PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 19465516-2 2009 At room temperature (RT), methacholine (MCh) or 5-hydroxytryptamine (5-HT) induced Ca(2+) oscillations and an associated contraction in small airway SMCs. Methacholine Chloride 26-38 modifier of chinchilla Mus musculus 40-43 20574911-3 2010 AHR to methacholine was measured using head-out whole-body plethysmography, and the methacholine concentration inducing a 20% decrease in pulmonary airflow (PC(20) MCh) was calculated. Methacholine Chloride 84-96 modifier of chinchilla Mus musculus 164-167 31954314-4 2020 The results showed that LYC administration significantly relieved AFB1-induced erythrocyte dysfunction by increasing the levels of red blood cell count (RBC), hemoglobin (HGB) and hematocrit (HCT), as well as reducing red blood cell volume distribution width (RDW) level, while the levels of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean platelet volume (MPV) had no significant differences among the four groups. lycopene 24-27 modifier of chinchilla Mus musculus 352-355 18425325-3 2008 Clinically therapeutic doses of CPT-11 were injected intraperitoneally into 8-week-old female MCH mice, and their ovaries were examined by the TUNEL assay to detect dead cells. Irinotecan 32-38 modifier of chinchilla Mus musculus 94-97 17872404-12 2008 A similar analysis was used after aerosol exposures to bronchoconstrictor methacholine (Mch), except that phi depended also on increased R(aw). Methacholine Chloride 74-86 modifier of chinchilla Mus musculus 88-91 17932246-6 2008 We developed a novel nonbrain-permeable MCH antagonist analog with a carboxylic acid moiety to specifically test the site of action. Carboxylic Acids 69-84 modifier of chinchilla Mus musculus 40-43 16286236-8 2006 Respiratory resistance in response to methacholine (MCh i.v.) Methacholine Chloride 38-50 modifier of chinchilla Mus musculus 52-55 35165291-2 2022 In Arabidopsis, TEs are silenced by cytosine methylation in both CpG and non-CpG contexts (mCG and mCH) and histone H3 lysine 9 methylation (H3K9me). Cytosine 36-44 modifier of chinchilla Mus musculus 99-102 35165291-4 2022 Here, we show that establishment, rather than maintenance, of mCH depends on mCG, accounting for the synergistic colocalization of these silent marks in TEs. mcg 77-80 modifier of chinchilla Mus musculus 62-65 33453999-11 2020 Acute treatment with sigma1R agonist SA4503 failed to improve recovery, whereas prolonged treatment for 48 h significantly decreased sigma1RE102Q-mCh insolubility and inhibited apoptosis. sigma1re102q 133-145 modifier of chinchilla Mus musculus 146-149 18434112-7 2008 Furthermore, bronchoconstriction following MCh stimulation was significantly reduced after Y-27632 application. Y 27632 91-98 modifier of chinchilla Mus musculus 43-46 3743383-4 1986 The corresponding low Km isozymes of MAT and SAHH form MCs-L which include RNA MCs, the intermediate Km isozymes form MC-I, and the high Km isozymes form MC-H which is glycine MC. glycine mc 168-178 modifier of chinchilla Mus musculus 154-158 33271598-1 2020 In vertebrates, DNA methylation predominantly occurs at CG dinucleotides however, widespread non-CG methylation (mCH) has been reported in mammalian embryonic stem cells and in the brain. cytidylyl-3'-5'-guanosine 56-72 modifier of chinchilla Mus musculus 113-116 33271598-2 2020 In mammals, mCH is found at CAC trinucleotides in the nervous system, where it is associated with transcriptional repression, and at CAG trinucleotides in embryonic stem cells, where it positively correlates with transcription. trinucleotides 32-46 modifier of chinchilla Mus musculus 12-15 33271598-2 2020 In mammals, mCH is found at CAC trinucleotides in the nervous system, where it is associated with transcriptional repression, and at CAG trinucleotides in embryonic stem cells, where it positively correlates with transcription. trinucleotides 137-151 modifier of chinchilla Mus musculus 12-15 31954314-4 2020 The results showed that LYC administration significantly relieved AFB1-induced erythrocyte dysfunction by increasing the levels of red blood cell count (RBC), hemoglobin (HGB) and hematocrit (HCT), as well as reducing red blood cell volume distribution width (RDW) level, while the levels of mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and mean platelet volume (MPV) had no significant differences among the four groups. Aflatoxin B1 66-70 modifier of chinchilla Mus musculus 352-355 31189060-3 2019 Besides, we also found two mechanisms, the alternative CH (aCH) mechanism and the double hydride (DH) mechanism. Acetylcholine 59-62 modifier of chinchilla Mus musculus 55-57 31189060-6 2019 For the C O double bond hydrosilylation, the rate-determining steps of the aCH and DH mechanisms are both acetone insertion into the Rh-H bond, and the order of the activation barrier is DH < aCH CH < mCH. Acetylcholine 75-78 modifier of chinchilla Mus musculus 209-212 31189060-6 2019 For the C O double bond hydrosilylation, the rate-determining steps of the aCH and DH mechanisms are both acetone insertion into the Rh-H bond, and the order of the activation barrier is DH < aCH CH < mCH. 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole 83-85 modifier of chinchilla Mus musculus 209-212 31189060-6 2019 For the C O double bond hydrosilylation, the rate-determining steps of the aCH and DH mechanisms are both acetone insertion into the Rh-H bond, and the order of the activation barrier is DH < aCH CH < mCH. Acetone 106-113 modifier of chinchilla Mus musculus 209-212 31189060-7 2019 For the C C double bond hydrosilylation, except for the mCH pathway whose rate-determining step is the hydrosilane addition reaction, the rate-determining steps of the CH, aCH, and DH pathways are Si-C reductive elimination reactions. hydrosilane 103-114 modifier of chinchilla Mus musculus 56-59 31189060-7 2019 For the C C double bond hydrosilylation, except for the mCH pathway whose rate-determining step is the hydrosilane addition reaction, the rate-determining steps of the CH, aCH, and DH pathways are Si-C reductive elimination reactions. hydrosilane 103-114 modifier of chinchilla Mus musculus 57-59 31189060-10 2019 Consequently, we concluded that the DH mechanism is adopted as the mechanism for the Rh-catalyzed hydrosilylation of the carbonyl group while the mCH or DH mechanism is adopted as the mechanism for alkenes under conditions where their active intermediates are formed. Alkenes 198-205 modifier of chinchilla Mus musculus 146-149 29193940-5 2017 Liquid petrolatum was applied to the GCN and liquid petrolatum with aqueous extract of Mch at 7% to the GE. Petrolatum 7-17 modifier of chinchilla Mus musculus 87-90 30030752-7 2019 Additionally, altered striatal responses to L-DOPA injection were observed after prolonged acupuncture and MCH treatments, which suggests that these treatment modalities influenced the compensatory mechanisms of LID. Levodopa 44-50 modifier of chinchilla Mus musculus 107-110 30030752-8 2019 In summary, present study demonstrated that acupuncture decreased LID via hypothalamic MCH using L-DOPA-administered ak/ak and 6-OHDA mouse models and that MCH administration resulted in novel antidyskinetic effects in these models. Levodopa 97-103 modifier of chinchilla Mus musculus 87-90 30030752-8 2019 In summary, present study demonstrated that acupuncture decreased LID via hypothalamic MCH using L-DOPA-administered ak/ak and 6-OHDA mouse models and that MCH administration resulted in novel antidyskinetic effects in these models. Oxidopamine 127-133 modifier of chinchilla Mus musculus 87-90 30403471-4 2018 Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). polydopamine 0-12 modifier of chinchilla Mus musculus 124-127 30403471-4 2018 Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). Hyaluronic Acid 22-37 modifier of chinchilla Mus musculus 124-127 30403471-4 2018 Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). histidinoalanine 39-41 modifier of chinchilla Mus musculus 124-127 30403471-4 2018 Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs). mil-100 64-71 modifier of chinchilla Mus musculus 124-127 30403471-6 2018 A two-stage augmented photothermal conversion capability is introduced to this nanosystem by encapsulating curcumin in MIL-100 pores and then coating HA-PDA on the surface, which confer the MCH NPs with strong photothermal conversional efficiency. Curcumin 107-115 modifier of chinchilla Mus musculus 190-193 31762684-10 2018 Enhancement in mass cell volume (MCV) level and decline in mean corpuscular hemoglobin (MCH) levels were observed in both thiamine deficient groups with respect to control. Thiamine 122-130 modifier of chinchilla Mus musculus 88-91 30032995-13 2018 Moreover, the expression of mCherry in response to the presence of ecdysteroid in water suggests that EcRE-mCh could be used for monitoring ecdysteroid activities in environmental water. Water 82-87 modifier of chinchilla Mus musculus 28-31 29193940-5 2017 Liquid petrolatum was applied to the GCN and liquid petrolatum with aqueous extract of Mch at 7% to the GE. Petrolatum 52-62 modifier of chinchilla Mus musculus 87-90 27134644-6 2016 Airway hyperresponsiveness (AHR) toward methacholine (Mch) was assessed using Buxco equipment. Methacholine Chloride 40-52 modifier of chinchilla Mus musculus 54-57 28359802-3 2017 Exposure to 500ppb As+3 for 60 d resulted in a reduction of mean corpuscular hemoglobin (MCH) levels, but did not significantly alter red blood cell (RBC) counts, hemoglobin (Hgb) levels, mean corpuscular Hgb concentrations (MCHC), or mean corpuscular volumes (MCV). 500ppb 12-18 modifier of chinchilla Mus musculus 89-92 29100279-2 2017 We have shown the safety and anti-tumor activity of a novel metronomic chemotherapy (mCH) regimen with dose-fractioned cisplatin, oral etoposide and bevacizumab, a mAb against the vasculo-endothelial-growth-factor (mPEBev regimen), in metastatic non-small-cell-lung cancer (mNSCLC). Cisplatin 119-128 modifier of chinchilla Mus musculus 85-88 28558784-16 2017 significantly suppressed all RL values of MCh at 0.78 ~ 25 mg/mL and enhanced Cdyn values of MCh at 3.125 ~ 25 mg/mL compared to OVA-sensitized and -challenged control mice. cdyn 78-82 modifier of chinchilla Mus musculus 93-96 27379098-8 2016 Airway hyperresponsiveness (AHR) to methacholine (MCh) was assessed via whole body plethysmography. Methacholine Chloride 36-48 modifier of chinchilla Mus musculus 50-53 25855162-7 2015 Membrane current analysis showed that OH cell firing increased the frequency of fast GABAergic currents in MCH cells, an effect blocked by antagonists of OH but not dynorphin or glutamate receptors, and mimicked by bath-applied OH peptide. oh peptide 228-238 modifier of chinchilla Mus musculus 107-110 25855162-8 2015 In turn, neural network imaging with a calcium indicator genetically targeted to MCH neurons showed that excitation by bath-applied OH peptides occurs in a minority of MCH cells. Calcium 39-46 modifier of chinchilla Mus musculus 81-84 22253886-8 2012 Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. Penicillins 62-72 modifier of chinchilla Mus musculus 93-96 25834514-10 2014 Treatment with 800mg/kg body weight of methanol leaf extract significantly decreased body, liver and kidney weights, red blood cells (RBC), haemoglobin (Hgb), mean cell haemoglobin (Mch), Mchc, platelet and significantly increased serum aspartate transferance (AST), vatanine tranferance(ALT) and alkaline phosphate (ALP) levels while 400mg/kg dose had no effect on these parameters. Methanol 39-47 modifier of chinchilla Mus musculus 182-185 24269761-4 2014 In this study, a cDNA fragment (mCH) encoding the 25 amino acid mature peptide was cloned from channel catfish liver, and inserted into vector pET-32a(+) to produce a construct that expressed a hexahistidine-tagged thioredoxin (trxA) fusion protein that was cleavable using enterokinase. His-His-His-His-His-His 194-207 modifier of chinchilla Mus musculus 32-35 24269761-5 2014 The trxA-mCH fusion protein was expressed in Escherichia coli BL21 (DE3) at 25 C, using 1mM IPTG for induction. Isopropyl Thiogalactoside 92-96 modifier of chinchilla Mus musculus 9-12 22253886-8 2012 Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. Penicillins 62-72 modifier of chinchilla Mus musculus 105-108 22253886-8 2012 Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. moenomycin 76-86 modifier of chinchilla Mus musculus 93-96 22253886-8 2012 Interestingly, when treated with sub-lethal concentrations of penicillin or moenomycin, both mCh-cw1 and mCh-cw2 were concentrated at the cross wall. moenomycin 76-86 modifier of chinchilla Mus musculus 105-108 21993412-8 2011 Intravenous administration of p-cresol (250-1000 nmole) into mice effectively suppressed the ex vivo platelet aggregation, whereas showed little effect on the value of RBC, hemoglobin (HGB), hematocrit, MCV, MCH, MCHC, platelets and lymphocyte counts. 4-cresol 30-38 modifier of chinchilla Mus musculus 208-211