PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23911207-1	2013	N-(3-oxododecanoyl)-l-homoserine lactone (3OC(12)-HSL) is a quorum-sensing molecule produced by gram-negative microbial pathogens such as Pseudomonas aeruginosa (PAO1).	N-(3-oxododecanoyl)homoserine lactone	0-40	spermine oxidase	Mus musculus	162-166
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Flavin-Adenine Dinucleotide	28-31	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Flavin-Adenine Dinucleotide	22-25	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Polyamines	56-66	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Spermine	101-109	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Hydrogen Peroxide	121-125	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	Spermidine	127-137	spermine oxidase	Mus musculus	0-16
23840306-1	2013	Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce H2O2, spermidine, and 3-aminopropanal.	3-aminopropionaldehyde	143-158	spermine oxidase	Mus musculus	0-16
23840306-2	2013	Spermine oxidase is highly expressed in the mouse brain and plays a key role in regulating the levels of spermine, which is involved in protein synthesis, cell division and cell growth.	Spermine	105-113	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Hydrogen Peroxide	148-156	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Hydrogen Peroxide	148-156	spermine oxidase	Mus musculus	18-21
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Flavin-Adenine Dinucleotide	28-31	spermine oxidase	Mus musculus	18-21
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Spermidine	158-168	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Spermidine	158-168	spermine oxidase	Mus musculus	18-21
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Polyamines	74-84	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	3-aminopropionaldehyde	178-193	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	3-aminopropionaldehyde	178-193	spermine oxidase	Mus musculus	18-21
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Polyamines	74-84	spermine oxidase	Mus musculus	18-21
18852063-3	2009	SMO transcript accumulation and enzymatic activity increases during C2C12 cell differentiation and correlates with the decrease of spermine content.	Spermine	131-139	spermine oxidase	Mus musculus	0-3
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Polyamines	86-88	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Polyamines	86-88	spermine oxidase	Mus musculus	18-21
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Spermine	125-133	spermine oxidase	Mus musculus	0-16
18852063-1	2009	Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal.	Spermine	125-133	spermine oxidase	Mus musculus	18-21
14764092-2	2004	Spermine oxidase (SMO) is a flavoenzyme involved in polyamine homeostasis in animal cells.	Polyamines	52-61	spermine oxidase	Mus musculus	0-16
18381427-7	2008	Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.	lysylglutamylarginine	68-71	spermine oxidase	Mus musculus	214-230
18381427-7	2008	Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.	lysylglutamylarginine	68-71	spermine oxidase	Mus musculus	232-235
18381427-7	2008	Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.	Polyamines	124-133	spermine oxidase	Mus musculus	214-230
18381427-7	2008	Both reactive oxygen species generation and apoptotic cell death of Ker/ODC may, at least in part, be due to induction of a polyamine catabolic pathway that generates both H(2)O(2) and cytotoxic aldehydes, because spermine oxidase (SMO) levels are induced in Ker/ODC.	Polyamines	124-133	spermine oxidase	Mus musculus	232-235
18381427-8	2008	In addition, treatment with MDL 72,527, an inhibitor of SMO, blocks the production of H(2)O(2) and increases the survival of Ker/ODC.	Hydrogen Peroxide	86-94	spermine oxidase	Mus musculus	56-59
15247269-0	2004	Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.	Hydrogen Peroxide	87-104	spermine oxidase	Mus musculus	13-32
15247269-8	2004	Inhibition of PAO1 also significantly reduced H(2)O(2) generation, mitochondrial membrane depolarization, cytochrome c release, and caspase-3 activation.	Hydrogen Peroxide	46-54	spermine oxidase	Mus musculus	14-18
15247269-11	2004	These studies demonstrate a new mechanism for pathogen-induced oxidative stress in macrophages in which activation of PAO1 leads to H(2)O(2) release and apoptosis by a mitochondrial-dependent cell death pathway, contributing to deficiencies in host defense in diseases such as H. pylori infection.	Hydrogen Peroxide	132-140	spermine oxidase	Mus musculus	118-122
15313165-0	2004	Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine.	SCHEMBL7593864	77-119	spermine oxidase	Mus musculus	6-22
15313165-1	2004	Spermine oxidase (SMO) is a recently described flavoenzyme belonging to the class of polyamine oxidases (PAOs) and participating in the polyamine metabolism in animal cells.	Polyamines	85-94	spermine oxidase	Mus musculus	0-16
15313165-1	2004	Spermine oxidase (SMO) is a recently described flavoenzyme belonging to the class of polyamine oxidases (PAOs) and participating in the polyamine metabolism in animal cells.	Polyamines	85-94	spermine oxidase	Mus musculus	18-21
14764092-2	2004	Spermine oxidase (SMO) is a flavoenzyme involved in polyamine homeostasis in animal cells.	Polyamines	52-61	spermine oxidase	Mus musculus	18-21
7532082-14	1994	The effect of sper mine on nitrite production can be prevented by isoniazid, hydrazine or hydroxylamine, inhibitors of spermine oxidase, as well as by phenylhydrazine, an aldehyde inhibitor.	Nitrites	27-34	spermine oxidase	Mus musculus	119-135
12458219-2	2003	Recently, a novel enzyme belonging to this class of enzymes has been characterized for its capability to oxidize preferentially spermine and designated as spermine oxidase.	Spermine	128-136	spermine oxidase	Mus musculus	155-171
34572487-2	2021	A transgenic mouse overexpressing spermine oxidase (SMOX, which specifically oxidizes spermine) in the neocortex neurons (Dach-SMOX mouse) was proved to be a model of increased susceptibility to excitotoxic injury.	Spermine	86-94	spermine oxidase	Mus musculus	34-50
34767785-2	2022	We have shown that spermine oxidase (SMOX), which generates spermidine (Spd), regulates colitis.	Spermidine	60-70	spermine oxidase	Mus musculus	19-35
34767785-2	2022	We have shown that spermine oxidase (SMOX), which generates spermidine (Spd), regulates colitis.	Spermidine	60-70	spermine oxidase	Mus musculus	37-41
34767785-2	2022	We have shown that spermine oxidase (SMOX), which generates spermidine (Spd), regulates colitis.	Spermidine	72-75	spermine oxidase	Mus musculus	19-35
34767785-2	2022	We have shown that spermine oxidase (SMOX), which generates spermidine (Spd), regulates colitis.	Spermidine	72-75	spermine oxidase	Mus musculus	37-41
34572487-2	2021	A transgenic mouse overexpressing spermine oxidase (SMOX, which specifically oxidizes spermine) in the neocortex neurons (Dach-SMOX mouse) was proved to be a model of increased susceptibility to excitotoxic injury.	Spermine	86-94	spermine oxidase	Mus musculus	52-56
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Spermine	228-236	spermine oxidase	Mus musculus	391-395
34572487-2	2021	A transgenic mouse overexpressing spermine oxidase (SMOX, which specifically oxidizes spermine) in the neocortex neurons (Dach-SMOX mouse) was proved to be a model of increased susceptibility to excitotoxic injury.	Spermine	86-94	spermine oxidase	Mus musculus	127-131
34572487-5	2021	CONCLUSIONS: Chronic activation of SMOX in neurons leads to major changes in the astrocyte processes including reduced spermine levels, increased calcium influx through calcium-permeable AMPA receptors, and stimulation of catalase activity.	Spermine	119-127	spermine oxidase	Mus musculus	35-39
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Calcium	74-81	spermine oxidase	Mus musculus	150-154
34572487-5	2021	CONCLUSIONS: Chronic activation of SMOX in neurons leads to major changes in the astrocyte processes including reduced spermine levels, increased calcium influx through calcium-permeable AMPA receptors, and stimulation of catalase activity.	Calcium	146-153	spermine oxidase	Mus musculus	35-39
34572487-5	2021	CONCLUSIONS: Chronic activation of SMOX in neurons leads to major changes in the astrocyte processes including reduced spermine levels, increased calcium influx through calcium-permeable AMPA receptors, and stimulation of catalase activity.	Calcium	169-176	spermine oxidase	Mus musculus	35-39
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Calcium	74-81	spermine oxidase	Mus musculus	188-192
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Calcium	74-81	spermine oxidase	Mus musculus	260-264
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Calcium	74-81	spermine oxidase	Mus musculus	391-395
34572487-4	2021	RESULTS: The main findings are as follows: (i) the presence of functional calcium-permeable AMPA receptors in synaptosomes from both control and Dach-SMOX mice, and in gliosomes from Dach-SMOX mice only; (ii) reduced content of spermine in gliosomes from Dach-SMOX mice; and (iii) down-regulation and up-regulation of catalase activity in synaptosomes and gliosomes, respectively, from Dach-SMOX mice.	Spermine	228-236	spermine oxidase	Mus musculus	150-154
35204705-4	2022	Spermine oxidase, specifically oxidized spermine, is a neuromodulator of several types of ion channel and ionotropic glutamate receptors, and its deregulated activity has been linked to several brain pathologies, including epilepsy.	Spermine	40-48	spermine oxidase	Mus musculus	0-16
35216248-7	2022	Furthermore, SMOX inhibition upregulated antioxidant signaling (indicated by elevated Nrf2 and HO-1 levels) and reduced protein-conjugated acrolein in excitotoxic retinas.	Acrolein	139-147	spermine oxidase	Mus musculus	13-17
35216248-8	2022	In vitro studies using C8-B4 cells showed changes in cellular morphology and increased reactive oxygen species formation in response to acrolein (a product of SMOX activity) treatment.	Oxygen	96-102	spermine oxidase	Mus musculus	159-163
35216248-8	2022	In vitro studies using C8-B4 cells showed changes in cellular morphology and increased reactive oxygen species formation in response to acrolein (a product of SMOX activity) treatment.	Acrolein	136-144	spermine oxidase	Mus musculus	159-163
35204705-5	2022	The Dach-SMOX mouse line was generated using a Cre/loxP-based recombination approach to study the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain.	Spermine	165-173	spermine oxidase	Mus musculus	9-13
31991839-0	2020	Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice.	Retinaldehyde	77-93	spermine oxidase	Mus musculus	30-46
31197571-5	2020	In this study, we analysed the effect of spermine oxidase over-expression in a different epileptic model, pentylenetetrazole.	Pentylenetetrazole	106-124	spermine oxidase	Mus musculus	41-57
31197571-10	2020	This research points out the role of spermine oxidase, as a hydrogen peroxide producer, in the oxidative stress during epilepsy.	Hydrogen Peroxide	60-77	spermine oxidase	Mus musculus	37-53
7238568-2	1981	A method for the detection of spermine oxidase activity was developed using the amino acid analyzer to follow the changes in composition of incubation mixture of spermine or spermidine.	Spermidine	174-184	spermine oxidase	Mus musculus	30-46
7238568-5	1981	Oxidation was inhibited by the spermine oxidase inhibitors hydroxylamine and isonicotinic acid hydrazide, and inhibition of the immune response was no longer evident suggesting that the inhibitory material was a product of the action of the enzyme on spermic and spermidine.	Hydroxylamine	59-72	spermine oxidase	Mus musculus	31-47
7238568-5	1981	Oxidation was inhibited by the spermine oxidase inhibitors hydroxylamine and isonicotinic acid hydrazide, and inhibition of the immune response was no longer evident suggesting that the inhibitory material was a product of the action of the enzyme on spermic and spermidine.	Isoniazid	77-104	spermine oxidase	Mus musculus	31-47
7238568-5	1981	Oxidation was inhibited by the spermine oxidase inhibitors hydroxylamine and isonicotinic acid hydrazide, and inhibition of the immune response was no longer evident suggesting that the inhibitory material was a product of the action of the enzyme on spermic and spermidine.	spermic	251-258	spermine oxidase	Mus musculus	31-47
7238568-5	1981	Oxidation was inhibited by the spermine oxidase inhibitors hydroxylamine and isonicotinic acid hydrazide, and inhibition of the immune response was no longer evident suggesting that the inhibitory material was a product of the action of the enzyme on spermic and spermidine.	Spermidine	263-273	spermine oxidase	Mus musculus	31-47
7238568-7	1981	Mouse amniotic fluid was found to contain high levels of a spermine oxidase having a somewhat different specificity than that in FCS, and this enzyme produced a noncytotoxic immune inhibitor from cadaverine, spermidine and spermine.	Cadaverine	196-206	spermine oxidase	Mus musculus	59-75
7238568-7	1981	Mouse amniotic fluid was found to contain high levels of a spermine oxidase having a somewhat different specificity than that in FCS, and this enzyme produced a noncytotoxic immune inhibitor from cadaverine, spermidine and spermine.	Spermidine	208-218	spermine oxidase	Mus musculus	59-75
33153123-4	2020	In this study, we evaluated the expression profile of circular and linear SMOX in both C2C12 differentiation and dexamethasone-induced myotubes atrophy.	Dexamethasone	113-126	spermine oxidase	Mus musculus	74-78
32350444-5	2020	We now used a molecular approach to directly address the role of SMOX, and demonstrate that Smox-deficient mice exhibit significant reductions of gastric spermidine levels and H. pylori-induced inflammation.	Spermidine	154-164	spermine oxidase	Mus musculus	92-96
32061808-7	2020	The SMOX level was negatively correlated with spermine content, which is involved in muscle atrophy, and was higher in EDL than Sol, even in the 1 g group.	Spermine	46-54	spermine oxidase	Mus musculus	4-8
32061808-8	2020	These results indicated that the contribution of SMOX to the regulation of spermidine and spermine contents in Sol and EDL differed.	Spermidine	75-85	spermine oxidase	Mus musculus	49-53
32061808-8	2020	These results indicated that the contribution of SMOX to the regulation of spermidine and spermine contents in Sol and EDL differed.	Spermine	90-98	spermine oxidase	Mus musculus	49-53
31197571-4	2020	The transgenic mouse line Dach-SMOX, with CD1 background, specifically overexpressing spermine oxidase in brain cortex, has been proven to be highly susceptible to epileptic seizures and excitotoxic stress induced by kainic acid.	1,2-cyclohexanediamine	26-30	spermine oxidase	Mus musculus	31-35
31197571-4	2020	The transgenic mouse line Dach-SMOX, with CD1 background, specifically overexpressing spermine oxidase in brain cortex, has been proven to be highly susceptible to epileptic seizures and excitotoxic stress induced by kainic acid.	1,2-cyclohexanediamine	26-30	spermine oxidase	Mus musculus	86-102
31197571-4	2020	The transgenic mouse line Dach-SMOX, with CD1 background, specifically overexpressing spermine oxidase in brain cortex, has been proven to be highly susceptible to epileptic seizures and excitotoxic stress induced by kainic acid.	Kainic Acid	217-228	spermine oxidase	Mus musculus	31-35
31197571-4	2020	The transgenic mouse line Dach-SMOX, with CD1 background, specifically overexpressing spermine oxidase in brain cortex, has been proven to be highly susceptible to epileptic seizures and excitotoxic stress induced by kainic acid.	Kainic Acid	217-228	spermine oxidase	Mus musculus	86-102
31991839-4	2020	We have demonstrated that spermine oxidase (SMOX), a mediator of polyamine oxidation is critically involved in causing neurovascular damage in the retina.	Polyamines	65-74	spermine oxidase	Mus musculus	26-42
31991839-4	2020	We have demonstrated that spermine oxidase (SMOX), a mediator of polyamine oxidation is critically involved in causing neurovascular damage in the retina.	Polyamines	65-74	spermine oxidase	Mus musculus	44-48
31991839-6	2020	Utilizing the streptozotocin-induced mouse model of diabetes, the impact of the SMOX inhibitor, MDL 72527, on neuronal damage and dysfunction in the diabetic retina was investigated.	MDL 72527	96-105	spermine oxidase	Mus musculus	80-84
31545418-6	2019	It has been shown that in NB cell lines and in a total-spermine oxidase (SMOX) transgenic mouse model, SMOX overexpression induces cellular stress via reactive oxygen species (ROS) imbalance.	Reactive Oxygen Species	151-174	spermine oxidase	Mus musculus	49-71
30829081-0	2019	Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.	Polyamines	26-35	spermine oxidase	Mus musculus	63-79
30829081-0	2019	Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.	methoctramine	81-94	spermine oxidase	Mus musculus	63-79
30829081-3	2019	Methoctramine (10), a well-known muscarinic M2 receptor antagonist, emerged as the most potent competitive PAOX inhibitor known so far (Ki = 10 nM), endowed with very good selectivity compared with SMOX (Ki=1.2 muM vs SMOX).	methoctramine	0-13	spermine oxidase	Mus musculus	218-222
30829081-5	2019	Methoctramine is a very promising tool in the design of drugs targeting the polyamine catabolism pathway, both to understand the physio-pathological role of PAOX vs SMOX and for pharmacological applications, being the polyamine pathway involved in various pathologies.	methoctramine	0-13	spermine oxidase	Mus musculus	165-169
30829081-5	2019	Methoctramine is a very promising tool in the design of drugs targeting the polyamine catabolism pathway, both to understand the physio-pathological role of PAOX vs SMOX and for pharmacological applications, being the polyamine pathway involved in various pathologies.	Polyamines	76-85	spermine oxidase	Mus musculus	165-169
31545418-6	2019	It has been shown that in NB cell lines and in a total-spermine oxidase (SMOX) transgenic mouse model, SMOX overexpression induces cellular stress via reactive oxygen species (ROS) imbalance.	Reactive Oxygen Species	151-174	spermine oxidase	Mus musculus	103-107
31545418-6	2019	It has been shown that in NB cell lines and in a total-spermine oxidase (SMOX) transgenic mouse model, SMOX overexpression induces cellular stress via reactive oxygen species (ROS) imbalance.	Reactive Oxygen Species	176-179	spermine oxidase	Mus musculus	49-71
31545418-6	2019	It has been shown that in NB cell lines and in a total-spermine oxidase (SMOX) transgenic mouse model, SMOX overexpression induces cellular stress via reactive oxygen species (ROS) imbalance.	Reactive Oxygen Species	176-179	spermine oxidase	Mus musculus	103-107
31311033-12	2019	Proteomics revealed increased efflux pumps in MDR9 versus PAO1; GLY reduced their mRNA expression levels and EB suggested decreased activity.	Glycyrrhizic Acid	64-67	spermine oxidase	Mus musculus	58-62
29477597-1	2018	Inhibitors for polyamine oxidizing enzymes, spermine oxidase (SMOX) and N1-acetylpolyamine oxidase (PAOX), were designed and evaluated for their effectiveness in a photochemically induced thrombosis (PIT) mouse model.	Polyamines	15-24	spermine oxidase	Mus musculus	44-60
29923661-1	2018	AIM: The polyamine catabolic enzyme, spermine oxidase (SMOX) is upregulated in chronic inflammatory conditions and linked to increased reactive oxygen species and DNA damage in various forms of cancers.	Polyamines	9-18	spermine oxidase	Mus musculus	55-59
29923661-1	2018	AIM: The polyamine catabolic enzyme, spermine oxidase (SMOX) is upregulated in chronic inflammatory conditions and linked to increased reactive oxygen species and DNA damage in various forms of cancers.	Reactive Oxygen Species	135-158	spermine oxidase	Mus musculus	55-59
29923661-11	2018	Furthermore, we showed that SMOX might exert its function by regulating the phosphatidylinositol 3"-kinase/protein kinase B signaling pathway.	Phosphatidylinositols	76-96	spermine oxidase	Mus musculus	28-32
29729200-10	2018	Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them.	Polyamines	70-79	spermine oxidase	Mus musculus	55-59
29729200-10	2018	Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them.	N(1),N(11)-diethylnorspermine	89-110	spermine oxidase	Mus musculus	55-59
29729200-10	2018	Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them.	diminazene aceturate	244-251	spermine oxidase	Mus musculus	55-59
29566247-7	2018	Comparative gene expression analysis reveals that S-Adenosylmethionine decarboxylase (Amd1) and Spermine oxidase (Smox), two components of polyamine pathway metabolism, are downregulated in the TA but not in the triceps of dy2j/dy2j mice.	Polyamines	139-148	spermine oxidase	Mus musculus	96-112
29566247-7	2018	Comparative gene expression analysis reveals that S-Adenosylmethionine decarboxylase (Amd1) and Spermine oxidase (Smox), two components of polyamine pathway metabolism, are downregulated in the TA but not in the triceps of dy2j/dy2j mice.	Polyamines	139-148	spermine oxidase	Mus musculus	114-118
29397558-0	2018	Glutamate Excitotoxicity Linked to Spermine Oxidase Overexpression.	Glutamic Acid	0-9	spermine oxidase	Mus musculus	35-51
29397558-2	2018	To identify new potential proteins that could represent key factors in excitotoxic stress and to study the relationship between polyamine catabolism and excitotoxic damage, a novel transgenic mouse line overexpressing spermine oxidase enzyme in the neocortex (Dach-SMOX) has been engineered.	Polyamines	128-137	spermine oxidase	Mus musculus	218-234
29397558-4	2018	In Dach-SMOX astrocytes and neurons, an alteration of the phosphorylated and non-phosphorylated subunits of glutamate receptors increases the kainic acid response in these mice.	Kainic Acid	142-153	spermine oxidase	Mus musculus	8-12
29397558-6	2018	Sulfasalazine, a system xc- transporter inhibitor, was shown to revert the increased susceptibility of Dach-SMOX mice treated with kainic acid.	Sulfasalazine	0-13	spermine oxidase	Mus musculus	108-112
29397558-6	2018	Sulfasalazine, a system xc- transporter inhibitor, was shown to revert the increased susceptibility of Dach-SMOX mice treated with kainic acid.	Kainic Acid	131-142	spermine oxidase	Mus musculus	108-112
29397558-7	2018	We demonstrated that astrocytes play a crucial role in this process: neuronal spermine oxidase overexpression resulted in an alteration of glutamate excitability, in glutamate uptake and efflux in astrocytes involved in the synapse.	Glutamic Acid	139-148	spermine oxidase	Mus musculus	78-94
29397558-7	2018	We demonstrated that astrocytes play a crucial role in this process: neuronal spermine oxidase overexpression resulted in an alteration of glutamate excitability, in glutamate uptake and efflux in astrocytes involved in the synapse.	Glutamic Acid	166-175	spermine oxidase	Mus musculus	78-94
29922289-3	2018	The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects.	Spermine	11-19	spermine oxidase	Mus musculus	29-33
29922289-3	2018	The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects.	Spermidine	68-78	spermine oxidase	Mus musculus	11-27
29922289-3	2018	The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects.	Spermidine	68-78	spermine oxidase	Mus musculus	29-33
29922289-3	2018	The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects.	Polyamines	109-118	spermine oxidase	Mus musculus	11-27
29922289-3	2018	The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects.	Polyamines	109-118	spermine oxidase	Mus musculus	29-33
29922289-8	2018	In contrast, with DSS, Smox-/- mice exhibited substantial mortality, and increased body weight loss, colon weight/length, and histologic damage.	Dextran Sulfate	18-21	spermine oxidase	Mus musculus	23-27
29922289-10	2018	In DSS colitis, increased levels of IL-6, CSF3, and IL-17 were further increased in Smox-/- mice.	Dextran Sulfate	3-6	spermine oxidase	Mus musculus	84-88
29922289-11	2018	In both models, putrescine and spermidine were increased in WT mice; in Smox-/- mice, the main effect was decreased spermidine and spermidine/spermine ratio.	Spermidine	116-126	spermine oxidase	Mus musculus	72-76
29922289-11	2018	In both models, putrescine and spermidine were increased in WT mice; in Smox-/- mice, the main effect was decreased spermidine and spermidine/spermine ratio.	Spermidine	116-126	spermine oxidase	Mus musculus	72-76
29922289-11	2018	In both models, putrescine and spermidine were increased in WT mice; in Smox-/- mice, the main effect was decreased spermidine and spermidine/spermine ratio.	Spermine	142-150	spermine oxidase	Mus musculus	72-76
29922289-13	2018	Our studies indicate that SMOX has immunomodulatory effects in experimental colitis via polyamine flux.	Polyamines	88-97	spermine oxidase	Mus musculus	26-30
29477597-1	2018	Inhibitors for polyamine oxidizing enzymes, spermine oxidase (SMOX) and N1-acetylpolyamine oxidase (PAOX), were designed and evaluated for their effectiveness in a photochemically induced thrombosis (PIT) mouse model.	Polyamines	15-24	spermine oxidase	Mus musculus	62-66
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	n1-nonyl-1,4-diaminobutane	0-26	spermine oxidase	Mus musculus	125-129
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	n1-tridecyl-1,4-diaminobutane	38-67	spermine oxidase	Mus musculus	125-129
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	MDL-72527 free base	156-199	spermine oxidase	Mus musculus	125-129
29477597-2	2018	N1-Nonyl-1,4-diaminobutane (C9-4) and N1-tridecyl-1,4-diaminobutane (C13-4) competitively inhibited the activity of PAOX and SMOX in a manner comparable to N1,N4-bis(2,3-butadienyl)-1,4-butanediamine (MDL72527), an irreversible inhibitor of both enzymes.	MDL 72527	201-209	spermine oxidase	Mus musculus	125-129
29443878-6	2018	Of note, the SMOX reaction product spermidine appears to be involved in skeletal muscle atrophy/hypertrophy.	Spermidine	35-45	spermine oxidase	Mus musculus	13-17
28886181-2	2017	The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with cisplatin.	Cisplatin	181-190	spermine oxidase	Mus musculus	112-128
28920425-3	2017	More importantly, 1 can also be used to detect endogenous peroxynitrite generated in Pseudomonas aeruginosa (PAO1)-infected mouse bone marrow-derived neutrophils.	Peroxynitrous Acid	58-71	spermine oxidase	Mus musculus	109-113
28886181-2	2017	The expression of enzymes involved in polyamine catabolism, spermidine/spermine N1-acetyltransferase (SSAT) and spermine oxidase (SMOX) increase in the kidneys of mice treated with cisplatin.	Cisplatin	181-190	spermine oxidase	Mus musculus	130-134
28043891-1	2017	Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal.	Spermine	26-34	spermine oxidase	Mus musculus	0-16
28043891-1	2017	Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal.	Hydrogen Peroxide	46-50	spermine oxidase	Mus musculus	0-16
28043891-1	2017	Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal.	Spermidine	52-62	spermine oxidase	Mus musculus	0-16
28043891-1	2017	Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal.	3-aminopropionaldehyde	68-83	spermine oxidase	Mus musculus	0-16
28043891-5	2017	The spermine oxidase overexpression was revealed by beta-Gal staining and reverse-transcriptase/PCR analysis, in all tissues analysed.	beta-D-galactose	52-60	spermine oxidase	Mus musculus	4-20
28043891-9	2017	Chronic H2O2 production induced by spermine oxidase overexpression leads to a cellular redox state imbalance in both tissues, although they show different redox adaptation.	Hydrogen Peroxide	8-12	spermine oxidase	Mus musculus	35-51
26530396-1	2016	Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced epileptic seizures.	Kainic Acid	156-163	spermine oxidase	Mus musculus	31-47
26530396-1	2016	Transgenic mice overexpressing spermine oxidase (SMO) in the cerebral cortex (Dach-SMO mice) showed increased vulnerability to excitotoxic brain injury and kainate-induced epileptic seizures.	Kainic Acid	156-163	spermine oxidase	Mus musculus	49-52
26530396-2	2016	To investigate the mechanisms by which SMO overexpression leads to increased susceptibility to kainate excitotoxicity and seizure, in the cerebral cortex of Dach-SMO and control mice we assessed markers for astrocyte proliferation and neuron loss, and the ability of kainate to evoke glutamate release from nerve terminals and astrocyte processes.	Glutamic Acid	284-293	spermine oxidase	Mus musculus	39-42
26530396-5	2016	The main findings in the cerebral cortex of Dach-SMO mice as compared to controls are the following: astrocyte activation and neuron loss; increased oxidative stress and activation of defense mechanisms involving both neurons and astrocytes; increased susceptibility to kainate-evoked cortical epileptogenic activity, dependent on astrocyte function; appearance of a glutamate-releasing response to kainate from astrocyte processes due to activation of Ca(2+)-permeable AMPA receptors in Dach-SMO mice.	Kainic Acid	270-277	spermine oxidase	Mus musculus	49-52
26530396-5	2016	The main findings in the cerebral cortex of Dach-SMO mice as compared to controls are the following: astrocyte activation and neuron loss; increased oxidative stress and activation of defense mechanisms involving both neurons and astrocytes; increased susceptibility to kainate-evoked cortical epileptogenic activity, dependent on astrocyte function; appearance of a glutamate-releasing response to kainate from astrocyte processes due to activation of Ca(2+)-permeable AMPA receptors in Dach-SMO mice.	Glutamic Acid	367-376	spermine oxidase	Mus musculus	49-52
26530396-5	2016	The main findings in the cerebral cortex of Dach-SMO mice as compared to controls are the following: astrocyte activation and neuron loss; increased oxidative stress and activation of defense mechanisms involving both neurons and astrocytes; increased susceptibility to kainate-evoked cortical epileptogenic activity, dependent on astrocyte function; appearance of a glutamate-releasing response to kainate from astrocyte processes due to activation of Ca(2+)-permeable AMPA receptors in Dach-SMO mice.	Kainic Acid	399-406	spermine oxidase	Mus musculus	49-52
26530396-6	2016	We conclude that reactive astrocytosis and activation of glutamate release from astrocyte processes might contribute, together with increased reactive oxygen species production, to the vulnerability to kainate excitotoxicity in Dach-SMO mice.	Glutamic Acid	57-66	spermine oxidase	Mus musculus	233-236
27403445-12	2016	In culture, macrophages exposed to cigarette smoke and oxygen also demonstrated decreased TNF-alpha secretion and enhanced phagocytosis of PAO1 bacteria.	Oxygen	55-61	spermine oxidase	Mus musculus	139-143
27590852-0	2016	Decrease in acrolein toxicity based on the decline of polyamine oxidases.	Acrolein	12-20	spermine oxidase	Mus musculus	54-72
27590852-5	2016	In the Neuro2a-ATD2 cells, the IC50 of acrolein increased from 4.2 to 6.8muM, and the levels of FosB and C/EBPbeta - transcription factors involved in the transcription of AcPAO and SMO genes - were reduced.	Acrolein	39-47	spermine oxidase	Mus musculus	182-185
27590852-9	2016	Furthermore, transfection of the cDNA for AcPAO or SMO into Neuro2a cells increased the toxicity of acrolein.	Acrolein	100-108	spermine oxidase	Mus musculus	51-54
27590852-10	2016	These results suggest that acrolein is mainly produced from polyamines by PAO.	Acrolein	27-35	spermine oxidase	Mus musculus	74-77
27590852-10	2016	These results suggest that acrolein is mainly produced from polyamines by PAO.	Polyamines	60-70	spermine oxidase	Mus musculus	74-77