p	79-89	brain cytoplasmic RNA 1	Homo sapiens	69-75
32944001-12	2020	Rescue experiments verified that BCYRN1 affects CRC by regulating the effect of miR-204-3p on KRAS.	mir-204-3p	80-90	brain cytoplasmic RNA 1	Homo sapiens	33-39
32944001-16	2020	Further studies proved that overexpression of miR-204-3p reversed the effects of BCYRN1 on CRC.	mir-204-3p	46-56	brain cytoplasmic RNA 1	Homo sapiens	81-87
32944001-18	2020	A series of rescue experiments showed that BCYRN1 affected the occurrence and development of CRC by regulating the effects of miR-204-3p on KRAS.	mir-204-3p	126-136	brain cytoplasmic RNA 1	Homo sapiens	43-49
32784466-0	2020	Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness.	Temozolomide	56-68	brain cytoplasmic RNA 1	Homo sapiens	10-15
32784466-13	2020	Overexpression and silencing of BC200 RNA both in vitro and in vivo significantly modulated the proliferation, self-renewal, pluripotency, and temozolomide (TMZ) chemo-resistance of GB cells.	Temozolomide	143-155	brain cytoplasmic RNA 1	Homo sapiens	32-37
32784466-13	2020	Overexpression and silencing of BC200 RNA both in vitro and in vivo significantly modulated the proliferation, self-renewal, pluripotency, and temozolomide (TMZ) chemo-resistance of GB cells.	Temozolomide	157-160	brain cytoplasmic RNA 1	Homo sapiens	32-37
32784466-15	2020	miR-218-5p inhibited the expression of BC200.	mir-218-5p	0-10	brain cytoplasmic RNA 1	Homo sapiens	39-44
32784466-16	2020	Conclusions: This study is the first to show that the molecular mechanism of BC200 promotes GB oncogenicity and TMZ resistance through miR-218-5p expression modulation.	Temozolomide	112-115	brain cytoplasmic RNA 1	Homo sapiens	77-82
32104095-0	2020	The lncRNA BCYRN1 Functions as an Oncogene in Human Glioma by Downregulating miR-125a-5p in vitro.	mir-125a-5p	77-88	brain cytoplasmic RNA 1	Homo sapiens	11-17
32104095-9	2020	BCYRN1 was negatively correlated with miR-125a-5p.	mir-125a	38-46	brain cytoplasmic RNA 1	Homo sapiens	0-6
33410401-9	2021	Cross-linking sucrose density gradient centrifugation demonstrated an association of BC200 and its reported binding partners SRP9/14, CSDE1, DHX36, and PABPC1 with both ribosomal subunits and polysomal RNA, an association not previously observed owing to the labile nature of the interactions.	Sucrose	14-21	brain cytoplasmic RNA 1	Homo sapiens	85-90
32016455-5	2020	The effect of BCYRN1 on aerobic glycolysis was examined by measuring NSCLC cell glucose catabolism and lactate synthesis.	Lactic Acid	103-110	brain cytoplasmic RNA 1	Homo sapiens	14-20
32016455-10	2020	In addition, BCYRN1 regulated miR-149 expression levels, and miR-149 inhibitor rescued the effects of si-BCYRN1 on glucose consumption and lactate production.	Glucose	115-122	brain cytoplasmic RNA 1	Homo sapiens	13-19
32016455-10	2020	In addition, BCYRN1 regulated miR-149 expression levels, and miR-149 inhibitor rescued the effects of si-BCYRN1 on glucose consumption and lactate production.	Glucose	115-122	brain cytoplasmic RNA 1	Homo sapiens	105-111
32016455-10	2020	In addition, BCYRN1 regulated miR-149 expression levels, and miR-149 inhibitor rescued the effects of si-BCYRN1 on glucose consumption and lactate production.	Lactic Acid	139-146	brain cytoplasmic RNA 1	Homo sapiens	13-19
32016455-10	2020	In addition, BCYRN1 regulated miR-149 expression levels, and miR-149 inhibitor rescued the effects of si-BCYRN1 on glucose consumption and lactate production.	Lactic Acid	139-146	brain cytoplasmic RNA 1	Homo sapiens	105-111
31250622-4	2019	Here, we report that BC200 RNA sequences are highly heterogeneous in cancer cells by virtue of multiple adenine nucleotide insertions in the internal A-rich region.	Adenine Nucleotides	104-122	brain cytoplasmic RNA 1	Homo sapiens	21-26
31250622-5	2019	The insertion of adenine nucleotides enhances BC200 RNAmediated translation inhibition, possibly by increasing the binding affinity of BC200 RNA for eIF4A (eukaryotic translation initiation factor 4A).	Adenine Nucleotides	17-36	brain cytoplasmic RNA 1	Homo sapiens	46-51
31250622-5	2019	The insertion of adenine nucleotides enhances BC200 RNAmediated translation inhibition, possibly by increasing the binding affinity of BC200 RNA for eIF4A (eukaryotic translation initiation factor 4A).	Adenine Nucleotides	17-36	brain cytoplasmic RNA 1	Homo sapiens	135-140
29979260-4	2018	Cell viability following BC200 knockdown and overexpression was assessed by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyltetrazolium bromide assay, and cell apoptosis was monitored by flow cytometry.	3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyltetrazolium bromide	76-138	brain cytoplasmic RNA 1	Homo sapiens	25-30
30779077-0	2019	LncRNA BC200 regulates the cell proliferation and cisplatin resistance in non-small cell lung cancer via PI3K/AKT pathway.	Cisplatin	50-59	brain cytoplasmic RNA 1	Homo sapiens	7-12
30779077-10	2019	Finally, cell counting kit-8 (CCK-8) assay was carried out to explore the effect of BC200 on cisplatin resistance of LC cells via calculating IC50.	Cisplatin	93-102	brain cytoplasmic RNA 1	Homo sapiens	84-89
30779077-18	2019	BC200 promotes the malignant progression of NSCLC via regulating cisplatin-induced apoptosis of H1299/DDP cells.	Cisplatin	65-74	brain cytoplasmic RNA 1	Homo sapiens	0-5
29552212-9	2018	Subsequently, elevated levels of miR-138 were suppressed by transfection with miR-138 inhibitor in HeLa cells pretreated with BCYRN1 siRNA.	mir-138	33-40	brain cytoplasmic RNA 1	Homo sapiens	126-132
30175286-4	2018	Originally described as a brain-specific, non-coding RNA, BC200 (BCYRN1) is a 200-nucleotide, predominantly cytoplasmic lncRNA that has been linked to neurodegenerative disease and several types of cancer.	200-nucleotide	78-92	brain cytoplasmic RNA 1	Homo sapiens	58-63
30175286-4	2018	Originally described as a brain-specific, non-coding RNA, BC200 (BCYRN1) is a 200-nucleotide, predominantly cytoplasmic lncRNA that has been linked to neurodegenerative disease and several types of cancer.	200-nucleotide	78-92	brain cytoplasmic RNA 1	Homo sapiens	65-71
29552212-9	2018	Subsequently, elevated levels of miR-138 were suppressed by transfection with miR-138 inhibitor in HeLa cells pretreated with BCYRN1 siRNA.	mir-138	78-85	brain cytoplasmic RNA 1	Homo sapiens	126-132
29552212-10	2018	The targeting association between BCYRN1 and miR-138 was supported by luciferase reporter assays.	mir-138	45-52	brain cytoplasmic RNA 1	Homo sapiens	34-40
29552212-11	2018	Additionally, BCYRN1 siRNA partially counteracted the effect of miR-138 inhibitor on promoting cell viability and mobility in HeLa cells.	mir-138	64-71	brain cytoplasmic RNA 1	Homo sapiens	14-20
29552212-13	2018	These results suggest that lncRNA BCYRN1 promotes the proliferation and invasion of cervical cancer via targeting miR-138.	mir-138	114-121	brain cytoplasmic RNA 1	Homo sapiens	34-40
29039538-8	2017	Therefore, the present study suggested that XIST, BCYRN1, RRP1B and TDRG1 may be served as potential diagnostic biomarkers for EGC.	(-)-Epigallocatechin	127-130	brain cytoplasmic RNA 1	Homo sapiens	50-56
28783786-5	2017	Nuclear magnetic resonance spectroscopy data showed that BC200 contained mainly aliphatic C compounds (86% of O-alkyl) belonging to cellulose and hemicellulose, whereas BC400 and BC600 composition was dominated by fused aromatic C structures, containing 81 and 97% aromatic C, respectively.	Cellulose	132-141	brain cytoplasmic RNA 1	Homo sapiens	57-62
28783786-5	2017	Nuclear magnetic resonance spectroscopy data showed that BC200 contained mainly aliphatic C compounds (86% of O-alkyl) belonging to cellulose and hemicellulose, whereas BC400 and BC600 composition was dominated by fused aromatic C structures, containing 81 and 97% aromatic C, respectively.	hemicellulose	146-159	brain cytoplasmic RNA 1	Homo sapiens	57-62
28802992-2	2017	Due to the plentiful polar functional groups on BC200, cationic propranolol exhibited higher levels of sorption than naphthalene on BC200 while naphthalene and propranolol showed similar sorption capacities on BC700.	Propranolol	64-75	brain cytoplasmic RNA 1	Homo sapiens	48-53
28802992-2	2017	Due to the plentiful polar functional groups on BC200, cationic propranolol exhibited higher levels of sorption than naphthalene on BC200 while naphthalene and propranolol showed similar sorption capacities on BC700.	Propranolol	64-75	brain cytoplasmic RNA 1	Homo sapiens	132-137
28802992-2	2017	Due to the plentiful polar functional groups on BC200, cationic propranolol exhibited higher levels of sorption than naphthalene on BC200 while naphthalene and propranolol showed similar sorption capacities on BC700.	naphthalene	117-128	brain cytoplasmic RNA 1	Homo sapiens	132-137
28802992-6	2017	Complexation between polar functional groups on BC200 and heavy metals slightly enhanced the sorption of neutral naphthalene and significantly enhanced that of anionic 4-nitro-1-naphtol, while limited the sorption of cationic propranolol.	naphthalene	113-124	brain cytoplasmic RNA 1	Homo sapiens	48-53
28802992-6	2017	Complexation between polar functional groups on BC200 and heavy metals slightly enhanced the sorption of neutral naphthalene and significantly enhanced that of anionic 4-nitro-1-naphtol, while limited the sorption of cationic propranolol.	4-nitro-1-naphtol	168-185	brain cytoplasmic RNA 1	Homo sapiens	48-53
28802992-6	2017	Complexation between polar functional groups on BC200 and heavy metals slightly enhanced the sorption of neutral naphthalene and significantly enhanced that of anionic 4-nitro-1-naphtol, while limited the sorption of cationic propranolol.	Propranolol	226-237	brain cytoplasmic RNA 1	Homo sapiens	48-53
28277927-9	2017	An actinomycin-chase experiment showed that BC200 RNA knockdown significantly decreased the stability of the S100A11 mRNA without changing its transcription rate, suggesting that the downregulation of S100A11 was mainly caused by destabilization of its mRNA.	Dactinomycin	3-14	brain cytoplasmic RNA 1	Homo sapiens	44-49
28651607-5	2017	Cell viability following BC200 knockdown and overexpression was assessed by MTT assay and induction of apoptosis was monitored by Annexin V/PI staining and flow cytometry.	monooxyethylene trimethylolpropane tristearate	76-79	brain cytoplasmic RNA 1	Homo sapiens	25-30
27277684-6	2016	Mechanistically, BC200 contains a 17-nucleotide sequence complementary to Bcl-x pre-mRNA, which may facilitate its binding to Bcl-x pre-mRNA and recruitment of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a known splicing factor.	17-nucleotide	34-47	brain cytoplasmic RNA 1	Homo sapiens	17-22
26893717-0	2016	Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin.	Carboplatin	106-117	brain cytoplasmic RNA 1	Homo sapiens	18-23
26893717-10	2016	Additionally, it was observed that carboplatin induced BC200 expression in the cell lines, and that the inhibition of BC200 decreased the sensitivity of the cells to the drug.	Carboplatin	35-46	brain cytoplasmic RNA 1	Homo sapiens	55-60
26893717-10	2016	Additionally, it was observed that carboplatin induced BC200 expression in the cell lines, and that the inhibition of BC200 decreased the sensitivity of the cells to the drug.	Carboplatin	35-46	brain cytoplasmic RNA 1	Homo sapiens	118-123
26893717-12	2016	Furthermore, BC200 appears to serve a role in the mediation of carboplatin-induced ovarian cancer cell death.	Carboplatin	63-74	brain cytoplasmic RNA 1	Homo sapiens	13-18