PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34445111-5 2021 The sacs-null fish showed motor impairment, hindbrain atrophy, mitochondrial dysfunction, and reactive oxygen species accumulation. oxygen species 103-117 sacsin molecular chaperone Danio rerio 4-8 34445111-6 2021 As proof of principle for using these mutant fish in high-throughput screening studies, we showed that both acetyl-DL-leucine and tauroursodeoxycholic acid improved locomotor and biochemical phenotypes in sacs-/- larvae treated with these neuroprotective agents, by mediating significant rescue of the molecular functions altered by sacsin loss. ursodoxicoltaurine 130-155 sacsin molecular chaperone Danio rerio 205-209