PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
21055793-8	2010	PAR1-AP induced two-fold increase in CK2 activity and stimulated the translocation of CK2 from Triton X-100-soluble to -insoluble fraction.	Octoxynol	95-107	microtubule affinity regulating kinase 2	Homo sapiens	0-4
21055793-9	2010	Preincubation of platelets with the PI 3-kinase inhibitor, wortmannin or LY294002, impaired PAR1-AP-induced aggregation of platelets.	Wortmannin	59-69	microtubule affinity regulating kinase 2	Homo sapiens	92-96
21055793-9	2010	Preincubation of platelets with the PI 3-kinase inhibitor, wortmannin or LY294002, impaired PAR1-AP-induced aggregation of platelets.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	73-81	microtubule affinity regulating kinase 2	Homo sapiens	92-96
18546197-2	2009	METHODS: The alloy NPGtrade mark+2 with the nominal composition Cu:77.3; Al:7.8; Ni:4.3; Fe:3.0; Zn:2.7; Au:2.0; and Mn:1.7 was characterized.	Copper	64-66	microtubule affinity regulating kinase 2	Homo sapiens	28-34
20361941-4	2010	We identified nine genes (NAPA, CITED2, CABIN1, ADM, HIST1H1A, EHD1, MARK2, PTPN21, and MVD), which were consistently upregulated in two cisplatin-resistant HeLa cell lines.	Cisplatin	137-146	microtubule affinity regulating kinase 2	Homo sapiens	69-74
19098422-2	2008	Recent genetic and cell biological evidence points to a role for MAP/microtubule affinity-regulating kinase 2 (MARK2/EMK/Par1b) in the regulation of metabolic events as well as in the control of CREB-dependent transcription activated by glucose in pancreatic islet beta cells.	Glucose	237-244	microtubule affinity regulating kinase 2	Homo sapiens	65-109
19098422-2	2008	Recent genetic and cell biological evidence points to a role for MAP/microtubule affinity-regulating kinase 2 (MARK2/EMK/Par1b) in the regulation of metabolic events as well as in the control of CREB-dependent transcription activated by glucose in pancreatic islet beta cells.	Glucose	237-244	microtubule affinity regulating kinase 2	Homo sapiens	111-116
19098422-2	2008	Recent genetic and cell biological evidence points to a role for MAP/microtubule affinity-regulating kinase 2 (MARK2/EMK/Par1b) in the regulation of metabolic events as well as in the control of CREB-dependent transcription activated by glucose in pancreatic islet beta cells.	Glucose	237-244	microtubule affinity regulating kinase 2	Homo sapiens	121-126
19098422-4	2008	Application of this technology led us to identify MARK2 as the kinase that targets a novel glucose-regulated phosphorylation site on Transducer of Regulated CREB Activity 2 (TORC2, referred to as CREB-Regulated Transcriptional Coactivator 2, or CRTC2), a transcriptional coactivator essential for CREB activity in beta cells.	Glucose	91-98	microtubule affinity regulating kinase 2	Homo sapiens	50-55
19011111-3	2008	Previously, we demonstrated that atypical protein kinase C (aPKC) phosphorylates the Par-1 kinases on a conserved threonine residue (T595) to regulate localization and kinase activity.	Threonine	114-123	microtubule affinity regulating kinase 2	Homo sapiens	85-90
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	26-32
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	263-269
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	186-217	microtubule affinity regulating kinase 2	Homo sapiens	26-31
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	219-222	microtubule affinity regulating kinase 2	Homo sapiens	26-32
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Tetradecanoylphorbol Acetate	219-222	microtubule affinity regulating kinase 2	Homo sapiens	26-31
15324659-6	2004	On the other hand, aPKC phosphorylates threonine 595 of PAR-1b and enhances its binding with 14-3-3/PAR-5.	Threonine	39-48	microtubule affinity regulating kinase 2	Homo sapiens	56-62
18424437-3	2008	MARK family kinases can be activated by phosphorylation of a conserved threonine (Thr-208 in MARK2), and inactivated by phosphorylation of a serine (Ser-212), both in the activation loop of the catalytic domain.	Threonine	82-85	microtubule affinity regulating kinase 2	Homo sapiens	93-98
16257959-6	2005	Our further findings led us to conclude that GSK-3beta phosphorylates MARK2 on Ser-212, one of the two reported phosphorylation sites (Thr-208 and Ser-212) found in the activation loop of MARK2.	Serine	79-82	microtubule affinity regulating kinase 2	Homo sapiens	188-193
16257959-6	2005	Our further findings led us to conclude that GSK-3beta phosphorylates MARK2 on Ser-212, one of the two reported phosphorylation sites (Thr-208 and Ser-212) found in the activation loop of MARK2.	Threonine	135-138	microtubule affinity regulating kinase 2	Homo sapiens	70-75
16257959-6	2005	Our further findings led us to conclude that GSK-3beta phosphorylates MARK2 on Ser-212, one of the two reported phosphorylation sites (Thr-208 and Ser-212) found in the activation loop of MARK2.	Threonine	135-138	microtubule affinity regulating kinase 2	Homo sapiens	188-193
16257959-6	2005	Our further findings led us to conclude that GSK-3beta phosphorylates MARK2 on Ser-212, one of the two reported phosphorylation sites (Thr-208 and Ser-212) found in the activation loop of MARK2.	Serine	147-150	microtubule affinity regulating kinase 2	Homo sapiens	70-75
16257959-7	2005	Down-regulation of either GSK-3beta or MARK2 by small interfering RNAs suppressed the level of phosphorylation on Ser-262.	Serine	114-117	microtubule affinity regulating kinase 2	Homo sapiens	39-44
16257959-8	2005	These results, respectively, indicated that GSK-3beta is responsible for phosphorylating Ser-262 of tau through phosphorylation and activation of MARK2 and that the phosphorylation of tau at this particular site is predominantly mediated by a GSK-3beta-MARK2 pathway.	Serine	89-92	microtubule affinity regulating kinase 2	Homo sapiens	146-151
16257959-8	2005	These results, respectively, indicated that GSK-3beta is responsible for phosphorylating Ser-262 of tau through phosphorylation and activation of MARK2 and that the phosphorylation of tau at this particular site is predominantly mediated by a GSK-3beta-MARK2 pathway.	Serine	89-92	microtubule affinity regulating kinase 2	Homo sapiens	253-258
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Serine	273-279	microtubule affinity regulating kinase 2	Homo sapiens	26-32
19011111-4	2008	Here, we demonstrate that Par-1b is also regulated by another arm of the PKC pathway, one that involves novel PKCs (nPKC) and protein kinase D. Treatment of cells with the PKC activator phorbol-12-myristate-13-acetate (PMA) potently stimulated phosphorylation of Par-1b on serine 400 (S400), a residue that is conserved in all 4 mammalian Par-1 kinases as well as the fly ortholog.	Serine	273-279	microtubule affinity regulating kinase 2	Homo sapiens	26-31
18626018-9	2008	Taken together, these data provide the mechanistic underpinning for how cAMP and glucose cooperatively promote a transcriptional program critical for islet cell survival, and identifies MARK2 as a potential target for diabetes treatment.	Cyclic AMP	72-76	microtubule affinity regulating kinase 2	Homo sapiens	186-191
18626018-9	2008	Taken together, these data provide the mechanistic underpinning for how cAMP and glucose cooperatively promote a transcriptional program critical for islet cell survival, and identifies MARK2 as a potential target for diabetes treatment.	Glucose	81-88	microtubule affinity regulating kinase 2	Homo sapiens	186-191
16257959-4	2005	Our first finding that treatment of cells with LiCl, a selective inhibitor of another major tau kinase, glycogen synthase kinase-3beta (GSK-3beta), inhibits phosphorylation of Ser-262 of tau led us to investigate the possible involvement of GSK-3beta in MARK2 activation.	Lithium Chloride	47-51	microtubule affinity regulating kinase 2	Homo sapiens	254-259
16257959-4	2005	Our first finding that treatment of cells with LiCl, a selective inhibitor of another major tau kinase, glycogen synthase kinase-3beta (GSK-3beta), inhibits phosphorylation of Ser-262 of tau led us to investigate the possible involvement of GSK-3beta in MARK2 activation.	Serine	176-179	microtubule affinity regulating kinase 2	Homo sapiens	254-259
16257959-6	2005	Our further findings led us to conclude that GSK-3beta phosphorylates MARK2 on Ser-212, one of the two reported phosphorylation sites (Thr-208 and Ser-212) found in the activation loop of MARK2.	Serine	79-82	microtubule affinity regulating kinase 2	Homo sapiens	70-75
15084291-7	2004	hPar-1b is phosphorylated by aPKC on threonine 595, a residue conserved in Par-1 orthologs in mammals, worms, and flies.	Threonine	37-46	microtubule affinity regulating kinase 2	Homo sapiens	0-7
15084291-7	2004	hPar-1b is phosphorylated by aPKC on threonine 595, a residue conserved in Par-1 orthologs in mammals, worms, and flies.	Threonine	37-46	microtubule affinity regulating kinase 2	Homo sapiens	1-6
571219-8	1979	A similar mechanism has been proposed to explain increased halothane concentrations delivered by Fluotec Mark 2 vaporizers in the presence of nitrous oxide.	Halothane	59-68	microtubule affinity regulating kinase 2	Homo sapiens	105-111
10932692-2	1999	The Bird Ventilator Mark 2 is utilised as an oxygen pressure jet to drive an injector placed at the distal end of the double T-piece breathing system.	Oxygen	45-51	microtubule affinity regulating kinase 2	Homo sapiens	20-26
35532004-3	2022	Using mass spectrometry, we identified beta5 interactors including the Rho GEFs p115Rho-GEF and GEF-H1, and the serine protein kinase MARK2; depletion of which diminishes the clustering of beta5 in FCLs.	Serine	112-118	microtubule affinity regulating kinase 2	Homo sapiens	134-139
35532004-4	2022	Substitution of two serines (S759/762) in the beta5 cytoplasmic domain with phospho-mimetic glutamates causes a shift in the localization of beta5 from FAs into FCLs without affecting the interactions with MARK2, p115Rho-GEF or GEF-H1.	Serine	20-27	microtubule affinity regulating kinase 2	Homo sapiens	206-211
35532004-4	2022	Substitution of two serines (S759/762) in the beta5 cytoplasmic domain with phospho-mimetic glutamates causes a shift in the localization of beta5 from FAs into FCLs without affecting the interactions with MARK2, p115Rho-GEF or GEF-H1.	Glutamates	92-102	microtubule affinity regulating kinase 2	Homo sapiens	206-211
35048405-6	2022	TCGA data revealed that MARK2 expression was positively correlated with mTOR, Raptor, S6K1, glucose transporter 1, lactate dehydrogenase, HIF-1alpha, and 4E-BP1 expression, whereas negatively correlated with p53, p21, and Bax in breast cancer tissue.	Glucose	92-99	microtubule affinity regulating kinase 2	Homo sapiens	24-29
34953473-0	2022	Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients.	Lithium	65-72	microtubule affinity regulating kinase 2	Homo sapiens	11-16
34953473-3	2022	Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar patients using ARMS-PCR.	Lithium	62-69	microtubule affinity regulating kinase 2	Homo sapiens	36-41
34953473-3	2022	Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar patients using ARMS-PCR.	Lithium	62-69	microtubule affinity regulating kinase 2	Homo sapiens	88-93
6767537-2	1980	Vapour concentrations from a halothane Cyprane (Fluotec) Mark 2 increased in relation to the density of carrier gas, whereas the concentrations delivered by an enflurane Ohio vaporizer decreased.	fluotec	48-55	microtubule affinity regulating kinase 2	Homo sapiens	57-63
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Nitrous Oxide	24-37	microtubule affinity regulating kinase 2	Homo sapiens	142-148
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Oxygen	38-44	microtubule affinity regulating kinase 2	Homo sapiens	142-148
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Oxygen	68-74	microtubule affinity regulating kinase 2	Homo sapiens	142-148
6767537-4	1980	Of clinical importance, nitrous oxide/oxygen (75/25), compared with oxygen alone, increased the vapour concentration outputs of the halothane Mark 2 up to 30% and decreased the outputs of the enflurane Ohio unit up to 20%.	Halothane	132-141	microtubule affinity regulating kinase 2	Homo sapiens	142-148
571219-8	1979	A similar mechanism has been proposed to explain increased halothane concentrations delivered by Fluotec Mark 2 vaporizers in the presence of nitrous oxide.	Nitrous Oxide	142-155	microtubule affinity regulating kinase 2	Homo sapiens	105-111
32368441-0	2020	The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair.	Cisplatin	35-44	microtubule affinity regulating kinase 2	Homo sapiens	18-23
5059110-0	1972	Fluotec Mark 2 halothane output: nonlinearity from "off" to 0.5 per cent dial settings.	Halothane	15-24	microtubule affinity regulating kinase 2	Homo sapiens	8-14
1276004-3	1976	The output of the Fluotec Mark 2 at the 0.5 and 1% settings was highest with nitrous oxide as the carrier gas, but at 2, 3 and 4% settings it was highest with oxygen; at the 0.5% and 1% dial settings it was a function of carrier gas density, but at 2%, 3% and 4% it was a function of carrier gas viscosity.	Nitrous Oxide	77-90	microtubule affinity regulating kinase 2	Homo sapiens	26-32
1276004-3	1976	The output of the Fluotec Mark 2 at the 0.5 and 1% settings was highest with nitrous oxide as the carrier gas, but at 2, 3 and 4% settings it was highest with oxygen; at the 0.5% and 1% dial settings it was a function of carrier gas density, but at 2%, 3% and 4% it was a function of carrier gas viscosity.	Oxygen	159-165	microtubule affinity regulating kinase 2	Homo sapiens	26-32
5568139-0	1971	The effect of nitrous oxide on halothane output from Fluotec Mark 2 vaporizers.	Halothane	31-40	microtubule affinity regulating kinase 2	Homo sapiens	61-67
33989515-5	2021	The CagA/PAR1b interaction also stimulates Hippo signaling that circumvents apoptosis of DNA-damaged cells, giving cells time to repair DSBs through error-prone mechanisms.	dsbs	136-140	microtubule affinity regulating kinase 2	Homo sapiens	9-14
32509178-0	2020	MARK2 enhances cisplatin resistance via PI3K/AKT/NF-kappaB signaling pathway in osteosarcoma cells.	Cisplatin	15-24	microtubule affinity regulating kinase 2	Homo sapiens	0-5
32509178-4	2020	In this study, we investigate the role and potential mechanisms of microtubule-affinity regulating kinase2 (MARK2) during osteosarcoma cisplatin resistance.	Cisplatin	135-144	microtubule affinity regulating kinase 2	Homo sapiens	67-106
32509178-4	2020	In this study, we investigate the role and potential mechanisms of microtubule-affinity regulating kinase2 (MARK2) during osteosarcoma cisplatin resistance.	Cisplatin	135-144	microtubule affinity regulating kinase 2	Homo sapiens	108-113
32509178-7	2020	The overexpression and inhibition of MARK2 promoted and suppressed, respectively, cisplatin resistance in osteosarcoma cells in vitro and in vivo.	Cisplatin	82-91	microtubule affinity regulating kinase 2	Homo sapiens	37-42
32509178-8	2020	Mechanistically, MARK2 overexpression enhanced P-glycoprotein expression and decreased cell apoptosis through PI3K/AKT/NF-kappaB signaling pathway activation, resulting in cisplatin resistance.	Cisplatin	172-181	microtubule affinity regulating kinase 2	Homo sapiens	17-22
32509178-9	2020	Our results suggest that high MARK2 expression can enhance cisplatin resistance in osteosarcoma cells, supporting the potential of MARK2 as a new therapeutic target and biomarker for predicting cisplatin resistance in osteosarcoma.	Cisplatin	59-68	microtubule affinity regulating kinase 2	Homo sapiens	30-35
32368441-8	2020	Down regulation of MARK2 reduced the cisplatin resistance of CD133+ MG-63 cells, with deceasing expression of DNA-PKcs (p<0.05).	Cisplatin	37-46	microtubule affinity regulating kinase 2	Homo sapiens	19-24
32368441-11	2020	The reduction of MARK2 retarded the activity of PI3K/Akt/mTOR pathway and further impeded the cisplatin resistance in CD133+ MG-63 and MNNG/HOS cell.	Cisplatin	94-103	microtubule affinity regulating kinase 2	Homo sapiens	17-22
32368441-12	2020	Conclusion: Our data suggested that MARK2 was related to cisplatin resistance in CD133+ MG-63 and MNNG/HOS cells.	Cisplatin	57-66	microtubule affinity regulating kinase 2	Homo sapiens	36-41
32368441-13	2020	The decrease of MARK2 restricted the cisplatin resistance of CD133+ MG-63 and MNNG/HOS cells by down regulating the expression of DNA dependent protein kinase catalytic subunit (DNA-PKcs) and inhibiting activity of PI3K/Akt/mTOR signaling pathway, which provides new clues for the osteosarcoma chemotherapy strategy.	Cisplatin	37-46	microtubule affinity regulating kinase 2	Homo sapiens	16-21
31794565-5	2019	Mutational analysis of MARK2 revealed that the N-terminal kinase domain of MARK2 is sufficient for phosphorylation of both consensus and variant zetaXKXGSXXNPsi sites.	Nitrogen	47-48	microtubule affinity regulating kinase 2	Homo sapiens	23-28
31794565-5	2019	Mutational analysis of MARK2 revealed that the N-terminal kinase domain of MARK2 is sufficient for phosphorylation of both consensus and variant zetaXKXGSXXNPsi sites.	Nitrogen	47-48	microtubule affinity regulating kinase 2	Homo sapiens	75-80
31080060-0	2019	High-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1b.	Hyaluronic Acid	22-32	microtubule affinity regulating kinase 2	Homo sapiens	114-119
31461655-6	2019	In contrast, in the somatodendritic area under high MARK2 activity, KAP3 phosphorylated at serine 60 by MARK2 cannot bind with TRIM46 and be transported.	Serine	91-97	microtubule affinity regulating kinase 2	Homo sapiens	52-57
31461655-6	2019	In contrast, in the somatodendritic area under high MARK2 activity, KAP3 phosphorylated at serine 60 by MARK2 cannot bind with TRIM46 and be transported.	Serine	91-97	microtubule affinity regulating kinase 2	Homo sapiens	104-109
31080060-3	2019	Mechanistically, clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex.	Hyaluronic Acid	86-96	microtubule affinity regulating kinase 2	Homo sapiens	152-157
31080060-3	2019	Mechanistically, clustering of the CD44 extracellular domain by high-molecular-weight hyaluronan leads to recruitment of the polarity-regulating kinase PAR1b by the CD44 intracellular domain, which results in disruption of the Hippo signaling-inhibitory PAR1b-MST complex.	Hyaluronic Acid	86-96	microtubule affinity regulating kinase 2	Homo sapiens	254-259
27878245-0	2017	Baicalin attenuates DDP (cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt.	Cisplatin	25-34	microtubule affinity regulating kinase 2	Homo sapiens	80-85
30374120-2	2018	Upon delivery into gastric epithelial cells via type IV secretion, the cagA-encoded CagA interacts with and thereby perturbs the pro-oncogenic phosphatase SHP2 and the polarity-regulating kinase PAR1b via the tyrosine-phosphorylated EPIYA-C/D segment and the CM sequence, respectively.	Tyrosine	209-217	microtubule affinity regulating kinase 2	Homo sapiens	195-200
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	27-33	microtubule affinity regulating kinase 2	Homo sapiens	167-172
27714636-8	2017	Finally, the detections of folate concentration in human brain tissue and NSCs and MEF cells indicates that folate deficiency contributes to the observed decreases in Mark2 and Dvl1 expression.	Folic Acid	108-114	microtubule affinity regulating kinase 2	Homo sapiens	167-172
25907283-6	2015	Finally, we show that high MARK2 expression levels correlate with resistance to cisplatin, a standard first line chemotherapy for lung cancer.	Cisplatin	80-89	microtubule affinity regulating kinase 2	Homo sapiens	27-32
25907283-7	2015	Collectively, our work supports a role for MARK2 in promoting malignant phenotypes of lung cancer and potentially modulating response to the DNA damaging chemotherapeutic, cisplatin.	Cisplatin	172-181	microtubule affinity regulating kinase 2	Homo sapiens	43-48
23720287-8	2013	The serine/threonine kinase LKB1, which is activated by the bile acid taurocholate and, in turn, activates adenosine monophosphate kinase-related kinases including AMPK1/2 and Par1 paralogues has emerged as a key determinant of hepatic polarity.	Bile Acids and Salts	60-69	microtubule affinity regulating kinase 2	Homo sapiens	176-180
26383144-3	2015	We have used this technology to identify MAP/microtubule affinity-regulating kinase 2 (MARK2) as the kinase for a glucose-regulated site on CREB-Regulated Transcriptional Coactivator 2 (CRTC2), a protein required for beta cell proliferation, as well as the Axl family of tyrosine kinases as regulators of cell metastasis by phosphorylation of the adaptor protein ELMO.	Glucose	114-121	microtubule affinity regulating kinase 2	Homo sapiens	41-85
26383144-3	2015	We have used this technology to identify MAP/microtubule affinity-regulating kinase 2 (MARK2) as the kinase for a glucose-regulated site on CREB-Regulated Transcriptional Coactivator 2 (CRTC2), a protein required for beta cell proliferation, as well as the Axl family of tyrosine kinases as regulators of cell metastasis by phosphorylation of the adaptor protein ELMO.	Glucose	114-121	microtubule affinity regulating kinase 2	Homo sapiens	87-92
25512381-0	2015	Protein kinase A rescues microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating serine 409.	Serine	140-146	microtubule affinity regulating kinase 2	Homo sapiens	25-65
25512381-4	2015	PKA was found to inhibit MARK2 kinase activity by phosphorylating a novel site, serine 409.	Serine	80-86	microtubule affinity regulating kinase 2	Homo sapiens	25-30
25512381-6	2015	In contrast, mutation of MARK2 serine 409 to glutamic acid (Glu) (MARK2 S409E) did not affect microtubule stability and neurite outgrowth.	Glutamic Acid	60-63	microtubule affinity regulating kinase 2	Homo sapiens	25-30
25512381-6	2015	In contrast, mutation of MARK2 serine 409 to glutamic acid (Glu) (MARK2 S409E) did not affect microtubule stability and neurite outgrowth.	Glutamic Acid	60-63	microtubule affinity regulating kinase 2	Homo sapiens	66-71
24259665-7	2014	Par-1b binds to and phosphorylates RNF41 on serine 254.	Serine	44-50	microtubule affinity regulating kinase 2	Homo sapiens	0-6
24251416-5	2013	We demonstrate that MARK2 binds to the N-terminal tail of Tau and selectively phosphorylates three major and five minor serine residues in the repeat domain and C-terminal tail.	Serine	120-126	microtubule affinity regulating kinase 2	Homo sapiens	20-25
23720287-8	2013	The serine/threonine kinase LKB1, which is activated by the bile acid taurocholate and, in turn, activates adenosine monophosphate kinase-related kinases including AMPK1/2 and Par1 paralogues has emerged as a key determinant of hepatic polarity.	Taurocholic Acid	70-82	microtubule affinity regulating kinase 2	Homo sapiens	176-180
23001711-6	2013	Staurosporine, a protein kinase inhibitor, significantly reduced the interaction between MARK2 and tau, and also phosphorylation of tau at Ser(262).	Staurosporine	0-13	microtubule affinity regulating kinase 2	Homo sapiens	89-94
23001711-8	2013	Our results from transfected cells demonstrate a specific interaction between MARK2 and tau, as well as MARK2-dependent phosphorylation of tau at Ser(262).	Serine	146-149	microtubule affinity regulating kinase 2	Homo sapiens	104-109
22072711-5	2011	Here we show that PAR1b induces phosphorylation of GEF-H1 on serine 885 and serine 959.	Serine	61-67	microtubule affinity regulating kinase 2	Homo sapiens	18-23
22238344-0	2012	Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.	Threonine	124-127	microtubule affinity regulating kinase 2	Homo sapiens	0-40
22238344-0	2012	Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport.	Threonine	124-127	microtubule affinity regulating kinase 2	Homo sapiens	42-47
22139392-1	2012	The serine/threonine kinase, PAR-1, is an essential component of the evolutionary-conserved polarity-regulating system, PAR-aPKC system, which plays indispensable roles in establishing asymmetric protein distributions and cell polarity in various biological contexts (Suzuki, A. and Ohno, S. (2006).	ohno	283-287	microtubule affinity regulating kinase 2	Homo sapiens	29-34
22072711-5	2011	Here we show that PAR1b induces phosphorylation of GEF-H1 on serine 885 and serine 959.	Serine	76-82	microtubule affinity regulating kinase 2	Homo sapiens	18-23
22072711-6	2011	We also show that PAR1b-induced serine 885/serine 959 phosphorylation inhibits RhoA-specific GEF activity of GEF-H1.	Serine	32-38	microtubule affinity regulating kinase 2	Homo sapiens	18-23
22072711-6	2011	We also show that PAR1b-induced serine 885/serine 959 phosphorylation inhibits RhoA-specific GEF activity of GEF-H1.	Serine	43-49	microtubule affinity regulating kinase 2	Homo sapiens	18-23
21513698-5	2011	We find that Par1b phosphorylates GEF-H1 at three serine residues conserved in vertebrates and releases GEF-H1 from microtubules, which abrogates stabilization and acetylation of microtubules induced by GEF-H1 overexpression.	Serine	50-56	microtubule affinity regulating kinase 2	Homo sapiens	13-18
21145462-2	2010	Here, we identify the KA1 domain (kinase associated-1 domain), found at the C terminus of yeast septin-associated kinases (Kcc4p, Gin4p, and Hsl1p) and human MARK/PAR1 kinases, as a membrane association domain that binds acidic phospholipids.	Phospholipids	228-241	microtubule affinity regulating kinase 2	Homo sapiens	163-167
21513698-6	2011	The alanine mutant for the three phosphorylation sites (3SA) of GEF-H1 strongly induces stabilization and acetylation of microtubules, which was resistant to Par1b.	Alanine	4-11	microtubule affinity regulating kinase 2	Homo sapiens	158-163