PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9939879-0	1986	Evidence for a reversible structural transformation in the metallic glass Co58Ni10Fe5B16 Si11.	co58ni10fe5b16	74-88	helicase for meiosis 1	Homo sapiens	89-93
33340543-7	2021	Our findings suggest that mechanoregulation, which may be provided by a directly bound RNA-dependent RNA polymerase, enables on-demand helicase activity on the relevant polynucleotide substrate during viral replication.	Polynucleotides	169-183	helicase for meiosis 1	Homo sapiens	135-143
34036784-6	2021	Here, we introduce an RNA helicase assay based on graphene oxide, which enables fluorescence-based analysis of RNA substrate-specific helicase enzyme activity.	graphene oxide	50-64	helicase for meiosis 1	Homo sapiens	26-34
34036784-6	2021	Here, we introduce an RNA helicase assay based on graphene oxide, which enables fluorescence-based analysis of RNA substrate-specific helicase enzyme activity.	graphene oxide	50-64	helicase for meiosis 1	Homo sapiens	134-142
34036784-7	2021	This assay demonstrated high reliability and ability for high-throughput screening, identifying a new helicase inhibitor candidate, micafungin (MCFG), from an FDA-approved drug library.	Micafungin	132-142	helicase for meiosis 1	Homo sapiens	102-110
34036784-7	2021	This assay demonstrated high reliability and ability for high-throughput screening, identifying a new helicase inhibitor candidate, micafungin (MCFG), from an FDA-approved drug library.	Micafungin	144-148	helicase for meiosis 1	Homo sapiens	102-110
33986405-0	2021	Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase.	posaconazole	25-37	helicase for meiosis 1	Homo sapiens	82-90
33986405-0	2021	Repurposing potential of posaconazole and grazoprevir as inhibitors of SARS-CoV-2 helicase.	grazoprevir	42-53	helicase for meiosis 1	Homo sapiens	82-90
33787991-5	2021	However, single substitutions of R50, K94 or H24 or a simultaneous four-residue substitution resulted in apparent changes in the helicase activity and RNA-binding ability of NS3.	NV-5138	38-41	helicase for meiosis 1	Homo sapiens	129-137
33787991-5	2021	However, single substitutions of R50, K94 or H24 or a simultaneous four-residue substitution resulted in apparent changes in the helicase activity and RNA-binding ability of NS3.	CHEMBL1233206	45-48	helicase for meiosis 1	Homo sapiens	129-137
33855846-0	2021	A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation.	hexanucleotide	19-33	helicase for meiosis 1	Homo sapiens	2-10
33846247-0	2021	Helicase-like functions in phosphate loop containing beta-alpha polypeptides.	Phosphates	27-36	helicase for meiosis 1	Homo sapiens	0-8
32980406-10	2020	Results suggest that the cangrelor, fludarabine, folic acid and polydatin were the most potent drugs which had potency to inhibit both the wild type and mutant SARS-CoV-2 helicase.	fludarabine	36-47	helicase for meiosis 1	Homo sapiens	171-179
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Quercetin	12-21	helicase for meiosis 1	Homo sapiens	241-249
33520683-8	2021	Among them, quercetin, one of the most abundant of plant flavonoids, is proposed as a lead candidate with its ability on the virus side to inhibit SARS-CoV spike protein-angiotensin-converting enzyme 2 (ACE2) interaction, viral protease and helicase activities, as well as on the host cell side to inhibit ACE activity and increase intracellular zinc level.	Flavonoids	57-67	helicase for meiosis 1	Homo sapiens	241-249
33393898-10	2021	During infection of an exposed host cell, viral-encoded protease cleaves the polyprotein that results from translation of 5" open reading frame (ORF) of the genome, culminating in releasing of multiple nonstructural proteins such as helicase (Hel), adenosine triphosphate (ATPase) and RNA-dependent RNA polymerase (Rep).	Adenosine	249-258	helicase for meiosis 1	Homo sapiens	233-241
33393898-10	2021	During infection of an exposed host cell, viral-encoded protease cleaves the polyprotein that results from translation of 5" open reading frame (ORF) of the genome, culminating in releasing of multiple nonstructural proteins such as helicase (Hel), adenosine triphosphate (ATPase) and RNA-dependent RNA polymerase (Rep).	Adenosine	249-258	helicase for meiosis 1	Homo sapiens	243-246
33459340-3	2021	Another dsRNA binding protein PACT, originally identified as the cellular protein activator of dsRNA-activated protein kinase (PKR), is known to enhance RIG-I signaling in response to polyI:C treatment, in part by stimulating RIG-I"s ATPase and helicase activities.	Poly I-C	184-191	helicase for meiosis 1	Homo sapiens	245-253
32980406-10	2020	Results suggest that the cangrelor, fludarabine, folic acid and polydatin were the most potent drugs which had potency to inhibit both the wild type and mutant SARS-CoV-2 helicase.	Folic Acid	49-59	helicase for meiosis 1	Homo sapiens	171-179
32980406-10	2020	Results suggest that the cangrelor, fludarabine, folic acid and polydatin were the most potent drugs which had potency to inhibit both the wild type and mutant SARS-CoV-2 helicase.	polydatin	64-73	helicase for meiosis 1	Homo sapiens	171-179
32712315-10	2020	Although Cys-rich derived CPPs of helicase (NSP13) can potentially fold into a cyclic conformation in endosomes with a higher rate of endosomal release, the most optimal SCV2-CPP candidates as vectors for drug delivery were SCV2-CPP118, SCV2-CPP119, SCV2-CPP122, and SCV2-CPP129 of NSP12 (RdRp).	Cysteine	9-12	helicase for meiosis 1	Homo sapiens	34-42
33102585-10	2020	Through the analyses performed in this study, it is concluded that EryvarinM, Silydianin, Osajin, and Raddeanine can be considered potential inhibitors for MTase, while TomentodiplaconeB, Osajin, Sesquiterpene Glycoside, Rhamnetin, and Silydianin for helicase after these compounds are validated thoroughly using in vitro and in vivo protocols.	eryvarinm	67-76	helicase for meiosis 1	Homo sapiens	251-259
33102585-10	2020	Through the analyses performed in this study, it is concluded that EryvarinM, Silydianin, Osajin, and Raddeanine can be considered potential inhibitors for MTase, while TomentodiplaconeB, Osajin, Sesquiterpene Glycoside, Rhamnetin, and Silydianin for helicase after these compounds are validated thoroughly using in vitro and in vivo protocols.	peiminine	102-112	helicase for meiosis 1	Homo sapiens	251-259
29947898-5	2018	In this study, we introduce a novel system that combines thermophilic helicase-dependent amplification (tHDA) with a Triton X-100 micellar aqueous two-phase system (ATPS) to achieve cell lysis, lysate processing, and enhanced nucleic acid amplification in a simple, one-step process.	thda	104-108	helicase for meiosis 1	Homo sapiens	70-78
32686993-5	2021	Among the predicted drugs compounds, clemizole, monorden, spironolactone and tanespimycin showed high binding energies; among the studied repurposing compounds, remdesivir, simeprevir and valinomycin showed high binding energies; among the predicted acidic compounds, acetylursolic acid and hardwickiic acid gave high binding energies; while among the studied anthraquinones and glycosides compounds, ellagitannin and friedelanone showed high binding energies against 3-Chymotrypsin-like protease (3CLpro), Papain-like protease (PLpro), helicase (nsp13), RNA-dependent RNA polymerase (nsp12), 2"-O-ribose methyltransferase (nsp16) of SARS-CoV-2 and DNA-PK and CK2alpha in human.	remdesivir	161-171	helicase for meiosis 1	Homo sapiens	537-545
32545268-4	2020	Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19.	Flavonoids	38-47	helicase for meiosis 1	Homo sapiens	114-122
32494136-0	2020	Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge (Amphimedon) Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling.	Silver	117-123	helicase for meiosis 1	Homo sapiens	35-43
32161317-0	2020	A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA.	Adenosine Triphosphate	7-10	helicase for meiosis 1	Homo sapiens	88-96
32161317-10	2020	Our results suggest that duplex RNA is a preferred substrate for the helicase activity of nsP13 than duplex DNA at high ATP concentrations.	Adenosine Triphosphate	120-123	helicase for meiosis 1	Homo sapiens	69-77
31484077-0	2019	Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome.	Adenosine Triphosphate	20-23	helicase for meiosis 1	Homo sapiens	71-79
30528389-0	2019	RNAi-mediated knockdown of the Rhau helicase preferentially depletes proteins with a Guanine-quadruplex motif in the 5"-UTR of their mRNA.	Guanine	85-92	helicase for meiosis 1	Homo sapiens	36-44
30326355-0	2018	Inhibitory mechanism of 5-bromo-3-indoleacetic acid for non-structural-3 helicase hepatitis C virus with dynamics correlation network analysis.	5-Bromoindole-3-acetic acid	24-51	helicase for meiosis 1	Homo sapiens	73-81
30326355-3	2018	Compound 2t9 (5-bromo-1H-indol-3-yl acetic acid) has been identified through the integrated strategies and considered as a potential lead compound for the inactivation of HCV helicase.	5-bromo-1h-indol-3-yl acetic acid	14-47	helicase for meiosis 1	Homo sapiens	175-183
30184107-6	2018	10 and 11 to alanine had similar effect to the deletion mutant of Delta1-35, suggesting that these arginine play a role in the DNA helicase activity.	Arginine	99-107	helicase for meiosis 1	Homo sapiens	131-139
29883747-0	2018	Consecutive ribonucleoside monophosphates on template inhibit DNA replication by T7 DNA polymerase or by T7 polymerase and helicase complex.	ribonucleoside monophosphates	12-41	helicase for meiosis 1	Homo sapiens	123-131
32766580-7	2020	Our findings suggest that mechanoregulation, which may be provided by a directly bound RNA-dependent RNA polymerase, enables on-demand helicase activity on the relevant polynucleotide substrate during viral replication.	Polynucleotides	169-183	helicase for meiosis 1	Homo sapiens	135-143
31955138-0	2020	Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors.	Triazoles	49-57	helicase for meiosis 1	Homo sapiens	87-95
31955138-2	2020	Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay.	halogenated triazole	79-99	helicase for meiosis 1	Homo sapiens	136-144
32399096-6	2020	The functional binding pockets of the clinically approved drugs on SARS-CoV-2 helicase protein molecule suggest that vapreotide and atazanavir may interrupt the activities of the SARS-CoV-2 helicase.	Atazanavir Sulfate	132-142	helicase for meiosis 1	Homo sapiens	78-86
32399096-6	2020	The functional binding pockets of the clinically approved drugs on SARS-CoV-2 helicase protein molecule suggest that vapreotide and atazanavir may interrupt the activities of the SARS-CoV-2 helicase.	Atazanavir Sulfate	132-142	helicase for meiosis 1	Homo sapiens	190-198
32179686-10	2020	Concomitantly, RNA affinity, helicase, and ATPase activity of DHX15 are increased when G-patch is bound.	g-patch	87-94	helicase for meiosis 1	Homo sapiens	29-37
31980818-7	2020	Powered by ATP, the helicase motor reels in the target DNA, until it encounters the roadblock en route, which stimulates the HD nuclease.	Adenosine Triphosphate	11-14	helicase for meiosis 1	Homo sapiens	20-28
31914411-2	2020	This activity is provided by the C-terminal helicase domain of viral nonstructural protein 3 (NS3).	Carbon	33-34	helicase for meiosis 1	Homo sapiens	44-52
31914411-11	2020	These results help define the linkage between ATP hydrolysis and helicase activities within NS3 and provide insight into the biophysical mechanisms for ATPase-driven NS3 helicase function.	Adenosine Triphosphate	46-49	helicase for meiosis 1	Homo sapiens	65-73
31914411-11	2020	These results help define the linkage between ATP hydrolysis and helicase activities within NS3 and provide insight into the biophysical mechanisms for ATPase-driven NS3 helicase function.	Adenosine Triphosphate	46-49	helicase for meiosis 1	Homo sapiens	170-178
31857280-1	2019	SMARCAL1 is an ATP-driven DNA annealing helicase that is similar in structure to the chromatin regulators in the subfamily A group of the SWI/SNF-related matrix-associated actin-dependent chromatin regulators.	Adenosine Triphosphate	15-18	helicase for meiosis 1	Homo sapiens	40-48
31422817-1	2019	The human RNA helicase DDX6 is an essential component of membrane-less organelles called processing bodies (PBs).	pbs	108-111	helicase for meiosis 1	Homo sapiens	14-22
31152759-3	2019	The UL23, UL30, and UL5 genes are of greatest interest as these encode, respectively, thymidine kinase, DNA polymerase, and helicase, which, if mutated may affect the effectiveness of acyclovir, foscarnet, cidofovir, and helicase-primase inhibitors.	Acyclovir	184-193	helicase for meiosis 1	Homo sapiens	124-132
31152759-3	2019	The UL23, UL30, and UL5 genes are of greatest interest as these encode, respectively, thymidine kinase, DNA polymerase, and helicase, which, if mutated may affect the effectiveness of acyclovir, foscarnet, cidofovir, and helicase-primase inhibitors.	Foscarnet	195-204	helicase for meiosis 1	Homo sapiens	124-132
31152759-3	2019	The UL23, UL30, and UL5 genes are of greatest interest as these encode, respectively, thymidine kinase, DNA polymerase, and helicase, which, if mutated may affect the effectiveness of acyclovir, foscarnet, cidofovir, and helicase-primase inhibitors.	Cidofovir	206-215	helicase for meiosis 1	Homo sapiens	124-132
30144409-1	2018	in powdered infant formula by thermophilic helicase-dependent isothermal amplification combined with silica-coated magnetic particles separation.	Silicon Dioxide	101-107	helicase for meiosis 1	Homo sapiens	43-51
30144409-5	2018	In the present study, a thermophilic helicase-dependent isothermal amplification (tHDA) based method combined with silica-coated magnetic nanoparticles (Si-MNPs) as a DNA separator for rapid and sensitive detection of Cronobacter has been developed.	thda	82-86	helicase for meiosis 1	Homo sapiens	37-45
29853604-6	2018	Our data identify the helicase/NFkappaB/TNFalpha/COX2 axis as the key suppressive pathway of dsRNA signaling in human TME and suggest that selective targeting of TLR3 or elimination of NFkappaB/TNFalpha/COX2-driven suppression may allow for selective enhancement of type-1 immunity.Significance: This study characterizes two different poly-I:C-induced signaling pathways in their induction of immunostimulatory and suppressive factors and suggests improved ways to reprogram the TME to enhance the antitumor efficacy of immunotherapies.	Poly I	335-341	helicase for meiosis 1	Homo sapiens	22-30
29853604-6	2018	Our data identify the helicase/NFkappaB/TNFalpha/COX2 axis as the key suppressive pathway of dsRNA signaling in human TME and suggest that selective targeting of TLR3 or elimination of NFkappaB/TNFalpha/COX2-driven suppression may allow for selective enhancement of type-1 immunity.Significance: This study characterizes two different poly-I:C-induced signaling pathways in their induction of immunostimulatory and suppressive factors and suggests improved ways to reprogram the TME to enhance the antitumor efficacy of immunotherapies.	Carbon	49-50	helicase for meiosis 1	Homo sapiens	22-30
29880725-5	2018	An additional 4.7-angstrom-resolution cryo-EM structure captures the postnicking state, in which the severed NTS retracts to the helicase entrance, to be threaded for adenosine 5"-triphosphate-dependent processive degradation.	Adenosine Triphosphate	167-192	helicase for meiosis 1	Homo sapiens	129-137
29633968-3	2018	Here, crystal structures of apo and AMPPNP- and Mn2+-bound forms of the essential helicase of ZIKV refined to 1.78 and 1.3 A resolution, respectively, are reported.	Manganese(2+)	48-52	helicase for meiosis 1	Homo sapiens	82-90
30637700-9	2018	The apoptosis-inducing agent (e.g., cis-platin) showed inhibition of DNA polymerase/helicase (part of the replisomes) and also modulated (positively) a few glycolipid-glycosyltransferase (GSL-GLTs) transcriptions in the early stages (within 2 h after treatment) of apoptosis.	Cisplatin	36-46	helicase for meiosis 1	Homo sapiens	84-92
29165676-1	2018	Mycobacterial Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolysis to drive unidirectional 3"-to-5" translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes en route.	Adenosine Triphosphate	77-99	helicase for meiosis 1	Homo sapiens	58-66
29165676-1	2018	Mycobacterial Lhr is a DNA damage-inducible superfamily 2 helicase that uses adenosine triphosphate (ATP) hydrolysis to drive unidirectional 3"-to-5" translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes en route.	Adenosine Triphosphate	101-104	helicase for meiosis 1	Homo sapiens	58-66
29165676-3	2018	The crystal structure of Lhr-(1-856) in complex with AMPPNP Mg2+ and ssDNA defines a new helicase family.	magnesium ion	60-64	helicase for meiosis 1	Homo sapiens	89-97
28457609-2	2017	They are bifunctional enzymes containing a trans-esterase activity, which is responsible for nicking the DNA strand to be transferred and for covalent attachment to the resulting 5"-phosphate end, and a helicase activity, which is responsible for unwinding the DNA while it is being transported to a recipient cell.	Phosphates	182-191	helicase for meiosis 1	Homo sapiens	203-211
29534608-3	2018	This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase.	Nucleosides	70-80	helicase for meiosis 1	Homo sapiens	308-316
29078357-3	2017	SPRNT reveals two mechanical substates of the ATP hydrolysis cycle of the superfamily 2 helicase Hel308 during translocation on single-stranded DNA (ssDNA).	Adenosine Triphosphate	46-49	helicase for meiosis 1	Homo sapiens	88-96
28782763-0	2017	Solid-phase helicase dependent amplification and electrochemical detection of Salmonella on highly stable oligonucleotide-modified ITO electrodes.	Oligonucleotides	106-121	helicase for meiosis 1	Homo sapiens	12-20
28526589-3	2017	In this study, we developed a rapid, simple and portable Salmonella detection strategy that combines thermophilic helicase-dependent amplification (tHDA) with a lateral flow assay to provide a detection result based on visual signals within 90 min.	thda	148-152	helicase for meiosis 1	Homo sapiens	114-122
27173619-5	2016	The 2-aminopurine fluorescence-based method provide structural information on the leading strand helicase-polymerase complex, such as the distance between the two enzymes, their relative positions at the replication fork, and their roles in fork junction melting.	2-Aminopurine	4-17	helicase for meiosis 1	Homo sapiens	97-105
28100692-3	2017	In this study, we have determined crystal structures of the core helicase domain of RECQL5 both with and without the nucleotide ADP in two distinctly different ("Open" and "Closed") conformations.	Adenosine Diphosphate	128-131	helicase for meiosis 1	Homo sapiens	65-73
27810598-0	2017	In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.	Piperazine	56-66	helicase for meiosis 1	Homo sapiens	122-130
28180308-0	2017	Functional link between DEAH/RHA helicase Prp43 activation and ATP base binding.	Adenosine Triphosphate	63-66	helicase for meiosis 1	Homo sapiens	33-41
28180308-5	2017	Using Prp43 F357A mutants or pyrimidine nucleotides, we show that the lack of stacking of the nucleotide base to the F-motif decouples the NTPase and helicase activities of Prp43.	Pyrimidine Nucleotides	29-51	helicase for meiosis 1	Homo sapiens	150-158
32313349-0	2016	Selective Inhibition of Enzymatic Activities of Severe Acute Respiratory Syndrome Coronavirus Helicase with a Thioxopyrimidine Derivative.	thioxopyrimidine	110-126	helicase for meiosis 1	Homo sapiens	94-102
27644328-5	2016	Eviction of the stalled helicase involves K48-linked polyubiquitylation of MCM7, p97-mediated extraction of CMG, and a largely degradation-independent mechanism of MCM7 deubiquitylation.	N(2)-carboxymethylguanosine	108-111	helicase for meiosis 1	Homo sapiens	24-32
27809838-5	2016	METHODS: ATP-dependent DNA helicase gene (PfRuvB3) of Plasmodium falciparum strain K1, a chloroquine and pyrimethamine-resistant strain, was inserted into pQE-TriSystem His-Strep 2 vector, heterologously expressed and affinity purified.	Adenosine Triphosphate	9-12	helicase for meiosis 1	Homo sapiens	27-35
27809838-5	2016	METHODS: ATP-dependent DNA helicase gene (PfRuvB3) of Plasmodium falciparum strain K1, a chloroquine and pyrimethamine-resistant strain, was inserted into pQE-TriSystem His-Strep 2 vector, heterologously expressed and affinity purified.	Chloroquine	89-100	helicase for meiosis 1	Homo sapiens	27-35
27809838-5	2016	METHODS: ATP-dependent DNA helicase gene (PfRuvB3) of Plasmodium falciparum strain K1, a chloroquine and pyrimethamine-resistant strain, was inserted into pQE-TriSystem His-Strep 2 vector, heterologously expressed and affinity purified.	Pyrimethamine	105-118	helicase for meiosis 1	Homo sapiens	27-35
27809838-5	2016	METHODS: ATP-dependent DNA helicase gene (PfRuvB3) of Plasmodium falciparum strain K1, a chloroquine and pyrimethamine-resistant strain, was inserted into pQE-TriSystem His-Strep 2 vector, heterologously expressed and affinity purified.	Histidine	169-172	helicase for meiosis 1	Homo sapiens	27-35
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	cupric ion	56-60	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	magnesium ion	62-66	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	ni+2	68-72	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	Zinc	76-80	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	Adenosine Triphosphate	86-89	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	2'-deoxyadenosine triphosphate	93-97	helicase for meiosis 1	Homo sapiens	4-12
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	Sodium Chloride	123-127	helicase for meiosis 1	Homo sapiens	4-12
27809838-11	2016	PfRuvB3.is inhibited by doxorubicin, daunorubicin and netropsin, known DNA helicase inhibitors.	Doxorubicin	24-35	helicase for meiosis 1	Homo sapiens	75-83
27809838-11	2016	PfRuvB3.is inhibited by doxorubicin, daunorubicin and netropsin, known DNA helicase inhibitors.	Daunorubicin	37-49	helicase for meiosis 1	Homo sapiens	75-83
27223403-5	2016	Synthetic oligonucleotides site-specifically labeled with Cy3 and Cy5 fluorophores can be used to create a variety of DNA substrates that can be used to characterize DNA binding, as well as helicase translocation and duplex unwinding activities.	Oligonucleotides	10-26	helicase for meiosis 1	Homo sapiens	190-198
27223403-5	2016	Synthetic oligonucleotides site-specifically labeled with Cy3 and Cy5 fluorophores can be used to create a variety of DNA substrates that can be used to characterize DNA binding, as well as helicase translocation and duplex unwinding activities.	cy3	58-61	helicase for meiosis 1	Homo sapiens	190-198
27223403-5	2016	Synthetic oligonucleotides site-specifically labeled with Cy3 and Cy5 fluorophores can be used to create a variety of DNA substrates that can be used to characterize DNA binding, as well as helicase translocation and duplex unwinding activities.	cyanine dye 5	66-69	helicase for meiosis 1	Homo sapiens	190-198
26507855-2	2015	Upon recognising an unmodified DNA target site, the helicase-like domain hydrolyzes ATP to cause site release (remodeling activity) and to then drive downstream translocation consuming 1-2 ATP per base pair (motor activity).	Adenosine Triphosphate	84-87	helicase for meiosis 1	Homo sapiens	52-60
27430951-6	2016	This is the first structure of any flavivirus helicase bound to ATP.	Adenosine Triphosphate	64-67	helicase for meiosis 1	Homo sapiens	46-54
26445091-0	2016	Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.	Resveratrol	20-31	helicase for meiosis 1	Homo sapiens	84-92
26889705-2	2016	Recently we reported that mutations in Primase subunits or factors that bridge Polalpha/Primase with the replicative helicase, Ctf4, caused abnormal usage of DDT pathways, negatively influenced sister chromatid cohesion (SCC), and associated with increased fork reversal.	DDT	158-161	helicase for meiosis 1	Homo sapiens	117-125
26387819-1	2015	A new chemical inhibitor against severe acute respiratory syndrome (SARS) coronavirus helicase, 7-ethyl-8-mercapto-3-methyl-3,7-dihydro-1H-purine-2,6-dione, was identified.	BAS 00162658	96-155	helicase for meiosis 1	Homo sapiens	86-94
26387819-3	2015	The compound suppressed both ATP hydrolysis and double-stranded DNA unwinding activities of helicase with IC50 values of 8.66 +- 0.26 muM and 41.6 +- 2.3 muM, respectively.	Adenosine Triphosphate	29-32	helicase for meiosis 1	Homo sapiens	92-100
26338774-2	2015	In S-phase, Dbf4-dependent kinase (DDK) and cyclin-dependent-kinase (CDK) direct with the help of a large number of helicase-activation factors the assembly of a Cdc45-MCM2-7-GINS (CMG) complex.	N(2)-carboxymethylguanosine	181-184	helicase for meiosis 1	Homo sapiens	116-124
27235397-2	2016	In many cases, these enzymes function as large multicomponent complexes that in general comprise a central ATP-dependent Snf2 family helicase that is decorated with a variable number of regulatory subunits.	Adenosine Triphosphate	107-110	helicase for meiosis 1	Homo sapiens	133-141
26690725-2	2016	We demonstrate, for the first time, zero-background helicase-dependent amplification (HDA), with low concentrations of both ATP and dNTPs.	Adenosine Triphosphate	124-127	helicase for meiosis 1	Homo sapiens	52-60
26690725-2	2016	We demonstrate, for the first time, zero-background helicase-dependent amplification (HDA), with low concentrations of both ATP and dNTPs.	Parathion	132-137	helicase for meiosis 1	Homo sapiens	52-60
27186411-1	2016	DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box protein, which is a cluster of ATP-dependent and the largest family of RNA helicase.	Adenosine Triphosphate	110-113	helicase for meiosis 1	Homo sapiens	13-21
27186411-1	2016	DEAD-box RNA helicase 3 (DDX3) is a highly conserved family member of DEAD-box protein, which is a cluster of ATP-dependent and the largest family of RNA helicase.	Adenosine Triphosphate	110-113	helicase for meiosis 1	Homo sapiens	154-162
26507855-2	2015	Upon recognising an unmodified DNA target site, the helicase-like domain hydrolyzes ATP to cause site release (remodeling activity) and to then drive downstream translocation consuming 1-2 ATP per base pair (motor activity).	Adenosine Triphosphate	189-192	helicase for meiosis 1	Homo sapiens	52-60
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Iron	132-136	helicase for meiosis 1	Homo sapiens	57-65
26120835-3	2015	Here we demonstrate that Xpo1 and Ran[GTP] together reduce the RNA-stimulated ATPase and helicase activities of Ded1.	Guanosine Triphosphate	38-41	helicase for meiosis 1	Homo sapiens	89-97
26455304-3	2015	RECQ1 is an ATP-dependent DNA-unwinding enzyme (helicase) [8, 9] with roles in replication [10-12] and DNA repair [13-16].	Adenosine Triphosphate	12-15	helicase for meiosis 1	Homo sapiens	48-56
25897079-0	2015	The Association of the Xeroderma Pigmentosum Group D DNA Helicase (XPD) with Transcription Factor IIH Is Regulated by the Cytosolic Iron-Sulfur Cluster Assembly Pathway.	Sulfur	137-143	helicase for meiosis 1	Homo sapiens	57-65
25643815-5	2015	An alanine mutation in the Walker A motif (K189A rNSs) decreased DNA helicase activity substantially, whereas a mutation in the Walker B motif resulted in a marginal decrease in this activity.	Alanine	3-10	helicase for meiosis 1	Homo sapiens	69-77
25643815-2	2015	ATP hydrolysis is an essential function of a true helicase.	Adenosine Triphosphate	0-3	helicase for meiosis 1	Homo sapiens	50-58
25970034-3	2015	Our 2-aminopurine studies show that helicase and polymerase both participate in DNA melting, but each enzyme melts the junction base pair partially.	2-Aminopurine	4-17	helicase for meiosis 1	Homo sapiens	36-44
25970034-5	2015	The synergistic shift in equilibrium of junction base pair melting by combined enzymes explains the cooperativity, wherein helicase stimulates the polymerase by promoting dNTP binding (decreasing dNTP Km), polymerase stimulates the helicase by increasing the unwinding rate-constant (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes translocating on single-stranded DNA.	Parathion	171-175	helicase for meiosis 1	Homo sapiens	123-131
25970034-5	2015	The synergistic shift in equilibrium of junction base pair melting by combined enzymes explains the cooperativity, wherein helicase stimulates the polymerase by promoting dNTP binding (decreasing dNTP Km), polymerase stimulates the helicase by increasing the unwinding rate-constant (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes translocating on single-stranded DNA.	Parathion	171-175	helicase for meiosis 1	Homo sapiens	232-240
25970034-5	2015	The synergistic shift in equilibrium of junction base pair melting by combined enzymes explains the cooperativity, wherein helicase stimulates the polymerase by promoting dNTP binding (decreasing dNTP Km), polymerase stimulates the helicase by increasing the unwinding rate-constant (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes translocating on single-stranded DNA.	Parathion	196-200	helicase for meiosis 1	Homo sapiens	123-131
25970034-5	2015	The synergistic shift in equilibrium of junction base pair melting by combined enzymes explains the cooperativity, wherein helicase stimulates the polymerase by promoting dNTP binding (decreasing dNTP Km), polymerase stimulates the helicase by increasing the unwinding rate-constant (kcat), consequently the combined enzymes unwind DNA with kinetic parameters resembling enzymes translocating on single-stranded DNA.	Parathion	196-200	helicase for meiosis 1	Homo sapiens	232-240
24333153-5	2014	A non-radioactive RNA unwinding assay was developed using biotin and digoxigenin labeled duplex RNA substrate with 5" overhangs for measuring strand displacement activity of the helicase.	Digoxigenin	69-80	helicase for meiosis 1	Homo sapiens	178-186
25308420-4	2015	The MCM2-7 helicase activity, however, is only triggered during S-phase once the holo-helicase Cdc45-MCM2-7-GINS (CMG) has been formed.	-7-gins	105-112	helicase for meiosis 1	Homo sapiens	11-19
25308420-4	2015	The MCM2-7 helicase activity, however, is only triggered during S-phase once the holo-helicase Cdc45-MCM2-7-GINS (CMG) has been formed.	-7-gins	105-112	helicase for meiosis 1	Homo sapiens	86-94
25308420-4	2015	The MCM2-7 helicase activity, however, is only triggered during S-phase once the holo-helicase Cdc45-MCM2-7-GINS (CMG) has been formed.	N(2)-carboxymethylguanosine	114-117	helicase for meiosis 1	Homo sapiens	11-19
25308420-4	2015	The MCM2-7 helicase activity, however, is only triggered during S-phase once the holo-helicase Cdc45-MCM2-7-GINS (CMG) has been formed.	N(2)-carboxymethylguanosine	114-117	helicase for meiosis 1	Homo sapiens	86-94
25453344-2	2014	LTA is a hexameric protein with a helicase activity that is powered by ATP binding and hydrolysis.	Adenosine Triphosphate	71-74	helicase for meiosis 1	Homo sapiens	34-42
25087876-3	2014	Mcm2-7 complexes containing ATPase-motif mutations showed Mcm2-7 ATP binding and hydrolysis are required for helicase loading.	Adenosine Triphosphate	28-31	helicase for meiosis 1	Homo sapiens	109-117
24816114-0	2014	Structure of human Bloom"s syndrome helicase in complex with ADP and duplex DNA.	Adenosine Diphosphate	61-64	helicase for meiosis 1	Homo sapiens	36-44
24816114-5	2014	Here, the crystal structure of the human BLM helicase in complex with ADP and a 3"-overhang DNA duplex is reported.	Adenosine Diphosphate	70-73	helicase for meiosis 1	Homo sapiens	45-53
24573678-1	2014	Helicases are molecular motors that couple the energy of ATP hydrolysis to the unwinding and remodeling of structured DNA or RNA, which is coordinated by conserved helicase motifs.	Adenosine Triphosphate	57-60	helicase for meiosis 1	Homo sapiens	164-172
24369429-3	2014	The high-resolution structure of the arterivirus helicase (nsp10), alone and in complex with a polynucleotide substrate, now provides first insights into the structural basis for nidovirus helicase function.	Polynucleotides	95-109	helicase for meiosis 1	Homo sapiens	49-57
24369429-3	2014	The high-resolution structure of the arterivirus helicase (nsp10), alone and in complex with a polynucleotide substrate, now provides first insights into the structural basis for nidovirus helicase function.	Polynucleotides	95-109	helicase for meiosis 1	Homo sapiens	189-197
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	Nucleosides	26-37	helicase for meiosis 1	Homo sapiens	228-236
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	Nucleosides	26-37	helicase for meiosis 1	Homo sapiens	251-259
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	rens	39-43	helicase for meiosis 1	Homo sapiens	228-236
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	rens	39-43	helicase for meiosis 1	Homo sapiens	251-259
28808523-2	2015	The Ir(iii) complex 9, [Ir(phq)2(phen)]PF6 (where phq = 2-phenylquinoline; phen = 1,10-phenanthroline), exhibited high luminescence in the presence of G-quadruplex DNA compared to dsDNA and ssDNA, and was employed to construct a label-free G-quadruplex-based assay for hepatitis C virus NS3 helicase activity in aqueous solution.	[ir(phq)2(phen)]pf6	23-42	helicase for meiosis 1	Homo sapiens	291-299
28808523-2	2015	The Ir(iii) complex 9, [Ir(phq)2(phen)]PF6 (where phq = 2-phenylquinoline; phen = 1,10-phenanthroline), exhibited high luminescence in the presence of G-quadruplex DNA compared to dsDNA and ssDNA, and was employed to construct a label-free G-quadruplex-based assay for hepatitis C virus NS3 helicase activity in aqueous solution.	1,10-phenanthroline	82-101	helicase for meiosis 1	Homo sapiens	291-299
25670384-4	2015	The function of the helicase-primase complex is then summarized and the development of new inhibitors of the helicase-primase complex, such as pritelivir and amenamevir, is discussed.	pritelivir	143-153	helicase for meiosis 1	Homo sapiens	20-28
25670384-4	2015	The function of the helicase-primase complex is then summarized and the development of new inhibitors of the helicase-primase complex, such as pritelivir and amenamevir, is discussed.	pritelivir	143-153	helicase for meiosis 1	Homo sapiens	109-117
25670384-4	2015	The function of the helicase-primase complex is then summarized and the development of new inhibitors of the helicase-primase complex, such as pritelivir and amenamevir, is discussed.	ASP2151	158-168	helicase for meiosis 1	Homo sapiens	20-28
25670384-4	2015	The function of the helicase-primase complex is then summarized and the development of new inhibitors of the helicase-primase complex, such as pritelivir and amenamevir, is discussed.	ASP2151	158-168	helicase for meiosis 1	Homo sapiens	109-117
25184677-3	2014	A central NMD factor is the ATP-dependent RNA helicase upframeshift 1 (UPF1).	Adenosine Triphosphate	28-31	helicase for meiosis 1	Homo sapiens	46-54
25184677-7	2014	Immunoprecipitations of UPF1 variants deficient in various aspects of the NMD process in parallel with Forster resonance energy transfer (FRET) experiments reveal that ATPase/helicase-deficient UPF1 manifests high levels of RNA binding and disregulated hyperphosphorylation, whereas wild-type UPF1 releases from nonspecific RNA interactions in an ATP hydrolysis-dependent mechanism until an NMD target is identified.	Adenosine Triphosphate	168-171	helicase for meiosis 1	Homo sapiens	175-183
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Aspartic Acid	135-138	helicase for meiosis 1	Homo sapiens	227-235
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Alanine	143-146	helicase for meiosis 1	Homo sapiens	227-235
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	147-150	helicase for meiosis 1	Homo sapiens	227-235
24821782-2	2014	Here, we report the identification of a unique cytosolic nucleic acid cosensor in human airway epithelial cells and fibroblasts: DEAH (Asp-Glu-Ala-His) box polypeptide 29 (DHX29), a member of the DExD/H (Asp-Glu-x-Asp/His)-box helicase family.	Histidine	218-221	helicase for meiosis 1	Homo sapiens	227-235
24630996-1	2014	By simultaneously measuring DNA synthesis and dNTP hydrolysis, we show that T7 DNA polymerase and T7 gp4 helicase move in sync during leading-strand synthesis, taking one-nucleotide steps and hydrolyzing one dNTP per base-pair unwound/copied.	Parathion	46-50	helicase for meiosis 1	Homo sapiens	105-113
24630996-1	2014	By simultaneously measuring DNA synthesis and dNTP hydrolysis, we show that T7 DNA polymerase and T7 gp4 helicase move in sync during leading-strand synthesis, taking one-nucleotide steps and hydrolyzing one dNTP per base-pair unwound/copied.	Parathion	208-212	helicase for meiosis 1	Homo sapiens	105-113
24630996-2	2014	The cooperative catalysis enables the helicase and polymerase to move at a uniformly fast rate without guanine:cytosine (GC) dependency or idling with futile NTP hydrolysis.	Guanine	103-110	helicase for meiosis 1	Homo sapiens	38-46
24630996-2	2014	The cooperative catalysis enables the helicase and polymerase to move at a uniformly fast rate without guanine:cytosine (GC) dependency or idling with futile NTP hydrolysis.	Cytosine	111-119	helicase for meiosis 1	Homo sapiens	38-46
24630996-2	2014	The cooperative catalysis enables the helicase and polymerase to move at a uniformly fast rate without guanine:cytosine (GC) dependency or idling with futile NTP hydrolysis.	gallocatechol	121-123	helicase for meiosis 1	Homo sapiens	38-46
24630996-2	2014	The cooperative catalysis enables the helicase and polymerase to move at a uniformly fast rate without guanine:cytosine (GC) dependency or idling with futile NTP hydrolysis.	ntp	158-161	helicase for meiosis 1	Homo sapiens	38-46
24001138-0	2013	Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase.	Ciprofloxacin	0-13	helicase for meiosis 1	Homo sapiens	56-64
23948158-0	2013	Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase.	Adenosine Triphosphate	22-25	helicase for meiosis 1	Homo sapiens	99-107
23948158-6	2013	The concentrations of enzyme, substrate, capture strand, ATP, and divalent ions were optimised in the ATPase and helicase reactions.	Adenosine Triphosphate	57-60	helicase for meiosis 1	Homo sapiens	113-121
25095995-5	2014	Reopening of the helicase core occurs after ATP hydrolysis and is coupled to phosphate release and dissociation of the second RNA strand.Fluorescence spectroscopy provides an array of approaches to study intermolecular interactions, local structural rearrangements, or large conformational changes of biomolecules.	Adenosine Triphosphate	44-47	helicase for meiosis 1	Homo sapiens	17-25
25095995-5	2014	Reopening of the helicase core occurs after ATP hydrolysis and is coupled to phosphate release and dissociation of the second RNA strand.Fluorescence spectroscopy provides an array of approaches to study intermolecular interactions, local structural rearrangements, or large conformational changes of biomolecules.	Phosphates	77-86	helicase for meiosis 1	Homo sapiens	17-25
24001138-4	2013	Ciprofloxacin blocks the DNA helicase activity of Mcm2-7 at concentrations that have little effect on other tested helicases and prevents the proliferation of both yeast and human cells at concentrations similar to those that inhibit DNA unwinding.	Ciprofloxacin	0-13	helicase for meiosis 1	Homo sapiens	29-37
24001138-6	2013	To identify more potent Mcm2-7 inhibitors, we screened molecules that are structurally related to ciprofloxacin and identified several that compromise the Mcm2-7 helicase activity at lower concentrations.	Ciprofloxacin	98-111	helicase for meiosis 1	Homo sapiens	162-170
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	helicase for meiosis 1	Homo sapiens	0-8
23893289-1	2013	Helicase motif VI is a short arginine-rich motif within the NTPase/helicase domain of the non-structural protein 3 (NS3) of the hepatitis C virus (HCV).	Arginine	29-37	helicase for meiosis 1	Homo sapiens	67-75
23893289-7	2013	These findings were confirmed for the wild-type NTPase/helicase domain in a non-radiometric PKC inhibition assay with ATP regeneration to rule out any effect of ATP hydrolysis caused by its NTPase activity.	Adenosine Triphosphate	118-121	helicase for meiosis 1	Homo sapiens	55-63
24228882-5	2013	The 56.5 kDa NS3h protein was purified by metal-chelate affinity chromatography followed by renaturation, mediated by artificial chaperone-assisted refolding, which yielded the active helicase.	Metals	42-47	helicase for meiosis 1	Homo sapiens	184-192
23583337-4	2013	Our biochemical experiments with purified mutant recombinant WRN protein showed that the G574R mutation inhibits ATP binding, and thereby leads to significant decrease in helicase activity.	Adenosine Triphosphate	113-116	helicase for meiosis 1	Homo sapiens	171-179
23543057-6	2013	L3MBTL1 is known to regulate nucleosomal compaction, and we here showed that SGK2 inactivated BRG1, a key ATP-dependent helicase within the SWI/SNF complex that regulates nucleosomal positioning.	Adenosine Triphosphate	106-109	helicase for meiosis 1	Homo sapiens	120-128
23578280-5	2013	We confirmed that gp41 helicase monomer subunits form stable hexameric helicases in the presence of GTP and that the resulting (gp41)(6) complexes bind only weakly at DNA fork junctions.	Guanosine Triphosphate	100-103	helicase for meiosis 1	Homo sapiens	23-31
23678398-11	2013	On the contrary, C4 spends most of its conformational time in a straight, more rigid formation that allows it to successfully block the passage of the oligonucleotide in the ssRNA channel of the HCV helicase.	Oligonucleotides	151-166	helicase for meiosis 1	Homo sapiens	199-207
23534463-0	2013	Potent in vitro interference of fleroxacin in DNA-binding, unwinding and ATPase activities of Bloom helicase.	Fleroxacin	32-42	helicase for meiosis 1	Homo sapiens	100-108
23534463-1	2013	OBJECTIVE: To study the effect of fleroxacin (FLRX) on biological properties of Bloom (BLM) helicase catalytic core (BLM642-1290 helicase) in vitro and the molecular mechanism of interaction between the two molecules.	Fleroxacin	34-44	helicase for meiosis 1	Homo sapiens	92-100
23534463-1	2013	OBJECTIVE: To study the effect of fleroxacin (FLRX) on biological properties of Bloom (BLM) helicase catalytic core (BLM642-1290 helicase) in vitro and the molecular mechanism of interaction between the two molecules.	Fleroxacin	34-44	helicase for meiosis 1	Homo sapiens	129-137
23534463-1	2013	OBJECTIVE: To study the effect of fleroxacin (FLRX) on biological properties of Bloom (BLM) helicase catalytic core (BLM642-1290 helicase) in vitro and the molecular mechanism of interaction between the two molecules.	Fleroxacin	46-50	helicase for meiosis 1	Homo sapiens	92-100
23534463-1	2013	OBJECTIVE: To study the effect of fleroxacin (FLRX) on biological properties of Bloom (BLM) helicase catalytic core (BLM642-1290 helicase) in vitro and the molecular mechanism of interaction between the two molecules.	Fleroxacin	46-50	helicase for meiosis 1	Homo sapiens	129-137
23534463-2	2013	METHODS: DNA-binding and unwinding activities of BLM642-1290 helicase were assayed by fluorescence polarization and gel retardation assay under conditions that the helicase was subjected to different concentrations of FLRX.	Fleroxacin	218-222	helicase for meiosis 1	Homo sapiens	61-69
23534463-2	2013	METHODS: DNA-binding and unwinding activities of BLM642-1290 helicase were assayed by fluorescence polarization and gel retardation assay under conditions that the helicase was subjected to different concentrations of FLRX.	Fleroxacin	218-222	helicase for meiosis 1	Homo sapiens	164-172
23534463-3	2013	Effect of FLRX on helicase ATPase activity was analyzed by phosphorus-free assay based on a colorimetric estimation of ATP hydrolysis-produced inorganic phosphate.	Fleroxacin	10-14	helicase for meiosis 1	Homo sapiens	18-26
23534463-3	2013	Effect of FLRX on helicase ATPase activity was analyzed by phosphorus-free assay based on a colorimetric estimation of ATP hydrolysis-produced inorganic phosphate.	Phosphorus	59-69	helicase for meiosis 1	Homo sapiens	18-26
23534463-3	2013	Effect of FLRX on helicase ATPase activity was analyzed by phosphorus-free assay based on a colorimetric estimation of ATP hydrolysis-produced inorganic phosphate.	Adenosine Triphosphate	27-30	helicase for meiosis 1	Homo sapiens	18-26
23534463-3	2013	Effect of FLRX on helicase ATPase activity was analyzed by phosphorus-free assay based on a colorimetric estimation of ATP hydrolysis-produced inorganic phosphate.	Phosphates	143-162	helicase for meiosis 1	Homo sapiens	18-26
23534463-8	2013	The biological activity of helicase was affected by FLRX, which may be through an allosteric mechanism and stabilization of enzyme conformation in low helicase activity state, disruption of the coupling of ATP hydrolysis to unwinding, and blocking helicase translocation on DNA strands.	Fleroxacin	52-56	helicase for meiosis 1	Homo sapiens	27-35
23534463-8	2013	The biological activity of helicase was affected by FLRX, which may be through an allosteric mechanism and stabilization of enzyme conformation in low helicase activity state, disruption of the coupling of ATP hydrolysis to unwinding, and blocking helicase translocation on DNA strands.	Fleroxacin	52-56	helicase for meiosis 1	Homo sapiens	151-159
23534463-8	2013	The biological activity of helicase was affected by FLRX, which may be through an allosteric mechanism and stabilization of enzyme conformation in low helicase activity state, disruption of the coupling of ATP hydrolysis to unwinding, and blocking helicase translocation on DNA strands.	Fleroxacin	52-56	helicase for meiosis 1	Homo sapiens	151-159
23534463-8	2013	The biological activity of helicase was affected by FLRX, which may be through an allosteric mechanism and stabilization of enzyme conformation in low helicase activity state, disruption of the coupling of ATP hydrolysis to unwinding, and blocking helicase translocation on DNA strands.	Adenosine Triphosphate	206-209	helicase for meiosis 1	Homo sapiens	27-35
23534463-9	2013	CONCLUSION: FLRX may affect the biological activities and conformation of BLM642-1290 helicase, and DNA helicase may be used as a promising drug target for some diseases.	Fleroxacin	12-16	helicase for meiosis 1	Homo sapiens	86-94
23483279-0	2013	A new helicase assay based on graphene oxide for anti-viral drug development.	graphene oxide	30-44	helicase for meiosis 1	Homo sapiens	6-14
23483279-3	2013	In this review, we discuss recent advances in GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed in high-throughput screening to discover selective helicase inhibitors.	graphene oxide	46-48	helicase for meiosis 1	Homo sapiens	105-113
23483279-3	2013	In this review, we discuss recent advances in GO-based biosensors focusing on a novel assay platform for helicase activity, which was also employed in high-throughput screening to discover selective helicase inhibitors.	graphene oxide	46-48	helicase for meiosis 1	Homo sapiens	199-207
23275559-3	2013	In human, both the ATP-dependent RNA helicase activity and the phosphorylation of Upf1 are essential for NMD.	Adenosine Triphosphate	19-22	helicase for meiosis 1	Homo sapiens	37-45
23410932-0	2013	Use of the SYBR Green dye for measuring helicase activity.	sybr green	11-21	helicase for meiosis 1	Homo sapiens	40-48
23410932-1	2013	Here we describe a non-radioactive assay that exploits the fluorescent dye SYBR Green to measure the helicase enzyme activity.	sybr green	75-85	helicase for meiosis 1	Homo sapiens	101-109
23290078-2	2013	Parvovirus nonstructural protein 1 (NS1) contains various activities required for parvoviral DNA replication, like endonuclease, helicase and ATPase, which are regulated by serine/threonine phosphorylation.	Serine	173-179	helicase for meiosis 1	Homo sapiens	129-137
23290078-2	2013	Parvovirus nonstructural protein 1 (NS1) contains various activities required for parvoviral DNA replication, like endonuclease, helicase and ATPase, which are regulated by serine/threonine phosphorylation.	Threonine	180-189	helicase for meiosis 1	Homo sapiens	129-137
23290078-6	2013	Moreover, using different phosphatases, we uncovered that both serine/threonine and tyrosine phosphorylations are critical for NS1 endonuclease and helicase activities.	Serine	63-69	helicase for meiosis 1	Homo sapiens	148-156
23290078-6	2013	Moreover, using different phosphatases, we uncovered that both serine/threonine and tyrosine phosphorylations are critical for NS1 endonuclease and helicase activities.	Threonine	70-79	helicase for meiosis 1	Homo sapiens	148-156
23290078-6	2013	Moreover, using different phosphatases, we uncovered that both serine/threonine and tyrosine phosphorylations are critical for NS1 endonuclease and helicase activities.	Tyrosine	84-92	helicase for meiosis 1	Homo sapiens	148-156
23275559-6	2013	With different biochemical approaches we show that this domain, named SQ, directly interacts with the helicase domain to impede ATP hydrolysis and RNA unwinding.	Adenosine Triphosphate	128-131	helicase for meiosis 1	Homo sapiens	102-110
22753105-5	2012	Our studies also illustrate how signals are transduced between the ATP and DNA binding sites to generate the helicase activity pivotal to handover and formation of the UvrB2-DNA complex, providing key insights into the configurations of these important repair intermediates.	Adenosine Triphosphate	67-70	helicase for meiosis 1	Homo sapiens	109-117
22833015-6	2012	The results from our study reveal that both the protease and helicase residues of the NS3/4A participate in the interactions with the inhibitor , ITMN-191 and 4B5A.	danoprevir	146-154	helicase for meiosis 1	Homo sapiens	61-69
22935448-5	2012	We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein.	Flavonoids	192-202	helicase for meiosis 1	Homo sapiens	172-180
22935448-5	2012	We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein.	myricetin	204-213	helicase for meiosis 1	Homo sapiens	172-180
22935448-5	2012	We also discuss the recent progress in the identification of novel chemical inhibitors of nsP13 in the context of our recent discovery of the strong inhibition of the SARS helicase by natural flavonoids, myricetin and scutellarein.	scutellarein	218-230	helicase for meiosis 1	Homo sapiens	172-180
22504228-0	2012	Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase.	bis(p-chlorophenyl)acetic acid	0-3	helicase for meiosis 1	Homo sapiens	4-12
22523084-1	2012	DNA cleavage by the Type III Restriction-Modification (RM) enzymes requires the binding of a pair of RM enzymes at two distant, inversely orientated recognition sequences followed by helicase-catalysed ATP hydrolysis and long-range communication.	Adenosine Triphosphate	202-205	helicase for meiosis 1	Homo sapiens	183-191
22504228-0	2012	Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase.	bis(p-chlorophenyl)acetic acid	0-3	helicase for meiosis 1	Homo sapiens	121-129
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Iron	60-64	helicase for meiosis 1	Homo sapiens	4-12
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Iron	60-64	helicase for meiosis 1	Homo sapiens	17-25
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Sulfur	65-71	helicase for meiosis 1	Homo sapiens	4-12
22287629-0	2012	DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster.	Sulfur	65-71	helicase for meiosis 1	Homo sapiens	17-25
22287629-5	2012	We will discuss testable models for how the conserved Fe-S cluster might operate in helicase and helicase-nuclease enzymes to conduct their specialized functions that help to preserve the integrity of the genome.	Iron	54-58	helicase for meiosis 1	Homo sapiens	84-92
22287629-5	2012	We will discuss testable models for how the conserved Fe-S cluster might operate in helicase and helicase-nuclease enzymes to conduct their specialized functions that help to preserve the integrity of the genome.	Iron	54-58	helicase for meiosis 1	Homo sapiens	97-105
22573437-2	2012	Similarly, the unwinding of double-stranded DNA or RNA by helicases can be studied in ensemble experiments by monitoring either the kinetics of the conversion of the double-stranded nucleic acid into its complementary single strands by the helicase or the kinetics of ATP hydrolysis by the helicase during unwinding.	Adenosine Triphosphate	268-271	helicase for meiosis 1	Homo sapiens	58-66
22293206-0	2012	Fluoroquinolones inhibit HCV by targeting its helicase.	Fluoroquinolones	0-16	helicase for meiosis 1	Homo sapiens	46-54
22293206-4	2012	Fluoroquinolones have also been shown to have inhibitory activity against certain viruses, possibly by targeting the viral helicase.	Fluoroquinolones	0-16	helicase for meiosis 1	Homo sapiens	123-131
22293206-5	2012	To tease out the mechanism of the antiviral activity of fluoroquinolones, their effect on HCV NS3 helicase protein was also tested.	Fluoroquinolones	56-72	helicase for meiosis 1	Homo sapiens	98-106
22293206-11	2012	The inhibition of HCV NS3 helicase activity was also observed with all 12 of the fluoroquinolones.	Fluoroquinolones	81-97	helicase for meiosis 1	Homo sapiens	26-34
22293206-12	2012	CONCLUSIONS: Fluoroquinolones inhibit HCV replication possibly by targeting the HCV NS3 helicase.	Fluoroquinolones	13-29	helicase for meiosis 1	Homo sapiens	88-96
22918583-1	2012	In eukaryotes, the Mcm2-7 complex forms the core of the replicative helicase - the molecular motor that uses ATP binding and hydrolysis to fuel the unwinding of double-stranded DNA at the replication fork.	Adenosine Triphosphate	109-112	helicase for meiosis 1	Homo sapiens	68-76
22675465-0	2012	Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.	g4 oligonucleotide	19-37	helicase for meiosis 1	Homo sapiens	58-66
22701618-4	2012	The helicase unwinds such DNA junctions with a step-size of approximately four bases per ATP hydrolyzed.	Adenosine Triphosphate	89-92	helicase for meiosis 1	Homo sapiens	4-12
22457622-9	2012	After passaging, rescued viruses had acquired single amino acid substitutions (SAAS) within NS3 helicase subdomain 3.	saas	79-83	helicase for meiosis 1	Homo sapiens	96-104
21925774-4	2011	Among those, 3-iodobenzyloxy-substituted derivative 5e showed the most potent activity against HCV (EC(50) = 4 muM) as well as SCV (IC(50) = 4 muM for ATPase activity, 11 muM for helicase activity) and this might be used as a platform structure for future development of the multi-target or broad-spectrum antivirals.	3-iodobenzyloxy	13-28	helicase for meiosis 1	Homo sapiens	179-187
21134131-2	2011	In the present study, we show that all bananin-resistant variants exhibit mutations in helicase and membrane protein, although no evidence of bananin interference on their mutual interaction has been found.	bananin	39-46	helicase for meiosis 1	Homo sapiens	87-95
21947008-6	2011	Here, to understand the synergy between the helicase and the RD for RNA binding, and the contribution of ATP hydrolysis to RIG-I activation, we determined the structure of human RIG-I helicase-RD in complex with dsRNA and an ATP analogue.	Adenosine Triphosphate	105-108	helicase for meiosis 1	Homo sapiens	184-192
21947008-6	2011	Here, to understand the synergy between the helicase and the RD for RNA binding, and the contribution of ATP hydrolysis to RIG-I activation, we determined the structure of human RIG-I helicase-RD in complex with dsRNA and an ATP analogue.	Adenosine Triphosphate	225-228	helicase for meiosis 1	Homo sapiens	184-192
21440839-0	2011	Effects of mercury on the structure and activity of BLM642-1290 recombinant helicase.	Mercury	11-18	helicase for meiosis 1	Homo sapiens	76-84
21440839-5	2011	METHODS: The effects of Hg(2+) on biological activity and structure of BLM642-1290 recombinant helicase were determined by fluorescence polarized, ultraviolet spectroscopic, and free-phosphorus assay technologies, respectively.	Phosphorus	183-193	helicase for meiosis 1	Homo sapiens	95-103
21440839-7	2011	The LMCT (ligand-to-metal charge transition) peaks of the helicase were enhanced with the increase of the Hg(2+) level.	lmct	4-8	helicase for meiosis 1	Homo sapiens	58-66
21440839-7	2011	The LMCT (ligand-to-metal charge transition) peaks of the helicase were enhanced with the increase of the Hg(2+) level.	Metals	20-25	helicase for meiosis 1	Homo sapiens	58-66
21440839-9	2011	CONCLUSION: The biological activity of BLM642-1290 recombinant helicase is inhibited by Hg(2+) treatment.	blm642	39-45	helicase for meiosis 1	Homo sapiens	63-71
21220316-3	2011	A small molecule from the National Cancer Institute Diversity Set designated NSC 19630 [1-(propoxymethyl)-maleimide] was identified that inhibited WRN helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia group J (FANCJ), RECQ1, RecQ, UvrD, or DnaB).	1-(propoxymethyl)maleimide	88-115	helicase for meiosis 1	Homo sapiens	151-159
27516903-3	2011	Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.	benzotriazole	75-88	helicase for meiosis 1	Homo sapiens	264-272
27516903-3	2011	Recently, by in vitro screening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging to Flaviviridae, Coronaviridae, and Picornaviridae families.	Tropolone	178-187	helicase for meiosis 1	Homo sapiens	264-272
20880703-2	2011	Exploiting our previous knowledge in the development of nucleotide-mimicking NS3 helicase (NS3h) inhibitors endowed with key structural and electronic features necessary for an optimal ligand-enzyme interaction, we developed the tetrahydroacridinyl derivative 3a as the most potent NS3h competitive inhibitor reported to date (HCV NS3h K(i)=20 nM).	tetrahydroacridinyl	229-248	helicase for meiosis 1	Homo sapiens	81-89
20880703-2	2011	Exploiting our previous knowledge in the development of nucleotide-mimicking NS3 helicase (NS3h) inhibitors endowed with key structural and electronic features necessary for an optimal ligand-enzyme interaction, we developed the tetrahydroacridinyl derivative 3a as the most potent NS3h competitive inhibitor reported to date (HCV NS3h K(i)=20 nM).	ns3h	91-95	helicase for meiosis 1	Homo sapiens	81-89
21134131-4	2011	The S259/L mutation of SARS-CoV helicase is always found in all the identified bananin-resistant variants, suggesting a primary role of this mutation site for bananin activity.	bananin	79-86	helicase for meiosis 1	Homo sapiens	32-40
21134131-4	2011	The S259/L mutation of SARS-CoV helicase is always found in all the identified bananin-resistant variants, suggesting a primary role of this mutation site for bananin activity.	bananin	159-166	helicase for meiosis 1	Homo sapiens	32-40
21134131-6	2011	The S/L substitution causes a pocket volume reduction that weakens the interaction between bananin and SARS-CoV mutated helicase, suggesting a possible mechanism for bananin antiviral activity.	bananin	91-98	helicase for meiosis 1	Homo sapiens	120-128
21134131-6	2011	The S/L substitution causes a pocket volume reduction that weakens the interaction between bananin and SARS-CoV mutated helicase, suggesting a possible mechanism for bananin antiviral activity.	bananin	166-173	helicase for meiosis 1	Homo sapiens	120-128
20818755-0	2010	A graphene-based platform for the assay of duplex-DNA unwinding by helicase.	Graphite	2-10	helicase for meiosis 1	Homo sapiens	67-75
20887735-4	2010	The unwinding activity slows the movement of the helicase in a sequence-dependent manner, lowering the average unwinding efficiency to less than 1 bp per ATP cycle.	Adenosine Triphosphate	154-157	helicase for meiosis 1	Homo sapiens	49-57
20887735-5	2010	When bound with ATP, the NS3 helicase can display significant translocational diffusion.	Adenosine Triphosphate	16-19	helicase for meiosis 1	Homo sapiens	29-37
21105691-6	2010	The structures of Bu(4)N(+) salts of trans-2, mer-3, and fac-3 were determined using X-ray crystallography.	bu(4)n(+)	18-27	helicase for meiosis 1	Homo sapiens	46-51
21078962-3	2010	Conversely, HepA-related protein (HARP) protein (also known as SMARCAL1 and DNA-dependent ATPase A) is an annealing helicase that rewinds DNA in an ATP-dependent manner.	Adenosine Triphosphate	90-93	helicase for meiosis 1	Homo sapiens	116-124
20669935-8	2010	Helicase activity required a 3"-single-stranded overhang on the third strand and was dependent on ATP hydrolysis.	Adenosine Triphosphate	98-101	helicase for meiosis 1	Homo sapiens	0-8
32313315-0	2010	A Graphene-Based Platform for the Assay of Duplex-DNA Unwinding by Helicase.	Graphite	2-10	helicase for meiosis 1	Homo sapiens	67-75
20447876-5	2010	WRN missense mutations in helicase or RecQ C-terminal domains interfered with the ability of WRN to rescue rad50 MMS sensitivity.	Methyl Methanesulfonate	113-116	helicase for meiosis 1	Homo sapiens	26-34
19451148-5	2009	The requirements of ATP and Mg for the helicase activity were different from those for the ATPase activity.	Adenosine Triphosphate	20-23	helicase for meiosis 1	Homo sapiens	39-47
20167273-3	2010	Reagentless biosensors, binding proteins that are labeled with a fluorophore, target products of the helicase reaction, namely ADP, inorganic phosphate or single-stranded DNA, and can be used to measure rates of product formation with little interference to the system.	Adenosine Diphosphate	127-130	helicase for meiosis 1	Homo sapiens	101-109
20167273-3	2010	Reagentless biosensors, binding proteins that are labeled with a fluorophore, target products of the helicase reaction, namely ADP, inorganic phosphate or single-stranded DNA, and can be used to measure rates of product formation with little interference to the system.	Phosphates	132-151	helicase for meiosis 1	Homo sapiens	101-109
20167273-5	2010	The methods are described in terms of PcrA, a bacterial DNA helicase that moves in single base steps along either single-stranded or double-stranded DNA, hydrolyzing one ATP per base moved.	Adenosine Triphosphate	170-173	helicase for meiosis 1	Homo sapiens	60-68
20167274-4	2010	Synthetic oligonucleotides site-specifically labeled with either Cy3 or Cy5 can be used to create a variety of DNA substrates that can be used to characterized DNA binding, as well as helicase translocation and unwinding.	Oligonucleotides	10-26	helicase for meiosis 1	Homo sapiens	184-192
20167274-4	2010	Synthetic oligonucleotides site-specifically labeled with either Cy3 or Cy5 can be used to create a variety of DNA substrates that can be used to characterized DNA binding, as well as helicase translocation and unwinding.	cy3	65-68	helicase for meiosis 1	Homo sapiens	184-192
20167274-4	2010	Synthetic oligonucleotides site-specifically labeled with either Cy3 or Cy5 can be used to create a variety of DNA substrates that can be used to characterized DNA binding, as well as helicase translocation and unwinding.	cyanine dye 5	72-75	helicase for meiosis 1	Homo sapiens	184-192
19817549-3	2009	This technology uses the helicase"s capability to disrupt the hydrogen bonds of a Watson-Crick base pair in order to separate dsDNA.	Hydrogen	62-70	helicase for meiosis 1	Homo sapiens	25-33
20363755-2	2010	The helicase separates the strands of DNA and RNA duplexes using the energy from ATP hydrolysis.	Adenosine Triphosphate	81-84	helicase for meiosis 1	Homo sapiens	4-12
20363755-3	2010	To understand how ATP hydrolysis is coupled to helicase movement, we measured the single turnover helicase translocation-dissociation kinetics and the pre-steady-state P(i) release kinetics on single-stranded RNA and DNA substrates of different lengths.	Adenosine Triphosphate	18-21	helicase for meiosis 1	Homo sapiens	47-55
20363755-6	2010	The HCV helicase steps on the RNA or DNA one nucleotide at a time, and due to imperfect coupling, not every ATP hydrolysis event produces a successful step.	Adenosine Triphosphate	108-111	helicase for meiosis 1	Homo sapiens	8-16
20363755-10	2010	These effects of the protease domain on the helicase can be explained by an improved allosteric cross-talk between the ATP- and nucleic acid-binding sites achieved by the overall stabilization of the helicase domain structure.	Adenosine Triphosphate	119-122	helicase for meiosis 1	Homo sapiens	44-52
20363755-10	2010	These effects of the protease domain on the helicase can be explained by an improved allosteric cross-talk between the ATP- and nucleic acid-binding sites achieved by the overall stabilization of the helicase domain structure.	Adenosine Triphosphate	119-122	helicase for meiosis 1	Homo sapiens	200-208
20071563-11	2010	Helicase mutant II, with substitutions in the Mg(2+) binding motif II (DEAP to AAAP), showed 50% ATPase activity.	magnesium ion	46-52	helicase for meiosis 1	Homo sapiens	0-8
20071563-11	2010	Helicase mutant II, with substitutions in the Mg(2+) binding motif II (DEAP to AAAP), showed 50% ATPase activity.	2,2-diethoxyacetophenone	71-75	helicase for meiosis 1	Homo sapiens	0-8
20071563-11	2010	Helicase mutant II, with substitutions in the Mg(2+) binding motif II (DEAP to AAAP), showed 50% ATPase activity.	aaap	79-83	helicase for meiosis 1	Homo sapiens	0-8
19879832-3	2009	By analyzing crystal structures in complexes with RNA and ATP analogs, Thomsen and Berger (2009) now elucidate the molecular basis for unidirectional motion by the hexameric RNA helicase Rho.	Adenosine Triphosphate	58-61	helicase for meiosis 1	Homo sapiens	178-186
19451148-5	2009	The requirements of ATP and Mg for the helicase activity were different from those for the ATPase activity.	Magnesium	28-30	helicase for meiosis 1	Homo sapiens	39-47
19620285-0	2009	The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.	Methyl Methanesulfonate	136-159	helicase for meiosis 1	Homo sapiens	74-82
19620285-7	2009	These results strongly suggest for the first time that an Mcm helicase acts as a checkpoint sensor for methyl methanesulfonate-induced DNA damage through direct binding to the replication checkpoint mediator Mrc1.	Methyl Methanesulfonate	103-126	helicase for meiosis 1	Homo sapiens	62-70
19306876-0	2009	The effect of 2-deoxy-D-glucose on Werner syndrome RecQ helicase gene.	Deoxyglucose	14-31	helicase for meiosis 1	Homo sapiens	56-64
19306876-3	2009	In this study, we examined the changes of telomerase and Werner"s syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres.	Deoxyglucose	116-119	helicase for meiosis 1	Homo sapiens	86-94
19306876-3	2009	In this study, we examined the changes of telomerase and Werner"s syndrome RecQ (WRN) helicase after treatment with 2DG, because of the involvement of recQ helicase in the regulation of telomeres.	Deoxyglucose	116-119	helicase for meiosis 1	Homo sapiens	156-164
18951948-0	2009	Regulation of the biochemical function of motif VI of HCV NTPase/helicase by the conserved Phe-loop.	Phenylalanine	91-94	helicase for meiosis 1	Homo sapiens	65-73
19185595-3	2009	The NS3h helicase activity was dependent on the presence of NTP and divalent cations, with a preference for ATP and Mn(2+), and required the substrates possessing a 3" un-base-paired region on the RNA template strand.	Adenosine Triphosphate	108-111	helicase for meiosis 1	Homo sapiens	9-17
19185595-3	2009	The NS3h helicase activity was dependent on the presence of NTP and divalent cations, with a preference for ATP and Mn(2+), and required the substrates possessing a 3" un-base-paired region on the RNA template strand.	Manganese(2+)	116-122	helicase for meiosis 1	Homo sapiens	9-17
19150342-1	2009	We have developed a novel high-throughput screening assay of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase inhibitors using the fluorescence-quenching phenomenon via photoinduced electron transfer between fluorescent dyes and guanine bases.	Guanine	243-250	helicase for meiosis 1	Homo sapiens	115-123
19150342-3	2009	When dsDNA is unwound by helicase, the dye emits fluorescence owing to its release from the guanine bases.	Guanine	92-99	helicase for meiosis 1	Homo sapiens	25-33
19153239-0	2009	The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase.	Adenosine Triphosphate	59-62	helicase for meiosis 1	Homo sapiens	85-93
19153239-5	2009	Here we show that NS4A enhances the ability of NS3hel to bind RNA in the presence of ATP, thereby acting as a cofactor for helicase activity.	Adenosine Triphosphate	85-88	helicase for meiosis 1	Homo sapiens	123-131
19563117-3	2009	They use energy derived from the hydrolysis of nucleotide triphosphates for both bond breakage between complementary bases and translocation of a helicase enzyme along DNA.	nucleotide triphosphates	47-71	helicase for meiosis 1	Homo sapiens	146-154
18497749-1	2008	The ring-shaped T7 helicase uses the energy of dTTP hydrolysis to perform the mechanical work of translocation and base pair (bp) separation.	thymidine 5'-triphosphate	47-51	helicase for meiosis 1	Homo sapiens	19-27
18497749-7	2008	T7 helicase therefore adjusts both its speed and coupling ratio (bp/dTTP) to match the work of DNA unwinding.	thymidine 5'-triphosphate	68-72	helicase for meiosis 1	Homo sapiens	3-11
18299638-8	2008	CONCLUSIONS: By measuring the relative inhibitory concentrations required to overcome particular mutations in the helicase and primase proteins, evidence was obtained that BAY 57-1293 interacts with both components of the helicase-primase complex to achieve maximum potency, whereas for BILS 22BS, this may not be the case.	pritelivir	172-183	helicase for meiosis 1	Homo sapiens	114-122
18620531-3	2008	In the latter case, helicase activity is coupled with NTPase and is stimulated by ATP.	Adenosine Triphosphate	82-85	helicase for meiosis 1	Homo sapiens	20-28
18620531-6	2008	These compounds were studied as inhibitors of the helicase reaction, and it was shown that imidodiphosphate efficiently inhibited the ATP-dependent helicase reaction and had almost no effect on the ATP-independent duplex unwinding.	imidodiphosphonic acid	91-107	helicase for meiosis 1	Homo sapiens	50-58
18620531-6	2008	These compounds were studied as inhibitors of the helicase reaction, and it was shown that imidodiphosphate efficiently inhibited the ATP-dependent helicase reaction and had almost no effect on the ATP-independent duplex unwinding.	imidodiphosphonic acid	91-107	helicase for meiosis 1	Homo sapiens	148-156
18620531-6	2008	These compounds were studied as inhibitors of the helicase reaction, and it was shown that imidodiphosphate efficiently inhibited the ATP-dependent helicase reaction and had almost no effect on the ATP-independent duplex unwinding.	Adenosine Triphosphate	134-137	helicase for meiosis 1	Homo sapiens	50-58
18620531-6	2008	These compounds were studied as inhibitors of the helicase reaction, and it was shown that imidodiphosphate efficiently inhibited the ATP-dependent helicase reaction and had almost no effect on the ATP-independent duplex unwinding.	Adenosine Triphosphate	134-137	helicase for meiosis 1	Homo sapiens	148-156
18620531-7	2008	However, the inhibitory effect of 2 -deoxythymidine 5 -phosphoryl-beta,gamma-hypophosphate was insignificant in both cases, which is due to the possibility of helicase activation by this ATP analog.	Adenosine Triphosphate	187-190	helicase for meiosis 1	Homo sapiens	159-167
18299638-8	2008	CONCLUSIONS: By measuring the relative inhibitory concentrations required to overcome particular mutations in the helicase and primase proteins, evidence was obtained that BAY 57-1293 interacts with both components of the helicase-primase complex to achieve maximum potency, whereas for BILS 22BS, this may not be the case.	pritelivir	172-183	helicase for meiosis 1	Homo sapiens	222-230
18201743-5	2008	Mutation analyses revealed that all of the residues in the Walker A motif (Gly(199), Lys(200) and Thr(201)), in addition to the polar residues within the NTP-binding pocket (Gln(457), Arg(461) and Arg(464)), and also Arg(458) in the outside of the pocket in the motif IV were crucial for ATPase and helicase activities and virus replication.	Arginine	184-187	helicase for meiosis 1	Homo sapiens	299-307
18029358-2	2008	The archaeal Rad3 (xeroderma pigmentosum group D protein (XPD)) helicase is a prototypical member of the Rad3 family, distinct from other related (superfamily II) SF2 enzymes because of a unique insertion containing an iron-sulfur (FeS) cluster.	ferrous sulfide	219-230	helicase for meiosis 1	Homo sapiens	64-72
18267969-3	2008	Here the role of a conserved lysine residue in the smaller tier or collar of the E1 helicase domain in ori processing is described.	Lysine	29-35	helicase for meiosis 1	Homo sapiens	84-92
18039921-2	2008	Therefore, our studies centered on a viral protein, the NS3 helicase, whose activity is indispensable for replication of the viral RNA, and on its peptide inhibitor that corresponds to a highly conserved arginine-rich sequence of domain 2 of the helicase.	Arginine	204-212	helicase for meiosis 1	Homo sapiens	246-254
18029358-0	2008	The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double-stranded DNA junction.	Iron	4-8	helicase for meiosis 1	Homo sapiens	48-56
18029358-0	2008	The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double-stranded DNA junction.	Adenosine Triphosphate	74-77	helicase for meiosis 1	Homo sapiens	48-56
18029358-2	2008	The archaeal Rad3 (xeroderma pigmentosum group D protein (XPD)) helicase is a prototypical member of the Rad3 family, distinct from other related (superfamily II) SF2 enzymes because of a unique insertion containing an iron-sulfur (FeS) cluster.	Iron	232-235	helicase for meiosis 1	Homo sapiens	64-72
18029358-7	2008	Additionally, we observed specific quenching of the Cy5 fluorescent dye when the FeS cluster of a bound helicase is positioned in close proximity to a Cy5 fluorophore incorporated into the DNA molecule.	cyanine dye 5	52-55	helicase for meiosis 1	Homo sapiens	104-112
18029358-7	2008	Additionally, we observed specific quenching of the Cy5 fluorescent dye when the FeS cluster of a bound helicase is positioned in close proximity to a Cy5 fluorophore incorporated into the DNA molecule.	cyanine dye 5	151-154	helicase for meiosis 1	Homo sapiens	104-112
17562711-5	2007	We demonstrated that UAP56 is an ATP-dependent RNA helicase that can unwind substrates with 5" or 3" overhangs or blunt ends in vitro.	Adenosine Triphosphate	33-36	helicase for meiosis 1	Homo sapiens	51-59
18213401-5	2008	Both thermal and GuHCl-induced unfolding experiments confirmed the multidomain organization of the helicase.	guhcl	17-22	helicase for meiosis 1	Homo sapiens	99-107
17503741-0	2007	Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones.	Fluoroquinolones	67-83	helicase for meiosis 1	Homo sapiens	46-54
17373706-1	2007	Hepatitis C virus NS3 helicase is an enzyme that unwinds double-stranded polynucleotides in an ATP-dependent reaction.	Polynucleotides	73-88	helicase for meiosis 1	Homo sapiens	22-30
17373706-1	2007	Hepatitis C virus NS3 helicase is an enzyme that unwinds double-stranded polynucleotides in an ATP-dependent reaction.	Adenosine Triphosphate	95-98	helicase for meiosis 1	Homo sapiens	22-30
17550887-0	2007	Detection of HSV-1 variants highly resistant to the helicase-primase inhibitor BAY 57-1293 at high frequency in 2 of 10 recent clinical isolates of HSV-1.	pritelivir	79-90	helicase for meiosis 1	Homo sapiens	52-60
17550887-1	2007	OBJECTIVES: BAY 57-1293 is a helicase-primase inhibitor (HPI) from a new class of antivirals that are highly efficacious in herpes simplex virus (HSV)-1 animal infection models.	pritelivir	12-23	helicase for meiosis 1	Homo sapiens	29-37
17113777-2	2007	The results suggest that phenylglycine might be capable of interacting with the NS3 (protease-helicase/NTPase) in ways not possible for the common P2 proline-based inhibitors.	2-phenylglycine	25-38	helicase for meiosis 1	Homo sapiens	94-102
17503741-2	2007	Inhibition of gyrase activity by quinolones involves the interaction of these drugs with the helicase component of bacterial gyrase.	Quinolones	33-43	helicase for meiosis 1	Homo sapiens	93-101
17503741-7	2007	In addition, we found that each of these quinolones was inhibitory to the helicase activity of SV40 large tumour antigen.	Quinolones	41-51	helicase for meiosis 1	Homo sapiens	74-82
17503741-8	2007	CONCLUSIONS: Fluoroquinolones and their derivates may therefore be useful in the treatment and/or prevention of infection by SV40-homologous human DNA viruses that encode helicase activity for their survival.	Fluoroquinolones	13-29	helicase for meiosis 1	Homo sapiens	171-179
17032657-3	2006	We report here two novel activities of both the yeast and human Dna2 helicase/nuclease protein: single strand annealing and ATP-independent strand exchange on short duplexes.	Adenosine Triphosphate	124-127	helicase for meiosis 1	Homo sapiens	69-77
17132162-6	2006	RESULTS: An improved assay to determine helicase directionality was developed that uses a substrate containing biotinylated oligonucleotides.	Oligonucleotides	124-140	helicase for meiosis 1	Homo sapiens	40-48
17132162-9	2006	CONCLUSION: It is shown here that the use of a biotin-streptavidin complex as a helicase substrate improves helicase activity and the determination of helicase directionality.	Biotin	47-53	helicase for meiosis 1	Homo sapiens	80-88
17132162-9	2006	CONCLUSION: It is shown here that the use of a biotin-streptavidin complex as a helicase substrate improves helicase activity and the determination of helicase directionality.	Biotin	47-53	helicase for meiosis 1	Homo sapiens	108-116
17132162-9	2006	CONCLUSION: It is shown here that the use of a biotin-streptavidin complex as a helicase substrate improves helicase activity and the determination of helicase directionality.	Biotin	47-53	helicase for meiosis 1	Homo sapiens	108-116
16950766-10	2006	Use of ATP to activate the helicase function did not aid flap displacement by exchange, suggesting that this is a helicase-independent mechanism of complex dissociation.	Adenosine Triphosphate	7-10	helicase for meiosis 1	Homo sapiens	27-35
16893956-0	2006	Role of ATP hydrolysis in the DNA translocase activity of the bovine papillomavirus (BPV-1) E1 helicase.	Adenosine Triphosphate	8-11	helicase for meiosis 1	Homo sapiens	95-103
17027480-1	2006	The first crystal structure of a ring helicase encircling single-stranded DNA reveals a mechanism for ATP-dependent DNA translocation.	Adenosine Triphosphate	102-105	helicase for meiosis 1	Homo sapiens	38-46
16973432-4	2006	Three absolutely conserved cysteine residues provide ligands for the Fe-S cluster, which is essential for the helicase activity of XPD.	Cysteine	27-35	helicase for meiosis 1	Homo sapiens	110-118
16973432-4	2006	Three absolutely conserved cysteine residues provide ligands for the Fe-S cluster, which is essential for the helicase activity of XPD.	Iron	69-73	helicase for meiosis 1	Homo sapiens	110-118
16973432-6	2006	Clinically relevant mutations in patients with trichothiodystrophy (TTD) and Fanconi anemia disrupt the Fe-S clusters of XPD and FancJ and thereby abolish helicase activity.	Iron	104-108	helicase for meiosis 1	Homo sapiens	155-163
16300943-2	2006	In this report, we show that it is possible to inhibit both the ATPase and the helicase activities of a DNA helicase with dibenzothiepins that bind at its nucleic acid binding site.	Dibenzothiepins	122-137	helicase for meiosis 1	Homo sapiens	79-87
16522649-3	2006	The primary sequence and biochemical analysis suggest that hPif1 is a potential homologue of Escherichia coli RecD, an ATP-dependent 5" to 3" DNA helicase.	Adenosine Triphosphate	119-122	helicase for meiosis 1	Homo sapiens	146-154
16380375-0	2006	Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. RecQ helicases are believed to function in repairing replication forks stalled by DNA damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of damaged DNA, thus permitting repair to occur.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	51-78	helicase for meiosis 1	Homo sapiens	30-38
16380375-3	2006	The results demonstrate that WRN helicase activity is inhibited in a strand-specific manner by BaP DE-dG adducts only when on the translocating strand.	Benzo(a)pyrene	95-98	helicase for meiosis 1	Homo sapiens	33-41
16380375-5	2006	In contrast, helicase activity is only mildly affected by intercalating BaP DE-dA adducts that locally perturb DNA double helical structure.	Benzo(a)pyrene	72-75	helicase for meiosis 1	Homo sapiens	13-21
16474403-2	2006	The mechanism for helicase activity can be studied using oligonucleotide substrates to measure formation of single-stranded (ss) DNA from double-stranded (ds) DNA.	Oligonucleotides	57-72	helicase for meiosis 1	Homo sapiens	18-26
16300943-2	2006	In this report, we show that it is possible to inhibit both the ATPase and the helicase activities of a DNA helicase with dibenzothiepins that bind at its nucleic acid binding site.	Dibenzothiepins	122-137	helicase for meiosis 1	Homo sapiens	108-116
16611118-7	2006	The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.	Adenosine Triphosphate	114-117	helicase for meiosis 1	Homo sapiens	4-12
16611118-7	2006	The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.	Adenosine Triphosphate	114-117	helicase for meiosis 1	Homo sapiens	58-66
16611118-7	2006	The helicase inhibitors discussed here influence rates of helicase-catalyzed DNA (or RNA) unwinding by preventing ATP hydrolysis, nucleic acid binding, nucleic acid release, or by disrupting the interaction of a helicase with a required cofactor.	Adenosine Triphosphate	114-117	helicase for meiosis 1	Homo sapiens	58-66
15917436-9	2005	Replacement of cytosine-guanine pairs with cytosine-inosine pairs in the duplex restored unwinding, suggesting that mammalian Mcm4/6/7 helicase has difficulties in unwinding stably base-paired duplex.	cytosine-inosine	43-59	helicase for meiosis 1	Homo sapiens	135-143
17142233-6	2006	Rep forms a large oligomeric complex and the helicase activity is dependent on the oligomeric conformation ( approximately 24mer).	N,N-DIETHYLBENZAMIDE	0-3	helicase for meiosis 1	Homo sapiens	45-53
16304143-0	2005	Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.	biphenylsulfonacetic acid	0-25	helicase for meiosis 1	Homo sapiens	75-83
16304143-0	2005	Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.	Adenosine Triphosphate	92-95	helicase for meiosis 1	Homo sapiens	75-83
16304143-0	2005	Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.	Tyrosine	144-152	helicase for meiosis 1	Homo sapiens	75-83
16314308-0	2005	Bis-aptazyme sensors for hepatitis C virus replicase and helicase without blank signal.	bis-aptazyme	0-12	helicase for meiosis 1	Homo sapiens	57-65
16314308-7	2005	In addition, a bis-aptazyme of dual functions was designed by inserting both aptamers for HCV replicase and helicase into the stem I and stem III of hammerhead ribozyme, respectively, and it also showed greater sensitivity and specificity for both proteins without blank signal.	bis-aptazyme	15-27	helicase for meiosis 1	Homo sapiens	108-116
15917436-9	2005	Replacement of cytosine-guanine pairs with cytosine-inosine pairs in the duplex restored unwinding, suggesting that mammalian Mcm4/6/7 helicase has difficulties in unwinding stably base-paired duplex.	cytosine-guanine	15-31	helicase for meiosis 1	Homo sapiens	135-143
15697627-4	2005	In active opening, the helicase directly destabilizes the double-stranded nucleic acid (dsNA) to promote opening.	double-stranded	58-73	helicase for meiosis 1	Homo sapiens	23-31
15533938-9	2005	Therefore, S(3)" and in particular the hydrogen bonding potential of Tyr(189) is a specific molecular determinant for MMP-8 triple helicase activity.	Hydrogen	39-47	helicase for meiosis 1	Homo sapiens	131-139
15533938-9	2005	Therefore, S(3)" and in particular the hydrogen bonding potential of Tyr(189) is a specific molecular determinant for MMP-8 triple helicase activity.	Tyrosine	69-72	helicase for meiosis 1	Homo sapiens	131-139
16245647-5	2005	N-alkylation of this benzotriazole compound enhanced inhibitory activity and selectivity towards the helicase activity of HCV NTPase/helicase.	benzotriazole	21-34	helicase for meiosis 1	Homo sapiens	101-109
16245647-5	2005	N-alkylation of this benzotriazole compound enhanced inhibitory activity and selectivity towards the helicase activity of HCV NTPase/helicase.	benzotriazole	21-34	helicase for meiosis 1	Homo sapiens	133-141
16245647-9	2005	Although a number of N(1) and N(2) alkyl derivatives exerted good HCV and WNV helicase inhibitory activity when DNA was used as substrate, the activity was strongly decreased or even disappeared when RNA was used as substrate.	4-(2-(4-isopropylbenzamido)ethoxy)benzoic acid	21-25	helicase for meiosis 1	Homo sapiens	78-86
16245647-9	2005	Although a number of N(1) and N(2) alkyl derivatives exerted good HCV and WNV helicase inhibitory activity when DNA was used as substrate, the activity was strongly decreased or even disappeared when RNA was used as substrate.	n(2) alkyl	30-40	helicase for meiosis 1	Homo sapiens	78-86
15579905-9	2005	We found activation of the helicase by ATP did not alter BLM stimulation of cleavage of unstructured flaps.	Adenosine Triphosphate	39-42	helicase for meiosis 1	Homo sapiens	27-35
15579905-13	2005	Moderate helicase-dependent stimulation was observed with both fixed and equilibrating CTG flaps.	ctg	87-90	helicase for meiosis 1	Homo sapiens	9-17
15528191-1	2005	The eukaryotic translation factor 4A (eIF4A) is a member of DEA(D/H)-box RNA helicase family, a diverse group of proteins that couples ATP hydrolysis to RNA binding and duplex separation.	Adenosine Triphosphate	135-138	helicase for meiosis 1	Homo sapiens	77-85
15697627-4	2005	In active opening, the helicase directly destabilizes the double-stranded nucleic acid (dsNA) to promote opening.	dsna	88-92	helicase for meiosis 1	Homo sapiens	23-31
15585580-5	2004	The structures reveal a unique spatial arrangement of the two conserved helicase domains, and ADP-binding induces significant conformational changes of key residues in the ATP-binding pocket.	Adenosine Diphosphate	94-97	helicase for meiosis 1	Homo sapiens	72-80
15585580-5	2004	The structures reveal a unique spatial arrangement of the two conserved helicase domains, and ADP-binding induces significant conformational changes of key residues in the ATP-binding pocket.	Adenosine Triphosphate	172-175	helicase for meiosis 1	Homo sapiens	72-80
15561143-1	2004	Processive DNA helicases are able to translocate along single-stranded DNA (ssDNA) with biased directionality in a nucleoside triphosphate-dependent reaction, although translocation is not generally sufficient for helicase activity.	[[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	115-138	helicase for meiosis 1	Homo sapiens	15-23
15541341-4	2004	NEO-III-14U was shown to inhibit the NS3 protease activity more efficiently than the original aptamer and, furthermore, to efficiently inhibit the unwinding reaction by NS3 helicase.	neo-iii-14u	0-11	helicase for meiosis 1	Homo sapiens	173-181
15485882-6	2004	The N-terminal helicase domain also specifically unwound fork-structured DNA and Holliday junction DNA in the presence of ATP.	Adenosine Triphosphate	122-125	helicase for meiosis 1	Homo sapiens	15-23
15485237-6	2004	While for neutral clusters, the Si(10) is magic, the extra stability of the Si(11) (+) cluster over the Si(10) (+) and Si(12) (+) bears evidence for the magic behavior of the Si(11) (+) cluster, which is in excellent agreement with the recent experimental observations.	Silicon	76-78	helicase for meiosis 1	Homo sapiens	175-181
15146171-3	2004	Using a series of modified substrates to explore the unwinding mechanism of NPH-II, we observed that the helicase tracks exclusively on the loading strand, where it requires covalent continuity and specifically recognizes the ribose-phosphate backbone.	Ribose	226-232	helicase for meiosis 1	Homo sapiens	105-113
15178332-3	2004	A novel direct fluorometric test of helicase activity with a quenched DNA substrate, 3" labeled with a Cy3 dye and 5" labeled with a Black Hole Quencher, was developed and optimal reaction conditions established.	cy3	103-106	helicase for meiosis 1	Homo sapiens	36-44
15146171-3	2004	Using a series of modified substrates to explore the unwinding mechanism of NPH-II, we observed that the helicase tracks exclusively on the loading strand, where it requires covalent continuity and specifically recognizes the ribose-phosphate backbone.	Phosphates	233-242	helicase for meiosis 1	Homo sapiens	105-113
14561097-0	2003	Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues.	Nucleosides	85-95	helicase for meiosis 1	Homo sapiens	28-36
15266895-8	2004	Recently, some promising new drugs have been discovered; one of these compounds, developed at Bayer HealthCare under the name BAY 57-1293, is a potent HSV helicase primase inhibitor.	pritelivir	126-137	helicase for meiosis 1	Homo sapiens	155-163
12975372-6	2003	The helicase activity has an absolute requirement for hydrolysis of a nucleoside 5"-triphosphate, with UTP being the optimal substrate.	nucleoside 5"-triphosphate	70-96	helicase for meiosis 1	Homo sapiens	4-12
12975372-6	2003	The helicase activity has an absolute requirement for hydrolysis of a nucleoside 5"-triphosphate, with UTP being the optimal substrate.	Uridine Triphosphate	103-106	helicase for meiosis 1	Homo sapiens	4-12
14623116-5	2003	We have analysed full-length and truncated NS3 proteins from Powassan virus (a tick-borne flavivirus) to investigate the role that the Q motif plays in the hydrolysis of ATP by a viral helicase.	Adenosine Triphosphate	170-173	helicase for meiosis 1	Homo sapiens	185-193
14747711-0	2004	Crystallization and preliminary X-ray analysis of the helicase domains of Vasa complexed with RNA and an ATP analogue.	Adenosine Triphosphate	105-108	helicase for meiosis 1	Homo sapiens	54-62
14561097-7	2003	This activating effect underwent further dramatic enhancement (>1000%) by further increases in ATP concentration in the reaction mixture, suggesting that the viral helicase and NTPase reactions are not coupled.	Adenosine Triphosphate	98-101	helicase for meiosis 1	Homo sapiens	167-175
12917423-4	2003	We provide the first quantitative analysis of the polynucleic acid binding and NTPase activities of a Nidovirus helicase, using a high throughput phosphate release assay that will be readily adaptable to the future testing of helicase inhibitors.	polynucleic acid	50-66	helicase for meiosis 1	Homo sapiens	112-120
12881525-0	2003	Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent.	benzo[c]phenanthrene diol epoxide	51-84	helicase for meiosis 1	Homo sapiens	30-38
12881525-2	2003	Here we examined the effect of cis- and trans-opened 3,4-diol 1,2-epoxide (DE) DNA adducts of benzo[c]phenanthrene (BcPh) at N6 of adenine on helicase activity.	benzo(c)phenanthrene	94-114	helicase for meiosis 1	Homo sapiens	142-150
12881525-2	2003	Here we examined the effect of cis- and trans-opened 3,4-diol 1,2-epoxide (DE) DNA adducts of benzo[c]phenanthrene (BcPh) at N6 of adenine on helicase activity.	benzo(c)phenanthrene	116-120	helicase for meiosis 1	Homo sapiens	142-150
12881525-2	2003	Here we examined the effect of cis- and trans-opened 3,4-diol 1,2-epoxide (DE) DNA adducts of benzo[c]phenanthrene (BcPh) at N6 of adenine on helicase activity.	Adenine	131-138	helicase for meiosis 1	Homo sapiens	142-150
12917423-4	2003	We provide the first quantitative analysis of the polynucleic acid binding and NTPase activities of a Nidovirus helicase, using a high throughput phosphate release assay that will be readily adaptable to the future testing of helicase inhibitors.	polynucleic acid	50-66	helicase for meiosis 1	Homo sapiens	226-234
12917423-4	2003	We provide the first quantitative analysis of the polynucleic acid binding and NTPase activities of a Nidovirus helicase, using a high throughput phosphate release assay that will be readily adaptable to the future testing of helicase inhibitors.	Phosphates	146-155	helicase for meiosis 1	Homo sapiens	112-120
12917423-5	2003	All eight common NTPs and dNTPs were hydrolyzed by the SARS helicase in a magnesium-dependent reaction, stimulated by the presence of either single-stranded DNA or RNA.	ntps	17-21	helicase for meiosis 1	Homo sapiens	60-68
12917423-5	2003	All eight common NTPs and dNTPs were hydrolyzed by the SARS helicase in a magnesium-dependent reaction, stimulated by the presence of either single-stranded DNA or RNA.	Parathion	26-31	helicase for meiosis 1	Homo sapiens	60-68
12917423-5	2003	All eight common NTPs and dNTPs were hydrolyzed by the SARS helicase in a magnesium-dependent reaction, stimulated by the presence of either single-stranded DNA or RNA.	Magnesium	74-83	helicase for meiosis 1	Homo sapiens	60-68
12649492-0	2003	RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis.	Adenosine Triphosphate	91-94	helicase for meiosis 1	Homo sapiens	37-45
12851713-1	2003	RNA helicase A (RHA) is a member of ATPase/helicase and regulates the transcription through recruitment of Pol II and/or by ATP dependent mechanisms.	Adenosine Triphosphate	36-39	helicase for meiosis 1	Homo sapiens	4-12
12634355-5	2003	Unlike related proteins, different nucleic acid sequences stimulate ATP hydrolysis by HCV helicase at different maximum rates and with different apparent efficiencies.	Adenosine Triphosphate	68-71	helicase for meiosis 1	Homo sapiens	90-98
12853154-9	2003	Potent and long-lasting antibody response was raised against conserved NS3 regions including "Greek-key" motif of protease, motifs II, V and polynucleotide-binding domains of ATPase/helicase.	Polynucleotides	141-155	helicase for meiosis 1	Homo sapiens	182-190
12718544-0	2003	A bis-alkylating triplex forming oligonucleotide inhibits intracellular reporter gene expression and prevents triplex unwinding due to helicase activity.	triplex forming oligonucleotide	17-48	helicase for meiosis 1	Homo sapiens	135-143
12718544-6	2003	Helicase assays demonstrated that helicase activity can unwind the TFO at the unalkylated end of the triple helix, which may leave the unwound oligonucleotide susceptible to nuclease degradation or ineffective at inhibiting transcription initiation.	tfo	67-70	helicase for meiosis 1	Homo sapiens	0-8
12718544-6	2003	Helicase assays demonstrated that helicase activity can unwind the TFO at the unalkylated end of the triple helix, which may leave the unwound oligonucleotide susceptible to nuclease degradation or ineffective at inhibiting transcription initiation.	tfo	67-70	helicase for meiosis 1	Homo sapiens	34-42
12718544-6	2003	Helicase assays demonstrated that helicase activity can unwind the TFO at the unalkylated end of the triple helix, which may leave the unwound oligonucleotide susceptible to nuclease degradation or ineffective at inhibiting transcription initiation.	Oligonucleotides	143-158	helicase for meiosis 1	Homo sapiens	0-8
12718544-6	2003	Helicase assays demonstrated that helicase activity can unwind the TFO at the unalkylated end of the triple helix, which may leave the unwound oligonucleotide susceptible to nuclease degradation or ineffective at inhibiting transcription initiation.	Oligonucleotides	143-158	helicase for meiosis 1	Homo sapiens	34-42
12413450-3	2002	Effects of two nonhydrolyzable ATP analogs on helicase denaturation were measured as controls using the isothermal denaturation (ITD) assay.	Adenosine Triphosphate	31-34	helicase for meiosis 1	Homo sapiens	46-54
12691532-0	2003	Stimulatory effect of an indirectly attached RNA helicase-recruiting sequence on the suppression of gene expression by antisense oligonucleotides.	Oligonucleotides	129-145	helicase for meiosis 1	Homo sapiens	49-57
12413450-4	2002	Two compounds, 4-(2,4-dimethylphenyl)-2,7,8-trimethyl-4,5-quinolinediamine and 2-phenyl-N-(5-piperazin-1-ylpentyl)quinazolin-4-amine, were identified from screening that inhibited the enzyme and had low micromolar dissociation constants for NS3 helicase in the ITD assay.	4-(2,4-dimethylphenyl)-2,7,8-trimethyl-4,5-quinolinediamine	15-74	helicase for meiosis 1	Homo sapiens	245-253
12413450-4	2002	Two compounds, 4-(2,4-dimethylphenyl)-2,7,8-trimethyl-4,5-quinolinediamine and 2-phenyl-N-(5-piperazin-1-ylpentyl)quinazolin-4-amine, were identified from screening that inhibited the enzyme and had low micromolar dissociation constants for NS3 helicase in the ITD assay.	2-phenyl-n-(5-piperazin-1-ylpentyl)quinazolin-4-amine	79-132	helicase for meiosis 1	Homo sapiens	245-253
12413450-5	2002	Low micromolar affinity of the quinolinediamine to helicase was also confirmed by nuclear magnetic resonance experiments.	quinolinediamine	31-47	helicase for meiosis 1	Homo sapiens	51-59
12413450-6	2002	Unfortunately, isothermal titration calorimetry (ITC) experiments indicated that a more water-soluble analog bound to the 47/23-mer oligonucleotide helicase substrate with low micromolar affinity as did the substituted quinazolinamine.	Water	88-93	helicase for meiosis 1	Homo sapiens	148-156
12413450-6	2002	Unfortunately, isothermal titration calorimetry (ITC) experiments indicated that a more water-soluble analog bound to the 47/23-mer oligonucleotide helicase substrate with low micromolar affinity as did the substituted quinazolinamine.	4-Amino-2-chloro-6,7-dimethoxyquinazoline	219-234	helicase for meiosis 1	Homo sapiens	148-156
11959550-0	2002	Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme.	imidazo[4,5-d]pyridazine nucleosides	20-56	helicase for meiosis 1	Homo sapiens	147-155
12237426-3	2002	A series of cysteines located in the envelope protein and the most important enzymatic domains of the virus helicase/NTPase, methyltransferase and RNA-dependent RNA polymerase were found to be highly conserved.	Cysteine	12-21	helicase for meiosis 1	Homo sapiens	108-116
12206878-5	2002	There are also other inhibitory mechanisms conceivable, which may involve a modulation of the interaction of the enzyme with its RNA substrate, for example, (iv) the competitive inhibition of RNA binding and (v) the inhibition of the unwinding by sterical blockade of the translocation of the NTPase/helicase along the polynucleotide chain.	Polynucleotides	319-333	helicase for meiosis 1	Homo sapiens	300-308
12034714-9	2002	Multiple HCV helicase proteins bind to ssDNA >15 nucleotides in length, with an apparent occluded site of 8-11 nucleotides.	8-11 nucleotides	109-125	helicase for meiosis 1	Homo sapiens	13-21
12162749-0	2002	Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites.	Adenosine Triphosphate	22-25	helicase for meiosis 1	Homo sapiens	29-37
12162749-3	2002	The aim of our study was to characterize from an enzymological point of view the mechanism of interaction of the full-length NS3 protease/helicase with its nucleic acid (NA) and ATP substrates.	Adenosine Triphosphate	178-181	helicase for meiosis 1	Homo sapiens	138-146
12162749-5	2002	Moreover, the observation of a reciprocal influence of both substrates on the kinetics of their interaction with the enzyme suggested that the NS3 helicase works as a dimer which can exist in three functionally different states: (i) an unbound state, with two equivalent low-affinity binding sites for ATP, which shows cooperative high-affinity NA binding; (ii) an ATP-bound state, with two equivalent low-affinity NA binding sites; and (iii) a NA-bound state, with two equivalent high-affinity ATP binding sites.	Adenosine Triphosphate	302-305	helicase for meiosis 1	Homo sapiens	147-155
12162749-5	2002	Moreover, the observation of a reciprocal influence of both substrates on the kinetics of their interaction with the enzyme suggested that the NS3 helicase works as a dimer which can exist in three functionally different states: (i) an unbound state, with two equivalent low-affinity binding sites for ATP, which shows cooperative high-affinity NA binding; (ii) an ATP-bound state, with two equivalent low-affinity NA binding sites; and (iii) a NA-bound state, with two equivalent high-affinity ATP binding sites.	Adenosine Triphosphate	365-368	helicase for meiosis 1	Homo sapiens	147-155
12162749-5	2002	Moreover, the observation of a reciprocal influence of both substrates on the kinetics of their interaction with the enzyme suggested that the NS3 helicase works as a dimer which can exist in three functionally different states: (i) an unbound state, with two equivalent low-affinity binding sites for ATP, which shows cooperative high-affinity NA binding; (ii) an ATP-bound state, with two equivalent low-affinity NA binding sites; and (iii) a NA-bound state, with two equivalent high-affinity ATP binding sites.	Adenosine Triphosphate	365-368	helicase for meiosis 1	Homo sapiens	147-155
11959550-2	2002	In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) virus nucleoside triphosphatase (NTPase)/helicase.	Nucleosides	70-80	helicase for meiosis 1	Homo sapiens	255-263
11959550-5	2002	The nucleoside analogues were nevertheless found to be capable of uncoupling the ATPase and helicase activities of the enzyme by a mechanism operating on the level of the enzyme.	Nucleosides	4-14	helicase for meiosis 1	Homo sapiens	92-100
11959550-6	2002	Thus, in the case of HMC-HO4, the direct interaction with the enzyme caused inhibition of its helicase activity, with a half-maximal inhibitory concentration of 30 microM.	1-(2'-O-methylribofuranosyl)imidazo(4,5-d)pyridazine-4,7(5H,6H)-dione	21-28	helicase for meiosis 1	Homo sapiens	94-102
11959550-8	2002	Comparative studies performed with the related NTPase/helicase from hepatitis C virus revealed that the extent of the effects mediated by imidazo[4,5-d]pyridazine nucleosides is enzyme specific.	imidazo[4,5-d]pyridazine nucleosides	138-174	helicase for meiosis 1	Homo sapiens	54-62
11735402-6	2001	Here, we show that trisubstituted acridine ligands are potent inhibitors of the helicase activity of the BLM and WRN proteins on both G-quadruplex and B-form DNA substrates.	Acridines	34-42	helicase for meiosis 1	Homo sapiens	80-88
11927945-2	2002	To target this disease in a new way, we have identified and optimized selective thiazolylphenyl-containing inhibitors of the herpes simplex virus (HSV) helicase-primase enzyme.	thiazolylphenyl	80-95	helicase for meiosis 1	Homo sapiens	152-160
11832483-5	2002	Helicase-primase acts on these joint molecules to promote ATP-dependent branch migration.	Adenosine Triphosphate	58-61	helicase for meiosis 1	Homo sapiens	0-8
11781105-0	2002	Direct measurement of single-stranded DNA translocation by PcrA helicase using the fluorescent base analogue 2-aminopurine.	2-Aminopurine	109-122	helicase for meiosis 1	Homo sapiens	64-72
11781105-1	2002	Use of the fluorescent base analogue 2-aminopurine has provided a direct demonstration of the translocation of PcrA helicase toward the 5"-end of single-stranded DNA.	2-Aminopurine	37-50	helicase for meiosis 1	Homo sapiens	116-124
11781105-4	2002	A full kinetic model is presented for ATP-dependent DNA translocation by PcrA helicase.	Adenosine Triphosphate	38-41	helicase for meiosis 1	Homo sapiens	78-86
11238848-7	2001	Further analysis using guanine and O(6)-benzoylguanine derivatives revealed that the ATPase activity of WN virus NTPase/helicase may be modulated, i.e., increased or reduced, with no effect on the helicase activity of the enzyme.	Guanine	23-30	helicase for meiosis 1	Homo sapiens	120-128
11559795-8	2001	Two further mutations, one in motif VI (R457A,R458A) and the other a clustered charged-to-alanine substitution at R(376)KNGK(380), abolished helicase activity only.	Alanine	90-97	helicase for meiosis 1	Homo sapiens	141-149
11238848-7	2001	Further analysis using guanine and O(6)-benzoylguanine derivatives revealed that the ATPase activity of WN virus NTPase/helicase may be modulated, i.e., increased or reduced, with no effect on the helicase activity of the enzyme.	o(6)-benzoylguanine	35-54	helicase for meiosis 1	Homo sapiens	120-128
11697897-0	2001	Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.	[[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	70-93	helicase for meiosis 1	Homo sapiens	29-37
11697897-0	2001	Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step.	[[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	70-93	helicase for meiosis 1	Homo sapiens	131-139
11697897-4	2001	We have performed an extensive analysis of the substrate specificities of both NS3 NTPase and helicase activities with respect to all four dNTPs as well as with dideoxynucleoside triphoshate (ddNTP) analogs, including both d-(beta) and l-(beta)-deoxy and dideoxy-nucleoside triphosphates.	dntps	139-144	helicase for meiosis 1	Homo sapiens	94-102
11697897-4	2001	We have performed an extensive analysis of the substrate specificities of both NS3 NTPase and helicase activities with respect to all four dNTPs as well as with dideoxynucleoside triphoshate (ddNTP) analogs, including both d-(beta) and l-(beta)-deoxy and dideoxy-nucleoside triphosphates.	dideoxynucleoside triphoshate	161-190	helicase for meiosis 1	Homo sapiens	94-102
11697897-4	2001	We have performed an extensive analysis of the substrate specificities of both NS3 NTPase and helicase activities with respect to all four dNTPs as well as with dideoxynucleoside triphoshate (ddNTP) analogs, including both d-(beta) and l-(beta)-deoxy and dideoxy-nucleoside triphosphates.	ddntp	192-197	helicase for meiosis 1	Homo sapiens	94-102
11697897-4	2001	We have performed an extensive analysis of the substrate specificities of both NS3 NTPase and helicase activities with respect to all four dNTPs as well as with dideoxynucleoside triphoshate (ddNTP) analogs, including both d-(beta) and l-(beta)-deoxy and dideoxy-nucleoside triphosphates.	d-(beta) and l-(beta)-deoxy and dideoxy-nucleoside triphosphates	223-287	helicase for meiosis 1	Homo sapiens	94-102
11697897-7	2001	On the contrary, the helicase activity had more strict substrate selectivity, since, among d-(beta)-nucleotides, only ddTTP and its analog 2",3"-didehydro-thymidine triphosphate could be used as substrates with an efficiency comparable to ATP, whereas among l-(beta)-nucleotides, only l-(beta)-dATP was utilised.	d-(beta)-nucleotides	91-111	helicase for meiosis 1	Homo sapiens	21-29
11697897-7	2001	On the contrary, the helicase activity had more strict substrate selectivity, since, among d-(beta)-nucleotides, only ddTTP and its analog 2",3"-didehydro-thymidine triphosphate could be used as substrates with an efficiency comparable to ATP, whereas among l-(beta)-nucleotides, only l-(beta)-dATP was utilised.	2",3"-didehydro-thymidine triphosphate	139-177	helicase for meiosis 1	Homo sapiens	21-29
11697897-7	2001	On the contrary, the helicase activity had more strict substrate selectivity, since, among d-(beta)-nucleotides, only ddTTP and its analog 2",3"-didehydro-thymidine triphosphate could be used as substrates with an efficiency comparable to ATP, whereas among l-(beta)-nucleotides, only l-(beta)-dATP was utilised.	Adenosine Triphosphate	239-242	helicase for meiosis 1	Homo sapiens	21-29
11697897-7	2001	On the contrary, the helicase activity had more strict substrate selectivity, since, among d-(beta)-nucleotides, only ddTTP and its analog 2",3"-didehydro-thymidine triphosphate could be used as substrates with an efficiency comparable to ATP, whereas among l-(beta)-nucleotides, only l-(beta)-dATP was utilised.	l-(beta)-nucleotides	258-278	helicase for meiosis 1	Homo sapiens	21-29
11697897-7	2001	On the contrary, the helicase activity had more strict substrate selectivity, since, among d-(beta)-nucleotides, only ddTTP and its analog 2",3"-didehydro-thymidine triphosphate could be used as substrates with an efficiency comparable to ATP, whereas among l-(beta)-nucleotides, only l-(beta)-dATP was utilised.	2'-Deoxy-beta-L-adenosine	285-298	helicase for meiosis 1	Homo sapiens	21-29
11697897-8	2001	Comparison of the steady-state kinetic parameters for both reactions, suggested that dATP, l-(beta)-dCTP and l-(beta)-dTTP, specifically reduced a rate limiting step present in the helicase, but not in the NTPase, reaction pathway.	2'-deoxyadenosine triphosphate	85-89	helicase for meiosis 1	Homo sapiens	181-189
11697897-8	2001	Comparison of the steady-state kinetic parameters for both reactions, suggested that dATP, l-(beta)-dCTP and l-(beta)-dTTP, specifically reduced a rate limiting step present in the helicase, but not in the NTPase, reaction pathway.	3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	91-104	helicase for meiosis 1	Homo sapiens	181-189
11697897-8	2001	Comparison of the steady-state kinetic parameters for both reactions, suggested that dATP, l-(beta)-dCTP and l-(beta)-dTTP, specifically reduced a rate limiting step present in the helicase, but not in the NTPase, reaction pathway.	l-(beta)-dttp	109-122	helicase for meiosis 1	Homo sapiens	181-189
11697897-9	2001	These results suggest that NS3-associated NTPase and helicase activities have different sensitivities towards different classes of deoxy and dideoxy-nucleoside analogs, depending on a specific step in the reaction, as well as show different enantioselectivity for the d-(beta) and l-(beta)-conformations of the sugar ring.	oxytocin, 1-desamino-(O-Et-Tyr)(2)-	131-136	helicase for meiosis 1	Homo sapiens	53-61
11697897-9	2001	These results suggest that NS3-associated NTPase and helicase activities have different sensitivities towards different classes of deoxy and dideoxy-nucleoside analogs, depending on a specific step in the reaction, as well as show different enantioselectivity for the d-(beta) and l-(beta)-conformations of the sugar ring.	Dideoxynucleosides	141-159	helicase for meiosis 1	Homo sapiens	53-61
11697897-9	2001	These results suggest that NS3-associated NTPase and helicase activities have different sensitivities towards different classes of deoxy and dideoxy-nucleoside analogs, depending on a specific step in the reaction, as well as show different enantioselectivity for the d-(beta) and l-(beta)-conformations of the sugar ring.	Sugars	311-316	helicase for meiosis 1	Homo sapiens	53-61
11507224-3	2001	We now show interaction between Zta and the helicase (BBLF4) and map the binding region to within amino acids (aa) 22 to 86 of the Zta activation domain.	zta	32-35	helicase for meiosis 1	Homo sapiens	44-52
11507224-3	2001	We now show interaction between Zta and the helicase (BBLF4) and map the binding region to within amino acids (aa) 22 to 86 of the Zta activation domain.	zta	131-134	helicase for meiosis 1	Homo sapiens	44-52
11507224-11	2001	Cells transfected with Zta variants that were defective for helicase binding still formed replication compartments, but Zta was excluded from these compartments.	zta	23-26	helicase for meiosis 1	Homo sapiens	60-68
11551790-0	2001	A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies.	Adenosine Triphosphate	23-26	helicase for meiosis 1	Homo sapiens	61-69
11181034-0	2001	Biotin-streptavidin-labeled oligonucleotides as probes of helicase mechanisms.	Biotin	0-6	helicase for meiosis 1	Homo sapiens	58-66
11181034-0	2001	Biotin-streptavidin-labeled oligonucleotides as probes of helicase mechanisms.	Oligonucleotides	28-44	helicase for meiosis 1	Homo sapiens	58-66
11181034-7	2001	Several applications of oligonucleotides labeled with biotin-streptavidin for the study of helicase mechanisms are described.	Oligonucleotides	24-40	helicase for meiosis 1	Homo sapiens	91-99
11181034-7	2001	Several applications of oligonucleotides labeled with biotin-streptavidin for the study of helicase mechanisms are described.	Biotin	54-60	helicase for meiosis 1	Homo sapiens	91-99
10924124-0	2000	Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N"-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand.	N,N'-bis(2-1(piperidino)-ethyl)-3,4,9,10-perylene-tetracarboxylic diimide	87-159	helicase for meiosis 1	Homo sapiens	59-67
12836307-5	2001	NEO-III-14U was able to inhibit the unwinding of duplex DNA catalyzed by the Full-NS3 helicase activity as well as the protease activity in vitro.	neo-iii-14u	0-11	helicase for meiosis 1	Homo sapiens	86-94
11833782-1	2001	In the presented study the ribavirin-TP--an established inhibitor of the NTPase activity of the superfamily NTPase/helicases II--was investigated as an inhibitor of the unwinding activity of the hepatitis C virus (HCV) NTPase/helicase.	ribavirin 5'-triphosphate	27-39	helicase for meiosis 1	Homo sapiens	115-123
11833782-2	2001	The kinetics of the reaction revealed that ribavirin-TP reduces the turnover number of the helicase reaction by a mechanism that does not correspond to that of the inhibition of the NTPase activity.	ribavirin 5'-triphosphate	43-55	helicase for meiosis 1	Homo sapiens	91-99
10924124-4	2000	In this report, we present data demonstrating that PIPER prevents the unwinding of G-quadruplex structures by yeast Sgs1 helicase.	N,N'-bis(2-1(piperidino)-ethyl)-3,4,9,10-perylene-tetracarboxylic diimide	51-56	helicase for meiosis 1	Homo sapiens	121-129
10769077-7	2000	Finally, our analysis of NS3 processive unwinding under single cycle conditions by addition of heparin in both helicase and RNA-stimulated ATPase assays led to two conclusions: (i) NS3-associated helicase acts processively; (ii) most of the NS3 RNA-stimulated ATPase activity may not be directly coupled to translocation of the enzyme along the substrate RNA molecule.	Heparin	95-102	helicase for meiosis 1	Homo sapiens	196-204
10899133-1	2000	DNA footprinting and nuclease protection studies of PcrA helicase complexed with a 3"-tailed DNA duplex reveal a contact region that covers a significant region of the substrate both in the presence and absence of a non-hydrolysable analogue of ATP, ADPNP.	Adenosine Triphosphate	245-248	helicase for meiosis 1	Homo sapiens	57-65
10899133-1	2000	DNA footprinting and nuclease protection studies of PcrA helicase complexed with a 3"-tailed DNA duplex reveal a contact region that covers a significant region of the substrate both in the presence and absence of a non-hydrolysable analogue of ATP, ADPNP.	adpnp	250-255	helicase for meiosis 1	Homo sapiens	57-65
10819984-1	2000	HCV helicase [E(wt)] catalyzed strand separation of a short DNA duplex (F21:HF31) formed from a 5"-hexachlorofluorescein-tagged 31-mer (HF31) and a 3"-fluorescein-tagged 21-mer (F21) complementary to the 5"-end of HF31.	5"-hexachlorofluorescein	96-120	helicase for meiosis 1	Homo sapiens	4-12
10819984-1	2000	HCV helicase [E(wt)] catalyzed strand separation of a short DNA duplex (F21:HF31) formed from a 5"-hexachlorofluorescein-tagged 31-mer (HF31) and a 3"-fluorescein-tagged 21-mer (F21) complementary to the 5"-end of HF31.	3"-fluorescein	148-162	helicase for meiosis 1	Homo sapiens	4-12
10819984-8	2000	The dissociation constants of HCV helicase for F21, HF31, and F21:HF31 in the absence of Mg(2+) were 0.6 +/- 0.4, 6 +/- 1, and 7.3 +/- 0.9 nM, respectively.	Magnesium	89-91	helicase for meiosis 1	Homo sapiens	34-42
10819984-10	2000	hE(wt) and E(wt) bound F21 and HF31 with similar affinities and had similar ATP-dependent helicase activities, whereas hE(V432A) bound F21 and HF31 with affinities similar to that of E(wt) but had greatly reduced ATP-dependent helicase activities.	Adenosine Triphosphate	76-79	helicase for meiosis 1	Homo sapiens	90-98
10092010-5	1999	Helicase and NTPase activities were dependent on Mg2+ and ATP and inhibited by monovalent cations.	magnesium ion	49-53	helicase for meiosis 1	Homo sapiens	0-8
10961691-0	2000	ATP-binding domain of NTPase/helicase as a target for hepatitis C antiviral therapy.	Adenosine Triphosphate	0-3	helicase for meiosis 1	Homo sapiens	29-37
10961691-1	2000	To enhance the inhibitory potential of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) vs hepatitis C virus (HCV) NTPase/helicase, ribavirin-5"-triphosphate (ribavirin-TP) was synthesized and investigated.	Ribavirin	39-90	helicase for meiosis 1	Homo sapiens	137-145
10592661-3	2000	The elucidation of the atomic structure of the HCV NS3 helicase in complex with oligonucleotide and with ADP has helped clarify our understanding of potential sites for inhibitor binding.	Oligonucleotides	80-95	helicase for meiosis 1	Homo sapiens	55-63
10592661-3	2000	The elucidation of the atomic structure of the HCV NS3 helicase in complex with oligonucleotide and with ADP has helped clarify our understanding of potential sites for inhibitor binding.	Adenosine Diphosphate	105-108	helicase for meiosis 1	Homo sapiens	55-63
10583365-0	1999	Biochemical properties of a minimal functional domain with ATP-binding activity of the NTPase/helicase of hepatitis C virus.	Adenosine Triphosphate	59-62	helicase for meiosis 1	Homo sapiens	94-102
10583365-11	1999	Kinetic experiments with the NTPase/helicase indicate that both compounds inhibit the NTPase activity of the holoenzyme by interacting with its ATP-binding domain.	Adenosine Triphosphate	144-147	helicase for meiosis 1	Homo sapiens	36-44
10683763-3	1999	The exonuclease and helicase activities respond reciprocally to changes in ATP concentrations: Nuclease activity is inhibited at the ATP concentrations that are optimal for the helicase.	Adenosine Triphosphate	133-136	helicase for meiosis 1	Homo sapiens	177-185
10482574-3	1999	In the present study, we further characterized the AAV Rep68/78 helicase, ATPase, and endonuclease activities by using a maltose binding protein-Rep68 fusion (MBP-Rep68Delta) produced in Escherichia coli cells and Rep78 produced in vitro in a rabbit reticulocyte lysate system.	Maltose	121-128	helicase for meiosis 1	Homo sapiens	64-72
10482574-6	1999	We then determined the ATP concentration needed for optimal MBP-Rep68Delta helicase activity and showed that the helicase is active over a wide range of ATP concentrations.	Adenosine Triphosphate	23-26	helicase for meiosis 1	Homo sapiens	75-83
10482574-6	1999	We then determined the ATP concentration needed for optimal MBP-Rep68Delta helicase activity and showed that the helicase is active over a wide range of ATP concentrations.	Adenosine Triphosphate	23-26	helicase for meiosis 1	Homo sapiens	113-121
10482574-6	1999	We then determined the ATP concentration needed for optimal MBP-Rep68Delta helicase activity and showed that the helicase is active over a wide range of ATP concentrations.	Adenosine Triphosphate	153-156	helicase for meiosis 1	Homo sapiens	75-83
10482574-6	1999	We then determined the ATP concentration needed for optimal MBP-Rep68Delta helicase activity and showed that the helicase is active over a wide range of ATP concentrations.	Adenosine Triphosphate	153-156	helicase for meiosis 1	Homo sapiens	113-121
10743562-5	2000	We demonstrate here that the helicase activity of the Sgs1 is important for most elements of the sgs1 mutation phenotype, including sensitivity to UVC, 4-NQO, H2O2, MMS and hydroxyurea.	4-Nitroquinoline-1-oxide	152-157	helicase for meiosis 1	Homo sapiens	29-37
10743562-5	2000	We demonstrate here that the helicase activity of the Sgs1 is important for most elements of the sgs1 mutation phenotype, including sensitivity to UVC, 4-NQO, H2O2, MMS and hydroxyurea.	Hydrogen Peroxide	159-163	helicase for meiosis 1	Homo sapiens	29-37
10683763-3	1999	The exonuclease and helicase activities respond reciprocally to changes in ATP concentrations: Nuclease activity is inhibited at the ATP concentrations that are optimal for the helicase.	Adenosine Triphosphate	75-78	helicase for meiosis 1	Homo sapiens	20-28
10683763-3	1999	The exonuclease and helicase activities respond reciprocally to changes in ATP concentrations: Nuclease activity is inhibited at the ATP concentrations that are optimal for the helicase.	Adenosine Triphosphate	75-78	helicase for meiosis 1	Homo sapiens	177-185
10683763-3	1999	The exonuclease and helicase activities respond reciprocally to changes in ATP concentrations: Nuclease activity is inhibited at the ATP concentrations that are optimal for the helicase.	Adenosine Triphosphate	133-136	helicase for meiosis 1	Homo sapiens	20-28
10092010-5	1999	Helicase and NTPase activities were dependent on Mg2+ and ATP and inhibited by monovalent cations.	Adenosine Triphosphate	58-61	helicase for meiosis 1	Homo sapiens	0-8
9765394-6	1998	Interaction between Zta and the components of the helicase-primase complex was tested by examining the ability of Zta to alter the intracellular localization of these proteins.	zta	20-23	helicase for meiosis 1	Homo sapiens	50-58
9765394-15	1998	The helicase-primase interaction is consistent with a role for Zta in stabilizing the formation of an origin-bound replication complex.	zta	63-66	helicase for meiosis 1	Homo sapiens	4-12
9822692-4	1998	The Mg2+ dependence was a reflection of both the requirement for ICP8 for helicase activity and the ability of ICP8 to reverse the helicase reaction as a consequence of its capacity to anneal homologous single strands at Mg2+ concentrations in excess of 3 mM.	magnesium ion	4-8	helicase for meiosis 1	Homo sapiens	74-82
9822692-4	1998	The Mg2+ dependence was a reflection of both the requirement for ICP8 for helicase activity and the ability of ICP8 to reverse the helicase reaction as a consequence of its capacity to anneal homologous single strands at Mg2+ concentrations in excess of 3 mM.	magnesium ion	4-8	helicase for meiosis 1	Homo sapiens	131-139
9822692-4	1998	The Mg2+ dependence was a reflection of both the requirement for ICP8 for helicase activity and the ability of ICP8 to reverse the helicase reaction as a consequence of its capacity to anneal homologous single strands at Mg2+ concentrations in excess of 3 mM.	magnesium ion	221-225	helicase for meiosis 1	Homo sapiens	131-139
9765394-6	1998	Interaction between Zta and the components of the helicase-primase complex was tested by examining the ability of Zta to alter the intracellular localization of these proteins.	zta	114-117	helicase for meiosis 1	Homo sapiens	50-58
9765394-8	1998	This relocalization provides evidence for an interaction between Zta and the helicase and Zta and the primase subcomplex.	zta	65-68	helicase for meiosis 1	Homo sapiens	77-85
9765394-11	1998	Evidence for interaction between oriLyt bound Zta and the helicase-primase complex was obtained in a superactivation assay using an oriLyt-chloramphenicol acetyltransferase (CAT) reporter.	orilyt	33-39	helicase for meiosis 1	Homo sapiens	58-66
9765394-11	1998	Evidence for interaction between oriLyt bound Zta and the helicase-primase complex was obtained in a superactivation assay using an oriLyt-chloramphenicol acetyltransferase (CAT) reporter.	zta	46-49	helicase for meiosis 1	Homo sapiens	58-66
9765394-13	1998	Cotransfection of the helicase-primase proteins, one of which was fused to a heterologous activation domain, led to Zta-dependent superactivation of CAT expression.	zta	116-119	helicase for meiosis 1	Homo sapiens	22-30
9657115-8	1998	The anti-NS3 (ATPase/helicase) reactivity decreased on denaturation by sodium dodecyl sulfate (SDS) and beta-mercaptoethanol (2ME), suggesting the recognition of nonlinear or conformational B-cell determinants.	Sodium Dodecyl Sulfate	71-93	helicase for meiosis 1	Homo sapiens	21-29
9657115-8	1998	The anti-NS3 (ATPase/helicase) reactivity decreased on denaturation by sodium dodecyl sulfate (SDS) and beta-mercaptoethanol (2ME), suggesting the recognition of nonlinear or conformational B-cell determinants.	Sodium Dodecyl Sulfate	95-98	helicase for meiosis 1	Homo sapiens	21-29
9657115-8	1998	The anti-NS3 (ATPase/helicase) reactivity decreased on denaturation by sodium dodecyl sulfate (SDS) and beta-mercaptoethanol (2ME), suggesting the recognition of nonlinear or conformational B-cell determinants.	Mercaptoethanol	104-124	helicase for meiosis 1	Homo sapiens	21-29
9305914-5	1997	The present study revealed that both ATPase activity and DNA helicase activity that displaces oligonucleotides annealed to single-stranded circular DNA are associated with an MCM protein complex.	Oligonucleotides	94-110	helicase for meiosis 1	Homo sapiens	61-69
9605426-0	1998	Anthracycline antibiotic blockade of SV40 T antigen helicase action.	Anthracyclines	0-13	helicase for meiosis 1	Homo sapiens	52-60
9605426-1	1998	We previously showed that anthracycline antibiotics potently block SV40 large T antigen helicase; in the present study, we describe the kinetics and the structure-activity characteristics of this process.	Anthracyclines	26-39	helicase for meiosis 1	Homo sapiens	88-96
9605426-2	1998	The concentration vs effect data for helicase blockade were fitted by the Hill equation to yield nearly parallel log-concentration effect curves for a series of active anthracycline antibiotics.	Anthracyclines	168-181	helicase for meiosis 1	Homo sapiens	37-45
9605426-3	1998	The effective concentration for 50% helicase blockade (EC50) values ranged from 0.34 microM for daunorubicin to 40.8 microM for 3"-deaminodaunorubicin.	Daunorubicin	96-108	helicase for meiosis 1	Homo sapiens	36-44
9605426-3	1998	The effective concentration for 50% helicase blockade (EC50) values ranged from 0.34 microM for daunorubicin to 40.8 microM for 3"-deaminodaunorubicin.	3"-deaminodaunorubicin	128-150	helicase for meiosis 1	Homo sapiens	36-44
9605426-5	1998	The Hill constants for the blockade ranged from 1.1 to 1.6 for the entire series of active anthracyclines, indicating no positive cooperativity and suggesting that a single molecule of bound drug is sufficient to block helicase action.	Anthracyclines	91-105	helicase for meiosis 1	Homo sapiens	219-227
9605426-7	1998	The kinetics of the blockade indicated that the anthracycline, DNA, and helicase form a ternary complex that is irreversible under the reaction conditions.	Anthracyclines	48-61	helicase for meiosis 1	Homo sapiens	72-80
9605426-8	1998	This mechanism may be central to the cytotoxic and anti-cancer activities of anthracycline antibiotics and may be useful in understanding the enzymatic mechanism of DNA helicase action.	Anthracyclines	77-90	helicase for meiosis 1	Homo sapiens	169-177
9461305-5	1997	High concentrations of ATP are required for the helicase activity but are inhibitory to the RNA-folding activity.	Adenosine Triphosphate	23-26	helicase for meiosis 1	Homo sapiens	48-56
9461305-6	1997	Mg2+ is required for the helicase activity but not for the RNA-folding reaction.	magnesium ion	0-4	helicase for meiosis 1	Homo sapiens	25-33
9305914-8	1997	Displacement of DNA fragments by the DNA helicase suggested that it migrated along single-stranded DNA in the 3" to 5" direction, and the DNA helicase activity was detected only in the presence of hydrolyzable ATP or dATP.	Adenosine Triphosphate	210-213	helicase for meiosis 1	Homo sapiens	142-150
9305914-8	1997	Displacement of DNA fragments by the DNA helicase suggested that it migrated along single-stranded DNA in the 3" to 5" direction, and the DNA helicase activity was detected only in the presence of hydrolyzable ATP or dATP.	2'-deoxyadenosine triphosphate	217-221	helicase for meiosis 1	Homo sapiens	41-49
9305914-8	1997	Displacement of DNA fragments by the DNA helicase suggested that it migrated along single-stranded DNA in the 3" to 5" direction, and the DNA helicase activity was detected only in the presence of hydrolyzable ATP or dATP.	2'-deoxyadenosine triphosphate	217-221	helicase for meiosis 1	Homo sapiens	142-150
9016557-1	1997	We describe a novel activity of the SV40 large T-ag helicase, the unwinding of four stranded DNA structures linked by stacked G-quartets, namely stacked groups of four guanine bases bound by Hoogsteen hydrogen bonds.	Guanine	168-175	helicase for meiosis 1	Homo sapiens	52-60
9223530-3	1997	The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolished by a His-Ala point mutation, leaving a fully functional nucleoside triphosphatase.	Histidine	106-109	helicase for meiosis 1	Homo sapiens	21-29
9223530-3	1997	The integrity of the helicase function is dependent on the conserved DEAD motif and can be abolished by a His-Ala point mutation, leaving a fully functional nucleoside triphosphatase.	Alanine	110-113	helicase for meiosis 1	Homo sapiens	21-29
9094652-0	1997	Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells.	Polynucleotides	0-14	helicase for meiosis 1	Homo sapiens	74-82
9094652-7	1997	The protein was used to examine the effects of polynucleotides on the NTPase, helicase, and protease activities.	Polynucleotides	47-62	helicase for meiosis 1	Homo sapiens	78-86
9020191-0	1997	Biochemical analyses of mutations in the HSV-1 helicase-primase that alter ATP hydrolysis, DNA unwinding, and coupling between hydrolysis and unwinding.	Adenosine Triphosphate	75-78	helicase for meiosis 1	Homo sapiens	47-55
9016557-1	1997	We describe a novel activity of the SV40 large T-ag helicase, the unwinding of four stranded DNA structures linked by stacked G-quartets, namely stacked groups of four guanine bases bound by Hoogsteen hydrogen bonds.	Hydrogen	201-209	helicase for meiosis 1	Homo sapiens	52-60
9016557-2	1997	The structures unwound by the helicase were of two types: (i) quadruplexes comprising four parallel strands that were generated by annealing oligonucleotides including clustered G residues in a buffer containing Na+ions.	Oligonucleotides	141-157	helicase for meiosis 1	Homo sapiens	30-38
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	Adenosine Triphosphate	50-53	helicase for meiosis 1	Homo sapiens	0-8
8642695-1	1996	Vaccinia virus RNA helicase (NPH-II) catalyzes nucleoside triphosphate-dependent unwinding of duplex RNAs containing a single-stranded 3" RNA tail.	[[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate	47-70	helicase for meiosis 1	Homo sapiens	19-27
8022830-5	1994	Unwinding of this substrate by the T4 dda helicase restores the fluorescence of the 2-aminopurines and is easily followed using stopped-flow or steady-state fluorescence spectroscopy.	2-Aminopurine	84-98	helicase for meiosis 1	Homo sapiens	42-50
8790942-1	1996	We showed that DNA-dependent ATPase Q1 (DNA helicase Q1) from xeroderma pigmentosum complementation group C (XP-C) cells elutes from FPLC Mono Q column at higher concentrations of KCl than that from other human cells (35).	Potassium Chloride	180-183	helicase for meiosis 1	Homo sapiens	44-52
8627691-0	1996	The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.	Adenosine Triphosphate	90-93	helicase for meiosis 1	Homo sapiens	58-66
8628658-4	1996	Incubation with the T-ag helicase caused unwinding of the d(TC)(20) tract and consequent release of the oligonucleotide, while the plasmid molecules remained double-stranded.	Oligonucleotides	104-119	helicase for meiosis 1	Homo sapiens	25-33
7947840-4	1994	Therefore, an enhancement of fluorescein fluorescence (lambda ex = 492 nm; lambda em = 520 nm) occurs upon helicase-catalyzed unwinding of the duplex DNA and separation of the complementary strands.	Fluorescein	29-40	helicase for meiosis 1	Homo sapiens	107-115
8505308-3	1993	The helicase binds stably to the tailed RNA in the absence of any cofactor; strand displacement by the bound protein is coupled to NTP hydrolysis.	ntp	131-134	helicase for meiosis 1	Homo sapiens	4-12
8387516-6	1993	The stimulation by SSBs was nonspecific; all SSBs tested, such as human SSB, bacteriophage T4 gene 32, and Escherichia coli SSB, stimulated the DNA helicase activity to a varying extent in the presence of a fork structure.	Sudan Black B	19-23	helicase for meiosis 1	Homo sapiens	148-156
8387516-9	1993	DNA helicase activity required ATP hydrolysis and could be supported by all eight nucleoside triphosphates.	Adenosine Triphosphate	31-34	helicase for meiosis 1	Homo sapiens	4-12
8387516-9	1993	DNA helicase activity required ATP hydrolysis and could be supported by all eight nucleoside triphosphates.	nucleoside triphosphates	82-106	helicase for meiosis 1	Homo sapiens	4-12
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	2'-deoxyadenosine triphosphate	57-61	helicase for meiosis 1	Homo sapiens	0-8
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	Cytidine Triphosphate	88-91	helicase for meiosis 1	Homo sapiens	0-8
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	2'-deoxycytidine 5'-triphosphate	93-97	helicase for meiosis 1	Homo sapiens	0-8
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	Uridine Triphosphate	102-105	helicase for meiosis 1	Homo sapiens	0-8
1429725-7	1992	A helicase capable of unwinding a 34-mer oligonucleotide, annealed to a complementary sequence in single-stranded M13, also copurified with the mismatch-binding protein.	Oligonucleotides	41-56	helicase for meiosis 1	Homo sapiens	2-10
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	Glycyrrhizic Acid	0-12	helicase for meiosis 1	Homo sapiens	107-115
1719376-9	1991	Thus, we conclude that helicase complexes that are formed in the absence of ATP on duplex RNA translocate processively along the RNA in an ATP-dependent reaction and melt secondary structure.	Adenosine Triphosphate	76-79	helicase for meiosis 1	Homo sapiens	23-31
1719376-9	1991	Thus, we conclude that helicase complexes that are formed in the absence of ATP on duplex RNA translocate processively along the RNA in an ATP-dependent reaction and melt secondary structure.	Adenosine Triphosphate	139-142	helicase for meiosis 1	Homo sapiens	23-31
34904824-0	2022	Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis.	Adenosine Triphosphate	61-64	helicase for meiosis 1	Homo sapiens	31-39
34818959-0	2021	Discovery of Zafirlukast as a novel SARS-CoV-2 helicase inhibitor using in silico modelling and a FRET-based assay.	zafirlukast	13-24	helicase for meiosis 1	Homo sapiens	47-55
34818959-2	2021	Structural studies revealed a sulphate moiety that interacts with key residues within the nucleotide-binding site of the helicase.	Sulfates	30-38	helicase for meiosis 1	Homo sapiens	121-129
34818959-9	2021	These results suggest that zafirlukast alleviates SARS-CoV-2 pathogenicity by inhibiting the viral helicase and impairing the viral replication/transcription pathway.	zafirlukast	27-38	helicase for meiosis 1	Homo sapiens	99-107
34455933-4	2021	A unique collection of nucleoside analogs was screened against the SARS-CoV-2 helicase protein, for which a molecular docking experiment was executed to depict the selected ligand"s binding affinity with the SARS-CoV-2 helicase proteins.	Nucleosides	23-33	helicase for meiosis 1	Homo sapiens	78-86
34455933-4	2021	A unique collection of nucleoside analogs was screened against the SARS-CoV-2 helicase protein, for which a molecular docking experiment was executed to depict the selected ligand"s binding affinity with the SARS-CoV-2 helicase proteins.	Nucleosides	23-33	helicase for meiosis 1	Homo sapiens	219-227
34455933-9	2021	Free energy calculation by MM-PBSA and MM-GBSA analysis suggests that pritelivir may work as viable therapeutics for efficient drug advancement against SARS-CoV-2 Nsp13 helicase, potentially arresting the SARS-CoV-2 replication.Communicated by Ramaswamy H. Sarma.	pritelivir	70-80	helicase for meiosis 1	Homo sapiens	169-177
33940460-5	2021	The recombinant nsp13 possessed ATPase and helicase activities for binding and unwinding dsDNA/RNA substrates with 5"-overhangs, and Mg2+ and Mn2+ were critical for its ATPase and helicase activities.	magnesium ion	133-137	helicase for meiosis 1	Homo sapiens	180-188
33940460-5	2021	The recombinant nsp13 possessed ATPase and helicase activities for binding and unwinding dsDNA/RNA substrates with 5"-overhangs, and Mg2+ and Mn2+ were critical for its ATPase and helicase activities.	Manganese(2+)	142-146	helicase for meiosis 1	Homo sapiens	180-188
33940460-7	2021	Site-directed mutagenesis demonstrated that Lys289 (K289) of PEDV nsp13 was essential for its ATPase and helicase activities.	moxonidine	52-56	helicase for meiosis 1	Homo sapiens	105-113
33800013-8	2021	The molecule is often bound to the ATP binding site (referred to as binding site 2) of the helicase enzyme.	Adenosine Triphosphate	35-38	helicase for meiosis 1	Homo sapiens	91-99
34388402-5	2021	Using a combination of drug docking and molecular dynamics simulations, we have identified a list of competitive helicase inhibitors targeting the ATP hydrolysis site and have discovered a potential allosteric site capable of distorting both of the protein"s active sites.	Adenosine Triphosphate	147-150	helicase for meiosis 1	Homo sapiens	113-121
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	helicase for meiosis 1	Homo sapiens	107-115
35422113-4	2022	We observed that fluvastatin and pitavastatin showed fair, binding affinities to RNA polymerase and 3-CL-Pro, whereas fluvastatin showed the strongest binding affinity to the helicase.	Fluvastatin	118-129	helicase for meiosis 1	Homo sapiens	175-183
35462185-10	2022	Acetylcysteine, clavulanic acid and homovanillic acid were identified as potential lead compounds for the SARS-CoV-2 helicase.	Acetylcysteine	0-14	helicase for meiosis 1	Homo sapiens	117-125
35462185-10	2022	Acetylcysteine, clavulanic acid and homovanillic acid were identified as potential lead compounds for the SARS-CoV-2 helicase.	Clavulanic Acid	16-31	helicase for meiosis 1	Homo sapiens	117-125
35462185-10	2022	Acetylcysteine, clavulanic acid and homovanillic acid were identified as potential lead compounds for the SARS-CoV-2 helicase.	Homovanillic Acid	36-53	helicase for meiosis 1	Homo sapiens	117-125
35545850-5	2022	In this study, we performed an in silico screening of common food-derived carotenoids against druggable target proteins of SARS-CoV-2 including main protease, helicase, replication complex, spike protein and its mutants for the recent variants of concern, and ADP-ribose phosphatase.	Carotenoids	74-85	helicase for meiosis 1	Homo sapiens	159-167
35545850-12	2022	Molecular docking experiments against main protease, helicase, replication complex, spike protein and its mutants for the recent variants of concern, and ADP-ribose phosphatase resulted in a few carotenoids with multitarget inhibitory effects.	Carotenoids	195-206	helicase for meiosis 1	Homo sapiens	53-61
35545850-13	2022	Particularly, crocin as one of the main components of saffron exhibited strong binding affinities to the multiple drug targets including main protease, helicase, replication complex, mutant spike protein of lineage B.1.351, and ADP-ribose phosphatase.	crocin	14-20	helicase for meiosis 1	Homo sapiens	152-160
34198322-7	2021	From this, we have identified FPA-124 and several suramin-related compounds as novel inhibitors of nsp13 helicase activity in vitro.	fpa	30-33	helicase for meiosis 1	Homo sapiens	105-113
34198322-7	2021	From this, we have identified FPA-124 and several suramin-related compounds as novel inhibitors of nsp13 helicase activity in vitro.	Suramin	50-57	helicase for meiosis 1	Homo sapiens	105-113
34458837-4	2021	Here, we report two ternary crystal structures of heparan sulfate 3-OST isoform 3 (3-OST-3) with PAP (3"-phosphoadenosine 5"-phosphate) and two octasaccharide substrates: non 6-O-sulfated octasaccharide (8-mer 1) and 6-O-sulfated octasaccharide (8-mer 3).	heparan sulfate 3-ost	50-71	helicase for meiosis 1	Homo sapiens	248-253
34345157-0	2021	Synthesis of Hetaryl-Substituted Asymmetric Porphyrins and Their Affinity to SARS-CoV-2 Helicase.	Porphyrins	44-54	helicase for meiosis 1	Homo sapiens	88-96
34345157-2	2021	Molecular docking of non-symmetric hetaryl-substituted porphyrins and chlorin e6 with SARS-CoV-2 helicase has been carried out.	Porphyrins	55-65	helicase for meiosis 1	Homo sapiens	97-105
34345157-2	2021	Molecular docking of non-symmetric hetaryl-substituted porphyrins and chlorin e6 with SARS-CoV-2 helicase has been carried out.	phytochlorin	70-80	helicase for meiosis 1	Homo sapiens	97-105
34345157-5	2021	Possible ways to inhibit and photoinactivate SARS-CoV helicase have been suggested basing on the localization of porphyrins and chlorin e6 in the helicase domains.	Porphyrins	113-123	helicase for meiosis 1	Homo sapiens	54-62
34345157-5	2021	Possible ways to inhibit and photoinactivate SARS-CoV helicase have been suggested basing on the localization of porphyrins and chlorin e6 in the helicase domains.	Porphyrins	113-123	helicase for meiosis 1	Homo sapiens	146-154
34345157-5	2021	Possible ways to inhibit and photoinactivate SARS-CoV helicase have been suggested basing on the localization of porphyrins and chlorin e6 in the helicase domains.	phytochlorin	128-138	helicase for meiosis 1	Homo sapiens	54-62
34345157-5	2021	Possible ways to inhibit and photoinactivate SARS-CoV helicase have been suggested basing on the localization of porphyrins and chlorin e6 in the helicase domains.	phytochlorin	128-138	helicase for meiosis 1	Homo sapiens	146-154
35017203-7	2022	Thus, the Chl1 helicase affects RPA-dependent checkpoint activation in response to replication fork arrest by ensuring proper intracellular dNTP levels, thereby controlling replication fork progression under replication stress conditions.	Parathion	140-144	helicase for meiosis 1	Homo sapiens	15-23