PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33098824-8	2021	SiRNA transfection studies showed that PBA can be transported to NSC-34 cell lines through sodium-coupled MCT1.	Sodium	91-97	modifier of curly tail 1	Mus musculus	106-110
6773589-4	1980	The glycosaminoglycan fraction obtained from the AB-CBF1-MCT-1 mastocytoma cultured in vitro consisted predominantly of dermatan sulfate-like material.	Glycosaminoglycans	4-21	modifier of curly tail 1	Mus musculus	57-62
6773589-5	1980	On the other hand, the major components of the glycosaminoglycan fractions of the AB-CXBG-MCT-1 and AB-CXBI-MCT-1 and Furth tumors were observed to behave like heparin or heparan sulfate.	Glycosaminoglycans	47-64	modifier of curly tail 1	Mus musculus	90-95
6773589-5	1980	On the other hand, the major components of the glycosaminoglycan fractions of the AB-CXBG-MCT-1 and AB-CXBI-MCT-1 and Furth tumors were observed to behave like heparin or heparan sulfate.	Glycosaminoglycans	47-64	modifier of curly tail 1	Mus musculus	108-113
6773589-5	1980	On the other hand, the major components of the glycosaminoglycan fractions of the AB-CXBG-MCT-1 and AB-CXBI-MCT-1 and Furth tumors were observed to behave like heparin or heparan sulfate.	Heparin	160-167	modifier of curly tail 1	Mus musculus	108-113
33562048-11	2021	The MCT1 specificity of [18F]FACH uptake was confirmed by displacement studies in 4T1 cells.	fach	29-33	modifier of curly tail 1	Mus musculus	4-8
33540599-9	2021	Phenotypic characterization of mice focusing on metabolism, muscle and brain physiology found partial and transient memory retention defect as sole consequence of MCT1 inhibition by AZD3965.	AZD3965	182-189	modifier of curly tail 1	Mus musculus	163-167
32738449-8	2021	We identified Mct1 as a bona fide target of miR-342-3p in HCC.	mir-342-3p	44-54	modifier of curly tail 1	Mus musculus	14-18
32738449-9	2021	We show the tumor suppressor role of miR-342-3p is executed partly by modulating the lactate transport function of MCT1.	mir-342-3p	37-47	modifier of curly tail 1	Mus musculus	115-119
32738449-9	2021	We show the tumor suppressor role of miR-342-3p is executed partly by modulating the lactate transport function of MCT1.	Lactic Acid	85-92	modifier of curly tail 1	Mus musculus	115-119
32683248-2	2020	Niacin is transported into the cells by the monocarboxylate transporters: sodium-dependent monocarboxylate transporter (SMCT1 and SMCT2) and monocarboxylate transporter (MCT1).	Niacin	0-6	modifier of curly tail 1	Mus musculus	121-125
33268383-5	2021	We also observed that MCT1 mediates bidirectional and simultaneous inward and outward lactate fluxes which were required for efficient utilization of glucose by beige adipocytes activated by the canonical beta3-adrenergic signaling pathway.	Glucose	150-157	modifier of curly tail 1	Mus musculus	22-26
33268383-6	2021	Finally, we demonstrated that significant lactate import through MCT1 occurs even when glucose is not limiting, that feeds the oxidative metabolism of beige adipocytes.	Lactic Acid	42-49	modifier of curly tail 1	Mus musculus	65-69
33268383-6	2021	Finally, we demonstrated that significant lactate import through MCT1 occurs even when glucose is not limiting, that feeds the oxidative metabolism of beige adipocytes.	Glucose	87-94	modifier of curly tail 1	Mus musculus	65-69
33268383-5	2021	We also observed that MCT1 mediates bidirectional and simultaneous inward and outward lactate fluxes which were required for efficient utilization of glucose by beige adipocytes activated by the canonical beta3-adrenergic signaling pathway.	Lactic Acid	86-93	modifier of curly tail 1	Mus musculus	22-26
32683248-2	2020	Niacin is transported into the cells by the monocarboxylate transporters: sodium-dependent monocarboxylate transporter (SMCT1 and SMCT2) and monocarboxylate transporter (MCT1).	Sodium	74-80	modifier of curly tail 1	Mus musculus	121-125
32683248-11	2020	We report a rapid radioactivity accumulation in the kidney, heart, eyes and liver of intravenously administered [11C]niacin which is consistent with the known in vivo SMCTs and MCT1 transporter tissue expression.	[11c]niacin	112-123	modifier of curly tail 1	Mus musculus	177-181
32683248-13	2020	Pre-administration of AZD3965 selectively decreased [11C]niacin uptake in MCT1-expressing organs such as heart and retina.	AZD3965	22-29	modifier of curly tail 1	Mus musculus	74-78
32683248-13	2020	Pre-administration of AZD3965 selectively decreased [11C]niacin uptake in MCT1-expressing organs such as heart and retina.	Niacin	57-63	modifier of curly tail 1	Mus musculus	74-78
32146873-7	2020	Glycogen catabolism was also observed in cachexic livers along with decreased pyruvate dehydrogenase protein X component (Pdhx), increased lactate dehydrogenase A chain (Ldha), and increased lactate transporter Mct1.	Glycogen	0-8	modifier of curly tail 1	Mus musculus	211-215
32423056-8	2020	In vivo and in vitro studies revealed high uptake of the new radiotracer in kidney and other peripheral MCT-expressing organs together with significant reduction by using specific MCT1 inhibitor alpha-cyano-4-hydroxycinnamic acid.	alpha-cyano-4-hydroxycinnamate	195-229	modifier of curly tail 1	Mus musculus	180-184
31853067-6	2020	In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species.	Oxygen	116-122	modifier of curly tail 1	Mus musculus	27-31
32362817-1	2020	The monocarboxylate transporters (MCTs) MCT1, MCT2, and MCT4 are essential components of the astrocyte-neuron lactate shuttle (ANLS), which is a fundamental element of brain energetics.	Lactic Acid	110-117	modifier of curly tail 1	Mus musculus	40-44
32362817-7	2020	We suggest that redistribution of hippocampal MCT1 and MCT4, but not MCT2 up-regulation, may be related to learning and memory deficits induced by long-term ketamine administration.	Ketamine	157-165	modifier of curly tail 1	Mus musculus	46-50
31853067-6	2020	In addition, inhibition of MCT1 suppressed the oxidative pentose phosphate pathway and increased levels of reactive oxygen species.	Pentosephosphates	57-74	modifier of curly tail 1	Mus musculus	27-31
31160535-7	2019	Suppression was MCT-1 dependent and reproducible with sodium lactate or formic acid.	Sodium Lactate	54-68	modifier of curly tail 1	Mus musculus	16-21
31073907-4	2019	Among the family of MCTs, MCT1 is at least partly responsible for lactate uptake by the germ cells.	Lactic Acid	66-73	modifier of curly tail 1	Mus musculus	26-30
31073907-11	2019	MCT1 cKO animals presented also hormonal dysregulation, with a decrease in serum 17beta-estradiol levels.	Estradiol	81-97	modifier of curly tail 1	Mus musculus	0-4
31160535-7	2019	Suppression was MCT-1 dependent and reproducible with sodium lactate or formic acid.	formic acid	72-83	modifier of curly tail 1	Mus musculus	16-21
30561869-6	2019	We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat-treated cells.	Lactic Acid	78-85	modifier of curly tail 1	Mus musculus	221-225
31081109-10	2019	In addition, Dex administration further increased the expression of MCT1, whereas decreased the expressions of cytochrome c, cleaved caspase-9 and -3 in contrast to the I/R group.	Dexmedetomidine	13-16	modifier of curly tail 1	Mus musculus	68-72
31081109-11	2019	CONCLUSIONS: Dex elevated the expression of mitochondrial MCT1 and inhibited oxidative stress and the activation of mitochondria-dependent apoptosis in mice.	Dexmedetomidine	13-16	modifier of curly tail 1	Mus musculus	58-62
30391286-0	2019	Cytotoxic action of acetate on tumor cells of thymic origin: Role of MCT-1, pH homeostasis and altered cell survival regulation.	Acetates	20-27	modifier of curly tail 1	Mus musculus	69-74
30391286-9	2019	Acetate treatment of tumor cells inhibited tumor cell survival accompanied by induction of apoptotic cell death, associated with modulated expression of cell survival regulatory HIF1alpha, ROS, p53, Caspase 3, Bax and HSP70 along with the elevated level of cytosolic cytochrome c. Acetate treatment also modulated the expression of pH regulators MCT-1 and V-ATPase accompanied by altered pH homeostasis.	Acetates	0-7	modifier of curly tail 1	Mus musculus	346-351
30391286-11	2019	Further, pre-exposure of tumor cells to alpha-CHC (alpha-cyano-4-hydroxycinnamate), an inhibitor of MCT-1, partially abrogated the cytotoxic action of acetate.	alpha-cyano-4-hydroxycinnamate	51-81	modifier of curly tail 1	Mus musculus	100-105
30391286-11	2019	Further, pre-exposure of tumor cells to alpha-CHC (alpha-cyano-4-hydroxycinnamate), an inhibitor of MCT-1, partially abrogated the cytotoxic action of acetate.	Acetates	151-158	modifier of curly tail 1	Mus musculus	100-105
30561869-6	2019	We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat-treated cells.	Lactic Acid	150-157	modifier of curly tail 1	Mus musculus	221-225
30561869-6	2019	We found that the most likely explanation for our finding that hyperpolarized lactate is reduced in treated cells is a 30% reduction in intracellular lactate levels that occurs as a result of increased expression of both MCT1 and MCT4 in vorinostat-treated cells.	Vorinostat	238-248	modifier of curly tail 1	Mus musculus	221-225
30561869-7	2019	In vivo 13 C MRSI studies of orthotopic tumors in mice also showed a significant 52% decrease in hyperpolarized [1-13 C]Lac/Pyr when comparing vorinostat-treated U87 GBM tumors with controls, and, as in the cell studies, this metabolic finding was associated with increased MCT1 and MCT4 expression in HDAC-inhibited tumors.	Vorinostat	143-153	modifier of curly tail 1	Mus musculus	274-278
30617815-8	2019	AR-C155858 uptake, but not AZD3965 uptake, was significantly inhibited by alpha-cyano-4-hydroxycinnamic acid, a known nonspecific inhibitor of MCTs 1, 2, and 4.	alpha-cyano-4-hydroxycinnamate	74-108	modifier of curly tail 1	Mus musculus	143-159
29232177-12	2018	Metformin reduced MCT1 staining by 28% ( P = .05) and increased carcinoma cell apoptosis 1.8-fold as marked by TUNEL assay ( P = .005).	Metformin	0-9	modifier of curly tail 1	Mus musculus	18-22
25470525-10	2015	The soleus, liver and heart were the main tissues that showed improved the MCT1 mRNA expression, indicating its important role in controlling MLSS concentration in mice.	mlss	142-146	modifier of curly tail 1	Mus musculus	75-79
27559047-5	2016	Using inhibitors for monocarboxylate transporters (MCT) or replacing LA with sodium lactate revealed that LA effects are MCT-1- and pH-dependent.	Sodium Lactate	77-91	modifier of curly tail 1	Mus musculus	121-126
26178372-7	2015	Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation.	Lactic Acid	114-121	modifier of curly tail 1	Mus musculus	131-135
26178372-7	2015	Besides, lactate exporter monocarboxylate transporter 4 (Mct4) is induced in newly formed decidual cells, whereas lactate importer Mct1 and proliferation marker Ki-67 are complementarily located in the surrounding undifferentiated cells, which are supposed to consume lactate for proliferation.	Lactic Acid	114-121	modifier of curly tail 1	Mus musculus	131-135
26203664-4	2015	In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment.	Lactic Acid	164-171	modifier of curly tail 1	Mus musculus	47-51
29092796-7	2017	It is proposed that reduced hepatic lactate metabolism is responsible for the protection against hepatic steatosis in MCT1 haploinsufficient mice via a constitutive activation of AMPK and repression of several major elements involved in hepatic lipid metabolism.	Lactic Acid	36-43	modifier of curly tail 1	Mus musculus	118-122
29026134-7	2017	Adipocyte differentiation was accompanied by increased plasma membrane lactate flux capacity, which was reduced by MCT inhibition and by MCT1 knockdown.	Lactic Acid	71-78	modifier of curly tail 1	Mus musculus	137-141
29026134-9	2017	We suggest that upregulation of MCT1- and MCT4-mediated lactate flux capacity and NBCe1-mediated HCO3-/pH homeostasis are important for the physiological function of mature adipocytes.	Lactic Acid	56-63	modifier of curly tail 1	Mus musculus	32-36
28955302-12	2017	Oral administration of telmisartan (1 mg/kg, for 7 days, n = 10 per group) ameliorated cortical or hippocampal mRNA for Glut-1/3, MCT-1/2 and PDH in CCI mice.	Telmisartan	23-34	modifier of curly tail 1	Mus musculus	130-135
28433571-7	2017	Pretreatment with MCT-1 inhibitor alpha-cyano-4-hydroxycinnamate and siRNA gene silencing of HK 2 implicated the role of MCT-1 and HK 2 in 3-BP cytotoxicity.	alpha-cyano-4-hydroxycinnamate	34-64	modifier of curly tail 1	Mus musculus	18-23
27733550-8	2016	Day 7 spleen transcripts from minocycline-treated EAE mice had a significantly lower MMP-9/TIMP-1 ratio, and significantly lower MCT-1 and CD98 levels, factors associated with EMMPRIN function.	Minocycline	30-41	modifier of curly tail 1	Mus musculus	129-134
25986445-6	2015	HOCPCA inhibited the uptake of the endogenous MCT substrate l-[(14)C]lactate, and [(3)H]HOCPCA was shown to act as substrate for MCT1 and 2 (Km values in the low- to mid-millimolar range).	)c]lactate	66-76	modifier of curly tail 1	Mus musculus	129-139
25986445-6	2015	HOCPCA inhibited the uptake of the endogenous MCT substrate l-[(14)C]lactate, and [(3)H]HOCPCA was shown to act as substrate for MCT1 and 2 (Km values in the low- to mid-millimolar range).	3-hydroxycyclopent-1-enecarboxylic acid	88-94	modifier of curly tail 1	Mus musculus	129-139
26059436-1	2015	Lactic acid generated by highly glycolytic tumours is exported by the MonoCarboxylate Transporters, MCT1 and MCT4, to maintain pHi and energy homeostasis.	Lactic Acid	0-11	modifier of curly tail 1	Mus musculus	100-104
24081524-2	2014	The aim of this study was to investigate the effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) induced activation of AMP-activated protein kinase (AMPK) on MCT1, MCT4, and GLUT4 in denervated muscle.	acadesine	55-109	modifier of curly tail 1	Mus musculus	179-183
24573205-1	2014	The monocarboxylate transporter (MCT)-1 plays an important role in the transfer of monocarboxylate metabolites such as lactate, ketone bodies, and acetic acid.	Lactic Acid	119-126	modifier of curly tail 1	Mus musculus	4-39
24573205-1	2014	The monocarboxylate transporter (MCT)-1 plays an important role in the transfer of monocarboxylate metabolites such as lactate, ketone bodies, and acetic acid.	Ketones	128-134	modifier of curly tail 1	Mus musculus	4-39
24573205-1	2014	The monocarboxylate transporter (MCT)-1 plays an important role in the transfer of monocarboxylate metabolites such as lactate, ketone bodies, and acetic acid.	Acetic Acid	147-158	modifier of curly tail 1	Mus musculus	4-39
24573205-3	2014	An intense MCT1 immunoreactivity was found in the reticular cells forming a cellular network together with sinus-lining cells in the medullary sinuses and in cells covering the inside of subcapsular sinuses.Electron-microscopically, MCT1 was localized along the plasma membrane of the reticular cells.The medullary reticular cells vigorously ingested carboxylate-modified latex particles, but any reticular cells within the cortical lymphoid follicles and medullary cords neither expressed MCT1 nor incorporated latex particles.	carboxylate	351-362	modifier of curly tail 1	Mus musculus	11-15
24573205-5	2014	The selective localization of MCT1 and LYVE-1 suggests a high level of activity for lymphoid reticular cells in the uptake of carboxylate-modified and hyaluronate waste substances circulating in the body.	carboxylate	126-137	modifier of curly tail 1	Mus musculus	30-34
24573205-5	2014	The selective localization of MCT1 and LYVE-1 suggests a high level of activity for lymphoid reticular cells in the uptake of carboxylate-modified and hyaluronate waste substances circulating in the body.	hyaluronate	151-162	modifier of curly tail 1	Mus musculus	30-34
24081524-2	2014	The aim of this study was to investigate the effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) induced activation of AMP-activated protein kinase (AMPK) on MCT1, MCT4, and GLUT4 in denervated muscle.	acadesine	111-116	modifier of curly tail 1	Mus musculus	179-183
24376811-6	2013	Phloretin (MCT1 inhibitor) accentuated the volume loss compared to both NaLac controls, supporting a role for MCT1 in the RVI response in the presence of elevated [lactate-].	Phloretin	0-9	modifier of curly tail 1	Mus musculus	11-15
24376811-10	2013	In conclusion, RVI in skeletal muscle exposed to raised tonicity and [lactate-] is facilitated by inward flux of solute by NKCC- and MCT1-dependent mechanisms.	Lactic Acid	70-77	modifier of curly tail 1	Mus musculus	133-137
24367518-1	2013	The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues.	Fatty Acids, Volatile	68-91	modifier of curly tail 1	Mus musculus	35-39
24367518-1	2013	The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues.	Ketones	93-99	modifier of curly tail 1	Mus musculus	35-39
24367518-1	2013	The monocarboxylate transporter 1 (MCT1 or SLC16A1) is a carrier of short-chain fatty acids, ketone bodies, and lactate in several tissues.	Lactic Acid	112-119	modifier of curly tail 1	Mus musculus	35-39
23898516-1	2013	OBJECTIVE: To investigate the antitumor effect of the combination of metformin with alpha-cyano-4-hydroxycinnamic acid (CHC, a MCT1 inhibitor) in the treatment of Lewis lung cancer.	alpha-cyano-4-hydroxycinnamate	84-118	modifier of curly tail 1	Mus musculus	127-131
24303150-15	2013	MCT1 but not MCT4 expression is altered at the onset of skeletal muscle regeneration possibly in an attempt to regulate lactate uptake and use by skeletal muscle cells.	Lactic Acid	120-127	modifier of curly tail 1	Mus musculus	0-4
23014881-6	2012	In contrast, SLC16A1 (MCT1), which is important in the uptake of monocarboxylates, and SLCO4C1 (OATP4C1) were expressed in HK-2 cells.	monocarboxylates	65-81	modifier of curly tail 1	Mus musculus	22-26
22451434-4	2012	The augmentation of lactate transport is independent of the enzyme"s catalytic activity, but requires direct binding of CAII to the C-terminal of the monocarboxylate transporter MCT1, one of the major lactate/proton cotransporters in astrocytes and most tissues.	Lactic Acid	20-27	modifier of curly tail 1	Mus musculus	178-182
22705712-4	2012	DCA treatment also altered expression of HIF1-alpha and pH regulators: VATPase and MCT1 and production of cytokines: IL-10, IL-6 and IFN-gamma.	Dichloroacetic Acid	0-3	modifier of curly tail 1	Mus musculus	83-87
22451434-5	2012	By employing its intramolecular proton shuttle, CAII, bound to MCT1, can act as a "proton collecting antenna" for the transporter, suppressing the formation of proton microdomains at the transporter-pore and thereby enhancing lactate flux.	Lactic Acid	226-233	modifier of curly tail 1	Mus musculus	63-67
21792931-6	2012	We propose that basigin interacts with MCT1 and MCT2 to locate them properly in the membrane of spermatogenic cells and that this may enable sperm to utilize lactate as an energy substrate contributing to cell survival.	Lactic Acid	158-165	modifier of curly tail 1	Mus musculus	39-43
21141497-8	2010	Moreover, MCT1 and MCT2 upregulated accompanied with the increase of lactate, MCT2 mRNA enhanced in brazilein 5 mg x kg(-1) group (P < 0.05) while both the two factors increased in brazilein 10 mg x kg(-1) group (P < 0.01).	Lactic Acid	69-76	modifier of curly tail 1	Mus musculus	10-14
22357971-3	2012	In a 25 mM glucose culture medium, BHBA increased intracellular calcium concentrations and the expression of monocarboxylate transporter 1 (MCT1 (SLC16A1)).	Glucose	11-18	modifier of curly tail 1	Mus musculus	140-144
22357971-3	2012	In a 25 mM glucose culture medium, BHBA increased intracellular calcium concentrations and the expression of monocarboxylate transporter 1 (MCT1 (SLC16A1)).	3-Hydroxybutyric Acid	35-39	modifier of curly tail 1	Mus musculus	140-144
21704401-2	2011	However, recently it was suggested that lactate produced in hypoxic tumor areas may be taken up by the monocarboxylate transporter MCT1 and oxidized in well-oxygenated tumor parts.	Lactic Acid	40-47	modifier of curly tail 1	Mus musculus	131-135
21704401-3	2011	Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.	Lactic Acid	45-52	modifier of curly tail 1	Mus musculus	73-77
21704401-3	2011	Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.	alpha-cyano-hydroxycinnamate	88-116	modifier of curly tail 1	Mus musculus	73-77
21704401-3	2011	Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.	alpha-cyano-4-hydroxycinnamate	118-121	modifier of curly tail 1	Mus musculus	73-77
21704401-3	2011	Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.	Lactic Acid	184-191	modifier of curly tail 1	Mus musculus	73-77
21704401-3	2011	Furthermore, it was shown that inhibition of lactate oxidation using the MCT1 inhibitor alpha-cyano-hydroxycinnamate (CHC) can radio-sensitize tumors possibly by forcing a switch from lactate oxidization to glycolysis in oxygenated cells, which in turn improves tumor oxygenation and indirectly kills radio-resistant hypoxic tumor cells from glucose starvation.	Glucose	342-349	modifier of curly tail 1	Mus musculus	73-77
21141497-8	2010	Moreover, MCT1 and MCT2 upregulated accompanied with the increase of lactate, MCT2 mRNA enhanced in brazilein 5 mg x kg(-1) group (P < 0.05) while both the two factors increased in brazilein 10 mg x kg(-1) group (P < 0.01).	brazilein	100-109	modifier of curly tail 1	Mus musculus	10-14
21141497-8	2010	Moreover, MCT1 and MCT2 upregulated accompanied with the increase of lactate, MCT2 mRNA enhanced in brazilein 5 mg x kg(-1) group (P < 0.05) while both the two factors increased in brazilein 10 mg x kg(-1) group (P < 0.01).	brazilein	184-193	modifier of curly tail 1	Mus musculus	10-14
22357971-6	2012	This increase was prevented by preincubation with the AMPK inhibitor Compound C. The inhibition of MCT1 activity by p-hydroxymercuribenzoate suppressed BHBA-stimulated AMPK phosphorylation but did not prevent BHBA-induced Agrp mRNA expression.	4-hydroxymercuribenzoate	116-140	modifier of curly tail 1	Mus musculus	99-103
22357971-6	2012	This increase was prevented by preincubation with the AMPK inhibitor Compound C. The inhibition of MCT1 activity by p-hydroxymercuribenzoate suppressed BHBA-stimulated AMPK phosphorylation but did not prevent BHBA-induced Agrp mRNA expression.	3-Hydroxybutyric Acid	152-156	modifier of curly tail 1	Mus musculus	99-103
22357971-6	2012	This increase was prevented by preincubation with the AMPK inhibitor Compound C. The inhibition of MCT1 activity by p-hydroxymercuribenzoate suppressed BHBA-stimulated AMPK phosphorylation but did not prevent BHBA-induced Agrp mRNA expression.	3-Hydroxybutyric Acid	209-213	modifier of curly tail 1	Mus musculus	99-103
19048272-7	2009	Since the secretions from these glands contain fat as a major product, the cellular localization of MCT1 suggests the involvement of the transporter in the uptake of lactate, acetate, and other monocarboxylates for production of medium- and long-chain fatty acids.	Lactic Acid	166-173	modifier of curly tail 1	Mus musculus	100-104
19729852-6	2009	These results, together with the intense expression of CD147 (a functional partner of MCTs) and acetyl-CoA carboxylase-2 (a component of fatty acid oxidation) in perinatal periods, suggest the involvement of MCT1 in the uptake of monocarboxylates from the circulation for thermogenesis rather than lipogenesis.	Fatty Acids	137-147	modifier of curly tail 1	Mus musculus	208-212
19729852-6	2009	These results, together with the intense expression of CD147 (a functional partner of MCTs) and acetyl-CoA carboxylase-2 (a component of fatty acid oxidation) in perinatal periods, suggest the involvement of MCT1 in the uptake of monocarboxylates from the circulation for thermogenesis rather than lipogenesis.	monocarboxylates	230-246	modifier of curly tail 1	Mus musculus	208-212
21099300-1	2010	We have previously identified two genes, encoding lactate dehydrogenase (Ldha) and the monocarboxylate carrier, MCT1 (Slc16a1) whose expression is remarkably low in pancreatic beta-cells and islets.	monocarboxylate	87-102	modifier of curly tail 1	Mus musculus	112-116
19604494-5	2009	Immortalized cardiomyocytes (HL-1 cells) were injured with hydrogen peroxide, and cell death in the presence or absence of the competitive inhibitor of MCT1, d-lactate, was evaluated by Trypan blue exclusion.	Lactic Acid	158-167	modifier of curly tail 1	Mus musculus	152-156
19604494-14	2009	Increased MCT1 expression after ischemia and reperfusion is likely to restore cardiac pH through lactate export.	Lactic Acid	97-104	modifier of curly tail 1	Mus musculus	10-14
19048272-7	2009	Since the secretions from these glands contain fat as a major product, the cellular localization of MCT1 suggests the involvement of the transporter in the uptake of lactate, acetate, and other monocarboxylates for production of medium- and long-chain fatty acids.	Acetates	175-182	modifier of curly tail 1	Mus musculus	100-104
19048272-7	2009	Since the secretions from these glands contain fat as a major product, the cellular localization of MCT1 suggests the involvement of the transporter in the uptake of lactate, acetate, and other monocarboxylates for production of medium- and long-chain fatty acids.	and long-chain fatty acids	237-263	modifier of curly tail 1	Mus musculus	100-104
18385447-6	2008	In mouse embryos, continued expression of Slc16a1 (MCT1) requires glucose supply.	Glucose	66-73	modifier of curly tail 1	Mus musculus	51-55
19129673-2	2008	However, under conditions of a reduced utilization of glucose, the brain is dependent upon monocarboxylates such as ketone bodies and lactate, being accompanied by an elevated expression of a monocarboxylate transporter (MCT1) in the blood-brain barrier.	Glucose	54-61	modifier of curly tail 1	Mus musculus	221-225
19129673-2	2008	However, under conditions of a reduced utilization of glucose, the brain is dependent upon monocarboxylates such as ketone bodies and lactate, being accompanied by an elevated expression of a monocarboxylate transporter (MCT1) in the blood-brain barrier.	Ketones	116-122	modifier of curly tail 1	Mus musculus	221-225
19129673-8	2008	These findings suggest that peripheral nerves depend on monocarboxylates as a major energy source and that MCT1 in the perineurium is responsible for the supply of monocarboxylates to nerve fibers and Schwann cells.	monocarboxylates	164-180	modifier of curly tail 1	Mus musculus	107-111
18379211-5	2008	Subsequently, the presence of a mitochondrial lactate oxidation complex (composed of mMCT1, CD147 (basigin), mLDH, and cytochrome oxidase (COX)) was discovered, which lends support to the presence of the ILS.	Lactic Acid	46-53	modifier of curly tail 1	Mus musculus	85-90
11879800-11	2002	Many substrates and inhibitors of MCT1 and organic anion transporters reduced Al citrate uptake into b.End5 cells.	aluminum citrate	78-88	modifier of curly tail 1	Mus musculus	34-38
17998878-6	2007	The specific MCT1 inhibitor AR-C117977 has potent immunosuppressive properties in vivo effectively preventing acute but not chronic allograft rejection in the mouse.	c117977	31-38	modifier of curly tail 1	Mus musculus	13-17
16514190-0	2006	Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development.	Glucose	0-7	modifier of curly tail 1	Mus musculus	16-53
16514190-3	2006	In the case of lactate and pyruvate, this occurs via H+-monocarboxylate cotransporter (MCT) proteins.	Lactic Acid	15-22	modifier of curly tail 1	Mus musculus	56-86
16514190-3	2006	In the case of lactate and pyruvate, this occurs via H+-monocarboxylate cotransporter (MCT) proteins.	Pyruvic Acid	27-35	modifier of curly tail 1	Mus musculus	56-86
16514190-6	2006	For embryos derived in vivo and those cultured with glucose, MCT1 mRNA was present throughout preimplantation development, protein immunoreactivity appearing diffuse throughout the cytoplasm with brightest intensity in the outer cortical region of blastomeres.	Glucose	52-59	modifier of curly tail 1	Mus musculus	61-65
16514190-10	2006	The differential expression of MCT1 in the presence or absence of glucose demonstrates that it is important in the critical regulation of pH and monocarboxylate transport during preimplantation development, and implies a role for glucose in the control of MCT1, but not MCT3, expression.	Glucose	66-73	modifier of curly tail 1	Mus musculus	31-35
16514190-10	2006	The differential expression of MCT1 in the presence or absence of glucose demonstrates that it is important in the critical regulation of pH and monocarboxylate transport during preimplantation development, and implies a role for glucose in the control of MCT1, but not MCT3, expression.	monocarboxylate	145-160	modifier of curly tail 1	Mus musculus	31-35
16514190-10	2006	The differential expression of MCT1 in the presence or absence of glucose demonstrates that it is important in the critical regulation of pH and monocarboxylate transport during preimplantation development, and implies a role for glucose in the control of MCT1, but not MCT3, expression.	Glucose	230-237	modifier of curly tail 1	Mus musculus	31-35
15121743-1	2004	We sought to test the hypothesis that monocarboxylate transporter isoform 1 (MCT1) is the inner mitochondrial membrane lactate/pyruvate transporter, and, as such, contributes to functioning of the intracellular lactate shuttle.	Lactic Acid	119-126	modifier of curly tail 1	Mus musculus	77-81
15121743-1	2004	We sought to test the hypothesis that monocarboxylate transporter isoform 1 (MCT1) is the inner mitochondrial membrane lactate/pyruvate transporter, and, as such, contributes to functioning of the intracellular lactate shuttle.	Lactic Acid	211-218	modifier of curly tail 1	Mus musculus	77-81
11098125-9	2000	In conclusion, these observations are consistent with the possibility that lactate, produced and released by astrocytes (via MCT1), could be taken up (via MCT2) and used by neurons as an energy substrate.	Lactic Acid	75-82	modifier of curly tail 1	Mus musculus	125-129
33762304-6	2021	We found that MYCN-amplified neuroblastoma is hypersensitive to the combination of an inhibitor of the lactate transporter MCT1, AZD3965, and complex I of the mitochondrion, phenformin.	Phenformin	174-184	modifier of curly tail 1	Mus musculus	123-127
8603082-6	1996	One difference between the mouse and Chinese hamster MCT1 is the absence of a predicted external consensus sequence for N-linked glycosylation in the mouse sequence.	Nitrogen	120-121	modifier of curly tail 1	Mus musculus	53-57
10398873-6	1999	The inhibitor of MCT1, p-chloromercuribenzoic acid, completely abolished the effect of extracellular l-lactate on pHi suggesting that MCT1, and not MCT2, plays a functional role in pHi regulation in mouse conceptuses, while the role of MCT3 remains unclear.	p-Chloromercuribenzoic Acid	23-50	modifier of curly tail 1	Mus musculus	17-21
10398873-6	1999	The inhibitor of MCT1, p-chloromercuribenzoic acid, completely abolished the effect of extracellular l-lactate on pHi suggesting that MCT1, and not MCT2, plays a functional role in pHi regulation in mouse conceptuses, while the role of MCT3 remains unclear.	p-Chloromercuribenzoic Acid	23-50	modifier of curly tail 1	Mus musculus	134-138
10398873-6	1999	The inhibitor of MCT1, p-chloromercuribenzoic acid, completely abolished the effect of extracellular l-lactate on pHi suggesting that MCT1, and not MCT2, plays a functional role in pHi regulation in mouse conceptuses, while the role of MCT3 remains unclear.	L-lactate	101-110	modifier of curly tail 1	Mus musculus	17-21
10398873-6	1999	The inhibitor of MCT1, p-chloromercuribenzoic acid, completely abolished the effect of extracellular l-lactate on pHi suggesting that MCT1, and not MCT2, plays a functional role in pHi regulation in mouse conceptuses, while the role of MCT3 remains unclear.	L-lactate	101-110	modifier of curly tail 1	Mus musculus	134-138
33762304-8	2021	Low MCT4 combines with high expression of the MCT2 and MCT1 chaperone CD147 in MYCN-amplified neuroblastoma, altogether conferring sensitivity to the AZD3965 and phenformin combination.	AZD3965	150-157	modifier of curly tail 1	Mus musculus	55-59
34769321-12	2021	A feasible mechanism would involve that melatonin up-regulated the Faecalibacterium population and production of its metabolite butyrate and MCT1 expression and inhibited HDAC3 in the colon, which would allow p-GSK-3beta/beta-catenin/HIF-1alpha activation and NF-kappaB/NLRP3 suppression to up-regulate Card9 expression and suppress inflammation response.	Melatonin	40-49	modifier of curly tail 1	Mus musculus	141-145
34603087-12	2021	In addition, hippocampal monocarboxylate transporters (MCT)1, MCT2, and brain-derived neurotrophic factor (BDNF) mRNA expression, except MCT4, also increased after high-intensity exercise, which was abolished by UK5099 administration.	2-cyano-3-(1-phenylindol-3-yl)acrylate	212-218	modifier of curly tail 1	Mus musculus	13-60
34676828-4	2021	Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle.	BSG	59-62	modifier of curly tail 1	Mus musculus	15-19
34676828-4	2021	Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle.	Lactic Acid	143-150	modifier of curly tail 1	Mus musculus	15-19
34676828-4	2021	Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle.	Pyruvic Acid	155-163	modifier of curly tail 1	Mus musculus	15-19
34676828-4	2021	Abolishment of MCT1 in the plasma membrane was achieved by Bsg depletion, which led to gluconeogenesis impairment via preventing the influx of lactate and pyruvate into the cell, consequently suppressing the TCA cycle.	Tricarboxylic Acids	208-211	modifier of curly tail 1	Mus musculus	15-19
34603087-13	2021	Further, injection of 1,4-dideoxy-1,4-imino-D-arabinitol (glycogen phosphorylase inhibitor) into the hippocampus before high-intensity exercise suppressed glycogen consumption during exercise, but hippocampal lactate, PGC-1alpha, MCT1, and MCT2 mRNA concentrations were not altered after exercise.	1,4-dideoxy-1,4-iminoarabinitol	22-56	modifier of curly tail 1	Mus musculus	230-234
35199915-8	2022	In addition, nimbolide administration impaired glycolysis and pH homeostasis with concomitant inhibition of crucial glycolysis and pH regulatory molecules such as GLUT3, LDHA, MCT1, and V-ATPase, CAIX and NHE1, respectively.	nimbolide	13-22	modifier of curly tail 1	Mus musculus	176-180
34298681-9	2021	Furthermore, MCT1 downregulation increased the sensitivity to temozolomide in vitro and in vivo, resulting in significantly longer mice survival.	Temozolomide	62-74	modifier of curly tail 1	Mus musculus	13-17
34077729-3	2021	We report that resistance to glycolysis inhibitor 3-bromopyruvate (3-BrPA) arises from DNA methylation in treated cancer cells and subsequent silencing of the monocarboxylate transporter MCT1.	bromopyruvate	50-65	modifier of curly tail 1	Mus musculus	187-191
34077729-3	2021	We report that resistance to glycolysis inhibitor 3-bromopyruvate (3-BrPA) arises from DNA methylation in treated cancer cells and subsequent silencing of the monocarboxylate transporter MCT1.	bromopyruvate	67-73	modifier of curly tail 1	Mus musculus	187-191
34129243-7	2021	We found increased high-affinity glucose transporter GLUT1 in tumours, suggesting active glucose uptake, tumour MCT1 detection and decreased intratumour (L-lactate)/(pyruvate), implying increased lactate efflux and/or intratumour lactate oxidation.	Glucose	33-40	modifier of curly tail 1	Mus musculus	112-116
35002512-6	2022	Moreover, blockade of LA intake with AZD3965 (MCT-1 inhibitor) could rescue pregnancy in an abortion-prone mouse model, suggesting a potential therapeutic target in RPL.	AZD3965	37-44	modifier of curly tail 1	Mus musculus	46-51
35561261-0	2022	Bisphenol S favors hepatic steatosis development via an upregulation of liver MCT1 expression and an impairment of the mitochondrial respiratory system.	bis(4-hydroxyphenyl)sulfone	0-9	modifier of curly tail 1	Mus musculus	78-82
35561261-6	2022	Moreover, data show that BPS increases hepatic MCT1 (a key energetic fuel transporter) mRNA expression accompanied by hepatic steatosis initiation and lipid accumulation, while disrupting mitochondrial function and oxidative stress parameters.	bis(4-hydroxyphenyl)sulfone	25-28	modifier of curly tail 1	Mus musculus	47-51