PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9749753-2	1998	The major isoform of nAChR in the brain is made up of the alpha4 and beta2 subunits and possesses a high affinity for nicotine.	Nicotine	118-126	immunoglobulin (CD79A) binding protein 1	Mus musculus	58-64
9840619-8	1998	GM6001 and UK-221,316, inhibitors of metalloproteinases, reduced alpha4 integrin-mediated transmigration and EAE induction by C19 T-cell clones.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	0-6	immunoglobulin (CD79A) binding protein 1	Mus musculus	65-71
9182849-1	1997	In situ hybridization histochemistry with radioactive cRNA probes was used to study patterns of gene expression for alpha1, alpha2, alpha4, alpha5, beta1, beta2, and gamma2 subunit mRNAs of typeAgamma aminobutyric acid (GABA(A)) receptors and for 67-kDa glutamic acid decarboxylase (GAD67) mRNA in mouse barrel cortex during the period (postnatal days 1-12; P1-P12) when thalamocortical innervation of layer IV barrels is occurring.	Aminobutyrates	201-218	immunoglobulin (CD79A) binding protein 1	Mus musculus	132-153
7876543-1	1995	We have shown previously that a 52-kDa phosphoprotein (p52) co-precipitated with Ig receptor (IgR)-associated MB-1 protein was inducibly phosphorylated by the stimulation with 12-O-tetradecanoyl-phorbol-13-acetate.	Tetradecanoylphorbol Acetate	176-213	immunoglobulin (CD79A) binding protein 1	Mus musculus	55-58
1705971-8	1991	The alpha 2 beta 2, alpha 3 beta 2, and alpha 3 beta 4 combinations were each equally sensitive to DMPP and ACh, while the alpha 2 beta 4, alpha 4 beta 2, and alpha 4 beta 4 combinations were 4-24-fold less sensitive to DMPP than to ACh.	2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide	220-224	immunoglobulin (CD79A) binding protein 1	Mus musculus	139-146
8449216-4	1993	We demonstrate that the intravenous administration of 75 micrograms of the anti-alpha-4 specific monoclonal antibodies R1-2 or PS/2 4-6 h prior to challenge significantly inhibits the efferent response of 2,4 dinitrofluorobenzene, or oxazolone-sensitized mice.	Dinitrofluorobenzene	205-229	immunoglobulin (CD79A) binding protein 1	Mus musculus	80-87
8449216-4	1993	We demonstrate that the intravenous administration of 75 micrograms of the anti-alpha-4 specific monoclonal antibodies R1-2 or PS/2 4-6 h prior to challenge significantly inhibits the efferent response of 2,4 dinitrofluorobenzene, or oxazolone-sensitized mice.	Oxazolone	234-243	immunoglobulin (CD79A) binding protein 1	Mus musculus	80-87
1705971-8	1991	The alpha 2 beta 2, alpha 3 beta 2, and alpha 3 beta 4 combinations were each equally sensitive to DMPP and ACh, while the alpha 2 beta 4, alpha 4 beta 2, and alpha 4 beta 4 combinations were 4-24-fold less sensitive to DMPP than to ACh.	2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide	220-224	immunoglobulin (CD79A) binding protein 1	Mus musculus	159-166
30552947-1	2019	The objective of the present study is to investigate the role of alpha4, alpha5, alpha6 or beta2 nAChR subunits in the antidepressant-like effect of bupropion.	Bupropion	149-158	immunoglobulin (CD79A) binding protein 1	Mus musculus	65-87
2596029-4	1989	Induction of macrophages with the synthetic inducer 10-carboxymethyl-9-acridanone resulted in small amounts of IFN alpha 2, alpha 4, and alpha 6 mRNAs and the IFN beta mRNA level was about 100-fold higher.	10-carboxymethyl-9-acridanone	52-81	immunoglobulin (CD79A) binding protein 1	Mus musculus	124-144
30552947-5	2019	Bupropion significantly decreased immobility time and increased climbing time in the alpha4, alpha6 and beta2 nAChR KO mice in comparison to WT littermates, indicating that lack of these nAChR subunits enhanced antidepressant effects of bupropion.	Bupropion	0-9	immunoglobulin (CD79A) binding protein 1	Mus musculus	85-99
30598505-2	2019	Although alpha4 integrin is known to be a potential target of reactive oxygen species (ROS)-induced cysteine glutathionylation, the physiological significance and underlying regulatory mechanism of this event remain elusive.	Reactive Oxygen Species	62-85	immunoglobulin (CD79A) binding protein 1	Mus musculus	9-15
30598505-2	2019	Although alpha4 integrin is known to be a potential target of reactive oxygen species (ROS)-induced cysteine glutathionylation, the physiological significance and underlying regulatory mechanism of this event remain elusive.	Reactive Oxygen Species	87-90	immunoglobulin (CD79A) binding protein 1	Mus musculus	9-15
30598505-3	2019	Here, using in vitro and in vivo biochemical and cell biology approaches, we show that physiological ROS-induced glutathionylation of alpha4 integrin in neutrophils increases the binding of neutrophil-associated alpha4 integrin to vascular cell adhesion molecule 1 (VCAM-1) on human endothelial cells.	Reactive Oxygen Species	101-104	immunoglobulin (CD79A) binding protein 1	Mus musculus	134-140
30598505-2	2019	Although alpha4 integrin is known to be a potential target of reactive oxygen species (ROS)-induced cysteine glutathionylation, the physiological significance and underlying regulatory mechanism of this event remain elusive.	Cysteine	100-108	immunoglobulin (CD79A) binding protein 1	Mus musculus	9-15
30598505-3	2019	Here, using in vitro and in vivo biochemical and cell biology approaches, we show that physiological ROS-induced glutathionylation of alpha4 integrin in neutrophils increases the binding of neutrophil-associated alpha4 integrin to vascular cell adhesion molecule 1 (VCAM-1) on human endothelial cells.	Reactive Oxygen Species	101-104	immunoglobulin (CD79A) binding protein 1	Mus musculus	212-218
30598505-7	2019	Taken together, our results establish ROS-elicited glutathionylation and its modulation by Grx1 as pivotal regulatory mechanisms controlling alpha4 integrin affinity and neutrophil mobilization from the bone marrow under physiological conditions.	Reactive Oxygen Species	38-41	immunoglobulin (CD79A) binding protein 1	Mus musculus	141-147
30326594-4	2018	One of these sites and an additional site were identified when isolated alpha4/beta2* nAChRs were dephosphorylated and subsequently incubated with CaMKII in vitro, while 3 phosphorylation sites were identified following incubation with protein kinase A (PKA) in vitro.	nachrs	86-92	immunoglobulin (CD79A) binding protein 1	Mus musculus	72-84
30804752-3	2019	Neuroactive steroids (NASs) are known allosteric modulators of GABAAR channel function, but recent studies from our laboratory have revealed that NASs also exert persistent metabotropic effects on the efficacy of tonic inhibition by increasing the protein kinase C (PKC)-mediated phosphorylation of the alpha4 and beta3 subunits which increase the membrane expression and boosts tonic inhibition.	Steroids	12-20	immunoglobulin (CD79A) binding protein 1	Mus musculus	303-319
30326594-5	2018	We then isolated native alpha4/beta2* nAChRs from mouse brain following acute or chronic exposure to nicotine.	Nicotine	101-109	immunoglobulin (CD79A) binding protein 1	Mus musculus	24-36
29910731-2	2018	While the role of the alpha4 and beta2 subunit containing nicotinic acetylcholine receptors (alpha4beta2*nAChRs) in mediating nicotine effects on DA release and DA neuron activity has been widely explored, less information is available on their role in the morphological adaptation of the DA system to nicotine, eventually leading to dysfunctional behaviors observed in nicotine dependence.	Nicotine	126-134	immunoglobulin (CD79A) binding protein 1	Mus musculus	22-28
28585241-0	2018	Reduced alpha4 subunit expression in alpha4+- and alpha4+- /beta2+- nicotinic acetylcholine receptors alters alpha4beta2 subtype up-regulation following chronic nicotine treatment.	Nicotine	161-169	immunoglobulin (CD79A) binding protein 1	Mus musculus	8-14
28585241-0	2018	Reduced alpha4 subunit expression in alpha4+- and alpha4+- /beta2+- nicotinic acetylcholine receptors alters alpha4beta2 subtype up-regulation following chronic nicotine treatment.	Nicotine	161-169	immunoglobulin (CD79A) binding protein 1	Mus musculus	37-58
28585241-7	2018	KEY RESULTS: Immunochemical studies confirmed that most of the [3 H]-epibatidine binding corresponds to alpha4beta2*-nAChR and that increases in binding correspond to increases in alpha4 and beta2 proteins.	epibatidine	69-80	immunoglobulin (CD79A) binding protein 1	Mus musculus	104-110
27599714-0	2016	Ouabain interactions with the alpha4 isoform of the sodium pump trigger non-classical steroid hormone signaling and integrin expression in spermatogenic cells.	Steroids	86-101	immunoglobulin (CD79A) binding protein 1	Mus musculus	30-36
29671814-2	2018	Research indicates nicotinic acetylcholine receptors containing α4 subunits (α4*nAChRs) are both impacted by stress and capable of modulating the stress response.	Adenosine Monophosphate	65-68	immunoglobulin (CD79A) binding protein 1	Mus musculus	69-76
29671814-2	2018	Research indicates nicotinic acetylcholine receptors containing α4 subunits (α4*nAChRs) are both impacted by stress and capable of modulating the stress response.	Adenosine Monophosphate	65-68	immunoglobulin (CD79A) binding protein 1	Mus musculus	92-99
29671814-2	2018	Research indicates nicotinic acetylcholine receptors containing α4 subunits (α4*nAChRs) are both impacted by stress and capable of modulating the stress response.	Adenosine Monophosphate	88-91	immunoglobulin (CD79A) binding protein 1	Mus musculus	69-76
29671814-2	2018	Research indicates nicotinic acetylcholine receptors containing α4 subunits (α4*nAChRs) are both impacted by stress and capable of modulating the stress response.	Adenosine Monophosphate	88-91	immunoglobulin (CD79A) binding protein 1	Mus musculus	92-99
29671814-3	2018	In this study, we investigated whether varenicline, a partial α4β2*nAChR agonist which reduces nicotine, alcohol and sucrose consumption, can reduce stress, a driving factor in substance use disorders.	Varenicline	39-50	immunoglobulin (CD79A) binding protein 1	Mus musculus	67-74
29671814-3	2018	In this study, we investigated whether varenicline, a partial α4β2*nAChR agonist which reduces nicotine, alcohol and sucrose consumption, can reduce stress, a driving factor in substance use disorders.	Adenosine Monophosphate	63-66	immunoglobulin (CD79A) binding protein 1	Mus musculus	67-74
29671814-3	2018	In this study, we investigated whether varenicline, a partial α4β2*nAChR agonist which reduces nicotine, alcohol and sucrose consumption, can reduce stress, a driving factor in substance use disorders.	Adenosine Monophosphate	75-78	immunoglobulin (CD79A) binding protein 1	Mus musculus	67-74
27793780-5	2017	The action of nicotine was blocked by 1muM dihydro-beta-erythroidine (DHbetaE; specific for alpha4* nAChRs), but not 10nM methyllycaconitine (MLA; specific for alpha7* nAChRs).	Nicotine	14-22	immunoglobulin (CD79A) binding protein 1	Mus musculus	92-98
27793780-5	2017	The action of nicotine was blocked by 1muM dihydro-beta-erythroidine (DHbetaE; specific for alpha4* nAChRs), but not 10nM methyllycaconitine (MLA; specific for alpha7* nAChRs).	Dihydro-beta-Erythroidine	43-68	immunoglobulin (CD79A) binding protein 1	Mus musculus	92-98
27793780-5	2017	The action of nicotine was blocked by 1muM dihydro-beta-erythroidine (DHbetaE; specific for alpha4* nAChRs), but not 10nM methyllycaconitine (MLA; specific for alpha7* nAChRs).	Dihydro-beta-Erythroidine	70-77	immunoglobulin (CD79A) binding protein 1	Mus musculus	92-98
27599714-2	2016	Here we investigate in the murine spermatogenic cell line GC-2 interactions of the alpha4 isoform with the cardiotonic steroid ouabain in signaling cascades involved in the non-classical action of steroid hormones.	Steroids	119-126	immunoglobulin (CD79A) binding protein 1	Mus musculus	83-89
27599714-7	2016	Abrogation of alpha4 isoform expression by siRNA leads to the complete suppression of all ouabain-induced signaling mentioned above, including its stimulatory effect on the expression of beta3 integrin.	Ouabain	90-97	immunoglobulin (CD79A) binding protein 1	Mus musculus	14-20
27511281-0	2016	alpha4-Containing nicotinic receptors contribute to the effects of perinatal nicotine on ventilatory and metabolic responses of neonatal mice to ambient cooling.	Nicotine	77-85	immunoglobulin (CD79A) binding protein 1	Mus musculus	0-6
27511281-2	2016	The effects of acute nicotine exposure on breathing are largely mediated by alpha4-containing nicotine acetylcholine receptors (nAChRs).	Nicotine	21-29	immunoglobulin (CD79A) binding protein 1	Mus musculus	76-82
27102349-0	2016	Vulnerability to nicotine self-administration in adolescent mice correlates with age-specific expression of alpha4* nicotinic receptors.	Nicotine	17-25	immunoglobulin (CD79A) binding protein 1	Mus musculus	108-115
27157710-1	2016	Studies with heterologous expression systems have shown that the alpha4beta2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(alpha4)2(beta2)3] or three [(alpha4)3(beta2)2] copies of the alpha subunit in the receptor pentamer) which have different pharmacological and functional properties and are differently regulated by chronic nicotine treatment.	Nicotine	376-384	immunoglobulin (CD79A) binding protein 1	Mus musculus	65-71
27157710-5	2016	For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry.	Nicotine	31-39	immunoglobulin (CD79A) binding protein 1	Mus musculus	138-144
27157710-5	2016	For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry.	Nicotine	31-39	immunoglobulin (CD79A) binding protein 1	Mus musculus	196-202
27157710-5	2016	For cortex exposure to chronic nicotine elicited an increase in receptor density measured by (3)H-epibatidine binding, an increase in the alpha4 and beta2 protein levels, and an increase in beta2/alpha4 subunit ratio, that indicates an increased proportion of receptors with the (alpha4)2(beta2)3 stoichiometry.	Nicotine	31-39	immunoglobulin (CD79A) binding protein 1	Mus musculus	196-202
27102349-5	2016	The most prevalent is the widely expressed alpha4-containing (alpha4*) subtype which mediates reward and is strongly implicated in nicotine dependence.	Nicotine	131-139	immunoglobulin (CD79A) binding protein 1	Mus musculus	62-69
27102349-10	2016	Receptor expression showed a strong positive correlation with daily nicotine dose, suggesting that alpha4* nAChR expression levels are age-specific and may contribute to the propensity to self-administer nicotine.	Nicotine	68-76	immunoglobulin (CD79A) binding protein 1	Mus musculus	99-106
27102349-10	2016	Receptor expression showed a strong positive correlation with daily nicotine dose, suggesting that alpha4* nAChR expression levels are age-specific and may contribute to the propensity to self-administer nicotine.	Nicotine	204-212	immunoglobulin (CD79A) binding protein 1	Mus musculus	99-106
25043731-1	2014	Extrasynaptic GABAA receptors, often identified as those containing both alpha4 and delta subunits, demonstrate super-sensitivity to GABA and are involved in tonic inhibitory processes regulating activity within mesolimbocortical circuitry.	gamma-Aminobutyric Acid	14-18	immunoglobulin (CD79A) binding protein 1	Mus musculus	73-89
26961950-3	2016	In midbrain dopaminergic (DA) neurons from mice containing fluorescent nAChR subunits, menthol alone increased the number of alpha4 and alpha6 nAChR subunits, but this upregulation did not occur in midbrain GABAergic neurons.	Menthol	87-94	immunoglobulin (CD79A) binding protein 1	Mus musculus	125-131
26961950-4	2016	Thus, chronic menthol produces a cell-type-selective upregulation of alpha4* nAChRs, complementing that of chronic nicotine alone, which upregulates alpha4 subunit-containing (alpha4*) nAChRs in GABAergic but not DA neurons.	Menthol	14-21	immunoglobulin (CD79A) binding protein 1	Mus musculus	69-75
26961950-4	2016	Thus, chronic menthol produces a cell-type-selective upregulation of alpha4* nAChRs, complementing that of chronic nicotine alone, which upregulates alpha4 subunit-containing (alpha4*) nAChRs in GABAergic but not DA neurons.	Menthol	14-21	immunoglobulin (CD79A) binding protein 1	Mus musculus	149-155
26961950-4	2016	Thus, chronic menthol produces a cell-type-selective upregulation of alpha4* nAChRs, complementing that of chronic nicotine alone, which upregulates alpha4 subunit-containing (alpha4*) nAChRs in GABAergic but not DA neurons.	Menthol	14-21	immunoglobulin (CD79A) binding protein 1	Mus musculus	149-155
26961950-4	2016	Thus, chronic menthol produces a cell-type-selective upregulation of alpha4* nAChRs, complementing that of chronic nicotine alone, which upregulates alpha4 subunit-containing (alpha4*) nAChRs in GABAergic but not DA neurons.	Nicotine	115-123	immunoglobulin (CD79A) binding protein 1	Mus musculus	149-155
26961950-4	2016	Thus, chronic menthol produces a cell-type-selective upregulation of alpha4* nAChRs, complementing that of chronic nicotine alone, which upregulates alpha4 subunit-containing (alpha4*) nAChRs in GABAergic but not DA neurons.	Nicotine	115-123	immunoglobulin (CD79A) binding protein 1	Mus musculus	149-155
26961950-7	2016	In neuroblastoma cells transfected with fluorescent nAChR subunits, exposure to 500 nm menthol alone also increased nAChR number and favored the formation of (alpha4)3(beta2)2 nAChRs; this contrasts with the action of nicotine itself, which favors (alpha4)2(beta2)3 nAChRs.	Menthol	87-94	immunoglobulin (CD79A) binding protein 1	Mus musculus	159-165
26961950-9	2016	Thus, menthol stabilizes lower-sensitivity alpha4* and alpha6 subunit-containing nAChRs, possibly by acting as a chemical chaperone.	Menthol	6-13	immunoglobulin (CD79A) binding protein 1	Mus musculus	43-49
25918499-6	2015	Vasoactive intestinal peptide (VIP)-expressing interneurons that selectively innervate other interneurons (VIP/IS) were excited by ACh through the activation of nicotinic receptors containing alpha4 and beta2 subunits (alpha4beta2*).	Acetylcholine	131-134	immunoglobulin (CD79A) binding protein 1	Mus musculus	192-208
23424068-5	2013	The effect was inhibited by 1 microM dihydro-beta-erythroidine (which blocks alpha4-containing nAChRs) but not by 10 nM methyllicaconitine (which blocks alpha7-containing receptors).	Dihydro-beta-Erythroidine	37-62	immunoglobulin (CD79A) binding protein 1	Mus musculus	77-83
23623333-4	2013	The pharmacodynamics for alpha4 integrin antagonism of AJM300 was investigated in mice.	AJM300	55-61	immunoglobulin (CD79A) binding protein 1	Mus musculus	25-31
23623333-6	2013	RESULTS: HCA2969 selectively inhibited the in vitro binding of alpha4 integrin (alpha4beta7/alpha4beta1) to the cell adhesion molecules.	Carotegrast	9-16	immunoglobulin (CD79A) binding protein 1	Mus musculus	63-69
23623333-11	2013	CONCLUSIONS: Oral treatment with the selective small molecule alpha4 integrin antagonist (AJM300) prevented the development of colitis and its efficacy was comparable to that of the anti-alpha4 integrin antibody.	AJM300	90-96	immunoglobulin (CD79A) binding protein 1	Mus musculus	62-68
23545467-5	2013	Recent findings in genetically engineered mice have indicated that while alpha4-containing and beta2-containing nAChRs are involved in the acquisition of nicotine self-administration and initial stages of nicotine dependence, alpha7 homomeric nAChRs appear to be involved in the later stages of nicotine dependence.	Nicotine	154-162	immunoglobulin (CD79A) binding protein 1	Mus musculus	73-79
23545467-5	2013	Recent findings in genetically engineered mice have indicated that while alpha4-containing and beta2-containing nAChRs are involved in the acquisition of nicotine self-administration and initial stages of nicotine dependence, alpha7 homomeric nAChRs appear to be involved in the later stages of nicotine dependence.	Nicotine	205-213	immunoglobulin (CD79A) binding protein 1	Mus musculus	73-79
23545467-5	2013	Recent findings in genetically engineered mice have indicated that while alpha4-containing and beta2-containing nAChRs are involved in the acquisition of nicotine self-administration and initial stages of nicotine dependence, alpha7 homomeric nAChRs appear to be involved in the later stages of nicotine dependence.	Nicotine	205-213	immunoglobulin (CD79A) binding protein 1	Mus musculus	73-79
23009282-1	2013	AIM: To compare the therapeutic effect of alpha(2) and alpha(4) integrin-blocking antibodies to conventional inflammatory bowel disease drugs methotrexate, 5-aminosalicylic acid and azathioprine in the dextran sulphate sodium mouse colitis model.	dextran sulphate sodium	202-225	immunoglobulin (CD79A) binding protein 1	Mus musculus	42-63
22177524-9	2012	ERK1/2 phosphorylation was rapidly induced by isoproterenol (by 9.5 +- 2.4-fold) and morphine (22 +- 2.2-fold) in G(alphas) -transfected cells; mutations of alpha3/beta5 and alpha4/beta6 did not affect the pattern or extent of mitogen-activated protein kinase activation.	Isoproterenol	46-59	immunoglobulin (CD79A) binding protein 1	Mus musculus	174-186
22396410-5	2012	We detected evoked dopamine release using fast-scan cyclic voltammetry at carbon-fiber microelectrodes in striatal slices from mice with deletions of alpha4, alpha5, alpha6, or beta3 subunits.	Dopamine	19-27	immunoglobulin (CD79A) binding protein 1	Mus musculus	150-182
21977012-0	2011	Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in alpha4 Subunit Knockout Mice.	Ethanol	77-84	immunoglobulin (CD79A) binding protein 1	Mus musculus	88-94
21977012-2	2011	The alpha4 and delta subunits co-assemble into GABA(A)Rs which are relatively highly expressed at extrasynaptic locations in the dentate gyrus where they mediate tonic inhibition.	gamma-Aminobutyric Acid	47-51	immunoglobulin (CD79A) binding protein 1	Mus musculus	4-10
21722213-4	2011	Using global and single-cell targeted gene deletion of subunits contributing to the assembly of GABA(A) Rs mediating tonic (alpha4, delta) or phasic (alpha2) GABAergic transmission, we demonstrate here in the dentate gyrus of adult mice that GABA(A) Rs containing alpha4, but not delta, subunits mediate GABAergic effects on cell proliferation, initial migration and early dendritic development.	gamma-Aminobutyric Acid	96-100	immunoglobulin (CD79A) binding protein 1	Mus musculus	124-130
21722213-4	2011	Using global and single-cell targeted gene deletion of subunits contributing to the assembly of GABA(A) Rs mediating tonic (alpha4, delta) or phasic (alpha2) GABAergic transmission, we demonstrate here in the dentate gyrus of adult mice that GABA(A) Rs containing alpha4, but not delta, subunits mediate GABAergic effects on cell proliferation, initial migration and early dendritic development.	gamma-Aminobutyric Acid	96-100	immunoglobulin (CD79A) binding protein 1	Mus musculus	264-270
21430644-0	2011	The necessity of alpha4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine.	Nicotine	48-56	immunoglobulin (CD79A) binding protein 1	Mus musculus	17-24
21430644-10	2011	These data demonstrate a necessary role for alpha4* nAChRs in the locomotor depressant effect of nicotine but not the reinforcing effects that support ongoing self-administration of nicotine.	Nicotine	97-105	immunoglobulin (CD79A) binding protein 1	Mus musculus	44-51
21406211-0	2011	Dynamic alterations of gene expression of nicotinic acetylcholine receptor alpha7, alpha4 and beta2 subunits in an acute MPTP-lesioned mouse model.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	121-125	immunoglobulin (CD79A) binding protein 1	Mus musculus	83-89
21502501-6	2011	These data suggest that alpha4-dominated enhancement of burst firing in DA neurons, relayed by DA transmission in NAc that is gated by nAChRs containing alpha4 and alpha6 subunits, underlies nicotine self-administration and its long-term maintenance.	Nicotine	191-199	immunoglobulin (CD79A) binding protein 1	Mus musculus	153-170
21406211-6	2011	(1) MPTP treatment transiently increased nAChR alpha7 (after last injection of MPTP 3 and 24 h), alpha4 and beta2 (24 h) mRNA expression in the substantia nigra (SN) and striatum.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	4-8	immunoglobulin (CD79A) binding protein 1	Mus musculus	97-113
19720621-1	2010	Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing alpha4 and beta2 subunits (alpha4beta2*) functionally interact with G-protein-coupled dopamine (DA) D(2) receptors in basal ganglia.	Dopamine	191-199	immunoglobulin (CD79A) binding protein 1	Mus musculus	105-121
21239887-0	2011	Nicotinic acetylcholine receptors containing the alpha4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption.	Nicotine	85-93	immunoglobulin (CD79A) binding protein 1	Mus musculus	49-55
21239887-0	2011	Nicotinic acetylcholine receptors containing the alpha4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption.	Ethanol	131-138	immunoglobulin (CD79A) binding protein 1	Mus musculus	49-55
21239887-3	2011	Although varenicline was designed to be a high affinity partial agonist of nAChRs containing the alpha4 and beta2 subunits (designated as alpha4beta2*), at higher concentrations it can also act upon alpha3beta2*, alpha6*, alpha3beta4* and alpha7 nAChRs.	Varenicline	9-20	immunoglobulin (CD79A) binding protein 1	Mus musculus	97-103
21239887-3	2011	Although varenicline was designed to be a high affinity partial agonist of nAChRs containing the alpha4 and beta2 subunits (designated as alpha4beta2*), at higher concentrations it can also act upon alpha3beta2*, alpha6*, alpha3beta4* and alpha7 nAChRs.	nachrs	75-81	immunoglobulin (CD79A) binding protein 1	Mus musculus	97-103
21239887-5	2011	We found that activation of alpha4* nAChRs was necessary and sufficient for varenicline-induced reduction of alcohol consumption.	Varenicline	76-87	immunoglobulin (CD79A) binding protein 1	Mus musculus	28-34
21239887-6	2011	Consistent with this result, here we show that a more efficacious nAChR agonist, nicotine, also decreased voluntary ethanol intake, and that alpha4* nAChRs are critical for this reduction.	Nicotine	81-89	immunoglobulin (CD79A) binding protein 1	Mus musculus	141-147
21174184-4	2011	PRINCIPAL FINDINGS: Gamma-aminobutyric acid (GABA)(A) receptor subtypes defined by the presence of the alpha1, alpha4, alpha5, beta2, and beta3 subunits and two-pore domain potassium channels (TASK-1, TASK-3, and TREK) have been discovered to mediate, at least in part, the hypnotic, immobilizing or amnestic actions of intravenous and volatile general anesthetics.	gamma-Aminobutyric Acid	20-43	immunoglobulin (CD79A) binding protein 1	Mus musculus	103-143
21174184-4	2011	PRINCIPAL FINDINGS: Gamma-aminobutyric acid (GABA)(A) receptor subtypes defined by the presence of the alpha1, alpha4, alpha5, beta2, and beta3 subunits and two-pore domain potassium channels (TASK-1, TASK-3, and TREK) have been discovered to mediate, at least in part, the hypnotic, immobilizing or amnestic actions of intravenous and volatile general anesthetics.	gamma-Aminobutyric Acid	45-49	immunoglobulin (CD79A) binding protein 1	Mus musculus	103-143
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	monoamine	136-145	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Sodium Chloride	205-211	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Nicotine	213-221	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Tranylcypromine	227-242	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Cocaine	257-264	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Dextroamphetamine	266-279	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
20890227-2	2010	This study aimed to further assess the role of beta2 and coexpressed nAChR subunits in the brain (alpha4, alpha6 and alpha7) to control monoamine-mediated locomotor response, that is, response to novelty, saline, nicotine with tranylcypromine pretreatment, cocaine, d-amphetamine and morphine treatments.	Morphine	284-292	immunoglobulin (CD79A) binding protein 1	Mus musculus	98-123
21347217-0	2011	Voluntary Ethanol Consumption Induced by Social Isolation Reverses the Increase of alpha(4)/delta GABA(A) Receptor Gene Expression and Function in the Hippocampus of C57BL/6J Mice.	Ethanol	10-17	immunoglobulin (CD79A) binding protein 1	Mus musculus	83-114
20736992-0	2010	Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through alpha4/beta2/alpha5 nicotinic acetylcholine receptors.	Nicotine	47-55	immunoglobulin (CD79A) binding protein 1	Mus musculus	108-114
20736992-7	2010	Consistent with a role for (alpha4)(2)(beta2)(2)alpha5 nAChRs in mediating the effect of developmental nicotine exposure on adult passive avoidance behavior, constitutive deletion of the alpha5 nAChR subunit also alters this behavior.	Nicotine	103-111	immunoglobulin (CD79A) binding protein 1	Mus musculus	28-34
20668200-5	2010	Ethanol-activated DAergic neurons expressed higher levels of alpha4, alpha6, and beta3 subunit genes compared with nonactivated neurons.	Ethanol	0-7	immunoglobulin (CD79A) binding protein 1	Mus musculus	61-86
19139153-3	2009	Null mutation of genes encoding the alpha4 or beta2 subunits resulted in complete loss of ACh-stimulated [(3)H]GABA release in all four brain regions.	Acetylcholine	90-93	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
19741505-4	2009	This potentiation was abolished by pretreatment with methyllycaconitine, an antagonist of alpha-7nAChR, or dihydrobetaerythroidine, an antagonist of alpha-4/beta-2nAChR.	Dihydro-beta-Erythroidine	107-130	immunoglobulin (CD79A) binding protein 1	Mus musculus	149-156
19693710-6	2010	These results indicate that alpha-CtxMII-resistant DA release is mediated by alpha4alpha5beta2, (alpha4)(2)(beta2)(3) (HS), and (alpha4)(3)(beta2)(2) (LS) nAChRs.	alpha-ctxmii	28-40	immunoglobulin (CD79A) binding protein 1	Mus musculus	77-83
19693710-6	2010	These results indicate that alpha-CtxMII-resistant DA release is mediated by alpha4alpha5beta2, (alpha4)(2)(beta2)(3) (HS), and (alpha4)(3)(beta2)(2) (LS) nAChRs.	alpha-ctxmii	28-40	immunoglobulin (CD79A) binding protein 1	Mus musculus	97-103
19232663-2	2009	In mLN of mice treated with Poly (I:C), we observed the induction of three sequential waves of type I IFN production, instead of two as is commonly described: early IFNs after 1 h (IFN-beta), late IFNs after 3 h (mostly IFN-alpha1, -alpha2, -alpha 4 and -alpha 5) and "secondary late IFNs" after 6 h (IFN-alpha 6T and -alpha 8/6).	poly	28-32	immunoglobulin (CD79A) binding protein 1	Mus musculus	233-262
19164465-3	2009	Previous studies have shown that cytisine, a partial agonist at alpha4/beta2(*) nAChRs, and a full agonist at alpha3/beta4(*) and alpha7 nAChRs, has antidepressant-like properties in several rodent models of antidepressant efficacy; however, it is not clear whether more selective partial agonists will also be effective in these models.	cytisine	33-41	immunoglobulin (CD79A) binding protein 1	Mus musculus	64-70
19164465-5	2009	3-pyr-Cyt was a partial agonist with very low efficacy at alpha4/beta2(*) nAChRS but had no agonist effects at other nAChRs normally targeted by cytisine, and it was effective in mouse models of antidepressant efficacy.	3-pyr-cyt	0-9	immunoglobulin (CD79A) binding protein 1	Mus musculus	58-64
19139153-3	2009	Null mutation of genes encoding the alpha4 or beta2 subunits resulted in complete loss of ACh-stimulated [(3)H]GABA release in all four brain regions.	gamma-Aminobutyric Acid	111-115	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
17693407-6	2007	Elevated alpha4 expression results in an increase in the GTP-bound state of Rac1, and GTP-bound Rac1 was dramatically reduced in alpha4-deficient cells.	Guanosine Triphosphate	57-60	immunoglobulin (CD79A) binding protein 1	Mus musculus	9-15
18721822-3	2009	Functional GlyRs are formed from a total of five subunits (alpha1-alpha4, beta).	glyrs	11-16	immunoglobulin (CD79A) binding protein 1	Mus musculus	59-72
19020025-0	2008	Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration.	Nicotine	116-124	immunoglobulin (CD79A) binding protein 1	Mus musculus	16-33
18337473-0	2008	Partial deletion of the nicotinic cholinergic receptor alpha 4 or beta 2 subunit genes changes the acetylcholine sensitivity of receptor-mediated 86Rb+ efflux in cortex and thalamus and alters relative expression of alpha 4 and beta 2 subunits.	Acetylcholine	99-112	immunoglobulin (CD79A) binding protein 1	Mus musculus	55-62
18337473-1	2008	Alpha4 and beta2 nicotinic cholinergic receptor (nAChR) subunits can assemble in heterologous expression systems as pentameric receptors with different subunit stoichiometries that exhibit differential sensitivity to activation by acetylcholine, yielding biphasic concentration-effect curves.	Acetylcholine	231-244	immunoglobulin (CD79A) binding protein 1	Mus musculus	0-6
18337473-4	2008	A relatively larger decrease in the component of (86)Rb(+) efflux with lower ACh sensitivity occurred with partial deletion of alpha4 (alpha4(+/-)), whereas a larger decrease in the component with higher ACh sensitivity was elicited by partial deletion of beta2 (beta2(+/-)).	Rubidium	53-55	immunoglobulin (CD79A) binding protein 1	Mus musculus	127-133
18337473-4	2008	A relatively larger decrease in the component of (86)Rb(+) efflux with lower ACh sensitivity occurred with partial deletion of alpha4 (alpha4(+/-)), whereas a larger decrease in the component with higher ACh sensitivity was elicited by partial deletion of beta2 (beta2(+/-)).	Rubidium	53-55	immunoglobulin (CD79A) binding protein 1	Mus musculus	135-141
18337473-4	2008	A relatively larger decrease in the component of (86)Rb(+) efflux with lower ACh sensitivity occurred with partial deletion of alpha4 (alpha4(+/-)), whereas a larger decrease in the component with higher ACh sensitivity was elicited by partial deletion of beta2 (beta2(+/-)).	Acetylcholine	77-80	immunoglobulin (CD79A) binding protein 1	Mus musculus	127-133
18337473-4	2008	A relatively larger decrease in the component of (86)Rb(+) efflux with lower ACh sensitivity occurred with partial deletion of alpha4 (alpha4(+/-)), whereas a larger decrease in the component with higher ACh sensitivity was elicited by partial deletion of beta2 (beta2(+/-)).	Acetylcholine	77-80	immunoglobulin (CD79A) binding protein 1	Mus musculus	135-141
18337473-5	2008	Immunoprecipitation with selective antibodies demonstrated that more than 70% of [(3)H]epibatidine binding sites in both regions contained only alpha4 and beta2 subunits.	epibatidine	87-98	immunoglobulin (CD79A) binding protein 1	Mus musculus	144-150
18321647-2	2008	Sensitivity to acetylcholine (ACh) was increased by the S252F substitution expressed in heterozygosis (alpha4:S252Falpha4:beta2) but was markedly reduced when this mutation was expressed in homozygosis (S252Falpha4:beta2).	Acetylcholine	15-28	immunoglobulin (CD79A) binding protein 1	Mus musculus	103-109
18321647-2	2008	Sensitivity to acetylcholine (ACh) was increased by the S252F substitution expressed in heterozygosis (alpha4:S252Falpha4:beta2) but was markedly reduced when this mutation was expressed in homozygosis (S252Falpha4:beta2).	Acetylcholine	30-33	immunoglobulin (CD79A) binding protein 1	Mus musculus	103-109
17986225-5	2008	KCl- and KA-mediated depolarization down-regulated GABAR alpha1, alpha6 and beta2, but up-regulated alpha4, beta3 and delta subunits in +/+ neurones.	Potassium Chloride	0-3	immunoglobulin (CD79A) binding protein 1	Mus musculus	100-113
17662697-7	2007	In cultures chronically treated with 10nM nicotine, there was significantly increased alpha4* nicotinic-induced Ca(2+) influx elicited by low concentration of ACh (3 microM).	Nicotine	42-50	immunoglobulin (CD79A) binding protein 1	Mus musculus	86-93
17662697-7	2007	In cultures chronically treated with 10nM nicotine, there was significantly increased alpha4* nicotinic-induced Ca(2+) influx elicited by low concentration of ACh (3 microM).	Acetylcholine	159-162	immunoglobulin (CD79A) binding protein 1	Mus musculus	86-93
17693407-6	2007	Elevated alpha4 expression results in an increase in the GTP-bound state of Rac1, and GTP-bound Rac1 was dramatically reduced in alpha4-deficient cells.	Guanosine Triphosphate	86-89	immunoglobulin (CD79A) binding protein 1	Mus musculus	129-135
17631923-0	2007	Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine.	Tritium	119-121	immunoglobulin (CD79A) binding protein 1	Mus musculus	33-39
17631923-0	2007	Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine.	epibatidine	122-133	immunoglobulin (CD79A) binding protein 1	Mus musculus	33-39
17631923-9	2007	Deletion of alpha4 virtually eliminated cytisine-sensitive, higher-affinity [3H]epibatidine binding as did beta2 deletion, confirming that these sites are alpha4beta2*-nAChR.	cytisine	40-48	immunoglobulin (CD79A) binding protein 1	Mus musculus	12-18
17631923-9	2007	Deletion of alpha4 virtually eliminated cytisine-sensitive, higher-affinity [3H]epibatidine binding as did beta2 deletion, confirming that these sites are alpha4beta2*-nAChR.	Tritium	77-79	immunoglobulin (CD79A) binding protein 1	Mus musculus	12-18
17631923-9	2007	Deletion of alpha4 virtually eliminated cytisine-sensitive, higher-affinity [3H]epibatidine binding as did beta2 deletion, confirming that these sites are alpha4beta2*-nAChR.	epibatidine	80-91	immunoglobulin (CD79A) binding protein 1	Mus musculus	12-18
17631923-10	2007	Cytisine-resistant, higher-affinity [3H]epibatidine binding sites are diverse and some of these sites require alpha4 expression.	cytisine	0-8	immunoglobulin (CD79A) binding protein 1	Mus musculus	110-116
17631923-0	2007	Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine.	Acetylcholine	50-63	immunoglobulin (CD79A) binding protein 1	Mus musculus	33-39
17631923-10	2007	Cytisine-resistant, higher-affinity [3H]epibatidine binding sites are diverse and some of these sites require alpha4 expression.	Tritium	37-39	immunoglobulin (CD79A) binding protein 1	Mus musculus	110-116
17631923-10	2007	Cytisine-resistant, higher-affinity [3H]epibatidine binding sites are diverse and some of these sites require alpha4 expression.	epibatidine	40-51	immunoglobulin (CD79A) binding protein 1	Mus musculus	110-116
17341654-5	2007	Gene deletions (alpha4 and beta3) decreased binding of (125)I-alpha-CtxMII without affecting affinity for alpha-CtxMII or inhibition of alpha-CtxMII binding by epibatidine or nicotine.	alpha-ctxmii	62-74	immunoglobulin (CD79A) binding protein 1	Mus musculus	16-32
17631923-14	2007	This provides the first evidence that lower-affinity epibatidine binding sites in the brain require expression of alpha4 subunits.	epibatidine	53-64	immunoglobulin (CD79A) binding protein 1	Mus musculus	114-120
17341654-5	2007	Gene deletions (alpha4 and beta3) decreased binding of (125)I-alpha-CtxMII without affecting affinity for alpha-CtxMII or inhibition of alpha-CtxMII binding by epibatidine or nicotine.	-ctxmii	67-74	immunoglobulin (CD79A) binding protein 1	Mus musculus	16-32
16957604-2	2006	Socially isolated female mice that have received testosterone propionate (1.45 micromol/kg) treatment for 3 weeks during social isolation express aggression, neurosteroid downregulation, and changes in the cortical mRNA expression of several gamma-aminobutyric acid type A receptor subunits (alpha1, alpha2, gamma2 are decreased by 30-40%, and alpha4 and alpha5 are increased by 50%).	Testosterone Propionate	49-72	immunoglobulin (CD79A) binding protein 1	Mus musculus	344-350
15681595-11	2005	These results may explain previous findings that nicotine treatment decreased striatal nAChR-mediated dopamine function, despite an increase in [3H]nicotine (alpha4*) sites.	Nicotine	49-57	immunoglobulin (CD79A) binding protein 1	Mus musculus	158-164
16569710-4	2006	Oocytes injected with alpha4 and beta2 RNA lacking UTR expressed biphasic concentration-response relationships for acetylcholine with high-sensitivity EC50 values of 0.5 to 2.5 microM (14-24% of the population) and low-sensitivity EC50 values of 110 to 180 microM (76-86%).	Acetylcholine	115-128	immunoglobulin (CD79A) binding protein 1	Mus musculus	22-28
16470243-4	2006	In contrast to the embryonic-lethal phenotype of alpha4 integrin-null mice, mice bearing the alpha4(Y991A) mutation were viable and fertile; however, they exhibited defective recruitment of mononuclear leukocytes into thioglycollate-induced peritonitis.	Thioglycolates	218-232	immunoglobulin (CD79A) binding protein 1	Mus musculus	93-99
16339034-12	2005	Our findings show that hypersensitive alpha4* nicotinic receptors in mice mediate changes in the sleep-wake cycle and nicotine-induced seizures resembling ADNFLE.	Nicotine	118-126	immunoglobulin (CD79A) binding protein 1	Mus musculus	38-44
15681595-11	2005	These results may explain previous findings that nicotine treatment decreased striatal nAChR-mediated dopamine function, despite an increase in [3H]nicotine (alpha4*) sites.	Tritium	145-147	immunoglobulin (CD79A) binding protein 1	Mus musculus	158-164
15681595-11	2005	These results may explain previous findings that nicotine treatment decreased striatal nAChR-mediated dopamine function, despite an increase in [3H]nicotine (alpha4*) sites.	Nicotine	148-156	immunoglobulin (CD79A) binding protein 1	Mus musculus	158-164
15551346-4	2005	Administration of NS398 correlated with retention of nAChR alpha4 and to a lesser extent nAChR beta4, but not nAChR alpha5 or alpha7, but nicotine exhibited no similar effect.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	18-23	immunoglobulin (CD79A) binding protein 1	Mus musculus	59-65
15551346-5	2005	Nicotine and NS398 co-administration abolished the NS398-related effect on nAChR alpha4 retention.	Nicotine	0-8	immunoglobulin (CD79A) binding protein 1	Mus musculus	81-87
15551346-5	2005	Nicotine and NS398 co-administration abolished the NS398-related effect on nAChR alpha4 retention.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	13-18	immunoglobulin (CD79A) binding protein 1	Mus musculus	81-87
15551346-5	2005	Nicotine and NS398 co-administration abolished the NS398-related effect on nAChR alpha4 retention.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	51-56	immunoglobulin (CD79A) binding protein 1	Mus musculus	81-87
15252037-12	2004	Our results reveal that the A subunit and alpha-4 (mTap42) require charged residues in separate but overlapping surface regions to associate with the back side of PP2Ac and modulate phosphatase activity.	pp2ac	163-168	immunoglobulin (CD79A) binding protein 1	Mus musculus	51-57
14996991-4	2004	Using transgenic mice with mutations in nAChR subunits, it was demonstrated previously that the alpha4-, alpha5-, and alpha7-subunits are involved in nicotine-induced seizures.	Nicotine	150-158	immunoglobulin (CD79A) binding protein 1	Mus musculus	96-102
14610221-3	2004	Furthermore, some ethanol-related behaviors are associated with a region of mouse chromosome 2 that contains the gene encoding the alpha4 subunit of the nAChR (Chrna4).	Ethanol	18-25	immunoglobulin (CD79A) binding protein 1	Mus musculus	131-137
14691373-10	2003	RESULTS: An association between the alpha4 A529T polymorphism and ethanol"s effects on startle was found in the LSxSS RI strains; those strains that express the A529 variant of alpha4 were more sensitive to ethanol-induced depression of startle.	Ethanol	66-73	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
14691373-10	2003	RESULTS: An association between the alpha4 A529T polymorphism and ethanol"s effects on startle was found in the LSxSS RI strains; those strains that express the A529 variant of alpha4 were more sensitive to ethanol-induced depression of startle.	Ethanol	66-73	immunoglobulin (CD79A) binding protein 1	Mus musculus	177-183
14691373-10	2003	RESULTS: An association between the alpha4 A529T polymorphism and ethanol"s effects on startle was found in the LSxSS RI strains; those strains that express the A529 variant of alpha4 were more sensitive to ethanol-induced depression of startle.	Ethanol	207-214	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
14691373-10	2003	RESULTS: An association between the alpha4 A529T polymorphism and ethanol"s effects on startle was found in the LSxSS RI strains; those strains that express the A529 variant of alpha4 were more sensitive to ethanol-induced depression of startle.	Ethanol	207-214	immunoglobulin (CD79A) binding protein 1	Mus musculus	177-183
14691373-11	2003	The alpha4 gain of function mutants were more sensitive to the effects of both nicotine and ethanol and the beta2 null mutants were less sensitive to both drugs.	Nicotine	79-87	immunoglobulin (CD79A) binding protein 1	Mus musculus	4-10
14691373-11	2003	The alpha4 gain of function mutants were more sensitive to the effects of both nicotine and ethanol and the beta2 null mutants were less sensitive to both drugs.	Ethanol	92-99	immunoglobulin (CD79A) binding protein 1	Mus musculus	4-10
11434511-1	2001	In a recent study, we reported that a restriction fragment length polymorphism associated with the alpha4 nicotinic receptor gene (Chrna4) may play a role in regulating differential sensitivity of LS and SS mouse lines to the seizure-inducing effects of nicotine.	Nicotine	254-262	immunoglobulin (CD79A) binding protein 1	Mus musculus	99-105
12871652-2	2003	This polymorphism leads to an Ala/Thr variation at amino acid position 529 of the alpha4 subunit.	Alanine	30-33	immunoglobulin (CD79A) binding protein 1	Mus musculus	82-88
12871652-2	2003	This polymorphism leads to an Ala/Thr variation at amino acid position 529 of the alpha4 subunit.	Threonine	34-37	immunoglobulin (CD79A) binding protein 1	Mus musculus	82-88
12871652-5	2003	alpha4beta2 receptors containing the T529 variant of the alpha4 subunit exhibited a higher EC(50) value for the high affinity receptor population and an apparent reduced sensitivity to blockade by DHbetaE relative to alpha4beta2 receptors containing the A529 variant of the alpha4 subunit.	Dihydro-beta-Erythroidine	197-204	immunoglobulin (CD79A) binding protein 1	Mus musculus	0-6
12871652-5	2003	alpha4beta2 receptors containing the T529 variant of the alpha4 subunit exhibited a higher EC(50) value for the high affinity receptor population and an apparent reduced sensitivity to blockade by DHbetaE relative to alpha4beta2 receptors containing the A529 variant of the alpha4 subunit.	Dihydro-beta-Erythroidine	197-204	immunoglobulin (CD79A) binding protein 1	Mus musculus	57-63
12766617-0	2003	A polymorphism in the alpha4 nicotinic receptor gene (Chrna4) modulates enhancement of nicotinic receptor function by ethanol.	Ethanol	118-125	immunoglobulin (CD79A) binding protein 1	Mus musculus	22-28
12766617-2	2003	Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein.	Alanine	103-110	immunoglobulin (CD79A) binding protein 1	Mus musculus	52-58
12766617-2	2003	Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein.	Alanine	103-110	immunoglobulin (CD79A) binding protein 1	Mus musculus	200-206
12766617-2	2003	Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein.	Threonine	119-128	immunoglobulin (CD79A) binding protein 1	Mus musculus	52-58
12766617-2	2003	Our laboratory has identified a polymorphism in the alpha4 gene that results in the substitution of an alanine (A) for threonine (T) at amino acid position 529 in the second intracellular loop of the alpha4 protein.	Threonine	119-128	immunoglobulin (CD79A) binding protein 1	Mus musculus	200-206
12739784-4	2002	These data suggest that the SG31 epitope is an activation epitope and that manganese ions activate alpha4 integrins by inducing a conformational change.	Manganese	75-84	immunoglobulin (CD79A) binding protein 1	Mus musculus	99-105
12713636-2	2003	Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit.	Nicotine	120-128	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
12713636-2	2003	Here we investigate the role of the alpha4 nicotinic acetylcholine receptor (nAChR) subunit in mediating the effects of nicotine in the mesolimbic dopamine system in mice lacking the alpha4 subunit.	Dopamine	147-155	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
12713636-5	2003	Non-alpha4 subunit-containing nAChRs are located on dopaminergic neurons, are functional and respond to nicotine as demonstrated by patch clamp recordings.	Nicotine	104-112	immunoglobulin (CD79A) binding protein 1	Mus musculus	4-10
12713636-7	2003	Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice.	Dopamine	92-100	immunoglobulin (CD79A) binding protein 1	Mus musculus	41-47
12713636-7	2003	Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice.	Potassium Chloride	138-141	immunoglobulin (CD79A) binding protein 1	Mus musculus	41-47
12713636-7	2003	Despite the fact that both wild-type and alpha4 null mutant mice show a similar increase in dopamine release in response to intrastriatal KCl perfusion, a nicotine-elicited increase in dopamine levels is not observed in mutant mice.	Nicotine	155-163	immunoglobulin (CD79A) binding protein 1	Mus musculus	41-47
12713636-11	2003	Our results indicate that alpha4-containing nAChRs exert a tonic control on striatal basal dopamine release, which is mediated by a heterogeneous population of nAChRs.	Dopamine	91-99	immunoglobulin (CD79A) binding protein 1	Mus musculus	26-32
12393730-5	2003	Furthermore, Tyr AG490 inhibited rapid CCL21-mediated up-regulation of alpha4 and beta2 integrin adhesiveness in static adhesion assays and under physiological flow, whereas adhesion induced by phorbol myristate acetate remained unaltered.	Tyrphostins	13-16	immunoglobulin (CD79A) binding protein 1	Mus musculus	71-77
12473243-0	2002	alpha4 integrins and L-selectin differently orchestrate T-cell activity during diabetes prevention following oral administration of CTB-insulin.	ctb-insulin	132-143	immunoglobulin (CD79A) binding protein 1	Mus musculus	0-6
12473243-10	2002	Taken together, our results suggest that L-selectin and alpha4-integrin have distinct but complementary roles in the generation and function of regulatory CD4+ T cells following CTB-insulin administration.	bromebric acid	178-181	immunoglobulin (CD79A) binding protein 1	Mus musculus	56-62
12130686-1	2002	Nicotine-stimulated (86)Rb(+) efflux and [(3)H]cytisine binding, both of which seem to measure the nicotinic acetylcholine receptor, composed of alpha4 and beta2 subunits, were assessed in eight brain regions obtained from 14 inbred mouse strains.	Nicotine	0-8	immunoglobulin (CD79A) binding protein 1	Mus musculus	145-151
12021063-0	2002	Steroids modulate the expression of alpha4 integrin in mouse blastocysts and uterus during implantation.	Steroids	0-8	immunoglobulin (CD79A) binding protein 1	Mus musculus	36-42
12021063-8	2002	Immunolocalization of protein expression of alpha4 and beta1 integrin subunits indicate that steroids modulate the expression of alpha4beta1 integrin receptor in the mouse blastocyst as well as the uterus and that a differential expression is observed with exposure to progesterone and estrogen.	Steroids	93-101	immunoglobulin (CD79A) binding protein 1	Mus musculus	44-50
11927835-6	2002	Those RI strains carrying the LS-like alpha4 RFLP were significantly more sensitive to the effects of nicotine on Y-maze crosses and rears, temperature and respiration and were less sensitive to the effects of nicotine on acoustic startle than those strains carrying the SS-like alpha4 RFLP.	Nicotine	102-110	immunoglobulin (CD79A) binding protein 1	Mus musculus	38-44
11927835-6	2002	Those RI strains carrying the LS-like alpha4 RFLP were significantly more sensitive to the effects of nicotine on Y-maze crosses and rears, temperature and respiration and were less sensitive to the effects of nicotine on acoustic startle than those strains carrying the SS-like alpha4 RFLP.	Nicotine	210-218	immunoglobulin (CD79A) binding protein 1	Mus musculus	38-44
11927835-8	2002	These results suggest that genetically determined differences in sensitivity to nicotine may be explained, in part, by variability associated with at least two of the neuronal nicotinic receptor genes, alpha4 and alpha6.	Nicotine	80-88	immunoglobulin (CD79A) binding protein 1	Mus musculus	202-219
11434511-3	2001	A polymorphism in the coding portion of the alpha4 gene was found (1587A to G) which should result in a threonine/alanine substitution at position 529 (T529A).	Threonine	104-113	immunoglobulin (CD79A) binding protein 1	Mus musculus	44-50
11434511-3	2001	A polymorphism in the coding portion of the alpha4 gene was found (1587A to G) which should result in a threonine/alanine substitution at position 529 (T529A).	Alanine	114-121	immunoglobulin (CD79A) binding protein 1	Mus musculus	44-50
11238661-5	2001	Direct cross-linking of the alpha(4) integrin subunit by surface-bound mAbs also elicited superoxide release and release of the secondary granule marker, lactoferrin.	Superoxides	90-100	immunoglobulin (CD79A) binding protein 1	Mus musculus	28-36
10942032-9	2000	In a study that used RI strains derived from two selectively bred mouse lines (LS and SS), an association between sensitivity to nicotine-induced seizures and an RFLP associated with the alpha4 gene was found.	Nicotine	129-137	immunoglobulin (CD79A) binding protein 1	Mus musculus	187-193
11146122-5	2000	The expression of alpha(2), alpha(4), beta(3) and gamma(1) mRNAs in olivary neurons was affected differentially by harmaline administration.	Harmaline	115-124	immunoglobulin (CD79A) binding protein 1	Mus musculus	28-58
10942032-10	2000	These data support the assertion that both alpha4 and alpha7 receptor types are involved in modulating convulsions produced by nicotine.	Nicotine	127-135	immunoglobulin (CD79A) binding protein 1	Mus musculus	43-49
10803206-6	1999	The alpha 4 nAChR is associated mainly with the beta 2 subunit, and may form a component of the nicotinic pain pathways modulating the antinociceptive effect of nicotine.	Nicotine	161-169	immunoglobulin (CD79A) binding protein 1	Mus musculus	4-11