PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 23518387-5 2013 These changes were accompanied by decreases in TCA flux but an increase in citrate synthase activity, providing substrates for de novo fatty acid and cholesterol synthesis. Fatty Acids 135-145 citrate synthase Mus musculus 75-91 24298268-8 2013 Quantification of enzymatic activities regulating mitochondrial uptake of pyruvate and FA showed an increase of both carnitine-palmitoyltransferase and citrate synthase activities together with a decrease of lactate dehydrogenase and pyruvate dehydrogenase activities. Pyruvic Acid 74-82 citrate synthase Mus musculus 152-168 23518387-5 2013 These changes were accompanied by decreases in TCA flux but an increase in citrate synthase activity, providing substrates for de novo fatty acid and cholesterol synthesis. Cholesterol 150-161 citrate synthase Mus musculus 75-91 23518387-7 2013 Treatment of the MOSE cells with 1.5 muM sphingosine, a bioactive sphingolipid metabolite, decreased citrate synthase activity, increased TCA flux, decreased cholesterol synthesis and glycolysis. Sphingosine 41-52 citrate synthase Mus musculus 101-117 23042511-7 2013 Interestingly, atorvastatin reduced CS activity, a marker for mitochondrial function, in gastrocnemius, diaphragm, and heart, whereas NCX 6560 prevented such decrease. Atorvastatin 15-27 citrate synthase Mus musculus 36-38 23137884-5 2013 When the Krebs cycle and mitochondrial respiratory chain functionality was analysed through the measurement of the citrate synthase and complexes I to IV activity, it showed that their activity was altered in all cases in a similar manner in both infected groups. krebs 9-14 citrate synthase Mus musculus 115-131 21803452-4 2012 A nucleotide variant in exon 3 of Cs is the only known DNA difference within the ahl4 candidate gene interval that is unique to the A/J strain and that causes a nonsynonymous codon change. Cesium 34-36 citrate synthase Mus musculus 81-85 21803452-5 2012 Multiple lines of evidence implicate this missense mutation (H55N) as the underlying cause of ahl4-related hearing loss, likely through its effects on mitochondrial adenosine trisphosphate (ATP) and free radical production in cochlear hair cells. adenosine trisphosphate 165-188 citrate synthase Mus musculus 94-98 21803452-5 2012 Multiple lines of evidence implicate this missense mutation (H55N) as the underlying cause of ahl4-related hearing loss, likely through its effects on mitochondrial adenosine trisphosphate (ATP) and free radical production in cochlear hair cells. Adenosine Triphosphate 190-193 citrate synthase Mus musculus 94-98 21711451-0 2011 Effects of Doxorubicin and Fenofibrate on the activities of NADH oxidase and citrate synthase in mice. Doxorubicin 11-22 citrate synthase Mus musculus 77-93 22485150-3 2012 Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function. Citric Acid 45-56 citrate synthase Mus musculus 0-16 22485150-3 2012 Citrate synthase (CS) is a key enzyme of the citric acid cycle that provides energy for cellular function. Citric Acid 45-56 citrate synthase Mus musculus 18-20 22485150-4 2012 Additionally, CS plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis. Citric Acid 52-59 citrate synthase Mus musculus 14-16 22485150-4 2012 Additionally, CS plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis. Acetyl Coenzyme A 68-78 citrate synthase Mus musculus 14-16 21711451-4 2011 Therefore, we investigated the effects of DOX and fenofibrate on activities of both mitochondrial citrate synthase and NADH oxidase, which are marker enzymes in the tricarboxylic acid (TCA) cycle and a measure of the complex I-III-IV activity in electron transport chain, respectively. Doxorubicin 42-45 citrate synthase Mus musculus 98-114 21711451-4 2011 Therefore, we investigated the effects of DOX and fenofibrate on activities of both mitochondrial citrate synthase and NADH oxidase, which are marker enzymes in the tricarboxylic acid (TCA) cycle and a measure of the complex I-III-IV activity in electron transport chain, respectively. Fenofibrate 50-61 citrate synthase Mus musculus 98-114 21711451-4 2011 Therefore, we investigated the effects of DOX and fenofibrate on activities of both mitochondrial citrate synthase and NADH oxidase, which are marker enzymes in the tricarboxylic acid (TCA) cycle and a measure of the complex I-III-IV activity in electron transport chain, respectively. Tricarboxylic Acids 165-183 citrate synthase Mus musculus 98-114 21711451-4 2011 Therefore, we investigated the effects of DOX and fenofibrate on activities of both mitochondrial citrate synthase and NADH oxidase, which are marker enzymes in the tricarboxylic acid (TCA) cycle and a measure of the complex I-III-IV activity in electron transport chain, respectively. Tricarboxylic Acids 185-188 citrate synthase Mus musculus 98-114 21711451-5 2011 Dox (15 mg/kg) and/or fenofibrate (100 mg/kg/day) were administered to mice for 3 or 14 days, and the activities of citrate synthase and NADH oxidase were measured. Doxorubicin 0-3 citrate synthase Mus musculus 116-132 21711451-6 2011 Our study showed that Dox significantly inhibits the activity of citrate synthase while fenofibrate induces the activity. Doxorubicin 22-25 citrate synthase Mus musculus 65-81 21711451-7 2011 Similar to citrate synthase, NADH oxidase activity was also induced by fenofibrate except in spleen but inhibited by Dox except in the heart and liver. Fenofibrate 71-82 citrate synthase Mus musculus 11-27 21711451-8 2011 Furthermore, fenofibrate not only protects citrate synthase activity from Dox-induced toxicity in the ventricle but also significantly rescues NADH oxidase activity in the kidney. Fenofibrate 13-24 citrate synthase Mus musculus 43-59 21711451-8 2011 Furthermore, fenofibrate not only protects citrate synthase activity from Dox-induced toxicity in the ventricle but also significantly rescues NADH oxidase activity in the kidney. Doxorubicin 74-77 citrate synthase Mus musculus 43-59 22446876-1 2012 We recently demonstrated that fenofibrate induces the activities of citrate synthase and NADH oxidase in cardiac mitochondria. Fenofibrate 30-41 citrate synthase Mus musculus 68-84 22031168-9 2012 KO mice had a modest increase in hepatic oxidative stress, lower expression of mitochondrial superoxide dismutase (SOD2), and lower citrate synthase activity, the first step in the tricarboxylic acid cycle. Tricarboxylic Acids 181-199 citrate synthase Mus musculus 132-148 21711451-0 2011 Effects of Doxorubicin and Fenofibrate on the activities of NADH oxidase and citrate synthase in mice. Fenofibrate 27-38 citrate synthase Mus musculus 77-93 19650862-6 2009 A locus contributing to the early onset, rapidly progressing hearing loss of A/J mice (ahl4, age-related hearing loss 4) was reported to map to chromosome 10 in a region of conserved synteny to DFNB74, suggesting that ahl4 and DFNB74 may be due to mutations of the same gene in these two species. dfnb74 194-200 citrate synthase Mus musculus 87-91 20962926-5 2010 The improvement in whole-body glucose tolerance in the fat-1 mouse was associated with a approximately 21% (p < 0.05) decrease in whole-muscle citrate synthase (CS) activity (in red muscle only), without alterations in CS activity of isolated mitochondria (either red or white muscle; p > 0.05). Glucose 30-37 citrate synthase Mus musculus 146-162 20962926-5 2010 The improvement in whole-body glucose tolerance in the fat-1 mouse was associated with a approximately 21% (p < 0.05) decrease in whole-muscle citrate synthase (CS) activity (in red muscle only), without alterations in CS activity of isolated mitochondria (either red or white muscle; p > 0.05). Glucose 30-37 citrate synthase Mus musculus 164-166 20962926-5 2010 The improvement in whole-body glucose tolerance in the fat-1 mouse was associated with a approximately 21% (p < 0.05) decrease in whole-muscle citrate synthase (CS) activity (in red muscle only), without alterations in CS activity of isolated mitochondria (either red or white muscle; p > 0.05). Glucose 30-37 citrate synthase Mus musculus 222-224 20716647-1 2010 Citrate synthase (CS) is an enzyme of the Krebs cycle that plays a key role in mitochondrial metabolism. krebs 42-47 citrate synthase Mus musculus 0-16 20716647-1 2010 Citrate synthase (CS) is an enzyme of the Krebs cycle that plays a key role in mitochondrial metabolism. krebs 42-47 citrate synthase Mus musculus 18-20 20716647-6 2010 CS from A/J mice also showed lower Michaelis constant (K(m)) for both acetyl CoA and oxaloacetate compared with the other strains of mice. acetyl coa and oxaloacetate 70-97 citrate synthase Mus musculus 0-2 20716647-9 2010 In summary, H55N polymorphism in Cs could be the underlying cause of low CS activity and its high affinity for substrates in A/J mice compared with other strains. Cesium 33-35 citrate synthase Mus musculus 73-75 19861415-4 2010 Exposure of mouse Hepa1-6 cells to 10-30 microm PQQ for 24-48 h resulted in increased citrate synthase and cytochrome c oxidase activity, Mitotracker staining, mitochondrial DNA content, and cellular oxygen respiration. PQQ Cofactor 48-51 citrate synthase Mus musculus 86-102 19650862-6 2009 A locus contributing to the early onset, rapidly progressing hearing loss of A/J mice (ahl4, age-related hearing loss 4) was reported to map to chromosome 10 in a region of conserved synteny to DFNB74, suggesting that ahl4 and DFNB74 may be due to mutations of the same gene in these two species. dfnb74 194-200 citrate synthase Mus musculus 218-222 19059206-4 2009 Fibrinogen can specifically bind to nonnative form of citrate synthase and inhibit its thermal aggregation and inactivation in an ATP-independent manner. Adenosine Triphosphate 130-133 citrate synthase Mus musculus 54-70 17456854-7 2007 The effects of RSG on adipose mitochondrial genes were confirmed by quantitative RT-PCR and further supported by mitochondrial staining, mitochondrial DNA quantification, and citrate synthase activity. Rosiglitazone 15-18 citrate synthase Mus musculus 175-191 17960358-12 2008 The study supports the view that amplification results from the intramitochondrial production of citrate by citrate synthase and from the associated export of citrate into the cytosol. Citric Acid 97-104 citrate synthase Mus musculus 108-124 7723666-5 1995 After anabolic steroid administration, reduced histochemical staining of succinate dehydrogenase was observed in skeletal muscles rich in oxidative type 1 fibers, but it was not different from that of tumor-bearing control animals, which was also confirmed by measurements of citrate synthase and cytochrome c oxidase activities in skeletal muscle and liver tissue. Steroids 15-22 citrate synthase Mus musculus 276-292 15334410-10 2004 Citrate synthase activity was indirectly detected in real time, as [3,4-13C2]glutamate was formed from [2-13C]oxaloacetate and [2-13C]acetate (of acetyl-CoA). [3,4-13c2]glutamate 67-86 citrate synthase Mus musculus 0-16 15334410-10 2004 Citrate synthase activity was indirectly detected in real time, as [3,4-13C2]glutamate was formed from [2-13C]oxaloacetate and [2-13C]acetate (of acetyl-CoA). [2-13c]oxaloacetate 103-122 citrate synthase Mus musculus 0-16 15334410-10 2004 Citrate synthase activity was indirectly detected in real time, as [3,4-13C2]glutamate was formed from [2-13C]oxaloacetate and [2-13C]acetate (of acetyl-CoA). [2-13c]acetate 127-141 citrate synthase Mus musculus 0-16 15334410-10 2004 Citrate synthase activity was indirectly detected in real time, as [3,4-13C2]glutamate was formed from [2-13C]oxaloacetate and [2-13C]acetate (of acetyl-CoA). Acetyl Coenzyme A 146-156 citrate synthase Mus musculus 0-16 8594419-5 1995 Mass-specific activities of phosphofructokinase, citrate synthase, and cytochrome oxidase were significantly lower in SOL from STZ-diabetic mice than in controls by 23, 18, and 36%, respectively. Streptozocin 127-130 citrate synthase Mus musculus 49-65 26300535-14 2015 Citrate synthase activity was significantly decreased in the skeletal muscle of HFD mice, and these decreases were also inhibited by sesamin. sesamin 133-140 citrate synthase Mus musculus 0-16 35631648-6 2022 Placental mitochondrial DNA content, as well as placental expression of cytochrome c-oxidase subunit-II, DNA polymerase gamma, and citrate synthase, was higher in tenofovir/emtricitabine-treated mice compared to other groups. Tenofovir 163-172 citrate synthase Mus musculus 131-147 34648126-11 2021 The activity of TCA cycle enzymes; citrate synthase, aconitase, isocitrate dehydrogenase and fumarase were also altered following MPTP intoxication. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 130-134 citrate synthase Mus musculus 35-51 34807744-8 2021 The expression and desuccinylation activity of Sirt5, lysine succinylation of citrate synthase and ATP synthase subunits were investigated by Western blot, immunohistochemistry, and ELISA in SAH mice and patients. Lysine 54-60 citrate synthase Mus musculus 78-94 34746839-6 2021 Next, we found that lactate administration under calorie restriction enhanced mitochondrial enzyme activity (citrate synthase and succinate dehydrogenase) and the expression of oxidative phosphorylation (OXPHOS) protein expression. Lactic Acid 20-27 citrate synthase Mus musculus 109-125 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Lactic Acid 114-121 citrate synthase Mus musculus 43-59 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Lactic Acid 114-121 citrate synthase Mus musculus 61-63 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Lactic Acid 114-121 citrate synthase Mus musculus 85-87 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Colforsin 193-202 citrate synthase Mus musculus 43-59 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Colforsin 193-202 citrate synthase Mus musculus 61-63 34588991-7 2021 Meanwhile, the intramuscular expression of citrate synthase (CS) and the activity of CS increased after 5weeks of lactate injection (p<0.05), but the change of CS expression was not blocked by forskolin injection, suggesting other mechanisms might exist. Colforsin 193-202 citrate synthase Mus musculus 85-87 34246718-8 2021 Data obtained showed a decrease in mitochondrial density in young adults treated with DOX or MTX and aged control, as assessed by citrate synthase (CS) activity. Doxorubicin 86-89 citrate synthase Mus musculus 130-146 34246718-8 2021 Data obtained showed a decrease in mitochondrial density in young adults treated with DOX or MTX and aged control, as assessed by citrate synthase (CS) activity. Doxorubicin 86-89 citrate synthase Mus musculus 148-150 34246718-8 2021 Data obtained showed a decrease in mitochondrial density in young adults treated with DOX or MTX and aged control, as assessed by citrate synthase (CS) activity. Mitoxantrone 93-96 citrate synthase Mus musculus 130-146 34246718-8 2021 Data obtained showed a decrease in mitochondrial density in young adults treated with DOX or MTX and aged control, as assessed by citrate synthase (CS) activity. Mitoxantrone 93-96 citrate synthase Mus musculus 148-150 35525197-3 2022 CS is a key enzyme in the tricarboxylic acid cycle, which is transported from cytoplasm to mitochondria after synthesis, sorted by the mitochondrial targeting sequence (MTS). Tricarboxylic Acids 26-44 citrate synthase Mus musculus 0-2 35158245-8 2022 HFPO-TA exposure increased protein expression of mitochondrial complex I-V, and the activities of key enzymes involved in TCA cycle (alpha-ketoglutarate dehydrogenase, citrate synthase, and succinate dehydrogenase). hfpo-ta 0-7 citrate synthase Mus musculus 168-184 35631648-6 2022 Placental mitochondrial DNA content, as well as placental expression of cytochrome c-oxidase subunit-II, DNA polymerase gamma, and citrate synthase, was higher in tenofovir/emtricitabine-treated mice compared to other groups. Emtricitabine 173-186 citrate synthase Mus musculus 131-147 4005310-6 1985 Estimation of citrate synthase and ATP citrate lyase, in addition to the observed high activity of malate dehydrogenase, suggests a malate-citrate shuttle. malate-citrate 132-146 citrate synthase Mus musculus 14-30 35013064-7 2022 Moreover, coexpression network analysis revealed that citrate synthase, a rate-limiting enzyme in the tricarboxylic acid cycle, was localized at the center of the mitochondrial oxidation-reduction process, and its expression was significantly downreguated in Ang II-infused atria at different time points. Tricarboxylic Acids 102-120 citrate synthase Mus musculus 54-70 35000061-0 2022 Melatonin inhibits Gram-negative pathogens by targeting citrate synthase. Melatonin 0-9 citrate synthase Mus musculus 56-72 35000061-5 2022 Mechanistically, melatonin specifically inhibits the activity of citrate synthase of Gram-negative pathogens through directly binding to the R300, D363, and H265 sites, particularly for the notorious Pasteurella multocida. Melatonin 17-26 citrate synthase Mus musculus 65-81 35588524-4 2022 Elevated cardiac lactate levels were observed after high intensity running at 90% of Smax, which were parallel to increased activity of the HK and CS enzymes and mRNA levels of PGC-1alpha and COX-IV. Lactic Acid 17-24 citrate synthase Mus musculus 147-149 3800971-5 1986 The macrophages possess higher activities of citrate synthase and oxoglutarate dehydrogenase than do lymphocytes, suggesting that the tricarboxylic acid cycle may be important in energy generation in these cells. Tricarboxylic Acids 134-152 citrate synthase Mus musculus 45-61 33184414-6 2020 Remarkably, mitochondrial mass estimated by citrate synthase activity was significantly elevated in empagliflozin treated mice. empagliflozin 100-113 citrate synthase Mus musculus 44-60 6510522-2 1984 The following approximative alloxan concentrations induced 50% inhibition of enzyme activity: 10(-6)M for aconitase, 10(-4)M for NAD-linked isocitrate dehydrogenase, glutamate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinyl-CoA synthetase and fumarase, and 10(-3)M for citrate synthase and NADP-linked isocitrate dehydrogenase. Alloxan 28-35 citrate synthase Mus musculus 280-296 33994854-6 2021 BBR ameliorated mitochondrial swelling, facilitated mitochondrial fusion, and reduced mtDNA and citrate synthase activity. Berberine 0-3 citrate synthase Mus musculus 96-112 33264632-9 2021 An impact of ART on mitochondria was observed for suppression of enzymes in the citric acid cycle (TCA), such as citrate synthase (CS), isocitrate dehydrogenase (IDH2), and alpha ketoglutarate dehydrogenase (OGDH) in a dose-dependent manner. Citric Acid 80-91 citrate synthase Mus musculus 113-129 33264632-9 2021 An impact of ART on mitochondria was observed for suppression of enzymes in the citric acid cycle (TCA), such as citrate synthase (CS), isocitrate dehydrogenase (IDH2), and alpha ketoglutarate dehydrogenase (OGDH) in a dose-dependent manner. Citric Acid 80-91 citrate synthase Mus musculus 131-133 33176578-8 2021 Moreover, beta-OHB downregulated the acetyl-CoA pool and mitochondrial acetylation, partially via activation of citrate synthase and inhibition of fatty acid uptake. beta-ohb 10-18 citrate synthase Mus musculus 112-128 32855685-10 2020 RCOL administration was found to reverse EE-induced mitochondrial structural damage and alleviated defects inflicted onto the energy supply mechanism by increasing CS, SDH, Na+-K+-ATPase and glycogen levels. rcol 0-4 citrate synthase Mus musculus 164-166 31605661-8 2020 OE mice had a higher mitochondrial DNA content in both gastrocnemius than WT or KO mice and simvastatin exhibited a trend to decrease the citrate synthase activity in white and red gastrocnemius in all treatment groups. Simvastatin 92-103 citrate synthase Mus musculus 138-154 32418909-0 2020 ALA protects against ERS-mediated apoptosis in a cochlear cell model with low citrate synthase expression. Thioctic Acid 0-3 citrate synthase Mus musculus 78-94 32418909-3 2020 To investigate the pathogenesis of cochlear cell damage in A/J mice resulted from Cs mutation, we downregulated the expression level of CS in HEI-OC1, a cell line of mouse cochlea, by shRNA. Cesium 136-138 citrate synthase Mus musculus 82-84 32340625-6 2020 RESULTS: In WT, MCT treatment induced wasting of soleus and TA mass, loss of myofiber force, and depletion of citrate synthase (CS), creatine kinase (CK), and malate dehydrogenase (MDH) (all key metabolic enzymes). Monocrotaline 16-19 citrate synthase Mus musculus 110-126 32340625-6 2020 RESULTS: In WT, MCT treatment induced wasting of soleus and TA mass, loss of myofiber force, and depletion of citrate synthase (CS), creatine kinase (CK), and malate dehydrogenase (MDH) (all key metabolic enzymes). Monocrotaline 16-19 citrate synthase Mus musculus 128-130 31628154-6 2019 Genetic knockdown of citrate synthase promotes increased nuclear acetyl-CoA levels, increased histone acetylation at the FOXP3 promotor and induction of FOXP3 transcription. Acetyl Coenzyme A 65-75 citrate synthase Mus musculus 21-37 30850587-0 2019 Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis. Citric Acid 14-21 citrate synthase Mus musculus 98-100 31314583-6 2019 Maximal O2 consumption (JO2: pmol s-1 mg-1) in Dia was higher with glutamate, malate, and succinate (Dia 399 +- 127, RG 148 +- 60; P < 0.05) and palmitoyl-CoA + carnitine (Dia 15 +- 5, RG 7 +- 1; P < 0.05) than in RG, but not different between muscles when JO2 was normalized to citrate synthase activity. Oxygen 8-10 citrate synthase Mus musculus 285-301 30852322-5 2019 An interaction (TTxGTP) was observed in glucose tolerance test, total pancreas insulin concentration, and citrate synthase activity of soleus in mice. ttxgtp 16-22 citrate synthase Mus musculus 106-122 31188872-3 2019 To test this hypothesis, we applied and validated a stable isotope method to measure the ratio of pyruvate dehydrogenase flux to citrate synthase flux (VPDH/VCS, i.e. the percent of total mitochondrial oxidation fueled by glucose) in tumor cells. Glucose 222-229 citrate synthase Mus musculus 129-145 30850587-3 2019 Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes. Citric Acid 149-156 citrate synthase Mus musculus 217-233 30850587-3 2019 Here we find that hypoxia (1% O2) induces DNA damage-independent ATM activation (oxidized ATM) and suppression of oxidized ATM reduces intracellular citrate via decreasing the levels of phosphofructokinase (PFKP) and citrate synthase (CS), two key glucose metabolism-associated enzymes. Citric Acid 149-156 citrate synthase Mus musculus 235-237 30676773-2 2019 We show that insulin deficiency in streptozotocin-induced diabetic mice decreased mitochondrial ATP production and/or citrate synthase and cytochrome oxidase activities in the cerebrum, hypothalamus, and hippocampus. Streptozocin 35-49 citrate synthase Mus musculus 118-134 30944739-2 2019 The aim of this study was to test the hypothesis that low CS activity impairs the metabolic health of mice fed a high fat diet (HFD) and promotes palmitate-induced lipotoxicity in muscle cells. Palmitates 146-155 citrate synthase Mus musculus 58-60 29210997-6 2017 Chronic tempol supplementation in the drinking water increased diaphragm functional capacity and citrate synthase and lactate dehydrogenase enzymatic activities, restoring all values to wild-type levels. Water 47-52 citrate synthase Mus musculus 97-113 30031043-10 2018 Protein expression of PGC-1alpha, citrate synthase activity and mtDNA copy number were all decreased in livers of sunitinib-treated mice, indicating impaired mitochondrial proliferation. Sunitinib 114-123 citrate synthase Mus musculus 34-50 28947262-8 2017 Furthermore, liver pyruvate, as well as mRNA levels of enzymes involved in the Krebs cycle, such as citrate synthase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase, increased in the PFOA-treated group. krebs 79-84 citrate synthase Mus musculus 100-116 28947262-8 2017 Furthermore, liver pyruvate, as well as mRNA levels of enzymes involved in the Krebs cycle, such as citrate synthase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase, increased in the PFOA-treated group. perfluorooctanoic acid 200-204 citrate synthase Mus musculus 100-116 28712868-8 2017 Importantly, salicylate treatment significantly increased the number of mDNA, citrate synthase activity, expression of respiratory chain complex I, and mitochondrial mass, which were suppressed by the specific AMPK inhibitor Compound C. Indeed, salicylate treatment induced the phosphorylation of AMPK, which was involved in the induction of PGC-1alpha, NRF1, and TFAM. Salicylates 13-23 citrate synthase Mus musculus 78-94 28712868-8 2017 Importantly, salicylate treatment significantly increased the number of mDNA, citrate synthase activity, expression of respiratory chain complex I, and mitochondrial mass, which were suppressed by the specific AMPK inhibitor Compound C. Indeed, salicylate treatment induced the phosphorylation of AMPK, which was involved in the induction of PGC-1alpha, NRF1, and TFAM. Salicylates 245-255 citrate synthase Mus musculus 78-94 28115273-7 2017 Our results revealed compromised echocardiographic, contractile and intracellular Ca2+ handling properties along with overt mitochondrial damage (reduced levels of PGC-1alpha, aconitase, citrate synthase activity and NAD+) in mice challenged with paraquat (45mg/kg, single injection, i.p. Paraquat 247-255 citrate synthase Mus musculus 187-203 28641785-6 2017 At the metabolic level, there was a nonsignificant (p=0.076) ~40% decrease in glucose contribution to pyruvate and lactate formation through glycolysis and to mitochondrial citrate synthase flux (6.6+-1.1 vs. 11.2+-2.2%), and an 35% increase in tissue pyruvate (27+-2 vs. 20+-2pmol/mg; p=0.033). Glucose 78-85 citrate synthase Mus musculus 173-189 28216161-0 2017 Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis. Superoxides 58-68 citrate synthase Mus musculus 22-38 28216161-3 2017 To understand the effects of a decreased CS activity that results from the mutation in Cs gene on hearing loss in A/J mice, human kidney cell line (293T) was transiently transfected with short hairpin RNA for Cs (shRNA-Cs) to reduce expression of CS. Cesium 87-89 citrate synthase Mus musculus 41-43 28232454-11 2017 Mitochondrial oxygen flux rates of FF mice diet were uniformly lower with all the tested substrates (13-276 pmol s-1 ml-1 per unit citrate synthase) than SC mice (17-394 pmol s-1 ml-1 per unit citrate synthase) and was accompanied by decreased mitochondrial:nuclear gene copy number ratios after 4 wk. Oxygen 14-20 citrate synthase Mus musculus 131-147 26553608-4 2016 Here, we analyzed for first time the changes in the maximal activity of key enzymes related to fatty acid (Carnitine palmitoyltransferase and beta-Hydroxyacyl CoA dehydrogenase) and carbohydrate (Pyruvate kinase, Phosphofructokinase and Lactate dehydrogenase) catabolism, as well as mitochondrial oxidative capacity (Citrate synthase), in six organs of torpid, arousing and euthermic Chilean mouse-opossums (Thylamys elegans). Fatty Acids 95-105 citrate synthase Mus musculus 317-333 28061324-8 2017 In addition, there were striking increases in both citrate synthase gene expression and enzymatic activity in skeletal muscle of mice in the corticosterone group relative to vehicle control. Corticosterone 141-155 citrate synthase Mus musculus 51-67 27836895-12 2017 Quercetin evoked higher protein abundance of PGC-1alpha, cytochrome c, ETC complexes I-V, citrate synthase, SOD2, and GPX compared with control-fed Mdx/Utrn+/- Quercetin decreased abundance of inflammatory markers including NFkappaB, TGF-beta1, and F4/80 compared with Mdx/Utrn+/-; however, P-NFkappaB, P-IKBalpha, IKBalpha, CD64, and COX2 were similar between groups. Quercetin 0-9 citrate synthase Mus musculus 90-106 27594836-13 2016 Both NMN and exercise ameliorated the HFD-induced reduction in liver citrate synthase activity. Nicotinamide Mononucleotide 5-8 citrate synthase Mus musculus 69-85 28223344-6 2017 Ceramides substantially attenuated mitochondrial citrate synthase activities primarily through the induction of endoplasmic reticulum stress, which triggers increased hepatic mitochondrial acetyl-CoA levels and PC activities. Ceramides 0-9 citrate synthase Mus musculus 49-65 27245589-8 2016 Moreover, BCAAem maintained mitochondrial mass and density and citrate synthase activity in skeletal muscle of Rvs-treated mice beside oxygen consumption and ATP levels in C2C12 cells exposed to statin. bcaaem 10-16 citrate synthase Mus musculus 63-79 27245589-8 2016 Moreover, BCAAem maintained mitochondrial mass and density and citrate synthase activity in skeletal muscle of Rvs-treated mice beside oxygen consumption and ATP levels in C2C12 cells exposed to statin. Rosuvastatin Calcium 111-114 citrate synthase Mus musculus 63-79 26553608-4 2016 Here, we analyzed for first time the changes in the maximal activity of key enzymes related to fatty acid (Carnitine palmitoyltransferase and beta-Hydroxyacyl CoA dehydrogenase) and carbohydrate (Pyruvate kinase, Phosphofructokinase and Lactate dehydrogenase) catabolism, as well as mitochondrial oxidative capacity (Citrate synthase), in six organs of torpid, arousing and euthermic Chilean mouse-opossums (Thylamys elegans). Carbohydrates 182-194 citrate synthase Mus musculus 317-333 25998543-4 2015 A moderate reduction of citrate synthase and isocitrate dehydrogenase activities was observed only in the striatum from 30-day-old Gcdh-/- animals submitted to a high Lys chow. Lysine 167-170 citrate synthase Mus musculus 24-40 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Tyrosine 0-8 citrate synthase Mus musculus 169-185 25835781-6 2015 When we studied the Krebs cycle functionality through the measurement of the specific citrate synthase activity, we found it to be significantly diminished during the acute phase of the infection in Tulahuen and SGO Z12 infected groups with respect to the control one; citrate synthase activity from the Lucky group was significantly increased (p<0.05). krebs 20-25 citrate synthase Mus musculus 86-102 25835781-6 2015 When we studied the Krebs cycle functionality through the measurement of the specific citrate synthase activity, we found it to be significantly diminished during the acute phase of the infection in Tulahuen and SGO Z12 infected groups with respect to the control one; citrate synthase activity from the Lucky group was significantly increased (p<0.05). krebs 20-25 citrate synthase Mus musculus 269-285 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Tyrosine 0-8 citrate synthase Mus musculus 187-189 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Arginine 10-18 citrate synthase Mus musculus 169-185 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Arginine 10-18 citrate synthase Mus musculus 187-189 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Homoarginine 22-34 citrate synthase Mus musculus 169-185 25333616-6 2014 Tyrosine, arginine or homoarginine treatment in particular showed anti-apoptotic effects; increased alpha-ketoglutarate dehydrogenase complex (OGDC), fumarase (FH), and citrate synthase (CS) expression; and relieved the observed impairment in energy metabolism. Homoarginine 22-34 citrate synthase Mus musculus 187-189 24964389-8 2014 ADP-dependent mitochondrial respiration, complex I and III activities, and citrate synthase activity were significantly decreased in the SKM of the HFD+vehicle animals, and these decreases were also attenuated by pioglitazone. Pioglitazone 213-225 citrate synthase Mus musculus 75-91 25142190-9 2014 CONCLUSION: We suggest that the inhibition of complex I in the hippocampus only and activation of complex IV, citrate synthase and creatine kinase occurs because of a stimulus effect of mazindol in the central nervous system, which causes a direct impairment on energy metabolism. Mazindol 186-194 citrate synthase Mus musculus 110-126