PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2739662-1	1989	The glucocorticoid dexamethasone (DEX) causes a rapid, reversible reduction in c-myc mRNA level in the oviducts of estrogen-treated, immature chickens.	Dexamethasone	19-32	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	79-84
2510826-4	1989	The mitogenic effect of 1,25-dihydroxyvitamin D-3 was correlated with an increase in c-myc mRNA and a decrease in c-fos mRNA levels, whereas its inhibitory action on DNA synthesis was accompanied by increased myofibrillar and microsomal protein synthesis and an elevation of creatine kinase activity, the latter suggesting a stimulation of muscle cell differentiation by the sterol.	1,25-dihydroxyvitamin D	24-47	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	85-90
2739662-1	1989	The glucocorticoid dexamethasone (DEX) causes a rapid, reversible reduction in c-myc mRNA level in the oviducts of estrogen-treated, immature chickens.	Dexamethasone	34-37	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	79-84
2739662-2	1989	The c-myc mRNA level begins to decrease by 5 min after injection of 0.5 mg DEX, reaches a minimum of 10% of the control value by 30 min, and returns to 30-40% of the control value by 4 h post injection.	Dexamethasone	75-78	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	4-9
2739662-3	1989	This rapid effect of DEX on the c-myc mRNA level occurs in both diethylstilbestrol-stimulated and diethylstilbestrol-withdrawn oviducts.	Dexamethasone	21-24	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	32-37
2739662-3	1989	This rapid effect of DEX on the c-myc mRNA level occurs in both diethylstilbestrol-stimulated and diethylstilbestrol-withdrawn oviducts.	Diethylstilbestrol	64-82	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	32-37
2739662-3	1989	This rapid effect of DEX on the c-myc mRNA level occurs in both diethylstilbestrol-stimulated and diethylstilbestrol-withdrawn oviducts.	Diethylstilbestrol	98-116	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	32-37
2739662-4	1989	The effect is dose dependent, with reduction of the c-myc mRNA measured with as little as 10 micrograms DEX injection (0.03 micrograms/g BW).	Dexamethasone	104-107	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	52-57
2739662-6	1989	The effect is also tissue specific with liver displaying an increase of 170% of control values in c-myc mRNA level by 30 min after injection of 0.5 mg DEX.	Dexamethasone	151-154	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	98-103
2739662-7	1989	The reduction of avian oviduct c-myc mRNA levels by DEX may play a role in glucocorticoid inhibition of cell proliferation in this tissue.	Dexamethasone	52-55	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	31-36
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	20-27	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	39-44
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	20-27	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	110-115
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	20-27	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	110-115
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	81-88	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	39-44
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	81-88	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	110-115
2739662-8	1989	The rapidity of the steroid effects on c-myc expression makes it likely that the steroid-induced reduction of c-myc mRNA levels represents a direct primary action of the steroid-receptor complex on the c-myc gene expression.	Steroids	81-88	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	110-115
2462725-4	1988	Approximately 90% of c-myc transcription begins in the promoter of the ALV proviral long terminal repeat (LTR) and this mRNA has a half-life of approximately 25 minutes in actinomycin D chase experiments.	Dactinomycin	172-185	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	21-26
3162308-4	1988	Levels of c-myc mRNA began to decrease in response to progesterone by 10 min after injection.	Progesterone	54-66	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	10-15
3253062-0	1988	Steroid-induced cell proliferation in vivo is associated with increased c-myc proto-oncogene transcript abundance.	Steroids	0-7	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	72-77
3253062-3	1988	Experiments reported here indicate that when cells of the immature chicken oviduct are induced to undergo rapid in vivo proliferation by application of the estrogen hormone 17 beta-estradiol, the onset of this proliferation is associated with a rapid, large, and transient increase in c-myc transcript abundance.	Estradiol	176-190	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	285-290
3253062-5	1988	We conclude that the abundance of c-myc transcripts in vivo correlates well with the degree of cell proliferation induced by steroid hormone.	Steroids	125-140	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	34-39
3019003-2	1986	The CMII v-myc and the chicken c-myc alleles differ in their shared coding sequences by a single nucleotide substitution causing a glutamic acid/alanine exchange in the predicted sequences of the corresponding protein products.	Glutamic Acid	131-144	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	31-36
3330784-4	1987	By constructing avian retroviral genomes expressing hybrid gag-myc oncogenes, in which all or parts of the v-myc domains were replaced by corresponding parts of c-myc, we show here that a substitution of threonine 61 of c-myc for a methionine (as in v-mycmc29) significantly enhances the fibroblast transforming capacity of the recombinant oncogene.	Threonine	204-213	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	161-166
3330784-4	1987	By constructing avian retroviral genomes expressing hybrid gag-myc oncogenes, in which all or parts of the v-myc domains were replaced by corresponding parts of c-myc, we show here that a substitution of threonine 61 of c-myc for a methionine (as in v-mycmc29) significantly enhances the fibroblast transforming capacity of the recombinant oncogene.	Threonine	204-213	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	220-225
3330784-4	1987	By constructing avian retroviral genomes expressing hybrid gag-myc oncogenes, in which all or parts of the v-myc domains were replaced by corresponding parts of c-myc, we show here that a substitution of threonine 61 of c-myc for a methionine (as in v-mycmc29) significantly enhances the fibroblast transforming capacity of the recombinant oncogene.	Methionine	232-242	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	220-225
3817014-2	1987	Hybridization of a 32P-labeled v-myc viral oncogene DNA probe to RNA extracted from differentiating explants and immobilized on nitrocellulose filters indicates that levels of 2.5 kb c-myc mRNA are transiently elevated 5-10-fold in the differentiating cells.	Phosphorus-32	19-22	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	183-188
3817014-3	1987	Increased levels of c-myc mRNA are observed within 30 min of the initiation of differentiation in vitro and persist for 8-9 h. Thymidine labeling of nuclei in differentiating explants indicates that entry of cells into S phase is inhibited during this period, as differentiating cells complete a final round of mitosis and withdraw from the cell cycle.	Thymidine	127-136	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	20-25
3019003-2	1986	The CMII v-myc and the chicken c-myc alleles differ in their shared coding sequences by a single nucleotide substitution causing a glutamic acid/alanine exchange in the predicted sequences of the corresponding protein products.	Alanine	145-152	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	31-36
26663639-4	2016	In NMDA-damaged retinas where MGPCs are known to form, we find dynamic changes in retinal levels of potential readouts of Wnt-signaling, including dkk1, dkk3, axin2, c-myc, tcf-1, and cd44.	N-Methylaspartate	3-7	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	166-171
3739230-5	1986	The nucleotide sequence of the myc-env junction fragment of another similar and independently generated MH2 mutant showed similarly 9 nucleotides of homology between the env and myc sequences at the recombination point that took place at another site, suggesting that a homologous recombination occurred between MH2 and RAV-1 viruses to generate MH2-PA200 and similar mutants.	mh2-pa200	346-355	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	31-34
3739230-5	1986	The nucleotide sequence of the myc-env junction fragment of another similar and independently generated MH2 mutant showed similarly 9 nucleotides of homology between the env and myc sequences at the recombination point that took place at another site, suggesting that a homologous recombination occurred between MH2 and RAV-1 viruses to generate MH2-PA200 and similar mutants.	mh2-pa200	346-355	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	178-181
6310159-3	1983	All T1 oligonucleotides mapping within the 1.3-kilobase coding region of MC29 v-myc have homologous counterparts in the RNAs of all MC29 subgroup viruses and in c-myc.	Oligonucleotides	7-23	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	161-166
29158522-0	2017	MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting.	mir-17-5p	0-9	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	93-98
15811177-8	2005	The addition of LiCl inhibited GSK3 and successfully restored the levels of ERK in v-Myc and c-Myc transformed cells to those found in non-transformed cells.	Lithium Chloride	16-20	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	85-88
19444914-6	2009	Wild-type PLZF downregulates the MAPK pathway and activates Akt, resulting in reduced phosphorylation on serine 62 of Myc by Erk and on threonine 58 by glycogen synthase kinase 3beta.	Serine	105-111	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	118-121
15811177-8	2005	The addition of LiCl inhibited GSK3 and successfully restored the levels of ERK in v-Myc and c-Myc transformed cells to those found in non-transformed cells.	Lithium Chloride	16-20	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	93-98
12563997-1	1999	OBJECTIVE: To study the effect of c-myc gene expression during hair cell (HC) regeneration in the chick basilar papilla (BP) following getamicin ototoxicity.	getamicin	135-144	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	34-39
11741312-1	2001	It has been recently shown that the fast non-genomic responses of 1,25(OH)(2)-vitamin D(3) [1,25(OH)(2)D(3)] in skeletal muscle cells involve tyrosine phosphorylation of MAP kinase (ERK1/2), c-Src kinase and the oncoprotein c-myc.	Tyrosine	142-150	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	224-229
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	237-245	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	117-122
11741312-3	2001	Coimmunoprecipitation experiments revealed that 1,25(OH)(2)D(3) induces the formation of complexes between c-Src and c-myc, in agreement with the above results and previous studies showing hormone-dependent association between c-Src and tyrosine phosphorylated VDR and c-Src mediated c-myc tyrosine phosphorylation.	Tyrosine	290-298	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	117-122
10964910-7	2000	The sterol-induced increase in tyrosine phosphorylation of c-myc, a finding not reported before for cell growth regulators, was totally suppressed by the specific Src inhibitor PP1.	Sterols	4-10	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	59-64
10964910-7	2000	The sterol-induced increase in tyrosine phosphorylation of c-myc, a finding not reported before for cell growth regulators, was totally suppressed by the specific Src inhibitor PP1.	Tyrosine	31-39	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	59-64
12211441-7	2002	Conversely, in the HD-11EM chicken v-Myc transformed preosteoclast cell line, the full-length TRAP promoter transcription was increased when endogenous v-Myc levels were decreased in response to pretreatment of these cells with 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3].	Calcitriol	228-257	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	37-40
12211441-7	2002	Conversely, in the HD-11EM chicken v-Myc transformed preosteoclast cell line, the full-length TRAP promoter transcription was increased when endogenous v-Myc levels were decreased in response to pretreatment of these cells with 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3].	Calcitriol	228-257	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	154-157
10942197-4	2000	DNA binding studies and site-directed mutagenesis studies indicated that both the AP-1 and MRE/cMyc elements are important for the sodium arsenite induction, while cobalt chloride induction involves only the AP-1 element.	sodium arsenite	131-146	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	95-99
10942197-6	2000	Site-directed mutagenesis studies showed that, to completely abolish sodium arsenite induction, both the AP-1 and MRE/cMyc elements must be mutated; mutation of either element alone resulted in only a partial effect.	sodium arsenite	69-84	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	118-122
10600159-11	1999	These findings support the hypothesis that the PAO-mediated induction of heme oxygenase-1 is caused by activation of AP-1 and MRE/cMyc elements and may involve nuclear proteins whose states of phosphorylation determine binding to regulatory elements, and thus the level of expression of heme oxygenase-1.	oxophenylarsine	47-50	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	130-134
1618915-5	1992	The higher c-myc concentration in the chick proliferating chondrocytes paralleled the differences in the bromodeoxyuridine labelling index between the two species.	Bromodeoxyuridine	105-122	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	11-16
1363364-1	1992	The c-Myc protein is a potential activator of transcription, with the ability to bind in a heterodimer form with Max to DNA sequences containing the core hexanucleotide sequence CAC(G/A)TG.	hexanucleotide	154-168	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	4-9
1930207-6	1991	In adipose tissue, c-myc levels were negatively correlated with serum glucose, TG and IGF-I, while in muscle a positive correlation with serum glucose and TG was found.	Glucose	70-77	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	19-24
1930207-6	1991	In adipose tissue, c-myc levels were negatively correlated with serum glucose, TG and IGF-I, while in muscle a positive correlation with serum glucose and TG was found.	Triglycerides	79-81	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	19-24
1795697-1	1991	To identify the regions in the chicken c-myc promoter that are necessary for the binding of a nuclear trans-acting factor CTCF--the potential oncogene activator--we used a synthetic analog of the natural binding site that contains three correctly spaced CCCTC-repeats that are known to be involved in CTCF-binding.	ccctc	254-259	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	39-44
34412690-3	2021	The results showed that chTERT upregulated the expression of beta-catenin, Cyclin D1, TCF4 and c-Myc.	chtert	24-30	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	95-100
7794790-7	1995	When these morphologically altered CEF were challenged by superinfection with oncogenic retroviruses, they were resistant to transformation by the nuclear oncogenes jun, fos, junD, myc, and qin but were readily transformed by cytoplasmic oncogenes src, mil/raf, ras, and fps.	cef	35-38	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	181-184
7695196-0	1995	Expression of PDGF and C-myc in atherosclerotic lesions in cholesterol-fed chicken.	Cholesterol	59-70	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	23-28
7921414-0	1994	Expression of platelet-derived growth factor and c-myc in atherosclerotic lesions in cholesterol-fed chickens: immunohistochemical and in situ hybridization study.	Cholesterol	85-96	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	49-54
7921414-2	1994	In cholesterol-fed roosters, intense immunohistochemical reaction for PDGF-B, PDGF receptor, and c-myc was seen in the lipid-rich thickened intimal lesions of the thoracic and abdominal aortas while no significant immunoreaction for PDGF-A was demonstrated in the same lesions.	Cholesterol	3-14	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	97-102