PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
6110664-2	1981	We have investigated the effects of estrogen on three key regulatory enzymes in lipid biosynthesis, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, the major regulatory enzyme in cholesterol and isoprenoid synthesis, and acetyl-CoA carboxylase and fatty acid synthetase, which regulate fatty acid biosynthesis.	Cholesterol	179-190	3-hydroxy-3-methylglutaryl-CoA reductase L homeolog	Xenopus laevis	100-146
2124543-4	1990	The membrane association of p21rho and its biological activity were inhibited by lovastatin, an inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase.	Lovastatin	81-91	3-hydroxy-3-methylglutaryl-CoA reductase L homeolog	Xenopus laevis	113-160