PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
15452786-2	2004	It is known that somatostatin and its analog octreotide decrease the splanchnic blood flow and have multiple inhibitory effects in different functions of the peptic system.	Octreotide	45-55	somatostatin	Sus scrofa	17-29
21110139-0	2011	Effect of high dietary copper on somatostatin and growth hormone-releasing hormone levels in the hypothalami of growing pigs.	Copper	23-29	somatostatin	Sus scrofa	33-45
21110139-1	2011	This experiment was conducted to examine the effect of dietary copper supplementation on somatostatin (SS) and growth hormone-releasing hormone (GHRH) mRNA expression levels in the hypothalami of growing pigs.	Copper	63-69	somatostatin	Sus scrofa	89-101
21110139-1	2011	This experiment was conducted to examine the effect of dietary copper supplementation on somatostatin (SS) and growth hormone-releasing hormone (GHRH) mRNA expression levels in the hypothalami of growing pigs.	Copper	63-69	somatostatin	Sus scrofa	103-105
21110139-5	2011	The results showed that the SS expression levels were lower and the GHRH levels were higher in pigs fed the diets with 125 mg/kg copper methionine (P<0.05) and 125 mg/kg copper sulfate (P<0.05), respectively, than in pigs fed the diet with 5 mg/kg copper.	Copper	129-135	somatostatin	Sus scrofa	28-30
21110139-5	2011	The results showed that the SS expression levels were lower and the GHRH levels were higher in pigs fed the diets with 125 mg/kg copper methionine (P<0.05) and 125 mg/kg copper sulfate (P<0.05), respectively, than in pigs fed the diet with 5 mg/kg copper.	Copper Sulfate	173-187	somatostatin	Sus scrofa	28-30
21110139-5	2011	The results showed that the SS expression levels were lower and the GHRH levels were higher in pigs fed the diets with 125 mg/kg copper methionine (P<0.05) and 125 mg/kg copper sulfate (P<0.05), respectively, than in pigs fed the diet with 5 mg/kg copper.	Copper	173-179	somatostatin	Sus scrofa	28-30
21110139-7	2011	The data indicated that high dietary copper could enhance GHRH mRNA expression levels and suppress SS mRNA expression levels in the hypothalami of pigs.	Copper	37-43	somatostatin	Sus scrofa	99-101
23294858-10	2013	The level of somatostatin concentration in the blood of pigs in rCap-SS group was significantly decreased at 14 dpi than other groups (P<0.05).	rcap	64-68	somatostatin	Sus scrofa	13-25
23294858-10	2013	The level of somatostatin concentration in the blood of pigs in rCap-SS group was significantly decreased at 14 dpi than other groups (P<0.05).	3-aminodiphenyleneiodium	112-115	somatostatin	Sus scrofa	13-25
6107906-0	1980	Isolation and structure of pro-somatostatin: a putative somatostatin precursor from pig hypothalamus.	Proline	27-31	somatostatin	Sus scrofa	56-68
15072550-8	2004	Given that our laboratory has shown SRIF at high and low doses stimulates cAMP production in a subpopulation of pig somatotropes, we sought to determine if this signaling pathway may be responsible for the stimulatory effect of SRIF on its own receptor expression.	Cyclic AMP	74-78	somatostatin	Sus scrofa	36-40
15072550-9	2004	The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway.	Colforsin	40-49	somatostatin	Sus scrofa	178-182
15072550-9	2004	The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway.	Colforsin	40-49	somatostatin	Sus scrofa	205-209
15072550-9	2004	The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway.	Colforsin	40-49	somatostatin	Sus scrofa	205-209
11861510-1	2002	Somatostatin (SRIF) inhibits GH release from rat somatotropes by reducing adenylate cyclase (AC) activity and the free cytosolic calcium concentration ([Ca(2+)](i)).	Calcium	129-136	somatostatin	Sus scrofa	14-18
11861510-6	2002	Both 10(-7) and 10(-15) M SRIF increased cAMP, IP turnover, and [Ca(2+)](i) in HD cells.	Cyclic AMP	41-45	somatostatin	Sus scrofa	26-30
11861510-10	2002	Therefore, SRIF stimulates GH secretion from cultured porcine somatotrope subpopulations through an AC/cAMP pathway-dependent mechanism that is seemingly independent of net increases in IP turnover or [Ca(2+)](i).	Cyclic AMP	103-107	somatostatin	Sus scrofa	11-15
22844714-7	2012	BTX injections led to a significant decrease in the number of FB+ neurons containing substance P (SP), calcitonin gene-related peptide (CGRP), calbindin (CB), somatostatin (SOM) and neuronal nitric oxide synthase (nNOS) when compared with that found in the healthy animals (19% vs. 45%, 18% vs. 36%, 0.6% vs. 3%, 0.4 vs. 4% and 0.1% vs. 6%, respectively) These data demonstrated that BTX changed the chemical coding of bladder sensory neurons, and therefore this drug should be taken into consideration when it planning experimental therapy of selected neurogenic bladder disorders.	BATRACHOTOXIN	0-3	somatostatin	Sus scrofa	159-171
22844715-6	2012	In TTX-treated animals the number of FB+ cells containing galanin (GAL), nitric oxide synthase (NOS), somatostatin (SOM) and calbindin (CB) was 2.5%, 2%, 0.25% and 0.2%, respectively and that of pituitary adenylate cyclase-activating polypeptide (PACAP)-immunoreactive (IR) cells was 43%.	Tetrodotoxin	3-6	somatostatin	Sus scrofa	102-114
15072550-9	2004	The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway.	Cyclic AMP	263-267	somatostatin	Sus scrofa	178-182
15072550-9	2004	The receptor-independent cAMP activator forskolin elevated sst1 and sst2 mRNA levels but did not affect sst5 expression, suggesting the stimulatory actions of high- and low-dose SRIF on sst1 and high-dose SRIF on sst2 mRNA levels can be mediated by activation of cAMP, whereas the stimulatory effect of high-dose SRIF on sst5 mRNA is elicited by a cAMP-independent pathway.	Cyclic AMP	263-267	somatostatin	Sus scrofa	178-182
9452143-7	1998	A saline infusion given approximately 120 min after beginning blood collection resulted in an increase in SRIF pulse frequency and a decrease in GH-AUC and GRF-AUC.	Sodium Chloride	2-8	somatostatin	Sus scrofa	106-110
8953466-5	1996	Surprisingly, during and following the exposure of AP tissue from GMP to 10-, 20-, or 40-min pulses of 10 nM SRIF alone, GH release was markedly stimulated (P < 0.05), while AP tissue from GLR only showed a weak rebound GH release after SRIF pulses.	guanosine 5'-monophosphorothioate	66-69	somatostatin	Sus scrofa	109-113
8953466-7	1996	However, concomitant exposure of AP tissue from GMP to 0.1, 1 or 10 nM SRIF during a GRF pulse markedly enhanced the GH response (P < 0.05), compared to 1 nM GRF alone, except for 1 nM SRIF which inhibited the GH response to the first GRF pulse.	guanosine 5'-monophosphorothioate	48-51	somatostatin	Sus scrofa	71-75
1978315-2	1990	infusion of somatostatin (100 micrograms as a bolus, 0.5 micrograms x kg-1 x min-1) on pancreatic exocrine secretion in response to electrical stimulation of the vagus nerves and intra-arterial infusions of acetylcholine (0.5 mg x min-1) in anesthetized pigs (17-22 kg).	Acetylcholine	207-220	somatostatin	Sus scrofa	12-24
6107906-1	1980	An octacosapeptide that we named pro-somatostatin has been isolated from acid extracts of porcine hypothalami and found to have the amino acid sequence Ser-Ala-Asn-Ser-Asn-Pro-Ala-Met-Ala-Pro-Arg-Glu-Arg-Lys-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys.	Serine	152-155	somatostatin	Sus scrofa	37-49
31952333-1	2020	Somatostatin (SOM) is the most common agent in the gastrointestinal (GI) tract that is involved in the regulation of several gastric functions, as well as in gastric disorders.	Somatostatin	14-17	somatostatin	Sus scrofa	0-12
29098163-1	2017	The aim of the present study was to define changes in the expression of somatostatin (SOM) in the sympathetic perikarya innervating the porcine stomach prepyloric area during acetylsalicylic-acid-induced gastritis (ASA) and experimentally induced hyperacidity (HCL) and following partial stomach resection (RES).	Aspirin	175-195	somatostatin	Sus scrofa	72-84
29098163-1	2017	The aim of the present study was to define changes in the expression of somatostatin (SOM) in the sympathetic perikarya innervating the porcine stomach prepyloric area during acetylsalicylic-acid-induced gastritis (ASA) and experimentally induced hyperacidity (HCL) and following partial stomach resection (RES).	Aspirin	215-218	somatostatin	Sus scrofa	72-84
29098163-1	2017	The aim of the present study was to define changes in the expression of somatostatin (SOM) in the sympathetic perikarya innervating the porcine stomach prepyloric area during acetylsalicylic-acid-induced gastritis (ASA) and experimentally induced hyperacidity (HCL) and following partial stomach resection (RES).	Hydrochloric Acid	261-264	somatostatin	Sus scrofa	72-84
26422009-8	2015	We found that LP diets supplemented with EAA resulted in decreased concentrations of plasma somatostatin (SS) (P<0.01) and plasma urea nitrogen (PUN) (P<0.001), while dietary protein levels did not affect other traits.	Amino Acids, Essential	41-44	somatostatin	Sus scrofa	92-104
6104406-3	1980	Somatostatin declined after glucose administration but was unaffected by arginine.	Glucose	28-35	somatostatin	Sus scrofa	0-12
231849-0	1979	Somatostatin inhibits gastrin release induced by antral infusion of cyclic nucleotides and bombesin in the pig.	Nucleotides, Cyclic	68-86	somatostatin	Sus scrofa	0-12
29782837-0	2018	Phenylalanine and tryptophan stimulate gastrin and somatostatin secretion and H+-K+-ATPase activity in pigs through calcium-sensing receptor.	Phenylalanine	0-13	somatostatin	Sus scrofa	51-63
29782837-0	2018	Phenylalanine and tryptophan stimulate gastrin and somatostatin secretion and H+-K+-ATPase activity in pigs through calcium-sensing receptor.	Tryptophan	18-28	somatostatin	Sus scrofa	51-63
29782837-4	2018	Perfusion of pig stomach tissues in the presence of extracellular 80 mM l-phenylalanine (Phe) or 20 mM l-tryptophan (Trp) and a CaSR agonist cinacalcet triggered gastrin and SS secretion and H+-K+-ATPase activity (P < 0.05) and increased CaSR expression (P < 0.05).	Phenylalanine	72-87	somatostatin	Sus scrofa	174-176
29782837-4	2018	Perfusion of pig stomach tissues in the presence of extracellular 80 mM l-phenylalanine (Phe) or 20 mM l-tryptophan (Trp) and a CaSR agonist cinacalcet triggered gastrin and SS secretion and H+-K+-ATPase activity (P < 0.05) and increased CaSR expression (P < 0.05).	Cinacalcet	141-151	somatostatin	Sus scrofa	174-176
29782837-6	2018	These findings indicate that Phe and Trp induce Ca2+-dependent gastrin and SS secretion and H+-K+-ATPase activity through CaSR and its downstream signaling molecule IP3R.	Phenylalanine	29-32	somatostatin	Sus scrofa	75-77
29782837-6	2018	These findings indicate that Phe and Trp induce Ca2+-dependent gastrin and SS secretion and H+-K+-ATPase activity through CaSR and its downstream signaling molecule IP3R.	Tryptophan	37-40	somatostatin	Sus scrofa	75-77