PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31979355-4	2020	Tofogliflozin is metabolized and inactivated by five different enzymes CYP2C18, CYP3A4, CYP3A5, CYP4A11, and CYP4F3.	6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol	0-13	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	96-103
31356814-4	2020	Here, we generated knockout mice deficient in Cyp4f39, the mouse ortholog of human CYP4F22, to investigate the effects of completely abrogating the function of the fatty acid omega-hydroxylase involved in acylceramide production on skin barrier formation.	acylceramide	205-217	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	164-192
31356814-0	2020	Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production.	acylceramide	117-129	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	77-105
31514409-4	2019	The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	18-25	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	160-167
31514409-4	2019	The production of 20-HETE is elevated after the onset of both ischemic and hemorrhagic strokes; on the other hand, subjects with genetic variants in CYP4F2 and CYP4A11 that reduce 20-HETE production are more susceptible to stroke.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	180-187	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	160-167
31514409-5	2019	This review summarizes recent genetic variants in CYP4F2, and CYP4A11 influencing 20-HETE production and discusses the role of 20-HETE in hypertension and the susceptibility to the onset, progression, and prognosis of ischemic and hemorrhagic strokes.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	82-89	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	62-69
29182730-7	2018	RESULTS: In the process of acute sodium loading, after adjusting for age and 24-hour urinary sodium concentration, SNPs in CYP11B2, PRKG1, SLC8A1 genes were significantly associated with systolic BP (SBP) rising in the additive and recessive model; SNPs in CYP4A11, PRKG1, SLC8A1, and ADRB2 genes were significantly associated with diastolic BP (DBP) rising.	Sodium	33-39	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	257-264
31438982-12	2019	RESULTS: The nearly 36,043 compounds from the Traditional Chinese Medicine (TCM) database were screened against COX-2, mPGES-1 and CYP4A11 3D models, and the 17 top flavonoids were identified.	Flavonoids	165-175	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	131-138
29976573-9	2018	For known CYP4 inhibitors, in contrast, HET0016 inhibited the activities of CYP4A11 and CYP4F2 (IC50 = 0.0137-0.0182 muM); 17-octadecynoic acid reduced activities of CYP4A11, CYP4F2, CYP4F3B, and CYP4F12 to a similar extent (IC50 = 5.70-17.7 muM).	17-octadecynoic acid	123-143	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	76-83
29976573-9	2018	For known CYP4 inhibitors, in contrast, HET0016 inhibited the activities of CYP4A11 and CYP4F2 (IC50 = 0.0137-0.0182 muM); 17-octadecynoic acid reduced activities of CYP4A11, CYP4F2, CYP4F3B, and CYP4F12 to a similar extent (IC50 = 5.70-17.7 muM).	17-octadecynoic acid	123-143	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	166-173
27228076-3	2016	The CYP4V2 gene belongs to the cytochrome P450 superfamily and encodes for fatty acid omega-hydroxylase of both saturated and unsaturated fatty acids.	saturated and unsaturated fatty acids	112-149	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	75-103
29484037-1	2018	Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	70-101	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	8-15
28834279-5	2018	To further probe the specific isoforms involved in the metabolic route, endoxifen was incubated with recombinant P450s (CYP 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 3A4, 3A5 and CYP4A11).	4-hydroxy-N-desmethyltamoxifen	72-81	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	173-180
28557975-3	2017	METHODS: This study has characterised the expression of omega fatty acid metabolising enzymes CYP4A11, CYP4F11, CYP4V2 and CYP4Z1 using monoclonal antibodies we have developed.	omega fatty acid	56-72	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	94-101
29305929-0	2018	Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites.	lauric acid	68-79	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-20
29305929-1	2018	This study was designed to characterize lauric acid metabolism to facilitate the establishment of cytochrome P450 4A11 (CYP4A11) inhibition assay.	lauric acid	40-51	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	98-118
29305929-1	2018	This study was designed to characterize lauric acid metabolism to facilitate the establishment of cytochrome P450 4A11 (CYP4A11) inhibition assay.	lauric acid	40-51	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	120-127
29305929-5	2018	The production of 11-hydroxylauric acid was mediated by CYP2E1, CYP2C9, CYP2B6, CYP1A2, CYP3A4, and CYP4A11.	11-hydroxydodecanoic acid	18-39	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	100-107
29018344-3	2017	Saturated fatty acids (FA) such as lauric acid (LA), are metabolized by different cytochrome P450 isoforms to omega- and (omega-1)-hydroxy products, in humans done by CYP4A11 and CYP2E1, respectively.	Fatty Acids	0-21	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	167-174
29018344-3	2017	Saturated fatty acids (FA) such as lauric acid (LA), are metabolized by different cytochrome P450 isoforms to omega- and (omega-1)-hydroxy products, in humans done by CYP4A11 and CYP2E1, respectively.	lauric acid	35-46	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	167-174
29018344-4	2017	In the present study we aimed at elucidating the possible interactions of xanthates with two cytochrome P450 isoforms CYP4A11 and CYP2E1 involved in the metabolism of the FA.	ethylxanthate	74-83	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	118-125
29018344-5	2017	Our experiments showed that LA-omega-hydroxylation by CYP4A11 is inhibited in a competitive manner by xanthates with long alkyl chain (C12-xanthate being the most potent inhibitor).	ethylxanthate	102-111	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	54-61
29018344-5	2017	Our experiments showed that LA-omega-hydroxylation by CYP4A11 is inhibited in a competitive manner by xanthates with long alkyl chain (C12-xanthate being the most potent inhibitor).	c12-xanthate	135-147	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	54-61
29018344-9	2017	In CYP4A11 xanthate alkyl chain is exposed to the heme, thus, a potenial omega-hydroxylated xanthate product could be formed, which could inhibit in a competitive manner the hydroxylation of LA.	Heme	50-54	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	3-10
29018344-9	2017	In CYP4A11 xanthate alkyl chain is exposed to the heme, thus, a potenial omega-hydroxylated xanthate product could be formed, which could inhibit in a competitive manner the hydroxylation of LA.	ethylxanthate	11-19	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	3-10
29018344-10	2017	The observed differences of xanthates interactions with the active sites of the two similar cytochrome P450 isoforms (CYP4A11 and CYP2E1) involved in the metabolism of FA, which lead to different changes in the enzyme activity, suggest that xanthates can be used as probing tools for analyzing enzyme active sites when exploring useful and selective compounds influencing FA homeostasis.	ethylxanthate	28-37	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	118-125
29018344-10	2017	The observed differences of xanthates interactions with the active sites of the two similar cytochrome P450 isoforms (CYP4A11 and CYP2E1) involved in the metabolism of FA, which lead to different changes in the enzyme activity, suggest that xanthates can be used as probing tools for analyzing enzyme active sites when exploring useful and selective compounds influencing FA homeostasis.	ethylxanthate	241-250	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	118-125
28639228-1	2017	20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the omega-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	0-31	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	158-165
28639228-1	2017	20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the omega-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	33-40	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	158-165
28639228-1	2017	20-Hydroxyeicosatetraenoic acid (20-HETE) is generated intracellularly through the omega-hydroxylation of arachidonic acid by the cytochrome P450 (in humans, CYP4A11 and CYP4F2).	Arachidonic Acid	106-122	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	158-165
28533430-0	2017	Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.	Heme	0-4	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	37-57
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	Arachidonic Acid	105-121	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-32
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	Arachidonic Acid	105-121	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-72
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	Eicosanoids	129-139	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-32
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	Eicosanoids	129-139	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-72
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	140-171	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-32
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	140-171	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-72
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	173-180	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-32
28533430-1	2017	Cytochrome P450 (P450, CYP) 4A11 is a human fatty acid omega-hydroxylase that catalyzes the oxidation of arachidonic acid to the eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), which plays important roles in regulating blood pressure regulation.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	173-180	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-72
28611384-7	2017	Compared to the high tacrolimus group, expression levels of six cytochrome P450 enzymes, CYP1A1, CYP2B6, CYP3A5, CYP4A11, CYP19A1, and CYP17A1 were significantly higher in the low tacrolimus group.	Tacrolimus	180-190	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	113-120
27298316-0	2016	20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	0-31	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	71-97
27298316-0	2016	20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	33-37	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	71-97
27298316-1	2016	Male and female homozygous 129/Sv mice carrying four copies of the human cytochrome P450 4A11 gene (CYP4A11) under control of its native promoter (B-129/Sv-4A11(+/+)) develop hypertension (142 +- 8 versus 113 +- 7 mm Hg systolic blood pressure (BP)), and exhibit increased 20-hydroxyeicosatetraenoic acid (20-HETE) in kidney and urine.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	273-304	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	73-93
25350082-5	2015	The metabolic pathway of tofogliflozin to M1 was considered to be as follows: first, tofogliflozin was catalyzed to the primary hydroxylated derivative (M4) by CYP2C18, CYP4A11 and CYP4F3B, then M4 was oxidized to M1.	6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol	25-38	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	169-176
26558470-8	2015	Results showed that 20-HETE (1, 10, 50 muM), a CYP4A11 metabolite of arachidonic acid, significantly increased lactate dehydrogenase (LDH) release in these cells.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	20-27	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26558470-8	2015	Results showed that 20-HETE (1, 10, 50 muM), a CYP4A11 metabolite of arachidonic acid, significantly increased lactate dehydrogenase (LDH) release in these cells.	Arachidonic Acid	69-85	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26558470-13	2015	Further RT-PCR and Western blot analyses demonstrated that CYP4A11 mRNA and protein expression were significantly up-regulated in CP- (10(-4) M) treated cells compared to the clofibrate group.	Clofibrate	175-185	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	59-66
26214067-7	2015	In addition, patients whose donors carried the CYP4A11 434S variant of the F434S polymorphism displayed impaired creatinine clearance, with statistically significant differences vs. 434FF subjects throughout the whole period of study (P < 0 05, P < 0 01, P < 0 001 and P < 0 05 for 1 week, 1 month, 5 months and 1 year after grafting, respectively).	Creatinine	113-123	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26056268-3	2015	Here we identified the cytochrome P450 gene CYP4F22 (cytochrome P450, family 4, subfamily F, polypeptide 22) as the long-sought fatty acid omega-hydroxylase gene required for acylceramide production.	acylceramide	175-187	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	128-156
26056268-9	2015	In conclusion, our findings demonstrate that CYP4F22 is an ultra-long-chain fatty acid omega-hydroxylase responsible for acylceramide production and provide important insights into the molecular mechanisms of skin permeability barrier formation.	acylceramide	121-133	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	76-104
26558470-0	2015	Cisplatin-mediated cytotoxicity through inducing CYP4A 11 expression in human renal tubular epithelial cells.	Cisplatin	0-9	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	49-57
26558470-4	2015	20-Hydroxyeicosatetraenoic acid (20-HETE) is a CYP4A11 metabolite of arachidonic acid that plays an important role in renal injury.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	0-31	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26558470-4	2015	20-Hydroxyeicosatetraenoic acid (20-HETE) is a CYP4A11 metabolite of arachidonic acid that plays an important role in renal injury.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	33-40	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
26558470-4	2015	20-Hydroxyeicosatetraenoic acid (20-HETE) is a CYP4A11 metabolite of arachidonic acid that plays an important role in renal injury.	Arachidonic Acid	69-85	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	47-54
25350082-5	2015	The metabolic pathway of tofogliflozin to M1 was considered to be as follows: first, tofogliflozin was catalyzed to the primary hydroxylated derivative (M4) by CYP2C18, CYP4A11 and CYP4F3B, then M4 was oxidized to M1.	6-((4-ethylphenyl)methyl)-3',4',5',6'-tetrahydro-6'-(hydroxymethyl)spiro(isobenzofuran-1(3H),2'-(2H)pyran)-3',4',5'-triol	85-98	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	169-176
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	Arachidonic Acid	112-128	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	6-26
25203493-0	2014	Kinetic analysis of lauric acid hydroxylation by human cytochrome P450 4A11.	lauric acid	20-31	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	55-75
25061110-6	2014	Significantly greater activity was detected in preparations containing individual cytochrome P450s coexpressed with CPR (from 6.0 nmol H2O2/min/nmol P450 to 0.2 nmol/min/nmol P450); CYP1A1 was the most active, followed by CYP2D6, CYP3A4, CYP2E1, CYP4A11, CYP1A2, and CYP2C subfamily enzymes.	Hydrogen Peroxide	135-139	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	246-253
24403517-4	2014	Results showed that both hypoxia and vascular endothelial growth factor (VEGF) induce CYP4A11 gene and protein expression (the predominant 20-HETE synthases in human EPC), and this is accompanied by an increase in 20-HETE production by ~1.4- and 1.8-fold, respectively, compared with the control levels.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	139-146	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	86-93
26233909-3	2015	Human CYP4 enzymes, mainly CYP4A11, CYP4F2, and CYP4F3B, hydroxylate arachidonic acid at the omega position to form 20-HETE, which has important effects in tumor progression and on angiogenesis and blood pressure regulation in the vasculature and kidney.	Arachidonic Acid	69-85	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	27-34
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	Arachidonic Acid	112-128	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	28-35
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	134-165	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	6-26
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	134-165	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	28-35
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	167-174	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	6-26
24535879-1	2014	Human cytochrome P450 4A11 (CYP4A11) plays a role in the regulation of blood pressure through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	167-174	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	28-35
24278241-1	2013	OBJECTIVE: CYP4A11 oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor and natriuretic in humans.	Arachidonic Acid	39-55	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
24164311-1	2014	BACKGROUND: CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure.	Arachidonic Acid	99-115	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
24164311-1	2014	BACKGROUND: CYP4A11 is a member of the cytochrome P450 enzymes and is responsible for metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in the regulation of blood pressure.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	119-150	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
24278241-1	2013	OBJECTIVE: CYP4A11 oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor and natriuretic in humans.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	59-90	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	Arachidonic Acid	155-171	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	10-30
22804341-1	2012	CYP4A11, which is a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the maintenance of cardiovascular health.	Arachidonic Acid	97-113	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
22804341-1	2012	CYP4A11, which is a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the maintenance of cardiovascular health.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	117-148	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
22804341-1	2012	CYP4A11, which is a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the maintenance of cardiovascular health.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	150-157	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
24404341-4	2013	A random mutant library of CYP4A11, in which mutations were made throughout the entire coding region, was screened with luciferase activity to detect the demethylation of luciferin-4A (2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid) of CYP4A11 mutants in Escherichia coli.	luciferin-4a	171-183	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	27-34
24404341-4	2013	A random mutant library of CYP4A11, in which mutations were made throughout the entire coding region, was screened with luciferase activity to detect the demethylation of luciferin-4A (2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid) of CYP4A11 mutants in Escherichia coli.	luciferin-4a	171-183	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	254-261
24404341-4	2013	A random mutant library of CYP4A11, in which mutations were made throughout the entire coding region, was screened with luciferase activity to detect the demethylation of luciferin-4A (2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid) of CYP4A11 mutants in Escherichia coli.	2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid	185-249	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	27-34
24404341-4	2013	A random mutant library of CYP4A11, in which mutations were made throughout the entire coding region, was screened with luciferase activity to detect the demethylation of luciferin-4A (2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid) of CYP4A11 mutants in Escherichia coli.	2-[6-methoxyquinolin-2-yl]-4,5-dihydrothiazole-4-carboxylic acid	185-249	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	254-261
24404341-8	2013	These results suggest that the enzymatic activities of CYP4A11 mutants selected from directed evolution using a luminogenic P450 substrate may not demonstrate a direct correlation with the hydroxylation activities of lauric acid.	lauric acid	217-228	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	55-62
23362865-4	2013	It is further known that several P450 enzymes involved in the metabolism of arachidonic acid and eicosanoids are expressed in human kidney, CYP 4A11, 4F2, 4F8, 4F11 and 4F12.	Arachidonic Acid	76-92	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	140-148
23362865-4	2013	It is further known that several P450 enzymes involved in the metabolism of arachidonic acid and eicosanoids are expressed in human kidney, CYP 4A11, 4F2, 4F8, 4F11 and 4F12.	Eicosanoids	97-108	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	140-148
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	epoxyeicosatrienoic acids	62-87	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
21912424-1	2013	The omega-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to omega-hydroxylated EETs, endogenous peroxisome proliferator-activated receptor-alpha (PPARalpha) agonists.	eets	89-93	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
21912424-3	2013	A cytosine-for-thymidine (T8590C) variant of CYP4A11 encodes for an omega-hydroxylase with reduced activity.	cytosine-for-thymidine	2-24	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	45-52
23085321-1	2013	BACKGROUND: CYP4A11 converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which has a crucial role in the modulation of cardiovascular homeostasis.	Arachidonic Acid	29-45	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
23085321-1	2013	BACKGROUND: CYP4A11 converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which has a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	49-80	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
23085321-1	2013	BACKGROUND: CYP4A11 converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which has a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	82-89	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	Arachidonic Acid	86-102	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	Arachidonic Acid	86-102	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-75
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	106-137	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	106-137	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-75
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	139-146	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	12-19
22327816-1	2013	BACKGROUND: CYP4A11 (cytochrome P450, family 4, subfamily A, polypeptide 11) converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which plays a crucial role in the modulation of cardiovascular homeostasis.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	139-146	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-75
22173545-3	2012	Several SNPs, some recognized as functional, in human genes implicated in EETs/20-HETE biosynthesis and metabolism, such as CYP2J2 and CYP4A11, have been tested for association with blood pressure, hypertension and its long-term cardiovascular consequences in different populations, with conflicting results.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	79-86	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	135-142
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	210-217	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	10-30
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	210-217	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	32-39
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	Arachidonic Acid	155-171	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	32-39
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	177-208	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	10-30
21617944-1	2012	The human Cytochrome P450 4A11 (CYP4A11) is a major omega-hydroxylase involved in the regulation of blood pressure in the kidney through the conversion of arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE).	20-hydroxy-5,8,11,14-eicosatetraenoic acid	177-208	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	32-39
21778351-7	2011	When treated with saturated, monounsaturated, or polyunsaturated fatty acids, CYP4F3B and CYP4A11 expression remained unchanged whereas CYP4F2 and CYP4F12 expression was transiently up-regulated.	saturated,	18-28	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	90-97
21778351-7	2011	When treated with saturated, monounsaturated, or polyunsaturated fatty acids, CYP4F3B and CYP4A11 expression remained unchanged whereas CYP4F2 and CYP4F12 expression was transiently up-regulated.	monounsaturated,	29-45	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	90-97
21873888-1	2011	OBJECTIVE AND METHODS: A loss-of-function cytosine (C) for thymidine (T) transition at nucleotide 8590 of CYP4A11 has been associated with increased blood pressure in humans.	Cytosine	42-50	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	106-113
21873888-1	2011	OBJECTIVE AND METHODS: A loss-of-function cytosine (C) for thymidine (T) transition at nucleotide 8590 of CYP4A11 has been associated with increased blood pressure in humans.	Thymidine	59-68	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	106-113
21873888-2	2011	We tested the hypothesis that CYP4A11 T8590C genotype is associated with salt sensitivity in the International Hypertensive Pathotype cohort.	Salts	73-77	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	30-37
21873888-4	2011	Among normotensive individuals, CYP4A11 T8590C genotype was associated with mean arterial pressure (MAP) during both high and low salt diets, such that there was no relationship between genotype and salt sensitivity of blood pressure.	Salts	130-134	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	32-39
21873888-9	2011	CONCLUSION: The loss-of-function CYP4A11 8590C allele is associated with a diagnosis of hypertension and, in normotensive individuals, with higher blood pressure regardless of salt intake.	Salts	176-180	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	33-40
21873888-12	2011	Studies are needed to determine whether CYP4A11 T8590C genotype predicts responses to medications that affect sodium homeostasis in hypertensive individuals.	Sodium	110-116	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	40-47
20876785-9	2011	In summary, exemestane seems to be metabolized to MI by multiple P450s that include CYP4A11 and CYP1A1/2, whereas its oxidation to MII is primarily mediated by CYP3A.	exemestane	12-22	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	84-91
21120482-6	2011	RESULTS: Addition of WIT003 or overexpression of CYP4A11 with an associated increase in 20-HETE production significantly induced invasion and expression of VEGF and MMP-9.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	88-95	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	49-56
19786646-2	2009	CYP4F2 and CYP4A11 are the predominant human isoforms that synthesize 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	70-101	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
20047814-1	2010	The alkB gene encodes for alkane 1-monooxygenase, which is a key enzyme responsible for the initial oxidation of inactivated alkanes.	Alkanes	125-132	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	26-48
19615687-6	2009	Patients with substitution of phenylalanine 434 by serine (434SS, n=15, 2.04%) in CYP4A11 F434 demonstrated significantly augmented endothelium-dependent vasoconstriction (p=0.044 after Bonferroni correction) compared to patients with the 434FS (n=193, 26.29%) and 434FF genotype (n=526, 71.66%) before and after adjustment for blood pressure and HDL-cholesterol.	Cholesterol	351-362	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	82-89
19786646-2	2009	CYP4F2 and CYP4A11 are the predominant human isoforms that synthesize 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	103-110	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
19786646-2	2009	CYP4F2 and CYP4A11 are the predominant human isoforms that synthesize 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid.	Arachidonic Acid	117-133	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
19786646-8	2009	It was selective toward CYP4F2 (IC50: 1.9 micromol/L) and had reduced activity toward CYP4A11 (IC50: >150 micromol/L), as well as cytochrome P epoxygenation of arachidonic acid (IC50: >50 micromol/L).	Arachidonic Acid	163-179	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	86-93
19366684-4	2009	Dietary administration of either of the PPARalpha agonists, fenofibrate or clofibric acid, increases hepatic and renal CYP4A11 levels by 2-3-fold, and these responses were also abrogated in PPARalpha null mice.	Clofibric Acid	75-89	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	119-126
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	Arachidonic Acid	0-16	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	238-245
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	Eicosanoids	104-115	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	238-245
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	epoxyeicosatrienoic acids	124-149	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	238-245
19594405-4	2009	Arachidonic acid is metabolized via the epoxidation and omega-hydroxylation to many biologically active eicosanoids such as epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids by multiple P450 isoforms including CYP2C, CYP2E1 and CYP4A11.	Hydroxyeicosatetraenoic Acids	154-183	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	238-245
19409404-6	2009	Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1.	Steroids	87-94	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	166-173
19366684-2	2009	Expression of CYP4A11 in mice yields liver and kidney P450 4A11 levels similar to those found in the corresponding human tissues and leads to an increased microsomal capacity for omega-hydroxylation of lauric acid.	lauric acid	202-213	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	14-21
18936345-1	2008	CYP4A11 oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite with renovascular and tubular function in humans.	Arachidonic Acid	17-33	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
19366684-4	2009	Dietary administration of either of the PPARalpha agonists, fenofibrate or clofibric acid, increases hepatic and renal CYP4A11 levels by 2-3-fold, and these responses were also abrogated in PPARalpha null mice.	Fenofibrate	60-71	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	119-126
18936345-1	2008	CYP4A11 oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite with renovascular and tubular function in humans.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	37-68	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
18574070-2	2008	The CYP4A11 F434S and CYP4F2 V433M polymorphisms reduce 20-hydroxyeicosatetraenoic acid production in vitro.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	56-87	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	4-11
18566475-3	2008	Real time PCR, immunoblot analysis with a specific antipeptide antibody, and determination of fatty acid omega-hydroxylase activity demonstrate that PGA1 treatment strongly increases expression of CYP4F3B.	prostaglandin A1	149-153	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	94-122
18391101-5	2008	A thymidine-to-cytosine polymorphism in the CYP4A11 gene reduced catalytic activity by >50% in vitro and was associated with hypertension.	Thymidine	2-11	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-51
18385420-1	2008	CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor and natriuretic.	Arachidonic Acid	8-24	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
18385420-1	2008	CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid to 20-hydroxyeicosatetraenoic acid, a renal vasoconstrictor and natriuretic.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	79-110	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
18391101-5	2008	A thymidine-to-cytosine polymorphism in the CYP4A11 gene reduced catalytic activity by >50% in vitro and was associated with hypertension.	Cytosine	15-23	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-51
18391101-10	2008	The CYP4A11 CC/TC genotype was significantly associated with a reduction in 20-hydroxyeicosatetraenoic acid excretion but was not associated with blood pressure.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	76-107	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	4-11
18391101-11	2008	We have demonstrated for the first time in humans that polymorphisms of the CYP4F2 and CYP4A11 genes have opposite effects on 20-hydroxyeicosatetraenoic acid excretion.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	126-157	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	87-94
18300855-1	2008	OBJECTIVE: CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.	Arachidonic Acid	99-115	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
18484194-1	2008	OBJECTIVE: CYP4A11 is an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, which is involved in regulation of vascular tone in the brain.	Arachidonic Acid	46-62	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
18484194-1	2008	OBJECTIVE: CYP4A11 is an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, which is involved in regulation of vascular tone in the brain.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	66-97	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
18300855-1	2008	OBJECTIVE: CYP4A11, a member of the cytochrome P450 family, acts mainly as an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	119-150	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	11-18
18300855-11	2008	CONCLUSIONS: Essential hypertension is associated with the TC + TT genotype of rs1126742 in the human CYP4A11 gene.	tc + tt	59-66	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	102-109
17405690-12	2007	Renal cadmium reduces CYP4A11 and PPARs, which may be related to hypertension, sodium retention, glucose intolerance, dyslipidemia, and zinc deficiency.	Cadmium	6-13	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
17947496-4	2008	Cells transduced with adenovirus containing either CYP4A1 or CYP4A2 produced higher levels of 20-HETE, and they demonstrated increased expression levels of the adhesion molecule intercellular adhesion molecule (ICAM) (4-7-fold) and the oxidative stress marker 3-nitrotyrosine (2-3-fold) compared with cells transduced with control adenovirus.	3-nitrotyrosine	260-275	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	61-67
17405690-12	2007	Renal cadmium reduces CYP4A11 and PPARs, which may be related to hypertension, sodium retention, glucose intolerance, dyslipidemia, and zinc deficiency.	Sodium	79-85	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
17405690-12	2007	Renal cadmium reduces CYP4A11 and PPARs, which may be related to hypertension, sodium retention, glucose intolerance, dyslipidemia, and zinc deficiency.	Glucose	97-104	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
16957555-2	2006	Genetic variants of the arachidonic acid monooxygenase CYP4A11 may result in decreased synthesis of 20-hydroxyeicostatetraenoic acid (20-HETE), experimental hypertension and elevated blood pressure levels in humans.	20-hydroxyeicostatetraenoic acid	100-132	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	55-62
16945988-3	2006	The extent of 4-OH-VPA and 5-OH-VPA formation by CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C19, CYP2D6, CYP2E1, CYP4A11, CYP4F2, CYP4F3A, and CYP4F3B was only 1-8% of the levels by CYP2C9*1.	4-Hydroxyvalproic acid	14-22	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	106-113
16945988-3	2006	The extent of 4-OH-VPA and 5-OH-VPA formation by CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2C19, CYP2D6, CYP2E1, CYP4A11, CYP4F2, CYP4F3A, and CYP4F3B was only 1-8% of the levels by CYP2C9*1.	5-Hydroxyvalproic acid	27-35	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	106-113
16957555-2	2006	Genetic variants of the arachidonic acid monooxygenase CYP4A11 may result in decreased synthesis of 20-hydroxyeicostatetraenoic acid (20-HETE), experimental hypertension and elevated blood pressure levels in humans.	20-Hete	134-141	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	55-62
16141533-2	2005	The IC50 values of HET0016 for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis averaged 17.7 nM, 12.1 nM and 20.6 nM, respectively.	Hydroxyeicosatetraenoic Acids	84-88	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	52-58
16782090-4	2006	Incubations with microsomes containing human recombinant CYP450s (Supersomes) revealed that multiple CYP450 enzymes of the family 4 class are able to omega-hydroxylate phytanic acid with the following order of efficiency: CYP4F3A>CYP4F3B>CYP4F2>CYP4A11.	Phytanic Acid	168-181	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	254-261
16712844-0	2006	CYP4A11 is repressed by retinoic acid in human liver cells.	Tretinoin	24-37	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
16712844-2	2006	We studied the effects of retinoids on the regulation of CYP4A11 in the human hepatoma cell line HepaRG.	Retinoids	26-35	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	57-64
16712844-3	2006	Treatment of HepaRG cells with all-trans-retinoic acid resulted in a strong decrease in CYP4A11 gene expression and apoprotein content and, furthermore, was associated with a 50% decrease in the microsomal lauric acid hydroxylation activity.	Tretinoin	31-54	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	88-95
16712844-4	2006	Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver.	Retinoids	51-60	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	29-36
16712844-4	2006	Such a strong suppression of CYP4A11 expression by retinoids could have a major impact on fatty acid metabolism in the liver.	Fatty Acids	90-100	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	29-36
16719385-0	2006	Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection.	lauric acid 12	35-49	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	17-24
16719385-1	2006	Lauric acid serves as an endogenous substrate for the cytochrome P450 enzyme CYP4A11.	lauric acid	0-11	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	77-84
16719385-2	2006	A reverse-phase, high-performance liquid chromatography method is described for the quantification of 12-hydroxylauric acid formed enzymatically by incubation of 14C-labeled lauric acid with cDNA-expressed CYP4A11 or human liver microsomes.	12-hydroxydodecanoic acid	102-123	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	206-213
16719385-2	2006	A reverse-phase, high-performance liquid chromatography method is described for the quantification of 12-hydroxylauric acid formed enzymatically by incubation of 14C-labeled lauric acid with cDNA-expressed CYP4A11 or human liver microsomes.	lauric acid	112-123	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	206-213
16144986-1	2005	Genetic variants of the arachidonic acid monooxygenase CYP4A11 result in decreased synthesis of 20-hydroxyeicostatetraenoic acid and experimental hypertension.	20-hydroxyeicostatetraenoic acid	96-128	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	55-62
16141533-3	2005	The IC50 value for production of 11,12-epoxy-5,8,14-eicosatrienoic acid (11,12-EET) by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM, respectively.	11,12-epoxy-5,8,14-eicosatrienoic acid	33-71	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	87-93
16141533-3	2005	The IC50 value for production of 11,12-epoxy-5,8,14-eicosatrienoic acid (11,12-EET) by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM, respectively.	11,12-epoxy-5,8,14-eicosatrienoic acid	73-82	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	87-93
15611369-1	2005	BACKGROUND: The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with renovascular and tubular functions.	Arachidonic Acid	24-40	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	16-23
15611369-1	2005	BACKGROUND: The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with renovascular and tubular functions.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	100-131	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	16-23
15611369-1	2005	BACKGROUND: The CYP4A11 arachidonic acid monooxygenase oxidizes endogenous arachidonic acid (AA) to 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite with renovascular and tubular functions.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	133-140	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	16-23
15056802-0	2004	Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes.	Clofibrate	65-75	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	54-61
15895287-2	2005	Among isoforms of the CYP4A subfamily, CYP4A11 is a major lauric acid (medium-length fatty acids) omega hydroxylase and is involved in the balance of lipids in the human liver.	lauric acid	58-69	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	39-46
15895287-2	2005	Among isoforms of the CYP4A subfamily, CYP4A11 is a major lauric acid (medium-length fatty acids) omega hydroxylase and is involved in the balance of lipids in the human liver.	medium-length fatty acids	71-96	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	39-46
15056802-8	2004	Clofibrate significantly (p < 0.05) enhanced both CYP4A11 mRNA and protein by 239 +/- 30% and 154 +/- 10% of control, respectively, but did not increase CYP2E1.	Clofibrate	0-10	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	53-60
12505434-6	2003	These observations suggest the potential for involvement of Cd as a mediator of CYP4A11 expression in kidney cortex and indicate that elevations in kidney Cd content may be involved in hypertension via alteration of the expression of this particular isoform.	Cadmium	60-62	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	80-87
12505434-3	2003	Our data show associations between non-workplace Cd exposure and changes in the abundance of hepatic and renal cortical CYP4A11.	Cadmium	49-51	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	120-127
14698153-0	2004	Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.	imidazole	0-9	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	50-66
14698153-1	2004	In a previous paper, we reported that an imidazole derivative 1 exhibited a potent inhibitory activity of 20-HETE synthase (1; IC(50) value of 5.7 nM), but this compound also exhibited little selectivity for cytochrome P450s (CYPs).	imidazole	41-50	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	106-122
14640550-1	2003	In a previous paper, we reported the N-hydroxyformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.	formamidoxime	37-57	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	103-119
12865317-13	2003	CYP4A11 had little catalytic activity for the metabolism of 17beta-estradiol and estrone.	Estradiol	60-76	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
12865317-13	2003	CYP4A11 had little catalytic activity for the metabolism of 17beta-estradiol and estrone.	Estrone	81-88	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
12505434-4	2003	In liver the levels of immunochemically detectable CYP4A11 were positively correlated with tissue Cd content while in contrast CYP4A11 abundance was inversely correlated with kidney Cd burden.	Cadmium	98-100	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	51-58
12505434-7	2003	Potential mechanisms by which Cd may alter CYP4A11 expression are discussed briefly.	Cadmium	30-32	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	43-50
12505434-4	2003	In liver the levels of immunochemically detectable CYP4A11 were positively correlated with tissue Cd content while in contrast CYP4A11 abundance was inversely correlated with kidney Cd burden.	Cadmium	182-184	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	127-134
10553718-6	1999	The differences in substrate specificity between CYP4A1, CYP4A11 and CYP4A4 towards fatty acids and prostaglandins respectively are rationalized in terms of variations in active site amino residues.	Fatty Acids	84-95	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	57-64
12464261-5	2003	The PPARalpha agonist Wy14643 induced CYP4A11 mRNA in confluent cultures of HepG2 cells stably expressing the murine PPARalpha-E282G mutant.	pirinixic acid	22-29	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	38-45
12464261-7	2003	Dexamethasone induced CYP4A11 mRNA in both control and PPARalpha- E282G-expressing HepG2 cells, indicating that the induction of CYP4A11 by dexamethasone is independent of elevated PPARalpha expression.	Dexamethasone	0-13	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	22-29
12464261-7	2003	Dexamethasone induced CYP4A11 mRNA in both control and PPARalpha- E282G-expressing HepG2 cells, indicating that the induction of CYP4A11 by dexamethasone is independent of elevated PPARalpha expression.	Dexamethasone	140-153	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	129-136
11744607-11	2002	The mRNA of CYP2E1, CYP3A5, CYP3A7, CYP4A11, and CYP4B1 genes were variably expressed at baseline and following rifampin treatment.	Rifampin	112-120	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	36-43
11714595-0	2001	Discovery of a N"-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.	n"-hydroxyphenylformamidine	15-42	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	88-104
11714595-1	2001	N-(4-Butyl-2-methylphenyl)-N"-hydroxyformamidine (HET0016) was evaluated as the first potent and selective inhibitor of 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE) synthase.	n-(4-butyl-2-methylphenyl)-n"-hydroxyformamidine	0-48	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	164-181
11736898-15	2001	Although (omega-1)- and (omega)-hydroxylation of fatty acids is attributed to CYP2E1 and CYP4A11, respectively, in the liver or kidney, no omega-hydroxylation of lauric acid was observed in microsomal preparations from cultured keratinocytes.	Fatty Acids	49-60	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	89-96
10660572-5	2000	Despite the monophasic nature of renal AA omega-hydroxylation kinetics, immunochemical studies revealed participation of two P450s, CYP4F2 and CYP4A11, since antibodies to these enzymes inhibited 20-HETE formation by 65.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	196-203	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	143-150
10660572-9	2000	Our results demonstrate that CYP4F2 and CYP4A11 underlie conversion of AA to 20-HETE, a natriuretic and vasoactive eicosanoid, in human kidney.	20-hydroxy-5,8,11,14-eicosatetraenoic acid	77-84	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	40-47
10660572-9	2000	Our results demonstrate that CYP4F2 and CYP4A11 underlie conversion of AA to 20-HETE, a natriuretic and vasoactive eicosanoid, in human kidney.	Eicosanoids	115-125	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	40-47
11101007-6	2000	However, the human cell lines did display small but significant increases in CYP450 4A1 1 levels following treatment with WY-14,643 (0.1 mmol/L), indicating that the CYP 4A11 gene may be regulated by peroxisome proliferator-activated receptor alpha in humans.	wy-14	122-127	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	166-174
12124379-5	2002	CYP4A1 exhibited a preference for 8,9-EET, whereas CYP4A2, CYP4A3, and CYP4A8 preferred 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	88-97	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	51-57
11821421-4	2002	Mutation of the glutamic acid to an alanine in CYP4A1, CYP4A3, and CYP4A11 suppresses covalent heme binding.	Glutamic Acid	16-29	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	67-74
11821421-4	2002	Mutation of the glutamic acid to an alanine in CYP4A1, CYP4A3, and CYP4A11 suppresses covalent heme binding.	Alanine	36-43	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	67-74
11821421-4	2002	Mutation of the glutamic acid to an alanine in CYP4A1, CYP4A3, and CYP4A11 suppresses covalent heme binding.	Heme	95-99	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	67-74
11992637-0	2002	Associations between human liver and kidney cadmium content and immunochemically detected CYP4A11 apoprotein.	Cadmium	44-51	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	90-97
11992637-1	2002	This present study was undertaken to assess potential effects of cadmium on CYP4A11 apoprotein in human liver and kidney as detected by Western blotting using a highly specific anti-peptide antibody.	Cadmium	65-72	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	76-83
11992637-5	2002	In contrast, increased CYP4A11 apoprotein levels were found in liver samples having higher cadmium content compared to the lower cadmium content samples.	Cadmium	91-98	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	23-30
11992637-5	2002	In contrast, increased CYP4A11 apoprotein levels were found in liver samples having higher cadmium content compared to the lower cadmium content samples.	Cadmium	129-136	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	23-30
11992637-6	2002	Increased CYP4A11 levels were also found in liver samples from female donors, compared to male donors; the difference being attributable to higher female liver cadmium burden.	Cadmium	160-167	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	10-17
11992637-7	2002	In distinction to liver, lowered CYP4A11 levels were seen in the kidney cortex samples which have high cadmium content.	Cadmium	103-110	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	33-40
11992637-8	2002	It is proposed here that the difference between the absolute cadmium burden of the liver and kidney samples may be responsible for the different patterns of expression of CYP4A11 in these two tissues.	Cadmium	61-68	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	171-178
11992637-9	2002	Further, since cadmium exposure may be associated with derangement in blood pressure control, it is interesting to note the possible relationship between altered CYP4A11-dependent production of arachidonic acid hydroxy and epoxy metabolites in kidney cortex and altered control of blood pressure.	Cadmium	15-22	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	162-169
11992637-9	2002	Further, since cadmium exposure may be associated with derangement in blood pressure control, it is interesting to note the possible relationship between altered CYP4A11-dependent production of arachidonic acid hydroxy and epoxy metabolites in kidney cortex and altered control of blood pressure.	Arachidonic Acid	194-210	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	162-169
10860550-8	2000	Although several reports from other groups described that CYP4A11 preparations catalyzed omega-hydroxylation of arachidonic acid, our purified recombinant protein exhibited no activity toward arachidonic acid nor prostaglandin A(1).	Arachidonic Acid	112-128	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	58-65
10773044-7	2000	CYP4A11 expression in primary cultures of hPT cells was significantly increased after treatment for 48 h with either ethanol (50 mM) or dexamethasone (7 nM).	Ethanol	117-124	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
10773044-7	2000	CYP4A11 expression in primary cultures of hPT cells was significantly increased after treatment for 48 h with either ethanol (50 mM) or dexamethasone (7 nM).	Dexamethasone	136-149	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
10553718-6	1999	The differences in substrate specificity between CYP4A1, CYP4A11 and CYP4A4 towards fatty acids and prostaglandins respectively are rationalized in terms of variations in active site amino residues.	Prostaglandins	100-114	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	57-64
33125290-6	2021	Our in vitro metabolism study of lusutrombopag indicated that beta-oxidation was a subsequent metabolism of omega-oxidation and CYP4 enzymes, including CYP4A11, were the major isozymes contributing to omega-oxidation.	lusutrombopag	33-46	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	152-159
9722531-3	1998	The two proteins are spectroscopically indistinguishable, but wild-type CYP4A11 primarily catalyzes omega-hydroxylation, and the L131F mutant only omega-1 hydroxylation, of lauric acid.	lauric acid	173-184	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	72-79
9722531-5	1998	Wild-type CYP4A11 is inactivated by 1-aminobenzotriazole under turnover conditions but the L131F mutant is not.	1-aminobenzotriazole	36-56	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	10-17
9722531-8	1998	A further important finding is that the substituted imidazoles bind more weakly to CYP4A11 and its L131F mutant when these proteins are reduced by NADPH-cytochrome P450 reductase than by dithionite.	Imidazoles	52-62	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	83-90
9722531-8	1998	A further important finding is that the substituted imidazoles bind more weakly to CYP4A11 and its L131F mutant when these proteins are reduced by NADPH-cytochrome P450 reductase than by dithionite.	Dithionite	187-197	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	83-90
9618440-0	1998	Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11.	Arachidonic Acid	14-30	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	136-143
9618440-9	1998	The correlation (r = 0.76; P < .02) also noted between CYP4A11 content and 20-HETE formation stemmed from the relationship (r = 0.83; P < .	20-hydroxy-5,8,11,14-eicosatetraenoic acid	78-85	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	58-65
14577226-0	1998	Determination of CYP4A11-catalyzed lauric acid 12-hydroxylation by high-performance liquid chromatography with radiometric detection.	lauric acid 12	35-49	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	17-24
7798189-3	1994	This P450HL omega showed an apparent molecular weight of 52 kDa on SDS-PAGE.	Sodium Dodecyl Sulfate	67-70	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	5-17
10024026-4	1999	The substrate-binding channel identified in CYP4A11 was found to have a much more sterically restricted active site than that in CYP102 that could cause limited access of long-chain fatty acid to the ferryl oxygen leading to the preferred omega-hydroxylation.	long-chain fatty acid	171-192	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-51
10024026-4	1999	The substrate-binding channel identified in CYP4A11 was found to have a much more sterically restricted active site than that in CYP102 that could cause limited access of long-chain fatty acid to the ferryl oxygen leading to the preferred omega-hydroxylation.	Oxygen	207-213	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	44-51
10024026-5	1999	Results of docking of a common substrate, lauric acid, into the binding site of both CYP4A11 and CYP102 and molecular dynamics simulations provided additional support for this hypothesis.	lauric acid	42-53	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	85-92
10024026-6	1999	Specifically, in the CYP4A11-lauric acid simulations, the omega hydrogens were closest to the ferryl oxygen most of the time.	lauric acid	29-40	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-28
10024026-6	1999	Specifically, in the CYP4A11-lauric acid simulations, the omega hydrogens were closest to the ferryl oxygen most of the time.	Hydrogen	64-73	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-28
10024026-6	1999	Specifically, in the CYP4A11-lauric acid simulations, the omega hydrogens were closest to the ferryl oxygen most of the time.	Oxygen	101-107	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	21-28
9799565-7	1998	Upon reconstitution with P450 reductase and phospholipid, CYP4F2 converted LTB4 to 20-OH LTB4 at a turnover rate of 392 pmol/min/nmol P450, whereas the other human liver P450s tested, including CYP4A11, exhibited neglible LTB4 omega-hydroxylase activity.	20-oh ltb4	83-93	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	194-201
8914854-7	1996	Upon reconstitution with P450 reductase and cytochrome b5, CYP4A11 proved to be a potent laurate omega-hydroxylase, exhibiting a turnover rate of 45.7 nmol 12-hydroxylaurate formed/min/nmol P450 (12-fold greater than intact microsomes), while catalyzing the omega-1 hydroxylation reaction at much lower rates (5.4 nmol 11-hydroxylaurate formed/min/nmol P450).	12-hydroxylaurate	156-173	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	59-66
8914854-7	1996	Upon reconstitution with P450 reductase and cytochrome b5, CYP4A11 proved to be a potent laurate omega-hydroxylase, exhibiting a turnover rate of 45.7 nmol 12-hydroxylaurate formed/min/nmol P450 (12-fold greater than intact microsomes), while catalyzing the omega-1 hydroxylation reaction at much lower rates (5.4 nmol 11-hydroxylaurate formed/min/nmol P450).	11-hydroxylaurate	319-336	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	59-66
8914854-8	1996	Analysis of the laurate omega-hydroxylation reaction in human liver microsomes revealed kinetic parameters (a lone Km of 48.9 microM with a VMAX of 3.72 nmol 12-hydroxylaurate formed/min/nmol P450) consistent with catalysis by CYP4A11.	Laurates	16-23	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	227-234
8914854-11	1996	From the foregoing, it appears that CYP4A11 is the principle laurate omega-hydroxylating enzyme expressed in human liver.	Laurates	61-68	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	36-43
8274222-4	1993	A second variant form of CYP4A11 cDNA, designated CYP4A11v, was isolated from the same library and had a deletion of a single adenine residue, thereby extending the reading frame and resulting in a protein of 591 amino acids.	Adenine	126-133	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	25-32
8274222-6	1993	Baculovirus-mediated cDNA expression of CYP4A11 yielded a P450 protein having a lambda max of 452 nm when reduced and complexed with carbon monoxide.	Carbon Monoxide	133-148	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	40-47
8274222-10	1993	These studies indicate that CYP4A11 is a major fatty acid-metabolizing P450 that is expressed in human kidney.	Fatty Acids	47-57	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	28-35
32124935-0	2020	CYP4A11 is involved in the development of nonalcoholic fatty liver disease via ROS-induced lipid peroxidation and inflammation.	Reactive Oxygen Species	79-82	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	0-7
32124935-5	2020	Further in vitro studies demonstrated that the expression levels of CYP4A11 and the content of reactive oxygen species (ROS) were increased in free fatty acid (FFA)-stimulated HepG2 cells.	Fatty Acids, Nonesterified	143-158	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	68-75
32124935-5	2020	Further in vitro studies demonstrated that the expression levels of CYP4A11 and the content of reactive oxygen species (ROS) were increased in free fatty acid (FFA)-stimulated HepG2 cells.	Fatty Acids, Nonesterified	160-163	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	68-75
32124935-6	2020	Clofibrate, a CYP4A11 inducer, aggravated cell damage.	Clofibrate	0-10	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	14-21
32124935-7	2020	Opposite results were observed for the CYP4A11 inhibitor HET0016, which attenuated apoptosis in FFA-treated cells.	Fatty Acids, Nonesterified	96-99	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	39-46
32124935-11	2020	The data demonstrated that CYP4A11 may metabolize fatty acids to promote the production of ROS and accelerate the progression of NAFLD.	Fatty Acids	50-61	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	27-34
32124935-11	2020	The data demonstrated that CYP4A11 may metabolize fatty acids to promote the production of ROS and accelerate the progression of NAFLD.	Reactive Oxygen Species	91-94	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	27-34