PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35453378-5	2022	Under drought stress, wheat seedlings responded in proline accumulation that was correlated with the P5CS gene expression.	Proline	51-58	aldehyde dehydrogenase 18 family member A1	Homo sapiens	101-105
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Proline	213-220	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Ornithine	222-231	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Citrulline	233-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Citrulline	233-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Citrulline	233-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-106
32798076-1	2021	BACKGROUND: The ALDH18A1 gene is located at 10q24.1 and encodes delta-1-pyrroline-5-carboxylate synthetase (P5CS), a mitochondrial bifunctional enzyme that catalyzes the first two steps in de novo biosynthesis of proline, ornithine, citrulline, and arginine.	Arginine	249-257	aldehyde dehydrogenase 18 family member A1	Homo sapiens	108-112
32798076-4	2021	CASE REPORT: Here, we report a girl with compound heterozygous disease-causing variants (c.-28-2A>G and c.383G>A, p.Arg128His) in the ALDH18A1 gene, revealed by whole exome sequencing.	arg128his	116-125	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-142
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	30-72
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	74-82
34390414-5	2021	Proline can be synthesized by aldehyde dehydrogenase family 18 member A1 (ALDH18A1) and delta1-pyrroline-5-carboxylate reductase (PYCR), up-regulating ALDH18A1 and PYCR can promote the proliferation and invasion of cancer cells.	Proline	0-7	aldehyde dehydrogenase 18 family member A1	Homo sapiens	151-159
34769188-6	2021	P5C is produced by P5C synthase (P5CS) from glutamate, and ornithine via ornithine delta-amino acid transferase (deltaOAT).	Glutamic Acid	44-53	aldehyde dehydrogenase 18 family member A1	Homo sapiens	19-31
34769188-6	2021	P5C is produced by P5C synthase (P5CS) from glutamate, and ornithine via ornithine delta-amino acid transferase (deltaOAT).	Glutamic Acid	44-53	aldehyde dehydrogenase 18 family member A1	Homo sapiens	33-37
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Proline	100-107	aldehyde dehydrogenase 18 family member A1	Homo sapiens	24-63
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Proline	100-107	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-69
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Ornithine	112-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	24-63
35286254-1	2022	The bifunctional enzyme Delta1-pyrroline-5-carboxylate synthase (P5CS) is vital to the synthesis of proline and ornithine, playing an essential role in human health and agriculture.	Ornithine	112-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-69
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	aldehyde dehydrogenase 18 family member A1	Homo sapiens	102-144
6115302-2	1981	Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid.	Ornithine	63-72	aldehyde dehydrogenase 18 family member A1	Homo sapiens	76-116
6115302-2	1981	Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid.	Proline	162-169	aldehyde dehydrogenase 18 family member A1	Homo sapiens	76-116
6115302-2	1981	Using a radioisotopic assay, we have studied the regulation by ornithine of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the first step of proline biosynthesis from glutamic acid.	Glutamic Acid	188-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	76-116
6144541-1	1984	A radioisotopic assay is described for measuring the activity of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the formation of delta 1-pyrroline-5-carboxylic acid from glutamic acid.	delta-1-pyrroline-5-carboxylate	150-185	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-105
6144541-1	1984	A radioisotopic assay is described for measuring the activity of delta 1-pyrroline-5-carboxylate synthase, the enzyme that catalyzes the formation of delta 1-pyrroline-5-carboxylic acid from glutamic acid.	Glutamic Acid	191-204	aldehyde dehydrogenase 18 family member A1	Homo sapiens	65-105
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	26-33	aldehyde dehydrogenase 18 family member A1	Homo sapiens	146-154
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	102-144
33646427-8	2021	Two of the enzymes in the proline biosynthetic pathway, pyrroline-5-carboxylate reductase (PYCR1) and Aldehyde Dehydrogenase 18 Family Member A1 (ALDH18A1), are upregulated in liver cancer of both human and animal models, while proline catabolic enzymes, such as proline dehydrogenase (PRODH) are downregulated.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	146-154
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	12-20
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	39-81
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	83-87
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	150-155
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	157-162
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	197-202
33573605-1	2021	BACKGROUND: ALDH18A1 mutations lead to delta-1-pyrroline-5-carboxylate-synthetase (P5CS) deficiency, which is a urea cycle-related disorder including SPG9A, SPG9B, autosomal dominant cutis laxa-3 (ADCL3), and autosomal recessive cutis laxa type 3A (ARCL3A).	Urea	112-116	aldehyde dehydrogenase 18 family member A1	Homo sapiens	249-255
33573605-11	2021	Analysis of serum amino acid levels revealed that two SPG9A patients and two unaffected family members had low citrulline levels and one had a low level of ornithine.	Citrulline	111-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	54-59
33573605-11	2021	Analysis of serum amino acid levels revealed that two SPG9A patients and two unaffected family members had low citrulline levels and one had a low level of ornithine.	Ornithine	156-165	aldehyde dehydrogenase 18 family member A1	Homo sapiens	54-59
32516727-10	2020	Also, increased total soluble carbohydrates, cysteine, and Pro accumulation with increased Pro synthesizing enzyme (Delta1-pyrroline-5-carboxylate synthetase (P5CS) and decreased Pro degrading enzyme (proline dehydrogenase) in Mel + Ca2+ treated plants conferred As toxicity tolerance.	Proline	59-62	aldehyde dehydrogenase 18 family member A1	Homo sapiens	122-157
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	delta-1-pyrroline-5-carboxylate	67-90	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	delta-1-pyrroline-5-carboxylate	67-90	aldehyde dehydrogenase 18 family member A1	Homo sapiens	34-38
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	delta-1-pyrroline-5-carboxylate	34-37	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Proline	135-142	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Proline	135-142	aldehyde dehydrogenase 18 family member A1	Homo sapiens	34-38
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Ornithine	147-156	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-32
32770108-1	2021	Pyrroline-5-carboxylate synthase (P5CS) catalyzes the synthesis of pyrroline-5-carboxylate (P5C), a key precursor for the synthesis of proline and ornithine.	Ornithine	147-156	aldehyde dehydrogenase 18 family member A1	Homo sapiens	34-38
32770108-9	2021	The loss of P5CS in cells leads to abnormal purine metabolism and lipid-droplet accumulation.	purine	44-50	aldehyde dehydrogenase 18 family member A1	Homo sapiens	12-16
32770108-10	2021	The reduced lipid-droplet consumption is likely due to decreased expression of the fatty acid transporter, CPT1, and few beta-oxidation-related genes following P5CS knockdown.	Fatty Acids	83-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	160-164
32770108-11	2021	Surprisingly, we found that P5CS is required for mitochondrial respiratory complex organization and that the respiration defects in P5CS knockout cells likely contribute to the metabolic defects in purine synthesis and lipid consumption.	purine	198-204	aldehyde dehydrogenase 18 family member A1	Homo sapiens	132-136
33465163-9	2021	MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production.	Proline	80-87	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-53
33465163-9	2021	MYCN-cluster cases showed high expression of ALDH18A1, encoding P5CS related to proline production.	Proline	80-87	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-68
32960509-4	2020	Supervised analysis identified two proteins of proline biosynthesis pathway, PYCR1 and ALDH18A1, that were significantly associated with resistance to treatment based on pattern dominance.	Proline	47-54	aldehyde dehydrogenase 18 family member A1	Homo sapiens	87-95
31726117-9	2020	Besides PYCR1, we found that additional proline biosynthetic enzymes, such as ALDH18A1, were upregulated in HCC models and also regulated HCC cell proliferation.	isoleucyl-prolyl-proline	40-47	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-86
32579878-11	2020	The application of PEN and Ca induced significantly P5CS and SOD expression in RGS003 under drought stress after 24 h. Overall, these data demonstrated that PEN and Ca have the ability to enhance the tolerance against the drought stress in canola plants.	penconazole	19-22	aldehyde dehydrogenase 18 family member A1	Homo sapiens	52-56
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	20-27	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	150-157	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
32637352-2	2020	P5CS is involved in proline biosynthesis and targeting ALDH18A1 has previously been shown to inhibit melanoma development by decreasing intracellular proline levels to increase the phosphorylation of eIF2alpha mediated by GCN2, which then impairs mRNA translation.	Proline	150-157	aldehyde dehydrogenase 18 family member A1	Homo sapiens	55-63
32017139-0	2020	Delta1 -Pyrroline-5-carboxylate synthetase (P5CS) deficiency: An emergent multifaceted urea cycle-related disorder.	Urea	87-91	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
32017139-0	2020	Delta1 -Pyrroline-5-carboxylate synthetase (P5CS) deficiency: An emergent multifaceted urea cycle-related disorder.	Urea	87-91	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
30853934-5	2019	P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle.	Glutamic Acid	47-56	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
30973753-5	2019	Instead, we discovered that the glutamate-consuming enzymes phosphoserine aminotransferase 1 (PSAT1) and aldehyde dehydrogenase 18A1 (ALDH18A1)/ Delta1-pyrroline-5-carboxylate synthetase (P5CS) are required for collagen protein production by lung fibroblasts.	Glutamic Acid	32-41	aldehyde dehydrogenase 18 family member A1	Homo sapiens	105-132
30973753-5	2019	Instead, we discovered that the glutamate-consuming enzymes phosphoserine aminotransferase 1 (PSAT1) and aldehyde dehydrogenase 18A1 (ALDH18A1)/ Delta1-pyrroline-5-carboxylate synthetase (P5CS) are required for collagen protein production by lung fibroblasts.	Glutamic Acid	32-41	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-142
30973753-5	2019	Instead, we discovered that the glutamate-consuming enzymes phosphoserine aminotransferase 1 (PSAT1) and aldehyde dehydrogenase 18A1 (ALDH18A1)/ Delta1-pyrroline-5-carboxylate synthetase (P5CS) are required for collagen protein production by lung fibroblasts.	Glutamic Acid	32-41	aldehyde dehydrogenase 18 family member A1	Homo sapiens	145-186
30973753-5	2019	Instead, we discovered that the glutamate-consuming enzymes phosphoserine aminotransferase 1 (PSAT1) and aldehyde dehydrogenase 18A1 (ALDH18A1)/ Delta1-pyrroline-5-carboxylate synthetase (P5CS) are required for collagen protein production by lung fibroblasts.	Glutamic Acid	32-41	aldehyde dehydrogenase 18 family member A1	Homo sapiens	188-192
30973753-6	2019	PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production.	Proline	93-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	55-63
30973753-6	2019	PSAT1 is required for de novo glycine production while ALDH18A1/P5CS is required for de novo proline production.	Proline	93-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	64-68
30853934-5	2019	P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle.	delta-1-pyrroline-5-carboxylate	60-83	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
30853934-5	2019	P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
30853934-5	2019	P5CS is a critical enzyme in the conversion of glutamate to pyrroline-5-carboxylate, an intermediate that enters in the proline biosynthesis and that is connected with the urea cycle.	Urea	172-176	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-4
28510193-2	2017	In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance.	Proline	83-90	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-15
30367044-6	2018	Some of the novel aberrant gene expression, mutations and core oncogenic pathways identified in cholesterol-associated NASH-HCCs in mice were confirmed in human NASH-HCCs, which included metabolism-related genes (ALDH18A1, CAD, CHKA, POLD4, PSPH and SQLE) and recurrently mutated genes (RYR1, MTOR, SDK1, CACNA1H and RYR2).	Cholesterol	96-107	aldehyde dehydrogenase 18 family member A1	Homo sapiens	213-221
29663544-2	2018	The introduction of an electron-donating substituent in one of the benzene rings of the GSA increased the decomposition temperature by 12 K, which is due to the stronger cation-pi interactions between the benzene ring and positively charged pyridinium rings and tighter molecular meshing between the GSAs in the nanocube.	Benzene	67-74	aldehyde dehydrogenase 18 family member A1	Homo sapiens	300-304
29663544-2	2018	The introduction of an electron-donating substituent in one of the benzene rings of the GSA increased the decomposition temperature by 12 K, which is due to the stronger cation-pi interactions between the benzene ring and positively charged pyridinium rings and tighter molecular meshing between the GSAs in the nanocube.	gsa	88-91	aldehyde dehydrogenase 18 family member A1	Homo sapiens	300-304
29663544-2	2018	The introduction of an electron-donating substituent in one of the benzene rings of the GSA increased the decomposition temperature by 12 K, which is due to the stronger cation-pi interactions between the benzene ring and positively charged pyridinium rings and tighter molecular meshing between the GSAs in the nanocube.	Benzene	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	300-304
29663544-2	2018	The introduction of an electron-donating substituent in one of the benzene rings of the GSA increased the decomposition temperature by 12 K, which is due to the stronger cation-pi interactions between the benzene ring and positively charged pyridinium rings and tighter molecular meshing between the GSAs in the nanocube.	pyridine	241-251	aldehyde dehydrogenase 18 family member A1	Homo sapiens	300-304
29084919-7	2018	Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity.	Proline	49-56	aldehyde dehydrogenase 18 family member A1	Homo sapiens	90-98
29084919-7	2018	Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity.	Hydroxyproline	140-154	aldehyde dehydrogenase 18 family member A1	Homo sapiens	90-98
28510193-2	2017	In plants, P5CS proteins are key enzymes that catalyzed the rate-limiting steps of proline synthesis, and proline is a well-known osmoprotectant that is closely related to abiotic stress tolerance.	Proline	106-113	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-15
28510193-9	2017	However, there should be other P5CS homologues in the lily genome, and some of them could be highly stress-induced and more important for proline accumulation.	Proline	138-145	aldehyde dehydrogenase 18 family member A1	Homo sapiens	31-35
28510193-10	2017	Future studies on P5CS family genes would be of great importance to proline-related stress tolerance in lily.	Proline	68-75	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-22
26082174-4	2015	Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis.	Proline	203-210	aldehyde dehydrogenase 18 family member A1	Homo sapiens	74-117
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Citrulline	111-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Arginine	123-131	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Arginine	123-131	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Proline	137-144	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Proline	137-144	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
26895666-4	2016	Our results showed that expressions of arginine synthesizing enzymes ALDH18A1, ASL, ASS1, CPS1, GLS, OAT and PRODH were significantly decreased in NEC compared with Surg-CTL or SIP tissues.	Arginine	39-47	aldehyde dehydrogenase 18 family member A1	Homo sapiens	69-77
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Ornithine	100-109	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Ornithine	100-109	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-58
26829900-9	2016	ALDH18A1 encodes Delta(1)-pyrroline-5-carboxylate synthase, which is related to the biosynthesis of ornithine, citrulline, arginine, and proline.	Citrulline	111-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26082174-4	2015	Therefore, an RNAi screen of a kinase library was undertaken, identifying aldehyde dehydrogenase 18 family, member A1 (ALDH18A1) as a critically important gene in regulating melanoma cell growth through proline biosynthesis.	Proline	203-210	aldehyde dehydrogenase 18 family member A1	Homo sapiens	119-127
26082174-7	2015	Mechanistically, targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis, which could be reversed with proline supplementation.	Proline	183-190	aldehyde dehydrogenase 18 family member A1	Homo sapiens	27-35
26082174-8	2015	Thus, targeting ALDH18A1 in melanoma can be used to disrupt proline biosynthesis to limit cell metabolism thereby increasing the cellular doubling time mediated through the GCN2 pathway.	Proline	60-67	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-24
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	51-59
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	110-142
26320891-2	2015	They are caused by biallelic mutations in PYCR1 or ALDH18A1, encoding pyrroline-5-carboxylate reductase 1 and pyrroline-5-carboxylate synthase (P5CS), respectively, which both operate in the mitochondrial proline cycle.	Proline	205-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	144-148
26320891-8	2015	Furthermore, we found that the mutant cells had a reduced P5CS enzymatic activity leading to a delayed proline accumulation.	Proline	103-110	aldehyde dehydrogenase 18 family member A1	Homo sapiens	58-62
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-57
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Proline	120-127	aldehyde dehydrogenase 18 family member A1	Homo sapiens	59-63
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-57
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Ornithine	132-141	aldehyde dehydrogenase 18 family member A1	Homo sapiens	59-63
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Glutamic Acid	160-169	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-8
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Glutamic Acid	160-169	aldehyde dehydrogenase 18 family member A1	Homo sapiens	17-57
26026163-3	2015	ALDH18A1 encodes delta-1-pyrroline-5-carboxylate synthase (P5CS), an enzyme that catalyses the first and common step of proline and ornithine biosynthesis from glutamate.	Glutamic Acid	160-169	aldehyde dehydrogenase 18 family member A1	Homo sapiens	59-63
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Ornithine	21-30	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Citrulline	32-42	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Arginine	44-52	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
26026163-6	2015	Low levels of plasma ornithine, citrulline, arginine and proline in four individuals from two families suggested P5CS deficiency.	Proline	57-64	aldehyde dehydrogenase 18 family member A1	Homo sapiens	113-117
26026163-7	2015	Glutamine loading tests in two fibroblast cultures from two related affected subjects confirmed a metabolic block at the level of P5CS in vivo.	Glutamine	0-9	aldehyde dehydrogenase 18 family member A1	Homo sapiens	130-134
25121895-1	2014	We discover deep-subwavelength, low-loss, and diffraction-free surface plasmon polariton (SPP) beam routing effects in aperiodic graphene sheet arrays (a-GSAs).	Graphite	129-137	aldehyde dehydrogenase 18 family member A1	Homo sapiens	154-158
25121895-2	2014	The a-GSAs are constructed by varying either the interlayer spaces between graphene or the individual graphene chemical potentials.	Graphite	75-83	aldehyde dehydrogenase 18 family member A1	Homo sapiens	6-10
25121895-2	2014	The a-GSAs are constructed by varying either the interlayer spaces between graphene or the individual graphene chemical potentials.	Graphite	102-110	aldehyde dehydrogenase 18 family member A1	Homo sapiens	6-10
23493875-2	2013	The GSAS refinement shows that the obtained powder crystallizes as a cubic unit cell with space group I43d, and Mn(2+) ions occupy the Sr(2+) crystallographic sites.	Manganese(2+)	112-118	aldehyde dehydrogenase 18 family member A1	Homo sapiens	4-8
24068435-0	2013	Molecular evolution of plant P5CS gene involved in proline biosynthesis.	Proline	51-58	aldehyde dehydrogenase 18 family member A1	Homo sapiens	29-33
24068435-1	2013	The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms.	Proline	140-147	aldehyde dehydrogenase 18 family member A1	Homo sapiens	4-8
24068435-1	2013	The P5CS ({Delta} 1-Pyrroline-5-Carboxylate Synthetase) gene encodes for a bifunctional enzyme that catalyzes the rate limiting reaction in proline biosynthesis in living organisms.	Proline	140-147	aldehyde dehydrogenase 18 family member A1	Homo sapiens	11-54
24068435-3	2013	The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants.	Proline	4-11	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
24068435-3	2013	The proline biosynthetic genes, especially, P5CS is commonly used in metabolic engineering for proline overproduction conferring stress tolerance in plants.	Proline	95-102	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
20387057-2	2010	The Delta(1)-pyrroline-5-carboxylate synthetase catalyzes the first committed step and the rate-limiting step for proline biosynthesis in both plants and mammals.	Proline	114-121	aldehyde dehydrogenase 18 family member A1	Homo sapiens	4-47
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Polyamines	38-47	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	52-59	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Proline	277-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
23041351-7	2013	Moreover, transcriptional analysis of polyamine and proline metabolism genes (P5CS, P5CR, ADC, SPMS, SPDS, SAMDC, PAO, DAO) further supported the obtained data and revealed a complex SNP concentration-, time-, and developmental stage-dependent mechanism controlling endogenous proline and polyamine metabolite production.	Polyamines	289-298	aldehyde dehydrogenase 18 family member A1	Homo sapiens	78-82
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Ornithine	84-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-43
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Ornithine	84-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-49
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Proline	94-101	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-43
22170564-1	2012	Delta(1)-Pyrroline-5-carboxylate synthetase (P5CS) catalyzes the first two steps of ornithine/proline biosynthesis.	Proline	94-101	aldehyde dehydrogenase 18 family member A1	Homo sapiens	45-49
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Proline	81-88	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Ornithine	89-98	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Citrulline	99-109	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
22170564-3	2012	Only one family exhibited metabolic changes consistent with P5CS deficiency (low proline/ornithine/citrulline/arginine; fasting hyperammonemia).	Arginine	110-118	aldehyde dehydrogenase 18 family member A1	Homo sapiens	60-64
20387057-6	2010	This assay allowed us to determine the optimal pH, the apparent K(m) and V(m) of P5CS with regard to ATP and glutamate.	Adenosine Triphosphate	101-104	aldehyde dehydrogenase 18 family member A1	Homo sapiens	81-85
20387057-6	2010	This assay allowed us to determine the optimal pH, the apparent K(m) and V(m) of P5CS with regard to ATP and glutamate.	Glutamic Acid	109-118	aldehyde dehydrogenase 18 family member A1	Homo sapiens	81-85
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Adenosine Triphosphate	77-80	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Adenosine Triphosphate	77-80	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	nad(p)h	86-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	nad(p)h	86-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Glutamic Acid	196-209	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Glutamic Acid	196-209	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Proline	256-267	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Proline	256-267	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Ornithine	269-282	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Ornithine	269-282	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Arginine	287-299	aldehyde dehydrogenase 18 family member A1	Homo sapiens	10-51
18401542-1	2008	Mammalian Delta(1)-pyrroline-5-carboxylate synthase (P5CS) is a bifunctional ATP- and NAD(P)H-dependent mitochondrial enzyme that catalyzes the coupled phosphorylation and reduction-conversion of L: -glutamate to P5C, a pivotal step in the biosynthesis of L: -proline, L: -ornithine and L: -arginine.	Arginine	287-299	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
18401542-3	2008	The short form (P5CS.short) is highly expressed in the gut and is inhibited by ornithine.	Ornithine	79-88	aldehyde dehydrogenase 18 family member A1	Homo sapiens	16-20
18401542-6	2008	In addition, expression of P5CS.long can be modulated by hormones: downregulation by hydrocortisone and dexamethasone and upregulation by estradiol, for example.	Hydrocortisone	85-99	aldehyde dehydrogenase 18 family member A1	Homo sapiens	27-31
18401542-6	2008	In addition, expression of P5CS.long can be modulated by hormones: downregulation by hydrocortisone and dexamethasone and upregulation by estradiol, for example.	Dexamethasone	104-117	aldehyde dehydrogenase 18 family member A1	Homo sapiens	27-31
18401542-6	2008	In addition, expression of P5CS.long can be modulated by hormones: downregulation by hydrocortisone and dexamethasone and upregulation by estradiol, for example.	Estradiol	138-147	aldehyde dehydrogenase 18 family member A1	Homo sapiens	27-31
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Adenosine Triphosphate	97-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	35-42	aldehyde dehydrogenase 18 family member A1	Homo sapiens	115-119
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Proline	172-179	aldehyde dehydrogenase 18 family member A1	Homo sapiens	115-119
18036351-6	2008	In contrast, overexpression of the proline biosynthetic enzymes Delta(1)-pyrroline-5-carboxylate (P5C) synthetase (P5CS) and P5C reductase (P5CR) resulted in 2-fold higher proline content, significantly lower ROS levels, and increased cell survival relative to control cells.	Reactive Oxygen Species	209-212	aldehyde dehydrogenase 18 family member A1	Homo sapiens	115-119
18036351-7	2008	In different mammalian cell lines exposed to physiological H(2)O(2) levels, increased endogenous P5CS and P5CR expression was observed, indicating that upregulation of proline biosynthesis is an oxidative stress response.	Hydrogen Peroxide	59-67	aldehyde dehydrogenase 18 family member A1	Homo sapiens	97-101
18036351-7	2008	In different mammalian cell lines exposed to physiological H(2)O(2) levels, increased endogenous P5CS and P5CR expression was observed, indicating that upregulation of proline biosynthesis is an oxidative stress response.	Proline	168-175	aldehyde dehydrogenase 18 family member A1	Homo sapiens	97-101
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Ornithine	28-37	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Citrulline	39-49	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Arginine	51-59	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-0	2000	Hyperammonemia with reduced ornithine, citrulline, arginine and proline: a new inborn error caused by a mutation in the gene encoding delta(1)-pyrroline-5-carboxylate synthase.	Proline	64-71	aldehyde dehydrogenase 18 family member A1	Homo sapiens	134-175
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Adenosine Triphosphate	65-68	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Adenosine Triphosphate	65-68	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	NADP	74-79	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	NADP	74-79	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Glutamic Acid	139-148	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Glutamic Acid	139-148	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	delta-1-pyrroline-5-carboxylate	0-32	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	225-232	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	225-232	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	234-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	234-243	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	248-256	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-41
11092761-1	2000	delta(1)-pyrroline-5-carboxylate synthase (P5CS), a bifunctional ATP- and NADPH-dependent mitochondrial enzyme, catalyzes the reduction of glutamate to delta(1)-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	248-256	aldehyde dehydrogenase 18 family member A1	Homo sapiens	43-47
18478038-8	2008	In an in vivo assay of flux through this metabolic pathway using dermal fibroblasts obtained from an affected individual, proline and ornithine biosynthetic activity of P5CS was not affected by the H784Y substitution.	Proline	122-129	aldehyde dehydrogenase 18 family member A1	Homo sapiens	169-173
18478038-8	2008	In an in vivo assay of flux through this metabolic pathway using dermal fibroblasts obtained from an affected individual, proline and ornithine biosynthetic activity of P5CS was not affected by the H784Y substitution.	Ornithine	134-143	aldehyde dehydrogenase 18 family member A1	Homo sapiens	169-173
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Glutamic Acid	86-95	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Glutamic Acid	86-95	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	170-177	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Proline	170-177	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	179-188	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Ornithine	179-188	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	193-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	18-51
15517380-1	2005	UNLABELLED: Delta1-pyrroline-5-carboxylate synthase (P5CS) catalyses the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the biosynthesis of proline, ornithine and arginine.	Arginine	193-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	53-57
15517380-8	2005	Furthermore, we show the results of ornithine loading tests and indirect enzyme studies corroborating the biological significance of the defect in P5CS in vivo.	Ornithine	36-45	aldehyde dehydrogenase 18 family member A1	Homo sapiens	147-151
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Adenosine Triphosphate	97-100	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	NADP	106-111	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	NADP	106-111	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Glutamic Acid	171-180	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Glutamic Acid	171-180	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Proline	263-270	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Proline	263-270	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Ornithine	275-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-39
10037775-10	1999	We found that both confer P5CS activity and that the short isoform is inhibited by L-ornithine with a Ki of approximately 0.25 mM.	Ornithine	83-94	aldehyde dehydrogenase 18 family member A1	Homo sapiens	26-30
10037775-2	1999	Delta1-Pyrroline-5-carboxylate synthase (P5CS; EC not assigned), a mitochondrial inner membrane, ATP- and NADPH-dependent, bifunctional enzyme, catalyzes the reduction of glutamate to Delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline and ornithine.	Ornithine	275-284	aldehyde dehydrogenase 18 family member A1	Homo sapiens	41-45
10037775-12	1999	Thus, the two amino acid insert in the long isoform abolishes feedback inhibition of P5CS activity by L-ornithine.	Ornithine	102-113	aldehyde dehydrogenase 18 family member A1	Homo sapiens	85-89
10037775-7	1999	To confirm the identity of the putative P5CS cDNAs, we expressed both human forms in gamma-glutamyl kinase- and gamma-glutamyl phosphate reductase-deficient strains of Saccharomyces cerevisiae and showed that they conferred the proline prototrophy.	Proline	228-235	aldehyde dehydrogenase 18 family member A1	Homo sapiens	40-44
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Adenosine Triphosphate	74-77	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	nad(p)h	86-93	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Glutamic Acid	118-129	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	gsa	157-160	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
9622938-1	1998	delta 1-pyrroline 5-carboxylate synthetase (P5C synthetase) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamate semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	199-206	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-0	1996	Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis.	Proline	133-140	aldehyde dehydrogenase 18 family member A1	Homo sapiens	23-65
8761662-0	1996	Database cloning human delta 1-pyrroline-5-carboxylate synthetase (P5CS) cDNA: a bifunctional enzyme catalyzing the first 2 steps in proline biosynthesis.	Proline	133-140	aldehyde dehydrogenase 18 family member A1	Homo sapiens	67-71
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Adenosine Triphosphate	64-67	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Adenosine Triphosphate	64-67	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	nad(p)h	76-83	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	nad(p)h	76-83	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Glutamic Acid	108-119	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Glutamic Acid	108-119	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	194-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	0-42
8761662-1	1996	delta 1-pyrroline-5-carboxylate synthetase (P5CS) catalyzes the ATP and the NAD(P)H-dependent conversion of L-glutamate to glutamic gamma-semialdehyde (GSA) which is the metabolic precursor for proline biosynthesis.	Proline	194-201	aldehyde dehydrogenase 18 family member A1	Homo sapiens	44-48
8761662-5	1996	The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine.	Proline	173-180	aldehyde dehydrogenase 18 family member A1	Homo sapiens	42-46
8761662-5	1996	The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine.	Citrulline	182-192	aldehyde dehydrogenase 18 family member A1	Homo sapiens	42-46
8761662-5	1996	The phenotypic features for deficiency of P5CS include joint hyperlaxity, skin hyperelasticity, cataract and mental retardation with hyperammonemia and low plasma levels of proline, citrulline and ornithine.	Ornithine	197-206	aldehyde dehydrogenase 18 family member A1	Homo sapiens	42-46