PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 16141203-5 2005 We also expressed ACOT8, another peroxisomal acyl-CoA thioesterase that was previously shown to hydrolyze a large variety of CoA esters. coa esters 125-135 acyl-CoA thioesterase 8 Homo sapiens 18-23 16141203-7 2005 Enzyme activity measurements with expressed ACOT4 and ACOT8 show that both enzymes hydrolyze CoA esters of dicarboxylic acids with high activity but with strikingly different specificities. Coenzyme A 93-96 acyl-CoA thioesterase 8 Homo sapiens 54-59 16141203-7 2005 Enzyme activity measurements with expressed ACOT4 and ACOT8 show that both enzymes hydrolyze CoA esters of dicarboxylic acids with high activity but with strikingly different specificities. Esters 97-103 acyl-CoA thioesterase 8 Homo sapiens 54-59 16141203-7 2005 Enzyme activity measurements with expressed ACOT4 and ACOT8 show that both enzymes hydrolyze CoA esters of dicarboxylic acids with high activity but with strikingly different specificities. Dicarboxylic Acids 107-125 acyl-CoA thioesterase 8 Homo sapiens 54-59 16141203-8 2005 Whereas ACOT4 mainly hydrolyzes succinyl-CoA, ACOT8 preferentially hydrolyzes longer dicarboxylyl-CoA esters (glutaryl-CoA, adipyl-CoA, suberyl-CoA, sebacyl-CoA, and dodecanedioyl-CoA). dicarboxylyl-coa esters 85-108 acyl-CoA thioesterase 8 Homo sapiens 46-51 16141203-8 2005 Whereas ACOT4 mainly hydrolyzes succinyl-CoA, ACOT8 preferentially hydrolyzes longer dicarboxylyl-CoA esters (glutaryl-CoA, adipyl-CoA, suberyl-CoA, sebacyl-CoA, and dodecanedioyl-CoA). glutaryl-coenzyme A 110-122 acyl-CoA thioesterase 8 Homo sapiens 46-51 16141203-8 2005 Whereas ACOT4 mainly hydrolyzes succinyl-CoA, ACOT8 preferentially hydrolyzes longer dicarboxylyl-CoA esters (glutaryl-CoA, adipyl-CoA, suberyl-CoA, sebacyl-CoA, and dodecanedioyl-CoA). sebacyl-coa 149-160 acyl-CoA thioesterase 8 Homo sapiens 46-51 16141203-8 2005 Whereas ACOT4 mainly hydrolyzes succinyl-CoA, ACOT8 preferentially hydrolyzes longer dicarboxylyl-CoA esters (glutaryl-CoA, adipyl-CoA, suberyl-CoA, sebacyl-CoA, and dodecanedioyl-CoA). Dodecanedioyl-CoA 166-183 acyl-CoA thioesterase 8 Homo sapiens 46-51 16141203-9 2005 The identification of a highly specific succinyl-CoA thioesterase in peroxisomes strongly suggests that peroxisomal beta-oxidation of dicarboxylic acids leads to formation of succinate, at least under certain conditions, and that ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids. Dicarboxylic Acids 134-152 acyl-CoA thioesterase 8 Homo sapiens 240-245 16141203-9 2005 The identification of a highly specific succinyl-CoA thioesterase in peroxisomes strongly suggests that peroxisomal beta-oxidation of dicarboxylic acids leads to formation of succinate, at least under certain conditions, and that ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids. Succinic Acid 175-184 acyl-CoA thioesterase 8 Homo sapiens 240-245 15210697-4 2004 In hTE H(+) secretion was blocked by mucosal ZnCl(2) and the NADPH oxidase blockers acetovanillone and 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), whereas these same blockers had no effect in Calu-3. zncl 45-49 acyl-CoA thioesterase 8 Homo sapiens 3-6 15210697-4 2004 In hTE H(+) secretion was blocked by mucosal ZnCl(2) and the NADPH oxidase blockers acetovanillone and 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), whereas these same blockers had no effect in Calu-3. acetovanillone 84-98 acyl-CoA thioesterase 8 Homo sapiens 3-6 15210697-4 2004 In hTE H(+) secretion was blocked by mucosal ZnCl(2) and the NADPH oxidase blockers acetovanillone and 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), whereas these same blockers had no effect in Calu-3. 4-(2-aminoethyl)benzenesulfonylfluoride 103-143 acyl-CoA thioesterase 8 Homo sapiens 3-6 15210697-4 2004 In hTE H(+) secretion was blocked by mucosal ZnCl(2) and the NADPH oxidase blockers acetovanillone and 4-(2-aminoethyl)benzenesulfonyl fluoride (AEBSF), whereas these same blockers had no effect in Calu-3. 4-(2-aminoethyl)benzenesulfonylfluoride 145-150 acyl-CoA thioesterase 8 Homo sapiens 3-6 15210697-8 2004 When treated with amiloride to block the Na(+)/H(+) exchanger, intracellular pH in hTE acidified at significantly higher rates than in Calu-3, and treatment with AEBSF blocked acidification. Amiloride 18-27 acyl-CoA thioesterase 8 Homo sapiens 83-86 15210697-8 2004 When treated with amiloride to block the Na(+)/H(+) exchanger, intracellular pH in hTE acidified at significantly higher rates than in Calu-3, and treatment with AEBSF blocked acidification. 4-(2-aminoethyl)benzenesulfonylfluoride 162-167 acyl-CoA thioesterase 8 Homo sapiens 83-86 6108603-1 1980 The intracellular localization studies of human blood platelets by sucrose gradient and differential centrifugation, showed that palmitoyl-CoA hydrolase was mainly localized in the cytosol fraction. Sucrose 67-74 acyl-CoA thioesterase 8 Homo sapiens 129-152 9299485-5 1997 hACTE-III exhibits enzymatic specificity for a broad range of fatty acyl-CoAs. Acyl Coenzyme A 62-77 acyl-CoA thioesterase 8 Homo sapiens 0-9 9299485-8 1997 Considering that either Nef-overexpression or impaired fatty acid regulation induces alteration of subcellular morphology, the augmented hACTE-III function by Nef-binding might induce dysfunction of T cells. Fatty Acids 55-65 acyl-CoA thioesterase 8 Homo sapiens 137-146 8579357-6 1996 In the rat brain cytosol, about 90% of palmitoyl-CoA hydrolase activity was titrated by anti-ACH antibody, which accounted for over 70% of the enzyme activity found in the brain tissue. Acetylcholine 93-96 acyl-CoA thioesterase 8 Homo sapiens 39-62 8276823-2 1994 Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue. Serine 109-112 acyl-CoA thioesterase 8 Homo sapiens 92-107 8276823-2 1994 Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue. Histidine 171-174 acyl-CoA thioesterase 8 Homo sapiens 92-107 8276823-2 1994 Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue. Hydrogen 195-203 acyl-CoA thioesterase 8 Homo sapiens 92-107 8276823-2 1994 Two residues are known to play important catalytic roles in fatty acyl-thioester hydrolase, thioesterase II: Ser-101, the site of a covalent acyl-enzyme intermediate, and His-237 which is within hydrogen bonding distance of Ser-101 and facilitates catalysis by increasing the nucleophilicity of this residue. Serine 224-227 acyl-CoA thioesterase 8 Homo sapiens 92-107 6589427-1 1984 Metabolic, enzymologic, and immunohistochemical techniques have been used to show that a human cell line of breast epithelial origin synthesized medium chain fatty acids via the ubiquitous fatty acid synthetase and a mammary-specific chain-terminating enzyme, thioesterase II. medium chain fatty acids 145-169 acyl-CoA thioesterase 8 Homo sapiens 260-275 10807905-4 2000 Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123). Aspartic Acid 79-82 acyl-CoA thioesterase 8 Homo sapiens 23-26 10807905-4 2000 Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123). Leucine 89-92 acyl-CoA thioesterase 8 Homo sapiens 23-26 10807905-4 2000 Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123). Phenylalanine 99-102 acyl-CoA thioesterase 8 Homo sapiens 23-26 10807905-4 2000 Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123). Proline 109-112 acyl-CoA thioesterase 8 Homo sapiens 23-26 10807905-4 2000 Interaction of Nef and hTE was abolished by point mutations in Nef at residues Asp(108), Leu(112), Phe(121), Pro(122), and Asp(123). Aspartic Acid 123-126 acyl-CoA thioesterase 8 Homo sapiens 23-26 6103716-1 1980 The ability or inability of certain rodent mammary adenocarcinomas to synthesize medium chain fatty acids in vitro, correlates with the presence or absence of the specific mammary chain-terminating enzyme, thioesterase II. medium chain fatty acids 81-105 acyl-CoA thioesterase 8 Homo sapiens 206-221 28536676-6 2017 Alanine mutants of basic and aromatic residues on HTE20N significantly reduced binding to the LigB. Alanine 0-7 acyl-CoA thioesterase 8 Homo sapiens 50-56 32785370-0 2020 Structure-properties relationship in the hydronium-containing pyrochlores (H3O)1+pSb1+pTe1-pO6 with catalytic activity in the fructose dehydration reaction. Hydronium 41-50 acyl-CoA thioesterase 8 Homo sapiens 86-90 32785370-0 2020 Structure-properties relationship in the hydronium-containing pyrochlores (H3O)1+pSb1+pTe1-pO6 with catalytic activity in the fructose dehydration reaction. pyrochlore 62-73 acyl-CoA thioesterase 8 Homo sapiens 86-90 32785370-0 2020 Structure-properties relationship in the hydronium-containing pyrochlores (H3O)1+pSb1+pTe1-pO6 with catalytic activity in the fructose dehydration reaction. h3o 75-78 acyl-CoA thioesterase 8 Homo sapiens 86-90 32785370-1 2020 A series of defect pyrochlores of the composition (H3O)1+pSb1+pTe1-pO6 have been prepared by ion exchange from K-containing pyrochlores K1+pSb1+pTe1-pO6 in sulfuric acid at 280 C for 24 h. The structural characterization of the hydronium-containing pyrochlores, including the location of the H3O+ units within the three-dimensional framework, was possible from neutron powder diffraction data in undeuterated samples. pyrochlore 19-30 acyl-CoA thioesterase 8 Homo sapiens 62-66 32785370-1 2020 A series of defect pyrochlores of the composition (H3O)1+pSb1+pTe1-pO6 have been prepared by ion exchange from K-containing pyrochlores K1+pSb1+pTe1-pO6 in sulfuric acid at 280 C for 24 h. The structural characterization of the hydronium-containing pyrochlores, including the location of the H3O+ units within the three-dimensional framework, was possible from neutron powder diffraction data in undeuterated samples. pyrochlore 19-30 acyl-CoA thioesterase 8 Homo sapiens 144-148 31731693-2 2019 This in vitro study aimed to investigate the role of Hypericum triquetrifolium (50% ethanol: 50% water) extract (HTE) treatment on apoptosis, cell cycle modulation, and cell cycle arrest in human colon cancer cell line (HCT-116). Ethanol 84-91 acyl-CoA thioesterase 8 Homo sapiens 113-116 26927806-7 2016 Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association. Arginine 72-75 acyl-CoA thioesterase 8 Homo sapiens 66-71 26927806-7 2016 Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association. Phenylalanine 80-83 acyl-CoA thioesterase 8 Homo sapiens 66-71 26927806-7 2016 Coimmunoprecipitation and immunofluorescence analyses showed that ACOT8 Arg(45)-Phe(55) and Arg(86)-Pro(93) regions are involved in Nef association. Proline 100-103 acyl-CoA thioesterase 8 Homo sapiens 66-71 23540296-6 2013 Acyl-CoA thioesterase 8 isoform c (ACOT8) was one of most overexpressed proteins in the metastatic group, and it was validated by Western blot and immunohistochemical staining on 108 paraffin-embedded tumor samples. Paraffin 183-191 acyl-CoA thioesterase 8 Homo sapiens 0-23 23540296-6 2013 Acyl-CoA thioesterase 8 isoform c (ACOT8) was one of most overexpressed proteins in the metastatic group, and it was validated by Western blot and immunohistochemical staining on 108 paraffin-embedded tumor samples. Paraffin 183-191 acyl-CoA thioesterase 8 Homo sapiens 35-40 19473986-6 2009 The LigB immunoglobulin-like domain binds to the 17th to 27th exons of HTE (17-27HTE) as determined by ELISA (LigBCon4, K(D) = 0.50 microm; LigBCen7"-8, K(D) = 0.82 microm; LigBCen9, K(D) = 1.54 microm; and LigBCen12, K(D) = 0.73 microm). 17-27hte 76-84 acyl-CoA thioesterase 8 Homo sapiens 71-74