PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2809601-3	1989	Deglycosylation of synaptic membranes (SMs) with endoglycosidase H, peptide:N-glycosidase F, trifluoromethane-sulfonic acid, and alkaline sodium borohydride indicated that GP50 is associated primarily, if not exclusively, with high-mannose and/or hybrid-type oligosaccharides and lacks complex N-linked and O-linked sugar chains.	trifluoromethanesulfonic acid	93-123	tumor associated calcium signal transducer 2	Homo sapiens	172-176
2809601-3	1989	Deglycosylation of synaptic membranes (SMs) with endoglycosidase H, peptide:N-glycosidase F, trifluoromethane-sulfonic acid, and alkaline sodium borohydride indicated that GP50 is associated primarily, if not exclusively, with high-mannose and/or hybrid-type oligosaccharides and lacks complex N-linked and O-linked sugar chains.	alkaline sodium borohydride	129-156	tumor associated calcium signal transducer 2	Homo sapiens	172-176
2809601-4	1989	GP50 remained associated with the membrane fraction following extraction of SMs with alkaline sodium carbonate, was partially (55%) present in the detergent phase following the phase partitioning of SMs in the presence of Triton X-114, and was resistant to proteolytic digestion with trypsin when present as a component of intact membranes.	alkaline	85-93	tumor associated calcium signal transducer 2	Homo sapiens	0-4
2809601-4	1989	GP50 remained associated with the membrane fraction following extraction of SMs with alkaline sodium carbonate, was partially (55%) present in the detergent phase following the phase partitioning of SMs in the presence of Triton X-114, and was resistant to proteolytic digestion with trypsin when present as a component of intact membranes.	sodium carbonate	94-110	tumor associated calcium signal transducer 2	Homo sapiens	0-4
2809601-4	1989	GP50 remained associated with the membrane fraction following extraction of SMs with alkaline sodium carbonate, was partially (55%) present in the detergent phase following the phase partitioning of SMs in the presence of Triton X-114, and was resistant to proteolytic digestion with trypsin when present as a component of intact membranes.	Nonidet P-40	222-234	tumor associated calcium signal transducer 2	Homo sapiens	0-4
2809601-6	1989	Sucrose gradient centrifugation of Triton X-100 extracts of SMs or of forebrain and cerebellar homogenates resolved GP50 into two fractions with sedimentation coefficients of 3.6S and 7.3S, which accounted for 45 and 55% of the total, respectively.	Sucrose	0-7	tumor associated calcium signal transducer 2	Homo sapiens	116-120
2809601-6	1989	Sucrose gradient centrifugation of Triton X-100 extracts of SMs or of forebrain and cerebellar homogenates resolved GP50 into two fractions with sedimentation coefficients of 3.6S and 7.3S, which accounted for 45 and 55% of the total, respectively.	Octoxynol	35-47	tumor associated calcium signal transducer 2	Homo sapiens	116-120
3040725-2	1987	However, transferrin was found to react with the formate radical, CO-.2, and the hydrated electron, e-aq, with second-order rate constants of 3.8 X 10(8) and 1.1 X 10(10) M-1 S-1, respectively.	formate radical	49-64	tumor associated calcium signal transducer 2	Homo sapiens	171-178
3040725-2	1987	However, transferrin was found to react with the formate radical, CO-.2, and the hydrated electron, e-aq, with second-order rate constants of 3.8 X 10(8) and 1.1 X 10(10) M-1 S-1, respectively.	e-aq	100-104	tumor associated calcium signal transducer 2	Homo sapiens	171-178
3040725-5	1987	Fe(III)-EHPG was also found to react with CO-.2 and e-aq, k = 7.3 X 10(6) and 1.1 X 10(9) M-1 S-1, respectively.	ferric sulfate	0-7	tumor associated calcium signal transducer 2	Homo sapiens	90-97
3040725-5	1987	Fe(III)-EHPG was also found to react with CO-.2 and e-aq, k = 7.3 X 10(6) and 1.1 X 10(9) M-1 S-1, respectively.	e-aq	52-56	tumor associated calcium signal transducer 2	Homo sapiens	90-97
80443-11	1978	A minor glycoprotein (gp 50), detected by PAGE of the Triton X-100 released material, appeared to be a breakdown product of the G-protein.	Octoxynol	54-66	tumor associated calcium signal transducer 2	Homo sapiens	22-27
3607022-4	1987	The quenching rate constant (at 21 degrees C) for oxygen is kq = (9.6 +/- 0.9) X 10(7) M-1 S-1, only 1 order of magnitude less than that for Zn-hematoporphyrin quenching in aqueous solution.	Oxygen	50-56	tumor associated calcium signal transducer 2	Homo sapiens	87-94
3607022-4	1987	The quenching rate constant (at 21 degrees C) for oxygen is kq = (9.6 +/- 0.9) X 10(7) M-1 S-1, only 1 order of magnitude less than that for Zn-hematoporphyrin quenching in aqueous solution.	Lys-Gln	60-62	tumor associated calcium signal transducer 2	Homo sapiens	87-94
3607022-6	1987	The corresponding data for anthraquinonesulfonate are kq = (2.1 +/- 0.3) X 10(8) M-1 S-1 and Ea = 5.8 +/- 0.6 kcal/mol.	anthraquinone sulfonate	27-49	tumor associated calcium signal transducer 2	Homo sapiens	81-88
3607022-6	1987	The corresponding data for anthraquinonesulfonate are kq = (2.1 +/- 0.3) X 10(8) M-1 S-1 and Ea = 5.8 +/- 0.6 kcal/mol.	Lys-Gln	54-56	tumor associated calcium signal transducer 2	Homo sapiens	81-88
3492870-5	1986	At 330 microM sulfatides and pH 7.0 the rate constants of Factor XII activation were 5.3 X 10(6) M-1 s-1 and 4.2 X 10(4) M-1 s-1 for kallikrein and its light chain, respectively.	Sulfoglycosphingolipids	14-24	tumor associated calcium signal transducer 2	Homo sapiens	97-128
3875484-6	1985	At 330 microM sulfatides, pH 7.0 and 100 mM NaCl the rate constants of factor XII activation were 5.34 X 10(6) M-1 s-1 and 4.17 X 10(4) M-1 s-1 for kallikrein and its light chain, respectively.	Sulfoglycosphingolipids	14-24	tumor associated calcium signal transducer 2	Homo sapiens	111-143
3875484-6	1985	At 330 microM sulfatides, pH 7.0 and 100 mM NaCl the rate constants of factor XII activation were 5.34 X 10(6) M-1 s-1 and 4.17 X 10(4) M-1 s-1 for kallikrein and its light chain, respectively.	Sodium Chloride	44-48	tumor associated calcium signal transducer 2	Homo sapiens	111-143
6715365-5	1984	The bimolecular rate constants for the complexes with heparin of Mr = 4,300 and 3,200 are, respectively, 2 X 10(7) M-1 S-1 and 3 X 10(5) M-1 S-1.	Heparin	54-61	tumor associated calcium signal transducer 2	Homo sapiens	115-144
6828465-4	1983	[3H]Glucosamine labeling demonstrated glycoproteins of 90,000 (GP90) and 50,000 (GP50) in Long strain and GP90 in the ts mutants.	Tritium	1-3	tumor associated calcium signal transducer 2	Homo sapiens	81-85
6828465-4	1983	[3H]Glucosamine labeling demonstrated glycoproteins of 90,000 (GP90) and 50,000 (GP50) in Long strain and GP90 in the ts mutants.	Glucosamine	4-15	tumor associated calcium signal transducer 2	Homo sapiens	81-85
3016293-5	1986	When PRV-infected Vero cells were incubated in the presence of tunicamycin, the gp50 that was produced had an identical molecular weight to that produced in the absence of drug.	Tunicamycin	63-74	tumor associated calcium signal transducer 2	Homo sapiens	80-84
3016293-6	1986	When infected cells were incubated in the presence of monensin, the molecular weight of gp50 was reduced from 60,000 to 45,000, but was not sensitive to endo-beta-N-acetylglucosaminidase H. These observations led to the conclusion that gp50 does not contain N-linked carbohydrate, as predicted from the DNA sequence.	n-linked carbohydrate	258-279	tumor associated calcium signal transducer 2	Homo sapiens	88-92
3016293-7	1986	A region of the amino acid sequence and the positions of the cysteine residues of PRV gp50 are homologous to glycoprotein D of herpes simplex virus.	Cysteine	61-69	tumor associated calcium signal transducer 2	Homo sapiens	86-90
2981536-3	1985	Desferal also reacts with superoxide radical with a second-order rate constant approximately equal to 3 X 10(2) M-1 s-1 at pH 10.2 and approximately 9 X 10(2) M-1 s-1 at physiological pH.	Deferoxamine	0-8	tumor associated calcium signal transducer 2	Homo sapiens	112-119
2981536-3	1985	Desferal also reacts with superoxide radical with a second-order rate constant approximately equal to 3 X 10(2) M-1 s-1 at pH 10.2 and approximately 9 X 10(2) M-1 s-1 at physiological pH.	Deferoxamine	0-8	tumor associated calcium signal transducer 2	Homo sapiens	159-166
2981536-3	1985	Desferal also reacts with superoxide radical with a second-order rate constant approximately equal to 3 X 10(2) M-1 s-1 at pH 10.2 and approximately 9 X 10(2) M-1 s-1 at physiological pH.	Superoxides	26-44	tumor associated calcium signal transducer 2	Homo sapiens	112-119
2981536-3	1985	Desferal also reacts with superoxide radical with a second-order rate constant approximately equal to 3 X 10(2) M-1 s-1 at pH 10.2 and approximately 9 X 10(2) M-1 s-1 at physiological pH.	Superoxides	26-44	tumor associated calcium signal transducer 2	Homo sapiens	159-166
2981536-5	1985	The ability of desferal to react with hydroxyl radical (k2 approximately 10(10) M-1 s-1) is a far more likely source of error in the interpretation of results using this chelating agent.	Deferoxamine	15-23	tumor associated calcium signal transducer 2	Homo sapiens	80-87
2981536-5	1985	The ability of desferal to react with hydroxyl radical (k2 approximately 10(10) M-1 s-1) is a far more likely source of error in the interpretation of results using this chelating agent.	Hydroxyl Radical	38-54	tumor associated calcium signal transducer 2	Homo sapiens	80-87
6442108-3	1984	The reaction was found to be first order in EGTA and complex order in calcium, with an observed second-order rate constant (pH 7, T = 25 degrees C, ionic strength = 0.1 M) of about 1.5 X 10(6) M-1 s-1.	Egtazic Acid	44-48	tumor associated calcium signal transducer 2	Homo sapiens	193-200
6442108-3	1984	The reaction was found to be first order in EGTA and complex order in calcium, with an observed second-order rate constant (pH 7, T = 25 degrees C, ionic strength = 0.1 M) of about 1.5 X 10(6) M-1 s-1.	Calcium	70-77	tumor associated calcium signal transducer 2	Homo sapiens	193-200
6442108-4	1984	The rate constant was independent of hydrogen ion concentration between pH 5.8 and 7.3; above pH 7.3 it increased in magnitude with increasing pH, and was 2.0 X 10(8) M-1 s-1 at pH 8.4.	Hydrogen	37-45	tumor associated calcium signal transducer 2	Homo sapiens	167-174
6706998-3	1984	The inhibition rate constant for the scavenging of peroxy radical was calculated at 37 degrees C as kinh = 5.1 X 10(5) M-1 s-1 and 7.5 X 10(4) M-1 s-1 for vitamin E and vitamin C, respectively.	Oxygen	51-65	tumor associated calcium signal transducer 2	Homo sapiens	119-150
6706998-3	1984	The inhibition rate constant for the scavenging of peroxy radical was calculated at 37 degrees C as kinh = 5.1 X 10(5) M-1 s-1 and 7.5 X 10(4) M-1 s-1 for vitamin E and vitamin C, respectively.	Vitamin E	155-164	tumor associated calcium signal transducer 2	Homo sapiens	119-150
6706998-3	1984	The inhibition rate constant for the scavenging of peroxy radical was calculated at 37 degrees C as kinh = 5.1 X 10(5) M-1 s-1 and 7.5 X 10(4) M-1 s-1 for vitamin E and vitamin C, respectively.	Ascorbic Acid	169-178	tumor associated calcium signal transducer 2	Homo sapiens	119-150
6324859-5	1984	All arsenic nucleotides detected showed similar kinetic and equilibrium constants of formation: about 8 X 10(-4) M-1 S-1 and 2 X 10(-3) M-1, respectively.	arsenic nucleotides	4-23	tumor associated calcium signal transducer 2	Homo sapiens	113-139
6411706-6	1983	According to the model the intermediate forms with a second order rate constant of about 30 M-1 S-1 and is probably described as a ternary complex of copper, buffer, and one or more of the histidine ligands of the binding site.	Copper	150-156	tumor associated calcium signal transducer 2	Homo sapiens	92-99
6411706-6	1983	According to the model the intermediate forms with a second order rate constant of about 30 M-1 S-1 and is probably described as a ternary complex of copper, buffer, and one or more of the histidine ligands of the binding site.	Histidine	189-198	tumor associated calcium signal transducer 2	Homo sapiens	92-99
14158-3	1977	The pH- and pD-independent acylation rate constants are, respectively, 1.40 X 10(4) M-1S-1 and 1.23 X 10(4) M-1S-1 for p-nitrophenyl p-nitrobenzoate, and, respectively, 2.19 X 10(3) M-1S-1 and 1968 X 10(3) M-1S-1 for p-nitrophenyl benzoate at 25 degrees.	4-nitrophenyl 4-nitrobenzoate	119-148	tumor associated calcium signal transducer 2	Homo sapiens	84-96
305907-1	1978	Both eaq- and .OH have been found to react with 8-methoxypsoralen (8-MOP), giving rate-constants of 1.1 X 10(10) M-1 s-1.	6-~{tert}-butyl-~{N}-[6-(1~{H}-pyrazol-4-yl)-1~{H}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide	5-8	tumor associated calcium signal transducer 2	Homo sapiens	113-120
305907-1	1978	Both eaq- and .OH have been found to react with 8-methoxypsoralen (8-MOP), giving rate-constants of 1.1 X 10(10) M-1 s-1.	Methoxsalen	48-65	tumor associated calcium signal transducer 2	Homo sapiens	113-120
305907-1	1978	Both eaq- and .OH have been found to react with 8-methoxypsoralen (8-MOP), giving rate-constants of 1.1 X 10(10) M-1 s-1.	Methoxsalen	67-72	tumor associated calcium signal transducer 2	Homo sapiens	113-120
14158-3	1977	The pH- and pD-independent acylation rate constants are, respectively, 1.40 X 10(4) M-1S-1 and 1.23 X 10(4) M-1S-1 for p-nitrophenyl p-nitrobenzoate, and, respectively, 2.19 X 10(3) M-1S-1 and 1968 X 10(3) M-1S-1 for p-nitrophenyl benzoate at 25 degrees.	1s	110-112	tumor associated calcium signal transducer 2	Homo sapiens	84-96
14158-3	1977	The pH- and pD-independent acylation rate constants are, respectively, 1.40 X 10(4) M-1S-1 and 1.23 X 10(4) M-1S-1 for p-nitrophenyl p-nitrobenzoate, and, respectively, 2.19 X 10(3) M-1S-1 and 1968 X 10(3) M-1S-1 for p-nitrophenyl benzoate at 25 degrees.	1s	110-112	tumor associated calcium signal transducer 2	Homo sapiens	84-96
14158-3	1977	The pH- and pD-independent acylation rate constants are, respectively, 1.40 X 10(4) M-1S-1 and 1.23 X 10(4) M-1S-1 for p-nitrophenyl p-nitrobenzoate, and, respectively, 2.19 X 10(3) M-1S-1 and 1968 X 10(3) M-1S-1 for p-nitrophenyl benzoate at 25 degrees.	4-Nitrophenyl benzoate	217-239	tumor associated calcium signal transducer 2	Homo sapiens	84-96
33983696-5	2021	Also, 2 targeted therapies-olaparib (Lynparza) and talazoparib (Talzenna)-are FDA approved for the management of mTNBC with germline BRCA mutations, and sacituzumab govitecan, an anti-Trop2 antibody-drug conjugate (ADC), was recently approved for previously treated mTNBC.	talazoparib	51-62	tumor associated calcium signal transducer 2	Homo sapiens	184-189
33741442-0	2021	Sacituzumab Govitecan, a Trop-2-Directed Antibody-Drug Conjugate, for Patients with Epithelial Cancer: Final Safety and Efficacy Results from the Phase 1/2 IMMU-132-01 Basket Trial.	govitecan	12-21	tumor associated calcium signal transducer 2	Homo sapiens	25-31
33929895-2	2021	Sacituzumab govitecan (SG) is a TROP-2-directed antibody-drug conjugate with an SN-38 payload that has shown preliminary activity in mUC.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	32-38
33597275-1	2021	The TROP2-directed antibody-drug conjugate datopotamab deruxtecan may be active in patients with advanced or metastatic non-small cell lung cancer, according to preliminary findings.	Deruxtecan	55-65	tumor associated calcium signal transducer 2	Homo sapiens	4-9
32726711-9	2021	We also found that Trop-2 is a target of miR-125b in placental cells; its localization in the basal part of the syncytiotrophoblast plasma membrane suggests a role for it in the early onset of PE.	mir-125b	41-49	tumor associated calcium signal transducer 2	Homo sapiens	19-25
33882206-2	2021	Sacituzumab govitecan is an antibody-drug conjugate composed of an antibody targeting the human trophoblast cell-surface antigen 2 (Trop-2), which is expressed in the majority of breast cancers, coupled to SN-38 (topoisomerase I inhibitor) through a proprietary hydrolyzable linker.	Irinotecan	206-211	tumor associated calcium signal transducer 2	Homo sapiens	132-138
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	ammonium ferrous sulfate	43-49	tumor associated calcium signal transducer 2	Homo sapiens	108-115
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	fulvic acid	54-65	tumor associated calcium signal transducer 2	Homo sapiens	108-115
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	ammonium ferrous sulfate	66-72	tumor associated calcium signal transducer 2	Homo sapiens	108-115
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Oxygen	82-84	tumor associated calcium signal transducer 2	Homo sapiens	108-115
33486087-6	2021	We estimate the rate constants for albumin-Fe(II) and fulvic acid-Fe(II) mediated O2.- reduction (1.9+-0.3) M-1 s-1 and (2.7+-0.3) M-1s-1 (pH = 5.5, T = 37 oC), 17 - 25 times the rate for free iron, which we measured to be (110+-20)x10-3 M-1s-1, in agreement with the literature.	Iron	193-197	tumor associated calcium signal transducer 2	Homo sapiens	108-115
32618744-4	2021	In the last few years HER2/neu, folic acid-alpha (FRalpha) and Trop-2 overexpression have been exploited as excellent targets by novel ADCs such as Trastuzumab emtansine (T-DM1), SYD985, IMGN853 (Mirvetuximab soravtansine) and Sacituzumab govitecan (SG, IMMU-132) in multiple tumors including ovarian, endometrial and cervical cancers.	Maytansine	209-221	tumor associated calcium signal transducer 2	Homo sapiens	63-69
33300065-3	2021	The established anti-TROP2 mAb, TrMab-6 (mouse IgG2b, kappa), detected TROP2 on PA-tagged TROP2-overexpressing Chinese hamster ovary-K1 (CHO/TROP2-PA) and breast cancer cell lines, including MCF7 and BT-474 using flow cytometry.	Protactinium	80-82	tumor associated calcium signal transducer 2	Homo sapiens	21-26
33300065-3	2021	The established anti-TROP2 mAb, TrMab-6 (mouse IgG2b, kappa), detected TROP2 on PA-tagged TROP2-overexpressing Chinese hamster ovary-K1 (CHO/TROP2-PA) and breast cancer cell lines, including MCF7 and BT-474 using flow cytometry.	Protactinium	80-82	tumor associated calcium signal transducer 2	Homo sapiens	71-76
33300065-3	2021	The established anti-TROP2 mAb, TrMab-6 (mouse IgG2b, kappa), detected TROP2 on PA-tagged TROP2-overexpressing Chinese hamster ovary-K1 (CHO/TROP2-PA) and breast cancer cell lines, including MCF7 and BT-474 using flow cytometry.	Protactinium	80-82	tumor associated calcium signal transducer 2	Homo sapiens	71-76
33300065-3	2021	The established anti-TROP2 mAb, TrMab-6 (mouse IgG2b, kappa), detected TROP2 on PA-tagged TROP2-overexpressing Chinese hamster ovary-K1 (CHO/TROP2-PA) and breast cancer cell lines, including MCF7 and BT-474 using flow cytometry.	Protactinium	80-82	tumor associated calcium signal transducer 2	Homo sapiens	71-76
32726711-10	2021	Altogether, maternal miR-125b proved a promising early biomarker of PE, suggesting that it may be involved in placental development through its action on Trop-2 well before the clinical manifestations of PE.	mir-125b	21-29	tumor associated calcium signal transducer 2	Homo sapiens	154-160
33376883-4	2020	Moreover, dual-color dSTORM imaging revealed significant colocalization of Trop2 and lipid rafts, and methyl-beta-cyclodextrin disruption dramatically impaired the formation of Trop2 clusters, indicating a key role of lipid rafts in Trop2 clustering.	methyl-beta-cyclodextrin	102-126	tumor associated calcium signal transducer 2	Homo sapiens	177-182
33376883-4	2020	Moreover, dual-color dSTORM imaging revealed significant colocalization of Trop2 and lipid rafts, and methyl-beta-cyclodextrin disruption dramatically impaired the formation of Trop2 clusters, indicating a key role of lipid rafts in Trop2 clustering.	methyl-beta-cyclodextrin	102-126	tumor associated calcium signal transducer 2	Homo sapiens	177-182
32497356-6	2020	RESULTS: Our data reveal that previously identified facultative progenitors marked by Trop2, Sca-1, KRT4, and PSCA are actually luminal epithelial cells of the urethra that extend into the proximal region of the prostate, and are resistant to castration-induced androgen deprivation.	Phenobarbital	128-135	tumor associated calcium signal transducer 2	Homo sapiens	86-91
32768481-0	2020	Trop2 inhibition of P16 expression and the cell cycle promotes intracellular calcium release in OSCC.	Calcium	77-84	tumor associated calcium signal transducer 2	Homo sapiens	0-5
32768481-1	2020	Trop2 is an intracellular calcium signal transducer and a prognostic biomarker in many cancers.	Calcium	26-33	tumor associated calcium signal transducer 2	Homo sapiens	0-5
32768481-5	2020	We aimed to examine the function of Trop2 and P16 in regulating intracellular calcium ions and the cell cycle in OSCC cell lines.	Calcium	78-85	tumor associated calcium signal transducer 2	Homo sapiens	36-41
32768481-7	2020	Trop2 promoted intracellular calcium ion release in OSCC and induced S phase of the cell cycle.	Calcium	29-36	tumor associated calcium signal transducer 2	Homo sapiens	0-5
32768481-11	2020	Our data suggest that Trop2+/P16- may be a valuable prognostic marker for OSCC and that Trop2 inhibits P16 expression and induces S phase by promoting intracellular calcium release in OSCC.	Calcium	165-172	tumor associated calcium signal transducer 2	Homo sapiens	88-93
33196706-1	2020	Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of a humanized anti-Trop-2 IgG antibody conjugated via a hydrolysable linker to SN-38, the topoisomerase I-inhibitory active component of irinotecan.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	86-92
32761920-3	2020	We demonstrate that Trop2 is cleaved at Arg87 by a transmembrane serine protease, matriptase.	Serine	65-71	tumor associated calcium signal transducer 2	Homo sapiens	20-25
33019653-6	2020	The antibody-drug conjugates (ADCs) enfortumab vedotin (EV) and sacituzumab govitecan (SG) have demonstrated the ability to provide objective response rates (ORRs) of 44% and 31% in patients with bladder tumor cells that express Nectin-4 and Trop-2, respectively.	vedotin	47-54	tumor associated calcium signal transducer 2	Homo sapiens	242-248
32669063-5	2020	In RRMM, the annual budget savings of lenalidomide entry were estimated at EGP-(-1,103,969, -3,362,793 and -5,949,228) at year 1, year 2 and year 3 respectively.	Lenalidomide	38-50	tumor associated calcium signal transducer 2	Homo sapiens	75-82
32946924-2	2020	Sacituzumab govitecan (SG; Trodelvy ) is an antibody-drug conjugate composed of a humanized anti-Trop-2 monoclonal antibody coupled to SN-38 at a high drug:antibody ratio via a unique hydrolyzable linker that delivers SN-38 intracellularly and in the tumor microenvironment.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	97-103
32627901-7	2020	The Sca-1+ luminal cells share molecular features with the human TACSTD2+ luminal cells.	Phenobarbital	11-18	tumor associated calcium signal transducer 2	Homo sapiens	65-72
32627901-7	2020	The Sca-1+ luminal cells share molecular features with the human TACSTD2+ luminal cells.	Phenobarbital	74-81	tumor associated calcium signal transducer 2	Homo sapiens	65-72
30417425-7	2019	In particular, the rate constants corresponding to the repair of 8-OH-G adducts were found to be in the order of 104  M-1 s-1 and are assisted by a water molecule.	Water	148-153	tumor associated calcium signal transducer 2	Homo sapiens	118-125
32206190-0	2020	Correction: Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC).	sacituzumab govitecan	90-98	tumor associated calcium signal transducer 2	Homo sapiens	12-18
32231744-0	2020	miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development.	mir-488	0-7	tumor associated calcium signal transducer 2	Homo sapiens	64-69
32231744-0	2020	miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development.	circ	22-26	tumor associated calcium signal transducer 2	Homo sapiens	64-69
31891442-2	2020	The antibody-drug conjugate (ADC) sacituzumab govitecan (SG) targets trophoblast cell-surface antigen-2 (Trop-2) - a cell-surface glycoprotein highly expressed in many epithelial tumors - and delivers the active metabolite of irinotecan SN-38 to Trop-2-positive tumor cells.	Irinotecan	226-236	tumor associated calcium signal transducer 2	Homo sapiens	105-111
31891442-2	2020	The antibody-drug conjugate (ADC) sacituzumab govitecan (SG) targets trophoblast cell-surface antigen-2 (Trop-2) - a cell-surface glycoprotein highly expressed in many epithelial tumors - and delivers the active metabolite of irinotecan SN-38 to Trop-2-positive tumor cells.	Irinotecan	237-242	tumor associated calcium signal transducer 2	Homo sapiens	105-111
31891442-4	2020	Trop-2 expression was assessed in 143 formalin-fixed-paraffin-embedded tumors and seven primary tumor cell lines by immunohistochemistry and flow cytometry, respectively.	Formaldehyde	38-46	tumor associated calcium signal transducer 2	Homo sapiens	0-6
31891442-4	2020	Trop-2 expression was assessed in 143 formalin-fixed-paraffin-embedded tumors and seven primary tumor cell lines by immunohistochemistry and flow cytometry, respectively.	Paraffin	53-61	tumor associated calcium signal transducer 2	Homo sapiens	0-6
32082489-2	2020	Sacituzumab-govitecan (SG) is a new class of antibody-drug-conjugate (ADC) targeting the human-trophoblast-cell-surface marker (Trop-2) conjugated with the active metabolite of irinotecan (SN-38).	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	128-134
32082489-2	2020	Sacituzumab-govitecan (SG) is a new class of antibody-drug-conjugate (ADC) targeting the human-trophoblast-cell-surface marker (Trop-2) conjugated with the active metabolite of irinotecan (SN-38).	Irinotecan	177-187	tumor associated calcium signal transducer 2	Homo sapiens	128-134
32082489-2	2020	Sacituzumab-govitecan (SG) is a new class of antibody-drug-conjugate (ADC) targeting the human-trophoblast-cell-surface marker (Trop-2) conjugated with the active metabolite of irinotecan (SN-38).	Irinotecan	189-194	tumor associated calcium signal transducer 2	Homo sapiens	128-134
32082489-4	2020	Methods: Trop-2 expression was evaluated in 10 formalin-fixed-paraffined-embedded (FFPE) CS by immunohistochemistry and 9 primary CS cell-lines by flow-cytometry.	Formaldehyde	47-55	tumor associated calcium signal transducer 2	Homo sapiens	9-15
32082489-4	2020	Methods: Trop-2 expression was evaluated in 10 formalin-fixed-paraffined-embedded (FFPE) CS by immunohistochemistry and 9 primary CS cell-lines by flow-cytometry.	paraffined	62-72	tumor associated calcium signal transducer 2	Homo sapiens	9-15
31839338-2	2020	Sacituzumab govitecan (SG) is a novel antibody-drug-conjugate (ADC) targeting trophoblast cell-surface antigen 2 (Trop-2), a transmembrane-calcium-signal-transducer, to deliver SN-38, the active metabolite of irinotecan.	irinotecan	209-219	tumor associated calcium signal transducer 2	Homo sapiens	114-120
31969666-8	2020	Trop-2 positive cell lines were highly sensitive to sacituzumab govitecan in vitro, with IC50 values in the range of 0.18 to 0.26 nM (p = 0.02, and p = 0.04 for CVX-8, and ADX-3, respectively).	methyl 2-acetamido-2,4-dideoxy-xylo-hexopyranoside	172-177	tumor associated calcium signal transducer 2	Homo sapiens	0-6
31196625-5	2019	Mithramycin A, an inhibitor of specificity protein 1 (Sp1) transcription factor, effectively inhibited the expression of Trop-2.	mithramycin A	0-13	tumor associated calcium signal transducer 2	Homo sapiens	121-127
31208270-0	2019	Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan.	Irinotecan	60-65	tumor associated calcium signal transducer 2	Homo sapiens	88-94
31208270-2	2019	SN-38 has been conjugated to a humanized antibody against trophoblast cell surface antigen 2 (TROP-2), which is involved in cancer signaling pathways and has increased expression by many cancer cell types, yielding the ADC sacituzumab govitecan.	Irinotecan	0-5	tumor associated calcium signal transducer 2	Homo sapiens	94-100
31177095-11	2019	In summary, our findings provide evidence that Trop-2 is phosphorylated at Ser-322 by PKCalpha/delta and that this phosphorylation enhances cell motility and decreases claudin-7 localization to cellular borders.	Serine	75-78	tumor associated calcium signal transducer 2	Homo sapiens	47-53
30971541-5	2019	TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases.	Paraffin	86-94	tumor associated calcium signal transducer 2	Homo sapiens	0-6
32529410-1	2020	Sacituzumab govitecan (sacituzumab govitecan-hziy; Trodelvy ) is a Trop-2-directed antibody conjugated to a topoisomerase I inhibitor (SN-38) that is being developed by Immunomedics for the treatment of solid tumours, including breast cancer.	Irinotecan	135-140	tumor associated calcium signal transducer 2	Homo sapiens	67-73
32291857-2	2020	Understanding the catalysis of oxidative reactions by TAML activators of peroxides, i.e. iron(III) complexes of tetraamide macrocyclic ligands, advocated a spectrophotometric procedure for quantifying the catalytic activity of TAMLs for colorless targets ( k II ", M -1 s -1 ), which is incomparably more advantageous in terms of time, cost, energy, and ecology than NMR, HPLC, UPLC, GC-MS and other similar techniques.	taml	54-58	tumor associated calcium signal transducer 2	Homo sapiens	265-274
32291857-2	2020	Understanding the catalysis of oxidative reactions by TAML activators of peroxides, i.e. iron(III) complexes of tetraamide macrocyclic ligands, advocated a spectrophotometric procedure for quantifying the catalytic activity of TAMLs for colorless targets ( k II ", M -1 s -1 ), which is incomparably more advantageous in terms of time, cost, energy, and ecology than NMR, HPLC, UPLC, GC-MS and other similar techniques.	Peroxides	73-82	tumor associated calcium signal transducer 2	Homo sapiens	265-274
32291857-2	2020	Understanding the catalysis of oxidative reactions by TAML activators of peroxides, i.e. iron(III) complexes of tetraamide macrocyclic ligands, advocated a spectrophotometric procedure for quantifying the catalytic activity of TAMLs for colorless targets ( k II ", M -1 s -1 ), which is incomparably more advantageous in terms of time, cost, energy, and ecology than NMR, HPLC, UPLC, GC-MS and other similar techniques.	ferric sulfate	89-98	tumor associated calcium signal transducer 2	Homo sapiens	265-274
32291857-2	2020	Understanding the catalysis of oxidative reactions by TAML activators of peroxides, i.e. iron(III) complexes of tetraamide macrocyclic ligands, advocated a spectrophotometric procedure for quantifying the catalytic activity of TAMLs for colorless targets ( k II ", M -1 s -1 ), which is incomparably more advantageous in terms of time, cost, energy, and ecology than NMR, HPLC, UPLC, GC-MS and other similar techniques.	tetraamide	112-122	tumor associated calcium signal transducer 2	Homo sapiens	265-274
32223649-2	2020	Trop-2, a transmembrane calcium signal transducer, is highly expressed in MBC and plays a role in tumor growth and progression.	Calcium	24-31	tumor associated calcium signal transducer 2	Homo sapiens	0-6
32223649-3	2020	Sacituzumab govitecan (SG) is a novel antibody-drug conjugate comprising an Trop-2 antibody coupled to SN-38, the active metabolite of irinotecan, via a unique hydrolyzable linker.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	76-82
32117765-0	2020	Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38), in Ovarian Cancer.	Irinotecan	163-173	tumor associated calcium signal transducer 2	Homo sapiens	120-126
32117765-0	2020	Preclinical Activity of Sacituzumab Govitecan, an Antibody-Drug Conjugate Targeting Trophoblast Cell-Surface Antigen 2 (Trop-2) Linked to the Active Metabolite of Irinotecan (SN-38), in Ovarian Cancer.	Irinotecan	175-180	tumor associated calcium signal transducer 2	Homo sapiens	120-126
32117765-2	2020	Sacituzumab govitecan (SG) is a novel antibody-drug-conjugate (ADC) targeting trophoblast-antigen-2 (Trop-2), a cell surface glycoprotein highly expressed in many epithelial tumors, to deliver SN-38, the active metabolite of irinotecan.	Irinotecan	193-198	tumor associated calcium signal transducer 2	Homo sapiens	101-107
32117765-2	2020	Sacituzumab govitecan (SG) is a novel antibody-drug-conjugate (ADC) targeting trophoblast-antigen-2 (Trop-2), a cell surface glycoprotein highly expressed in many epithelial tumors, to deliver SN-38, the active metabolite of irinotecan.	Irinotecan	225-235	tumor associated calcium signal transducer 2	Homo sapiens	101-107
32117765-4	2020	Methods: Trop-2 expression was assessed in 90 formalin-fixed-paraffin-embedded tumors and nine primary tumor cell lines by immunohistochemistry (IHC) and flow cytometry, respectively.	Formaldehyde	46-54	tumor associated calcium signal transducer 2	Homo sapiens	9-15
32117765-4	2020	Methods: Trop-2 expression was assessed in 90 formalin-fixed-paraffin-embedded tumors and nine primary tumor cell lines by immunohistochemistry (IHC) and flow cytometry, respectively.	Paraffin	61-69	tumor associated calcium signal transducer 2	Homo sapiens	9-15
31534795-12	2019	A homozygous c.355T > A mutation in exon 1 of the TACSTD2 (M1S1) gene was detected, and alteration of the amino acid (p.Cysl19Ser in NCBI entry NP_002344.2) was observed.	cysl19ser	123-132	tumor associated calcium signal transducer 2	Homo sapiens	62-66
31398063-3	2019	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate targeting Trop-2 expressing cells and selectively delivering SN-38, an active metabolite of irinotecan.	sacituzumab govitecan	23-31	tumor associated calcium signal transducer 2	Homo sapiens	73-79
31177095-2	2019	Trophoblast cell surface antigen 2 (Trop-2) belongs to the family of tumor-associated calcium signal transducer (TACSTD) and is required for the stability of claudin-7 and claudin-1, which are often dysregulated or lost in carcinogenesis.	Calcium	86-93	tumor associated calcium signal transducer 2	Homo sapiens	36-42
30507322-3	2019	This encouraged the clinical development of sacituzumab govitecan (IMMU-132), an antibody-drug conjugate targeting Trop-2, a potential target in epithelial cancer such as TNBC.	sacituzumab govitecan	67-75	tumor associated calcium signal transducer 2	Homo sapiens	115-121
29775755-5	2018	EGP1 had a mutation in the NADH gene of the mitochondrial genome ND4 (m.11778 G > A) that causes Leber"s hereditary optic neuropathy.	NAD	27-31	tumor associated calcium signal transducer 2	Homo sapiens	0-4
30431125-5	2019	MTT assay, BrdU incorporation assay, flow cytometry and Transwell assay were performed to demonstrate that knockdown of TROP2 in glioblastoma cells inhibited cell proliferation and metastasis.	Bromodeoxyuridine	11-15	tumor associated calcium signal transducer 2	Homo sapiens	120-125
30215248-0	2018	DFT Provides Insight into the Additive-Free Conversion of Aqueous Methanol to Dihydrogen Catalyzed by [Ru(trop2dad)]: Importance of the (Electronic) Flexibility of the Diazadiene Moiety.	Methanol	66-74	tumor associated calcium signal transducer 2	Homo sapiens	106-111
30215248-0	2018	DFT Provides Insight into the Additive-Free Conversion of Aqueous Methanol to Dihydrogen Catalyzed by [Ru(trop2dad)]: Importance of the (Electronic) Flexibility of the Diazadiene Moiety.	diazadiene	168-178	tumor associated calcium signal transducer 2	Homo sapiens	106-111
29333575-0	2018	A phase 1, dose-escalation study of PF-06664178, an anti-Trop-2/Aur0101 antibody-drug conjugate in patients with advanced or metastatic solid tumors.	pyrazofurin	36-38	tumor associated calcium signal transducer 2	Homo sapiens	57-63
29333575-2	2018	We conducted a phase 1 dose-finding study of PF-06664178, an antibody-drug conjugate that targets Trop-2 for the selective delivery of the cytotoxic payload Aur0101.	pf-06664178	45-56	tumor associated calcium signal transducer 2	Homo sapiens	98-104
29901071-0	2018	Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells.	Curcumin	0-8	tumor associated calcium signal transducer 2	Homo sapiens	69-74
29901071-6	2018	However, whether Trop2 is involved in curcumin-induced BC cell inhibition remains to be elucidated.	Curcumin	38-46	tumor associated calcium signal transducer 2	Homo sapiens	17-22
29901071-7	2018	The present study hypothesized that Trop2 may be a promising target of curcumin in BC cells.	Curcumin	71-79	tumor associated calcium signal transducer 2	Homo sapiens	36-41
29901071-8	2018	It was found that Trop2 was closely involved in curcumin-induced cell proliferation suppression, mobility inhibition, apoptosis, and cell cycle arrest in BC cells.	Curcumin	48-56	tumor associated calcium signal transducer 2	Homo sapiens	18-23
29901071-9	2018	Curcumin decreased the expression of Trop2 and its downstream target cyclin E1, and increased the level of p27.	Curcumin	0-8	tumor associated calcium signal transducer 2	Homo sapiens	37-42
29901071-10	2018	The overexpression of Trop2 enhanced the oncogenic activity of BC cells, whereas downregulation of the expression of Trop2 suppressed cell proliferation and mobility, increased apoptosis, and sensitized BC cells to curcumin treatment.	Curcumin	215-223	tumor associated calcium signal transducer 2	Homo sapiens	117-122
29901071-11	2018	Therefore, Trop2 may be a promising target of curcumin in BC cells and the inhibition of Trop2 may be an important method for the therapeutic management of patients with BC.	Curcumin	46-54	tumor associated calcium signal transducer 2	Homo sapiens	11-16
30002602-0	2018	TROP2 methylation and expression in tamoxifen-resistant breast cancer.	Tamoxifen	36-45	tumor associated calcium signal transducer 2	Homo sapiens	0-5
29927590-6	2018	A similar range of 1  DKIEs (2.4-2.9) on ( kcat/ KGA, M-1 s-1) was reported for dianion-activated hydride transfer from NADL to glycolaldehyde (GA) [Reyes, A. C.; Amyes, T. L.; Richard, J. P. J.	dianion	80-87	tumor associated calcium signal transducer 2	Homo sapiens	54-61
29927590-6	2018	A similar range of 1  DKIEs (2.4-2.9) on ( kcat/ KGA, M-1 s-1) was reported for dianion-activated hydride transfer from NADL to glycolaldehyde (GA) [Reyes, A. C.; Amyes, T. L.; Richard, J. P. J.	nadl	120-124	tumor associated calcium signal transducer 2	Homo sapiens	54-61
29927590-6	2018	A similar range of 1  DKIEs (2.4-2.9) on ( kcat/ KGA, M-1 s-1) was reported for dianion-activated hydride transfer from NADL to glycolaldehyde (GA) [Reyes, A. C.; Amyes, T. L.; Richard, J. P. J.	glycolaldehyde	128-142	tumor associated calcium signal transducer 2	Homo sapiens	54-61
29927590-6	2018	A similar range of 1  DKIEs (2.4-2.9) on ( kcat/ KGA, M-1 s-1) was reported for dianion-activated hydride transfer from NADL to glycolaldehyde (GA) [Reyes, A. C.; Amyes, T. L.; Richard, J. P. J.	glycolaldehyde	50-52	tumor associated calcium signal transducer 2	Homo sapiens	54-61
29927590-6	2018	A similar range of 1  DKIEs (2.4-2.9) on ( kcat/ KGA, M-1 s-1) was reported for dianion-activated hydride transfer from NADL to glycolaldehyde (GA) [Reyes, A. C.; Amyes, T. L.; Richard, J. P. J.	amyes	163-168	tumor associated calcium signal transducer 2	Homo sapiens	54-61
30002602-8	2018	Knocking down TACSTD2 expression in MCF7 increased proliferation however; re-expressing TACSTD2 in TMX2-28 did not inhibit proliferation, indicating that TACSTD2 re-expression alone was insufficient to explain the decreased proliferation observed after treatment with 5-Aza-dC.	Decitabine	268-276	tumor associated calcium signal transducer 2	Homo sapiens	14-21
29467899-1	2018	High levels of tumor-associated calcium signal transduction protein (TROP)-2 have been demonstrated to be strongly associated with tumor necrosis factor (TNF)-alpha levels in colon cancer.	Calcium	32-39	tumor associated calcium signal transducer 2	Homo sapiens	69-76
29989029-4	2018	When the irinotecan metabolite, SN-38, is conjugated to a humanized anti-TROP-2 antibody (sacituzumab govitecan), it shows potent broad anticancer activity in human cancer xenografts and in patients with advanced triple-negative breast, non-small cell and small-cell lung, as well as urothelial cancers.	Irinotecan	9-19	tumor associated calcium signal transducer 2	Homo sapiens	73-79
29989029-4	2018	When the irinotecan metabolite, SN-38, is conjugated to a humanized anti-TROP-2 antibody (sacituzumab govitecan), it shows potent broad anticancer activity in human cancer xenografts and in patients with advanced triple-negative breast, non-small cell and small-cell lung, as well as urothelial cancers.	Irinotecan	32-37	tumor associated calcium signal transducer 2	Homo sapiens	73-79
29855138-4	2018	Evidence for dissociative as well as degenerate exchange mechanisms is revealed by a linear regression analysis of the determined exchange rates resulting in rate coefficients of 1131+-11 s-1 (2390+-70 s-1 ) and 108500+-4900 M-1  s-1 (174200+-13900 M-1  s-1 ), respectively, and an affinity constant of 289+-8 M-1 (278+-14 M-1 ) in physiological saline at 298 K (310 K).	Sodium Chloride	346-352	tumor associated calcium signal transducer 2	Homo sapiens	225-233
29855138-4	2018	Evidence for dissociative as well as degenerate exchange mechanisms is revealed by a linear regression analysis of the determined exchange rates resulting in rate coefficients of 1131+-11 s-1 (2390+-70 s-1 ) and 108500+-4900 M-1  s-1 (174200+-13900 M-1  s-1 ), respectively, and an affinity constant of 289+-8 M-1 (278+-14 M-1 ) in physiological saline at 298 K (310 K).	Sodium Chloride	346-352	tumor associated calcium signal transducer 2	Homo sapiens	249-257
29341297-1	2018	Coordination of the diazadiene diolefin ligand (trop2 dad) to ruthenium leads to various complexes of composition [Ru(trop2 dad)(L)].	diazadiene diolefin	20-39	tumor associated calcium signal transducer 2	Homo sapiens	48-53
29341297-1	2018	Coordination of the diazadiene diolefin ligand (trop2 dad) to ruthenium leads to various complexes of composition [Ru(trop2 dad)(L)].	diazadiene diolefin	20-39	tumor associated calcium signal transducer 2	Homo sapiens	118-123
29341297-1	2018	Coordination of the diazadiene diolefin ligand (trop2 dad) to ruthenium leads to various complexes of composition [Ru(trop2 dad)(L)].	Ruthenium	62-71	tumor associated calcium signal transducer 2	Homo sapiens	48-53
29341297-1	2018	Coordination of the diazadiene diolefin ligand (trop2 dad) to ruthenium leads to various complexes of composition [Ru(trop2 dad)(L)].	Ruthenium	62-71	tumor associated calcium signal transducer 2	Homo sapiens	118-123
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	adn3	36-40	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29965981-5	2018	The most promising dyad, (E)-2-(2-(5-methylfuran-2-yl)vinyl)naphtho[1,2-d]oxazole, FN-6, shows outstanding reactivity and sensitivity: it traps singlet oxygen with a rate constant (5,8 +- 0.1) x 1(07) M-1 s-1 and its fluorescence increases by a factor of 500 upon reaction.	(e)-2-(2-(5-methylfuran-2-yl)vinyl)naphtho[1,2-d]oxazole	25-81	tumor associated calcium signal transducer 2	Homo sapiens	201-208
29965981-5	2018	The most promising dyad, (E)-2-(2-(5-methylfuran-2-yl)vinyl)naphtho[1,2-d]oxazole, FN-6, shows outstanding reactivity and sensitivity: it traps singlet oxygen with a rate constant (5,8 +- 0.1) x 1(07) M-1 s-1 and its fluorescence increases by a factor of 500 upon reaction.	Singlet Oxygen	144-158	tumor associated calcium signal transducer 2	Homo sapiens	201-208
29055700-6	2018	Confocal microscopic images and flow cytometry analysis demonstrated that DOX-ST-NPs were selectively taken up by MDA-MB-231 as the representative Trop2-expressing TNBC cells.	Doxorubicin	74-77	tumor associated calcium signal transducer 2	Homo sapiens	147-152
29055700-7	2018	Consequently, DOX-ST-NPs exhibited higher toxicity to Trop2-positive MDA-MB-231 cancer cells, compared to DOX-loaded control nanoparticles without the disulfide bond or anti-Trop2 antibody.	Doxorubicin	14-17	tumor associated calcium signal transducer 2	Homo sapiens	54-59
29055700-7	2018	Consequently, DOX-ST-NPs exhibited higher toxicity to Trop2-positive MDA-MB-231 cancer cells, compared to DOX-loaded control nanoparticles without the disulfide bond or anti-Trop2 antibody.	Doxorubicin	14-17	tumor associated calcium signal transducer 2	Homo sapiens	174-179
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	Diazomethane	43-55	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	phosphaalkyne	63-76	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	diazadiene	120-130	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	dad	132-135	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	(formal) nitrene	186-202	tumor associated calcium signal transducer 2	Homo sapiens	151-156
29341297-6	2018	Most notable are the reactions with AdN3 , diazomethane, and a phosphaalkyne leading to scission of the C-C bond of the diazadiene (dad) moiety of the trop2 dad ligand, resulting in net (formal) nitrene, carbene, or P C insertion in the dad C-C bond, respectively.	carbene	204-211	tumor associated calcium signal transducer 2	Homo sapiens	151-156
28679770-1	2017	Purpose: We evaluated a Trop-2-targeting antibody conjugated with SN-38 in metastatic small cell lung cancer (mSCLC) patients.Experimental Design: Sacituzumab govitecan was studied in patients with pretreated (median, 2; range, 1-7) mSCLC who received either 8 or 10 mg/kg i.v.	Irinotecan	66-71	tumor associated calcium signal transducer 2	Homo sapiens	24-30
28548889-0	2017	Therapy of Advanced Non-Small-Cell Lung Cancer With an SN-38-Anti-Trop-2 Drug Conjugate, Sacituzumab Govitecan.	Irinotecan	55-60	tumor associated calcium signal transducer 2	Homo sapiens	66-72
28558150-0	2017	Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics.	sacituzumab govitecan	23-31	tumor associated calcium signal transducer 2	Homo sapiens	42-48
28548889-2	2017	We studied sacituzumab govitecan (IMMU-132), a Trop-2 ADC, for the targeting of SN-38.	Irinotecan	80-85	tumor associated calcium signal transducer 2	Homo sapiens	47-53
28291390-0	2017	Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer.	sacituzumab govitecan	82-90	tumor associated calcium signal transducer 2	Homo sapiens	28-34
29060810-6	2017	The NFB group revealed increased DMN functional connectivity after training to the cortical and subcortical sensory/motor areas (M1/S1 and caudate nucleus, respectively), which may be associated with sensorimotor processing of learning in the resting state.	phosphoric acid	4-7	tumor associated calcium signal transducer 2	Homo sapiens	129-134
28291390-2	2017	Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan.	Irinotecan	96-101	tumor associated calcium signal transducer 2	Homo sapiens	59-65
28291390-2	2017	Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan.	Irinotecan	128-138	tumor associated calcium signal transducer 2	Homo sapiens	59-65
28164405-1	2017	A family of cobalt complexes bearing the trop2 NH [bis(5-H-dibenzo[a,d]cyclohepten-5-yl)-amine] and 2,2"-bpy (2,2"-bipyridine) chelate ligands were prepared and fully characterized.	Cobalt	12-18	tumor associated calcium signal transducer 2	Homo sapiens	41-46
28164405-4	2017	Structural data, DFT calculations, and reactivity toward H-abstraction indicate a slightly higher contribution of the aminyl radical form to the ground state of [Co(trop2 N)(bpy)]+ .	Ammonia	118-132	tumor associated calcium signal transducer 2	Homo sapiens	165-170
28164405-4	2017	Structural data, DFT calculations, and reactivity toward H-abstraction indicate a slightly higher contribution of the aminyl radical form to the ground state of [Co(trop2 N)(bpy)]+ .	2,2'-Dipyridyl	174-178	tumor associated calcium signal transducer 2	Homo sapiens	165-170
28164405-5	2017	The results described here complete the series of Group 9 metal aminyl radical complexes bearing the diolefin amine ligand trop2 NH.	metal aminyl radical	58-78	tumor associated calcium signal transducer 2	Homo sapiens	123-128
28164405-5	2017	The results described here complete the series of Group 9 metal aminyl radical complexes bearing the diolefin amine ligand trop2 NH.	diolefin amine	101-115	tumor associated calcium signal transducer 2	Homo sapiens	123-128
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Alkadienes	23-31	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Ruthenium	32-41	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Hydrogen	144-146	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Formaldehyde	152-164	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28452367-2	2017	Herein, we report that diolefin-ruthenium complexes containing the chemically and redox non-innocent ligand trop2dad catalyse the production of H2 from formaldehyde and water in the presence of a base.	Water	169-174	tumor associated calcium signal transducer 2	Homo sapiens	108-113
28938585-8	2017	Significant miR-125b down-regulation was associated with a significant increase in Trop-2 protein levels in BC tissue and correlated with disease severity.	mir-125b	12-20	tumor associated calcium signal transducer 2	Homo sapiens	83-89
28938585-9	2017	In vitro analysis confirmed the role of miR-125b in down-modulation of Trop-2 protein levels and showed that Trop-2/miR-125b axis affects cellular proliferation in bladder tissue.	mir-125b	40-48	tumor associated calcium signal transducer 2	Homo sapiens	71-77
26923841-5	2016	The results show that benzoquinone can efficiently quench the fluorescence of pyranine with dynamic quenching rate constants in the order of 1010 M-1 s-1 , suggesting that the pyranine can act as a good electron donor for photoinduced electron transfer in artificial photosynthesis and organic solar cells.	quinone	22-34	tumor associated calcium signal transducer 2	Homo sapiens	146-153
28345466-7	2017	By screening the trop2-related signaling pathways, we observed that excessive angiogenesis was correlated with activation of ERK1/2 signaling pathway, and ERK1/2 inhibitor (U0126) could suppress the tubular formation ability induced by trop2 expression.	U 0126	173-178	tumor associated calcium signal transducer 2	Homo sapiens	17-22
28345466-7	2017	By screening the trop2-related signaling pathways, we observed that excessive angiogenesis was correlated with activation of ERK1/2 signaling pathway, and ERK1/2 inhibitor (U0126) could suppress the tubular formation ability induced by trop2 expression.	U 0126	173-178	tumor associated calcium signal transducer 2	Homo sapiens	236-241
27793919-3	2016	MATERIALS AND METHODS: Two mAbs against tumor-associated calcium signal transducer 2 (TACSTD2/TROP2), AR47A6.4.2 and Pr1E11, were used.	Calcium	57-64	tumor associated calcium signal transducer 2	Homo sapiens	86-93
27793919-3	2016	MATERIALS AND METHODS: Two mAbs against tumor-associated calcium signal transducer 2 (TACSTD2/TROP2), AR47A6.4.2 and Pr1E11, were used.	Calcium	57-64	tumor associated calcium signal transducer 2	Homo sapiens	94-99
26923841-5	2016	The results show that benzoquinone can efficiently quench the fluorescence of pyranine with dynamic quenching rate constants in the order of 1010 M-1 s-1 , suggesting that the pyranine can act as a good electron donor for photoinduced electron transfer in artificial photosynthesis and organic solar cells.	pyranine	78-86	tumor associated calcium signal transducer 2	Homo sapiens	146-153
26923841-5	2016	The results show that benzoquinone can efficiently quench the fluorescence of pyranine with dynamic quenching rate constants in the order of 1010 M-1 s-1 , suggesting that the pyranine can act as a good electron donor for photoinduced electron transfer in artificial photosynthesis and organic solar cells.	pyranine	176-184	tumor associated calcium signal transducer 2	Homo sapiens	146-153
27283984-5	2016	Consistent with a tumor-initiating role, TROP2high cells from androgen-sensitive prostate cancer cell lines displayed an enhanced ability to re-grow in culture following treatment with taxane-based chemotherapy with or without androgen blockade.	taxane	185-191	tumor associated calcium signal transducer 2	Homo sapiens	41-46
27311870-12	2016	In conclusion, TROP-2 membranous staining is a very sensitive and specific marker for PTC cv, PTC tcv, and mPTC, with high overall specificity for PTC.	TCVS	98-101	tumor associated calcium signal transducer 2	Homo sapiens	15-21
27311870-12	2016	In conclusion, TROP-2 membranous staining is a very sensitive and specific marker for PTC cv, PTC tcv, and mPTC, with high overall specificity for PTC.	MPTC	107-111	tumor associated calcium signal transducer 2	Homo sapiens	15-21
27207776-0	2016	Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers.	sacituzumab govitecan	32-40	tumor associated calcium signal transducer 2	Homo sapiens	50-56
27207776-0	2016	Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers.	Irinotecan	79-84	tumor associated calcium signal transducer 2	Homo sapiens	50-56
27207776-0	2016	Combining ABCG2 Inhibitors with IMMU-132, an Anti-Trop-2 Antibody Conjugate of SN-38, Overcomes Resistance to SN-38 in Breast and Gastric Cancers.	Irinotecan	110-115	tumor associated calcium signal transducer 2	Homo sapiens	50-56
27207776-1	2016	Sacituzumab govitecan (IMMU-132), an SN-38-conjugated antibody-drug conjugate, is showing promising therapeutic results in a phase I/II trial of patients with advanced Trop-2-expressing, metastatic, solid cancers.	sacituzumab govitecan	23-31	tumor associated calcium signal transducer 2	Homo sapiens	168-174
27283984-6	2016	TROP2 down-regulation in these cells reduced their ability to recur after treatment with docetaxel, in the presence or absence of flutamide.	Docetaxel	89-98	tumor associated calcium signal transducer 2	Homo sapiens	0-5
27283984-6	2016	TROP2 down-regulation in these cells reduced their ability to recur after treatment with docetaxel, in the presence or absence of flutamide.	Flutamide	130-139	tumor associated calcium signal transducer 2	Homo sapiens	0-5
26481593-13	2016	This study also identifies a strong role for TROP-2 in separating PTC from BTN.	Biotin	75-78	tumor associated calcium signal transducer 2	Homo sapiens	45-51
27050150-3	2016	Then a novel anti-Trop2 Fab antibody was conjugated with Doxorubicin (DOX) to form Trop2Fab-DOX, an antibody-drug conjugate.	Doxorubicin	57-68	tumor associated calcium signal transducer 2	Homo sapiens	18-23
27050150-3	2016	Then a novel anti-Trop2 Fab antibody was conjugated with Doxorubicin (DOX) to form Trop2Fab-DOX, an antibody-drug conjugate.	Doxorubicin	70-73	tumor associated calcium signal transducer 2	Homo sapiens	18-23
27050150-3	2016	Then a novel anti-Trop2 Fab antibody was conjugated with Doxorubicin (DOX) to form Trop2Fab-DOX, an antibody-drug conjugate.	Doxorubicin	92-95	tumor associated calcium signal transducer 2	Homo sapiens	18-23
27050150-7	2016	Trop2Fab-DOX can bind to the Trop2-expressing PC cells and provide an improved releasing type of DOX.	Doxorubicin	9-12	tumor associated calcium signal transducer 2	Homo sapiens	0-5
27050150-7	2016	Trop2Fab-DOX can bind to the Trop2-expressing PC cells and provide an improved releasing type of DOX.	Doxorubicin	97-100	tumor associated calcium signal transducer 2	Homo sapiens	0-5
26541586-4	2016	This antibody-drug conjugate comprises the active metabolite of irinotecan, SN-38, conjugated to an anti-Trop-2 antibody.	Irinotecan	64-74	tumor associated calcium signal transducer 2	Homo sapiens	105-111
26541586-4	2016	This antibody-drug conjugate comprises the active metabolite of irinotecan, SN-38, conjugated to an anti-Trop-2 antibody.	Irinotecan	76-81	tumor associated calcium signal transducer 2	Homo sapiens	105-111
26577300-1	2016	A phase II study indicates that sacituzumab govitecan (IMMU-132), a Trop-2-specific antibody linked to the irinotecan metabolite SN-38, prolongs the progression-free survival of patients with advanced triple-negative breast cancer.	sacituzumab govitecan	55-63	tumor associated calcium signal transducer 2	Homo sapiens	68-74
26577300-1	2016	A phase II study indicates that sacituzumab govitecan (IMMU-132), a Trop-2-specific antibody linked to the irinotecan metabolite SN-38, prolongs the progression-free survival of patients with advanced triple-negative breast cancer.	Irinotecan	107-117	tumor associated calcium signal transducer 2	Homo sapiens	68-74
26577300-1	2016	A phase II study indicates that sacituzumab govitecan (IMMU-132), a Trop-2-specific antibody linked to the irinotecan metabolite SN-38, prolongs the progression-free survival of patients with advanced triple-negative breast cancer.	Irinotecan	129-134	tumor associated calcium signal transducer 2	Homo sapiens	68-74
25202389-6	2014	The present study therefore aimed to retrospectively investigate TACSTD2 protein expression by immunohistochemistry on paraffin-embedded primary tumor tissue samples from a series of consecutive SACC patients (n=81).	Paraffin	119-127	tumor associated calcium signal transducer 2	Homo sapiens	65-72
26101915-0	2015	Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC).	sacituzumab govitecan	78-86	tumor associated calcium signal transducer 2	Homo sapiens	0-6
26101915-2	2015	The rational development of IMMU-132 represents a paradigm shift as an ADC that binds a well-known moderately-cytotoxic drug, SN-38, to the anti-Trop-2 antibody.	Irinotecan	126-131	tumor associated calcium signal transducer 2	Homo sapiens	145-151
25817572-6	2015	The resulting alternative TROP2 cleavage product remains membrane associated via a disulphide bond, but is released in microvesicles with an average size of 107nm.	disulphide	83-93	tumor associated calcium signal transducer 2	Homo sapiens	26-31
25981199-3	2015	We propose that Trop2 function is modulated by phosphorylation of a specific serine residue within this cytosolic region (Ser303), and by proximity effects exerted on the cytosolic tail by Trop2 dimerization.	Serine	77-83	tumor associated calcium signal transducer 2	Homo sapiens	16-21
25944802-0	2015	First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors.	Irinotecan	53-58	tumor associated calcium signal transducer 2	Homo sapiens	37-43
25944802-1	2015	PURPOSE: Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2, a surface glycoprotein expressed on many epithelial tumors, for delivery of SN-38, the active metabolite of irinotecan.	sacituzumab govitecan	32-40	tumor associated calcium signal transducer 2	Homo sapiens	88-94
25944802-1	2015	PURPOSE: Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2, a surface glycoprotein expressed on many epithelial tumors, for delivery of SN-38, the active metabolite of irinotecan.	Irinotecan	172-177	tumor associated calcium signal transducer 2	Homo sapiens	88-94
25944802-1	2015	PURPOSE: Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2, a surface glycoprotein expressed on many epithelial tumors, for delivery of SN-38, the active metabolite of irinotecan.	Irinotecan	204-214	tumor associated calcium signal transducer 2	Homo sapiens	88-94
25765487-5	2015	Here the syntheses and properties of bimetallic complexes [MFe(I) (trop2 dae)(solv)] (M=Na, solv=3 thf; M=Li, solv=2 Et2 O; trop=5H-dibenzo[a,d]cyclo-hepten-5-yl, dae=(N-CH2 -CH2 -N) with a d(7) Fe low-spin valence-electron configuration are reported.	o,p-dinitrophenyl aminoethyldiphosphate-beryllium trifluoride	73-76	tumor associated calcium signal transducer 2	Homo sapiens	67-72
25765487-5	2015	Here the syntheses and properties of bimetallic complexes [MFe(I) (trop2 dae)(solv)] (M=Na, solv=3 thf; M=Li, solv=2 Et2 O; trop=5H-dibenzo[a,d]cyclo-hepten-5-yl, dae=(N-CH2 -CH2 -N) with a d(7) Fe low-spin valence-electron configuration are reported.	Iron	60-62	tumor associated calcium signal transducer 2	Homo sapiens	67-72
24824621-1	2014	Trop-2 is a calcium signal transducer that drives tumor growth.	Calcium	12-19	tumor associated calcium signal transducer 2	Homo sapiens	0-6
25102337-10	2014	gammaH2AX assay results revealed higher occurrences of DNA-DSBs with anti-TROP2 conjugated HGNs plus laser radiation as compared to treatment with laser alone.	gammah2ax	0-9	tumor associated calcium signal transducer 2	Homo sapiens	74-79
22562244-5	2013	TROP2 upregulation was shown to subsequently drive the expression and activation of CREB1 (cyclic AMP-responsive-element binding protein), Jun, NF-kappaB, Rb, STAT1 and STAT3 through induction of the cyclin D1 and ERK (extracellular signal regulated kinase)/MEK (MAPK/ERK kinase) pathways.	Cyclic AMP	91-101	tumor associated calcium signal transducer 2	Homo sapiens	0-5
24086649-8	2013	Furthermore, the inhibition of TROP2 expression in cervical cancer cell lines enhances sensitivity to cisplatin.	Cisplatin	102-111	tumor associated calcium signal transducer 2	Homo sapiens	31-36
24651436-1	2014	Tumor-associated calcium signal transducer 2 (TACSTD2), a calcium signal transducer, is universally expressed in stratified squamous epithelia of many organs, including skin, esophagus and cervix.	Calcium	17-24	tumor associated calcium signal transducer 2	Homo sapiens	46-53
23511424-5	2013	Isolation and characterization of the ruthenium complexes from these reactions suggested a mechanistic scenario in which the trop2dad ligand behaves as a chemically "non-innocent" co-operative ligand.	Ruthenium	38-47	tumor associated calcium signal transducer 2	Homo sapiens	125-130
22349828-1	2013	Trop-2 is a calcium signal transducer that is associated with transformed cell growth in experimental systems.	Calcium	12-19	tumor associated calcium signal transducer 2	Homo sapiens	0-6
23151048-4	2012	METHODS: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC.	Formaldehyde	89-97	tumor associated calcium signal transducer 2	Homo sapiens	9-15
22539223-7	2012	RESULTS: CG-5 and glucose deprivation upregulated the expression of DNA methylation-silenced tumor suppressor genes, including GADD45a, GADD45b, IGFBP3, LAMB3, BASP1, GPX3, and GSTP1, but also downregulated methylated tumor/invasion-promoting genes, including CD44, S100A4, and TACSTD2.	Glucose	18-25	tumor associated calcium signal transducer 2	Homo sapiens	278-285
23151048-4	2012	METHODS: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC.	Paraffin	104-112	tumor associated calcium signal transducer 2	Homo sapiens	9-15
22419550-3	2012	The lack of expression could be due to either the loss of heterozygosity (LOH) or hypermethylation of the CpG island DNA of TROP2 upstream promoter region as confirmed by bisulphite sequencing and methylation-specific (MS) polymerase chain reaction (PCR).	hydrogen sulfite	171-181	tumor associated calcium signal transducer 2	Homo sapiens	124-129
22419550-4	2012	5-Aza-2"-deoxycytidine treatment on lung cancer cell (CL) lines, CL1-5 and A549, reversed the hypermethylation status and elevated both TROP2 mRNA and protein expression levels.	Decitabine	0-22	tumor associated calcium signal transducer 2	Homo sapiens	136-141
22482828-1	2012	BACKGROUND: The tumor-associated calcium signal transducer (TACSTD) genes, originally designated epithelial cell adhesion molecule (EpCAM) and TROP2, represent true oncogenes.	Calcium	33-40	tumor associated calcium signal transducer 2	Homo sapiens	143-148
22536613-0	2004	(111)In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Pentetic Acid	8-43	tumor associated calcium signal transducer 2	Homo sapiens	49-74
22536613-0	2004	(111)In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Pentetic Acid	8-43	tumor associated calcium signal transducer 2	Homo sapiens	110-135
22536613-0	2004	(111)In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Pentetic Acid	8-43	tumor associated calcium signal transducer 2	Homo sapiens	137-142
22536613-0	2004	(111)In-Diethylenetriamine pentaacetic acid-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Pentetic Acid	8-43	tumor associated calcium signal transducer 2	Homo sapiens	158-163
22536613-3	2004	EGP-1 activates intracellular calcium mobilization (2) and protein kinase C (3) after binding with RS7.	Calcium	30-37	tumor associated calcium signal transducer 2	Homo sapiens	0-5
22536615-0	2004	(89)Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Deferoxamine	7-22	tumor associated calcium signal transducer 2	Homo sapiens	28-53
22536615-0	2004	(89)Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Deferoxamine	7-22	tumor associated calcium signal transducer 2	Homo sapiens	89-114
22536615-0	2004	(89)Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Deferoxamine	7-22	tumor associated calcium signal transducer 2	Homo sapiens	116-121
22536615-0	2004	(89)Zr-Desferrioxamine-anti-epithelial glycoprotein-1 hRS7 humanized monoclonal antibody Epithelial glycoprotein-1 (EGP-1, also known as TROP2) is a transmembrane glycoprotein (46 kDa) identified with murine IgG1 monoclonal antibody (mAb) RS7 raised against human non-small cell lung carcinoma (1).	Deferoxamine	7-22	tumor associated calcium signal transducer 2	Homo sapiens	137-142
22536615-3	2004	EGP-1 activates intracellular calcium mobilization (2) and protein kinase C (3) after binding with RS7.	Calcium	30-37	tumor associated calcium signal transducer 2	Homo sapiens	0-5
22075385-2	2011	MATERIALS AND METHODS: Trop-2 expression was evaluated by immunohistochemistry (IHC) in paraffin-embedded tumor tissues, by real-time polymerase-chain-reaction (RT-PCR) and flow-cytometry in cell lines.	Paraffin	88-96	tumor associated calcium signal transducer 2	Homo sapiens	23-29
20060709-5	2010	Trop-2 protein expression was then examined by immunohistochemistry in matched formalin-fixed paraffin-embedded EOC samples and in 13 normal ovaries.	Formaldehyde	79-87	tumor associated calcium signal transducer 2	Homo sapiens	0-6
21372224-0	2011	Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys.	Irinotecan	26-31	tumor associated calcium signal transducer 2	Homo sapiens	15-21
21372224-1	2011	PURPOSE: Evaluate the efficacy of an SN-38-anti-Trop-2 antibody-drug conjugate (ADC) against several human solid tumor types, and to assess its tolerability in mice and monkeys, the latter with tissue cross-reactivity to hRS7 similar to humans.	Irinotecan	37-42	tumor associated calcium signal transducer 2	Homo sapiens	48-54
21372224-2	2011	EXPERIMENTAL DESIGN: Two SN-38 derivatives, CL2-SN-38 and CL2A-SN-38, were conjugated to the anti-Trop-2-humanized antibody, hRS7.	Irinotecan	25-30	tumor associated calcium signal transducer 2	Homo sapiens	98-104
21372224-2	2011	EXPERIMENTAL DESIGN: Two SN-38 derivatives, CL2-SN-38 and CL2A-SN-38, were conjugated to the anti-Trop-2-humanized antibody, hRS7.	CL2A-SN-38	58-68	tumor associated calcium signal transducer 2	Homo sapiens	98-104
21372224-11	2011	CONCLUSIONS: The anti-Trop-2 hRS7-CL2A-SN-38 ADC provides significant and specific antitumor effects against a range of human solid tumor types.	Irinotecan	39-44	tumor associated calcium signal transducer 2	Homo sapiens	22-28
20682974-0	2010	(-)-Epigallocatechin-3-gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells.	epigallocatechin gallate	0-30	tumor associated calcium signal transducer 2	Homo sapiens	128-133
20682974-0	2010	(-)-Epigallocatechin-3-gallate (EGCG) post-transcriptionally and post-translationally suppresses the cell proliferative protein TROP2 in human colorectal cancer cells.	epigallocatechin gallate	32-36	tumor associated calcium signal transducer 2	Homo sapiens	128-133
20682974-2	2010	The main aim of this study was to examine the effect of green tea catechins (namely, (-)-epigallocatechin-3-gallate; EGCG) on TROP-2 expression.	Catechin	66-75	tumor associated calcium signal transducer 2	Homo sapiens	126-132
20682974-2	2010	The main aim of this study was to examine the effect of green tea catechins (namely, (-)-epigallocatechin-3-gallate; EGCG) on TROP-2 expression.	epigallocatechin gallate	85-115	tumor associated calcium signal transducer 2	Homo sapiens	126-132
20682974-2	2010	The main aim of this study was to examine the effect of green tea catechins (namely, (-)-epigallocatechin-3-gallate; EGCG) on TROP-2 expression.	epigallocatechin gallate	117-121	tumor associated calcium signal transducer 2	Homo sapiens	126-132
20682974-5	2010	In SW480 cells, EGCG affected the post-transcriptional processing of the TROP-2 mRNA, as this was quickly and specifically degraded in the presence of EGCG.	epigallocatechin gallate	16-20	tumor associated calcium signal transducer 2	Homo sapiens	73-79
20682974-5	2010	In SW480 cells, EGCG affected the post-transcriptional processing of the TROP-2 mRNA, as this was quickly and specifically degraded in the presence of EGCG.	epigallocatechin gallate	151-155	tumor associated calcium signal transducer 2	Homo sapiens	73-79
20682974-6	2010	In HCT-116 cells, EGCG affected TROP-2 expression at the post-translational level.	epigallocatechin gallate	18-22	tumor associated calcium signal transducer 2	Homo sapiens	32-38
20060709-5	2010	Trop-2 protein expression was then examined by immunohistochemistry in matched formalin-fixed paraffin-embedded EOC samples and in 13 normal ovaries.	Paraffin	94-102	tumor associated calcium signal transducer 2	Homo sapiens	0-6
16848556-1	2006	Phenolic compounds present in beer were shown by fluorescence spectroscopy and laser flash photolysis to deactivate both singlet- and triplet-excited states of riboflavin with bimolecular rate constants close to the diffusion control ranging from 2.8x10(9) to 1.1x10(10) M-1 s-1 and from 1.1x10(9) to 2.6x10(9) M-1 s-1, respectively.	Riboflavin	160-170	tumor associated calcium signal transducer 2	Homo sapiens	271-278
18084248-6	2008	TROP2 expression was examined by immunohistochemistry in a series of 90 patients on a tissue microarray of paraffin-embedded specimens.	Paraffin	107-115	tumor associated calcium signal transducer 2	Homo sapiens	0-5
18813308-4	2008	TROP2 antigen expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumour tissue samples from a series (n=197) of consecutive patients with pancreatic adenocarcinoma.	Paraffin	85-93	tumor associated calcium signal transducer 2	Homo sapiens	0-5
17982676-7	2007	Alterations in gene expression in 5-FU-treated TP53-depleted HCT116 cultures confirmed previously-reported TP53 target genes and suggested potentially novel TP53 target genes (e.g. APOBEC3C, BIRC3, JMJD2B, LAMP3, MYO1E, PRRG1, SULF2, TACSTD2, TncRNA, ZFYVE20) that may play a role in mediating the 5-FU-induced DNA damage response in TP53-proficient cells.	Fluorouracil	34-38	tumor associated calcium signal transducer 2	Homo sapiens	234-241
16848556-1	2006	Phenolic compounds present in beer were shown by fluorescence spectroscopy and laser flash photolysis to deactivate both singlet- and triplet-excited states of riboflavin with bimolecular rate constants close to the diffusion control ranging from 2.8x10(9) to 1.1x10(10) M-1 s-1 and from 1.1x10(9) to 2.6x10(9) M-1 s-1, respectively.	Riboflavin	160-170	tumor associated calcium signal transducer 2	Homo sapiens	311-318
16707602-3	2006	TROP2 is known as a calcium signal transducer and is highly expressed in several types of tumors.	Calcium	20-27	tumor associated calcium signal transducer 2	Homo sapiens	0-5
15386348-2	2004	One of the clones identified was TROP2, which is known as calcium signal transducer.	Calcium	58-65	tumor associated calcium signal transducer 2	Homo sapiens	33-38
15924389-7	2005	The measured association rates for both SYTOX Orange and PicoGreen stains intercalating into dsDNA were on the order of 10(8) M-1 s-1, suggesting a diffusion-controlled process.	SYTOX Orange dye	40-52	tumor associated calcium signal transducer 2	Homo sapiens	126-133
14639618-8	2004	The colorimetric MTT assay was then used to measure dose-dependent growth inhibition from single modality chemotherapy (doxorubicin, carboplatin, paclitaxel or topotecan) or radioimmunotherapy (90Y-RS-7 IgG anti-EGP1).	monooxyethylene trimethylolpropane tristearate	17-20	tumor associated calcium signal transducer 2	Homo sapiens	212-216
15355929-0	2004	In vitro toxicity of A-431 carcinoma cells with antibodies to epidermal growth factor receptor and epithelial glycoprotein-1 conjugated to radionuclides emitting low-energy electrons.	Radioisotopes	139-152	tumor associated calcium signal transducer 2	Homo sapiens	99-124
15355929-4	2004	EXPERIMENTAL DESIGN: The Abs tested were anti-epidermal growth factor receptor and anti-epithelial glycoprotein-1, conjugated to indium-111 or iodine-125, which emit low-energy Auger and conversion electrons.	Indium-111	129-139	tumor associated calcium signal transducer 2	Homo sapiens	88-113
15355929-4	2004	EXPERIMENTAL DESIGN: The Abs tested were anti-epidermal growth factor receptor and anti-epithelial glycoprotein-1, conjugated to indium-111 or iodine-125, which emit low-energy Auger and conversion electrons.	Iodine-125	143-153	tumor associated calcium signal transducer 2	Homo sapiens	88-113
10989614-6	2000	Pyrylretinol (1) also quenches the BSA intrinsic fluorescence with the quenching rate constant of 1.67 x 10(13) M-1 s-1 and the value is lower than that obtained for retinol (4.06 x 10(13) M-1 s-1).	pyrylretinol	0-12	tumor associated calcium signal transducer 2	Homo sapiens	112-119
11182798-3	2001	We evaluated the growth of xenografts of CALU-3 tumors, a non-small cell lung carcinoma, in response to an 8.9-MBq dose of 131I-RS-7-anti-EGP-1 and correlated tumor growth rate with initial tumor pO2 measured by EPR oximetry.	131i-rs-7	123-132	tumor associated calcium signal transducer 2	Homo sapiens	138-143
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Flavonoids	25-35	tumor associated calcium signal transducer 2	Homo sapiens	105-132
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Quercetin	37-46	tumor associated calcium signal transducer 2	Homo sapiens	105-132
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Rutin	51-56	tumor associated calcium signal transducer 2	Homo sapiens	105-132
11697193-4	2001	Also, .UH- is reduced by flavonoids, quercetin and rutin in CTAB micelles at rate constants of 6 x 10(6) M-1s-1 and 1 x 10(6) M-1s-1, respectively.	Cetrimonium	60-64	tumor associated calcium signal transducer 2	Homo sapiens	105-132
10989614-6	2000	Pyrylretinol (1) also quenches the BSA intrinsic fluorescence with the quenching rate constant of 1.67 x 10(13) M-1 s-1 and the value is lower than that obtained for retinol (4.06 x 10(13) M-1 s-1).	pyrylretinol	0-12	tumor associated calcium signal transducer 2	Homo sapiens	189-196
10989614-6	2000	Pyrylretinol (1) also quenches the BSA intrinsic fluorescence with the quenching rate constant of 1.67 x 10(13) M-1 s-1 and the value is lower than that obtained for retinol (4.06 x 10(13) M-1 s-1).	Vitamin A	5-12	tumor associated calcium signal transducer 2	Homo sapiens	112-119
10989614-6	2000	Pyrylretinol (1) also quenches the BSA intrinsic fluorescence with the quenching rate constant of 1.67 x 10(13) M-1 s-1 and the value is lower than that obtained for retinol (4.06 x 10(13) M-1 s-1).	Vitamin A	5-12	tumor associated calcium signal transducer 2	Homo sapiens	189-196
10767324-3	2000	Phosphatidylinositol-binding sequences more distantly related to HIKE are present in gelsolin, in the G protein-coupled receptor kinase 4 and in Trop-2.	Phosphatidylinositols	0-20	tumor associated calcium signal transducer 2	Homo sapiens	145-151
10946567-3	2000	Easily oxidized substrates such as tyrosine, tryptophan and guanosine monophosphate react with the 8-methoxypsoralen and several methoxy-substituted coumarin radical cations with rate constants in excess of 2 x 10(9) M-1 s-1.	Tyrosine	35-43	tumor associated calcium signal transducer 2	Homo sapiens	217-224
10946567-3	2000	Easily oxidized substrates such as tyrosine, tryptophan and guanosine monophosphate react with the 8-methoxypsoralen and several methoxy-substituted coumarin radical cations with rate constants in excess of 2 x 10(9) M-1 s-1.	Tryptophan	45-55	tumor associated calcium signal transducer 2	Homo sapiens	217-224
10946567-3	2000	Easily oxidized substrates such as tyrosine, tryptophan and guanosine monophosphate react with the 8-methoxypsoralen and several methoxy-substituted coumarin radical cations with rate constants in excess of 2 x 10(9) M-1 s-1.	Guanosine Monophosphate	60-83	tumor associated calcium signal transducer 2	Homo sapiens	217-224
10946567-3	2000	Easily oxidized substrates such as tyrosine, tryptophan and guanosine monophosphate react with the 8-methoxypsoralen and several methoxy-substituted coumarin radical cations with rate constants in excess of 2 x 10(9) M-1 s-1.	Methoxsalen	99-116	tumor associated calcium signal transducer 2	Homo sapiens	217-224
10946567-3	2000	Easily oxidized substrates such as tyrosine, tryptophan and guanosine monophosphate react with the 8-methoxypsoralen and several methoxy-substituted coumarin radical cations with rate constants in excess of 2 x 10(9) M-1 s-1.	methoxy-substituted coumarin	129-157	tumor associated calcium signal transducer 2	Homo sapiens	217-224
10874621-3	2000	Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively.	Ozone	40-45	tumor associated calcium signal transducer 2	Homo sapiens	114-120
10874621-3	2000	Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively.	Simazine	50-58	tumor associated calcium signal transducer 2	Homo sapiens	114-120
10874621-3	2000	Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively.	Hydroxyl Radical	63-79	tumor associated calcium signal transducer 2	Homo sapiens	114-120
10874621-3	2000	Rate constants of the reactions between ozone and simazine and hydroxyl radical and simazine were found to be 8.7 M-1s-1 and 2.1 x 10(9) M-1s-1, respectively.	Simazine	84-92	tumor associated calcium signal transducer 2	Homo sapiens	114-120
9610724-2	1998	The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence.	Serine	51-57	tumor associated calcium signal transducer 2	Homo sapiens	24-30
10515078-5	1999	By assuming that in an inhibitor-free system the disappearance of radicals takes place via their combination process as well as by their interaction with luminol and/or with luminol-derived species, numerical integration yields a calculated curve of radical concentration versus time in fair agreement with experimental data and a rate-constant value for the combination of radicals of approximately 10(6) M-1 s-1, supporting literature findings according to which primarily superoxide anion radicals are formed.	Luminol	174-181	tumor associated calcium signal transducer 2	Homo sapiens	406-413
9829999-6	1998	The halomethyl ketone benzyloxycarbonyl-VAD fluoromethyl ketone is a broad specificity irreversible caspase inhibitor, with second-order inactivation rates that range from 2.9 x 10(2) M-1 s-1 for caspase-2 to 2.8 x 10(5) M-1 s-1 for caspase-1.	halomethyl ketone	4-21	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9829999-6	1998	The halomethyl ketone benzyloxycarbonyl-VAD fluoromethyl ketone is a broad specificity irreversible caspase inhibitor, with second-order inactivation rates that range from 2.9 x 10(2) M-1 s-1 for caspase-2 to 2.8 x 10(5) M-1 s-1 for caspase-1.	halomethyl ketone	4-21	tumor associated calcium signal transducer 2	Homo sapiens	221-228
9829999-6	1998	The halomethyl ketone benzyloxycarbonyl-VAD fluoromethyl ketone is a broad specificity irreversible caspase inhibitor, with second-order inactivation rates that range from 2.9 x 10(2) M-1 s-1 for caspase-2 to 2.8 x 10(5) M-1 s-1 for caspase-1.	-vad fluoromethyl ketone	39-63	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9829999-6	1998	The halomethyl ketone benzyloxycarbonyl-VAD fluoromethyl ketone is a broad specificity irreversible caspase inhibitor, with second-order inactivation rates that range from 2.9 x 10(2) M-1 s-1 for caspase-2 to 2.8 x 10(5) M-1 s-1 for caspase-1.	-vad fluoromethyl ketone	39-63	tumor associated calcium signal transducer 2	Homo sapiens	221-228
10049713-5	1999	Simulation based on the mechanism suggested revealed that the likely value for the rate constant of the primary step between luminol and superoxide anion radicals producing luminol radicals is 5x10(2)-1x10(3) M-1s-1.	Luminol	125-132	tumor associated calcium signal transducer 2	Homo sapiens	209-215
10049713-5	1999	Simulation based on the mechanism suggested revealed that the likely value for the rate constant of the primary step between luminol and superoxide anion radicals producing luminol radicals is 5x10(2)-1x10(3) M-1s-1.	Superoxides	137-162	tumor associated calcium signal transducer 2	Homo sapiens	209-215
10049713-5	1999	Simulation based on the mechanism suggested revealed that the likely value for the rate constant of the primary step between luminol and superoxide anion radicals producing luminol radicals is 5x10(2)-1x10(3) M-1s-1.	Luminol	173-180	tumor associated calcium signal transducer 2	Homo sapiens	209-215
9610724-2	1998	The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence.	Tyrosine	62-70	tumor associated calcium signal transducer 2	Homo sapiens	24-30
9610724-2	1998	The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence.	Phosphatidylinositols	99-120	tumor associated calcium signal transducer 2	Homo sapiens	24-30
9610724-4	1998	Using the fluorescent probe Fura-2, we assayed the cytoplasmic calcium levels in human cancer cells stimulated with anti-Trop-2 or control antibodies.	Fura-2	28-34	tumor associated calcium signal transducer 2	Homo sapiens	121-127
9610724-4	1998	Using the fluorescent probe Fura-2, we assayed the cytoplasmic calcium levels in human cancer cells stimulated with anti-Trop-2 or control antibodies.	Calcium	63-70	tumor associated calcium signal transducer 2	Homo sapiens	121-127
9610724-5	1998	Three anti-Trop-2 MAbs, Rs7-7G11, MOv16 and 162-46.2 specifically induced a transient intracellular calcium level increment in up to 40% of the experiments performed.	Calcium	100-107	tumor associated calcium signal transducer 2	Homo sapiens	11-17
9610724-11	1998	Our findings show that Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand.	Calcium	58-65	tumor associated calcium signal transducer 2	Homo sapiens	23-29
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-Nitrosothiols	48-63	tumor associated calcium signal transducer 2	Homo sapiens	145-152
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-Nitrosothiols	48-63	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	Superoxides	83-93	tumor associated calcium signal transducer 2	Homo sapiens	145-152
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	Superoxides	83-93	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-nitrosocysteine	154-171	tumor associated calcium signal transducer 2	Homo sapiens	145-152
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-Nitrosoglutathione	193-213	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-Nitrosothiols	48-62	tumor associated calcium signal transducer 2	Homo sapiens	145-152
9497319-4	1998	Kinetic analysis showed that the degradation of S-nitrosothiols in the presence of superoxide proceeded at second order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathione), respectively, with a stoichiometric ratio of 1 mol of S-nitrosothiol per 2 mol of superoxide.	S-Nitrosothiols	48-62	tumor associated calcium signal transducer 2	Homo sapiens	184-191
9041521-4	1997	Resialylation of gp35/50, by incubation of parasites with T. cruzi trans-sialidase and sialyl lactose, restored the reactivity with mAb 3C9 as well as the affinity for sialic acid specific lectin.	Lactose	94-101	tumor associated calcium signal transducer 2	Homo sapiens	17-24
9462726-1	1998	Trop-2 is a novel calcium signal transducer expressed at high levels by most human carcinomas.	Calcium	18-25	tumor associated calcium signal transducer 2	Homo sapiens	0-6
9453405-6	1998	In RPT cells grown under SHAKE conditions, HSP70 synthesis was detected 1 h after heat stress and decreased below detection by 3 h. In contrast, the uptake of radiolabeled mannose into (glycoprotein) GP62 (Mr 62,000), GP50, and GP38 was observed in control SHAKE cultures and was not further increased after heat stress.	Mannose	172-179	tumor associated calcium signal transducer 2	Homo sapiens	218-222
9540219-4	1998	The rate constants for reaction of 6-chloromelatonin and melatonin with solvated electrons are 4.5 x 10(9) M-1 s-1 and 4.2 x 10(8) M-1 s-1, respectively.	6-chloromelatonin	35-52	tumor associated calcium signal transducer 2	Homo sapiens	107-138
9540219-4	1998	The rate constants for reaction of 6-chloromelatonin and melatonin with solvated electrons are 4.5 x 10(9) M-1 s-1 and 4.2 x 10(8) M-1 s-1, respectively.	Melatonin	43-52	tumor associated calcium signal transducer 2	Homo sapiens	107-138
9540219-5	1998	The reaction rate constants of N3 x with malatonin and chloromelatonin are 9.8 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1, respectively.	malatonin	41-50	tumor associated calcium signal transducer 2	Homo sapiens	87-118
9540219-5	1998	The reaction rate constants of N3 x with malatonin and chloromelatonin are 9.8 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1 and 3.5 x 10(9) M-1 s-1, respectively.	chloromelatonin	55-70	tumor associated calcium signal transducer 2	Homo sapiens	87-118
9378371-2	1997	Kinetic modeling of the experimental data suggests that both peroxynitrous acid and the peroxynitrite anion react with MetSe to form MetSeO with rate constants of 20,460 +/- 440 M-1 s-1 and 200 +/- 170 M-1 s-1, respectively at 25 degrees C. The enthalpy (delta H++) and entropy (delta S++) of activation for the reaction of peroxynitrous acid with MetSe at pH 4.6 are 2.55 +/- 0.08 kcal mol-1 and -30.5 +/- 0.3 cal mol-1 K-1, respectively.	Peroxynitrous Acid	61-79	tumor associated calcium signal transducer 2	Homo sapiens	178-209
9378371-2	1997	Kinetic modeling of the experimental data suggests that both peroxynitrous acid and the peroxynitrite anion react with MetSe to form MetSeO with rate constants of 20,460 +/- 440 M-1 s-1 and 200 +/- 170 M-1 s-1, respectively at 25 degrees C. The enthalpy (delta H++) and entropy (delta S++) of activation for the reaction of peroxynitrous acid with MetSe at pH 4.6 are 2.55 +/- 0.08 kcal mol-1 and -30.5 +/- 0.3 cal mol-1 K-1, respectively.	peroxynitrite anion	88-107	tumor associated calcium signal transducer 2	Homo sapiens	178-209
9378371-2	1997	Kinetic modeling of the experimental data suggests that both peroxynitrous acid and the peroxynitrite anion react with MetSe to form MetSeO with rate constants of 20,460 +/- 440 M-1 s-1 and 200 +/- 170 M-1 s-1, respectively at 25 degrees C. The enthalpy (delta H++) and entropy (delta S++) of activation for the reaction of peroxynitrous acid with MetSe at pH 4.6 are 2.55 +/- 0.08 kcal mol-1 and -30.5 +/- 0.3 cal mol-1 K-1, respectively.	methionine selenoxide	133-139	tumor associated calcium signal transducer 2	Homo sapiens	178-209
9041521-4	1997	Resialylation of gp35/50, by incubation of parasites with T. cruzi trans-sialidase and sialyl lactose, restored the reactivity with mAb 3C9 as well as the affinity for sialic acid specific lectin.	N-Acetylneuraminic Acid	168-179	tumor associated calcium signal transducer 2	Homo sapiens	17-24
9041521-8	1997	Consistent with the results of cell invasion assay, the desialylated parasite preparations, as well as the sialic acid free gp35/50, induced an average elevation in [Ca2+]i significantly higher than that triggered by untreated controls.	N-Acetylneuraminic Acid	107-118	tumor associated calcium signal transducer 2	Homo sapiens	124-131
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Hydroxyl Radical	26-43	tumor associated calcium signal transducer 2	Homo sapiens	142-154
9010598-4	1996	Interestingly, upon binding of a substrate such as laurate, the second order kinetics become monophasic, with a value of 3.5 x 10(6) M-1 s-1, which are similar to the slow rate found in the substrate-free form of the protein.	Laurates	51-58	tumor associated calcium signal transducer 2	Homo sapiens	133-140
8720914-5	1996	The reaction constants with the reactive oxygen species hydroxyl radical and superoxide radical were also calculated and found to be 1.5 x 10(9) M-1s-1 and 8.1 x 10(2) M-1s-1, respectively.	reactive oxygen species hydroxyl radical	32-72	tumor associated calcium signal transducer 2	Homo sapiens	145-151
8720914-5	1996	The reaction constants with the reactive oxygen species hydroxyl radical and superoxide radical were also calculated and found to be 1.5 x 10(9) M-1s-1 and 8.1 x 10(2) M-1s-1, respectively.	reactive oxygen species hydroxyl radical	32-72	tumor associated calcium signal transducer 2	Homo sapiens	168-174
8720914-5	1996	The reaction constants with the reactive oxygen species hydroxyl radical and superoxide radical were also calculated and found to be 1.5 x 10(9) M-1s-1 and 8.1 x 10(2) M-1s-1, respectively.	Superoxides	77-95	tumor associated calcium signal transducer 2	Homo sapiens	145-151
8720914-5	1996	The reaction constants with the reactive oxygen species hydroxyl radical and superoxide radical were also calculated and found to be 1.5 x 10(9) M-1s-1 and 8.1 x 10(2) M-1s-1, respectively.	Superoxides	77-95	tumor associated calcium signal transducer 2	Homo sapiens	168-174
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Hydroxyl Radical	26-43	tumor associated calcium signal transducer 2	Homo sapiens	142-148
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Bromhexine	49-59	tumor associated calcium signal transducer 2	Homo sapiens	142-154
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Bromhexine	49-59	tumor associated calcium signal transducer 2	Homo sapiens	142-148
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Ambroxol	64-72	tumor associated calcium signal transducer 2	Homo sapiens	142-154
8831801-4	1996	The reaction constants of hydroxyl radicals with bromhexine and ambroxol were determined by competition kinetics to be 1.58 +/- 0.15 x 10(10) M-1S-1 and 1.04 +/- 0.1 x 10(10) M-1S-1, respectively.	Ambroxol	64-72	tumor associated calcium signal transducer 2	Homo sapiens	142-148
8831801-5	1996	N-acetyl-L-cysteine also reacted with hydroxyl radicals (1.28 +/- 0.14 x 10(10) M-1S-1) but not with superoxide radical.	Acetylcysteine	0-19	tumor associated calcium signal transducer 2	Homo sapiens	80-86
8831801-5	1996	N-acetyl-L-cysteine also reacted with hydroxyl radicals (1.28 +/- 0.14 x 10(10) M-1S-1) but not with superoxide radical.	Hydroxyl Radical	38-55	tumor associated calcium signal transducer 2	Homo sapiens	80-86
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	22-24	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8789250-1	1995	Melatonin is an excellent free radical scavenger, reacting with tert-butoxyl and cumyloxyl radicals with rate constants of 3.4 x 10(7) and 6.7 x 10(7) M-1s-1, respectively.	Melatonin	0-9	tumor associated calcium signal transducer 2	Homo sapiens	151-157
8789250-1	1995	Melatonin is an excellent free radical scavenger, reacting with tert-butoxyl and cumyloxyl radicals with rate constants of 3.4 x 10(7) and 6.7 x 10(7) M-1s-1, respectively.	tert-butoxyl and	64-80	tumor associated calcium signal transducer 2	Homo sapiens	151-157
8789250-1	1995	Melatonin is an excellent free radical scavenger, reacting with tert-butoxyl and cumyloxyl radicals with rate constants of 3.4 x 10(7) and 6.7 x 10(7) M-1s-1, respectively.	cumyloxyl radicals	81-99	tumor associated calcium signal transducer 2	Homo sapiens	151-157
8789250-2	1995	Reaction with benzophenone triplet occurs with a near-diffusion-controlled rate constant of 7.6 x 10(9) M-1s-1 in acetonitrile and probably involves charge transfer.	benzophenone	14-26	tumor associated calcium signal transducer 2	Homo sapiens	104-110
8789250-2	1995	Reaction with benzophenone triplet occurs with a near-diffusion-controlled rate constant of 7.6 x 10(9) M-1s-1 in acetonitrile and probably involves charge transfer.	acetonitrile	114-126	tumor associated calcium signal transducer 2	Homo sapiens	104-110
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	22-24	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	22-24	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Oxymetazoline	52-66	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Oxymetazoline	52-66	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Oxymetazoline	52-66	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	xylometazoline	101-116	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	xylometazoline	101-116	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	xylometazoline	101-116	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Cimetidine	175-185	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Cimetidine	175-185	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Cimetidine	175-185	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	40-47
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	89-96
8549644-4	1995	Their rate constants (ks = 1.1 x 10(12) M-1 s-1 for oxymethazoline and ks = 4.7 x 10(10) M-1 s-1 for xylomethazoline) exceeded the rate constant of a known powerful scavenger cimetidine (ks = 1.8 x 10(10) M-1 s-1).	Potassium	71-73	tumor associated calcium signal transducer 2	Homo sapiens	89-96
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Methionine	15-25	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7744307-3	1995	The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions.	Dipyridamole	38-50	tumor associated calcium signal transducer 2	Homo sapiens	134-140
7744307-3	1995	The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions.	Dipyridamole	38-50	tumor associated calcium signal transducer 2	Homo sapiens	169-175
7744307-3	1995	The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions.	methyl linoleate peroxyl radicals	56-89	tumor associated calcium signal transducer 2	Homo sapiens	134-140
7744307-3	1995	The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions.	methyl linoleate peroxyl radicals	56-89	tumor associated calcium signal transducer 2	Homo sapiens	169-175
7744307-3	1995	The rate constant for the reaction of dipyridamole with methyl linoleate peroxyl radicals at 37 degrees C was calculated as 2 x 10(6) M-1s-1, in comparison to 1 x 10(6) M-1s-1 of vitamin E under the same conditions.	Vitamin E	179-188	tumor associated calcium signal transducer 2	Homo sapiens	169-175
7635574-0	1995	The epithelial/carcinoma antigen EGP-1, recognized by monoclonal antibody RS7-3G11, is phosphorylated on serine 303.	Serine	105-111	tumor associated calcium signal transducer 2	Homo sapiens	33-38
7635574-5	1995	Phosphoamino acid analysis of the in vivo phosphorylated EGP-1 revealed that the phosphorylation is on serine.	Phosphoamino Acids	0-17	tumor associated calcium signal transducer 2	Homo sapiens	57-62
7635574-5	1995	Phosphoamino acid analysis of the in vivo phosphorylated EGP-1 revealed that the phosphorylation is on serine.	Serine	103-109	tumor associated calcium signal transducer 2	Homo sapiens	57-62
7635574-7	1995	In vitro analysis indicated a stoichiometry of phosphorylation of 0.54 mole of phosphate per mole of EGP-1.	Phosphates	79-88	tumor associated calcium signal transducer 2	Homo sapiens	101-106
7635574-8	1995	Phosphoamino acid analysis and phosphopeptide mapping of the antigen phosphorylated in vitro by protein kinase C showed that phosphorylation occurred on a serine residue, specifically on serine 303, located in the cytoplasmic domain of EGP-1.	Serine	155-161	tumor associated calcium signal transducer 2	Homo sapiens	236-241
7635574-8	1995	Phosphoamino acid analysis and phosphopeptide mapping of the antigen phosphorylated in vitro by protein kinase C showed that phosphorylation occurred on a serine residue, specifically on serine 303, located in the cytoplasmic domain of EGP-1.	Serine	187-193	tumor associated calcium signal transducer 2	Homo sapiens	236-241
7635574-9	1995	Treatment of ME180 cells with phorbol ester increased the phosphorylation of EGP-1.	Phorbol Esters	30-43	tumor associated calcium signal transducer 2	Homo sapiens	77-82
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Methionine	15-25	tumor associated calcium signal transducer 2	Homo sapiens	204-211
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Thiosulfates	94-105	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Thiosulfates	94-105	tumor associated calcium signal transducer 2	Homo sapiens	204-211
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Ascorbic Acid	107-116	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Ascorbic Acid	107-116	tumor associated calcium signal transducer 2	Homo sapiens	204-211
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Cysteine	118-126	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Cysteine	118-126	tumor associated calcium signal transducer 2	Homo sapiens	204-211
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Glutathione	132-143	tumor associated calcium signal transducer 2	Homo sapiens	62-69
7840660-5	1995	Using an ozone-methionine reaction rate constant of 4 x 10(6) M-1 s-1, the rate constants for thiosulfate, ascorbate, cysteine, and glutathione were 7.2 x 10(7), 4.8 x 10(7), 4.4 x 10(6), and 2.5 x 10(6) M-1 s-1, respectively.	Glutathione	132-143	tumor associated calcium signal transducer 2	Homo sapiens	204-211
8194903-7	1994	The GA733-1 genomic DNA sequence predicted a type-1 membrane protein of 35 kDa, with 4 potential N-linked glycosylation sites.	Nitrogen	21-22	tumor associated calcium signal transducer 2	Homo sapiens	4-11
8132519-8	1994	The ability of L-lactate to reduce the enzyme flavin is essentially abolished, whereas reoxidation of reduced enzyme with oxygen proceeds at 1.4 x 10(4) M-1 s-1, a rate essentially like that found in the wild type enzyme.	Oxygen	122-128	tumor associated calcium signal transducer 2	Homo sapiens	153-160
8065127-4	1994	It was found that the effect of methanesulfonyl fluoride results from a reaction between methanesulfonyl fluoride and the detection reaction product with the following rate constant: k1 = 5.33 x 10(-2) M-1s-1.	methanesulfonyl fluoride	32-56	tumor associated calcium signal transducer 2	Homo sapiens	202-208
8065127-4	1994	It was found that the effect of methanesulfonyl fluoride results from a reaction between methanesulfonyl fluoride and the detection reaction product with the following rate constant: k1 = 5.33 x 10(-2) M-1s-1.	methanesulfonyl fluoride	89-113	tumor associated calcium signal transducer 2	Homo sapiens	202-208
7810434-2	1994	Primer pairs from PRV gp50 gene were used with the enzyme uracil N-glycosylase and dUTP instead dTTP to prevent contamination due to PCR product carry-over.	deoxyuridine triphosphate	83-87	tumor associated calcium signal transducer 2	Homo sapiens	22-26
7810434-2	1994	Primer pairs from PRV gp50 gene were used with the enzyme uracil N-glycosylase and dUTP instead dTTP to prevent contamination due to PCR product carry-over.	thymidine 5'-triphosphate	96-100	tumor associated calcium signal transducer 2	Homo sapiens	22-26
1654444-9	1991	The penetration defect in the gII and gp50 deletion mutants could be overcome by experimental polyethylene glycol-induced membrane fusion.	Polyethylene Glycols	94-113	tumor associated calcium signal transducer 2	Homo sapiens	38-42
8389078-10	1993	The presence of both gIII and the essential glycoprotein gp50 (gD) was shown to be critical for heparin-resistant binding.	Heparin	96-103	tumor associated calcium signal transducer 2	Homo sapiens	57-61
8241122-3	1993	In the presence of 100 mM KCl, 1 mM MgCl2, and equimolar phalloidin, the second-order rate constant for annealing of actin filaments is 2.2 x 10(6) M-1 s-1 and the first-order rate constant for fragmentation is 7 x 10(-7) s-1.	Potassium Chloride	26-29	tumor associated calcium signal transducer 2	Homo sapiens	148-155
8241122-3	1993	In the presence of 100 mM KCl, 1 mM MgCl2, and equimolar phalloidin, the second-order rate constant for annealing of actin filaments is 2.2 x 10(6) M-1 s-1 and the first-order rate constant for fragmentation is 7 x 10(-7) s-1.	Magnesium Chloride	36-41	tumor associated calcium signal transducer 2	Homo sapiens	148-155
8241122-3	1993	In the presence of 100 mM KCl, 1 mM MgCl2, and equimolar phalloidin, the second-order rate constant for annealing of actin filaments is 2.2 x 10(6) M-1 s-1 and the first-order rate constant for fragmentation is 7 x 10(-7) s-1.	Phalloidine	57-67	tumor associated calcium signal transducer 2	Homo sapiens	148-155
1459581-6	1992	In immunofluorescence FACS analysis the FITC-T16 and FITC-MOv-16 mAbs specifically stained Trop-2 transfectants.	Fluorescein-5-isothiocyanate	40-44	tumor associated calcium signal transducer 2	Homo sapiens	91-97
1459581-6	1992	In immunofluorescence FACS analysis the FITC-T16 and FITC-MOv-16 mAbs specifically stained Trop-2 transfectants.	Fluorescein-5-isothiocyanate	53-57	tumor associated calcium signal transducer 2	Homo sapiens	91-97
1909966-10	1991	Labeling of GP50 with 3H-D-mannose was also completely inhibited by SDH.	3h-d-mannose	22-34	tumor associated calcium signal transducer 2	Homo sapiens	12-16
1909966-10	1991	Labeling of GP50 with 3H-D-mannose was also completely inhibited by SDH.	sdh	68-71	tumor associated calcium signal transducer 2	Homo sapiens	12-16
1909966-13	1991	Profound inhibition of HSP110, HSP60, and HSP50/GP50 labeling suggests that these may be associated with mechanisms of SDH sensitization.	sdh	119-122	tumor associated calcium signal transducer 2	Homo sapiens	48-52
2221918-2	1990	The rate constant for the reaction of ebselen with trichloromethylperoxyl radicals was determined to be 2.9 X 10(8) M-1 s-1, while its sulfur analogue, 2-phenyl-1,2-benzisothiazol-3(2H)one, was oxidized at much lower rates, k less than or equal to 10(7) M-1 s-1.	ebselen	38-45	tumor associated calcium signal transducer 2	Homo sapiens	116-123
1882708-3	1991	The Stern-Volmer plots yielded the second-order rate constants of 2.94 x 10(9) M-1 S-1 and 3.83 x 10(8) M-1 S-1 for quenching 1O2 with MCLA and NaN3 in water at pH 5.4, respectively.	CHEBI:63768	126-129	tumor associated calcium signal transducer 2	Homo sapiens	79-92
1882708-3	1991	The Stern-Volmer plots yielded the second-order rate constants of 2.94 x 10(9) M-1 S-1 and 3.83 x 10(8) M-1 S-1 for quenching 1O2 with MCLA and NaN3 in water at pH 5.4, respectively.	Sodium Azide	144-148	tumor associated calcium signal transducer 2	Homo sapiens	79-92
1882708-3	1991	The Stern-Volmer plots yielded the second-order rate constants of 2.94 x 10(9) M-1 S-1 and 3.83 x 10(8) M-1 S-1 for quenching 1O2 with MCLA and NaN3 in water at pH 5.4, respectively.	Water	152-157	tumor associated calcium signal transducer 2	Homo sapiens	79-92
2221918-2	1990	The rate constant for the reaction of ebselen with trichloromethylperoxyl radicals was determined to be 2.9 X 10(8) M-1 s-1, while its sulfur analogue, 2-phenyl-1,2-benzisothiazol-3(2H)one, was oxidized at much lower rates, k less than or equal to 10(7) M-1 s-1.	ebselen	38-45	tumor associated calcium signal transducer 2	Homo sapiens	254-261
2221918-2	1990	The rate constant for the reaction of ebselen with trichloromethylperoxyl radicals was determined to be 2.9 X 10(8) M-1 s-1, while its sulfur analogue, 2-phenyl-1,2-benzisothiazol-3(2H)one, was oxidized at much lower rates, k less than or equal to 10(7) M-1 s-1.	trichloromethylperoxyl radicals	51-82	tumor associated calcium signal transducer 2	Homo sapiens	116-123
2221918-2	1990	The rate constant for the reaction of ebselen with trichloromethylperoxyl radicals was determined to be 2.9 X 10(8) M-1 s-1, while its sulfur analogue, 2-phenyl-1,2-benzisothiazol-3(2H)one, was oxidized at much lower rates, k less than or equal to 10(7) M-1 s-1.	trichloromethylperoxyl radicals	51-82	tumor associated calcium signal transducer 2	Homo sapiens	254-261
34774484-0	2021	N-glycosylation status of Trop2 impacts its surface density, interaction with claudin-7 and exosomal release.	Nitrogen	0-1	tumor associated calcium signal transducer 2	Homo sapiens	26-31
2292433-2	1990	Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product.	Hydroxyl Radical	0-17	tumor associated calcium signal transducer 2	Homo sapiens	123-129
2292433-2	1990	Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product.	Hydrogen	27-35	tumor associated calcium signal transducer 2	Homo sapiens	123-129
2292433-2	1990	Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product.	beta-glycerophosphoric acid	47-67	tumor associated calcium signal transducer 2	Homo sapiens	123-129
2292433-2	1990	Hydroxyl radicals abstract hydrogen atoms from glycerol-2-phosphate with a specific rate constant of (7.0 +/- 1.5) x 10(8) M-1s-1 forming the beta-phospho radical as the major product.	beta-phospho radical	142-162	tumor associated calcium signal transducer 2	Homo sapiens	123-129
34519889-10	2022	Additionally, 89Zr-DFO-AF650 exhibited high specificity to Trop-2 in BxPC-3 cells (Kd = 22.34 +- 2.509 nM).	Deferoxamine	19-22	tumor associated calcium signal transducer 2	Homo sapiens	59-65
34519889-13	2022	CONCLUSIONS: 89Zr-DFO-AF650 can be effectively used to detect pancreatic cancer via Trop-2-mediated immunoPET in vivo, clearly revealing the great potential of Trop-2-based non-invasive imaging in pancreatic cancer detection and treatment monitoring.	Deferoxamine	18-21	tumor associated calcium signal transducer 2	Homo sapiens	84-90
34519889-13	2022	CONCLUSIONS: 89Zr-DFO-AF650 can be effectively used to detect pancreatic cancer via Trop-2-mediated immunoPET in vivo, clearly revealing the great potential of Trop-2-based non-invasive imaging in pancreatic cancer detection and treatment monitoring.	Deferoxamine	18-21	tumor associated calcium signal transducer 2	Homo sapiens	160-166
34774484-4	2021	The current study explored the significance of N-glycosylation of Trop2 by substituting specific N-glycan addition sites by site-directed mutagenesis.	Nitrogen	47-48	tumor associated calcium signal transducer 2	Homo sapiens	66-71
34774484-1	2021	Trophoblast antigen 2 (Trop2) is a type I transmembrane protein post-translationally modified by N-linked glycosylation.	Nitrogen	97-98	tumor associated calcium signal transducer 2	Homo sapiens	0-21
34774484-1	2021	Trophoblast antigen 2 (Trop2) is a type I transmembrane protein post-translationally modified by N-linked glycosylation.	Nitrogen	97-98	tumor associated calcium signal transducer 2	Homo sapiens	23-28
34413126-0	2021	Datopotamab deruxtecan (Dato-DXd), a novel TROP2-directed antibody-drug conjugate, demonstrates potent antitumor activity by efficient drug delivery to tumor cells.	Deruxtecan	12-22	tumor associated calcium signal transducer 2	Homo sapiens	43-48
34774484-4	2021	The current study explored the significance of N-glycosylation of Trop2 by substituting specific N-glycan addition sites by site-directed mutagenesis.	n-glycan	97-105	tumor associated calcium signal transducer 2	Homo sapiens	66-71
34774484-13	2021	This data suggests that site-specific N-glycan addition determines Trop2 surface density, claudin-7 interaction and exosomal release.	n-glycan	38-46	tumor associated calcium signal transducer 2	Homo sapiens	67-72
34651524-3	2021	Sacituzumab govitecan (IMMU-132) is an antibody drug conjugate (ADC) comprised of an active metabolite of irinotecan, SN-38, bound to a humanized monoclonal antibody which targets trophoblastic cell-surface antigen 2 (Trop-2).	Irinotecan	106-116	tumor associated calcium signal transducer 2	Homo sapiens	218-224
34651524-3	2021	Sacituzumab govitecan (IMMU-132) is an antibody drug conjugate (ADC) comprised of an active metabolite of irinotecan, SN-38, bound to a humanized monoclonal antibody which targets trophoblastic cell-surface antigen 2 (Trop-2).	Irinotecan	118-123	tumor associated calcium signal transducer 2	Homo sapiens	218-224
34413126-2	2021	We developed the novel TROP2-directed antibody-drug conjugate (ADC), Datopotamab deruxtecan (Dato-DXd, DS-1062a), with a potent DNA topoisomerase I inhibitor (DXd), and evaluated its antitumor activity and safety profiles in preclinical models.	datopotamab deruxtecan	69-91	tumor associated calcium signal transducer 2	Homo sapiens	23-28
34413126-2	2021	We developed the novel TROP2-directed antibody-drug conjugate (ADC), Datopotamab deruxtecan (Dato-DXd, DS-1062a), with a potent DNA topoisomerase I inhibitor (DXd), and evaluated its antitumor activity and safety profiles in preclinical models.	dato-dxd	93-101	tumor associated calcium signal transducer 2	Homo sapiens	23-28
34413126-2	2021	We developed the novel TROP2-directed antibody-drug conjugate (ADC), Datopotamab deruxtecan (Dato-DXd, DS-1062a), with a potent DNA topoisomerase I inhibitor (DXd), and evaluated its antitumor activity and safety profiles in preclinical models.	ds-1062a	103-111	tumor associated calcium signal transducer 2	Homo sapiens	23-28
34885875-3	2021	Sacituzumab govitecan (SG) is a third-generation antibody-drug conjugate, consisting of an anti-Trop-2 monoclonal antibody (hRS7), a hydrolyzable linker, and a cytotoxin (SN38), which inhibits topoisomerase 1.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	96-102
34176192-2	2021	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate that contains the irinotecan active metabolite, SN-38, linked to a humanized monoclonal antibody targeting trophoblast cell surface antigen 2 (Trop-2), which is overexpressed in many solid tumors.	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	206-212
34834563-3	2021	Sacituzumab govitecan, a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate, was recently approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA) for the treatment of metastatic triple-negative breast cancer and metastatic urothelial cancer.	govitecan	12-21	tumor associated calcium signal transducer 2	Homo sapiens	25-31
34452926-6	2021	A combination of monoclonal antibodies was used to target the prostate tumor antigen tumor-associated calcium signal transducer 2 (TROP2) and the cancer-associated fibroblast marker fibroblast activation protein alpha (FAP).	Calcium	102-109	tumor associated calcium signal transducer 2	Homo sapiens	131-136
34176192-8	2021	IMPLICATIONS FOR PRACTICE: Sacituzumab govitecan (TRODELVY) is a novel antibody-drug conjugate composed of the active metabolite of irinotecan (SN-38) conjugated to a monoclonal antibody targeting Trop-2, an epithelial cell surface antigen overexpressed in many cancers.	Irinotecan	144-149	tumor associated calcium signal transducer 2	Homo sapiens	197-203
34176192-2	2021	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate that contains the irinotecan active metabolite, SN-38, linked to a humanized monoclonal antibody targeting trophoblast cell surface antigen 2 (Trop-2), which is overexpressed in many solid tumors.	sacituzumab govitecan	23-31	tumor associated calcium signal transducer 2	Homo sapiens	206-212
34176192-2	2021	Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate that contains the irinotecan active metabolite, SN-38, linked to a humanized monoclonal antibody targeting trophoblast cell surface antigen 2 (Trop-2), which is overexpressed in many solid tumors.	Irinotecan	111-116	tumor associated calcium signal transducer 2	Homo sapiens	206-212
34176192-8	2021	IMPLICATIONS FOR PRACTICE: Sacituzumab govitecan (TRODELVY) is a novel antibody-drug conjugate composed of the active metabolite of irinotecan (SN-38) conjugated to a monoclonal antibody targeting Trop-2, an epithelial cell surface antigen overexpressed in many cancers.	Irinotecan	132-142	tumor associated calcium signal transducer 2	Homo sapiens	197-203
34335947-0	2021	Trop2 binding IGF2R induces gefitinib resistance in NSCLC by remodeling the tumor microenvironment.	Gefitinib	28-37	tumor associated calcium signal transducer 2	Homo sapiens	0-5
34116144-1	2021	BACKGROUND: The pivotal phase III ASCENT trial demonstrated improved survival outcomes associated with sacituzumab govitecan (SG), an anti-Trop-2 antibody-drug conjugate linked with the topoisomerase-inhibitor SN-38, over single-agent chemotherapy of physician"s choice (TPC) in previously-treated metastatic triple-negative breast cancer (mTNBC).	sacituzumab govitecan	103-124	tumor associated calcium signal transducer 2	Homo sapiens	139-145
34116144-1	2021	BACKGROUND: The pivotal phase III ASCENT trial demonstrated improved survival outcomes associated with sacituzumab govitecan (SG), an anti-Trop-2 antibody-drug conjugate linked with the topoisomerase-inhibitor SN-38, over single-agent chemotherapy of physician"s choice (TPC) in previously-treated metastatic triple-negative breast cancer (mTNBC).	Irinotecan	210-215	tumor associated calcium signal transducer 2	Homo sapiens	139-145
34299325-4	2021	Sacituzumab govitecan, an antibody-drug conjugate of Trop2, has recently entered clinical use for the treatment of various solid cancers.	govitecan	12-21	tumor associated calcium signal transducer 2	Homo sapiens	53-58
34299325-9	2021	These results suggest the potential use of Trop2-targeted therapy for EMPD and improve our understanding of the skin-related adverse effects of current Trop2-targeted therapies such as sacituzumab govitecan.	govitecan	197-206	tumor associated calcium signal transducer 2	Homo sapiens	152-157
34335947-8	2021	These findings deepened the understanding of the function of Trop2 and the involved mechanisms of gefitinib resistance, and may provide new molecular targets for NSCLC with gefitinib resistance.	Gefitinib	173-182	tumor associated calcium signal transducer 2	Homo sapiens	61-66
34659576-1	2021	Background: Tumor-associated calcium signal transducer 2 (TROP2) is over expressed in various kinds of human cancers and plays important roles in the proliferation, invasion and metastasis of tumor cells.	Calcium	29-36	tumor associated calcium signal transducer 2	Homo sapiens	58-63
34320447-12	2021	Recently, the anti-Trop-2 mAb Sacituzumab govitecan-hziy was shown to be active against metastatic breast cancer.	govitecan	42-51	tumor associated calcium signal transducer 2	Homo sapiens	19-25
34417961-11	2021	TACSTD2-MYSM1, LRP1B, and ASAP1-ADCY8 showed suggestive associations with serum Fe element levels (p < 5 x 10-6).	Iron	80-82	tumor associated calcium signal transducer 2	Homo sapiens	0-7
34335947-4	2021	In this study, the relationship between Trop2 and gefitinib resistance in NSCLC was investigated, and the underlying mechanism was explored.	Gefitinib	50-59	tumor associated calcium signal transducer 2	Homo sapiens	40-45
34335947-6	2021	Trop2 was confirmed to induce gefitinib resistance in NSCLC, and Trop2 binding IGF2R promoted the IGF2-IGF1R-Akt axis to enhance gefitinib resistance and remodeling the TME in NSCLC.	Gefitinib	30-39	tumor associated calcium signal transducer 2	Homo sapiens	0-5
34335947-6	2021	Trop2 was confirmed to induce gefitinib resistance in NSCLC, and Trop2 binding IGF2R promoted the IGF2-IGF1R-Akt axis to enhance gefitinib resistance and remodeling the TME in NSCLC.	Gefitinib	129-138	tumor associated calcium signal transducer 2	Homo sapiens	0-5
34335947-6	2021	Trop2 was confirmed to induce gefitinib resistance in NSCLC, and Trop2 binding IGF2R promoted the IGF2-IGF1R-Akt axis to enhance gefitinib resistance and remodeling the TME in NSCLC.	Gefitinib	129-138	tumor associated calcium signal transducer 2	Homo sapiens	65-70
34335947-8	2021	These findings deepened the understanding of the function of Trop2 and the involved mechanisms of gefitinib resistance, and may provide new molecular targets for NSCLC with gefitinib resistance.	Gefitinib	98-107	tumor associated calcium signal transducer 2	Homo sapiens	61-66
34181512-3	2022	Sacituzumab govitecan, a conjugate of anti-Trop-2 antibody and SN-38 payload (an active metabolite of irinotecan), is the first in the class that has been clinically validated and approved by the Food and Drug Administration for the treatment of metastatic triple-negative breast (2020) and urothelial carcinomas (2021).	govitecan	12-21	tumor associated calcium signal transducer 2	Homo sapiens	43-49
35530278-4	2022	SG consists of an anti-trophoblast cell-surface antigen 2 (Trop2) antibody conjugated with a topoisomerase I inhibitor, SN-38, which is diffused out of the targeted Trop2 positive cancer cells and induces the bystander killing effect on surrounding cells regardless of their Trop2 expression status.	Irinotecan	120-125	tumor associated calcium signal transducer 2	Homo sapiens	59-64
35545724-1	2022	PURPOSE: Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an anti-Trop-2 antibody coupled to SN-38 via a proprietary hydrolyzable linker.	Irinotecan	113-118	tumor associated calcium signal transducer 2	Homo sapiens	86-92
34103959-2	2021	Trophoblast cell-surface antigen2 (TROP2), a cell-signal transduction, is one of the tumor-related calcium signal transducer gene family.	Calcium	99-106	tumor associated calcium signal transducer 2	Homo sapiens	0-33
34103959-2	2021	Trophoblast cell-surface antigen2 (TROP2), a cell-signal transduction, is one of the tumor-related calcium signal transducer gene family.	Calcium	99-106	tumor associated calcium signal transducer 2	Homo sapiens	35-40
35624189-4	2022	In this research, MMAE, SN-38, and DXd were selected as candidates for payloads of the anti-Trop-2 mAb SY02.	Irinotecan	24-29	tumor associated calcium signal transducer 2	Homo sapiens	92-98
35530278-4	2022	SG consists of an anti-trophoblast cell-surface antigen 2 (Trop2) antibody conjugated with a topoisomerase I inhibitor, SN-38, which is diffused out of the targeted Trop2 positive cancer cells and induces the bystander killing effect on surrounding cells regardless of their Trop2 expression status.	Irinotecan	120-125	tumor associated calcium signal transducer 2	Homo sapiens	165-170
35530278-4	2022	SG consists of an anti-trophoblast cell-surface antigen 2 (Trop2) antibody conjugated with a topoisomerase I inhibitor, SN-38, which is diffused out of the targeted Trop2 positive cancer cells and induces the bystander killing effect on surrounding cells regardless of their Trop2 expression status.	Irinotecan	120-125	tumor associated calcium signal transducer 2	Homo sapiens	275-280
35216942-1	2022	Sacituzumab govitecan (SG) is an antibody-drug conjugate (ADC) targeting TROP2, which has recently been approved for treatment-refractory metastatic urothelial cancer (UC).	sacituzumab govitecan	0-21	tumor associated calcium signal transducer 2	Homo sapiens	73-78
35267507-6	2022	In TNBC these conjugates (Trodelvy , Glembatumumab-Vedotin, Ladiratuzumab-vedotin, Cofetuzumab-pelidotin, and PF-06647263) are directed against various targets, in particular Trop-2 glycoprotein, NMB glycoprotein, Zinc transporter LIV-1, and Ephrin receptor-4, to achieve this selective accumulation, and include campthotecins, calicheamins, or auristatins as drugs.	campthotecins	313-326	tumor associated calcium signal transducer 2	Homo sapiens	175-181
35267507-6	2022	In TNBC these conjugates (Trodelvy , Glembatumumab-Vedotin, Ladiratuzumab-vedotin, Cofetuzumab-pelidotin, and PF-06647263) are directed against various targets, in particular Trop-2 glycoprotein, NMB glycoprotein, Zinc transporter LIV-1, and Ephrin receptor-4, to achieve this selective accumulation, and include campthotecins, calicheamins, or auristatins as drugs.	calicheamins	328-340	tumor associated calcium signal transducer 2	Homo sapiens	175-181
35267507-6	2022	In TNBC these conjugates (Trodelvy , Glembatumumab-Vedotin, Ladiratuzumab-vedotin, Cofetuzumab-pelidotin, and PF-06647263) are directed against various targets, in particular Trop-2 glycoprotein, NMB glycoprotein, Zinc transporter LIV-1, and Ephrin receptor-4, to achieve this selective accumulation, and include campthotecins, calicheamins, or auristatins as drugs.	auristatin	345-356	tumor associated calcium signal transducer 2	Homo sapiens	175-181
35216942-3	2022	Using gene expression data from four clinical cohorts with >1400 patient samples of muscle-invasive BC and a BC tissue microarray, we found that TROP2 mRNA and protein are highly expressed across basal, luminal, and stroma-rich subtypes, but depleted in the neuroendocrine subtype.	Phenobarbital	203-210	tumor associated calcium signal transducer 2	Homo sapiens	145-150
35160059-4	2022	Trophoblast cell surface antigen 2 (TROP2) and sacituzumab govitecan, an antibody-drug conjugate of TROP2, have attracted attention in the treatment of various solid tumors.	sacituzumab govitecan	47-68	tumor associated calcium signal transducer 2	Homo sapiens	100-105
35160059-7	2022	These observations directly suggest that both sebaceous carcinoma and sweat gland carcinoma could be potentially treated with TROP2-targeted antibody-drug conjugates such as sacituzumab govitecan.	govitecan	186-195	tumor associated calcium signal transducer 2	Homo sapiens	126-131
35168242-1	2022	BACKGROUND: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities.	Calcium	47-54	tumor associated calcium signal transducer 2	Homo sapiens	76-81