PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 8413871-10 1993 Propofol and thiopental showed significantly stronger suppression of MEP, when compared to etomidate (both P < 0.01) and to methohexital (P = 0.01 and 0.05, respectively). Propofol 0-8 neurolysin Homo sapiens 69-72 8623967-5 1996 The relationship between MEP amplitude and the level of neuromuscular block induced by vecuronium infusion was evaluated in seven patients. Vecuronium Bromide 87-97 neurolysin Homo sapiens 25-28 8623967-12 1996 We conclude that 1) intraoperative myogenic MEP monitoring is feasible during isoflurane or sevoflurane anesthesia if stimulation is performed with a short train of rectangular pulses, and 2) that electromyographic monitoring of neuromuscular block is useful to assess intraoperative MEP changes under partial neuromuscular block. Isoflurane 78-88 neurolysin Homo sapiens 44-47 8623967-12 1996 We conclude that 1) intraoperative myogenic MEP monitoring is feasible during isoflurane or sevoflurane anesthesia if stimulation is performed with a short train of rectangular pulses, and 2) that electromyographic monitoring of neuromuscular block is useful to assess intraoperative MEP changes under partial neuromuscular block. Sevoflurane 92-103 neurolysin Homo sapiens 44-47 8625879-7 1996 After apomorphine administration the patient group showed a significant increase in both EMG and MEP inhibition induced by digital stimulation. Apomorphine 6-17 neurolysin Homo sapiens 97-100 7891111-5 1995 The residual activity observed in the presence of the selective endopeptidase-24.11 inhibitor phosphoramidon was blocked by Pro-Ile or N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, inhibitors of endopeptidase-24.16 and endopeptidase-24.15, respectively. phosphoramidon 94-108 neurolysin Homo sapiens 212-231 7891111-5 1995 The residual activity observed in the presence of the selective endopeptidase-24.11 inhibitor phosphoramidon was blocked by Pro-Ile or N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, inhibitors of endopeptidase-24.16 and endopeptidase-24.15, respectively. prolylisoleucine 124-131 neurolysin Homo sapiens 212-231 7891111-5 1995 The residual activity observed in the presence of the selective endopeptidase-24.11 inhibitor phosphoramidon was blocked by Pro-Ile or N-[1-(RS)-carboxy-3-phenylpropyl]-Ala-Ala-Phe-p-aminobenzoate, inhibitors of endopeptidase-24.16 and endopeptidase-24.15, respectively. n-[1-(rs)-carboxy-3-phenylpropyl]-ala-ala-phe-p-aminobenzoate 135-196 neurolysin Homo sapiens 212-231 8413871-10 1993 Propofol and thiopental showed significantly stronger suppression of MEP, when compared to etomidate (both P < 0.01) and to methohexital (P = 0.01 and 0.05, respectively). Thiopental 13-23 neurolysin Homo sapiens 69-72 8413871-11 1993 Etomidate was the least detrimental anesthetic agent for intraoperative monitoring of magnetic MEP. Etomidate 0-9 neurolysin Homo sapiens 95-98 1747117-1 1991 Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp (Mcc = 3-carboxy-7-methoxycoumarin; Dnp = dinitrophenyl), a quenched fluorimetric substrate originally designed as a probe to measure Pz-peptidase (also called endopeptidase 24.15), was examined as a putative substrate of the neurotensin-degrading neutral metalloendopeptidase, endopeptidase 24.16. 2,4-Dinitrophenol 26-29 neurolysin Homo sapiens 308-327 1747117-2 1991 During the purification of endopeptidase 24.16 the neurotensin(1-10) and neurotensin(11-13) formation due to this enzyme was coeluted with Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp-hydrolysing activity. 2,4-Dinitrophenol 165-168 neurolysin Homo sapiens 27-46 1747117-5 1991 Furthermore, Mcc-Pro-Leu-Gly-Pro-D-Lys-Dnp hydrolysis was inhibited by a series of dipeptides with a rank of order of potencies that parallels that observed in competition experiments of tritiated neurotensin hydrolysis by brain and intestinal endopeptidase 24.16. Dipeptides 83-93 neurolysin Homo sapiens 244-263 34859998-3 2021 First, a bifunctional phenol intermediate (DN-bp) was synthesized by coupling vanillin with 4, 4"-diaminodiphenylmethane and DOPO, and the epoxy monomer (MEP) was obtained by the epoxidation reaction with DN-bp and epichlorohydrin. Phenol 22-28 neurolysin Homo sapiens 154-157 34859998-3 2021 First, a bifunctional phenol intermediate (DN-bp) was synthesized by coupling vanillin with 4, 4"-diaminodiphenylmethane and DOPO, and the epoxy monomer (MEP) was obtained by the epoxidation reaction with DN-bp and epichlorohydrin. dinoseb 205-210 neurolysin Homo sapiens 154-157 34859998-3 2021 First, a bifunctional phenol intermediate (DN-bp) was synthesized by coupling vanillin with 4, 4"-diaminodiphenylmethane and DOPO, and the epoxy monomer (MEP) was obtained by the epoxidation reaction with DN-bp and epichlorohydrin. Epichlorohydrin 215-230 neurolysin Homo sapiens 154-157 34859998-5 2021 Interestingly, the flexural strength and modulus were greatly enhanced from 72.8 MPa and 1.3 GPa to 90.3 MPa and 2.8 GPa, respectively, at 30 wt % MEP, due to the rigidity of MEP and strong intermolecular N-H hydrogen bonding interactions. Hydrogen 209-217 neurolysin Homo sapiens 147-150 34859998-5 2021 Interestingly, the flexural strength and modulus were greatly enhanced from 72.8 MPa and 1.3 GPa to 90.3 MPa and 2.8 GPa, respectively, at 30 wt % MEP, due to the rigidity of MEP and strong intermolecular N-H hydrogen bonding interactions. Hydrogen 209-217 neurolysin Homo sapiens 175-178 34924980-7 2021 We showed that changes in MEP characteristics after DI exposure were different depending on the stimulation site, but were similar for both muscles. di 52-54 neurolysin Homo sapiens 26-29 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 49-54 neurolysin Homo sapiens 34-37 34721571-5 2021 Preconditioning with cathodal HD-tDCS followed by iTBS showed a greater increase in MEP amplitude than sham cathodal HD-tDCS preconditioning and iTBS at each time postintervention point, with longer-lasting after-effects on cortical excitability. itbs 50-54 neurolysin Homo sapiens 84-87 35024004-1 2022 The crystal structures of two new polymorphs of the 1/1 pterostilbene/picolinic acid cocrystal have been analyzed by single-crystal X-ray diffraction and studied by means of DFT calculations and a set of computational tools (QTAIM, NCIplot, MEP). pterostilbene 56-69 neurolysin Homo sapiens 241-244 35024004-1 2022 The crystal structures of two new polymorphs of the 1/1 pterostilbene/picolinic acid cocrystal have been analyzed by single-crystal X-ray diffraction and studied by means of DFT calculations and a set of computational tools (QTAIM, NCIplot, MEP). picolinic acid 70-84 neurolysin Homo sapiens 241-244 34389655-0 2021 Identification and characterization of two structurally related dipeptides that enhance catalytic efficiency of neurolysin. Dipeptides 64-74 neurolysin Homo sapiens 112-122 35292343-2 2022 Continued structure-activity relationship studies on peptidomimetic small molecule activators of Nln bearing electron-donating and electron- withdrawing functionalized phenyls are explored. phenyls 168-175 neurolysin Homo sapiens 97-100 35292343-3 2022 Incorporation of fluorine or trifluoromethyl groups produces Nln activators with enhanced A50, while methoxy substitution produces derivatives with enhanced Amax. Fluorine 17-25 neurolysin Homo sapiens 61-64 35163971-1 2022 The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. Mevalonic Acid 8-18 neurolysin Homo sapiens 34-37 35163971-1 2022 The non-mevalonate or also called MEP pathway is an essential route for the biosynthesis of isoprenoid precursors in most bacteria and in microorganisms belonging to the Apicomplexa phylum, such as the parasite responsible for malaria. Terpenes 92-102 neurolysin Homo sapiens 34-37 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 124-129 neurolysin Homo sapiens 80-83 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. tap water 108-117 neurolysin Homo sapiens 4-7 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. tap water 108-117 neurolysin Homo sapiens 176-179 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. tap water 108-117 neurolysin Homo sapiens 176-179 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. Water 112-117 neurolysin Homo sapiens 4-7 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. Water 112-117 neurolysin Homo sapiens 176-179 2642194-3 1989 The MEP contents accumulated in the eggs were reduced to 2-19% after they were transferred to dechlorinated tap water for 96 h. There was a significant correlation between the MEP concentration in the water and the MEP content in the eggs. Water 112-117 neurolysin Homo sapiens 176-179 2642194-5 1989 This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily. Water 118-123 neurolysin Homo sapiens 44-47 2642194-5 1989 This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily. Water 118-123 neurolysin Homo sapiens 93-96 2642194-5 1989 This experiment clarified that increases of MEP in Oryzias eggs were greatly affected by the MEP concentration in the water, and that the hatching rate was reduced and abnormal fry increased, even though the eggs contained the MEP only temporarily. Water 118-123 neurolysin Homo sapiens 93-96 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 49-54 neurolysin Homo sapiens 80-83 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 49-54 neurolysin Homo sapiens 80-83 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 124-129 neurolysin Homo sapiens 34-37 2642194-2 1989 When Oryzias eggs were exposed to MEP-containing water, the eggs contained more MEP the higher the MEP concentration of the water, the more advanced the stage of development, and the longer the exposure. Water 124-129 neurolysin Homo sapiens 80-83 32323450-8 2021 Significant MEP inhibition after cTBS was observed in both cannabis users without CUD and non-users, while this inhibition was not seen in cannabis users with CUD. ctbs 33-37 neurolysin Homo sapiens 12-15 5845997-0 1965 [4-Methyl-5-ethylpyridazone (MEP) (Ag 147)]. 4-methyl-5-ethylpyridazone 1-27 neurolysin Homo sapiens 29-32 33288329-8 2021 RESULTS: Non-injured controls showed decreased MEP amplitude 15-30 min after spaced cTBS in both experimental sessions. bromebric acid 84-88 neurolysin Homo sapiens 47-50 33862576-9 2021 Hydrogen bonds (H-bonds) analysis was performed, and the observation suggested that the disruption of the H-bonds between MEP chains leads to an increase in the polymer matrix"s void spaces. Hydrogen 0-8 neurolysin Homo sapiens 122-125 33862576-9 2021 Hydrogen bonds (H-bonds) analysis was performed, and the observation suggested that the disruption of the H-bonds between MEP chains leads to an increase in the polymer matrix"s void spaces. Polymers 161-168 neurolysin Homo sapiens 122-125 33862576-10 2021 These void spaces are filled with diffused water molecules, leading to swelling of the MEP hydrogel. Water 43-48 neurolysin Homo sapiens 87-90 33288329-9 2021 Burn survivors showed a smaller change in MEP amplitude after spaced cTBS compared to controls 6 weeks after burn injury but no difference compared to controls 12 weeks after burn injury. bromebric acid 69-73 neurolysin Homo sapiens 42-45 33288329-10 2021 In burn survivors, there was a significant positive association between general health outcome (Short-Form Health Survey) and the change in MEP amplitude after spaced cTBS 12 weeks after injury (r=.73, p = .01). bromebric acid 167-171 neurolysin Homo sapiens 140-143 31267409-3 2020 Therefore, the primary outcome was the number of MEP alerts (AMP, AUC and MOR) in the patients without postoperative motor deficit (false positives). Adenosine Monophosphate 61-64 neurolysin Homo sapiens 49-52 33300097-2 2020 We report intraoperative MEP responses of two patients who underwent spine surgery under general anesthesia using remimazolam. remimazolam 114-125 neurolysin Homo sapiens 25-28 33300097-3 2020 CASE PRESENTATION: In case 1, MEP monitoring was successfully performed with the use of a fixed dose of remimazolam at 0.5 mg/kg/h and remifentanil at 0.2 mug/kg/min. remimazolam 104-115 neurolysin Homo sapiens 30-33 33300097-3 2020 CASE PRESENTATION: In case 1, MEP monitoring was successfully performed with the use of a fixed dose of remimazolam at 0.5 mg/kg/h and remifentanil at 0.2 mug/kg/min. Remifentanil 135-147 neurolysin Homo sapiens 30-33 33300097-6 2020 CONCLUSIONS: General anesthesia using remimazolam and remifentanil can be a valuable alternative for spine surgery with MEP monitoring by EEG to assess the optimal dose. remimazolam 38-49 neurolysin Homo sapiens 120-123 31267409-12 2020 This study is the first to evaluate the correctness of the MEP warning criteria AMP, AUC and MOR with regard to false positive monitoring results in the context of CEA. Adenosine Monophosphate 80-83 neurolysin Homo sapiens 59-62 30870801-5 2019 RESULTS: Resting MEP amplitude was larger in the amphetamine group (6M, 6F) than the non-drug and ecstasy groups (p < 0.005) in males but not females. Amphetamine 49-60 neurolysin Homo sapiens 17-20 31172823-7 2020 MIP showed a large effect size for CG (1.00) and TG (1.35), while MEP showed a moderate effect for CG (0.61) and TG (0.73); distance covered had a moderate effect size for TG (0.70). Thioguanine 113-115 neurolysin Homo sapiens 66-69 31172823-7 2020 MIP showed a large effect size for CG (1.00) and TG (1.35), while MEP showed a moderate effect for CG (0.61) and TG (0.73); distance covered had a moderate effect size for TG (0.70). Thioguanine 113-115 neurolysin Homo sapiens 66-69 31448574-4 2019 Responsive 2-dimethylamino)ethyl methacrylate)-block-2-(methacryloyloxy)ethyl phosphate (DMAEMA-b-MEP) block-co-oligomers are introduced into mesoporous films using controlled photoiniferter initiated polymerization. 2-dimethylamino)ethyl methacrylate 11-45 neurolysin Homo sapiens 98-101 31448574-4 2019 Responsive 2-dimethylamino)ethyl methacrylate)-block-2-(methacryloyloxy)ethyl phosphate (DMAEMA-b-MEP) block-co-oligomers are introduced into mesoporous films using controlled photoiniferter initiated polymerization. block-2-(methacryloyloxy)ethyl phosphate 47-87 neurolysin Homo sapiens 98-101 32231523-6 2020 Changes in MEP amplitude at 5-60 min post-cTBS and their cumulative measures in each group were calculated. ctbs 42-46 neurolysin Homo sapiens 11-14 32231523-7 2020 We also assessed the relationship between age and maximum cTBS-induced MEP suppression (DeltaMEPMax) in each group. ctbs 58-62 neurolysin Homo sapiens 71-74 31761323-0 2020 CPP-Ala-Ala-Tyr-PABA inhibitor analogs with improved selectivity for neurolysin or thimet oligopeptidase. alanyl-tyrosyl-alanine 0-15 neurolysin Homo sapiens 69-79 33543054-11 2019 Analysis by stimulation condition and MEP status found that the MEP-/active group improved by 4.2 points on FMA (P<.0001) and 1.8 on ARAT (P=.003) post intervention. fma 108-111 neurolysin Homo sapiens 64-67 33543054-11 2019 Analysis by stimulation condition and MEP status found that the MEP-/active group improved by 4.2 points on FMA (P<.0001) and 1.8 on ARAT (P=.003) post intervention. arat 133-137 neurolysin Homo sapiens 64-67 33543054-12 2019 The MEP+/active group improved by 5.7 points on FMA (P<.0001) and 3.9 points on ARAT (P<.0001) post intervention. fma 48-51 neurolysin Homo sapiens 4-7 33543054-12 2019 The MEP+/active group improved by 5.7 points on FMA (P<.0001) and 3.9 points on ARAT (P<.0001) post intervention. arat 80-84 neurolysin Homo sapiens 4-7 33543054-14 2019 Regarding MCIDs, in the MEP-/active group, 14.5% of individuals reached MCID on FMA and 8.3% on ARAT post intervention. fma 80-83 neurolysin Homo sapiens 24-27 33543054-14 2019 Regarding MCIDs, in the MEP-/active group, 14.5% of individuals reached MCID on FMA and 8.3% on ARAT post intervention. arat 96-100 neurolysin Homo sapiens 24-27 33543054-15 2019 In the MEP+/active group, 33.3% of individuals reached MCID on FMA and 27.3% on ARAT post intervention. fma 63-66 neurolysin Homo sapiens 7-10 33543054-15 2019 In the MEP+/active group, 33.3% of individuals reached MCID on FMA and 27.3% on ARAT post intervention. arat 80-84 neurolysin Homo sapiens 7-10 30870801-5 2019 RESULTS: Resting MEP amplitude was larger in the amphetamine group (6M, 6F) than the non-drug and ecstasy groups (p < 0.005) in males but not females. Amphetamines 98-105 neurolysin Homo sapiens 17-20 29867191-4 2018 iTBS-15-iTBS increased MEP amplitude for up to 60 mins post stimulation, whereas iTBS-5-iTBS decreased MEP amplitude. itbs-15-itbs 0-12 neurolysin Homo sapiens 23-26 29867191-4 2018 iTBS-15-iTBS increased MEP amplitude for up to 60 mins post stimulation, whereas iTBS-5-iTBS decreased MEP amplitude. itbs-5-itbs 81-92 neurolysin Homo sapiens 103-106 29867191-9 2018 While repeated iTBS can increase the magnitude of MEP facilitation/inhibition in some individuals compared to single iTBS, the response to repeated iTBS appears variable between individuals in this small sample. itbs 15-19 neurolysin Homo sapiens 50-53 28117933-5 2017 Significant relationships were also found between changes in DTT and abnormal MEP records at the beginning of the operation (P = 0.032) and perioperative deterioration of muscle strength (P = 0.0058). Dithiothreitol 61-64 neurolysin Homo sapiens 78-81 28525863-4 2017 Fukui calculations along with MEP plot predict the electrophilic nature of the silver cluster in the presence of pyrene, with NBO analysis revealing that the adsorption causes charge redistribution from the first three rings of pyrene towards the fourth ring, from where the 2p orbitals of carbon interact with the valence 5s orbitals of the cluster. pyrene 113-119 neurolysin Homo sapiens 30-33 30372679-5 2018 RESULTS: In healthy subjects, ccPAS - 5 protocol induced the expected long-lasting increase of MEP amplitude compatible with LTP-like cortical plasticity while PAS +5 protocol induced the opposite effect. Protactinium 32-35 neurolysin Homo sapiens 95-98 26943841-11 2017 The average MEP amplitudes in the > 90 BIS level was approximately 10 times higher than those in the < 40 BIS level. 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester 42-45 neurolysin Homo sapiens 12-15 28490237-7 2017 The xanthones biosynthetic pathway is a mixed biosynthetic pathway involved the shikimate and the malonate routes, and the seco-iridoid pathway starts with geraniol derived from IPP which is produced either via the MEP or the MVA pathway. Xanthones 4-13 neurolysin Homo sapiens 215-218 33440488-8 2017 Building upon this work, here we report an engineered metal-chelation based method to dynamically regulate mechanical and physical properties of MEP-based protein hydrogels. Metals 54-59 neurolysin Homo sapiens 145-148 33440488-9 2017 We engineered a bihistidine metal binding motif in the host domain of the MEP. bihistidine 16-27 neurolysin Homo sapiens 74-77 33440488-9 2017 We engineered a bihistidine metal binding motif in the host domain of the MEP. Metals 28-33 neurolysin Homo sapiens 74-77 33440488-10 2017 The binding of bivalent ions (such as Ni2+) enhances the thermodynamic stability of the host domain and results in the shift of the conformational equilibrium between the two mutually exclusive conformations of the MEP. Nickel(2+) 38-42 neurolysin Homo sapiens 215-218 33440488-11 2017 Thus, the bihistidine mutant can serve as a metal ion responsive-folding switch to regulate the conformational equilibrium of the MEP. bihistidine 10-21 neurolysin Homo sapiens 130-133 33440488-11 2017 Thus, the bihistidine mutant can serve as a metal ion responsive-folding switch to regulate the conformational equilibrium of the MEP. Metals 44-49 neurolysin Homo sapiens 130-133 33440488-12 2017 Using this bihistidine mutant of MEP as building blocks, we engineered chemically cross-linked protein hydrogels. bihistidine 11-22 neurolysin Homo sapiens 33-36 33440488-14 2017 This dynamic change is due to the metal chelation-induced shift of the conformational equilibrium of the MEP and consequently the effective cross-linking density of the hydrogel. Metals 34-39 neurolysin Homo sapiens 105-108 26943841-11 2017 The average MEP amplitudes in the > 90 BIS level was approximately 10 times higher than those in the < 40 BIS level. 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester 112-115 neurolysin Homo sapiens 12-15 26943841-15 2017 In addition, the deviation in MEP amplitude was also correlated with depth of anesthesia, which was smaller during awake surgery (high BIS level) than during deep anesthesia. 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester 135-138 neurolysin Homo sapiens 30-33 26253032-5 2016 RESULTS: As previously shown, PMv-M1 paired-pulse stimulation resulted in inhibition of the MEP (90% RMT, 4-6 ms) and PPC-M1 paired-pulse stimulation resulted in facilitation of the MEP (90% RMT, 4-8 ms). RMT 191-194 neurolysin Homo sapiens 182-185 26366101-8 2015 Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP. Ascorbic Acid 96-105 neurolysin Homo sapiens 154-157 32288929-7 2016 As a result, with active involvements and contribution of the MEP, local governments, enterprises, experts and monitoring instructions, the incentive plan vigorously guided and promoted BAT/BEP replication and application for medical waste disposal, avoided and reduced the generation and emission of dioxin POPs and other toxic substances. Dioxins 301-307 neurolysin Homo sapiens 62-65 25920278-1 2015 A one-pot enzymatic cascade was established to synthesize MEP, one of the key intermediates in the MEP terpenoid biosynthetic pathway. Terpenes 103-112 neurolysin Homo sapiens 58-61 25819320-0 2015 Spectroscopic investigation (FT-IR and FT-Raman), vibrational assignments, HOMO-LUMO, NBO, MEP analysis and molecular docking study of 2-(4-hydroxyphenyl)-4,5-dimethyl-1H-imidazole 3-oxide. 2-(4-hydroxyphenyl)-4,5-dimethyl-1h-imidazole 3-oxide 135-188 neurolysin Homo sapiens 91-94 25819320-7 2015 From the MEP plot, the negative charge covers the nitro group and the positive region is over the hydroxyl group and N-H part of the imidazole ring. nitro 50-55 neurolysin Homo sapiens 9-12 25819320-7 2015 From the MEP plot, the negative charge covers the nitro group and the positive region is over the hydroxyl group and N-H part of the imidazole ring. Nitrogen 117-118 neurolysin Homo sapiens 9-12 25819320-7 2015 From the MEP plot, the negative charge covers the nitro group and the positive region is over the hydroxyl group and N-H part of the imidazole ring. imidazole 133-142 neurolysin Homo sapiens 9-12 25576938-0 2015 Spectroscopic investigation (FT-IR and FT-Raman), vibrational assignments, HOMO-LUMO, NBO, MEP analysis and molecular docking study of 2-[(4-chlorobenzyl)sulfanyl]-4-(2-methylpropyl)-6-(phenylsulfanyl)-pyrimidine-5-carbonitrile, a potential chemotherapeutic agent. 2-[(4-chlorobenzyl)sulfanyl]-4-(2-methylpropyl)-6-(phenylsulfanyl)-pyrimidine-5-carbonitrile 135-227 neurolysin Homo sapiens 91-94 25576938-5 2015 From the MEP, it is evident that the negative charge covers the C N group and the positive region is over the phenyl and the pyrimidine rings. pyrimidine 125-135 neurolysin Homo sapiens 9-12 25568136-6 2015 The peptidase was purified 41-fold from HK-2 cells; the activity was sensitive to JMV-390, the chelator o-phenanthroline, and the mercury-containing compound p-chloromercuribenzoic acid (PCMB), but not to selective inhibitors against neprilysin, neurolysin and thimet oligopeptidase. jmv-390 82-89 neurolysin Homo sapiens 246-256 25568136-6 2015 The peptidase was purified 41-fold from HK-2 cells; the activity was sensitive to JMV-390, the chelator o-phenanthroline, and the mercury-containing compound p-chloromercuribenzoic acid (PCMB), but not to selective inhibitors against neprilysin, neurolysin and thimet oligopeptidase. 1,10-phenanthroline 104-120 neurolysin Homo sapiens 246-256 25568136-6 2015 The peptidase was purified 41-fold from HK-2 cells; the activity was sensitive to JMV-390, the chelator o-phenanthroline, and the mercury-containing compound p-chloromercuribenzoic acid (PCMB), but not to selective inhibitors against neprilysin, neurolysin and thimet oligopeptidase. Mercury 130-137 neurolysin Homo sapiens 246-256 25568136-6 2015 The peptidase was purified 41-fold from HK-2 cells; the activity was sensitive to JMV-390, the chelator o-phenanthroline, and the mercury-containing compound p-chloromercuribenzoic acid (PCMB), but not to selective inhibitors against neprilysin, neurolysin and thimet oligopeptidase. p-Chloromercuribenzoic Acid 187-191 neurolysin Homo sapiens 246-256 25240829-7 2015 The negative (red and yellow) regions of the MEP are related to electrophilic reactivity and the positive (blue) regions to nucleophilic reactivity, as shown in the MEP plot and the title compound has several possible sites, CN, N atom of pyrimidine ring and sulfur atoms for electrophilic attack. pyrimidine 239-249 neurolysin Homo sapiens 45-48 25240829-7 2015 The negative (red and yellow) regions of the MEP are related to electrophilic reactivity and the positive (blue) regions to nucleophilic reactivity, as shown in the MEP plot and the title compound has several possible sites, CN, N atom of pyrimidine ring and sulfur atoms for electrophilic attack. pyrimidine 239-249 neurolysin Homo sapiens 165-168 25240829-7 2015 The negative (red and yellow) regions of the MEP are related to electrophilic reactivity and the positive (blue) regions to nucleophilic reactivity, as shown in the MEP plot and the title compound has several possible sites, CN, N atom of pyrimidine ring and sulfur atoms for electrophilic attack. Sulfur 259-265 neurolysin Homo sapiens 45-48 25240829-7 2015 The negative (red and yellow) regions of the MEP are related to electrophilic reactivity and the positive (blue) regions to nucleophilic reactivity, as shown in the MEP plot and the title compound has several possible sites, CN, N atom of pyrimidine ring and sulfur atoms for electrophilic attack. Sulfur 259-265 neurolysin Homo sapiens 165-168 25920278-1 2015 A one-pot enzymatic cascade was established to synthesize MEP, one of the key intermediates in the MEP terpenoid biosynthetic pathway. Terpenes 103-112 neurolysin Homo sapiens 99-102 25920278-2 2015 D-GAP and sodium pyruvate were converted to MEP in a reaction catalyzed by DXP synthase and DXP reductoisomerase (DXR) in the presence of the coenzymes ThPP, NADPH, and Mg2+. SODIUM PYRUVATE 10-25 neurolysin Homo sapiens 44-47 25920278-2 2015 D-GAP and sodium pyruvate were converted to MEP in a reaction catalyzed by DXP synthase and DXP reductoisomerase (DXR) in the presence of the coenzymes ThPP, NADPH, and Mg2+. flopropione 152-156 neurolysin Homo sapiens 44-47 25920278-2 2015 D-GAP and sodium pyruvate were converted to MEP in a reaction catalyzed by DXP synthase and DXP reductoisomerase (DXR) in the presence of the coenzymes ThPP, NADPH, and Mg2+. NADP 158-163 neurolysin Homo sapiens 44-47 25920278-2 2015 D-GAP and sodium pyruvate were converted to MEP in a reaction catalyzed by DXP synthase and DXP reductoisomerase (DXR) in the presence of the coenzymes ThPP, NADPH, and Mg2+. magnesium ion 169-173 neurolysin Homo sapiens 44-47 25920278-4 2015 Importantly, MEP prepared by this way was totally free from contamination by minor amounts of DXP that was not completely convertible by DXR. dxp 94-97 neurolysin Homo sapiens 13-16 23676792-5 2013 After PAS, MEP amplitudes significantly increased in healthy controls compared with depressed subjects (P=0.002). Aminosalicylic Acid 6-9 neurolysin Homo sapiens 11-14 25221549-6 2014 Notably, deep sequencing also revealed that some methylotrophs dramatically increased after MEP application, strongly suggesting that these bacteria play a role in the consumption and removal of methanol, a harmful derivative from MEP-degradation, for better growth of MEP-degrading bacteria. Methanol 195-203 neurolysin Homo sapiens 92-95 25221549-6 2014 Notably, deep sequencing also revealed that some methylotrophs dramatically increased after MEP application, strongly suggesting that these bacteria play a role in the consumption and removal of methanol, a harmful derivative from MEP-degradation, for better growth of MEP-degrading bacteria. Methanol 195-203 neurolysin Homo sapiens 231-234 25221549-6 2014 Notably, deep sequencing also revealed that some methylotrophs dramatically increased after MEP application, strongly suggesting that these bacteria play a role in the consumption and removal of methanol, a harmful derivative from MEP-degradation, for better growth of MEP-degrading bacteria. Methanol 195-203 neurolysin Homo sapiens 231-234 26142174-7 2015 From the MEP map it is evident that the negative regions are localized over the sulphur atoms and N3 atom of triazole ring and the maximum positive region is localized on NH group, indicating a possible site for nucleophilic attack. Triazoles 109-117 neurolysin Homo sapiens 9-12 23318222-6 2013 Similarly, cerebellar cTBS reduced MEP amplitude and SICI in controls but not in PD patients under any condition. ctbs 22-26 neurolysin Homo sapiens 35-38 22360213-2 2012 Four dominant local oxygen topologies are identified based on the coordination environment: M-O-M and M-O-P bridges for the oxygen-decorated surface; and M-[OH]-M bridges and atop M-OH structures for the hydroxyl-decorated surface (M = In, Ga). Oxygen 20-26 neurolysin Homo sapiens 102-107 22958327-12 2012 The LCQ psychological score was significantly associated with MEP and 6MWT distance (p < 0.05). CHEMBL4755796 4-7 neurolysin Homo sapiens 62-65 22271438-7 2012 Both MIP/MEP and MVV significantly correlated with lung volumes and diffusing lung capacity for carbon monoxide. Carbon Monoxide 96-111 neurolysin Homo sapiens 9-12 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. Adenine 72-79 neurolysin Homo sapiens 204-207 22501021-8 2012 RESULTS: For the patient with a positive BTO result, MEP waves did not change until 17 minutes after temporary clip placement. bto 41-44 neurolysin Homo sapiens 53-56 22178281-6 2012 These substrates were conditioned for selective fluoride sorption by forming thorium complex with phosphate groups on bis[2-methacryloyloxy)-ethyl] phosphate (MEP). Fluorides 48-56 neurolysin Homo sapiens 159-162 22178281-6 2012 These substrates were conditioned for selective fluoride sorption by forming thorium complex with phosphate groups on bis[2-methacryloyloxy)-ethyl] phosphate (MEP). Thorium 77-84 neurolysin Homo sapiens 159-162 22178281-6 2012 These substrates were conditioned for selective fluoride sorption by forming thorium complex with phosphate groups on bis[2-methacryloyloxy)-ethyl] phosphate (MEP). Phosphates 98-107 neurolysin Homo sapiens 159-162 22178281-6 2012 These substrates were conditioned for selective fluoride sorption by forming thorium complex with phosphate groups on bis[2-methacryloyloxy)-ethyl] phosphate (MEP). bis[2-methacryloyloxy)-ethyl] phosphate 118-157 neurolysin Homo sapiens 159-162 19910248-3 2010 RESULTS: The magnitude of MEP increased by PAS in the young and middle but not in the elderly and its change was negatively correlated with the age. Aminosalicylic Acid 43-46 neurolysin Homo sapiens 26-29 19631328-2 2009 An analysis of the effect of performance of electrophoretic flow (EOF) on the changes in pH values, ionic strength, and the amount of acetonitrile modifiers helped to reveal that some silanol groups remained in the surface composite of the modified capillaries and to prove that MEP capillaries actually exerted greater EOF than MES ones. silanol 184-191 neurolysin Homo sapiens 279-282 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. Nucleosides 35-46 neurolysin Homo sapiens 204-207 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. Thymine 51-58 neurolysin Homo sapiens 204-207 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. Guanine 60-67 neurolysin Homo sapiens 204-207 32480941-10 2011 This review highlights mechanisms controlling (1) the first committed step in phytoene biosynthesis, (2) flux through the branch to synthesis of alpha- and beta-carotenes and (3) metabolic feedback signalling within and between the carotenoid, MEP and ABA pathways. (all-E) phytoene 78-86 neurolysin Homo sapiens 244-247 32480941-10 2011 This review highlights mechanisms controlling (1) the first committed step in phytoene biosynthesis, (2) flux through the branch to synthesis of alpha- and beta-carotenes and (3) metabolic feedback signalling within and between the carotenoid, MEP and ABA pathways. Abscisic Acid 252-255 neurolysin Homo sapiens 244-247 19854575-6 2010 The 5Hz-rTMS-induced MEP facilitation differed significantly being highest in MA patients. 5hz 4-7 neurolysin Homo sapiens 21-24 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. pyrimidine nucleobases 144-166 neurolysin Homo sapiens 204-207 19631328-4 2009 For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary. mono-2-(methacryloyloxy)ethyl succinate 258-261 neurolysin Homo sapiens 204-207 19631328-6 2009 An addition of methanol modifier (30%, v/v) into 10 mM borate buffer (pH 9.55 for MEP; pH 10.0 for MES) was necessary to accomplish a baseline separation of nine flavonoids in the MEP and MES capillaries. Methanol 15-23 neurolysin Homo sapiens 82-85 19631328-6 2009 An addition of methanol modifier (30%, v/v) into 10 mM borate buffer (pH 9.55 for MEP; pH 10.0 for MES) was necessary to accomplish a baseline separation of nine flavonoids in the MEP and MES capillaries. Methanol 15-23 neurolysin Homo sapiens 180-183 19631328-6 2009 An addition of methanol modifier (30%, v/v) into 10 mM borate buffer (pH 9.55 for MEP; pH 10.0 for MES) was necessary to accomplish a baseline separation of nine flavonoids in the MEP and MES capillaries. Borates 55-61 neurolysin Homo sapiens 82-85 19631328-6 2009 An addition of methanol modifier (30%, v/v) into 10 mM borate buffer (pH 9.55 for MEP; pH 10.0 for MES) was necessary to accomplish a baseline separation of nine flavonoids in the MEP and MES capillaries. Flavonoids 162-172 neurolysin Homo sapiens 180-183 19631328-8 2009 Especially in the MEP capillary, hydrophobic characteristics and pi-pi interactions with aromatic solutes were found and further improved to resolve an enantiomeric pair, catechin and epicatechin. Catechin 171-179 neurolysin Homo sapiens 18-21 19631328-8 2009 Especially in the MEP capillary, hydrophobic characteristics and pi-pi interactions with aromatic solutes were found and further improved to resolve an enantiomeric pair, catechin and epicatechin. Catechin 184-195 neurolysin Homo sapiens 18-21 16896986-3 2006 We tested the facilitation of the MEP size and CSP duration evoked by focal rTMS in eight patients before and after treatment with TPM at different doses for chronic neuropathic pain. Topiramate 131-134 neurolysin Homo sapiens 34-37 17537908-7 2007 We argue that in the leg motor cortex, facilitation of MEP responses from PAS occurred over a large range of interstimulus intervals as a result of the paired activation of sensory inputs with sustained, subthreshold activity of cortical neurons that follow a pulse of suprathreshold TMS. Aminosalicylic Acid 74-77 neurolysin Homo sapiens 55-58 17284829-3 2007 Three phosphine peptide inhibitors that selectively inhibit TOP and neurolysin on two bacterial Pz peptidases were investigated. phosphine 6-15 neurolysin Homo sapiens 68-78 16628754-4 2006 Validation by analysis of isolated peptide substrates has revealed that neurolysin recognizes the motif hydrophobic-X-Pro-Arg-hydrophobic, where Arg-hydrophobic is the scissile bond. x-pro-arg 116-125 neurolysin Homo sapiens 72-82 16821791-2 2006 Compounds 7 and 10 showed a strong photoantiproliferative activity, up to 3 orders of magnitude higher than that of the photochemotherapeutic drug 8-methoxypsoralen (8-MOP). Methoxsalen 147-164 neurolysin Homo sapiens 168-171 16774233-1 2006 [reaction: see text] Stereoselective isomerization of C-allyl glycosides into (E)-C-vinyl glycosides or (Z)-exo-glycals was carried out in the presence of the cationic iridium(I) catalyst [(Ph(2)MeP)(2)Ir(cod)PF(6)]. c-allyl glycosides 54-72 neurolysin Homo sapiens 195-198 16774233-1 2006 [reaction: see text] Stereoselective isomerization of C-allyl glycosides into (E)-C-vinyl glycosides or (Z)-exo-glycals was carried out in the presence of the cationic iridium(I) catalyst [(Ph(2)MeP)(2)Ir(cod)PF(6)]. Iridium 168-175 neurolysin Homo sapiens 195-198 16628754-4 2006 Validation by analysis of isolated peptide substrates has revealed that neurolysin recognizes the motif hydrophobic-X-Pro-Arg-hydrophobic, where Arg-hydrophobic is the scissile bond. Arginine 122-125 neurolysin Homo sapiens 72-82 16492846-6 2006 Maximum MEP amplitudes and recording success rates were observed during 4 stimuli delivered at 1000 Hz and 300 V. A significant main effect of sevoflurane concentration (0.5 versus 0.75 and 1 MAC multiple) on MEP amplitude was observed at the thenar recording site only (P < 0.05). Sevoflurane 143-154 neurolysin Homo sapiens 209-212 16492846-7 2006 In conclusion, MEP characteristics varied significantly with changes in stimulation pattern and less so with changes in sevoflurane concentration. Sevoflurane 120-131 neurolysin Homo sapiens 15-18 16492846-8 2006 The results suggest that high frequency repetitive stimulation allows intraoperative use of MEP monitoring during up to 1 MAC multiple of sevoflurane and constant infusion of remifentanil up to 0.2 microg x kg(-1) x min(-1). Sevoflurane 138-149 neurolysin Homo sapiens 92-95 16491880-1 2006 The serum drug concentrations were measured by HPLC or GC/MS in 15 patients of acute fenitrothion (MEP), an organophosphorus insecticide, intoxication. Fenitrothion 85-97 neurolysin Homo sapiens 99-102 16491880-1 2006 The serum drug concentrations were measured by HPLC or GC/MS in 15 patients of acute fenitrothion (MEP), an organophosphorus insecticide, intoxication. organophosphorus 108-124 neurolysin Homo sapiens 99-102 15647004-1 2005 Thimet oligopeptidase (TOP) is a soluble metalloendopeptidase belonging to a family of enzymes including neurolysin and neprilysin that utilize the HEXXH metal-binding motif. Metals 41-46 neurolysin Homo sapiens 105-115 15722181-3 2005 In relaxed FDI, VTC enhanced MEP responses by AM but had no significant effects on those by PL. vtc 16-19 neurolysin Homo sapiens 29-32 12706825-2 2003 Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K(M) for both enzymes. Phenylalanine 80-83 neurolysin Homo sapiens 39-46 15361618-0 2004 Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A. Ammonia 13-20 neurolysin Homo sapiens 38-41 15290416-12 2004 CONCLUSION: The results suggest that N(2)O can suppress the absolute amplitude of the MEP in patients under propofol and fentanyl anesthesia. Nitrous Oxide 37-42 neurolysin Homo sapiens 86-89 15290416-12 2004 CONCLUSION: The results suggest that N(2)O can suppress the absolute amplitude of the MEP in patients under propofol and fentanyl anesthesia. Propofol 108-116 neurolysin Homo sapiens 86-89 15290416-12 2004 CONCLUSION: The results suggest that N(2)O can suppress the absolute amplitude of the MEP in patients under propofol and fentanyl anesthesia. Fentanyl 121-129 neurolysin Homo sapiens 86-89 12706825-2 2003 Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K(M) for both enzymes. Tyrosine 29-32 neurolysin Homo sapiens 39-46 12706825-2 2003 Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K(M) for both enzymes. Alanine 87-90 neurolysin Homo sapiens 39-46 12706825-2 2003 Site-directed mutagenesis of Tyr(613) (EP24.16) or Tyr(612) (EP24.15) to either Phe or Ala promoted a strong reduction of k(cat)/K(M) for both enzymes. Tyrosine 51-54 neurolysin Homo sapiens 39-46 12199711-7 2002 Neurolysin was strongly activated by NaCl, KCl and Na2SO4, while NH4Cl and NaI have very modest effect. Sodium Chloride 37-41 neurolysin Homo sapiens 0-10 12199711-7 2002 Neurolysin was strongly activated by NaCl, KCl and Na2SO4, while NH4Cl and NaI have very modest effect. Potassium Chloride 43-46 neurolysin Homo sapiens 0-10 12199711-7 2002 Neurolysin was strongly activated by NaCl, KCl and Na2SO4, while NH4Cl and NaI have very modest effect. sodium sulfate 51-57 neurolysin Homo sapiens 0-10 12199711-9 2002 The effects of low temperature and high NaCl concentration on the hydrolytic activities of neurolysin and TOP do not seem to be a consequence of large secondary structure variation of the proteins, as indicated by the far-UV CD spectra. Sodium Chloride 40-44 neurolysin Homo sapiens 91-101 11685410-6 2001 Apomorphine administration consistently reversed all the MEP abnormalities found in PD patients. Apomorphine 0-11 neurolysin Homo sapiens 57-60 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE 165-168 neurolysin Homo sapiens 26-36 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. -eddnp 177-183 neurolysin Homo sapiens 26-36 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE 185-188 neurolysin Homo sapiens 26-36 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. ortho-Aminobenzoates 190-212 neurolysin Homo sapiens 26-36 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. n1-(2,4-dinitrophenyl)ethane-1,2-diamine 178-183 neurolysin Homo sapiens 26-36 12199711-1 2002 We report the recombinant neurolysin and thimet oligopeptidase (TOP) hydrolytic activities towards internally quenched fluorescent peptides derived from the peptide Abz-GGFLRRXQ-EDDnp (Abz, ortho-aminobenzoicacid; EDDnp, N-(2,4-dinitrophenyl) ethylenediamine), in which X was substituted by 11 different natural amino acids. N-(2,4-dinitrophenyl)ethylenediamine 221-258 neurolysin Homo sapiens 26-36 12192079-1 2002 The highly homologous endopeptidases thimet oligopeptidase and neurolysin are both restricted to short peptide substrates and share many of the same cleavage sites on bioactive and synthetic peptides. Peptides 191-199 neurolysin Homo sapiens 63-73 10489695-6 1999 The specific involvement of 55-kb plasmid in melanin production was confirmed upon re-introduction of this plasmid into one of the Mep- derivatives. Melanins 45-52 neurolysin Homo sapiens 131-134 11284698-5 2001 No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg. Phenylalanine 265-268 neurolysin Homo sapiens 290-300 11355859-4 2001 One of these substrates, Abz-NKPRRPQ-EDDnp was a specific and sensitive substrate for neurolysin (k(cat) = 7.0 s(-1), K(m) = 1.19 microM and k(cat)/K(m) = 5882 mM(-1). 4-[4-AMINO-6-(5-CHLORO-1H-INDOL-4-YLMETHYL)-[1,3,5]TRIAZIN-2-YLAMINO]-BENZONITRILE 25-28 neurolysin Homo sapiens 86-96 11355859-4 2001 One of these substrates, Abz-NKPRRPQ-EDDnp was a specific and sensitive substrate for neurolysin (k(cat) = 7.0 s(-1), K(m) = 1.19 microM and k(cat)/K(m) = 5882 mM(-1). nkprrpq-eddnp 29-42 neurolysin Homo sapiens 86-96 11355859-6 2001 Neurolysin concentrations as low as 1 pM were detected using this substrate under our conditions and its analogue Abz-NKPRAPQ-EDDnp was hydrolyzed by neurolysin with k(cat) = 14.03 s(-1), K(m) = 0.82 microM, and k(cat)/K(m) = 17,110 mM(-1). abz-nkprapq-eddnp 114-131 neurolysin Homo sapiens 0-10 11355859-6 2001 Neurolysin concentrations as low as 1 pM were detected using this substrate under our conditions and its analogue Abz-NKPRAPQ-EDDnp was hydrolyzed by neurolysin with k(cat) = 14.03 s(-1), K(m) = 0.82 microM, and k(cat)/K(m) = 17,110 mM(-1). abz-nkprapq-eddnp 114-131 neurolysin Homo sapiens 150-160 11284698-5 2001 No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg. Alanine 270-273 neurolysin Homo sapiens 290-300 11284698-5 2001 No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg. Arginine 278-281 neurolysin Homo sapiens 290-300 11284698-5 2001 No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg. Asparagine 301-304 neurolysin Homo sapiens 290-300 11284698-5 2001 No restricted specificity was found for P(1)" as found in thermolysin as well for P(1) substrate position, however the modifications at this position (P(1)) showed to have large influence on the catalytic constant and the best substrates for TOP contained at P(1), Phe, Ala, or Arg and for neurolysin Asn or Arg. Arginine 308-311 neurolysin Homo sapiens 290-300 11016880-8 2000 Also of interest, beta-Gly8-BK was neither a substrate nor an inhibitor of EP24.15, yet could still interact with EP24.16. beta-gly8-bk 18-30 neurolysin Homo sapiens 114-121 11016880-10 2000 These studies indicate subtle differences in substrate specificity between EP24.15 and EP24.16, and suggest that beta-amino acid analogues may be useful as templates for the design of selective inhibitors. beta-amino acid 113-128 neurolysin Homo sapiens 87-94 10701360-2 2000 This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stage NSCLC: mitomycin C, etoposide, and cisplatin (MEP). Cisplatin 175-184 neurolysin Homo sapiens 186-189 9735321-6 1998 These two EP24.16 isoforms were drastically inhibited by Pro-Ile and dithiothreitol and remained unaffected by a specific carboalkyl inhibitor (CFP-AAY-pAb) directed toward the related EP24.15. prolylisoleucine 57-64 neurolysin Homo sapiens 10-17 9735321-6 1998 These two EP24.16 isoforms were drastically inhibited by Pro-Ile and dithiothreitol and remained unaffected by a specific carboalkyl inhibitor (CFP-AAY-pAb) directed toward the related EP24.15. Dithiothreitol 69-83 neurolysin Homo sapiens 10-17 9735321-6 1998 These two EP24.16 isoforms were drastically inhibited by Pro-Ile and dithiothreitol and remained unaffected by a specific carboalkyl inhibitor (CFP-AAY-pAb) directed toward the related EP24.15. cfp-aay-pab 144-155 neurolysin Homo sapiens 10-17 9741788-3 1998 When TMS is performed during voluntary muscle contraction, the MEP is followed by a pause in electromyographic activity (cortical silent period, SP). TFF2 protein, human 145-147 neurolysin Homo sapiens 63-66 9182559-1 1997 Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells. Sulfhydryl Compounds 94-99 neurolysin Homo sapiens 0-19 9182559-1 1997 Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells. Sulfhydryl Compounds 94-99 neurolysin Homo sapiens 83-86 9182559-1 1997 Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells. Metals 105-110 neurolysin Homo sapiens 0-19 9182559-1 1997 Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells. Metals 105-110 neurolysin Homo sapiens 83-86