PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35612672-0	2022	Uroplakin II as a single marker for luminal versus basal molecular subtypes in muscle invasive urothelial carcinoma.	Phenobarbital	36-43	uroplakin 2	Homo sapiens	0-12
35612672-4	2022	The 1% cutoff of the UPII stain predicts the luminal subtype with the sensitivity and specificity of 95% and 56%, respectively.	Phenobarbital	45-52	uroplakin 2	Homo sapiens	21-25
35612672-8	2022	The current study shows that evaluating the staining proportion score of UPII can accurately predict basal and luminal subtypes of muscle-invasive bladder cancer.	Phenobarbital	111-118	uroplakin 2	Homo sapiens	73-77
6308275-12	1983	The increase in uranaffin-positive granules using UP II did not result in an increase in non-specificity of the staining reaction.	uranaffin	16-25	uroplakin 2	Homo sapiens	50-55
35262646-1	2022	Importance: Primary results from the Measure Up 1 and Measure Up 2 studies demonstrated upadacitinib efficacy and safety through 16 weeks in patients with atopic dermatitis.	upadacitinib	88-100	uroplakin 2	Homo sapiens	62-66
1096820-1	1975	By modification of the enrichment culture procedure three bacterial strains capable of degrading crude oil in sea water were isolated in pure culture, UP-2, UP-3, and UP-4.	Oils	103-106	uroplakin 2	Homo sapiens	151-161
16345671-0	1980	Incorporation of P and Growth of Pseudomonad UP-2 on n-Tetracosane.	tetracosane	53-66	uroplakin 2	Homo sapiens	45-49
16345671-1	1980	Cultures of the marine pseudomonad UP-2 growing on n-tetracosane contained both free cells and cells bound to the solid hydrocarbon.	tetracosane	51-64	uroplakin 2	Homo sapiens	35-39
16345671-1	1980	Cultures of the marine pseudomonad UP-2 growing on n-tetracosane contained both free cells and cells bound to the solid hydrocarbon.	Hydrocarbons	120-131	uroplakin 2	Homo sapiens	35-39
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	65-68	uroplakin 2	Homo sapiens	7-11
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	120-123	uroplakin 2	Homo sapiens	7-11
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	120-123	uroplakin 2	Homo sapiens	7-11
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	120-123	uroplakin 2	Homo sapiens	7-11
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	120-123	uroplakin 2	Homo sapiens	7-11
1096820-2	1975	Strain UP-2 appears to be highly specialized for growth on crude oil in sea water since it showed strong preference for oil or oil degradation products as substrates for growth, converted 66% of the oil into a form no longer extractable by organic solvents, quantitatively degraded the paraffinic fraction (gas chromatographic analysis), emulsified the oil during exponential growth, and produced 1.6 x 10-8 cells per mg of oil.	Oils	120-123	uroplakin 2	Homo sapiens	7-11
1096820-3	1975	After exhaustive growth of UP-2 on crude oil the residual oil supported the growth of UP-3 and UP-4, but not a previously isolated oil-degrading bacterium, RAG-1.	Oils	41-44	uroplakin 2	Homo sapiens	27-31
1096820-3	1975	After exhaustive growth of UP-2 on crude oil the residual oil supported the growth of UP-3 and UP-4, but not a previously isolated oil-degrading bacterium, RAG-1.	Oils	58-61	uroplakin 2	Homo sapiens	27-31
1096820-3	1975	After exhaustive growth of UP-2 on crude oil the residual oil supported the growth of UP-3 and UP-4, but not a previously isolated oil-degrading bacterium, RAG-1.	Oils	58-61	uroplakin 2	Homo sapiens	27-31
1096820-5	1975	The growth of UP-3 and UP-4 on UP-2 and RAG-1-degraded oil resulted in the production of new paraffinic compounds as revealed by gas chromatography.	paraffinic compounds	93-113	uroplakin 2	Homo sapiens	31-35
25085582-10	2014	Our results indicate that the combination of Ad/PSCAE/UPII/E1A with cisplatin exerts a synergistic antitumor effect on human bladder cancer cells and is a potential combined treatment strategy for bladder cancer.	Cisplatin	68-77	uroplakin 2	Homo sapiens	54-58
32339497-6	2020	Mouse MIBC that developed at 24 weeks of BBN treatment showed morphologic and genetic similarities to the basal squamous subtypes of human MIBC, irrespective of pre-induction of Trp53 mutation or whether the cell of origin was Krt5- or Upk2-expressing cells.	4-METHYL-2-PENTANOL	6-10	uroplakin 2	Homo sapiens	236-240
30627578-13	2018	Positive correlations were observed between concentration of UP2 in plasma and TAC concentration in urine and between UP2 concentration in plasma and GSH concentration in the same material.	Glutathione	150-153	uroplakin 2	Homo sapiens	118-121
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	Mitomycin	111-120	uroplakin 2	Homo sapiens	92-96
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	Mitomycin	122-125	uroplakin 2	Homo sapiens	92-96
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	131-150	uroplakin 2	Homo sapiens	92-96
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	152-156	uroplakin 2	Homo sapiens	92-96
28781650-4	2017	The results of the MTT assay revealed that combination therapy, using Ad5-UPII-E1A and MMC or HCPT, synergistically inhibited the viability of bladder cancer cells in a dose- and time-dependent manner when compared with either agent alone.	monooxyethylene trimethylolpropane tristearate	19-22	uroplakin 2	Homo sapiens	74-78
28781650-6	2017	Treatment with MMC or HCPT enhanced Ad5-UPII-E1A-induced apoptosis in 5,637 cells, observed by transmission electron microscopy.	Mitomycin	15-18	uroplakin 2	Homo sapiens	40-44
28781650-6	2017	Treatment with MMC or HCPT enhanced Ad5-UPII-E1A-induced apoptosis in 5,637 cells, observed by transmission electron microscopy.	hydroxycamptothecinum	22-26	uroplakin 2	Homo sapiens	40-44
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Arginine	33-36	uroplakin 2	Homo sapiens	78-82
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Arginine	33-36	uroplakin 2	Homo sapiens	155-159
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Glycine	37-40	uroplakin 2	Homo sapiens	78-82
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Glycine	37-40	uroplakin 2	Homo sapiens	155-159
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Aspartic Acid	41-44	uroplakin 2	Homo sapiens	78-82
27687590-3	2016	In this study, we constructed an Arg-Gly-Asp (RGD)-modified adenovirus, RGDAd-UPII-TK, that carries a suicide gene called HSV-TK that is driven by a human UPII promoter.	Aspartic Acid	41-44	uroplakin 2	Homo sapiens	155-159
34025787-6	2021	Furthermore, survival analysis was performed on the most notable biomarker, uroplakin 2 (UPK2), which was downloaded from the Oncomine database, and its effect on prognosis was assessed.	oncomine	126-134	uroplakin 2	Homo sapiens	76-87
34025787-6	2021	Furthermore, survival analysis was performed on the most notable biomarker, uroplakin 2 (UPK2), which was downloaded from the Oncomine database, and its effect on prognosis was assessed.	oncomine	126-134	uroplakin 2	Homo sapiens	89-93
33218277-5	2020	The ability of rAAV9-UPII-TK-EGFP to penetrate the glycosaminoglycan (GAG) layer on the surface of bladder cells and to transduce the bladder cells in vivo was very high.	Glycosaminoglycans	51-68	uroplakin 2	Homo sapiens	21-25
33218277-5	2020	The ability of rAAV9-UPII-TK-EGFP to penetrate the glycosaminoglycan (GAG) layer on the surface of bladder cells and to transduce the bladder cells in vivo was very high.	Glycosaminoglycans	70-73	uroplakin 2	Homo sapiens	21-25
28781650-7	2017	Western blot analysis revealed that MMC and HCPT enhanced the E1A expression of the Ad5-UPII-E1A vectorin a dose-dependent manner.	Mitomycin	36-39	uroplakin 2	Homo sapiens	88-92
28781650-7	2017	Western blot analysis revealed that MMC and HCPT enhanced the E1A expression of the Ad5-UPII-E1A vectorin a dose-dependent manner.	hydroxycamptothecinum	44-48	uroplakin 2	Homo sapiens	88-92
28781650-8	2017	The present study demonstrated that Ad5-UPII-E1A combined with MMC or HCPT resulted in synergistic cytotoxicity in a process which involved the promotion of apoptosis in bladder cancer cell lines.	Mitomycin	63-66	uroplakin 2	Homo sapiens	40-44
28781650-8	2017	The present study demonstrated that Ad5-UPII-E1A combined with MMC or HCPT resulted in synergistic cytotoxicity in a process which involved the promotion of apoptosis in bladder cancer cell lines.	hydroxycamptothecinum	70-74	uroplakin 2	Homo sapiens	40-44
28781650-9	2017	MMC and HCPT also promoted the oncolytic effect of Ad5-UPII-E1A.	Mitomycin	0-3	uroplakin 2	Homo sapiens	55-59
28781650-9	2017	MMC and HCPT also promoted the oncolytic effect of Ad5-UPII-E1A.	hydroxycamptothecinum	8-12	uroplakin 2	Homo sapiens	55-59
28743151-0	2017	[Remifentanil Up2date - Part 1].	Remifentanil	1-13	uroplakin 2	Homo sapiens	14-17
19322012-10	2009	The E1A protein was markedly positive in the samples of BIU-87 cells infected with recombinant adenovirus Ad-UPII-E1A.	biu	56-59	uroplakin 2	Homo sapiens	109-113
24978921-6	2014	DESIGN: Uroplakin II and III antibodies were optimized for staining using a horseradish peroxidase-polymer detection system and were visualized with 3,3"-diaminobenzidine.	3,3'-Diaminobenzidine	149-170	uroplakin 2	Homo sapiens	8-20
24656362-1	2014	Two novel macrocyclic 6-methyluracilic amphiphiles (uracilophanes) with four (UP1) and two (UP2) uracil moieties and ammonium groups have been synthesized.	6-methyluracilic amphiphiles	22-50	uroplakin 2	Homo sapiens	92-95
24656362-1	2014	Two novel macrocyclic 6-methyluracilic amphiphiles (uracilophanes) with four (UP1) and two (UP2) uracil moieties and ammonium groups have been synthesized.	uracilophanes	52-65	uroplakin 2	Homo sapiens	92-95
24656362-1	2014	Two novel macrocyclic 6-methyluracilic amphiphiles (uracilophanes) with four (UP1) and two (UP2) uracil moieties and ammonium groups have been synthesized.	Uracil	30-36	uroplakin 2	Homo sapiens	92-95
24656362-8	2014	Unexpectedly, the cryptand-like uracilophane UP2 with the same hydrophobicity as UP3 does not form aggregates.	uracilophane	32-44	uroplakin 2	Homo sapiens	45-48
25039174-3	2014	The results showed that the modified extract, prepared by Rhodiolae Crenulatae Radix et Rhizoma extract grinding 5 min with the same amount of lactose UP2, which hygroscopic initial velocity, acceleration, and critical relative humidity moisture were less than that of Rhodiolae Crenulatae Radix et Rhizoma extract and the mixture dramatically.	Lactose	143-150	uroplakin 2	Homo sapiens	151-154
19513619-2	2009	The 20 mer random oligonucleotide library was synthesized, hybridized with in vitro transcripted total UP II cRNA, then digested by RNase H. After primer extension and autoradiography, the AAS of UP II were selected.	Oligonucleotides	18-33	uroplakin 2	Homo sapiens	196-201
19513619-9	2009	The AAS of UP II mRNA was effectively selected in vitro by random oligonucletide library/RNase H cleavage method in combination with computer software analysis, which had important reference values for further studying biological functions of UP II gene and targeted therapeutic strategy for TCC of bladder.	oligonucletide	66-80	uroplakin 2	Homo sapiens	11-16
19322012-11	2009	MTT assay demonstrated recombinant adenovirus Ad-UPII-E1A inhibited bladder cancer cell BIU-87 growth.	monooxyethylene trimethylolpropane tristearate	0-3	uroplakin 2	Homo sapiens	49-53
19322012-11	2009	MTT assay demonstrated recombinant adenovirus Ad-UPII-E1A inhibited bladder cancer cell BIU-87 growth.	biu	88-91	uroplakin 2	Homo sapiens	49-53
16567801-8	2006	The drastically different carbohydrate processing of the UPIa and UPIb proteins, two closely related members of the tetraspanin family, may reflect differences in their folding and masking due to their interactions with their associated proteins, UPII and UPIIIa, respectively.	Carbohydrates	26-38	uroplakin 2	Homo sapiens	247-251
16116969-6	2005	Under the induction of Lipofectamine 2000, the recombinant was transfected into Uroplakin II negative bladder cancer cell line EJ.	Lipofectamine	23-41	uroplakin 2	Homo sapiens	80-92
8530366-8	1995	The formation of UPII homodimers is sensitive, however, to octyl glucoside that can solubilize the AUMs.	octyl-beta-D-glucoside	59-74	uroplakin 2	Homo sapiens	17-21
12097284-0	2002	Identification of human uroplakin II promoter and its use in the construction of CG8840, a urothelium-specific adenovirus variant that eliminates established bladder tumors in combination with docetaxel.	Docetaxel	193-202	uroplakin 2	Homo sapiens	24-36
15054105-3	2004	Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb and, to a lesser extent, UPIa.	Troglitazone	43-55	uroplakin 2	Homo sapiens	119-123
15054105-3	2004	Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb and, to a lesser extent, UPIa.	Troglitazone	57-59	uroplakin 2	Homo sapiens	119-123
15054105-3	2004	Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb and, to a lesser extent, UPIa.	Rosiglitazone	65-78	uroplakin 2	Homo sapiens	119-123