PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33152341-4	2021	NaB administration inhibited total HDAC activity and enhanced acetylation level of histones specifically in histone H4, accompanying the increase of transcription levels of immediate-early genes (IEGs) (c-fos and Arc) and neurotrophins (BDNF and NT-4) crucial for neuroplasticity in the motor cortex.	nab	0-3	LOC102641229	Mus musculus	108-118
34264868-4	2021	In vitro, defibrotide counteracted endothelial cell activation and pyroptosis-mediated cell death, whether triggered by purified NETs or recombinant histone H4.	defibrotide	10-21	LOC102641229	Mus musculus	149-159
34264868-6	2021	Mechanistically, defibrotide demonstrated direct and tight binding to histone H4 as detected by both electrophoretic mobility shift assay and surface plasmon resonance.	defibrotide	17-28	LOC102641229	Mus musculus	70-80
33655266-4	2021	In vitro , defibrotide counteracted endothelial cell activation and cell death, whether triggered by purified NETs, COVID-19 serum containing high levels of NETs, or recombinant histone H4.	defibrotide	11-22	LOC102641229	Mus musculus	178-188
33655266-6	2021	Mechanistically, defibrotide demonstrated direct and tight binding to histone H4 as detected by both electrophoretic mobility shift assay and surface plasmon resonance.	defibrotide	17-28	LOC102641229	Mus musculus	70-80
35073921-0	2022	Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.	Heparitin Sulfate	19-34	LOC102641229	Mus musculus	0-10
35073921-0	2022	Histone H4 induces heparan sulfate degradation by activating heparanase in chlorine gas-induced acute respiratory distress syndrome.	Chlorine	75-83	LOC102641229	Mus musculus	0-10
35073921-10	2022	RESULTS: Histone H4 in BALF and plasma increased evidently after Cl2 inhalation.	Chlorine	65-68	LOC102641229	Mus musculus	9-19
35073921-12	2022	Pretreatment with OGT2115, an HPSE inhibitor, relieved the acute lung injury and HS degradation caused by Cl2 exposure or histone H4 challenge.	OGT 2115	18-25	LOC102641229	Mus musculus	122-132
35073921-16	2022	CONCLUSIONS: Histone H4 is a major pro-inflammatory mediator in Cl2-induced ARDS in mice, and induces HS degradation by activating HPSE via TLRs- and NF-kappaB-signaling pathways.	Chlorine	64-67	LOC102641229	Mus musculus	13-23
35073921-16	2022	CONCLUSIONS: Histone H4 is a major pro-inflammatory mediator in Cl2-induced ARDS in mice, and induces HS degradation by activating HPSE via TLRs- and NF-kappaB-signaling pathways.	Heparitin Sulfate	102-104	LOC102641229	Mus musculus	13-23
33062035-0	2020	Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome.	Chlorine	58-66	LOC102641229	Mus musculus	0-10
32378528-3	2020	Histone H4 lysine 20 monomethylation (H4K20me1) is involved in DNA damage repair and regulation of gene expression.	Lysine	11-17	LOC102641229	Mus musculus	0-10
33062035-10	2020	The levels of circulating histone H4 were positively correlated with Cl2 concentrations.	Chlorine	69-72	LOC102641229	Mus musculus	26-36
33062035-16	2020	Conclusions: Circulating histone H4 played a pro-inflammatory role in ARDS caused by Cl2.	Chlorine	85-88	LOC102641229	Mus musculus	25-35
33062035-4	2020	The present study aimed to examine the pathogenic role of histone H4 in Cl2-induced ARDS.	Chlorine	72-75	LOC102641229	Mus musculus	58-68
29409673-4	2018	First, to study the effects of OGG1 on histone modification, the protein levels of symmetric dimethylation of histone H4 arginine-3 (H4R3me2s) were determined by western blot analysis following the knockdown or overexpression of OGG1.	h4r3me2s	133-141	LOC102641229	Mus musculus	110-120
31746491-3	2020	To further investigate the correlation between phosphorylated serine 1 of histone H4 (H4S1ph) and sperm maturation, a comparison study was conducted in this work between the healthy and the precocious crabs.	Serine	62-68	LOC102641229	Mus musculus	74-84
30713523-8	2018	The interaction between glucagon and the ER stress protein GRP78 and histone H4 was confirmed through co-immunoprecipitation of secretory granule lysates, and colocalization immunofluorescence confocal microscopy.	Glucagon	24-32	LOC102641229	Mus musculus	69-79
29409673-11	2018	Our data not only illustrate the important roles of OGG1 in histone modification, but also reveal the mechanism by which OGG1 affects PRMT5 binding on H4R3 resulting in the symmetrical dimethylation of histone H4 arginine-3.	Arginine	213-221	LOC102641229	Mus musculus	202-212
12665509-0	2003	Glucose regulates insulin gene transcription by hyperacetylation of histone h4.	Glucose	0-7	LOC102641229	Mus musculus	68-78
23567968-6	2013	Consistently, Western Blot analysis revealed that acetylation of proteins about 53 kDa and 11 kDa in size, corresponding to alpha-tubulin and histone H4 sizes respectively, were increased mainly after oocyte activation and exclusively enhanced by TSA treatment in zygotes.	trichostatin A	247-250	LOC102641229	Mus musculus	142-152
21964251-9	2012	Moreover, in non-stressed Balb/c mice, co-administration of an HDAC inhibitor and fluoxetine, but not fluoxetine alone, elicited antidepressant effects and also triggered changes in histone H4 expression that were similar to those provoked by fluoxetine treatment of mice exposed to early life stress.	Fluoxetine	82-92	LOC102641229	Mus musculus	182-192
26968571-0	2016	Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach.	Lysine	32-38	LOC102641229	Mus musculus	77-87
26968571-1	2016	We developed a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the site-specific quantification of lysine acetylation in the N-terminal region of histone H4 by combining chemical derivatization at the protein and peptide levels with digestion using chymotrypsin and trypsin.	Lysine	129-135	LOC102641229	Mus musculus	176-186
26159193-0	2015	Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimer"s Mice and in Human Patients.	Lysine	39-45	LOC102641229	Mus musculus	25-35
26159193-4	2015	The aim of the present study was to examine acetylation of histone H4 at lysine 12 (H4K12) in monocytes in two transgenic AD mouse models (the triple transgenic 3xTg and a model overexpressing amyloid-precursor protein APP with the Swedish-Dutch-Iowa mutations), and to compare with monocytes isolated from human patients with mild cognitive impairment (MCI) and AD.	Lysine	73-79	LOC102641229	Mus musculus	59-69
23402795-4	2013	Using Western blot analysis, we detected global hypoacetylation of histone H3, at lysine residues 9 and 14, and histone H4, at lysine residue 8, in the cortex from juvenile (~24days of age) offspring exposed to polyI:C in utero, but not from adult (3months of age) offspring, which exhibit significant behavioral abnormalities.	Poly I-C	211-218	LOC102641229	Mus musculus	112-122
22067432-4	2011	One such histone mark critical for maintaining chromatin structure is acetylated lysine 16 of histone H4 (AcH4K16), a modification that can disrupt higher order chromatin organization and convert it into a more "relaxed" configuration.	Lysine	81-87	LOC102641229	Mus musculus	94-104
20838874-0	2010	Effect of cryopreservation on acetylation patterns of lysine 12 of histone H4 (acH4K12) in mouse oocytes and zygotes.	lysine 12	54-63	LOC102641229	Mus musculus	67-77
19285668-0	2010	Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development.	Lysine	26-32	LOC102641229	Mus musculus	39-49
12665509-4	2003	We report that exposure of mouse insulinoma 6 cells to high concentrations of glucose results in hyperacetylation of histone H4 at the insulin gene promoter, which correlates with the increased level of insulin gene transcription.	Glucose	78-85	LOC102641229	Mus musculus	117-127
12665509-5	2003	In addition, we demonstrate that hyperacetylation of histone H4 in response to high concentrations of glucose also occurs at the glucose transporter-2 gene promoter.	Glucose	102-109	LOC102641229	Mus musculus	53-63
12665509-8	2003	In summary, our data support the idea that high concentrations of glucose stimulate insulin gene expression by causing hyperacetylation of histone H4 at the insulin gene promoter.	Glucose	66-73	LOC102641229	Mus musculus	139-149
9351883-0	1997	Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.	Triiodothyronine	0-16	LOC102641229	Mus musculus	77-87