PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33061517-13	2020	Further studies are required to address eligibility for lenvatinib treatment in CP 7 patients.	lenvatinib	56-66	proline rich protein BstNI subfamily 2	Homo sapiens	80-84
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Formaldehyde	148-156	proline rich protein BstNI subfamily 2	Homo sapiens	72-76
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Paraffin	167-175	proline rich protein BstNI subfamily 2	Homo sapiens	72-76
10825149-3	2000	We took advantage of a tetracycline-regulated gene expression system to control the expression of RB2/p130 in JC virus-induced hamster brain tumor cells to study in vivo the molecular mechanisms used by pRb2/p130 to elicit its growth-suppressive function.	Tetracycline	23-35	proline rich protein BstNI subfamily 2	Homo sapiens	203-207
9776410-3	1998	To investigate the putative tumor suppressor activity of RB2/p130 more directly, we utilized a tetracycline-regulated gene expression system to control expression of the encoded protein pRb2/p130 in JC virus-induced hamster brain tumor cells and to study the effects of pRb2/p130 on the growth of such tumor cells in nude mice.	Tetracycline	95-107	proline rich protein BstNI subfamily 2	Homo sapiens	186-190
35507431-9	2022	With CuCl, a 2D network ({Cu(mu2-Cl)2Cu}(mu4-L1))n (CP7) is generated.	cuprous chloride	5-9	proline rich protein BstNI subfamily 2	Homo sapiens	52-55
35507431-9	2022	With CuCl, a 2D network ({Cu(mu2-Cl)2Cu}(mu4-L1))n (CP7) is generated.	Echothiophate Iodide	13-15	proline rich protein BstNI subfamily 2	Homo sapiens	52-55
12663518-10	2003	In down-stream of CDKI-CDK/cyclin cascade, IP6 increased hypophosphorylated levels of Rb-related proteins, pRb/p107 and pRb2/p130, and moderately decreased E2F4 but increased its binding to both pRb/p107 and pRb2/p130.	Phytic Acid	43-46	proline rich protein BstNI subfamily 2	Homo sapiens	120-124
12663518-10	2003	In down-stream of CDKI-CDK/cyclin cascade, IP6 increased hypophosphorylated levels of Rb-related proteins, pRb/p107 and pRb2/p130, and moderately decreased E2F4 but increased its binding to both pRb/p107 and pRb2/p130.	Phytic Acid	43-46	proline rich protein BstNI subfamily 2	Homo sapiens	208-212
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Formaldehyde	113-121	proline rich protein BstNI subfamily 2	Homo sapiens	89-93
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Paraffin	129-137	proline rich protein BstNI subfamily 2	Homo sapiens	89-93
11250759-1	2001	The mechanism of suberoylanilide hydroxamic acid in cell growth inhibition involved induction of pRb-2/p130 interaction and nuclear translocation with E2F-4, followed by significant repression in E2F-1 and PCNA nuclear levels, which led to inhibition in DNA synthesis in mammary epithelial cell lines.	Vorinostat	17-48	proline rich protein BstNI subfamily 2	Homo sapiens	97-102
9823308-7	1998	We also identify the COOH-terminal 35aa as being necessary for stable interaction between HDAC1 and pRb2/p130.	Carbonic Acid	21-25	proline rich protein BstNI subfamily 2	Homo sapiens	100-104
8554050-0	1996	PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.	salivary	53-61	proline rich protein BstNI subfamily 2	Homo sapiens	6-10
8554050-3	1996	The Con1 glycoprotein is encoded in exon 3 of a PRB2 allele (PRB2L CON1+) with a potential N-linked glycosylation site.	Nitrogen	69-70	proline rich protein BstNI subfamily 2	Homo sapiens	4-21
8554050-3	1996	The Con1 glycoprotein is encoded in exon 3 of a PRB2 allele (PRB2L CON1+) with a potential N-linked glycosylation site.	Nitrogen	69-70	proline rich protein BstNI subfamily 2	Homo sapiens	48-52
8554050-6	1996	A PRB2L CON1 allele contains a single nt missense change [TCT(Ser)-->CCT (Pro)] that abolishes the potential N-linked glycosylation site (NKS-->NKP) in the Con1 protein, and this explains the Con- type.	Serine	62-65	proline rich protein BstNI subfamily 2	Homo sapiens	2-12
8554050-6	1996	A PRB2L CON1 allele contains a single nt missense change [TCT(Ser)-->CCT (Pro)] that abolishes the potential N-linked glycosylation site (NKS-->NKP) in the Con1 protein, and this explains the Con- type.	Proline	74-77	proline rich protein BstNI subfamily 2	Homo sapiens	2-12
2424969-3	1986	The immunoreactivities of glycosphingolipids with two monoclonal antibodies FH2 and IB9, that define x-structure (Gal beta 1-4[Fuc alpha 1-3]GlcNAc) and sialosyl alpha 2-6galactosyl residue, respectively, were studied by a solid phase enzyme-linked immunosorbent assay and a chromatogram immunobinding assay.	Glycosphingolipids	26-44	proline rich protein BstNI subfamily 2	Homo sapiens	84-87
6870892-0	1983	Human cancer-associated gangliosides defined by a monoclonal antibody (IB9) directed to sialosyl alpha 2 leads to 6 galactosyl residue: a preliminary note.	Gangliosides	24-36	proline rich protein BstNI subfamily 2	Homo sapiens	71-74
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	nymphayol	21-30	proline rich protein BstNI subfamily 2	Homo sapiens	158-162
32650545-0	2020	Potential Metabolite Nymphayol Isolated from Water Lily (Nymphaea stellata) Flower Inhibits MCF-7 Human Breast Cancer Cell Growth via Upregulation of Cdkn2a, pRb2, p53 and Downregulation of PCNA mRNA Expressions.	Water	45-50	proline rich protein BstNI subfamily 2	Homo sapiens	158-162
32367717-6	2020	Concurrently, the CPs formed with AgX (X = NO3- (CP4 and CP5), CF3CO2- (CP6) PF6- (CP7)) exhibits 2D sheets with guest molecules (anion, solvents) inside the tight pores or between layers.	cps	18-21	proline rich protein BstNI subfamily 2	Homo sapiens	83-86
32367717-6	2020	Concurrently, the CPs formed with AgX (X = NO3- (CP4 and CP5), CF3CO2- (CP6) PF6- (CP7)) exhibits 2D sheets with guest molecules (anion, solvents) inside the tight pores or between layers.	cf3co2- (	63-72	proline rich protein BstNI subfamily 2	Homo sapiens	83-86
32367717-6	2020	Concurrently, the CPs formed with AgX (X = NO3- (CP4 and CP5), CF3CO2- (CP6) PF6- (CP7)) exhibits 2D sheets with guest molecules (anion, solvents) inside the tight pores or between layers.	) pf6	75-80	proline rich protein BstNI subfamily 2	Homo sapiens	83-86
31318367-2	2019	CP5 and CP7 represent a unique class of asymmetric compounds with no stereogenic chiral centers in terms of their global chirality, which are achieved because of an odd number of pyrenes.	Pyrenes	179-186	proline rich protein BstNI subfamily 2	Homo sapiens	8-11
31218039-4	2019	The CTMAB-Z, a modified zeolite (prepared with cetyltrimethyl ammonium bromide) alone and a mixture of CTMAB-Z and Fe(0) were used as PRB-1 and PRB-2 reactive media, respectively.	ctmab-z	4-11	proline rich protein BstNI subfamily 2	Homo sapiens	144-149
31218039-7	2019	The contrasting experiment results showed that the highest Cr(VI) removal rate (66.27%) and leaching efficiency (71.29%) were observed in the experimental group which had DL-tartaric acid and PRB-2.	chromium hexavalent ion	59-65	proline rich protein BstNI subfamily 2	Homo sapiens	192-197
28926584-7	2017	For example, T22D1.2, an orthologue of human basic salivary proline-rich protein (PRB) 2, and numr-1 (nuclear localized metal responsive) were found to be strongly up-regulated.	Metals	120-125	proline rich protein BstNI subfamily 2	Homo sapiens	51-88
30831431-7	2019	At PRB-2 (located 25 m downgradient of the DNAPL source area), TCE concentrations were much lower (13-26 mg/L) and production of cis-1,2-dichloroethene (cDCE) and some vinyl chloride (VC) was observed.	Trichloroethylene	63-66	proline rich protein BstNI subfamily 2	Homo sapiens	3-8
30831431-8	2019	Subsequent bioaugmentation with a commercial dechlorinating culture at PRB-2 improved conversion of cDCE to VC and ethene at downgradient monitoring wells over the duration of the study.	1,2-dichloroethylene	100-104	proline rich protein BstNI subfamily 2	Homo sapiens	71-76
30831431-8	2019	Subsequent bioaugmentation with a commercial dechlorinating culture at PRB-2 improved conversion of cDCE to VC and ethene at downgradient monitoring wells over the duration of the study.	Vinyl Chloride	108-110	proline rich protein BstNI subfamily 2	Homo sapiens	71-76
30831431-8	2019	Subsequent bioaugmentation with a commercial dechlorinating culture at PRB-2 improved conversion of cDCE to VC and ethene at downgradient monitoring wells over the duration of the study.	ethylene	115-121	proline rich protein BstNI subfamily 2	Homo sapiens	71-76
28619518-8	2017	In conclusion, friedelin effectively inhibit breast cancer MCF-7 cell growth, it was associated with early expression of Cdkn1a, pRb2 and activation of p53 and caspases.	friedelin	15-24	proline rich protein BstNI subfamily 2	Homo sapiens	129-133
32254775-3	2019	Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7).	copolymer	60-69	proline rich protein BstNI subfamily 2	Homo sapiens	126-129
32254775-3	2019	Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7).	peg-b-pll	71-80	proline rich protein BstNI subfamily 2	Homo sapiens	126-129
32254775-3	2019	Thus, we here report a conjugation compound consisting of a copolymer (PEG-b-PLL) and a peptide (Cys-Ile-Gln-Pro-Phe-Tyr-Pro, CP7).	Peptides	88-95	proline rich protein BstNI subfamily 2	Homo sapiens	126-129
27998951-5	2017	Validation of these proteomic data with optimized immunoblot analysis confirmed the CADA-induced change in expression of the cell cycle progression regulator pRb2 and the transcription factor c-Jun.	CADA	84-88	proline rich protein BstNI subfamily 2	Homo sapiens	158-162
28070831-9	2017	Moreover, the SUAM-14746-mediated cell cycle arrest of MCF7 cells was associated with increased pRb2/p130 protein expression and an increase in the number of cells in the quiescent G0 state, as defined by low RNA levels.	suam	14-18	proline rich protein BstNI subfamily 2	Homo sapiens	96-100
19946741-4	2010	Treatment with the gefitinib/trastuzumab combination produced, as compared with a single agent, a more prolonged blockade of AKT and MAPK activation, a more pronounced accumulation of cells in the G0/G1 phase of the cell cycle, a more significant increase in the levels of p27(kip1) and of hypophosphorylated pRb2, and a decrease in the levels of Cyclin D1 and survivin.	Gefitinib	19-28	proline rich protein BstNI subfamily 2	Homo sapiens	309-313
24658119-3	2014	AhR/RhoA activation mediated by 3MC was essential for the upregulation of retinoblastoma 2 (pRb2) and histone deacetylase 1 (HDAC1), whereas their nuclear translocation was primarily modulated by RhoA activation.	Methylcholanthrene	32-35	proline rich protein BstNI subfamily 2	Homo sapiens	92-96
24658119-7	2014	Additionally, RhoA inhibitors (statins) reversed the effect of 3MC in inhibiting DNA synthesis by decreasing the nuclear translocation of pRb2/HDAC1, leading to a recovery of the levels of cell-cycle regulatory proteins.	Methylcholanthrene	63-66	proline rich protein BstNI subfamily 2	Homo sapiens	138-142
24658119-0	2014	3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex.	Methylcholanthrene	0-20	proline rich protein BstNI subfamily 2	Homo sapiens	138-142
24269815-6	2014	SUAM-14746-induced growth inhibition was associated with G0/G1 cell cycle phase arrest and increased levels of p27(kip1) in the nuclei and the pRb2/p130 protein expression.	3-((4-(2-styrylphenoxy)butanoyl)-4-hydroxyprolyl)thiazolidine	0-10	proline rich protein BstNI subfamily 2	Homo sapiens	143-147
16007224-6	2005	Treatment of Weri-Rb1 cell line by 5-Aza-dC induced an increase in expression level of pRb2/p130, E2F1, p73 and p53.	Azacitidine	35-40	proline rich protein BstNI subfamily 2	Homo sapiens	87-91
17708530-0	2007	Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy.	spa310	56-62	proline rich protein BstNI subfamily 2	Homo sapiens	17-21
17004112-7	2007	AZD3409 also induced an increase in the expression of p27kip-1 and of hypophosphorylated forms of pRb2 in MDA-MB-468 cells that was associated with accumulation of cells in G0/G1 and the appearance of a sub-G1 peak suggestive of apoptosis.	AZD3409	0-7	proline rich protein BstNI subfamily 2	Homo sapiens	98-102
17004112-8	2007	In contrast, AZD3409 produced a G2 arrest associated with reduced expression of pRb2 in MDA-MB-361 cells.	AZD3409	13-20	proline rich protein BstNI subfamily 2	Homo sapiens	80-84
18676747-3	2008	EXPERIMENTAL DESIGN: Expression of pRb2/p130 was evaluated by immunohistochemistry on formalin-fixed, paraffin-embedded sections in 41 STSs.	Formaldehyde	86-94	proline rich protein BstNI subfamily 2	Homo sapiens	35-39
18676747-3	2008	EXPERIMENTAL DESIGN: Expression of pRb2/p130 was evaluated by immunohistochemistry on formalin-fixed, paraffin-embedded sections in 41 STSs.	Paraffin	102-110	proline rich protein BstNI subfamily 2	Homo sapiens	35-39
18676747-10	2008	CONCLUSIONS: This study shows for the first time the potential prognostic value of pRb2/130 expression evaluated on formalin-fixed, paraffin-embedded sections in STSs patients.	Formaldehyde	116-124	proline rich protein BstNI subfamily 2	Homo sapiens	83-87
18676747-10	2008	CONCLUSIONS: This study shows for the first time the potential prognostic value of pRb2/130 expression evaluated on formalin-fixed, paraffin-embedded sections in STSs patients.	Paraffin	132-140	proline rich protein BstNI subfamily 2	Homo sapiens	83-87
15585644-0	2004	pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol.	Camptothecin	56-68	proline rich protein BstNI subfamily 2	Homo sapiens	0-4
16158962-5	2005	Positive pRb2/p130 expression was detected in 89% of LCIN, 77% of HCIN and in 35% of SCC (p=0.001), whereas diffuse p107 expression was 72%, 62% and 100%, respectively (p=0.024).	lcin	53-57	proline rich protein BstNI subfamily 2	Homo sapiens	9-13
15459751-8	2005	In pRb-overexpressing cells, the arrest of cell growth was also observed in the presence of the HDAC-inhibitor TSA, suggesting that its antiproliferative activity does not rely upon the HDAC pathway, while the addition of TSA to pRb2/p130-overexpressing cells relieved growth inhibition.	trichostatin A	111-114	proline rich protein BstNI subfamily 2	Homo sapiens	229-233
15459751-8	2005	In pRb-overexpressing cells, the arrest of cell growth was also observed in the presence of the HDAC-inhibitor TSA, suggesting that its antiproliferative activity does not rely upon the HDAC pathway, while the addition of TSA to pRb2/p130-overexpressing cells relieved growth inhibition.	trichostatin A	222-225	proline rich protein BstNI subfamily 2	Homo sapiens	229-233
15585644-0	2004	pRb2/p130 decreases sensitivity to apoptosis induced by camptothecin and doxorubicin but not by taxol.	Doxorubicin	73-84	proline rich protein BstNI subfamily 2	Homo sapiens	0-4
15585644-2	2004	The purpose of this study is to investigate the possible role of pRb2/p130 in the sensitivity of ovarian cancer to camptothecin, doxorubicin, and taxol.	Camptothecin	115-127	proline rich protein BstNI subfamily 2	Homo sapiens	65-69
15585644-2	2004	The purpose of this study is to investigate the possible role of pRb2/p130 in the sensitivity of ovarian cancer to camptothecin, doxorubicin, and taxol.	Doxorubicin	129-140	proline rich protein BstNI subfamily 2	Homo sapiens	65-69
15585644-2	2004	The purpose of this study is to investigate the possible role of pRb2/p130 in the sensitivity of ovarian cancer to camptothecin, doxorubicin, and taxol.	Paclitaxel	146-151	proline rich protein BstNI subfamily 2	Homo sapiens	65-69
15585644-4	2004	RESULTS: The results reported in this study support the conclusion that overexpression of pRb2/p130 in the CAOV-3 ovarian cancer cell line lacking wild-type p53 is able to inhibit apoptosis triggered by camptothecin and doxorubicin through the c-Jun NH(2)-terminal kinase signaling transduction pathway.	Camptothecin	203-215	proline rich protein BstNI subfamily 2	Homo sapiens	90-94
15585644-4	2004	RESULTS: The results reported in this study support the conclusion that overexpression of pRb2/p130 in the CAOV-3 ovarian cancer cell line lacking wild-type p53 is able to inhibit apoptosis triggered by camptothecin and doxorubicin through the c-Jun NH(2)-terminal kinase signaling transduction pathway.	Doxorubicin	220-231	proline rich protein BstNI subfamily 2	Homo sapiens	90-94