PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
8026494-7	1994	One of the sequences protected by the binding factors is a cAMP-responsive-element (CRE)-like sequence, which is known to be recognized by CRE-binding protein (CREB) or its related proteins, and another is a sequence designated Ad4 which is bound by a tissue-specific factor, Ad4-binding protein (Ad4BP).	Cyclic AMP	59-63	presenilin 2	Homo sapiens	228-231
34329977-4	2022	The temperature at 5 wt% weight loss and the maximum weight loss rate of PS/SiO2@3COFs@ Fe2O3 (PS 4) under air are 15 and 14  C higher than that of neat one, respectively.	Iron(III) oxide	88-93	presenilin 2	Homo sapiens	73-86
1336011-2	1992	Although the Ad1 site (TGACGTGA) was similar to a palindromic CRE (TGACGTCA), two other upstream sequences, Ad3 and Ad4, were identified as the cAMP response sequences of the gene.	Cyclic AMP	144-148	presenilin 2	Homo sapiens	116-119
1336011-7	1992	These results indicated that both the Ad1 site and the upstream elements, Ad3 and Ad4, were necessary for the full response to cAMP of the CYP11B gene.	Cyclic AMP	127-131	presenilin 2	Homo sapiens	82-85
34329977-5	2022	The glass-transition temperature of PS/SiO2@3COFs (PS 2) is 1.5  C lower than that of PS, which can conclude that SiO2@3COFs contributes to impact strength of PS 0.	Silicon Dioxide	114-118	presenilin 2	Homo sapiens	36-49
34329977-5	2022	The glass-transition temperature of PS/SiO2@3COFs (PS 2) is 1.5  C lower than that of PS, which can conclude that SiO2@3COFs contributes to impact strength of PS 0.	Silicon Dioxide	114-118	presenilin 2	Homo sapiens	51-55
34481041-0	2021	Emerging therapeutic opportunities of novel thiol-amides, NAC-amide (AD4/NACA) and thioredoxin mimetics (TXM-Peptides) for neurodegenerative-related disorders.	N-Acetylcysteinamide	58-67	presenilin 2	Homo sapiens	69-72
277090-5	1978	Ad 4) Most drug reactions are acute, but an insiduous course, developping to cirrhosis, is increasingly recognized (e.g. oxyphenacetin).	N-(4-ethoxyphenyl)-2-hydroxyacetamide	121-134	presenilin 2	Homo sapiens	0-4
34366829-0	2021	A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer"s Disease in a Chinese Han Family: A Case Report.	phe369ser	45-54	presenilin 2	Homo sapiens	28-33
34366829-9	2021	Our results suggest that this novel PSEN2 Phe369Ser mutation may alter PSEN2 protein function and associate with EOAD.	phe369ser	42-51	presenilin 2	Homo sapiens	36-41
34366829-9	2021	Our results suggest that this novel PSEN2 Phe369Ser mutation may alter PSEN2 protein function and associate with EOAD.	phe369ser	42-51	presenilin 2	Homo sapiens	71-76
35395673-2	2022	DNA sequences of four antigenic domains (AD1, AD2, AD4/5 and AD5) of gB were amplified from six reference and 12 clinical CMV strains, and the most divergent genotypes were determined by phylogenetic analysis.	gb	69-71	presenilin 2	Homo sapiens	51-56
35395008-0	2022	Discovery of novel benzophenone integrated derivatives as anti-Alzheimer"s agents targeting presenilin-1 and presenilin-2 inhibition: A computational approach.	benzophenone	19-31	presenilin 2	Homo sapiens	109-121
32397113-4	2020	Genomic abnormalities associating with lenalidomide resistance in non-del(5q) MDS patients included mutations in SF3B1, TET2, WNT3A amplification, MCL1 amplification, and/or PSEN2 amplification.	Lenalidomide	39-51	presenilin 2	Homo sapiens	174-179
33551720-4	2020	PS2 was more specifically reported to regulate calcium shuttling between these two organelles by controlling the formation of functional MAMs.	Calcium	47-54	presenilin 2	Homo sapiens	0-3
33413468-10	2021	In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production.	radical oxygen species	138-160	presenilin 2	Homo sapiens	28-33
33413468-10	2021	In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production.	ros	162-165	presenilin 2	Homo sapiens	28-33
31405326-1	2020	Presenilins 1 and 2 (PS1 or PS2) are main genetic risk factors of familial Alzheimer"s disease (AD) that produce the beta-amyloid (Abeta) peptides and also have important stand-alone functions related to, e.g. calcium signaling.	Calcium	210-217	presenilin 2	Homo sapiens	28-31
32420742-3	2020	We investigated the interaction of calcium with both PS1 and PS2 using all-atom molecular dynamics (MD) simulations in realistic membrane models, with the specific aim to identify any Ca2+ sites.	Calcium	35-42	presenilin 2	Homo sapiens	61-64
33855622-0	2021	A novel PSEN2 p.Ser175Phe variant in a family with Alzheimer"s disease.	ser175phe	16-25	presenilin 2	Homo sapiens	8-13
33855622-4	2021	In this study, we describe a novel heterozygous PSEN2 (c.524C>T, p.Ser175Phe) alteration identified in a 58-year-old Turkish patient from a family with multiple dementia cases.	ser175phe	67-76	presenilin 2	Homo sapiens	48-53
32420742-7	2020	Calcium consistently dampens HL2 motions in all comparisons (PS1, protonated PS1, PS2, protonated PS2).	Calcium	0-7	presenilin 2	Homo sapiens	82-85
32420742-7	2020	Calcium consistently dampens HL2 motions in all comparisons (PS1, protonated PS1, PS2, protonated PS2).	Calcium	0-7	presenilin 2	Homo sapiens	98-101
31792452-3	2019	We present 3.3 A and 3.5 A cryo-EM structures of E51, a tyrosine-sulfated coreceptor-mimicking antibody, complexed with a CD4-bound open HIV-1 native-like Env trimer.	Tyrosine	56-64	presenilin 2	Homo sapiens	49-52
32106535-7	2020	Moreover, when applying this method to iPSCs from Alzheimer"s disease (AD) patients with presenilin-1 (PS1) or presenilin-2 (PS2) mutations, cellular phenotypes such as increased amount of extracellular secretion of amyloid beta42, abnormal oxygen consumption, and increased reactive oxygen species in the cells were observed in a shorter culture period than those previously reported.	Oxygen	241-247	presenilin 2	Homo sapiens	125-128
32106535-7	2020	Moreover, when applying this method to iPSCs from Alzheimer"s disease (AD) patients with presenilin-1 (PS1) or presenilin-2 (PS2) mutations, cellular phenotypes such as increased amount of extracellular secretion of amyloid beta42, abnormal oxygen consumption, and increased reactive oxygen species in the cells were observed in a shorter culture period than those previously reported.	Reactive Oxygen Species	275-298	presenilin 2	Homo sapiens	125-128
31991578-0	2020	Intracellular Calcium Dysregulation by the Alzheimer"s Disease-Linked Protein Presenilin 2.	Calcium	14-21	presenilin 2	Homo sapiens	78-90
31991578-6	2020	Interestingly, Abeta peptides, mutated presenilin-1 (PS1), and presenilin-2 (PS2) variously lead to modifications in Ca2+ homeostasis.	Calcium	117-121	presenilin 2	Homo sapiens	63-75
31991578-6	2020	Interestingly, Abeta peptides, mutated presenilin-1 (PS1), and presenilin-2 (PS2) variously lead to modifications in Ca2+ homeostasis.	Calcium	117-121	presenilin 2	Homo sapiens	77-80
31991578-7	2020	In this contribution, we focus on PS2, summarizing how AD-linked PS2 mutants alter multiple Ca2+ pathways and the functional consequences of this Ca2+ dysregulation in AD pathogenesis.	Calcium	92-96	presenilin 2	Homo sapiens	34-37
31991578-7	2020	In this contribution, we focus on PS2, summarizing how AD-linked PS2 mutants alter multiple Ca2+ pathways and the functional consequences of this Ca2+ dysregulation in AD pathogenesis.	Calcium	92-96	presenilin 2	Homo sapiens	65-68
31991578-7	2020	In this contribution, we focus on PS2, summarizing how AD-linked PS2 mutants alter multiple Ca2+ pathways and the functional consequences of this Ca2+ dysregulation in AD pathogenesis.	Calcium	146-150	presenilin 2	Homo sapiens	34-37
31991578-7	2020	In this contribution, we focus on PS2, summarizing how AD-linked PS2 mutants alter multiple Ca2+ pathways and the functional consequences of this Ca2+ dysregulation in AD pathogenesis.	Calcium	146-150	presenilin 2	Homo sapiens	65-68
30968232-5	2019	Vildagliptine decreased PSEN1 and PSEN2 mRNA levels which enroll Abeta production.	vildagliptine	0-13	presenilin 2	Homo sapiens	34-39
31606858-0	2021	Familial Alzheimer"s disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability.	Calcium	57-61	presenilin 2	Homo sapiens	29-41
31606858-2	2021	Few cases are familial (FAD), due to autosomal dominant mutations in presenilin-1 (PS1), presenilin-2 (PS2) or amyloid precursor protein (APP).	Flavin-Adenine Dinucleotide	24-27	presenilin 2	Homo sapiens	89-101
31606858-2	2021	Few cases are familial (FAD), due to autosomal dominant mutations in presenilin-1 (PS1), presenilin-2 (PS2) or amyloid precursor protein (APP).	Flavin-Adenine Dinucleotide	24-27	presenilin 2	Homo sapiens	103-106
31606858-6	2021	Interestingly, FAD-linked PS1 and PS2 mutants alter multiple key cellular pathways, including Ca2+ signaling.	Calcium	94-98	presenilin 2	Homo sapiens	34-37
31606858-7	2021	By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.	Calcium	40-44	presenilin 2	Homo sapiens	124-127
31606858-7	2021	By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.	Flavin-Adenine Dinucleotide	113-116	presenilin 2	Homo sapiens	124-127
31606858-7	2021	By generating novel tools for measuring Ca2+ in living cells, and combining different approaches, we showed that FAD-linked PS2 mutants significantly alter cell Ca2+ signaling and brain network activity, as summarized below.	Calcium	161-165	presenilin 2	Homo sapiens	124-127
30969148-7	2019	Results: BAK 0.1% was virucidal for Ad3, Ad5, Ad7a, Ad19/64, and Ad37, while it reduced titers >1 Log10, but <3 Log10 for Ad4 and Ad8.	Benzalkonium Compounds	9-12	presenilin 2	Homo sapiens	128-131
31391004-9	2019	Interestingly, Trp165Cys mutation is located in trans membrane (TM)-III region, which is conserved between PSEN1/PSEN2.	trp165cys	15-24	presenilin 2	Homo sapiens	113-118
30968232-10	2019	These results indicate that vildagliptine exerts a protective effect against Abeta by decreasing apoptosis related proteins, lowering GSK3beta and Tau phosphorylation levels in addition to expression of PSEN1 and PSEN2 mRNA downregulation effect.	vildagliptine	28-41	presenilin 2	Homo sapiens	213-218
29945658-8	2018	Unexpectedly, we found a CRISPR/Cas9-correctable effect of PSEN2 N141I on calcium flux, which could be prevented by chronic exposure of BFCNs to insulin.	Calcium	74-81	presenilin 2	Homo sapiens	59-64
27285176-10	2016	TXM-CB13 similar to TXM-CB3 and AD4 reversed oxidative stress-induced phosphorylation of mitogen-activated kinases, p38MAPK and c-Jun N-terminal kinase, (JNK) in human neuronal SH-SY5Y cells.	txm-cb13	0-8	presenilin 2	Homo sapiens	32-35
28764909-6	2017	The serine residue at codon 230 in PSEN1 is highly conserved across species and in PSEN2, providing strong evidence for its pathogenicity in this family.	Serine	4-10	presenilin 2	Homo sapiens	83-88
32254267-1	2018	This article describes a novel reduction degradable supramolecular nanoparticle gene delivery system via host-guest interaction based on cyclodextrin-conjugated polyaspartamide with disulfide linkage (Pasp-SS-CD) and adamantyl-terminated polyethylenimine (Ad4-PEI).	Cyclodextrins	137-149	presenilin 2	Homo sapiens	256-259
32254267-1	2018	This article describes a novel reduction degradable supramolecular nanoparticle gene delivery system via host-guest interaction based on cyclodextrin-conjugated polyaspartamide with disulfide linkage (Pasp-SS-CD) and adamantyl-terminated polyethylenimine (Ad4-PEI).	polyaspartamide	161-176	presenilin 2	Homo sapiens	256-259
32254267-1	2018	This article describes a novel reduction degradable supramolecular nanoparticle gene delivery system via host-guest interaction based on cyclodextrin-conjugated polyaspartamide with disulfide linkage (Pasp-SS-CD) and adamantyl-terminated polyethylenimine (Ad4-PEI).	Disulfides	182-191	presenilin 2	Homo sapiens	256-259
32254267-1	2018	This article describes a novel reduction degradable supramolecular nanoparticle gene delivery system via host-guest interaction based on cyclodextrin-conjugated polyaspartamide with disulfide linkage (Pasp-SS-CD) and adamantyl-terminated polyethylenimine (Ad4-PEI).	pasp-ss-cd	201-211	presenilin 2	Homo sapiens	256-259
32254267-2	2018	The reduction responsiveness of Pasp-SS-CD and the Pasp-SS-CD/Ad4-PEI/pDNA supramolecular nanoparticles (SNPs) in the presence of dl-dithiothreitol (DTT) was confirmed by SEC-MALLS and DLS analysis, respectively.	1,4-Dithiothreitol	130-147	presenilin 2	Homo sapiens	62-65
32254267-4	2018	It was found that introducing Pasp-SS-CD to assemble Ad4-PEI could substantially enhance the tolerance of protein adsorption and maintain the gene transfer capacity of polycationic carriers, which might be beneficial for in vivo use.	pasp-ss-cd	30-40	presenilin 2	Homo sapiens	53-56
29269871-5	2017	Depolarization and cAMP signals induce preferential transcription of activity-dependent genes containing promoters with proximal CRE/TATA sequences, such as c-fos, Dusp1, Nr4a1, Nr4a2 and Ptgs2, but not genes with proximal CRE/TATA-less promoters (e.g. Nr4a3, Presenilin-1 and Presenilin-2).	Cyclic AMP	19-23	presenilin 2	Homo sapiens	277-289
29085303-4	2017	PSs were shown to be present in mitochondria and particularly enriched in mitochondria-associated membranes (MAM), where PS2 is involved in the calcium shuttling between mitochondria and the endoplasmic reticulum (ER).	Calcium	144-151	presenilin 2	Homo sapiens	121-124
23952003-0	2013	Presenilin 2 influences miR146 level and activity in microglia.	mir146	24-30	presenilin 2	Homo sapiens	0-12
26422362-4	2015	Target region capture sequencing yielded a novel missense mutation at codon 123 (P123L) which is a heterozygous C to T point mutation at position 368 (c.368C>T) in exon 5 of the presenilin 2 leading to a proline-to-leucine substitution.	Proline	204-211	presenilin 2	Homo sapiens	178-190
26422362-4	2015	Target region capture sequencing yielded a novel missense mutation at codon 123 (P123L) which is a heterozygous C to T point mutation at position 368 (c.368C>T) in exon 5 of the presenilin 2 leading to a proline-to-leucine substitution.	Leucine	215-222	presenilin 2	Homo sapiens	178-190
25514462-7	2015	This is due to claudin-7 recruiting EpCAM in glycolipid-enriched membrane fractions towards claudin-7-associated TACE and presenilin2, which cleave EpCAM.	Glycolipids	45-55	presenilin 2	Homo sapiens	122-133
24363250-0	2014	Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.	Thapsigargin	0-12	presenilin 2	Homo sapiens	21-33
24838186-5	2014	Target region sequencing showed a novel missense mutation at codon 141 (N141Y) of the PSEN2 gene that predicts an Asparagine-to-Tyrosine substitution in the affected individuals.	Asparagine	114-124	presenilin 2	Homo sapiens	86-91
24838186-5	2014	Target region sequencing showed a novel missense mutation at codon 141 (N141Y) of the PSEN2 gene that predicts an Asparagine-to-Tyrosine substitution in the affected individuals.	Tyrosine	128-136	presenilin 2	Homo sapiens	86-91
24885952-3	2014	CASE PRESENTATION: PSEN2 mutation at codon 214 for predicting a valine to leucine substitution was found in a 70-year-old woman, who showed a dementia of the Alzheimer type.	Valine	64-70	presenilin 2	Homo sapiens	19-24
24885952-3	2014	CASE PRESENTATION: PSEN2 mutation at codon 214 for predicting a valine to leucine substitution was found in a 70-year-old woman, who showed a dementia of the Alzheimer type.	Leucine	74-81	presenilin 2	Homo sapiens	19-24
24885952-5	2014	We also predicted the structures of presenilin 2 protein with native Val 214 residue and Leu 214 mutation, which revealed significant structural changes in the region.	Valine	69-72	presenilin 2	Homo sapiens	36-48
24885952-5	2014	We also predicted the structures of presenilin 2 protein with native Val 214 residue and Leu 214 mutation, which revealed significant structural changes in the region.	Leucine	89-92	presenilin 2	Homo sapiens	36-48
23952003-7	2013	We identified miR146, a negative regulator of monocyte pro-inflammatory response, as constitutively down-regulated in PS2 KO microglia.	mir146	14-20	presenilin 2	Homo sapiens	118-121
23952003-8	2013	Consistent with a state of miR146 suppression, we found that PS2 KO microglia express higher levels of the miR146 target protein interleukin-1 receptor-associated kinase-1, and have increased NFkappaB transcriptional activity.	mir146	27-33	presenilin 2	Homo sapiens	61-64
23838183-5	2013	Furthermore, we showed that the Alzheimer"s disease-linked protein presenilin-2 and the channel protein ORAI2 prevented overload of ER Ca(2+) and that feedback from Ca(2+) to phosphatidylinositol 4-kinase and PLCdelta (phospholipase Cdelta) may regulate the abundance of the plasma membrane lipid PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to control Ca(2+) extrusion.	Phosphatidylinositol 4,5-Diphosphate	308-345	presenilin 2	Homo sapiens	67-79
23740990-3	2013	Using human monoclonal antibodies (MAbs), we have recently identified antigenic region 4 (AD-4) on gB as an important target for neutralizing antibodies.	gb	99-101	presenilin 2	Homo sapiens	90-94
23740990-6	2013	A tyrosine (Y) at position 364 and a lysine (K) at position 379 (the YK epitope), which are immediate neighbors on the AD-4 surface, were found to be essential for binding of the human MAbs.	Tyrosine	2-10	presenilin 2	Homo sapiens	119-123
23740990-6	2013	A tyrosine (Y) at position 364 and a lysine (K) at position 379 (the YK epitope), which are immediate neighbors on the AD-4 surface, were found to be essential for binding of the human MAbs.	Lysine	37-43	presenilin 2	Homo sapiens	119-123
23838183-5	2013	Furthermore, we showed that the Alzheimer"s disease-linked protein presenilin-2 and the channel protein ORAI2 prevented overload of ER Ca(2+) and that feedback from Ca(2+) to phosphatidylinositol 4-kinase and PLCdelta (phospholipase Cdelta) may regulate the abundance of the plasma membrane lipid PI(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to control Ca(2+) extrusion.	pi(4,5)p2	297-306	presenilin 2	Homo sapiens	67-79
23546527-2	2013	To investigate whether AD pathology induced by overexpression of human mutant presenilin 2 (PS2) protein induces changes in glucose metabolism, glucose-related factors were analyzed in the brain of 12-month-old neuron-specific enolase (NSE)/hPS2m transgenic (Tg) mice.	Glucose	124-131	presenilin 2	Homo sapiens	78-90
23667524-5	2013	PS1 and PS2 are required for efficient copper uptake in mammalian systems.	Copper	39-45	presenilin 2	Homo sapiens	8-11
23546527-4	2013	A significant increase of glucose levels accompanied by a decrease of insulin levels was detected in NSE/hPS2m Tg mice, while the expression levels of insulin receptors were significantly decreased in NSE/hPS2m Tg mice compared to the non-Tg littermates without affecting the insulin-like growth factor (IGF) receptor.	Glucose	26-33	presenilin 2	Homo sapiens	105-109
19382908-3	2009	By using HeLa, SH-SY5Y and MEFs as model cells, and recombinant aequorins as Ca(2+) probes, we show evidence that transient expression of either wild-type or mutant PS2 increases the passive Ca(2+) leakage: both ryanodine- and IP(3)-receptors contribute to Ca(2+) exit out of the ER, whereas the ribosome translocon complex is not involved.	Ryanodine	212-221	presenilin 2	Homo sapiens	165-168
22753229-6	2012	PS2 depletion also decreased the invasive capability of glioma cells and anchorage-independent colony formation in soft agar.	Agar	120-124	presenilin 2	Homo sapiens	0-3
22458507-1	2012	BACKGROUND: This study was conducted to evaluate the efficacy of the herbal formula PM012 on an Alzheimer"s disease model, human presenilin 2 mutant transgenic mice (hPS2m), and also to evaluate the toxicity of PM012 in Sprague-Dawely rats after 4 or 26 weeks treatment with repeated oral administration.	pm012	84-89	presenilin 2	Homo sapiens	129-141
22458507-5	2012	RESULTS: The results showed that PM012-treated hPS2m transgenic mice showed significantly reduced escape latency when compared with the hPS2m transgenic mice.	pm012	33-38	presenilin 2	Homo sapiens	47-51
21545304-3	2011	Presenilins (PSs) (presenilin 1 [ PS1] and presenilin 2 [PS2]) and apolipoprotein E (APOE) epsilon4 allele have been found to be potentially linked to Abeta accumulation and accrual in turn contributing for the AD pathology, despite their significant role in processing of amyloid precursor protein (APP) and lipid metabolism.	UNII-042A8N37WH	151-156	presenilin 2	Homo sapiens	43-55
21545304-3	2011	Presenilins (PSs) (presenilin 1 [ PS1] and presenilin 2 [PS2]) and apolipoprotein E (APOE) epsilon4 allele have been found to be potentially linked to Abeta accumulation and accrual in turn contributing for the AD pathology, despite their significant role in processing of amyloid precursor protein (APP) and lipid metabolism.	UNII-042A8N37WH	151-156	presenilin 2	Homo sapiens	57-60
21216226-1	2011	Calsenilin, a neuronal calcium binding protein that has been shown to have multiple functions in the cell, interacts with presenilin 1 (PS1) and presenilin 2 (PS2), represses gene transcription and binds to A-type voltage-gated potassium channels.	Calcium	23-30	presenilin 2	Homo sapiens	145-157
20375137-15	2010	In addition, a 58-year-old female with a 2 year course of cognitive decline and no family history of dementia has abnormal fludeoxyglucose-positron emission tomography imaging and a novel 2 base pair deletion in presenilin 2 at nucleotide 342/343, predicted to produce a frame-shift and premature termination.	2-Deoxy-2-fluoro-D-glucose	123-138	presenilin 2	Homo sapiens	212-224
20421691-2	2010	We have discovered that mitochondria-associated membranes (MAM) - a specialized subcompartment of the endoplasmic reticulum (ER) involved in lipid metabolism and calcium homeostasis that physically connects ER to mitochondria - is the predominant subcellular location for PS1 and PS2, and for gamma-secretase activity.	Calcium	162-169	presenilin 2	Homo sapiens	280-283
22470521-11	2012	Equally, knock-out of the presenilin genes, presenilin 1 and presenilin 2, essential for Abeta and AICD production, or of APP itself, increased GD3S activity and expression and consequently resulted in a major shift of a- to b-series gangliosides.	Gangliosides	234-246	presenilin 2	Homo sapiens	61-73
19306098-2	2009	PSEN1 and PSEN2 are essential components of the gamma-secretase complex, which cleaves APP to affect Abeta processing.	UNII-042A8N37WH	101-106	presenilin 2	Homo sapiens	10-15
17186461-14	2006	Calcium signaling was altered in cultured skin fibroblasts from PSEN1 and PSEN2 mutation carriers.	Calcium	0-7	presenilin 2	Homo sapiens	74-79
18082636-0	2008	N-acetylcysteine amide (AD4) attenuates oxidative stress in beta-thalassemia blood cells.	N-Acetylcysteinamide	0-22	presenilin 2	Homo sapiens	24-27
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	Sulfhydryl Compounds	39-44	presenilin 2	Homo sapiens	79-82
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	N-Acetylcysteinamide	55-77	presenilin 2	Homo sapiens	79-82
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	Amides	72-77	presenilin 2	Homo sapiens	79-82
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	Acetylcysteine	103-120	presenilin 2	Homo sapiens	79-82
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	Acetylcysteine	122-125	presenilin 2	Homo sapiens	79-82
18082636-3	2008	Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.	Glutathione	132-143	presenilin 2	Homo sapiens	107-110
18082636-3	2008	Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.	Glutathione	145-148	presenilin 2	Homo sapiens	107-110
18082636-3	2008	Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.	ros	252-255	presenilin 2	Homo sapiens	107-110
17614368-3	2007	In the present study, we examined whether ubiquitination of presenilin-2 (PS2) is required for interaction with ubiquilin-1 by mutating lysine residues that may be targets for ubiquitination in the presenilin loop and carboxyl terminus regions.	Lysine	136-142	presenilin 2	Homo sapiens	60-72
17614368-4	2007	Mutation of two lysine residues in the PS2-loop region suggested that ubiquitination is not required for interaction with ubiquilin-1 and may, in fact, even negatively regulate the interaction.	Lysine	16-22	presenilin 2	Homo sapiens	39-42
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Lysine	61-67	presenilin 2	Homo sapiens	105-108
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Lysine	61-67	presenilin 2	Homo sapiens	224-227
17614368-6	2007	Instead, we found that the mutation of either one of the two lysine residues in the carboxyl terminus of PS2 or the proline residues in the highly conserved PALP motif in this region results in destabilization of the mutant PS2 polypeptides because of increased degradation by the proteasome.	Proline	116-123	presenilin 2	Homo sapiens	224-227
17663636-5	2007	The presence of 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate (CHAPSO) detergent in lysates favored preservation of PS1 and PS2 native protein complexes.	chapso	16-83	presenilin 2	Homo sapiens	146-149
17663636-5	2007	The presence of 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate (CHAPSO) detergent in lysates favored preservation of PS1 and PS2 native protein complexes.	chapso	85-91	presenilin 2	Homo sapiens	146-149
17663636-6	2007	We compared Kyte-Doolittle hydropathicity profiles and hydrophobic interactions of PS1 and PS2 with phenyl-agarose.	phenyl-sepharose	100-114	presenilin 2	Homo sapiens	91-94
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	Dinoprostone	77-98	presenilin 2	Homo sapiens	192-195
16331303-5	2006	The clinical relevance of this finding was confirmed by the evidence that COX-2 protein and PG-E2 concentrations were selectively increased >2-fold in the cerebral cortex of subjects harboring the N141I PS2 FAD mutation relative to wild-type PS2 AD cases.	Dinoprostone	92-97	presenilin 2	Homo sapiens	203-206
16331303-4	2006	Most interestingly, we found that inhibition of COX-2-mediated generation of prostaglandin (PG)-E2 in H4 neuronal cells with the preferential COX-2 inhibitor nimesulide protects against N141I PS2-mediated apoptotic cell death coincidental with an inhibition of GSK-3beta activity and subsequent normalization of beta-catenin cellular distribution.	nimesulide	158-168	presenilin 2	Homo sapiens	192-195
16155344-4	2005	Moreover, we observed similarly reduced taxol/GTP-stimulated tubulin polymerization from gray matter obtained from patients with AD caused by PSEN2 N141I mutation or frontotemporal dementia with parkinsonism linked to chromosome-17 caused (FTDP-17) by TAU V337M or P301L mutation.	Paclitaxel	40-45	presenilin 2	Homo sapiens	142-147
17401156-0	2006	Changes in cholesterol metabolism are associated with PS1 and PS2 gene regulation in SK-N-BE.	Cholesterol	11-22	presenilin 2	Homo sapiens	62-65
17401156-7	2006	In the absence of exogenous lipids, cell PS1 and PS2 expression was induced by LDL and by lysosomal sequestration of cholesterol.	Cholesterol	117-128	presenilin 2	Homo sapiens	49-52
17401156-8	2006	However, a different pattern of induction of presenilin gene expression was observed in the latter condition, suggesting that lysosomal cholesterol levels are strong inducers of PS2 transcription.	Cholesterol	136-147	presenilin 2	Homo sapiens	178-181
16155344-4	2005	Moreover, we observed similarly reduced taxol/GTP-stimulated tubulin polymerization from gray matter obtained from patients with AD caused by PSEN2 N141I mutation or frontotemporal dementia with parkinsonism linked to chromosome-17 caused (FTDP-17) by TAU V337M or P301L mutation.	Guanosine Triphosphate	46-49	presenilin 2	Homo sapiens	142-147
16258850-9	2005	Moreover, the levels of green fluorescence on hSelM fusion protein with EGFP were suppressed in the cells transfected with hPS2m, and its levels had actually increased by treatments of sodium selenite.	Sodium Selenite	185-200	presenilin 2	Homo sapiens	123-127
15685448-9	2005	By two-hybrid screening, we found that 6-16 protein interacts with calcium and integrin binding protein, CIB/KIP/Calmyrin (CIB), which interacts with presenilin 2, a protein involved in Alzheimer"s disease.	Calcium	67-74	presenilin 2	Homo sapiens	150-162
15280425-9	2004	Furthermore, presenilin deficiency leads to abnormally glycosylated NRADD and overexpression of presenilin 2 inhibits NRADD maturation, which is dependent on the putative active site residue D366 but not on gamma-secretase activity.	d366	191-195	presenilin 2	Homo sapiens	96-108
20641912-0	2004	3-(3-(3-[(18)F]Flouropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine The current state of molecular genetics of Alzheimer"s disease (AD) focuses on four genes: the beta-amyloid precursor protein (beta-APP) gene, the presenilin 1 gene, the presenilin 2 gene, and the apolipoprotein E (APOE) gene (2).	3-(3-(3-[(18)f]flouropropyl)thio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine	0-92	presenilin 2	Homo sapiens	263-275
15763173-2	2005	Calsenilin, a calcium binding protein that has been shown to interact with the C-termini of both presenilin 1 (PS1) and presenilin 2 (PS2), appears to play a role in transcriptional regulation and apoptosis and to bind to A-type voltage-gated potassium channels.	Calcium	14-21	presenilin 2	Homo sapiens	120-132
15763173-2	2005	Calsenilin, a calcium binding protein that has been shown to interact with the C-termini of both presenilin 1 (PS1) and presenilin 2 (PS2), appears to play a role in transcriptional regulation and apoptosis and to bind to A-type voltage-gated potassium channels.	Calcium	14-21	presenilin 2	Homo sapiens	134-137
15885068-1	2005	The EF-hand calcium binding protein Calmyrin (also called CIB-1) was shown to interact with presenilin-2 (PS-2), suggesting that this interaction might play a role in the pathogenesis of Alzheimer"s disease (AD).	Calcium	12-19	presenilin 2	Homo sapiens	92-104
15885068-1	2005	The EF-hand calcium binding protein Calmyrin (also called CIB-1) was shown to interact with presenilin-2 (PS-2), suggesting that this interaction might play a role in the pathogenesis of Alzheimer"s disease (AD).	Calcium	12-19	presenilin 2	Homo sapiens	106-110
15601622-8	2005	In cells coexpressing presenilin2 or the FAD-linked presenilin2 variants, Ca(2+) entry through TRPC6 could still be induced by direct activation of TRPC6 with 1-oleoyl-2-acetyl-sn-glycerol (OAG).	1-oleoyl-2-acetylglycerol	159-188	presenilin 2	Homo sapiens	22-33
15601622-8	2005	In cells coexpressing presenilin2 or the FAD-linked presenilin2 variants, Ca(2+) entry through TRPC6 could still be induced by direct activation of TRPC6 with 1-oleoyl-2-acetyl-sn-glycerol (OAG).	1-oleoyl-2-acetylglycerol	159-188	presenilin 2	Homo sapiens	52-63
15601622-8	2005	In cells coexpressing presenilin2 or the FAD-linked presenilin2 variants, Ca(2+) entry through TRPC6 could still be induced by direct activation of TRPC6 with 1-oleoyl-2-acetyl-sn-glycerol (OAG).	1-oleoyl-2-acetylglycerol	190-193	presenilin 2	Homo sapiens	22-33
15601622-8	2005	In cells coexpressing presenilin2 or the FAD-linked presenilin2 variants, Ca(2+) entry through TRPC6 could still be induced by direct activation of TRPC6 with 1-oleoyl-2-acetyl-sn-glycerol (OAG).	1-oleoyl-2-acetylglycerol	190-193	presenilin 2	Homo sapiens	52-63
15601622-9	2005	Furthermore, transient coexpression of a loss-of-function PS2 mutant and TRPC6 in HEK293T cells enhanced angiotensin II (AngII)- and OAG-induced Ca(2+) entry.	1-oleoyl-2-acetylglycerol	133-136	presenilin 2	Homo sapiens	58-61
15733082-3	2005	We now report that AD4, the novel low molecular weight thiol antioxidant and the N-acytel cysteine (NAC) related compound, is capable of penetrating the brain and protects neurons in general and especially dopaminergic cells against various OS-generating neurotoxins in tissue cultures.	Sulfhydryl Compounds	55-60	presenilin 2	Homo sapiens	19-22
15733082-3	2005	We now report that AD4, the novel low molecular weight thiol antioxidant and the N-acytel cysteine (NAC) related compound, is capable of penetrating the brain and protects neurons in general and especially dopaminergic cells against various OS-generating neurotoxins in tissue cultures.	n-acytel cysteine	81-98	presenilin 2	Homo sapiens	19-22
15733082-3	2005	We now report that AD4, the novel low molecular weight thiol antioxidant and the N-acytel cysteine (NAC) related compound, is capable of penetrating the brain and protects neurons in general and especially dopaminergic cells against various OS-generating neurotoxins in tissue cultures.	nac	100-103	presenilin 2	Homo sapiens	19-22
15733082-5	2005	AD4 suppressed amphetamine-induced rotational behaviour in rats with unilateral 6-OHDA-induced nigral lesion.	Amphetamine	15-26	presenilin 2	Homo sapiens	0-3
15733082-5	2005	AD4 suppressed amphetamine-induced rotational behaviour in rats with unilateral 6-OHDA-induced nigral lesion.	Oxidopamine	80-86	presenilin 2	Homo sapiens	0-3
15475008-0	2004	Calcium binding sequences in calmyrin regulates interaction with presenilin-2.	Calcium	0-7	presenilin 2	Homo sapiens	65-77
15475008-11	2004	Our results suggest that calmyrin functions as a calcium sensor and that calcium binding sequences in calmyrin are important for interaction with the PS2 loop.	Calcium	49-56	presenilin 2	Homo sapiens	150-153
15475008-11	2004	Our results suggest that calmyrin functions as a calcium sensor and that calcium binding sequences in calmyrin are important for interaction with the PS2 loop.	Calcium	73-80	presenilin 2	Homo sapiens	150-153
15264228-3	2004	M239V-PS2 exerted three forms of cytotoxicity: one was sensitive to both an antioxidant glutathione-ethyl-ester (GEE) and a caspase inhibitor Ac-DEVD-CHO (DEVD); the second was sensitive to GEE but resistant to DEVD; and the third was resistant to both.	S-ethyl glutathione	88-111	presenilin 2	Homo sapiens	6-9
15264228-3	2004	M239V-PS2 exerted three forms of cytotoxicity: one was sensitive to both an antioxidant glutathione-ethyl-ester (GEE) and a caspase inhibitor Ac-DEVD-CHO (DEVD); the second was sensitive to GEE but resistant to DEVD; and the third was resistant to both.	S-ethyl glutathione	113-116	presenilin 2	Homo sapiens	6-9
15264228-3	2004	M239V-PS2 exerted three forms of cytotoxicity: one was sensitive to both an antioxidant glutathione-ethyl-ester (GEE) and a caspase inhibitor Ac-DEVD-CHO (DEVD); the second was sensitive to GEE but resistant to DEVD; and the third was resistant to both.	DEVD	145-149	presenilin 2	Homo sapiens	6-9
15264228-3	2004	M239V-PS2 exerted three forms of cytotoxicity: one was sensitive to both an antioxidant glutathione-ethyl-ester (GEE) and a caspase inhibitor Ac-DEVD-CHO (DEVD); the second was sensitive to GEE but resistant to DEVD; and the third was resistant to both.	DEVD	155-159	presenilin 2	Homo sapiens	6-9
15264228-4	2004	The GEE/DEVD-sensitive cytotoxicity by M239V-PS2 was likely through NADPH oxidase and the GEE-sensitive/DEVD-resistant cytotoxicity through xanthine oxidase (XO).	S-ethyl glutathione	4-7	presenilin 2	Homo sapiens	45-48
15264228-4	2004	The GEE/DEVD-sensitive cytotoxicity by M239V-PS2 was likely through NADPH oxidase and the GEE-sensitive/DEVD-resistant cytotoxicity through xanthine oxidase (XO).	DEVD	8-12	presenilin 2	Homo sapiens	45-48
15264228-4	2004	The GEE/DEVD-sensitive cytotoxicity by M239V-PS2 was likely through NADPH oxidase and the GEE-sensitive/DEVD-resistant cytotoxicity through xanthine oxidase (XO).	S-ethyl glutathione	90-93	presenilin 2	Homo sapiens	45-48
15264228-8	2004	Notably, cytotoxicity by M239V-PS2 could be inhibited by the combination of two clinically usable inhibitors of superoxide-generating enzymes, apocynin and oxypurinol.	Superoxides	112-122	presenilin 2	Homo sapiens	31-34
15264228-8	2004	Notably, cytotoxicity by M239V-PS2 could be inhibited by the combination of two clinically usable inhibitors of superoxide-generating enzymes, apocynin and oxypurinol.	acetovanillone	143-151	presenilin 2	Homo sapiens	31-34
15264228-8	2004	Notably, cytotoxicity by M239V-PS2 could be inhibited by the combination of two clinically usable inhibitors of superoxide-generating enzymes, apocynin and oxypurinol.	Oxypurinol	156-166	presenilin 2	Homo sapiens	31-34
12770698-3	2003	A recent study demonstrated that the deletion of adenosine in the promoter region of the presenilin 2 gene (PS2) is a susceptibility factor for early-onset AD.	Adenosine	49-58	presenilin 2	Homo sapiens	89-101
15004330-9	2004	Immunoprecipitation studies indicated that ubiquilin-1 overexpression decreases ubiquitination of coexpressed PS2 proteins, suggesting that binding of ubiquilin might block ubiquitin chain elongation.	ubiquilin	43-52	presenilin 2	Homo sapiens	110-113
12925374-9	2003	RESULTS: We found a missense mutation at codon 430 of the PSEN2 gene that predicts a threonine-to-methionine substitution.	Threonine	85-94	presenilin 2	Homo sapiens	58-63
12925374-9	2003	RESULTS: We found a missense mutation at codon 430 of the PSEN2 gene that predicts a threonine-to-methionine substitution.	Methionine	98-108	presenilin 2	Homo sapiens	58-63
15055444-3	2004	We report the clinical and neuropathological phenotype of FLO10, the large Italian Alzheimer kindred associated with methionine to valine substitution at residue 239 of presenilin 2.	flo10	58-63	presenilin 2	Homo sapiens	169-181
15055444-8	2004	These observations indicate that the Alzheimer kindred FLO10 associated with M239V mutation of presenilin 2 is characterized by some peculiarities of the clinical and neuropathologic phenotype compared to sporadic Alzheimer disease.	flo10	55-60	presenilin 2	Homo sapiens	95-107
12938025-4	2003	We demonstrated that the inhibition of energy metabolism by sodium azide down-regulates PS2 gene expression through modification of promoter activity.	Sodium Azide	60-72	presenilin 2	Homo sapiens	88-91
12938025-6	2003	Azide effect on PS2 expression was completely inhibited by the addition of an antioxidant suggesting that the imbalance of the cellular redox homeostasis modulates the expression of this gene.	Azides	0-5	presenilin 2	Homo sapiens	16-19
12770698-3	2003	A recent study demonstrated that the deletion of adenosine in the promoter region of the presenilin 2 gene (PS2) is a susceptibility factor for early-onset AD.	Adenosine	49-58	presenilin 2	Homo sapiens	108-111
12646573-0	2003	Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.	nicastrin	91-100	presenilin 2	Homo sapiens	17-29
12646573-5	2003	In contrast, absence of presenilin 2 (PS2) is associated with only modest reductions in the levels of immature nicastrin.	nicastrin	111-120	presenilin 2	Homo sapiens	24-36
12646573-5	2003	In contrast, absence of presenilin 2 (PS2) is associated with only modest reductions in the levels of immature nicastrin.	nicastrin	111-120	presenilin 2	Homo sapiens	38-41
12646573-7	2003	Our data therefore suggest that the differential interactions of PS1 and PS2 with nicastrin reflect different functions for the PS1 and PS2 complexes.	nicastrin	82-91	presenilin 2	Homo sapiens	73-76
12646573-7	2003	Our data therefore suggest that the differential interactions of PS1 and PS2 with nicastrin reflect different functions for the PS1 and PS2 complexes.	nicastrin	82-91	presenilin 2	Homo sapiens	136-139
12556443-0	2003	The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.	Staurosporine	62-75	presenilin 2	Homo sapiens	27-39
12556443-3	2003	We show first that overexpression of the presenilinase-derived maturation product of presenilin 2 (CTF-PS2) increases Abeta recovery, the production of which is almost abolished by a caspase 3 inhibitor and increased by staurosporine.	ctf-ps2	99-106	presenilin 2	Homo sapiens	85-97
12556443-3	2003	We show first that overexpression of the presenilinase-derived maturation product of presenilin 2 (CTF-PS2) increases Abeta recovery, the production of which is almost abolished by a caspase 3 inhibitor and increased by staurosporine.	Staurosporine	220-233	presenilin 2	Homo sapiens	85-97
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Trypan Blue	190-201	presenilin 2	Homo sapiens	45-57
12605888-7	2003	We also examined the susceptibility of the PS2-transfected cells to apoptosis induced by the apoptotic inducers staurosporine and H(2)O(2).	Staurosporine	112-125	presenilin 2	Homo sapiens	43-46
12605888-7	2003	We also examined the susceptibility of the PS2-transfected cells to apoptosis induced by the apoptotic inducers staurosporine and H(2)O(2).	h(2)o	130-135	presenilin 2	Homo sapiens	43-46
12484344-10	2002	Leucine at position 174 is highly conserved among species and is identical in presenilin 1 and presenilin 2 proteins.	Leucine	0-7	presenilin 2	Homo sapiens	95-107
12147673-8	2002	Inactivating PS1 or PS2 function by mutagenesis of one of the critical aspartate residues or by gamma-secretase inhibitors results in delayed reinternalization of the beta-amyloid precursor protein and its accumulation at the cell surface.	Aspartic Acid	71-80	presenilin 2	Homo sapiens	20-23
11904448-6	2002	We also establish that wild-type- and mutated PS2-induced caspase activation is reduced by p53 antisense approach and by pifithrin-alpha, a chemical inhibitor of p53.	pifithrin	121-136	presenilin 2	Homo sapiens	46-49
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Trypan Blue	190-201	presenilin 2	Homo sapiens	59-62
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid	213-309	presenilin 2	Homo sapiens	45-57
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid	213-309	presenilin 2	Homo sapiens	59-62
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Propidium	329-345	presenilin 2	Homo sapiens	45-57
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Propidium	329-345	presenilin 2	Homo sapiens	59-62
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Aspartic Acid	112-121	presenilin 2	Homo sapiens	54-66
11861776-4	2002	Since both mechanisms were sensitive to a cell-permeable antioxidant, we examined potential sources of reactive oxygen species in each mechanism, and found that the caspase inhibitor-sensitive neurotoxicity by N141I-PS2 was likely through NADPH oxidase and the caspase inhibitor-resistant neurotoxicity by N141I-PS2 through xanthine oxidase.	Reactive Oxygen Species	103-126	presenilin 2	Homo sapiens	216-219
11731004-4	2001	Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event.	CHEMBL408967	103-106	presenilin 2	Homo sapiens	38-41
11731004-4	2001	Interestingly, the phosphorylation of PS2 modulates the production of the smaller, caspase-derived PS2 CTF, which indicates that the generation of this fragment is a regulated, physiologic event.	CHEMBL408967	103-106	presenilin 2	Homo sapiens	99-102
11731004-6	2001	Because this fragment is normally present at levels that are difficult to detect, we have used cell lines in which the production of wild-type or N141I mutant PS2 is controlled by a tetracycline-regulated promoter in order to assess the subcellular localization of the caspase CTF in relation to the larger, constitutive PS2 CTF and to PS2 holoprotein.	Tetracycline	182-194	presenilin 2	Homo sapiens	159-162
12232783-2	2002	Direct sequencing analysis detected a common single adenine (A) nucleotide deletion polymorphism in the upstream promoter region of the PSEN2 gene.	Adenine Nucleotides	52-74	presenilin 2	Homo sapiens	136-141
12232783-8	2002	These results suggest that under Pl and oxygen stress conditions relatively minor variations in PSEN2 promoter DNA sequence structure can enhance PSEN2 gene expression and that consequently these may play a role in the induction and/or proliferation of a Pl response in AD brain.	Oxygen	40-46	presenilin 2	Homo sapiens	96-101
12232783-8	2002	These results suggest that under Pl and oxygen stress conditions relatively minor variations in PSEN2 promoter DNA sequence structure can enhance PSEN2 gene expression and that consequently these may play a role in the induction and/or proliferation of a Pl response in AD brain.	Oxygen	40-46	presenilin 2	Homo sapiens	146-151
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Aspartic Acid	112-121	presenilin 2	Homo sapiens	68-73
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Alanine	125-132	presenilin 2	Homo sapiens	54-66
11723295-1	2001	The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).	Alanine	125-132	presenilin 2	Homo sapiens	68-73
11444983-8	2001	Pepstatin-biotin was also shown to bind to PS2.	pepstatin-biotin	0-16	presenilin 2	Homo sapiens	43-46
11432849-2	2001	PS is an evolutionarily conserved multipass transmembrane protein, and all known PS proteins contain a proline-alanine-leucine-proline (PALP) motif starting at proline (P) 414 (amino acid numbering based on human PS2) at the C terminus.	Proline	103-110	presenilin 2	Homo sapiens	213-216
11432849-2	2001	PS is an evolutionarily conserved multipass transmembrane protein, and all known PS proteins contain a proline-alanine-leucine-proline (PALP) motif starting at proline (P) 414 (amino acid numbering based on human PS2) at the C terminus.	Leucine	119-126	presenilin 2	Homo sapiens	213-216
10748169-0	2000	Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.	sorcin	28-34	presenilin 2	Homo sapiens	0-12
11278424-1	2001	Calsenilin is a member of the recoverin family of neuronal calcium-binding proteins that we have previously shown to interact with presenilin 1 (PS1) and presenilin 2 (PS2) holoproteins.	Calcium	59-66	presenilin 2	Homo sapiens	154-166
11278424-1	2001	Calsenilin is a member of the recoverin family of neuronal calcium-binding proteins that we have previously shown to interact with presenilin 1 (PS1) and presenilin 2 (PS2) holoproteins.	Calcium	59-66	presenilin 2	Homo sapiens	168-171
11278424-12	2001	Interestingly, when the 25-kDa PS2 CTF and the 20-kDa PS2 CTF are both present, calsenilin preferentially interacts with the 20-kDa CTF.	CHEMBL408967	35-38	presenilin 2	Homo sapiens	31-34
11076969-4	2000	Yeast two-hybrid (Y2H) interaction, glutathione S-transferase pull-down experiments, and colocalization of the proteins expressed in vivo, together with coimmunoprecipitation and cell fractionation studies, provide compelling evidence that ubiquilin interacts with both PS1 and PS2.	ubiquilin	240-249	presenilin 2	Homo sapiens	278-281
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 2	Homo sapiens	109-121
10856299-0	2000	Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-31	presenilin 2	Homo sapiens	109-121
10856299-5	2000	Aspartate mutant presenilin holoproteins also preclude entry of endogenous wild type PS1/PS2 into the high MW complexes but do not affect the incorporation of wild type holoproteins into lower MW holoprotein complexes.	Aspartic Acid	0-9	presenilin 2	Homo sapiens	89-92
11055438-1	2000	We studied a novel function of the presenilins (PS1 and PS2) in governing capacitative calcium entry (CCE), a refilling mechanism for depleted intracellular calcium stores.	Calcium	87-94	presenilin 2	Homo sapiens	56-59
11055438-1	2000	We studied a novel function of the presenilins (PS1 and PS2) in governing capacitative calcium entry (CCE), a refilling mechanism for depleted intracellular calcium stores.	Calcium	157-164	presenilin 2	Homo sapiens	56-59
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Methionine	138-148	presenilin 2	Homo sapiens	90-102
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Methionine	138-148	presenilin 2	Homo sapiens	104-107
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Methionine	138-148	presenilin 2	Homo sapiens	115-120
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Methionine	138-148	presenilin 2	Homo sapiens	173-176
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	90-102
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	104-107
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	115-120
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Isoleucine	152-162	presenilin 2	Homo sapiens	173-176
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Valine	219-225	presenilin 2	Homo sapiens	90-102
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Valine	219-225	presenilin 2	Homo sapiens	104-107
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Valine	219-225	presenilin 2	Homo sapiens	115-120
10822446-1	2000	In a family with autopsy-confirmed Alzheimer disease, the authors found a mutation in the presenilin 2 (PS2) gene (PSEN2) that predicts a methionine-to-isoleucine change at PS2 residue 239 (M239I), at which a change to valine was known in another family.	Valine	219-225	presenilin 2	Homo sapiens	173-176
10748169-2	2000	We report here the molecular interaction of the large hydrophilic loop region of presenilin 2 (PS2) with sorcin, a penta-EF-hand Ca(2+)-binding protein that serves as a modulator of the ryanodine receptor intracellular Ca(2+) channel.	sorcin	105-111	presenilin 2	Homo sapiens	81-93
10748169-2	2000	We report here the molecular interaction of the large hydrophilic loop region of presenilin 2 (PS2) with sorcin, a penta-EF-hand Ca(2+)-binding protein that serves as a modulator of the ryanodine receptor intracellular Ca(2+) channel.	sorcin	105-111	presenilin 2	Homo sapiens	95-98
10748169-5	2000	Sorcin was found to interact with PS2 endoproteolytic fragments but not full-length PS2, and the sorcin/PS2 interaction was greatly enhanced by treatment with the Ca(2+) ionophore A23187.	sorcin	0-6	presenilin 2	Homo sapiens	34-37
10748169-5	2000	Sorcin was found to interact with PS2 endoproteolytic fragments but not full-length PS2, and the sorcin/PS2 interaction was greatly enhanced by treatment with the Ca(2+) ionophore A23187.	Calcimycin	180-186	presenilin 2	Homo sapiens	34-37
9813158-5	1998	Interestingly, two selective proteasome inhibitors, Z-IE(Ot-Bu)A-Leucinal and lactacystin potentiate the APPalpha secretion observed in wtPS2-expressing cells and further amplify the N141I-PS2-induced decrease in APPalpha production.	lactacystin	78-89	presenilin 2	Homo sapiens	138-141
11261807-0	2000	Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes.	Aspartic Acid	22-32	presenilin 2	Homo sapiens	71-83
11261807-5	2000	Aspartate-mutant presenilin holoproteins also preclude entry of endogenous wild-type PS1/PS2 into the high molecular weight complexes, but do not affect the incorporation of wild-type holoproteins into lower molecular weight holoprotein complexes.	Aspartic Acid	0-9	presenilin 2	Homo sapiens	89-92
10575009-5	1999	Mutational analysis of the PS2 cleavage site indicates that the principal endoproteolytic cleavage occurs at residues Met-298/Val-299 and that the N terminus is subsequently modified by secondary proteolytic cleavages.	Methionine	118-121	presenilin 2	Homo sapiens	27-30
10575009-5	1999	Mutational analysis of the PS2 cleavage site indicates that the principal endoproteolytic cleavage occurs at residues Met-298/Val-299 and that the N terminus is subsequently modified by secondary proteolytic cleavages.	Valine	126-129	presenilin 2	Homo sapiens	27-30
10551803-0	1999	Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals.	Inositol 1,4,5-Trisphosphate	58-87	presenilin 2	Homo sapiens	0-12
10551803-0	1999	Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals.	Calcium	97-104	presenilin 2	Homo sapiens	0-12
10393846-4	1999	BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells.	Bromodeoxyuridine	0-4	presenilin 2	Homo sapiens	68-80
10393846-4	1999	BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells.	Bromodeoxyuridine	0-4	presenilin 2	Homo sapiens	82-85
10393846-4	1999	BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells.	Bromodeoxyuridine	0-4	presenilin 2	Homo sapiens	140-143
10393846-4	1999	BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells.	Bromodeoxyuridine	0-4	presenilin 2	Homo sapiens	140-143
10393846-4	1999	BrdU labeling was decreased in cells expressing presenilin-1 (PS1), presenilin-2 (PS2), an Alzheimer"s disease-associated missense mutation PS2(N141I), and the carboxyl-terminally deleted PS2 construct PS2(166aa), compared with mock and neurofilament-light (NF-L) transfected cells.	Bromodeoxyuridine	0-4	presenilin 2	Homo sapiens	140-143
9990034-5	1999	Recently, we found that the CTF of PS-2 is phosphorylated in vivo.	CHEMBL408967	28-31	presenilin 2	Homo sapiens	35-39
9990034-6	1999	We mapped the in vivo phosphorylation sites of PS-2 to serine residues 327 and 330, which are localized immediately adjacent to the cleavage sites of caspases after aspartate residues 326 and 329.	Serine	55-61	presenilin 2	Homo sapiens	47-51
9990034-6	1999	We mapped the in vivo phosphorylation sites of PS-2 to serine residues 327 and 330, which are localized immediately adjacent to the cleavage sites of caspases after aspartate residues 326 and 329.	Aspartic Acid	165-174	presenilin 2	Homo sapiens	47-51
10652302-4	2000	Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1.	Aspartic Acid	30-40	presenilin 2	Homo sapiens	44-47
10652302-4	2000	Here, we show that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1.	Aspartic Acid	30-40	presenilin 2	Homo sapiens	128-131
10652302-5	2000	Cells stably co-expressing TM Asp --> Ala mutations in both PS1 and PS2 show further accumulation of the APP-derived gamma-secretase substrates, C83 and C99.	Aspartic Acid	30-33	presenilin 2	Homo sapiens	71-74
10652302-5	2000	Cells stably co-expressing TM Asp --> Ala mutations in both PS1 and PS2 show further accumulation of the APP-derived gamma-secretase substrates, C83 and C99.	Alanine	41-44	presenilin 2	Homo sapiens	71-74
10652302-7	2000	Furthermore, endoproteolysis of the exogenous Asp mutant PS2 is absent, and endogenous PS1 C-terminal fragments are diminished to undetectable levels.	Aspartic Acid	46-49	presenilin 2	Homo sapiens	57-60
10652302-8	2000	Therefore, the co-expression of PS1 and PS2 TM Asp --> Ala mutants suppresses the formation of any detectable PS1 or PS2 heterodimeric fragments and essentially abolishes the production of Abeta.	Alanine	58-61	presenilin 2	Homo sapiens	40-43
10652302-8	2000	Therefore, the co-expression of PS1 and PS2 TM Asp --> Ala mutants suppresses the formation of any detectable PS1 or PS2 heterodimeric fragments and essentially abolishes the production of Abeta.	Alanine	58-61	presenilin 2	Homo sapiens	120-123
10349860-6	1999	Hypoxia-mediated induction of this splice variant was blocked by pretreatment of neuroblastoma cells with the protein synthesis inhibitor cycloheximide or antioxidants such as N-acetylcysteine and diphenyl iodonium, suggesting that hypoxia-mediated oxidant stress might, at least in part, underlie the alternative splicing of PS-2 mRNA through de novo protein synthesis.	Cycloheximide	138-151	presenilin 2	Homo sapiens	326-330
10349860-6	1999	Hypoxia-mediated induction of this splice variant was blocked by pretreatment of neuroblastoma cells with the protein synthesis inhibitor cycloheximide or antioxidants such as N-acetylcysteine and diphenyl iodonium, suggesting that hypoxia-mediated oxidant stress might, at least in part, underlie the alternative splicing of PS-2 mRNA through de novo protein synthesis.	Acetylcysteine	176-192	presenilin 2	Homo sapiens	326-330
10349860-6	1999	Hypoxia-mediated induction of this splice variant was blocked by pretreatment of neuroblastoma cells with the protein synthesis inhibitor cycloheximide or antioxidants such as N-acetylcysteine and diphenyl iodonium, suggesting that hypoxia-mediated oxidant stress might, at least in part, underlie the alternative splicing of PS-2 mRNA through de novo protein synthesis.	diphenyliodonium	197-214	presenilin 2	Homo sapiens	326-330
9813158-8	1998	This protection against proteasomal degradation directly modulates the APPalpha secretion response elicited by wt- and FAD-linked PS2 expression in human HEK293 cells.	Flavin-Adenine Dinucleotide	119-122	presenilin 2	Homo sapiens	130-133
8901624-5	1996	It is shown here, using cultured cells transfected for each of these proteins, that beta-APP binds specifically and transcellularly to either S182 or STM2.	beta-app	84-92	presenilin 2	Homo sapiens	150-154
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	20-23
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	101-104
9219695-3	1997	In cells expressing PS2 containing the asparagine-141 FAD mutant, the ratio of alternative to normal PS2 cleavage fragments was increased relative to wild-type PS2-expressing cells, suggesting a potential role for apoptosis-associated cleavage of presenilins in the pathogenesis of Alzheimer"s disease.	Asparagine	39-49	presenilin 2	Homo sapiens	101-104
9110991-4	1997	For regulated expression of PS2, we have established inducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactivator.	Tetracycline	120-132	presenilin 2	Homo sapiens	28-31
9110991-4	1997	For regulated expression of PS2, we have established inducible cell lines expressing PS2 under the tight control of the tetracycline-responsive transactivator.	Tetracycline	120-132	presenilin 2	Homo sapiens	85-88
9110991-7	1997	PS2 is polyubiquitinated in vivo, and the degradation of PS2 is inhibited by proteasome inhibitors, N-acetyl-L-leucinal-L-norleucinal and lactacystin.	-acetyl-l-leucinal-	101-120	presenilin 2	Homo sapiens	0-3
9110991-7	1997	PS2 is polyubiquitinated in vivo, and the degradation of PS2 is inhibited by proteasome inhibitors, N-acetyl-L-leucinal-L-norleucinal and lactacystin.	-acetyl-l-leucinal-	101-120	presenilin 2	Homo sapiens	57-60
9110991-7	1997	PS2 is polyubiquitinated in vivo, and the degradation of PS2 is inhibited by proteasome inhibitors, N-acetyl-L-leucinal-L-norleucinal and lactacystin.	lactacystin	138-149	presenilin 2	Homo sapiens	0-3
9110991-7	1997	PS2 is polyubiquitinated in vivo, and the degradation of PS2 is inhibited by proteasome inhibitors, N-acetyl-L-leucinal-L-norleucinal and lactacystin.	lactacystin	138-149	presenilin 2	Homo sapiens	57-60
9099900-3	1997	Using a gel shift assay we report here that nuclear extracts of steroidogenic granulosa cell lines, transformed by SV40 DNA and the Ha-ras oncogene show specific binding activity towards an Ad4 recognition sequence oligonucleotide.	Oligonucleotides	215-230	presenilin 2	Homo sapiens	190-193
9771752-4	1998	Using this PS2 domain in the yeast two-hybrid system, we have identified a neuronal protein that binds calcium and presenilin, which we call calsenilin.	Calcium	103-110	presenilin 2	Homo sapiens	11-14
8925918-6	1996	PS2 mRNA expression appeared correlated to a high degree with lipofuscin autofluorescence in a large subset of neurons.	Lipofuscin	62-72	presenilin 2	Homo sapiens	0-3
8837891-5	1995	The HEV penton base lacks the RGD motif, present in most human adenoviruses (Ad2, Ad3, Ad4, and Ad 12) suggesting that HEV may not use alpha v integrins to gain entry into host cells.	3,3-Bis(chloromethyl)oxetane	8-14	presenilin 2	Homo sapiens	87-90
7638622-3	1995	A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds.	Isoleucine	62-72	presenilin 2	Homo sapiens	20-24
7638622-3	1995	A point mutation in STM2, resulting in the substitution of an isoleucine for an asparagine (N141l), was identified in affected people from Volga German AD kindreds.	Asparagine	80-90	presenilin 2	Homo sapiens	20-24