PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 25130677-6 2014 Compared with the ACA patients, the SCC patients were younger and more frequently black and had a higher degree of illiteracy and alcohol and tobacco consumers. Alcohols 130-137 serpin family B member 3 Homo sapiens 36-39 25295539-4 2014 Chronic application of 1-fluoro-2,4-dinitrobenzene (DNFB) to carcinogen-treated skin led to the development of papillomas and aggressive SCC. Dinitrofluorobenzene 23-50 serpin family B member 3 Homo sapiens 137-140 25295539-4 2014 Chronic application of 1-fluoro-2,4-dinitrobenzene (DNFB) to carcinogen-treated skin led to the development of papillomas and aggressive SCC. Dinitrofluorobenzene 52-56 serpin family B member 3 Homo sapiens 137-140 25360224-9 2014 The relative expression of mir-375 in laryngeal SCC was shown to be associated with localization of the tumor in these patients (p = 0.037) and with alcohol use (p < 0.05). Alcohols 149-156 serpin family B member 3 Homo sapiens 48-51 25538369-3 2014 MATERIALS AND METHODS: This study was carried out on 123 paraffin embedded blocks with exact diagnosis of squamous cell carcinoma (SCC). Paraffin 57-65 serpin family B member 3 Homo sapiens 131-134 25155911-4 2014 CONCLUSIONS: Development of SCC is a previously unreported adverse reaction to nilotinib. nilotinib 79-88 serpin family B member 3 Homo sapiens 28-31 25328552-2 2014 While exposures to main risk factors for oral SCC such as smoking and alcohol use are higher amongst the Aboriginal people, little is known about oral cancer in this population. Alcohols 70-77 serpin family B member 3 Homo sapiens 46-49 24609521-9 2014 The combined HR (95 % CI) of OS was 2.29 (1.26, 4.17) for ADs and 3.21 (1.69, 6.09) for SCC. Osmium 29-31 serpin family B member 3 Homo sapiens 88-91 25408647-2 2014 In this report, we describe two cases of SCC on the ear successfully treated with intra-arterial administration of peplomycin through a superficial temporal artery. Peplomycin 115-125 serpin family B member 3 Homo sapiens 41-44 25408647-4 2014 These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear. Peplomycin 61-71 serpin family B member 3 Homo sapiens 138-141 25408647-4 2014 These findings suggest that intra-arterial administration of peplomycin with tegafur is one of the optimal therapies for the treatment of SCC developing on the ear. Tegafur 77-84 serpin family B member 3 Homo sapiens 138-141 25210795-7 2014 In line, suppression of Mcl-1 by the pan-Bcl-2 inhibitor Obatoclax or overexpression of Noxa rendered resistant SCC cells sensitive to BH3 mimetics. BH 3 135-138 serpin family B member 3 Homo sapiens 112-115 25210795-9 2014 Therefore, combination treatment of ABT737 or derivatives with Mcl-1 inhibitors, or inducers of Noxa, may represent a novel option of targeted therapy in metastatic SCC of the skin. ABT-737 36-42 serpin family B member 3 Homo sapiens 165-168 25143750-9 2014 CONCLUSION: The results of this study and previous in vitro studies suggest a potential role for CPA in the treatment of AK lesions and the prevention of SCC development. cpa 97-100 serpin family B member 3 Homo sapiens 154-157 25133778-2 2014 Accordingly, the recent duplicates SERPINB3 and B4 located in human 18q21.3 SERPIN cluster control the activity of different cysteine and serine proteases, respectively. Cysteine 125-133 serpin family B member 3 Homo sapiens 35-43 25564056-3 2014 The expression of Ki-67 in the biopsy specimens of cervical SCC was detected by immunohistochemistry at diagnosis and after 10 Gy radiotherapy. ki-67 18-23 serpin family B member 3 Homo sapiens 60-63 24917395-0 2014 Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. Prostaglandins 106-119 serpin family B member 3 Homo sapiens 74-77 24917395-0 2014 Aldo-keto reductase 1C3 is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism. Prostaglandins 106-119 serpin family B member 3 Homo sapiens 91-94 24917395-6 2014 AKR1C3 was detected in all SCC cell lines and its expression was upregulated in response to its substrate, PGD2 . Prostaglandin D2 107-111 serpin family B member 3 Homo sapiens 27-30 24917395-7 2014 Although attenuating AKR1C3 expression in SCC cells by siRNA did not affect growth, treatment with PGD2 and its dehydration metabolite, 15d-PGJ2 , decreased SCC proliferation in a PPARgamma-dependent manner. Prostaglandin D2 99-103 serpin family B member 3 Homo sapiens 157-160 24917395-7 2014 Although attenuating AKR1C3 expression in SCC cells by siRNA did not affect growth, treatment with PGD2 and its dehydration metabolite, 15d-PGJ2 , decreased SCC proliferation in a PPARgamma-dependent manner. 15-deoxy-delta(12,14)-prostaglandin J2 136-144 serpin family B member 3 Homo sapiens 157-160 24917395-8 2014 In addition, treatment with the PPARgamma agonist pioglitazone profoundly inhibited SCC proliferation. Pioglitazone 50-62 serpin family B member 3 Homo sapiens 84-87 24917395-10 2014 SCC-AKR1C3 metabolized PGD2 to 9alpha11beta-PGF2 12-fold faster than the parent cell line and was protected from the antiproliferative effect mediated by PGD2 . Prostaglandin D2 23-27 serpin family B member 3 Homo sapiens 0-3 24917395-10 2014 SCC-AKR1C3 metabolized PGD2 to 9alpha11beta-PGF2 12-fold faster than the parent cell line and was protected from the antiproliferative effect mediated by PGD2 . Dinoprost 31-48 serpin family B member 3 Homo sapiens 0-3 24917395-10 2014 SCC-AKR1C3 metabolized PGD2 to 9alpha11beta-PGF2 12-fold faster than the parent cell line and was protected from the antiproliferative effect mediated by PGD2 . Prostaglandin D2 154-158 serpin family B member 3 Homo sapiens 0-3 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Prostaglandin D2 24-28 serpin family B member 3 Homo sapiens 67-70 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Prostaglandin D2 24-28 serpin family B member 3 Homo sapiens 219-222 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. 15-deoxy-delta(12,14)-prostaglandin J2 48-56 serpin family B member 3 Homo sapiens 67-70 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. 15-deoxy-delta(12,14)-prostaglandin J2 48-56 serpin family B member 3 Homo sapiens 219-222 24918866-9 2014 For the long-term outcome of NACT, patients with SCC experienced a significant 5-year overall survival (OS) and progress-free survival (PFS) when compared to patients with non-SCC in pooled [1.47 (95%CI 1.06-2.06)] and observational studies [1.96 (95%CI 1.61-2.38)] other than RCTs (P>0.05). nact 29-33 serpin family B member 3 Homo sapiens 49-52 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Pioglitazone 172-184 serpin family B member 3 Homo sapiens 67-70 24917395-11 2014 This work suggests that PGD2 and its metabolite 15d-PGJ2 attenuate SCC proliferation in a PPARgamma-dependent manner, therefore activation of PPARgamma by agonists such as pioglitazone may benefit those at high risk of SCC. Pioglitazone 172-184 serpin family B member 3 Homo sapiens 219-222 24509533-0 2014 The oncogene ATF3 is potentiated by cyclosporine A and ultraviolet light A. Cutaneous squamous cell carcinoma (SCC) represents the most important cutaneous complication following organ transplantation. Cyclosporine 36-50 serpin family B member 3 Homo sapiens 111-114 24988190-9 2014 In conclusion, transcutaneous CO2 suppressed tumor growth, increased mitochondrial apoptosis and decreased the number of lymph node metastasis in human SCC by decreasing intra-tumoral hypoxia and suppressing metastatic potential with no observable effect in vivo. Carbon Dioxide 30-33 serpin family B member 3 Homo sapiens 152-155 24988190-10 2014 Our findings indicate that transcutaneous CO2 could be a novel therapeutic tool for treating human SCC. Carbon Dioxide 42-45 serpin family B member 3 Homo sapiens 99-102 24641301-3 2014 Treatment with vemurafenib, and to a lesser extent, sorafenib, a relatively non-specific inhibitor of BRAF, has been associated with cutaneous squamous cell carcinoma (SCC). Vemurafenib 15-26 serpin family B member 3 Homo sapiens 168-171 24641301-3 2014 Treatment with vemurafenib, and to a lesser extent, sorafenib, a relatively non-specific inhibitor of BRAF, has been associated with cutaneous squamous cell carcinoma (SCC). Sorafenib 52-61 serpin family B member 3 Homo sapiens 168-171 24810714-3 2014 We report that SB3 shields cells from the toxicity of drugs with a pro-oxidant action such as doxorubicin, cisplatin and EM20-25. Doxorubicin 94-105 serpin family B member 3 Homo sapiens 15-18 24503858-0 2014 Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma. Aldosterone 112-123 serpin family B member 3 Homo sapiens 27-36 24503858-5 2014 The proteomic analysis showed a different expression of Serpin B3 Inhibitor-SCCA1 (SB3) in APA and BAH patients. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate 99-102 serpin family B member 3 Homo sapiens 56-65 24810714-3 2014 We report that SB3 shields cells from the toxicity of drugs with a pro-oxidant action such as doxorubicin, cisplatin and EM20-25. Cisplatin 107-116 serpin family B member 3 Homo sapiens 15-18 24810714-6 2014 Mitochondrial SB3 inhibits ROS generation and the ensuing PTP induction and cell death through an inhibitory interaction with respiratory Complex I. ros 27-30 serpin family B member 3 Homo sapiens 14-17 24108656-8 2014 SCC grading correlated significantly with recurrence rate (P = 0.005), DFS (P = 0.004), and DSS (P = 0.0036). dss 92-95 serpin family B member 3 Homo sapiens 0-3 24684417-4 2014 OBJECTIVE: To describe benign histologic mimickers of PNI and neural structures in SCC commonly encountered on frozen, hematoxylin and eosin-stained sections and to review how to differentiate them from PNI. Hematoxylin 119-130 serpin family B member 3 Homo sapiens 83-86 24684417-4 2014 OBJECTIVE: To describe benign histologic mimickers of PNI and neural structures in SCC commonly encountered on frozen, hematoxylin and eosin-stained sections and to review how to differentiate them from PNI. Eosine Yellowish-(YS) 135-140 serpin family B member 3 Homo sapiens 83-86 24560559-3 2014 RESULTS: Stromal alpha-SMA positivity was observed in 100% (20 of 20) of the SCC and in 93% (14 of 15) of the VC, whereas none of the VH (0 of 13) or adjacent uninvolved stroma (0 of 16) demonstrated alpha-SMA reactivity. alpha-sma 17-26 serpin family B member 3 Homo sapiens 77-80 24218024-7 2014 In contrast, p16-negative SCC generally showed diffuse and concordant cyclin D1 and Ki67 labelling, including at the invasive margin. ki67 84-88 serpin family B member 3 Homo sapiens 26-29 24535589-6 2014 Commonly, the emergence of the SCC occurs in patients with high-grade adenocarcinoma who are often treated with androgen deprivation treatment (ADT). adt 144-147 serpin family B member 3 Homo sapiens 31-34 24774218-10 2014 And, in cervical SCC patients after treatment with Taxol chemotherapy, the expression level of miR-143 was higher and the positive expression of bcl-2 protein was lower. Paclitaxel 51-56 serpin family B member 3 Homo sapiens 17-20 25009037-7 2014 Results from interaction analysis showed that serum folate deficiency had an additive interaction with HPV16 infection in CIN II/III and SCC, while RBC folate having an additive interaction with HPV16 infection in the whole process of cervix cancerization. Folic Acid 52-58 serpin family B member 3 Homo sapiens 137-140 24480403-7 2014 MMT provided a significant survival-advantage over surgical monotherapy for AC (P=0.004), SCC (P=0.01). 2-methylcyclopentadienyl manganese tricarbonyl 0-3 serpin family B member 3 Homo sapiens 90-93 24480403-9 2014 MMT produced a pathologic complete response (pCR) in 25% and 31% of AC and SCC, respectively. 2-methylcyclopentadienyl manganese tricarbonyl 0-3 serpin family B member 3 Homo sapiens 75-78 24480403-10 2014 Survival advantage accrued to MMT, pCR and node-negative patients: AC pCR versus surgical monotherapy (P=0.001); residual disease following MMT versus surgical monotherapy (P=0.008); SCC pCR versus surgical monotherapy (P=0.033). 2-methylcyclopentadienyl manganese tricarbonyl 30-33 serpin family B member 3 Homo sapiens 183-186 24327272-5 2014 RESULTS: Cetuximab and namitecan exhibited synergistic effects, resulting in potentiation of cell growth inhibition and, most importantly, enhanced therapeutic efficacy, with high cure rates in three SCC models characterized by high EGFR gene copy number, without increasing toxicity. namitecan 23-32 serpin family B member 3 Homo sapiens 200-203 24614132-8 2014 CONCLUSION: AC and SCC showed different patterns in both tumor vascularity and glucose metabolism. Glucose 79-86 serpin family B member 3 Homo sapiens 19-22 24081649-9 2014 CONCLUSIONS: DECT-derived iodine content and overlay differ significantly among normal, inflammatory and metastatic SCC cervical lymph nodes. Iodine 26-32 serpin family B member 3 Homo sapiens 116-119 24327272-9 2014 CONCLUSIONS: Our results (i) demonstrate a marked efficacy of the cetuximab-namitecan combination, which reflects a complete abrogation of EGFR expression as a critical determinant of the therapeutic improvement, in SCC preclinical models, and (ii) suggest EGFR gene copy number as a possible marker to be used for patient selection in the clinical setting. cetuximab-namitecan 66-85 serpin family B member 3 Homo sapiens 216-219 24524628-11 2014 Selective ablation of IB4(+) neurons by IB4-SAP decreased mechanical allodynia in mice with SCC. ib4 22-25 serpin family B member 3 Homo sapiens 92-95 24574421-8 2014 CONCLUSIONS: Adjuvant irradiation after TLM resection of oropharyngeal SCC with intermediate- or high-risk features improves locoregional control compared with TLM alone. thiolactomycin 40-43 serpin family B member 3 Homo sapiens 71-74 24302676-3 2014 Insertion of CO2 into the newly formed Sc-C bond leads to a kappa(1) carboxylate which, when treated with the borane B(C6F5)3, becomes hemilabile. Carbon Dioxide 13-16 serpin family B member 3 Homo sapiens 39-43 24302676-3 2014 Insertion of CO2 into the newly formed Sc-C bond leads to a kappa(1) carboxylate which, when treated with the borane B(C6F5)3, becomes hemilabile. (1) carboxylate 65-80 serpin family B member 3 Homo sapiens 39-43 24302676-3 2014 Insertion of CO2 into the newly formed Sc-C bond leads to a kappa(1) carboxylate which, when treated with the borane B(C6F5)3, becomes hemilabile. borane b(c6f5)3 110-125 serpin family B member 3 Homo sapiens 39-43 24448358-10 2014 Expression of miR-128, -10b, -502-3p and -192 differed between SCC and AC, and miR-128 and -192 - between NLP and NSCLC. mir-128 14-21 serpin family B member 3 Homo sapiens 63-66 25050333-2 2014 METHODS: Between May 2010 and April 2012, 30 patients with head and neck SCC underwent preoperative DWI and CTP. Cytidine Triphosphate 108-111 serpin family B member 3 Homo sapiens 73-76 25422218-7 2014 Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1). Folic Acid 132-138 serpin family B member 3 Homo sapiens 179-182 25422218-7 2014 Interaction analysis showed that the ORs only with FHIT methylation (OR=11.47) or only with HPV 16 positive (OR=4.63) or with serum folate level lower than 3.19ng/ml (OR=1.68) in SCC group were all higher than the control status of HPV 16 negative and FHIT unmethylation and serum folate level more than 3.19ng/ml (OR=1). Folic Acid 281-287 serpin family B member 3 Homo sapiens 179-182 23872349-1 2013 BACKGROUND: Chronic high arsenic exposure is associated with squamous cell carcinoma (SCC) of the skin, and inorganic arsenic (iAs) metabolites may play an important role in this association. Arsenic 25-32 serpin family B member 3 Homo sapiens 86-89 23623598-9 2014 Meanwhile, plasma CEA, NSE and SCC were negatively correlated with serum folate. Folic Acid 73-79 serpin family B member 3 Homo sapiens 31-34 24046296-1 2013 BACKGROUND: Voriconazole long-term therapy is suspected to induce cutaneous squamous cell carcinoma (SCC), as suggested by 18 case reports worldwide and 3 retrospective studies. Voriconazole 12-24 serpin family B member 3 Homo sapiens 101-104 24046296-7 2013 Cumulative mean duration of voriconazole therapy at SCC diagnosis was 35 months (range, 7-63 months). Voriconazole 28-40 serpin family B member 3 Homo sapiens 52-55 24046296-10 2013 CONCLUSIONS: Our results suggest that long-term voriconazole prescription may be associated with a multistep phototoxic process involving acute skin lesions followed by AK then by SCC. Voriconazole 48-60 serpin family B member 3 Homo sapiens 180-183 24389432-1 2013 INTRODUCTION: In a previous biomarker discovery project using gene-expression profiling we identified Serpin B3 (SB3) as a predictor of resistance to platinum doublet chemotherapy (PtC) in non-small-cell lung cancer (NSCLC). Platinum 150-158 serpin family B member 3 Homo sapiens 102-111 24389432-1 2013 INTRODUCTION: In a previous biomarker discovery project using gene-expression profiling we identified Serpin B3 (SB3) as a predictor of resistance to platinum doublet chemotherapy (PtC) in non-small-cell lung cancer (NSCLC). Platinum 150-158 serpin family B member 3 Homo sapiens 113-116 24389432-9 2013 CONCLUSIONS: SB3-positive immunohistochemistry score of 2 or more (>10% tumor cells positive) identifies a subgroup of patients with stage IV NSCLC who have a poor survival (median 120 days) when treated with PtC, similar to that estimated for untreated or chemo-refractory stage IV NSCLC. Peptichemio 212-215 serpin family B member 3 Homo sapiens 13-16 24037775-1 2013 BACKGROUND: Weekly or daily cisplatin and 5-fluorouracil (5-FU)-based chemoradiation was evaluated for patients with locally advanced squamous cell carcinoma (SCC) of the anal canal treated at a single institution over a 20-year period. Fluorouracil 42-56 serpin family B member 3 Homo sapiens 159-162 24037775-1 2013 BACKGROUND: Weekly or daily cisplatin and 5-fluorouracil (5-FU)-based chemoradiation was evaluated for patients with locally advanced squamous cell carcinoma (SCC) of the anal canal treated at a single institution over a 20-year period. Fluorouracil 58-62 serpin family B member 3 Homo sapiens 159-162 24037775-2 2013 METHODS: A retrospective, single-institution analysis was conducted of patients receiving concurrent 5-FU/cisplatin and radiotherapy for locally advanced SCC from 1989 to 2009. Fluorouracil 101-105 serpin family B member 3 Homo sapiens 154-157 24037775-14 2013 CONCLUSIONS: The combination of weekly/daily cisplatin and 5-FU-based chemotherapy with concurrent radiotherapy is an effective regimen, and our long-term results indicate that cisplatin is an alternative to mitomycin C and may be considered for the treatment of locally advanced SCC of the anal canal. Cisplatin 45-54 serpin family B member 3 Homo sapiens 280-283 24037775-14 2013 CONCLUSIONS: The combination of weekly/daily cisplatin and 5-FU-based chemotherapy with concurrent radiotherapy is an effective regimen, and our long-term results indicate that cisplatin is an alternative to mitomycin C and may be considered for the treatment of locally advanced SCC of the anal canal. Fluorouracil 59-63 serpin family B member 3 Homo sapiens 280-283 24037775-14 2013 CONCLUSIONS: The combination of weekly/daily cisplatin and 5-FU-based chemotherapy with concurrent radiotherapy is an effective regimen, and our long-term results indicate that cisplatin is an alternative to mitomycin C and may be considered for the treatment of locally advanced SCC of the anal canal. Cisplatin 177-186 serpin family B member 3 Homo sapiens 280-283 23872349-3 2013 OBJECTIVE: We estimated associations between total urinary arsenic and arsenic species and SCC in a U.S. population. Arsenic 59-66 serpin family B member 3 Homo sapiens 91-94 23872349-3 2013 OBJECTIVE: We estimated associations between total urinary arsenic and arsenic species and SCC in a U.S. population. Arsenic 71-78 serpin family B member 3 Homo sapiens 91-94 23872349-8 2013 Urinary ln(MMA) and ln(DMA) also were positively associated with SCC (OR = 1.34; 95% CI: 1.04, 1.71 and OR = 1.34; 95% CI: 1.03, 1.74, respectively). monomethylarsonic acid 11-14 serpin family B member 3 Homo sapiens 65-68 23872349-8 2013 Urinary ln(MMA) and ln(DMA) also were positively associated with SCC (OR = 1.34; 95% CI: 1.04, 1.71 and OR = 1.34; 95% CI: 1.03, 1.74, respectively). Cacodylic Acid 23-26 serpin family B member 3 Homo sapiens 65-68 23872349-11 2013 CONCLUSIONS: These results suggest that arsenic exposure at levels common in the United States relates to SCC and that arsenic metabolism ability does not modify the association. Arsenic 40-47 serpin family B member 3 Homo sapiens 106-109 23302597-11 2014 In addition, our results suggested that nitric oxide metabolism plays a key role in the regulation of SVR, both in SCA and SCC. Nitric Oxide 40-52 serpin family B member 3 Homo sapiens 123-126 23824258-2 2014 The purpose of this study was to investigate the association between caffeine intake and incidence of basal cell (BCC) and squamous cell carcinoma (SCC). Caffeine 69-77 serpin family B member 3 Homo sapiens 148-151 24958990-5 2014 Here, we presented a case of GI mimicking SCC of penis, which was diagnosed on basis of histopathology and treated with excision followed by medical therapy with cotrimoxazole. Trimethoprim, Sulfamethoxazole Drug Combination 162-175 serpin family B member 3 Homo sapiens 42-45 23216663-9 2014 Patients with SCC had a higher cumulative dose of azathioprine (>= 500 g: OR 30.0 [95% CI 2.6-345.1]) and longer treatment duration (>= 11 years: OR 13.5 [95% CI 1.3-143.6]). Azathioprine 50-62 serpin family B member 3 Homo sapiens 14-17 23216663-11 2014 CONCLUSIONS: In this cohort of patients with AIRD treated with azathioprine for at least 1 year, the risk of SCC was increased, as compared with the general population. Azathioprine 63-75 serpin family B member 3 Homo sapiens 109-112 23668929-2 2013 This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. gemcitabine 88-99 serpin family B member 3 Homo sapiens 147-150 23668929-2 2013 This study aimed to evaluate the therapeutic effects of intraarterial chemotherapy with gemcitabine and cisplatin on locally advanced or recurrent SCC of the penis. Cisplatin 104-113 serpin family B member 3 Homo sapiens 147-150 23668929-10 2013 Intraarterial chemotherapy with gemcitabine and cisplatin may be effective and potentially curative in locoregionally advanced or recurrent penile SCC. gemcitabine 32-43 serpin family B member 3 Homo sapiens 147-150 23668929-10 2013 Intraarterial chemotherapy with gemcitabine and cisplatin may be effective and potentially curative in locoregionally advanced or recurrent penile SCC. Cisplatin 48-57 serpin family B member 3 Homo sapiens 147-150 24037930-3 2013 Oral retinoids have been proven to be effective in the suppression of new squamous cell carcinoma (SCC) development. Retinoids 5-14 serpin family B member 3 Homo sapiens 99-102 24037930-7 2013 Field therapy for areas of severe actinic damage with photodynamic therapy, imiquimod, 5-fluorouracil, ingenol mebutate, or diclofenac sodium may theoretically decrease the risk of SCC through treatment of precancerous changes. Fluorouracil 87-101 serpin family B member 3 Homo sapiens 181-184 24037930-7 2013 Field therapy for areas of severe actinic damage with photodynamic therapy, imiquimod, 5-fluorouracil, ingenol mebutate, or diclofenac sodium may theoretically decrease the risk of SCC through treatment of precancerous changes. 3-ingenyl angelate 103-119 serpin family B member 3 Homo sapiens 181-184 24037930-7 2013 Field therapy for areas of severe actinic damage with photodynamic therapy, imiquimod, 5-fluorouracil, ingenol mebutate, or diclofenac sodium may theoretically decrease the risk of SCC through treatment of precancerous changes. Diclofenac 124-141 serpin family B member 3 Homo sapiens 181-184 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 142-154 serpin family B member 3 Homo sapiens 135-138 22544338-7 2013 Five-year disease-specific survival (DSS) rates were 57.5 % in UC and 39.1 % in SCC group (p = 0.011). dss 37-40 serpin family B member 3 Homo sapiens 80-83 22544338-8 2013 Five-year DSS rates were 81.2 % in UC and 75.0 % in SCC group in organ-confined disease (p = 0.534) and 28.2 % in UC and 40.9 % in SCC group in extravesical disease (p = 0.845). dss 10-13 serpin family B member 3 Homo sapiens 52-55 22544338-9 2013 In lymph node-positive patients, DSS time was 20.9 +- 2.85 months in UC and 12.8 +- 2.07 months in SCC patients (p = 0.182). dss 33-36 serpin family B member 3 Homo sapiens 99-102 24098753-2 2013 In the present study, an MTT assay demonstrated that isoalantolactone has anti-proliferative activity against the HNSCC cell line (UM-SCC-10A). isoalantolactone 53-69 serpin family B member 3 Homo sapiens 116-119 24098753-6 2013 Together, our findings suggest that isoalantolactone induced caspase-dependent apoptosis via a mitochondrial pathway and was associated with cell cycle arrest in the G1 phase in UM-SCC-10A cells. isoalantolactone 36-52 serpin family B member 3 Homo sapiens 181-184 23797868-3 2013 METHODS: Disease-specific survival (DSS) was assessed among SCC patients with cervical lymph node metastases (n = 347, including 133 patients with OPC and 214 patients with OCC). dss 36-39 serpin family B member 3 Homo sapiens 60-63 24098753-0 2013 Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction. isoalantolactone 0-16 serpin family B member 3 Homo sapiens 29-32 24044722-1 2013 BACKGROUND: Squamous cell carcinoma (SCC) as the malignant component of carcinoma ex pleomorphic adenoma (CXPA) occurring in upper lip is rare. cxpa 106-110 serpin family B member 3 Homo sapiens 37-40 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 156-159 serpin family B member 3 Homo sapiens 135-138 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 156-159 serpin family B member 3 Homo sapiens 182-185 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 189-192 serpin family B member 3 Homo sapiens 135-138 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 189-192 serpin family B member 3 Homo sapiens 182-185 24008736-3 2013 MTX increased WWOX expression, accompanied by caspase activation and apoptosis, in MTX-sensitive SCC cell lines and tumor biopsies. Methotrexate 0-3 serpin family B member 3 Homo sapiens 97-100 24008736-3 2013 MTX increased WWOX expression, accompanied by caspase activation and apoptosis, in MTX-sensitive SCC cell lines and tumor biopsies. Methotrexate 83-86 serpin family B member 3 Homo sapiens 97-100 24008736-4 2013 Suppression by a dominant-negative or small interfering RNA targeting WWOX blocked MTX-mediated cell death in sensitive SCC-15 cells that highly expressed WWOX. Methotrexate 83-86 serpin family B member 3 Homo sapiens 120-123 24008736-5 2013 In stark contrast, SCC-9 cells expressed minimum amount of WWOX protein and resisted MTX-induced apoptosis. Methotrexate 85-88 serpin family B member 3 Homo sapiens 19-22 24008736-2 2013 We show here that tumor suppressor WW domain-containing oxidoreductase (WWOX) (also named FOR or WOX1) regulates the susceptibility of SCC to methotrexate (MTX) in vitro and cure of SCC in MTX therapy. Methotrexate 142-154 serpin family B member 3 Homo sapiens 182-185 24008736-6 2013 Transiently overexpressed WWOX sensitized SCC-9 cells to apoptosis by MTX. Methotrexate 70-73 serpin family B member 3 Homo sapiens 42-45 24008736-7 2013 MTX significantly downregulated autophagy-related Beclin-1, Atg12-Atg5 and LC3-II protein expression and autophagosome formation in the sensitive SCC-15, whereas autophagy remained robust in the resistant SCC-9. Methotrexate 0-3 serpin family B member 3 Homo sapiens 146-149 23045958-1 2013 BACKGROUND: The aim of this study was to evaluate whether Fas (CD95) and Fas ligand (FasL) immunoreactivity in cutaneous squamous cell carcinoma (SCC) are correlated with grade of tumor differentiation. ammonium ferrous sulfate 58-61 serpin family B member 3 Homo sapiens 146-149 24008736-7 2013 MTX significantly downregulated autophagy-related Beclin-1, Atg12-Atg5 and LC3-II protein expression and autophagosome formation in the sensitive SCC-15, whereas autophagy remained robust in the resistant SCC-9. Methotrexate 0-3 serpin family B member 3 Homo sapiens 205-208 24008736-8 2013 Mechanistically, WWOX physically interacted with mammalian target of rapamycin (mTOR), which potentiated MTX-increased phosphorylation of mTOR and its downstream substrate p70 S6 kinase, along with dramatic downregulation of the aforementioned proteins in autophagy, in SCC-15. Methotrexate 105-108 serpin family B member 3 Homo sapiens 270-273 24008736-9 2013 When WWOX was knocked down in SCC-15, MTX-induced mTOR signaling and autophagy inhibition were blocked. Methotrexate 38-41 serpin family B member 3 Homo sapiens 30-33 24008736-10 2013 Thus, WWOX renders SCC cells susceptible to MTX-induced apoptosis by dampening autophagy, and the failure in inducing WWOX expression leads to chemotherapeutic drug resistance. Methotrexate 44-47 serpin family B member 3 Homo sapiens 19-22 22907805-7 2013 For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01). dss 173-176 serpin family B member 3 Homo sapiens 18-21 23970140-1 2013 The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. Nitric Oxide 58-70 serpin family B member 3 Homo sapiens 208-211 23970140-1 2013 The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. Malondialdehyde 111-128 serpin family B member 3 Homo sapiens 208-211 23970140-1 2013 The aim of the study was a determination of the levels of nitric oxide (NO) and its biological markers such as malonyldialdehyde (MDA) and nitrotyrosine in the serum of patients with squamous cell carcinoma (SCC) of the oral cavity and identification of the relationships between NO and those markers. 3-nitrotyrosine 139-152 serpin family B member 3 Homo sapiens 208-211 23970140-9 2013 The compounds formed with the contribution of NO, such as MDA and nitrotyrosine, may lead to cancer progression in patients with SCC of the oral cavity, and contribute to formation of resistance to therapy in these patients as well. 3-nitrotyrosine 66-79 serpin family B member 3 Homo sapiens 129-132 23786770-7 2013 In addition, we report a patient with an FGFR2-mutated oral SCC who responded to the multitargeted tyrosine kinase inhibitor pazopanib. pazopanib 125-134 serpin family B member 3 Homo sapiens 60-63 23291258-7 2013 Patients with squamous cell carcinoma (SCC) histology were more likely to response to the DP regimen than those with adenocarcinoma histology (68% vs. 33%, P = .006). dp 90-92 serpin family B member 3 Homo sapiens 39-42 23986167-2 2013 Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen"s disease show high rates of clearance for these lesions. Aminolevulinic Acid 35-54 serpin family B member 3 Homo sapiens 147-150 23986167-2 2013 Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen"s disease show high rates of clearance for these lesions. Aminolevulinic Acid 56-59 serpin family B member 3 Homo sapiens 147-150 23986167-2 2013 Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen"s disease show high rates of clearance for these lesions. methyl 5-aminolevulinate 65-87 serpin family B member 3 Homo sapiens 147-150 23986167-2 2013 Results from numerous studies with aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) for the treatment of AKs, SCC, and Bowen"s disease show high rates of clearance for these lesions. mal 89-92 serpin family B member 3 Homo sapiens 147-150 23949352-3 2013 OBJECTIVE: To compare the oncologic and functional outcomes of patients with recurrent oropharyngeal SCC treated with TORS with those treated with traditional open surgical approaches. tors 118-122 serpin family B member 3 Homo sapiens 101-104 23949352-6 2013 PARTICIPANTS Sixty-four patients who underwent salvage TORS for recurrent oropharyngeal SCC were matched by TNM stage to 64 patients who underwent open salvage resection. tors 55-59 serpin family B member 3 Homo sapiens 88-91 23949352-7 2013 INTERVENTION OR EXPOSURE: Salvage TORS for recurrent SCC of the oropharynx. tors 34-38 serpin family B member 3 Homo sapiens 53-56 23949352-12 2013 This adds to the growing amount of clinical evidence to support the use of TORS in selected patients with recurrent oropharyngeal SCC as a feasible and oncologically sound method of treatment. tors 75-79 serpin family B member 3 Homo sapiens 130-133 23314555-6 2013 A significant correlation was also observed between levels of squamous cell carcinoma (SCC) in serum and PaO2 and PA-aO2 (r=-0.49 p=0.01 and r=-0.51, p=0.01, respectively). pao2 105-109 serpin family B member 3 Homo sapiens 87-90 23314555-6 2013 A significant correlation was also observed between levels of squamous cell carcinoma (SCC) in serum and PaO2 and PA-aO2 (r=-0.49 p=0.01 and r=-0.51, p=0.01, respectively). pa-ao2 114-120 serpin family B member 3 Homo sapiens 87-90 24130588-5 2013 In this study, histopathologic differentiation and proliferation activity (by Ki67) in oral SCC lesions of young patient (<40 years) and old patients (>50 years) have been compared. ki67 78-82 serpin family B member 3 Homo sapiens 92-95 24061459-13 2013 This method is simple and cost effective and can easily be done in formaline-fixed paraffin embedded tissues in a clinical laboratory for grading CIN and SCC lesions in cervix. Formaldehyde 67-76 serpin family B member 3 Homo sapiens 154-157 23369463-7 2013 T-cadherin-deficient SCC or human keratinocyte cells exhibited increased transendothelial migration in vitro which could be attenuated in the presence of EGFR inhibitor gefitinib. Gefitinib 169-178 serpin family B member 3 Homo sapiens 21-24 23761568-4 2013 Herein we report a case with Scc-GB complicated with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) treated with mozavaptan. mozavaptan 134-144 serpin family B member 3 Homo sapiens 29-32 23761568-12 2013 Mozavaptan was effective for improvement of hyponatraemia in this patient with Scc-GB complicated with SIADH. mozavaptan 0-10 serpin family B member 3 Homo sapiens 79-82 23290343-9 2013 In addition, the inclusion of patients with N2 or N3 disease will help to determine whether the addition of docetaxel, cisplatin and 5-fluorouracil to CRT reduces the incidence of distant relapse in advanced laryngeal SCC. Docetaxel 108-117 serpin family B member 3 Homo sapiens 218-221 23290343-9 2013 In addition, the inclusion of patients with N2 or N3 disease will help to determine whether the addition of docetaxel, cisplatin and 5-fluorouracil to CRT reduces the incidence of distant relapse in advanced laryngeal SCC. Cisplatin 119-128 serpin family B member 3 Homo sapiens 218-221 23274534-7 2013 OS after 2 and 5 years was 29 and 14 % for SCC patients versus 17 and 3 % for AC patients (P = 0.044). Osmium 0-2 serpin family B member 3 Homo sapiens 43-46 23348836-1 2013 Invasive squamous cell carcinoma (SCC) of the skin is one of the most common cancers in the United States, with no proven means for prevention other than systemic retinoids, which have significant toxicity, and sunscreen. Retinoids 163-172 serpin family B member 3 Homo sapiens 34-37 23667679-1 2013 Chromoendoscopy with Lugol iodine staining provides important information on the development of squamous cell carcinoma (SCC). Lugol's solution 21-33 serpin family B member 3 Homo sapiens 121-124 23266722-3 2013 The sequential administration of DMBA and TPA leads to the appearance of a large number of benign papillomas, of which some convert later into invasive squamous cell carcinomas (SCC). 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 33-37 serpin family B member 3 Homo sapiens 178-181 23266722-3 2013 The sequential administration of DMBA and TPA leads to the appearance of a large number of benign papillomas, of which some convert later into invasive squamous cell carcinomas (SCC). Tetradecanoylphorbol Acetate 42-45 serpin family B member 3 Homo sapiens 178-181 23290343-9 2013 In addition, the inclusion of patients with N2 or N3 disease will help to determine whether the addition of docetaxel, cisplatin and 5-fluorouracil to CRT reduces the incidence of distant relapse in advanced laryngeal SCC. Fluorouracil 133-147 serpin family B member 3 Homo sapiens 218-221 23373651-5 2013 This paper reviews over forty articles that examine cell lines, murine models, and human results for the response of taxol against squamous cell carcinoma (SCC) of the oral cavity and the tongue. Paclitaxel 117-122 serpin family B member 3 Homo sapiens 156-159 23613870-7 2013 Interestingly, both DRC and SCC were resistant to paclitaxel in comparison to parental Hep3B cells. Paclitaxel 50-60 serpin family B member 3 Homo sapiens 28-31 23575356-8 2013 RESULTS: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship. Chromium 80-82 serpin family B member 3 Homo sapiens 44-47 23575356-8 2013 RESULTS: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship. Copper 84-86 serpin family B member 3 Homo sapiens 44-47 23575356-8 2013 RESULTS: For males, the trend test for lung SCC incidence caused by exposure to Cr, Cu, Hg, Ni, and Zn showed a statistically significant dose-response relationship. Zinc 100-102 serpin family B member 3 Homo sapiens 44-47 23575356-10 2013 As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC. Chromium 111-113 serpin family B member 3 Homo sapiens 167-170 23575356-10 2013 As for females, those achieving a statistically significant dose-response relationship for the trend test were Cr (P = 0.02), Ni (P = 0.02), and Zn (P= 0.02) for lung SCC, and Cu (P < 0.01) and Zn (P = 0.02) for lung AC. Zinc 145-147 serpin family B member 3 Homo sapiens 167-170 23525614-5 2013 Dsg3 and E-cadherin expression (SI, CS) was significantly decreased (P < .05) in ASCC compared with SCC, whereas staining for syndecan-1 was similar in the 2 tumor types. Cesium 36-38 serpin family B member 3 Homo sapiens 85-88 23428654-3 2013 The previous studies found that Res can promote apoptosis of a variety of tumor cell, especially SCC cells. Resveratrol 32-35 serpin family B member 3 Homo sapiens 97-100 23358973-6 2013 The tumor burden of SCC was reduced during the 2-year follow-up period in those receiving sirolimus (0.82 v 1.38 per year; HR, 0.51; 95% CI, 0.32 to 0.82; P = .006) if adjusted for the number of previous SCCs and age. Sirolimus 90-99 serpin family B member 3 Homo sapiens 20-23 23478628-7 2013 Bisulfite sequencing analysis confirmed methylation as a frequent event in SCC. hydrogen sulfite 0-9 serpin family B member 3 Homo sapiens 75-78 23274910-5 2013 Moreover, somatic FBW7 mutation in SCC is associated with stabilized Mcl-1 and high Bim levels, resulting in a poor response to standard chemotherapy but a robust response to HDAC inhibitors and enhanced synergy with the combination vorinostat/ABT-737. Vorinostat 233-243 serpin family B member 3 Homo sapiens 35-38 22525043-9 2013 Alcohol consumption could increase the aggressiveness of SCC, leading to reduced expression of E-cadherin. Alcohols 0-7 serpin family B member 3 Homo sapiens 57-60 23274910-3 2013 Treatment with the histone deacetylase (HDAC) inhibitor vorinostat regulates Bcl-2 family member expression to disable the Mcl-1 axis and thereby induce apoptosis in SCC cells. Vorinostat 56-66 serpin family B member 3 Homo sapiens 166-169 23274910-5 2013 Moreover, somatic FBW7 mutation in SCC is associated with stabilized Mcl-1 and high Bim levels, resulting in a poor response to standard chemotherapy but a robust response to HDAC inhibitors and enhanced synergy with the combination vorinostat/ABT-737. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 244-247 serpin family B member 3 Homo sapiens 35-38 23552670-2 2013 We report what we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomavirus subtype 17 (HPV-17) were associated with cutaneous SCC that developed during treatment with the BRAF inhibitor dabrafenib. dabrafenib 225-235 serpin family B member 3 Homo sapiens 165-168 23370431-7 2013 Functional analysis of these genes suggests that oxidative phosphorylation, mitochondrial dysfunction and the polyamine regulation pathways are involved in the pathogenesis of SCC. Polyamines 110-119 serpin family B member 3 Homo sapiens 176-179 23582168-2 2013 METHODS: We describe a 68-year-old man who developed rapid squamous cell carcinoma (SCC) on the resurfaced areas 3 weeks following CO(2) laser resurfacing. Carbon Dioxide 131-136 serpin family B member 3 Homo sapiens 84-87 22450746-7 2013 In conclusion, Traf6 has two important roles in SCC invasion: it promotes cell intrinsic Cdc42-dependent regulation of the actin cytoskeleton and enables production of the paracrine signal, TNFalpha, that enhances the activity of CAFs. cafs 230-234 serpin family B member 3 Homo sapiens 48-51 23446297-7 2013 The authors describe successful outcomes after vismodegib treatment in a patient with basal cell nevus syndrome with numerous bulky lesions of the eyelid and periocular region and erlotinib (EGFR inhibitor) treatment in a patient with SCC who was deemed not to be a good surgical candidate because of advanced SCC of the orbit with metastasis to the regional lymph nodes, advanced age, and multiple medical comorbidities. Erlotinib Hydrochloride 180-189 serpin family B member 3 Homo sapiens 235-238 23125227-4 2013 Diclofenac, a COX-2 inhibitor and non-steroidal anti-inflammatory drug, currently is prescribed to patients as a short-term therapeutic agent to induce SCC precursor lesion regression. Diclofenac 0-10 serpin family B member 3 Homo sapiens 152-155 23106545-3 2013 METHODS: A total of 51 patients with SCC of the anterior oropharyngeal wall received intra-arterial administration of docetaxel at 60 mg/m(2) and cisplatin at 60 mg/m(2) anterogradely, followed by intravenous continuous infusion of 5-fluorouracil at 750 mg/m(2)/day over 120 h starting on day 2. Docetaxel 118-127 serpin family B member 3 Homo sapiens 37-40 23125227-10 2013 Our data suggest a new therapeutic use for currently available topical diclofenac as a preventative intervention for patients predisposed to cutaneous SCC development before lesions appear. Diclofenac 71-81 serpin family B member 3 Homo sapiens 151-154 23509735-9 2013 SCC cells of recessive dystrophic EB (RDEB) accumulate less hypericin or PpIX than nonmalignant RDEB cells. hypericin 60-69 serpin family B member 3 Homo sapiens 0-3 23223314-1 2013 BACKGROUND: Conversion to sirolimus from calcineurin inhibitor- (CNI), azathioprine- (AZA) and mycophenolate-based regimens reduces the risk of development of squamous cell carcinoma of the skin (SCC) in kidney transplant recipients (KTRs). Sirolimus 26-35 serpin family B member 3 Homo sapiens 196-199 23223314-1 2013 BACKGROUND: Conversion to sirolimus from calcineurin inhibitor- (CNI), azathioprine- (AZA) and mycophenolate-based regimens reduces the risk of development of squamous cell carcinoma of the skin (SCC) in kidney transplant recipients (KTRs). Azathioprine 71-83 serpin family B member 3 Homo sapiens 196-199 23223314-1 2013 BACKGROUND: Conversion to sirolimus from calcineurin inhibitor- (CNI), azathioprine- (AZA) and mycophenolate-based regimens reduces the risk of development of squamous cell carcinoma of the skin (SCC) in kidney transplant recipients (KTRs). Azathioprine 86-89 serpin family B member 3 Homo sapiens 196-199 23223314-1 2013 BACKGROUND: Conversion to sirolimus from calcineurin inhibitor- (CNI), azathioprine- (AZA) and mycophenolate-based regimens reduces the risk of development of squamous cell carcinoma of the skin (SCC) in kidney transplant recipients (KTRs). Mycophenolic Acid 95-108 serpin family B member 3 Homo sapiens 196-199 23223314-9 2013 At 6 months, sirolimus conversion reduces new SCC/year, rate ratio 0.49 (95%CI: 0.15-1.63), P = 0.276. Sirolimus 13-22 serpin family B member 3 Homo sapiens 46-49 23549458-2 2013 Chronic arsenic exposure results in various types of human skin lesions, including squamous cell carcinoma (SCC). Arsenic 8-15 serpin family B member 3 Homo sapiens 108-111 23055190-3 2013 A model of lung SCC induced with N-nitrosodiethylamine (NDEA) in recipient female mice transplanted with green fluorescent protein (GFP)-positive BMDCs from male donors was established. Diethylnitrosamine 33-54 serpin family B member 3 Homo sapiens 16-19 23055190-3 2013 A model of lung SCC induced with N-nitrosodiethylamine (NDEA) in recipient female mice transplanted with green fluorescent protein (GFP)-positive BMDCs from male donors was established. Diethylnitrosamine 56-60 serpin family B member 3 Homo sapiens 16-19 23509735-9 2013 SCC cells of recessive dystrophic EB (RDEB) accumulate less hypericin or PpIX than nonmalignant RDEB cells. protoporphyrin IX 73-77 serpin family B member 3 Homo sapiens 0-3 22722579-4 2013 A similar pattern of sensitivity was observed when we exposed the SCC cells to hydrogen peroxide or hypericin photodynamic treatment, which both generate mainly oxidative stress. Hydrogen Peroxide 79-96 serpin family B member 3 Homo sapiens 66-69 23573140-3 2013 Mechanistic studies on human cutaneous squamous cell carcinoma (SCC) cell line SCC12 highlighted the involvement of apoptosis in subamolide B-induced cytotoxicity, as evidenced by the activation of caspases-8, -9, -4, and -3, the increase in annexin V-positive population, and the partial restoration of cell viability by cotreatment with the pan-caspase inhibitor z-VAD-fmk. subamolide B 129-141 serpin family B member 3 Homo sapiens 64-67 23573140-7 2013 Our findings further implicate the potential of subamolide B for cutaneous SCC therapy or as a lead compound for developing novel chemotherapeutic agents. subamolide B 48-60 serpin family B member 3 Homo sapiens 75-78 22828925-7 2013 Treatment with 5-aza-deoxycytidine and trichostatin A synergistically recovered the miR-124/-214 down-regulation in SCC cell line. Decitabine 15-34 serpin family B member 3 Homo sapiens 116-119 22828925-7 2013 Treatment with 5-aza-deoxycytidine and trichostatin A synergistically recovered the miR-124/-214 down-regulation in SCC cell line. trichostatin A 39-53 serpin family B member 3 Homo sapiens 116-119 22949076-8 2013 CR was registered in 3 of 8, 5 of 8 and 10 of 17 treated patients who were affected by extra-mammary Paget"s disease (EMPD), erythroplasia of Queyrat (QD), and invasive squamous cell carcinoma (SCC), respectively. Chromium 0-2 serpin family B member 3 Homo sapiens 194-197 22722579-4 2013 A similar pattern of sensitivity was observed when we exposed the SCC cells to hydrogen peroxide or hypericin photodynamic treatment, which both generate mainly oxidative stress. hypericin 100-109 serpin family B member 3 Homo sapiens 66-69 22734006-2 2012 This cross-sectional study investigated whether patients with oral and oropharyngeal squamous cell carcinoma (SCC) show changes in cortisol levels in saliva and plasma compared with three control groups, and evaluated its correlation with clinicopathological data. Hydrocortisone 131-139 serpin family B member 3 Homo sapiens 110-113 23349993-7 2013 A multivariate regression analysis of the data from the training cohort indicated that serum SCC-ag level is an independent factor for neo-adjuvant chemotherapy (NACT) response. nact 162-166 serpin family B member 3 Homo sapiens 93-96 22736150-12 2012 Our case illustrates that: (1) although rare, in the salivary glands SCC may arise from lower grade neoplasms including PAs; (2) SCC ex PA may metastasize as pure SCC even if the primary SCC component was focal; (3) adequate sampling of PAs is crucial to prevent missing a rare SCC that must be treated with chemotherapy. Protactinium 120-123 serpin family B member 3 Homo sapiens 69-72 23026948-0 2012 Transplantation: Sirolimus for secondary SCC prevention in renal transplantation. Sirolimus 17-26 serpin family B member 3 Homo sapiens 41-44 22736150-12 2012 Our case illustrates that: (1) although rare, in the salivary glands SCC may arise from lower grade neoplasms including PAs; (2) SCC ex PA may metastasize as pure SCC even if the primary SCC component was focal; (3) adequate sampling of PAs is crucial to prevent missing a rare SCC that must be treated with chemotherapy. Protactinium 237-240 serpin family B member 3 Homo sapiens 129-132 22736150-12 2012 Our case illustrates that: (1) although rare, in the salivary glands SCC may arise from lower grade neoplasms including PAs; (2) SCC ex PA may metastasize as pure SCC even if the primary SCC component was focal; (3) adequate sampling of PAs is crucial to prevent missing a rare SCC that must be treated with chemotherapy. Protactinium 237-240 serpin family B member 3 Homo sapiens 129-132 22736150-12 2012 Our case illustrates that: (1) although rare, in the salivary glands SCC may arise from lower grade neoplasms including PAs; (2) SCC ex PA may metastasize as pure SCC even if the primary SCC component was focal; (3) adequate sampling of PAs is crucial to prevent missing a rare SCC that must be treated with chemotherapy. Protactinium 237-240 serpin family B member 3 Homo sapiens 129-132 22736150-12 2012 Our case illustrates that: (1) although rare, in the salivary glands SCC may arise from lower grade neoplasms including PAs; (2) SCC ex PA may metastasize as pure SCC even if the primary SCC component was focal; (3) adequate sampling of PAs is crucial to prevent missing a rare SCC that must be treated with chemotherapy. Protactinium 237-240 serpin family B member 3 Homo sapiens 129-132 23957098-2 2012 The aetiology, clinical presentation and overall prognosis differ from conventional tobacco and alcohol related SCC of the oral cavity. Alcohols 96-103 serpin family B member 3 Homo sapiens 112-115 23957098-9 2012 Older patients with a history of tobacco usage and alcohol consumption may also present with conventional SCC of the oropharynx. Alcohols 51-58 serpin family B member 3 Homo sapiens 106-109 22901105-1 2012 BACKGROUND: CO(2) transoral laser surgery and radiotherapy are both recognized as acceptable treatments for early glottic squamous cell carcinoma (SCC) with similar rates of cure. co(2) 12-17 serpin family B member 3 Homo sapiens 147-150 22734006-5 2012 RESULTS: The plasma (p<0.05) and salivary (p<0.01) cortisol levels were significantly higher in patients with oral SCC compared with all groups. Hydrocortisone 57-65 serpin family B member 3 Homo sapiens 121-124 22734006-6 2012 Patients with oropharyngeal SCC had higher levels of salivary cortisol compared with smokers and/or drinkers (p<0.05) and patients with leukoplakia (p<0.01). Hydrocortisone 62-70 serpin family B member 3 Homo sapiens 28-31 22734006-7 2012 Patients with advanced-stage oral SCC showed significantly higher levels of cortisol than those in an initial clinical stage. Hydrocortisone 76-84 serpin family B member 3 Homo sapiens 34-37 22954172-7 2012 Sensitivity increased significantly for NAB combined with cytological tumor markers compared with NAB alone (CYFRA 21-1: 95% versus 83.5%, p < 0.001, CEA: 92.1% versus 83.5%, p = 0.002, SCC: 91.4% versus 83.5%, p = 0.003). nab 40-43 serpin family B member 3 Homo sapiens 189-192 22763500-10 2012 We observed a mild reduction in SCC risk in current acetaminophen users (RR = 0.88, 95 % CI 0.75-1.02), with a linear decrease in risk with greater frequency of use (p = 0.04). Acetaminophen 52-65 serpin family B member 3 Homo sapiens 32-35 23139668-3 2012 We present a case of tonsillar SCC successfully treated with induction chemotherapy using carboplatin and etoposide followed by concurrent chemoradiation therapy with cisplatin as radiosensitizer. Carboplatin 90-101 serpin family B member 3 Homo sapiens 31-34 23139668-3 2012 We present a case of tonsillar SCC successfully treated with induction chemotherapy using carboplatin and etoposide followed by concurrent chemoradiation therapy with cisplatin as radiosensitizer. Etoposide 106-115 serpin family B member 3 Homo sapiens 31-34 23139668-3 2012 We present a case of tonsillar SCC successfully treated with induction chemotherapy using carboplatin and etoposide followed by concurrent chemoradiation therapy with cisplatin as radiosensitizer. Cisplatin 167-176 serpin family B member 3 Homo sapiens 31-34 22516123-1 2012 The uptake of (18)O by scC(16)O(2) in mixtures containing liquid H(2)(18)O was followed with Raman spectroscopy using a specially designed high-pressure optical cell. Oxygen 30-34 serpin family B member 3 Homo sapiens 23-26 22971315-8 2012 CONCLUSION: Although conjunctival SCC has been described following cyclosporine treatment for organ transplantation, this report describes a case of conjunctival SCC following lower-dose cyclosporine treatment for psoriasis in a patient who had previous psoralen plus ultraviolet A (PUVA) treatment. Cyclosporine 187-199 serpin family B member 3 Homo sapiens 162-165 21923839-3 2012 Few retrospective studies have reported the increased risk of development of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) associated with GC use. gallocatechol 154-156 serpin family B member 3 Homo sapiens 133-136 21923839-12 2012 Among any time prednisone users, the adjusted HR was 1.11 (95% CI, 0.87-1.42) for BCC, and 1.05 (95% CI, 0.76-1.45) for SCC. Prednisone 15-25 serpin family B member 3 Homo sapiens 120-123 21923839-13 2012 Among those who used prednisone for 30 or more days, the HR was 1.26 (95% CI, 0.90-1.78) for BCC, and 1.03 (95% CI, 0.66-1.60) for SCC. Prednisone 21-31 serpin family B member 3 Homo sapiens 131-134 22971315-8 2012 CONCLUSION: Although conjunctival SCC has been described following cyclosporine treatment for organ transplantation, this report describes a case of conjunctival SCC following lower-dose cyclosporine treatment for psoriasis in a patient who had previous psoralen plus ultraviolet A (PUVA) treatment. Cyclosporine 67-79 serpin family B member 3 Homo sapiens 34-37 22971315-8 2012 CONCLUSION: Although conjunctival SCC has been described following cyclosporine treatment for organ transplantation, this report describes a case of conjunctival SCC following lower-dose cyclosporine treatment for psoriasis in a patient who had previous psoralen plus ultraviolet A (PUVA) treatment. Cyclosporine 187-199 serpin family B member 3 Homo sapiens 34-37 22974873-3 2012 This retrospective study evaluated the outcome of renal transplant recipients followed by the Renal Unit with posttransplant diagnosis of SCC treated with conversion from calcineurin inhibitors (CNIs) to Everolimus (EVR) associated with low-dose cyclosporine. Everolimus 204-214 serpin family B member 3 Homo sapiens 138-141 22974873-3 2012 This retrospective study evaluated the outcome of renal transplant recipients followed by the Renal Unit with posttransplant diagnosis of SCC treated with conversion from calcineurin inhibitors (CNIs) to Everolimus (EVR) associated with low-dose cyclosporine. Everolimus 216-219 serpin family B member 3 Homo sapiens 138-141 22974873-7 2012 Conversion from CNIs to EVR has been proven safe, effective, and associated with low recurrence of SCC in patients with a CCl >40 mL/min. Everolimus 24-27 serpin family B member 3 Homo sapiens 99-102 22881582-8 2012 Ciprofloxacin was also associated with SCC (OR 0 34) and thiazines with BCC (OR 2 04), but these associations lost significance after correction for multiple testing. Ciprofloxacin 0-13 serpin family B member 3 Homo sapiens 39-42 22516123-1 2012 The uptake of (18)O by scC(16)O(2) in mixtures containing liquid H(2)(18)O was followed with Raman spectroscopy using a specially designed high-pressure optical cell. h(2)(18)o 65-74 serpin family B member 3 Homo sapiens 23-26 22484291-2 2012 Voriconazole, which is associated with phototoxic side effects in some patients, may be an additional risk factor for SCC in this population. Voriconazole 0-12 serpin family B member 3 Homo sapiens 118-121 22484291-6 2012 RESULTS: Exposure to voriconazole was associated with a 2.6-fold increased risk for SCC. Voriconazole 21-33 serpin family B member 3 Homo sapiens 84-87 22484291-8 2012 At 5 years after transplant, voriconazole conferred an absolute risk increase for SCC of 28%. Voriconazole 29-41 serpin family B member 3 Homo sapiens 82-85 22484291-9 2012 CONCLUSIONS: These results suggest that caution should be taken when using voriconazole in LTR because this drug increases the already high risk for SCC in this population. Voriconazole 75-87 serpin family B member 3 Homo sapiens 149-152 22665619-5 2012 Reviews of both the pathophysiology of SCC and the mechanism of action of Sb(v) revealed that a common pathway (glutathione) may have resulted in the SCC. Glutathione 112-123 serpin family B member 3 Homo sapiens 150-153 22420950-3 2012 The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients. Erlotinib Hydrochloride 52-61 serpin family B member 3 Homo sapiens 98-101 22420950-14 2012 CONCLUSIONS: A significant proportion of lung SCC patients would derive a clinical benefit from erlotinib treatment. Erlotinib Hydrochloride 96-105 serpin family B member 3 Homo sapiens 46-49 22648798-4 2012 Here, we find that in vivo, the alpha-catenin homologue-alpha-catulin, a protein originally reported to interact with Lbc Rho guanine nucleotide exchange factor, is highly expressed at the tumor invasion front and in the metastatic streams of cells in both malignant hHNSCCs and a mouse model of oral SCC. Guanine Nucleotides 126-144 serpin family B member 3 Homo sapiens 270-273 22665619-3 2012 We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis (SCC). Meglumine 86-95 serpin family B member 3 Homo sapiens 140-143 22665619-6 2012 ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb(v), and SCC. Glutathione 194-205 serpin family B member 3 Homo sapiens 218-221 22665619-5 2012 Reviews of both the pathophysiology of SCC and the mechanism of action of Sb(v) revealed that a common pathway (glutathione) may have resulted in the SCC. sb(v) 74-79 serpin family B member 3 Homo sapiens 150-153 21505765-9 2012 SCC- WMH showed the highest correlation (r = -0.413, p = 0.0002) and was the best regional predictor of CR decline (OR = 1.5, r(2) = 0.3). Chromium 104-106 serpin family B member 3 Homo sapiens 0-8 22526373-4 2012 Arsenic promoted SCC apoptosis with increased reactive oxygen species (ROS) production and JNK1/2 and caspase-3 activation (apoptotic pathway). Arsenic 0-7 serpin family B member 3 Homo sapiens 17-20 22526373-4 2012 Arsenic promoted SCC apoptosis with increased reactive oxygen species (ROS) production and JNK1/2 and caspase-3 activation (apoptotic pathway). Reactive Oxygen Species 46-69 serpin family B member 3 Homo sapiens 17-20 22526373-5 2012 In contrast, arsenic also inhibited SCC apoptosis with increased NF-kappaB activity and X-linked inhibitor of apoptosis protein (XIAP) expression level and decreased JNK activity (antiapoptotic pathway). Arsenic 13-20 serpin family B member 3 Homo sapiens 36-39 22526373-6 2012 These results suggest that arsenic bidirectionally promotes apoptotic and antiapoptotic pathways in SCC cells. Arsenic 27-34 serpin family B member 3 Homo sapiens 100-103 22526373-8 2012 Since the anticancer effect of arsenic is mainly dependent on cancer apoptosis, barium-mediated inhibition of arsenic-induced apoptosis may promote progression of SCC in patients in Bangladesh who keep drinking barium and arsenic-polluted water after the development of cancer. Barium 80-86 serpin family B member 3 Homo sapiens 163-166 22526373-8 2012 Since the anticancer effect of arsenic is mainly dependent on cancer apoptosis, barium-mediated inhibition of arsenic-induced apoptosis may promote progression of SCC in patients in Bangladesh who keep drinking barium and arsenic-polluted water after the development of cancer. Arsenic 110-117 serpin family B member 3 Homo sapiens 163-166 22526373-8 2012 Since the anticancer effect of arsenic is mainly dependent on cancer apoptosis, barium-mediated inhibition of arsenic-induced apoptosis may promote progression of SCC in patients in Bangladesh who keep drinking barium and arsenic-polluted water after the development of cancer. Arsenic 110-117 serpin family B member 3 Homo sapiens 163-166 22737961-5 2012 RESULTS: Of the 65 patients with oral SCC, 34% were allergic to at least 1 adjacent metal. Metals 84-89 serpin family B member 3 Homo sapiens 38-41 22737961-7 2012 CONCLUSIONS: Patients with oral SCC who have metal dental restorations should undergo patch testing and possible removal of the restorations if their reactions are positive. Metals 45-50 serpin family B member 3 Homo sapiens 32-35 21505765-10 2012 The SCC- WMH was more than five times larger in the CR-decline group compared to the no-decline group (p = 0.0003). Chromium 52-54 serpin family B member 3 Homo sapiens 4-12 21505765-11 2012 The SCC- WMH (top quartile) showed a higher sensitivity/specificity for CR decline compared to change in total WMH, 63/88% versus 52/84%, respectively. Chromium 72-74 serpin family B member 3 Homo sapiens 4-12 21695460-2 2012 Hsp70 and serpinB3 inhibit a lysosomal cell death pathway induced in anthracycline and taxane treated cells, which may be critical for breast cancer cell survival. Anthracyclines 69-82 serpin family B member 3 Homo sapiens 10-18 21695460-2 2012 Hsp70 and serpinB3 inhibit a lysosomal cell death pathway induced in anthracycline and taxane treated cells, which may be critical for breast cancer cell survival. taxane 87-93 serpin family B member 3 Homo sapiens 10-18 21695460-7 2012 Furthermore, serpinB3 positivity predicted poor survival in patients treated with anthracycline-based chemotherapy alone (P = 0.02), but those with serpinB3 negative tumours had as equally good survival as those also treated with docetaxel (P = 0.7). Anthracyclines 82-95 serpin family B member 3 Homo sapiens 13-21 21695460-11 2012 Furthermore, serpinB3 status in residual tumour is a biomarker of neoadjuvant docetaxel benefit in patients not achieving a pCR and use of serpinB3 molecular subtyping for adjuvant docetaxel treatment planning warrants further investigation. Docetaxel 78-87 serpin family B member 3 Homo sapiens 13-21 21376492-8 2012 CONCLUSIONS: There are significant differences in the DCE parameters which show the potential for distinguishing UD from SCC or lymphoma. ethylene dichloride 54-57 serpin family B member 3 Homo sapiens 121-124 21885222-1 2012 OBJECTIVE: The use of iodine staining has been recommended for the early detection of squamous cell carcinoma (SCC) in the upper aerodigestive tract. Iodine 22-28 serpin family B member 3 Homo sapiens 111-114 21885222-12 2012 Sensitivity and specificity of iodine staining for detecting SCC were 100% and 59.6%, respectively. Iodine 31-37 serpin family B member 3 Homo sapiens 61-64 21885222-18 2012 CONCLUSION: The use of iodine staining as a part of otolaryngological examinations may be beneficial for the early detection of CFOM, including carcinoma in situ and micro-invasive SCC. Iodine 23-29 serpin family B member 3 Homo sapiens 181-184 22297537-1 2012 BACKGROUND: To evaluate the efficacy of surgical excision, cryotherapy and topical Mitomycin C (MMC) for ocular surface squamous cell carcinoma (SCC) with at least 24 months follow-up. Mitomycin 105-116 serpin family B member 3 Homo sapiens 167-170 22264671-3 2012 OBJECTIVE: We sought to determine the association of certain squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) risk with exposure to PUVA. puva 144-148 serpin family B member 3 Homo sapiens 86-89 22264671-12 2012 Exposure to fewer than 150 PUVA treatments has, at most, modest effects on SCC risk. puva 27-31 serpin family B member 3 Homo sapiens 75-78 23960993-6 2012 CONCLUSIONS: The most useful stains in ruling out SCC in a suspected case of MECC were shown to be mucicarmine and the glycosaminoglycan (GAG) stains. mucicarmine 99-110 serpin family B member 3 Homo sapiens 50-53 23960993-6 2012 CONCLUSIONS: The most useful stains in ruling out SCC in a suspected case of MECC were shown to be mucicarmine and the glycosaminoglycan (GAG) stains. Glycosaminoglycans 119-136 serpin family B member 3 Homo sapiens 50-53 23960993-6 2012 CONCLUSIONS: The most useful stains in ruling out SCC in a suspected case of MECC were shown to be mucicarmine and the glycosaminoglycan (GAG) stains. Glycosaminoglycans 138-141 serpin family B member 3 Homo sapiens 50-53 22238275-6 2012 From the photoluminescent spectra, the peak intensity ratio between the purple light (from ZnO at the wavelength 377 nm) and the green band (from the autofluorescence of cells) is much higher with the presence in SCC, as compared with Hs68. Zinc Oxide 91-94 serpin family B member 3 Homo sapiens 213-216 22297537-1 2012 BACKGROUND: To evaluate the efficacy of surgical excision, cryotherapy and topical Mitomycin C (MMC) for ocular surface squamous cell carcinoma (SCC) with at least 24 months follow-up. Mitomycin 118-121 serpin family B member 3 Homo sapiens 167-170 22297537-17 2012 CONCLUSION: The combination of surgical excision, cryotherapy, and post-operative topical mitomycin-C was effective treatment for ocular surface invasive SCC in long-term follow-up. Mitomycin 112-123 serpin family B member 3 Homo sapiens 176-179 22102174-1 2012 OBJECTIVE: The aim of the present study was to investigate the prognostic significance of FDG uptake measured as maximum standardized uptake value (SUVmax) in primary tumor by positron emission tomography with fluorine-18-fluorodeoxyglucose (FDG-PET/CT) and pretreatment serum squamous cell carcinoma antigen (SCC-ag) in patients with cervical cancer. Fluorodeoxyglucose F18 90-93 serpin family B member 3 Homo sapiens 310-313 22086679-2 2012 In this study, we evaluate the topical N-nitroso-tris-chloroethylurea (NTCU) murine SCC model, determine the extent to which resulting premalignant airway dysplasia develops, discuss clinicopathologic grading criteria in lesion progression, and confirm that immunohistochemical (IHC) staining patterns are consistent with those observed in human endobronchial dysplasia and SCC. N-nitroso-tris-chloroethylurea 71-75 serpin family B member 3 Homo sapiens 84-87 22135048-2 2012 We previously showed that dietary freeze-dried, or lyophilized, strawberry powder inhibits N-nitrosomethylbenzylamine-induced SCC in the rat esophagus. nitrosobenzylmethylamine 91-117 serpin family B member 3 Homo sapiens 126-129 22253016-15 2012 CONCLUSIONS: OR-SP PO-IMRT for patients with oral tongue SCC resulted in a significant decrease in the severity of acute mucositis and improved quality of life. or-sp 13-18 serpin family B member 3 Homo sapiens 57-60 21968428-10 2012 The interaction of nitrosative and oxidative stress generated tyrosine nitration, which affected the tumor marker Serpin B3, ATP synthesis and cytoskeleton. Tyrosine 62-70 serpin family B member 3 Homo sapiens 114-123 23230394-5 2012 In the whole group of oral squamous cell carcinoma (SCC), a significant negative correlation was seen between miR-125b and p53 as well as a significant correlation between TP53 mutation status and miR-125b. mir-125b 110-118 serpin family B member 3 Homo sapiens 52-55 24578956-1 2012 A case of a 30-year-old female patient diagnosed with mucinous tubular and spindle cell carcinoma (MT&SCC) of her left kidney of the basis of an abdominal ultrasound scan performed when nonspecific pain is presented. mt& 99-105 serpin family B member 3 Homo sapiens 106-109 24578956-2 2012 The histopathology report revealed a classic type of MT&SCC. mt& 53-59 serpin family B member 3 Homo sapiens 60-63 22359459-4 2012 Subsequent in vitro protein-protein interaction assays confirmed the binding activity of FTL to both preS and SCCA1, as well as the formation of triple complex preS-FTL-SCCA1, and narrowed down the binding sites on FTL. Enalapril 160-164 serpin family B member 3 Homo sapiens 169-174 23185467-10 2012 Strong expression of SERPINB3 protein was a prognostic factor for platinum resistance (adjusted OR; odds ratio, 5.94; 95% Confidence Limits, 1.21-29.15), and for poor progression-free survival (PFS; adjusted HR; hazard ratio, 2.07; 95% CI; confidence interval, 1.03-4.41). Platinum 66-74 serpin family B member 3 Homo sapiens 21-29 23185467-11 2012 Therefore, SERPINB3 may play an important role in ovarian carcinogenesis and be a novel biomarker for predicting platinum resistance and a poor prognosis for survival in patients with EOC. Platinum 113-121 serpin family B member 3 Homo sapiens 11-19 22438899-9 2012 Squamous cell carcinoma (SCC) (55.8 vs. 31.7%, p<0.01) is a significant risk factor for NSCLC with active TB. Terbium 109-111 serpin family B member 3 Homo sapiens 25-28 22493740-7 2012 We also found a significantly positive association between plasma 25(OH)D levels and SCC risk after adjusting for the same covariates (OR, highest vs. lowest quartile = 3.77, 95% CI = 1.70-8.36, P for trend= 0.0002). 25(oh)d 66-73 serpin family B member 3 Homo sapiens 85-88 21844426-11 2011 The 25-OHD levels were similarly positively associated, though statistically insignificant, with NMSC occurring on less UV-exposed anatomical locations (adjusted OR, 2.2; 95% CI, 0.7-7.0), whether for SCC (adjusted OR, 3.2; 95% CI, 0.4-24.0) or for BCC, although the risk estimate for BCC was lower (adjusted OR, 1.7; 95% CI, 0.5-5.8). 25-ohd 4-10 serpin family B member 3 Homo sapiens 201-204 21871142-4 2011 Milk yield, lactose, protein, non casein nitrogen, microbial features were affected by SCC level. Lactose 12-19 serpin family B member 3 Homo sapiens 87-90 22038018-4 2011 Pharmacological, clinical, and experimental animal studies as well as a few epidemiological studies document the importance of PG signaling in non-melanoma skin cancer including SCC and basal cell carcinoma (BCC) in humans and mice. Prostaglandins 127-129 serpin family B member 3 Homo sapiens 178-181 21301917-7 2011 Paclitaxel-carboplatin administration may be an effective treatment for primary SCC of the ovary but further studies are required to investigate it true efficacy in the treatment of this disease. Paclitaxel 0-10 serpin family B member 3 Homo sapiens 80-83 21301917-7 2011 Paclitaxel-carboplatin administration may be an effective treatment for primary SCC of the ovary but further studies are required to investigate it true efficacy in the treatment of this disease. Carboplatin 11-22 serpin family B member 3 Homo sapiens 80-83 22234066-1 2011 BACKGROUND/AIMS: The removed length of the esophagus by transhiatal distal esophagectomy (THDE) for patients with squamous cell carcinoma (SCC) and Barrett"s adenocarcinoma (BAC) in the distal/abdominal esophagus was investigated. thde 90-94 serpin family B member 3 Homo sapiens 139-142 21523761-11 2011 CONCLUSIONS: Although thyroid cartilage penetration is a common route of ELS of glottic and supraglottic SCC, ELS into surrounding structures with thyroid cartilage penetration was found to occur in only 44% of the cases of ELS in the current study. N-[(2S,3S,4R)-3,4-dihydroxy-8-oxo-8-[(4-pentylphenyl)amino]-1-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octan-2-yl]hexacosanamide 73-76 serpin family B member 3 Homo sapiens 105-108 21871142-4 2011 Milk yield, lactose, protein, non casein nitrogen, microbial features were affected by SCC level. Nitrogen 41-49 serpin family B member 3 Homo sapiens 87-90 21229356-1 2011 PURPOSE: The aim of this study was to evaluate the feasibility and toxicity of concurrent chemoradiotherapy (CCRT) with docetaxel, cisplatin (CDDP) and 5-fluorouracil (5-FU) (TPF regimen) or with CDDP, 5-FU, methotrexate and leucovorin (PFML regimen) in previously untreated patients with advanced oropharyngeal squamous cell carcinoma (SCC). Fluorouracil 152-166 serpin family B member 3 Homo sapiens 337-340 21229356-10 2011 CONCLUSION: CCRT with TPF or PFML regimen for advanced oropharyngeal SCC is tolerable and effective, especially in patients with resectable disease. TPF 22-25 serpin family B member 3 Homo sapiens 69-72 21410769-2 2011 The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens. Formaldehyde 158-166 serpin family B member 3 Homo sapiens 173-176 21769085-5 2011 Here, we examine the role of beta4 integrin serine phosphorylation in SCC. Serine 44-50 serpin family B member 3 Homo sapiens 70-73 21769085-12 2011 Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration. Alanine 71-79 serpin family B member 3 Homo sapiens 37-40 21769085-12 2011 Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration. Aspartic Acid 193-202 serpin family B member 3 Homo sapiens 37-40 21769085-12 2011 Mutation of S(1356)S(1360)S(1364) in SCC cells to non-phosphorylatable alanines stabilized HD-like structures and substantially reduced migration, while mutation into phosphorylation mimicking aspartate reduced HD-like structures but had no effect on migration, suggesting that serine phosphorylation function is releasing anchorage rather than promoting migration. Serine 278-284 serpin family B member 3 Homo sapiens 37-40 21769085-13 2011 Altogether these results suggest that beta4 serine phosphorylation may have an important role during SCC invasion by destabilizing HDs and facilitating migration. Serine 44-50 serpin family B member 3 Homo sapiens 101-104 21991576-7 2011 The degree of expression of &amp;#946;-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion &amp;#8804; 50%. Adenosine Monophosphate 33-36 serpin family B member 3 Homo sapiens 87-90 21991576-5 2011 The clinicopathological variables of the IPs with SCC correlated with the degree of expression of E-cadherin and &amp;#946;-catenin. Adenosine Monophosphate 114-117 serpin family B member 3 Homo sapiens 50-53 21991576-5 2011 The clinicopathological variables of the IPs with SCC correlated with the degree of expression of E-cadherin and &amp;#946;-catenin. Adenosine Monophosphate 118-121 serpin family B member 3 Homo sapiens 50-53 21991576-6 2011 RESULTS: The degree of expression of E-cadherin and &amp;#946;-catenin in the cell membrane was significantly lower in IPs with SCC than in nasal polyps and IPs. Adenosine Monophosphate 53-56 serpin family B member 3 Homo sapiens 132-135 21991576-6 2011 RESULTS: The degree of expression of E-cadherin and &amp;#946;-catenin in the cell membrane was significantly lower in IPs with SCC than in nasal polyps and IPs. Adenosine Monophosphate 57-60 serpin family B member 3 Homo sapiens 132-135 21991576-7 2011 The degree of expression of &amp;#946;-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion &amp;#8804; 50%. Adenosine Monophosphate 29-32 serpin family B member 3 Homo sapiens 87-90 21991576-7 2011 The degree of expression of &amp;#946;-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion &amp;#8804; 50%. Adenosine Monophosphate 33-36 serpin family B member 3 Homo sapiens 87-90 21991576-7 2011 The degree of expression of &amp;#946;-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion &amp;#8804; 50%. Adenosine Monophosphate 33-36 serpin family B member 3 Homo sapiens 87-90 21991576-7 2011 The degree of expression of &amp;#946;-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion &amp;#8804; 50%. Adenosine Monophosphate 33-36 serpin family B member 3 Homo sapiens 87-90 21050273-10 2011 We conclude that oral capecitabine significantly decreases the incidence rates of recurrent SCC, BCC, and AK in SOTRs and is associated with manageable toxicity. Capecitabine 22-34 serpin family B member 3 Homo sapiens 92-95 21529996-4 2011 RESULTS: Use of NSAIDs, particularly aspirin, was associated with a reduced odds ratio (OR) of SCC, especially tumors positive for p53 (OR 0.29; 95% confidence interval 0.11-0.79) or with PTCH loss of heterozygosity (OR 0.35; 95% confidence interval 0.13-0.96). Aspirin 37-44 serpin family B member 3 Homo sapiens 95-98 21529996-5 2011 Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Acetaminophen 120-131 serpin family B member 3 Homo sapiens 80-83 21529996-5 2011 Although not considered a NSAID, decreased ORs of both basal cell carcinoma and SCC were observed in relation to use of paracetamol (acetaminophen). Acetaminophen 133-146 serpin family B member 3 Homo sapiens 80-83 21529996-8 2011 CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC. Aspirin 61-68 serpin family B member 3 Homo sapiens 103-106 21529996-8 2011 CONCLUSIONS: This study supports the hypothesis that NSAIDs, aspirin in particular, may reduce risk of SCC and may affect specific molecular subtypes of SCC. Aspirin 61-68 serpin family B member 3 Homo sapiens 153-156 21527555-3 2011 The major protein isoform of p63 expressed in SCC is DeltaNp63alpha, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear. deltanp63alpha 53-67 serpin family B member 3 Homo sapiens 46-49 21527555-3 2011 The major protein isoform of p63 expressed in SCC is DeltaNp63alpha, an N-terminally truncated form which functions as a key SCC cell survival factor by mechanisms that are unclear. deltanp63alpha 53-67 serpin family B member 3 Homo sapiens 125-128 21527555-6 2011 Cisplatin chemotherapy, a mainstay of SCC treatment, promotes dissociation of p63 and HDAC from the PUMA promoter, leading to increased histone acetylation, PUMA activation, and apoptosis. Cisplatin 0-9 serpin family B member 3 Homo sapiens 38-41 21847061-8 2011 The sensitivity increased significantly for NAB combined with a tumor marker compared with NAB alone (100% for CYFRA 21-1, 92.9% for CEA, and 94.2% for SCC; p = 0.001, p = 0.025, and p = 0.014, respectively). nab 44-47 serpin family B member 3 Homo sapiens 152-155 21847061-10 2011 CONCLUSION: Evaluation of tumor markers CYFRA 21-1, CEA, and SCC in the cytological fluid can improve the diagnostic performance of CT-guided NAB for NSCLC. nab 142-145 serpin family B member 3 Homo sapiens 61-64 21616148-5 2011 The inhibitory activity of AmB in all liquid crystal formulations (cholesteryl palmityl carbonate: CPC, dicholesteryl carbonate: DCC and sodium cholesteryl carbonate: SCC) on fungi was significantly enhanced when compared to that of the same amount of pure AmB. Amphotericin B 27-30 serpin family B member 3 Homo sapiens 167-170 22145415-0 2011 [The effect of potassium different concentrations on mRNA expression of protein StAR and cytochrome p-450(SCC) in human adrenocortical tissue]. Potassium 15-24 serpin family B member 3 Homo sapiens 106-109 21886301-6 2011 Almost half of reported cases of renal phosphate wasting associated with SCC concomitantly presented with SIADH. Phosphates 39-48 serpin family B member 3 Homo sapiens 73-76 22145415-1 2011 The effect of different potassium concentrations on changes in steroidogenic acute regulatory protein (StAR) and cytochrome P-450(SCC) in human adrenal cortex tissue was studied. Potassium 24-33 serpin family B member 3 Homo sapiens 113-134 22145415-3 2011 Thus, potassium ions caused an enhancement of minerocorticoid synthesis in the adrenal cortex, which is associated with mechanisms that regulate the intensity of expression of StAR and cytochrome P-450(SCC) on a transcriptional level. Potassium 6-15 serpin family B member 3 Homo sapiens 185-206 21781484-6 2011 The results in our study indicated that there was an additive interaction between low-level of serum folate and high-expression of DNMT1 protein related to the risk of CIN and SCC, with OR value as 2.50 (95%CI: 1.21 - 9.22) and 6.03 (95%CI: 2.79 - 21.72) respectively. Folic Acid 101-107 serpin family B member 3 Homo sapiens 176-179 21711095-1 2011 PURPOSE: The purpose of this study was to assess the potential of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging for detection of the primary tumor and its impact on treatment planning in patients presenting with cancer of unknown primary and squamous cell carcinoma (SCC)-positive cervical lymph nodes of the upper and middle neck. Fluorodeoxyglucose F18 71-90 serpin family B member 3 Homo sapiens 316-319 20949523-11 2011 CONCLUSIONS: Tumor tissue lines established via subrenal capsule xenografting provide models with clinical relevance and the present study suggests that irinotecan could be useful for therapy of refractory prostatic SCC, in particular in combination with cisplatin. Irinotecan 153-163 serpin family B member 3 Homo sapiens 216-219 21502432-11 2011 HC2 may be an effective method of determining HR-HPV status in patients with oropharyngeal SCC. hc2 0-3 serpin family B member 3 Homo sapiens 91-94 22135503-2 2011 Sun exposure, the natural source of vitamin D, is the main risk factor for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Vitamin D 36-45 serpin family B member 3 Homo sapiens 131-134 20070338-3 2011 We evaluate the role of 18fluoro-deoxyglucose (18FDG) combined position emission and computed tomography (PETCT) in the management of anal SCC. 18fluoro-deoxyglucose 24-45 serpin family B member 3 Homo sapiens 139-142 20070338-3 2011 We evaluate the role of 18fluoro-deoxyglucose (18FDG) combined position emission and computed tomography (PETCT) in the management of anal SCC. Fluorodeoxyglucose F18 47-52 serpin family B member 3 Homo sapiens 139-142 21480386-2 2011 In a mouse skin SCC model VILIP-1 expression is reduced in aggressive tumor cells, accompanied by reduced cAMP levels. Cyclic AMP 106-110 serpin family B member 3 Homo sapiens 16-19 21480386-3 2011 Overexpression of VILIP-1 in aggressive SCC cells led to enhanced cAMP production, in turn causing a reduction in invasive properties. Cyclic AMP 66-70 serpin family B member 3 Homo sapiens 40-43 20623130-6 2011 RESULTS: During the study period, 350 SCC patients (mean age 50.3 years) were diagnosed (ASR of 3.8/100,000). asr 89-92 serpin family B member 3 Homo sapiens 38-41 21282955-2 2011 Histological examination with endoscopic biopsies revealed squamous cell carcinoma (SCC), and chromoendoscopy with iodine staining revealed that the superficial SCC involved nearly the entire circumference of the esophageal lumen. Iodine 115-121 serpin family B member 3 Homo sapiens 161-164 21480386-6 2011 We found stronger increase in cGMP levels in aggressive, VILIP-1-negative SCC cells following stimulation of guanylyl cyclases NPR-A and -B with the natriuretic peptides ANP and CNP, respectively. Cyclic GMP 30-34 serpin family B member 3 Homo sapiens 74-77 21480386-10 2011 In contrast, VILIP-1 led to reduced migration of aggressive SCC cells depending on cAMP levels as shown by use of adenylyl cyclase (AC) inhibitor 2",3"-dideoxyadenosine. Cyclic AMP 83-87 serpin family B member 3 Homo sapiens 60-63 21413947-9 2011 CONCLUSIONS: The possibility of rapidly developing actinic keratoses, keratocanthomas, verrucas, and SCC during treatment with sorafenib, warrants close dermatologic follow-up and a lower threshold for biopsy and treatment of suspicious cutaneous lesions. Sorafenib 127-136 serpin family B member 3 Homo sapiens 101-104 21413947-10 2011 Development of a sorafenib-induced SCC is not an absolute contraindication for continued use of sorafenib therapy; however, the drug should be briefly discontinued until lesions are treated. Sorafenib 17-26 serpin family B member 3 Homo sapiens 35-38 21326238-9 2011 CONCLUSION: This is the first TMA study to suggest a clinical association of DEC1 in lymph node metastatic oesophageal SCC, early onset oesophageal SCC and familial oesophageal SCC development. tma 30-33 serpin family B member 3 Homo sapiens 119-122 21326238-9 2011 CONCLUSION: This is the first TMA study to suggest a clinical association of DEC1 in lymph node metastatic oesophageal SCC, early onset oesophageal SCC and familial oesophageal SCC development. tma 30-33 serpin family B member 3 Homo sapiens 148-151 21681703-2 2011 The aim of this study was to investigate risk factors for SCC of the tongue in a set of patients with minimum exposure to cigarette smoking and alcohol. Alcohols 144-151 serpin family B member 3 Homo sapiens 58-61 21712961-4 2011 Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 +- 6.5 ng/mmol creatinine) as compared to the controls (16.9 +- 4.0 ng/mmol creatinine) (P<.001). 8-epi-prostaglandin F2alpha 36-49 serpin family B member 3 Homo sapiens 72-75 20652255-6 2011 Conversely, MTT was lower in SCC than in H (p=0.0009) and M (p=0.0003). monooxyethylene trimethylolpropane tristearate 12-15 serpin family B member 3 Homo sapiens 29-32 21712961-4 2011 Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 +- 6.5 ng/mmol creatinine) as compared to the controls (16.9 +- 4.0 ng/mmol creatinine) (P<.001). Creatinine 106-116 serpin family B member 3 Homo sapiens 72-75 21712961-4 2011 Increased urinary concentrations of 8-isoprostane were also detected in SCC patients (35.4 +- 6.5 ng/mmol creatinine) as compared to the controls (16.9 +- 4.0 ng/mmol creatinine) (P<.001). Creatinine 167-177 serpin family B member 3 Homo sapiens 72-75 20066577-2 2010 To further investigate if cytochrome P-450 cholesterol side-chain cleavage enzyme (P450(scc)) contributes to the overproduction of aldosterone in APA and IHA and if its mRNA expression differs in APA and IHA in patients with primary aldosteronism, we studied the expression of P450(scc) mRNA in APA and idiopathic hyperplastic nodules. Cholesterol 43-54 serpin family B member 3 Homo sapiens 83-92 20809481-6 2010 This method is illustrated by a meta-analysis aimed to estimate the shape of the dose-response curve between alcohol consumption and esophageal squamous cell carcinoma (SCC). Alcohols 109-116 serpin family B member 3 Homo sapiens 169-172 21091787-8 2010 CONCLUSIONS: There could be a potential applicability of FDAP to differentiate premalignant lesions with a tendency to progress into SCC and squamous cutaneous lesions already progressing into early invasive cancer from other squamous cutaneous (pre)malignancies. fdap 57-61 serpin family B member 3 Homo sapiens 133-136 20970593-11 2010 Different immunosuppressive agents have different risks of nonmelanoma skin cancer, as AZA increases the risk of SCC and MMF is a protective factor. Azathioprine 87-90 serpin family B member 3 Homo sapiens 113-116 20920351-1 2010 INTRODUCTION: Of the many different factors associated with an increased risk for oral squamous cell carcinoma (SCC), tobacco and alcohol seem to be the most studied. Alcohols 130-137 serpin family B member 3 Homo sapiens 112-115 20920351-8 2010 CONCLUSION: The group of patients with no tobacco and alcohol use tends toward a higher proportion of females, a higher proportion of patients over 70 years, and a higher number of oral maxillary SCC. Alcohols 54-61 serpin family B member 3 Homo sapiens 196-199 21115940-5 2010 One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). Adenosine Diphosphate Glucose 53-56 serpin family B member 3 Homo sapiens 4-7 21115940-5 2010 One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). Glutamic Acid 58-61 serpin family B member 3 Homo sapiens 4-7 21115940-5 2010 One SCC had a missense mutation at codon 285 (GAG>AAG, Glu>Lys) and the other a nonsense mutation at codon 336, and the leukoplakia had a missense mutation at codon 273 (CGT>CAT, Arg>His). Lysine 65-68 serpin family B member 3 Homo sapiens 4-7 20591690-2 2010 SCC has been reported in immunosuppressed patients receiving voriconazole, but the agent has not been shown to be a risk factor. Voriconazole 61-73 serpin family B member 3 Homo sapiens 0-3 20591690-7 2010 Risk factors for SCC by univariate analysis included older age (p = 0.02), residence in locations with high levels of sun exposure (p = 0.0001), single-lung transplant (p = 0.02) and duration (p = 0.03) and cumulative dose (p = 0.03) of voriconazole. Voriconazole 237-249 serpin family B member 3 Homo sapiens 17-20 20591690-14 2010 CONCLUSIONS: Voriconazole exposure is a risk factor for SCC after lung transplantation, particularly among older patients living in areas with high sun exposure. Voriconazole 13-25 serpin family B member 3 Homo sapiens 56-59 20530655-3 2010 METHODS: This study is a retrospective review of patients treated with topical MMC for ocular surface neoplasia, including primary acquired melanosis (PAM), melanoma, corneal-conjunctival intraepithelial neoplasia (CCIN), squamous cell carcinoma (SCC) and sebaceous gland carcinoma (SGC). Mitomycin 79-82 serpin family B member 3 Homo sapiens 247-250 19930272-1 2010 Rare squamous cell carcinoma (SCC) cases associated with voriconazole therapy have been reported, but this risk may not receive enough consideration from clinicians. Voriconazole 57-69 serpin family B member 3 Homo sapiens 30-33 19930272-2 2010 We describe four patients presenting with multiple SCC while receiving prolonged (two to three years) voriconazole therapy. Voriconazole 102-114 serpin family B member 3 Homo sapiens 51-54 19930272-7 2010 In conclusion, prolonged voriconazole therapy may enhance the risk of photoinduced SCC in immunocompromised patients, and skin monitoring is mandatory. Voriconazole 25-37 serpin family B member 3 Homo sapiens 83-86 20711513-0 2010 An implicit solvent model for SCC-DFTB with Charge-Dependent Radii. dftb 34-38 serpin family B member 3 Homo sapiens 30-33 20684617-3 2010 In this contribution, data from a detailed study of silica speciation and condensation using a model bioinspired silica precursor (silicon catechol complex, SCC) is presented. Silicon Dioxide 52-58 serpin family B member 3 Homo sapiens 157-160 20684617-3 2010 In this contribution, data from a detailed study of silica speciation and condensation using a model bioinspired silica precursor (silicon catechol complex, SCC) is presented. Silicon Dioxide 113-119 serpin family B member 3 Homo sapiens 157-160 20684617-3 2010 In this contribution, data from a detailed study of silica speciation and condensation using a model bioinspired silica precursor (silicon catechol complex, SCC) is presented. silicon catechol 131-147 serpin family B member 3 Homo sapiens 157-160 20711513-1 2010 Motivated by the need of rapidly exploring the potential energy surface of chemical reactions that involve highly charged species, we have developed an implicit solvent model for the approximate density functional theory, SCC-DFTB. dftb 226-230 serpin family B member 3 Homo sapiens 222-225 20711513-6 2010 With analytical first derivatives and favorable computational speed, the SCC-DFTB based solvation model can be effectively used, in conjunction with high-level QM calculations, to explore the mechanism of solution reactions. dftb 77-81 serpin family B member 3 Homo sapiens 73-76 20346029-3 2010 This genetic variant has also been discovered to confer SCC risk in nontransplant patients with low folate status. Folic Acid 100-106 serpin family B member 3 Homo sapiens 56-59 20346029-11 2010 Such findings suggest that intervention in the form of demethylating agents or folate supplementation might be beneficial in the treatment or prevention of SCC. Folic Acid 79-85 serpin family B member 3 Homo sapiens 156-159 20527027-11 2010 Scatter activity was inhibited by an anti-SERPINB3 antibody in a dose-dependent manner and SERPINB3-transfected cells formed a significantly higher number of colonies on soft agar than controls. Agar 175-179 serpin family B member 3 Homo sapiens 91-99 20689797-1 2010 OBJECTIVE: To evaluate the efficacy and risks of complications of pulse dosing of topical 5-fluorouracil (5-FU) in the treatment of corneal intraepithelial neoplasia (CIN), and conjunctival squamous cell carcinoma (SCC). Fluorouracil 90-104 serpin family B member 3 Homo sapiens 215-218 20689797-12 2010 CONCLUSIONS: Adjuvant 1% topical 5-FU appears to be effective in the prevention of recurrence of conjunctival or corneal CIN and SCC after excision biopsy. Fluorouracil 33-37 serpin family B member 3 Homo sapiens 129-132 20659317-0 2010 Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts. Tretinoin 11-15 serpin family B member 3 Homo sapiens 75-78 20507841-21 2010 This study suggests that diclofenac 3% gel is not only an efficient and well tolerated treatment for multiple AKs in OTRs but also may prevent invasive SCC in these high-risk patients. Diclofenac 25-35 serpin family B member 3 Homo sapiens 152-155 20677531-2 2010 Review of the literature reveals few recent studies examining cure rates for ED&C in the treatment of low risk cutaneous SCC. Einsteinium 77-79 serpin family B member 3 Homo sapiens 125-128 20677531-2 2010 Review of the literature reveals few recent studies examining cure rates for ED&C in the treatment of low risk cutaneous SCC. Adenosine Monophosphate 80-83 serpin family B member 3 Homo sapiens 125-128 20677531-3 2010 OBJECTIVE: To evaluate via two retrospective studies the efficacy of ED&C in the treatment of low risk cutaneous SCC. O-ethyl-S(2)-diisopropylaminoethylmethyl phosphorothiolate 69-75 serpin family B member 3 Homo sapiens 117-120 20677531-4 2010 METHODS: A small controlled study in a Veterans Administration teaching hospital dermatology clinic compared cure rates of low risk SCC at one year by ED&C to those of surgical excision. Einsteinium 151-153 serpin family B member 3 Homo sapiens 132-135 20677531-8 2010 CONCLUSION: These findings support the efficacy of ED&C as a treatment modality for low-risk cutaneous SCC. O-ethyl-S(2)-diisopropylaminoethylmethyl phosphorothiolate 51-57 serpin family B member 3 Homo sapiens 107-110 20334941-9 2010 Three-year CSS was 98% for SCC and 100% for BCC. thiocysteine 11-14 serpin family B member 3 Homo sapiens 27-30 20564339-4 2010 Analyzing this robust data set according to biofunctional pathways using DAVID, transcriptional control elements using oPOSSUM, and chromosomal location using GSEA suggested genetic and epigenetic mechanisms of gene expression regulation in SCC. gsea 159-163 serpin family B member 3 Homo sapiens 241-244 19889154-8 2010 CONCLUSION: Cyclic PDT with 5-aminolevulinic acid may reduce the incidence of SCC in SOTRs. 5-amino levulinic acid 28-49 serpin family B member 3 Homo sapiens 78-81 20508272-3 2010 We present a case of primary SCC of the thyroid: this 88-year-old male patient had a history of hyperthyroidism which was treated with radioactive iodine 25 years earlier. radioactive iodine 135-153 serpin family B member 3 Homo sapiens 29-32 20413767-1 2010 PURPOSE: To quantify fluorine 18 ((18)F) fluorodeoxyglucose (FDG) uptake in the palatine tonsils to identify a sensitive and specific metric for distinguishing physiologic asymmetric uptake from squamous cell carcinoma (SCC). Fluorodeoxyglucose F18 61-64 serpin family B member 3 Homo sapiens 220-223 19628343-1 2010 PURPOSE: To determine the feasibility and efficacy of preoperative concurrent chemoradiation therapy (CCRT) with S-1, an oral fluoropyrimidine derivative, in patients with T4 oral squamous cell carcinoma (SCC). 2-fluoropyrimidine 126-142 serpin family B member 3 Homo sapiens 205-208 20459569-9 2010 CONCLUSIONS: Some (48.33%) NAH in HBV-associated cirrhosis, particularly all those with SCC, are already neoplastic lesions. Niacin 27-30 serpin family B member 3 Homo sapiens 88-91 20459569-10 2010 Occurrence of SCC is a late event during NAH progression, suggesting a premalignant phenotype. Niacin 41-44 serpin family B member 3 Homo sapiens 14-17 20455382-6 2010 Reduction of immunosuppression, switch to mTOR inhibitors and chemoprevention with acitretin may reduce the incidence of SCC. Acitretin 83-92 serpin family B member 3 Homo sapiens 121-124 19959474-5 2010 The presence of heparin accelerated inhibition of cathepsin L by both serpins, and in the case of SCCA-1, heparin increased the second order inhibition rate constant from 5.4 x 10(5) to >10(8), indicating a rate enhancement of at least 180-fold. Heparin 106-113 serpin family B member 3 Homo sapiens 98-104 20036604-3 2010 SCC-15 cells maintained under distinct culture conditions expressed high levels of pro-MMP-2 and pro-MMP-9; however, as determined by zymography and Western blot analysis, Dox significantly reduced the production of pro-MMP-2 and pro-MMP-9 after 24h of treatment in a dose-dependent manner (2.5-40 microg/ml). Doxycycline 172-175 serpin family B member 3 Homo sapiens 0-3 20036604-6 2010 On the other hand, daily administration of Dox (3mg/mice) restrained tumor growth in SCC-15 xenografted nude mice, with an inhibition rate of 85.6%. Doxycycline 43-46 serpin family B member 3 Homo sapiens 85-88 20036604-8 2010 In conclusion, reduced expression of MMP-9 at the transcriptional level and MMP-2 at the post-transcriptional level caused by Dox was found to be associated with decreased invasion of oral SCC in vitro. Doxycycline 126-129 serpin family B member 3 Homo sapiens 189-192 20222764-4 2010 The modeled structure of the enzyme was used for docking selective inhibitors (nucleotide analogs and the non-nucleoside inhibitor aphidicolin) in its active site in order to design new drugs for actinic keratosis and squamous cell carcinoma (SCC). Nucleosides 110-120 serpin family B member 3 Homo sapiens 243-246 20222764-4 2010 The modeled structure of the enzyme was used for docking selective inhibitors (nucleotide analogs and the non-nucleoside inhibitor aphidicolin) in its active site in order to design new drugs for actinic keratosis and squamous cell carcinoma (SCC). Aphidicolin 131-142 serpin family B member 3 Homo sapiens 243-246 20031284-6 2010 Lugol"s iodine is a simple, inexpensive, and apparently effective means of reducing the likelihood of unsatisfactory surgical margins in the resection of oral and oropharyngeal SCC. Iodine 8-14 serpin family B member 3 Homo sapiens 177-180 19959474-7 2010 Furthermore, SCCA-1 inhibition of cathepsin L-like proteolytic activity secreted from breast and melanoma cancer cell lines was significantly enhanced by heparin. Heparin 154-161 serpin family B member 3 Homo sapiens 13-19 20236590-3 2010 The differentiation of SCC cells were induced with all-trans-retinoic acid (ATRA). Tretinoin 51-74 serpin family B member 3 Homo sapiens 23-26 20022553-5 2010 In the 4-nitroquinoline 1-oxide (4NQO)-induced oro-esophageal cancer model in mice, ZSP (10% in diet) also significantly reduced the incidence of tongue SCC from 55.2% (16/29) to 22.2% (6/27) (P<0.05), and slightly reduced the incidence of esophageal SCC from 34.5% (10/29) to 22.2% (6/27). ZSP 84-87 serpin family B member 3 Homo sapiens 153-156 20022553-5 2010 In the 4-nitroquinoline 1-oxide (4NQO)-induced oro-esophageal cancer model in mice, ZSP (10% in diet) also significantly reduced the incidence of tongue SCC from 55.2% (16/29) to 22.2% (6/27) (P<0.05), and slightly reduced the incidence of esophageal SCC from 34.5% (10/29) to 22.2% (6/27). ZSP 84-87 serpin family B member 3 Homo sapiens 254-257 20236590-3 2010 The differentiation of SCC cells were induced with all-trans-retinoic acid (ATRA). Tretinoin 76-80 serpin family B member 3 Homo sapiens 23-26 19398252-2 2010 Paraffin sections of primary SCC of the tongue and normal mucosa were screened immunohistochemically for Notch1 and EGFR proteins. Paraffin 0-8 serpin family B member 3 Homo sapiens 29-32 19412906-2 2010 Geometries for the excited-state calculations were extracted from ground-state molecular dynamics (MD) simulations using the self-consistent-charge density functional tight binding (SCC-DFTB) method for the QM region and the TIP3P force field for the water environment. dftb 186-190 serpin family B member 3 Homo sapiens 182-185 19412906-7 2010 Three effects contribute: the use of SCC-DFTB-based rather than B3LYP-based geometries in the MD snapshots (red shift of ca. dftb 41-45 serpin family B member 3 Homo sapiens 37-40 19896749-8 2010 LIMITATIONS: The retrospective nature of the study cannot determine the true population risk of SCC associated with voriconazole therapy. Voriconazole 116-128 serpin family B member 3 Homo sapiens 96-99 20980789-1 2010 INTRODUCTION: We describe our experience with sorafenib and sunitinib in the treatment of chemotherapy-refractory advanced penile squamous cell carcinoma (SCC). Sorafenib 46-55 serpin family B member 3 Homo sapiens 155-158 21058193-2 2010 Cox proportional hazards models describe the relationship between dose quartiles of isotretinoin and retinol use and time to first occurrence of squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) in crude and adjusted models. Isotretinoin 84-96 serpin family B member 3 Homo sapiens 170-173 21058193-2 2010 Cox proportional hazards models describe the relationship between dose quartiles of isotretinoin and retinol use and time to first occurrence of squamous cell carcinoma (SCC) or basal cell carcinoma (BCC) in crude and adjusted models. Vitamin A 101-108 serpin family B member 3 Homo sapiens 170-173 21058193-4 2010 Crude and adjusted retinol models show a statistically significant increase in risk of developing an SCC in the first quartile, whereas only the crude model shows a statistically significant increase in risk in the first quartile of the isotretinoin model. Vitamin A 19-26 serpin family B member 3 Homo sapiens 101-104 20980789-1 2010 INTRODUCTION: We describe our experience with sorafenib and sunitinib in the treatment of chemotherapy-refractory advanced penile squamous cell carcinoma (SCC). Sunitinib 60-69 serpin family B member 3 Homo sapiens 155-158 20980789-10 2010 The patient who achieved partial response had an SCC antigen reduction of nearly 95% after treatment with sunitinib. Sunitinib 106-115 serpin family B member 3 Homo sapiens 49-52 20980789-12 2010 CONCLUSIONS: The feasibility and activity of sorafenib and sunitinib in our series suggest that this approach may be a promising alternative in chemotherapy-refractory advanced penile SCC. Sorafenib 45-54 serpin family B member 3 Homo sapiens 184-187 20980789-12 2010 CONCLUSIONS: The feasibility and activity of sorafenib and sunitinib in our series suggest that this approach may be a promising alternative in chemotherapy-refractory advanced penile SCC. Sunitinib 59-68 serpin family B member 3 Homo sapiens 184-187 20026854-7 2009 Fluorouracil use produced the following clearance rates: 90% for superficial BCC and 27% to 85% for SCC in situ. Fluorouracil 0-12 serpin family B member 3 Homo sapiens 100-103 20026854-10 2009 CONCLUSIONS: Evidence supports the use of topical imiquimod as monotherapy for superficial BCC and topical fluorouracil as monotherapy for superficial BCC and SCC in situ. Fluorouracil 107-119 serpin family B member 3 Homo sapiens 159-162 19727729-5 2009 METHODS: From June 1999 to December 2008, 32 patients affected by SCC were treated in our institution with chemotherapy containing Fluoropyrimidine and platinum salt concomitant with pelvic radiotherapy. 2-fluoropyrimidine 131-147 serpin family B member 3 Homo sapiens 66-69 19727729-5 2009 METHODS: From June 1999 to December 2008, 32 patients affected by SCC were treated in our institution with chemotherapy containing Fluoropyrimidine and platinum salt concomitant with pelvic radiotherapy. platinum salt 152-165 serpin family B member 3 Homo sapiens 66-69 19764999-9 2009 Folate concentrations and methylation of LINE-1, RASSF1, and RUNX3 were significantly higher in adenocarcinoma compared to squamous cell carcinoma (SCC). Folic Acid 0-6 serpin family B member 3 Homo sapiens 148-151 19837302-11 2009 In all the patients with SCC, a lowered ability of neutrophils to generate superoxide anion radicals and an increased production of cyclic guanosine monophosphate by PMNs and PBMCs was confirmed. Superoxides 75-100 serpin family B member 3 Homo sapiens 25-28 20043461-4 2009 Prospective data from a preplanned subgroup analysis of a phase III study and retrospective reviews consistently reported a significant interaction between treatment by histology and response/survival in nonsquamous NSCLCs treated with pemetrexed, compared to squamous cell carcinoma (SCC). Pemetrexed 236-246 serpin family B member 3 Homo sapiens 285-288 20043461-5 2009 Thymidylate synthase, the main target of pemetrexed, was found to be differentially expressed among the histotypes of lung cancer, being lower in adenocarcinoma and higher in SCC and small-cell lung cancer. Pemetrexed 41-51 serpin family B member 3 Homo sapiens 175-178 20032389-7 2009 MATERIALS AND METHODS: Radio-sensitization to carbon-ion radiotherapy when combined with a novel HDACI cyclic hydroxamic-acid-containing peptide 31(CHAP31) was assessed in human esophageal SCC both in vitro and in vivo. cyclic hydroxamic-acid 103-125 serpin family B member 3 Homo sapiens 189-192 20032389-11 2009 CONCLUSION: CHAP31 sensitizes SCC cells to carbon-ion radiotherapy and this combinatory treatment may be a potentially useful therapeutic strategy for esophageal SCC. Carbon 43-49 serpin family B member 3 Homo sapiens 30-33 19837302-11 2009 In all the patients with SCC, a lowered ability of neutrophils to generate superoxide anion radicals and an increased production of cyclic guanosine monophosphate by PMNs and PBMCs was confirmed. Cyclic GMP 132-162 serpin family B member 3 Homo sapiens 25-28 19680830-10 2009 Reduction of immunosuppression and switch to mTOR inhibitors and potentially, mycophenolate, may reduce the incidence of further SCC. Mycophenolic Acid 78-91 serpin family B member 3 Homo sapiens 129-132 19738056-7 2009 However, Aurora-A overexpression combined with exposure to TPA and the mutagen 7,12-dimethylbenz(a)anthracene accelerated SCC development with greater metastatic activity than control mice, indicating that Aurora-A cannot initiate skin carcinogenesis but rather promotes the malignant conversion of skin papillomas. Tetradecanoylphorbol Acetate 59-62 serpin family B member 3 Homo sapiens 122-125 19738056-7 2009 However, Aurora-A overexpression combined with exposure to TPA and the mutagen 7,12-dimethylbenz(a)anthracene accelerated SCC development with greater metastatic activity than control mice, indicating that Aurora-A cannot initiate skin carcinogenesis but rather promotes the malignant conversion of skin papillomas. anthracene 99-109 serpin family B member 3 Homo sapiens 122-125 18624760-3 2009 The aim of this study was to investigate the apoptosis-inducing effect of acitretin on human skin squamous cell carcinoma (SCC) SCL-1 cells. Acitretin 74-83 serpin family B member 3 Homo sapiens 123-126 19384953-8 2009 The TYR Ser192Tyr was associated with SCC risk (OR, 1.23; 95% CI, 1.00-1.50). Tyrosine 4-7 serpin family B member 3 Homo sapiens 38-41 19384953-9 2009 The TYR haplotype carrying only the Arg402Gln variant allele was significantly associated with SCC risk (OR, 1.35; 95% CI, 1.04-1.74). Tyrosine 4-7 serpin family B member 3 Homo sapiens 95-98 19644138-7 2009 CONCLUSIONS: The low HVR levels found in sickle cell anemia and SCC indicates a comparable low oxygen transport potential of blood in both genotypes. Oxygen 95-101 serpin family B member 3 Homo sapiens 64-67 19680830-11 2009 Chemoprevention with the retinoid acitretin reduces the recurrence rate of SCC. Retinoids 25-33 serpin family B member 3 Homo sapiens 75-78 19538055-1 2009 AIM: The aim of this study was to investigate early changes in uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) in vivo and in vitro in a squamous-cell carcinoma (SCC) cell line originating from a human head and neck SCC during cytotoxic therapy with respect to metabolism in tumor cells and in surrounding stromal tissue. 2-deoxy-2-[ 73-84 serpin family B member 3 Homo sapiens 164-167 19378340-1 2009 Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. Alcohols 7-14 serpin family B member 3 Homo sapiens 86-89 19378340-2 2009 In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Alcohols 46-53 serpin family B member 3 Homo sapiens 77-80 19378340-5 2009 Cox regression was applied to model sex-specific associations between lifetime alcohol intake and SCC risk adjusting for potential confounders including smoking. Alcohols 79-86 serpin family B member 3 Homo sapiens 98-101 19378340-10 2009 We observed a stronger association between alcohol intake at lifetime and risk of SCC in women compared to men (p for interaction = 0.045). Alcohols 43-50 serpin family B member 3 Homo sapiens 82-85 19378340-11 2009 The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. Alcohols 47-54 serpin family B member 3 Homo sapiens 115-118 19378340-11 2009 The strong dose-response relation for lifetime alcohol use underscores that alcohol is an important risk factor of SCC of the upper aero-digestive tract throughout life. Alcohols 76-83 serpin family B member 3 Homo sapiens 115-118 19810143-5 2009 The highest percentage of Fas-staining keratinocytes in our survey was identified mostly in H and patients with well-differentiated SCC. ammonium ferrous sulfate 26-29 serpin family B member 3 Homo sapiens 132-135 19451660-7 2009 RESULTS: The Ala/Ala genotype was 27.7% in cancer patients (29.5% AC, 26.6% SCC), 23.1% in patients with heavy alcohol abuse and 12.5% in the group of healthy blood donors. Alanine 13-16 serpin family B member 3 Homo sapiens 76-79 19451660-7 2009 RESULTS: The Ala/Ala genotype was 27.7% in cancer patients (29.5% AC, 26.6% SCC), 23.1% in patients with heavy alcohol abuse and 12.5% in the group of healthy blood donors. Alanine 17-20 serpin family B member 3 Homo sapiens 76-79 19461243-5 2009 We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man. adpa 31-35 serpin family B member 3 Homo sapiens 88-91 19461243-8 2009 This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA. adpa 128-132 serpin family B member 3 Homo sapiens 100-103 19538055-1 2009 AIM: The aim of this study was to investigate early changes in uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) in vivo and in vitro in a squamous-cell carcinoma (SCC) cell line originating from a human head and neck SCC during cytotoxic therapy with respect to metabolism in tumor cells and in surrounding stromal tissue. 2-deoxy-2-[ 73-84 serpin family B member 3 Homo sapiens 218-221 19538055-1 2009 AIM: The aim of this study was to investigate early changes in uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) in vivo and in vitro in a squamous-cell carcinoma (SCC) cell line originating from a human head and neck SCC during cytotoxic therapy with respect to metabolism in tumor cells and in surrounding stromal tissue. ]fluoro-d-glucose 89-106 serpin family B member 3 Homo sapiens 164-167 19442055-4 2009 Natural product, daunorubicin a toxic analogue of anthracycline is reduced to less toxic daunorubicinol by the AKR1B10, enzyme, which is overexpressed in most cases of smoking associate squamous cell carcinoma (SCC) and adenocarcinoma. Anthracyclines 50-63 serpin family B member 3 Homo sapiens 211-214 19241108-6 2009 Survival for T2N0M0 SCC patients was significantly improved with aspirin (71) compared with placebo (167) or no tablet (134) (P = 0.0004). Aspirin 65-72 serpin family B member 3 Homo sapiens 20-23 19442055-4 2009 Natural product, daunorubicin a toxic analogue of anthracycline is reduced to less toxic daunorubicinol by the AKR1B10, enzyme, which is overexpressed in most cases of smoking associate squamous cell carcinoma (SCC) and adenocarcinoma. Daunorubicin 17-29 serpin family B member 3 Homo sapiens 211-214 19164894-4 2009 In this study, we investigated whether the cat L-SCCA 1 lysosomal pathway and autophagy were involved in resveratrol (RSV)-induced cytotoxicity in cervical cancer cells. Resveratrol 105-116 serpin family B member 3 Homo sapiens 49-55 19164894-8 2009 In contrast, inhibition of SCCA 1 by siRNA promoted RSV-induced cytotoxicity. Resveratrol 52-55 serpin family B member 3 Homo sapiens 27-33 19442055-4 2009 Natural product, daunorubicin a toxic analogue of anthracycline is reduced to less toxic daunorubicinol by the AKR1B10, enzyme, which is overexpressed in most cases of smoking associate squamous cell carcinoma (SCC) and adenocarcinoma. daunorubicinol 89-103 serpin family B member 3 Homo sapiens 211-214 18397902-1 2009 Melanin impregnation in squamous cell carcinoma (SCC) is an uncommon histological finding. Melanins 0-7 serpin family B member 3 Homo sapiens 49-52 19336544-6 2009 CONCLUSION: Relatively high serum selenium concentrations are associated with an approximately 60% decrease in subsequent tumor incidence of both BCC and SCC, whereas serum concentrations of carotenoids or alpha-tocopherol are not associated with later skin cancer incidence. Selenium 34-42 serpin family B member 3 Homo sapiens 154-157 19336544-7 2009 A possible U-shaped association between serum selenium concentrations and SCC of the skin needs confirmation. Selenium 46-54 serpin family B member 3 Homo sapiens 74-77 18802697-4 2009 We first demonstrated that the epithelial expression of PGE(2) enzymatic pathways, including cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase 1 (mPGES-1), is higher in SIL and SCC compared to the normal exocervical epithelium and inversely correlated to the density of CD1a-positive LC. Prostaglandins E 56-59 serpin family B member 3 Homo sapiens 192-195 18830627-2 2009 In this in vitro study, we investigated the antitumor effect of bortezomib (Velcade) in combination with cetuximab in squamous cell carcinoma cell lines (SCC). Bortezomib 64-74 serpin family B member 3 Homo sapiens 154-157 18855945-1 2009 A facile route is described for the regioselective conjugation of organo-soluble polymers onto chitosan under very mild conditions, using SCC as intermediates. Polymers 81-89 serpin family B member 3 Homo sapiens 138-141 18855945-2 2009 SCC could be prepared simply by mixing chitosan acidic aqueous solution with SDS. Sodium Dodecyl Sulfate 77-80 serpin family B member 3 Homo sapiens 0-3 18855945-4 2009 In addition, the polymers were found to be linked to chitosan through the hydroxyl groups of chitosan when stoichiometric SCC was used as a precursor. Polymers 17-25 serpin family B member 3 Homo sapiens 122-125 18855945-5 2009 SDS could be removed simply by either precipitating the solution of SCC-graft-polymer in DMSO into Tris aqueous solution or dialyzing against Tris solution. Sodium Dodecyl Sulfate 0-3 serpin family B member 3 Homo sapiens 68-71 18855945-5 2009 SDS could be removed simply by either precipitating the solution of SCC-graft-polymer in DMSO into Tris aqueous solution or dialyzing against Tris solution. Dimethyl Sulfoxide 89-93 serpin family B member 3 Homo sapiens 68-71 18855945-5 2009 SDS could be removed simply by either precipitating the solution of SCC-graft-polymer in DMSO into Tris aqueous solution or dialyzing against Tris solution. Tromethamine 99-103 serpin family B member 3 Homo sapiens 68-71 18814047-9 2009 For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). Arginine 134-137 serpin family B member 3 Homo sapiens 4-7 18814047-9 2009 For SCC, the trend of increased risk across the three genotypes of MDM2 was stronger among p53 Pro carriers (p, trend, 0.05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). Arginine 138-141 serpin family B member 3 Homo sapiens 4-7 18830627-5 2009 RESULTS: Bortezomib alone showed a significant antiproliferative activity in all SCC cell lines (P < 0.042), and the activity was further significantly enhanced by the addition of cetuximab (P < 0.043). Bortezomib 9-19 serpin family B member 3 Homo sapiens 81-84 18830627-6 2009 CONCLUSIONS: Our results indicate that cetuximab increases the cytotoxic activity of bortezomib in SCC cell lines. Bortezomib 85-95 serpin family B member 3 Homo sapiens 99-102 21686921-6 2009 The carcinogenic properties of mineral oils is well recognised and is strongly linked with squamous cell carcinoma (SCC) of the skin, including scrotal carcinoma. Mineral Oil 31-43 serpin family B member 3 Homo sapiens 116-119 19207486-9 2009 RESULTS: Tranexamic acid alone and in combination with CTT1 can inhibit tongue SCC invasion in vitro, at least partially explained by its property of reducing the plasmin-mediated activation of proMMP-9. Tranexamic Acid 9-24 serpin family B member 3 Homo sapiens 79-82 19220630-8 2009 "This relationship may be accounted for by the facts that smoking and use of BQ may induce an alteration to p53 that, in turn, may lead to the development and progression of SCC". bulaquine 77-79 serpin family B member 3 Homo sapiens 174-177 19995713-6 2009 Moreover, DXM injections resulted also in an enhancement (P<0.05) in the level of P450(scc) protein in the walls of small follicles as compared to the control gilts. Dexamethasone 10-13 serpin family B member 3 Homo sapiens 85-94 19213663-5 2009 The time to development of SCC or AK from the start of sorafenib was 9.3 months (median, 6.5 months; range, 0.9-43 months). Sorafenib 55-64 serpin family B member 3 Homo sapiens 27-30 19213663-8 2009 One patient receiving sorafenib at a 25% dose reduction developed a second invasive SCC lesion on his forearm 6 months after the initial resection. Sorafenib 22-31 serpin family B member 3 Homo sapiens 84-87 19213663-9 2009 CONCLUSION: These data suggest that there could be an association between sorafenib therapy and the development of cutaneous SCC and inflammation of AK. Sorafenib 74-83 serpin family B member 3 Homo sapiens 125-128 19213663-2 2009 Cutaneous squamous cell carcinoma (SCC) and inflammation of actinic keratosis (AK) were reported in 2 patients treated with sorafenib (Lacouture et al), but the scope of this observation has not been evaluated. Sorafenib 124-133 serpin family B member 3 Homo sapiens 35-38 19995713-7 2009 Following DXM administration the immunoreactivity (IR) of P450(scc) in the primordial follicles was lower than in the control group. Dexamethasone 10-13 serpin family B member 3 Homo sapiens 58-67 19995713-9 2009 The immunostaining for P450(scc) (theca cells) and P450(arom) (granulosa cells) in the small follicles of the DXM-treated gilts were more prominent than those found in the gonads of control animals. Dexamethasone 110-113 serpin family B member 3 Homo sapiens 23-32 19250408-2 2009 As DPMC is extremely rare, its association with skin squamous cell carcinoma (SCC) is rarer still. 5,8-dihydroxy-2-(2-(4-methoxyphenyl)ethyl)chromone 3-7 serpin family B member 3 Homo sapiens 78-81 19407926-9 2009 ELISA showed that the levels of s-CUEC-23-Abs were significantly higher in patients with esophageal SCC than in healthy volunteers (17% in the former using the mean+3 SD of s-CUEC-23-Abs in healthy controls as the cutoff). s-cuec-23-abs 32-45 serpin family B member 3 Homo sapiens 100-103 19407926-11 2009 s-CUEC-23-Abs might be a useful serum marker to detect esophageal SCC. s-cuec-23-abs 0-13 serpin family B member 3 Homo sapiens 66-69 19333541-2 2009 The aim of this study was to evaluate the effectiveness of combination chemotherapy with carboplatin and etoposide (CE) in SCC of the pancreas. Carboplatin 89-100 serpin family B member 3 Homo sapiens 123-126 19333541-2 2009 The aim of this study was to evaluate the effectiveness of combination chemotherapy with carboplatin and etoposide (CE) in SCC of the pancreas. Etoposide 105-114 serpin family B member 3 Homo sapiens 123-126 19250408-3 2009 To our knowledge there are only two cases of SCC in patients with DPMC that developed within areas of chronic skin ulceration. 5,8-dihydroxy-2-(2-(4-methoxyphenyl)ethyl)chromone 66-70 serpin family B member 3 Homo sapiens 45-48 18813314-8 2008 We found an increased risk of SCC (IRR of 1.79 (95% confidence interval (CI): 1.45-2.21)) and MM (IRR of 1.43 (95% CI: 1.09-1.88)) among users of combined amiloride and hydrochlorothiazide therapy. Amiloride 155-164 serpin family B member 3 Homo sapiens 30-33 19080001-1 2008 BACKGROUND & OBJECTIVE: Patients with advanced squamous cell carcinoma (SCC) of the oral tongue have poor prognosis. Adenosine Monophosphate 12-15 serpin family B member 3 Homo sapiens 76-79 18762997-1 2008 INTRODUCTION: In recent years, there has been an increase in the number of patients with squamous cell carcinoma (SCC) of the mobile tongue in the absence of tobacco and alcohol. Alcohols 170-177 serpin family B member 3 Homo sapiens 114-117 19178683-2 2008 Folate and homocysteine derangements are identified in people diagnosed with head and neck SCC. Folic Acid 0-6 serpin family B member 3 Homo sapiens 91-94 18813314-8 2008 We found an increased risk of SCC (IRR of 1.79 (95% confidence interval (CI): 1.45-2.21)) and MM (IRR of 1.43 (95% CI: 1.09-1.88)) among users of combined amiloride and hydrochlorothiazide therapy. Hydrochlorothiazide 169-188 serpin family B member 3 Homo sapiens 30-33 18554943-3 2008 Histologic examination revealed the malignant component of CXPA was clear cell squamous cell carcinoma (SCC), which is quite uncommon in head and neck region. cxpa 59-63 serpin family B member 3 Homo sapiens 104-107 18284451-3 2008 This study aimed to determine the recommended dosage of nedaplatin plus ifosfamide chemoradiotherapy for advanced squamous cell carcinoma (SCC) of the uterine cervix. nedaplatin 56-66 serpin family B member 3 Homo sapiens 139-142 18284451-3 2008 This study aimed to determine the recommended dosage of nedaplatin plus ifosfamide chemoradiotherapy for advanced squamous cell carcinoma (SCC) of the uterine cervix. Ifosfamide 72-82 serpin family B member 3 Homo sapiens 139-142 18284451-12 2008 Nedaplatin and ifosfamide combination chemotherapy is a feasible and active chemoradiation strategy for patients with advanced SCC of the uterine cervix. Ifosfamide 15-25 serpin family B member 3 Homo sapiens 127-130 18843030-1 2008 BACKGROUND: Because early squamous cell carcinoma (SCC) of the esophagus is detectable by endoscopic esophageal iodine staining with high accuracy and is easily treated by endoscopic mucosectomy, it is important to develop efficient methods for screening candidates for the endoscopic examination. Iodine 112-118 serpin family B member 3 Homo sapiens 51-54 18843030-2 2008 Inactive aldehyde dehydrogenase-2 (ALDH2) is a very strong risk factor for esophageal SCC in alcohol drinkers and thus may be suitable as a screening tool. Alcohols 93-100 serpin family B member 3 Homo sapiens 86-89 18423671-1 2008 BACKGROUND: The addition of gemcitabine may be a reasonable way to enhance the activity of the alternating cisplatin/5-fluorouracil and radiation regimen considered the referring approach for patients with advanced squamous cell carcinoma (SCC) of the head and neck at the National Institute for Cancer Research of Genoa. gemcitabine 28-39 serpin family B member 3 Homo sapiens 240-243 18759990-8 2008 CONCLUSION: MIBC in Upper Egypt is usually of the SCC type (although its percentage is decreasing), occurs at a younger age and presents with burning micturition rather than hematuria. 4-METHYL-2-PENTANOL 12-16 serpin family B member 3 Homo sapiens 50-53 18554943-5 2008 To the best of our knowledge, this is the first case of CXPA of which the malignant component is clear cell SCC. cxpa 56-60 serpin family B member 3 Homo sapiens 108-111 18464261-9 2008 In tongue SCC cell lines, PKM2 expression was reduced in response to miR-133a and miR-133b precursors transfection. mir-133a 69-77 serpin family B member 3 Homo sapiens 10-13 18489606-1 2008 BACKGROUND: Photodynamic therapy (PDT) with methylaminolaevulinate (MAL) is an approved noninvasive treatment option for actinic keratosis and Bowen"s disease (BD), two precursors of invasive squamous cell carcinoma (SCC). methyl 5-aminolevulinate 44-66 serpin family B member 3 Homo sapiens 217-220 18445521-2 2008 The present study was designed to extend preclinical evaluation of the novel camptothecin in human squamous cell carcinoma (SCC) models. Camptothecin 77-89 serpin family B member 3 Homo sapiens 124-127 18429959-1 2008 East Asian case-control studies have shown a strong relationship between alcohol consumption combined with inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) and the development of squamous cell carcinoma (SCC), especially multiple SCC, of the upper aerodigestive tract (UADT). Alcohols 73-80 serpin family B member 3 Homo sapiens 215-218 18429959-1 2008 East Asian case-control studies have shown a strong relationship between alcohol consumption combined with inactive heterozygous aldehyde dehydrogenase-2 (ALDH2*1/*2) and the development of squamous cell carcinoma (SCC), especially multiple SCC, of the upper aerodigestive tract (UADT). Alcohols 73-80 serpin family B member 3 Homo sapiens 241-244 18429959-2 2008 This study aimed to identify determinants of the development of metachronous SCC in the UADT in alcoholics with esophageal SCC. uadt 88-92 serpin family B member 3 Homo sapiens 77-80 18445521-7 2008 In conclusion, ST1968 exhibited an outstanding antitumour activity superior to that of irinotecan against SCC. Irinotecan 87-97 serpin family B member 3 Homo sapiens 106-109 18281778-0 2008 [Remarkably reduced tumor marker SCC levels by combined chemotherapy of paclitaxel and S-1 in two cases of advanced cervical cancer]. Paclitaxel 72-82 serpin family B member 3 Homo sapiens 33-36 18261173-5 2008 Voriconazole therapy has been suggested to be involved in the development of multi-focal invasive SCC when complicated by a phototoxic reaction. Voriconazole 0-12 serpin family B member 3 Homo sapiens 98-101 18058818-2 2008 The purpose of this study was to determine if similar changes occurred in vivo in the tumors of patients with SCC of the esophagus who were given a preferential COX-2 inhibitor, meloxicam. Meloxicam 178-187 serpin family B member 3 Homo sapiens 110-113 18058818-13 2008 We conclude that meloxicam induces apoptosis in SCC of the esophagus in vivo by inhibiting the pathway of NF-kappaB downstream regulation of COX-2. Meloxicam 17-26 serpin family B member 3 Homo sapiens 48-51 18281778-11 2008 In April, 2006, paclitaxel/S-1 therapy was performed, and the tumor markers were reduced remarkably (SCC 120--> 10 ng/mL). Paclitaxel 16-26 serpin family B member 3 Homo sapiens 101-104 18281778-6 2008 In September, paclitaxel/S-1 therapy was performed, and the tumor markers were again reduced remarkably (SCC 9.8--> 1.3 ng/mL). Paclitaxel 14-24 serpin family B member 3 Homo sapiens 105-108 18701820-1 2008 BACKGROUND: The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). Fluorouracil 31-45 serpin family B member 3 Homo sapiens 183-186 17955256-1 2008 Recently, Boron neutron capture therapy (BNCT) was successfully applied to treat experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa, with no damage to normal tissue. Boron 10-15 serpin family B member 3 Homo sapiens 120-123 17392700-1 2008 OBJECTIVE: To investigate the association between total alcohol intake and intake of different types of alcoholic beverages in relation to the risk of basal cell (BCC) and squamous cell (SCC) carcinoma of the skin. Alcohols 56-63 serpin family B member 3 Homo sapiens 187-190 18041071-8 2008 The 5-year OS and CSS rates were 60.9% and 83.5%, respectively, for patients with oral tongue SCC versus 64.7% and 94.1%, respectively, for patients with SCC of other oral cavity subsites (OS: hazard ratio, 1.24; P< .0001; CSS: hazard ratio, 3.04; P< .0001). thiocysteine 18-21 serpin family B member 3 Homo sapiens 94-97 18041071-10 2008 The CSS for patients who had stage I and II oral tongue SCC also was unfavorable compared with the CSS for stage-matched patients who had SCC of other head and neck sites. thiocysteine 4-7 serpin family B member 3 Homo sapiens 56-59 18701820-1 2008 BACKGROUND: The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). Fluorouracil 47-51 serpin family B member 3 Homo sapiens 183-186 18701820-1 2008 BACKGROUND: The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). Cisplatin 54-63 serpin family B member 3 Homo sapiens 183-186 17671677-4 2007 Transfection of the anti-SUMO-1 antisense oligonucleotide to oral SCC cells significantly reduced proliferation of the cells. Oligonucleotides 42-57 serpin family B member 3 Homo sapiens 66-69 20305732-1 2008 Clinical data show a strong correlation between tobacco and alcohol use and the development of oral squamous cell carcinoma (SCC). Alcohols 60-67 serpin family B member 3 Homo sapiens 125-128 18003990-10 2007 CONCLUSION: The promising response rates and tolerability of intraarterial chemotherapy with nanoparticle albumin-bound paclitaxel justify further investigation of this formulation, alone or in combination with other agents, in advanced SCC of the head and neck. Paclitaxel 120-130 serpin family B member 3 Homo sapiens 237-240 17764090-5 2007 Clinical trials show that TB is useful in identifying asymptomatic OSCC and premalignant lesions at risk of progressing to SCC, which might otherwise be undetected until lesions become more advanced. Tolonium Chloride 26-28 serpin family B member 3 Homo sapiens 68-71 17988857-4 2007 High dietary intake of lutein and zeaxanthin was associated with a reduced incidence of SCC in persons who had a history of skin cancer at baseline (highest versus lowest tertile, multivariable adjusted relative risk (RR)=0.47, 95% confidence interval (CI): 0.25-0.89; P for trend=0.02). Zeaxanthins 34-44 serpin family B member 3 Homo sapiens 88-91 17893046-4 2007 The relationships between SCC and urinary 8-oxodG were analyzed by conditional logistic regression and those between 8-oxodG and other candidate variables by linear regression, correcting for the effect of SCC. 8-ohdg 42-49 serpin family B member 3 Homo sapiens 26-29 17893046-5 2007 In SCC patients, urinary 8-oxodG was significantly elevated (p=0.03), both pre- and post-tumor development, compared to non-SCC transplant patients. 8-ohdg 25-32 serpin family B member 3 Homo sapiens 3-6 17786954-6 2007 On multivariate analysis, an elevated serum LDH level and low serum albumin at the time of SCC diagnosis was found to be predictive of inferior progression-free survival (P = .02 and P = .008, respectively) and inferior disease-specific survival (DSS) (P = .02 and P = .01, respectively). dss 247-250 serpin family B member 3 Homo sapiens 91-94 17652209-4 2007 Using fluorescence to monitor uptake, we demonstrated that SCC-25 cell monolayers transport naproxen with a Michaelis constant (K(m)) and maximum velocity (V(max)) of 164 microg/mL and 0.94 ng/min/microg protein, respectively. Naproxen 92-100 serpin family B member 3 Homo sapiens 59-62 17306956-2 2007 Pretreatment FDG uptake was evaluated as a predictor of survival and guidance for primary surgery or radiotherapy (RT) in patients with squamous cell carcinoma (SCC) of the larynx and hypopharynx. Fluorodeoxyglucose F18 13-16 serpin family B member 3 Homo sapiens 161-164 17687223-1 2007 We report our second patient treated successfully with a new combined chemotherapy regimen of intra-arterial pirarubicin and nedaplatin plus intravenous methotrexate and vincristine for squamous cell carcinoma (SCC) of the bladder. pirarubicin 109-120 serpin family B member 3 Homo sapiens 211-214 17687223-1 2007 We report our second patient treated successfully with a new combined chemotherapy regimen of intra-arterial pirarubicin and nedaplatin plus intravenous methotrexate and vincristine for squamous cell carcinoma (SCC) of the bladder. Methotrexate 153-165 serpin family B member 3 Homo sapiens 211-214 17687223-1 2007 We report our second patient treated successfully with a new combined chemotherapy regimen of intra-arterial pirarubicin and nedaplatin plus intravenous methotrexate and vincristine for squamous cell carcinoma (SCC) of the bladder. Vincristine 170-181 serpin family B member 3 Homo sapiens 211-214 17652209-9 2007 Thus, SCC-25 cells possess transporters for naproxen. Naproxen 44-52 serpin family B member 3 Homo sapiens 6-9 17564420-1 2007 The approximate SCC-DFTB method (Elstner, M.; Porezag, D.; Jungnickel, G.; Elsner, J.; Haugk, M.; Frauenheim, Th. dftb 20-24 serpin family B member 3 Homo sapiens 16-19 17627246-6 2007 Folate-sensitive pathways may play a critical role in the elevated rate of SCC in renal transplant recipients. Folic Acid 0-6 serpin family B member 3 Homo sapiens 75-78 17564420-0 2007 SCC-DFTB: what is the proper degree of self-consistency? dftb 4-8 serpin family B member 3 Homo sapiens 0-3 17564420-6 2007 Further, the SCC-DFTB and semiempirical NDDO formalisms are compared to elucidate similarities and differences. dftb 17-21 serpin family B member 3 Homo sapiens 13-16 17578436-1 2007 BACKGROUND: Overexpression of cyclooxygenase-2 (COX-2), resulting in excessive prostaglandin production, has been observed in human epidermal keratinocytes after ultraviolet B injury, in squamous cell skin carcinoma (SCC), in actinic keratoses, and in the early stages of carcinogenesis in a wide variety of tissues. Prostaglandins 79-92 serpin family B member 3 Homo sapiens 217-220 17566705-1 2007 Sulindac exerts its antitumorigenic effects in oral squamous cell carcinoma (SCC) cells by modulating survivin in a Stat3-dependent manner. Sulindac 0-8 serpin family B member 3 Homo sapiens 77-80 17343571-10 2007 Among the patients who gained CR with a previously elevated pretreatment CEA and SCC-Ag, the values were normalized in 92.1% (58/63) and 96.4% (134/139) at 1 month, respectively. Chromium 30-32 serpin family B member 3 Homo sapiens 81-84 17566705-2 2007 Immunohistochemistry was used to detect the protein levels of phosphorylated-tyrosine Stat3 (p-tyr Stat3) and survivin in SCC tissues. Tyrosine 77-85 serpin family B member 3 Homo sapiens 122-125 17566705-2 2007 Immunohistochemistry was used to detect the protein levels of phosphorylated-tyrosine Stat3 (p-tyr Stat3) and survivin in SCC tissues. Tyrosine 77-80 serpin family B member 3 Homo sapiens 122-125 17391904-1 2007 BACKGROUND: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been reported to be superior to computed tomography (CT)/magnetic resonance imaging (MRI) in the evaluation of head and neck cancers, but little is known about its usefulness in oropharyngeal squamous cell carcinoma (SCC). Fluorodeoxyglucose F18 12-34 serpin family B member 3 Homo sapiens 297-300 17566705-8 2007 Transfection of constitutively active Stat3 restored survivin expression and partially rescued SCC cells from sulindac-induced antitumorigenic effects. Sulindac 110-118 serpin family B member 3 Homo sapiens 95-98 17566705-9 2007 These data indicate that survivin is a downstream target and effector of oncogenic Stat3 signalling in SCC, which is targeted by sulindac in a COX-2-independent manner. Sulindac 129-137 serpin family B member 3 Homo sapiens 103-106 17525275-3 2007 Although total ErbB1 protein and mRNA were similar in cancerous and normal skin, we found that ErbB1 activation (phospho-Tyr(1068)) was greater in bulk SCC versus BCC or normal skin. Tyrosine 121-124 serpin family B member 3 Homo sapiens 152-155 17391904-1 2007 BACKGROUND: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been reported to be superior to computed tomography (CT)/magnetic resonance imaging (MRI) in the evaluation of head and neck cancers, but little is known about its usefulness in oropharyngeal squamous cell carcinoma (SCC). Fluorodeoxyglucose F18 36-39 serpin family B member 3 Homo sapiens 297-300 17513803-1 2007 PURPOSE: To conduct a phase III trial of adjuvant 13-cis-retinoic acid (13cRA) plus interferon alfa (IFN-alpha) for preventing tumor recurrence and second primary tumors (SPTs) of skin squamous cell carcinoma (SCC) among patients with aggressive skin SCC. Isotretinoin 50-70 serpin family B member 3 Homo sapiens 210-213 17513803-1 2007 PURPOSE: To conduct a phase III trial of adjuvant 13-cis-retinoic acid (13cRA) plus interferon alfa (IFN-alpha) for preventing tumor recurrence and second primary tumors (SPTs) of skin squamous cell carcinoma (SCC) among patients with aggressive skin SCC. Isotretinoin 72-77 serpin family B member 3 Homo sapiens 210-213 17230518-9 2007 Alcohol interacts with tobacco in a stronger supra-multiplicative way in the middle portion of the esophagus, probably explaining why esophageal SCC occurs more commonly at this anatomical location. Alcohols 0-7 serpin family B member 3 Homo sapiens 145-148 17355262-4 2007 Treatment with ER antagonist (tamoxifen), but not agonist (estradiol), caused apoptotic cell death of SCC cells in a concentration- and time-dependent manner. Tamoxifen 30-39 serpin family B member 3 Homo sapiens 102-105 17355262-5 2007 Adhesion of SCC was inhibited by the treatment with tamoxifen, but not with estradiol. Tamoxifen 52-61 serpin family B member 3 Homo sapiens 12-15 17355262-11 2007 In addition, tamoxifen strongly inhibited invasion of SCC. Tamoxifen 13-22 serpin family B member 3 Homo sapiens 54-57 17291389-4 2007 The study revealed that the pH value and the lactose content of the milk were affected by high SCC and that the coagulation properties were dependent on the somatic cell content. Lactose 45-52 serpin family B member 3 Homo sapiens 95-98 16841033-1 2007 The UV radiation-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) is thought to induce squamous cell carcinoma (SCC) similar to those induced by UV radiation in animals. 4-Nitroquinoline-1-oxide 34-58 serpin family B member 3 Homo sapiens 113-116 17400812-4 2007 We show that tamoxifen (TAM) treatment inhibited cell cycle progression and proliferation of human cancer lines derived from stratified squamous epithelium squamous cell carcinoma (SCC). Tamoxifen 13-22 serpin family B member 3 Homo sapiens 181-184 17400812-4 2007 We show that tamoxifen (TAM) treatment inhibited cell cycle progression and proliferation of human cancer lines derived from stratified squamous epithelium squamous cell carcinoma (SCC). Tamoxifen 24-27 serpin family B member 3 Homo sapiens 181-184 17418248-2 2007 STUDY DESIGN AND SETTING: Five patients with SCC were injected with the 123-iodine-radiolabeled L19(scFv)2 antibody and underwent scintigraphic detection with single photon emission tomography with computerized tomography (SPECT/CT). Iodine-123 72-82 serpin family B member 3 Homo sapiens 45-48 16950800-7 2007 We observed an interaction between the C677T polymorphism and total folate intake on SCC risk (P, interaction=0.04); the highest risk was observed among women with TT genotype and low folate intake (OR=2.14; 95% CI=1.01-4.50). Folic Acid 68-74 serpin family B member 3 Homo sapiens 85-88 16950800-7 2007 We observed an interaction between the C677T polymorphism and total folate intake on SCC risk (P, interaction=0.04); the highest risk was observed among women with TT genotype and low folate intake (OR=2.14; 95% CI=1.01-4.50). Folic Acid 184-190 serpin family B member 3 Homo sapiens 85-88 16950800-9 2007 An interaction between the Bsm1 polymorphism and total vitamin D intake on SCC was observed, with the highest risk seen in women with the BB genotype and high vitamin D intake (OR=2.38; 95% CI=1.22-4.62) (P, interaction=0.08). Vitamin D 55-64 serpin family B member 3 Homo sapiens 75-78 16950800-9 2007 An interaction between the Bsm1 polymorphism and total vitamin D intake on SCC was observed, with the highest risk seen in women with the BB genotype and high vitamin D intake (OR=2.38; 95% CI=1.22-4.62) (P, interaction=0.08). Vitamin D 159-168 serpin family B member 3 Homo sapiens 75-78 16950800-10 2007 This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC. Folic Acid 110-116 serpin family B member 3 Homo sapiens 174-177 16950800-10 2007 This study suggests a possible role of the polymorphisms in MTHFR and VDR interacting with dietary intakes of folate and vitamin D in skin cancer development, especially for SCC. Vitamin D 121-130 serpin family B member 3 Homo sapiens 174-177 17687452-10 2007 In the stratum of subjects who have variant for both XPD polymorphisms, there was a 2-fold increased risk of SCC associated with elevated arsenic (OR = 2.2; 95% CI, 1.0-5.0). Arsenic 138-145 serpin family B member 3 Homo sapiens 109-112 17687452-11 2007 The test for interaction between XPD and arsenic in SCC was of borderline significance (p < 0.07, 3 degrees of freedom). Arsenic 41-48 serpin family B member 3 Homo sapiens 52-55 17019709-2 2007 Tobacco smoking and alcohol use are the most important risk factors in the development of esophageal squamous cell carcinoma (SCC). Alcohols 20-27 serpin family B member 3 Homo sapiens 126-129 17019709-7 2007 Moreover, BPDE induced ATM expression in esophageal SCC cell lines in a time-dependent manner. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10-14 serpin family B member 3 Homo sapiens 52-55 16841033-1 2007 The UV radiation-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) is thought to induce squamous cell carcinoma (SCC) similar to those induced by UV radiation in animals. 4-Nitroquinoline-1-oxide 60-65 serpin family B member 3 Homo sapiens 113-116 17873505-1 2007 OBJECTIVES: We determined serum nitric oxide (NO) levels in patients with head and neck squamous cell carcinoma (SCC) and sought correlations with TNM staging, tumor localization, and tumor grade. Nitric Oxide 32-44 serpin family B member 3 Homo sapiens 113-116 17454960-1 2007 Immunosuppressive therapy with azathioprine has been documented to cause squamous cell carcinoma (SCC) at various sites. Azathioprine 31-43 serpin family B member 3 Homo sapiens 98-101 18497505-6 2007 SCC patients received significantly more of planned cisplatin and radiotherapy doses than ADC patients (82.0 vs. 67.7%, p = 0.042, and 92.5 vs. 84.5%, p = 0.023, respectively). Cisplatin 52-61 serpin family B member 3 Homo sapiens 0-3 17141073-7 2006 HE staining pathology has confirmed that this tumor is a typical SCC. Helium 0-2 serpin family B member 3 Homo sapiens 65-68 17033011-13 2006 Statistically interesting factors (repeatability, recovery rate, and potential matrix effects of milk) proved that the DCC is a useful tool for identifying the SCC of milk samples, and thus of grading udder health status. DICYCLOHEXYLCARBODIIMIDE 119-122 serpin family B member 3 Homo sapiens 160-163 17185196-3 2007 SCC is associated with a lower socioeconomic level with nicotine and alcohol abuse resulting in comorbidities like liver cirrhosis and reduced pulmonary function; in contrast, AEG I is associated with a high socioeconomic level and cardiovascular risk factors. Nicotine 56-64 serpin family B member 3 Homo sapiens 0-3 17147827-4 2006 The current study defined hypericin PDT in vitro with human SCC cells before the cells were grown as tumor transplants in nude mice and tested as a model for hypericin induced tumor fluorescence and PDT via laser fiberoptics. hypericin 26-35 serpin family B member 3 Homo sapiens 60-63 17147827-7 2006 RESULTS: In vitro testing revealed a hypericin dose of 0.2-0.5 microg/ml was needed for PDT of the SCC cells with an optimal tumoricidal response seen at the 593 nm light absorption maximum. hypericin 37-46 serpin family B member 3 Homo sapiens 99-102 17147827-9 2006 CONCLUSION: In this preclinical study, hypericin was tested for 514-593 nm dye laser PDT of human SCC cells in vitro and for KTP532 surgical laser targeting of SCC tumors in mice. hypericin 39-48 serpin family B member 3 Homo sapiens 98-101 17119048-1 2006 Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/*2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol. Alcohols 138-145 serpin family B member 3 Homo sapiens 112-115 17119048-1 2006 Asian case-control studies have shown a strong relationship between the development of squamous cell carcinoma (SCC) of the esophagus and alcohol consumption combined with inactive aldehyde dehydrogenase-2 (ALDH2*1/*2), less-active alcohol dehydrogenase-1B (ADH1B*1/*1), high mean corpuscular volume (MCV), and self-reported facial flushing in response to alcohol. Alcohols 232-239 serpin family B member 3 Homo sapiens 112-115 16527532-1 2006 The optical absorption studies of sodium copper chlorophyllin thin films (SCC), prepared by spray pyrolysis, in the UV-vis-NIR region was reported for the first time. chlorophyllin 34-61 serpin family B member 3 Homo sapiens 74-77 17454960-2 2007 We report possibly the first case of SCC of the kidney in a young male who received azathioprine for a long time. Azathioprine 84-96 serpin family B member 3 Homo sapiens 37-40 16502452-8 2006 The selectivity of the base-analogue pair was reproduced (model B) when their desolvation energy was included with the interaction energy of both strands determined by the approximate SCC-DFTB-D method. dftb 188-192 serpin family B member 3 Homo sapiens 184-187 17051951-13 2006 CONCLUSIONS: Combined modality therapy using platinum-based combination chemotherapy and consolidation radiotherapy may provide effective local control and allow a bladder-preserving approach to the management of SCC of the bladder. Platinum 45-53 serpin family B member 3 Homo sapiens 213-216 16937309-1 2006 We report a case of squamous cell carcinoma (SCC) of the bladder treated successfully with intraarterial chemotherapy using nedaplatin. nedaplatin 124-134 serpin family B member 3 Homo sapiens 45-48 16641895-2 2006 We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Oligonucleotides 13-28 serpin family B member 3 Homo sapiens 264-267 16807664-7 2006 The most common arsenic-induced skin cancers are Bowen"s disease (carcinoma in situ), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Arsenic 16-23 serpin family B member 3 Homo sapiens 142-145 16807664-8 2006 Arsenic-induced Bowen"s disease (As-BD) is able to transform into invasive BCC and SCC. Arsenic 0-7 serpin family B member 3 Homo sapiens 83-86 16844522-2 2006 OBJECTIVE: Our aim was to evaluate the efficacy and tolerability of imiquimod 5% cream for treatment of Bowen"s disease and invasive squamous cell carcinoma (SCC) in patients who were unsuitable candidates for surgery. Imiquimod 68-77 serpin family B member 3 Homo sapiens 158-161 16844522-3 2006 METHOD: Five Bowen"s disease lesions and 7 invasive SCC lesions on 10 patients were treated with imiquimod once daily 5 times a week for a maximum of 16 weeks. Imiquimod 97-106 serpin family B member 3 Homo sapiens 52-55 16844522-8 2006 CONCLUSION: Topical application of imiquimod 5% cream might represent an alternative topical treatment to surgery in selected cases of Bowen"s disease and invasive SCC. Imiquimod 35-44 serpin family B member 3 Homo sapiens 164-167 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Platinum 137-145 serpin family B member 3 Homo sapiens 44-47 16549823-7 2006 SerpinB3 protein expression was correlated with clinical response in PBC-treated NSCLC patients (P = .045). potassium bicarbonate 69-72 serpin family B member 3 Homo sapiens 0-8 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Platinum 137-145 serpin family B member 3 Homo sapiens 87-90 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Platinum 137-145 serpin family B member 3 Homo sapiens 87-90 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Etoposide 146-155 serpin family B member 3 Homo sapiens 44-47 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Etoposide 146-155 serpin family B member 3 Homo sapiens 87-90 16536759-11 2006 CONCLUSIONS: These results indicate that GU SCC is an aggressive cancer; limited-stage SCC of the bladder or prostate, when treated with platinum/etoposide chemotherapy and radical radiotherapy, has a more favourable outcome than that of extensive GU SCC. Etoposide 146-155 serpin family B member 3 Homo sapiens 87-90 16436672-4 2006 Using a pull-down assay, active GTP-bound rap1 was up-regulated in SCC compared to normal or immortalized keratinocytes. Guanosine Triphosphate 32-35 serpin family B member 3 Homo sapiens 67-70 16470182-7 2006 WNT receptor frizzled homolog 6 (FZD6) and prostaglandin-metabolizing enzyme hydroxyprostaglandin dehydrogenase were increased in SCC alone. Prostaglandins 43-56 serpin family B member 3 Homo sapiens 130-133 16520839-4 2006 METHODS: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections. Paraffin 170-178 serpin family B member 3 Homo sapiens 108-111 16525679-8 2006 These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC. Carbon 30-36 serpin family B member 3 Homo sapiens 163-166 16525679-8 2006 These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC. Docetaxel 72-81 serpin family B member 3 Homo sapiens 163-166 16436672-7 2006 Incubation of stably transfected SCC cells with nocodazole, an inhibitor of mitosis, caused a slower accumulation of rap1GAP-transfected cells in the G2 phase, in comparison to the vector control, indicating that rap1GAP-transfected cells have slower progression through the cell cycle. Nocodazole 48-58 serpin family B member 3 Homo sapiens 33-36 16424000-7 2006 The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC. Tetradecanoylphorbol Acetate 75-78 serpin family B member 3 Homo sapiens 250-253 16455631-1 2006 UNLABELLED: Recent studies suggest a somewhat selective uptake of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) in cerebral gliomas and in squamous cell carcinoma (SCC) and a good distinction between tumor and inflammation. O-(2-fluoroethyl)tyrosine 66-99 serpin family B member 3 Homo sapiens 158-161 17458095-2 2006 The aim of our study was to estimate the concentration of TRP and its derivatives, such as anthranilic (AA) and kynurenic acid (KYNA) in plasma, saliva, squamous cell carcinoma (SCC) tissues and healthy oral mucosa in patients with oral SCC. Tryptophan 58-61 serpin family B member 3 Homo sapiens 178-181 16917549-3 2006 Since GSL are known to be tumor-associated markers we decided to perform a prospective study on the GSL profiles of SCC. Glycosphingolipids 6-9 serpin family B member 3 Homo sapiens 116-119 16917549-3 2006 Since GSL are known to be tumor-associated markers we decided to perform a prospective study on the GSL profiles of SCC. Glycosphingolipids 100-103 serpin family B member 3 Homo sapiens 116-119 16917549-7 2006 In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa. CDw17 antigen 54-57 serpin family B member 3 Homo sapiens 3-6 16917549-7 2006 In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa. Globosides 64-73 serpin family B member 3 Homo sapiens 3-6 16917549-7 2006 In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa. gm3 79-82 serpin family B member 3 Homo sapiens 3-6 16917549-8 2006 The identification of GM3 as well as its increased expression in SCC was confirmed unequivocally by HPTLC immunostaining and indirect immunofluorescence using MAb DH2 (anti-GM3). gm3 22-25 serpin family B member 3 Homo sapiens 65-68 16917549-8 2006 The identification of GM3 as well as its increased expression in SCC was confirmed unequivocally by HPTLC immunostaining and indirect immunofluorescence using MAb DH2 (anti-GM3). (-)-taxifolin 163-166 serpin family B member 3 Homo sapiens 65-68 16917549-8 2006 The identification of GM3 as well as its increased expression in SCC was confirmed unequivocally by HPTLC immunostaining and indirect immunofluorescence using MAb DH2 (anti-GM3). gm3 173-176 serpin family B member 3 Homo sapiens 65-68 17458095-2 2006 The aim of our study was to estimate the concentration of TRP and its derivatives, such as anthranilic (AA) and kynurenic acid (KYNA) in plasma, saliva, squamous cell carcinoma (SCC) tissues and healthy oral mucosa in patients with oral SCC. Tryptophan 58-61 serpin family B member 3 Homo sapiens 237-240 16155917-2 2005 METHODS: We evaluated the status of GDM by using monoclonal antibodies specific for 5-methylcytosine (5-mc) in oral squamous cell carcinoma (SCC) specimens of 48 cigarette smokers who had SCC develop and in 93 age-, race-, and sex-matched smokers who did not. 5-Methylcytosine 84-100 serpin family B member 3 Homo sapiens 141-144 16155917-2 2005 METHODS: We evaluated the status of GDM by using monoclonal antibodies specific for 5-methylcytosine (5-mc) in oral squamous cell carcinoma (SCC) specimens of 48 cigarette smokers who had SCC develop and in 93 age-, race-, and sex-matched smokers who did not. 5-Methylcytosine 102-106 serpin family B member 3 Homo sapiens 141-144 16155917-3 2005 RESULTS: Percentages of cells positive for 5-mc immunostaining of DNA of SCC and dysplastic lesions were significantly higher than those of normal oral epithelial cells from cancer subjects and from noncancer subjects. 5-Methylcytosine 43-47 serpin family B member 3 Homo sapiens 73-76 16185283-1 2005 Enhanced prostaglandin production via upregulated cyclooxygenase-2 (COX-2) expression is a likely contributing factor in ultraviolet B (UVB)-induced non-melanoma skin cancer (NMSC), which consists primarily of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Prostaglandins 9-22 serpin family B member 3 Homo sapiens 235-238 16360508-1 2005 OBJECTIVES: To determine the effects of combined radiation and targeted, intra-arterial (IA) cisplatin infusions (RADPLAT) in patients with advanced squamous cell carcinoma (SCC) of the tonsil. Cisplatin 93-102 serpin family B member 3 Homo sapiens 174-177 16277658-7 2005 RESULTS: Protein levels of RARgamma were significantly lower by approximately 68% in SCC compared to normal surrounding tissue in patients with SCC that smoked and/or consumed elevated amounts of alcohol. Alcohols 196-203 serpin family B member 3 Homo sapiens 144-147 16277658-8 2005 Furthermore, RARalpha protein levels were significantly lower (approximately- 45%) in SCC in comparison to normal esophageal mucosa in patients with elevated alcohol intake. Alcohols 158-165 serpin family B member 3 Homo sapiens 86-89 16310056-1 2005 BACKGROUND: Although animal studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, may protect against cutaneous squamous cell carcinoma (SCC) and actinic keratoses (AKs), possible effects on keratinocytic cancers in humans are unknown. Aspirin 106-113 serpin family B member 3 Homo sapiens 170-173 16177546-8 2005 DXM injections resulted in a significant increase in the immunoexpression of P450(scc) and 3beta-HSD in the cysts, a significant increase of P450(scc) in the follicles, and a decrease of 3beta-HSD and P450(arom). Dexamethasone 0-3 serpin family B member 3 Homo sapiens 77-100 16177546-8 2005 DXM injections resulted in a significant increase in the immunoexpression of P450(scc) and 3beta-HSD in the cysts, a significant increase of P450(scc) in the follicles, and a decrease of 3beta-HSD and P450(arom). Dexamethasone 0-3 serpin family B member 3 Homo sapiens 77-85 15687239-5 2005 Major risk factors for the development of SCC were long duration of chronic GVHD therapy (P < .001); use of azathioprine, particularly when combined with cyclosporine and steroids (P < .001); and severe chronic GVHD (P = .004). Azathioprine 111-123 serpin family B member 3 Homo sapiens 42-45 15946810-11 2005 At that concentration, the potency of liposomal bleomycin on causing cell death of SCC cells was found to be similar to that of free bleomycin solution. Bleomycin 48-57 serpin family B member 3 Homo sapiens 83-86 15946810-13 2005 It seems that SCC cells were particularly susceptible to Bleosome containing high levels of bleomycin. Bleomycin 92-101 serpin family B member 3 Homo sapiens 14-17 16225179-6 2005 In both cases brain MRI showed a lesion in the SCC characterized by high signal on T2-weighted images and no enhancement after Gadolinium infusion. Gadolinium 127-137 serpin family B member 3 Homo sapiens 47-50 15946810-9 2005 In vitro data revealed that the LD50 of bleomycin encapsulated in Bleosome was approximately three-fold higher than free bleomycin solution for SCC cells, and nearly 30 times higher for NEB-1 cells. Bleomycin 40-49 serpin family B member 3 Homo sapiens 144-147 15946810-10 2005 However, Bleosome containing 30 microg/ml of active bleomycin killed more than twice as many SCC cells than NEB-1 cells. Bleomycin 52-61 serpin family B member 3 Homo sapiens 93-96 16000588-4 2005 Furthermore, trastuzumab-mediated ADCC against transforming growth factor-beta-producing SCC was enhanced by the treatment with SB-431542, which is a selective inhibitor of the phosphorylation induced by transforming growth factor-beta. 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide 128-137 serpin family B member 3 Homo sapiens 89-92 15902720-8 2005 Comparison of A1 sequence with the sequence of BP indicated the presence of only three amino acid changes in the carboxyl terminal, two of them were found in the reactive site loop (RSL) of SCCA1. rsl 182-185 serpin family B member 3 Homo sapiens 190-195 15687239-5 2005 Major risk factors for the development of SCC were long duration of chronic GVHD therapy (P < .001); use of azathioprine, particularly when combined with cyclosporine and steroids (P < .001); and severe chronic GVHD (P = .004). Cyclosporine 157-169 serpin family B member 3 Homo sapiens 42-45 15687239-5 2005 Major risk factors for the development of SCC were long duration of chronic GVHD therapy (P < .001); use of azathioprine, particularly when combined with cyclosporine and steroids (P < .001); and severe chronic GVHD (P = .004). Steroids 174-182 serpin family B member 3 Homo sapiens 42-45 15687239-7 2005 Additional analyses determined that prolonged immunosuppressive therapy and azathioprine use were also significant risk factors for SCC of the skin and of the oral mucosa. Azathioprine 76-88 serpin family B member 3 Homo sapiens 132-135 15829803-16 2005 CONCLUSIONS: Topical 0.002% MMC showed a favorable outcome as an adjunctive and alternative treatment of CCIN and SCC with regression of primary and recurrent tumors. Mitomycin 28-31 serpin family B member 3 Homo sapiens 114-117 16852081-0 2005 A critical evaluation of different QM/MM frontier treatments with SCC-DFTB as the QM method. dftb 70-74 serpin family B member 3 Homo sapiens 66-69 16852081-1 2005 The performance of different link atom based frontier treatments in QM/MM simulations was evaluated critically with SCC-DFTB as the QM method. dftb 120-124 serpin family B member 3 Homo sapiens 116-119 16852081-3 2005 The schemes tested include all options available in the program CHARMM for SCC-DFTB/MM simulation, which treat electrostatic interactions due to the MM atoms close to the QM/MM boundary in different ways. dftb 79-83 serpin family B member 3 Homo sapiens 75-78 15829803-1 2005 PURPOSE: To demonstrate the efficacy of topical 0.002% mitomycin C (MMC) as an adjunctive and alternative treatment in primary and recurrent conjunctival-corneal intraepithelial neoplasia (CCIN) and squamous cell carcinoma (SCC). Mitomycin 55-66 serpin family B member 3 Homo sapiens 224-227 15829803-1 2005 PURPOSE: To demonstrate the efficacy of topical 0.002% mitomycin C (MMC) as an adjunctive and alternative treatment in primary and recurrent conjunctival-corneal intraepithelial neoplasia (CCIN) and squamous cell carcinoma (SCC). Mitomycin 68-71 serpin family B member 3 Homo sapiens 224-227 15722648-1 2005 The aim of this study is to clarify the effects of cevimeline on various components in human saliva, such as immunoglobulin A (IgA), lysozyme, alpha-amylase and squamous cell carcinoma (SCC) antigen. cevimeline 51-61 serpin family B member 3 Homo sapiens 186-189 15308173-1 2004 Having demonstrated BPA-BNCT induced control of experimental squamous cell carcinomas (SCC) of the hamster cheek pouch mucosa with no damage to normal tissue we explored the feasibility and safety of treating spontaneous head and neck tumors, with particular focus on SCC, of terminal feline patients with low dose BPA-BNCT employing the thermal beam of the RA-1 Reactor within a preclinical context. bpa-bnct 20-28 serpin family B member 3 Homo sapiens 87-90 15824162-4 2005 A population-based case control study in Southeastern Arizona tested the hypothesis that lower levels of arachidonic acid in RBC membranes were associated with decreased risk of skin squamous cell carcinoma (SCC; n = 335 SCC cases and 321 controls). Arachidonic Acid 105-121 serpin family B member 3 Homo sapiens 208-211 15824162-4 2005 A population-based case control study in Southeastern Arizona tested the hypothesis that lower levels of arachidonic acid in RBC membranes were associated with decreased risk of skin squamous cell carcinoma (SCC; n = 335 SCC cases and 321 controls). Arachidonic Acid 105-121 serpin family B member 3 Homo sapiens 221-224 15824162-8 2005 Increased levels of arachidonic acid in RBC membranes were associated with increased risk of SCC [odds ratio (OR), 1.08 per mg/100 mL change; 95% confidence interval (95% CI), 1.02-1.15] and this association remained when controls with actinic keratosis precursor lesions were excluded. Arachidonic Acid 20-36 serpin family B member 3 Homo sapiens 93-96 15824162-9 2005 SCC risk was highest among the upper quartile of arachidonic acid (OR, 2.38; 95% CI, 1.37-4.12). Arachidonic Acid 49-65 serpin family B member 3 Homo sapiens 0-3 15824162-10 2005 In contrast, increasing proportions of palmitic acid (OR, 0.94; 95% CI, 0.89-1.00) and palmitoleicacid (OR, 0.49; 95% CI, 0.30-0.81) were associated with reduced SCC risk. Palmitic Acid 39-52 serpin family B member 3 Homo sapiens 162-165 15824162-10 2005 In contrast, increasing proportions of palmitic acid (OR, 0.94; 95% CI, 0.89-1.00) and palmitoleicacid (OR, 0.49; 95% CI, 0.30-0.81) were associated with reduced SCC risk. palmitoleic acid 87-102 serpin family B member 3 Homo sapiens 162-165 15756430-5 2005 We assessed the effects of PPAR-gamma ligands on the growth of SCC cells by adding 15-deoxy prostaglandin J2 (15d-PGJ2), or troglitazone to six human esophageal SCC cell lines (TE-1, TE-2, TE-3, TE-5, TE-8, and TE-9). 15-deoxyprostaglandin J2 110-118 serpin family B member 3 Homo sapiens 63-66 15772596-9 2005 Interestingly, the staining rate of p53 and mean PCNA LI were significantly increased in AQ chewers with atrophic OLP (100%, 36.7% +/- 9.0%, respectively), which were similar to those in ED and SCC (all P > .05). aq 89-91 serpin family B member 3 Homo sapiens 194-197 15709146-1 2005 When squamous cell carcinoma (SCC) involves the palatine tonsils, they are generally enlarged and demonstrate intermediate to high signal intensity on T2-weighted MR images and enhance after gadolinium administration. Gadolinium 191-201 serpin family B member 3 Homo sapiens 30-33 15815853-6 2005 The final diagnosis of primary SCC of the liver was confirmed by the clinical pathological features and negative in situ hybridization of Epstein-Barr ribonucleic acids (EBERs). epstein-barr ribonucleic acids 138-168 serpin family B member 3 Homo sapiens 31-34 15308173-2 2004 The biodistribution studies showed that, in all three cases evaluated, BPA delivered absolute boron values to tumor in the range that proved therapeutically useful in the experimental model of SCC. bisphenol A 71-74 serpin family B member 3 Homo sapiens 193-196 15586634-9 2004 Namely, it was revealed that change of 201Tl uptake after preoperative radiotherapy correlated with tumor angiogenesis of oral cavity SCC. Thallium-201 39-44 serpin family B member 3 Homo sapiens 134-137 25048336-4 2004 METHODS: ALA in cream form (20%) was topically applied on biopsy-proven Bowen"s disease or SCC of the skin. Aminolevulinic Acid 9-12 serpin family B member 3 Homo sapiens 91-94 15289857-6 2004 We herein evaluate the cytotoxic effects of heavy carbon-ion beams combined with p53 gene transfer on human esophageal SCC. Carbon 50-56 serpin family B member 3 Homo sapiens 119-122 15381547-6 2004 RESULTS: The cumulative immunosuppressive drug dose 3 years after transplantation (calculated by a weighted linear combination of azathioprine, cyclosporine, and corticosteroid cumulative doses [WLC]) was independently associated with an increased risk of developing SCC but not BCC. Azathioprine 130-142 serpin family B member 3 Homo sapiens 267-270 15289857-11 2004 These data suggest that heavy carbon-ion beam irradiation combined with Ad.p53 may be a potentially effective therapeutic strategy for locally advanced esophageal SCC. Carbon 30-36 serpin family B member 3 Homo sapiens 163-166 15298946-9 2004 However, serum lutein, zeaxanthin, and beta-cryptoxanthin were positively related to SCC risk; risk ratios for subjects in the highest versus lowest tertiles of these micronutrients were 1.63 [95% confidence interval (95% CI) 0.88-3.01; P for trend = 0.01], 2.40 (95% CI 1.30-4.42; P for trend = 0.01), and 2.15 (95% CI 1.21-3.83; P for trend = 0.09), respectively. Beta-Cryptoxanthin 39-57 serpin family B member 3 Homo sapiens 85-88 15298946-10 2004 CONCLUSION: Additional research is needed on the relationship of carotenoids to SCC risk in the general population and in subsets of the population who are at increased risk. Carotenoids 65-76 serpin family B member 3 Homo sapiens 80-83 15194221-2 2004 We recently reported that 15d-PGJ2 inhibits cell growth and induces apoptosis in human oral squamous cell carcinoma (SCC) partly independent of PPARgamma activation. 15-deoxy-delta(12,14)-prostaglandin J2 26-34 serpin family B member 3 Homo sapiens 117-120 15172643-7 2004 In addition, the specific inhibitor of FAS activity cerulenin was able to significantly reduce the proliferation of oral SCC cells. Cerulenin 52-61 serpin family B member 3 Homo sapiens 121-124 15194221-4 2004 15d-PGJ2, but not other PPARgamma ligands, abrogated EGFR protein expression in oral SCC cells. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 serpin family B member 3 Homo sapiens 85-88 15194221-7 2004 These findings provide evidence for EGFR downregulation in oral SCC cells through a novel anticancer effect of 15d-PGJ2 that is attributed to the reactive cyclopentenone ring system. 15-deoxy-delta(12,14)-prostaglandin J2 111-119 serpin family B member 3 Homo sapiens 64-67 15194221-7 2004 These findings provide evidence for EGFR downregulation in oral SCC cells through a novel anticancer effect of 15d-PGJ2 that is attributed to the reactive cyclopentenone ring system. cyclopentenone 155-169 serpin family B member 3 Homo sapiens 64-67 15137039-6 2004 The standardized integrals of the lipid, choline and creatine regions of the spectra were significantly higher in SCC than in normal or CIN tissue. Choline 41-48 serpin family B member 3 Homo sapiens 114-117 15094779-5 2004 Adenoviral delivery of the anti-MMP-13 ribozyme to cutaneous metastatic SCC cells in culture resulted in potent and specific inhibition of the production of proMMP-13 and markedly suppressed invasion of SCC cells through Matrigel. prommp-13 157-166 serpin family B member 3 Homo sapiens 72-75 15503395-4 2004 We also applied 5-ALA ointment with glycolic acid to patients suffering from squamous cell carcinoma (SCC). 5-amino levulinic acid 16-21 serpin family B member 3 Homo sapiens 102-105 15503395-4 2004 We also applied 5-ALA ointment with glycolic acid to patients suffering from squamous cell carcinoma (SCC). glycolic acid 36-49 serpin family B member 3 Homo sapiens 102-105 15503395-8 2004 In 12 patients with single lesions of SCC type subjected to 5-ALA-GA-PDT, we observed 100% regression of tumors following single or repeated two-three times PDT. 5-ala-ga 60-68 serpin family B member 3 Homo sapiens 38-41 15151617-7 2004 CONCLUSIONS: This study provides evidence that COX-2 is upregulated in the majority of cases of squamous dysplasia and SCC of esophagus, and that NS-398 can inhibit growth and induce apoptosis via activating caspase-3 activity in vitro. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 146-152 serpin family B member 3 Homo sapiens 119-122 15137039-6 2004 The standardized integrals of the lipid, choline and creatine regions of the spectra were significantly higher in SCC than in normal or CIN tissue. Creatine 53-61 serpin family B member 3 Homo sapiens 114-117 15137039-8 2004 The acyl fatty acid side-chain length was longer or less unsaturated in SCC than in normal tissue. acyl fatty acid 4-19 serpin family B member 3 Homo sapiens 72-75 15006618-5 2004 When cultured oral SCC cells were incubated with BPA or BSH for 2 h and then exposed to thermal neutrons, the proportion of survival cells that were capable of forming cell colonies decreased exponentially, depending on (10)B concentration. 4-boronophenylalanine 49-52 serpin family B member 3 Homo sapiens 19-22 15006618-5 2004 When cultured oral SCC cells were incubated with BPA or BSH for 2 h and then exposed to thermal neutrons, the proportion of survival cells that were capable of forming cell colonies decreased exponentially, depending on (10)B concentration. mercaptoundecahydrododecaborate 56-59 serpin family B member 3 Homo sapiens 19-22 15006618-8 2004 These results indicate that BPA is more selectively incorporated into human oral SCC as compared with normal oral tissues, and that both extra- and intra-cellular BPA contribute to the cell-killing effect of BNCT. 4-boronophenylalanine 28-31 serpin family B member 3 Homo sapiens 81-84 15006618-9 2004 BPA may be a useful boron carrier for BNCT in the treatment of advanced oral SCC. 4-boronophenylalanine 0-3 serpin family B member 3 Homo sapiens 77-80 15137039-9 2004 Normal tissue from patients with SCC showed significantly higher triglycerides than normal tissue from patients with benign uterine disease but significantly lower triglycerides than SCC tissue. Triglycerides 65-78 serpin family B member 3 Homo sapiens 33-36 15006618-9 2004 BPA may be a useful boron carrier for BNCT in the treatment of advanced oral SCC. Boron 20-25 serpin family B member 3 Homo sapiens 77-80 15137039-9 2004 Normal tissue from patients with SCC showed significantly higher triglycerides than normal tissue from patients with benign uterine disease but significantly lower triglycerides than SCC tissue. Triglycerides 164-177 serpin family B member 3 Homo sapiens 33-36 14719071-0 2004 Cisplatin activates survival signals in UM-SCC-23 squamous cell carcinoma and these signal pathways are amplified in cisplatin-resistant squamous cell carcinoma. Cisplatin 0-9 serpin family B member 3 Homo sapiens 43-46 14747063-1 2004 The aim of this study was to analyze the iodine-unstained region expanding around oral squamous cell carcinoma (SCC) by quantification of telomerase activity. Iodine 41-47 serpin family B member 3 Homo sapiens 112-115 14747063-6 2004 Thirty-three primary cases of oral SCC which have iodine-unstained region around lesions were investigated. Iodine 50-56 serpin family B member 3 Homo sapiens 35-38 14747063-11 2004 Vital staining with iodine is useful for identifying epithelial dysplasia around SCC. Iodine 20-26 serpin family B member 3 Homo sapiens 81-84 14706300-3 2004 We report a case of synchronous oral squamous cell carcinoma (SCC) and gastric adenocarcinoma which was found as an incidental finding during placement of a Percutaneous Endoscopic Gastrostomy (PEG) before resection of the oral tumour. Polyethylene Glycols 194-197 serpin family B member 3 Homo sapiens 62-65 15025965-0 2004 [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]. Histidine 32-41 serpin family B member 3 Homo sapiens 100-129 14719071-5 2004 Cisplatin induced activation of Ras and its downstream effector kinases, Raf/MEK/ERK in UM-SCC-23 human squamous cell carcinoma, suggesting that this anticancer drug activates survival signal pathway in addition to apoptosis signals. Cisplatin 0-9 serpin family B member 3 Homo sapiens 91-94 14719071-6 2004 In cisplatin-resistant UM-SCC-23 in culture, which we have established, the protein levels of Ras, Raf-1 and MEK were drastically elevated compared to parent UM-SCC-23, and ERK and Akt signals were constitutively activated. Cisplatin 3-12 serpin family B member 3 Homo sapiens 26-29 14719071-6 2004 In cisplatin-resistant UM-SCC-23 in culture, which we have established, the protein levels of Ras, Raf-1 and MEK were drastically elevated compared to parent UM-SCC-23, and ERK and Akt signals were constitutively activated. Cisplatin 3-12 serpin family B member 3 Homo sapiens 161-164 14719071-7 2004 U0126, an inhibitor for MEK and LY294002, an inhibitor for phosphatidylinositol 3-kinase (PI3K), sensitized resistant UM-SCC-23 to cisplatin-induced cell death. U 0126 0-5 serpin family B member 3 Homo sapiens 121-124 14719071-7 2004 U0126, an inhibitor for MEK and LY294002, an inhibitor for phosphatidylinositol 3-kinase (PI3K), sensitized resistant UM-SCC-23 to cisplatin-induced cell death. Cisplatin 131-140 serpin family B member 3 Homo sapiens 121-124 14719071-8 2004 These results indicate that Raf/MEK/ERK and PI3K/Akt signal cascades may play a considerable role in cisplatin resistance in SCC. Cisplatin 101-110 serpin family B member 3 Homo sapiens 125-128 14719071-1 2004 cis-Diaminodichloroplatinum (II) (cisplatin) is one of the most effective anticancer drugs and is widely used for the treatment of squamous cell carcinoma (SCC). cis-diaminodichloroplatinum 0-27 serpin family B member 3 Homo sapiens 156-159 14719071-1 2004 cis-Diaminodichloroplatinum (II) (cisplatin) is one of the most effective anticancer drugs and is widely used for the treatment of squamous cell carcinoma (SCC). Cisplatin 34-43 serpin family B member 3 Homo sapiens 156-159 16211988-7 2004 A significant difference in SCC change at 48 hours after the angiography was found (-0.07 mg/dl NAC, 0.09 mg/dl placebo, P = 0.04). Acetylcysteine 96-99 serpin family B member 3 Homo sapiens 28-31 15620040-8 2004 RESULTS AND CONCLUSIONS: The study allowed to establish a strong positive correlation between urine arsenic concentration, blood cadmium concentration and some serum neoplastic markers (CEA, SCC-Ag, PSA). Arsenic 100-107 serpin family B member 3 Homo sapiens 191-194 15844633-1 2004 The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC). Arginine 4-12 serpin family B member 3 Homo sapiens 243-246 16211988-10 2004 CONCLUSIONS: In patients with mild renal impairment patients undergoing angiographic procedures, HPOD of NAC were more effective than placebo in preventing SCC change 48 hours. Acetylcysteine 105-108 serpin family B member 3 Homo sapiens 156-159 14641346-1 2003 BACKGROUND: 5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen"s disease, and keratoacanthoma. Fluorouracil 12-26 serpin family B member 3 Homo sapiens 131-134 14641346-1 2003 BACKGROUND: 5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen"s disease, and keratoacanthoma. Fluorouracil 28-32 serpin family B member 3 Homo sapiens 131-134 14641346-2 2003 OBJECTIVE: We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC. Fluorouracil 56-60 serpin family B member 3 Homo sapiens 107-110 14641346-3 2003 METHODS: A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.8 to 2.4 mL. Fluorouracil 139-143 serpin family B member 3 Homo sapiens 24-27 14594225-11 2003 After 3 mo, total free fatty acids (FFA) contents were significantly higher in the highest SCC cheeses. Fatty Acids, Nonesterified 18-34 serpin family B member 3 Homo sapiens 91-94 14512910-1 2003 BACKGROUND: Small open studies of patients at high risk for squamous cell carcinoma (SCC) of the skin suggest that oral retinoid use reduces the risk of these tumors. Retinoids 120-128 serpin family B member 3 Homo sapiens 85-88 14512910-10 2003 After adjusting for other factors associated with SCC risk, the incidence of SCC was significantly decreased during years of substantial retinoid use (incidence rate ratio = 0.79; 95% confidence interval = 0.65, 0.95). Retinoids 137-145 serpin family B member 3 Homo sapiens 50-53 14512910-10 2003 After adjusting for other factors associated with SCC risk, the incidence of SCC was significantly decreased during years of substantial retinoid use (incidence rate ratio = 0.79; 95% confidence interval = 0.65, 0.95). Retinoids 137-145 serpin family B member 3 Homo sapiens 77-80 14512910-12 2003 CONCLUSION: In patients with psoriasis treated with psoralen-UVA, systemic retinoid use reduced SCC risk but did not significantly alter basal cell carcinoma incidence. Retinoids 75-83 serpin family B member 3 Homo sapiens 96-99 14599856-12 2003 CONCLUSIONS: Frozen section is reliable in the evaluation of CKC specimens with microinvasive SCC: this may afford a simplified surgical approach in certain cases. CKC 61-64 serpin family B member 3 Homo sapiens 94-97 12928897-9 2003 Given that excessive chromosomal losses may confer a disadvantage for tumor growth or a benefit for a metaplastic transformation, these results suggest that the multidirectional differentiation of a SCC precursor is stimulated by extensive and divergent LOHs acquired at the initial or early stages, and a precursor burdened with excessive LOH either remains in CIS or expands as a SA component. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 382-384 serpin family B member 3 Homo sapiens 199-202 14594225-11 2003 After 3 mo, total free fatty acids (FFA) contents were significantly higher in the highest SCC cheeses. Fatty Acids, Nonesterified 36-39 serpin family B member 3 Homo sapiens 91-94 12962369-0 2003 Second-line chemotherapy with bleomycin, methotrexate, and vinorelbine (BMV) for patients with squamous cell carcinoma of the head, neck and esophagus (SCC-HN&E) pretreated with a cisplatin-containing regimen: a phase II study. Vinorelbine 59-70 serpin family B member 3 Homo sapiens 152-155 12768231-3 2003 Thus, patients with end-stage alcohol-induced cirrhosis could be at risk of esophageal SCC following orthotopic liver transplantation (OLT). Alcohols 30-37 serpin family B member 3 Homo sapiens 87-90 12768231-12 2003 Thus, esophageal SCC may develop rapidly in patients undergoing transplantation for alcohol-related cirrhosis with a history of tobacco abuse before liver transplantation, which warrants careful post-transplant screening of these patients. Alcohols 84-91 serpin family B member 3 Homo sapiens 17-20 12928120-7 2003 Baseline AFB score was correlated to outcome, i.e. the development of squamous-cell cancer (SCC) in each individual. afb 9-12 serpin family B member 3 Homo sapiens 92-95 12928120-12 2003 The average AFB score for the group of individuals which developed SCC was significantly different (P<0.001) from the remaining individuals who did not acquire SCC (2.64+/-1.1 vs. 0.6+/-0.7 S.D.). afb 12-15 serpin family B member 3 Homo sapiens 67-70 12928120-13 2003 The number of suspicious lesions at baseline AFB is a good predictor for the development of SCC in the individuals at risk in our study population. afb 45-48 serpin family B member 3 Homo sapiens 92-95 12962369-0 2003 Second-line chemotherapy with bleomycin, methotrexate, and vinorelbine (BMV) for patients with squamous cell carcinoma of the head, neck and esophagus (SCC-HN&E) pretreated with a cisplatin-containing regimen: a phase II study. 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine 72-75 serpin family B member 3 Homo sapiens 152-155 12874860-4 2003 Furthermore, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of tissue extracts showed an abundant 40 kDa band of cleaved SCC antigen-1 in tumor tissue compared to normal tissue. polyacrylamide 36-50 serpin family B member 3 Homo sapiens 152-155 12874860-4 2003 Furthermore, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of tissue extracts showed an abundant 40 kDa band of cleaved SCC antigen-1 in tumor tissue compared to normal tissue. Sodium Dodecyl Sulfate 13-35 serpin family B member 3 Homo sapiens 152-155 12940509-6 2003 Expression of squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, was the highest in the bronchial epithelial cells stimulated by IL-4 and IL-13 and was augmented in the asthmatic cDNA library. Cysteine 71-79 serpin family B member 3 Homo sapiens 14-47 12940509-6 2003 Expression of squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, was the highest in the bronchial epithelial cells stimulated by IL-4 and IL-13 and was augmented in the asthmatic cDNA library. Cysteine 71-79 serpin family B member 3 Homo sapiens 49-54 12874860-4 2003 Furthermore, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of tissue extracts showed an abundant 40 kDa band of cleaved SCC antigen-1 in tumor tissue compared to normal tissue. Sodium Dodecyl Sulfate 72-75 serpin family B member 3 Homo sapiens 152-155 12579497-5 2003 RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08). Aspartic Acid 66-69 serpin family B member 3 Homo sapiens 132-135 12628849-7 2003 Among the TP53 amplified samples, the rate of Arg homozygosity in penile SCC was 61% compared with 68% in BL (non-significant (NS)). Arginine 46-49 serpin family B member 3 Homo sapiens 73-76 12509969-12 2003 These findings suggest that high levels of ATP7B expression in oral SCC are associated with unfavorable clinical outcome in patients with oral SCCs treated with cisplatin-based chemotherapy. Cisplatin 161-170 serpin family B member 3 Homo sapiens 68-71 12579497-5 2003 RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08). Asparagine 46-49 serpin family B member 3 Homo sapiens 132-135 12579497-5 2003 RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08). Asparagine 70-73 serpin family B member 3 Homo sapiens 132-135 12579497-5 2003 RESULTS: Individuals carrying at least one 312Asn variant allele (Asp/Asn and Asn/Asn genotypes) were at an increased risk for lung SCC as compared with those with the Asp/Asp genotype (OR 1.80; 95% CI: 1.10-2.93; adjusted for age, sex and smoking), but this increased risk was not observed among patients with adenocarcinoma of the lung (adjusted OR: 1.07; 95% CI: 0.55-2.08). Asparagine 70-73 serpin family B member 3 Homo sapiens 132-135 12530056-1 2002 The vinorelbine sensitivity of eight recently established head and neck squamous cell carcinoma (SCC) cell lines was tested using the 96-well plate clonogenic assay. Vinorelbine 4-15 serpin family B member 3 Homo sapiens 97-100 12613858-4 2003 The reference DMSCC from MB staining was a reliable method in ewe milk, though more specific stainings such as MGG and PMG slightly improve the residual standard deviation for repeated SCC. Methylene Blue 25-27 serpin family B member 3 Homo sapiens 16-19 12570053-1 2002 Carboplatin (CBDCA) has been widely used for the treatment of oral squamous cell carcinoma (SCC). Carboplatin 0-11 serpin family B member 3 Homo sapiens 92-95 12570053-1 2002 Carboplatin (CBDCA) has been widely used for the treatment of oral squamous cell carcinoma (SCC). Carboplatin 13-18 serpin family B member 3 Homo sapiens 92-95 12570053-3 2002 Morpholino Bcl-xL antisense oligonucleotides (oligos) were employed to down-regulate Bcl-xL in CBDCA-resistant (MIT8, MIT16) as well as CBDCA-sensitive (MIT7) SCC cell lines. Oligonucleotides 28-44 serpin family B member 3 Homo sapiens 159-162 12570053-3 2002 Morpholino Bcl-xL antisense oligonucleotides (oligos) were employed to down-regulate Bcl-xL in CBDCA-resistant (MIT8, MIT16) as well as CBDCA-sensitive (MIT7) SCC cell lines. Oligonucleotides 46-52 serpin family B member 3 Homo sapiens 159-162 12509968-4 2003 Protoporphyrin and coproporphyrin were identified as the fluorescent substance in the SCC samples, and the elution patterns on HPLC revealed some porphyrin compounds as specific to oral cancer. protoporphyrin IX 0-14 serpin family B member 3 Homo sapiens 86-89 12509968-4 2003 Protoporphyrin and coproporphyrin were identified as the fluorescent substance in the SCC samples, and the elution patterns on HPLC revealed some porphyrin compounds as specific to oral cancer. Coproporphyrins 19-33 serpin family B member 3 Homo sapiens 86-89 12557715-0 2003 [A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)]. cddp 135-139 serpin family B member 3 Homo sapiens 72-75 12557715-0 2003 [A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)]. Ethionamide 141-144 serpin family B member 3 Homo sapiens 72-75 12557715-0 2003 [A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)]. Fluorouracil 149-153 serpin family B member 3 Homo sapiens 72-75 12557715-0 2003 [A case of advanced gastric adenocarcinoma with mild elevation of serum SCC that responded remarkably to adjuvant chemotherapy of ADM, CDDP, ETP and 5-FU (ACVF)]. acvf 155-159 serpin family B member 3 Homo sapiens 72-75 12530056-2 2002 The chemosensitivity of these head and neck SCC cell lines to vinorelbine expressed as IC50, corresponding to the drug concentration causing 50% inhibition in clonogenic survival, varied between 0.6 and 1.0 nM. Vinorelbine 62-73 serpin family B member 3 Homo sapiens 44-47 12530056-7 2002 The morphological changes induced by 3 nM and 5 nM vinorelbine to the UT-SCC-33 cell line were analysed with time-lapse video microscopy. Vinorelbine 51-62 serpin family B member 3 Homo sapiens 73-76 12530056-9 2002 These results indicate that, in vitro, the head and neck SCC is consistently sensitive to vinorelbine, which blocks the cell cycle in G2/M, the most radiosensitive phase. Vinorelbine 90-101 serpin family B member 3 Homo sapiens 57-60 12530056-10 2002 These encouraging results suggest that vinorelbine may potentially be used in conjunction with radiotherapy in the treatment of head and neck SCC. Vinorelbine 39-50 serpin family B member 3 Homo sapiens 142-145 12384802-7 2002 RESULTS: The univariate analysis showed a significant risk reduction with increased intake of beta-carotene, vitamin C, vitamin E, and folic acid for both AC and for SCC. beta Carotene 94-107 serpin family B member 3 Homo sapiens 166-169 12423433-9 2002 The number of squamous cell carcinomas (SCC) observed in patients while on acitretin was significantly lower than that in the drug-free period (P = 0.002). Acitretin 75-84 serpin family B member 3 Homo sapiens 40-43 12384802-7 2002 RESULTS: The univariate analysis showed a significant risk reduction with increased intake of beta-carotene, vitamin C, vitamin E, and folic acid for both AC and for SCC. Vitamin E 120-129 serpin family B member 3 Homo sapiens 166-169 12384802-7 2002 RESULTS: The univariate analysis showed a significant risk reduction with increased intake of beta-carotene, vitamin C, vitamin E, and folic acid for both AC and for SCC. Ascorbic Acid 109-118 serpin family B member 3 Homo sapiens 166-169 12384802-7 2002 RESULTS: The univariate analysis showed a significant risk reduction with increased intake of beta-carotene, vitamin C, vitamin E, and folic acid for both AC and for SCC. Folic Acid 135-145 serpin family B member 3 Homo sapiens 166-169 12384802-8 2002 The results of logistic regression analysis were compatible with the known risk factors for SCC (alcohol and tobacco) and for AC (obesity, tobacco, and alcohol) and showed a significant risk reduction with an intake of vitamin E greater than 13 mg/day (RR=0.13, 95% CI=0.1-0.5, P=0.0004) and vitamin C greater than 100 mg/day (RR=0.33, 95% CI=0.11-0.92, P=0.034) for patients with SCC and similar results for patients with AC. Vitamin E 219-228 serpin family B member 3 Homo sapiens 92-95 12384802-8 2002 The results of logistic regression analysis were compatible with the known risk factors for SCC (alcohol and tobacco) and for AC (obesity, tobacco, and alcohol) and showed a significant risk reduction with an intake of vitamin E greater than 13 mg/day (RR=0.13, 95% CI=0.1-0.5, P=0.0004) and vitamin C greater than 100 mg/day (RR=0.33, 95% CI=0.11-0.92, P=0.034) for patients with SCC and similar results for patients with AC. Vitamin E 219-228 serpin family B member 3 Homo sapiens 381-384 12208893-6 2002 RESULTS: The majority of the parental SCC cells underwent apoptosis after a 12-hour exposure to 100 micro M capsaicin or 10 micro M resiniferatoxin. Capsaicin 108-117 serpin family B member 3 Homo sapiens 38-41 12421571-3 2002 Squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, showed the highest expression by IL-4 and IL-13, and particularly, SCCA1 was significantly increased in the asthmatic cDNA library. Cysteine 57-65 serpin family B member 3 Homo sapiens 0-33 12421571-3 2002 Squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, showed the highest expression by IL-4 and IL-13, and particularly, SCCA1 was significantly increased in the asthmatic cDNA library. Cysteine 57-65 serpin family B member 3 Homo sapiens 35-40 12421571-3 2002 Squamous cell carcinoma antigen-1 (SCCA1) and SCCA2, the cysteine and serine protease inhibitors, respectively, showed the highest expression by IL-4 and IL-13, and particularly, SCCA1 was significantly increased in the asthmatic cDNA library. Cysteine 57-65 serpin family B member 3 Homo sapiens 179-184 12175386-18 2002 Squamous cell carcinoma (SCC) in situ, e.g. erythroplasia of Queyrat and Bowen"s disease, cannot be excluded clinically; their apparent clinical benignity may lead to lengthy periods of misdiagnosis and biopsy is required to confirm the diagnosis. queyrat 61-68 serpin family B member 3 Homo sapiens 25-28 12208893-6 2002 RESULTS: The majority of the parental SCC cells underwent apoptosis after a 12-hour exposure to 100 micro M capsaicin or 10 micro M resiniferatoxin. resiniferatoxin 132-147 serpin family B member 3 Homo sapiens 38-41 12208893-11 2002 CONCLUSIONS: Vanilloid-induced apoptosis in the parental SCC cells appears to involve the inhibition of mitochondrial respiration. Capsaicin 13-22 serpin family B member 3 Homo sapiens 57-60 12208893-12 2002 The apoptogenic effects promoted by vanilloid treatment in parental SCC cells, as well as the antiproliferative effects observed in their respiration-deficient clones, suggest that vanilloids may be useful for preventing or treating skin cancers or other hyperproliferative skin disorders. Capsaicin 36-45 serpin family B member 3 Homo sapiens 68-71 12208893-12 2002 The apoptogenic effects promoted by vanilloid treatment in parental SCC cells, as well as the antiproliferative effects observed in their respiration-deficient clones, suggest that vanilloids may be useful for preventing or treating skin cancers or other hyperproliferative skin disorders. vanilloids 181-191 serpin family B member 3 Homo sapiens 68-71 12174873-9 2002 Treatment of SCC cells with CBP2/Hsp47 antisense phosphorothioate oligonucleotides modulated the production of collagen XVIII but not its expression. Phosphorothioate Oligonucleotides 49-82 serpin family B member 3 Homo sapiens 13-16 12215278-9 2002 CONCLUSIONS: ALA-PDT is an effective, non-traumatic treatment for patients with BCC, SCC, Bowen and Paget diseases. Alanine 13-16 serpin family B member 3 Homo sapiens 85-88 12168960-2 2002 Vitamin A derivatives, including 13-cis retinoic acid (13-CRA), have been used to treat DOL and to reduce the risk of subsequent SCC. Vitamin A 0-9 serpin family B member 3 Homo sapiens 129-132 12168960-2 2002 Vitamin A derivatives, including 13-cis retinoic acid (13-CRA), have been used to treat DOL and to reduce the risk of subsequent SCC. Isotretinoin 33-53 serpin family B member 3 Homo sapiens 129-132 11740339-4 2001 This is consistent with a reduced detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAHs) from cigarette smoke that are more important for the development of SCC than for AC. Polycyclic Aromatic Hydrocarbons 65-97 serpin family B member 3 Homo sapiens 173-176 11994981-3 2002 During the fludarabine treatment, the patient developed a local SCC relapse and metastases in the neck. fludarabine 11-22 serpin family B member 3 Homo sapiens 64-67 11994981-5 2002 Nevertheless, the SCC metastasized aggressively and the patient died 3 months after the start of fludarabine treatment, primarily due to respiratory failure. fludarabine 97-108 serpin family B member 3 Homo sapiens 18-21 11874760-1 2002 PURPOSE: To evaluate the efficacy of topical mitomycin-C (MMC) for treatment of postoperative residual conjunctival squamous cell carcinoma (SCC). Mitomycin 45-56 serpin family B member 3 Homo sapiens 141-144 11874760-1 2002 PURPOSE: To evaluate the efficacy of topical mitomycin-C (MMC) for treatment of postoperative residual conjunctival squamous cell carcinoma (SCC). Mitomycin 58-61 serpin family B member 3 Homo sapiens 141-144 11874760-13 2002 CONCLUSIONS: Application of topical MMC is an efficient treatment for residual conjunctival SCC. Mitomycin 36-39 serpin family B member 3 Homo sapiens 92-95 11905536-6 2002 Matumura"s plot predicts an average covalency of 8.8 and 7.7% for the manganese-ligand bond in SCC and SCB lattices respectively. Manganese 70-79 serpin family B member 3 Homo sapiens 95-98 11756239-1 2002 It has been demonstrated previously that the exposure to 7,12-dimethyl[a]benzanthracene (DMBA) and UVB radiation leads to the development of epidermal cysts, squamous cell carcinomas (SCC), melanocytic hyperplasia and melanoma in human foreskins from newborns grafted to immunodeficient mice. 7,12-dimethyl[a]benzanthracene 57-87 serpin family B member 3 Homo sapiens 184-187 11756239-1 2002 It has been demonstrated previously that the exposure to 7,12-dimethyl[a]benzanthracene (DMBA) and UVB radiation leads to the development of epidermal cysts, squamous cell carcinomas (SCC), melanocytic hyperplasia and melanoma in human foreskins from newborns grafted to immunodeficient mice. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 89-93 serpin family B member 3 Homo sapiens 184-187 11956030-2 2002 Retinoids and interferon, in combination with cytotoxic compounds, have been shown to be active in squamous cell carcinoma (SCC). Retinoids 0-9 serpin family B member 3 Homo sapiens 124-127 12080015-2 2002 In the current study, we investigated whether Cd also disrupts progesterone synthesis via P450 cholesterol side-chain cleavage (P450(scc)) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD), enzymes that play important roles in placental steroidogenesis. Cadmium 46-48 serpin family B member 3 Homo sapiens 128-137 12080015-5 2002 However, P450(scc) and 3beta-HSD mRNA transcript levels declined in a dose-dependent manner (P <0.05) in trophoblasts cocultured with 5, 10, or 20 microM CdCl(2). cdcl 157-161 serpin family B member 3 Homo sapiens 9-32 12080015-6 2002 P450(scc) activity was similarly inhibited (P < 0.05) by CdCl(2) treatment, although 3beta-HSD activity was not significantly affected. Cadmium Chloride 60-67 serpin family B member 3 Homo sapiens 0-9 12080015-9 2002 Collectively, results suggest that P450(scc) enzyme is another site at which Cd interferes with placental progesterone production. Cadmium 77-79 serpin family B member 3 Homo sapiens 35-44 12080015-9 2002 Collectively, results suggest that P450(scc) enzyme is another site at which Cd interferes with placental progesterone production. Progesterone 106-118 serpin family B member 3 Homo sapiens 35-44 12232471-1 2002 In this study, our aim was to investigate the prognostic features of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). Thymidine 73-82 serpin family B member 3 Homo sapiens 142-145 11992855-1 2002 PURPOSE: To evaluate the efficacy of topical mitomycin C for extensive recurrent conjunctival and corneal squamous cell carcinoma (SCC). Mitomycin 45-56 serpin family B member 3 Homo sapiens 131-134 11992855-5 2002 The patients received topical mitomycin C 0.04% one drop four times daily in the eye with SCC. Mitomycin 30-41 serpin family B member 3 Homo sapiens 90-93 11799309-6 2001 RESULTS: The known risk factors, alcohol and tobacco for SCC as well as alcohol and a high body mass index for AC, were confirmed in this study. Alcohols 33-40 serpin family B member 3 Homo sapiens 57-60 11740339-4 2001 This is consistent with a reduced detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAHs) from cigarette smoke that are more important for the development of SCC than for AC. Polycyclic Aromatic Hydrocarbons 99-103 serpin family B member 3 Homo sapiens 173-176 11878102-1 2001 A prospective study was done to test the efficacy of 5-fluorouracil (topical and systemic) in multiple and unresectable histologically proven facial squamous cell carcinomas (SCC) secondary to XP. Fluorouracil 53-67 serpin family B member 3 Homo sapiens 175-178 11746830-5 2001 The vitamin A metabolite retinoic acid (RA) has been used as a chemotherapeutic drug in the treatment of SCC. Vitamin A 4-13 serpin family B member 3 Homo sapiens 105-108 11746830-5 2001 The vitamin A metabolite retinoic acid (RA) has been used as a chemotherapeutic drug in the treatment of SCC. Tretinoin 25-38 serpin family B member 3 Homo sapiens 105-108 11746830-5 2001 The vitamin A metabolite retinoic acid (RA) has been used as a chemotherapeutic drug in the treatment of SCC. Tretinoin 40-42 serpin family B member 3 Homo sapiens 105-108 11746830-7 2001 However, we previously found that treatment of SCC lines with inhibitory doses of RA sensitized cells to the proliferative effects of EGF. Tretinoin 82-84 serpin family B member 3 Homo sapiens 47-50 11878102-11 2001 Despite a dissociation between a good cosmetic result and a relatively superficial effect, topical 5-FU represents a useful therapeutic option in multiple unresectable facial SCC in patients with XP. Fluorouracil 99-103 serpin family B member 3 Homo sapiens 175-178 11669536-2 2001 After heat treatment at 70 degrees C for 2 h, the tumor tissue extract showed a single main protein band of 45 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) which reacted with a monoclonal antibody specific for SCC antigen. Sodium Dodecyl Sulfate 177-180 serpin family B member 3 Homo sapiens 241-244 11521231-4 2001 5-mc immunostaining scores of DNA of SCC (0.61 +/- 0.42) and associated hyperplastic lesions (0.82 +/- 0.27) was significantly lower than those of DNA of histologically normal bronchial epithelial cells (0.99 +/- 0.52) and hyperplastic lesions (1.2 +/- 0.22) of noncancer specimens. 5-Methylcytosine 0-4 serpin family B member 3 Homo sapiens 37-40 11697847-3 2001 Between 1994 and 1997, three patients with SCC of the esophagus were treated at Besancon University Hospital and this represented 1.85% of all esophageal malignancies diagnosed during this period: one patient had a limited tumor and underwent initial surgical resection, then chemotherapy with cisplatine and etoposide, and radiotherapy for recurrences. transplatin 294-304 serpin family B member 3 Homo sapiens 43-46 11697847-3 2001 Between 1994 and 1997, three patients with SCC of the esophagus were treated at Besancon University Hospital and this represented 1.85% of all esophageal malignancies diagnosed during this period: one patient had a limited tumor and underwent initial surgical resection, then chemotherapy with cisplatine and etoposide, and radiotherapy for recurrences. Etoposide 309-318 serpin family B member 3 Homo sapiens 43-46 11530278-1 2001 The essay examines the evidence upon which the presently accepted version of the mechanism of the cytochrome P450(scc)-catalyzed-cleavage of the sidechain of cholesterol is based. Cholesterol 158-169 serpin family B member 3 Homo sapiens 114-117 11547572-4 2001 A previous mutation analysis revealed that SCC in PUVA-treated patients often carried mutated p53 genes and that many of the mutations had the UV fingerprint (i.e. C-->T or CC-->TT transitions at dipyrimidine sites). dipyrimidine 202-214 serpin family B member 3 Homo sapiens 43-46 11323100-6 2001 The esophageal SCC in either smokers or alcohol users was 4.67-5.83 times more likely to express p53 protein, while the likelihood of p53 expression in patients who use both tobacco and alcohol was more than 14.0 times. Alcohols 40-47 serpin family B member 3 Homo sapiens 15-18 11500624-13 2001 CONCLUSIONS: Early SCC of the tongue and floor of the mouth in Vizcaya affects mainly male smokers and drinkers of alcohol under the age of 60 years. Alcohols 115-122 serpin family B member 3 Homo sapiens 19-22 11442593-7 2001 RESULTS: We treated these five patients with a combination of a local immune therapy, imiquimod cream, and a topical chemotherapeutic agent, 5% 5-fluorouracil (5-FU), with clearing of the areas of SCC in situ. Fluorouracil 160-164 serpin family B member 3 Homo sapiens 197-200 11442593-9 2001 In addition, there is evidence that cytokines induced by imiquimod may improve the therapeutic efficacy of topical 5% 5-FU in the treatment of SCC in situ. Fluorouracil 118-122 serpin family B member 3 Homo sapiens 143-146 11441301-4 2001 The main risk factors for the development of SCC as well as for AC are heavy smoking and alcohol. Alcohols 89-96 serpin family B member 3 Homo sapiens 45-48 11441301-8 2001 The preoperative risk factors of patients with SCC are caused by tobacco and alcohol. Alcohols 77-84 serpin family B member 3 Homo sapiens 47-50 11257063-6 2001 Among individuals with toenail arsenic concentrations above the 97th percentile, the adjusted odds ratios were 2.07 (95% confidence interval (CI): 0.92, 4.66) for SCC and 1.44 (95% CI: 0.74, 2.81) for BCC, compared with those with concentrations at or below the median. Arsenic 31-38 serpin family B member 3 Homo sapiens 163-166 11237771-3 2001 A similar effect was observed with 13-cis retinoic acid (RA), which has been used in chemoprevention of SCC. Isotretinoin 35-55 serpin family B member 3 Homo sapiens 104-107 11237771-3 2001 A similar effect was observed with 13-cis retinoic acid (RA), which has been used in chemoprevention of SCC. Tretinoin 57-59 serpin family B member 3 Homo sapiens 104-107 11350913-3 2001 In this study, we examined the effects of the novel proteasome inhibitor PS-341 on activation of NF-kappa B and cell survival, growth, and angiogenesis in murine and human SCC cell lines. Bortezomib 73-79 serpin family B member 3 Homo sapiens 172-175 11350913-4 2001 PS-341 inhibited activation of NF-kappa B DNA binding and functional reporter activity at concentrations between 10(-8) and 10(-7) M. Cytotoxicity was observed at 10(-7) M in four murine and two human SCC lines, and followed early cleavage of poly(ADP-ribose) polymerase, a marker of caspase-mediated apoptosis. Bortezomib 0-6 serpin family B member 3 Homo sapiens 201-204 11350913-5 2001 In vivo, PS-341 inhibited growth of murine and human SCC in mice at doses of 1--2 mg/kg given three times weekly, and dose-limiting toxicity was encountered at 2 mg/kg. Bortezomib 9-15 serpin family B member 3 Homo sapiens 53-56 11350913-7 2001 PS-341 inhibited expression of the proangiogenic cytokines growth-regulated oncogene-alpha and vascular endothelial growth factor by SCC in the range at which PS-341 inhibits NF-kappa B. Bortezomib 0-6 serpin family B member 3 Homo sapiens 133-136 11350913-7 2001 PS-341 inhibited expression of the proangiogenic cytokines growth-regulated oncogene-alpha and vascular endothelial growth factor by SCC in the range at which PS-341 inhibits NF-kappa B. Bortezomib 159-165 serpin family B member 3 Homo sapiens 133-136 11350913-8 2001 We conclude that PS-341 inhibits activation of NF-kappa B pathway components related to cell survival, tumor growth, and angiogenesis in SCC. Bortezomib 17-23 serpin family B member 3 Homo sapiens 137-140 11182054-7 2001 Quantitative RT-PCR ELISA digoxigenin-labeling assay demonstrated that SCCA1 mRNA expression in squamous cell carcinoma cell lines was respectively 2.8 times and 42 times that in keratinocyte and non-squamous cell carcinoma cell lines. Digoxigenin 26-37 serpin family B member 3 Homo sapiens 71-76 11207687-3 2001 OBJECTIVE: To determine if combination therapy using topical imiquimod cream 5% and the oral cyclooxygenase (COX) inhibitor are useful in the therapy of squamous cell carcinoma in situ (SCC in situ)/Bowen"s disease in patients with long-standing CLL. Imiquimod 61-70 serpin family B member 3 Homo sapiens 186-189 11272732-3 2001 We observed that both in basal cell carcinomas (BCC) and squamous cell carcinomas (SCC) the endogenous fluorescence due to tryptophan residues was more intense in tumor than in normal tissue, probably due to epidermal thickening and/or hyperproliferation. Tryptophan 123-133 serpin family B member 3 Homo sapiens 83-86 11098077-5 2000 A strong reciprocal relationship between Rb and p16(INK4A) expression was observed in oral SCC, and all these SCC cases have at least one of the alterations in the Rb pathway. Rubidium 41-43 serpin family B member 3 Homo sapiens 91-94 11150108-9 2001 MAIN OUTCOME MEASURE: Risk for the development of cervical SCC by IgG antibodies to 10 different C trachomatis serotypes, adjusted for antibodies to HPV types 16, 18, and 33 and for serum cotinine levels. Cotinine 188-196 serpin family B member 3 Homo sapiens 59-62 11129014-4 2000 Accordingly, preclinical studies to evaluate the use of valrubicin, a contact-safe, mechanistically novel antitumor agent, combined with low-dose radiation for the therapy of SCC have been conducted. valrubicin 56-66 serpin family B member 3 Homo sapiens 175-178 11129014-11 2000 This effect appears to correlate with the ability of valrubicin, a cytoplasmic-localizing drug, to inhibit protein kinase C. Therapeutic use of valrubicin against SCC could provide for reduced radiation doses with consequent improved efficacy and reduction in host toxicity. valrubicin 53-63 serpin family B member 3 Homo sapiens 163-166 11129014-11 2000 This effect appears to correlate with the ability of valrubicin, a cytoplasmic-localizing drug, to inhibit protein kinase C. Therapeutic use of valrubicin against SCC could provide for reduced radiation doses with consequent improved efficacy and reduction in host toxicity. valrubicin 144-154 serpin family B member 3 Homo sapiens 163-166 11098077-5 2000 A strong reciprocal relationship between Rb and p16(INK4A) expression was observed in oral SCC, and all these SCC cases have at least one of the alterations in the Rb pathway. Rubidium 41-43 serpin family B member 3 Homo sapiens 110-113 11042692-1 2000 Type I Interferon (IFN) and all-trans retinoic acid (RA) inhibit cell proliferation of squamous carcinoma cell lines (SCC). Tretinoin 38-51 serpin family B member 3 Homo sapiens 118-121 11131565-5 2000 The results suggested that both radiolabeled methyl incorporation assay and immunostaining for 5-mc can be used to demonstrate hypomethylation of DNA in SCC tissues compared to matched uninvolved tissues. 5-mc 95-99 serpin family B member 3 Homo sapiens 153-156 11042692-1 2000 Type I Interferon (IFN) and all-trans retinoic acid (RA) inhibit cell proliferation of squamous carcinoma cell lines (SCC). Tretinoin 53-55 serpin family B member 3 Homo sapiens 118-121 11042692-3 2000 In combination treatment RA potentiates IFN-beta effect in SCC ME-180 but not in SiHa cell line, partially resistant to RA antiproliferative action. Tretinoin 25-27 serpin family B member 3 Homo sapiens 59-62 11075866-4 2000 The main outcome measure is the odds ratio (OR) of incidence rates of invasive cervical squamous cell carcinoma (SCC) among those seropositive for HPV16 and/or C. trachomatis and/or with increased levels of cotinine in serum compared to those negative for all the three exposures. Cotinine 207-215 serpin family B member 3 Homo sapiens 113-116 11075866-9 2000 Each of the three exposures was associated with an increased risk of SCC (OR = 5.4 for HPV16, 3.4 for C. trachomatis and 1.8 for cotinine). Cotinine 129-137 serpin family B member 3 Homo sapiens 69-72 15014794-11 2000 CONCLUSION: Apoptosis was induced by cisplatin in Tca8113 cells, and it may be an important mechanism of SCC killed by cisplatin. Cisplatin 37-46 serpin family B member 3 Homo sapiens 105-108 15014794-11 2000 CONCLUSION: Apoptosis was induced by cisplatin in Tca8113 cells, and it may be an important mechanism of SCC killed by cisplatin. Cisplatin 119-128 serpin family B member 3 Homo sapiens 105-108 10931059-5 2000 Alcohol and tobacco consumption was higher in patients with an SCC (P < 0.01 and P < 0.05 respectively). Alcohols 0-7 serpin family B member 3 Homo sapiens 63-66 10931059-6 2000 The preoperative forced expiratory volume, arterial partial pressure of oxygen and the aminopyrine breath test showed more severely compromised pulmonary and hepatic function in patients with an SCC (P < 0.05 for all variables). Oxygen 72-78 serpin family B member 3 Homo sapiens 195-198 10931059-6 2000 The preoperative forced expiratory volume, arterial partial pressure of oxygen and the aminopyrine breath test showed more severely compromised pulmonary and hepatic function in patients with an SCC (P < 0.05 for all variables). Aminopyrine 87-98 serpin family B member 3 Homo sapiens 195-198 10811994-3 2000 In the present study, we examined the effect of the novel non-peptide alphav integrin antagonist SM256 on growth of SCC line PAM LY8 in BALB/c SCID mice, and determined whether SM256 has direct inhibitory effects on growth of murine endothelial and PAM LY8 SCC cells in vitro. SM 256 97-102 serpin family B member 3 Homo sapiens 116-119 10875237-0 2000 Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3",5"-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells. Calcium 0-7 serpin family B member 3 Homo sapiens 142-151 10875237-0 2000 Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3",5"-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells. cyclic 3",5"-adenosine monophosphate 77-113 serpin family B member 3 Homo sapiens 142-151 10875237-4 2000 In the presence of extracellular Ca2+, FSH and 8 Br-cAMP stimulated expression of the transfected P450(scc) promoter-reporter fusion construct by 5.6 +/- 1.1 and 3.6 +/- 0.67-fold, respectively over Ca2+-containing unstimulated control (P < or = 0.04, n = 5-6 experiments). Cyclic AMP 52-56 serpin family B member 3 Homo sapiens 103-106 10875237-6 2000 FSH and 8 Br-cAMP also significantly elevated endogenous P450(scc) transcript levels as measured by homologous solution-hybridization RNase protection assay; i.e. by 3.1 +/- 0.49 and 2.9 +/- 0.45-fold, respectively (P < or = 0.001). Cyclic AMP 13-17 serpin family B member 3 Homo sapiens 57-65 10875237-7 2000 In Ca2+-free/EGTA-supplemented medium, basal luciferase reporter-gene activity and endogenous P450(scc) messenger RNA accumulation in granulosa cells declined to 34 +/- 12% and 78 +/- 12%, respectively, of corresponding values in control (unstimulated Ca2+-containing) cultures. Egtazic Acid 13-17 serpin family B member 3 Homo sapiens 94-103 10875237-8 2000 Extracellular Ca2+ deprivation inhibited the stimulatory effect of FSH (and 8 Br-cAMP) on P450(scc) promoter-luciferase reporter expression to 58 +/- 30% (and 58 +/- 23%), and restrained endogenous P450(scc) message accumulation to 86 +/- 15% (and 96 +/- 18%) of the value in Ca2+-containing control. Cyclic AMP 81-85 serpin family B member 3 Homo sapiens 95-98 10875237-8 2000 Extracellular Ca2+ deprivation inhibited the stimulatory effect of FSH (and 8 Br-cAMP) on P450(scc) promoter-luciferase reporter expression to 58 +/- 30% (and 58 +/- 23%), and restrained endogenous P450(scc) message accumulation to 86 +/- 15% (and 96 +/- 18%) of the value in Ca2+-containing control. Cyclic AMP 81-85 serpin family B member 3 Homo sapiens 90-99 10875237-11 2000 Antagonism of cellular uptake of Ca2+ and other divalent cations via administration of cobalt chloride (100 microM) inhibited FSH and 8 Br-cAMP"s stimulation of endogenous (but not exogenous promoter-driven) P450(scc) gene expression. cobaltous chloride 87-102 serpin family B member 3 Homo sapiens 208-217 10875237-13 2000 In summary, uptake of extracellular Ca2+ by porcine granulosa cells significantly potentiates transactivation of the endogenously expressed and exogenously transfected P450(scc) gene by FSH and 8 Br-cAMP. Cyclic AMP 199-203 serpin family B member 3 Homo sapiens 168-177 10875237-14 2000 The agonistic impact of Ca2+ on P450(scc) promoter activity is requisite downstream of FSH-induced cAMP second-messenger signaling. Cyclic AMP 99-103 serpin family B member 3 Homo sapiens 32-41 10852705-12 2000 Moreover, these data established the importance of a Pro residue in the P3" position for efficient inhibition of catS by both wild-type SCCA1 and mutated SCCA2. Proline 53-56 serpin family B member 3 Homo sapiens 136-141 10929767-2 2000 We examined archival paraffin blocks of samples of squamous cell carcinoma (SCC) in chronic venous leg ulcers previously taken from 23 patients and of chronic noncancerous venous leg ulcers from 35 patients for the presence of human papillomavirus (HPV) DNA. Paraffin 21-29 serpin family B member 3 Homo sapiens 76-79 10850407-2 2000 The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon. Arginine 4-12 serpin family B member 3 Homo sapiens 188-191 10850407-2 2000 The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon. Proline 117-124 serpin family B member 3 Homo sapiens 188-191 10850407-2 2000 The arginine allele at codon 72 of p53 was found to be more susceptible to degradation by HPV E6 protein than is the proline allele in vivo, thus resulting in a high frequency of cervical SCC in individuals homozygous for arginine at the codon. Arginine 222-230 serpin family B member 3 Homo sapiens 188-191 10811994-9 2000 These results demonstrate the activity and feasibility of use of alphav antagonists such as SM256 for therapy of SCC. SM 256 92-97 serpin family B member 3 Homo sapiens 113-116 10815782-1 2000 This prospective study was designed to examine the relationship between serial serum nitric oxide (NO) levels and pain during the emergency department (ED) treatment of acute vasoocclusive sickle cell crisis (SCC). Nitric Oxide 85-97 serpin family B member 3 Homo sapiens 209-212 10820352-2 2000 The purpose of this study is to examine the usefulness of transvaginal color Doppler ultrasound (TV-CDU) in differentiating malignant (SCC) from benign cystic teratoma of the ovary. tv-cdu 97-103 serpin family B member 3 Homo sapiens 135-138 10820352-12 2000 CONCLUSIONS: Evaluating the presence or absence of intratumoral blood flow, together with blood flow resistance, in tumor vessels using TV-CDU thus may be more useful to differentiate malignant (SCC) from benign cystic teratomas of the ovary than by measuring serum SCC levels. tv-cdu 136-142 serpin family B member 3 Homo sapiens 195-198 10783309-7 2000 We have performed similar analyses in an in vitro model of SCC in which four squamous tumor cell lines and UPR cells were sorted according to increasing resistance to external cytotoxic stimuli, i.e. starving conditions, treatment with the retinoid N-(4-hydroxyphenyl)retinamide and cytolytic activity of effector lymphokine-activated killer cells. Retinoids 240-248 serpin family B member 3 Homo sapiens 59-62 10793329-3 2000 We report here that genetic risk for oral SCC was associated with another isoleucine-valine (Ile-Val) polymorphism, which resulted in an Ile-Val amino acid replacement in the heme-binding region of CYP1A1, and combined genotyping of CYP1A1 and GSTM1 genes in relation to the cumulative cigarette-smoking dose. isoleucine-valine 74-91 serpin family B member 3 Homo sapiens 42-45 10885602-2 2000 59 oesophageal squamous cell carcinoma (SCC) patients received cisplatin 30 mg/m2/week treatment of two to five cycles, followed by oesophagectomy. Cisplatin 63-72 serpin family B member 3 Homo sapiens 40-43 10793329-3 2000 We report here that genetic risk for oral SCC was associated with another isoleucine-valine (Ile-Val) polymorphism, which resulted in an Ile-Val amino acid replacement in the heme-binding region of CYP1A1, and combined genotyping of CYP1A1 and GSTM1 genes in relation to the cumulative cigarette-smoking dose. isoleucylvaline 93-100 serpin family B member 3 Homo sapiens 42-45 10793329-3 2000 We report here that genetic risk for oral SCC was associated with another isoleucine-valine (Ile-Val) polymorphism, which resulted in an Ile-Val amino acid replacement in the heme-binding region of CYP1A1, and combined genotyping of CYP1A1 and GSTM1 genes in relation to the cumulative cigarette-smoking dose. isoleucylvaline 137-144 serpin family B member 3 Homo sapiens 42-45 10793329-3 2000 We report here that genetic risk for oral SCC was associated with another isoleucine-valine (Ile-Val) polymorphism, which resulted in an Ile-Val amino acid replacement in the heme-binding region of CYP1A1, and combined genotyping of CYP1A1 and GSTM1 genes in relation to the cumulative cigarette-smoking dose. Heme 175-179 serpin family B member 3 Homo sapiens 42-45 10728604-10 2000 There were non-significant negative associations between EV-HPV and NMSC (OR 0.77, 95% CI 0.34-1.8) and BCC (OR 0.58, 95% CI 0.23-1.5) but a non-significant positive association with SCC (OR 2.00, 95% CI 0.50-8.0). ev-hpv 57-63 serpin family B member 3 Homo sapiens 183-186 10653592-10 2000 In contrast to previous studies, these data indicated that the expression of SCCA1 and SCCA2 was not restricted to the squamous epithelium and that these serpins may coordinately regulate cysteine and serine proteinase activity in both normal and transformed tissues. Cysteine 188-196 serpin family B member 3 Homo sapiens 77-82 10732775-4 2000 In this report, we demonstrated that apoptosis induced by 7-ethyl-10-hydroxycamptothecin, tumour necrosis factor-alpha (TNF-alpha) or interleukin (IL)-2-activated natural killer (NK) cells was significantly inhibited in tumour cells transduced with the SCC Ag-1 cDNA, as compared to control cells in vitro. Irinotecan 58-88 serpin family B member 3 Homo sapiens 253-256 10732775-5 2000 Also, inhibition of the SCC Ag-1 expression in tumour cells by transfection of antisense SCC Ag-1 cDNA was accompanied by significantly increased sensitivity of these cells to apoptosis induced by etoposide or TNF-alpha. Etoposide 197-206 serpin family B member 3 Homo sapiens 24-27 10732775-5 2000 Also, inhibition of the SCC Ag-1 expression in tumour cells by transfection of antisense SCC Ag-1 cDNA was accompanied by significantly increased sensitivity of these cells to apoptosis induced by etoposide or TNF-alpha. Etoposide 197-206 serpin family B member 3 Homo sapiens 89-92 10754498-8 2000 Interestingly, heavy drinking had a significant positive correlation with the p53 mutation, but heavy smoking did not, suggesting that prolonged exposure to alcohol is more related to p53 mutation in oropharyngeal SCC than to tobacco consumption. Alcohols 157-164 serpin family B member 3 Homo sapiens 214-217 10719037-9 2000 Through a rigorous statistical test, the PUVA-induced p53 mutation spectrum appears to differ significantly (P < 0.0002) from that observed in SCC in PUVA-treated patients. puva 153-157 serpin family B member 3 Homo sapiens 146-149 10719037-11 2000 This result may suggest that PUVA therapy can be a risk factor for the development of SCC in psoriasis patients through a mechanism not involving the induction of p53 mutations. puva 29-33 serpin family B member 3 Homo sapiens 86-89 10677093-1 2000 CONTEXT: Although basic research provides plausible mechanisms for benefits of beta carotene supplementation on nonmelanoma skin cancer (NMSC) primarily consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), observational studies are inconsistent. beta Carotene 79-92 serpin family B member 3 Homo sapiens 223-226 10890025-4 2000 Our data show a consistent tendency for a lower risk of SCC with higher intakes of n-3 fatty acids [p (for trend) = 0.055]. Fatty Acids, Omega-3 83-98 serpin family B member 3 Homo sapiens 56-59 10890025-7 2000 More studies are clearly needed to elucidate the function of dietary fatty acids so that recommendations can be made to alter the human diet for cancer prevention, particularly in light of the increasing incidence of SCC of the skin. Fatty Acids 69-80 serpin family B member 3 Homo sapiens 217-220 10890025-2 2000 In the present study, we investigated the association between dietary n-3 and n-6 fatty acid intake and risk of squamous cell carcinoma of the skin (SCC). Fatty Acids, Omega-6 78-92 serpin family B member 3 Homo sapiens 149-152 10519399-6 1999 AS cyclin D1 significantly inhibited cell proliferation by both [3H]thymidine incorporation in six SCC cell lines (P = 0.01-0.001) and the conversion of tetrazolium salt to formazan in four SCC cell lines (P = 0.01-0.004). Thymidine 68-77 serpin family B member 3 Homo sapiens 99-102 10697607-5 1999 In addition, we found a statistically significant correlation between PET positive cases and high MPS-H serum levels in SCC-H&N patients with recurrent disease. Adenosine Monophosphate 126-129 serpin family B member 3 Homo sapiens 120-123 10382961-6 1999 Despite surgery and adjuvant chemotherapy with 5-fluorouracil (5-FU) the patient died 1 year after the diagnosis of SCC. Fluorouracil 63-67 serpin family B member 3 Homo sapiens 116-119 10446454-3 1999 To investigate the role of bax gene expression in modulating cisplatin (CDDP)-induced apoptosis in vitro, an established CDDP-resistant human head and neck SCC (IMC-3 cell line) was transfected with bax gene-bearing mammalian expression vector. Cisplatin 121-125 serpin family B member 3 Homo sapiens 156-159 10446454-6 1999 Furthermore, combination therapy with bax gene transfer and subcutaneous administration of CDDP at 3-day intervals markedly inhibited the growth of mouse SCC. Cisplatin 91-95 serpin family B member 3 Homo sapiens 154-157 10456842-4 1999 Basally applied histamine produced transient increases in PD and I(scc) with a small decrease in R. The histamine effect was reduced by triprolidine (H(1) receptor antagonist) but was unaffected by H(2) (ranitidine) or H(3) (thioperamide) receptor antagonists. Histamine 16-25 serpin family B member 3 Homo sapiens 67-70 10456842-4 1999 Basally applied histamine produced transient increases in PD and I(scc) with a small decrease in R. The histamine effect was reduced by triprolidine (H(1) receptor antagonist) but was unaffected by H(2) (ranitidine) or H(3) (thioperamide) receptor antagonists. Histamine 104-113 serpin family B member 3 Homo sapiens 67-70 10456842-4 1999 Basally applied histamine produced transient increases in PD and I(scc) with a small decrease in R. The histamine effect was reduced by triprolidine (H(1) receptor antagonist) but was unaffected by H(2) (ranitidine) or H(3) (thioperamide) receptor antagonists. Triprolidine 136-148 serpin family B member 3 Homo sapiens 67-70 10419010-1 1999 Expression of the CYP11A1 (SCC) genes, which encode the enzyme important for the first step of steroid biosynthesis, occurs in the adrenal gland and gonads, and is stimulated by cAMP. Steroids 95-102 serpin family B member 3 Homo sapiens 27-30 10419010-1 1999 Expression of the CYP11A1 (SCC) genes, which encode the enzyme important for the first step of steroid biosynthesis, occurs in the adrenal gland and gonads, and is stimulated by cAMP. Cyclic AMP 178-182 serpin family B member 3 Homo sapiens 27-30 10419010-2 1999 Transfection of serial deletions of the SCC promoter, which drives reporter gene expression, showed that a minimal promoter containing only the TATA box could direct cAMP-dependent transcription. Cyclic AMP 166-170 serpin family B member 3 Homo sapiens 40-43 10419010-5 1999 Additional experiments replacing the TATA sequence of SCC with other TATA sequences suggested that the TATA sequence itself is important for this cAMP-dependent transcription. Cyclic AMP 146-150 serpin family B member 3 Homo sapiens 54-57 10025742-5 1999 After adjustment for age, kidney transplant recipients receiving cyclosporine, azathioprine, and prednisolone had a significantly (2.8 times) higher risk of cutaneous SCC relative to those receiving azathioprine and prednisolone. Cyclosporine 65-77 serpin family B member 3 Homo sapiens 167-170 9935158-6 1999 Thus, CD95L expression in SCC may contribute to tumor-associated immunosuppression, which may be modulated by CDDP and IFNgamma. Cisplatin 110-114 serpin family B member 3 Homo sapiens 26-29 10368636-2 1999 The aim of this study was to detect the protein expression pattern of hMSH2 and hMLH1 in oral squamous cell carcinoma (SCC) by immunohistochemistry in paraffin-embedded tissues. Paraffin 151-159 serpin family B member 3 Homo sapiens 119-122 10435152-7 1999 The most common site of occurrence of SCC was the buccal mucosa (263/703 patients; 37.4%), both overall and in patients who chewed betel quid alone or in combination with cigarette smoking and/or alcohol consumption; the tongue was the most common site among patients without any oral habits (18/48 patients; 37.5%). Alcohols 196-203 serpin family B member 3 Homo sapiens 38-41 10025742-5 1999 After adjustment for age, kidney transplant recipients receiving cyclosporine, azathioprine, and prednisolone had a significantly (2.8 times) higher risk of cutaneous SCC relative to those receiving azathioprine and prednisolone. Azathioprine 79-91 serpin family B member 3 Homo sapiens 167-170 10025742-5 1999 After adjustment for age, kidney transplant recipients receiving cyclosporine, azathioprine, and prednisolone had a significantly (2.8 times) higher risk of cutaneous SCC relative to those receiving azathioprine and prednisolone. Prednisolone 97-109 serpin family B member 3 Homo sapiens 167-170 9989277-5 1999 Most notable was that SCC formed only about one-fourth the retinoid ester as did normal cells. retinoid ester 59-73 serpin family B member 3 Homo sapiens 22-25 9989277-13 1999 Consistent with increased substrate-driven retinoic acid synthesis in SCC, the expression of transglutaminase 1 was suppressed to a greater extent in the SCCs than in NHK, when cells were exposed to equivalent medium concentrations of retinol. Tretinoin 43-56 serpin family B member 3 Homo sapiens 70-73 9989277-6 1999 In parallel with this, unesterified retinol and retinoic acid concentrations in SCC were significantly elevated over those in normal cells. Vitamin A 36-43 serpin family B member 3 Homo sapiens 80-83 9989277-13 1999 Consistent with increased substrate-driven retinoic acid synthesis in SCC, the expression of transglutaminase 1 was suppressed to a greater extent in the SCCs than in NHK, when cells were exposed to equivalent medium concentrations of retinol. Vitamin A 235-242 serpin family B member 3 Homo sapiens 70-73 9989277-6 1999 In parallel with this, unesterified retinol and retinoic acid concentrations in SCC were significantly elevated over those in normal cells. Tretinoin 48-61 serpin family B member 3 Homo sapiens 80-83 9989277-7 1999 This altered pattern of retinoid metabolites in SCC was found to be due to very low lecithin:retinol acyltransferase (LRAT) activity. Retinoids 24-32 serpin family B member 3 Homo sapiens 48-51 9989277-10 1999 Challenging cells with increasing medium retinol concentrations resulted in dose-dependent increases in retinol and retinoic acid within SCC. Vitamin A 41-48 serpin family B member 3 Homo sapiens 137-140 9989277-10 1999 Challenging cells with increasing medium retinol concentrations resulted in dose-dependent increases in retinol and retinoic acid within SCC. Vitamin A 104-111 serpin family B member 3 Homo sapiens 137-140 9989277-10 1999 Challenging cells with increasing medium retinol concentrations resulted in dose-dependent increases in retinol and retinoic acid within SCC. Tretinoin 116-129 serpin family B member 3 Homo sapiens 137-140 10216492-2 1999 In a pilot phase II study, in order to improve the immune function during chemotherapy, we combined to cisplatin (CDDP) and 5-fluorouracil (5-FU) two biological response modifiers, retinyl palmitate (R) and Thymopentin (TP-5) for the treatment of SCC. Fluorouracil 124-138 serpin family B member 3 Homo sapiens 247-250 9887236-1 1998 PURPOSE: Preclinical and clinical data support the study of retinoids and interferon-alpha (IFN-alpha) in advanced squamous cell carcinoma of the uterine cervix (SCC). Retinoids 60-69 serpin family B member 3 Homo sapiens 162-165 10376448-6 1999 The majority of patients with 17OH-A (83.3%) or SCC-A (76.9%) were also found positive for 21OH-A and all three antibody specificities were positively correlated with the presence of ACA. 21oh-a 91-97 serpin family B member 3 Homo sapiens 48-53 10376448-6 1999 The majority of patients with 17OH-A (83.3%) or SCC-A (76.9%) were also found positive for 21OH-A and all three antibody specificities were positively correlated with the presence of ACA. 4-amylcinnamoylanthranilic acid 183-186 serpin family B member 3 Homo sapiens 48-53 9875197-10 1998 CONCLUSION: Although the incidence of SCC reported among groups of PUVA-treated patients followed up for at least 5 years varies greatly, compared with the risk in low-dose patients, long-term high-dose exposure to PUVA was consistently observed to significantly increase the risk of SCC in all studies reviewed. puva 67-71 serpin family B member 3 Homo sapiens 38-41 9875197-10 1998 CONCLUSION: Although the incidence of SCC reported among groups of PUVA-treated patients followed up for at least 5 years varies greatly, compared with the risk in low-dose patients, long-term high-dose exposure to PUVA was consistently observed to significantly increase the risk of SCC in all studies reviewed. puva 67-71 serpin family B member 3 Homo sapiens 284-287 9875197-10 1998 CONCLUSION: Although the incidence of SCC reported among groups of PUVA-treated patients followed up for at least 5 years varies greatly, compared with the risk in low-dose patients, long-term high-dose exposure to PUVA was consistently observed to significantly increase the risk of SCC in all studies reviewed. puva 215-219 serpin family B member 3 Homo sapiens 38-41 9875197-10 1998 CONCLUSION: Although the incidence of SCC reported among groups of PUVA-treated patients followed up for at least 5 years varies greatly, compared with the risk in low-dose patients, long-term high-dose exposure to PUVA was consistently observed to significantly increase the risk of SCC in all studies reviewed. puva 215-219 serpin family B member 3 Homo sapiens 284-287 9930370-1 1998 We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto"s criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. heparan sulfate glycosaminoglycan 322-355 serpin family B member 3 Homo sapiens 97-100 9769345-3 1998 This article summarizes in vitro investigations that have been performed to evaluate 1H MR spectroscopy of SCC of the upper aerodigestive tract. Hydrogen 85-87 serpin family B member 3 Homo sapiens 107-110 9807072-4 1998 BSC is also commonly confused histologically with poorly differentiated SCC (PDSCC). bsc 0-3 serpin family B member 3 Homo sapiens 72-75 9811823-10 1998 Collectively, these data suggested that the sequence and mobility of the RSL of SCCA1 are essential for cysteine proteinase inhibition and that serpins are likely to utilize a common RSL-dependent mechanism to inhibit both serine and cysteine proteinases. rsl 73-76 serpin family B member 3 Homo sapiens 80-85 9930370-1 1998 We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto"s criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. hs-gag 357-363 serpin family B member 3 Homo sapiens 97-100 9930370-1 1998 We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto"s criteria, and the cellular expressions of CD44, E-cadherin (E-cad), heparan sulfate glycosaminoglycan (HS-GAG) and Phaseolus vulgaris leukoagglutinin (L-PHA)-binding oligosaccharides on the carcinomas. Oligosaccharides 420-436 serpin family B member 3 Homo sapiens 97-100 9600820-15 1998 Patients negative for serum squamous cell carcinoma-associated antigen (SCC) responded better to NAC than to SCC-positive cases, and SCC-negative survival was significantly better than SCC-positive survival (P < 0.05). nac 97-100 serpin family B member 3 Homo sapiens 28-70 9879152-1 1998 OBJECTIVE: To evaluate prognostic importance of p53, PCNA and vascularization alteration in patients with locally advanced cervical squamous cell carcinoma (SCC) after combination therapy with 13-cis-retinoic acid (13cRA) and interferon-alpha 2a (IFN-alpha 2a). Isotretinoin 193-213 serpin family B member 3 Homo sapiens 157-160 9681345-1 1998 OBJECTIVE: To investigate the immediate and long-term effects of photodynamic therapy with delta-aminolevulinic acid (ALA-PDT) on superficial basal cell carcinomas (BCC) and superficial squamous cell carcinomas (SCC). Aminolevulinic Acid 91-116 serpin family B member 3 Homo sapiens 212-215 9681345-1 1998 OBJECTIVE: To investigate the immediate and long-term effects of photodynamic therapy with delta-aminolevulinic acid (ALA-PDT) on superficial basal cell carcinomas (BCC) and superficial squamous cell carcinomas (SCC). 1-phenyl-3,3-dimethyltriazene 118-125 serpin family B member 3 Homo sapiens 212-215 9681345-14 1998 CONCLUSIONS: Our study revealed poor long-term cure rates for superficial BCC and SCC treated with topical ALA-PDT and visible light. Alanine 107-110 serpin family B member 3 Homo sapiens 82-85 9738740-3 1998 The objective of the current study was to test intratumor cisplatinum (cis-diaminedichloroplatinum [CDDP]) injections given in conjunction with laser therapy as an experimental approach for improved treatment of squamous cell carcinoma (SCC). Cisplatin 58-69 serpin family B member 3 Homo sapiens 237-240 9738740-3 1998 The objective of the current study was to test intratumor cisplatinum (cis-diaminedichloroplatinum [CDDP]) injections given in conjunction with laser therapy as an experimental approach for improved treatment of squamous cell carcinoma (SCC). Cisplatin 71-98 serpin family B member 3 Homo sapiens 237-240 9600820-15 1998 Patients negative for serum squamous cell carcinoma-associated antigen (SCC) responded better to NAC than to SCC-positive cases, and SCC-negative survival was significantly better than SCC-positive survival (P < 0.05). nac 97-100 serpin family B member 3 Homo sapiens 72-75 9496831-18 1998 For LCNEC, 18% and 4% of the diagnoses were called SCC and AC, respectively. lcnec 4-9 serpin family B member 3 Homo sapiens 51-54 9548757-11 1998 Cleavage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathepsin S complex by sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggested that the serpin interacted with the cysteine proteinase in a manner similar to that observed for typical serpin-serine proteinase interactions. Serine 29-32 serpin family B member 3 Homo sapiens 94-99 9548757-11 1998 Cleavage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathepsin S complex by sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggested that the serpin interacted with the cysteine proteinase in a manner similar to that observed for typical serpin-serine proteinase interactions. Sodium Dodecyl Sulfate 123-145 serpin family B member 3 Homo sapiens 94-99 9548757-11 1998 Cleavage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathepsin S complex by sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggested that the serpin interacted with the cysteine proteinase in a manner similar to that observed for typical serpin-serine proteinase interactions. polyacrylamide 146-160 serpin family B member 3 Homo sapiens 94-99 9548757-11 1998 Cleavage between the Gly and Ser residues of the reactive site loop and detection of a stable SCCA1-cathepsin S complex by sodium dodecyl sulfate-polyacrylamide gel electrophoresis suggested that the serpin interacted with the cysteine proteinase in a manner similar to that observed for typical serpin-serine proteinase interactions. Glycine 21-24 serpin family B member 3 Homo sapiens 94-99 9552033-1 1998 PURPOSE: To assess the activity and toxicity profile of combined taxol (paclitaxel), ifosfamide, and platinum (cisplatin) (TIP) in patients with recurrent or metastatic squamous cell carcinoma (SCC) of the head and neck. Cisplatin 111-120 serpin family B member 3 Homo sapiens 194-197 9520026-2 1998 OBJECTIVE: To assess the safety and efficacy, we conducted an open-label pilot study of 5-FU/epi gel in 25 patients with biopsy-proven SCC lesions on the face, head, neck, trunk, arms, and hands. Fluorouracil 88-92 serpin family B member 3 Homo sapiens 135-138 9520026-8 1998 CONCLUSION: Treatment of superficial SCC with 5-FU/epi injectable gel results in a high rate of histologically confirmed complete tumor responses and may provide a nonsurgical treatment alternative in selected patients. Fluorouracil 46-50 serpin family B member 3 Homo sapiens 37-40 9817979-9 1998 17beta-estradiol and L-triiodothyronine were found to upregulate EGF-R expression, proliferative potential and SCC production in the CaSki cervical carcinoma cells. Estradiol 0-16 serpin family B member 3 Homo sapiens 111-114 9544188-8 1998 In addition, the frequency of UVB-type mutations at dipyrimidine sites (CC-->TT) in the SCC PUVA-treated psoriasis patients was comparable to that in patients with SCC from only solar exposure. dipyrimidine 52-64 serpin family B member 3 Homo sapiens 91-94 9486671-17 1998 Patients with SCC were significantly older at the start of arsenic exposure and had significantly more palmar arsenical keratoses than those without SCC. Arsenic 59-66 serpin family B member 3 Homo sapiens 14-17 9817979-9 1998 17beta-estradiol and L-triiodothyronine were found to upregulate EGF-R expression, proliferative potential and SCC production in the CaSki cervical carcinoma cells. Triiodothyronine 21-39 serpin family B member 3 Homo sapiens 111-114 9428674-3 1997 207, 69-73] demonstrated two conformations (A and B) of cytochrome P-450scc (SCC), the enzyme which initiates steroid biosynthesis by cleaving the side chain of cholesterol. Steroids 110-117 serpin family B member 3 Homo sapiens 77-80 9428674-3 1997 207, 69-73] demonstrated two conformations (A and B) of cytochrome P-450scc (SCC), the enzyme which initiates steroid biosynthesis by cleaving the side chain of cholesterol. Cholesterol 161-172 serpin family B member 3 Homo sapiens 77-80 9367069-10 1997 Therefore, we concluded that daily supplementation with 25,000 IU of retinol was effective in preventing SCC, although it did not prevent BCC. Vitamin A 69-76 serpin family B member 3 Homo sapiens 105-108 9516286-14 1997 79% to 82% of the respondents indicated that tobacco and alcohol were the principal causes of oral SCC, but 34.6% suggested that HIV disease was a risk factor for oral SCC. Alcohols 57-64 serpin family B member 3 Homo sapiens 99-102 9367069-7 1997 Comparing retinol-supplemented subjects with placebo-supplemented subjects showed a hazard ratio for first new SCC of 0.74 (95% confidence interval, 0.56-0.99; P = 0.04). Vitamin A 10-17 serpin family B member 3 Homo sapiens 111-114 9202163-3 1997 An increase in urinary 8-OHdG/creatinine was found in non-small-cell carcinoma (non-SCC) patients during the course of radiotherapy. 8-ohdg 23-29 serpin family B member 3 Homo sapiens 84-87 9294609-1 1997 Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations. 4-Nitroquinoline-1-oxide 51-75 serpin family B member 3 Homo sapiens 129-132 9294609-1 1997 Our previous reports have shown that two thirds of 4-nitroquinoline-1-oxide (4NQO)-induced murine oral squamous cell carcinomas (SCC) have Hras1 mutations. 4-Nitroquinoline-1-oxide 77-81 serpin family B member 3 Homo sapiens 129-132 9331351-3 1997 Cocaine induced focal signal increases in nucleus accumbens/subcallosal cortex (NAc/SCC), caudate, putamen, basal forebrain, thalamus, insula, hippocampus, parahippocampal gyrus, cingulate, lateral prefrontal and temporal cortices, parietal cortex, striate/extrastriate cortices, ventral tegmentum, and pons and produced signal decreases in amygdala, temporal pole, and medial frontal cortex. Cocaine 0-7 serpin family B member 3 Homo sapiens 84-87 9202163-3 1997 An increase in urinary 8-OHdG/creatinine was found in non-small-cell carcinoma (non-SCC) patients during the course of radiotherapy. Creatinine 30-40 serpin family B member 3 Homo sapiens 84-87 9202163-4 1997 SCC patients showed higher levels of urinary 8-OHdG/creatinine than the controls. 8-ohdg 45-51 serpin family B member 3 Homo sapiens 0-3 9202163-4 1997 SCC patients showed higher levels of urinary 8-OHdG/creatinine than the controls. Creatinine 52-62 serpin family B member 3 Homo sapiens 0-3 9202163-5 1997 Furthermore, SCC patients with complete or partial response to the chemotherapy showed a significant decrease in urinary 8-OHdG/creatinine while patients with no change or progressive disease showed an increase. 8-ohdg 121-127 serpin family B member 3 Homo sapiens 13-16 9202163-5 1997 Furthermore, SCC patients with complete or partial response to the chemotherapy showed a significant decrease in urinary 8-OHdG/creatinine while patients with no change or progressive disease showed an increase. Creatinine 128-138 serpin family B member 3 Homo sapiens 13-16 9137431-1 1997 In the current study, paclitaxel sensitivity of eight vulvar squamous cell carcinoma (SCC) cell lines was tested using a 96-well plate clonogenic assay. Paclitaxel 22-32 serpin family B member 3 Homo sapiens 86-89 10994465-2 1997 This is the phenomenon of elevated blood calcium in the absence of bony metastases in patients with certain solid tumours, most commonly squamous cell carcinoma (SCC) of the lung, but also occurring in SCC at other sites including skin, and other cancers including melanoma. Calcium 41-48 serpin family B member 3 Homo sapiens 162-165 10994465-2 1997 This is the phenomenon of elevated blood calcium in the absence of bony metastases in patients with certain solid tumours, most commonly squamous cell carcinoma (SCC) of the lung, but also occurring in SCC at other sites including skin, and other cancers including melanoma. Calcium 41-48 serpin family B member 3 Homo sapiens 202-205 9137431-4 1997 The paclitaxel sensitivity of the eight vulvar SCC cell lines expressed as IC50 varied from 0.6 to 2.9 nM. Paclitaxel 4-14 serpin family B member 3 Homo sapiens 47-50 9137431-6 1997 Paclitaxel sensitivity of vulvar SCC cell lines is of the same magnitude as the paclitaxel sensitivity of endometrial and ovarian carcinoma cell lines tested in our preliminary experiments with the same assay. Paclitaxel 0-10 serpin family B member 3 Homo sapiens 33-36 9137431-9 1997 These results indicate that vulvar SCC is consistently sensitive to paclitaxel in vitro. Paclitaxel 68-78 serpin family B member 3 Homo sapiens 35-38 9022270-2 1996 When an extract was prepared from 0.1 g human skin homogenized with 1 ml of phosphate buffered saline, this method was able to detect SCC antigen in extracts diluted 10(2)-fold. Phosphate-Buffered Saline 76-101 serpin family B member 3 Homo sapiens 134-137 9067656-7 1997 The Eu3+ release assay was then used to measure NK and LAK activities in the peripheral blood of women with cervical SIL or cervical squamous cell carcinoma (SCC). eu3+ 4-8 serpin family B member 3 Homo sapiens 158-161 9008232-3 1997 Four genes not previously described in psoriasis--connexin 26, a gap junction protein; squamous cell carcinoma antigen-1 (SCCA1), a serine protease inhibitor; and mitochondrial NAD subunits 5 and 6--were identified as having very high expression levels in psoriatic skin. NAD 177-180 serpin family B member 3 Homo sapiens 87-120 9210914-6 1997 Fludarabine depresses the T lymphocyte population, cells that play a pivotal role in the regression of the SCC. fludarabine 0-11 serpin family B member 3 Homo sapiens 107-110 9210914-7 1997 We suggest, that the flare-up and exacerbation of the SCC lesions of the patient were triggered by the fludarabine therapy. fludarabine 103-114 serpin family B member 3 Homo sapiens 54-57 8959162-1 1996 OBJECTIVES: 1) To measure nitric oxide (NO) metabolite levels in patients presenting to the ED in acute vaso-occlusive sickle-cell crisis (SCC), and 2) to determine whether a relationship exists between NO metabolite levels and pain. Nitric Oxide 26-38 serpin family B member 3 Homo sapiens 139-142 8881817-10 1996 For SNP, increased delta SCC is at least due in part to chloride secretion, and the response seems to be transduced through enteric nerves and by local prostanoid synthesis. Chlorides 56-64 serpin family B member 3 Homo sapiens 25-28 8943746-6 1996 RESULTS: The incidence of well differentiated SCC of the lung was high in patients from Okinawa compared with moderately and poorly differentiated types, and compared with the incidence of SCC in patients from Niigata. niigata 210-217 serpin family B member 3 Homo sapiens 189-192 8949994-5 1996 We report two patients with recurrent squamous cell carcinoma (SCC) of the cervix who had small-volume progressive metastatic disease, and were treated with a combination of IFN-alpha and 13-cis-retinoic acid. Isotretinoin 188-208 serpin family B member 3 Homo sapiens 63-66 8905873-4 1996 The DF3 antigen was not expressed in NSE (0%), whereas it was expressed in 20 DSE (41%) and in 31 SCC (61%). N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide 4-7 serpin family B member 3 Homo sapiens 98-101 8881817-3 1996 METHODS: Changes in short circuit current (delta SCC) in response to nitric oxide donating compounds were measured in muscle stripped normal human colon mounted in Ussing chambers. Nitric Oxide 69-81 serpin family B member 3 Homo sapiens 49-52 8881817-6 1996 SNAP 10(-4)M also evoked a qualitatively similar delta SCC compared with SNP 10(-4)M. Basolateral SNP evoked a greater delta SCC than apical and this was significantly attenuated by bumetanide 10(-4)M (52.9 +/- 10.1%) and in chloride free media (68.3 +/- 7.3%). Bumetanide 182-192 serpin family B member 3 Homo sapiens 125-128 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Piroxicam 56-65 serpin family B member 3 Homo sapiens 18-21 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Masoprocol 103-126 serpin family B member 3 Homo sapiens 18-21 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Tetrodotoxin 151-163 serpin family B member 3 Homo sapiens 18-21 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Tetrodotoxin 165-168 serpin family B member 3 Homo sapiens 18-21 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Tetrodotoxin 221-224 serpin family B member 3 Homo sapiens 18-21 8881817-8 1996 SNP induced delta SCC was also significantly reduced by piroxicam (mean (SEM)) 10(-5)M (57.9 (11.9)%), nordihydroguaretic acid 10(-4)M (48.0 (12.9)%), tetrodotoxin (TTX 10(-6)M, 52.3 (9.1)%), and practically abolished by TTX and piroxicam together (96.8 (3.3)%). Piroxicam 229-238 serpin family B member 3 Homo sapiens 18-21 8918988-0 1996 Side-chain cleavage of cholesterol esters by human cytochrome P-450(scc). Cholesterol Esters 23-41 serpin family B member 3 Homo sapiens 51-72 8918988-1 1996 In order to define the substrate binding site of human cytochrome P-450(scc) in the vicinity of the 3beta-hydroxyl group of cholesterol, we have tested the ability of the cytochrome to cleave the side chain of a range of cholesterol esters and cholesterol methyl ether. Cholesterol 124-135 serpin family B member 3 Homo sapiens 55-76 8918988-1 1996 In order to define the substrate binding site of human cytochrome P-450(scc) in the vicinity of the 3beta-hydroxyl group of cholesterol, we have tested the ability of the cytochrome to cleave the side chain of a range of cholesterol esters and cholesterol methyl ether. Cholesterol Esters 221-239 serpin family B member 3 Homo sapiens 55-76 8918988-1 1996 In order to define the substrate binding site of human cytochrome P-450(scc) in the vicinity of the 3beta-hydroxyl group of cholesterol, we have tested the ability of the cytochrome to cleave the side chain of a range of cholesterol esters and cholesterol methyl ether. Cholesterol 221-232 serpin family B member 3 Homo sapiens 55-76 8918988-1 1996 In order to define the substrate binding site of human cytochrome P-450(scc) in the vicinity of the 3beta-hydroxyl group of cholesterol, we have tested the ability of the cytochrome to cleave the side chain of a range of cholesterol esters and cholesterol methyl ether. Ether 263-268 serpin family B member 3 Homo sapiens 55-76 8683307-0 1996 Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT. UNLABELLED: The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases. Tyrosine 145-148 serpin family B member 3 Homo sapiens 223-226 8683307-7 1996 CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. Tyrosine 17-20 serpin family B member 3 Homo sapiens 26-29 8882744-2 1995 The somatic cell count (SCC) correlated negatively with milk yield and lactose whilst positively with milk protein and milk fat, except for Pleven F1 ewes which showed these correlations with reversed values. Lactose 71-78 serpin family B member 3 Homo sapiens 24-27 8629424-2 1996 CASE: Repeated cytology via PTCD from a cystically dilated duct in a 56-year-old female with a long clinical history permitted a diagnosis of squamous cell carcinoma (SCC). ptcd 28-32 serpin family B member 3 Homo sapiens 167-170 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 0-10 serpin family B member 3 Homo sapiens 82-85 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 0-10 serpin family B member 3 Homo sapiens 233-236 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 0-10 serpin family B member 3 Homo sapiens 233-236 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 12-17 serpin family B member 3 Homo sapiens 82-85 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 12-17 serpin family B member 3 Homo sapiens 233-236 8601573-1 1996 Paclitaxel (Taxol) is a potent chemotherapeutic drug for squamous-cell carcinoma (SCC) of the head and neck in vitro with microtubule-stabilizing activity that arrests cells in G2-M. To study the mechanism of its cytotoxic effect on SCC in vitro, we exposed five laryngeal SCC cell lines to 10 nM paclitaxel. Paclitaxel 12-17 serpin family B member 3 Homo sapiens 233-236 7498125-1 1995 Squamous cell carcinoma (SCC) antigen was tested, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, for its ability to inhibit the activity of serine proteases, i.e., trypsin, chymotrypsin and elastase. Sodium Dodecyl Sulfate 53-75 serpin family B member 3 Homo sapiens 25-28 7498125-1 1995 Squamous cell carcinoma (SCC) antigen was tested, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, for its ability to inhibit the activity of serine proteases, i.e., trypsin, chymotrypsin and elastase. polyacrylamide gels 76-94 serpin family B member 3 Homo sapiens 25-28 7498125-3 1995 Preincubation of chymotrypsin with recombinant SCC antigen inhibited chymotryptic digestion of gelatin and ovalbumin through the formation of sodium dodecyl sulfate-stable complexes. Sodium Dodecyl Sulfate 142-164 serpin family B member 3 Homo sapiens 47-50 21153183-6 1995 In HPX ewes treated with LH, concentrations of progesterone in sera and luteal mRNA for P450(scc) and 3beta-HSD increased but luteal weights were unaffected. Luteinizing Hormone 25-27 serpin family B member 3 Homo sapiens 88-111 8605102-5 1996 This contrasts with previous work showing a FAL of 32% in SCC and 46% in actinic keratoses. fal 44-47 serpin family B member 3 Homo sapiens 58-61 7602354-15 1995 CONCLUSIONS: Both EDX and MTX are moderately active against SCC. edatrexate 18-21 serpin family B member 3 Homo sapiens 60-63 7602354-15 1995 CONCLUSIONS: Both EDX and MTX are moderately active against SCC. Methotrexate 26-29 serpin family B member 3 Homo sapiens 60-63 7582186-7 1995 These studies suggest that cisplatin may be a key drug for chemotherapy of oesophageal SCC, and etoposide plus cisplatin treatment may be especially recommended in the treatment of gastric SCC. Cisplatin 27-36 serpin family B member 3 Homo sapiens 87-90 8597820-2 1995 We report an unusual case of SCC of the tongue as a second malignancy in a young adult with a history of a stage III clear cell sarcoma of the kidney (CCSK) treated 19 years earlier. ccsk 151-155 serpin family B member 3 Homo sapiens 29-32 7917985-5 1994 The patients with SCC were significantly older at the start of PUVA treatment than those with keratoses alone. puva 63-67 serpin family B member 3 Homo sapiens 18-21 7813942-3 1994 4 men and 4 women (mean age 70, range 49-86) with advanced BCC and/or SCC were treated with cisplatin-based chemotherapy. Cisplatin 92-101 serpin family B member 3 Homo sapiens 70-73 7831583-5 1994 Natural and synthetic retinoids have been found to augment the antiproliferative activity of IFNs in several squamous cell carcinoma (SCC) and breast tumor cell lines. Retinoids 22-31 serpin family B member 3 Homo sapiens 134-137 7699280-1 1994 Silver-binding nucleolar organizing regions (AgNORs) in normal oral buccal mucosa epithelium, oral leukoplakia, and oral squamous cell carcinoma (SCC) were studied. Silver 0-6 serpin family B member 3 Homo sapiens 146-149 7917985-7 1994 These results show that high-dose PUVA treatment in the U.K., even when given alone, can frequently result in the development of SCC. puva 34-38 serpin family B member 3 Homo sapiens 129-132 8138442-2 1994 The cytostatic agent alpha-difluoromethylornithine (DFMO) was investigated for its capacity to slow proliferation kinetics in human squamous cell carcinomas (SCC) of the head and neck (H&N), with the ultimate objective of improving locoregional control in rapidly dividing tumors treated with radiation therapy. Eflornithine 21-50 serpin family B member 3 Homo sapiens 158-161 8137214-4 1994 METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues. Formaldehyde 82-90 serpin family B member 3 Homo sapiens 34-37 8137214-4 1994 METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues. Paraffin 98-106 serpin family B member 3 Homo sapiens 34-37 8194017-5 1994 RESULTS: Squamous cell carcinoma (SCC) developed in more than one fourth of patients exposed to high doses of PUVA. puva 110-114 serpin family B member 3 Homo sapiens 34-37 8194017-7 1994 High-level exposure to methotrexate is a significant independent risk factor for developing SCC (relative risk, 2.1 for high versus low or no exposure; 95% CI, 1.4-2.8). Methotrexate 23-35 serpin family B member 3 Homo sapiens 92-95 8194017-10 1994 CONCLUSIONS: Long term exposure to PUVA and methotrexate significantly increases the risk of SCC in patients with psoriasis. puva 35-39 serpin family B member 3 Homo sapiens 93-96 8194017-10 1994 CONCLUSIONS: Long term exposure to PUVA and methotrexate significantly increases the risk of SCC in patients with psoriasis. Methotrexate 44-56 serpin family B member 3 Homo sapiens 93-96 8138442-5 1994 DFMO effects on in vitro SCC radiosensitivity using clonogenic survival were also studied. Eflornithine 0-4 serpin family B member 3 Homo sapiens 25-28 8138442-6 1994 RESULTS: A noncytotoxic exposure to DFMO (5mM x 72 hours) induced pronounced growth inhibition in all three SCC cell lines (70-90% at 7 days), and induced a 2-3 fold delay in volume doubling time for SCC tumor xenografts when administered orally in the drinking water (1.5%) to athymic mice. Eflornithine 36-40 serpin family B member 3 Homo sapiens 108-111 8138442-2 1994 The cytostatic agent alpha-difluoromethylornithine (DFMO) was investigated for its capacity to slow proliferation kinetics in human squamous cell carcinomas (SCC) of the head and neck (H&N), with the ultimate objective of improving locoregional control in rapidly dividing tumors treated with radiation therapy. Eflornithine 52-56 serpin family B member 3 Homo sapiens 158-161 8138442-7 1994 Kinetic analysis via flow cytometry confirmed that DFMO produced a lengthening of SCC cell cycle times, but did not alter in vitro radiosensitivity. Eflornithine 51-55 serpin family B member 3 Homo sapiens 82-85 8138442-9 1994 CONCLUSION: These data indicate that antiproliferative agents, such as DFMO, are capable of altering human SCC growth kinetics without altering intrinsic radiosensitivity. Eflornithine 71-75 serpin family B member 3 Homo sapiens 107-110 7923565-1 1994 Because of their antiproliferative and differentiation-inducing properties, retinoids have been used clinically as therapeutic and chemopreventive agents against squamous-cell carcinomas (SCC). Retinoids 76-85 serpin family B member 3 Homo sapiens 188-191 7923565-3 1994 Because encapsulation of certain drugs in lipid vesicles (liposomes) has been shown to result in reduced toxic effects, we studied the in vitro interaction of liposome-encapsulated all-trans-retinoic acid (L-ATRA) with a SCC line (MDA 886Ln) and its multicellular tumor spheroid (MTS) model. Tretinoin 181-204 serpin family B member 3 Homo sapiens 221-224 7923565-7 1994 These results suggest that liposomes can serve as an effective carrier system for the delivery of retinoids to SCC. Retinoids 98-107 serpin family B member 3 Homo sapiens 111-114 1616864-6 1992 Our data were used to estimate the implications of a future ozone depletion for the incidence rates of skin cancer: a 10% ozone depletion was found to give rise to a 16-18% increase in the incidence rate of SCC (men and women), a 19% increase in the incidence rate of CMM for men and a 32% increase in the incidence rate of CMM for women. Ozone 60-65 serpin family B member 3 Homo sapiens 207-210 7902777-3 1993 METHODS: SCC antigen was immunohistochemically stained in Grade 3 pT1 TCC of the bladder that had been fixed in formaldehyde solution and embedded in paraffin. Formaldehyde 112-124 serpin family B member 3 Homo sapiens 9-12 7902777-3 1993 METHODS: SCC antigen was immunohistochemically stained in Grade 3 pT1 TCC of the bladder that had been fixed in formaldehyde solution and embedded in paraffin. Paraffin 150-158 serpin family B member 3 Homo sapiens 9-12 8318203-6 1993 Similarly, DFMO administered continuously via the drinking water to athymic mice harboring human SCC xenografts induced a prolongation of in vivo tumor volume doubling. Eflornithine 11-15 serpin family B member 3 Homo sapiens 97-100 8318203-7 1993 CONCLUSIONS: These data indicate that biologic agents, such as DFMO, can alter SCC growth kinetics and may prove useful in designing new therapeutic strategies for rapidly proliferating tumors such as those that occur in the head and neck. Eflornithine 63-67 serpin family B member 3 Homo sapiens 79-82 1306728-5 1992 By contrast, in patients older than 60 years of age, oral SCC was more common in males, occurred more frequently in social classes III and IV and was always seen in association with smoking, alcohol or pan chewing. Alcohols 191-198 serpin family B member 3 Homo sapiens 58-61 1469793-6 1992 Biochemical analysis by thin-layer chromatography (TLC) with resorcinol staining and TLC immunostaining with either M2590 or R24 showed both GM3 and GD3 to be commonly expressed by both the normal and malignant skin tissues, including SCC. gm3 141-144 serpin family B member 3 Homo sapiens 235-238 7688499-1 1993 In Japan the regimen with peplomycin has been mainly used for the treatment of squamous cell carcinoma (SCC). Peplomycin 26-36 serpin family B member 3 Homo sapiens 104-107 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 29-38 serpin family B member 3 Homo sapiens 150-153 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 29-38 serpin family B member 3 Homo sapiens 244-247 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 29-38 serpin family B member 3 Homo sapiens 244-247 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 72-81 serpin family B member 3 Homo sapiens 150-153 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 72-81 serpin family B member 3 Homo sapiens 244-247 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Cisplatin 72-81 serpin family B member 3 Homo sapiens 244-247 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Doxorubicin 86-96 serpin family B member 3 Homo sapiens 150-153 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Doxorubicin 86-96 serpin family B member 3 Homo sapiens 244-247 7688499-2 1993 But recently, a regimen with cisplatin, particularly the combination of cisplatin and adriamycin (CA chemotherapy) has been used for the treatment of SCC, and a better prognosis has resulted Since CA chemotherapy is very effective for not only SCC, but also basal cell carcinoma (BCC), we think it is a prominent neoadjuvant therapy for SCC and BCC. Doxorubicin 86-96 serpin family B member 3 Homo sapiens 244-247 8112724-3 1993 We have tested this hypothesis in subjects with multiple myeloma (MM) and squamous cell carcinoma (SCC) treated with pamidronate. Pamidronate 117-128 serpin family B member 3 Homo sapiens 99-102 8112724-6 1993 Calcitriol levels were significantly higher and magnesium levels slightly lower in the SCC group than those in the MM group. Calcitriol 0-10 serpin family B member 3 Homo sapiens 87-90 8112724-6 1993 Calcitriol levels were significantly higher and magnesium levels slightly lower in the SCC group than those in the MM group. Magnesium 48-57 serpin family B member 3 Homo sapiens 87-90 1732383-8 1992 This reduction was probably due to a direct effect of hydrocortisone on PLP synthesis because the expression of PLP mRNA was also reduced in the presence of hydrocortisone when tested in SCC-4 cells. Hydrocortisone 54-68 serpin family B member 3 Homo sapiens 187-190 17795216-4 1992 The spectrum of ScC(82) has features similar to those found earlier for LaC(82) and YC(82), suggesting that it can also be described as a +3 metal cation within a -3 fullerene radical anion. Metals 141-146 serpin family B member 3 Homo sapiens 16-19 17795216-4 1992 The spectrum of ScC(82) has features similar to those found earlier for LaC(82) and YC(82), suggesting that it can also be described as a +3 metal cation within a -3 fullerene radical anion. Fullerenes 166-175 serpin family B member 3 Homo sapiens 16-19 1732383-8 1992 This reduction was probably due to a direct effect of hydrocortisone on PLP synthesis because the expression of PLP mRNA was also reduced in the presence of hydrocortisone when tested in SCC-4 cells. Hydrocortisone 157-171 serpin family B member 3 Homo sapiens 187-190 1733553-0 1992 Beta-carotene and/or vitamin E as modulators of alkylating agents in SCC-25 human squamous carcinoma cells. beta Carotene 0-13 serpin family B member 3 Homo sapiens 69-72 1733553-8 1992 Exposure to vitamin E or to a combination of beta-carotene and vitamin E increased the glutathione-S-transferase activity in SCC-25 cells by 40%-45% over the control value. Vitamin E 63-72 serpin family B member 3 Homo sapiens 125-128 1733553-9 1992 Treatment with beta-carotene, vitamin E, or canthaxanthin reduced the incorporation of [3H]-thymidine into SCC-25 cells but not that into normal human keratinocytes. beta Carotene 15-28 serpin family B member 3 Homo sapiens 107-110 1733553-0 1992 Beta-carotene and/or vitamin E as modulators of alkylating agents in SCC-25 human squamous carcinoma cells. Vitamin E 21-30 serpin family B member 3 Homo sapiens 69-72 1733553-9 1992 Treatment with beta-carotene, vitamin E, or canthaxanthin reduced the incorporation of [3H]-thymidine into SCC-25 cells but not that into normal human keratinocytes. Vitamin E 30-39 serpin family B member 3 Homo sapiens 107-110 1733553-2 1992 We report on the cytotoxicity of beta-carotene, vitamin E, and the combination of beta-carotene and vitamin E in human SCC-25 squamous carcinoma cells under various environmental conditions found in solid tumor masses. beta Carotene 33-46 serpin family B member 3 Homo sapiens 119-122 1733553-9 1992 Treatment with beta-carotene, vitamin E, or canthaxanthin reduced the incorporation of [3H]-thymidine into SCC-25 cells but not that into normal human keratinocytes. Canthaxanthin 44-57 serpin family B member 3 Homo sapiens 107-110 1733553-2 1992 We report on the cytotoxicity of beta-carotene, vitamin E, and the combination of beta-carotene and vitamin E in human SCC-25 squamous carcinoma cells under various environmental conditions found in solid tumor masses. beta Carotene 82-95 serpin family B member 3 Homo sapiens 119-122 1733553-9 1992 Treatment with beta-carotene, vitamin E, or canthaxanthin reduced the incorporation of [3H]-thymidine into SCC-25 cells but not that into normal human keratinocytes. 3h]-thymidine 88-101 serpin family B member 3 Homo sapiens 107-110 1733553-2 1992 We report on the cytotoxicity of beta-carotene, vitamin E, and the combination of beta-carotene and vitamin E in human SCC-25 squamous carcinoma cells under various environmental conditions found in solid tumor masses. Vitamin E 100-109 serpin family B member 3 Homo sapiens 119-122 1733553-10 1992 The most marked reduction in [3H]-thymidine incorporation into SCC-25 cells occurred following treatment with the combination of beta-carotene and melphalan. Tritium 30-32 serpin family B member 3 Homo sapiens 63-66 1733553-5 1992 Beta-Carotene was an effective modulator of cisplatin (CDDP) cytotoxicity toward SCC-25 cells, whereas vitamin E was not. beta Carotene 0-13 serpin family B member 3 Homo sapiens 81-84 1733553-10 1992 The most marked reduction in [3H]-thymidine incorporation into SCC-25 cells occurred following treatment with the combination of beta-carotene and melphalan. Thymidine 34-43 serpin family B member 3 Homo sapiens 63-66 1733553-10 1992 The most marked reduction in [3H]-thymidine incorporation into SCC-25 cells occurred following treatment with the combination of beta-carotene and melphalan. beta Carotene 129-142 serpin family B member 3 Homo sapiens 63-66 1733553-10 1992 The most marked reduction in [3H]-thymidine incorporation into SCC-25 cells occurred following treatment with the combination of beta-carotene and melphalan. Melphalan 147-156 serpin family B member 3 Homo sapiens 63-66 1733553-5 1992 Beta-Carotene was an effective modulator of cisplatin (CDDP) cytotoxicity toward SCC-25 cells, whereas vitamin E was not. Cisplatin 44-53 serpin family B member 3 Homo sapiens 81-84 1733553-5 1992 Beta-Carotene was an effective modulator of cisplatin (CDDP) cytotoxicity toward SCC-25 cells, whereas vitamin E was not. Cisplatin 55-59 serpin family B member 3 Homo sapiens 81-84 1733553-6 1992 Both beta-carotene and vitamin E were effective modulators of melphalan cytotoxicity toward SCC-25 cells. beta Carotene 5-18 serpin family B member 3 Homo sapiens 92-95 1733553-6 1992 Both beta-carotene and vitamin E were effective modulators of melphalan cytotoxicity toward SCC-25 cells. Vitamin E 23-32 serpin family B member 3 Homo sapiens 92-95 1733553-7 1992 Treatment of SCC-25 cells with beta-carotene (70 microM, 2h) resulted in a reduction in superoxide dismutase activity, in glutathione-S-transferase activity, and in nonprotein sulfhydryl levels in the cells. beta Carotene 31-44 serpin family B member 3 Homo sapiens 13-16 1733553-7 1992 Treatment of SCC-25 cells with beta-carotene (70 microM, 2h) resulted in a reduction in superoxide dismutase activity, in glutathione-S-transferase activity, and in nonprotein sulfhydryl levels in the cells. Deuterium 57-59 serpin family B member 3 Homo sapiens 13-16 1733553-8 1992 Exposure to vitamin E or to a combination of beta-carotene and vitamin E increased the glutathione-S-transferase activity in SCC-25 cells by 40%-45% over the control value. Vitamin E 12-21 serpin family B member 3 Homo sapiens 125-128 1733553-8 1992 Exposure to vitamin E or to a combination of beta-carotene and vitamin E increased the glutathione-S-transferase activity in SCC-25 cells by 40%-45% over the control value. beta Carotene 45-58 serpin family B member 3 Homo sapiens 125-128 1965187-14 1990 CAT activities expressed by the promoter regions of the normal genes in the presence or absence of cAMP in Y-1 cells were almost equal to that by the promoter region of human P-450(SCC) gene. Cyclic AMP 99-103 serpin family B member 3 Homo sapiens 175-185 1382504-1 1992 Human head and neck squamous cell carcinogenesis (SCC) is a common malignancy that appears to be related to continuous exposure to putative carcinogens or promoters such as tobacco and alcohol. Alcohols 185-192 serpin family B member 3 Homo sapiens 50-53 1382504-9 1992 We obtained a partial sequence of exon 2 of the Ha-ras gene and detected an A182----T transversion in codon 61 in hamster cheek-pouch SCC induced by 7,12-dimethylbenz(a)anthracene. 7,12-dimethylbenz 149-166 serpin family B member 3 Homo sapiens 134-137 1382504-9 1992 We obtained a partial sequence of exon 2 of the Ha-ras gene and detected an A182----T transversion in codon 61 in hamster cheek-pouch SCC induced by 7,12-dimethylbenz(a)anthracene. anthracene 169-179 serpin family B member 3 Homo sapiens 134-137 1991985-7 1991 It appears that SCC-NB have lost the ability to synthesize Ch6S, and that SCC-BD degrade Ch6S although they continue to produce it. ch6s 59-63 serpin family B member 3 Homo sapiens 16-19 1991985-7 1991 It appears that SCC-NB have lost the ability to synthesize Ch6S, and that SCC-BD degrade Ch6S although they continue to produce it. ch6s 89-93 serpin family B member 3 Homo sapiens 74-77 1991985-8 1991 Thus, it appears that in SCC the BM is qualitatively different from that of normal epidermis, and that SCC-BD can be distinguished from SCC-NB by the Ch6S content of the BM. ch6s 150-154 serpin family B member 3 Homo sapiens 103-106 1991985-8 1991 Thus, it appears that in SCC the BM is qualitatively different from that of normal epidermis, and that SCC-BD can be distinguished from SCC-NB by the Ch6S content of the BM. ch6s 150-154 serpin family B member 3 Homo sapiens 103-106 1993145-5 1991 A positive correlation was observed between the development of SCC and the total UVA dosage, the age of the patient at the start of the PUVA treatment and a history of arsenic use. Arsenic 168-175 serpin family B member 3 Homo sapiens 63-66 2162247-3 1990 Seven different human small cell lung carcinoma (SCC) cell lines were also found to bind 125I-omega CTx. 125i-omega ctx 89-103 serpin family B member 3 Homo sapiens 49-52 2208001-7 1990 These results indicate that TA-4 is an antigen related to the differentiation of squamous cells and that tumor cells of SCC can release a large amount of TA-4 into circulation whereas normal squamous epithelia cannot. ta-4 28-32 serpin family B member 3 Homo sapiens 120-123 2208001-7 1990 These results indicate that TA-4 is an antigen related to the differentiation of squamous cells and that tumor cells of SCC can release a large amount of TA-4 into circulation whereas normal squamous epithelia cannot. ta-4 154-158 serpin family B member 3 Homo sapiens 120-123 2170881-1 1990 Technetium-99m(99Tcm) (V) dimercaptosuccinic acid is a new imaging agent which has been used to evaluate head and neck squamous cell carcinoma (SCC). Technetium 0-14 serpin family B member 3 Homo sapiens 144-147 2170881-1 1990 Technetium-99m(99Tcm) (V) dimercaptosuccinic acid is a new imaging agent which has been used to evaluate head and neck squamous cell carcinoma (SCC). Succimer 26-49 serpin family B member 3 Homo sapiens 144-147 2170881-7 1990 These results show that although 99Tcm(V)DMSA is accumulated at sites of SCC, the localization process is nonspecific. Succimer 41-45 serpin family B member 3 Homo sapiens 73-76 2162247-7 1990 Fura2 experiments also demonstrated that, in addition to omega CTx-sensitive calcium channels, SCC cell lines also expressed omega CTx-insensitive calcium channels, which were antagonized by nitrendipine and verapamil. Fura-2 0-5 serpin family B member 3 Homo sapiens 95-98 2162247-7 1990 Fura2 experiments also demonstrated that, in addition to omega CTx-sensitive calcium channels, SCC cell lines also expressed omega CTx-insensitive calcium channels, which were antagonized by nitrendipine and verapamil. Nitrendipine 191-203 serpin family B member 3 Homo sapiens 95-98 2162247-7 1990 Fura2 experiments also demonstrated that, in addition to omega CTx-sensitive calcium channels, SCC cell lines also expressed omega CTx-insensitive calcium channels, which were antagonized by nitrendipine and verapamil. Verapamil 208-217 serpin family B member 3 Homo sapiens 95-98 2162247-8 1990 125I-omega CTx-labeled VOCCs from SCC cells were, furthermore, precipitated by anti-VOCC autoantibodies obtained from patients affected by the Lambert-Eaton myasthenic syndrome, a neuromuscular disease often associated with SCC. 125i-omega ctx 0-14 serpin family B member 3 Homo sapiens 34-37 2162247-8 1990 125I-omega CTx-labeled VOCCs from SCC cells were, furthermore, precipitated by anti-VOCC autoantibodies obtained from patients affected by the Lambert-Eaton myasthenic syndrome, a neuromuscular disease often associated with SCC. 125i-omega ctx 0-14 serpin family B member 3 Homo sapiens 224-227 1696099-0 1990 In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate. Peplomycin 127-137 serpin family B member 3 Homo sapiens 67-70 2340474-10 1990 Watermen in the upper quartile of cumulative ultraviolet-B exposure had a 2.5 times higher risk for the development of SCC when compared with the lower 3 quartiles. watermen 0-8 serpin family B member 3 Homo sapiens 119-122 1696099-0 1990 In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate. Butyric Acid 142-157 serpin family B member 3 Homo sapiens 67-70 1696099-1 1990 In order to investigate the effect of an antisquamous cell carcinoma drug, peplomycin, the new analogue of bleomycin, on the production of a squamous cell carcinoma-associated tumor marker termed "SCC" (or TA-4), we carried out in vitro and in vivo experiments using the uterine cervical epidermoid cancer cell line SKG-IIIa, together with the investigation of the effect of sodium butyrate which was reported to be one of the representative gene modulators. Peplomycin 75-85 serpin family B member 3 Homo sapiens 197-200 1696099-1 1990 In order to investigate the effect of an antisquamous cell carcinoma drug, peplomycin, the new analogue of bleomycin, on the production of a squamous cell carcinoma-associated tumor marker termed "SCC" (or TA-4), we carried out in vitro and in vivo experiments using the uterine cervical epidermoid cancer cell line SKG-IIIa, together with the investigation of the effect of sodium butyrate which was reported to be one of the representative gene modulators. Bleomycin 107-116 serpin family B member 3 Homo sapiens 197-200 1696099-1 1990 In order to investigate the effect of an antisquamous cell carcinoma drug, peplomycin, the new analogue of bleomycin, on the production of a squamous cell carcinoma-associated tumor marker termed "SCC" (or TA-4), we carried out in vitro and in vivo experiments using the uterine cervical epidermoid cancer cell line SKG-IIIa, together with the investigation of the effect of sodium butyrate which was reported to be one of the representative gene modulators. Butyric Acid 375-390 serpin family B member 3 Homo sapiens 197-200 1696099-3 1990 Immunocytochemistry using anti-SCC antibody revealed that the total number of SCC-positive cells increased after the treatment with peplomycin (1.6 fold) or sodium butyrate (1.5 fold). Peplomycin 132-142 serpin family B member 3 Homo sapiens 31-34 1696099-3 1990 Immunocytochemistry using anti-SCC antibody revealed that the total number of SCC-positive cells increased after the treatment with peplomycin (1.6 fold) or sodium butyrate (1.5 fold). Peplomycin 132-142 serpin family B member 3 Homo sapiens 78-81 1696099-3 1990 Immunocytochemistry using anti-SCC antibody revealed that the total number of SCC-positive cells increased after the treatment with peplomycin (1.6 fold) or sodium butyrate (1.5 fold). Butyric Acid 157-172 serpin family B member 3 Homo sapiens 31-34 1696099-3 1990 Immunocytochemistry using anti-SCC antibody revealed that the total number of SCC-positive cells increased after the treatment with peplomycin (1.6 fold) or sodium butyrate (1.5 fold). Butyric Acid 157-172 serpin family B member 3 Homo sapiens 78-81 1696099-4 1990 The total amount of SCC in cultured medium, intracellular SCC, and cell debris during 5 days of culturation also increased with peplomycin (1.8 fold) and sodium butyrate (1.4 fold). Peplomycin 128-138 serpin family B member 3 Homo sapiens 20-23 1696099-4 1990 The total amount of SCC in cultured medium, intracellular SCC, and cell debris during 5 days of culturation also increased with peplomycin (1.8 fold) and sodium butyrate (1.4 fold). Peplomycin 128-138 serpin family B member 3 Homo sapiens 58-61 1696099-4 1990 The total amount of SCC in cultured medium, intracellular SCC, and cell debris during 5 days of culturation also increased with peplomycin (1.8 fold) and sodium butyrate (1.4 fold). Butyric Acid 154-169 serpin family B member 3 Homo sapiens 20-23 1696099-4 1990 The total amount of SCC in cultured medium, intracellular SCC, and cell debris during 5 days of culturation also increased with peplomycin (1.8 fold) and sodium butyrate (1.4 fold). Butyric Acid 154-169 serpin family B member 3 Homo sapiens 58-61 2232291-4 1990 The specimens for this study were paraffin-embedded tissue section of SCC stained with azocarmin G for blocking the non-specific fluorescence. Paraffin 34-42 serpin family B member 3 Homo sapiens 70-73 2179417-9 1990 In one SCC, a point mutation was detected at codon 12 of the K-ras gene, involving a glycine to cysteine substitution in the gene product. Glycine 85-92 serpin family B member 3 Homo sapiens 7-10 1966928-1 1990 The quantitation of leukotriene B4 (LTB4) in induced squamous cell carcinoma (SCC) of the Syrian hamster cheek pouch and histologically proven human oral SCC was investigated by a combination of reverse phase-high performance liquid chromatography (RP-HPLC) and radioimmunoassay (RIA). Leukotriene B4 20-34 serpin family B member 3 Homo sapiens 78-81 1966928-1 1990 The quantitation of leukotriene B4 (LTB4) in induced squamous cell carcinoma (SCC) of the Syrian hamster cheek pouch and histologically proven human oral SCC was investigated by a combination of reverse phase-high performance liquid chromatography (RP-HPLC) and radioimmunoassay (RIA). Leukotriene B4 20-34 serpin family B member 3 Homo sapiens 154-157 2358334-1 1990 The results of treatment of 341 previously untreated patients with early squamous cell carcinoma (SCC) of the anterior two thirds of the tongue using iridium 192 implants (January 1974-December 1983) are presented. Iridium 150-157 serpin family B member 3 Homo sapiens 98-101 1696099-5 1990 These data strongly suggest that SCC production of SKG-IIIa cells is stimulated by peplomycin and sodium butyrate in vitro. Peplomycin 83-93 serpin family B member 3 Homo sapiens 33-36 1696099-5 1990 These data strongly suggest that SCC production of SKG-IIIa cells is stimulated by peplomycin and sodium butyrate in vitro. Butyric Acid 98-113 serpin family B member 3 Homo sapiens 33-36 1696099-6 1990 In vivo experiments were also performed by administering peplomycin to nude rats with heterotransplanted tumors of SKG-IIIa, and transient elevations of serum SCC level (113% to 238% of the initial values) were observed, suggesting that SCC production of cancer cells is also stimulated by peplomycin in vivo. Peplomycin 57-67 serpin family B member 3 Homo sapiens 159-162 1696099-6 1990 In vivo experiments were also performed by administering peplomycin to nude rats with heterotransplanted tumors of SKG-IIIa, and transient elevations of serum SCC level (113% to 238% of the initial values) were observed, suggesting that SCC production of cancer cells is also stimulated by peplomycin in vivo. Peplomycin 57-67 serpin family B member 3 Homo sapiens 237-240 1696099-6 1990 In vivo experiments were also performed by administering peplomycin to nude rats with heterotransplanted tumors of SKG-IIIa, and transient elevations of serum SCC level (113% to 238% of the initial values) were observed, suggesting that SCC production of cancer cells is also stimulated by peplomycin in vivo. Peplomycin 290-300 serpin family B member 3 Homo sapiens 159-162 2164650-1 1990 Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. Technetium-99 0-13 serpin family B member 3 Homo sapiens 139-142 2164650-1 1990 Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. Succimer 26-49 serpin family B member 3 Homo sapiens 139-142 2164650-1 1990 Technetium-99m (99Tcm)(V) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to evaluate squamous carcinoma (SCC) of the head and neck. Succimer 51-55 serpin family B member 3 Homo sapiens 139-142 2179417-9 1990 In one SCC, a point mutation was detected at codon 12 of the K-ras gene, involving a glycine to cysteine substitution in the gene product. Cysteine 96-104 serpin family B member 3 Homo sapiens 7-10 2302769-4 1990 Specificity of SCC increased (91.1%) when we excluded patients in renal failure or with creatinine values greater than 133 mumol/L. Creatinine 88-98 serpin family B member 3 Homo sapiens 15-18 2338998-6 1990 SCC and NAG showed significant negative correlations with MAN, GAL and GLU, the latter being the only parameter significantly correlated with each of the other parameters. Galactose 63-66 serpin family B member 3 Homo sapiens 0-3 2338998-6 1990 SCC and NAG showed significant negative correlations with MAN, GAL and GLU, the latter being the only parameter significantly correlated with each of the other parameters. Glucose 71-74 serpin family B member 3 Homo sapiens 0-3 2153134-2 1990 In testing the possibility that VGCC may be functionally coupled to mAChR in SCC cell lines, we found that depolarization-dependent Ca2+ influx was inhibited by carbachol (IC50 = 0.78 microM) and oxotremorine (IC50 = 0.69 microM). Carbachol 161-170 serpin family B member 3 Homo sapiens 77-80 2153134-4 1990 Exposure of SCC to carbachol induced the hydrolysis of phosphoinositides and increased the cytosolic free Ca2+ concentration ([Ca2+]i). Carbachol 19-28 serpin family B member 3 Homo sapiens 12-15 2153134-4 1990 Exposure of SCC to carbachol induced the hydrolysis of phosphoinositides and increased the cytosolic free Ca2+ concentration ([Ca2+]i). Phosphatidylinositols 55-72 serpin family B member 3 Homo sapiens 12-15 2162508-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. Technetium-99 0-13 serpin family B member 3 Homo sapiens 181-184 2144980-6 1990 Since inhibition of PG production has been demonstrated to suppress growth of tumors in animal models and humans, further study on the effect of retinoids on growth of SCC in vitro as well as in vivo seems warranted. Retinoids 145-154 serpin family B member 3 Homo sapiens 168-171 2162508-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. Succimer 27-50 serpin family B member 3 Homo sapiens 181-184 2162508-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image medullary carcinoma of the thyroid and squamous cell carcinoma (SCC) of the head and neck. Succimer 52-56 serpin family B member 3 Homo sapiens 181-184 2162509-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. Technetium-99 0-13 serpin family B member 3 Homo sapiens 142-145 2162509-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. Succimer 27-50 serpin family B member 3 Homo sapiens 142-145 2162509-1 1990 Technetium-99m (99Tcm) (v) dimercaptosuccinic acid (DMSA) is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. Succimer 52-56 serpin family B member 3 Homo sapiens 142-145 2162509-2 1990 This study was undertaken to compare planar versus SPECT 99Tcm (v) DMSA scintigraphy in patients with head and neck SCC. Succimer 67-71 serpin family B member 3 Homo sapiens 116-119 9801680-3 1998 Our objective was to determine if a pulsed CO2 laser could effectively ablate superficial malignant cutaneous neoplasms (superficial multifocal basal cell carcinoma [BCC] and squamous cell carcinoma [SCC] in situ). Carbon Dioxide 43-46 serpin family B member 3 Homo sapiens 200-203 34115900-11 2021 CONCLUSIONS: Our results suggest that LC-OCT can help clinicians in the identification of AK and SCC and their differentiation, providing a real-time and non-invasive examination. lc-oct 38-44 serpin family B member 3 Homo sapiens 97-100 34710250-9 2022 Low doses of etoposide combined with the PARP5B inhibitor XAV939 induced senescence and apoptosis in human SCC lines. Etoposide 13-22 serpin family B member 3 Homo sapiens 107-110 34710250-9 2022 Low doses of etoposide combined with the PARP5B inhibitor XAV939 induced senescence and apoptosis in human SCC lines. XAV939 58-64 serpin family B member 3 Homo sapiens 107-110 34472131-1 2021 Although oral cytology using Papanicolaou stain is useful for the early detection of oral premalignant lesions and squamous cell carcinoma (SCC) in people, little work has been conducted on this topic in veterinary medicine. papanicolaou 29-41 serpin family B member 3 Homo sapiens 140-143 34603888-5 2021 We present a case of a 47-year-old Caucasian female with rectal SCC who is under remission for two years after being treated with upfront chemoradiation with mitomycin and 5-fluorouracil (5-FU). Mitomycin 158-167 serpin family B member 3 Homo sapiens 64-67 34603888-5 2021 We present a case of a 47-year-old Caucasian female with rectal SCC who is under remission for two years after being treated with upfront chemoradiation with mitomycin and 5-fluorouracil (5-FU). Fluorouracil 172-186 serpin family B member 3 Homo sapiens 64-67 34603888-5 2021 We present a case of a 47-year-old Caucasian female with rectal SCC who is under remission for two years after being treated with upfront chemoradiation with mitomycin and 5-fluorouracil (5-FU). Fluorouracil 188-192 serpin family B member 3 Homo sapiens 64-67 34451800-2 2021 SerpinB3 is a serine protease inhibitor that has shown a protective anti-apoptotic function in a variety of stressful conditions. Serine 14-20 serpin family B member 3 Homo sapiens 0-8 34451800-3 2021 The aim of this study was to evaluate protection from oxidative stress-induced damage, using extracellular vesicles that overexpress SerpinB3 (EVs-SB3) in order to enhance the effect of extracellular vesicles on cellular homeostasis. evs-sb3 143-150 serpin family B member 3 Homo sapiens 133-141 35056397-8 2022 Conclusions: We presented data from the largest series on patients with TCC and concomitant SCC histological variant managed with intravesical therapy (BCG or MMC). Mitomycin 159-162 serpin family B member 3 Homo sapiens 92-95 35086087-2 2022 Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism. Folic Acid 36-42 serpin family B member 3 Homo sapiens 158-161 35086087-2 2022 Dark green leafy vegetables contain folate as a main component among other nutrients; thus, we hypothesised that their possible observed protective effect on SCC, observed in previous studies, would be more evident in persons with specific genotypes related to folate metabolism. Folic Acid 261-267 serpin family B member 3 Homo sapiens 158-161 34188993-4 2021 Menopause is an independent risk factor for esophageal cancer while usage of hormonal therapy (estrogen plus progesterone) is associated with a lower risk of esophageal SCC in postmenopausal women. Progesterone 109-121 serpin family B member 3 Homo sapiens 169-172 2628548-0 1989 Quantitative investigation of copper(II) and zinc(II) complexes with S-carboxymethyl-L-cysteine and computer-simulated appraisal of their potential significance in vivo. cupric ion 30-40 serpin family B member 3 Homo sapiens 69-95 2628548-0 1989 Quantitative investigation of copper(II) and zinc(II) complexes with S-carboxymethyl-L-cysteine and computer-simulated appraisal of their potential significance in vivo. Zinc 45-53 serpin family B member 3 Homo sapiens 69-95 2628548-3 1989 Copper(II)- and zinc(II)-SCC complex equilibria have thus been investigated under physiological conditions by means of classical potentiometry combined with computer-assisted calculation techniques. Zinc 16-24 serpin family B member 3 Homo sapiens 25-28 2480245-1 1989 Cis-platinum, 5-fluorouracil and bleomycin are active agents in head and neck SCC. Cisplatin 0-12 serpin family B member 3 Homo sapiens 78-81 2480245-1 1989 Cis-platinum, 5-fluorouracil and bleomycin are active agents in head and neck SCC. Fluorouracil 14-28 serpin family B member 3 Homo sapiens 78-81 2480245-1 1989 Cis-platinum, 5-fluorouracil and bleomycin are active agents in head and neck SCC. Bleomycin 33-42 serpin family B member 3 Homo sapiens 78-81 2559379-2 1989 99Tcm-(V)-DMSA is a new tumour imaging agent which has been used to image squamous cell carcinoma (SCC) of the head and neck. 99tcm-(v)-dmsa 0-14 serpin family B member 3 Homo sapiens 99-102 2560154-1 1989 99Tcm(v)-DMSA is a new tumour-imaging agent which has recently been proposed as a scintigraphic marker for head and neck squamous cell carcinoma (SCC). Succimer 9-13 serpin family B member 3 Homo sapiens 146-149 2560154-7 1989 Although 99Tcm(v)-DMSA is accumulated at sites of head and neck SCC, its inability to detect low volume disease and apparent low specificity following surgery and irradiation means it has no role to play in the routine evaluation of patients with head and neck SCC. Succimer 18-22 serpin family B member 3 Homo sapiens 64-67 2434208-10 1987 Non-keratinizing SCC had CRs of 98% (ALL), and 94% (REST), as compared with 64% and 67% in the patients with keratin producing neoplasms (P less than 0.001 and 0.05) respectively. Chromium 25-28 serpin family B member 3 Homo sapiens 17-20 2544690-1 1989 A recently developed imaging agent, technetium-99m (v) dimercaptosuccinic acid (99mTc (v) DMSA), has been used to assess head and neck squamous carcinoma (SCC). Technetium-99 36-49 serpin family B member 3 Homo sapiens 155-158 2840221-3 1988 Difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC) which produces minimal toxicity in animals and humans, has shown antiproliferative effect against human SCC in culture but a much smaller effect (cytostatic) against NSCC. Eflornithine 0-23 serpin family B member 3 Homo sapiens 207-210 2840221-3 1988 Difluoromethylornithine (DFMO), a specific and irreversible inhibitor of ornithine decarboxylase (ODC) which produces minimal toxicity in animals and humans, has shown antiproliferative effect against human SCC in culture but a much smaller effect (cytostatic) against NSCC. Eflornithine 25-29 serpin family B member 3 Homo sapiens 207-210 3436953-0 1987 Interaction of synthetic fragments of the extension peptide of cytochrome P-450(SCC) precursor with phospholipid bilayer. Phospholipids 100-112 serpin family B member 3 Homo sapiens 63-84 3665673-1 1987 Intense interest in advanced squamous cell cancers of the head and neck (SCC of H&N) has resulted from the recent progress made in tumor responses with chemotherapy and radiotherapy. Adenosine Monophosphate 82-85 serpin family B member 3 Homo sapiens 73-76 2782919-1 1989 A 69 year-old woman with recurrent uterine cervical cancer was treated by etoposide because of ascites retention and elevated serum SCC level. Etoposide 74-83 serpin family B member 3 Homo sapiens 132-135 2551943-3 1989 Two of the responding SCC had been resistant to previous chemotherapy, including peplomycin and mitomycin C. Peplomycin 81-91 serpin family B member 3 Homo sapiens 22-25 2551943-3 1989 Two of the responding SCC had been resistant to previous chemotherapy, including peplomycin and mitomycin C. Mitomycin 96-107 serpin family B member 3 Homo sapiens 22-25 2649011-7 1989 This study confirms a previous report of an increase in the incidence of SCC in psoriatic patients treated with PUVA. puva 112-116 serpin family B member 3 Homo sapiens 73-76 2520755-1 1989 We found previously that Ac-(Leu-Leu-Ala-Arg-Leu)3-NHCH3 (5(3)), a model of the extension peptide of cytochrome P-450(SCC) precursor, strongly inhibited the import of the precursor into mitochondria. ac-(leu-leu-ala-arg-leu)3-nhch3 25-56 serpin family B member 3 Homo sapiens 101-122 2544690-1 1989 A recently developed imaging agent, technetium-99m (v) dimercaptosuccinic acid (99mTc (v) DMSA), has been used to assess head and neck squamous carcinoma (SCC). Succimer 55-78 serpin family B member 3 Homo sapiens 155-158 2544690-1 1989 A recently developed imaging agent, technetium-99m (v) dimercaptosuccinic acid (99mTc (v) DMSA), has been used to assess head and neck squamous carcinoma (SCC). Succimer 90-94 serpin family B member 3 Homo sapiens 155-158 2544690-8 1989 This study has shown 99mTc (v) DMSA imaging provides a cheap and rapid method of investigating head and neck SCC and further studies are necessary to evaluate its role in the management of patients with this disease. Succimer 31-35 serpin family B member 3 Homo sapiens 109-112 2457429-6 1988 Adenosine, reported to be a specific antagonist of neuronal Ca2+ channels, also impaired voltage-stimulated Ca2+ influx in SCC. Adenosine 0-9 serpin family B member 3 Homo sapiens 123-126 2831049-0 1988 The 5"-flanking region of the human P-450(SCC) gene shows responsiveness to cAMP-dependent regulation in a transient gene-expression system of Y-1 adrenal tumor cells. Cyclic AMP 76-80 serpin family B member 3 Homo sapiens 36-46 2831049-2 1988 P-450(SCC), one of the enzymes, catalyzes the first and the rate-limiting reaction in steroidogenesis from cholesterol and its synthesis is regulated by cAMP. Cholesterol 107-118 serpin family B member 3 Homo sapiens 0-10 2831049-2 1988 P-450(SCC), one of the enzymes, catalyzes the first and the rate-limiting reaction in steroidogenesis from cholesterol and its synthesis is regulated by cAMP. Cyclic AMP 153-157 serpin family B member 3 Homo sapiens 0-10 3436955-0 1987 Site-directed mutagenesis of basic amino acid residues in the extension peptide of P-450(SCC) precursor: effects on the import of the precursor into mitochondria. Amino Acids, Basic 29-45 serpin family B member 3 Homo sapiens 83-93 3436955-3 1987 To investigate their role in the import of preP-450(SCC) into mitochondria, they were replaced by other amino acids, Ser or Thr, by site-directed mutagenesis. Serine 117-120 serpin family B member 3 Homo sapiens 52-55 3295052-3 1987 S-Carbamyl-L-cysteine (SCC), an inhibitor of human lymphocyte AdoMet synthetase, reduced AdoMet levels and inhibited the blastogenic response of PB lymphocytes to both M5 protein and PHA. S-carbamylcysteine 0-21 serpin family B member 3 Homo sapiens 23-26 3091839-3 1986 Pulses of 1 M NaCl injected into the outer compartment induced sharp increases of the SCC following a time course variable with the magnitude of the pulse and the particular condition of each skin. Sodium Chloride 14-18 serpin family B member 3 Homo sapiens 86-89 3038854-9 1987 The mature form of human P-450(SCC) has only one cysteine residue, which was located in the center of the HR2 region (Gotoh et al. Cysteine 49-57 serpin family B member 3 Homo sapiens 25-35 3793272-0 1987 In vitro effects of tamoxifen on UM-SCC head and neck cancer cell lines: correlation with the estrogen and progesterone receptor content. Tamoxifen 20-29 serpin family B member 3 Homo sapiens 36-39 3793272-5 1987 Eight of the 11 SCC lines and MCF-7 showed more than 60% growth inhibition when fed with 5 microM tamoxifen. Tamoxifen 98-107 serpin family B member 3 Homo sapiens 16-19 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Tamoxifen 107-116 serpin family B member 3 Homo sapiens 35-38 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Tamoxifen 107-116 serpin family B member 3 Homo sapiens 54-57 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Tamoxifen 107-116 serpin family B member 3 Homo sapiens 54-57 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Estradiol 153-170 serpin family B member 3 Homo sapiens 35-38 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Estradiol 153-170 serpin family B member 3 Homo sapiens 54-57 3793272-9 1987 MCF-7 and two ER- and PgR-positive SCC cell lines, UM-SCC-12 and UM-SCC-9, recovered more rapidly when the tamoxifen was replaced with medium containing 17-beta estradiol (E2) than when it was replaced with D5 medium alone. Estradiol 153-170 serpin family B member 3 Homo sapiens 54-57 2436565-1 1987 The schedule-dependent effect of bleomycin (BLM) on human squamous cell carcinoma (SCC) was investigated using a xenografted SCC line originating from the head and neck region. Bleomycin 33-42 serpin family B member 3 Homo sapiens 83-86 3004707-4 1986 Moreover, in the spectrum of human lung carcinoma cells in culture, the SCC cells respond in a cytotoxic manner to DFMO, whereas the non-small cell lung carcinoma (non-SCC) cells, which are anchorage dependent, show only growth inhibition, without actual cell loss. Eflornithine 115-119 serpin family B member 3 Homo sapiens 72-75 3004707-6 1986 Two non-SCC lung cancer cell lines, which normally grow as anchorage-dependent monolayers, show growth inhibition but no cell loss with the addition of DFMO. Eflornithine 152-156 serpin family B member 3 Homo sapiens 8-11 3755989-0 1986 Growth inhibition of laryngeal UM-SCC cell lines by tamoxifen. Tamoxifen 52-61 serpin family B member 3 Homo sapiens 34-37 3755989-7 1986 These findings indicate that there are at least two tamoxifen receptor sites--one for which estradiol is a competitor and one for which it is not--and that tamoxifen reversibly blocks growth and may synchronize SCC cells. Estradiol 92-101 serpin family B member 3 Homo sapiens 211-214 3091839-4 1986 Comparison of the spontaneous decline of the SCC with the decline induced by a small dose of amiloride, where an increase in R was observed, indicates that the spontaneous decline cannot be explained simply as a reduction of the Na permeability of the apical membrane by self-inhibition of feedback inhibition of the apical membrane Na channels. Amiloride 93-102 serpin family B member 3 Homo sapiens 45-48 3891641-5 1985 Five out of 7 SCC lines showed a shift in GAG production compared with normal keratinocytes, so that in these lines heparan sulphate was the major GAG as opposed to hyaluronic acid in the normal keratinocytes. Glycosaminoglycans 42-45 serpin family B member 3 Homo sapiens 14-17 2996509-5 1985 High activity was also observed using 5-L-hydroxytryptophan as a substrate (5-HTP decarboxylase) in nine SCC samples. 5-l-hydroxytryptophan 38-59 serpin family B member 3 Homo sapiens 105-108 2996509-6 1985 Serotonin was not detected in any control lung tissues, but was detected in all the nine SCC samples, but dopamine was detected only in three out of nine SCC samples. Serotonin 0-9 serpin family B member 3 Homo sapiens 89-92 2996509-6 1985 Serotonin was not detected in any control lung tissues, but was detected in all the nine SCC samples, but dopamine was detected only in three out of nine SCC samples. Dopamine 106-114 serpin family B member 3 Homo sapiens 154-157 2994574-8 1985 Although surgery is the first choice of treatment for skin cancer and precancerous disease, peplomycin is very effective for scc. Peplomycin 92-102 serpin family B member 3 Homo sapiens 125-128 2994575-6 1985 It was noticed that the cell cycle times (Tc) of SCC were statistically shorter than those of controls and this short Tc was found to be dependent on their short post-mitotic resting phases. Technetium 42-44 serpin family B member 3 Homo sapiens 49-52 3891641-5 1985 Five out of 7 SCC lines showed a shift in GAG production compared with normal keratinocytes, so that in these lines heparan sulphate was the major GAG as opposed to hyaluronic acid in the normal keratinocytes. Heparitin Sulfate 116-132 serpin family B member 3 Homo sapiens 14-17 3891641-5 1985 Five out of 7 SCC lines showed a shift in GAG production compared with normal keratinocytes, so that in these lines heparan sulphate was the major GAG as opposed to hyaluronic acid in the normal keratinocytes. Glycosaminoglycans 147-150 serpin family B member 3 Homo sapiens 14-17 3891641-5 1985 Five out of 7 SCC lines showed a shift in GAG production compared with normal keratinocytes, so that in these lines heparan sulphate was the major GAG as opposed to hyaluronic acid in the normal keratinocytes. Hyaluronic Acid 165-180 serpin family B member 3 Homo sapiens 14-17 6261931-4 1981 Gallium-67 scans proved to be accurate in detecting thoracic and extrathoracic metastases in the 30 patients with SCC, especially within the liver and lymph node-bearing area. Gallium 0-7 serpin family B member 3 Homo sapiens 114-117 3857370-6 1985 For both ADC and SCC, increased risks were associated with decreased intake of beta-carotene foods but not for total preformed vitamin A foods and vitamin supplements. beta Carotene 79-92 serpin family B member 3 Homo sapiens 17-20 3970817-5 1985 Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC. Oxygen 109-115 serpin family B member 3 Homo sapiens 230-233 3970817-5 1985 Using measured values for cord radius and published equations that describe the diffusion and consumption of oxygen in metabolising tissue, an attempt was made to calculate the oxygen partial pressure in vessels of cords of these SCC. Oxygen 177-183 serpin family B member 3 Homo sapiens 230-233 6289311-1 1982 We have used radioiodination (125I) and two-dimensional polyacrylamide gel electrophoresis to determine that small- (oat) cell lung carcinoma (SCC)--a tumor with neuroendocrine features--possesses a surface protein pattern distinct from the other types of lung cancer cells (squamous, adeno-, and large-cell undifferentiated carcinoma). polyacrylamide 56-70 serpin family B member 3 Homo sapiens 143-146 2987408-7 1985 In the presence of the guanine nucleotide analogue 5"-guanylyl imidodiphosphate, a decrease in affinity of the mAChR of SCC for oxotremorine was observed, with an increase in the pseudo-Hill coefficient, but there was no change in the binding of atropine. Guanine Nucleotides 23-41 serpin family B member 3 Homo sapiens 120-123 2987408-7 1985 In the presence of the guanine nucleotide analogue 5"-guanylyl imidodiphosphate, a decrease in affinity of the mAChR of SCC for oxotremorine was observed, with an increase in the pseudo-Hill coefficient, but there was no change in the binding of atropine. Guanylyl Imidodiphosphate 51-79 serpin family B member 3 Homo sapiens 120-123 2987408-7 1985 In the presence of the guanine nucleotide analogue 5"-guanylyl imidodiphosphate, a decrease in affinity of the mAChR of SCC for oxotremorine was observed, with an increase in the pseudo-Hill coefficient, but there was no change in the binding of atropine. Oxotremorine 128-140 serpin family B member 3 Homo sapiens 120-123 2987408-7 1985 In the presence of the guanine nucleotide analogue 5"-guanylyl imidodiphosphate, a decrease in affinity of the mAChR of SCC for oxotremorine was observed, with an increase in the pseudo-Hill coefficient, but there was no change in the binding of atropine. Atropine 246-254 serpin family B member 3 Homo sapiens 120-123 2986665-11 1985 Of 32 formalin fixed lung tumour resection specimens 6 were cases of SCC, 25 non-SCC and 1 a chemodectoma. Formaldehyde 6-14 serpin family B member 3 Homo sapiens 69-72 743282-0 1978 The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen. Cholesterol 41-52 serpin family B member 3 Homo sapiens 71-91 7328627-5 1981 Maintenance of aldosterone in the media resulted in a much slower rate of decay of this 10-14 S. It is concluded that the decay of the 10-14 S poly(A)(+)RNA is closely related to the decay in SCC and the stability of this RNA is influenced by the retention of aldosterone in the medium. Aldosterone 15-26 serpin family B member 3 Homo sapiens 192-195 7328627-5 1981 Maintenance of aldosterone in the media resulted in a much slower rate of decay of this 10-14 S. It is concluded that the decay of the 10-14 S poly(A)(+)RNA is closely related to the decay in SCC and the stability of this RNA is influenced by the retention of aldosterone in the medium. Aldosterone 260-271 serpin family B member 3 Homo sapiens 192-195 743282-0 1978 The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen. 20,22-dihydroxycholesterol 116-143 serpin family B member 3 Homo sapiens 71-91 743282-0 1978 The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen. isocaproaldehyde 150-166 serpin family B member 3 Homo sapiens 71-91 743282-0 1978 The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen. Water 173-178 serpin family B member 3 Homo sapiens 71-91 743282-0 1978 The final step of side-chain cleavage of cholesterol by adrenocortical cytochrome P-450(scc) studied with [22(-18)O]20,22-dihydroxycholesterols, [18O]isocaproaldehyde, [18O]water and atmospheric [18O]oxygen. Oxygen 200-206 serpin family B member 3 Homo sapiens 71-91 33687106-6 2021 Strikingly, stimulation of TA in the ventral hippocampus produces facilitation of steady-state responses to 1-30 Hz and highly contrasts with the depression of SC-CA1 synapses. Tantalum 27-29 serpin family B member 3 Homo sapiens 160-166 418180-3 1978 At 2 to 5 mM, harmaline consistently inhibited SCC and prevented the natriferic effects of oxytocin and norepinephrine. Harmaline 14-23 serpin family B member 3 Homo sapiens 47-50 418180-4 1978 However, at 0.1 to 0.5 mM, harmaline produced an increase in SCC inhibitable with amiloride. Harmaline 27-36 serpin family B member 3 Homo sapiens 61-64 418180-4 1978 However, at 0.1 to 0.5 mM, harmaline produced an increase in SCC inhibitable with amiloride. Amiloride 82-91 serpin family B member 3 Homo sapiens 61-64 329688-7 1977 A23187 produced normal stimulation of the SCC in corneas pretreated with alpha- and beta-adrenergic blockers. Calcimycin 0-6 serpin family B member 3 Homo sapiens 42-45 329688-8 1977 The stimulation of the SCC by A23187 was dependent on the presence of Ca in the Ringer solution. Calcimycin 30-36 serpin family B member 3 Homo sapiens 23-26 329688-10 1977 Increasing the Mg concentration in the medium reduced the stimulation of the SCC with Ca concentrations of 0.1-5 mM, but prevented the relative inhibition of 10 mM Ca. Magnesium 15-17 serpin family B member 3 Homo sapiens 77-80 164961-5 1975 Titration of apical membrane SH groups with PCMPS, NTCB, and DTNB revealed heterogeneity in functional responses: PCMPS and NTCB elicited transient, 25-60% increases in SCC. Dithionitrobenzoic Acid 61-65 serpin family B member 3 Homo sapiens 169-172 164961-5 1975 Titration of apical membrane SH groups with PCMPS, NTCB, and DTNB revealed heterogeneity in functional responses: PCMPS and NTCB elicited transient, 25-60% increases in SCC. 4-Chloromercuribenzenesulfonate 114-119 serpin family B member 3 Homo sapiens 169-172 164961-5 1975 Titration of apical membrane SH groups with PCMPS, NTCB, and DTNB revealed heterogeneity in functional responses: PCMPS and NTCB elicited transient, 25-60% increases in SCC. 2-nitro-5-thiocyanobenzoic acid 124-128 serpin family B member 3 Homo sapiens 169-172 164961-6 1975 In substrate-free media, pretreatment with these reagents inhibited the increase in SCC produced by vasopressin or cyclic AMP (+ theophylline). Cyclic AMP 115-125 serpin family B member 3 Homo sapiens 84-87 164961-6 1975 In substrate-free media, pretreatment with these reagents inhibited the increase in SCC produced by vasopressin or cyclic AMP (+ theophylline). Theophylline 129-141 serpin family B member 3 Homo sapiens 84-87 5893230-0 1965 [Mechanism of succinylcholine SCC)-induced arrhythmia]. Succinylcholine 14-29 serpin family B member 3 Homo sapiens 30-33 32791082-2 2021 OBJECTIVES: To characterize the association between HCTZ use and invasive SCC, SCC in situ (SCCis) and basal cell carcinoma (BCC). Hydrochlorothiazide 52-56 serpin family B member 3 Homo sapiens 74-77 34014459-10 2021 Intraoperative cryotherapy in patients with carcinoma in situ and intraoperative cryotherapy with adjuvant topical mitomycin C in those with invasive SCC that is limited to the ocular surface are associated with low tumor recurrence. Mitomycin 115-126 serpin family B member 3 Homo sapiens 150-153 33922660-8 2021 HepG2 overexpressing SerpinB3 cells were more prone to die after oxidizing treatments, such as diamide or high concentration H2O2. Diamide 95-102 serpin family B member 3 Homo sapiens 21-29 33922660-8 2021 HepG2 overexpressing SerpinB3 cells were more prone to die after oxidizing treatments, such as diamide or high concentration H2O2. Hydrogen Peroxide 125-129 serpin family B member 3 Homo sapiens 21-29 32791082-5 2021 RESULTS: A cumulative HCTZ dose above 37,500 mg was associated with increased risk of invasive SCC (OR=1.69, 95% CI: 1.04 - 2.74). Hydrochlorothiazide 22-26 serpin family B member 3 Homo sapiens 95-98 32791082-8 2021 CONCLUSION: High cumulative exposure to HCTZ is associated with the development of keratinocyte carcinoma and, most importantly, invasive SCC. Hydrochlorothiazide 40-44 serpin family B member 3 Homo sapiens 138-141 33610593-1 2021 BACKGROUND: Metformin has anti-carcinogenic properties and is also known to inhibit the Sonic hedgehog pathway, but no population-based studies exist analyzing the potential protective effect for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Metformin 12-21 serpin family B member 3 Homo sapiens 252-255 33610593-2 2021 OBJECTIVES: To delineate the association between metformin use and invasive SCC, SCC in situ (SCCis) and BCC. Metformin 49-58 serpin family B member 3 Homo sapiens 76-79 33610593-2 2021 OBJECTIVES: To delineate the association between metformin use and invasive SCC, SCC in situ (SCCis) and BCC. Metformin 49-58 serpin family B member 3 Homo sapiens 81-84 33164521-0 2020 SCC-DFTB Parameters for Fe-C Interactions. dftb 4-8 serpin family B member 3 Homo sapiens 0-3 32958585-3 2021 A systematic literature search was performed up to March 23, 2020 to identify randomized controlled trials (RCTs) and observational studies of metformin that reported any event of squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. Metformin 143-152 serpin family B member 3 Homo sapiens 205-208 33346209-9 2020 Conclusion: Application of docetaxel combined with icotinib for chemotherapy of patients with advanced NSCLC can effectively reduce the serum levels of CEA, SCC, and the CA125. icotinib 51-59 serpin family B member 3 Homo sapiens 157-160 33086809-0 2020 Analytical approach to phonon calculations in the SCC-DFTB framework. dftb 54-58 serpin family B member 3 Homo sapiens 50-53 33086809-1 2020 Detailed derivation of the analytical, reciprocal-space approach of Hessian calculation within the self-consistent-charge density-functional based tight-binding framework (SCC-DFTB) is presented. dftb 176-180 serpin family B member 3 Homo sapiens 172-175 33086809-2 2020 This approach provides an accurate and efficient way for obtaining the SCC-DFTB Hessian of periodic systems. dftb 75-79 serpin family B member 3 Homo sapiens 71-74 31800100-3 2020 Pegylated liposomal doxorubicin (PLD) used for maintenance treatment of recurrent high-grade serous cancers has been associated with the development of oral cavity squamous cell carcinoma (SCC). Doxorubicin 20-31 serpin family B member 3 Homo sapiens 189-192 33221175-1 2021 INTRODUCTION: Lung-MAP S1400K was designed to evaluate the response to telisotuzumab vedotin, an antibody-drug conjugate targeting c-MET, in patients with c-MET-positive squamous cell carcinoma (SCC). telisotuzumab vedotin 71-92 serpin family B member 3 Homo sapiens 195-198 33346209-9 2020 Conclusion: Application of docetaxel combined with icotinib for chemotherapy of patients with advanced NSCLC can effectively reduce the serum levels of CEA, SCC, and the CA125. Docetaxel 27-36 serpin family B member 3 Homo sapiens 157-160 32218810-1 2020 The current study investigated the efficacy of podoplanin expression in tumor budding cells as a predictor of neck lymph node metastasis (NLM) in patients with tongue squamous cell carcinoma (SCC) of low tumor budding grade (TBG). podoplanin 47-57 serpin family B member 3 Homo sapiens 192-195 32401271-2 2020 Small studies suggest that voriconazole increases risk of cutaneous squamous cell carcinoma (SCC). Voriconazole 27-39 serpin family B member 3 Homo sapiens 93-96 32401271-13 2020 Compared with lung recipients with no observed voriconazole use, those with 1 to 3 months of voriconazole use experienced increased AHR for SCC of 1.09 (95% CI, 0.90-1.31); 4 to 7 months, 1.42 (95% CI, 1.16-1.73); 8 to 15 months, 2.04 (95% CI, 1.67-2.50); and more than 15 months, 3.05 (95% CI, 2.37-3.91). Voriconazole 93-105 serpin family B member 3 Homo sapiens 140-143 32401271-14 2020 Ever itraconazole exposure was associated with increased SCC risk (AHR, 1.20; 95% CI, 1.00-1.45). Itraconazole 5-17 serpin family B member 3 Homo sapiens 57-60 32401271-16 2020 Conclusions and Relevance: In this study, voriconazole use was associated with increased SCC risk among lung recipients, especially after prolonged exposure. Voriconazole 42-54 serpin family B member 3 Homo sapiens 89-92 32060904-1 2020 BACKGROUND: Voriconazole and genus beta human papillomavirus (HPV) are independently associated with the development of photo-exposed cutaneous squamous cell carcinoma (SCC) but have not been evaluated concurrently. Voriconazole 12-24 serpin family B member 3 Homo sapiens 169-172 32060904-2 2020 The objective of this study is to determine the prevalence and type of detectable HPV DNA in voriconazole-associated SCC. Voriconazole 93-105 serpin family B member 3 Homo sapiens 117-120 32060904-4 2020 An additional expanded PCR analysis of all SCC that developed in the voriconazole group was also performed. Voriconazole 69-81 serpin family B member 3 Homo sapiens 43-46 32060904-7 2020 CONCLUSIONS: In this retrospective study, beta HPV 5, 8, 14, 20, and 21 were commonly detected in voriconazole-associated SCC. Voriconazole 98-110 serpin family B member 3 Homo sapiens 122-125 32696649-3 2020 The present article revisites the ability of the density-functional based tight-binding (SCC-DFTB) approach to model liquids by focusing on liquid water and liquid benzene under ambient conditions. dftb 93-97 serpin family B member 3 Homo sapiens 89-92 32696649-3 2020 The present article revisites the ability of the density-functional based tight-binding (SCC-DFTB) approach to model liquids by focusing on liquid water and liquid benzene under ambient conditions. Water 147-152 serpin family B member 3 Homo sapiens 89-92 32696649-3 2020 The present article revisites the ability of the density-functional based tight-binding (SCC-DFTB) approach to model liquids by focusing on liquid water and liquid benzene under ambient conditions. Benzene 164-171 serpin family B member 3 Homo sapiens 89-92 32696649-4 2020 To do so, we benchmark a recent correction for the SCC-DFTB atomic charges which allows for a drastic improvement of the pair radial distribution functions of liquid water as compared to both experimental data and density functional theory results performed in the generalized-gradient approximation. dftb 55-59 serpin family B member 3 Homo sapiens 51-54 32696649-4 2020 To do so, we benchmark a recent correction for the SCC-DFTB atomic charges which allows for a drastic improvement of the pair radial distribution functions of liquid water as compared to both experimental data and density functional theory results performed in the generalized-gradient approximation. Water 166-171 serpin family B member 3 Homo sapiens 51-54 32696649-6 2020 This allows us to rationalize the impact of nuclear quantum effects on the SCC-DFTB description of liquid water. dftb 79-83 serpin family B member 3 Homo sapiens 75-78 32696649-6 2020 This allows us to rationalize the impact of nuclear quantum effects on the SCC-DFTB description of liquid water. Water 106-111 serpin family B member 3 Homo sapiens 75-78 32696649-7 2020 This study evidences the rather good ability of SCC-DFTB to describe liquid water and liquid benzene. dftb 52-56 serpin family B member 3 Homo sapiens 48-51 32696649-7 2020 This study evidences the rather good ability of SCC-DFTB to describe liquid water and liquid benzene. Water 76-81 serpin family B member 3 Homo sapiens 48-51 32696649-7 2020 This study evidences the rather good ability of SCC-DFTB to describe liquid water and liquid benzene. Benzene 93-100 serpin family B member 3 Homo sapiens 48-51 32829368-1 2020 A 66-year-old man was diagnosed with advanced gastric cancer(L, Less, Type 2, T4a[SE], N2, M1[LYM], H0, P0, cStage IV)and received treatment with S-1/cisplatin as first-line chemotherapy. S-1 146-149 serpin family B member 3 Homo sapiens 78-81 31617906-2 2020 The arginine catabolic mobile element (ACME) is an SCC-like element harbouring an arginine deiminase pathway gene cluster (ACME-arc). Arginine Vasopressin 4-12 serpin family B member 3 Homo sapiens 51-54 31150714-6 2020 SCC was associated with use of carbamazepine (OR 1.88, 95%CI: 1.42 to 2.49) and lamotrigine (OR 1.57, 95%CI: 1.12 to 2.22) with evidence of a dose-response relationship for carbamazepine. Carbamazepine 31-44 serpin family B member 3 Homo sapiens 0-3 31150714-6 2020 SCC was associated with use of carbamazepine (OR 1.88, 95%CI: 1.42 to 2.49) and lamotrigine (OR 1.57, 95%CI: 1.12 to 2.22) with evidence of a dose-response relationship for carbamazepine. Lamotrigine 80-91 serpin family B member 3 Homo sapiens 0-3 31150714-6 2020 SCC was associated with use of carbamazepine (OR 1.88, 95%CI: 1.42 to 2.49) and lamotrigine (OR 1.57, 95%CI: 1.12 to 2.22) with evidence of a dose-response relationship for carbamazepine. Carbamazepine 173-186 serpin family B member 3 Homo sapiens 0-3 31150714-7 2020 The estimated absolute risks were low, e.g. 6335 person-years of high cumulative exposure to carbamazepine were required for one additional SCC to occur. Carbamazepine 93-106 serpin family B member 3 Homo sapiens 140-143 31150714-8 2020 LIMITATIONS: Data on important risk factors for skin cancer, e.g. sun exposure, were not available CONCLUSIONS: Most antiepileptic drugs were not associated with skin cancer, however, carbamazepine and lamotrigine were associated with SCC. Carbamazepine 184-197 serpin family B member 3 Homo sapiens 235-238 32083006-8 2020 Thus, metformin treatment showed combinatorial therapeutic value, which resulted in greater induction of lung SCC apoptosis in vitro and in vivo. Metformin 6-15 serpin family B member 3 Homo sapiens 110-113 32188378-6 2020 We followed the ICG containing liposomal nanoparticle uptake into the squamous carcinoma cells (SCC) under a fluorescence microscopy and into SCC tumor in the nude mice orthotopic xenografts model under a surgical microscope. Indocyanine Green 16-19 serpin family B member 3 Homo sapiens 96-99 32188378-9 2020 The SCC cells showed that the ICG containing liposomes bind to cell surface but are not internalized in the SCC-9 cells in 30 minutes" incubation. Indocyanine Green 30-33 serpin family B member 3 Homo sapiens 4-7 32188378-10 2020 We also showed here that ICG containing liposomal nanoparticles can be traced under a surgical camera in vivo in orthotopic SCC xenografts in mice. Indocyanine Green 25-28 serpin family B member 3 Homo sapiens 124-127 31617906-2 2020 The arginine catabolic mobile element (ACME) is an SCC-like element harbouring an arginine deiminase pathway gene cluster (ACME-arc). Arginine Vasopressin 82-90 serpin family B member 3 Homo sapiens 51-54 31783581-4 2019 In-silica analyses indicate FAT1 mutations are frequent and drive head-neck SCC, with enhanced expression defining high-risk population and poor prognosis. Silicon Dioxide 3-9 serpin family B member 3 Homo sapiens 76-79 31298947-6 2020 High consumption of monounsaturated fat was significantly associated with a decreased risk of BCC (RR: 0.90, 95% CI: 0.85-0.96) and high level of polyunsaturated fat intake was potentially positively associated with SCC (RR: 1.19, 95% CI: 1.06-1.33). polyunsaturated fat 146-165 serpin family B member 3 Homo sapiens 216-219 31746859-1 2019 The present study reports the fabrication of a silver chalcogenolate cluster hybrid membrane (SCC membrane) through self-assembly of SCCs, and then covalent cross-linking of the modified SCC assembled materials. Silver 47-68 serpin family B member 3 Homo sapiens 94-97 31746859-1 2019 The present study reports the fabrication of a silver chalcogenolate cluster hybrid membrane (SCC membrane) through self-assembly of SCCs, and then covalent cross-linking of the modified SCC assembled materials. Silver 47-68 serpin family B member 3 Homo sapiens 133-136 31832423-9 2019 Hematoxylin and eosin staining revealed a moderately differentiated SCC. Hematoxylin 0-11 serpin family B member 3 Homo sapiens 68-71 31832423-9 2019 Hematoxylin and eosin staining revealed a moderately differentiated SCC. Eosine Yellowish-(YS) 16-21 serpin family B member 3 Homo sapiens 68-71 31719553-6 2019 Furthermore, the hydrogen storage capacity of the ScC nanotubes has been explored. Hydrogen 17-25 serpin family B member 3 Homo sapiens 50-53 31599279-6 2019 The latter, chosen for its aggressiveness due to the upregulation of the anti-apoptotic protein SerpinB3, was selectively inhibited in terms of growth by some Au(iii)-DTC complexes. Gold 159-170 serpin family B member 3 Homo sapiens 96-104 31719553-7 2019 The calculated results show that one unit of the (0,3) ScC nanotube can adsorb a maximum of 51 hydrogen molecules, reaching up to a 6.25 wt% hydrogen gravimetric density with an average binding energy of 0.23 eV/H2. Hydrogen 95-103 serpin family B member 3 Homo sapiens 55-58 31719553-7 2019 The calculated results show that one unit of the (0,3) ScC nanotube can adsorb a maximum of 51 hydrogen molecules, reaching up to a 6.25 wt% hydrogen gravimetric density with an average binding energy of 0.23 eV/H2. Hydrogen 141-149 serpin family B member 3 Homo sapiens 55-58 31365038-3 2019 Epidemiologic data on vitamin A intake and risk of cutaneous squamous cell carcinoma (SCC) are limited. Vitamin A 22-31 serpin family B member 3 Homo sapiens 86-89 31365038-4 2019 Objective: To examine whether vitamin A intake is associated with a reduction in SCC risk. Vitamin A 30-39 serpin family B member 3 Homo sapiens 81-84 31365038-17 2019 Conclusions and Relevance: This study suggests that increased intake of dietary vitamin A is associated with decreased risk of incident SCC. Vitamin A 80-89 serpin family B member 3 Homo sapiens 136-139 31365038-18 2019 Future studies are needed to determine whether vitamin A supplementation has a role in chemoprevention of SCC. Vitamin A 47-56 serpin family B member 3 Homo sapiens 106-109 31140754-1 2019 Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved. 5-amino levulinic acid 72-93 serpin family B member 3 Homo sapiens 160-163 31723461-1 2019 Background: The relationship between vitamin D and skin squamous cell carcinoma (SCC) is not well defined. Vitamin D 37-46 serpin family B member 3 Homo sapiens 81-84 31723461-8 2019 In the SCC and control groups, 69.8% and 31.7%, respectively, had sufficient levels of vitamin D (P < 0.001). Vitamin D 87-96 serpin family B member 3 Homo sapiens 7-10 31723461-9 2019 Mean level of 25-hydroxyvitamin D was 40.99 ng/mL in the SCC group and 26.34 ng/mL in the control group (P < 0.05). Calcifediol 14-33 serpin family B member 3 Homo sapiens 57-60 31723461-10 2019 In the unadjusted model, the level of vitamin D as a continuous variable was positively related to SCC risk. Vitamin D 38-47 serpin family B member 3 Homo sapiens 99-102 30920641-2 2019 OBJECTIVES: To examine the association between aspirin and NSAID (nonaspirin) use and the risk of BCC and SCC in a large cohort specifically designed for skin cancer outcomes. Aspirin 47-54 serpin family B member 3 Homo sapiens 106-109 30920641-4 2019 We used Cox proportional hazards models to estimate the hazard ratios (HRs) between self-reported aspirin and NSAID use 1 year prior to study baseline and the first histologically confirmed BCC or SCC for high-risk (history of skin cancer excisions or more than five actinic lesions treated) and average-to-low-risk participants (no history of skin cancer excision and at most five actinic lesions treated). Aspirin 98-105 serpin family B member 3 Homo sapiens 197-200 30920641-7 2019 Aspirin use was associated with reduced risk of SCC (HR 0 77, 95% confidence interval 0 64-0 93) only among infrequent (less than weekly) users and was not associated with BCC. Aspirin 0-7 serpin family B member 3 Homo sapiens 48-51 30659512-6 2019 The results of this study indicated that cadmium levels in dental calculus were significantly higher in male oral SCC patients with betel-quid chewing and smoking than that in healthy individuals without habit of betel-quid chewing and with smoking (p < 0.0001). Cadmium 41-48 serpin family B member 3 Homo sapiens 114-117 30659512-7 2019 This study gives some evidence to support that there may be a positive relationship between cadmium in dental calculus due to betel-quid chewing and risk of oral SCC. Cadmium 92-99 serpin family B member 3 Homo sapiens 162-165 31140754-1 2019 Although having shown promising clinical outcomes, the effectiveness of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) for squamous cell carcinoma (SCC) and glioblastoma remains to be improved. Alanine 122-125 serpin family B member 3 Homo sapiens 160-163 31140754-3 2019 In this in vitro study, the influence of methadone to the effectiveness of ALA-PDT for SCC (FADU) and glioblastoma (A172) was investigated on the protoporphyrin IX (PpIX) fluorescence, survival rates, apoptosis, and cell cycle phase, each with or without the presence of methadone. Methadone 41-50 serpin family B member 3 Homo sapiens 87-90 31140754-3 2019 In this in vitro study, the influence of methadone to the effectiveness of ALA-PDT for SCC (FADU) and glioblastoma (A172) was investigated on the protoporphyrin IX (PpIX) fluorescence, survival rates, apoptosis, and cell cycle phase, each with or without the presence of methadone. Alanine 75-78 serpin family B member 3 Homo sapiens 87-90 31140754-7 2019 This study demonstrates the potential of methadone to influence the cytotoxic effect of ALA-PDT for both SCC and glioblastoma cell lines. Methadone 41-50 serpin family B member 3 Homo sapiens 105-108 31140754-7 2019 This study demonstrates the potential of methadone to influence the cytotoxic effect of ALA-PDT for both SCC and glioblastoma cell lines. Alanine 88-91 serpin family B member 3 Homo sapiens 105-108 31247344-3 2019 SerpinB3 (SPB3) belongs to the ovalbumin-serpin family and is a potent cross-class inhibitor of cysteine cathepsins L, K, S and papain. Cysteine 96-104 serpin family B member 3 Homo sapiens 0-8 31247344-3 2019 SerpinB3 (SPB3) belongs to the ovalbumin-serpin family and is a potent cross-class inhibitor of cysteine cathepsins L, K, S and papain. Cysteine 96-104 serpin family B member 3 Homo sapiens 10-14 31412167-9 2019 CONCLUSIONS: The upregulation of IDO expression in leukocytes and squamous cells in HPV-associated SIL and SCC suggests that immunosuppressive mechanisms involving tryptophan metabolism may have a role in cervical carcinogenesis. Tryptophan 164-174 serpin family B member 3 Homo sapiens 107-110 31309738-1 2019 BACKGROUND: The first-line treatment for squamous cell lung cancer (SCC) has not necessarily been established; however, our previous exploratory study suggested that the combination of nedaplatin and amrubicin would be a promising treatment approach for patients with SCC. nedaplatin 185-195 serpin family B member 3 Homo sapiens 68-71 31309738-1 2019 BACKGROUND: The first-line treatment for squamous cell lung cancer (SCC) has not necessarily been established; however, our previous exploratory study suggested that the combination of nedaplatin and amrubicin would be a promising treatment approach for patients with SCC. nedaplatin 185-195 serpin family B member 3 Homo sapiens 268-271 31309738-1 2019 BACKGROUND: The first-line treatment for squamous cell lung cancer (SCC) has not necessarily been established; however, our previous exploratory study suggested that the combination of nedaplatin and amrubicin would be a promising treatment approach for patients with SCC. amrubicin 200-209 serpin family B member 3 Homo sapiens 68-71 31309738-1 2019 BACKGROUND: The first-line treatment for squamous cell lung cancer (SCC) has not necessarily been established; however, our previous exploratory study suggested that the combination of nedaplatin and amrubicin would be a promising treatment approach for patients with SCC. amrubicin 200-209 serpin family B member 3 Homo sapiens 268-271 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. u-13c 40-45 serpin family B member 3 Homo sapiens 0-3 31358091-4 2019 METHODOLOGY: Paraffin blocks of diagnosed cases of oral SCC presenting at Pathology Department, KEMU, were selected for immunostain GLUT 1. Paraffin 13-21 serpin family B member 3 Homo sapiens 56-59 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. Glucose 47-54 serpin family B member 3 Homo sapiens 0-3 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. Glucose 141-148 serpin family B member 3 Homo sapiens 0-3 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. Glucose 141-148 serpin family B member 3 Homo sapiens 59-62 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. Glutamine 153-162 serpin family B member 3 Homo sapiens 0-3 31114017-6 2019 SCC tumours from patients infused with [U-13C]-glucose and SCC tissue slices incubated with stable isotope tracers demonstrated differential glucose and glutamine catabolism compared to AdCs or non-cancerous lung, confirming increased activity through pathways defined by the SCC metabolic gene signature. Glutamine 153-162 serpin family B member 3 Homo sapiens 59-62 31114017-11 2019 They also highlight potential targets for therapeutic intervention in SCC patients including differentially expressed enzymes that catalyse reactions in glycolysis, glutamine catabolism, serine, nucleotide and glutathione biosynthesis. Glutamine 165-174 serpin family B member 3 Homo sapiens 70-73 31114017-11 2019 They also highlight potential targets for therapeutic intervention in SCC patients including differentially expressed enzymes that catalyse reactions in glycolysis, glutamine catabolism, serine, nucleotide and glutathione biosynthesis. Serine 187-193 serpin family B member 3 Homo sapiens 70-73 31114017-11 2019 They also highlight potential targets for therapeutic intervention in SCC patients including differentially expressed enzymes that catalyse reactions in glycolysis, glutamine catabolism, serine, nucleotide and glutathione biosynthesis. Glutathione 210-221 serpin family B member 3 Homo sapiens 70-73 31184315-10 2019 SERPINB3&4 promote inflammation and impaired skin barrier function in the early stage of atopic dermatitis. Adenosine Monophosphate 9-12 serpin family B member 3 Homo sapiens 0-8 30846478-5 2019 Furthermore, rigosertib significantly inhibited the growth of two RDEB SCC in murine xenograft studies with no apparent toxicity. ON 01910 13-23 serpin family B member 3 Homo sapiens 71-74 30846478-7 2019 Comparison of PLK1 siRNA with MEK inhibition, AKT inhibition, and the microtubule-disrupting agent vinblastine in RDEB SCC shows that only PLK1 reduction exhibits a similar sensitivity profile to rigosertib. Vinblastine 99-110 serpin family B member 3 Homo sapiens 119-122 31097099-17 2019 CONCLUSION: ACC and SCC are the most common MTT. monooxyethylene trimethylolpropane tristearate 44-47 serpin family B member 3 Homo sapiens 20-23 30707342-14 2019 CONCLUSIONS: Analysis of a national tumor registry suggests a lack of overall survival benefit for NAC with localized, muscle invasive SCC of the bladder. nac 99-102 serpin family B member 3 Homo sapiens 135-138 31051467-2 2019 In adrenal glands and gonads, cytochrome P450 side chain cleavage enzyme (SCC or CYP11A1), catalyzes conversion of cholesterol to pregnenolone. Cholesterol 115-126 serpin family B member 3 Homo sapiens 74-77 31183210-5 2019 The increased risk of SCC in transplant patients is due to immunosuppressive therapies, even though everolimus could reduce this risk. Everolimus 100-110 serpin family B member 3 Homo sapiens 22-25 31051467-2 2019 In adrenal glands and gonads, cytochrome P450 side chain cleavage enzyme (SCC or CYP11A1), catalyzes conversion of cholesterol to pregnenolone. Pregnenolone 130-142 serpin family B member 3 Homo sapiens 74-77 30829856-1 2019 We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. f-fluciclovine 109-123 serpin family B member 3 Homo sapiens 60-63 31006210-10 2019 Results of GMDR showed that the best interaction model in both groups of CINII/III and SCC appeared as hnRNP E1 low expression, HPV16 E2 low expression and HPV16 E6 high expression. gmdr 11-15 serpin family B member 3 Homo sapiens 87-90 30552889-9 2019 However, mitomycin was performed in 93.3% and 20.5% of miSCC and SCC, respectively (P < .001). Mitomycin 9-18 serpin family B member 3 Homo sapiens 57-60 30986937-6 2019 MMP2-9 activity was reduced in FFA-treated Huh7 and SCC and cotreatment with Silybin induced a dose-dependent increase, while no effect was observed in LX2. Fatty Acids, Nonesterified 31-34 serpin family B member 3 Homo sapiens 52-55 30986937-6 2019 MMP2-9 activity was reduced in FFA-treated Huh7 and SCC and cotreatment with Silybin induced a dose-dependent increase, while no effect was observed in LX2. Silybin 77-84 serpin family B member 3 Homo sapiens 52-55 30552889-11 2019 SCC received mitomycin in case of tumoral resection margins, respectively (P = .018). Mitomycin 13-22 serpin family B member 3 Homo sapiens 0-3 31933951-5 2019 The differential alterations of the proteins in SCC cell lines SCL12 and COLO16, upon resveratrol therapy, were also examined by immunocytochemistry (ICC). resveratrol 86-97 serpin family B member 3 Homo sapiens 48-51 31933951-7 2019 Additionally, the strong correlation among the proteins with cancer stages implies their distinct roles in SCC pathogenesis and contributions to the therapeutic effects of resveratrol, which is demonstrated in the resveratrol-sensitive COLO16 cells, but not in the resveratrol-resistant SCL12 cells. resveratrol 172-183 serpin family B member 3 Homo sapiens 107-110 31933951-7 2019 Additionally, the strong correlation among the proteins with cancer stages implies their distinct roles in SCC pathogenesis and contributions to the therapeutic effects of resveratrol, which is demonstrated in the resveratrol-sensitive COLO16 cells, but not in the resveratrol-resistant SCL12 cells. resveratrol 214-225 serpin family B member 3 Homo sapiens 107-110 31933951-7 2019 Additionally, the strong correlation among the proteins with cancer stages implies their distinct roles in SCC pathogenesis and contributions to the therapeutic effects of resveratrol, which is demonstrated in the resveratrol-sensitive COLO16 cells, but not in the resveratrol-resistant SCL12 cells. resveratrol 214-225 serpin family B member 3 Homo sapiens 107-110 30866469-8 2019 Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of gamma-aminobutyric acid (GABA). Niacinamide 46-55 serpin family B member 3 Homo sapiens 17-20 30931112-4 2019 Patients suffering from SCC of the pancreas do not respond well to chemotherapy or radiotherapy and isolated reports are available on the use of gemcitabine and newer taxane formulations. taxane 167-173 serpin family B member 3 Homo sapiens 24-27 30931112-6 2019 Herein, a case of SCC of the pancreatic tail is reported in a 60-year-old patient who was managed with a combination of albumin-free nanosomal paclitaxel lipid suspension (NPLS) and gemcitabine in a neoadjuvant setting. paclitaxel lipid 143-159 serpin family B member 3 Homo sapiens 18-21 30931112-6 2019 Herein, a case of SCC of the pancreatic tail is reported in a 60-year-old patient who was managed with a combination of albumin-free nanosomal paclitaxel lipid suspension (NPLS) and gemcitabine in a neoadjuvant setting. gemcitabine 182-193 serpin family B member 3 Homo sapiens 18-21 30866469-8 2019 Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of gamma-aminobutyric acid (GABA). Serotonin 75-84 serpin family B member 3 Homo sapiens 17-20 30849917-0 2019 An efficient way to model complex magnetite: Assessment of SCC-DFTB against DFT. dftb 63-67 serpin family B member 3 Homo sapiens 59-62 30866469-8 2019 Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 104-127 serpin family B member 3 Homo sapiens 17-20 30849917-6 2019 Here, a less computationally demanding DFT-based method, i.e., self-consistent charge density functional tight-binding (SCC-DFTB), is adopted to investigate magnetite bulk and low-index (001) surfaces with newly proposed parameters for Fe-O interactions. dftb 124-128 serpin family B member 3 Homo sapiens 120-123 30849917-7 2019 We report that SCC-DFTB with on-site Coulomb correction provides results in quantitatively comparable agreement with those obtained by DFT + U and hybrid functional methods. dftb 19-23 serpin family B member 3 Homo sapiens 15-18 30866469-8 2019 Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of gamma-aminobutyric acid (GABA). gamma-Aminobutyric Acid 129-133 serpin family B member 3 Homo sapiens 17-20 30849917-8 2019 Therefore, SCC-DFTB is valued as an efficient and reliable method for the description magnetite. dftb 15-19 serpin family B member 3 Homo sapiens 11-14 30316684-1 2019 BACKGROUND: Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. Cisplatin 101-110 serpin family B member 3 Homo sapiens 61-64 30849917-9 2019 This assessment will promote SCC-DFTB computational studies on magnetite-based nanostructures that attract increasing attention for medical applications. dftb 33-37 serpin family B member 3 Homo sapiens 29-32 30316684-1 2019 BACKGROUND: Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. Fluorouracil 115-129 serpin family B member 3 Homo sapiens 61-64 30703319-0 2019 Two-Dimensional Hydroxyl-Functionalized and Carbon-Deficient Scandium Carbide, ScC xOH, a Direct Band Gap Semiconductor. Hydroxyl Radical 16-24 serpin family B member 3 Homo sapiens 79-82 31041280-3 2019 It is a type of waistline SCC reported in Indian males wearing dhoti. dhoti 63-68 serpin family B member 3 Homo sapiens 26-29 30503889-7 2019 RESULTS: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027). nac 52-55 serpin family B member 3 Homo sapiens 23-26 30503889-7 2019 RESULTS: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027). nac 52-55 serpin family B member 3 Homo sapiens 92-95 30503889-11 2019 CONCLUSIONS: In response to NAC, the optimal cutoff percentage of viable tumor for predicting survival differs between ADC and SCC. nac 28-31 serpin family B member 3 Homo sapiens 127-130 30703319-0 2019 Two-Dimensional Hydroxyl-Functionalized and Carbon-Deficient Scandium Carbide, ScC xOH, a Direct Band Gap Semiconductor. Carbon 44-50 serpin family B member 3 Homo sapiens 79-82 30703319-0 2019 Two-Dimensional Hydroxyl-Functionalized and Carbon-Deficient Scandium Carbide, ScC xOH, a Direct Band Gap Semiconductor. scandium carbide 61-77 serpin family B member 3 Homo sapiens 79-82 30703319-4 2019 Here, we demonstrate the fabrication of 2D hydroxyl-functionalized and carbon-deficient scandium carbide, namely, ScC xOH, by selective etching of a layered parent ScAl3C3 compound. 2d hydroxyl 40-51 serpin family B member 3 Homo sapiens 114-117 30703319-4 2019 Here, we demonstrate the fabrication of 2D hydroxyl-functionalized and carbon-deficient scandium carbide, namely, ScC xOH, by selective etching of a layered parent ScAl3C3 compound. Carbon 71-77 serpin family B member 3 Homo sapiens 114-117 30703319-4 2019 Here, we demonstrate the fabrication of 2D hydroxyl-functionalized and carbon-deficient scandium carbide, namely, ScC xOH, by selective etching of a layered parent ScAl3C3 compound. scandium carbide 88-104 serpin family B member 3 Homo sapiens 114-117 30703319-4 2019 Here, we demonstrate the fabrication of 2D hydroxyl-functionalized and carbon-deficient scandium carbide, namely, ScC xOH, by selective etching of a layered parent ScAl3C3 compound. xoh 118-121 serpin family B member 3 Homo sapiens 114-117 30703319-6 2019 Furthermore, this ScC xOH-based device exhibits excellent photoresponse in the ultraviolet-visible light region (responsivity of 0.125 A/W at 360 nm/10 V, and quantum efficiency of 43%). xoh 22-25 serpin family B member 3 Homo sapiens 18-21 30106815-9 2019 In contrast, Ki-67 staining was unevenly intense in SCC. ki-67 13-18 serpin family B member 3 Homo sapiens 52-55 30809524-7 2019 Utilizing a human papillomavirus transgenic mouse model that develops cutaneous SCC in response to ultraviolet irradiation we identified tumor uptake of PA in vivo. Protactinium 153-155 serpin family B member 3 Homo sapiens 80-83 30809524-11 2019 These results suggest that PA could be systemically administered for rapid identification of cutaneous SCC, with potential for further therapeutic development. Protactinium 27-29 serpin family B member 3 Homo sapiens 103-106 30445228-8 2019 The lowest risk was observed for persons who consumed 10-19.9 g/day ethanol (OR vs. non-drinkers = 0.78; 95% CI: 0.67, 0.91), where 1 drink is approximately 12-15 g. This J-shaped association was most prominent for squamous cell carcinoma (SCC). Ethanol 68-75 serpin family B member 3 Homo sapiens 240-243 30761272-3 2019 Expression of a specific carbohydrate ligand for the immune-regulatory C-type lectin MGL was correlated to poor disease-specific survival and distant recurrences in squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC), the most common histological subtypes of cervical cancer. Carbohydrates 25-37 serpin family B member 3 Homo sapiens 190-193 31282406-9 2019 The cut-off value of TMI based on SCC and CYFRA 21-1 was 0.531, and the patients were subdivided into high and low TMI groups. phospho-tyrosol-indomethacin 21-24 serpin family B member 3 Homo sapiens 34-37 30895944-1 2019 BACKGROUND: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). calcipotriene 20-32 serpin family B member 3 Homo sapiens 183-186 30895944-1 2019 BACKGROUND: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). Fluorouracil 38-52 serpin family B member 3 Homo sapiens 183-186 30895944-1 2019 BACKGROUND: Topical calcipotriol plus 5-fluorouracil (5-FU) combination is an effective immunotherapy against actinic keratosis (AK), which is a precursor to squamous cell carcinoma (SCC). Fluorouracil 54-58 serpin family B member 3 Homo sapiens 183-186 30895944-2 2019 However, the long-term effectiveness of calcipotriol plus 5-FU treatment for SCC prevention is unknown. calcipotriene 40-52 serpin family B member 3 Homo sapiens 77-80 30895944-10 2019 CONCLUSION: A short course of calcipotriol plus 5-FU treatment on the face and scalp is associated with induction of robust T cell immunity and Trm formation against AKs and significantly lowers the risk of SCC development within 3 years of treatment. calcipotriene 30-42 serpin family B member 3 Homo sapiens 207-210 30895944-10 2019 CONCLUSION: A short course of calcipotriol plus 5-FU treatment on the face and scalp is associated with induction of robust T cell immunity and Trm formation against AKs and significantly lowers the risk of SCC development within 3 years of treatment. Fluorouracil 48-52 serpin family B member 3 Homo sapiens 207-210 30525920-1 2019 OBJECTIVES:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation. potassium titanylphosphate 136-163 serpin family B member 3 Homo sapiens 126-129 30525920-1 2019 OBJECTIVES:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation. KTP compound 165-168 serpin family B member 3 Homo sapiens 126-129 30717317-4 2019 Here, we assessed the relationship between miR-122 and SerpinB3 and their influence on cell phenotype and sorafenib resistance in HCC. Sorafenib 106-115 serpin family B member 3 Homo sapiens 55-63 30348838-3 2019 Cytochrome P450 side-chain cleavage enzyme (SCC or CYP11A1) catalyzes cholesterol to pregnenolone conversion, although its mechanism of action is not well understood. Cholesterol 70-81 serpin family B member 3 Homo sapiens 44-47 30348838-3 2019 Cytochrome P450 side-chain cleavage enzyme (SCC or CYP11A1) catalyzes cholesterol to pregnenolone conversion, although its mechanism of action is not well understood. Pregnenolone 85-97 serpin family B member 3 Homo sapiens 44-47 30515999-4 2018 This was an explorative study to determine the mechanism of honokiol in lung SCC. honokiol 60-68 serpin family B member 3 Homo sapiens 77-80 30515999-5 2018 We found that honokiol induced apoptosis and cell cycle arrest in lung SCC cell lines in a time- and dose-dependent manner. honokiol 14-22 serpin family B member 3 Homo sapiens 71-74 30515999-6 2018 Honokiol also restricted cell migration in lung SCC cell lines. honokiol 0-8 serpin family B member 3 Homo sapiens 48-51 30515999-10 2018 In conclusion, honokiol induced cell apoptosis in lung SCC by targeting the FGF2-FGFR1 autocrine loop. honokiol 15-23 serpin family B member 3 Homo sapiens 55-58 30101911-1 2018 Squamous cell carcinoma (SCC) transformation has been identified as a mechanism of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), gefitinib or erlotinib, in EGFR-mutated lung cancer. Gefitinib 187-196 serpin family B member 3 Homo sapiens 25-28 30101911-1 2018 Squamous cell carcinoma (SCC) transformation has been identified as a mechanism of resistance to first-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), gefitinib or erlotinib, in EGFR-mutated lung cancer. Erlotinib Hydrochloride 200-209 serpin family B member 3 Homo sapiens 25-28 30101911-3 2018 We herein report an EGFR-mutated lung adenocarcinoma undergoing transformation into SCC that exhibited a durable response to afatinib, which is a second-generation irreversible EGFR-TKI. Afatinib 125-133 serpin family B member 3 Homo sapiens 84-87 30101911-4 2018 We suggest that afatinib can be considered as a treatment option for EGFR-mutated tumor undergoing SCC transformation, particularly in the absence of a T790M mutation. Afatinib 16-24 serpin family B member 3 Homo sapiens 99-102 30419851-6 2018 RESULTS: In the entire cohort, 5y Disease Specific Survival (DSS) was 97.1 and 84% for AC and SCC respectively (p = 0.150). dss 61-64 serpin family B member 3 Homo sapiens 94-97 30419851-7 2018 In the NA-CRT group 5y DSS was 100 and 75.5% for AC and SCC respectively (p = 0.059). dss 23-26 serpin family B member 3 Homo sapiens 56-59 30222205-5 2018 8-OHdG was significantly overexpressed in AK and BD lesions compared with surrounding non-lesional tissue, SCC lesions and the healthy controls. 8-ohdg 0-6 serpin family B member 3 Homo sapiens 107-110 30222205-6 2018 DT was more highly expressed in AK, BD and SCC than in the controls. dityrosine 0-2 serpin family B member 3 Homo sapiens 43-46 29567334-1 2018 OBJECTIVE: Recent data indicated that concurrent chemoradiotherapy (CCRT) using high dose cisplatin (CDDP) is the most useful treatment for advanced head and neck squamous cell carcinoma (SCC). Cisplatin 90-99 serpin family B member 3 Homo sapiens 188-191 30349346-1 2018 Background: Photosensitizing diuretics use (especially thiazide compounds) is associated with a significantly higher risk of squamous cell carcinoma (SCC). Thiazides 55-63 serpin family B member 3 Homo sapiens 150-153 29779859-8 2018 We have tried to collect other cases in the literature and in pharmacovigilance centres: three similar cases were recently published in the literature, 21 cases were notified to the European Medicines Agency and we asked French pharmacovigilance centres and found 5 cases of SCC after ingenol mebutate application. 3-ingenyl angelate 285-301 serpin family B member 3 Homo sapiens 275-278 29567334-1 2018 OBJECTIVE: Recent data indicated that concurrent chemoradiotherapy (CCRT) using high dose cisplatin (CDDP) is the most useful treatment for advanced head and neck squamous cell carcinoma (SCC). Cisplatin 101-105 serpin family B member 3 Homo sapiens 188-191 29567334-4 2018 In this multicenter phase I/II study, we aimed to identify the optimal dose of CDDP in CCRT for patients with advanced head and neck SCC in the Japanese. Cisplatin 79-83 serpin family B member 3 Homo sapiens 133-136 30133252-5 2018 This Account summarizes the prevailing strategies used in recent years in the preparation of SCC-based HASs and illustrates how the combination of dynamic metal-ligand coordination with other interactions was used to obtain hierarchical systems with interesting properties. hass 103-107 serpin family B member 3 Homo sapiens 93-96 29423536-6 2018 RESULTS: Multivariate analyses revealed that inactive heterozygous ALDH2 [hazard ratio (HR) 2.25] and alcohol consumption after ER (HR 1.94) were independently associated with the risk of developing secondary SCC. Alcohols 102-109 serpin family B member 3 Homo sapiens 209-212 29423536-7 2018 Moreover, inactive heterozygous ALDH2 (HR 4.39) and alcohol consumption after the ER (HR 2.82) were independently associated with the risk of a third SCC. Alcohols 52-59 serpin family B member 3 Homo sapiens 150-153 29423536-12 2018 CONCLUSIONS: Continued alcohol consumption is an important risk factor for the onset of metachronous SCC and is a risk factor for the third and subsequent SCCs. Alcohols 23-30 serpin family B member 3 Homo sapiens 101-104 30655923-1 2018 Purpose: This study aimed to compare squamous cell carcinoma (SCC) with inflammatory diseases of the oral and maxillofacial region using gallium 67 (67Ga) scintigraphy with computed tomography (CT) and magnetic resonance imaging (MRI). Gallium-67 137-147 serpin family B member 3 Homo sapiens 62-65 30533339-3 2018 Here, we report an unusual case of implant-associated SCC of the breast post silicone gel breast implant. Silicones 77-85 serpin family B member 3 Homo sapiens 54-57 30133252-5 2018 This Account summarizes the prevailing strategies used in recent years in the preparation of SCC-based HASs and illustrates how the combination of dynamic metal-ligand coordination with other interactions was used to obtain hierarchical systems with interesting properties. Metals 155-160 serpin family B member 3 Homo sapiens 93-96 30133252-9 2018 Furthermore, the interplay between the hydrophilic and lipophilic characters of HASs by varying the number and spacial orientation of alkyl/oxyethylene chains of the SCC is a simple yet controllable approach to prepare ordered and tunable nanostructures. alkyl/oxyethylene 134-151 serpin family B member 3 Homo sapiens 166-169 30109777-2 2018 In this study, the efficacy of icotinib in unselected and EGFR-mutated patients with lung SCC was assessed. icotinib 31-39 serpin family B member 3 Homo sapiens 90-93 30109777-3 2018 METHODS: We retrospectively analyzed the survival time of unselected advanced lung SCC patients treated with icotinib for at least 5 months between June 2013 and June 2016, and selected appropriate EGFR-mutated advanced lung ADC patients to have 1:1 ratio of propensity score matching with EGFR-mutated advanced lung SCC patients, and matching factors were age, sex, clinical stage, Karnofsky performance status (KPS), smoking history, EGFR mutation type, and treatment lines. icotinib 109-117 serpin family B member 3 Homo sapiens 83-86 30109777-8 2018 CONCLUSION: Icotinib has a modest therapeutic effect in patients with advanced lung SCC, especially for the population with EGFR mutations. icotinib 12-20 serpin family B member 3 Homo sapiens 84-87 30150430-7 2018 RESULTS: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells. FLJ 14-17 serpin family B member 3 Homo sapiens 97-100 30211303-4 2018 The lateral margin of the SCC was identified by spraying with Lugol"s iodine, and the tumor was resected en bloc with no complications. Lugol's solution 62-76 serpin family B member 3 Homo sapiens 26-29 29995203-1 2018 The first and rate-limited step of steroidogenesis in all steroidogenic tissues is the conversion of cholesterol to pregnenolone, catalysed by P450scc side-chain cleavage enzyme (CYP11A1 gene-SCC). Cholesterol 101-112 serpin family B member 3 Homo sapiens 192-195 29995203-1 2018 The first and rate-limited step of steroidogenesis in all steroidogenic tissues is the conversion of cholesterol to pregnenolone, catalysed by P450scc side-chain cleavage enzyme (CYP11A1 gene-SCC). Pregnenolone 116-128 serpin family B member 3 Homo sapiens 192-195 30150430-7 2018 RESULTS: Both FLJ and curcumin significantly reduced the proliferation and invasion of HSC-3 and SCC-25 cells. Curcumin 22-30 serpin family B member 3 Homo sapiens 97-100 30125310-6 2018 Plasma norepinephrine and epinephrine concentrations were significantly higher in patients with oral and oropharyngeal squamous cell carcinoma (SCC) compared to non-cancer patients. Norepinephrine 7-21 serpin family B member 3 Homo sapiens 144-147 30134727-1 2018 Scandium monocarbide molecules, ScC, have been prepared by the reaction of 532 nm laser-ablated Sc metal with acetylene or methane under supersonic jet-cooled conditions. scandium monocarbide 0-20 serpin family B member 3 Homo sapiens 32-35 30134727-1 2018 Scandium monocarbide molecules, ScC, have been prepared by the reaction of 532 nm laser-ablated Sc metal with acetylene or methane under supersonic jet-cooled conditions. Metals 99-104 serpin family B member 3 Homo sapiens 32-35 30134727-1 2018 Scandium monocarbide molecules, ScC, have been prepared by the reaction of 532 nm laser-ablated Sc metal with acetylene or methane under supersonic jet-cooled conditions. Acetylene 110-119 serpin family B member 3 Homo sapiens 32-35 30125310-6 2018 Plasma norepinephrine and epinephrine concentrations were significantly higher in patients with oral and oropharyngeal squamous cell carcinoma (SCC) compared to non-cancer patients. Epinephrine 10-21 serpin family B member 3 Homo sapiens 144-147 30125310-7 2018 Oral SCC patients displayed plasma norepinephrine levels about six times higher than oropharyngeal SCC patients, and nine times higher than oral leukoplakia patients (p < .001). Norepinephrine 35-49 serpin family B member 3 Homo sapiens 5-8 30134727-1 2018 Scandium monocarbide molecules, ScC, have been prepared by the reaction of 532 nm laser-ablated Sc metal with acetylene or methane under supersonic jet-cooled conditions. Methane 123-130 serpin family B member 3 Homo sapiens 32-35 30125310-8 2018 Plasma epinephrine levels in oral SCC patients were higher compared to the oropharyngeal SCC (p = .0097) and leukoplakia (p < .0001) patients. Epinephrine 7-18 serpin family B member 3 Homo sapiens 34-37 30125310-9 2018 Oropharyngeal SCC patients had higher plasma norepinephrine (p = .0382) and epinephrine levels (p = .045) than patients with oral leukoplakia. Norepinephrine 45-59 serpin family B member 3 Homo sapiens 14-17 30125310-9 2018 Oropharyngeal SCC patients had higher plasma norepinephrine (p = .0382) and epinephrine levels (p = .045) than patients with oral leukoplakia. Epinephrine 48-59 serpin family B member 3 Homo sapiens 14-17 30125310-10 2018 Multiple regression analyses showed that a history of high alcohol consumption was predictive for reduced plasma norepinephrine levels in the oral SCC group (p < .001). Alcohols 59-66 serpin family B member 3 Homo sapiens 147-150 30125310-10 2018 Multiple regression analyses showed that a history of high alcohol consumption was predictive for reduced plasma norepinephrine levels in the oral SCC group (p < .001). Norepinephrine 113-127 serpin family B member 3 Homo sapiens 147-150 30125310-11 2018 Anxiety symptom of "hand tremor" measured by the BAI was an independent predictor for higher plasma norepinephrine levels in HNSCC patients (beta = 157.5, p = .0377), while the "heart pounding/racing" symptom was independently associated with higher plasma epinephrine levels in the oropharyngeal SCC group (beta = 15.8, p = .0441). Norepinephrine 100-114 serpin family B member 3 Homo sapiens 127-130 30125310-11 2018 Anxiety symptom of "hand tremor" measured by the BAI was an independent predictor for higher plasma norepinephrine levels in HNSCC patients (beta = 157.5, p = .0377), while the "heart pounding/racing" symptom was independently associated with higher plasma epinephrine levels in the oropharyngeal SCC group (beta = 15.8, p = .0441). Epinephrine 103-114 serpin family B member 3 Homo sapiens 127-130 30105253-7 2018 We found that P16INK4a positive expression was significantly associated with a better CSS of penile SCC (HR=0.45, 95%CI: 0.30-0.67, P<0.001). thiocysteine 86-89 serpin family B member 3 Homo sapiens 100-103 30211061-4 2018 A total of 126 cases of UDC in women have been reported; 75% adenocarcinoma (Adenoca), 15% transitional cell carcinoma (TCC) and 10% squamous cell carcinoma (SCC). sarcoursodeoxycholic acid 24-27 serpin family B member 3 Homo sapiens 158-161 30025476-7 2018 Expert opinion: Necitumumab plus cisplatin-gemcitabine is a first-line treatment option in SCC that improves overall survival and preserves the patient"s quality of life with a manageable toxicity profile. Cisplatin 33-42 serpin family B member 3 Homo sapiens 91-94 30025476-7 2018 Expert opinion: Necitumumab plus cisplatin-gemcitabine is a first-line treatment option in SCC that improves overall survival and preserves the patient"s quality of life with a manageable toxicity profile. gemcitabine 43-54 serpin family B member 3 Homo sapiens 91-94 29808911-11 2018 Having a previous SCC appeared associated with not being vitamin D deficient (OR = 0.46, 95%CI = 0.20-1.11, P = 0.084). Vitamin D 57-66 serpin family B member 3 Homo sapiens 18-21 30105253-10 2018 Conclusions: P16INK4a positive expression is independently associated with improved CSS for patients with penile SCC. thiocysteine 84-87 serpin family B member 3 Homo sapiens 113-116 29735662-6 2018 Notably as well, higher levels of Stxbp4 expression are correlated with the accumulation of DeltaNp63 in human squamous cell carcinoma (SCC). deltanp63 92-101 serpin family B member 3 Homo sapiens 136-139 30038504-3 2018 In this report, we present a 69-year-old Chinese man with locally advanced EGFR- and ALK-negative lung SCC, who received apatinib after failure of 2 treatment regimens. apatinib 121-129 serpin family B member 3 Homo sapiens 103-106 30038504-6 2018 Apatinib provides an additional option for salvage treatment of lung SCC without driver gene mutations, but further large-scale clinical studies are still warranted. apatinib 0-8 serpin family B member 3 Homo sapiens 69-72 30407159-5 2018 A barium swallow confirmed Zenker"s pouch, the patient underwent diver-ticulectomy and cricopharyngeal myotomy; a histopathological examination of the specimen revealed a fungating mass of SCC within the pouch. Barium 2-8 serpin family B member 3 Homo sapiens 189-192 29904586-7 2018 There is limited direct evidence to show that systemic acitretin or nicotinamide can decrease incident SCC in patients with field cancerization. Acitretin 55-64 serpin family B member 3 Homo sapiens 103-106 29904586-7 2018 There is limited direct evidence to show that systemic acitretin or nicotinamide can decrease incident SCC in patients with field cancerization. Niacinamide 68-80 serpin family B member 3 Homo sapiens 103-106 29636341-7 2018 Higher polyunsaturated fat intake was associated with risk of SCC [pooled HR for highest vs. lowest quintiles, 1.16; 95% confidence interval (CI), 1.05-1.28; Ptrend=0.001] and BCC (pooled HR, 1.06; 95% CI, 1.01-1.11; Ptrend=0.01). polyunsaturated fat 7-26 serpin family B member 3 Homo sapiens 62-65 29636341-8 2018 Higher omega-6 fat intake was associated with risks of SCC, BCC, and melanoma. omega-6 fat 7-18 serpin family B member 3 Homo sapiens 55-58 28739190-3 2018 In this study, we investigated the characteristics and outcomes of patients with SCC of the thyroid, and reported our experience with chemotherapy with lenvatinib in the treatment of SCC of the thyroid. lenvatinib 152-162 serpin family B member 3 Homo sapiens 183-186 28739190-9 2018 Four patients started on oral lenvatinib due to recurrent or progressive SCC of the thyroid. lenvatinib 30-40 serpin family B member 3 Homo sapiens 73-76 29327784-2 2018 METHODS: Three hundred fourteen patients undergoing TORS +- adjuvant therapy for oropharyngeal SCC from May 1, 2007, to May 31, 2015, are analyzed. tors + 52-58 serpin family B member 3 Homo sapiens 95-98 29524519-7 2018 Cell lines over-expressing SerpinB3 displayed upregulation of DPPIV/CD26, likely as a feedback mechanism, due to the DPPIV/CD26 protease activity inhibition by SerpinB3, as confirmed by the similar behavior induced by the inhibitor Sitagliptin. Sitagliptin Phosphate 232-243 serpin family B member 3 Homo sapiens 27-35 29718881-4 2018 PATIENT CONCERNS: Here we reported a 41-year-old man with EGFR-mutated lung adenocarcinoma and he showed histologic transformation to both small-cell lung cancer (SCLC) and squamous cell carcinoma (SCC) after treatment of gefitinib. Gefitinib 222-231 serpin family B member 3 Homo sapiens 198-201 29718881-10 2018 LESSONS: To the best of our knowledge, it is the first case of EGFR-mutated lung adenocarcinoma transforming to both SCLC and SCC which was treated with and responded to gefitinib. Gefitinib 170-179 serpin family B member 3 Homo sapiens 126-129 29692756-17 2018 The extent of SCC and otolith impairment was disease-dependent, showing most extensive damage in BVL related to inner-ear infection and aminoglycoside-exposure and more selective impairment in Meniere"s disease. Aminoglycosides 136-150 serpin family B member 3 Homo sapiens 14-17 29776933-3 2018 This report highlights a case of PCEO in a 75-year-old man with a history of squamous cell carcinoma (SCC) of the scalp. tetrachloroepoxyethane 33-37 serpin family B member 3 Homo sapiens 102-105 29555332-9 2018 The DSS, DFS and OS were significantly better in HPV-related than in non HPV-related vulvar SCC patients. dss 4-7 serpin family B member 3 Homo sapiens 92-95 29239261-6 2018 TBSS results demonstrated focally lower intra-axonal diffusivity (Daxon) in mTBI patients in the splenium of the corpus callosum (sCC; p < 0.05, FWE-corrected). tbss 0-4 serpin family B member 3 Homo sapiens 130-133 29244238-8 2018 CONCLUSION: The TORS-based approach was associated with superior survival in patients with HPV-negative oropharyngeal SCC; similar difference was not observed in patients with HPV-positive disease. tors 16-20 serpin family B member 3 Homo sapiens 118-121 29795720-1 2018 The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). Ruthenium 46-55 serpin family B member 3 Homo sapiens 188-191 29795720-5 2018 We advocate the use of ruthenium brachytherapy as an eye salvage treatment with an intraocular extension of conjunctival SCC. Ruthenium 23-32 serpin family B member 3 Homo sapiens 121-124 29571988-10 2018 MiR-192 and miR-662 inhibition sensitized SCC cells to etoposide but not to cisplatin. Etoposide 55-64 serpin family B member 3 Homo sapiens 42-45 29217346-2 2018 OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Hydrochlorothiazide 46-65 serpin family B member 3 Homo sapiens 142-145 29217346-6 2018 Using conditional logistic regression, we calculated odds ratios (ORs) for BCC and SCC associated with hydrochlorothiazide use. Hydrochlorothiazide 103-122 serpin family B member 3 Homo sapiens 83-86 29217346-7 2018 RESULTS: High use of hydrochlorothiazide (>=50,000 mg) was associated with ORs of 1.29 (95% confidence interval [CI], 1.23-1.35) for BCC and 3.98 (95% CI, 3.68-4.31) for SCC. Hydrochlorothiazide 21-40 serpin family B member 3 Homo sapiens 173-176 29217346-8 2018 We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (>=200,000 mg of HCTZ) had ORs of 1.54 (95% CI, 1.38-1.71) and 7.38 (95% CI, 6.32-8.60) for BCC and SCC, respectively. Hydrochlorothiazide 51-70 serpin family B member 3 Homo sapiens 92-95 29217346-8 2018 We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (>=200,000 mg of HCTZ) had ORs of 1.54 (95% CI, 1.38-1.71) and 7.38 (95% CI, 6.32-8.60) for BCC and SCC, respectively. Hydrochlorothiazide 51-70 serpin family B member 3 Homo sapiens 237-240 29217346-8 2018 We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (>=200,000 mg of HCTZ) had ORs of 1.54 (95% CI, 1.38-1.71) and 7.38 (95% CI, 6.32-8.60) for BCC and SCC, respectively. Hydrochlorothiazide 154-158 serpin family B member 3 Homo sapiens 92-95 29217346-8 2018 We found clear dose-response relationships between hydrochlorothiazide use and both BCC and SCC; the highest cumulative dose category (>=200,000 mg of HCTZ) had ORs of 1.54 (95% CI, 1.38-1.71) and 7.38 (95% CI, 6.32-8.60) for BCC and SCC, respectively. Hydrochlorothiazide 154-158 serpin family B member 3 Homo sapiens 237-240 29217346-11 2018 CONCLUSIONS: Hydrochlorothiazide use is associated with a substantially increased risk of NMSC, especially SCC. Hydrochlorothiazide 13-32 serpin family B member 3 Homo sapiens 107-110 29078250-8 2018 RESULTS: Initial PCA score and loading plots showed clear separation of SCC and normal epithelial tissue using DESI-MS. PCA-LDA resulted in accuracy rates of 95% for SCC versus normal and 93% for SCC, adjacent normal and normal. pca-lda 120-127 serpin family B member 3 Homo sapiens 72-75 29602886-2 2018 The SCC lesions began to develop within 12-15 months after beginning the arsenic-containing TM. Arsenic 73-80 serpin family B member 3 Homo sapiens 4-7 29540708-6 2018 The ratio between the ASR of AC and SCC was strongly correlated with HDI (r = 0.535 [men]; r = 0.661 [women]) and GDP (r = 0.594 [men]; r = 0.550 [women], both p < 0.001). Guanosine Diphosphate 114-117 serpin family B member 3 Homo sapiens 36-39 29130565-1 2018 BACKGROUND: We are currently undertaking a multi-institutional prospective trial of the superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy for patients with T4aN0M0 or T4bN0M0 locally advanced maxillary sinus squamous cell carcinomas (SCC). Cisplatin 140-149 serpin family B member 3 Homo sapiens 276-279 29130565-8 2018 CONCLUSION: These results indicated that this therapy is safe and well-tolerated at 7 cycles of cisplatin, which was determined to be the recommended number of cycles for locally advanced maxillary sinus SCC. Cisplatin 96-105 serpin family B member 3 Homo sapiens 204-207 29198764-1 2018 OBJECTIVE: To assess the effect of photodynamic therapy (PDT) with talaporfin sodium, a second-generation photosensitizer, on oral squamous cell carcinoma (SCC). Talaporfin 67-84 serpin family B member 3 Homo sapiens 156-159 29198764-2 2018 METHODS: Eight patients who were diagnosed with oral SCC without any metastasis and underwent talaporfin sodium-mediated PDT (t-PDT) were included in this study. Talaporfin 94-111 serpin family B member 3 Homo sapiens 53-56 29713579-2 2018 Human papillomavirus (HPV) has been linked with H&N cancer and HPV-positive H&N SCC have been shown to have better survival outcomes. Adenosine Monophosphate 82-85 serpin family B member 3 Homo sapiens 88-91 29744229-2 2018 Herein, we report a case of squamous cell carcinoma (SCC) with ALK rearrangement treated with alectinib. alectinib 94-103 serpin family B member 3 Homo sapiens 53-56 29506549-4 2018 We designed our epidemiological study to isolate lipid levels and profiles by genotype in Guadeloupian cohorts of SCA and SCC adult patients, at steady state. guadeloupian 90-102 serpin family B member 3 Homo sapiens 122-125 29506549-13 2018 CONCLUSIONS: This study reveals that SCA and SCC patients exhibit distinct lipid profiles and suggests that high TG and Non HDL-C levels are associated with past histories of ACS and osteonecrosis in SCA and SCC patients, respectively. Triglycerides 113-115 serpin family B member 3 Homo sapiens 45-48 29506549-13 2018 CONCLUSIONS: This study reveals that SCA and SCC patients exhibit distinct lipid profiles and suggests that high TG and Non HDL-C levels are associated with past histories of ACS and osteonecrosis in SCA and SCC patients, respectively. Triglycerides 113-115 serpin family B member 3 Homo sapiens 208-211 29078250-8 2018 RESULTS: Initial PCA score and loading plots showed clear separation of SCC and normal epithelial tissue using DESI-MS. PCA-LDA resulted in accuracy rates of 95% for SCC versus normal and 93% for SCC, adjacent normal and normal. pca-lda 120-127 serpin family B member 3 Homo sapiens 166-169 29078250-8 2018 RESULTS: Initial PCA score and loading plots showed clear separation of SCC and normal epithelial tissue using DESI-MS. PCA-LDA resulted in accuracy rates of 95% for SCC versus normal and 93% for SCC, adjacent normal and normal. pca-lda 120-127 serpin family B member 3 Homo sapiens 166-169 28898527-1 2018 This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. Voriconazole 53-65 serpin family B member 3 Homo sapiens 113-116 29483993-3 2018 The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression. Alcohols 101-108 serpin family B member 3 Homo sapiens 30-33 29325590-6 2018 Nonsignificant 18F-BPA TNR and TBR changes were seen in patients with SCC and MM. tbr 31-34 serpin family B member 3 Homo sapiens 70-73 29325590-7 2018 CONCLUSIONS: Dynamic changes in SUVmax for 18F-BPA uptake had a washout pattern in SCC and a persistent pattern in MM. 18f-bpa 43-50 serpin family B member 3 Homo sapiens 83-86 28898527-3 2018 Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Voriconazole 58-70 serpin family B member 3 Homo sapiens 170-173 28898527-3 2018 Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Azoles 81-87 serpin family B member 3 Homo sapiens 170-173 28898527-6 2018 In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Voriconazole 138-150 serpin family B member 3 Homo sapiens 256-259 28898527-7 2018 Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Voriconazole 12-24 serpin family B member 3 Homo sapiens 63-66 29073637-7 2018 However, we observed positive interactions between tetracycline use and adulthood UV exposure on SCC risk (P-interaction=0.05). Tetracycline 51-63 serpin family B member 3 Homo sapiens 97-100 28960661-8 2018 CONCLUSIONS: Prophylactic PTND is indicated in laryngeal SCC with anterior subglottic extension and/or posterior subglottis involvement with clinically apparent laterocervical node metastases. ptnd 26-30 serpin family B member 3 Homo sapiens 57-60 28929221-12 2017 In conclusion, our results showed a high level of overall DSS (96%) for patients affected by T1b glottic SCC. dss 58-61 serpin family B member 3 Homo sapiens 105-108 28935635-7 2018 Hemin promoted induction of SerpinB3 mRNA in HeLa and HA22T/VGH cells, but a mild stimulation of SerpinB3 promoter activity in HeLa and Huh7 cells. Hemin 0-5 serpin family B member 3 Homo sapiens 28-36 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. Paclitaxel 148-158 serpin family B member 3 Homo sapiens 93-96 28951130-7 2017 Additionally, the CDC25A inhibitors Vitamin K3 or NSC663284 were more toxic to SCC than normal keratinocytes, and CDC25A inhibition effectively suppressed skin cancer growth by increasing apoptosis without affecting normal skin biology. Vitamin K 3 36-46 serpin family B member 3 Homo sapiens 79-82 28951130-7 2017 Additionally, the CDC25A inhibitors Vitamin K3 or NSC663284 were more toxic to SCC than normal keratinocytes, and CDC25A inhibition effectively suppressed skin cancer growth by increasing apoptosis without affecting normal skin biology. NSC 663284 50-59 serpin family B member 3 Homo sapiens 79-82 29147823-1 2017 BACKGROUND: Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. Alcohols 129-136 serpin family B member 3 Homo sapiens 65-68 28916653-2 2017 Screening a small-molecule library, we identified digitoxin as a high potency compound for suppressing human lung SCC growth in vitro and in vivo Mechanistic investigations revealed that digitoxin attenuated YAP phosphorylation and promoted YAP nuclear sequestration. Digitoxin 50-59 serpin family B member 3 Homo sapiens 114-117 28916653-2 2017 Screening a small-molecule library, we identified digitoxin as a high potency compound for suppressing human lung SCC growth in vitro and in vivo Mechanistic investigations revealed that digitoxin attenuated YAP phosphorylation and promoted YAP nuclear sequestration. Digitoxin 187-196 serpin family B member 3 Homo sapiens 114-117 28916653-4 2017 In patient-derived xenograft models, digitoxin treatment efficiently inhibited lung SCC progression in correlation with reduced expression of YAP. Digitoxin 37-46 serpin family B member 3 Homo sapiens 84-87 28741159-8 2017 CKpan, EMA and Cam5.2 showed strong positive immunoreactivity in all specimens (SGC, BCC, SCC). ckpan 0-5 serpin family B member 3 Homo sapiens 90-93 30512606-7 2017 There are forms of SCC in situ or Bowen disease, cutaneous or mucosal, accessible to cryotherapy, 5-FU, imiquimod or dynamic phototherapy as an alternative to surgery. Fluorouracil 98-102 serpin family B member 3 Homo sapiens 19-22 28766013-2 2017 The aim of this study is to explore if metal arc welding increases the risk of malignant melanoma and/or basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) on skin areas which may possibly be exposed (neck, head, and upper extremities). Metals 39-44 serpin family B member 3 Homo sapiens 161-164 29027399-7 2017 For SCC and AC, the 10-year CSS rates were 93.4% and 94.7%, respectively (p=0.011), and the 10-year OS rates were 89.6% and 92.2%, respectively (p<0.001). thiocysteine 28-31 serpin family B member 3 Homo sapiens 4-7 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. Carboplatin 173-184 serpin family B member 3 Homo sapiens 93-96 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. dd-tc 186-191 serpin family B member 3 Homo sapiens 93-96 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. Irinotecan 232-242 serpin family B member 3 Homo sapiens 93-96 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. Cisplatin 247-256 serpin family B member 3 Homo sapiens 93-96 29184868-1 2017 We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. cpt-p 258-263 serpin family B member 3 Homo sapiens 93-96 28691255-4 2017 RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). dss 177-180 serpin family B member 3 Homo sapiens 148-151 28984139-6 2017 Here, we describe a case an older gentleman with a history of SCC with PNI successfully treated with erlotinib and intrathecal chemotherapy. Erlotinib Hydrochloride 101-110 serpin family B member 3 Homo sapiens 62-65 29142391-2 2017 Objective: We evaluated the cytotoxic activity of ethanol extract of A. catechu seed (ACS) against SCC-25 human oral squamous carcinoma cell line. Ethanol 50-57 serpin family B member 3 Homo sapiens 99-102 28691255-4 2017 RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). dss 73-76 serpin family B member 3 Homo sapiens 148-151 29323067-5 2017 RESULTS AND CONCLUSION: In SCC cases stained with CTS, invasion into connective tissue and keratin pearls were strikingly evident. castanospermine 50-53 serpin family B member 3 Homo sapiens 27-30 28780363-1 2017 BACKGROUND: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Voriconazole 12-24 serpin family B member 3 Homo sapiens 115-118 28780363-6 2017 RESULTS: In multivariate analysis, voriconazole use increased the risk for NMSC (hazard ratio, 1.82; 95% confidence interval, 1.13-2.91) among those who had undergone allogeneic HCT, particularly for SCC (hazard ratio, 2.25; 95% confidence interval, 1.30-3.89). Voriconazole 35-47 serpin family B member 3 Homo sapiens 200-203 28780363-9 2017 CONCLUSION: Voriconazole use represents an independent factor that may contribute to increased risk specifically for SCC in the allogeneic HCT population. Voriconazole 12-24 serpin family B member 3 Homo sapiens 117-120 29142391-5 2017 Morphological changes of ACS treated SCC-25 cells was evaluated by acridine orange/ethidium bromide (AO/EB) dual staining. Acridine Orange 67-82 serpin family B member 3 Homo sapiens 37-40 29142391-5 2017 Morphological changes of ACS treated SCC-25 cells was evaluated by acridine orange/ethidium bromide (AO/EB) dual staining. Ethidium 83-99 serpin family B member 3 Homo sapiens 37-40 29142391-7 2017 Results: A. catechu ethanol seed extract treatment caused cytotoxicity in SCC-25 cells with an IC50 value of 100 mug/mL. Ethanol 20-27 serpin family B member 3 Homo sapiens 74-77 29142391-11 2017 Conclusion: The ethanol seed extracts of A. catechu was found to be cytotoxic at lower concentrations and induced apoptosis in human oral squamous carcinoma SCC-25 cells. Ethanol 16-23 serpin family B member 3 Homo sapiens 157-160 28530728-1 2017 Coulomb explosion of diiodomethane CH2I2 molecules irradiated by ultrashort and intense X-ray pulses from SACLA, the Japanese X-ray free electron laser facility, was investigated by multi-ion coincidence measurements and self-consistent charge density-functional-based tight-binding (SCC-DFTB) simulations. methylene iodide 21-34 serpin family B member 3 Homo sapiens 284-287 29019330-3 2017 The frequency of such spread is greater than 20% for most H&N squamous cell carcinomas (SCC). Adenosine Monophosphate 60-63 serpin family B member 3 Homo sapiens 92-95 28894577-3 2017 The aim of the present study was to assess the feasibility and efficacy of irinotecan and cisplatin in the management of patients with vaginal squamous cell cancer (SCC). Irinotecan 75-85 serpin family B member 3 Homo sapiens 165-168 28894577-3 2017 The aim of the present study was to assess the feasibility and efficacy of irinotecan and cisplatin in the management of patients with vaginal squamous cell cancer (SCC). Cisplatin 90-99 serpin family B member 3 Homo sapiens 165-168 28894577-11 2017 Thus, neoadjuvant chemotherapy with irinotecan combined with cisplatin is a feasible treatment for patients with early-stage vaginal SCC. Irinotecan 36-46 serpin family B member 3 Homo sapiens 133-136 28894577-11 2017 Thus, neoadjuvant chemotherapy with irinotecan combined with cisplatin is a feasible treatment for patients with early-stage vaginal SCC. Cisplatin 61-70 serpin family B member 3 Homo sapiens 133-136 28927142-3 2017 An MTT assay and western blot analysis were performed to determine cell viability and protein expression, respectively, in the SK-MES-1 and SW900 SCC cell lines following treatment with ATO. Arsenic Trioxide 186-189 serpin family B member 3 Homo sapiens 146-149 28927142-5 2017 The results demonstrated that SK-MES-1 and SW900 SCC cells were sensitive to clinically relevant concentrations of ATO. Arsenic Trioxide 115-118 serpin family B member 3 Homo sapiens 49-52 28927142-9 2017 In conclusion, ATO suppresses the growth of SCC in vitro and in vivo. Arsenic Trioxide 15-18 serpin family B member 3 Homo sapiens 44-47 28811537-8 2017 In 4-NQO-induced tongue cancer murine model, mTOR inhibitors significantly decreased the incidence of tongue SCC. 4-Nitroquinoline-1-oxide 3-8 serpin family B member 3 Homo sapiens 109-112 28530728-4 2017 The release of kinetic energy into atomic ion fragments is also studied by comparing SCC-DFTB simulations with the experiment. dftb 89-93 serpin family B member 3 Homo sapiens 85-88 28530728-8 2017 We demonstrate, with good agreement between the experiment and the SCC-DFTB simulation, how the more heavily charged iodine fragments and their interplay define the characteristic features of the Coulomb explosion of CH2I2. dftb 71-75 serpin family B member 3 Homo sapiens 67-70 28530728-8 2017 We demonstrate, with good agreement between the experiment and the SCC-DFTB simulation, how the more heavily charged iodine fragments and their interplay define the characteristic features of the Coulomb explosion of CH2I2. Iodine 117-123 serpin family B member 3 Homo sapiens 67-70 28551620-3 2017 We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on beta-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. nilotinib 57-66 serpin family B member 3 Homo sapiens 148-151 28464542-1 2017 BACKGROUND: The purpose of this study was to determine the impact of CT-determined pretreatment primary tumor volume on survival and disease control in T4a laryngeal squamous cell carcinoma (SCC). Carbon Tetrachloride 69-71 serpin family B member 3 Homo sapiens 191-194 28878647-9 2017 To the best of our knowledge, this is the first report of transformation to SCC after treatment with afatinib. Afatinib 101-109 serpin family B member 3 Homo sapiens 76-79 28834900-13 2017 ss-catenin immunostain showed reduced membranous expression in the SCC component, as compared to HCC. ss-catenin 0-10 serpin family B member 3 Homo sapiens 67-70 28675081-2 2017 METHODS: This was a single-arm retrospective study of chemotherapy with gemcitabine plus cisplatin (GP) administered via BAI to patients with unresectable lung SCC. gemcitabine 72-83 serpin family B member 3 Homo sapiens 160-163 28675081-2 2017 METHODS: This was a single-arm retrospective study of chemotherapy with gemcitabine plus cisplatin (GP) administered via BAI to patients with unresectable lung SCC. Cisplatin 89-98 serpin family B member 3 Homo sapiens 160-163 28611447-5 2017 Chronic liver injury by CCl4 administration or by feeding a methionine/choline deficient diet to transgenic mice over-expressing human SerpinB3 in hepatocytes confirmed that SerpinB3 over-expression significantly increased the mRNA levels of pro-fibrogenic genes, collagen deposition and alphaSMA-positive HSC/MFs as compared to wild-type mice, without affecting parenchymal damage. Carbon Tetrachloride 24-28 serpin family B member 3 Homo sapiens 174-182 28611447-5 2017 Chronic liver injury by CCl4 administration or by feeding a methionine/choline deficient diet to transgenic mice over-expressing human SerpinB3 in hepatocytes confirmed that SerpinB3 over-expression significantly increased the mRNA levels of pro-fibrogenic genes, collagen deposition and alphaSMA-positive HSC/MFs as compared to wild-type mice, without affecting parenchymal damage. Methionine 60-70 serpin family B member 3 Homo sapiens 174-182 28611447-5 2017 Chronic liver injury by CCl4 administration or by feeding a methionine/choline deficient diet to transgenic mice over-expressing human SerpinB3 in hepatocytes confirmed that SerpinB3 over-expression significantly increased the mRNA levels of pro-fibrogenic genes, collagen deposition and alphaSMA-positive HSC/MFs as compared to wild-type mice, without affecting parenchymal damage. Choline 71-78 serpin family B member 3 Homo sapiens 174-182 28551620-3 2017 We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on beta-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. Erlotinib Hydrochloride 79-88 serpin family B member 3 Homo sapiens 148-151 28551620-3 2017 We analyzed the effect of the tyrosine kinase inhibitors nilotinib, dasatinib, erlotinib and gefitinib on beta-catenin and E-cadherin expression in SCC with respect to human papillomavirus (HPV) status. Gefitinib 93-102 serpin family B member 3 Homo sapiens 148-151 28152570-7 2017 Total niacin intake was inversely associated with SCC risk; the pooled HR for top vs. bottom quintiles was 0.84 (95% CI = 0.74-0.95; ptrend = 0.08). Niacin 6-12 serpin family B member 3 Homo sapiens 50-53 28284717-7 2017 Small molecular compounds, including lysyl oxidase inhibitors and reactive oxygen species-inducing reagents such as phenformin, significantly accelerate the transition from lung ADC to SCC and thus confer lung tumors with drug resistance. Reactive Oxygen Species 66-89 serpin family B member 3 Homo sapiens 185-188 28284717-7 2017 Small molecular compounds, including lysyl oxidase inhibitors and reactive oxygen species-inducing reagents such as phenformin, significantly accelerate the transition from lung ADC to SCC and thus confer lung tumors with drug resistance. Phenformin 116-126 serpin family B member 3 Homo sapiens 185-188 28152570-11 2017 Our study supports a potential beneficial role of niacin intake in relation to SCC but not of BCC or melanoma. Niacin 50-56 serpin family B member 3 Homo sapiens 79-82 28496082-6 2017 TBB was performed again and the tumor was diagnosed as SCC. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate 0-3 serpin family B member 3 Homo sapiens 55-58 28314866-11 2017 CONCLUSIONS Combined therapy of attrition with ALA-PDT significantly elevated the effective treatment rate and can decrease the recurrence rate with reliable safety in treating SCC, thus ALA-PDT can be used as an optimal plan for SCC treatment. Alanine 47-50 serpin family B member 3 Homo sapiens 177-180 28515926-1 2017 Treatment with 5-fluorouracil (5-FU) and cisplatin (PF regimen) remains the most frequently used chemotherapy for esophageal squamous cell carcinoma (SCC). Fluorouracil 15-29 serpin family B member 3 Homo sapiens 150-153 28515926-1 2017 Treatment with 5-fluorouracil (5-FU) and cisplatin (PF regimen) remains the most frequently used chemotherapy for esophageal squamous cell carcinoma (SCC). Fluorouracil 31-35 serpin family B member 3 Homo sapiens 150-153 28515926-1 2017 Treatment with 5-fluorouracil (5-FU) and cisplatin (PF regimen) remains the most frequently used chemotherapy for esophageal squamous cell carcinoma (SCC). Cisplatin 41-50 serpin family B member 3 Homo sapiens 150-153 28515926-1 2017 Treatment with 5-fluorouracil (5-FU) and cisplatin (PF regimen) remains the most frequently used chemotherapy for esophageal squamous cell carcinoma (SCC). pyrazofurin 52-54 serpin family B member 3 Homo sapiens 150-153 28351587-7 2017 The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p=0.0297; and 71% vs. 69%, p=0.0231, respectively). dss 11-14 serpin family B member 3 Homo sapiens 38-41 28423494-3 2017 In this study, we have identified TnTs in tumor cells derived from squamous cell carcinomas (SCC) cultured under bi-dimensional and tri-dimensional conditions and also in human SCC tissues. tnts 34-38 serpin family B member 3 Homo sapiens 93-96 28423494-3 2017 In this study, we have identified TnTs in tumor cells derived from squamous cell carcinomas (SCC) cultured under bi-dimensional and tri-dimensional conditions and also in human SCC tissues. tnts 34-38 serpin family B member 3 Homo sapiens 177-180 28658769-5 2017 RESULTS: Podoplanin expression was significantly higher in laryngeal SCC (90%) than laryngeal dysplastic lesions (55%) (p-value=0.002). podoplanin 9-19 serpin family B member 3 Homo sapiens 69-72 28454431-7 2017 The results of the present study suggest that a diffuse Ki-67 staining pattern may be used to diagnose SCC, while a central CK17 staining pattern indicates KA. KS I 56-58 serpin family B member 3 Homo sapiens 103-106 28099404-9 2017 Fair skin type, multiple tumors before retransplantation, treatment with azathioprine, T cell-depleting antibodies, and delayed revision of immunosuppression were associated with an increased risk of aggressive cutaneous SCC after retransplantation. Azathioprine 73-85 serpin family B member 3 Homo sapiens 221-224 28314866-11 2017 CONCLUSIONS Combined therapy of attrition with ALA-PDT significantly elevated the effective treatment rate and can decrease the recurrence rate with reliable safety in treating SCC, thus ALA-PDT can be used as an optimal plan for SCC treatment. Alanine 47-50 serpin family B member 3 Homo sapiens 230-233 28314866-11 2017 CONCLUSIONS Combined therapy of attrition with ALA-PDT significantly elevated the effective treatment rate and can decrease the recurrence rate with reliable safety in treating SCC, thus ALA-PDT can be used as an optimal plan for SCC treatment. Alanine 187-190 serpin family B member 3 Homo sapiens 177-180 28314866-11 2017 CONCLUSIONS Combined therapy of attrition with ALA-PDT significantly elevated the effective treatment rate and can decrease the recurrence rate with reliable safety in treating SCC, thus ALA-PDT can be used as an optimal plan for SCC treatment. Alanine 187-190 serpin family B member 3 Homo sapiens 230-233 31093350-3 2017 In this report, we present the clinical presentation, diagnosis, and management of a patient with HPV-related SCC of the oropharynx that responded favorably to chemotherapy with cisplatin plus etoposide and concomitant radiation therapy, a regimen typically used in SCLC. Cisplatin 178-187 serpin family B member 3 Homo sapiens 110-113 28025447-1 2017 INTRODUCTION: The efficacy of platinum-based adjuvant chemotherapy (PBAC) for pathological stage II and stage III squamous cell carcinoma (SCC) of the lung was analyzed retrospectively. Platinum 30-38 serpin family B member 3 Homo sapiens 139-142 27902867-8 2017 OS for glottic and nonglottic laryngeal SCC recurrence was 45% and 0%, respectively. Osmium 0-2 serpin family B member 3 Homo sapiens 40-43 31093350-3 2017 In this report, we present the clinical presentation, diagnosis, and management of a patient with HPV-related SCC of the oropharynx that responded favorably to chemotherapy with cisplatin plus etoposide and concomitant radiation therapy, a regimen typically used in SCLC. Etoposide 193-202 serpin family B member 3 Homo sapiens 110-113 28009877-2 2017 In this work, density functional theory (DFT) and self-consistent-charge density-functional tight-binding (SCC-DFTB) methods have been used to investigate the properties of magnesium hydroxide and calcium hydroxide nanostructures. dftb 111-115 serpin family B member 3 Homo sapiens 107-110 28152974-9 2017 CONCLUSIONS: EUS and ME perform better than non-ME for diagnosing invasion depth in SCC. methionylglutamic acid 21-23 serpin family B member 3 Homo sapiens 84-87 28009877-2 2017 In this work, density functional theory (DFT) and self-consistent-charge density-functional tight-binding (SCC-DFTB) methods have been used to investigate the properties of magnesium hydroxide and calcium hydroxide nanostructures. Magnesium Hydroxide 173-192 serpin family B member 3 Homo sapiens 107-110 28009877-2 2017 In this work, density functional theory (DFT) and self-consistent-charge density-functional tight-binding (SCC-DFTB) methods have been used to investigate the properties of magnesium hydroxide and calcium hydroxide nanostructures. Calcium Hydroxide 197-214 serpin family B member 3 Homo sapiens 107-110 28009877-4 2017 The accuracy of the DFT methods employed and SCC-DFTB parameters developed in this study were validated against available experimental data. dftb 49-53 serpin family B member 3 Homo sapiens 45-48 27998415-8 2016 An additive interaction was seen between serum folate deficiency and high expression of p16 protein in the CINI, CINII/III and SCC group. Folic Acid 47-53 serpin family B member 3 Homo sapiens 127-130 28274400-4 2017 METHODS AND MATERIALS: We identified 21 patients with primary tonsillar SCC that were treated with TORS followed by RT to the ipsilateral neck and primary (N+P) site. tors 99-103 serpin family B member 3 Homo sapiens 72-75 27197583-4 2016 Logistic regression analysis was used to adjust for the effect of confounders such as age, parity, oral contraceptive use, tobacco smoking, and menopausal status, and revealed that the MPO -463G&gt;A single nucleotide polymorphism (SNP) was associated with an increased risk of SCC. Adenosine Monophosphate 195-198 serpin family B member 3 Homo sapiens 282-285 27197583-6 2016 Stratified analyses between the MPO -463G&gt;A polymorphism and SCC risks demonstrated a protective role of the MPO -463G&gt;A SNP in patients with a positive history of parity and negative history of tobacco smoking. Adenosine Monophosphate 42-45 serpin family B member 3 Homo sapiens 68-71 27197583-6 2016 Stratified analyses between the MPO -463G&gt;A polymorphism and SCC risks demonstrated a protective role of the MPO -463G&gt;A SNP in patients with a positive history of parity and negative history of tobacco smoking. Adenosine Monophosphate 126-129 serpin family B member 3 Homo sapiens 68-71 27197583-9 2016 CONCLUSIONS: Our study demonstrated that the MPO -463G&gt;A SNP may protect from SCC in women from Polish Caucasian populations. Adenosine Monophosphate 55-58 serpin family B member 3 Homo sapiens 85-88 27771945-3 2017 Here, we use 2 nm (metal core) gold nanoparticles to target human hepatocellular carcinoma (HepG2) cells stably transfected with the SERPINB3 (SB3) protein. Metals 19-24 serpin family B member 3 Homo sapiens 133-141 27771945-3 2017 Here, we use 2 nm (metal core) gold nanoparticles to target human hepatocellular carcinoma (HepG2) cells stably transfected with the SERPINB3 (SB3) protein. Metals 19-24 serpin family B member 3 Homo sapiens 143-146 27890239-5 2017 This article identifies a potential role for interleukin-22 in driving SCC proliferation, particularly in solid organ transplant recipients taking cyclosporine. Cyclosporine 147-159 serpin family B member 3 Homo sapiens 71-74 27646608-8 2017 SCC subtype had a better CSS and OS compared to AC and ASC subtype. thiocysteine 25-28 serpin family B member 3 Homo sapiens 0-3 27646608-8 2017 SCC subtype had a better CSS and OS compared to AC and ASC subtype. Osmium 33-35 serpin family B member 3 Homo sapiens 0-3 27678492-2 2017 Voriconazole exposure after lung transplant has recently been reported as a risk factor for SCC. Voriconazole 0-12 serpin family B member 3 Homo sapiens 92-95 27678492-3 2017 We sought to study the relationship between fungal prophylaxis with voriconazole and the risk of SCC in sequential cohorts from a single center. Voriconazole 68-80 serpin family B member 3 Homo sapiens 97-100 27678492-9 2017 Voriconazole exposure was greater in the universal prophylaxis cohort, and the cumulative exposure to voriconazole was associated with SCC (HR 1.75, P < 0.01), even after adjustment for other important SCC risk factors. Voriconazole 102-114 serpin family B member 3 Homo sapiens 135-138 27678492-9 2017 Voriconazole exposure was greater in the universal prophylaxis cohort, and the cumulative exposure to voriconazole was associated with SCC (HR 1.75, P < 0.01), even after adjustment for other important SCC risk factors. Voriconazole 102-114 serpin family B member 3 Homo sapiens 205-208 27106232-3 2016 Oncomine datamining (transcript analyses) reveal that TRAIL is upregulated in 167 SCC as compared to 350 AC patients from six data sets. oncomine 0-8 serpin family B member 3 Homo sapiens 82-85 27163483-5 2016 The overall summary estimate showed a significantly increased risk of SCC in relation to azathioprine exposure (1.56, 95% confidence interval [CI] 1.11-2.18). Azathioprine 89-101 serpin family B member 3 Homo sapiens 70-73 27163483-8 2016 The pooled findings of available evidence support the contention that treatment with azathioprine increases the risk of SCC in OTRs. Azathioprine 85-97 serpin family B member 3 Homo sapiens 120-123 27832256-14 2016 Kaplan-Meier survival analysis showed that SCC of the upper and lower lip had similar overall survival (163.6 months vs 163.8 months) and DSS (418.6 months vs 423.6 months). dss 138-141 serpin family B member 3 Homo sapiens 43-46 27832256-15 2016 In contrast, SCC of the oral commissure had significantly lower overall survival (128.5 months) and DSS (286.7 months). dss 100-103 serpin family B member 3 Homo sapiens 13-16 26660140-8 2016 Women treated with tamoxifen had an IRR 1.06 (95 % CI 0.72-1.55) for SCC and an IRR 1.40 (95 % CI 0.95-2.08) for melanoma when compared to non-users. Tamoxifen 19-28 serpin family B member 3 Homo sapiens 69-72 27793952-5 2016 CASE SERIES: Herein, we report a case series of cutaneous squamous cell carcinoma (SCC) occurring secondary to imatinib in two patients treated for GISTs. Imatinib Mesylate 111-119 serpin family B member 3 Homo sapiens 83-86 27793952-8 2016 Few cases of cutaneous SCC secondary to imatinib therapy were reported in patients with chronic myeloid leukemia. Imatinib Mesylate 40-48 serpin family B member 3 Homo sapiens 23-26 27793952-10 2016 CONCLUSION: To our knowledge, the present report is the first to describe imatinib-related SCC in patients undergoing treatment for GISTs. Imatinib Mesylate 74-82 serpin family B member 3 Homo sapiens 91-94 27895918-13 2016 However, in the SCC group, samples showing loss of HLA-A or loss of total classical HLA but positive for HLA-G were linked to poor patient survival (DSS P = 0.001 and P = 0.01; DFS P = 0.003 and P = 0.01, for HLA-A and total classical HLA, respectively). dss 149-152 serpin family B member 3 Homo sapiens 16-19 27157247-10 2016 LN negative, LVI positive (LVI+/LN-) patients with SCC had higher risk of recurrence and cancer-specific mortality compared to LN positive, LVI negative (LVI-/LN+) patients with SCC (hazard ratio = 2.8 vs. 1.9 and hazard ratio = 3.6 vs. 2.2, respectively). lvi 13-16 serpin family B member 3 Homo sapiens 51-54 28133012-1 2016 BACKGROUND: The goal of this retrospective study was to investigate the efficacy and safety of preoperative chemoradiotherapy( NACR)in patients with Stage II or Stage III esophageal squamous cell carcinoma(SCC). nacr 127-131 serpin family B member 3 Homo sapiens 206-209 27696538-7 2016 This suggests that epigenetic alterations in NMBA-induced rat esophageal tumorigenesis recapitulate epigenetic events in human esophageal SCC, and that BRBs could be useful in preventing the aberrant DNA methylation involved in the development of human esophageal SCC. nitrosobenzylmethylamine 45-49 serpin family B member 3 Homo sapiens 138-141 27696538-7 2016 This suggests that epigenetic alterations in NMBA-induced rat esophageal tumorigenesis recapitulate epigenetic events in human esophageal SCC, and that BRBs could be useful in preventing the aberrant DNA methylation involved in the development of human esophageal SCC. nitrosobenzylmethylamine 45-49 serpin family B member 3 Homo sapiens 264-267 27755795-2 2016 There are no reports describing soft tissue metastasis in lung squamous cell carcinoma (SCC), in which gefitinib treatment was effective not only for the primary tumor but also the metastatic lesion. Gefitinib 103-112 serpin family B member 3 Homo sapiens 88-91 27315356-2 2016 The current phase 2 study evaluated the efficacy and tolerability of dovitinib, an FGFR inhibitor, in patients with advanced SCC of the lung. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 69-78 serpin family B member 3 Homo sapiens 125-128 27315356-14 2016 CONCLUSIONS: Treatment with dovitinib demonstrated modest efficacy in patients with advanced SCC with FGFR1 amplification. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 28-37 serpin family B member 3 Homo sapiens 93-96 27315356-15 2016 Further studies to evaluate other biomarkers correlated with the efficacy of dovitinib in patients with SCC are warranted. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 77-86 serpin family B member 3 Homo sapiens 104-107 27662051-5 2016 RESULTS: The evaluation of SCC with H&E and TB stains was highly concordant, with concordant identification of SCC in 96%, 96%, and 94% of tissue layers among the 3 Mohs surgeons ARS, LHG, and AK-A, respectively. Adenosine Monophosphate 38-41 serpin family B member 3 Homo sapiens 27-30 27662051-5 2016 RESULTS: The evaluation of SCC with H&E and TB stains was highly concordant, with concordant identification of SCC in 96%, 96%, and 94% of tissue layers among the 3 Mohs surgeons ARS, LHG, and AK-A, respectively. Tolonium Chloride 48-50 serpin family B member 3 Homo sapiens 27-30 27662051-6 2016 CONCLUSION: Toluidine blue and H&E stains are statistically similar in their ability to detect SCC and guide Mohs surgical decision-making. Tolonium Chloride 12-26 serpin family B member 3 Homo sapiens 99-102 26876359-1 2016 BACKGROUND: Oxidative DNA damage leads to abnormalities in endogenous cellular processes and constitutes a direct link between free radicals, antioxidants and squamous cell carcinoma (SCC). Free Radicals 127-140 serpin family B member 3 Homo sapiens 184-187 27785069-5 2016 Overall, compared with the control group, a significantly increased SCC risk was observed for the MDM2 rs2279744 polymorphism in the Asian population (test of association: odds ratio [OR] 1.12, P=0.027 for G vs T; OR 1.26, P=0.016 for GG vs TT; OR 1.25, P<0.001 for GG vs TT + TG; and OR 1.08, P=0.023 for carrier G vs T). Thioguanine 280-282 serpin family B member 3 Homo sapiens 68-71 27785069-6 2016 In subgroup analysis by SCC type, a similarly increased esophageal SCC risk was detected (OR 1.19, P<0.001 for G vs T; OR 1.46, P<0.001 for GG vs TT; and OR 1.48, P=0.005 for GG vs TT + TG). Thioguanine 192-194 serpin family B member 3 Homo sapiens 67-70 27670699-6 2016 We show that inhibition of ERK1/2 activation using selumetinib efficiently inhibits the growth of lung SCC with TRA2B-DNAH5 fusion expression. AZD 6244 51-62 serpin family B member 3 Homo sapiens 103-106 27567085-2 2016 We hypothesized that repeated treatments with ingenol mebutate (IngMeb) would postpone development of SCC in hairless mice, and that application of a corticosteroid would reduce IngMeb-induced local skin responses (LSRs) without affecting tumor postponement. 3-ingenyl angelate 46-62 serpin family B member 3 Homo sapiens 102-105 27630328-2 2016 The aim of the study was to study whether TB correlates with aggressiveness in cutaneous SCC. Terbium 42-44 serpin family B member 3 Homo sapiens 89-92 27630328-4 2016 TB was expressed as the mean number of tumour buds in five adjacent high-power fields of each SCC. Terbium 0-2 serpin family B member 3 Homo sapiens 94-97 27630328-5 2016 RESULTS: Aggressive SCC had a much higher TB score compared to control SCC (1.63+-1.35 vs. 0.49+-0.9, p<0.001). Terbium 42-44 serpin family B member 3 Homo sapiens 20-23 27630328-7 2016 Further studies including a larger number of tumours will hopefully validate TB as a new pathological predictor of aggressiveness in cutaneous SCC and will allow its correlation with other pathological features of SCC aggressiveness to be defined. Terbium 77-79 serpin family B member 3 Homo sapiens 143-146 27381830-8 2016 For non-melanoma skin cancers, compared with high-mtCN group, low-mtCN group had an increased risk for SCC (OR = 1.26, 95% CI = 0.93-1.71) and BCC (OR = 1.35; 95% CI = 1.00-1.82). mtcn 66-70 serpin family B member 3 Homo sapiens 103-106 27584160-2 2016 OSSN ranges from mild, moderate, severe dysplasia, carcinoma in situ (CIS) to squamous cell carcinoma (SCC). ossn 0-4 serpin family B member 3 Homo sapiens 103-106 27557122-2 2016 However, epidemiologic studies on orally taken vitamin D and risk of skin cancer (basal cell carcinoma [BCC], squamous cell carcinoma [SCC], and melanoma) are few. Vitamin D 47-56 serpin family B member 3 Homo sapiens 135-138 27148422-2 2016 We present a case of ALK gene translocation-SCC in which a remarkable tumor response to crizotinib was achieved after the failure of prior chemoradiotherapy. Crizotinib 88-98 serpin family B member 3 Homo sapiens 44-47 27699266-5 2016 Eighteen of 114 OTRs developed catastrophic SCC, which was strongly associated with CSA treatment. Cyclosporine 84-87 serpin family B member 3 Homo sapiens 44-47 27699266-6 2016 We found that CSA drives T cell polarization toward IL-22-producing T22 cells, and CSA treatment increased IL-22 receptor in SCC cells. Cyclosporine 83-86 serpin family B member 3 Homo sapiens 125-128 27699266-8 2016 CSA potentiated rescue by IL-22 of serum-starved SCC cells; treatment of SCC cells with IL-22 and CSA increased both their migratory and invasive capacity. Cyclosporine 0-3 serpin family B member 3 Homo sapiens 49-52 27699266-10 2016 We found that catastrophic SCC in OTRs is associated with CSA use, which may be acting by favoring T22 polarization. Cyclosporine 58-61 serpin family B member 3 Homo sapiens 27-30 27102062-3 2016 Under local anesthesia with 5% lidocaine, the hyperplastic and ulcerative SCC of the lip were curetted and assisted by topical PDTs after surgery. Lidocaine 31-40 serpin family B member 3 Homo sapiens 74-77 27118047-7 2016 MAIN FINDINGS: CRT with mitomycin C (MMC) and 5-fluorouracil (5-FU) has been proven to have effective results in the treatment of anal SCC. Mitomycin 24-35 serpin family B member 3 Homo sapiens 135-138 27118047-7 2016 MAIN FINDINGS: CRT with mitomycin C (MMC) and 5-fluorouracil (5-FU) has been proven to have effective results in the treatment of anal SCC. Mitomycin 37-40 serpin family B member 3 Homo sapiens 135-138 27118047-7 2016 MAIN FINDINGS: CRT with mitomycin C (MMC) and 5-fluorouracil (5-FU) has been proven to have effective results in the treatment of anal SCC. Fluorouracil 46-60 serpin family B member 3 Homo sapiens 135-138 27118047-7 2016 MAIN FINDINGS: CRT with mitomycin C (MMC) and 5-fluorouracil (5-FU) has been proven to have effective results in the treatment of anal SCC. Fluorouracil 62-66 serpin family B member 3 Homo sapiens 135-138 27118047-10 2016 CONCLUSIONS: Primary CRT with MMC and 5-FU is the current standard treatment for anal SCC. Mitomycin 30-33 serpin family B member 3 Homo sapiens 86-89 27118047-10 2016 CONCLUSIONS: Primary CRT with MMC and 5-FU is the current standard treatment for anal SCC. Fluorouracil 38-42 serpin family B member 3 Homo sapiens 86-89 27453110-9 2016 Moreover, the results by GMDR model revealed there were interaction among serum folate deficiency, RBC folate deficiency, MeCP2 protein high expression and MeCP2 mRNA high expression in SCC and CIN2 + patients. gmdr 25-29 serpin family B member 3 Homo sapiens 186-189 27453110-9 2016 Moreover, the results by GMDR model revealed there were interaction among serum folate deficiency, RBC folate deficiency, MeCP2 protein high expression and MeCP2 mRNA high expression in SCC and CIN2 + patients. Folic Acid 80-86 serpin family B member 3 Homo sapiens 186-189 27055395-7 2016 In patients with NSCLC, the most cost-effective strategies were SBRT for AC ($156,725/0.80), paclitaxel/carboplatin for SCC ($123,799/0.48), and erlotinib for EGFRm AC ($147,091/1.90). Carboplatin 104-115 serpin family B member 3 Homo sapiens 120-123 27178693-5 2016 Notably, patients on sirolimus have lower incidence of SCC compared to patients on calcineurin inhibitors. Sirolimus 21-30 serpin family B member 3 Homo sapiens 55-58 27178693-6 2016 Revision of immunosuppressive regimen to include sirolimus may be a viable preventative measure against SCC in SOTRs who are high at risk for developing SCCs. Sirolimus 49-58 serpin family B member 3 Homo sapiens 104-107 27178693-8 2016 Treatments of SCC include electrodesiccation and curettage, surgical resection, cryosurgery, radiation, and systemic chemotherapy such as 5-fluorouracil and cetuximab. Fluorouracil 138-152 serpin family B member 3 Homo sapiens 14-17 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. Heme 27-31 serpin family B member 3 Homo sapiens 62-65 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 45-48 serpin family B member 3 Homo sapiens 62-65 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. Heme 78-82 serpin family B member 3 Homo sapiens 62-65 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. Heme 78-82 serpin family B member 3 Homo sapiens 62-65 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. Heme 78-82 serpin family B member 3 Homo sapiens 62-65 26876536-5 2016 The results indicated that heme oxidation by ODQ in truncated sCC induced the heme-associated alphaF helix moving away from the heme, the Per/Arnt/Sim domain (PAS) domain moving closer to the heme, but led the helical domain going further from the heme. Heme 78-82 serpin family B member 3 Homo sapiens 62-65 27070449-4 2016 Furthermore, high expression of MAGE-A, but not NY-ESO-1, was seen in whole slide evaluations of an independent cohort of metastatic SCC (45.5%/3.6%) and metastatic CA (13.5%/0%) of various primaries with significantly higher expression of MAGE-A in metastatic SCC compared with other metastatic CA. mage-a 32-38 serpin family B member 3 Homo sapiens 133-136 27070449-4 2016 Furthermore, high expression of MAGE-A, but not NY-ESO-1, was seen in whole slide evaluations of an independent cohort of metastatic SCC (45.5%/3.6%) and metastatic CA (13.5%/0%) of various primaries with significantly higher expression of MAGE-A in metastatic SCC compared with other metastatic CA. mage-a 32-38 serpin family B member 3 Homo sapiens 261-264 26819410-6 2016 Together, our results demonstrate that DeltaNp63 directly activates the FA pathway in SCC and limits the efficacy of cisplatin treatment. deltanp63 39-48 serpin family B member 3 Homo sapiens 86-89 26945427-9 2016 Multivariate analyses showed that MTV and TLG were the independent prognostic factors for PFS and OS in SCC; in contrast, SUVmax was the independent prognostic factor for PFS and OS in NSCC. mtv 34-37 serpin family B member 3 Homo sapiens 104-107 26461454-2 2016 We reviewed our experience with weekly cisplatin in low-risk, locoregionally advanced HPV(+) oropharyngeal SCC since late 2009. Cisplatin 39-48 serpin family B member 3 Homo sapiens 107-110 26461454-10 2016 CONCLUSION: Concurrent weekly cisplatin is relatively well-tolerated and associated with excellent disease control in low-risk, locoregionally advanced HPV(+) oropharyngeal SCC. Cisplatin 30-39 serpin family B member 3 Homo sapiens 173-176 26613802-7 2016 Multivariate analysis showed that current smokers, T3 to T4 classification, well-differentiated SCC, and nonsurgical treatment were associated with reduced OS. Osmium 156-158 serpin family B member 3 Homo sapiens 96-99 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Phosphatidylcholines 46-65 serpin family B member 3 Homo sapiens 165-168 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Phosphatidylcholines 67-69 serpin family B member 3 Homo sapiens 165-168 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Lysophosphatidylcholines 75-98 serpin family B member 3 Homo sapiens 165-168 26566624-3 2016 In this study, we identified two metabolites, phosphatidylcholine (PC) and lysophosphatidylcholine (LPC), which are significantly down- and upregulated in plasma of SCC as compared to uterine fibroid (UF) patients via ultra-performance liquid chromatographic-mass spectrometry (UPLC-MS). Lysophosphatidylcholines 100-103 serpin family B member 3 Homo sapiens 165-168 25601543-1 2016 OBJECTIVE: To perform a phase II study evaluating a combination of gemcitabine and cisplatin in a population of patients with squamous cell carcinoma (SCC) of the penis and unresected locoregional lymph nodes and/or distant metastases, who had a poor prognosis with no standard of chemotherapy. gemcitabine 67-78 serpin family B member 3 Homo sapiens 151-154 25601543-1 2016 OBJECTIVE: To perform a phase II study evaluating a combination of gemcitabine and cisplatin in a population of patients with squamous cell carcinoma (SCC) of the penis and unresected locoregional lymph nodes and/or distant metastases, who had a poor prognosis with no standard of chemotherapy. Cisplatin 83-92 serpin family B member 3 Homo sapiens 151-154 25601543-11 2016 CONCLUSION: Every 2 weeks" administration of the combination of gemcitabine and cisplatin showed non-significant responses in patients with unresected locoregional or metastatic penile SCC. gemcitabine 64-75 serpin family B member 3 Homo sapiens 185-188 25601543-11 2016 CONCLUSION: Every 2 weeks" administration of the combination of gemcitabine and cisplatin showed non-significant responses in patients with unresected locoregional or metastatic penile SCC. Cisplatin 80-89 serpin family B member 3 Homo sapiens 185-188 26077895-5 2016 The specificity and sensitivity of the combination of 8-OHdG, MDA, vitamin C, and vitamin E are high for the diagnosis of oral pre-cancer and SCC compared to an individual biomarker approach using either 8-OHdG, MDA, or vitamin C and vitamin E independently. Vitamin E 82-91 serpin family B member 3 Homo sapiens 142-145 27198186-7 2016 Bevacizumab (Bev, anti-VEGF monoclonal antibody) is considered as one of key agent with paclitaxel and carboplatin in SCC, but not for ADC. Carboplatin 103-114 serpin family B member 3 Homo sapiens 118-121 27426245-2 2016 Docetaxel and the EGFR tyrosine kinase inhibitor (TKI), erlotinib, are the only two drugs approved for second-line treatment of advanced SCC. Docetaxel 0-9 serpin family B member 3 Homo sapiens 137-140 27426245-2 2016 Docetaxel and the EGFR tyrosine kinase inhibitor (TKI), erlotinib, are the only two drugs approved for second-line treatment of advanced SCC. Erlotinib Hydrochloride 56-65 serpin family B member 3 Homo sapiens 137-140 26563366-5 2016 Using in vitro (SiHa-SCC and HeLa-AC) and BALB-c/SCID models, we demonstrated that lactate metabolism is linked to histological types, with SCC predominantly consuming and AC producing lactate. Lactic Acid 83-90 serpin family B member 3 Homo sapiens 21-24 26563366-5 2016 Using in vitro (SiHa-SCC and HeLa-AC) and BALB-c/SCID models, we demonstrated that lactate metabolism is linked to histological types, with SCC predominantly consuming and AC producing lactate. Lactic Acid 83-90 serpin family B member 3 Homo sapiens 140-143 26563366-7 2016 In vivo models showed that SCC (SiHa) expresses MCT1 and is dependent on lactate to grow, whereas AC (HeLa) expresses MCT1 and MCT4, with higher growth capacities. Lactic Acid 73-80 serpin family B member 3 Homo sapiens 27-30 26945427-9 2016 Multivariate analyses showed that MTV and TLG were the independent prognostic factors for PFS and OS in SCC; in contrast, SUVmax was the independent prognostic factor for PFS and OS in NSCC. (5r)-3-Acetyl-4-Hydroxy-5-Methyl-5-[(1z)-2-Methylbuta-1,3-Dien-1-Yl]thiophen-2(5h)-One 42-45 serpin family B member 3 Homo sapiens 104-107 26797371-1 2016 OBJECTIVE: The purpose of this study was to investigate the usefulness of histogram analysis of dynamic contrast-enhanced MRI (DCE-MRI) parameters for the differentiation of squamous cell carcinoma (SCC) and malignant lymphoma of the oropharynx. ethylene dichloride 127-130 serpin family B member 3 Homo sapiens 199-202 26691173-2 2016 BACKGROUND: Combined chemoradiation with infusional 5-FU and mitomycin is the standard treatment for localized squamous cell carcinoma (SCC) of the anal canal. Fluorouracil 52-56 serpin family B member 3 Homo sapiens 136-139 26691173-2 2016 BACKGROUND: Combined chemoradiation with infusional 5-FU and mitomycin is the standard treatment for localized squamous cell carcinoma (SCC) of the anal canal. Mitomycin 61-70 serpin family B member 3 Homo sapiens 136-139 26691173-4 2016 However, the efficacy of the substitution of 5-FU for capecitabine in anal SCC needs confirmation. Fluorouracil 45-49 serpin family B member 3 Homo sapiens 75-78 26691173-4 2016 However, the efficacy of the substitution of 5-FU for capecitabine in anal SCC needs confirmation. Capecitabine 54-66 serpin family B member 3 Homo sapiens 75-78 26691173-16 2016 CONCLUSIONS: Capecitabine can safely substitute infusional 5-FU in the standard chemoradiation regimen for SCC of the anal cancer, with a locoregional control of 86% in 6 months (CI 95% 0.72-0.94). Capecitabine 13-25 serpin family B member 3 Homo sapiens 107-110 23782408-1 2016 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (18FDG-PET/CT) has been shown to be effective for staging human oral squamous cell carcinoma (SCC) but its application for cats with oral SCC is unknown. Fluorodeoxyglucose F18 0-22 serpin family B member 3 Homo sapiens 180-183 23782408-1 2016 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (18FDG-PET/CT) has been shown to be effective for staging human oral squamous cell carcinoma (SCC) but its application for cats with oral SCC is unknown. Fluorodeoxyglucose F18 0-22 serpin family B member 3 Homo sapiens 224-227 26797371-2 2016 MATERIALS AND METHODS: Pretreatment DCE-MRI was performed in 21 patients with pathologically confirmed oropharyngeal SCC and six patients with malignant lymphoma. ethylene dichloride 36-39 serpin family B member 3 Homo sapiens 117-120 26797371-8 2016 CONCLUSION: Our preliminary evidence using histogram analysis of DCE-MRI parameters based on the whole tumor volume suggests that it might be useful for differentiating SCC from malignant lymphoma of the oropharynx. ethylene dichloride 65-68 serpin family B member 3 Homo sapiens 169-172 26958503-3 2016 The LUX-Lung 8 study has shown superior overall survival (OS), progression-free survival (PFS), as well as disease control rates for treatment with afatinib compared to erlotinib in this head-to-head trial in patients with previously treated advanced SCC of the lung, with manageable side effect profile. Afatinib 148-156 serpin family B member 3 Homo sapiens 251-254 26586792-7 2016 Our earlier studies to elucidate mechanisms of PKCepsilon-mediated development of SCC, using either DMBA-TPA or UVR, indicated elevated release of cytokine TNFalpha. dmba-tpa 100-108 serpin family B member 3 Homo sapiens 82-85 26894011-3 2015 The authors describe, herein, a primary SCC arising from the capsule of a long-standing silicone breast implant. Silicones 88-96 serpin family B member 3 Homo sapiens 40-43 26372838-1 2016 Voriconazole is a triazole antifungal used to prevent and treat invasive fungal infections after lung transplantation, but it has been associated with an increased risk of developing cutaneous squamous cell carcinoma (SCC). Voriconazole 0-12 serpin family B member 3 Homo sapiens 218-221 26372838-4 2016 Voriconazole exposure was associated with a 73% increased risk of developing SCC (hazard ratio [HR] 1.73; 95% confidence interval [CI]: 1.04-2.88; p = 0.03), with each additional 30-day exposure at the standard dose increasing the risk by 3.0% (HR 1.03; 95% CI: 1.02-1.04; p < 0.001). Voriconazole 0-12 serpin family B member 3 Homo sapiens 77-80 26586792-9 2016 We now present that deletion of TNFalpha in TG mice inhibited the development of SCC either by repeated UVR exposures or by the DMBA-TPA protocol. dmba-tpa 128-136 serpin family B member 3 Homo sapiens 81-84 26586792-12 2016 The results presented here provide the first genetic evidence that TNFalpha is linked to PKCepsilon-mediated sensitivity to DMBA-TPA or UVR-induced development of cutaneous SCC. dmba-tpa 124-132 serpin family B member 3 Homo sapiens 173-176 26884827-6 2015 Furthermore, deguelin-treated tumors showed decreased the tumor metastasis related genes such as CD44, MMP2 and MMP9 at protein and mRNA levels and the content of CEA, SCC, NSE, CYFAR21-1. deguelin 13-21 serpin family B member 3 Homo sapiens 168-171 26035047-5 2016 RESULTS: The authors report a significantly higher density of TAMs in both SCCis and SCC. tams 62-66 serpin family B member 3 Homo sapiens 75-78 26637886-2 2015 We conducted a multicenter phase II study of nedaplatin (NP) and irinotecan (CPT) for SCC of the lung. Irinotecan 65-75 serpin family B member 3 Homo sapiens 86-89 26637886-2 2015 We conducted a multicenter phase II study of nedaplatin (NP) and irinotecan (CPT) for SCC of the lung. cpt 77-80 serpin family B member 3 Homo sapiens 86-89 25804347-13 2015 CONCLUSIONS: The regimen of weekly cisplatin CRT may be effective for pyriform sinus SCC; however, there were problems with strong selection bias in the current study due to the large number of T2 patients. Cisplatin 35-44 serpin family B member 3 Homo sapiens 85-88 27855232-0 2016 Novel SCC mutation in a patient of Mexican descent with sex reversal, salt-losing crisis and adrenal failure. Salts 70-74 serpin family B member 3 Homo sapiens 6-9 24996171-5 2016 Five-year disease-specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively. dss 37-40 serpin family B member 3 Homo sapiens 79-82 26547371-8 2015 Mean mtCN was 5.05 +- 8.17 and 3.34 +- 5.14 in ADC and SCC respectively. mtcn 5-9 serpin family B member 3 Homo sapiens 55-58 26547371-9 2015 The mtCN was increased in 35 patients (72.9%) of ADC and 30 (71.4%) of SCC. mtcn 4-8 serpin family B member 3 Homo sapiens 71-74 26403508-8 2015 CONCLUSION: In our cohort, moxifloxacin use and CMV replication during the first year post-transplantation were associated with increased risk for SCC. Moxifloxacin 27-39 serpin family B member 3 Homo sapiens 147-150 26681860-13 2015 RESULTS: MTT assay showed statistically significant (P < 0.001) dose-dependent inhibition of SCC-25 cell lines by Graviola with IC50 value of 12.42 mug/ml. monooxyethylene trimethylolpropane tristearate 9-12 serpin family B member 3 Homo sapiens 96-99 24798404-5 2015 AG825 treatment reduced tumor volume, increased tumor regression, and delayed the development of malignant squamous cell carcinoma (SCC). tyrphostin AG825 0-5 serpin family B member 3 Homo sapiens 132-135 24890445-1 2015 BACKGROUND: The purpose of this study was to determine whether pretreatment 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG PET/CT) volume-based parameters, such as metabolic tumor volume and total lesion glycolysis, add more prognostic information in patients with oropharyngeal squamous cell carcinoma (SCC). Fluorodeoxyglucose F18 76-98 serpin family B member 3 Homo sapiens 318-321 26330924-8 2015 CONCLUSION: In spite of these results, it is worth further investigating the role of pSTAT3 (serine- and tyrosine-pSTAT3) in oral tongue SCC in larger series because preclinical models are increasingly showing that several anticancer strategies would benefit from STAT3 phosphorylation inhibition. Serine 93-99 serpin family B member 3 Homo sapiens 137-140 26644802-12 2015 CONCLUSION: These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. thiocysteine 44-47 serpin family B member 3 Homo sapiens 96-99 26116359-2 2015 Recently, a new compound, ingenol mebutate, was approved for treatment of actinic keratosis, a precursor of SCC. 3-ingenyl angelate 26-42 serpin family B member 3 Homo sapiens 108-111 26138646-0 2015 Sirolimus use and risk of cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients (SOTRs). Sirolimus 0-9 serpin family B member 3 Homo sapiens 61-64 26138646-1 2015 BACKGROUND: Little is known about the use of sirolimus for primary prevention of cutaneous squamous cell carcinoma (SCC) among solid organ transplant recipients (SOTRs). Sirolimus 45-54 serpin family B member 3 Homo sapiens 116-119 26138646-2 2015 OBJECTIVE: We examined the association between sirolimus exposure and incident SCC risk among SOTRs within Kaiser Permanente Northern California. Sirolimus 47-56 serpin family B member 3 Homo sapiens 79-82 26138646-5 2015 We used extended Cox regression to examine the independent association between receipt of sirolimus and risk of SCC. Sirolimus 90-99 serpin family B member 3 Homo sapiens 112-115 25782724-6 2015 To our knowledge, this is the first case of a CXPA that consists of both a high-grade SDC and a keratinizing SCC in the parotid gland. cxpa 46-50 serpin family B member 3 Homo sapiens 109-112 26116359-4 2015 We elucidate direct effects of ingenol mebutate on primary keratinocytes, patient-derived SCC cells, and a SCC cell line. 3-ingenyl angelate 31-47 serpin family B member 3 Homo sapiens 90-93 25680727-8 2015 CONCLUSIONS: Mono + DECT at low keV levels significantly improves CNR and subjective image quality in patients with head and neck SCC, as tumour CNR peaks at 40 keV, and 55 keV images are preferred by observers. mono + dect 13-24 serpin family B member 3 Homo sapiens 130-133 25640031-14 2015 Moreover, long-term diuretic use was associated with SCC risk, driven by potassium-sparing agents alone or in combination with low-ceiling diuretics. Potassium 73-82 serpin family B member 3 Homo sapiens 53-56 26464673-10 2015 Our result suggests that SOX2 might suppress nodal metastasis through down-regulation of podoplanin in esophageal SCC. podoplanin 89-99 serpin family B member 3 Homo sapiens 114-117 26179387-3 2015 METHODS: Two patients with recurrent SCC after primary (chemo)radiotherapy of the BOT were treated with TORS, but unfortunately remained with involved resection margins on the postoperative pathology report. tors 104-108 serpin family B member 3 Homo sapiens 37-40 26132438-8 2015 Chemo-sensitivity of lung SCC cell lines stably transfected with EMX2 shRNAs to cisplatin, carboplatin, and docetaxel was examined in vitro. Cisplatin 80-89 serpin family B member 3 Homo sapiens 26-29 25940810-6 2015 We report the case of a 15-year-old immunocompromised girl with severe recalcitrant condyloma that resolved after a course of systemic 5-fluorouracil, mitomycin C, and radiation therapy for SCC. Fluorouracil 135-149 serpin family B member 3 Homo sapiens 190-193 26132438-8 2015 Chemo-sensitivity of lung SCC cell lines stably transfected with EMX2 shRNAs to cisplatin, carboplatin, and docetaxel was examined in vitro. Carboplatin 91-102 serpin family B member 3 Homo sapiens 26-29 26132438-8 2015 Chemo-sensitivity of lung SCC cell lines stably transfected with EMX2 shRNAs to cisplatin, carboplatin, and docetaxel was examined in vitro. Docetaxel 108-117 serpin family B member 3 Homo sapiens 26-29 25702090-7 2015 In conclusion, fatty acids from erythrocyte phospholipid species might serve as biomarkers in the diagnosis, and probably in other aspects related to clinical disease management, of ADC, SCC, and SCLC. Fatty Acids 15-26 serpin family B member 3 Homo sapiens 187-190 25702090-7 2015 In conclusion, fatty acids from erythrocyte phospholipid species might serve as biomarkers in the diagnosis, and probably in other aspects related to clinical disease management, of ADC, SCC, and SCLC. Phospholipids 44-56 serpin family B member 3 Homo sapiens 187-190 26214637-10 2015 Similarly, CC genotpe of rs2910164 was found to be inversely related to susceptibility of oral SCC (CC+CG vs. GG: OR=0.726, 95% CI=0.607-0.869, p<0.001). cysteinylglycine 103-105 serpin family B member 3 Homo sapiens 95-98 25270617-1 2015 PURPOSE: To describe the use of a pulse-dose topical 5-fluorouracil (5-FU) treatment regimen in a Pug dog with corneal squamous cell carcinoma (SCC). Fluorouracil 53-67 serpin family B member 3 Homo sapiens 144-147 25270617-1 2015 PURPOSE: To describe the use of a pulse-dose topical 5-fluorouracil (5-FU) treatment regimen in a Pug dog with corneal squamous cell carcinoma (SCC). Fluorouracil 69-73 serpin family B member 3 Homo sapiens 144-147 25944691-4 2015 We found that membranous and cytoplasmic IGF-1R expressions were significantly associated with squamous cell carcinoma (SCC) in both of the TMAs. 4,4-dimethylcholesta-8,14-dien-3-ol 140-144 serpin family B member 3 Homo sapiens 120-123 25739673-11 2015 CONCLUSIONS: A gene expression signature of NRF2 pathway activation is associated with benefit from adjuvant cisplatin/vinorelbine in SCC. Cisplatin 109-118 serpin family B member 3 Homo sapiens 134-137 25739673-11 2015 CONCLUSIONS: A gene expression signature of NRF2 pathway activation is associated with benefit from adjuvant cisplatin/vinorelbine in SCC. Vinorelbine 119-130 serpin family B member 3 Homo sapiens 134-137 26902024-1 2015 BACKGROUND/AIMS: The purpose of this study is to assess the efficacy of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in predicting the pathological response of neoadjuvant chemoradiation (CRT) for clinically diagnosed T4 esophageal squamous cell carcinoma (SCC). Fluorodeoxyglucose F18 72-94 serpin family B member 3 Homo sapiens 276-279 26029210-5 2015 Importantly, we found that the hormonally active form of vitamin D 1,25(OH)2D3 not only prevents the UVR-induced small HA activation of abnormal keratinocyte behavior and SCC progression, but also enhances large HA stimulation of normal keratinocyte activities and epidermal function(s). vitamin d 1 57-68 serpin family B member 3 Homo sapiens 171-174 26029210-5 2015 Importantly, we found that the hormonally active form of vitamin D 1,25(OH)2D3 not only prevents the UVR-induced small HA activation of abnormal keratinocyte behavior and SCC progression, but also enhances large HA stimulation of normal keratinocyte activities and epidermal function(s). 25(oh)2d3 69-78 serpin family B member 3 Homo sapiens 171-174 25638604-8 2015 Kaplan-Meier survival analyses showed worse DSS in patients with a clitoral SCC compared to patients without clitoral involvement. dss 44-47 serpin family B member 3 Homo sapiens 76-79 26155488-4 2015 We hereby present a rare case report where patient presented with symptoms of acute pancreatitis & diagnosed with SCC of lung, retrospectively. Adenosine Monophosphate 98-101 serpin family B member 3 Homo sapiens 118-121 25892878-1 2015 AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC). Docetaxel 49-58 serpin family B member 3 Homo sapiens 153-156 25892878-1 2015 AIM: To assess the efficacy and safety of weekly docetaxel plus a fixed-dose rate (FDR) of gemcitabine in metastatic esophageal squamous cell carcinoma (SCC). gemcitabine 91-102 serpin family B member 3 Homo sapiens 153-156 25638604-3 2015 The aim of this study is to assess the disease specific survival (DSS) in patients with clitoral SCC compared to patients with SCC without clitoral involvement. dss 66-69 serpin family B member 3 Homo sapiens 97-100 25573684-6 2015 SCC cell lines are treated with curcumin to regulate PIAS3 expression and cell growth. Curcumin 32-40 serpin family B member 3 Homo sapiens 0-3 25521453-2 2015 To investigate whether the use of aspirin and other NSAIDS reduces the risk of squamous cell carcinoma (SCC), we conducted a systematic review on the basis of published epidemiologic studies and calculated summary estimates for aspirin, nonaspirin NSAIDS, and any NSAIDS use. Aspirin 34-41 serpin family B member 3 Homo sapiens 104-107 25521453-5 2015 There was significant heterogeneity between studies regarding SCC risk estimates for aspirin use and any NSAIDS use. Aspirin 85-92 serpin family B member 3 Homo sapiens 62-65 25975556-11 2015 Both levels of serum folate levels and FHIT protein expression were positively correlated (r = 0.213, P = 0.001), with an additive interaction seen between them in CIN I, CIN II/III, SCC groups. Folic Acid 21-27 serpin family B member 3 Homo sapiens 183-186 25750277-7 2015 CONCLUSION: Re-expression of PKCbeta in head and neck SCC cell lines leads to cells one thousand-times more sensitive to the cytotoxic effects of phorbol or diterpene esters in culture. phorbol 146-153 serpin family B member 3 Homo sapiens 54-57 25750277-7 2015 CONCLUSION: Re-expression of PKCbeta in head and neck SCC cell lines leads to cells one thousand-times more sensitive to the cytotoxic effects of phorbol or diterpene esters in culture. diterpene esters 157-173 serpin family B member 3 Homo sapiens 54-57 25450871-1 2015 BACKGROUND: Platinum-based chemotherapy is the standard first-line therapy for patients with advanced lung squamous cell carcinoma (SCC). Platinum 12-20 serpin family B member 3 Homo sapiens 132-135 25661996-2 2015 In solid organ transplantation, voriconazole use has been associated with the development of cutaneous squamous cell carcinoma (SCC). Voriconazole 32-44 serpin family B member 3 Homo sapiens 128-131 25661996-3 2015 We sought to determine if voriconazole use was associated with SCC in patients undergoing allo-HSCT. Voriconazole 26-38 serpin family B member 3 Homo sapiens 63-66 25661996-5 2015 Multivariable Cox models were created to assess the relationship of SCC with two time-dependent voriconazole exposure variables: (i) history of voriconazole exposure (yes/no), and (ii) cumulative days of voriconazole use. Voriconazole 96-108 serpin family B member 3 Homo sapiens 68-71 25661996-5 2015 Multivariable Cox models were created to assess the relationship of SCC with two time-dependent voriconazole exposure variables: (i) history of voriconazole exposure (yes/no), and (ii) cumulative days of voriconazole use. Voriconazole 144-156 serpin family B member 3 Homo sapiens 68-71 25661996-5 2015 Multivariable Cox models were created to assess the relationship of SCC with two time-dependent voriconazole exposure variables: (i) history of voriconazole exposure (yes/no), and (ii) cumulative days of voriconazole use. Voriconazole 144-156 serpin family B member 3 Homo sapiens 68-71 25661996-6 2015 RESULTS: In our cohort of 381 allo-HSCT patients, SCC developed in 26 of 312 patients exposed to voriconazole (25 post-voriconazole) and in 1 of 69 patients who received alternative antifungal agent(s). Voriconazole 97-109 serpin family B member 3 Homo sapiens 50-53 25661996-6 2015 RESULTS: In our cohort of 381 allo-HSCT patients, SCC developed in 26 of 312 patients exposed to voriconazole (25 post-voriconazole) and in 1 of 69 patients who received alternative antifungal agent(s). Voriconazole 119-131 serpin family B member 3 Homo sapiens 50-53 25661996-8 2015 Cumulative days of voriconazole use was found to be a risk factor for SCC, and this relationship persisted in a multivariable model using previously identified risk factors as covariates (hazard ratio 1.859 for each 180 days of use, P < 0.001). Voriconazole 19-31 serpin family B member 3 Homo sapiens 70-73 25661996-9 2015 CONCLUSION: This is the first study, to our knowledge, to identify cumulative days of voriconazole use as a risk factor for SCC development following allo-HSCT, and may help guide appropriate antifungal use in this patient population. Voriconazole 86-98 serpin family B member 3 Homo sapiens 124-127 25889980-4 2015 In this study, an industrial, xeno-free, pharmaceutical-grade supplement for cell culture (SCC) under development at Grifols was tested for growth of human mesenchymal stem cells (hMSCs), cell characterization, and differentiation capacity. grifols 117-124 serpin family B member 3 Homo sapiens 91-94 25889980-5 2015 METHODS: SCC is a freeze-dried product obtained through cold-ethanol fractionation of industrial human plasma pools from healthy donors. Ethanol 61-68 serpin family B member 3 Homo sapiens 9-12 25573684-9 2015 Curcumin treatment increased endogenous PIAS3 expression and decreased cell growth and viability in Calu-1 cells, a model of SCC. Curcumin 0-8 serpin family B member 3 Homo sapiens 125-128 25351502-1 2015 Transoral CO2 laser cordectomy for squamous cell carcinoma (SCC) of the glottis has resulted in excellent voice and oncologic outcomes as compared with non-surgical therapy. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 10-13 serpin family B member 3 Homo sapiens 60-63 25544768-6 2015 HIF-2alpha-mediated SERPINB3 up-regulation under hypoxic conditions required intracellular generation of ROS. ros 105-108 serpin family B member 3 Homo sapiens 20-28 25351502-2 2015 However, published experience with primary CO2 laser cordectomy specifically for glottic SCC involving the anterior commissure (AC) is limited. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 43-46 serpin family B member 3 Homo sapiens 89-92 25351502-3 2015 A review of single academic institution experience with CO2 laser cordectomy for glottic SCC involving the AC. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 56-59 serpin family B member 3 Homo sapiens 89-92 26054571-8 2015 Next, a statistical comparison of the TBF value by a Mann-Whitney U test between the patients with SCC and IP was performed. formic acid 38-41 serpin family B member 3 Homo sapiens 99-102 25184957-8 2015 Finally, the GLO1 regulation of SCC-13 cells might be relevant to methylglyoxal-induced p53 translocation. Pyruvaldehyde 66-79 serpin family B member 3 Homo sapiens 32-35 25490119-9 2015 A comparison of performance between the density functional theory (DFT) and the computationally less expensive dispersion-corrected self-consistent density functional tight-binding (SCC-DFTB-D) theory revealed that the latter produces consistent energetics for this hydride transfer reaction and additional DFT-computed perturbative corrections could significantly improve these results. dftb 186-190 serpin family B member 3 Homo sapiens 182-185 25966742-5 2015 The transduced SCC cells were treated with different doses of GRh2, and then analyzed cell viability by CCK-8 assay and MTT assay. ginsenoside Rh2 62-66 serpin family B member 3 Homo sapiens 15-18 25966742-5 2015 The transduced SCC cells were treated with different doses of GRh2, and then analyzed cell viability by CCK-8 assay and MTT assay. monooxyethylene trimethylolpropane tristearate 120-123 serpin family B member 3 Homo sapiens 15-18 25633488-4 2015 He had been previously treated by topical 5-fluorouracil for an adjacent microinvasive squamous cell carcinoma (SCC), with complete clinical response. Fluorouracil 42-56 serpin family B member 3 Homo sapiens 112-115 25678188-1 2015 BACKGROUND: Continuous intra-arterial administration of peplomycin (PEP) through a tumor-feeding artery using an intravascular indwelling catheter is one of the best treatments for cutaneous squamous cell carcinoma (SCC) on cosmetic areas. Peplomycin 56-66 serpin family B member 3 Homo sapiens 216-219 25678188-1 2015 BACKGROUND: Continuous intra-arterial administration of peplomycin (PEP) through a tumor-feeding artery using an intravascular indwelling catheter is one of the best treatments for cutaneous squamous cell carcinoma (SCC) on cosmetic areas. Peplomycin 68-71 serpin family B member 3 Homo sapiens 216-219 25590187-13 2015 CONCLUSION: Changes in the morphology of IPCLs on M-NBI correlated with the depth of SCC invasion, and results were reproducible and reliable among observers. m-nbi 50-55 serpin family B member 3 Homo sapiens 85-88 25427912-3 2015 The risks of upper aerodigestive tract SCC/dysplasia, especially of multiple SCC/dysplasia, were increased in a multiplicative fashion by the presence of a combination of slow-metabolizing ADH1B*1/*1 and inactive heterozygous ALDH2*1/*2 because of prolonged exposure to higher concentrations of ethanol/acetaldehyde. Ethanol 295-302 serpin family B member 3 Homo sapiens 39-42 25427912-3 2015 The risks of upper aerodigestive tract SCC/dysplasia, especially of multiple SCC/dysplasia, were increased in a multiplicative fashion by the presence of a combination of slow-metabolizing ADH1B*1/*1 and inactive heterozygous ALDH2*1/*2 because of prolonged exposure to higher concentrations of ethanol/acetaldehyde. Acetaldehyde 303-315 serpin family B member 3 Homo sapiens 39-42 25970228-3 2015 Here, we aimed to investigate the expression of PKM2, its prognostic values and oncogenic functions using 7,12-dimethyl-1,2-bezan-tracene (DMBA)-induced hamster buccal pouch SCC model, primary OSCC specimens as well as in vitro cellular assays. 7,12-dimethyl-1,2-bezan-tracene 106-137 serpin family B member 3 Homo sapiens 174-177 25970228-3 2015 Here, we aimed to investigate the expression of PKM2, its prognostic values and oncogenic functions using 7,12-dimethyl-1,2-bezan-tracene (DMBA)-induced hamster buccal pouch SCC model, primary OSCC specimens as well as in vitro cellular assays. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 139-143 serpin family B member 3 Homo sapiens 174-177 25970228-4 2015 We found that in DMBA-induced OSCC model, negative PKM2 expression was commonly observed in normal epithelial, while more PKM2 abundance was detected in hyperplasia, dysplasia and SCC. 6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene 17-21 serpin family B member 3 Homo sapiens 31-34 25198405-2 2015 Although the development of keratoacanthomas and squamous cell carcinomas (SCC) has been described during vemurafenib therapy, most of the reported cases are treated with surgical excision. Vemurafenib 106-117 serpin family B member 3 Homo sapiens 75-78 25345858-0 2014 Raman spectroscopy differentiates squamous cell carcinoma (SCC) from normal skin following treatment with a high-powered CO2 laser. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 121-124 serpin family B member 3 Homo sapiens 59-62 25934400-1 2015 OBJECTIVES: This study aims to determine whether there is a difference between inverted papilloma (IP) and nasal polyp, and squamous cell carcinoma (SCC) with regard to fluorodeoxyglucose uptake. Fluorodeoxyglucose F18 169-187 serpin family B member 3 Homo sapiens 149-152 25967534-1 2015 Tobacco use and alcohol consumption are the main risk factors associated with head and neck squamous cell carcinoma (SCC) development due to their cytotoxic and mutagenic effects on the exposed epithelia of the upper aerodigestive tract. Alcohols 16-23 serpin family B member 3 Homo sapiens 117-120 25398663-3 2015 Invasive SCC was treated by excision with adjunctive ruthenium plaque radiotherapy. Ruthenium 53-62 serpin family B member 3 Homo sapiens 9-12 25457886-6 2014 RESULTS: SCC multiplicity (-41.3%), tumor incidence (-37.1%), and proliferation rate (-6.9%) were reduced in HCPs receiving BRBs. brbs 124-128 serpin family B member 3 Homo sapiens 9-12 25393577-17 2014 Radiation therapy is associated with improved DSS in SCC but not in ACC. dss 46-49 serpin family B member 3 Homo sapiens 53-56 25403182-4 2014 We further show that miR-125b can confer "oncomiR addiction" in early stage malignant progenitors by delaying their differentiation and favoring an SCC cancer stem cell (CSC)-like transcriptional program. mir-125b 21-29 serpin family B member 3 Homo sapiens 148-151 25245764-5 2014 This model system uses the carcinogen N-nitroso-trischloroethylurea (NTCU), which is applied topically, reliably triggering the development of SCC within 24 to 26 weeks. N-nitroso-tris-chloroethylurea 38-67 serpin family B member 3 Homo sapiens 143-146 25245764-5 2014 This model system uses the carcinogen N-nitroso-trischloroethylurea (NTCU), which is applied topically, reliably triggering the development of SCC within 24 to 26 weeks. N-nitroso-tris-chloroethylurea 69-73 serpin family B member 3 Homo sapiens 143-146 25245764-6 2014 Administration of honokiol significantly reduced the percentage of bronchial that exhibit abnormal lung SCC histology from 24.4% bronchial in control to 11.0% bronchial in honokiol-treated group (P = 0.01) while protecting normal bronchial histology (present in 20.5% of bronchial in control group and 38.5% of bronchial in honokiol-treated group. honokiol 18-26 serpin family B member 3 Homo sapiens 104-107 25245764-9 2014 In vitro studies revealed that honokiol inhibited lung SCC cells proliferation, arrested cells at the G1-S cell-cycle checkpoint, while also leading to increased apoptosis. honokiol 31-39 serpin family B member 3 Homo sapiens 55-58 25245764-10 2014 Our study showed that interfering with mitochondrial respiration is a novel mechanism by which honokiol changed redox status in the mitochondria, triggered apoptosis, and finally leads to the inhibition of lung SCC. honokiol 95-103 serpin family B member 3 Homo sapiens 211-214 25245764-11 2014 This novel mechanism of targeting mitochondrial suggests honokiol as a potential lung SCC chemopreventive agent. honokiol 57-65 serpin family B member 3 Homo sapiens 86-89 25183266-10 2014 Electrochemotherapy with bleomycin is an effective option for skin tumours of the head and neck and is a feasible alternative in highly selected (small, primary, and not previously treated by chemotherapy) SCC of the oral cavity and oropharynx. Bleomycin 25-34 serpin family B member 3 Homo sapiens 206-209