PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
21056113-5	2011	The activity of chicken cholesterol 7alpha hydroxylase (CYP7A1), a key enzyme in bile acid synthesis, mRNA expression, and bile acid excretion, was stimulated by supplementation of the culture medium with a low concentration (0.01 muM) of T0901317.	Bile Acids and Salts	81-90	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	24-54
21056113-5	2011	The activity of chicken cholesterol 7alpha hydroxylase (CYP7A1), a key enzyme in bile acid synthesis, mRNA expression, and bile acid excretion, was stimulated by supplementation of the culture medium with a low concentration (0.01 muM) of T0901317.	Bile Acids and Salts	81-90	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	56-62
21056113-5	2011	The activity of chicken cholesterol 7alpha hydroxylase (CYP7A1), a key enzyme in bile acid synthesis, mRNA expression, and bile acid excretion, was stimulated by supplementation of the culture medium with a low concentration (0.01 muM) of T0901317.	Bile Acids and Salts	123-132	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	24-54
21056113-5	2011	The activity of chicken cholesterol 7alpha hydroxylase (CYP7A1), a key enzyme in bile acid synthesis, mRNA expression, and bile acid excretion, was stimulated by supplementation of the culture medium with a low concentration (0.01 muM) of T0901317.	Bile Acids and Salts	123-132	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	56-62
15629111-0	2005	Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.	Bile Acids and Salts	96-106	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	32-62
18499494-6	2008	The present results showed that the mRNA expression of CYP7A1 and synthesis of bile acids was low in embryonic stages, suggesting that FXR might be a key regulator of CYP7A1 gene expression in the chicken embryo.	Bile Acids and Salts	79-89	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	167-173
15629111-4	2005	Whereas bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, mRNA expression of these nuclear receptors is unchanged by xenobiotics.	Bile Acids and Salts	8-18	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	28-34
15629111-0	2005	Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.	Bile Acids and Salts	96-106	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	64-70
15629111-1	2005	The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated in order to control intrahepatic cholesterol and bile acid levels.	Bile Acids and Salts	128-137	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	18-48
15629111-1	2005	The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated in order to control intrahepatic cholesterol and bile acid levels.	Bile Acids and Salts	128-137	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	50-56
14654239-1	2003	3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) and cholesterol 7 alpha-hydroxylase (CYP7A1), essential enzymes of cholesterol synthesis and excretion, respectively, were isolated from a chicken liver cDNA library.	Cholesterol	59-70	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	92-98
14654239-6	2003	Changes in chicken HMGR and CYP7A1 mRNA expression with nutritional state were examined and were shown to respond to certain nutritional treatments, i.e. fast refeeding and cholesterol supplementation.	Cholesterol	173-184	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	28-34
14654239-9	2003	The present study is the first to report the molecular characterization of HMGR and CYP7A1, key enzymes of cholesterol metabolism in avian species.	Cholesterol	107-118	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	84-90
11368995-5	2001	Cholesterol 7alpha-hydroxylase activity was increased by lovastatin (11%) and by lovastatin plus TRF(25) (19%).	Lovastatin	57-67	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	0-30
11368995-5	2001	Cholesterol 7alpha-hydroxylase activity was increased by lovastatin (11%) and by lovastatin plus TRF(25) (19%).	Lovastatin	81-91	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	0-30
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	ase	193-196	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	0-31
32616273-0	2020	Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.	Betaine	9-16	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	136-142
32475448-0	2020	Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.	Betaine	9-16	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	136-142
32475448-5	2020	Accordingly, the cholesterol biosynthetic enzymes, sterol regulator element-binding protein 2 (SREBP2) and 3-hydroxy-3-methylglutaryl coenzyme A reductase, were decreased, while cholesterol-7alpha-hydroxylase (CYP7A1), which converts cholesterol to bile acids, was increased at both mRNA and protein levels in betaine-treated offspring chickens.	Cholesterol	17-28	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	210-216
30790719-4	2019	The liver mRNA levels of fatty acid transport protein (FATP-1), farnesoid X receptor (FXR), AMPK alpha 1 subunit (AMPKalpha1), and glucocorticoid receptor were significantly upregulated in DEX-treated broilers; the gene expression of liver cholesterol 7 alpha-hydroxylase (CYP7A1) was significantly downregulated.	Dextromethorphan	189-192	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	240-271
30790719-4	2019	The liver mRNA levels of fatty acid transport protein (FATP-1), farnesoid X receptor (FXR), AMPK alpha 1 subunit (AMPKalpha1), and glucocorticoid receptor were significantly upregulated in DEX-treated broilers; the gene expression of liver cholesterol 7 alpha-hydroxylase (CYP7A1) was significantly downregulated.	Dextromethorphan	189-192	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	273-279
30790719-5	2019	The protein level of liver CYP7A1 was significantly decreased by DEX treatment at both 24 and 72 h, while the protein level of p-AMPK/ t-AMPK stayed unchanged.	Dextromethorphan	65-68	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	27-33
30790719-6	2019	In the in vitro cultured hepatocytes, compound C pretreatment blocked the increase in CYP7A1 protein level by DEX and significantly suppressed FATP-1, SREBP-1c, FXR, and CYP7A1 gene expression stimulated by DEX.	Dextromethorphan	110-113	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	86-92
25860502-5	2015	Accordingly, the cholesterol biosynthetic enzyme HMGCR was up-regulated (P < 0.05 for both mRNA and protein), while CYP7A1 which converts cholesterol to bile acids was down-regulated (P < 0.05 for mRNA and P = 0.07 for protein).	Cholesterol	141-152	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	119-125
25860502-5	2015	Accordingly, the cholesterol biosynthetic enzyme HMGCR was up-regulated (P < 0.05 for both mRNA and protein), while CYP7A1 which converts cholesterol to bile acids was down-regulated (P < 0.05 for mRNA and P = 0.07 for protein).	Bile Acids and Salts	156-166	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	119-125
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	Bile Acids and Salts	100-109	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	0-31
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	Bile Acids and Salts	100-109	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	33-39
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	Cholesterol	114-125	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	0-31
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	Cholesterol	114-125	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	33-39
6838700-1	1983	AMO 1618 (2-isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride) was added to corn-soy based diets and fed to 9-week-old female chickens for 3 weeks to measure the inhibition of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A (HMG-CoA) reductase and cholesterol 7 alpha-hydroxylase.	AMO-1618	0-8	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	284-315
30951597-8	2019	In conclusion, dietary CLA supplementation decreased the accumulation of lipids including abdominal fat and cholesterol in the liver and egg of laying hens, probably by upregulating hepatic LDLR expression and downregulating hepatic HMGR and CYP7A1 expression.	Linoleic Acids, Conjugated	23-26	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	242-248
24886784-9	2014	Cholesterol 7 alpha-hydroxylase (Cyp7a1) and apolipoprotein H (Apoh), which act in the synthesis of bile acid and cholesterol efflux, showed more expression in the livers of hens given dietary ASE supplementation.	ase	193-196	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	33-39
23031517-12	2012	These results in female broilers suggest that Eq decreased blood TG by upregulating CPTI and downregulating FAS mRNA expression in the liver, and that high serum cholesterol levels stimulated CYP7A1 gene transcription in the liver.	Cholesterol	162-173	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	192-198
23458092-1	2013	The COUP-TFII (chicken ovalbumin upstream promoter-transcription factor II) nuclear receptor, which is composed of a DNA-binding domain and a ligand-binding domain, exerts pleiotropic effects on development and cell differentiation by regulating the transcription of its target genes, including Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1), which plays important roles in catabolism of cholesterol in the liver.	Cholesterol	404-415	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	295-301
23458092-1	2013	The COUP-TFII (chicken ovalbumin upstream promoter-transcription factor II) nuclear receptor, which is composed of a DNA-binding domain and a ligand-binding domain, exerts pleiotropic effects on development and cell differentiation by regulating the transcription of its target genes, including Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1), which plays important roles in catabolism of cholesterol in the liver.	Cholesterol	404-415	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	303-356
23499949-6	2013	The mRNA levels of cholesterol metabolism-related genes such as 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase were significantly decreased after 4 h of fasting.	Cholesterol	19-30	cytochrome P450 family 7 subfamily A member 1	Gallus gallus	109-139