PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31912273-0	2020	Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.	phenylalanyl-glycyl-histidyl-statyl-alanyl-phenylalanine methyl ester	0-11	prothymosin alpha pseudogene 9	Homo sapiens	25-42
31912273-0	2020	Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury.	Cisplatin	54-63	prothymosin alpha pseudogene 9	Homo sapiens	25-42
31717548-0	2019	Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide.	Carbon	21-22	prothymosin alpha pseudogene 9	Homo sapiens	65-82
31717548-1	2019	Prothymosin alpha (proTalpha) and its C-terminal decapeptide proTalpha(100-109) were shown to pleiotropically enhance innate and adaptive immune responses.	Carbon	38-39	prothymosin alpha pseudogene 9	Homo sapiens	0-29
30187212-7	2018	These results suggest that the high net negative charge of the glutamic acid-rich region of prothymosin-alpha is not a sufficient criterion for Zn2+ to induce a structural change; rather, Zn2+ binding to prothymosin-alpha is sequence specific, providing important insight into the behavior of intrinsically disordered proteins.	Glutamic Acid	63-76	prothymosin alpha pseudogene 9	Homo sapiens	92-109
30529354-1	2019	pH-induced structural changes of the synthetic homopolypeptides poly-E, poly-K, poly-R, and intrinsically disordered proteins (IDPs) prothymosin alpha (ProTalpha) and linker histone H1, in concentrated PEG solutions simulating macromolecular crowding conditions within the membrane-less organelles, were characterized.	Polyethylene Glycols	202-205	prothymosin alpha pseudogene 9	Homo sapiens	133-150
30187212-0	2018	Zn2+-binding in the glutamate-rich region of the intrinsically disordered protein prothymosin-alpha.	Zinc	0-4	prothymosin alpha pseudogene 9	Homo sapiens	82-99
30187212-7	2018	These results suggest that the high net negative charge of the glutamic acid-rich region of prothymosin-alpha is not a sufficient criterion for Zn2+ to induce a structural change; rather, Zn2+ binding to prothymosin-alpha is sequence specific, providing important insight into the behavior of intrinsically disordered proteins.	Zinc	188-192	prothymosin alpha pseudogene 9	Homo sapiens	204-221
30187212-0	2018	Zn2+-binding in the glutamate-rich region of the intrinsically disordered protein prothymosin-alpha.	Glutamic Acid	20-29	prothymosin alpha pseudogene 9	Homo sapiens	82-99
27751820-0	2016	Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin.	Cisplatin	85-94	prothymosin alpha pseudogene 9	Homo sapiens	22-39
30187212-1	2018	Prothymosin-alpha is a small, multifunctional intrinsically disordered protein associated with cell survival and proliferation which binds multiple Zn2+ ions and undergoes partial folding.	Zinc	148-152	prothymosin alpha pseudogene 9	Homo sapiens	0-17
30187212-2	2018	The interaction between prothymosin-alpha and at least two of its protein targets is significantly enhanced in the presence of Zn2+ ions, suggesting that Zn2+ binding plays a role in the protein"s function.	Zinc	127-131	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-2	2018	The interaction between prothymosin-alpha and at least two of its protein targets is significantly enhanced in the presence of Zn2+ ions, suggesting that Zn2+ binding plays a role in the protein"s function.	Zinc	154-158	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Aspartic Acid	89-92	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Glutamic Acid	97-100	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Cysteine	156-159	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-3	2018	The primary sequence of prothymosin-alpha is highly acidic, with almost 50% comprised of Asp and Glu, and is unusual for a Zn2+-binding protein as it lacks Cys and His residues.	Histidine	164-167	prothymosin alpha pseudogene 9	Homo sapiens	24-41
30187212-4	2018	To gain a better understanding of the nature of the Zn2+-prothymosin-alpha interactions and the protein"s ability to discriminate Zn2+ over other divalent cations (e.g., Ca2+, Co2+, Mg2+) we synthesized a set of three model peptides and characterized the effect of metal binding using electrospray ionization mass spectrometry (ESI MS) and circular dichroism (CD) spectroscopy.	Zinc	52-56	prothymosin alpha pseudogene 9	Homo sapiens	57-74
25451688-0	2015	Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis.	Sorafenib	85-94	prothymosin alpha pseudogene 9	Homo sapiens	20-37
26517516-0	2015	Identification of the beta-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells.	Sorafenib	83-92	prothymosin alpha pseudogene 9	Homo sapiens	39-56
25796124-0	2015	Specific in vitro binding of a new (99m)Tc-radiolabeled derivative of the C-terminal decapeptide of prothymosin alpha on human neutrophils.	Technetium	40-42	prothymosin alpha pseudogene 9	Homo sapiens	100-117
10903508-0	2000	Divalent metal cation binding properties of human prothymosin alpha.	Metals	9-14	prothymosin alpha pseudogene 9	Homo sapiens	50-67
12709435-4	2003	In neuroblastoma cells, 17 beta-estradiol treatment induced a transient increase in the transcription of estrogen-responsive element-containing promoters including those regulating TGF-alpha and prothymosin alpha synthesis.	Estradiol	24-41	prothymosin alpha pseudogene 9	Homo sapiens	195-212
11967287-2	2002	Previous studies demonstrated that EBNA3C interacts with a small, nonhistone, highly acidic, high-mobility group-like nuclear protein prothymosin alpha (ProT(alpha)) and the transcriptional coactivator p300 in complexes from EBV-infected cells.	nonhistone	66-76	prothymosin alpha pseudogene 9	Homo sapiens	134-151
10990488-8	2000	Mild digitonin treatment resulted in nuclei devoid of prothymosin alpha.	Digitonin	5-14	prothymosin alpha pseudogene 9	Homo sapiens	54-71
10990488-10	2000	Therefore, we propose that prothymosin alpha is a highly diffusible bolus of salt and infer that it facilitates movement of charged molecules in highly charged environments within and near the nucleus.	Salts	77-81	prothymosin alpha pseudogene 9	Homo sapiens	27-44
20121050-3	2010	In this study, we investigate how BETT regulates prothymosin alpha (ProT), a nuclear protein previously shown to play essential roles in apoptosis.	5-(2-benzofuryl)-4-phenyl-1,2,4-triazole-3-thiol	34-38	prothymosin alpha pseudogene 9	Homo sapiens	49-66
15325071-6	2004	Moreover nocodazole treatment disrupted prothymosin alpha and alpha-tubulin colocalization at the centrosomes of the interphase cell.	Nocodazole	9-19	prothymosin alpha pseudogene 9	Homo sapiens	40-57
11548126-0	2001	Secondary structure of prothymosin alpha evidenced for conformational transitions induced by changes in temperature and concentration of n-dodecyltrimethylammonium bromide.	dodecyltrimethylammonium	137-171	prothymosin alpha pseudogene 9	Homo sapiens	23-40
11548126-1	2001	Conformational changes of prothymosin alpha (ProTalpha) induced by changes in temperature and concentration of the denaturant n-dodecyltrimethylammonium bromide (C12TAB) were studied by difference spectroscopy.	dodecyltrimethylammonium	126-160	prothymosin alpha pseudogene 9	Homo sapiens	26-43
11548126-1	2001	Conformational changes of prothymosin alpha (ProTalpha) induced by changes in temperature and concentration of the denaturant n-dodecyltrimethylammonium bromide (C12TAB) were studied by difference spectroscopy.	c12tab	162-168	prothymosin alpha pseudogene 9	Homo sapiens	26-43
10903508-2	2000	By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.	Zinc	131-135	prothymosin alpha pseudogene 9	Homo sapiens	9-26
10903508-2	2000	By using prothymosin alpha retardation on a weak cation chelating resin charged with various divalent cations, specific binding of Zn2+ ions by prothymosin alpha was observed.	Zinc	131-135	prothymosin alpha pseudogene 9	Homo sapiens	144-161
10903508-3	2000	This finding was further confirmed by the equilibrium dialysis analysis which demonstrated that, within the micromolar range of Zn2+ concentrations, prothymosin alpha could bind up to three zinc ions in the presence of 100 mM NaCl and up to 13 zinc ions in the absence of NaCl.	Zinc	128-132	prothymosin alpha pseudogene 9	Homo sapiens	149-166
10903508-3	2000	This finding was further confirmed by the equilibrium dialysis analysis which demonstrated that, within the micromolar range of Zn2+ concentrations, prothymosin alpha could bind up to three zinc ions in the presence of 100 mM NaCl and up to 13 zinc ions in the absence of NaCl.	Sodium Chloride	226-230	prothymosin alpha pseudogene 9	Homo sapiens	149-166
10903508-3	2000	This finding was further confirmed by the equilibrium dialysis analysis which demonstrated that, within the micromolar range of Zn2+ concentrations, prothymosin alpha could bind up to three zinc ions in the presence of 100 mM NaCl and up to 13 zinc ions in the absence of NaCl.	Sodium Chloride	272-276	prothymosin alpha pseudogene 9	Homo sapiens	149-166
10903508-4	2000	Equilibrium dialysis analysis also revealed that prothymosin alpha could bind Ca2+, although the parameters of Ca2+ binding by prothymosin alpha were less pronounced than those of Zn2+ binding in terms of the number of metal ions bound, the KD values, and the resistance of the bound metal ions to 100 mM NaCl.	Metals	219-224	prothymosin alpha pseudogene 9	Homo sapiens	49-66
10903508-4	2000	Equilibrium dialysis analysis also revealed that prothymosin alpha could bind Ca2+, although the parameters of Ca2+ binding by prothymosin alpha were less pronounced than those of Zn2+ binding in terms of the number of metal ions bound, the KD values, and the resistance of the bound metal ions to 100 mM NaCl.	Metals	284-289	prothymosin alpha pseudogene 9	Homo sapiens	49-66
10903508-4	2000	Equilibrium dialysis analysis also revealed that prothymosin alpha could bind Ca2+, although the parameters of Ca2+ binding by prothymosin alpha were less pronounced than those of Zn2+ binding in terms of the number of metal ions bound, the KD values, and the resistance of the bound metal ions to 100 mM NaCl.	Sodium Chloride	305-309	prothymosin alpha pseudogene 9	Homo sapiens	49-66
10903508-5	2000	The effects of Zn2+ and Ca2+ on the interaction of prothymosin alpha with its putative partners, Rev of HIV type 1 and histone H1, were examined.	Zinc	15-19	prothymosin alpha pseudogene 9	Homo sapiens	51-68
10903508-6	2000	We demonstrated that Rev binds prothymosin alpha, and that prothymosin alpha binding to Rev but not to histone H1 was significantly enhanced in the presence of zinc and calcium ions.	REV	21-24	prothymosin alpha pseudogene 9	Homo sapiens	31-48
10903508-6	2000	We demonstrated that Rev binds prothymosin alpha, and that prothymosin alpha binding to Rev but not to histone H1 was significantly enhanced in the presence of zinc and calcium ions.	REV	88-91	prothymosin alpha pseudogene 9	Homo sapiens	59-76
10903508-6	2000	We demonstrated that Rev binds prothymosin alpha, and that prothymosin alpha binding to Rev but not to histone H1 was significantly enhanced in the presence of zinc and calcium ions.	Calcium	169-176	prothymosin alpha pseudogene 9	Homo sapiens	59-76
10903508-7	2000	Our data suggest that the modes of prothymosin alpha interaction with Rev and histone H1 are distinct and that the observed zinc and calcium-binding properties of prothymosin alpha might be functionally relevant.	Calcium	133-140	prothymosin alpha pseudogene 9	Homo sapiens	163-180
10555983-2	1999	The structural properties and conformational stability of recombinant human prothymosin alpha were characterized at neutral and acidic pH by gel filtration, SAXS, circular dichroism, ANS fluorescence, (1)H NMR, and resistance to urea-induced unfolding.	Urea	229-233	prothymosin alpha pseudogene 9	Homo sapiens	76-93
10631119-0	2000	Zn(2+)-mediated structure formation and compaction of the "natively unfolded" human prothymosin alpha.	Zinc	0-6	prothymosin alpha pseudogene 9	Homo sapiens	84-101
10623890-7	2000	(3) Carbobenzoxy-DEVD-fluoromethylketone, a cell-permeable caspase 3 inhibitor, blocked cleavage and degradation of prothymosin alpha.	(3) carbobenzoxy-devd-fluoromethylketone	0-40	prothymosin alpha pseudogene 9	Homo sapiens	116-133
10623890-11	2000	Two immediate consequences of the cleavage were observed: truncated prothymosin alpha was no longer confined to the nucleus and it was deficient in phosphate.	Phosphates	148-157	prothymosin alpha pseudogene 9	Homo sapiens	68-85
7588773-5	1995	The binding activity of prothymosin alpha to Rev or Rex was completely abolished when the epsilon-amino groups of its lysine residues were chemically modified by N-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate.	Lysine	118-124	prothymosin alpha pseudogene 9	Homo sapiens	24-41
8706683-2	1996	For example, c-myc causes immediate transcriptional activation of prothymosin alpha, and prothymosin alpha antisense oligonucleotides inhibit myeloma cell division.	Oligonucleotides	117-133	prothymosin alpha pseudogene 9	Homo sapiens	89-106
10048579-0	1999	Metabolic regulation of protein-bound glutamyl phosphates: insights into the function of prothymosin alpha.	glutamyl phosphates	38-57	prothymosin alpha pseudogene 9	Homo sapiens	89-106
10048579-4	1999	To understand the function of prothymosin alpha in greater detail, the turnover of its phosphates was examined in metabolically manipulated cells.	Phosphates	87-97	prothymosin alpha pseudogene 9	Homo sapiens	30-47
10048579-6	1999	The values obtained--72-75 min in cells with normal levels of the protein, but 118 min in cells with surplus prothymosin alpha--led us to conclude that underutilized phosphates persist whereas functioning phosphates disperse.	Phosphates	166-176	prothymosin alpha pseudogene 9	Homo sapiens	109-126
10048579-9	1999	In these experiments, reduced utilization of prothymosin alpha"s glutamyl phosphates, signaled by an increase in their half-lives, accompanied the attenuation or abolition of transcription.	glutamyl phosphates	65-84	prothymosin alpha pseudogene 9	Homo sapiens	45-62
10200541-0	1999	Prothymosin alpha antisense oligonucleotides induce apoptosis in HL-60 cells.	Oligonucleotides	28-44	prothymosin alpha pseudogene 9	Homo sapiens	0-17
9334214-0	1997	Prothymosin alpha in vivo contains phosphorylated glutamic acid residues.	Glutamic Acid	50-63	prothymosin alpha pseudogene 9	Homo sapiens	0-17
9334214-1	1997	Human and monkey prothymosin alpha contain activated carbonyl groups on glutamic acid residues.	Glutamic Acid	72-85	prothymosin alpha pseudogene 9	Homo sapiens	17-34
9334214-4	1997	2) Immediately upon cell lysis, the pH stability curves of metabolically labeled native [32P]prothymosin alpha or a [32P]histidine-tagged variant resembled the pH stability curve of acetyl phosphate.	Phosphorus-32	89-92	prothymosin alpha pseudogene 9	Homo sapiens	93-110
9334214-4	1997	2) Immediately upon cell lysis, the pH stability curves of metabolically labeled native [32P]prothymosin alpha or a [32P]histidine-tagged variant resembled the pH stability curve of acetyl phosphate.	acetyl phosphate	182-198	prothymosin alpha pseudogene 9	Homo sapiens	93-110
9334214-10	1997	Our data demonstrate that prothymosin alpha is energy-rich by virtue of stoichiometric amounts of glutamyl phosphate.	glutamyl phosphate	98-116	prothymosin alpha pseudogene 9	Homo sapiens	26-43
9334215-2	1997	Our laboratory has recently shown that primate prothymosin alpha contains stoichiometric amounts of phosphate on the glutamyl groups of the protein and that in vitro the phosphate undergoes rapid hydrolysis or transfer to a nearby serine residue.	Phosphates	100-109	prothymosin alpha pseudogene 9	Homo sapiens	47-64
9334215-2	1997	Our laboratory has recently shown that primate prothymosin alpha contains stoichiometric amounts of phosphate on the glutamyl groups of the protein and that in vitro the phosphate undergoes rapid hydrolysis or transfer to a nearby serine residue.	Phosphates	170-179	prothymosin alpha pseudogene 9	Homo sapiens	47-64
9334215-2	1997	Our laboratory has recently shown that primate prothymosin alpha contains stoichiometric amounts of phosphate on the glutamyl groups of the protein and that in vitro the phosphate undergoes rapid hydrolysis or transfer to a nearby serine residue.	Serine	231-237	prothymosin alpha pseudogene 9	Homo sapiens	47-64
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Phosphates	58-68	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Phosphorus-32	133-136	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Phosphates	137-151	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Digitonin	220-229	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Adenosine Triphosphate	253-256	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Adenosine Triphosphate	336-339	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Phosphorus-32	376-379	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Adenosine Triphosphate	336-339	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-4	1997	The assay was used to determine the half-life of the acyl phosphates on prothymosin alpha in vivo by pulse-labeling HeLa cells with [32P]orthophosphate and chasing using three different techniques: permeabilization with digitonin to allow extracellular ATP to equilibrate with the intracellular pool; electroporation in the presence of ATP to reduce the specific activity of [32P]ATP by expansion of the pool; and incubation with inorganic phosphate.	Phosphates	430-449	prothymosin alpha pseudogene 9	Homo sapiens	72-89
9334215-6	1997	The ability of cells to phosphorylate old prothymosin alpha molecules was established by demonstrating equivalent labeling of the protein with [32P]orthophosphate in the presence and absence of cycloheximide.	Phosphate-32P	143-162	prothymosin alpha pseudogene 9	Homo sapiens	42-59
9334215-6	1997	The ability of cells to phosphorylate old prothymosin alpha molecules was established by demonstrating equivalent labeling of the protein with [32P]orthophosphate in the presence and absence of cycloheximide.	Cycloheximide	194-207	prothymosin alpha pseudogene 9	Homo sapiens	42-59
9334215-8	1997	Our data suggest that the "activity" of prothymosin alpha involves the turnover of its acyl phosphates and that it participates in a function common to all nucleated mammalian cells regardless of whether they are quiescent or undergoing rapid proliferation.	Phosphates	92-102	prothymosin alpha pseudogene 9	Homo sapiens	40-57
8955350-0	1996	Lysine-87 is a functionally important residue in human prothymosin alpha.	Lysine	0-6	prothymosin alpha pseudogene 9	Homo sapiens	55-72
8955350-3	1996	We propose that prothymosin alpha may possess a bipartite rather than monopartite nuclear localization signal, which includes Lys-87, and that the above mutation destroys one part of the nuclear localization signal, thus preventing efficient nuclear uptake of prothymosin alpha.	Lysine	126-129	prothymosin alpha pseudogene 9	Homo sapiens	16-33
7588773-5	1995	The binding activity of prothymosin alpha to Rev or Rex was completely abolished when the epsilon-amino groups of its lysine residues were chemically modified by N-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate.	n-succinimidyl-3-(4-hydroxy-3,5-diodo- phenyl)propionate	162-218	prothymosin alpha pseudogene 9	Homo sapiens	24-41
7649163-2	1995	The highest yield of the human prothymosin alpha, up to 30% of the total bacterial protein, was achieved with constructions containing 6-10 nucleotides between the Shine-Dalgarno sequence and initiation ATG codon.	6-10 nucleotides	135-151	prothymosin alpha pseudogene 9	Homo sapiens	31-48
7639508-0	1995	Superoxide anion generation by human peripheral blood mononuclear cells in response to prothymosin alpha.	Superoxides	0-16	prothymosin alpha pseudogene 9	Homo sapiens	87-104
7639508-1	1995	The ability of human peripheral blood mononuclear cells to respond to highly purified prothymosin alpha by generating superoxide anion was investigated.	Superoxides	118-134	prothymosin alpha pseudogene 9	Homo sapiens	86-103
7639508-6	1995	Selective stimulation of these fractions with prothymosin alpha revealed that different cell populations were responsible for the generation of superoxide at higher and lower concentrations of stimulant, respectively.	Superoxides	144-154	prothymosin alpha pseudogene 9	Homo sapiens	46-63
7639508-10	1995	Finally, simultaneous addition of prothymosin alpha and PMA resulted in a approximately 40% decrease of the O2- generation induced by PMA alone.	Superoxides	108-110	prothymosin alpha pseudogene 9	Homo sapiens	34-51
8444845-6	1993	Structural analysis showed that prothymosin alpha was phosphorylated at Thr residues located among its first 14 amino acids, whereas its in vitro phosphorylation by casein kinase-2 affects both Ser and Thr residues in this fragment, apparently in similar proportions.	Threonine	72-75	prothymosin alpha pseudogene 9	Homo sapiens	32-49
8137916-1	1994	125I-Labeled prothymosin alpha (ProT alpha) was used to study the presence and characteristics of receptors for ProT alpha on human peripheral blood mononuclear cells (PBMC).	Iodine-125	0-4	prothymosin alpha pseudogene 9	Homo sapiens	13-30
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Dimethyl Sulfoxide	192-209	prothymosin alpha pseudogene 9	Homo sapiens	23-40
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Dimethyl Sulfoxide	211-215	prothymosin alpha pseudogene 9	Homo sapiens	23-40
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Tetradecanoylphorbol Acetate	261-289	prothymosin alpha pseudogene 9	Homo sapiens	23-40
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	Tetradecanoylphorbol Acetate	291-294	prothymosin alpha pseudogene 9	Homo sapiens	23-40
8353279-4	1993	Steady-state levels of prothymosin alpha mRNA, which are high in exponentially growing HL-60, decrease within hours after induction of HL-60 to differentiate along the neutrophil pathway with dimethylsulfoxide (DMSO) or along the macrophage lineage with either tetradecanoylphorbol acetate (TPA) or bryostatin 1.	bryostatin 1	299-311	prothymosin alpha pseudogene 9	Homo sapiens	23-40
8485135-2	1993	When human myeloma cells were metabolically labeled with [32P]orthophosphoric acid, they synthesized [32P]prothymosin alpha.	[32p]orthophosphoric acid	57-82	prothymosin alpha pseudogene 9	Homo sapiens	106-123
8485135-2	1993	When human myeloma cells were metabolically labeled with [32P]orthophosphoric acid, they synthesized [32P]prothymosin alpha.	Phosphorus-32	58-62	prothymosin alpha pseudogene 9	Homo sapiens	106-123
8485135-8	1993	Thin-layer electrophoresis of partially hydrolyzed [32P]prothymosin alpha indicated that serine residues were phosphorylated.	Phosphorus-32	52-55	prothymosin alpha pseudogene 9	Homo sapiens	56-73
8485135-8	1993	Thin-layer electrophoresis of partially hydrolyzed [32P]prothymosin alpha indicated that serine residues were phosphorylated.	Serine	89-95	prothymosin alpha pseudogene 9	Homo sapiens	56-73
8485135-13	1993	The results prove that prothymosin alpha contains N-terminal acetylserine phosphate.	acetylserine phosphate	61-83	prothymosin alpha pseudogene 9	Homo sapiens	23-40
7510758-1	1994	A radioimmunoassay specific for the C-terminus of human prothymosin alpha was developed using the synthetic peptide [Cys-Aca degrees]-human prothymosin alpha (90-109)-OH coupled to KLH as antigen and the analogue [Tyr-Aca degrees]-human prothymosin alpha (90-109)-OH labelled with 125I as tracer.	Cysteine	117-120	prothymosin alpha pseudogene 9	Homo sapiens	56-73
7510758-1	1994	A radioimmunoassay specific for the C-terminus of human prothymosin alpha was developed using the synthetic peptide [Cys-Aca degrees]-human prothymosin alpha (90-109)-OH coupled to KLH as antigen and the analogue [Tyr-Aca degrees]-human prothymosin alpha (90-109)-OH labelled with 125I as tracer.	Cysteine	117-120	prothymosin alpha pseudogene 9	Homo sapiens	140-157
7510758-1	1994	A radioimmunoassay specific for the C-terminus of human prothymosin alpha was developed using the synthetic peptide [Cys-Aca degrees]-human prothymosin alpha (90-109)-OH coupled to KLH as antigen and the analogue [Tyr-Aca degrees]-human prothymosin alpha (90-109)-OH labelled with 125I as tracer.	Cysteine	117-120	prothymosin alpha pseudogene 9	Homo sapiens	140-157
7510758-1	1994	A radioimmunoassay specific for the C-terminus of human prothymosin alpha was developed using the synthetic peptide [Cys-Aca degrees]-human prothymosin alpha (90-109)-OH coupled to KLH as antigen and the analogue [Tyr-Aca degrees]-human prothymosin alpha (90-109)-OH labelled with 125I as tracer.	Tyrosine	214-217	prothymosin alpha pseudogene 9	Homo sapiens	56-73
8444845-6	1993	Structural analysis showed that prothymosin alpha was phosphorylated at Thr residues located among its first 14 amino acids, whereas its in vitro phosphorylation by casein kinase-2 affects both Ser and Thr residues in this fragment, apparently in similar proportions.	Serine	194-197	prothymosin alpha pseudogene 9	Homo sapiens	32-49
8444845-9	1993	In thymocytes and subconfluent HeLa cells, the [32P]prothymosin alpha concentrations of the cytosolic and nuclear fractions were similar; in splenic lymphocytes, [32P]prothymosin alpha was found mostly in cytosol.	Phosphorus-32	48-51	prothymosin alpha pseudogene 9	Homo sapiens	52-69
8444845-9	1993	In thymocytes and subconfluent HeLa cells, the [32P]prothymosin alpha concentrations of the cytosolic and nuclear fractions were similar; in splenic lymphocytes, [32P]prothymosin alpha was found mostly in cytosol.	Phosphorus-32	163-166	prothymosin alpha pseudogene 9	Homo sapiens	167-184
2479575-4	1989	Tryptic peptide maps of 125I-labelled RNA-linked proteins of diverse origin demonstrated their marked similarity, thus indicating high evolutionary conservation of prothymosin alpha from yeast to man.	Peptides	8-15	prothymosin alpha pseudogene 9	Homo sapiens	164-181
2136239-1	1990	Human prothymosin alpha, virtually alone among proteins, is recovered from the aqueous phase of phenol-extracted cell lysates prepared from human myeloma cells or COS cells that were transfected with the human prothymosin alpha gene.	Phenol	96-102	prothymosin alpha pseudogene 9	Homo sapiens	6-23
1290467-0	1992	On the anomalous behaviour on gel-filtration and SDS-electrophoresis of prothymosin-alpha.	Sodium Dodecyl Sulfate	49-52	prothymosin alpha pseudogene 9	Homo sapiens	72-89
1290467-3	1992	These results suggest that a dimeric form of prothymosin alpha is stable to dissociation by SDS and reduction by beta-mercapto ethanol.	Sodium Dodecyl Sulfate	92-95	prothymosin alpha pseudogene 9	Homo sapiens	45-62
1290467-3	1992	These results suggest that a dimeric form of prothymosin alpha is stable to dissociation by SDS and reduction by beta-mercapto ethanol.	Mercaptoethanol	113-134	prothymosin alpha pseudogene 9	Homo sapiens	45-62
1986372-1	1991	The function of prothymosin alpha has been investigated by using four different antisense oligodeoxyribonucleotides directed at selected regions of its mRNA.	Oligodeoxyribonucleotides	90-115	prothymosin alpha pseudogene 9	Homo sapiens	16-33
2432409-9	1986	The antiserum bound to prothymosin alpha and thymosin alpha 11, which lack the alpha-carboxylate group of Asn-28, with 0.9 and 0.2%, respectively, of the efficiency of thymosin alpha 1.	alpha-carboxylate	79-96	prothymosin alpha pseudogene 9	Homo sapiens	23-62
2785990-1	1989	We isolated the cDNA for human prothymosin alpha (ProT alpha) from a human peripheral T-cell library using two synthetic oligonucleotides as probes.	Oligonucleotides	121-137	prothymosin alpha pseudogene 9	Homo sapiens	31-48
2708378-8	1989	One of the genes, apparently by means of alternate splicing, gives rise to two prothymosin alpha mRNAs, one of which has an additional internal glutamic acid codon with respect to the other.	Glutamic Acid	144-157	prothymosin alpha pseudogene 9	Homo sapiens	79-96
3466166-4	1986	The presence of an initiator codon immediately preceding the codon for the NH2-terminal serine residue and of a terminator codon immediately following the codon for Asp-109, the COOH-terminal residue, suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide.	Serine	88-94	prothymosin alpha pseudogene 9	Homo sapiens	215-232
3466166-4	1986	The presence of an initiator codon immediately preceding the codon for the NH2-terminal serine residue and of a terminator codon immediately following the codon for Asp-109, the COOH-terminal residue, suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide.	Aspartic Acid	165-168	prothymosin alpha pseudogene 9	Homo sapiens	215-232
3466166-4	1986	The presence of an initiator codon immediately preceding the codon for the NH2-terminal serine residue and of a terminator codon immediately following the codon for Asp-109, the COOH-terminal residue, suggests that prothymosin alpha is synthesized without formation of a larger precursor polypeptide.	Carbonic Acid	178-182	prothymosin alpha pseudogene 9	Homo sapiens	215-232
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Alanine	156-163	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Proline	168-175	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Alanine	177-184	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Valine	189-195	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Aspartic Acid	201-214	prothymosin alpha pseudogene 9	Homo sapiens	6-23
3532956-9	1986	Human prothymosin alpha also differs from rat prothymosin alpha at positions corresponding to residues 87, 92, and 102 of the latter, with substitutions of alanine for proline, alanine for valine, and aspartic acid for glutamic acid, respectively.	Glutamic Acid	219-232	prothymosin alpha pseudogene 9	Homo sapiens	6-23
2432409-9	1986	The antiserum bound to prothymosin alpha and thymosin alpha 11, which lack the alpha-carboxylate group of Asn-28, with 0.9 and 0.2%, respectively, of the efficiency of thymosin alpha 1.	Asparagine	106-109	prothymosin alpha pseudogene 9	Homo sapiens	23-62