PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23815094-2	2013	The chimaeric polymersomes formed from PEG-PCL-PDEA and PEG-SS-PCL had a monodisperse distribution with average sizes ranging from 95.5 to 199.2 nm depending on PEG-SS-PCL contents.	peg-ss-pcl	161-171	phosphodiesterase 6A	Homo sapiens	47-51
22188099-1	2012	pH and reduction dual-bioresponsive nanosized polymersomes based on poly(ethylene glycol)-SS-poly(2-(diethyl amino)ethyl methacrylate) (PEG-SS-PDEA) diblock copolymers were developed for efficient encapsulation and triggered intracellular release of proteins.	poly(ethylene glycol)-ss-poly(2-(diethyl amino)ethyl methacrylate)	68-134	phosphodiesterase 6A	Homo sapiens	143-147
22188099-2	2012	PEG-SS-PDEA copolymers with PDEA-block molecular weights ranging from 4.7, 6.8, to 9.2 kg/mol were synthesized in a controlled manner via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(diethyl amino)ethyl methacrylate (DEAEMA) using PEG-SS-CPADN (CPADN = 4-cyanopentanoic acid dithionaphthalenoate; M(n) PEG = 1.9 kg/mol) as a macro-RAFT agent.	polyethylene glycol bis(succinimidyl succinate)	0-6	phosphodiesterase 6A	Homo sapiens	7-11
22188099-2	2012	PEG-SS-PDEA copolymers with PDEA-block molecular weights ranging from 4.7, 6.8, to 9.2 kg/mol were synthesized in a controlled manner via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(diethyl amino)ethyl methacrylate (DEAEMA) using PEG-SS-CPADN (CPADN = 4-cyanopentanoic acid dithionaphthalenoate; M(n) PEG = 1.9 kg/mol) as a macro-RAFT agent.	polyethylene glycol bis(succinimidyl succinate)	0-6	phosphodiesterase 6A	Homo sapiens	28-32
22188099-2	2012	PEG-SS-PDEA copolymers with PDEA-block molecular weights ranging from 4.7, 6.8, to 9.2 kg/mol were synthesized in a controlled manner via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(diethyl amino)ethyl methacrylate (DEAEMA) using PEG-SS-CPADN (CPADN = 4-cyanopentanoic acid dithionaphthalenoate; M(n) PEG = 1.9 kg/mol) as a macro-RAFT agent.	Polyethylene Glycols	0-3	phosphodiesterase 6A	Homo sapiens	7-11
22188099-2	2012	PEG-SS-PDEA copolymers with PDEA-block molecular weights ranging from 4.7, 6.8, to 9.2 kg/mol were synthesized in a controlled manner via reversible addition-fragmentation chain transfer (RAFT) polymerization of 2-(diethyl amino)ethyl methacrylate (DEAEMA) using PEG-SS-CPADN (CPADN = 4-cyanopentanoic acid dithionaphthalenoate; M(n) PEG = 1.9 kg/mol) as a macro-RAFT agent.	Polyethylene Glycols	0-3	phosphodiesterase 6A	Homo sapiens	28-32
22188099-5	2012	Notably, both fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (FITC-BSA) and cytochrome C (FITC-CC) proteins could facilely be encapsulated into polymersomes with excellent protein-loading efficiencies, likely as a result of electrostatic interactions between proteins and PDEA.	Fluorescein-5-isothiocyanate	14-40	phosphodiesterase 6A	Homo sapiens	288-292
22188099-5	2012	Notably, both fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (FITC-BSA) and cytochrome C (FITC-CC) proteins could facilely be encapsulated into polymersomes with excellent protein-loading efficiencies, likely as a result of electrostatic interactions between proteins and PDEA.	Fluorescein-5-isothiocyanate	42-46	phosphodiesterase 6A	Homo sapiens	288-292
22188099-5	2012	Notably, both fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (FITC-BSA) and cytochrome C (FITC-CC) proteins could facilely be encapsulated into polymersomes with excellent protein-loading efficiencies, likely as a result of electrostatic interactions between proteins and PDEA.	Fluorescein-5-isothiocyanate	78-82	phosphodiesterase 6A	Homo sapiens	288-292
22188099-5	2012	Notably, both fluorescein isothiocyanate (FITC)-labeled bovine serum albumin (FITC-BSA) and cytochrome C (FITC-CC) proteins could facilely be encapsulated into polymersomes with excellent protein-loading efficiencies, likely as a result of electrostatic interactions between proteins and PDEA.	Fluorescein-5-isothiocyanate	78-82	phosphodiesterase 6A	Homo sapiens	288-292
22188099-8	2012	MTT assays in RAW 264.7 and MCF-7 cells indicated that PEG-SS-PDEA (9.2 k) polymersomes had low cytotoxicity up to a polymer concentration of 300 mug/mL.	monooxyethylene trimethylolpropane tristearate	0-3	phosphodiesterase 6A	Homo sapiens	62-66
22188099-9	2012	Confocal laser scanning microscope (CLSM) observations revealed that FITC-CC-loaded PEG-SS-PDEA (9.2 k) polymersomes efficiently delivered and released proteins into MCF-7 cells following 6 h of incubation.	Fluorescein-5-isothiocyanate	69-73	phosphodiesterase 6A	Homo sapiens	91-95
21631122-1	2011	Submicrometer-sized pH-responsive sterically stabilized polystyrene (PS) latex particles were synthesized by dispersion polymerization in isopropyl alcohol with a poly[2-(diethylamino)ethyl methacrylate]- (PDEA-) based macroinitiator.	Polystyrenes	69-71	phosphodiesterase 6A	Homo sapiens	206-210
21631122-5	2011	Scanning electron microscopy and fluorescence microscopy studies indicated that flocs of the PDEA-PS particles were adsorbed at the surface of these water droplets, leading to stable liquid marbles.	Water	149-154	phosphodiesterase 6A	Homo sapiens	93-97
21776682-2	2011	The DHBC LB films revealed a loose distribution of nano-aggregates with variable geometries below the lower critical solution temperature (LCST) of PDEA (32 degrees C) and low surface pressure (3 mN m(-1)).	dhbc lb	4-11	phosphodiesterase 6A	Homo sapiens	148-152
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	Hydrogen	29-37	phosphodiesterase 6A	Homo sapiens	168-172
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	Hydrogen	29-37	phosphodiesterase 6A	Homo sapiens	216-220
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	poly(2-(diethylamino)ethyl methacrylate)-block-poly(n-isopropyl acrylamide)	91-166	phosphodiesterase 6A	Homo sapiens	168-172
21194703-1	2011	We report on construction of hydrogen-bonded monolayers and multilayers of micelles of the poly(2-(diethylamino)ethyl methacrylate)-block-poly(N-isopropyl acrylamide) (PDEA-b-PNIPAM) with PNIPAM-corona and polybasic PDEA cores.	poly-N-isopropylacrylamide	175-181	phosphodiesterase 6A	Homo sapiens	168-172
21194703-6	2011	By taking advantage of the high pK(a) values of TA and PEAA, we were also able to construct multilayers of PDEA-b-PNIPAM micelles through hydrogen bonding interactions between micellar PNIPAM coronas and TA or PEAA.	Hydrogen	138-146	phosphodiesterase 6A	Homo sapiens	107-111
21194703-6	2011	By taking advantage of the high pK(a) values of TA and PEAA, we were also able to construct multilayers of PDEA-b-PNIPAM micelles through hydrogen bonding interactions between micellar PNIPAM coronas and TA or PEAA.	poly-N-isopropylacrylamide	114-120	phosphodiesterase 6A	Homo sapiens	107-111
20594406-3	2011	In comparison with the PDEA hydrogel, the equilibrium swelling ratio (ESR) and lower critical solution temperature (LCST) of the hydrogels increase with the increase of DMAEMA content in the feed.	2-(dimethylamino)ethyl methacrylate	169-175	phosphodiesterase 6A	Homo sapiens	23-27
20394380-1	2010	We report the effect of a range of monovalent sodium salts on the molecular equilibrium swelling of a simple synthetic microphase separated poly(methyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)-block-poly(methyl methacrylate) (PMMA(88)-b-PDEA(223)-b-PMMA(88)) pH-responsive hydrogel.	sodium salts	46-58	phosphodiesterase 6A	Homo sapiens	257-261
19928784-1	2010	The thermoresponsive behavior of the rhodamine B end-labeled double hydrophilic block copolymer (DHBC) poly(N,N-dimethylacrylamide)-b-poly(N,N-diethylacrylamide) (RhB-PDMA(207)-b-PDEA(177)) and the 1:1 segmental mixture of PDEA and rhodamine B end-labeled PDMA homopolymers was studied over the range of 10-40 degrees C at the air-water interface.	rhodamine B	37-48	phosphodiesterase 6A	Homo sapiens	179-183
19928784-1	2010	The thermoresponsive behavior of the rhodamine B end-labeled double hydrophilic block copolymer (DHBC) poly(N,N-dimethylacrylamide)-b-poly(N,N-diethylacrylamide) (RhB-PDMA(207)-b-PDEA(177)) and the 1:1 segmental mixture of PDEA and rhodamine B end-labeled PDMA homopolymers was studied over the range of 10-40 degrees C at the air-water interface.	rhodamine B	37-48	phosphodiesterase 6A	Homo sapiens	223-227
19928784-1	2010	The thermoresponsive behavior of the rhodamine B end-labeled double hydrophilic block copolymer (DHBC) poly(N,N-dimethylacrylamide)-b-poly(N,N-diethylacrylamide) (RhB-PDMA(207)-b-PDEA(177)) and the 1:1 segmental mixture of PDEA and rhodamine B end-labeled PDMA homopolymers was studied over the range of 10-40 degrees C at the air-water interface.	dhbc	97-101	phosphodiesterase 6A	Homo sapiens	179-183
19928784-1	2010	The thermoresponsive behavior of the rhodamine B end-labeled double hydrophilic block copolymer (DHBC) poly(N,N-dimethylacrylamide)-b-poly(N,N-diethylacrylamide) (RhB-PDMA(207)-b-PDEA(177)) and the 1:1 segmental mixture of PDEA and rhodamine B end-labeled PDMA homopolymers was studied over the range of 10-40 degrees C at the air-water interface.	dhbc	97-101	phosphodiesterase 6A	Homo sapiens	223-227
19928784-2	2010	The increase in collapse surface pressure (second plateau regime) of the DHBC with temperature confirms the thermoresponsiveness of PDEA at the interface.	dhbc	73-77	phosphodiesterase 6A	Homo sapiens	132-136
19928784-6	2010	The present results suggest that both the covalent bond between the two blocks of the DHBC and the tendency of rhodamine B to aggregate play a role in the formation of the bright cores at low temperature whereas PDEA thermoaggregation is responsible for the formation of the dark cores above the LCST of PDEA.	dhbc	86-90	phosphodiesterase 6A	Homo sapiens	212-216
19928784-6	2010	The present results suggest that both the covalent bond between the two blocks of the DHBC and the tendency of rhodamine B to aggregate play a role in the formation of the bright cores at low temperature whereas PDEA thermoaggregation is responsible for the formation of the dark cores above the LCST of PDEA.	dhbc	86-90	phosphodiesterase 6A	Homo sapiens	304-308
19928784-6	2010	The present results suggest that both the covalent bond between the two blocks of the DHBC and the tendency of rhodamine B to aggregate play a role in the formation of the bright cores at low temperature whereas PDEA thermoaggregation is responsible for the formation of the dark cores above the LCST of PDEA.	rhodamine B	111-122	phosphodiesterase 6A	Homo sapiens	304-308
19722630-5	2009	The triblock copolymer poly(ethylene oxide)(45)-block-polystyrene(130)-block-poly(2-diethylaminoethyl methacrylate)(120) (PEO(45)-b-PS(130)-b-PDEA(120)) was synthesized via ATRP.	block-poly(2-diethylaminoethyl methacrylate)	71-115	phosphodiesterase 6A	Homo sapiens	142-146
19722630-11	2009	The increase of the thickness of the intermediate PDEA layer arises from the protonation and hydration, but the swelling is constrained by the PS layers.	Phosphorus	143-145	phosphodiesterase 6A	Homo sapiens	50-54
19722630-12	2009	The increase of the thickness of the two PS layers is a result of an increasing incompatibility and an accompanying sharpening of the interface between the PS layers and the PDEA layer.	Phosphorus	41-43	phosphodiesterase 6A	Homo sapiens	174-178
19722630-12	2009	The increase of the thickness of the two PS layers is a result of an increasing incompatibility and an accompanying sharpening of the interface between the PS layers and the PDEA layer.	Phosphorus	156-158	phosphodiesterase 6A	Homo sapiens	174-178
19722630-13	2009	Starting at a pH slightly below 6, progressive swelling of the PDEA layer with decreasing pH induces a cracking of the two PS layers and also a sharp increase of the vesicle size and the wall thickness.	Phosphorus	123-125	phosphodiesterase 6A	Homo sapiens	63-67
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	Polyethylene Glycols	19-22	phosphodiesterase 6A	Homo sapiens	35-39
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	Polyethylene Glycols	19-22	phosphodiesterase 6A	Homo sapiens	153-157
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	-b-ptbma	23-31	phosphodiesterase 6A	Homo sapiens	35-39
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	-b-ptbma	23-31	phosphodiesterase 6A	Homo sapiens	153-157
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	terpolymers	54-65	phosphodiesterase 6A	Homo sapiens	35-39
19239225-6	2009	The preparation of PEG(-b-PtBMA)-b-PDEA miktoarm star terpolymers was then achieved via the click reaction of 4 with an excess of monoalkynyl-terminated PDEA.	terpolymers	54-65	phosphodiesterase 6A	Homo sapiens	153-157
19239225-7	2009	The obtained miktoarm star terpolymers were successfully converted into PEG(-b-PMAA)-b-PDEA, where PMAA is poly(methacrylic acid).	Polyethylene Glycols	72-75	phosphodiesterase 6A	Homo sapiens	87-91
19239225-7	2009	The obtained miktoarm star terpolymers were successfully converted into PEG(-b-PMAA)-b-PDEA, where PMAA is poly(methacrylic acid).	b-pmaa	77-83	phosphodiesterase 6A	Homo sapiens	87-91
19239225-7	2009	The obtained miktoarm star terpolymers were successfully converted into PEG(-b-PMAA)-b-PDEA, where PMAA is poly(methacrylic acid).	polymethacrylic acid	79-83	phosphodiesterase 6A	Homo sapiens	87-91
19239225-7	2009	The obtained miktoarm star terpolymers were successfully converted into PEG(-b-PMAA)-b-PDEA, where PMAA is poly(methacrylic acid).	polymethacrylic acid	107-129	phosphodiesterase 6A	Homo sapiens	87-91
19239225-8	2009	In aqueous solution, PEG(-b-PMAA)-b-PDEA zwitterionic ABC miktoarm star terpolymers can self-assemble into three types of micellar aggregates by simply adjusting solution pH at room temperature.	Polyethylene Glycols	21-24	phosphodiesterase 6A	Homo sapiens	36-40
19239225-8	2009	In aqueous solution, PEG(-b-PMAA)-b-PDEA zwitterionic ABC miktoarm star terpolymers can self-assemble into three types of micellar aggregates by simply adjusting solution pH at room temperature.	polymethacrylic acid	27-32	phosphodiesterase 6A	Homo sapiens	36-40
19239225-9	2009	Above pH 8, PDEA-core micelles stabilized by PEG/ionized PMAA hybrid coronas were formed due to the insolubility of PDEA block.	Polyethylene Glycols	45-48	phosphodiesterase 6A	Homo sapiens	12-16
19239225-11	2009	At pH<4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	Hydrogen	12-20	phosphodiesterase 6A	Homo sapiens	206-210
19239225-11	2009	At pH<4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	polymethacrylic acid	67-71	phosphodiesterase 6A	Homo sapiens	206-210
19239225-11	2009	At pH<4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	Polyethylene Glycols	76-79	phosphodiesterase 6A	Homo sapiens	206-210
19239225-11	2009	At pH<4, hydrogen bonding interactions between fully protonated PMAA and PEG led to the formation of another type of micellar aggregates possessing hydrogen-bonded complex cores stabilized by protonated PDEA coronas.	Hydrogen	151-159	phosphodiesterase 6A	Homo sapiens	206-210
19235799-1	2009	An effective and facile approach to prepare gold-nanoparticle-encapsulated alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodisperse hybrid nanospheres (ALG-PDEA-Au) is developed by using monodisperse ALG-PDEA nanospheres as a precursor nanoparticulate reaction system.	alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodisperse	75-141	phosphodiesterase 6A	Homo sapiens	166-170
19235799-1	2009	An effective and facile approach to prepare gold-nanoparticle-encapsulated alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodisperse hybrid nanospheres (ALG-PDEA-Au) is developed by using monodisperse ALG-PDEA nanospheres as a precursor nanoparticulate reaction system.	alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodisperse	75-141	phosphodiesterase 6A	Homo sapiens	214-218
19235799-4	2009	It is demonstrated that negatively charged ALG-PDEA-Au hybrid nanospheres can be internalized by human colorectal LoVo cancer cells and hence act as novel optical-contrast reagents in tumor-cell imaging by optical microscopy.	Gold	52-54	phosphodiesterase 6A	Homo sapiens	47-51
18954152-2	2008	Cationic, pH-responsive micelles of poly[2-(dimethylamino)ethyl methacrylate-block-poly(2-(diethylamino)ethyl methacrylate)] (PDMA-PDEA) were deposited on anionic polystyrene latex particles.	poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)	36-124	phosphodiesterase 6A	Homo sapiens	131-135
18954152-5	2008	It was found that subtle chemical modification of the PDMA-PDEA diblock copolymer via permanent quaternization of the PDEA block results in micelles with tunable loading capacities.	diblock copolymer	64-81	phosphodiesterase 6A	Homo sapiens	54-63
18954152-5	2008	It was found that subtle chemical modification of the PDMA-PDEA diblock copolymer via permanent quaternization of the PDEA block results in micelles with tunable loading capacities.	diblock copolymer	64-81	phosphodiesterase 6A	Homo sapiens	59-63
18954152-6	2008	Multilayers of cationic micelles of partially quaternized PDMA-PDEA and anionic polyelectrolyte (poly(sodium 4-styrene sulfonate)) were deposited on the surface of polystyrene latex particles by sequential adsorption.	Polystyrenes	164-175	phosphodiesterase 6A	Homo sapiens	63-67
18755475-3	2008	For the copolymer, the limiting area per segment versus temperature shows a break point around 29 degrees C, slightly lower than the lower critical solution temperature (LCST) of h-PDEA in water (31-33 degrees C).	copolymer	8-17	phosphodiesterase 6A	Homo sapiens	181-185
18755475-3	2008	For the copolymer, the limiting area per segment versus temperature shows a break point around 29 degrees C, slightly lower than the lower critical solution temperature (LCST) of h-PDEA in water (31-33 degrees C).	Water	189-194	phosphodiesterase 6A	Homo sapiens	181-185
18755475-6	2008	The PDcA(11) block, anchoring the polymer to the interface, ensures a better stability and cohesion to the film and preserves the thermo-sensitivity of the h-PDEA at the interface.	Polymers	34-41	phosphodiesterase 6A	Homo sapiens	158-162
18707086-1	2008	A series of well-defined poly(ethylene oxide)- b-poly(2-(diethylamino)ethyl methacrylate) (PEO- b-PDEA) diblock copolymers containing PEO block of identical chain length and PDEA block with varying degrees of polymerization (DP, in the range of 32-154) were prepared via atom transfer radical polymerization (ATRP) employing a PEO-based macroinitiator (DP = 113).	copolymers	112-122	phosphodiesterase 6A	Homo sapiens	98-102
18707086-2	2008	Upon a pH-jump from 3 to 12 under highly efficient stopped-flow mixing conditions, PEO- b-PDEA copolymers spontaneously form spherical micelles of increasing sizes and aggregation numbers ( N agg) with increasing PDEA chain lengths.	copolymers	95-105	phosphodiesterase 6A	Homo sapiens	90-94
18707086-2	2008	Upon a pH-jump from 3 to 12 under highly efficient stopped-flow mixing conditions, PEO- b-PDEA copolymers spontaneously form spherical micelles of increasing sizes and aggregation numbers ( N agg) with increasing PDEA chain lengths.	copolymers	95-105	phosphodiesterase 6A	Homo sapiens	213-217
18707086-7	2008	Upon increasing the DP of pH-responsive PDEA block to 89, 117, and 154, the obtained slow relaxation time, tau 2, tends to decrease with increasing polymer concentrations, suggesting that the slow process is dominated by the micelle fusion/fission mechanism.	dp	20-22	phosphodiesterase 6A	Homo sapiens	40-44
18707086-7	2008	Upon increasing the DP of pH-responsive PDEA block to 89, 117, and 154, the obtained slow relaxation time, tau 2, tends to decrease with increasing polymer concentrations, suggesting that the slow process is dominated by the micelle fusion/fission mechanism.	Polymers	148-155	phosphodiesterase 6A	Homo sapiens	40-44
18707086-9	2008	It was found that during micellization, copolymers with longer PDEA blocks exhibit much lower E a compared to those with shorter blocks.	copolymers	40-50	phosphodiesterase 6A	Homo sapiens	63-67
18620444-2	2008	Here, a pH-responsive copolymer, poly(2-(dimethylamino)ethyl methacrylate)- b-poly(2-(diethylamino)ethyl methacrylate) (PDMA(106)- b-PDEA(25)), has been used to study the formation and dissociation of adsorbed micelles through pH variation.	copolymer	22-31	phosphodiesterase 6A	Homo sapiens	133-137
18620444-2	2008	Here, a pH-responsive copolymer, poly(2-(dimethylamino)ethyl methacrylate)- b-poly(2-(diethylamino)ethyl methacrylate) (PDMA(106)- b-PDEA(25)), has been used to study the formation and dissociation of adsorbed micelles through pH variation.	poly(2-(dimethylamino)ethyl methacrylate)- b-poly(2-(diethylamino)ethyl methacrylate)	33-118	phosphodiesterase 6A	Homo sapiens	133-137
18376894-2	2008	The chemical structures of the NFHO-PDMA-b-PDEA and NFHO-PDEA-b-PDMA depended on the addition sequence of the two monomers and the feeding molar ratios of [DMA] to [DEA] during the polymerization process.	N-myristoyl-alaninol	37-40	phosphodiesterase 6A	Homo sapiens	43-47
18376894-8	2008	TEM analysis indicated that the NFHO-PDMA(30)-b-PDEA(10) diblock copolymers can self-assemble into the multicompartment micelles in aqueous solutions under basic conditions, in which the pH value is higher than the pKa values of both PDMA and PDEA homopolymers, while the NFHO-PDEA(10)-b-PDMA(30) diblock copolymers can form flowerlike micelles in basic aqueous solution.	diblock copolymers	57-75	phosphodiesterase 6A	Homo sapiens	48-52
18376894-8	2008	TEM analysis indicated that the NFHO-PDMA(30)-b-PDEA(10) diblock copolymers can self-assemble into the multicompartment micelles in aqueous solutions under basic conditions, in which the pH value is higher than the pKa values of both PDMA and PDEA homopolymers, while the NFHO-PDEA(10)-b-PDMA(30) diblock copolymers can form flowerlike micelles in basic aqueous solution.	diblock copolymers	57-75	phosphodiesterase 6A	Homo sapiens	243-247
18376894-8	2008	TEM analysis indicated that the NFHO-PDMA(30)-b-PDEA(10) diblock copolymers can self-assemble into the multicompartment micelles in aqueous solutions under basic conditions, in which the pH value is higher than the pKa values of both PDMA and PDEA homopolymers, while the NFHO-PDEA(10)-b-PDMA(30) diblock copolymers can form flowerlike micelles in basic aqueous solution.	diblock copolymers	57-75	phosphodiesterase 6A	Homo sapiens	243-247
17935731-2	2008	In acidic solution, this copolymer forms core-shell micelles with the neutral PMAA chains being located in the hydrophobic cores and the protonated PDEA chains forming the cationic micelle coronas.	copolymer	25-34	phosphodiesterase 6A	Homo sapiens	148-152
17935731-3	2008	In alkaline solution, the copolymer forms the analogous inverted micelles with anionic PMAA coronas and hydrophobic PDEA cores.	copolymer	26-35	phosphodiesterase 6A	Homo sapiens	116-120
17935731-6	2008	In alkaline solution, analysis of the adsorption data suggests a conformation for the adsorbed copolymers where one block projects normal to the solid/liquid interface; this layer consists of a hydrophobic PDEA anchor block adsorbed on the silica surface and an anionic PMAA buoy block extending into the solution phase.	copolymers	95-105	phosphodiesterase 6A	Homo sapiens	206-210
17610891-1	2007	The desorption and subsequent pH-responsive behavior of selectively quaternized poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate) (PDMA-PDEA) films at the silica/aqueous solution interface has been characterized.	poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)	80-168	phosphodiesterase 6A	Homo sapiens	175-179
17307196-1	2007	Emulsion copolymerization of poly(methacrylic acid) and poly(2-(diethylamino)ethyl methacrylate) (PMAA/PDEA) yielded pH-responsive polyampholyte microgels of 200-300 nm in diameter.	poly(2-(diethylamino)ethyl methacrylate)	56-96	phosphodiesterase 6A	Homo sapiens	103-107
17307196-1	2007	Emulsion copolymerization of poly(methacrylic acid) and poly(2-(diethylamino)ethyl methacrylate) (PMAA/PDEA) yielded pH-responsive polyampholyte microgels of 200-300 nm in diameter.	polyampholyte	131-144	phosphodiesterase 6A	Homo sapiens	103-107
17291037-1	2007	In this paper, alginic acid-poly(2-(diethylamino)ethyl methacrylate) (ALG-PDEA) nanoparticles were successfully prepared in aqueous medium using a polymer-monomer pair reaction system consisting of the anionic alginic acid (ALG) and the cationic 2-(diethylamino)ethyl methacrylate (DEA), without any aid of surfactants or organic solvents.	alginic acid-poly(2-(diethylamino)ethyl methacrylate)	15-68	phosphodiesterase 6A	Homo sapiens	74-78
17291037-1	2007	In this paper, alginic acid-poly(2-(diethylamino)ethyl methacrylate) (ALG-PDEA) nanoparticles were successfully prepared in aqueous medium using a polymer-monomer pair reaction system consisting of the anionic alginic acid (ALG) and the cationic 2-(diethylamino)ethyl methacrylate (DEA), without any aid of surfactants or organic solvents.	Polymers	147-154	phosphodiesterase 6A	Homo sapiens	74-78
17291037-1	2007	In this paper, alginic acid-poly(2-(diethylamino)ethyl methacrylate) (ALG-PDEA) nanoparticles were successfully prepared in aqueous medium using a polymer-monomer pair reaction system consisting of the anionic alginic acid (ALG) and the cationic 2-(diethylamino)ethyl methacrylate (DEA), without any aid of surfactants or organic solvents.	Alginic Acid	15-27	phosphodiesterase 6A	Homo sapiens	74-78
17291037-1	2007	In this paper, alginic acid-poly(2-(diethylamino)ethyl methacrylate) (ALG-PDEA) nanoparticles were successfully prepared in aqueous medium using a polymer-monomer pair reaction system consisting of the anionic alginic acid (ALG) and the cationic 2-(diethylamino)ethyl methacrylate (DEA), without any aid of surfactants or organic solvents.	Alginic Acid	70-73	phosphodiesterase 6A	Homo sapiens	74-78
17291037-1	2007	In this paper, alginic acid-poly(2-(diethylamino)ethyl methacrylate) (ALG-PDEA) nanoparticles were successfully prepared in aqueous medium using a polymer-monomer pair reaction system consisting of the anionic alginic acid (ALG) and the cationic 2-(diethylamino)ethyl methacrylate (DEA), without any aid of surfactants or organic solvents.	diethylaminoethyl methacrylate	33-67	phosphodiesterase 6A	Homo sapiens	74-78
17291037-5	2007	A pH-sensitive anticancer agent, hydroxycamptothecin (HCPT), was encapsulated in ALG-PDEA nanoparticles, and preliminary in vitro release as well as cytotoxicity experiments were carried out.	hydroxycamptothecinum	33-52	phosphodiesterase 6A	Homo sapiens	85-89
17291037-5	2007	A pH-sensitive anticancer agent, hydroxycamptothecin (HCPT), was encapsulated in ALG-PDEA nanoparticles, and preliminary in vitro release as well as cytotoxicity experiments were carried out.	hydroxycamptothecinum	54-58	phosphodiesterase 6A	Homo sapiens	85-89
17291037-5	2007	A pH-sensitive anticancer agent, hydroxycamptothecin (HCPT), was encapsulated in ALG-PDEA nanoparticles, and preliminary in vitro release as well as cytotoxicity experiments were carried out.	Alginic Acid	81-84	phosphodiesterase 6A	Homo sapiens	85-89
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	copolymer	50-59	phosphodiesterase 6A	Homo sapiens	71-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	copolymer	50-59	phosphodiesterase 6A	Homo sapiens	212-216
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	diethylaminoethyl methacrylate	116-150	phosphodiesterase 6A	Homo sapiens	71-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	atrp	161-165	phosphodiesterase 6A	Homo sapiens	71-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	2-Propanol	169-179	phosphodiesterase 6A	Homo sapiens	71-75
17241021-2	2007	Well-defined double hydrophilic miktoarm AB4 star copolymer, PNIPAM-b-(PDEA)4, was then synthesized by polymerizing 2-(diethylamino)ethyl methacrylate (DEA) via ATRP in 2-propanol at 45 degrees C using 1b, where PDEA was poly(2-(diethylamino)ethyl methacrylate).	poly(2-(diethylamino)ethyl methacrylate)	221-260	phosphodiesterase 6A	Homo sapiens	71-75
16930613-1	2006	The pH-responsive behavior of adsorbed diblock copolymer films of PDMA-PDEA (poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)) on silica has been characterized using a quartz crystal microbalance with dissipation monitoring (QCM-D), an optical reflectometer (OR) and an atomic force microscope (AFM).	copolymer	47-56	phosphodiesterase 6A	Homo sapiens	66-75
16930613-1	2006	The pH-responsive behavior of adsorbed diblock copolymer films of PDMA-PDEA (poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)) on silica has been characterized using a quartz crystal microbalance with dissipation monitoring (QCM-D), an optical reflectometer (OR) and an atomic force microscope (AFM).	poly(2-(dimethylamino)ethyl methacrylate)	77-117	phosphodiesterase 6A	Homo sapiens	66-75
16930613-1	2006	The pH-responsive behavior of adsorbed diblock copolymer films of PDMA-PDEA (poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)) on silica has been characterized using a quartz crystal microbalance with dissipation monitoring (QCM-D), an optical reflectometer (OR) and an atomic force microscope (AFM).	diethylaminoethyl methacrylate	132-165	phosphodiesterase 6A	Homo sapiens	66-75
16930613-1	2006	The pH-responsive behavior of adsorbed diblock copolymer films of PDMA-PDEA (poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)) on silica has been characterized using a quartz crystal microbalance with dissipation monitoring (QCM-D), an optical reflectometer (OR) and an atomic force microscope (AFM).	Silicon Dioxide	170-176	phosphodiesterase 6A	Homo sapiens	66-75
16869582-1	2006	The adsorption behavior of two examples of a weakly basic diblock copolymer, poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate) (PDMA-PDEA), at the silica/aqueous solution interface has been investigated using a quartz crystal microbalance with dissipation monitoring and an optical reflectometer.	poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)	77-165	phosphodiesterase 6A	Homo sapiens	172-176
16869582-4	2006	As a result, the adsorption behavior of PDMA-PDEA diblock copolymers on silica is strongly dependent on both the copolymer concentration and the solution pH.	copolymers	58-68	phosphodiesterase 6A	Homo sapiens	45-49
16869582-4	2006	As a result, the adsorption behavior of PDMA-PDEA diblock copolymers on silica is strongly dependent on both the copolymer concentration and the solution pH.	Silicon Dioxide	72-78	phosphodiesterase 6A	Homo sapiens	45-49
16869582-4	2006	As a result, the adsorption behavior of PDMA-PDEA diblock copolymers on silica is strongly dependent on both the copolymer concentration and the solution pH.	copolymer	58-67	phosphodiesterase 6A	Homo sapiens	45-49
16869582-5	2006	Below the cmc at pH 9, the cationic PDMA-PDEA copolymers adsorb as unimers and the conformation of the adsorbed polymer is essentially flat.	copolymers	46-56	phosphodiesterase 6A	Homo sapiens	41-45
16732660-1	2006	The similarities and differences in the adsorption behavior of diblock poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate) (XqPDMA-PDEA, where X refers to a mean degree of quaternization of the PDMA of either 0, 10, 50, or 100 mol%) copolymers at the mica/ and silica/aqueous solution interfaces have been investigated.	diblock poly(2-(dimethylamino)ethyl methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate)	63-155	phosphodiesterase 6A	Homo sapiens	164-168
16732660-2	2006	These diblock copolymers form core-shell micelles with the PDEA chains located in the cores and the more hydrophilic PDMA chains forming the cationic micelle coronas at pH 9.	diblock copolymers	6-24	phosphodiesterase 6A	Homo sapiens	59-63
16732660-5	2006	In particular, the morphology of the adsorbed nonquaternized 0qPDMA-PDEA copolymer micelles is clearly influenced by the substrate type: these micelles form a disordered layer on silica, while much more close-packed, highly ordered layers are obtained on mica.	Silicon Dioxide	179-185	phosphodiesterase 6A	Homo sapiens	68-72
16732660-5	2006	In particular, the morphology of the adsorbed nonquaternized 0qPDMA-PDEA copolymer micelles is clearly influenced by the substrate type: these micelles form a disordered layer on silica, while much more close-packed, highly ordered layers are obtained on mica.	mica	255-259	phosphodiesterase 6A	Homo sapiens	68-72
15658775-1	2005	Selectively quaternising the PDMA block of poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate) (PDMA-PDEA) copolymers modifies both their solution and adsorption behaviour.	poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate)	43-131	phosphodiesterase 6A	Homo sapiens	138-142
15629837-16	2005	Excess of PDEgamma may affect normal cone cGMP-PDE function by inhibiting the catalytic PDEalpha,beta activity and lead to pathogenic elevation of cGMP and eventual degeneration of cone photoreceptors.	Cyclic GMP	42-46	phosphodiesterase 6A	Homo sapiens	88-96
11900530-6	2002	The site of Pgamma-21-45 cross-linking was localized to Met138Gly139 within the PDE6alpha GAFa domain using mass spectrometric analysis.	pgamma-21	12-21	phosphodiesterase 6A	Homo sapiens	80-89
11900530-6	2002	The site of Pgamma-21-45 cross-linking was localized to Met138Gly139 within the PDE6alpha GAFa domain using mass spectrometric analysis.	met138gly139	56-68	phosphodiesterase 6A	Homo sapiens	80-89
11900530-7	2002	Chimeras between PDE5 and cone PDE6alpha", containing GAFa and/or GAFb domains of PDE6alpha" have been generated to probe a potential role of the GAFb domains in binding to Pgamma.	gafa	54-58	phosphodiesterase 6A	Homo sapiens	31-40
11285263-7	2001	Our mutational analysis of chimeric PDE5/PDE6alpha" enzymes revealed that the inhibitory interaction of cone PDE6 catalytic subunits (PDE6alpha") with Pgamma is mediated primarily by three hydrophobic residues at the entry to the catalytic pocket, Met(758), Phe(777), and Phe(781).	Phenylalanine	258-261	phosphodiesterase 6A	Homo sapiens	41-50
11285263-7	2001	Our mutational analysis of chimeric PDE5/PDE6alpha" enzymes revealed that the inhibitory interaction of cone PDE6 catalytic subunits (PDE6alpha") with Pgamma is mediated primarily by three hydrophobic residues at the entry to the catalytic pocket, Met(758), Phe(777), and Phe(781).	Phenylalanine	258-261	phosphodiesterase 6A	Homo sapiens	134-143
11285263-7	2001	Our mutational analysis of chimeric PDE5/PDE6alpha" enzymes revealed that the inhibitory interaction of cone PDE6 catalytic subunits (PDE6alpha") with Pgamma is mediated primarily by three hydrophobic residues at the entry to the catalytic pocket, Met(758), Phe(777), and Phe(781).	Phenylalanine	272-275	phosphodiesterase 6A	Homo sapiens	41-50
11285263-7	2001	Our mutational analysis of chimeric PDE5/PDE6alpha" enzymes revealed that the inhibitory interaction of cone PDE6 catalytic subunits (PDE6alpha") with Pgamma is mediated primarily by three hydrophobic residues at the entry to the catalytic pocket, Met(758), Phe(777), and Phe(781).	Phenylalanine	272-275	phosphodiesterase 6A	Homo sapiens	134-143
10725092-5	2000	Alternatively, commercial Cy5 succinimidyl ester was reacted with a primary amine (MTSEA, methanethiosulfonylethylamine, or PDEA, pyridyldithioethylamine) or a secondary amine (PEM, piperazinylethylmaleimide) to give the corresponding thiol-reactive derivatives in a single step.	cy5 succinimidyl ester	26-48	phosphodiesterase 6A	Homo sapiens	124-128
10393062-1	1999	PURPOSE: To determine the mutation spectrum of the PDE6A gene encoding the alpha subunit of rod cyclic guanosine monophosphate (cGMP)phosphodiesterase and the proportion of patients with recessive retinitis pigmentosa (RP) due to mutations in this gene.	Cyclic GMP	96-126	phosphodiesterase 6A	Homo sapiens	51-56
10393062-1	1999	PURPOSE: To determine the mutation spectrum of the PDE6A gene encoding the alpha subunit of rod cyclic guanosine monophosphate (cGMP)phosphodiesterase and the proportion of patients with recessive retinitis pigmentosa (RP) due to mutations in this gene.	Cyclic GMP	128-132	phosphodiesterase 6A	Homo sapiens	51-56
10393062-9	1999	A compilation of the pathogenic mutations in PDE6A and those reported in the homologous gene PDE6B encoding the beta subunit of rod cGMP-phosphodiesterase shows that the cGMP-binding and catalytic domains are frequently affected.	Cyclic GMP	132-136	phosphodiesterase 6A	Homo sapiens	45-50
8799503-3	1996	Polymer densities, determined by centrifugation in a density gradient, range from 1.10 for pDEA to 1.13 for p(DEA/MMA) 52/48 mol%.	Polymers	0-7	phosphodiesterase 6A	Homo sapiens	91-95
8415703-4	1993	PDE alpha and PDE beta exhibited the expected mobility (and thus apparent molecular size) and had cGMP hydrolytic activity.	Cyclic GMP	98-102	phosphodiesterase 6A	Homo sapiens	0-9
1328188-5	1992	Complexes of PDE alpha (PDE beta) with 1 and 2 molecules of activator G alpha GTP gamma S are observed, providing direct evidence for an interaction or at least a close proximity between 2 molecules of activator G alpha and each of the catalytic PDE subunits in the activated state of PDE.	Guanosine Triphosphate	78-81	phosphodiesterase 6A	Homo sapiens	13-22
1662493-4	1991	The following peptides exhibited a decreased ability to inhibit PDE alpha/beta: All were from PDE gamma # 63-87; PDE gamma Tyr 84----Gly, PDE gamma Phe 73----Gly and PDE gamma Gln 83----Gly.	Tyrosine	123-126	phosphodiesterase 6A	Homo sapiens	64-73
1659809-5	1991	The following mutants exhibited a decreased ability to inhibit PDE alpha/beta: Tyr84----Gly; Arg24----Gly; and Arg33----Pro.	Glycine	88-91	phosphodiesterase 6A	Homo sapiens	63-72
1653243-3	1991	Synthetic peptides corresponding to residues 16-30, 78-90, 389-403, and 535-563 of PDE alpha used in a PDE activity assay with trypsin-activated PDE partially prevented inhibition by exogenous PDE gamma; however, only competitions by peptides 16-30 and 78-90 (corresponding to PDE alpha 16-30 and 78-90) were concentration-dependent below 100 nmol of peptide.	Peptides	10-18	phosphodiesterase 6A	Homo sapiens	83-92
1653243-3	1991	Synthetic peptides corresponding to residues 16-30, 78-90, 389-403, and 535-563 of PDE alpha used in a PDE activity assay with trypsin-activated PDE partially prevented inhibition by exogenous PDE gamma; however, only competitions by peptides 16-30 and 78-90 (corresponding to PDE alpha 16-30 and 78-90) were concentration-dependent below 100 nmol of peptide.	Peptides	10-18	phosphodiesterase 6A	Homo sapiens	277-286
1653243-3	1991	Synthetic peptides corresponding to residues 16-30, 78-90, 389-403, and 535-563 of PDE alpha used in a PDE activity assay with trypsin-activated PDE partially prevented inhibition by exogenous PDE gamma; however, only competitions by peptides 16-30 and 78-90 (corresponding to PDE alpha 16-30 and 78-90) were concentration-dependent below 100 nmol of peptide.	Peptides	234-242	phosphodiesterase 6A	Homo sapiens	83-92
34612439-0	2021	DPD simulations on mixed polymeric DOX-loaded micelles assembled from PCL-SS-PPEGMA/PDEA-PPEGMA and their dual pH/reduction-responsive release.	Doxorubicin	35-38	phosphodiesterase 6A	Homo sapiens	84-88
24271344-2	1976	PDEA can be released from the membranes by a cAMP-dependent phosphorylation of a protein that may function as PDEA binding site (13).	Cyclic AMP	45-49	phosphodiesterase 6A	Homo sapiens	0-4
24271344-2	1976	PDEA can be released from the membranes by a cAMP-dependent phosphorylation of a protein that may function as PDEA binding site (13).	Cyclic AMP	45-49	phosphodiesterase 6A	Homo sapiens	110-114
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Norepinephrine	76-90	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Dopamine	92-100	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Adenosine	102-111	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Histamine	117-126	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Adenosine Triphosphate	146-149	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Cyclic AMP	165-169	phosphodiesterase 6A	Homo sapiens	14-18
24271344-3	1976	We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM.	Serotonin	219-228	phosphodiesterase 6A	Homo sapiens	14-18
24271344-4	1976	Norepinephrine and dopamine activate the adenylate cyclase activity of those preparations from which they release the PDEA.	Norepinephrine	0-14	phosphodiesterase 6A	Homo sapiens	118-122
24271344-4	1976	Norepinephrine and dopamine activate the adenylate cyclase activity of those preparations from which they release the PDEA.	Dopamine	19-27	phosphodiesterase 6A	Homo sapiens	118-122
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Norepinephrine	0-14	phosphodiesterase 6A	Homo sapiens	57-61
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Dopamine	35-43	phosphodiesterase 6A	Homo sapiens	57-61
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Dopamine	115-123	phosphodiesterase 6A	Homo sapiens	172-176
24271344-5	1976	Norepinephrine is more potent than dopamine in releasing PDEA from the particulate fraction of cerebellum, whereas dopamine is more active than norepinephrine in releasing PDEA from the particulate fraction of striatum.	Norepinephrine	144-158	phosphodiesterase 6A	Homo sapiens	172-176
15421-2	1976	The release of PDEA into cytosol where the activator-sensitive PDE is located, is the first event in the process of the regulation of cAMP metabolism and inactivation.	Cyclic AMP	134-138	phosphodiesterase 6A	Homo sapiens	15-19
15421-3	1976	PDEA is released by cAMP-dependent phosphorylation of the activator-binding sites.	Cyclic AMP	20-24	phosphodiesterase 6A	Homo sapiens	0-4
15421-7	1976	PDEA regulates cAMP metabolism when the concentration of cAMP is elevated by a transsynaptic activation of adenylate cyclase.	Cyclic AMP	15-19	phosphodiesterase 6A	Homo sapiens	0-4
15421-7	1976	PDEA regulates cAMP metabolism when the concentration of cAMP is elevated by a transsynaptic activation of adenylate cyclase.	Cyclic AMP	57-61	phosphodiesterase 6A	Homo sapiens	0-4
34057927-0	2021	P.arg102ser is a common Pde6a mutation causing autosomal recessive retinitis pigmentosa in Pakistani families.	arg102ser	2-11	phosphodiesterase 6A	Homo sapiens	24-29
32429371-2	2020	Linear copolymer P(DEA-co-IAM) was introduced into a solution of DEA monomer to prepare pH-thermo dual responsive P(DEA-co-IAM)/PDEA semi-IPN hydrogels.	copolymer p	7-18	phosphodiesterase 6A	Homo sapiens	128-132
32429371-2	2020	Linear copolymer P(DEA-co-IAM) was introduced into a solution of DEA monomer to prepare pH-thermo dual responsive P(DEA-co-IAM)/PDEA semi-IPN hydrogels.	dea-co-iam	19-29	phosphodiesterase 6A	Homo sapiens	128-132
32429371-2	2020	Linear copolymer P(DEA-co-IAM) was introduced into a solution of DEA monomer to prepare pH-thermo dual responsive P(DEA-co-IAM)/PDEA semi-IPN hydrogels.	dea	19-22	phosphodiesterase 6A	Homo sapiens	128-132
31977226-3	2020	T micelles formed by poly(epsilon-caprolactone)-b-poly(N,N-diethylaminoethyl methacrylate)-ss-b-poly(2-methacryloyloxyethyl phosphorylcholine) (PCL-PDEA-ss-PMPC) turned their zeta-potentials from +1 mV to +18mV under treatment of 20 mM VC, while the zeta-potentials of control R micelles formed by PCL-ss-P(DEA-r-MPC) almost remained unchanged under the same condition.	poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone)	21-90	phosphodiesterase 6A	Homo sapiens	148-152
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	63-69	phosphodiesterase 6A	Homo sapiens	98-106
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	63-69	phosphodiesterase 6A	Homo sapiens	110-117
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	63-69	phosphodiesterase 6A	Homo sapiens	180-188
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	63-69	phosphodiesterase 6A	Homo sapiens	192-199
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	234-240	phosphodiesterase 6A	Homo sapiens	98-106
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	234-240	phosphodiesterase 6A	Homo sapiens	110-117
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	234-240	phosphodiesterase 6A	Homo sapiens	180-188
31076603-5	2019	However, recent structural analysis showed that the binding of Talpha* to PDEgamma still bound to PDEalpha or PDEbeta seems to be difficult because the binding site of PDEgamma to PDEalpha or PDEbeta overlaps with the binding site to Talpha*.	talpha	234-240	phosphodiesterase 6A	Homo sapiens	192-199
30297654-3	2018	The control experiments showed that the pH-responsive property of the system could be ascribed to the drug components of the solutions, whereas the thermal-, salt- and methanol-sensitive behaviors were attributed to the PDEA constituent of the films.	Methanol	168-176	phosphodiesterase 6A	Homo sapiens	220-224
29924440-1	2018	ABC triblock copolymer assemblies with reversible "breathing" behaviors based on poly[oligo(ethylene glycol) methyl ether methacrylate]-b-poly(benzyl methacrylate)-b-poly[2-(diethylamino)ethyl methacrylate] (POEGMA-b-PBnMA-b-PDEA) are fabricated via one-pot sequential reverisble addition-fragmentation chain transfer dispersion polymerization.	abc triblock copolymer	0-22	phosphodiesterase 6A	Homo sapiens	225-229
29924440-2	2018	Using a POEGMA as the macromolecular chain transfer agent, chain extension with BnMA and DEA is conducted in ethanol, where PBnMA acts as the core-forming block, and the PDEA block endows the solvophilicity and CO2 -responsiveness.	poegma	8-14	phosphodiesterase 6A	Homo sapiens	170-174
29924440-2	2018	Using a POEGMA as the macromolecular chain transfer agent, chain extension with BnMA and DEA is conducted in ethanol, where PBnMA acts as the core-forming block, and the PDEA block endows the solvophilicity and CO2 -responsiveness.	bnma	80-84	phosphodiesterase 6A	Homo sapiens	170-174
29924440-2	2018	Using a POEGMA as the macromolecular chain transfer agent, chain extension with BnMA and DEA is conducted in ethanol, where PBnMA acts as the core-forming block, and the PDEA block endows the solvophilicity and CO2 -responsiveness.	dea	89-92	phosphodiesterase 6A	Homo sapiens	170-174
29924440-2	2018	Using a POEGMA as the macromolecular chain transfer agent, chain extension with BnMA and DEA is conducted in ethanol, where PBnMA acts as the core-forming block, and the PDEA block endows the solvophilicity and CO2 -responsiveness.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	211-214	phosphodiesterase 6A	Homo sapiens	170-174
29924440-3	2018	With the increment of the DP of PBnMA, the morphology of the assemblies evolves from spheres to worms, and to vesicles, while it degenerates from conglutinated vesicles to spheres as the DP of PDEA increases.	dp	26-28	phosphodiesterase 6A	Homo sapiens	193-197
29924440-3	2018	With the increment of the DP of PBnMA, the morphology of the assemblies evolves from spheres to worms, and to vesicles, while it degenerates from conglutinated vesicles to spheres as the DP of PDEA increases.	pbnma	32-37	phosphodiesterase 6A	Homo sapiens	193-197
29924440-3	2018	With the increment of the DP of PBnMA, the morphology of the assemblies evolves from spheres to worms, and to vesicles, while it degenerates from conglutinated vesicles to spheres as the DP of PDEA increases.	dp	187-189	phosphodiesterase 6A	Homo sapiens	193-197
29924440-4	2018	After replacing ethanol with water, the morphologies of these assemblies remain unchanged, while their size decreases due to the collapse of the hydrophobic PDEA chains.	Ethanol	16-23	phosphodiesterase 6A	Homo sapiens	157-161
29924440-4	2018	After replacing ethanol with water, the morphologies of these assemblies remain unchanged, while their size decreases due to the collapse of the hydrophobic PDEA chains.	Water	29-34	phosphodiesterase 6A	Homo sapiens	157-161
29924440-5	2018	Interestingly, due to the protonation and deprotonation of PDEA blocks, both the spheres and vesicles manifest a reversible expansion/shrinkage upon alternative CO2 /Ar stimulation, exhibiting distinctive breathing feature.	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	161-164	phosphodiesterase 6A	Homo sapiens	59-63
29924440-5	2018	Interestingly, due to the protonation and deprotonation of PDEA blocks, both the spheres and vesicles manifest a reversible expansion/shrinkage upon alternative CO2 /Ar stimulation, exhibiting distinctive breathing feature.	Argon	166-168	phosphodiesterase 6A	Homo sapiens	59-63
29212382-12	2017	There were several indications of improved retinal health in the PDE6A expressing regions including lack of abnormal cyclic GMP accumulation, appropriate rod opsin localization to the outer segments with a large reduction in mislocalization to other regions of the rod cell, and reduced Muller cell activation.	Cyclic GMP	117-127	phosphodiesterase 6A	Homo sapiens	65-70
28778054-4	2017	A triblock amphiphilic copolymer, methoxy-poly(ethylene glycol) 2000-poly(2-(N,N-diethylamino)ethyl methacrylate)-polycaprolactone (mPEG-PDEA-PCL, PDC), was used to load paclitaxel (PTX), a hydrophobic anticancer agent, using an injection method.	copolymer	23-32	phosphodiesterase 6A	Homo sapiens	137-141
28778054-4	2017	A triblock amphiphilic copolymer, methoxy-poly(ethylene glycol) 2000-poly(2-(N,N-diethylamino)ethyl methacrylate)-polycaprolactone (mPEG-PDEA-PCL, PDC), was used to load paclitaxel (PTX), a hydrophobic anticancer agent, using an injection method.	methoxy-poly(ethylene glycol) 2000-poly(2-(n,n-diethylamino)ethyl methacrylate)-polycaprolactone	34-130	phosphodiesterase 6A	Homo sapiens	137-141
28778054-8	2017	The pH-responsive segment, PDEA, transforms to its protonated form, PDEAH+, in an acidic environment.	pdeah+	68-74	phosphodiesterase 6A	Homo sapiens	27-31
28778054-9	2017	PTX and PDC form micelles based on hydrophobic interactions, where PTX inserts into the hydrophobic PDEA-PCL core in a neutral environment.	Paclitaxel	0-3	phosphodiesterase 6A	Homo sapiens	100-104
28778054-9	2017	PTX and PDC form micelles based on hydrophobic interactions, where PTX inserts into the hydrophobic PDEA-PCL core in a neutral environment.	Paclitaxel	67-70	phosphodiesterase 6A	Homo sapiens	100-104
28778054-10	2017	An acidic transition of the environment leads to rapid PTX release from the micelles due to the hydrophobic-hydrophilic transition of PDEA to PDEAH+, though some PTX molecules still remain in the PCL core.	Paclitaxel	55-58	phosphodiesterase 6A	Homo sapiens	134-138
28384619-0	2017	pH responsive micelles based on copolymers mPEG-PCL-PDEA: The relationship between composition and properties.	copolymers	32-42	phosphodiesterase 6A	Homo sapiens	52-56
28384619-0	2017	pH responsive micelles based on copolymers mPEG-PCL-PDEA: The relationship between composition and properties.	methoxy poly(ethylene glycol-co-epsilon-caprolactone)	43-51	phosphodiesterase 6A	Homo sapiens	52-56
28384619-2	2017	In this study, copolymers methoxy-poly (ethylene glycol)-b-poly (epsilon-caprolactone)-b-poly (diethylaminoethyl methacrylate) (mPEG-PCL-PDEA) were designed and synthesized to investigate the relationship between number of pH responsive units and micelle properties.	copolymers	15-25	phosphodiesterase 6A	Homo sapiens	137-141
28384619-6	2017	The results showed that the micelle properties including pH sensitivity, cytotoxicity and drug loading/releasing performance, were related to PDEA units in copolymers.	copolymers	156-166	phosphodiesterase 6A	Homo sapiens	142-146
28119221-6	2017	As the mole concentration of copolymer is increased from 10% to 50%, the microstructures formed by PCL-PDEA-PSBMA and DOX remains spherical micelles whereas PCL-PDEA-PEGMA undergoes structural transition from spherical to cylindrical and finally to lamellar micelles.	copolymer	29-38	phosphodiesterase 6A	Homo sapiens	103-107
28119221-6	2017	As the mole concentration of copolymer is increased from 10% to 50%, the microstructures formed by PCL-PDEA-PSBMA and DOX remains spherical micelles whereas PCL-PDEA-PEGMA undergoes structural transition from spherical to cylindrical and finally to lamellar micelles.	copolymer	29-38	phosphodiesterase 6A	Homo sapiens	161-165
27820873-0	2016	Increased Plasma cGMP in a Family With Autosomal Recessive Retinitis Pigmentosa Due to Homozygous Mutations in the PDE6A Gene.	Cyclic GMP	17-21	phosphodiesterase 6A	Homo sapiens	115-120
27820873-1	2016	Purpose: To describe genotype and phenotype in a family with autosomal recessive retinitis pigmentosa (arRP) carrying homozygous mutations in the gene for the alpha-subunit of cyclic guanosine monophosphate (cGMP)-hydrolyzing phosphodiesterase 6 (PDE6A).	Cyclic GMP	176-206	phosphodiesterase 6A	Homo sapiens	247-252
33429519-3	2015	A four-armed star copolymer, tetra-(methoxy-poly(ethylene glycol)-poly(2-(N,N-diethylamino)ethyl methacrylate)-poly(epsilon-caprolactone) pentaerythritol ((mPEG-pDEA-PCL)4-PET, PDCP), was synthesized via the ring-opening polymerization, atom transfer radical polymerization and click chemistry, which formed a monomolecular nanocarrier in water.	copolymer	18-27	phosphodiesterase 6A	Homo sapiens	161-165
25531063-6	2015	Results of in vitro cell toxicity evaluation showed that introduction of sulfobetaines could greatly decrease the toxicity of poly(e-caprolactone)-SS-poly(N,N-diethylaminoethyl methacrylate) (PCL-SS-PDEA) micelles.	sulfobetaine	73-86	phosphodiesterase 6A	Homo sapiens	199-203
25531063-6	2015	Results of in vitro cell toxicity evaluation showed that introduction of sulfobetaines could greatly decrease the toxicity of poly(e-caprolactone)-SS-poly(N,N-diethylaminoethyl methacrylate) (PCL-SS-PDEA) micelles.	poly(e-caprolactone)-ss-poly(n,n-diethylaminoethyl methacrylate)	126-190	phosphodiesterase 6A	Homo sapiens	199-203
24874300-5	2014	Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this.	Hydrogen	81-89	phosphodiesterase 6A	Homo sapiens	106-110
24874300-5	2014	Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this.	polymethacrylic acid	115-119	phosphodiesterase 6A	Homo sapiens	106-110
24874300-5	2014	Specifically, the synergistic effect of temperature and pH was observed, and the hydrogen bonding between PDEA and PMAA components in the copolymer played a key role for this.	copolymer	138-147	phosphodiesterase 6A	Homo sapiens	106-110
24936159-1	2014	Amphiphilic A2(BC)2 miktoarm star polymers [poly(epsilon-caprolactone)]2-[poly(2-(diethylamino)ethyl methacrylate)-b- poly(poly(ethylene glycol) methyl ether methacrylate)]2 [(PCL)2(PDEA-b-PPEGMA)2] were developed by a combination of ring opening polymerization (ROP) and continuous activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP).	Polymers	34-42	phosphodiesterase 6A	Homo sapiens	182-186
24440420-2	2014	Here, we report on reduction- and pH--sensitive crosslinked polymersomes based on the poly(ethylene glycol)-poly(acrylic acid)-poly(2-(diethyl amino)ethyl methacrylate) (PEG-PAA-PDEA) triblock copolymer for efficient intracellular delivery of proteins and the potent induction of cancer cell apoptosis.	poly(ethylene glycol)-poly(acrylic acid)-poly(2-(diethyl amino)ethyl methacrylate)	86-168	phosphodiesterase 6A	Homo sapiens	178-182
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	Cysteamine	156-166	phosphodiesterase 6A	Homo sapiens	8-12
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	Sulfhydryl Compounds	180-185	phosphodiesterase 6A	Homo sapiens	8-12
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	Sulfhydryl Compounds	180-185	phosphodiesterase 6A	Homo sapiens	209-213
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	peg-paa	0-7	phosphodiesterase 6A	Homo sapiens	8-12
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	peg-paa	0-7	phosphodiesterase 6A	Homo sapiens	209-213
24440420-4	2014	PEG-PAA(SH)-PDEA was water-soluble at acidic and physiological pH but formed robust and monodisperse polymersomes with an average size of ~35nm upon increasing the pH to 7.8 or above followed by oxidative crosslinking.	peg-paa	0-7	phosphodiesterase 6A	Homo sapiens	12-16
24440420-4	2014	PEG-PAA(SH)-PDEA was water-soluble at acidic and physiological pH but formed robust and monodisperse polymersomes with an average size of ~35nm upon increasing the pH to 7.8 or above followed by oxidative crosslinking.	Water	21-26	phosphodiesterase 6A	Homo sapiens	12-16
24588749-2	2014	Scanning electron microscopy studies indicated that flocs of the PDEA-PS particles were adsorbed at the surface of these water droplets, leading to stable spherical liquid marbles.	Water	121-126	phosphodiesterase 6A	Homo sapiens	65-69
24588749-5	2014	The liquid marbles can be transformed into polymeric capsules containing water by exposure to solvent vapor: the PDEA-PS particles were plasticized with the solvent vapor to form a polymer film at the air-water interface of the liquid marbles.	Water	73-78	phosphodiesterase 6A	Homo sapiens	113-117
24588749-5	2014	The liquid marbles can be transformed into polymeric capsules containing water by exposure to solvent vapor: the PDEA-PS particles were plasticized with the solvent vapor to form a polymer film at the air-water interface of the liquid marbles.	Polymers	43-50	phosphodiesterase 6A	Homo sapiens	113-117
24588749-5	2014	The liquid marbles can be transformed into polymeric capsules containing water by exposure to solvent vapor: the PDEA-PS particles were plasticized with the solvent vapor to form a polymer film at the air-water interface of the liquid marbles.	Water	205-210	phosphodiesterase 6A	Homo sapiens	113-117