PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
10681414-2	2000	Bile acid pool sizes, fecal bile acid outputs (synthesis rates), and the activities of cholesterol 7alpha-hydroxylase (classic bile acid synthesis) and cholesterol 27-hydroxylase (alternative bile acid synthesis) were related to ileal bile acid transporter expression (ileal apical sodium-dependent bile acid transporter, ASBT).	Bile Acids and Salts	127-136	cytochrome P450 7A1	Oryctolagus cuniculus	87-117
10681414-9	2000	Classic bile acid synthesis (cholesterol 7alpha-hydroxylase) was inhibited in rabbits because an enlarged bile acid pool developed from enhanced ileal bile acid transport.	Bile Acids and Salts	8-17	cytochrome P450 7A1	Oryctolagus cuniculus	29-59
10681414-9	2000	Classic bile acid synthesis (cholesterol 7alpha-hydroxylase) was inhibited in rabbits because an enlarged bile acid pool developed from enhanced ileal bile acid transport.	Bile Acids and Salts	106-115	cytochrome P450 7A1	Oryctolagus cuniculus	29-59
10681414-9	2000	Classic bile acid synthesis (cholesterol 7alpha-hydroxylase) was inhibited in rabbits because an enlarged bile acid pool developed from enhanced ileal bile acid transport.	Bile Acids and Salts	106-115	cytochrome P450 7A1	Oryctolagus cuniculus	29-59
10681414-11	2000	Therefore, although bile acid synthesis was increased via different pathways in rats and rabbits, enhanced ileal bile acid transport was critical for enlarging the bile acid pool size that exerted feedback regulation on cholesterol 7alpha-hydroxylase in rabbits.	Bile Acids and Salts	113-122	cytochrome P450 7A1	Oryctolagus cuniculus	220-250
10681414-11	2000	Therefore, although bile acid synthesis was increased via different pathways in rats and rabbits, enhanced ileal bile acid transport was critical for enlarging the bile acid pool size that exerted feedback regulation on cholesterol 7alpha-hydroxylase in rabbits.	Bile Acids and Salts	113-122	cytochrome P450 7A1	Oryctolagus cuniculus	220-250
9394736-4	1997	The activities of hepatic cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase that control bile acid synthesis in classic and alternative pathways were related to the size and composition of bile acid pool.	Bile Acids and Salts	197-206	cytochrome P450 7A1	Oryctolagus cuniculus	26-57
10681414-2	2000	Bile acid pool sizes, fecal bile acid outputs (synthesis rates), and the activities of cholesterol 7alpha-hydroxylase (classic bile acid synthesis) and cholesterol 27-hydroxylase (alternative bile acid synthesis) were related to ileal bile acid transporter expression (ileal apical sodium-dependent bile acid transporter, ASBT).	Bile Acids and Salts	127-136	cytochrome P450 7A1	Oryctolagus cuniculus	87-117
10681414-2	2000	Bile acid pool sizes, fecal bile acid outputs (synthesis rates), and the activities of cholesterol 7alpha-hydroxylase (classic bile acid synthesis) and cholesterol 27-hydroxylase (alternative bile acid synthesis) were related to ileal bile acid transporter expression (ileal apical sodium-dependent bile acid transporter, ASBT).	Bile Acids and Salts	127-136	cytochrome P450 7A1	Oryctolagus cuniculus	87-117
9653895-4	1998	Only bezafibrate induced a significant 57% reduction in the activity of hepatic microsomal cholesterol 7alpha-hydroxylase.	Bezafibrate	5-16	cytochrome P450 7A1	Oryctolagus cuniculus	91-121
9884338-2	1999	Feeding cholesterol for one day increased hepatic cholesterol 75% and cholesterol 7alpha-hydroxylase activity 1.6 times without significant change of bile acid pool size or sterol 27-hydroxylase activity.	Cholesterol	8-19	cytochrome P450 7A1	Oryctolagus cuniculus	70-100
9884338-5	1999	Bile drainage depleted the bile acid pool and stimulated downregulated cholesterol 7alpha-hydroxylase activity but did not affect sterol 27-hydroxylase activity.	bile drainage	0-13	cytochrome P450 7A1	Oryctolagus cuniculus	71-101
9884338-6	1999	Thus, increasing hepatic cholesterol does not directly inhibit cholesterol 7alpha-hydroxylase and initially favors enzyme induction, whereas increased bile acid pool is the most powerful inhibitor of cholesterol 7alpha-hydroxylase.	Bile Acids and Salts	151-160	cytochrome P450 7A1	Oryctolagus cuniculus	200-230
9717721-9	1998	These results demonstrated that dietary cholesterol increased hepatic sterol 27-hydroxylase activity and alternative bile acid synthesis to expand the bile acid pool and inhibited cholesterol 7alpha-hydroxylase in NZW and in Watanabe heterozygous rabbits but not in homozygotes with absent hepatic LDL receptor function.	Cholesterol	40-51	cytochrome P450 7A1	Oryctolagus cuniculus	180-210
9717721-10	1998	Thus, in rabbits, sterol 27-hydroxylase is up-regulated by the increased hepatic cholesterol that enters the liver via LDL receptors whereas cholesterol 7alpha-hydroxylase is controlled by the circulating hepatic bile acid flux.	Bile Acids and Salts	213-222	cytochrome P450 7A1	Oryctolagus cuniculus	141-171
9394736-0	1997	Increased bile acid pool inhibits cholesterol 7 alpha-hydroxylase in cholesterol-fed rabbits.	Bile Acids and Salts	10-19	cytochrome P450 7A1	Oryctolagus cuniculus	34-65
9394736-1	1997	BACKGROUND & AIMS: Cholesterol feeding unexpectedly inhibits cholesterol 7 alpha-hydroxylase in rabbits.	Cholesterol	23-34	cytochrome P450 7A1	Oryctolagus cuniculus	65-96
9394736-4	1997	The activities of hepatic cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase that control bile acid synthesis in classic and alternative pathways were related to the size and composition of bile acid pool.	Bile Acids and Salts	97-106	cytochrome P450 7A1	Oryctolagus cuniculus	26-57
9394736-5	1997	RESULTS: After feeding cholesterol, plasma and hepatic cholesterol concentrations increased, the bile acid pool doubled (from 254 +/- 44 to 533 +/- 51 mg; P < 0.001), cholesterol 7 alpha-hydroxylase activity decreased 68% (P < 0.01), but sterol 27-hydroxylase activity increased 66% (P < 0.05) with increased cholic acid synthesis (P < 0.01).	Cholesterol	23-34	cytochrome P450 7A1	Oryctolagus cuniculus	170-201
9394736-5	1997	RESULTS: After feeding cholesterol, plasma and hepatic cholesterol concentrations increased, the bile acid pool doubled (from 254 +/- 44 to 533 +/- 51 mg; P < 0.001), cholesterol 7 alpha-hydroxylase activity decreased 68% (P < 0.01), but sterol 27-hydroxylase activity increased 66% (P < 0.05) with increased cholic acid synthesis (P < 0.01).	Bile Acids and Salts	97-106	cytochrome P450 7A1	Oryctolagus cuniculus	170-201
9394736-6	1997	Bile drainage in the cholesterol-fed rabbits depleted the bile acid pool and stimulated down-regulated cholesterol 7 alpha-hydroxylase activity 11.4-fold (P < 0.001), although hepatic cholesterol remained elevated.	Cholesterol	21-32	cytochrome P450 7A1	Oryctolagus cuniculus	103-134
9394736-8	1997	CONCLUSIONS: Feeding cholesterol increased hepatic cholesterol and stimulated sterol 27-hydroxylase and alternative bile acid synthesis, which expanded the bile acid pool and inhibited cholesterol 7 alpha-hydroxylase in rabbits.	Cholesterol	21-32	cytochrome P450 7A1	Oryctolagus cuniculus	185-216
7488206-0	1995	Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine.	Cholic Acid	73-84	cytochrome P450 7A1	Oryctolagus cuniculus	39-43
8855192-7	1996	Replacement with exogenous glycodeoxycholic acid increased plasma cholesterol concentrations 1.7 times in NZW rabbits and decreased enhanced cholesterol 7alpha-hydroxylase activity 54%, mRNA levels 86%, cholic acid synthesis 38%, and hepatic LDL receptor-mediated binding 57% in NZW rabbits.	Glycodeoxycholic Acid	27-48	cytochrome P450 7A1	Oryctolagus cuniculus	141-171
8855192-7	1996	Replacement with exogenous glycodeoxycholic acid increased plasma cholesterol concentrations 1.7 times in NZW rabbits and decreased enhanced cholesterol 7alpha-hydroxylase activity 54%, mRNA levels 86%, cholic acid synthesis 38%, and hepatic LDL receptor-mediated binding 57% in NZW rabbits.	Cholic Acid	37-48	cytochrome P450 7A1	Oryctolagus cuniculus	141-171
8855192-8	1996	Bile acid depletion stimulated cholic acid synthesis by up-regulating cholesterol 7alpha-hydroxylase to use cholesterol and reduce plasma concentrations substantially in both NZW and WHHL rabbits, although LDL receptors did not function in WHHL rabbits.	Bile Acids and Salts	0-9	cytochrome P450 7A1	Oryctolagus cuniculus	70-100
8855192-8	1996	Bile acid depletion stimulated cholic acid synthesis by up-regulating cholesterol 7alpha-hydroxylase to use cholesterol and reduce plasma concentrations substantially in both NZW and WHHL rabbits, although LDL receptors did not function in WHHL rabbits.	Cholic Acid	31-42	cytochrome P450 7A1	Oryctolagus cuniculus	70-100
8855192-9	1996	Glycodeoxycholic acid replacement inhibited elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, and hepatic LDL receptor binding to reestablish baseline plasma cholesterol levels in NZW rabbits.	Glycodeoxycholic Acid	0-21	cytochrome P450 7A1	Oryctolagus cuniculus	53-83
8855192-9	1996	Glycodeoxycholic acid replacement inhibited elevated cholesterol 7alpha-hydroxylase, cholic acid synthesis, and hepatic LDL receptor binding to reestablish baseline plasma cholesterol levels in NZW rabbits.	Cholic Acid	10-21	cytochrome P450 7A1	Oryctolagus cuniculus	53-83
8855192-11	1996	Plasma cholesterol concentrations were reduced significantly when cholesterol 7alpha-hydroxylase was stimulated even in the absence of LDL receptor function.	Cholesterol	7-18	cytochrome P450 7A1	Oryctolagus cuniculus	66-96
7488206-0	1995	Different effects on the expression of CYP7 and CYP27 in rabbit liver by cholic acid and cholestyramine.	Cholestyramine Resin	89-103	cytochrome P450 7A1	Oryctolagus cuniculus	39-43
7488206-6	1995	Treatments of rabbits with cholic acid or cholestyramine resulted in marked suppression and induction, respectively, of CYP7 mRNA.	Cholic Acid	27-38	cytochrome P450 7A1	Oryctolagus cuniculus	120-124
7488206-6	1995	Treatments of rabbits with cholic acid or cholestyramine resulted in marked suppression and induction, respectively, of CYP7 mRNA.	Cholestyramine Resin	42-56	cytochrome P450 7A1	Oryctolagus cuniculus	120-124
7492622-5	1995	Combined administration of fluvastatin (50 mg/kg per day) and cholestyramine, a bile acid sequestrant resin, at a level of 2% of the diet for 4 weeks more profoundly decreased plasma total, VLDL- and LDL-cholesterol levels with induction of hepatic cholesterol 7 alpha-hydroxylase and no further induction of the hepatic LDL receptor.	Fluvastatin	27-38	cytochrome P450 7A1	Oryctolagus cuniculus	249-280
7492622-5	1995	Combined administration of fluvastatin (50 mg/kg per day) and cholestyramine, a bile acid sequestrant resin, at a level of 2% of the diet for 4 weeks more profoundly decreased plasma total, VLDL- and LDL-cholesterol levels with induction of hepatic cholesterol 7 alpha-hydroxylase and no further induction of the hepatic LDL receptor.	Cholestyramine Resin	62-76	cytochrome P450 7A1	Oryctolagus cuniculus	249-280
7492622-8	1995	Additional effect of cholestyramine on decrease in plasma cholesterol levels seems to be due to the further decrease in hepatic cholesterol secretion by up-regulation of hepatic cholesterol 7 alpha-hydroxylase.	Cholestyramine Resin	21-35	cytochrome P450 7A1	Oryctolagus cuniculus	178-209
7492622-8	1995	Additional effect of cholestyramine on decrease in plasma cholesterol levels seems to be due to the further decrease in hepatic cholesterol secretion by up-regulation of hepatic cholesterol 7 alpha-hydroxylase.	Cholesterol	128-139	cytochrome P450 7A1	Oryctolagus cuniculus	178-209
8405866-9	1993	(2) GDCA decreased mRNA levels of HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in males, but mRNA levels did not decrease in females.	Glycodeoxycholic Acid	4-8	cytochrome P450 7A1	Oryctolagus cuniculus	56-87
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Tyrosine	122-125	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Lysine	126-129	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Leucine	130-133	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Lysine	134-137	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7544128-2	1995	An anti-peptide antibody targeted to the C-terminus of CYP7 was produced by immunising rabbits with the synthetic peptide Tyr-Lys-Leu-Lys-His.	Histidine	138-141	cytochrome P450 7A1	Oryctolagus cuniculus	55-59
7751825-1	1995	Cholesterol 7 alpha-hydroxylase, the key enzyme in a series of metabolic changes for the production of bile acids from cholesterol, shows circadian rhythms.	Bile Acids and Salts	103-113	cytochrome P450 7A1	Oryctolagus cuniculus	0-31
7751825-1	1995	Cholesterol 7 alpha-hydroxylase, the key enzyme in a series of metabolic changes for the production of bile acids from cholesterol, shows circadian rhythms.	Cholesterol	119-130	cytochrome P450 7A1	Oryctolagus cuniculus	0-31
7751825-3	1995	Because the rabbit is a good animal model for the study of human cholesterol-bile acid metabolism, in the present study we isolated a complete cDNA encoding rabbit cholesterol 7 alpha-hydroxylase (3022 base pairs (bp) long and 1503 bp open-reading frame encoding 501 amino acid residues).	Cholesterol	65-76	cytochrome P450 7A1	Oryctolagus cuniculus	164-195
7751825-3	1995	Because the rabbit is a good animal model for the study of human cholesterol-bile acid metabolism, in the present study we isolated a complete cDNA encoding rabbit cholesterol 7 alpha-hydroxylase (3022 base pairs (bp) long and 1503 bp open-reading frame encoding 501 amino acid residues).	Bile Acids and Salts	77-86	cytochrome P450 7A1	Oryctolagus cuniculus	164-195
7706454-10	1995	Feeding cholesterol to NZW rabbits increased plasma and hepatic concentrations greatly, inhibited LDL receptor-mediated binding, and unexpectedly suppressed cholesterol 7 alpha-hydroxylase activity and mRNA to minimum levels similar to WHHL rabbits.	Cholesterol	8-19	cytochrome P450 7A1	Oryctolagus cuniculus	157-188
8405866-10	1993	(3) Bile acid synthesis was sustained in females because continued biosynthesis of cholesterol provided a substrate for cholesterol 7 alpha-hydroxylase and stimulus for enzyme formation.	Bile Acids and Salts	4-13	cytochrome P450 7A1	Oryctolagus cuniculus	120-151
8405866-10	1993	(3) Bile acid synthesis was sustained in females because continued biosynthesis of cholesterol provided a substrate for cholesterol 7 alpha-hydroxylase and stimulus for enzyme formation.	Cholesterol	83-94	cytochrome P450 7A1	Oryctolagus cuniculus	120-151
8245718-9	1993	The difference in bile acid excretion was also manifest by a higher than normal level of cholesterol 7 alpha-hydroxylase activity and cholesterol 7 alpha-hydroxylase mRNA in the livers from resistant versus normal rabbits.	Bile Acids and Salts	18-27	cytochrome P450 7A1	Oryctolagus cuniculus	89-120
8245718-9	1993	The difference in bile acid excretion was also manifest by a higher than normal level of cholesterol 7 alpha-hydroxylase activity and cholesterol 7 alpha-hydroxylase mRNA in the livers from resistant versus normal rabbits.	Bile Acids and Salts	18-27	cytochrome P450 7A1	Oryctolagus cuniculus	134-165
8245718-10	1993	As cholesterol 7 alpha-hydroxylase is the putative rate-limiting step of bile acid synthesis, we believe that the increased excretion of bile acids by resistant animals is due, at least in part, to increased levels of cholesterol 7 alpha-hydroxylase expression.	Bile Acids and Salts	73-82	cytochrome P450 7A1	Oryctolagus cuniculus	3-34
8245718-10	1993	As cholesterol 7 alpha-hydroxylase is the putative rate-limiting step of bile acid synthesis, we believe that the increased excretion of bile acids by resistant animals is due, at least in part, to increased levels of cholesterol 7 alpha-hydroxylase expression.	Bile Acids and Salts	73-82	cytochrome P450 7A1	Oryctolagus cuniculus	218-249
8245718-10	1993	As cholesterol 7 alpha-hydroxylase is the putative rate-limiting step of bile acid synthesis, we believe that the increased excretion of bile acids by resistant animals is due, at least in part, to increased levels of cholesterol 7 alpha-hydroxylase expression.	Bile Acids and Salts	137-147	cytochrome P450 7A1	Oryctolagus cuniculus	3-34
8245718-10	1993	As cholesterol 7 alpha-hydroxylase is the putative rate-limiting step of bile acid synthesis, we believe that the increased excretion of bile acids by resistant animals is due, at least in part, to increased levels of cholesterol 7 alpha-hydroxylase expression.	Bile Acids and Salts	137-147	cytochrome P450 7A1	Oryctolagus cuniculus	218-249
1568582-5	1992	Hepatic bile acid depletion increased hydroxymethyglutary coenzyme A (HMG-CoA) reductase activity fourfold and cholesterol 7 alpha-hydroxylase activity threefold, which were reduced 48% and 51%, respectively, from their maximum levels during replacement with glycocholic acid.	Bile Acids and Salts	8-17	cytochrome P450 7A1	Oryctolagus cuniculus	111-142
1568582-6	1992	Glycodeoxycholic acid infusion depressed cholesterol 7 alpha-hydroxylase activity by 59% without reducing HMG-CoA reductase activity significantly.	Glycodeoxycholic Acid	0-21	cytochrome P450 7A1	Oryctolagus cuniculus	41-72
1568582-10	1992	Glycocholic acid inhibits both HMG-CoA reductase and cholesterol 7 alpha-hydroxylase while glycodeoxycholic acid affects primarily cholesterol 7 alpha-hydroxylase.	Glycocholic Acid	0-16	cytochrome P450 7A1	Oryctolagus cuniculus	53-84
1568582-10	1992	Glycocholic acid inhibits both HMG-CoA reductase and cholesterol 7 alpha-hydroxylase while glycodeoxycholic acid affects primarily cholesterol 7 alpha-hydroxylase.	Glycodeoxycholic Acid	91-112	cytochrome P450 7A1	Oryctolagus cuniculus	131-162
3719008-8	1986	40% and increased the activity of cholesterol 7 alpha-hydroxylase 2-fold in the cholesterol-fed rabbit compared to cholesterol-fed controls.	Cholesterol	80-91	cytochrome P450 7A1	Oryctolagus cuniculus	34-65
1884884-1	1991	Serum lipoproteins and key hepatic and intestinal enzymes regulating cholesterol synthesis, esterification and catabolism, namely 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, acyl coenzyme A: cholesterol-o-acyltransferase (ACAT) and cholesterol 7 alpha-hydroxylase respectively, were compared in two hypercholesterolaemic rabbit models - the cholesterol-fed animal and the hypercholesterolaemic diabetic animal.	Cholesterol	69-80	cytochrome P450 7A1	Oryctolagus cuniculus	246-277
3427902-4	1987	A comparison of cholesterol synthesis and utilization in alloxan-induced diabetic rats and rabbits revealed that interspecies differences existed only in the response of the key enzymes regulating cholesterol utilization, namely cholesterol 7 alpha-hydroxylase and ACAT in the liver and intestine respectively.	Cholesterol	16-27	cytochrome P450 7A1	Oryctolagus cuniculus	229-260
3427902-4	1987	A comparison of cholesterol synthesis and utilization in alloxan-induced diabetic rats and rabbits revealed that interspecies differences existed only in the response of the key enzymes regulating cholesterol utilization, namely cholesterol 7 alpha-hydroxylase and ACAT in the liver and intestine respectively.	Alloxan	57-64	cytochrome P450 7A1	Oryctolagus cuniculus	229-260
3427902-4	1987	A comparison of cholesterol synthesis and utilization in alloxan-induced diabetic rats and rabbits revealed that interspecies differences existed only in the response of the key enzymes regulating cholesterol utilization, namely cholesterol 7 alpha-hydroxylase and ACAT in the liver and intestine respectively.	Cholesterol	197-208	cytochrome P450 7A1	Oryctolagus cuniculus	229-260
28067465-10	2017	Interestingly, CHO also significantly increased the expression and activity of CYP7A1, as well as IBABP and LDL-R mRNA expressions, but decreased hepatic SHP and BSEP gene expressions.	Cholestyramine Resin	15-18	cytochrome P450 7A1	Oryctolagus cuniculus	79-85
3981265-5	1985	These results suggested that accumulation of cholesterol observed in dystrophic muscle of vitamin E-deficient rabbits may be due to an increase in LDL and VLDL cholesterol, the plasma lipoproteins carrying cholesterol to peripheral tissue, and to a decrease in cholesterol 7 alpha-hydroxylase activity, whose activity may have been affected by the reduced level of cytochrome P-450.	Cholesterol	45-56	cytochrome P450 7A1	Oryctolagus cuniculus	261-292
4019071-2	1985	This hypocholesterolemic effect was accompanied by an increase in hepatic cholesterol-7 alpha-hydroxylase activity and cytochrome P-450 level and by a redistribution of plasma lipoprotein-cholesterol resulting in the elevation of high density to low density lipoprotein-cholesterol ratio.	Cholesterol	9-20	cytochrome P450 7A1	Oryctolagus cuniculus	74-105
31847222-9	2019	The upregulated ACACB, ACLY, LSS, and CYP7A1 genes were found to be inter-related through biological processes of thioester biosynthetic process, acyl-CoA biosynthetic process, acetyl-CoA metabolic process, and others.	Acyl Coenzyme A	146-154	cytochrome P450 7A1	Oryctolagus cuniculus	38-44
31847222-9	2019	The upregulated ACACB, ACLY, LSS, and CYP7A1 genes were found to be inter-related through biological processes of thioester biosynthetic process, acyl-CoA biosynthetic process, acetyl-CoA metabolic process, and others.	Acetyl Coenzyme A	177-187	cytochrome P450 7A1	Oryctolagus cuniculus	38-44
516187-4	1979	Using [7-3N1] cholesterol as a substrate, it established that the activity of cholesterol-7 alpha-hydroxylase, as compared to the initial level, is increased under training and decreased under conditions of low mobility.	[7-3n1] cholesterol	6-25	cytochrome P450 7A1	Oryctolagus cuniculus	78-109
15254889-0	2004	Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.	Bile Acids and Salts	20-29	cytochrome P450 7A1	Oryctolagus cuniculus	134-165
24994853-0	2014	Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits.	Bile Acids and Salts	0-9	cytochrome P450 7A1	Oryctolagus cuniculus	64-70
24994853-2	2014	The present study tested whether portal bile acid flux alone without ileal FGF19 could downregulate CYP7A1 expression in rabbits.	Bile Acids and Salts	40-49	cytochrome P450 7A1	Oryctolagus cuniculus	100-106
24994853-5	2014	Compared with only BF, BF + GDCA (6 h portal perfusion) suppressed CYP7A1 mRNA, whereas BF + GDCA-f (via femoral vein) with the same perfusion rate of GDCA did not show inhibitory effects.	benzo(b)fluoranthene	23-25	cytochrome P450 7A1	Oryctolagus cuniculus	67-73
24994853-5	2014	Compared with only BF, BF + GDCA (6 h portal perfusion) suppressed CYP7A1 mRNA, whereas BF + GDCA-f (via femoral vein) with the same perfusion rate of GDCA did not show inhibitory effects.	Glycodeoxycholic Acid	28-32	cytochrome P450 7A1	Oryctolagus cuniculus	67-73
24994853-5	2014	Compared with only BF, BF + GDCA (6 h portal perfusion) suppressed CYP7A1 mRNA, whereas BF + GDCA-f (via femoral vein) with the same perfusion rate of GDCA did not show inhibitory effects.	benzo(b)fluoranthene	23-25	cytochrome P450 7A1	Oryctolagus cuniculus	67-73
24994853-7	2014	This study demonstrated that portal bile acid flux alone downregulated CYP7A1 expression with diminished FGF19 expression and protein levels, whereas the same bile acid flux reaching the liver through the hepatic artery via femoral vein had no inhibitory effect on CYP7A1.	Bile Acids and Salts	36-45	cytochrome P450 7A1	Oryctolagus cuniculus	71-77
24994853-8	2014	We propose that bile acid flux through the portal venous system may be a kind of "intestinal factor" that suppresses CYP7A1 expression.	Bile Acids and Salts	16-25	cytochrome P450 7A1	Oryctolagus cuniculus	117-123
20456844-18	2010	3 can up-regulate the expression of CYP7A1 mRNA, raise the activity of CYP7A1, and inhibit the expressions of BSEP and SHP mRNAs to regulate the metabolism of total cholesterol in rabbits.	Cholesterol	165-176	cytochrome P450 7A1	Oryctolagus cuniculus	36-42
20456844-18	2010	3 can up-regulate the expression of CYP7A1 mRNA, raise the activity of CYP7A1, and inhibit the expressions of BSEP and SHP mRNAs to regulate the metabolism of total cholesterol in rabbits.	Cholesterol	165-176	cytochrome P450 7A1	Oryctolagus cuniculus	71-77
15386586-1	2004	Alternative HPLC and solid-phase extraction column methods were developed to separate metabolites of enzymes involved in cholesterol metabolism in rabbit liver microsomes: hydroxyl-methylglutaryl-CoA reductase, cholesterol-7alpha-hydroxylase and acyl-CoA:cholesterol acyltransferase.	Cholesterol	121-132	cytochrome P450 7A1	Oryctolagus cuniculus	211-241
16489206-1	2006	The transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1) is greatly decreased in cholesterol-fed rabbits.	Cholesterol	25-36	cytochrome P450 7A1	Oryctolagus cuniculus	62-68
16489206-7	2006	Thus, downregulation of CYP7A1 in cholesterol-fed rabbits is attributable secondarily to the activation of farnesoid X receptor, which increases SHP expression to override the positive effects of LXRalpha.	Cholesterol	34-45	cytochrome P450 7A1	Oryctolagus cuniculus	24-30
15254889-0	2004	Inhibition of ileal bile acid transport lowers plasma cholesterol levels by inactivating hepatic farnesoid X receptor and stimulating cholesterol 7 alpha-hydroxylase.	Cholesterol	54-65	cytochrome P450 7A1	Oryctolagus cuniculus	134-165
15254889-8	2004	Rabbits treated with SC-435 developed ileal bile acid malabsorption, which decreased the return of bile acids (FXR ligands) to the liver to inactivate hepatic FXR, which upregulated CYP7A1 and lowered plasma cholesterol levels.	1-(4-(4-(3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl)phenoxy)butyl)-4-aza-1-azoniabicyclo(2.2.2)octane	21-27	cytochrome P450 7A1	Oryctolagus cuniculus	182-188
14681840-2	2004	The aim of the current study was to ascertain whether the level of this oxysterol reflects hepatic cholesterol 7alpha-hydroxylase activity when plasma cholesterol concentrations are markedly changed.	Oxysterols	72-81	cytochrome P450 7A1	Oryctolagus cuniculus	99-129
14681840-10	2004	In conclusion, plasma 7alpha-hydroxy-4-cholesten-3-one concentrations reflected hepatic cholesterol 7alpha-hydroxylase activities when the sterol levels were adjusted to plasma cholesterol concentrations in rabbits with hypercholesterolemia.	7 alpha-hydroxy-4-cholesten-3-one	22-54	cytochrome P450 7A1	Oryctolagus cuniculus	88-118
14681840-11	2004	The results suggest that plasma 7alpha-hydroxy-4-cholesten-3-one relative to cholesterol is a better marker for hepatic cholesterol 7alpha-hydroxylase activity than the absolute concentration when hypercholesterolemia is present.	7alpha-hydroxy-4-cholesten	32-58	cytochrome P450 7A1	Oryctolagus cuniculus	120-150
14681840-11	2004	The results suggest that plasma 7alpha-hydroxy-4-cholesten-3-one relative to cholesterol is a better marker for hepatic cholesterol 7alpha-hydroxylase activity than the absolute concentration when hypercholesterolemia is present.	Cholesterol	77-88	cytochrome P450 7A1	Oryctolagus cuniculus	120-150
12897188-0	2003	FXR-mediated down-regulation of CYP7A1 dominates LXRalpha in long-term cholesterol-fed NZW rabbits.	Cholesterol	71-82	cytochrome P450 7A1	Oryctolagus cuniculus	32-38
12897188-1	2003	We investigated how cholesterol feeding regulates cholesterol 7alpha-hydroxylase (CYP7A1) via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor alpha (LXRalpha) in New Zealand white rabbits.	Cholesterol	20-31	cytochrome P450 7A1	Oryctolagus cuniculus	82-88
12897188-11	2003	After 10 days of cholesterol feeding, the bile acid (FXR ligand) pool size increased, which activated FXR and inhibited CYP7A1 despite continued activation of LXRalpha.	Cholesterol	17-28	cytochrome P450 7A1	Oryctolagus cuniculus	120-126
12897188-11	2003	After 10 days of cholesterol feeding, the bile acid (FXR ligand) pool size increased, which activated FXR and inhibited CYP7A1 despite continued activation of LXRalpha.	Bile Acids and Salts	42-51	cytochrome P450 7A1	Oryctolagus cuniculus	120-126
12401785-4	2002	Replacing the enterohepatic bile acid pool with DCA restored FXR mRNA and nuclear protein levels and activated FXR-mediated transcription as evidenced by the increased expression of its target genes, SHP and BSEP, and decreased CYP7A1 mRNA level and activity.	Bile Acids and Salts	28-37	cytochrome P450 7A1	Oryctolagus cuniculus	228-234
12850506-4	2003	Enzymes involved in cholesterol metabolism (ACAT, HMG-CoA-reductase and cholesterol-7alpha-hydroxylase) are greatly influenced by cholesterol profile.	Cholesterol	20-31	cytochrome P450 7A1	Oryctolagus cuniculus	72-102
12401785-4	2002	Replacing the enterohepatic bile acid pool with DCA restored FXR mRNA and nuclear protein levels and activated FXR-mediated transcription as evidenced by the increased expression of its target genes, SHP and BSEP, and decreased CYP7A1 mRNA level and activity.	Deoxycholic Acid	48-51	cytochrome P450 7A1	Oryctolagus cuniculus	228-234
11792721-0	2002	Removal of the bile acid pool upregulates cholesterol 7alpha-hydroxylase by deactivating FXR in rabbits.	Bile Acids and Salts	15-24	cytochrome P450 7A1	Oryctolagus cuniculus	42-72
11792721-6	2002	The data, taken together, indicate that FXR was deactivated when the bile acid pool was depleted such that CYP7A1 was upregulated.	Bile Acids and Salts	69-78	cytochrome P450 7A1	Oryctolagus cuniculus	107-113