PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22612714-6	2013	The carnitine, citrate, and formate excretion in urine appeared to be higher in the healthy children, while the NSCL/P group excreted higher concentrations of aspartic acid and phenylalanine in urine.	Aspartic Acid	159-172	nescient helix-loop-helix 1	Homo sapiens	112-116
26540672-4	2016	The aim of the investigation was to replicate previous studies reporting evidence of association between polymorphisms of folate related genes and the occurrence of non-syndromic cleft lip with or without cleft palate (NSCL/P), using three independent samples of different ancestry: from Tibet, Bangladesh and Iran, respectively.	Folic Acid	122-128	nescient helix-loop-helix 1	Homo sapiens	219-223
26215833-8	2016	This study demonstrates that the risk of NSCL/P is associated with variants of the GCH1 gene related to BH4 metabolism and provides some evidence of the relationships between morphological/functional shifts in the central nervous system and orofacial clefts.	sapropterin	104-107	nescient helix-loop-helix 1	Homo sapiens	41-45
25716564-2	2015	Periconceptional intake of folate may reduce the risk of NSCL/P.	Folic Acid	27-33	nescient helix-loop-helix 1	Homo sapiens	57-61
24423009-1	2014	A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.	n-substituted cyanamides	42-66	nescient helix-loop-helix 1	Homo sapiens	169-173
27369588-12	2016	Through DNA sequencing, the authors also identified 2 novel, rare, potentially pathogenic variants (p.Asn323Asp and p.Lys426IlefsTer6) in ARHGAP29 In conclusion, the authors have shown evidence for the association of many loci with NSCL/P and NSCPO.	lys426ilefster6	118-133	nescient helix-loop-helix 1	Homo sapiens	232-236
27387868-1	2016	OBJECTIVE: The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C>T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P).	Folic Acid	69-75	nescient helix-loop-helix 1	Homo sapiens	247-251
27721602-4	2016	AIMS: The aim of this study was to evaluate the Hcy levels in NSCL +- P cases by comparing with control cases having no orofacial deformities.	Homocysteine	48-51	nescient helix-loop-helix 1	Homo sapiens	62-66
27721602-10	2016	There was an increase in Hcy concentration among the NSCL +- P cases with an average value of 18.4 mumol/L.	Homocysteine	25-28	nescient helix-loop-helix 1	Homo sapiens	53-57
27721602-12	2016	CONCLUSIONS: The results of this study indicate that Hcy concentration has a significant elevation in NSCL +- P patients when compared with that of control cases.	Homocysteine	53-56	nescient helix-loop-helix 1	Homo sapiens	102-106
24423009-1	2014	A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.	amidoxime	116-126	nescient helix-loop-helix 1	Homo sapiens	169-173
24423009-1	2014	A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.	benzenesulfonyl chloride	132-157	nescient helix-loop-helix 1	Homo sapiens	169-173
22612714-6	2013	The carnitine, citrate, and formate excretion in urine appeared to be higher in the healthy children, while the NSCL/P group excreted higher concentrations of aspartic acid and phenylalanine in urine.	Phenylalanine	177-190	nescient helix-loop-helix 1	Homo sapiens	112-116
18330265-0	2007	[Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells].	Quercetin	11-20	nescient helix-loop-helix 1	Homo sapiens	86-90
23725631-5	2013	These results support the impact of MTHFR C677T polymorphism and importance of folic acid intake in the etiology of nsCL/P.	Folic Acid	79-89	nescient helix-loop-helix 1	Homo sapiens	116-120
23776525-5	2013	Functional assays support these findings, revealing that NSCL/P cells accumulate DNA double-strand breaks upon exposure to H2O2.	Hydrogen Peroxide	123-127	nescient helix-loop-helix 1	Homo sapiens	57-61
20192358-1	2010	NSCL is currently constructing the ReA3 reaccelerator, which will accelerate rare isotopes obtained from gas stopping of fast-fragment beams to energies of up to 3 MeV/u for uranium and higher for lighter ions.	Uranium	174-181	nescient helix-loop-helix 1	Homo sapiens	0-4
23721485-0	2013	Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkp hen1 RNA repair system.	Phosphates	43-52	nescient helix-loop-helix 1	Homo sapiens	132-136
23692788-8	2012	In conclusion, mothers carrying 677TT genotype or with 677CT/1298AC combined genotype have increased risk of having nsCL/P offspring; therefore, higher periconceptional folic acid supplementation should be advised for decreasing the recurrence risk.	Folic Acid	169-179	nescient helix-loop-helix 1	Homo sapiens	116-120
21205839-0	2011	Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3" terminal RNA ribose 2"O-methyltransferase.	Manganese	67-76	nescient helix-loop-helix 1	Homo sapiens	59-63
20890936-1	2010	BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P).	Folic Acid	56-66	nescient helix-loop-helix 1	Homo sapiens	185-189
20890936-2	2010	The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P.	Folic Acid	159-169	nescient helix-loop-helix 1	Homo sapiens	238-242
20890936-8	2010	CONCLUSION: The findings of the present study suggested that genetic variants of folic acid metabolic genes may modulate maternal susceptibility for having an offspring with NSCL/P.	Folic Acid	81-91	nescient helix-loop-helix 1	Homo sapiens	174-178
18714953-0	2008	An experimental and theoretical study of NSCl decomposition in the presence of trace amounts of water.	Water	96-101	nescient helix-loop-helix 1	Homo sapiens	41-45
18714953-1	2008	An experimental and density functional theory study of the decomposition reaction of NSCl with water molecule(s) into NH 3 and SO 2 is described.	Water	95-100	nescient helix-loop-helix 1	Homo sapiens	85-89
18714953-2	2008	Experiments involving the decomposition of NSCl in the presence of trace amounts of water showed that the formation of both HNSO and SO 2 is faster when the cell and the cell surface are fresh and more likely to be coated in adsorbed water.	Water	84-89	nescient helix-loop-helix 1	Homo sapiens	43-47
18714953-2	2008	Experiments involving the decomposition of NSCl in the presence of trace amounts of water showed that the formation of both HNSO and SO 2 is faster when the cell and the cell surface are fresh and more likely to be coated in adsorbed water.	Water	234-239	nescient helix-loop-helix 1	Homo sapiens	43-47
18714953-4	2008	The barrier for reaction 1 in which NSCl decomposes to form HNSO becomes substantially lower when the explicit hydrogen bonding of water molecules is considered.	Hydrogen	111-119	nescient helix-loop-helix 1	Homo sapiens	36-40
18714953-4	2008	The barrier for reaction 1 in which NSCl decomposes to form HNSO becomes substantially lower when the explicit hydrogen bonding of water molecules is considered.	Water	131-136	nescient helix-loop-helix 1	Homo sapiens	36-40
18714953-5	2008	The water assisted decomposition reaction mechanism can help account for the experimentally observed conversion of NSCl to produce HNSO in the presence of water.	Water	4-9	nescient helix-loop-helix 1	Homo sapiens	115-119
18714953-5	2008	The water assisted decomposition reaction mechanism can help account for the experimentally observed conversion of NSCl to produce HNSO in the presence of water.	hnso	131-135	nescient helix-loop-helix 1	Homo sapiens	115-119
18714953-5	2008	The water assisted decomposition reaction mechanism can help account for the experimentally observed conversion of NSCl to produce HNSO in the presence of water.	Water	155-160	nescient helix-loop-helix 1	Homo sapiens	115-119
18714953-6	2008	The calculated barrier of reaction 2 (the decomposition of HNSO into NH 3 and SO 2) can also explain the experimental observation of SO 2 bands from the decomposition of NSCl in the presence of water.	Water	194-199	nescient helix-loop-helix 1	Homo sapiens	170-174
18563345-0	2008	Effect of quercetin on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells.	Quercetin	10-19	nescient helix-loop-helix 1	Homo sapiens	85-89
18563345-1	2008	The effect of quercetin (Que) on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells was investigated.	Quercetin	14-23	nescient helix-loop-helix 1	Homo sapiens	95-99
18563345-1	2008	The effect of quercetin (Que) on proliferation and apoptosis of human nasopharyngeal carcinoma HEN1 cells was investigated.	Quercetin	25-28	nescient helix-loop-helix 1	Homo sapiens	95-99
18563345-2	2008	Inhibition rate of quercetin on HEN1 was assayed by MTT method, apoptosis by flow cytometry (FCM), and the caspase-3 expression of each group by colorimetry set respectively.	Quercetin	19-28	nescient helix-loop-helix 1	Homo sapiens	32-36
18563345-2	2008	Inhibition rate of quercetin on HEN1 was assayed by MTT method, apoptosis by flow cytometry (FCM), and the caspase-3 expression of each group by colorimetry set respectively.	monooxyethylene trimethylolpropane tristearate	52-55	nescient helix-loop-helix 1	Homo sapiens	32-36
18563345-3	2008	Quercetin inhibited HEN1 cells in in a dose-(r=0.709, P<0.01) and time-dependent manner (r=0.703, P<0.01).	Quercetin	0-9	nescient helix-loop-helix 1	Homo sapiens	20-24
18563345-8	2008	It was concluded that the growth inhibition of quercetin was highly related to cell cycle arrest at the G(2)/M phase and induction of caspase-dependent apoptosis in human nasopharyngeal carcinoma HEN1 cells.	Quercetin	47-56	nescient helix-loop-helix 1	Homo sapiens	196-200
18330265-1	2007	OBJECTIVE: To investigate the effect of quercetin (Que) on HEN1 cells, a kind of human nasopharyngeal carcinoma cells.	Quercetin	40-49	nescient helix-loop-helix 1	Homo sapiens	59-63
18330265-2	2007	METHOD: Inhibition rate of quercetin on HEN1 was assayed by MTT method, cell apoptosis by flow cytometry (FCM), Caspase-3 expression of each group were determined by colorimetry set.	Quercetin	27-36	nescient helix-loop-helix 1	Homo sapiens	40-44
18330265-3	2007	RESULT: The inhibition of quercetin on HEN1 cells was shown in the dose-dependent (r = 0.709, P < 0.05) and time-dependent manner (r = 0.703, P < 0.01).	Quercetin	26-35	nescient helix-loop-helix 1	Homo sapiens	39-43
18330265-8	2007	CONCLUSION: Quercetin can activate the expression of Caspase-3 and induce the apoptosis of HEN1 cells through mitochondrion-depended pathway.	Quercetin	12-21	nescient helix-loop-helix 1	Homo sapiens	91-95
17629209-6	2007	There was a significant increase of patients with NSCL/P in pregnant women exposed to infection, drug intake and folic acid deficiency.	Folic Acid	113-123	nescient helix-loop-helix 1	Homo sapiens	50-54
17629209-9	2007	Infection, drug intake and folic acid supplement during pregnancy were associated with the occurrence of NSCL/P.	Folic Acid	27-37	nescient helix-loop-helix 1	Homo sapiens	105-109
12949372-6	2003	Using the breakpoint of a one-slope broken-line model, the lysine requirement was determined to be 4.88 +/- 0.96 g/kg of diet or 366 +/- 72 mg x hen(-1) x d(-1) with an upper 95% CI of 6.40 g/kg of diet or 480 mg x hen(-1) x d(-1).	Lysine	59-65	nescient helix-loop-helix 1	Homo sapiens	145-151
16170026-4	2005	We show that PX-866, a PI3-K inhibitor with selectivity for p110alpha, potentiates the antitumor activity of gefitinib against even large A-549 NSCL xenografts giving complete tumor growth control in the early stages of treatment.	PX-866	13-19	nescient helix-loop-helix 1	Homo sapiens	144-148
16170026-4	2005	We show that PX-866, a PI3-K inhibitor with selectivity for p110alpha, potentiates the antitumor activity of gefitinib against even large A-549 NSCL xenografts giving complete tumor growth control in the early stages of treatment.	Gefitinib	109-118	nescient helix-loop-helix 1	Homo sapiens	144-148
14755461-12	2004	Previous studies have also found linkage of NS CL/P to 4q31 and 6p23.	Phosphorus	0-1	nescient helix-loop-helix 1	Homo sapiens	44-49
35471549-1	2022	The aims of this study were to assess the association between polymorphisms within genes involved in vitamin B12 transport and nonsyndromic cleft lip with or without cleft palate (NSCL/P) and global DNA methylation in Chile.	Vitamin B 12	101-112	nescient helix-loop-helix 1	Homo sapiens	180-184
8289804-4	1994	HEN1 encodes a 20-kDa polypeptide (pp20HEN1) that is phosphorylated exclusively at serine residues and forms dimeric bHLH complexes either by self-association or by heterologous interaction with the E2A gene products (E12 or E47).	Serine	83-89	nescient helix-loop-helix 1	Homo sapiens	0-4
34289180-1	2021	The aim of this study was to evaluate, in a case-control design, the association between maternal genotypes for variants in 23 genes involved in folate/one-carbon metabolism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a Chilean population.	Folic Acid	145-151	nescient helix-loop-helix 1	Homo sapiens	231-235
34289180-1	2021	The aim of this study was to evaluate, in a case-control design, the association between maternal genotypes for variants in 23 genes involved in folate/one-carbon metabolism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a Chilean population.	Carbon	156-162	nescient helix-loop-helix 1	Homo sapiens	231-235
34578418-1	2021	In plants, HEN1-facilitated methylation at 3" end ribose is a critical step of small-RNA (sRNA) biogenesis.	Ribose	50-56	nescient helix-loop-helix 1	Homo sapiens	11-15
34089806-4	2021	METHODS: For clinical validation, we compared the performance of dPCR and castPCR in 57 NSCL formalin fixed paraffin embedded samples and 10 lung cancer-free formalin fixed paraffin embedded samples.	Formaldehyde	93-101	nescient helix-loop-helix 1	Homo sapiens	88-92
32042737-1	2019	Background: Reduced folate carrier 1 (RFC1) gene is a candidate for susceptibility to nonsyndromic cleft lip with or without cleft palate (NSCL/P).	Folic Acid	20-26	nescient helix-loop-helix 1	Homo sapiens	139-143
32492698-1	2021	BACKGROUND: The S-adenosyl-methionine (SAM) availability is crucial for DNA methylation, an epigenetic mechanism involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression.	S-Adenosylmethionine	16-37	nescient helix-loop-helix 1	Homo sapiens	178-182
32492698-1	2021	BACKGROUND: The S-adenosyl-methionine (SAM) availability is crucial for DNA methylation, an epigenetic mechanism involved in nonsyndromic cleft lip with or without cleft palate (NSCL/P) expression.	S-Adenosylmethionine	39-42	nescient helix-loop-helix 1	Homo sapiens	178-182
32492698-8	2021	IMPACT: SAM synthesis pathway genetic variants are factors associated to NSCL/P.This article adds new evidence for folate related genes in NSCL/P in Chile.Its impact is to contribute with potential new markers for genetic counseling.	Folic Acid	115-121	nescient helix-loop-helix 1	Homo sapiens	73-77
32492698-8	2021	IMPACT: SAM synthesis pathway genetic variants are factors associated to NSCL/P.This article adds new evidence for folate related genes in NSCL/P in Chile.Its impact is to contribute with potential new markers for genetic counseling.	Folic Acid	115-121	nescient helix-loop-helix 1	Homo sapiens	139-143
33967480-2	2020	The aim of this study was to investigate the association between methylenetetrahydrofolate reductase (MTHFR) cytosine-to-thymine (c. 677 C>T), adenine-to-cytosine (c.1298 A>C) single- nucleotide polymorphisms (SNPs) and South Indian patients with the nonsyndromic cleft lip with or without palate (NSCL +- P).	Thymine	121-128	nescient helix-loop-helix 1	Homo sapiens	298-302
33967480-2	2020	The aim of this study was to investigate the association between methylenetetrahydrofolate reductase (MTHFR) cytosine-to-thymine (c. 677 C>T), adenine-to-cytosine (c.1298 A>C) single- nucleotide polymorphisms (SNPs) and South Indian patients with the nonsyndromic cleft lip with or without palate (NSCL +- P).	Adenine	143-150	nescient helix-loop-helix 1	Homo sapiens	298-302
31713293-5	2020	CONCLUSIONS: Owing to the rs1979277 A allele, which reduces the cytoplasmic SHMT activity and has a higher frequency in controls than in NSCL/P cases, we hypothesized that a low enzyme activity may increase the cytoplasmic concentration of folates and, therefore, explain the protective role against OFCs.	Folic Acid	240-247	nescient helix-loop-helix 1	Homo sapiens	137-141
3015372-2	1986	A total of 39 patients with non-small cell carcinoma of the lung (NSCL) were treated with cisplatin, etoposide, and mitomycin.	Cisplatin	90-99	nescient helix-loop-helix 1	Homo sapiens	66-70
3015372-2	1986	A total of 39 patients with non-small cell carcinoma of the lung (NSCL) were treated with cisplatin, etoposide, and mitomycin.	Etoposide	101-110	nescient helix-loop-helix 1	Homo sapiens	66-70
3015372-2	1986	A total of 39 patients with non-small cell carcinoma of the lung (NSCL) were treated with cisplatin, etoposide, and mitomycin.	Mitomycin	116-125	nescient helix-loop-helix 1	Homo sapiens	66-70
33150183-4	2020	ARHGAP29, one of the NSCL/P disease-causing genes, mediates the cyclical regulation of small GTP binding proteins such as RhoA and plays an essential role in cellular shape, proliferation, and craniofacial development.	Guanosine Triphosphate	93-96	nescient helix-loop-helix 1	Homo sapiens	21-25
31933779-1	2019	OBJECTIVE: Non-syndromic cleft lip with or without palate (NSCL/P) is one of the most common congenital birth defects affected by both gene and environmental modifiers.	BPIFB1 protein, human	51-57	nescient helix-loop-helix 1	Homo sapiens	59-63
30881086-2	2019	Several studies suggest that the decrease in folate has been associated with a higher risk of NSCL/P.	Folic Acid	45-51	nescient helix-loop-helix 1	Homo sapiens	94-98
31638429-10	2019	Conclusions: Our findings identified a novel CDH1 variant (c.468G>C/p.Trp156Cys) responsible for NSCL/P in a Chinese family, which expanded the mutational spectrum of the CDH1 gene and may contribute to understanding the molecular basis of NSCL/P.	trp156cys	70-79	nescient helix-loop-helix 1	Homo sapiens	97-101
31638429-10	2019	Conclusions: Our findings identified a novel CDH1 variant (c.468G>C/p.Trp156Cys) responsible for NSCL/P in a Chinese family, which expanded the mutational spectrum of the CDH1 gene and may contribute to understanding the molecular basis of NSCL/P.	trp156cys	70-79	nescient helix-loop-helix 1	Homo sapiens	240-244
30476306-11	2019	VR was 6.3 +- 2.1 m3 h-1 hen-1 for the CO2 balance method, which estimated lower VR values in warm season compared to the laser tachometer (LT) method (-5%) but higher values compared to the HWA method (+5%).	N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide	39-42	nescient helix-loop-helix 1	Homo sapiens	25-30
29356306-6	2018	CONCLUSIONS: Our study illustrated the importance of taking into account potential GxG interaction for genetic association analysis in NSCL/P, and this study suggested both BHMT/BHMT2 and DMGDH should be considered as candidate genes for NSCL/P in future studies.	4-(2,6-difluorophenyl)-2,4-dioxobutanoic acid	83-86	nescient helix-loop-helix 1	Homo sapiens	135-139
29283947-7	2018	There was significantly increased NSCL/P risk with high maternal age (P =0.002), family history (P = 0.001), abortion history (P = 0.033), poor parental education level (P = 0.008), maternal smoking (P = 0.044), maternal alcohol (P = 0.039), common cold or fever (P = 0.035), drug use (P = 0.006), and maternal stress (P = 0.049).	Alcohols	221-228	nescient helix-loop-helix 1	Homo sapiens	34-38
29283947-8	2018	Reduced NSCL/P risk was found with folic acid supplementation (P = 0.005), adequate maternal age (P = 0.002), and high parental education (P = 0.001).	Folic Acid	35-45	nescient helix-loop-helix 1	Homo sapiens	8-12
29283947-9	2018	The proper amount of folic acid, the appropriate age of childbearing, and the high education were the protective factors of NSCL/P, whereas family history, abortion history, drug use during pregnancy, maternal tobacco and alcohol, and maternal stress were the risk factors for NSCL/P in Yantai District, China.	Folic Acid	21-31	nescient helix-loop-helix 1	Homo sapiens	124-128