PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
12154030-3	2002	We found that PEG-coated TRX-20 liposomes (TRX-20 liposomes) bound preferentially to certain CSs, such as CS B, CS D, and CS E, whereas PEG-coated liposomes lacking TRX-20 showed no significant binding to any of the glycosaminoglycans tested.	Polyethylene Glycols	14-17	cysteine sulfinic acid decarboxylase	Mus musculus	112-116
19341809-0	2009	Accessory sex glands of male mice have the ability to synthesize taurine via the cysteine sulfinate decarboxylase pathway.	Taurine	65-72	cysteine sulfinic acid decarboxylase	Mus musculus	81-113
19341809-6	2009	The taurine concentrations in the dorsolateral prostate, ventral prostate, and anterior prostate; seminal vesicle; and bulbourethral gland in terms of micromoles per gram wet weight were 6.09+/-0.67, 6.62+/-0.43, 4.14+/-0.05, 12.55+/-1.03, and 7.50+/-0.64, respectively; these values are similar to the relative expression levels of the CSD protein.	Taurine	4-11	cysteine sulfinic acid decarboxylase	Mus musculus	337-340
19341809-7	2009	These results demonstrate that CSD is expressed in the accessory sex glands of mice, and they confirm our hypothesis that male accessory sex glands are able to synthesize taurine through the CSD pathway.	Taurine	171-178	cysteine sulfinic acid decarboxylase	Mus musculus	31-34
19341809-7	2009	These results demonstrate that CSD is expressed in the accessory sex glands of mice, and they confirm our hypothesis that male accessory sex glands are able to synthesize taurine through the CSD pathway.	Taurine	171-178	cysteine sulfinic acid decarboxylase	Mus musculus	191-194
15625183-4	2005	We investigate the oligosaccharide epitope structures of these CS-D-reactive mAbs by ELISA and oligosaccharide microarrays using lipid-derivatized CS oligosaccharides.	Oligosaccharides	19-34	cysteine sulfinic acid decarboxylase	Mus musculus	63-67
15625183-4	2005	We investigate the oligosaccharide epitope structures of these CS-D-reactive mAbs by ELISA and oligosaccharide microarrays using lipid-derivatized CS oligosaccharides.	Oligosaccharides	95-110	cysteine sulfinic acid decarboxylase	Mus musculus	63-67
15625183-4	2005	We investigate the oligosaccharide epitope structures of these CS-D-reactive mAbs by ELISA and oligosaccharide microarrays using lipid-derivatized CS oligosaccharides.	Oligosaccharides	150-166	cysteine sulfinic acid decarboxylase	Mus musculus	63-67
12917413-2	2003	Oversulfated CS variants, CS-D from shark cartilage and CS-E from squid cartilage, also possess similar activities.	Chondroitin Sulfates	13-15	cysteine sulfinic acid decarboxylase	Mus musculus	26-30
16252094-1	2006	Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine, but it is still controversial whether the male reproductive organs have the function to synthesize taurine through CSD pathway.	Taurine	83-90	cysteine sulfinic acid decarboxylase	Mus musculus	0-32
16252094-1	2006	Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine, but it is still controversial whether the male reproductive organs have the function to synthesize taurine through CSD pathway.	Taurine	83-90	cysteine sulfinic acid decarboxylase	Mus musculus	34-37
16252094-1	2006	Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine, but it is still controversial whether the male reproductive organs have the function to synthesize taurine through CSD pathway.	Taurine	191-198	cysteine sulfinic acid decarboxylase	Mus musculus	34-37
16252094-6	2006	These results suggest that male genital organs have the function to produce taurine through the CSD pathway, although quantifying the relation of CSD expression to taurine synthesis and the exact functions of taurine in male genital organs still need to be elucidated in future studies.	Taurine	76-83	cysteine sulfinic acid decarboxylase	Mus musculus	96-99
16252094-6	2006	These results suggest that male genital organs have the function to produce taurine through the CSD pathway, although quantifying the relation of CSD expression to taurine synthesis and the exact functions of taurine in male genital organs still need to be elucidated in future studies.	Taurine	164-171	cysteine sulfinic acid decarboxylase	Mus musculus	146-149
16252094-6	2006	These results suggest that male genital organs have the function to produce taurine through the CSD pathway, although quantifying the relation of CSD expression to taurine synthesis and the exact functions of taurine in male genital organs still need to be elucidated in future studies.	Taurine	164-171	cysteine sulfinic acid decarboxylase	Mus musculus	146-149
33253877-7	2021	Phe94 was predicted to affect substrate specificity, and its mutation to serine altered both the catalytic properties of CSAD and its stability.	Serine	73-79	cysteine sulfinic acid decarboxylase	Mus musculus	121-125
12154030-3	2002	We found that PEG-coated TRX-20 liposomes (TRX-20 liposomes) bound preferentially to certain CSs, such as CS B, CS D, and CS E, whereas PEG-coated liposomes lacking TRX-20 showed no significant binding to any of the glycosaminoglycans tested.	3,5-dipentadecyloxybenzamidine hydrochloride	25-31	cysteine sulfinic acid decarboxylase	Mus musculus	112-116
9452446-8	1998	Eight octasaccharide fractions were isolated from CS-D after partial digestion with bacterial chondroitinase ABC by means of gel filtration chromatography and anion-exchange high performance liquid chromotography to investigate the frequency and the arrangement of the A-D tetrasaccharide unit in the polymer sequence.	Octasaccharide	6-20	cysteine sulfinic acid decarboxylase	Mus musculus	50-54
9452446-12	1998	It remains to be determined whether such characteristic hexasaccharide sequences present in shark cartilage CS-D serve as functional domain structures recognized by some protein ligands.	hexasaccharide	56-70	cysteine sulfinic acid decarboxylase	Mus musculus	108-112
11997111-1	2002	Cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine which is essential to biological processes such as development of the brain and eye, reproduction, osmoregulation as well as the anti-inflammatory activity of leukocytes.	Taurine	91-98	cysteine sulfinic acid decarboxylase	Mus musculus	0-36
11997111-1	2002	Cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine which is essential to biological processes such as development of the brain and eye, reproduction, osmoregulation as well as the anti-inflammatory activity of leukocytes.	Taurine	91-98	cysteine sulfinic acid decarboxylase	Mus musculus	38-41
11600666-2	2001	Experiments were performed in halothane-anesthetized mice, with three different locations aligned 1.5 mm from the midline used for either KCl elicitation of CSD or the recording of its propagation.	Potassium Chloride	138-141	cysteine sulfinic acid decarboxylase	Mus musculus	157-160
35237165-11	2022	Cysteine sulfinic acid decarboxylase (CSAD), the rate-limiting enzyme of taurine generation, significantly increased along with inhibiting endothelial cell apoptosis after treatment of EDA.	Taurine	73-80	cysteine sulfinic acid decarboxylase	Mus musculus	0-36
35237165-11	2022	Cysteine sulfinic acid decarboxylase (CSAD), the rate-limiting enzyme of taurine generation, significantly increased along with inhibiting endothelial cell apoptosis after treatment of EDA.	Taurine	73-80	cysteine sulfinic acid decarboxylase	Mus musculus	38-42
35237165-12	2022	Thus, CSAD, as the possible new therapeutic target of EDA, was selected and validated by Western blot and immunofluorescence.	Edaravone	54-57	cysteine sulfinic acid decarboxylase	Mus musculus	6-10
35237165-13	2022	Together, this study provided the metabolite signatures and identified CSAD as an unrecognized therapeutic intervention for EDA in the treatment of ischemic stroke via inhibiting brain endothelial cell apoptosis.	Edaravone	124-127	cysteine sulfinic acid decarboxylase	Mus musculus	71-75
6822523-2	1983	L-Cysteinesulfinate, a quantitatively important catabolite of L-cysteine, is a substrate of both cysteinesulfinate decarboxylase and glutamate-oxaloacetate transaminase.	cysteine sulfinic acid	0-19	cysteine sulfinic acid decarboxylase	Mus musculus	97-128
6822523-2	1983	L-Cysteinesulfinate, a quantitatively important catabolite of L-cysteine, is a substrate of both cysteinesulfinate decarboxylase and glutamate-oxaloacetate transaminase.	Cysteine	62-72	cysteine sulfinic acid decarboxylase	Mus musculus	97-128
6822523-15	1983	Highly purified cysteinesulfinate decarboxylase is also shown to decarboxylate L-aspartate to beta-alanine and, very slowly, glutamate to gamma-aminobutyrate.	Aspartic Acid	79-90	cysteine sulfinic acid decarboxylase	Mus musculus	16-47
6822523-15	1983	Highly purified cysteinesulfinate decarboxylase is also shown to decarboxylate L-aspartate to beta-alanine and, very slowly, glutamate to gamma-aminobutyrate.	beta-Alanine	94-106	cysteine sulfinic acid decarboxylase	Mus musculus	16-47
6822523-15	1983	Highly purified cysteinesulfinate decarboxylase is also shown to decarboxylate L-aspartate to beta-alanine and, very slowly, glutamate to gamma-aminobutyrate.	Glutamic Acid	125-134	cysteine sulfinic acid decarboxylase	Mus musculus	16-47
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	144-180
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	182-190
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	cysteine sulfinic acid	144-166	cysteine sulfinic acid decarboxylase	Mus musculus	182-190
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	hypotaurine	277-288	cysteine sulfinic acid decarboxylase	Mus musculus	144-180
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	Cysteic Acid	296-308	cysteine sulfinic acid decarboxylase	Mus musculus	144-180
6955797-1	1982	Taurine neurons in the cerebellum of rabbit, rat, and mouse were localized at the light microscope level by using polyclonal antibodies against cysteine sulfinic acid decarboxylase (CSADCase; EC 4.1.1.29), the enzyme responsible for the conversion of cysteine sulfinic acid to hypotaurine and of cysteic acid to taurine.	Taurine	281-288	cysteine sulfinic acid decarboxylase	Mus musculus	144-180
33877450-1	2021	In this study, we examined neuronal excitability and skeletal muscle physiology and histology in homozygous knockout mice lacking cysteine sulfonic acid decarboxylase (CSAD-KO).	S-sulphocysteine	130-152	cysteine sulfinic acid decarboxylase	Mus musculus	168-172
33877450-17	2021	We suggest that taurine deficiency leads to alterations in the GABAergic system that contribute to the enhanced stretch reflex in CSAD-KO mice through biochemical mechanisms that involve alterations not only at the spinal level but also at the cortical level.	Taurine	16-23	cysteine sulfinic acid decarboxylase	Mus musculus	130-134
33253877-9	2021	The structure of apo-CSAD indicates that the active site gets more ordered upon internal aldimine formation.	aldimine	89-97	cysteine sulfinic acid decarboxylase	Mus musculus	21-25
29871716-0	2018	HNF4alpha Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice.	Taurine	43-50	cysteine sulfinic acid decarboxylase	Mus musculus	20-24
32820455-9	2021	E2 also downregulates myometrial cysteinesulfinic acid decarboxylase (CSAD) and decreases myometrial biochemical synthesis of the gaso-transmitter hydrogen sulfide (H2S).	Estradiol	0-2	cysteine sulfinic acid decarboxylase	Mus musculus	33-68
32820455-9	2021	E2 also downregulates myometrial cysteinesulfinic acid decarboxylase (CSAD) and decreases myometrial biochemical synthesis of the gaso-transmitter hydrogen sulfide (H2S).	Estradiol	0-2	cysteine sulfinic acid decarboxylase	Mus musculus	70-74
31468456-2	2019	Since taurine is produced by cysteine sulfinic acid decarboxylase (CSAD) in the liver and kidney, taurine-deficient mice without CSAD have been investigated for abnormal physiological functions such as retinal development, immune, pancreatic and liver function.	Taurine	6-13	cysteine sulfinic acid decarboxylase	Mus musculus	29-65
31468456-2	2019	Since taurine is produced by cysteine sulfinic acid decarboxylase (CSAD) in the liver and kidney, taurine-deficient mice without CSAD have been investigated for abnormal physiological functions such as retinal development, immune, pancreatic and liver function.	Taurine	6-13	cysteine sulfinic acid decarboxylase	Mus musculus	67-71
31468456-4	2019	In neonatal brains of homozygous CSAD knockout mice (HO), taurine was reduced by 85%, compared to wild-type mice (WT).	Taurine	58-65	cysteine sulfinic acid decarboxylase	Mus musculus	33-37
31468461-8	2019	Cysteine sulfonic acid decarboxylase (CSAD) was first identified in the liver and is thought to be the rate-limiting enzyme in taurine biosynthesis.	Taurine	127-134	cysteine sulfinic acid decarboxylase	Mus musculus	38-42
31468461-10	2019	Homozygous knockout mice lacking CSAD (CSAD-KO) have very reduced taurine content and show severe functional histopathology in the visual system, skeletal system, heart, pancreas and brain.	Taurine	66-73	cysteine sulfinic acid decarboxylase	Mus musculus	33-37
31468461-10	2019	Homozygous knockout mice lacking CSAD (CSAD-KO) have very reduced taurine content and show severe functional histopathology in the visual system, skeletal system, heart, pancreas and brain.	Taurine	66-73	cysteine sulfinic acid decarboxylase	Mus musculus	39-46
29871716-0	2018	HNF4alpha Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice.	Bile Acids and Salts	65-74	cysteine sulfinic acid decarboxylase	Mus musculus	20-24
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	Cysteine	39-47	cysteine sulfinic acid decarboxylase	Mus musculus	109-145
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	Cysteine	39-47	cysteine sulfinic acid decarboxylase	Mus musculus	147-151
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	cysteine sulfinic acid	51-73	cysteine sulfinic acid decarboxylase	Mus musculus	109-145
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	cysteine sulfinic acid	51-73	cysteine sulfinic acid decarboxylase	Mus musculus	147-151
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	hypotaurine	156-167	cysteine sulfinic acid decarboxylase	Mus musculus	109-145
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	hypotaurine	156-167	cysteine sulfinic acid decarboxylase	Mus musculus	147-151
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	Taurine	160-167	cysteine sulfinic acid decarboxylase	Mus musculus	109-145
29871716-1	2018	Cysteine dioxygenase 1 (CDO1) converts cysteine to cysteine sulfinic acid, which can be further converted by cysteine sulfinic acid decarboxylase (CSAD) to hypotaurine for taurine production.	Taurine	160-167	cysteine sulfinic acid decarboxylase	Mus musculus	147-151
29871716-5	2018	The mechanisms of bile acid and farnesoid X receptor (FXR) regulation of hepatic CSAD expression were studied in mice and hepatocytes.	Bile Acids and Salts	18-27	cysteine sulfinic acid decarboxylase	Mus musculus	81-85
29871716-8	2018	Consistent with this model, cholic acid feeding, obeticholic acid administration, and liver HNF4alpha knockdown reduced hepatic CSAD expression, while liver SHP knockout and apical sodium-dependent bile acid transporter (ASBT) inhibitor treatment induced hepatic CSAD expression in mice.	Cholic Acid	28-39	cysteine sulfinic acid decarboxylase	Mus musculus	128-132
29871716-8	2018	Consistent with this model, cholic acid feeding, obeticholic acid administration, and liver HNF4alpha knockdown reduced hepatic CSAD expression, while liver SHP knockout and apical sodium-dependent bile acid transporter (ASBT) inhibitor treatment induced hepatic CSAD expression in mice.	obeticholic acid	49-65	cysteine sulfinic acid decarboxylase	Mus musculus	128-132
29871716-12	2018	Bile acids and cytokines repress hepatic CSAD, which closely couples taurine production to bile acid synthesis in mice.	Bile Acids and Salts	0-10	cysteine sulfinic acid decarboxylase	Mus musculus	41-45
29871716-12	2018	Bile acids and cytokines repress hepatic CSAD, which closely couples taurine production to bile acid synthesis in mice.	Taurine	69-76	cysteine sulfinic acid decarboxylase	Mus musculus	41-45
29871716-12	2018	Bile acids and cytokines repress hepatic CSAD, which closely couples taurine production to bile acid synthesis in mice.	Bile Acids and Salts	91-100	cysteine sulfinic acid decarboxylase	Mus musculus	41-45
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Taurine	47-54	cysteine sulfinic acid decarboxylase	Mus musculus	14-21
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Taurine	47-54	cysteine sulfinic acid decarboxylase	Mus musculus	26-33
28849474-1	2017	Taurine deficient mice lacking cysteine sulfinic acid decarboxylase (CSAD KO) were developed for investigating the various physiological roles of taurine including the development of the brain and eye as well as immune function.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	31-67
28849474-9	2017	Superoxide anion production in activated PMN from CSAD KO homozygotes (HO) was not significantly different from wild-type (WT) with and without 25 mM taurine.	Superoxides	0-16	cysteine sulfinic acid decarboxylase	Mus musculus	50-54
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	91-98	cysteine sulfinic acid decarboxylase	Mus musculus	14-21
28849474-1	2017	Taurine deficient mice lacking cysteine sulfinic acid decarboxylase (CSAD KO) were developed for investigating the various physiological roles of taurine including the development of the brain and eye as well as immune function.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	69-73
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	91-98	cysteine sulfinic acid decarboxylase	Mus musculus	26-33
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	151-158	cysteine sulfinic acid decarboxylase	Mus musculus	14-21
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	151-158	cysteine sulfinic acid decarboxylase	Mus musculus	26-33
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	151-158	cysteine sulfinic acid decarboxylase	Mus musculus	14-21
28849478-5	2017	We found that CSAD-KO and CSAD-KO treated with taurine were slightly hypoglycemic prior to glucose injection and showed a significantly reduced plasma glucose at 30, 60 and 120 min post-glucose injection, compared to WT.	Glucose	151-158	cysteine sulfinic acid decarboxylase	Mus musculus	26-33
28849478-6	2017	While glucose homeostasis in CSAD-KO was significantly different compared to WT, CSAD-KO supplemented with taurine was without effect.	Glucose	6-13	cysteine sulfinic acid decarboxylase	Mus musculus	29-36
26481005-7	2016	Likewise, CSAD abundance was not affected by taurine supplementation of primary hepatocytes, although it was robustly upregulated in liver of Cdo1-null and Csad-null mice and lowered to wild-type levels by dietary taurine supplementation.	Taurine	214-221	cysteine sulfinic acid decarboxylase	Mus musculus	10-14
28849475-0	2017	A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Taurine Distribution in Various Tissues With and Without Taurine Supplementation.	Taurine	62-69	cysteine sulfinic acid decarboxylase	Mus musculus	8-44
28849475-0	2017	A Novel Cysteine Sulfinic Acid Decarboxylase Knock-Out Mouse: Taurine Distribution in Various Tissues With and Without Taurine Supplementation.	Taurine	119-126	cysteine sulfinic acid decarboxylase	Mus musculus	8-44
28849475-2	2017	In order to understand the physiological role, we developed taurine deficient mice deleting a rate-liming enzyme, cysteine sulfinic acid decarboxylase (CSAD) for biosynthesis of taurine.	Taurine	60-67	cysteine sulfinic acid decarboxylase	Mus musculus	114-150
28849475-2	2017	In order to understand the physiological role, we developed taurine deficient mice deleting a rate-liming enzyme, cysteine sulfinic acid decarboxylase (CSAD) for biosynthesis of taurine.	Taurine	60-67	cysteine sulfinic acid decarboxylase	Mus musculus	152-156
28849475-2	2017	In order to understand the physiological role, we developed taurine deficient mice deleting a rate-liming enzyme, cysteine sulfinic acid decarboxylase (CSAD) for biosynthesis of taurine.	Taurine	178-185	cysteine sulfinic acid decarboxylase	Mus musculus	114-150
28849475-2	2017	In order to understand the physiological role, we developed taurine deficient mice deleting a rate-liming enzyme, cysteine sulfinic acid decarboxylase (CSAD) for biosynthesis of taurine.	Taurine	178-185	cysteine sulfinic acid decarboxylase	Mus musculus	152-156
28849475-5	2017	Taurine concentrations in the liver and kidney from homozygotes of CSAD KO (HO), in which CSAD level is high, were 90% and 70% lower than WT, respectively.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	67-71
28849475-5	2017	Taurine concentrations in the liver and kidney from homozygotes of CSAD KO (HO), in which CSAD level is high, were 90% and 70% lower than WT, respectively.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	90-94
28849475-6	2017	Taurine concentrations in the brain, spleen and lung, where CSAD level is low, were 21%, 20% and 28% lower than WT, respectively.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	60-64
26481005-8	2016	The mechanism by which taurine status affects hepatic CSAD and BHMT expression appears to be complex and to require factors outside of hepatocytes.	Taurine	23-30	cysteine sulfinic acid decarboxylase	Mus musculus	54-58
24891521-6	2014	Regulatory changes in CDO and CSAD expression were proportional to homocysteine elevation, indicating a possible threshold effect.	Homocysteine	67-79	cysteine sulfinic acid decarboxylase	Mus musculus	30-34
26327310-7	2015	Cysteine sulfinic acid was the preferred substrate for both mouse CSAD and GADL1, although both enzymes also decarboxylated cysteic acid and aspartate.	cysteine sulfinic acid	0-22	cysteine sulfinic acid decarboxylase	Mus musculus	66-70
26327310-7	2015	Cysteine sulfinic acid was the preferred substrate for both mouse CSAD and GADL1, although both enzymes also decarboxylated cysteic acid and aspartate.	Cysteic Acid	124-136	cysteine sulfinic acid decarboxylase	Mus musculus	66-70
26327310-7	2015	Cysteine sulfinic acid was the preferred substrate for both mouse CSAD and GADL1, although both enzymes also decarboxylated cysteic acid and aspartate.	Aspartic Acid	141-150	cysteine sulfinic acid decarboxylase	Mus musculus	66-70
25645459-3	2015	Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine.	Taurine	83-90	cysteine sulfinic acid decarboxylase	Mus musculus	0-32
25645459-3	2015	Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine.	Taurine	83-90	cysteine sulfinic acid decarboxylase	Mus musculus	34-37
25645459-12	2015	These results suggest that the major salivary glands of male mice produce taurine through the CSD pathway, and the synthesis of taurine might be related to sodium reabsorption in the salivary glands.	Taurine	74-81	cysteine sulfinic acid decarboxylase	Mus musculus	94-97
25394658-0	2015	Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-alpha in female mice liver.	Estradiol	0-9	cysteine sulfinic acid decarboxylase	Mus musculus	46-82
25394658-0	2015	Estradiol decreases taurine level by reducing cysteine sulfinic acid decarboxylase via the estrogen receptor-alpha in female mice liver.	Taurine	20-27	cysteine sulfinic acid decarboxylase	Mus musculus	46-82
25394658-1	2015	Cysteine sulfinic acid decarboxylase (CSAD) and cysteine dioxygenase (CDO) are two rate-limiting enzymes in taurine de novo synthesis, and their expressions are associated with estrogen concentration.	Taurine	108-115	cysteine sulfinic acid decarboxylase	Mus musculus	0-36
25394658-1	2015	Cysteine sulfinic acid decarboxylase (CSAD) and cysteine dioxygenase (CDO) are two rate-limiting enzymes in taurine de novo synthesis, and their expressions are associated with estrogen concentration.	Taurine	108-115	cysteine sulfinic acid decarboxylase	Mus musculus	38-42
25394658-5	2015	The results showed that E2 decreased taurine level in the serum and the cultured cells by inhibiting CSAD and CDO expressions.	Taurine	37-44	cysteine sulfinic acid decarboxylase	Mus musculus	101-105
24033844-2	2014	We hypothesized that hepatic cysteine sulfinic acid decarboxylase (CSAD) (a key enzyme in taurine synthesis) is regulated by bile acids (BA).	Taurine	90-97	cysteine sulfinic acid decarboxylase	Mus musculus	67-71
24033844-2	2014	We hypothesized that hepatic cysteine sulfinic acid decarboxylase (CSAD) (a key enzyme in taurine synthesis) is regulated by bile acids (BA).	Bile Acids and Salts	125-135	cysteine sulfinic acid decarboxylase	Mus musculus	67-71
24033844-2	2014	We hypothesized that hepatic cysteine sulfinic acid decarboxylase (CSAD) (a key enzyme in taurine synthesis) is regulated by bile acids (BA).	Bile Acids and Salts	137-139	cysteine sulfinic acid decarboxylase	Mus musculus	67-71
24033844-8	2014	RESULTS: Mice supplemented with dietary cholate exhibited reduced hepatic CSAD mRNA while those receiving cholestyramine exhibited increased mRNA.	Cholates	40-47	cysteine sulfinic acid decarboxylase	Mus musculus	74-78
24033844-10	2014	Hepatic hypotaurine concentration (the product of CSAD) was higher in Shp-/- mice with a corresponding increase in serum taurine conjugated BA.	Taurine	12-19	cysteine sulfinic acid decarboxylase	Mus musculus	50-54
24639894-3	2014	HPLC indicated an 83% decrease of taurine concentration in the plasma of CSAD(-/-).	Taurine	34-41	cysteine sulfinic acid decarboxylase	Mus musculus	73-77
24639894-5	2014	Taurine concentrations in G3 CSAD(-/-) born from G2 CSAD(-/-) treated with taurine in the drinking water were restored and survival rates of G3 CSAD(-/-) increased from 15% to 92%.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	29-33
24639894-5	2014	Taurine concentrations in G3 CSAD(-/-) born from G2 CSAD(-/-) treated with taurine in the drinking water were restored and survival rates of G3 CSAD(-/-) increased from 15% to 92%.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	52-56
24639894-5	2014	Taurine concentrations in G3 CSAD(-/-) born from G2 CSAD(-/-) treated with taurine in the drinking water were restored and survival rates of G3 CSAD(-/-) increased from 15% to 92%.	Taurine	0-7	cysteine sulfinic acid decarboxylase	Mus musculus	52-56
24639894-10	2014	These data indicated that CSAD KO is a good model for studying the effects of taurine deficiency and its treatment with taurine supplementation.	Taurine	78-85	cysteine sulfinic acid decarboxylase	Mus musculus	26-30