PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 26913920-1 2016 PURPOSE: Four mitochondrial metabolic liver enzymes require bicarbonate, which is provided by the carbonic anhydrase isoforms VA (CAVA) and VB (CAVB). Bicarbonates 60-71 carbonic anhydrase 5A Homo sapiens 130-134 29701427-0 2017 Heparin Resistance During Surgical Resection of Inferior Vena Cava and Right Atrial Tumor Thrombus: A Case Report. Heparin 0-7 carbonic anhydrase 5A Homo sapiens 62-66 29701427-2 2017 We present the case of a 47-year-old female patient, ASA 2, who was diagnosed with a neuroendocrine retroperitoneal tumor with thrombus in the left renal vein, inferior vena cava and right atrium. altersolanol A 53-58 carbonic anhydrase 5A Homo sapiens 174-178 28131914-0 2017 Regulation of high glucose-induced apoptosis of brain pericytes by mitochondrial CA VA: A specific target for prevention of diabetic cerebrovascular pathology. Glucose 19-26 carbonic anhydrase 5A Homo sapiens 81-86 28131914-8 2017 In a recent genetic study, we showed that mitochondrial CA VA plays a significant role in regulation of reactive oxygen species and pericyte death. Reactive Oxygen Species 104-127 carbonic anhydrase 5A Homo sapiens 56-61 27365118-6 2016 In silico studies were also performed to analyse the effect of GdnHCl on the structure and stability of CAVA under explicit conditions. Guanidine 63-69 carbonic anhydrase 5A Homo sapiens 104-108 28330086-1 2016 Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 98-101 carbonic anhydrase 5A Homo sapiens 0-21 26421381-0 2016 Spectroscopic and MD simulation studies on unfolding processes of mitochondrial carbonic anhydrase VA induced by urea. Urea 113-117 carbonic anhydrase 5A Homo sapiens 80-101 26421381-2 2016 To understand the biophysical properties of CAVA, we carried out a reversible urea-induced isothermal denaturation at pH 7.0 and 25 C. Spectroscopic probes, [theta]222 (mean residue ellipticity at 222 nm), F344 (Trp-fluorescence emission intensity at 344 nm) and Deltaepsilon280 (difference absorption at 280 nm) were used to monitor the effect of urea on the structure and stability of CAVA. Urea 78-82 carbonic anhydrase 5A Homo sapiens 44-48 26421381-5 2016 We further performed 40 ns molecular dynamics simulation of CAVA to see the dynamics at different urea concentrations. Urea 98-102 carbonic anhydrase 5A Homo sapiens 60-64 27365118-0 2016 GdnHCl-induced unfolding intermediate in the mitochondrial carbonic anhydrase VA. Guanidine 0-6 carbonic anhydrase 5A Homo sapiens 59-80 27365118-2 2016 Here, we have tried to understand the folding mechanism of CAVA using guanidine hydrochloride (GdnHCl)-induced denaturation at pH 8.0 and 25 C. The conformational stability was measured from the GdnHCl-induced denaturation study of CAVA monitored by circular dichroism (CD) and fluorescence measurements. Guanidine 70-93 carbonic anhydrase 5A Homo sapiens 59-63 27365118-2 2016 Here, we have tried to understand the folding mechanism of CAVA using guanidine hydrochloride (GdnHCl)-induced denaturation at pH 8.0 and 25 C. The conformational stability was measured from the GdnHCl-induced denaturation study of CAVA monitored by circular dichroism (CD) and fluorescence measurements. Guanidine 70-93 carbonic anhydrase 5A Homo sapiens 232-236 27365118-2 2016 Here, we have tried to understand the folding mechanism of CAVA using guanidine hydrochloride (GdnHCl)-induced denaturation at pH 8.0 and 25 C. The conformational stability was measured from the GdnHCl-induced denaturation study of CAVA monitored by circular dichroism (CD) and fluorescence measurements. Guanidine 95-101 carbonic anhydrase 5A Homo sapiens 59-63 27365118-2 2016 Here, we have tried to understand the folding mechanism of CAVA using guanidine hydrochloride (GdnHCl)-induced denaturation at pH 8.0 and 25 C. The conformational stability was measured from the GdnHCl-induced denaturation study of CAVA monitored by circular dichroism (CD) and fluorescence measurements. Guanidine 95-101 carbonic anhydrase 5A Homo sapiens 232-236 27365118-2 2016 Here, we have tried to understand the folding mechanism of CAVA using guanidine hydrochloride (GdnHCl)-induced denaturation at pH 8.0 and 25 C. The conformational stability was measured from the GdnHCl-induced denaturation study of CAVA monitored by circular dichroism (CD) and fluorescence measurements. Guanidine 195-201 carbonic anhydrase 5A Homo sapiens 59-63 27365118-4 2016 However, CAVA gets completely denatured at 4.0M GdnHCl. Guanidine 48-54 carbonic anhydrase 5A Homo sapiens 9-13 28330086-1 2016 Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 98-101 carbonic anhydrase 5A Homo sapiens 23-27 28330086-1 2016 Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton. Bicarbonates 113-117 carbonic anhydrase 5A Homo sapiens 0-21 28330086-1 2016 Carbonic anhydrase VA (CAVA) is a mitochondrial enzyme that catalyzes the reversible hydration of CO2 to produce HCO3- and proton. Bicarbonates 113-117 carbonic anhydrase 5A Homo sapiens 23-27 28330086-2 2016 CAV is primarily involved in several biosynthetic processes such as ureagenesis, gluconeogenesis and lipogenesis by providing bicarbonate ion. Bicarbonates 126-137 carbonic anhydrase 5A Homo sapiens 0-3 28330086-6 2016 CAVA was purified under denatured conditions in a single step using Ni-NTA chromatography. ni-nta 68-74 carbonic anhydrase 5A Homo sapiens 0-4 28330086-7 2016 SDS-PAGE showed a band of 30-kDa, which was further confirmed as CAVA by Western blot and MALDI-TOF/MS. Sodium Dodecyl Sulfate 0-3 carbonic anhydrase 5A Homo sapiens 65-69 24012377-2 2013 4ITP is a medium potency hCA I and II inhibitor (KIs of 54-75nM), a strong mitochondrial CA VA/VB inhibitor (KIs of 8.3-8.6nM) and a weak transmembrane CA inhibitor (KIs of 136-212nM against hCA IX and XII). 2-phenyl-N-(4-sulfamoylbenzyl)acetamide 0-4 carbonic anhydrase 5A Homo sapiens 89-94 26805098-0 2015 [Survival after Sorafenib Treatment for Advanced Recurrent Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava]. Sorafenib 16-25 carbonic anhydrase 5A Homo sapiens 125-129 26004220-4 2015 For instance, Mg(2+) and Zn(2+) favor the substitution at the Ca-5 site of beta-TCP while Sr(2+) and Ba(2+) tend to occupy Ca-3 and Ca-4 in the beta-type crystal structure. Magnesium 14-16 carbonic anhydrase 5A Homo sapiens 62-66 26004220-4 2015 For instance, Mg(2+) and Zn(2+) favor the substitution at the Ca-5 site of beta-TCP while Sr(2+) and Ba(2+) tend to occupy Ca-3 and Ca-4 in the beta-type crystal structure. Zinc 25-27 carbonic anhydrase 5A Homo sapiens 62-66 26004220-4 2015 For instance, Mg(2+) and Zn(2+) favor the substitution at the Ca-5 site of beta-TCP while Sr(2+) and Ba(2+) tend to occupy Ca-3 and Ca-4 in the beta-type crystal structure. beta-tricalcium phosphate 75-83 carbonic anhydrase 5A Homo sapiens 62-66 22299576-5 2013 These coumarins thus act as isoform-selective CA inhibitors with the possibility to target isoforms involved in pathologies such as obesity (CA VA/VB) or cancer (CA IX and XII) without inhibiting the physiologically dominant, highly abundant hCA I and II. Coumarins 6-15 carbonic anhydrase 5A Homo sapiens 141-146 22825404-1 2013 This study explores the possible effects of the North Atlantic Oscillation (NAO) on the quality of Spanish Cava. 10-N-nonylacridinium orange 76-79 carbonic anhydrase 5A Homo sapiens 107-111 22825404-2 2013 We found a significant negative relationship between the mean NAO for the months of March through August of each year between 1970 and 2008 and the probability of obtaining a top quality Cava. 10-N-nonylacridinium orange 62-65 carbonic anhydrase 5A Homo sapiens 187-191 22825404-3 2013 The NAO is associated with temperature and rainfall variations in the Cava region, which affect vine physiological processes during grape maturity. 10-N-nonylacridinium orange 4-7 carbonic anhydrase 5A Homo sapiens 70-74 22825404-4 2013 The probability of obtaining a top quality Cava was highest when the mean value of the NAO was negative, which causes the mean temperature in the Cava area to decrease, with positive consequences on Cava quality. 10-N-nonylacridinium orange 87-90 carbonic anhydrase 5A Homo sapiens 43-47 22825404-4 2013 The probability of obtaining a top quality Cava was highest when the mean value of the NAO was negative, which causes the mean temperature in the Cava area to decrease, with positive consequences on Cava quality. 10-N-nonylacridinium orange 87-90 carbonic anhydrase 5A Homo sapiens 146-150 22825404-4 2013 The probability of obtaining a top quality Cava was highest when the mean value of the NAO was negative, which causes the mean temperature in the Cava area to decrease, with positive consequences on Cava quality. 10-N-nonylacridinium orange 87-90 carbonic anhydrase 5A Homo sapiens 146-150 19539481-6 2009 As hCA VA/VB are involved in several biosynthetic processes catalyzed by pyruvate carboxylase, acetyl CoA carboxylase, and carbamoyl phosphate synthetases I and II, providing the bicarbonate substrate to these carboxylating enzymes involved in fatty acid biosynthesis, their selective inhibition may lead to the development of antiobesity agents possessing a new mechanism of action. Bicarbonates 179-190 carbonic anhydrase 5A Homo sapiens 3-9 23382808-5 2013 Asn153 and Asp176 are directly coordinated with Ca3 and indirectly coordinated with Ca5 via a water molecule. Water 94-99 carbonic anhydrase 5A Homo sapiens 84-87 23382808-7 2013 Asp168 is the direct ligand for Ca5, and Ca5 coordination by Glu252 is mediated by two water molecules. Water 87-92 carbonic anhydrase 5A Homo sapiens 41-44 22624680-6 2012 KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6). na-5ht 13-19 carbonic anhydrase 5A Homo sapiens 41-46 22624680-6 2012 KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6). na-5ht 13-19 carbonic anhydrase 5A Homo sapiens 101-106 22624680-7 2012 The effects of NA-5HT were voltage-dependent, and it produced significant hyperpolarizing shifts in Ca(V) 3 steady-state inactivation relationships. na-5ht 15-21 carbonic anhydrase 5A Homo sapiens 100-105 22624680-8 2012 NA-5HT selectively affected Ca(V) 3.3 channel kinetics. na-5ht 0-6 carbonic anhydrase 5A Homo sapiens 28-33 22442573-5 2012 Using single-particle tracking techniques, we measured the expansion of Ca(V) channel confinement domains caused by depletion of membrane cholesterol with cholesterol oxidase or methyl-beta-cyclodextrin. Cholesterol 138-149 carbonic anhydrase 5A Homo sapiens 72-77 22442573-5 2012 Using single-particle tracking techniques, we measured the expansion of Ca(V) channel confinement domains caused by depletion of membrane cholesterol with cholesterol oxidase or methyl-beta-cyclodextrin. methyl-beta-cyclodextrin 178-202 carbonic anhydrase 5A Homo sapiens 72-77 22442573-10 2012 Replenishing cholesterol restored Ca(V) channel domain size and release efficiency to control levels. Cholesterol 13-24 carbonic anhydrase 5A Homo sapiens 34-39 22442573-12 2012 Furthermore, the finding that cholesterol depletion impairs coupling between channel opening and vesicle release by allowing Ca(V) channels to move further from release sites shows that changes in presynaptic Ca(V) channel mobility can be a mechanism for adjusting synaptic strength. Cholesterol 30-41 carbonic anhydrase 5A Homo sapiens 125-130 22442573-12 2012 Furthermore, the finding that cholesterol depletion impairs coupling between channel opening and vesicle release by allowing Ca(V) channels to move further from release sites shows that changes in presynaptic Ca(V) channel mobility can be a mechanism for adjusting synaptic strength. Cholesterol 30-41 carbonic anhydrase 5A Homo sapiens 209-214 22308488-8 2012 In addition, the Lyn-beta3 subunit significantly decreased Ca(V) channel inhibition by PIP(2) depletion. Phosphatidylinositol 4,5-Diphosphate 87-93 carbonic anhydrase 5A Homo sapiens 59-64 22308488-10 2012 Compared with expression with Ca(V) beta3-subunits alone, inhibition of Ca(V)2.2 channels by PIP(2) depletion could be significantly attenuated when beta2a was coexpressed with beta3. Phosphatidylinositol 4,5-Diphosphate 93-99 carbonic anhydrase 5A Homo sapiens 30-35 22308488-11 2012 Our data suggest that the Ca(V) currents in neurons would be regulated by membrane PIP(2) to a degree that depends on their endogenous beta-subunit combinations. Phosphatidylinositol 4,5-Diphosphate 83-89 carbonic anhydrase 5A Homo sapiens 26-31 21300547-2 2011 The new sulfonamides selectively inhibited the mitochondrial isozymes hCA VA and VB (h=human isoform) over the cytosolic, off-target ones hCA I and II, with inhibition constants in the low nanomolar range. Sulfonamides 8-20 carbonic anhydrase 5A Homo sapiens 70-83 19962903-4 2010 The selectivity ratios for inhibiting the mitochondrial over the cytosolic isoforms for these phenol derivatives were in the range of 120-3800, making them the most isoform-selective compounds for inhibiting hCA VA/VB known to date. Phenol 94-100 carbonic anhydrase 5A Homo sapiens 208-214 22624680-9 2012 CONCLUSIONS AND IMPLICATIONS: NA-5HT increases the steady-state inactivation of Ca(V) 3 channels, reducing the number of channels available to open during depolarization. na-5ht 30-36 carbonic anhydrase 5A Homo sapiens 80-85 19539481-6 2009 As hCA VA/VB are involved in several biosynthetic processes catalyzed by pyruvate carboxylase, acetyl CoA carboxylase, and carbamoyl phosphate synthetases I and II, providing the bicarbonate substrate to these carboxylating enzymes involved in fatty acid biosynthesis, their selective inhibition may lead to the development of antiobesity agents possessing a new mechanism of action. Fatty Acids 244-254 carbonic anhydrase 5A Homo sapiens 3-9 18990571-1 2008 A series of 2-substituted-1,3,4-thiadiazole-5-sulfamides was prepared and assayed as inhibitors of several carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic CA I and II, the membrane-associated CA IV and the mitochondrial CA VA and VB. 2-substituted-1,3,4-thiadiazole-5-sulfamides 12-56 carbonic anhydrase 5A Homo sapiens 232-237 19095299-5 2009 FT-IR analysis displayed carbonate levels in CA5 and CA10 dropped to approximately 1.1-2.2% after sintering, whereas SEM imaging displayed CA5 and CA10 possess distinct morphologies. Carbonates 25-34 carbonic anhydrase 5A Homo sapiens 45-48 19237593-1 2009 Two processes dominate voltage-gated calcium channel (Ca(V)) inactivation: voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). Calcium 37-44 carbonic anhydrase 5A Homo sapiens 53-59 19237593-5 2009 Remarkably, mutations that either break the rigid IS6-AID linker connection or disrupt Ca(V)beta/I-II association sharply decelerate CDI and reduce a second Ca(2+)/CaM/Ca(V)alpha(1)-C-terminal-mediated process known as calcium-dependent facilitation. Calcium 219-226 carbonic anhydrase 5A Homo sapiens 168-178 18990571-3 2008 Furthermore, the selectivity ratios for inhibiting the mitochondrial enzymes over CA II were in the range of 67.5-415, making these sulfamides the first selective CA VA/VB inhibitors. sulfamides 132-142 carbonic anhydrase 5A Homo sapiens 163-168 17420132-2 2007 To better understand the interaction of these compounds with CAs, here, we report a homology modeling and molecular dynamics simulations study on their adducts with human carbonic anhydrase VA (hCA VA). Calcium 61-64 carbonic anhydrase 5A Homo sapiens 194-200 18242985-2 2008 Phenol was an effective CA I-IV, IX, XII and XIV inhibitor (K(I)s of 2.7-11.5 microM) and a less effective one against the other isoforms, CA VA, VB, VI, VII, and XIII (K(I)s of 208-710 micraoM). Phenol 0-6 carbonic anhydrase 5A Homo sapiens 139-144 18184831-1 2008 Calcium influx through long-lasting ("L-type") Ca(2+) channels (Ca(V)) drives excitation-contraction in the normal heart. Calcium 0-7 carbonic anhydrase 5A Homo sapiens 64-69 17420132-5 2007 In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms. Hydrogen 93-101 carbonic anhydrase 5A Homo sapiens 130-136 17420132-5 2007 In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms. Zonisamide 200-210 carbonic anhydrase 5A Homo sapiens 130-136 17420132-5 2007 In particular, our data suggest that a narrower active site cleft, together with a different hydrogen bond network arrangement of hCA VA compared to hCA II, may account for the different Kd values of zonisamide and topiramate toward these physiologically relevant hCA isoforms. Topiramate 215-225 carbonic anhydrase 5A Homo sapiens 130-136 17125255-1 2006 The sulfamide analogue of the antiepileptic drug topiramate is a 210 times less potent inhibitor of isozyme II of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) compared to topiramate but effectively inhibits isozymes CA VA, VB, VII, XIII, and XIV (KI in the range of 21-35 nM). fusarubin 4-13 carbonic anhydrase 5A Homo sapiens 223-228 17125255-1 2006 The sulfamide analogue of the antiepileptic drug topiramate is a 210 times less potent inhibitor of isozyme II of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) compared to topiramate but effectively inhibits isozymes CA VA, VB, VII, XIII, and XIV (KI in the range of 21-35 nM). Topiramate 49-59 carbonic anhydrase 5A Homo sapiens 223-228 15501037-7 2004 The mitochondrial isozyme hCA V was weakly inhibited by all phosphates/phosphonates, except carbamoyl phosphate, which showed a K(I) of 8.5 microM. Phosphates 60-70 carbonic anhydrase 5A Homo sapiens 26-31 15664815-7 2005 Furthermore, the relative resistance of CA V to inhibition by pyruvate may be an evolutionary adaptation of this mitochondrial isozyme to the presence of high concentrations of this anion within this organelle. Pyruvic Acid 62-70 carbonic anhydrase 5A Homo sapiens 40-44 15633752-6 2004 In CI-MS, the main ion peaks of dm-CA5-, dm-CA6-, dm-CA7-, and dm-CA8P1EC after methylation were at m/z= 129, 143, 157, and 171, respectively, corresponding to the loss of methyl phenoxyacetate from [M+ H]+; meanwhile significant peaks were detected at 321, 335, 349, and 363, corresponding to the loss of the trimethylsilanol after trimethylsilylation. Phenoxyacetates 179-193 carbonic anhydrase 5A Homo sapiens 35-38 15633752-6 2004 In CI-MS, the main ion peaks of dm-CA5-, dm-CA6-, dm-CA7-, and dm-CA8P1EC after methylation were at m/z= 129, 143, 157, and 171, respectively, corresponding to the loss of methyl phenoxyacetate from [M+ H]+; meanwhile significant peaks were detected at 321, 335, 349, and 363, corresponding to the loss of the trimethylsilanol after trimethylsilylation. trimethylsilanol 310-326 carbonic anhydrase 5A Homo sapiens 35-38 15633752-7 2004 The potential for the identification and quantification of individual branched carboxyalkyl isomeric mixtures of CA5-, CA6-, CA7-, and CA8P1EC metabolites based on corresponding dm-CA5-8P1ECs revealed the advantage of the GC-CI-MS although the detection limits in CI were clearly higher than those in EI. carboxyalkyl 79-91 carbonic anhydrase 5A Homo sapiens 113-116 15633752-7 2004 The potential for the identification and quantification of individual branched carboxyalkyl isomeric mixtures of CA5-, CA6-, CA7-, and CA8P1EC metabolites based on corresponding dm-CA5-8P1ECs revealed the advantage of the GC-CI-MS although the detection limits in CI were clearly higher than those in EI. carboxyalkyl 79-91 carbonic anhydrase 5A Homo sapiens 181-184 16686544-3 2006 l-Phe was a potent activator of isozymes I, II, and XIV (K(A)s of 13-240 nM), a weaker activator of hCA VA and VII (K(A)s of 9.8-10.9 microM), and a quite inefficient hCA IV activator (K(A) of 52 microM). Phenylalanine 0-5 carbonic anhydrase 5A Homo sapiens 100-114 16686544-4 2006 d-Phe showed good hCA II activatory properties (K(A) of 35 nM), being a moderate hCA VA, VII, and XIV (K(A)s of 4.6-9.7 microM) and a weak hCA I and IV activator (K(A)s of 63-86 microM). Phenylalanine 2-5 carbonic anhydrase 5A Homo sapiens 81-87 16203142-4 2005 Remarkably, some derivatives, such as 3-bromophenyl-difluoromethanesulfonamide, showed a trend to selectively inhibit the mitochondrial isoform CA VA, showing selectivity ratios for inhibiting CA VA over CA II of 3.53; over CA I of 6.84 and over CA IX of 9.34, respectively, although it is a moderate inhibitor (K(I) of 160nM). 3-bromophenyl-difluoromethanesulfonamide 38-78 carbonic anhydrase 5A Homo sapiens 144-149 16203142-4 2005 Remarkably, some derivatives, such as 3-bromophenyl-difluoromethanesulfonamide, showed a trend to selectively inhibit the mitochondrial isoform CA VA, showing selectivity ratios for inhibiting CA VA over CA II of 3.53; over CA I of 6.84 and over CA IX of 9.34, respectively, although it is a moderate inhibitor (K(I) of 160nM). 3-bromophenyl-difluoromethanesulfonamide 38-78 carbonic anhydrase 5A Homo sapiens 193-198 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Alanine 0-7 carbonic anhydrase 5A Homo sapiens 23-26 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Alanine 0-7 carbonic anhydrase 5A Homo sapiens 103-106 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Alanine 0-7 carbonic anhydrase 5A Homo sapiens 103-106 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Threonine 43-46 carbonic anhydrase 5A Homo sapiens 23-26 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Threonine 43-46 carbonic anhydrase 5A Homo sapiens 103-106 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Threonine 43-46 carbonic anhydrase 5A Homo sapiens 103-106 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Phenylalanine 71-74 carbonic anhydrase 5A Homo sapiens 23-26 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Phenylalanine 71-74 carbonic anhydrase 5A Homo sapiens 103-106 15637154-5 2005 Alanine scanning of AP-Cav-B revealed that Thr-90 and -91 (T90,91) and Phe-92 (F92) are crucial for AP-Cav-B- and AP-Cav-mediated inhibition of eNOS. Phenylalanine 71-74 carbonic anhydrase 5A Homo sapiens 103-106 15501037-7 2004 The mitochondrial isozyme hCA V was weakly inhibited by all phosphates/phosphonates, except carbamoyl phosphate, which showed a K(I) of 8.5 microM. Organophosphonates 71-83 carbonic anhydrase 5A Homo sapiens 26-31 15501037-7 2004 The mitochondrial isozyme hCA V was weakly inhibited by all phosphates/phosphonates, except carbamoyl phosphate, which showed a K(I) of 8.5 microM. Carbamyl Phosphate 92-111 carbonic anhydrase 5A Homo sapiens 26-31 15501037-9 2004 Furthermore, the relative resistance of CA V to inhibition by inorganic phosphates suggests an evolutionary adaptation of this mitochondrial isozyme to the presence of high concentrations of such anions in these energy-converting organelles, where high amounts of ATP are produced by ATP synthetase, from ADP and inorganic phosphates. inorganic 62-71 carbonic anhydrase 5A Homo sapiens 40-44 15501037-9 2004 Furthermore, the relative resistance of CA V to inhibition by inorganic phosphates suggests an evolutionary adaptation of this mitochondrial isozyme to the presence of high concentrations of such anions in these energy-converting organelles, where high amounts of ATP are produced by ATP synthetase, from ADP and inorganic phosphates. Phosphates 72-82 carbonic anhydrase 5A Homo sapiens 40-44 15501037-9 2004 Furthermore, the relative resistance of CA V to inhibition by inorganic phosphates suggests an evolutionary adaptation of this mitochondrial isozyme to the presence of high concentrations of such anions in these energy-converting organelles, where high amounts of ATP are produced by ATP synthetase, from ADP and inorganic phosphates. Adenosine Triphosphate 264-267 carbonic anhydrase 5A Homo sapiens 40-44 15501037-9 2004 Furthermore, the relative resistance of CA V to inhibition by inorganic phosphates suggests an evolutionary adaptation of this mitochondrial isozyme to the presence of high concentrations of such anions in these energy-converting organelles, where high amounts of ATP are produced by ATP synthetase, from ADP and inorganic phosphates. Phosphates 323-333 carbonic anhydrase 5A Homo sapiens 40-44 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Bicarbonates 86-97 carbonic anhydrase 5A Homo sapiens 52-57 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Bicarbonates 86-97 carbonic anhydrase 5A Homo sapiens 285-290 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Carbonates 88-97 carbonic anhydrase 5A Homo sapiens 52-57 15501038-7 2004 It has been observed that among all these isozymes, hCA V has the lowest affinity for bicarbonate and carbonate (K(i)"s in the range of 82-95 mM), which may represent an evolutionary adaptation of this isozyme to the rather alkaline environment (pH 8.5) within the mitochondria, where hCA V plays important functions in some biosynthetic reactions involving carboxylating enzymes (pyruvate carboxylase and acetyl coenzyme A carboxylase). Carbonates 88-97 carbonic anhydrase 5A Homo sapiens 285-290 15482952-7 2004 Only one compound, 2-carboxymethyl-benzenesulfonamide, was more active against hCA V over hCA II (selectivity ratio of 1.39), whereas all other derivatives investigated here were much better hCA II inhibitors (selectivity ratios CA II/CA V in the range of 0.0008-0.73) than hCA V inhibitors. 2-carboxymethyl-benzenesulfonamide 19-53 carbonic anhydrase 5A Homo sapiens 79-84 15482952-7 2004 Only one compound, 2-carboxymethyl-benzenesulfonamide, was more active against hCA V over hCA II (selectivity ratio of 1.39), whereas all other derivatives investigated here were much better hCA II inhibitors (selectivity ratios CA II/CA V in the range of 0.0008-0.73) than hCA V inhibitors. 2-carboxymethyl-benzenesulfonamide 19-53 carbonic anhydrase 5A Homo sapiens 80-84 11928941-9 2002 The acquired enzymatic injury resulting from the inhibition of mitochondrial carbonic anhydrase V that provides bicarbonate to pyruvate carboxylase can produce tricarboxylic acid cycle damage. Bicarbonates 112-123 carbonic anhydrase 5A Homo sapiens 77-97 12142734-7 2002 Hence, it is possible that PC and CPS I in the centroacinar cells, intercalated duct cells, and intralobular duct cells are strongly activated and might use HCO3- ions provided by CA II and not by CA V. cps i 34-39 carbonic anhydrase 5A Homo sapiens 197-201 11928941-9 2002 The acquired enzymatic injury resulting from the inhibition of mitochondrial carbonic anhydrase V that provides bicarbonate to pyruvate carboxylase can produce tricarboxylic acid cycle damage. Tricarboxylic Acids 160-178 carbonic anhydrase 5A Homo sapiens 77-97 11310605-8 2001 The mechanism of antitumor action with the new sulfonamides reported here remains obscure, but may involve inhibition of CA isozymes which predominate in tumor cell membranes (CA IX and CA XII), perhaps causing acidification of the intercellular milieu, or inhibition of intracellular isozymes which provide bicarbonate for the synthesis of nucleotides and other essential cell components (CA II and CA V). Sulfonamides 47-59 carbonic anhydrase 5A Homo sapiens 400-404 10768298-2 2000 METHODS: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for CA I, CA II, CA III, CA IV, CA V, and CA VI were determined for human (HCA), rat (RCA), or mouse (MCA). Acetazolamide 50-63 carbonic anhydrase 5A Homo sapiens 102-106 11203012-3 2000 The mechanism of antitumour action with the new sulfonamides reported here is unknown, but it might involve either inhibition of several CA isozymes (such as CA IX, CA XII, CA XIV) present predominantly in tumour cell membranes, acidification of the intracellular environment as a consequence of CA inhibition, uncoupling of mitochondria and/or strong CA V inhibition, or a combination of several such mechanisms. Sulfonamides 48-60 carbonic anhydrase 5A Homo sapiens 352-356 10768298-2 2000 METHODS: The inhibition constants (Ki) of TPM and acetazolamide (AZM) for CA I, CA II, CA III, CA IV, CA V, and CA VI were determined for human (HCA), rat (RCA), or mouse (MCA). Acetazolamide 65-68 carbonic anhydrase 5A Homo sapiens 102-106 11140614-4 2000 The mechanism of antitumor action with these sulfonamides is unknown, but it might involve either inhibition of several CA isozymes (such as CA IX, CA XII, CA XIV) predominantly present in tumor cells, a reduced provision of bicarbonate for the nucleotide synthesis (mediated by carbamoyl phosphate synthetase II), the acidification of the intracellular milieu as a consequence of CA inhibition or uncoupling of mitochondria and potent CA V inhibition among others. Sulfonamides 45-57 carbonic anhydrase 5A Homo sapiens 436-440 11140614-4 2000 The mechanism of antitumor action with these sulfonamides is unknown, but it might involve either inhibition of several CA isozymes (such as CA IX, CA XII, CA XIV) predominantly present in tumor cells, a reduced provision of bicarbonate for the nucleotide synthesis (mediated by carbamoyl phosphate synthetase II), the acidification of the intracellular milieu as a consequence of CA inhibition or uncoupling of mitochondria and potent CA V inhibition among others. Bicarbonates 225-236 carbonic anhydrase 5A Homo sapiens 436-440 9805254-8 1998 Based on these measurements, we calculated the arteriovenous oxygen difference (c(A-V)O2 difference) during exercise in individual patients using Fick"s equation. Oxygen 61-67 carbonic anhydrase 5A Homo sapiens 80-88 10409679-10 1999 Similar to CA VA, CA VB is a "low activity" enzyme with a sensitivity to acetazolamide. Acetazolamide 73-86 carbonic anhydrase 5A Homo sapiens 11-16 10082753-9 1999 We propose that mitochondrial CA V participates in the detoxification of ammonia produced in the gastrointestinal tract by providing bicarbonate to carbamyl phosphate synthetase I. Ammonia 73-80 carbonic anhydrase 5A Homo sapiens 30-34 10082753-9 1999 We propose that mitochondrial CA V participates in the detoxification of ammonia produced in the gastrointestinal tract by providing bicarbonate to carbamyl phosphate synthetase I. Bicarbonates 133-144 carbonic anhydrase 5A Homo sapiens 30-34 9805254-9 1998 The c(A-V)O2 difference was markedly increased in severe heart failure during the warm-up stage, but between the end of warm-up and the AT point, it remained at the same level as that of group H. These results suggest the presence of a unique mechanism regulating the c(A-V)O2 difference in severe heart failure patients, activation of which may, at least during mild exercise, contribute to efficient oxygen delivery to the peripheral tissues thus compensating for the jeopardized exercise tolerance in those patients. Oxygen 402-408 carbonic anhydrase 5A Homo sapiens 4-12 9805254-9 1998 The c(A-V)O2 difference was markedly increased in severe heart failure during the warm-up stage, but between the end of warm-up and the AT point, it remained at the same level as that of group H. These results suggest the presence of a unique mechanism regulating the c(A-V)O2 difference in severe heart failure patients, activation of which may, at least during mild exercise, contribute to efficient oxygen delivery to the peripheral tissues thus compensating for the jeopardized exercise tolerance in those patients. Oxygen 402-408 carbonic anhydrase 5A Homo sapiens 268-276 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 44-47 carbonic anhydrase 5A Homo sapiens 131-151 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 44-47 carbonic anhydrase 5A Homo sapiens 153-157 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 78-81 carbonic anhydrase 5A Homo sapiens 131-151 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 78-81 carbonic anhydrase 5A Homo sapiens 153-157 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. Water 211-216 carbonic anhydrase 5A Homo sapiens 131-151 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. Water 211-216 carbonic anhydrase 5A Homo sapiens 153-157 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. hydroxide ion 220-229 carbonic anhydrase 5A Homo sapiens 131-151 9398305-1 1997 Maximal turnover rates for the hydration of CO2 and the depletion of 18O from CO2 catalyzed by carbonic anhydrase III (CA III) and carbonic anhydrase V (CA V) are limited by proton transfer involving zinc-bound water or hydroxide in the active site. hydroxide ion 220-229 carbonic anhydrase 5A Homo sapiens 153-157 35635084-0 2022 Photoluminescence enhancement of orange-emitting Ca5(PO4)2SiO4:Sm3+ phosphor through charge compensation of A+ (Li+, Na+ and K+) ions for white light-emitting diodes. sm3+ phosphor 63-76 carbonic anhydrase 5A Homo sapiens 49-52 35358526-7 2022 Meanwhile, these P-composite biochar exhibited more Pb/Cd immobilization (31.3-92.3%) compared with the pristine biochar (9.5-47.2%), which was mainly due to the formation of stable precipitates Pb5(PO4)3Cl and Cd3(PO4)2, especially for Ca5(PO4)3(OH) modification. Lead 52-54 carbonic anhydrase 5A Homo sapiens 237-246 9523771-2 1997 They may be broadly recognized according to the efficiency with which they catalyze the reversible interconversion of CO2 and HCO3-, and they differ in physicochemical properties, in sensitivity to various inhibitors and in their subcellular localization; cytoplasmic (CA I, CA II, CA III, and CA VII), cell-surface membrane (CA IV), and mitochondrial (CA V) and secretory (CA VI) isoenzymes have been described. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 118-121 carbonic anhydrase 5A Homo sapiens 294-298 9523771-2 1997 They may be broadly recognized according to the efficiency with which they catalyze the reversible interconversion of CO2 and HCO3-, and they differ in physicochemical properties, in sensitivity to various inhibitors and in their subcellular localization; cytoplasmic (CA I, CA II, CA III, and CA VII), cell-surface membrane (CA IV), and mitochondrial (CA V) and secretory (CA VI) isoenzymes have been described. Bicarbonates 126-130 carbonic anhydrase 5A Homo sapiens 294-298 8356065-6 1993 The N-terminal sequence determined directly on the 30-kDa soluble CA purified from transfected COS cells indicated that processing of the precursor to mature human CA V involves removal of a 38-aa mitochondrial leader sequence. carbonyl sulfide 95-98 carbonic anhydrase 5A Homo sapiens 164-168 34677913-2 2021 Accordingly, hydroxyapatite (Ca5 (PO4 )3 (OH)), a tooth-derived material showing excellent mechanical and thermodynamic stabilities, is selected. Durapatite 13-27 carbonic anhydrase 5A Homo sapiens 29-40 35358526-3 2022 Two phosphorus materials from tailings, Ca(H2PO4)2 and Ca5(PO4)3(OH), were selected as modifier to load into biomass prior to pyrolysis. Phosphorus 4-14 carbonic anhydrase 5A Homo sapiens 55-64 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. xsm3+ 36-41 carbonic anhydrase 5A Homo sapiens 20-23 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. c5pso 43-48 carbonic anhydrase 5A Homo sapiens 20-23 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. sm3+ 49-53 carbonic anhydrase 5A Homo sapiens 20-23 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. phosphine 55-63 carbonic anhydrase 5A Homo sapiens 20-23 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. c5pso 178-183 carbonic anhydrase 5A Homo sapiens 20-23 35635084-1 2022 The orange-emitting Ca5-x(PO4)2SiO4:xSm3+ (C5PSO:Sm3+) phosphor was prepared via a simple solid-state method, and the charge compensators A+ (A = Li, Na and K) were codoped into C5PSO:Sm3+ for improving the luminescence performance. sm3+ 184-188 carbonic anhydrase 5A Homo sapiens 20-23 35543404-1 2022 OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited. Oxygen 31-37 carbonic anhydrase 5A Homo sapiens 26-30 35588279-2 2022 Herein, an enamel-like layer of nanohydroxyapatite (Ca5(PO4)3(OH), nano-HAP) is constructed on Zn anode to enhance its stability. nanohydroxyapatite 32-50 carbonic anhydrase 5A Homo sapiens 52-61 35588279-2 2022 Herein, an enamel-like layer of nanohydroxyapatite (Ca5(PO4)3(OH), nano-HAP) is constructed on Zn anode to enhance its stability. Zinc 95-97 carbonic anhydrase 5A Homo sapiens 52-61 34999029-9 2022 Furthermore, the results from the Standards, Measurements and Testing (SMT) and X-Ray Diffraction (XRD) showed that phosphorus in the AGS mainly existed in the form of inorganic phosphorus (IP) and the proportion of Ca5(PO4)3(OH) in IP was up to 92%. Phosphorus 116-126 carbonic anhydrase 5A Homo sapiens 216-225 35543404-1 2022 OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited. Oxygen 54-56 carbonic anhydrase 5A Homo sapiens 26-30 35543404-1 2022 OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited. Oxygen 195-201 carbonic anhydrase 5A Homo sapiens 26-30 35543404-1 2022 OBJECTIVES: Superior vena cava oxygen saturation (SVC O2) monitoring is well described for early detection of hemodynamic deterioration after neonatal cardiac surgery but inferior vena cava vein oxygen saturation (IVC O2) monitoring data are limited. Oxygen 195-201 carbonic anhydrase 5A Homo sapiens 185-189 35154043-0 2021 Inhibition of Biogenic Amines Formation in Fermented Foods by the Addition of Cava Lees. Amines 23-29 carbonic anhydrase 5A Homo sapiens 78-82 35626801-2 2022 We previously showed that real-time sonography was safer and faster than radiography in identifying PCVC tip location in the inferior vena cava (IVC). pcvc 100-104 carbonic anhydrase 5A Homo sapiens 139-143 35534894-0 2022 CaVbeta-subunit dependence of forward and reverse trafficking of CaV1.2 calcium channels. Calcium 72-79 carbonic anhydrase 5A Homo sapiens 0-7 35534894-1 2022 Auxiliary CaVbeta subunits interact with the pore forming CaValpha1 subunit to promote the plasma membrane expression of high voltage-activated calcium channels and to modulate the biophysical properties of Ca2+ currents. Calcium 144-151 carbonic anhydrase 5A Homo sapiens 10-17 35154043-3 2021 The aim of the current work was to investigate whether the use of cava lees can help to control biogenic amine formation in bread and fermented sausages. Amines 105-110 carbonic anhydrase 5A Homo sapiens 66-70 35154043-6 2021 In sausages spontaneously fermented and inoculated with Salmonella spp., the presence of cadaverine and putrescine diminished by 62 and 78%, respectively, due to the addition of cava lees. Cadaverine 89-99 carbonic anhydrase 5A Homo sapiens 178-182 35154043-6 2021 In sausages spontaneously fermented and inoculated with Salmonella spp., the presence of cadaverine and putrescine diminished by 62 and 78%, respectively, due to the addition of cava lees. Putrescine 104-114 carbonic anhydrase 5A Homo sapiens 178-182 35154043-7 2021 The addition of cava lees phenolic extract also showed an anti-aminogenic effect (21% for cadaverine and 40% for putrescine), although in a lesser extent than cava lees. Cadaverine 90-100 carbonic anhydrase 5A Homo sapiens 16-20 35154043-7 2021 The addition of cava lees phenolic extract also showed an anti-aminogenic effect (21% for cadaverine and 40% for putrescine), although in a lesser extent than cava lees. Putrescine 113-123 carbonic anhydrase 5A Homo sapiens 16-20 35154043-8 2021 Cava lees and their phenolic extract were shown to be an effective strategy to control the undesirable accumulation of high levels of biogenic amines during the production of fermented products. Amines 143-149 carbonic anhydrase 5A Homo sapiens 0-4 34980202-0 2022 Cavbeta surface charged residues contribute to the regulation of neuronal calcium channels. Calcium 74-81 carbonic anhydrase 5A Homo sapiens 0-7 34047722-0 2021 Early Goal-Directed Therapy With and Without Intermittent Superior Vena Cava Oxygen Saturation Monitoring in Pediatric Septic Shock: A Randomized Controlled Trial. Oxygen 77-83 carbonic anhydrase 5A Homo sapiens 72-76 33890356-0 2021 CaV beta controls the endocytic turnover of CaV 1.2 L-type calcium channel. Calcium 59-66 carbonic anhydrase 5A Homo sapiens 0-8 33890356-11 2021 Thus, CaV beta promotes fast transport speed along anterograde trafficking and acts as a molecular switch controlling the endocytic turnover of L-type calcium channels. Calcium 151-158 carbonic anhydrase 5A Homo sapiens 6-14 33450641-7 2021 The linear combination approach & cross-checking among XANES results proposed that Ca5(OH)(PO4)2, Ca3(PO4)2 and Zn3(PO4)2 are potentially major chemical compounds in raw ash particles, when combined with the STEM-XEDS results. xanes 55-60 carbonic anhydrase 5A Homo sapiens 83-86 32530547-8 2021 Optimal QTc cut-off for prediction of CA/VA was >=480ms. qtc 8-11 carbonic anhydrase 5A Homo sapiens 38-43 33467439-2 2021 This paper reports the creation of hydroxyapatite/polyester nanografts by "graft-from" polymerization of d,l-lactide with [Ca5(OH)(PO4)3]2 as the initiator and tin(II)-2-ethylhexanoate as the catalyst. d,l-lactide 105-116 carbonic anhydrase 5A Homo sapiens 123-126 33183174-3 2022 In this work, we have developed C2, and C4 substituted oxazole-5(4H)-one derivatives as a new scaffold for the selective inhibition of human carbonic anhydrase VA (hCAVA). substituted oxazole-5(4h)-one 43-72 carbonic anhydrase 5A Homo sapiens 164-169 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. cacro4 18-24 carbonic anhydrase 5A Homo sapiens 150-153 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. Chromium 20-22 carbonic anhydrase 5A Homo sapiens 67-70 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. Chromium 20-22 carbonic anhydrase 5A Homo sapiens 150-153 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. Chromium 71-73 carbonic anhydrase 5A Homo sapiens 67-70 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. Chromium 71-73 carbonic anhydrase 5A Homo sapiens 150-153 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. tris(1,10-phenanthroline)chromium(III) chloride 274-281 carbonic anhydrase 5A Homo sapiens 67-70 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. tris(1,10-phenanthroline)chromium(III) chloride 274-281 carbonic anhydrase 5A Homo sapiens 150-153 32805661-4 2021 It was found that CaCrO4 reacted with CaO and formed a new product Ca5(CrO4)3O0.5 at temperature range of 800 and 1000 C. The valence state of Cr in Ca5(CrO4)3O0.5 is determined to be +5 b y XPS analysis, and the color for new formed Cr(V) is observed in green, similar to Cr(III) compounds. cacro4 18-24 carbonic anhydrase 5A Homo sapiens 67-70 33183174-7 2022 The present work opens a platform for the use of oxazole-5(4H)-ones and holds promise for further refinement of potent and selective hCAVA inhibitors. oxazole-5(4h)-ones 49-67 carbonic anhydrase 5A Homo sapiens 133-138 31914618-11 2020 Furthermore, we demonstrate that Cav-a vesicles show polarized trafficking and localize at the luminal membrane during notochord lumenogenesis. Phenobarbital 95-102 carbonic anhydrase 5A Homo sapiens 33-36 32814116-7 2020 Like CaVbeta, Srobeta prevents fast degradation of total CaV2.3 proteins in cycloheximide assays. Cycloheximide 76-89 carbonic anhydrase 5A Homo sapiens 5-12 32612224-5 2020 Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. Durapatite 121-136 carbonic anhydrase 5A Homo sapiens 138-147 32612224-5 2020 Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. Magnesium 250-259 carbonic anhydrase 5A Homo sapiens 138-147 32612224-5 2020 Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. Sodium 284-290 carbonic anhydrase 5A Homo sapiens 138-147 32612224-5 2020 Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. Fluorides 292-300 carbonic anhydrase 5A Homo sapiens 138-147 32612224-5 2020 Here we show, using atomic-scale quantitative imaging and correlative spectroscopies, that the nanoscale crystallites of hydroxylapatite (Ca5(PO4)3(OH)), which are the fundamental building blocks of enamel, comprise two nanometric layers enriched in magnesium flanking a core rich in sodium, fluoride and carbonate ions; this sandwich core is surrounded by a shell with lower concentration of substitutional defects. Carbonates 305-314 carbonic anhydrase 5A Homo sapiens 138-147 32092307-6 2020 The C11-functionalized cephalostatin 1 analogues 5 and 6 (CA5 and CA6) were found to exhibit cytotoxic activity against K-562 leukemia cells, MCF-7 breast cancer cells and DU-145 prostate cancer cells, while the remaining four analogues did not show anti-tumor activities against any of the cell lines. cephalostatin 23-36 carbonic anhydrase 5A Homo sapiens 58-61 32092307-8 2020 CA5 and CA6 are promising anticancer agents due to their low GI50, the remarkable apoptosis pathway they induce which can overcome chemoresistance, and their very low toxicity to normal cells making them cephalostatin 1 utilizable alternatives. cephalostatin 204-217 carbonic anhydrase 5A Homo sapiens 0-3 32195221-4 2020 Here, we adopt a targeted approach based on a reverse-affinity procedure to identify the ability of chromomycins A5 (CA5) and A6 (CA6) to interact with TBX2. Chromomycins 100-112 carbonic anhydrase 5A Homo sapiens 117-120 31479791-3 2019 CASE DESCRIPTION: We present a case of a persistent left-sided inferior vena cava (IVC) affecting the side of approach in a patient undergoing lumbar interbody fusion through an oblique pre-psoas retroperitoneal approach. psoas 190-195 carbonic anhydrase 5A Homo sapiens 77-81 30734592-4 2019 The new amino acid benzothiazole conjugates found to be more effective against hCA V and hCA II inhibition. amino acid benzothiazole 8-32 carbonic anhydrase 5A Homo sapiens 79-84 30738161-6 2019 The removal percentages of arsenic with CA-5 and CAP-5 hollow fiber membrane was 34% and 41% with arsenic removal permeability was 44.42 L/m2h bar and 40.11 L/m2h bar respectively. Arsenic 27-34 carbonic anhydrase 5A Homo sapiens 40-44 31403402-0 2019 A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVbeta subunits. Calcium 23-30 carbonic anhydrase 5A Homo sapiens 98-105 30738161-7 2019 The increased pure water permeability for CA-5 and CAP-5 hollow fiber membrane was 61.47 L/m2h bar and 69.60 L/m2 h bar, respectively. Water 19-24 carbonic anhydrase 5A Homo sapiens 42-46 29129580-7 2018 Cavbeta antisense reduces T-cell receptor-driven calcium responses and cytokine production by mouse and human TH2 cells with no effect on TH1 cells. Calcium 49-56 carbonic anhydrase 5A Homo sapiens 0-7 30216643-0 2018 Near-infrared emitting Ca5 (PO4 )3 Cl:Eu2+ ,Nd3+ phosphor for modification of the solar spectrum. europium(2+) 38-42 carbonic anhydrase 5A Homo sapiens 23-26 30216643-0 2018 Near-infrared emitting Ca5 (PO4 )3 Cl:Eu2+ ,Nd3+ phosphor for modification of the solar spectrum. phosphine 49-57 carbonic anhydrase 5A Homo sapiens 23-26 32477731-0 2019 Direct His-bundle Pacing in a Patient with a Persistent Left Superior Vena Cava. Histidine 7-10 carbonic anhydrase 5A Homo sapiens 75-79 31574542-1 2019 Particulate hydroxyapatite, Ca5 (PO4)3 (OH), shows a good biocompatibility and is used as a biomimetic ingredient in dental care formulations due to its similarity to human enamel. Hydroxyapatites 12-26 carbonic anhydrase 5A Homo sapiens 28-31 30634721-3 2019 In this paper, a previously optimized method based on reversed phase high performance liquid chromatography (HPLC) with ultraviolet/visible (UV/Vis) detection has been applied to determine polyphenols in cava wines. Polyphenols 189-200 carbonic anhydrase 5A Homo sapiens 204-208 29129580-5 2018 METHODS: We used Cavbeta antisense oligonucleotides to knock down Cavbeta and gabapentin, a drug that binds to and inhibits alpha2delta1 and alpha2delta2, to test their effects on TH2 functions and their capacity to reduce allergic airway inflammation. Oligonucleotides 35-51 carbonic anhydrase 5A Homo sapiens 66-73 29129580-5 2018 METHODS: We used Cavbeta antisense oligonucleotides to knock down Cavbeta and gabapentin, a drug that binds to and inhibits alpha2delta1 and alpha2delta2, to test their effects on TH2 functions and their capacity to reduce allergic airway inflammation. Gabapentin 78-88 carbonic anhydrase 5A Homo sapiens 17-24 29129580-10 2018 CONCLUSIONS: These results stress the role of Cavbeta and alpha2delta2 auxiliary subunits in the stability and activation of Cav1.2 channels in TH2 lymphocytes both in vitro and in vivo, as demonstrated by the beneficial effect of Cavbeta antisense and gabapentin in allergic airway inflammation. Gabapentin 253-263 carbonic anhydrase 5A Homo sapiens 46-53 29305297-3 2018 A series of chloro-substituted benzenesulfonamides bearing a heterocyclic tail, together with molecular docking, was used to build inhibitors that explore substituent influence on the binding affinity to the CA VA isoform. chloro-substituted benzenesulfonamides 12-50 carbonic anhydrase 5A Homo sapiens 208-213 28936885-3 2017 Of the 11 investigated human (h) isoforms, the widespread hCA I and II, the secreted hCA VI, as well as the cytosolic hCA XIII, and membrane-bound hCA IX and XIV were poorly activated by these amines, whereas the extracellular hCA IV, the mitochondrial enzymes hCA VA/VB, the cytosolic hCA VII, and the transmembrane isoform hCA XII were potently activated. Amines 193-199 carbonic anhydrase 5A Homo sapiens 261-270 28277280-5 2017 The remaining cytosolic (CA III, VII and XIII), membrane-anchored (CA IV), mitochondrial (CA VA, VB), transmembrane (CA XII) and secreted (CA VI) isoforms were slightly less inhibited by bortezomib compared to isoforms discussed above, with KIs ranging between 4.38 and 8.45muM. Bortezomib 187-197 carbonic anhydrase 5A Homo sapiens 90-95