PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 11485571-9 2001 Over expression of AK3, but not AK4, in both Escherichia coli CV2, a temperature-sensitive AK mutant, and a human embryonic kidney-derived cell line, HEK-293, not only produced significant GTP:AMP phosphotransferase (AK3) activity, but also complemented the CV2 cells at 42 degrees C. Subcellular and submitochondrial fractionation analysis demonstrated that both AK3 and AK4 are localized in the mitochondrial matrix. Guanosine Triphosphate 189-192 adenylate kinase 3 Homo sapiens 19-22 15478799-10 2004 In contrast to its human orthologue (AK3), PfGAK contains a zinc finger motif and binds ionic iron. Iron 94-98 adenylate kinase 3 Homo sapiens 37-40 8917436-9 1996 For Glut-3 and AK-3, mutant (c4) cells showed almost complete loss of the inducible response to both hypoxia and desferrioxamine. Deferoxamine 113-128 adenylate kinase 3 Homo sapiens 15-19 11485571-9 2001 Over expression of AK3, but not AK4, in both Escherichia coli CV2, a temperature-sensitive AK mutant, and a human embryonic kidney-derived cell line, HEK-293, not only produced significant GTP:AMP phosphotransferase (AK3) activity, but also complemented the CV2 cells at 42 degrees C. Subcellular and submitochondrial fractionation analysis demonstrated that both AK3 and AK4 are localized in the mitochondrial matrix. Adenosine Monophosphate 193-196 adenylate kinase 3 Homo sapiens 19-22 8439550-2 1993 The derived protein sequence is most closely related to mammalian GTP:AMP phosphotransferase (adenylate kinase isozyme 3; AK3); this novel gene is therefore named ADK3. Guanosine Triphosphate 66-69 adenylate kinase 3 Homo sapiens 122-125 1868097-4 1991 At least five such states are observed, for example, for the well-resolved A14 beta H3 group, and K3, which is six residues sequentially removed from the nearest proline, i.e., P9, shows two sets. Proline 162-169 adenylate kinase 3 Homo sapiens 75-100 1448660-5 1992 Several of these chromosomes carry important genes of adenine metabolism: AK1 and AK3 (adenylate kinase) and MTAP (methylthioadenosine phosphorylase) for chromosome 9; ADK (adenosine kinase) and mitochondrial ATPase for chromosome 10; ADSL (adenylosuccinate lyase) for chromosome 22, NP (nucleoside phosphorylase) for chromosome 14. Adenine 54-61 adenylate kinase 3 Homo sapiens 82-85 32196830-15 2020 CONCLUSION: Our results identify a role for miR-96-5p in promoting breast cancer cell migration through activation of MEK/ERK signaling by targeting AK3. mir-96-5p 44-53 adenylate kinase 3 Homo sapiens 149-152 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. magnesium ion 133-137 adenylate kinase 3 Homo sapiens 29-32 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. Guanosine Triphosphate 138-141 adenylate kinase 3 Homo sapiens 29-32 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. Adenosine Monophosphate 144-147 adenylate kinase 3 Homo sapiens 29-32 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. magnesium ion 150-154 adenylate kinase 3 Homo sapiens 29-32 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. Guanosine Diphosphate 155-158 adenylate kinase 3 Homo sapiens 29-32 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. Adenosine Diphosphate 161-164 adenylate kinase 3 Homo sapiens 29-32 35457131-6 2022 An intracellular ATP evaluation of AK3KO HeLa cells transfected with ATeam plasmid, an ATP sensor, showed decreased whole cell levels. Adenosine Triphosphate 17-20 adenylate kinase 3 Homo sapiens 35-38 35457131-6 2022 An intracellular ATP evaluation of AK3KO HeLa cells transfected with ATeam plasmid, an ATP sensor, showed decreased whole cell levels. Adenosine Triphosphate 87-90 adenylate kinase 3 Homo sapiens 35-38 5940-4 1976 The AK3 isozymes show activity with either GTP + AMP or ITP + AMP but do not show activity with ATP + AMP. gtp + amp 43-52 adenylate kinase 3 Homo sapiens 4-7 5940-4 1976 The AK3 isozymes show activity with either GTP + AMP or ITP + AMP but do not show activity with ATP + AMP. itp + amp 56-65 adenylate kinase 3 Homo sapiens 4-7 32822537-0 2020 Structural basis for GTP versus ATP selectivity in the NMP kinase AK3. Guanosine Triphosphate 21-24 adenylate kinase 3 Homo sapiens 66-69 32822537-0 2020 Structural basis for GTP versus ATP selectivity in the NMP kinase AK3. Adenosine Triphosphate 32-35 adenylate kinase 3 Homo sapiens 66-69 32822537-3 2020 Here, this specific problem is addressed by molecular studies of the human NMP kinase AK3 which uses GTP to phosphorylate AMP. Guanosine Triphosphate 101-104 adenylate kinase 3 Homo sapiens 86-89 32822537-3 2020 Here, this specific problem is addressed by molecular studies of the human NMP kinase AK3 which uses GTP to phosphorylate AMP. Adenosine Monophosphate 122-125 adenylate kinase 3 Homo sapiens 86-89 32822537-4 2020 AK3 plays an important role in the citric acid cycle where it is responsible for GTP/GDP recycling. Citric Acid 35-46 adenylate kinase 3 Homo sapiens 0-3 32822537-4 2020 AK3 plays an important role in the citric acid cycle where it is responsible for GTP/GDP recycling. Guanosine Triphosphate 81-84 adenylate kinase 3 Homo sapiens 0-3 32822537-4 2020 AK3 plays an important role in the citric acid cycle where it is responsible for GTP/GDP recycling. Guanosine Diphosphate 85-88 adenylate kinase 3 Homo sapiens 0-3 32822537-6 2020 We discovered that AK3 functions by recruitment of GTP to the active site, while ATP is rejected and non-productively bound to the AMP binding site. Guanosine Triphosphate 51-54 adenylate kinase 3 Homo sapiens 19-22 32822537-6 2020 We discovered that AK3 functions by recruitment of GTP to the active site, while ATP is rejected and non-productively bound to the AMP binding site. Adenosine Monophosphate 131-134 adenylate kinase 3 Homo sapiens 19-22 29769406-1 2018 AK3 compounds are mitotic arrest agents that induce high levels of gammaH2AX during mitosis and apoptosis following release from arrest. gammah2ax 67-76 adenylate kinase 3 Homo sapiens 0-3 29769406-2 2018 We synthesized a potent AK3 derivative, AK306, that induced arrest and apoptosis of the HCT116 colon cancer cell line with an EC50 of approximately 50 nmol/L. ak306 40-45 adenylate kinase 3 Homo sapiens 24-27 28302504-10 2017 Moreover, the increased AK3 activity could deplete mitochondrial GTP pools and possibly inhibit normal activity of GTP-dependent fusion enzymes, thus altering mitochondrial dynamics. Guanosine Triphosphate 65-68 adenylate kinase 3 Homo sapiens 24-27 28302504-10 2017 Moreover, the increased AK3 activity could deplete mitochondrial GTP pools and possibly inhibit normal activity of GTP-dependent fusion enzymes, thus altering mitochondrial dynamics. Guanosine Triphosphate 115-118 adenylate kinase 3 Homo sapiens 24-27 29448736-1 2018 New three emitting compounds, AK-1, AK-2 and AK-3 including diazocine moiety were synthesized through Suzuki-coupling reaction. 1,2-Diazocine 60-69 adenylate kinase 3 Homo sapiens 45-49 28302504-8 2017 Elevated AMP levels have been reported to reduce mitochondrial ATP production by inhibiting the adenine nucleotide translocase (ANT), allosterically activating AMPK by altering the cellular AMP: ATP ratio, and by depleting mitochondrial GTP pools by being phosphorylated by adenylate kinase 3 (AK3), which uses GTP as a phosphate donor. Adenosine Monophosphate 9-12 adenylate kinase 3 Homo sapiens 274-292 28302504-8 2017 Elevated AMP levels have been reported to reduce mitochondrial ATP production by inhibiting the adenine nucleotide translocase (ANT), allosterically activating AMPK by altering the cellular AMP: ATP ratio, and by depleting mitochondrial GTP pools by being phosphorylated by adenylate kinase 3 (AK3), which uses GTP as a phosphate donor. Adenosine Monophosphate 9-12 adenylate kinase 3 Homo sapiens 294-297 21698293-0 2011 Adenylate kinase 3 sensitizes cells to cigarette smoke condensate vapor induced cisplatin resistance. Cisplatin 80-89 adenylate kinase 3 Homo sapiens 0-18 21698293-7 2011 Re-expression of AK3 in CSC vapor-exposed cells restored cellular sensitivity to cisplatin. Cisplatin 81-90 adenylate kinase 3 Homo sapiens 17-20