PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 32877255-2 2020 Lanosterol synthase (LSS) and 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) are the limiting enzymes in the process of synthesis of lanosterol. Lanosterol 142-152 lanosterol synthase Homo sapiens 0-19 32986402-7 2020 All the anisotropic OSC molecules grown on poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate (PEDOT:PSS) electrodes show a greater degree of molecular ordering than those grown on Au and multiwalled carbon nanotube/PEDOT:PSS electrodes. poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) 43-97 lanosterol synthase Homo sapiens 20-23 32986402-7 2020 All the anisotropic OSC molecules grown on poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate (PEDOT:PSS) electrodes show a greater degree of molecular ordering than those grown on Au and multiwalled carbon nanotube/PEDOT:PSS electrodes. pedot 99-104 lanosterol synthase Homo sapiens 20-23 32986402-7 2020 All the anisotropic OSC molecules grown on poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate (PEDOT:PSS) electrodes show a greater degree of molecular ordering than those grown on Au and multiwalled carbon nanotube/PEDOT:PSS electrodes. Gold 185-187 lanosterol synthase Homo sapiens 20-23 32986402-7 2020 All the anisotropic OSC molecules grown on poly(3,4-ethylenedioxythiophene)-polystyrene sulfonate (PEDOT:PSS) electrodes show a greater degree of molecular ordering than those grown on Au and multiwalled carbon nanotube/PEDOT:PSS electrodes. Carbon 204-210 lanosterol synthase Homo sapiens 20-23 34029588-7 2021 Following this observation, a proteomic screen of the viperin interactome identified several cholesterol biosynthetic enzymes among the top hits, including lanosterol synthase (LS) and squalene monooxygenase (MS), which are enzymes that catalyze key steps in establishing the sterol carbon skeleton. Cholesterol 93-104 lanosterol synthase Homo sapiens 156-175 34029588-7 2021 Following this observation, a proteomic screen of the viperin interactome identified several cholesterol biosynthetic enzymes among the top hits, including lanosterol synthase (LS) and squalene monooxygenase (MS), which are enzymes that catalyze key steps in establishing the sterol carbon skeleton. Carbon 283-289 lanosterol synthase Homo sapiens 156-175 33636107-0 2021 Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation. 24,25-epoxysterol 41-58 lanosterol synthase Homo sapiens 14-33 33636107-5 2021 Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation. cholesterol alpha-oxide 28-44 lanosterol synthase Homo sapiens 110-129 33636107-5 2021 Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation. cholesterol alpha-oxide 28-44 lanosterol synthase Homo sapiens 131-134 33636107-5 2021 Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation. 24,25-epoxycholesterol 157-179 lanosterol synthase Homo sapiens 110-129 33636107-5 2021 Increasing flux through the epoxycholesterol shunt using genetic manipulation or small-molecule inhibition of lanosterol synthase (LSS) increased endogenous 24,25-epoxycholesterol levels and OPC differentiation. 24,25-epoxycholesterol 157-179 lanosterol synthase Homo sapiens 131-134 33636107-7 2021 This work highlights epoxycholesterol shunt usage, controlled by inhibitors of LSS, as a target to promote oligodendrocyte formation. cholesterol alpha-oxide 21-37 lanosterol synthase Homo sapiens 79-82 30116630-6 2018 Results: In lens epithelial cells (LECs), LSS expression in LECs increased with opaque degree C II, while it decreased with opaque degree C IV and C V. While in the cortex of age-related cortical cataract (ARCC), LSS expression was negatively related to opaque degree, while lanosterol level was positively correlated to opaque degree. Lanosterol 275-285 lanosterol synthase Homo sapiens 42-45 32629436-3 2020 In line with these findings, OSC and Col1A1 protein expression was also detected in BM-MSCs on the CS:Gel scaffolds at day 14 of osteogenic differentiation. Cesium 99-101 lanosterol synthase Homo sapiens 29-32 32554062-3 2020 OS carboxylate (OSC), the active form of OS, is formed by the action of endogenous esterase, which targets NA and is shown to significantly reduce influenza-related deaths. oseltamivir carboxylate 0-14 lanosterol synthase Homo sapiens 16-19 32235572-6 2020 Expression of FDPS and OSC, enzymes involved in cholesterol synthesis, are decreased both in drug-resistant cells and upon TRAP1 silencing, whereas the expression of LDL receptor, the main mediator of extracellular cholesterol uptake, is increased. Cholesterol 48-59 lanosterol synthase Homo sapiens 23-26 31760884-6 2020 Regression analysis of BP values with genetic polymorphisms, highlighted an association with a missense variant of LSS (lanosterol synthase, rs2254524), a gene coding for an enzyme involved in endogenous ouabain synthesis. Ouabain 204-211 lanosterol synthase Homo sapiens 120-139 30723320-0 2019 Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome. Cholesterol 82-93 lanosterol synthase Homo sapiens 37-56 30723320-0 2019 Biallelic pathogenic variants in the lanosterol synthase gene LSS involved in the cholesterol biosynthesis cause alopecia with intellectual disability, a rare recessive neuroectodermal syndrome. Cholesterol 82-93 lanosterol synthase Homo sapiens 62-65 30723320-11 2019 CONCLUSION: In the cholesterol biosynthesis pathway, lanosterol synthase leads to the cyclization of (S)-2,3-oxidosqualene into lanosterol. Cholesterol 19-30 lanosterol synthase Homo sapiens 53-72 30723320-11 2019 CONCLUSION: In the cholesterol biosynthesis pathway, lanosterol synthase leads to the cyclization of (S)-2,3-oxidosqualene into lanosterol. 2,3-oxidosqualene 101-122 lanosterol synthase Homo sapiens 53-72 30660405-2 2019 We sought to examine the relationship among EO levels, genetic variants in lanosterol synthase (LSS; an enzyme that catalyzes synthesis of cholesterol, a precursor of EO), and both AKI and chronic kidney injury. Cholesterol 139-150 lanosterol synthase Homo sapiens 75-94 30660405-2 2019 We sought to examine the relationship among EO levels, genetic variants in lanosterol synthase (LSS; an enzyme that catalyzes synthesis of cholesterol, a precursor of EO), and both AKI and chronic kidney injury. Cholesterol 139-150 lanosterol synthase Homo sapiens 96-99 30660405-11 2019 LIMITATIONS: These associations do not necessarily represent causal relationships; LSS rs2254524 variants may have effects on other steroid hormones. Steroids 132-139 lanosterol synthase Homo sapiens 83-86 30740816-4 2019 The ability of Os and Os-C to induce reactive oxygen species (ROS) and to protect against 2,2"-azobis(2-amidinopropane) dihydrochloride-induced oxidative damage in both cell populations was evaluated using 2",7"-dichlorofluorescin diacetate (DCFH-DA). Reactive Oxygen Species 37-60 lanosterol synthase Homo sapiens 22-26 30740816-4 2019 The ability of Os and Os-C to induce reactive oxygen species (ROS) and to protect against 2,2"-azobis(2-amidinopropane) dihydrochloride-induced oxidative damage in both cell populations was evaluated using 2",7"-dichlorofluorescin diacetate (DCFH-DA). Reactive Oxygen Species 62-65 lanosterol synthase Homo sapiens 22-26 30740816-4 2019 The ability of Os and Os-C to induce reactive oxygen species (ROS) and to protect against 2,2"-azobis(2-amidinopropane) dihydrochloride-induced oxidative damage in both cell populations was evaluated using 2",7"-dichlorofluorescin diacetate (DCFH-DA). 2,2'-azobis(2-amidinopropane) 90-135 lanosterol synthase Homo sapiens 22-26 30740816-8 2019 Os-C caused MN and PMN leukocyte activation associated with ROS formation and was unable to penetrate cell membranes, indicating extracellular membrane interactions. Reactive Oxygen Species 60-63 lanosterol synthase Homo sapiens 0-4 30740816-11 2019 In contrast, the ability of Os-C to activate MN and PMN cells implies that this peptide should be further evaluated as an AMP, which, in addition to its ability to eradicate infection, can further enhance host immunity. Adenosine Monophosphate 122-125 lanosterol synthase Homo sapiens 28-32 30740816-12 2019 These novel characteristics of Os and Os-C indicate that these AMPs as peptides can be further developed for specific applications. Adenylyl sulfate 63-67 lanosterol synthase Homo sapiens 38-42 32101538-6 2020 We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency. oxidosqualene 97-118 lanosterol synthase Homo sapiens 35-38 32101538-6 2020 We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency. oxidosqualene 97-118 lanosterol synthase Homo sapiens 212-215 32101538-6 2020 We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency. Lanosterol 119-129 lanosterol synthase Homo sapiens 35-38 32101538-6 2020 We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency. Lanosterol 119-129 lanosterol synthase Homo sapiens 212-215 30084659-3 2018 Through RNA interference library screening, we identified lanosterol synthase (LSS), a component of the cholesterol biosynthetic pathway, as a novel regulator of RV replication in primary normal human bronchial epithelial cells. Cholesterol 104-115 lanosterol synthase Homo sapiens 58-77 30084659-3 2018 Through RNA interference library screening, we identified lanosterol synthase (LSS), a component of the cholesterol biosynthetic pathway, as a novel regulator of RV replication in primary normal human bronchial epithelial cells. Cholesterol 104-115 lanosterol synthase Homo sapiens 79-82 30084659-8 2018 We showed that LSS inhibition led to an induction of 24(S),25 epoxycholesterol, an important regulator of the sterol pathway. cholesterol alpha-oxide 62-78 lanosterol synthase Homo sapiens 15-18 30084659-8 2018 We showed that LSS inhibition led to an induction of 24(S),25 epoxycholesterol, an important regulator of the sterol pathway. Sterols 72-78 lanosterol synthase Homo sapiens 15-18 30084659-10 2018 We found LSS to be a novel regulator of RV replication and innate antiviral immunity and identified a potential molecular mechanism for this effect, via induction of 24(S),25 epoxycholesterol. cholesterol alpha-oxide 175-191 lanosterol synthase Homo sapiens 9-12 30401459-5 2018 LSS encodes lanosterol synthase (LSS), which is a key enzyme in the cholesterol biosynthetic pathway. Cholesterol 68-79 lanosterol synthase Homo sapiens 0-3 30401459-5 2018 LSS encodes lanosterol synthase (LSS), which is a key enzyme in the cholesterol biosynthetic pathway. Cholesterol 68-79 lanosterol synthase Homo sapiens 12-31 30401459-5 2018 LSS encodes lanosterol synthase (LSS), which is a key enzyme in the cholesterol biosynthetic pathway. Cholesterol 68-79 lanosterol synthase Homo sapiens 33-36 30401459-12 2018 The identification of LSS as causal gene for autosomal-recessive HS highlights the importance of the cholesterol pathway in hair follicle biology and may facilitate novel therapeutic approaches for hair loss disorders in general. Cholesterol 101-112 lanosterol synthase Homo sapiens 22-25 28462697-1 2017 BACKGROUND: Lanosterol synthase (Oxidosqualene cyclase) is an enzyme, which plays a central role in cholesterol and sterols biosynthesis. Cholesterol 100-111 lanosterol synthase Homo sapiens 12-31 28462697-1 2017 BACKGROUND: Lanosterol synthase (Oxidosqualene cyclase) is an enzyme, which plays a central role in cholesterol and sterols biosynthesis. Sterols 116-123 lanosterol synthase Homo sapiens 12-31 28462697-2 2017 Lanosterol synthase drugs are used to lower the level of cholesterol in the blood and treat wide variety of diseases like atherosclerosis, coronary heart diseases etc. Cholesterol 57-68 lanosterol synthase Homo sapiens 0-19 26667413-0 2016 Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake. Sodium 96-102 lanosterol synthase Homo sapiens 0-19 26667413-2 2016 Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocortical cells. Cholesterol 56-67 lanosterol synthase Homo sapiens 13-32 26667413-6 2016 Lanosterol synthase gene polymorphisms influence both the salt sensitivity of BP and changes in circulating EO in response to a low salt diet. Salts 58-62 lanosterol synthase Homo sapiens 0-19 26667413-6 2016 Lanosterol synthase gene polymorphisms influence both the salt sensitivity of BP and changes in circulating EO in response to a low salt diet. Salts 132-136 lanosterol synthase Homo sapiens 0-19 22933236-1 2012 Lanosterol synthase catalyzes the polycyclization reaction of (3S)-2,3-oxidosqualene (1) into tetracyclic lanosterol 2 by folding 1 in a chair-boat-chair-chair conformation. (S)-2,3-Epoxysqualene 62-84 lanosterol synthase Homo sapiens 0-19 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. Cholesterol 65-76 lanosterol synthase Homo sapiens 9-34 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. Cholesterol 65-76 lanosterol synthase Homo sapiens 36-39 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. 2,3-monoepoxysqualene 137-158 lanosterol synthase Homo sapiens 9-34 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. 2,3-monoepoxysqualene 137-158 lanosterol synthase Homo sapiens 36-39 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. Lanosterol 162-172 lanosterol synthase Homo sapiens 9-34 25855471-1 2015 PURPOSE: 2,3-Oxidosqualene cyclase (OSC), an important enzyme of cholesterol biosynthesis, catalyzes the highly selective cyclization of 2,3-monoepoxysqualene to lanosterol. Lanosterol 162-172 lanosterol synthase Homo sapiens 36-39 25855471-11 2015 Moreover, over-expression of OSC could attenuate IH-induced cellular triglyceride accumulation. Ile-His 49-51 lanosterol synthase Homo sapiens 29-32 25855471-11 2015 Moreover, over-expression of OSC could attenuate IH-induced cellular triglyceride accumulation. Triglycerides 69-81 lanosterol synthase Homo sapiens 29-32 25855471-12 2015 CONCLUSIONS: These findings suggest that OSC are involved in IH-induced hepatic cell injury. Ile-His 61-63 lanosterol synthase Homo sapiens 41-44 25962741-2 2015 Human oxidosqualene cyclase (hOSC) is a membrane-bound triterpene cyclase that catalyzes the formation of the tetracyclic steroidal backbone, a key step in cholesterol biosynthesis. Cholesterol 156-167 lanosterol synthase Homo sapiens 29-33 26698156-5 2016 Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover. Cholesterol 39-50 lanosterol synthase Homo sapiens 120-139 26698156-5 2016 Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover. 24,25-epoxycholesterol 167-189 lanosterol synthase Homo sapiens 120-139 26200341-6 2015 It is synthesized by lanosterol synthase (LSS) in a key cyclization reaction of a cholesterol synthesis pathway. Cholesterol 82-93 lanosterol synthase Homo sapiens 21-40 26200341-6 2015 It is synthesized by lanosterol synthase (LSS) in a key cyclization reaction of a cholesterol synthesis pathway. Cholesterol 82-93 lanosterol synthase Homo sapiens 42-45 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. aminopropylindenes 12-30 lanosterol synthase Homo sapiens 97-121 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. aminopropylindenes 12-30 lanosterol synthase Homo sapiens 123-126 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. 2,3-oxidosqualen 152-168 lanosterol synthase Homo sapiens 97-121 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. 2,3-oxidosqualen 152-168 lanosterol synthase Homo sapiens 123-126 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. Lanosterol 172-182 lanosterol synthase Homo sapiens 97-121 23583910-1 2013 A series of aminopropylindenes, designed as mimics of a cationic high energy intermediate in the oxidosqualene cyclase(1) (OSC)-mediated cyclization of 2,3-oxidosqualen to lanosterol was prepared from Grundmann"s ketone. Grundmann's ketone 201-219 lanosterol synthase Homo sapiens 97-121 23130825-1 2012 Oxidosqualene-lanosterol cyclase (OSC) is a key enzyme in the biosynthesis of cholesterol. Cholesterol 78-89 lanosterol synthase Homo sapiens 0-32 23130825-1 2012 Oxidosqualene-lanosterol cyclase (OSC) is a key enzyme in the biosynthesis of cholesterol. Cholesterol 78-89 lanosterol synthase Homo sapiens 34-37 23130825-5 2012 We show that the product specificity of OSC at the hydride/methyl-shifting stage is unlikely to be achieved by the stabilization of the cationic intermediates, as the precursor of lanosterol is in fact not the most stable cationic intermediate for wild-type OSC. Lanosterol 180-190 lanosterol synthase Homo sapiens 40-43 22933236-1 2012 Lanosterol synthase catalyzes the polycyclization reaction of (3S)-2,3-oxidosqualene (1) into tetracyclic lanosterol 2 by folding 1 in a chair-boat-chair-chair conformation. Lanosterol 106-116 lanosterol synthase Homo sapiens 0-19 18480904-4 2008 The experimental results allow for an instructive comparison with the enzymic processes, particularly those of the cyclases in steroid biosynthesis (i.e. lanosterol synthase). Steroids 127-134 lanosterol synthase Homo sapiens 154-173 19522517-5 2009 Each ruthenium (osmium) atom is covalently bonded to four C(2) pairs with Ru-C (Os-C) distances of 220-222 pm. Ruthenium 5-14 lanosterol synthase Homo sapiens 80-84 19522517-5 2009 Each ruthenium (osmium) atom is covalently bonded to four C(2) pairs with Ru-C (Os-C) distances of 220-222 pm. Osmium 16-22 lanosterol synthase Homo sapiens 80-84 22137785-2 2012 All of these inhibitors were revealed to have activities comparable or superior to that of LDAO, a known OSC inhibitor. dodecyldimethylamine oxide 91-95 lanosterol synthase Homo sapiens 105-108 17925399-0 2007 Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression. Cholesterol 37-48 lanosterol synthase Homo sapiens 81-100 18324586-6 2008 Solely the treatment of LSS with epidural steroids, which is recommended by most of the authors, has been evaluated by several randomised controlled studies with a high level of evidence. Steroids 42-50 lanosterol synthase Homo sapiens 24-27 17925399-3 2007 Because of the crucial role that lanosterol synthase plays in cholesterol biosynthesis, there is great interest in the identification of drugs that target this enzyme for anticholesteremic purposes. Cholesterol 62-73 lanosterol synthase Homo sapiens 33-52 15951028-5 2005 Through this dual mechanism, OSC inhibition decreases plasma levels of low-density lipoprotein (LDL)-cholesterol and prevents cholesterol deposition within macrophages. Cholesterol 101-112 lanosterol synthase Homo sapiens 29-32 16435854-0 2006 A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants. isomalabaricane 24-39 lanosterol synthase Homo sapiens 59-78 16435854-0 2006 A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants. triterpenoids 40-53 lanosterol synthase Homo sapiens 59-78 16435854-2 2006 Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. oxidosqualene 84-97 lanosterol synthase Homo sapiens 6-25 16320765-0 2005 Revised structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929. fki-0929 105-113 lanosterol synthase Homo sapiens 53-72 17444640-3 2007 These are mono- and bis-Pt(PBut3) adducts of 9 formed by the addition of a Pt(PBut3) group to the Os-Os bond in 11 and the Os-Os bond and Os-C bond to the sigma-bonded phenyl group in 12. Platinum 23-26 lanosterol synthase Homo sapiens 138-142 17444640-3 2007 These are mono- and bis-Pt(PBut3) adducts of 9 formed by the addition of a Pt(PBut3) group to the Os-Os bond in 11 and the Os-Os bond and Os-C bond to the sigma-bonded phenyl group in 12. Osmium 98-100 lanosterol synthase Homo sapiens 138-142 17444640-3 2007 These are mono- and bis-Pt(PBut3) adducts of 9 formed by the addition of a Pt(PBut3) group to the Os-Os bond in 11 and the Os-Os bond and Os-C bond to the sigma-bonded phenyl group in 12. Osmium 101-103 lanosterol synthase Homo sapiens 138-142 17444640-3 2007 These are mono- and bis-Pt(PBut3) adducts of 9 formed by the addition of a Pt(PBut3) group to the Os-Os bond in 11 and the Os-Os bond and Os-C bond to the sigma-bonded phenyl group in 12. Osmium 101-103 lanosterol synthase Homo sapiens 138-142 17444640-3 2007 These are mono- and bis-Pt(PBut3) adducts of 9 formed by the addition of a Pt(PBut3) group to the Os-Os bond in 11 and the Os-Os bond and Os-C bond to the sigma-bonded phenyl group in 12. Osmium 101-103 lanosterol synthase Homo sapiens 138-142 17145976-11 2007 Wethers fed the Osc diet tended (P = 0.06) to have a greater PDV uptake of urea N than did those fed the Medium diet, but there was no difference between the Osc and Medium diets (P = 0.72) in hepatic urea N release. urea n 75-81 lanosterol synthase Homo sapiens 16-19 15951028-2 2005 OSC catalyzes the cyclization of the linear 2,3-monoepoxysqualene to lanosterol, the initial four-ringed sterol intermediate in the cholesterol biosynthetic pathway. 2,3-monoepoxysqualene 44-65 lanosterol synthase Homo sapiens 0-3 15951028-2 2005 OSC catalyzes the cyclization of the linear 2,3-monoepoxysqualene to lanosterol, the initial four-ringed sterol intermediate in the cholesterol biosynthetic pathway. Lanosterol 69-79 lanosterol synthase Homo sapiens 0-3 15951028-2 2005 OSC catalyzes the cyclization of the linear 2,3-monoepoxysqualene to lanosterol, the initial four-ringed sterol intermediate in the cholesterol biosynthetic pathway. Sterols 73-79 lanosterol synthase Homo sapiens 0-3 15951028-5 2005 Through this dual mechanism, OSC inhibition decreases plasma levels of low-density lipoprotein (LDL)-cholesterol and prevents cholesterol deposition within macrophages. Cholesterol 126-137 lanosterol synthase Homo sapiens 29-32 15951028-2 2005 OSC catalyzes the cyclization of the linear 2,3-monoepoxysqualene to lanosterol, the initial four-ringed sterol intermediate in the cholesterol biosynthetic pathway. Cholesterol 132-143 lanosterol synthase Homo sapiens 0-3 15951028-3 2005 OSC also catalyzes the formation of 24(S),25-epoxycholesterol, a ligand activator of the liver X receptor. 24,25-epoxycholesterol 36-61 lanosterol synthase Homo sapiens 0-3 15951028-4 2005 Inhibition of OSC reduces cholesterol biosynthesis and selectively enhances 24(S),25-epoxycholesterol synthesis. Cholesterol 26-37 lanosterol synthase Homo sapiens 14-17 15951028-4 2005 Inhibition of OSC reduces cholesterol biosynthesis and selectively enhances 24(S),25-epoxycholesterol synthesis. -epoxycholesterol 84-101 lanosterol synthase Homo sapiens 14-17 15951028-6 2005 The recent crystallization of OSC identifies the mechanism of action for this complex enzyme, setting the stage for the design of OSC inhibitors with improved pharmacological properties for cholesterol lowering and treatment of atherosclerosis. Cholesterol 190-201 lanosterol synthase Homo sapiens 30-33 15951028-6 2005 The recent crystallization of OSC identifies the mechanism of action for this complex enzyme, setting the stage for the design of OSC inhibitors with improved pharmacological properties for cholesterol lowering and treatment of atherosclerosis. Cholesterol 190-201 lanosterol synthase Homo sapiens 130-133 16833861-0 2005 Infrared spectra and structures of the OSc(N2), OScNN, and OScNN+ complexes in solid argon. Argon 85-90 lanosterol synthase Homo sapiens 39-45 16833861-1 2005 Scandium monoxide-dinitrogen complexes-OSc(N2), OScNN, and OScNN+-have been prepared by the reactions of laser-evaporated scandium monoxide with N2 or scandium atoms with N2O in solid argon. scandium monoxide 0-17 lanosterol synthase Homo sapiens 39-45 16833861-1 2005 Scandium monoxide-dinitrogen complexes-OSc(N2), OScNN, and OScNN+-have been prepared by the reactions of laser-evaporated scandium monoxide with N2 or scandium atoms with N2O in solid argon. Nitrogen 18-28 lanosterol synthase Homo sapiens 39-45 16833861-1 2005 Scandium monoxide-dinitrogen complexes-OSc(N2), OScNN, and OScNN+-have been prepared by the reactions of laser-evaporated scandium monoxide with N2 or scandium atoms with N2O in solid argon. Nitrous Oxide 171-174 lanosterol synthase Homo sapiens 39-45 16833861-2 2005 The ground-state scandium monoxide molecule reacted with N2 to form the side-bonded OSc(N2) complex spontaneously on annealing. scandium monoxide 17-34 lanosterol synthase Homo sapiens 84-90 16833861-2 2005 The ground-state scandium monoxide molecule reacted with N2 to form the side-bonded OSc(N2) complex spontaneously on annealing. Nitrogen 57-59 lanosterol synthase Homo sapiens 84-90 16833861-4 2005 Both the OSc(N2) and OScNN complexes in solid argon can be assigned to have 2A" " electronic ground state with Cs symmetry arising from the 2Delta first excited-state ScO. Argon 46-51 lanosterol synthase Homo sapiens 9-15 16833861-4 2005 Both the OSc(N2) and OScNN complexes in solid argon can be assigned to have 2A" " electronic ground state with Cs symmetry arising from the 2Delta first excited-state ScO. Cesium 111-113 lanosterol synthase Homo sapiens 9-15 15684488-1 2005 Ethanol extracts of lyophilized vegetables were tested for inhibition of human lanosterol synthase (hOSC) in order to find the compounds to suppress cholesterol biosynthesis. Ethanol 0-7 lanosterol synthase Homo sapiens 100-104 12852766-1 2003 New orally active non-terpenoic inhibitors of human 2,3-oxidosqualene cyclase (hOSC) are reported. terpenoic 22-31 lanosterol synthase Homo sapiens 79-83 15582431-0 2005 Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase. digalactosyldiacylglycerol 13-41 lanosterol synthase Homo sapiens 91-110 15582431-2 2005 The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. dgdg 27-31 lanosterol synthase Homo sapiens 69-88 15582431-2 2005 The inhibitory activity of DGDG, MGDG and related compounds on human lanosterol synthase was evaluated as anti-hyperlipemic activity. mgdg 33-37 lanosterol synthase Homo sapiens 69-88 15525992-0 2004 Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Steroids 13-20 lanosterol synthase Homo sapiens 68-89 15525992-1 2004 In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase (OSC; lanosterol synthase). Steroids 41-48 lanosterol synthase Homo sapiens 105-126 15525992-1 2004 In higher organisms the formation of the steroid scaffold is catalysed exclusively by the membrane-bound oxidosqualene cyclase (OSC; lanosterol synthase). Steroids 41-48 lanosterol synthase Homo sapiens 128-131 15525992-2 2004 In a highly selective cyclization reaction OSC forms lanosterol with seven chiral centres starting from the linear substrate 2,3-oxidosqualene. Lanosterol 53-63 lanosterol synthase Homo sapiens 43-46 15525992-2 2004 In a highly selective cyclization reaction OSC forms lanosterol with seven chiral centres starting from the linear substrate 2,3-oxidosqualene. 2,3-oxidosqualene 125-142 lanosterol synthase Homo sapiens 43-46 15525992-5 2004 Because of the decisive role of OSC in cholesterol biosynthesis it represents a target for the discovery of novel anticholesteraemic drugs that could complement the widely used statins. Cholesterol 39-50 lanosterol synthase Homo sapiens 32-35 15525992-6 2004 Here we present two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors. Cholesterol 123-134 lanosterol synthase Homo sapiens 69-72 15525992-6 2004 Here we present two crystal structures of the human membrane protein OSC: the target protein with an inhibitor that showed cholesterol lowering in vivo opens the way for the structure-based design of new OSC inhibitors. Cholesterol 123-134 lanosterol synthase Homo sapiens 204-207 15580956-0 2004 Epohelmins A and B, novel lanosterol synthase inhibitors from a fungal strain FKI-0929. fki-0929 78-86 lanosterol synthase Homo sapiens 26-45 15580956-1 2004 From a fungal strain FKI-0929, two compounds designated epohelmins A and B, were isolated as new natural products with inhibitory activity against recombinant human lanosterol synthase. fki-0929 21-29 lanosterol synthase Homo sapiens 165-184 14766201-1 2004 The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol precursor of cholesterol in mammals. Lanosterol 99-109 lanosterol synthase Homo sapiens 67-70 14766201-1 2004 The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol precursor of cholesterol in mammals. Sterols 103-109 lanosterol synthase Homo sapiens 67-70 14766201-1 2004 The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol precursor of cholesterol in mammals. Cholesterol 140-151 lanosterol synthase Homo sapiens 67-70 14766201-4 2004 The obtained IC(50) for the reference inhibitor Ro 48-8071 is nearly identical for the recombinant hOSC compared to OSC from human liver microsomes. Ro 48-8071 48-58 lanosterol synthase Homo sapiens 99-103 14766201-4 2004 The obtained IC(50) for the reference inhibitor Ro 48-8071 is nearly identical for the recombinant hOSC compared to OSC from human liver microsomes. Ro 48-8071 48-58 lanosterol synthase Homo sapiens 100-103 14512442-0 2003 Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation. Oxysterols 26-35 lanosterol synthase Homo sapiens 94-130 14512442-0 2003 Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation. 25-epoxycholesterol 42-61 lanosterol synthase Homo sapiens 94-130 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. 25-epoxycholesterol 30-49 lanosterol synthase Homo sapiens 115-151 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. 25-epoxycholesterol 30-49 lanosterol synthase Homo sapiens 153-156 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. Cholesterol 38-49 lanosterol synthase Homo sapiens 115-151 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. Cholesterol 38-49 lanosterol synthase Homo sapiens 153-156 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. Oxysterols 244-253 lanosterol synthase Homo sapiens 115-151 14512442-5 2003 Macrophage synthesis of 24(S),25-epoxycholesterol, a potent LXR ligand, increased 60-fold by partial inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), a microsomal enzyme in both the cholesterol biosynthetic pathway and the alternative oxysterol synthetic pathway. Oxysterols 244-253 lanosterol synthase Homo sapiens 153-156 14512442-11 2003 Furthermore, OSC inhibition significantly upregulated ABCA1 and ABCG1 expression, which led to enhanced macrophage cholesterol efflux, an effect mediated through LXR activation. Cholesterol 115-126 lanosterol synthase Homo sapiens 13-16 9162756-0 1997 Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. ro 48-8.071 0-11 lanosterol synthase Homo sapiens 19-55 10783007-2 2000 5.4.99.-), an enzyme of bacterial membranes catalyzing the formation of pentacyclic sterol-like triterpenes, was studied by using different classes of compounds originally developed as inhibitors of oxidosqualene cyclase (OSC) (E.C. Triterpenes 96-107 lanosterol synthase Homo sapiens 199-220 10783007-4 2000 The mechanism of cyclization of squalene by SHC, beginning with a protonation of the 2,3 double bond by an acidic residue of the enzyme, followed by a series of electrophilic additions of the carbocationic intermediates to the double bonds, is similar to the mechanism of cyclization of 2,3-oxidosqualene by OSC. Squalene 32-40 lanosterol synthase Homo sapiens 308-311 10598817-5 1999 We considered LS an excellent candidate HPE gene because of the requirement for cholesterol modification of the Sonic Hedgehog protein for the correct patterning activity of this HPE-associated protein. Cholesterol 80-91 lanosterol synthase Homo sapiens 14-16 9795371-17 1998 Furthermore, biochemical markers indicating bone loss (ICTP) and increased bone turnover (PTH, OSC) correlated positively with IGFBP-1 and IGFBP-4 but negatively with IGF-I, IGFBP-3 and IGFBP-5, while the opposite was observed with bone formation markers (PICP, B-ALP) and vitamin D3 metabolites. Cholecalciferol 273-283 lanosterol synthase Homo sapiens 95-98 9162756-3 1997 Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop. Lanosterol 53-63 lanosterol synthase Homo sapiens 22-25 9162756-11 1997 Altogether these findings clearly differentiate the OSC inhibitor Ro 48-8.071 from simvastatin, and support the view that OSC is a distinct key component in the regulation of the cholesterol synthesis pathway. ro 48-8.071 66-77 lanosterol synthase Homo sapiens 52-55 9162756-11 1997 Altogether these findings clearly differentiate the OSC inhibitor Ro 48-8.071 from simvastatin, and support the view that OSC is a distinct key component in the regulation of the cholesterol synthesis pathway. Cholesterol 179-190 lanosterol synthase Homo sapiens 52-55 9162756-11 1997 Altogether these findings clearly differentiate the OSC inhibitor Ro 48-8.071 from simvastatin, and support the view that OSC is a distinct key component in the regulation of the cholesterol synthesis pathway. Cholesterol 179-190 lanosterol synthase Homo sapiens 122-125 7639730-1 1995 Lanosterol synthase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7] catalyzes the cyclization of (S)-2,3-oxidosqualene to lanosterol in the reaction that forms the sterol nucleus. Lanosterol 62-72 lanosterol synthase Homo sapiens 0-19 8691425-5 1996 The resulting structure-activity relationships seem to validate the mechanism of action of these inhibitors as analogs of a pro-C-8 high-energy intermediate and delineate the minimal requirements for the design of efficient isoquinoline-based, or simplified, OSC inhibitors. isoquinoline 224-236 lanosterol synthase Homo sapiens 259-262 7639730-1 1995 Lanosterol synthase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7] catalyzes the cyclization of (S)-2,3-oxidosqualene to lanosterol in the reaction that forms the sterol nucleus. 2,3-oxidosqualene 125-146 lanosterol synthase Homo sapiens 0-19 7639730-1 1995 Lanosterol synthase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7] catalyzes the cyclization of (S)-2,3-oxidosqualene to lanosterol in the reaction that forms the sterol nucleus. Lanosterol 150-160 lanosterol synthase Homo sapiens 0-19 34726809-10 2021 Osteoblasts reduced cholesterol synthesis in chondrocytes by reducing the expression of a series of synthetases, including Fdft1, Sqle, Lss, Cyp51, Msmo1, Nsdhl, Sc5d, Dhcr24 and Dhcr7. Cholesterol 20-31 lanosterol synthase Homo sapiens 136-139 1445330-0 1992 Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase. -dioxidosqualene 43-59 lanosterol synthase Homo sapiens 77-109 1445330-1 1992 Kinetic studies on the cyclization of 2,3(S)-oxido and 2,3(S):22(S),23-dioxido[14C]squalene catalyzed by liver oxidosqualene-lanosterol cyclase revealed a specificity (in terms of V/Km) of the enzyme for the diepoxide. 2,3(s)-oxido 38-50 lanosterol synthase Homo sapiens 111-143 1445330-1 1992 Kinetic studies on the cyclization of 2,3(S)-oxido and 2,3(S):22(S),23-dioxido[14C]squalene catalyzed by liver oxidosqualene-lanosterol cyclase revealed a specificity (in terms of V/Km) of the enzyme for the diepoxide. dioxido[14c]squalene 71-91 lanosterol synthase Homo sapiens 111-143 1445330-1 1992 Kinetic studies on the cyclization of 2,3(S)-oxido and 2,3(S):22(S),23-dioxido[14C]squalene catalyzed by liver oxidosqualene-lanosterol cyclase revealed a specificity (in terms of V/Km) of the enzyme for the diepoxide. diepoxide 208-217 lanosterol synthase Homo sapiens 111-143 34751594-2 2022 Minimally invasive lumbar decompression (commonly known as the mild Procedure) and epidural steroid injections are both common treatment options for lumbar spinal stenosis (commonly referred to as LSS), a condition that causes chronic lower back pain in older adults. Steroids 92-99 lanosterol synthase Homo sapiens 197-200 34751594-3 2022 To determine how to best treat LSS patients, healthcare professionals use a guide to help with the decision-making process (called an algorithm) to pass through non-medical to more invasive therapies that often includes one or more epidural steroid injections. Steroids 241-248 lanosterol synthase Homo sapiens 31-34 34440098-4 2021 This work is aimed at systematization and bioinformatic analysis of the available interactomics data on seventeen enzymes in the cholesterol pathway, encoded by HMGCR, MVK, PMVK, MVD, FDPS, FDFT1, SQLE, LSS, DHCR24, CYP51A1, TM7SF2, MSMO1, NSDHL, HSD17B7, EBP, SC5D, DHCR7 genes. Cholesterol 129-140 lanosterol synthase Homo sapiens 203-206 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Cholesterol 62-73 lanosterol synthase Homo sapiens 0-3 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. 2,3-oxidosqualene 109-130 lanosterol synthase Homo sapiens 12-31 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Cholesterol 62-73 lanosterol synthase Homo sapiens 12-31 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. 2,3-oxidosqualene 109-130 lanosterol synthase Homo sapiens 33-36 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Lanosterol 134-144 lanosterol synthase Homo sapiens 0-3 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Cholesterol 62-73 lanosterol synthase Homo sapiens 33-36 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Lanosterol 134-144 lanosterol synthase Homo sapiens 12-31 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. 2,3-oxidosqualene 109-130 lanosterol synthase Homo sapiens 0-3 35413293-4 2022 LSS encodes lanosterol synthase (LSS), which functions in the cholesterol biosynthesis pathway by converting (S)-2,3-oxidosqualene to lanosterol. Lanosterol 134-144 lanosterol synthase Homo sapiens 33-36 35197069-13 2022 Analysis with qRT-PCR suggested that combination treatment decreased cholesterol biosynthesis genes DHCR24 (24-dehydrocholesterol reductase) and LSS (lanosterol synthase) but increased genes involved in glycolysis and TCA cycle. Cholesterol 69-80 lanosterol synthase Homo sapiens 150-169 35413293-8 2022 Remarkably decreased lanosterol levels were found in vitro in three LSS variants, LSS-DeltaN80, p.Ile342Ser, and p.Gly508Trp, suggesting loss of enzymatic activity. Lanosterol 21-31 lanosterol synthase Homo sapiens 68-71 35413293-8 2022 Remarkably decreased lanosterol levels were found in vitro in three LSS variants, LSS-DeltaN80, p.Ile342Ser, and p.Gly508Trp, suggesting loss of enzymatic activity. Lanosterol 21-31 lanosterol synthase Homo sapiens 82-85 35413293-10 2022 Taken together, our findings indicate LSS as a causative gene for PPKCA2, which emphasizes the importance of cholesterol synthesis pathway in human skin cornification. Cholesterol 109-120 lanosterol synthase Homo sapiens 38-41