PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20173760-0	2010	Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes.	SIPI 549	19-38	immunoglobulin lambda variable 2-18	Homo sapiens	48-56
20558140-6	2010	Mutation A130V dramatically decreased the cardiac sodium current density when expressed in HEK293/Na(v)1.5 stable cell line, but did not have significant effect on kinetics of activation, inactivation, and channel recovery from inactivation.	Sodium	50-56	immunoglobulin lambda variable 2-18	Homo sapiens	98-106
20411124-2	2010	Three of them, namely Na(v)1.5, Na(v)1.8, and Na(v)1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC(50) > or = 1 microM).	Tetrodotoxin	101-113	immunoglobulin lambda variable 2-18	Homo sapiens	22-30
20411124-2	2010	Three of them, namely Na(v)1.5, Na(v)1.8, and Na(v)1.9, are resistant to nanomolar concentrations of tetrodotoxin (TTX; IC(50) > or = 1 microM).	Tetrodotoxin	115-118	immunoglobulin lambda variable 2-18	Homo sapiens	22-30
21076026-3	2011	One LQT3 patient carried a mutation in the SCN5A gene in which the cysteine was substituted for a highly conserved tyrosine (Y1767C) located near the cytoplasmic entrance of the Na(v)1.5 channel pore.	Cysteine	67-75	immunoglobulin lambda variable 2-18	Homo sapiens	178-186
21076026-3	2011	One LQT3 patient carried a mutation in the SCN5A gene in which the cysteine was substituted for a highly conserved tyrosine (Y1767C) located near the cytoplasmic entrance of the Na(v)1.5 channel pore.	Tyrosine	115-123	immunoglobulin lambda variable 2-18	Homo sapiens	178-186
20167245-3	2011	Highly metastatic breast cancer cells express Na(V)1.5, the main isoform expressed in cardiac cells, where the current generated by the flux of sodium ions is responsible for the excitability.	Sodium	144-150	immunoglobulin lambda variable 2-18	Homo sapiens	46-54
20618077-1	2010	The sodium channel isoform Na(v)1.5 mediates sodium current, excitability, and electrical conduction in the human heart.	Sodium	4-10	immunoglobulin lambda variable 2-18	Homo sapiens	27-35
20398673-2	2010	The tetrodotoxin (TTX) resistant isoform Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart.	Tetrodotoxin	4-16	immunoglobulin lambda variable 2-18	Homo sapiens	41-49
20398673-2	2010	The tetrodotoxin (TTX) resistant isoform Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart.	Tetrodotoxin	18-21	immunoglobulin lambda variable 2-18	Homo sapiens	41-49
20173760-1	2010	AIM: To investigate the blocking effects of methylflavonolamine (MFA) on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents (I(Na)) in rabbit ventricular myocytes.	SIPI 549	44-63	immunoglobulin lambda variable 2-18	Homo sapiens	79-87
20173760-1	2010	AIM: To investigate the blocking effects of methylflavonolamine (MFA) on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents (I(Na)) in rabbit ventricular myocytes.	SIPI 549	65-68	immunoglobulin lambda variable 2-18	Homo sapiens	79-87
20173760-4	2010	RESULTS: MFA and lidocaine inhibited human Na(V)1.5 channels expressed in Xenopus oocytes in a positive rate-dependent and concentration-dependent manner, with IC(50) values of 72.61 micromol/L and 145.62 micromol/L, respectively.	SIPI 549	9-12	immunoglobulin lambda variable 2-18	Homo sapiens	43-51
20173760-4	2010	RESULTS: MFA and lidocaine inhibited human Na(V)1.5 channels expressed in Xenopus oocytes in a positive rate-dependent and concentration-dependent manner, with IC(50) values of 72.61 micromol/L and 145.62 micromol/L, respectively.	Lidocaine	17-26	immunoglobulin lambda variable 2-18	Homo sapiens	43-51
19875396-1	2010	A patient with an SCN5A p.W822X nonsense mutation, localized in the transmembrane region DII-S4 of the Na(v)1.5 sodium channel and leading to a non-expression of the mutant allele, was prescribed the selective serotonin reuptake inhibitor (SSRI) fluvoxamine (Floxyfral), 100 mg per day.	Fluvoxamine	246-257	immunoglobulin lambda variable 2-18	Homo sapiens	103-111
19861310-1	2010	AIMS: Treatment with the anticancer drug taxol (TXL), which polymerizes the cytoskeleton protein tubulin, may evoke cardiac arrhythmias based on reduced human cardiac sodium channel (Na(v)1.5) function.	Paclitaxel	41-46	immunoglobulin lambda variable 2-18	Homo sapiens	159-191
19861310-7	2010	Accordingly, HEK293 cells and NRCs stained with anti-Na(v)1.5 antibody revealed a reduced membrane-labelling intensity in the TXL-treated groups.	Paclitaxel	126-129	immunoglobulin lambda variable 2-18	Homo sapiens	53-61
19861310-9	2010	Finally, TXL reduced the fraction of channels that slow inactivated from 31% to 18%, and increased the time constant of slow inactivation by two-fold in Na(v)1.5.	Paclitaxel	9-12	immunoglobulin lambda variable 2-18	Homo sapiens	153-161
19875396-1	2010	A patient with an SCN5A p.W822X nonsense mutation, localized in the transmembrane region DII-S4 of the Na(v)1.5 sodium channel and leading to a non-expression of the mutant allele, was prescribed the selective serotonin reuptake inhibitor (SSRI) fluvoxamine (Floxyfral), 100 mg per day.	Fluvoxamine	259-268	immunoglobulin lambda variable 2-18	Homo sapiens	103-111
19279232-3	2009	The sigma(1)-receptor ligands [SKF-10047 and (+)-pentazocine] and sigma(1)/sigma(2)-receptor ligands (haloperidol and ditolylguanidine) all reversibly inhibited Na(v)1.5 channels to varying degrees in human embryonic kidney 293 (HEK-293) cells and COS-7 cells, but the sigma(1)-receptor ligands were less effective in COS-7 cells.	1-(4-azido-2-methylphenyl)-3-(2-methylphenyl)guanidine	118-134	immunoglobulin lambda variable 2-18	Homo sapiens	161-169
19698999-5	2009	Relatively weak inhibition by TTX (30+/-3% at 500nM) and sensitivity to 100microM Zn(2+) suggested that this current was predominantly mediated by the cardiac sodium channel isoform Na(V)1.5.	Tetrodotoxin	30-33	immunoglobulin lambda variable 2-18	Homo sapiens	174-190
19698999-5	2009	Relatively weak inhibition by TTX (30+/-3% at 500nM) and sensitivity to 100microM Zn(2+) suggested that this current was predominantly mediated by the cardiac sodium channel isoform Na(V)1.5.	Zinc	82-84	immunoglobulin lambda variable 2-18	Homo sapiens	174-190
19632629-12	2009	Unexpectedly, the 94-amino-acid fusion peptide derived from the R34fs/60 mutation accentuated the late sodium current of R1195H-containing Na(V)1.5 channels in vitro.	Sodium	103-109	immunoglobulin lambda variable 2-18	Homo sapiens	139-147
19745168-3	2009	OBJECTIVE: Therefore, we tested whether NAD(H) could regulate human cardiac sodium channels (Na(v)1.5).	NAD	40-46	immunoglobulin lambda variable 2-18	Homo sapiens	93-101
19661462-2	2009	A phenylalanine in domain IV, S6 (Phe1759 in Na(V)1.5), modeled to face the inner pore just below the selectivity filter, is critical in use-dependent drug block.	Phenylalanine	2-15	immunoglobulin lambda variable 2-18	Homo sapiens	45-53
19371335-12	2009	CONCLUSIONS AND IMPLICATIONS: We conclude that long-term exposure of cardiomyocytes to bepridil at therapeutic concentrations inhibits calmodulin action, which decreased degradation of the Na(v)1.5 alpha-subunit, which in turn increased Na+ current.	Bepridil	87-95	immunoglobulin lambda variable 2-18	Homo sapiens	189-197
19164297-1	2009	The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br.	Tetrodotoxin	58-70	immunoglobulin lambda variable 2-18	Homo sapiens	128-136
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Phenylalanine	52-55	immunoglobulin lambda variable 2-18	Homo sapiens	220-228
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Isoleucine	62-65	immunoglobulin lambda variable 2-18	Homo sapiens	220-228
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Phenylalanine	72-75	immunoglobulin lambda variable 2-18	Homo sapiens	220-228
19171938-7	2009	Mutation of three consecutive hydrophobic residues (Phe(1520)-Ile(1521)-Phe(1522)) to alanines in this CaM-binding domain recapitulated the electrophysiology phenotype observed with mutation of the C-terminal IQ domain: Na(V)1.5 inactivation was stabilized; moreover, mutations of either CaM-binding domain abolish the well described stabilization of inactivation by lidocaine.	Alanine	86-94	immunoglobulin lambda variable 2-18	Homo sapiens	220-228
19176528-2	2009	MDA-MB-231 breast cancer cells express functional sodium channel complexes, consisting of Na(V)1.5 and associated auxiliary beta-subunits, that are responsible for a sustained inward sodium current at the membrane potential.	Sodium	50-56	immunoglobulin lambda variable 2-18	Homo sapiens	90-98
19164297-1	2009	The synthetic ciguatoxin CTX3C has been shown to activate tetrodotoxin (TTX)-sensitive sodium channels (Na(v)1.2, Na(v)1.4, and Na(v)1.5) by accelerating activation kinetics and shifting the activation curve toward hyperpolarization (Yamaoka, K., Inoue, M., Miyahara, H., Miyazaki, K., and Hirama, M. (2004) Br.	Tetrodotoxin	72-75	immunoglobulin lambda variable 2-18	Homo sapiens	128-136
17060380-11	2006	Electrophysiological analysis of sodium current in HEK293 cells stably expressing hNa(v)1.5 and transiently transfected with wild-type and mutant caveolin-3 demonstrated that mutant caveolin-3 results in a 2- to 3-fold increase in late sodium current compared with wild-type caveolin-3.	Sodium	33-39	immunoglobulin lambda variable 2-18	Homo sapiens	82-91
17935523-1	2007	AIM: Sodium current (I(Na)) of the mammalian heart is resistant to tetrodotoxin (TTX) due to low TTX affinity of the cardiac sodium channel (Na(v)) isoform Na(v)1.5.	Sodium	5-11	immunoglobulin lambda variable 2-18	Homo sapiens	156-164
17935523-1	2007	AIM: Sodium current (I(Na)) of the mammalian heart is resistant to tetrodotoxin (TTX) due to low TTX affinity of the cardiac sodium channel (Na(v)) isoform Na(v)1.5.	Tetrodotoxin	81-84	immunoglobulin lambda variable 2-18	Homo sapiens	156-164
17935523-7	2007	More surprisingly, omNa(v)1.5a also has an aromatic tyrosine in this position, instead of the cysteine of the mammalian TTX-resistant Na(v)1.5.	Tyrosine	52-60	immunoglobulin lambda variable 2-18	Homo sapiens	21-29
17935523-7	2007	More surprisingly, omNa(v)1.5a also has an aromatic tyrosine in this position, instead of the cysteine of the mammalian TTX-resistant Na(v)1.5.	Tetrodotoxin	120-123	immunoglobulin lambda variable 2-18	Homo sapiens	21-29
17510181-2	2007	Concomitantly, lidocaine reduces maximum gating charge (Qmax) by 40% resulting from the complete stabilization of the S4 in domain III in an outward, depolarized position and partial stabilization of the S4 in domain IV in wild-type Na+ channels (Na(V)1.5).	Lidocaine	15-24	immunoglobulin lambda variable 2-18	Homo sapiens	247-255
17070808-1	2006	Molecular modeling predicts that a local anesthetic (LA) lidocaine binds to the resting and open Na(v)1.5 in different modes, interacting with LA-sensing residues known from experiments.	Lidocaine	57-66	immunoglobulin lambda variable 2-18	Homo sapiens	97-105
19133985-10	2009	CONCLUSIONS AND IMPLICATIONS: F 15845 is a selective, potent blocker of the persistent sodium current, generated by the human Na(v)1.5 channel isoforms, and prevents cardiac angina in animal models.	Sodium	87-93	immunoglobulin lambda variable 2-18	Homo sapiens	126-134
19077543-2	2008	Ranolazine, an anti-ischemic drug, has been shown to block cardiac (Na(V)1.5) late sodium current (I(Na)).	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	68-76
19077543-2	2008	Ranolazine, an anti-ischemic drug, has been shown to block cardiac (Na(V)1.5) late sodium current (I(Na)).	Sodium	83-89	immunoglobulin lambda variable 2-18	Homo sapiens	68-76
15831816-3	2005	Sodium currents were acquired by whole cell recording on HEK-293 cells transiently expressing Na(V)1.5.	Sodium	0-6	immunoglobulin lambda variable 2-18	Homo sapiens	94-102
16873405-6	2006	Mutational studies showed that absence of the pH-independent current in Na(V)1.5 could be ascribed to the cysteine in domain I, just above the selectivity filter aspartate (Cys373).	Cysteine	106-114	immunoglobulin lambda variable 2-18	Homo sapiens	72-80
16873405-6	2006	Mutational studies showed that absence of the pH-independent current in Na(V)1.5 could be ascribed to the cysteine in domain I, just above the selectivity filter aspartate (Cys373).	Aspartic Acid	162-171	immunoglobulin lambda variable 2-18	Homo sapiens	72-80
15981012-2	2005	Na(v)1.5 is sensitive to block by cadmium and extracellular QX-314, but relatively insensitive to tetrodotoxin and saxitoxin.	Cadmium	34-41	immunoglobulin lambda variable 2-18	Homo sapiens	0-8
15981012-2	2005	Na(v)1.5 is sensitive to block by cadmium and extracellular QX-314, but relatively insensitive to tetrodotoxin and saxitoxin.	QX-314	60-66	immunoglobulin lambda variable 2-18	Homo sapiens	0-8
15981012-5	2005	Tetrodotoxin sensitivity is largely determined by the identity of a single residue; tyrosine 401 in Na(v)1.4, cysteine 374 in Na(v)1.5 and serine 356 and 355 in Na(v)1.8 and Na(v)1.9.	Tetrodotoxin	0-12	immunoglobulin lambda variable 2-18	Homo sapiens	126-134
15981012-5	2005	Tetrodotoxin sensitivity is largely determined by the identity of a single residue; tyrosine 401 in Na(v)1.4, cysteine 374 in Na(v)1.5 and serine 356 and 355 in Na(v)1.8 and Na(v)1.9.	Cysteine	110-118	immunoglobulin lambda variable 2-18	Homo sapiens	126-134
16930557-5	2006	The results of this study suggest that tyrosine phosphorylation destabilizes the inactivated state of Na(v)1.5.	Tyrosine	39-47	immunoglobulin lambda variable 2-18	Homo sapiens	102-110
16111763-5	2005	Here, we generated an anti-peptide polyclonal antibody, named NESOpAb, which specifically recognised "neonatal" but not "adult" Na(v)1.5 when tested on cells specifically over-expressing one or other of these Na(v)1.5 spliced forms.	nesopab	62-69	immunoglobulin lambda variable 2-18	Homo sapiens	209-217
15790762-3	2005	In humans, a tetrodotoxin-resistant Na+ current (Na(V)1.5) encoded by SCN5A contributes to the rising phase of the slow wave, whereas T-type Ca2+ currents have been reported from cultured mouse intestine ICC and also from canine colonic ICC.	Tetrodotoxin	13-25	immunoglobulin lambda variable 2-18	Homo sapiens	49-57
15831816-8	2005	Tyrosine phosphorylation of immunoprecipitated Na(V)1.5 was increased in cells expressing Fyn(CA) compared with Fyn(KD).	Tyrosine	0-8	immunoglobulin lambda variable 2-18	Homo sapiens	47-55
15485686-5	2004	RESULTS: A novel, spontaneous LQTS-3 mutation was identified in the transmembrane segment 6 of domain IV of the Na(v)1.5 cardiac sodium channel, with a G-->A substitution at codon 1763, which changed a valine (GTG) to a methionine (ATG).	Valine	205-211	immunoglobulin lambda variable 2-18	Homo sapiens	112-120
15548568-8	2005	Using intrinsic tryptophan fluorescence imaging of WW domains, we found that Na(v)1.5 PY motif binds preferentially to the fourth WW domain of Nedd4-2 with a K(d) of approximately 55 muM.	Tryptophan	16-26	immunoglobulin lambda variable 2-18	Homo sapiens	77-85
15548568-12	2005	Finally, using brefeldin A, we found that Nedd4-2 accelerated internalization of Na(v)1.5 stably expressed in HEK-293 cells.	Brefeldin A	15-26	immunoglobulin lambda variable 2-18	Homo sapiens	81-89
15800189-4	2005	Here, we show that I(NaP) conducted by Na(v)1.1 and Na(v)1.2 channels (Na(v)1.1 > Na(v)1.2) is modulated by Gbetagamma; Na(v)1.4 and Na(v)1.5 channels produce smaller I(NaP) that is not regulated by Gbetagamma.	gbetagamma	111-121	immunoglobulin lambda variable 2-18	Homo sapiens	136-144
15800189-4	2005	Here, we show that I(NaP) conducted by Na(v)1.1 and Na(v)1.2 channels (Na(v)1.1 > Na(v)1.2) is modulated by Gbetagamma; Na(v)1.4 and Na(v)1.5 channels produce smaller I(NaP) that is not regulated by Gbetagamma.	gbetagamma	202-212	immunoglobulin lambda variable 2-18	Homo sapiens	136-144
15485686-5	2004	RESULTS: A novel, spontaneous LQTS-3 mutation was identified in the transmembrane segment 6 of domain IV of the Na(v)1.5 cardiac sodium channel, with a G-->A substitution at codon 1763, which changed a valine (GTG) to a methionine (ATG).	Methionine	223-233	immunoglobulin lambda variable 2-18	Homo sapiens	112-120
15485686-10	2004	CONCLUSIONS: These findings suggest that the Na(v)1.5/V1763M channel dysfunction and possible neighboring mutants contribute to a persistent inward current due to altered inactivation kinetics and clinically congenital LQTS with perinatal onset of arrhythmias that responded to lidocaine and mexiletine.	Lidocaine	278-287	immunoglobulin lambda variable 2-18	Homo sapiens	45-53
15485686-10	2004	CONCLUSIONS: These findings suggest that the Na(v)1.5/V1763M channel dysfunction and possible neighboring mutants contribute to a persistent inward current due to altered inactivation kinetics and clinically congenital LQTS with perinatal onset of arrhythmias that responded to lidocaine and mexiletine.	Mexiletine	292-302	immunoglobulin lambda variable 2-18	Homo sapiens	45-53
15217910-5	2004	Yeast two-hybrid and GST-pulldown experiments revealed an interaction between Na(v)1.5 C-terminus and Nedd4-2, which was abrogated by mutating the essential tyrosine of the PY-motif.	Tyrosine	157-165	immunoglobulin lambda variable 2-18	Homo sapiens	78-86
15225632-3	2004	Semi-quantitative PCR analysis revealed that mRNAs for the alpha-subunits of multiple voltage-gated sodium channel subtypes were present but indicated that Na(v)1.5 was the predominant subtype, consistent with the TTX-resistant nature of the recorded currents.	Tetrodotoxin	214-217	immunoglobulin lambda variable 2-18	Homo sapiens	156-164
15066664-3	2004	In this study, we have synthesized novel alpha-hydroxyphenylamide analogues of diphenylhydantoin and examined their ability to inhibit human Na(V)1.5 sodium channels expressed in Chinese Hamster Ovary (CHO-K1) cells.	Phenytoin	79-96	immunoglobulin lambda variable 2-18	Homo sapiens	141-149
15066664-6	2004	In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM.	Phenytoin	17-34	immunoglobulin lambda variable 2-18	Homo sapiens	180-188
15066664-6	2004	In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM.	Sodium Hypochlorite	46-52	immunoglobulin lambda variable 2-18	Homo sapiens	180-188
15066664-6	2004	In comparison to diphenylhydantoin, the novel chloro-substituted alpha-hydroxyphenylamide compounds produced as much as a 20-fold greater tonic and frequency-dependent blockade of Na(V)1.5 channels with an IC(50) value of 14.5 microM.	substituted alpha-hydroxyphenylamide	53-89	immunoglobulin lambda variable 2-18	Homo sapiens	180-188
11786529-9	2002	These results indicate that a positively charged arginine or lysine residue at position 1232 in the double mutant is required for the proper transport and functional expression of the hNa(v)1.5 protein.	Arginine	49-57	immunoglobulin lambda variable 2-18	Homo sapiens	184-193
12068034-0	2002	Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels.	Cocaine	0-7	immunoglobulin lambda variable 2-18	Homo sapiens	61-76
12068034-1	2002	The inhibition by cocaine of the human heart Na+ channel (Na(v)1.5) heterologously expressed in Xenopus oocytes was investigated.	Cocaine	18-25	immunoglobulin lambda variable 2-18	Homo sapiens	45-66
11786529-9	2002	These results indicate that a positively charged arginine or lysine residue at position 1232 in the double mutant is required for the proper transport and functional expression of the hNa(v)1.5 protein.	Lysine	61-67	immunoglobulin lambda variable 2-18	Homo sapiens	184-193
6700337-2	1984	V15 (nasal air flow related to 15 mm H2O) was registered.	Water	37-40	immunoglobulin lambda variable 2-18	Homo sapiens	0-3
30013053-5	2018	Under suitable growth conditions, borophene phases that correspond to the v1/6 and v1/5 models are found to intermix and accommodate line defects in each other with structures that match the constituent units of the other phase.	borophene	34-43	immunoglobulin lambda variable 2-18	Homo sapiens	74-87
30967559-5	2019	Additionally, we show that CO-functionalized scanning tunneling microscopy is an equivalent and more accessible technique for HH imaging, confirming the v1/5 and v1/6 borophene models as unifying structures for all observed phases.	borophene	167-176	immunoglobulin lambda variable 2-18	Homo sapiens	153-166
31369705-4	2020	Interestingly, our data indicated that one candidate aptamer, called V15, can specifically inhibit the in vitro kinase activity of mutant c-KITD816V with an IC50 value that is 9-fold more potent than the sunitinib drug tested under the same conditions.	Sunitinib	204-213	immunoglobulin lambda variable 2-18	Homo sapiens	69-72
30630272-7	2018	For those with PTV overlapping kidney(s), the left kidney V15 was significantly lower with VMAT.	2-[[5-(4-Pyridyl)-1h-1,2,4-Triazol-3-Yl]sulfanyl]-1-(2-Thiophenyl)ethanone	15-18	immunoglobulin lambda variable 2-18	Homo sapiens	58-61
26595809-1	2016	Increased sodium influx via incomplete inactivation of the major cardiac sodium channel Na(V)1.5 is correlated with an increased incidence of atrial fibrillation (AF) in humans.	Sodium	10-16	immunoglobulin lambda variable 2-18	Homo sapiens	88-96
27084642-13	2016	Pencil beam scanning dosimetric gains in the bowel (V15, V20) over VMAT suggest that using PBS to treat rectal cancer may reduce radiation treatment-related toxicity.	pbs	91-94	immunoglobulin lambda variable 2-18	Homo sapiens	52-55
29133136-0	2018	Comparison of the near field/far field model and the advanced reach tool (ART) model V1.5: exposure estimates to benzene during parts washing with mineral spirits.	Benzene	113-120	immunoglobulin lambda variable 2-18	Homo sapiens	85-89
29133136-4	2018	In this study, benzene exposure during the use of a metal parts washer was modeled using ART V1.5, and compared to actual measured workers samples and to NF/FF model results from three previous studies.	Benzene	15-22	immunoglobulin lambda variable 2-18	Homo sapiens	93-97
23283979-7	2013	These data suggest that Cys-373 and His-880 in Na(V)1.5 are proton sensors for use-dependent and slow inactivation and have implications in isoform-specific modulation of Na(V) channels.	Cysteine	24-27	immunoglobulin lambda variable 2-18	Homo sapiens	47-55
25815641-2	2015	Recently, calcium (Ca(2+))/calmodulin(CaM)-dependent protein kinase II (CaMKII) has emerged as a critical regulator of Na(V)1.5 function through phosphorylation of multiple residues including S516, T594, and S571, and these phosphorylation events may be important for the genesis of acquired arrhythmias, which occur in heart failure.	Calcium	10-17	immunoglobulin lambda variable 2-18	Homo sapiens	119-127
25496128-6	2014	CONCLUSIONS: Taken together, our results demonstrate the importance of Na(V)1.5 in the metastatic colonisation of organs by breast cancer cells and indicate that small molecules interfering with Na(V) activity, such as ranolazine, may represent powerful pharmacological tools to inhibit metastatic development and improve cancer treatments.	Ranolazine	219-229	immunoglobulin lambda variable 2-18	Homo sapiens	71-79
24117196-0	2014	The opioid methadone induces a local anaesthetic-like inhibition of the cardiac Na+ channel, Na(v)1.5.	Methadone	11-20	immunoglobulin lambda variable 2-18	Homo sapiens	93-101
24117196-3	2014	Considering the common assumption that an inhibition of the cardiac Na+ channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.	Methadone	187-196	immunoglobulin lambda variable 2-18	Homo sapiens	80-88
24117196-3	2014	Considering the common assumption that an inhibition of the cardiac Na+ channel Na(v)1.5, is the primary mechanism for local anaesthetic (LA)-induced cardiotoxicity, we hypothesized that methadone has LA-like properties leading to a modulation of Na(v)1.5 channels.	Methadone	187-196	immunoglobulin lambda variable 2-18	Homo sapiens	247-255
24117196-4	2014	EXPERIMENTAL APPROACH: The whole-cell patch clamp technique was applied to investigate the effects of methadone on wild-type and mutant human Na(v)1.5 channels expressed in HEK293 cells.	Methadone	102-111	immunoglobulin lambda variable 2-18	Homo sapiens	142-150
24117196-6	2014	KEY RESULTS: Methadone inhibited Na(v)1.5 channels in a state-dependent manner, that is, tonic block was stronger with inactivated channels than with resting channels and a use-dependent block at 10 Hz.	Methadone	13-22	immunoglobulin lambda variable 2-18	Homo sapiens	33-41
24117196-9	2014	Dextromethadone and levomethadone induced discrete stereo-selective effects on Na(v)1.5 channels.	D-methadone	0-15	immunoglobulin lambda variable 2-18	Homo sapiens	79-87
24117196-9	2014	Dextromethadone and levomethadone induced discrete stereo-selective effects on Na(v)1.5 channels.	Levomethadone	20-33	immunoglobulin lambda variable 2-18	Homo sapiens	79-87
24117196-10	2014	CONCLUSIONS AND IMPLICATIONS: Methadone interacted with the LA-binding site to inhibit Na(v)1.5 channels.	Methadone	30-39	immunoglobulin lambda variable 2-18	Homo sapiens	87-95
25496128-4	2014	Furthermore, we demonstrated that ranolazine (50 muM) inhibited Na(V)1.5 currents in breast cancer cells and reduced Na(V)1.5-related cancer cell invasiveness in vitro.	Ranolazine	34-44	immunoglobulin lambda variable 2-18	Homo sapiens	64-72
25496128-4	2014	Furthermore, we demonstrated that ranolazine (50 muM) inhibited Na(V)1.5 currents in breast cancer cells and reduced Na(V)1.5-related cancer cell invasiveness in vitro.	Ranolazine	34-44	immunoglobulin lambda variable 2-18	Homo sapiens	117-125
25496128-5	2014	In vivo, the injection of ranolazine (50 mg/kg/day) significantly reduced lung colonisation by Na(V)1.5-expressing human breast cancer cells.	Ranolazine	26-36	immunoglobulin lambda variable 2-18	Homo sapiens	95-103
23283979-7	2013	These data suggest that Cys-373 and His-880 in Na(V)1.5 are proton sensors for use-dependent and slow inactivation and have implications in isoform-specific modulation of Na(V) channels.	Histidine	36-39	immunoglobulin lambda variable 2-18	Homo sapiens	47-55
24555036-4	2013	METHODS: In this short study, we (1) compared the biophysical properties of the sodium current (I Na) generated by the mouse Na v1.5 (mNa v1.5) and human Na v1.5 (hNa v1.5) constructs that were expressed in HEK293 cells, and (2) investigated the possible alterations of the biophysical properties of the human Na v1.5 construct that was modified with specific epitopes.	Sodium	80-86	immunoglobulin lambda variable 2-18	Homo sapiens	128-132
24555036-4	2013	METHODS: In this short study, we (1) compared the biophysical properties of the sodium current (I Na) generated by the mouse Na v1.5 (mNa v1.5) and human Na v1.5 (hNa v1.5) constructs that were expressed in HEK293 cells, and (2) investigated the possible alterations of the biophysical properties of the human Na v1.5 construct that was modified with specific epitopes.	Sodium	80-86	immunoglobulin lambda variable 2-18	Homo sapiens	138-142
23104914-4	2012	Furthermore, we stably expressed mutant Na(v)1.5 [A1924T (fast sodium channel mutant (substitution of alanine by threonine at amino acid 1924)] channels with hyperpolarized steady-state activation and showed that, despite a 71.6% reduction in peak I(Na), these cells propagated APs at the same velocity as the wild-type Na(v)1.5-expressing Ex-293 cells.	Adenosine Phosphosulfate	278-281	immunoglobulin lambda variable 2-18	Homo sapiens	40-48
23018927-3	2012	Recently, ranolazine was also shown to be an inhibitor of Na(V)1.5 mechanosensitivity.	Ranolazine	10-20	immunoglobulin lambda variable 2-18	Homo sapiens	58-66
22802584-8	2012	Accordingly, half of the current was blocked by 1 mum of tetrodotoxin and immunocytochemistry experiments reveal the presence of Na(v)1.5 proteins.	Tetrodotoxin	57-69	immunoglobulin lambda variable 2-18	Homo sapiens	129-137
22929165-10	2012	Disruption of cytoskeletal networks with 5-iodonaphthalene-1-sulfonyl homopiperazine and cytochalasin D abolished the effects of ZASP1-D117N on Na(v)1.5.	ML 7	41-84	immunoglobulin lambda variable 2-18	Homo sapiens	144-152
22929165-10	2012	Disruption of cytoskeletal networks with 5-iodonaphthalene-1-sulfonyl homopiperazine and cytochalasin D abolished the effects of ZASP1-D117N on Na(v)1.5.	Cytochalasin D	89-103	immunoglobulin lambda variable 2-18	Homo sapiens	144-152
22400069-8	2012	In the present study, we determined whether Foxo1 regulates Na(V)1.5 expression at the transcriptional level and also defined the role of Foxo1 in hydrogen peroxide (H(2)O(2))-mediated Na(V)1.5 suppression in HL-1 cardiomyocytes using chromatin immunoprecipitation (ChIP), constitutively nuclear Foxo1 expression, and RNAi Foxo1 knockdown as well as whole cell voltage-clamp recordings.	Hydrogen Peroxide	147-164	immunoglobulin lambda variable 2-18	Homo sapiens	185-193
22934003-5	2012	DHA and EPA also decrease the magnitude of the currents elicited by the activation of Na(v)1.5 and calcium channels.	dehydroacetic acid	0-3	immunoglobulin lambda variable 2-18	Homo sapiens	86-94
22874086-10	2012	Lidocaine inhibited mechanosensitivity in Na(V)1.5 at the local anesthetic binding site mutated (F1760A).	Lidocaine	0-9	immunoglobulin lambda variable 2-18	Homo sapiens	42-50
22514276-10	2012	CaMKII-dependent phosphorylation of Na(V)1.5 at multiple sites (including Thr-594 and Ser-516) appears to be required to evoke loss-of-function changes in gating that could contribute to acquired Brugada syndrome-like effects in heart failure.	Threonine	74-77	immunoglobulin lambda variable 2-18	Homo sapiens	36-44
22514276-10	2012	CaMKII-dependent phosphorylation of Na(V)1.5 at multiple sites (including Thr-594 and Ser-516) appears to be required to evoke loss-of-function changes in gating that could contribute to acquired Brugada syndrome-like effects in heart failure.	Serine	86-89	immunoglobulin lambda variable 2-18	Homo sapiens	36-44
22565935-0	2012	Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	80-88
22565935-2	2012	Ranolazine is a Na(V)1.5 antagonist with antianginal and antiarrhythmic properties.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	16-24
22565935-9	2012	Block of Na(V)1.5 mechanosensitivity by ranolazine was not due to the known binding site on DIVS6 (F1760).	Ranolazine	40-50	immunoglobulin lambda variable 2-18	Homo sapiens	9-17
22565935-10	2012	The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidocaine.	Ranolazine	14-24	immunoglobulin lambda variable 2-18	Homo sapiens	50-58
22565935-10	2012	The effect of ranolazine on mechanosensitivity of Na(V)1.5 was approximated by lidocaine.	Lidocaine	79-88	immunoglobulin lambda variable 2-18	Homo sapiens	50-58
22565935-12	2012	CONCLUSIONS: Ranolazine effectively inhibits mechanosensitivity of Na(V)1.5.	Ranolazine	13-23	immunoglobulin lambda variable 2-18	Homo sapiens	67-75
22565935-13	2012	The block of Na(V)1.5 mechanosensitivity by ranolazine does not utilize the established binding site and may require bilayer partitioning.	Ranolazine	44-54	immunoglobulin lambda variable 2-18	Homo sapiens	13-21
22565935-14	2012	Ranolazine block of Na(V)1.5 mechanosensitivity may be relevant in disorders of mechanoelectric dysfunction.	Ranolazine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	20-28
22052157-4	2012	Specifically, we compute the fast Fourier transform for a family of current traces at different step potentials for the inward rectifying potassium channel, K(ir)2.1, and the channel encoding the cardiac fast sodium current, Na(v)1.5.	Sodium	209-215	immunoglobulin lambda variable 2-18	Homo sapiens	225-233
23003928-3	2012	The ground-state quantum coherence and Rabi oscillations of the SMM V15 ([V15(IV)As6(III)O42(H2O)]6-) have been studied in this context.	Water	93-96	immunoglobulin lambda variable 2-18	Homo sapiens	68-71
22400069-12	2012	These studies indicate that Foxo1 negatively regulates Na(V)1.5 expression in cardiomyocytes and reactive oxygen species suppress Na(V)1.5 expression through Foxo1.	Reactive Oxygen Species	97-120	immunoglobulin lambda variable 2-18	Homo sapiens	130-138
21922571-0	2011	Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.	Saxitoxin	35-44	immunoglobulin lambda variable 2-18	Homo sapiens	137-145
21616062-0	2011	Inhibition of human Na(v)1.5 sodium channels by strychnine and its analogs.	Strychnine	48-58	immunoglobulin lambda variable 2-18	Homo sapiens	20-28
21922571-5	2011	Uniquely, however, the inhibition of Na(V)1.5 by (-)-FD-dcSTX (4b) was "irreversible".	(-)-fd-dcstx	49-61	immunoglobulin lambda variable 2-18	Homo sapiens	37-45
21840964-6	2011	Importantly, we also expressed the peptide spanning the H558R polymorphism with 8 additional BrS Na(v)1.5 mutations with reduced currents and demonstrated that the peptide was able to restore significant sodium currents in 4 of them.	Sodium	204-210	immunoglobulin lambda variable 2-18	Homo sapiens	97-105
21616062-2	2011	In this study, we have characterized the pharmacological properties of strychnine and its analogs on human Na(v)1.5 channels to assess their potential therapeutic advantage in certain arrhythmias.	Strychnine	71-81	immunoglobulin lambda variable 2-18	Homo sapiens	107-115
21616062-3	2011	Among the eight alkaloids, only strychnine and icajine exhibited inhibition potency on the Na(v)1.5 channel with the half-maximum inhibition (IC(50)) values of 83.1muM and 104.6muM, respectively.	Alkaloids	16-25	immunoglobulin lambda variable 2-18	Homo sapiens	91-99
21616062-3	2011	Among the eight alkaloids, only strychnine and icajine exhibited inhibition potency on the Na(v)1.5 channel with the half-maximum inhibition (IC(50)) values of 83.1muM and 104.6muM, respectively.	Strychnine	32-42	immunoglobulin lambda variable 2-18	Homo sapiens	91-99
21616062-3	2011	Among the eight alkaloids, only strychnine and icajine exhibited inhibition potency on the Na(v)1.5 channel with the half-maximum inhibition (IC(50)) values of 83.1muM and 104.6muM, respectively.	icajine	47-54	immunoglobulin lambda variable 2-18	Homo sapiens	91-99
21616062-7	2011	Strychnine and icajine bind to the Na(v)1.5 channel with a new mechanism that is different from TTX and local anesthetics.	Strychnine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	35-43
21616062-7	2011	Strychnine and icajine bind to the Na(v)1.5 channel with a new mechanism that is different from TTX and local anesthetics.	icajine	15-22	immunoglobulin lambda variable 2-18	Homo sapiens	35-43
21616062-7	2011	Strychnine and icajine bind to the Na(v)1.5 channel with a new mechanism that is different from TTX and local anesthetics.	Tetrodotoxin	96-99	immunoglobulin lambda variable 2-18	Homo sapiens	35-43
21616062-9	2011	Strychnine and icajine had little effect on steady-state fast inactivation but markedly shifted the slow inactivation of Na(v)1.5 currents toward more hyperpolarized potentials.	Strychnine	0-10	immunoglobulin lambda variable 2-18	Homo sapiens	121-129
21616062-9	2011	Strychnine and icajine had little effect on steady-state fast inactivation but markedly shifted the slow inactivation of Na(v)1.5 currents toward more hyperpolarized potentials.	icajine	15-22	immunoglobulin lambda variable 2-18	Homo sapiens	121-129
21616062-10	2011	The property of icajine influencing slow-inactivated state of Na(v)1.5 channel would be potential therapeutic advantages in certain arrhythmias.	icajine	16-23	immunoglobulin lambda variable 2-18	Homo sapiens	62-70
21726068-5	2011	We report the identification of arginine methylation as a novel post-translational modification of Na(v)1.5.	Arginine	32-40	immunoglobulin lambda variable 2-18	Homo sapiens	99-107
21726068-7	2011	The functional relevance of arginine methylation in Na(v)1.5 is underscored by the fact that R526H and R680H are known Na(v)1.5 mutations causing Brugada and long QT type 3 syndromes, respectively.	Arginine	28-36	immunoglobulin lambda variable 2-18	Homo sapiens	52-60
21726068-7	2011	The functional relevance of arginine methylation in Na(v)1.5 is underscored by the fact that R526H and R680H are known Na(v)1.5 mutations causing Brugada and long QT type 3 syndromes, respectively.	Arginine	28-36	immunoglobulin lambda variable 2-18	Homo sapiens	119-127
21170089-1	2011	Na(V)1.5 sodium channels enhance the invasiveness of breast cancer cells through the acidic-dependent activation of cysteine cathepsins.	Cysteine	116-124	immunoglobulin lambda variable 2-18	Homo sapiens	0-8
21419143-8	2011	The latter was largely accounted for by the alteration in the TTX-binding site (Tyr401 in rNa(V)1.4, Cys for Na(V)1.5, and Ser for Na(V)1.8).	Tetrodotoxin	62-65	immunoglobulin lambda variable 2-18	Homo sapiens	109-117
21419143-8	2011	The latter was largely accounted for by the alteration in the TTX-binding site (Tyr401 in rNa(V)1.4, Cys for Na(V)1.5, and Ser for Na(V)1.8).	Cysteine	101-104	immunoglobulin lambda variable 2-18	Homo sapiens	109-117
21393430-4	2011	The aims of this study were to determine the effects of the H(2)S donor NaHS on Na(V)1.5, a voltage-dependent sodium channel expressed in the gastrointestinal tract in human jejunum smooth muscle cells and interstitial cells of Cajal, and to elucidate whether H(2)S acts on Na(V)1.5 by redox reactions.	Hydrogen Sulfide	60-65	immunoglobulin lambda variable 2-18	Homo sapiens	80-88
21393430-4	2011	The aims of this study were to determine the effects of the H(2)S donor NaHS on Na(V)1.5, a voltage-dependent sodium channel expressed in the gastrointestinal tract in human jejunum smooth muscle cells and interstitial cells of Cajal, and to elucidate whether H(2)S acts on Na(V)1.5 by redox reactions.	sodium bisulfide	72-76	immunoglobulin lambda variable 2-18	Homo sapiens	80-88
21393430-4	2011	The aims of this study were to determine the effects of the H(2)S donor NaHS on Na(V)1.5, a voltage-dependent sodium channel expressed in the gastrointestinal tract in human jejunum smooth muscle cells and interstitial cells of Cajal, and to elucidate whether H(2)S acts on Na(V)1.5 by redox reactions.	Hydrogen Sulfide	260-265	immunoglobulin lambda variable 2-18	Homo sapiens	80-88
21393430-11	2011	Pretreatment with the Hg(2+)-conjugated oxidizer thimerosal or the alkylating agent N-ethylmaleimide inhibited or decreased NaHS induction of Na(V)1.5 peak current.	Thimerosal	49-59	immunoglobulin lambda variable 2-18	Homo sapiens	142-150
21393430-11	2011	Pretreatment with the Hg(2+)-conjugated oxidizer thimerosal or the alkylating agent N-ethylmaleimide inhibited or decreased NaHS induction of Na(V)1.5 peak current.	Ethylmaleimide	84-100	immunoglobulin lambda variable 2-18	Homo sapiens	142-150
21393430-11	2011	Pretreatment with the Hg(2+)-conjugated oxidizer thimerosal or the alkylating agent N-ethylmaleimide inhibited or decreased NaHS induction of Na(V)1.5 peak current.	sodium bisulfide	124-128	immunoglobulin lambda variable 2-18	Homo sapiens	142-150
21167176-1	2011	The function of the human voltage-gated sodium channel Na(V)1.5 is regulated in part by intracellular calcium signals.	Calcium	102-109	immunoglobulin lambda variable 2-18	Homo sapiens	55-63
21167176-2	2011	The ubiquitous calcium sensor protein calmodulin (CaM) is an important part of the complex calcium-sensing apparatus in Na(V)1.5.	Calcium	15-22	immunoglobulin lambda variable 2-18	Homo sapiens	120-128
21167176-7	2011	Sequence similarities between voltage-gated sodium channels and voltage-gated calcium channels suggest that the structure of the CaM-Na(V)1.5 IQ motif complex can serve as a general model for the interaction between CaM and ion channel IQ motifs under low-calcium conditions.	Calcium	78-85	immunoglobulin lambda variable 2-18	Homo sapiens	133-141