PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33453277-0	2021	Hydrogen sulfide is synthesized endogenously in both retinal artery and retina mostly via CSE.	Hydrogen Sulfide	0-16	cystathionine gamma-lyase	Bos taurus	90-93
34769192-0	2021	Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-beta1: Induction of Cystathionine gamma-Lyase and Cystathionine beta-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways.	reactive sulfur species	13-36	cystathionine gamma-lyase	Bos taurus	118-143
4034673-6	1985	The overall reaction is explained by the action of heat stable cystathionine gamma-lyase and beta-synthase which produce alpha-ketobutyrate and pyruvate used for the transamination of the remaining cystathionine to the monoketoacid.	2-oxobutanoate	121-139	cystathionine gamma-lyase	Bos taurus	63-88
4034673-6	1985	The overall reaction is explained by the action of heat stable cystathionine gamma-lyase and beta-synthase which produce alpha-ketobutyrate and pyruvate used for the transamination of the remaining cystathionine to the monoketoacid.	Pyruvic Acid	144-152	cystathionine gamma-lyase	Bos taurus	63-88
4034673-6	1985	The overall reaction is explained by the action of heat stable cystathionine gamma-lyase and beta-synthase which produce alpha-ketobutyrate and pyruvate used for the transamination of the remaining cystathionine to the monoketoacid.	monoketoacid	219-231	cystathionine gamma-lyase	Bos taurus	63-88
33453277-3	2021	The enzymes that mediate H2S synthesis are 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Deuterium	25-28	cystathionine gamma-lyase	Bos taurus	127-152
33453277-3	2021	The enzymes that mediate H2S synthesis are 3-mercaptopyruvate sulfurtransferase (3-MST), cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Deuterium	25-28	cystathionine gamma-lyase	Bos taurus	154-157
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	reactive persulfides	30-50	cystathionine gamma-lyase	Bos taurus	80-105
32842680-0	2020	Transcriptional Induction of Cystathionine gamma-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells.	Sulfur	67-73	cystathionine gamma-lyase	Bos taurus	29-54
32842680-0	2020	Transcriptional Induction of Cystathionine gamma-Lyase, a Reactive Sulfur-Producing Enzyme, by Copper Diethyldithiocarbamate in Cultured Vascular Endothelial Cells.	Cupric diethyldithiocarbamate	95-124	cystathionine gamma-lyase	Bos taurus	29-54
32842680-3	2020	Reactive sulfur species are produced by enzymes, such as cystathionine gamma-lyase (CSE), cystathionine beta-synthase, 3-mercaptopyruvate sulfurtransferase, and cysteinyl-tRNA synthetase.	Sulfur	9-15	cystathionine gamma-lyase	Bos taurus	57-82
32842680-3	2020	Reactive sulfur species are produced by enzymes, such as cystathionine gamma-lyase (CSE), cystathionine beta-synthase, 3-mercaptopyruvate sulfurtransferase, and cysteinyl-tRNA synthetase.	Sulfur	9-15	cystathionine gamma-lyase	Bos taurus	84-87
32842680-8	2020	This transcriptional induction of endothelial CSE required both the diethyldithiocarbamate scaffold and the coordinated copper ion.	Ditiocarb	68-90	cystathionine gamma-lyase	Bos taurus	46-49
32842680-8	2020	This transcriptional induction of endothelial CSE required both the diethyldithiocarbamate scaffold and the coordinated copper ion.	Copper	120-126	cystathionine gamma-lyase	Bos taurus	46-49
32842680-10	2020	The transcription factors NF-kappaB, Sp1, and ATF4 were suggested to act in constitutive CSE expression, although the possibility that they are involved in the CSE induction by Cu10 cannot be excluded.	cu10	177-181	cystathionine gamma-lyase	Bos taurus	160-163
32842680-11	2020	The present study used a copper complex as a molecular probe to reveal that the transcription of CSE is regulated by multiple pathways in vascular endothelial cells, including ERK1/2, p38 MAPK, and HIF-1alpha/HIF-1beta.	Copper	25-31	cystathionine gamma-lyase	Bos taurus	97-100
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Aminooxyacetic Acid	125-145	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Aminooxyacetic Acid	147-150	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	GYY 4137	202-210	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Cysteine	212-222	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Acetylcysteine	227-243	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	Tritium	258-260	cystathionine gamma-lyase	Bos taurus	92-117
29353375-4	2018	A dual inhibitor of the biosynthetic enzymes for H2S, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), amino-oxyacetic acid (AOA; 3 mM) reversed the inhibitory responses caused by GYY 4137, L-cysteine and N-acetylcysteine on K+-evoked [3H]D-aspartate release.	D-Aspartic Acid	261-272	cystathionine gamma-lyase	Bos taurus	92-117
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	reactive persulfides	30-50	cystathionine gamma-lyase	Bos taurus	107-110
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	polysulfide	55-67	cystathionine gamma-lyase	Bos taurus	80-105
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	polysulfide	55-67	cystathionine gamma-lyase	Bos taurus	107-110
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	Cadmium	177-184	cystathionine gamma-lyase	Bos taurus	80-105
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	Cadmium	177-184	cystathionine gamma-lyase	Bos taurus	107-110
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	reactive sulfur species	210-233	cystathionine gamma-lyase	Bos taurus	80-105
28115653-2	2017	The current consensus is that reactive persulfides and polysulfides produced by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are highly nucleophilic and thus cadmium may be captured by these reactive sulfur species.	reactive sulfur species	210-233	cystathionine gamma-lyase	Bos taurus	107-110
28115653-7	2017	The knockdown of CSE and/or cystathionine beta-synthase decreased the levels of reactive sulfur species in the cells and increased the degree of HSP70 induction and cytotoxicity caused by exposure to cadmium.	reactive sulfur species	80-103	cystathionine gamma-lyase	Bos taurus	17-20
28115653-7	2017	The knockdown of CSE and/or cystathionine beta-synthase decreased the levels of reactive sulfur species in the cells and increased the degree of HSP70 induction and cytotoxicity caused by exposure to cadmium.	Cadmium	200-207	cystathionine gamma-lyase	Bos taurus	17-20
28115653-8	2017	Overexpression of CSE diminished cadmium-mediated up-regulation of HSP70 and cytotoxicity.	Cadmium	33-40	cystathionine gamma-lyase	Bos taurus	18-21
27506718-2	2016	The method exploits cystathionine gamma-lyase as an ancillary enzyme capable of transforming cystathionine, produced by cystathionine beta-synthase, into cysteine.	Cysteine	154-162	cystathionine gamma-lyase	Bos taurus	20-45
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Cysteine	31-41	cystathionine gamma-lyase	Bos taurus	319-344
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Cysteine	31-41	cystathionine gamma-lyase	Bos taurus	346-349
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Hydrogen Sulfide	71-74	cystathionine gamma-lyase	Bos taurus	319-344
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Hydrogen Sulfide	71-74	cystathionine gamma-lyase	Bos taurus	346-349
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Dinoprost	116-125	cystathionine gamma-lyase	Bos taurus	319-344
25662313-10	2015	In addition, administration of l-cysteine (1muM-3mM), the precursor of H2S, induced a modest relaxation response in PGF2alpha precontracted retinal arteries, which was significantly decreased in the presence of cystathionine-beta-synthase (CBS) inhibitor, aminooxyacetic acid, but was unmodified in the presence of the cystathionine-gamma-lyase (CSE) inhibitor, dl-propargylglycine or the deendothelization of retinal arteries.	Dinoprost	116-125	cystathionine gamma-lyase	Bos taurus	346-349