PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
18834848-1	2008	Acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) is a key enzyme in triacylglycerol synthesis, and inhibiting this enzyme is a promising approach for treating obesity, type II diabetes, and dyslipidemia.	Triglycerides	73-88	diacylglycerol O-acyltransferase 1	Homo sapiens	48-52
18937486-1	2008	Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT), which is a key enzyme in triglyceride synthesis in eukaryotic organisms, has been proposed as one of the drug targets for treating obesity, type II diabetes mellitus, and metabolic syndrome.	Triglycerides	87-99	diacylglycerol O-acyltransferase 1	Homo sapiens	14-53
18937486-1	2008	Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT), which is a key enzyme in triglyceride synthesis in eukaryotic organisms, has been proposed as one of the drug targets for treating obesity, type II diabetes mellitus, and metabolic syndrome.	Triglycerides	87-99	diacylglycerol O-acyltransferase 1	Homo sapiens	55-59
18768481-0	2008	Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1).	Glycerides	13-26	diacylglycerol O-acyltransferase 1	Homo sapiens	80-85
18768481-3	2008	Recently, it was found that, in addition to acylating diacylglycerol (DAG), DGAT1 also possesses robust enzymatic activity for acylating monoacylglycerol (MAG) (Yen, C. L., Monetti, M., Burri, B. J., and Farese, R. V., Jr. (2005) J. Lipid Res.	Diglycerides	54-68	diacylglycerol O-acyltransferase 1	Homo sapiens	76-81
18768481-3	2008	Recently, it was found that, in addition to acylating diacylglycerol (DAG), DGAT1 also possesses robust enzymatic activity for acylating monoacylglycerol (MAG) (Yen, C. L., Monetti, M., Burri, B. J., and Farese, R. V., Jr. (2005) J. Lipid Res.	Diglycerides	70-73	diacylglycerol O-acyltransferase 1	Homo sapiens	76-81
18768481-3	2008	Recently, it was found that, in addition to acylating diacylglycerol (DAG), DGAT1 also possesses robust enzymatic activity for acylating monoacylglycerol (MAG) (Yen, C. L., Monetti, M., Burri, B. J., and Farese, R. V., Jr. (2005) J. Lipid Res.	Monoglycerides	137-153	diacylglycerol O-acyltransferase 1	Homo sapiens	76-81
18768481-6	2008	Enzymatically, we found that triacylglycerol (TAG) synthesis from MAG by DGAT1 does not behave according to classic Michaelis-Menten kinetics.	Triglycerides	29-44	diacylglycerol O-acyltransferase 1	Homo sapiens	73-78
18768481-7	2008	At low concentrations of 2-MAG (<50 microm), the major acylation product by DGAT1 was TAG; however, increased concentrations of 2-MAG (50-200 microm) resulted in decreased TAG formation.	2-mag	25-30	diacylglycerol O-acyltransferase 1	Homo sapiens	79-84
18768481-9	2008	We have also found that XP620 is an inhibitor that selectively inhibits the acylation of MAG by DGAT1 (IC(50) of human DGAT1: 16.6+/-4.0 nM (MAG as substrate) and 1499+/-318 nM (DAG as substrate); IC(50) values of human DGAT2, MGAT2, and MGAT3 are >30,000 nM).	Monoglycerides	89-92	diacylglycerol O-acyltransferase 1	Homo sapiens	96-101
18768481-9	2008	We have also found that XP620 is an inhibitor that selectively inhibits the acylation of MAG by DGAT1 (IC(50) of human DGAT1: 16.6+/-4.0 nM (MAG as substrate) and 1499+/-318 nM (DAG as substrate); IC(50) values of human DGAT2, MGAT2, and MGAT3 are >30,000 nM).	Monoglycerides	89-92	diacylglycerol O-acyltransferase 1	Homo sapiens	119-124
18768481-9	2008	We have also found that XP620 is an inhibitor that selectively inhibits the acylation of MAG by DGAT1 (IC(50) of human DGAT1: 16.6+/-4.0 nM (MAG as substrate) and 1499+/-318 nM (DAG as substrate); IC(50) values of human DGAT2, MGAT2, and MGAT3 are >30,000 nM).	Diglycerides	178-181	diacylglycerol O-acyltransferase 1	Homo sapiens	96-101
18768481-14	2008	Based on these data, we conclude that the acylation of acylglycerols by DGAT1 is important for dietary fat absorption in the intestine.	Glycerides	55-68	diacylglycerol O-acyltransferase 1	Homo sapiens	72-77
18508126-4	2008	The two major enzymes that have DGAT activity appear to have specialised functions, that are most evident in triglyceride-secreting tissues.	Triglycerides	109-121	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
17907060-2	2007	Diacylglycerol acyltransferase (DGAT) catalyzes the final reaction of triacylgycerol synthesis.	triacylgycerol	70-84	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
17907060-2	2007	Diacylglycerol acyltransferase (DGAT) catalyzes the final reaction of triacylgycerol synthesis.	triacylgycerol	70-84	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
17905705-1	2007	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipids.	glycerolipids	130-143	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
17905705-1	2007	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme that plays a central role in the metabolism of cellular glycerolipids.	glycerolipids	130-143	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
17905705-2	2007	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1.	Triglycerides	33-48	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-2	2007	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1.	diacylgycerol	82-95	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-2	2007	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1.	dag	97-100	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-2	2007	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycero1.	triacylglycero1	139-154	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-3	2007	DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation.	Diglycerides	60-74	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-3	2007	DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation.	Triglycerides	149-164	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
17905705-4	2007	Therefore, DGAT is not only an key factor for control triglycerides and fatty acids, but also may play a key modulatory role in animal fat deposition.	Triglycerides	54-67	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
17905705-4	2007	Therefore, DGAT is not only an key factor for control triglycerides and fatty acids, but also may play a key modulatory role in animal fat deposition.	Fatty Acids	72-83	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
17592768-2	2007	Diacylglycerol acyltransferase (DGAT1) is considered the key enzyme in controlling the rate of synthesis of triglycerides.	Triglycerides	108-121	diacylglycerol O-acyltransferase 1	Homo sapiens	32-37
17592768-9	2007	The SNP (C/T) detected at position 11785 in exon 17 creates a substitution change for the amino acid sequence, resulting in an Ala residue (GCG) transition to a Val residue (GTG) in position 484 of buffalo DGAT1 protein.	Alanine	127-130	diacylglycerol O-acyltransferase 1	Homo sapiens	206-211
17592768-9	2007	The SNP (C/T) detected at position 11785 in exon 17 creates a substitution change for the amino acid sequence, resulting in an Ala residue (GCG) transition to a Val residue (GTG) in position 484 of buffalo DGAT1 protein.	gallocatechin gallate	140-143	diacylglycerol O-acyltransferase 1	Homo sapiens	206-211
17592768-9	2007	The SNP (C/T) detected at position 11785 in exon 17 creates a substitution change for the amino acid sequence, resulting in an Ala residue (GCG) transition to a Val residue (GTG) in position 484 of buffalo DGAT1 protein.	Valine	161-164	diacylglycerol O-acyltransferase 1	Homo sapiens	206-211
17592768-9	2007	The SNP (C/T) detected at position 11785 in exon 17 creates a substitution change for the amino acid sequence, resulting in an Ala residue (GCG) transition to a Val residue (GTG) in position 484 of buffalo DGAT1 protein.	Guanosine Triphosphate	174-177	diacylglycerol O-acyltransferase 1	Homo sapiens	206-211
17269553-0	2006	Diacylglycerol acyltransferase: a key mediator of plant triacylglycerol synthesis.	Triglycerides	56-71	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
17269553-6	2006	TAG can also be formed in plants via two different acyl-CoA-independent pathways, catalyzed by phospholipid: diacylglycerol acyltransferase and diacylglycerol transacylase.	Phospholipids	95-107	diacylglycerol O-acyltransferase 1	Homo sapiens	109-139
16448557-3	2006	Acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two DGAT enzymes that catalyze the final reaction in the known pathways of mammalian triglyceride synthesis.	Triglycerides	145-157	diacylglycerol O-acyltransferase 1	Homo sapiens	43-48
16459663-2	2005	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol.	Triglycerides	33-48	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
16459663-2	2005	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol.	diacylgycerol	82-95	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
16459663-2	2005	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol.	dag	97-100	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
16459663-2	2005	DGAT catalyzes the final step in triacylglycerol (TAG) biosynthesis by converting diacylgycerol (DAG) and fatty acyl-coenzyme A (CoA) into triacylglycerol.	Triglycerides	139-154	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
16214399-1	2005	We provide biochemical evidence that enzymes involved in the synthesis of triacylglycerol, namely acyl coenzyme A:diacylglycerol acyltransferase (DGAT) and acyl coenzyme A:monoacylglycerol acyltransferase (MGAT), are capable of carrying out the acyl coenzyme A:retinol acyltransferase (ARAT) reaction.	Triglycerides	74-89	diacylglycerol O-acyltransferase 1	Homo sapiens	146-150
16214399-1	2005	We provide biochemical evidence that enzymes involved in the synthesis of triacylglycerol, namely acyl coenzyme A:diacylglycerol acyltransferase (DGAT) and acyl coenzyme A:monoacylglycerol acyltransferase (MGAT), are capable of carrying out the acyl coenzyme A:retinol acyltransferase (ARAT) reaction.	Triglycerides	74-89	diacylglycerol O-acyltransferase 1	Homo sapiens	286-290
16214399-3	2005	The apparent K(m) values of recombinant DGAT1/ARAT for retinol and palmitoyl coenzyme A were determined to be 25.9+/-2.1 microM and 13.9+/-0.3 microM, respectively, both of which are similar to the values previously determined for ARAT in native tissues.	Vitamin A	55-62	diacylglycerol O-acyltransferase 1	Homo sapiens	40-45
16214399-3	2005	The apparent K(m) values of recombinant DGAT1/ARAT for retinol and palmitoyl coenzyme A were determined to be 25.9+/-2.1 microM and 13.9+/-0.3 microM, respectively, both of which are similar to the values previously determined for ARAT in native tissues.	Vitamin A	55-62	diacylglycerol O-acyltransferase 1	Homo sapiens	46-50
16214399-3	2005	The apparent K(m) values of recombinant DGAT1/ARAT for retinol and palmitoyl coenzyme A were determined to be 25.9+/-2.1 microM and 13.9+/-0.3 microM, respectively, both of which are similar to the values previously determined for ARAT in native tissues.	Vitamin A	55-62	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
16214399-4	2005	A novel selective DGAT1 inhibitor, XP620, inhibits recombinant DGAT1/ARAT at the retinol recognition site.	Vitamin A	81-88	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
16214399-4	2005	A novel selective DGAT1 inhibitor, XP620, inhibits recombinant DGAT1/ARAT at the retinol recognition site.	Vitamin A	81-88	diacylglycerol O-acyltransferase 1	Homo sapiens	63-68
16214399-4	2005	A novel selective DGAT1 inhibitor, XP620, inhibits recombinant DGAT1/ARAT at the retinol recognition site.	Vitamin A	81-88	diacylglycerol O-acyltransferase 1	Homo sapiens	69-73
16214399-7	2005	Using this inhibitor, we estimate that approximately 64% of total retinyl ester formation occurs via DGAT1/ARAT.	Retinyl ester	66-79	diacylglycerol O-acyltransferase 1	Homo sapiens	101-106
16214399-7	2005	Using this inhibitor, we estimate that approximately 64% of total retinyl ester formation occurs via DGAT1/ARAT.	Retinyl ester	66-79	diacylglycerol O-acyltransferase 1	Homo sapiens	107-111
16214399-8	2005	These studies suggest that DGAT1/ARAT is the major enzyme involved in retinyl ester synthesis in Caco-2 cells.	Retinyl ester	70-83	diacylglycerol O-acyltransferase 1	Homo sapiens	27-32
16214399-8	2005	These studies suggest that DGAT1/ARAT is the major enzyme involved in retinyl ester synthesis in Caco-2 cells.	Retinyl ester	70-83	diacylglycerol O-acyltransferase 1	Homo sapiens	33-37
15882263-9	2005	RESULTS: Antimycin A up-regulated multiple determinants of HK-2 cell triglyceride formation, including FATP2, FAS, DGAT1, and DGAT2 (proteins and/or mRNAs).	Antimycin A	9-20	diacylglycerol O-acyltransferase 1	Homo sapiens	115-120
15820137-3	2005	The present study aimed at characterising three key lipogenic enzymes involved in the biosynthesis of triacylglycerol (TAG) and phosphatidylcholine (PC) in Atlantic salmon enterocytes: monoacylglycerol acyltransferase (MGAT), diacylglycerol acyltransferase (DGAT), and diacylglycerol cholinephosphotransferase (CPT).	Triglycerides	102-117	diacylglycerol O-acyltransferase 1	Homo sapiens	258-262
15671038-3	2005	The human acyl-CoA:diacylglycerol acyltransferase (DGAT) 2 gene superfamily comprises seven members, four of which have been previously implicated in the synthesis of di- or triacylglycerol.	di- or triacylglycerol	167-189	diacylglycerol O-acyltransferase 1	Homo sapiens	10-49
15569818-2	2005	Acyl coenzyme A (CoA):diacylglycerol acyltransferase 1 (DGAT1) is 1 of 2 DGAT enzymes that catalyze the final reaction in the known pathways of mammalian triglyceride synthesis.	Triglycerides	154-166	diacylglycerol O-acyltransferase 1	Homo sapiens	56-61
15550388-1	2005	Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the final step in mammalian triglyceride synthesis, and their functions are considered to be involved in the mechanisms of obesity, insulin resistance, and leptin resistance.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
15550388-1	2005	Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the final step in mammalian triglyceride synthesis, and their functions are considered to be involved in the mechanisms of obesity, insulin resistance, and leptin resistance.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
15500922-0	2004	On the biogenesis of lipid bodies in ancient eukaryotes: synthesis of triacylglycerols by a Toxoplasma DGAT1-related enzyme.	Triglycerides	70-86	diacylglycerol O-acyltransferase 1	Homo sapiens	103-108
15500922-1	2004	In mammalian cells, the main stored neutral lipids are triacylglycerol and cholesteryl esters, which are produced by two related enzymes, acyl-CoA:diacylglycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferase (ACAT), respectively.	Triglycerides	55-70	diacylglycerol O-acyltransferase 1	Homo sapiens	138-177
15500922-1	2004	In mammalian cells, the main stored neutral lipids are triacylglycerol and cholesteryl esters, which are produced by two related enzymes, acyl-CoA:diacylglycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferase (ACAT), respectively.	Triglycerides	55-70	diacylglycerol O-acyltransferase 1	Homo sapiens	179-183
15500922-1	2004	In mammalian cells, the main stored neutral lipids are triacylglycerol and cholesteryl esters, which are produced by two related enzymes, acyl-CoA:diacylglycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferase (ACAT), respectively.	Cholesterol Esters	75-93	diacylglycerol O-acyltransferase 1	Homo sapiens	138-177
15500922-1	2004	In mammalian cells, the main stored neutral lipids are triacylglycerol and cholesteryl esters, which are produced by two related enzymes, acyl-CoA:diacylglycerol acyltransferase (DGAT) and acyl-CoA:cholesterol acyltransferase (ACAT), respectively.	Cholesterol Esters	75-93	diacylglycerol O-acyltransferase 1	Homo sapiens	179-183
15500922-8	2004	When a Saccharomyces cerevisiae mutant strain lacking neutral lipid production is transformed with TgDGAT1 cDNA, a significant DGAT activity is reconstituted, resulting in triacylglycerol synthesis and biogenesis of cytosolic lipid inclusions, resembling lipid bodies in T. gondii.	Triglycerides	172-187	diacylglycerol O-acyltransferase 1	Homo sapiens	101-105
15500922-11	2004	Our results indicate that parasitic protozoa are also neutral lipid accumulators and illustrate the first example of the existence of a functional DGAT gene in an ancient eukaryote, demonstrating that diacylglycerol esterification is evolutionarily conserved.	Diglycerides	201-215	diacylglycerol O-acyltransferase 1	Homo sapiens	147-151
15308631-3	2004	Overexpression of human DGAT1 in rat hepatoma McA-RH7777 cells resulted in increased synthesis, cellular accumulation, and secretion of TG.	Triglycerides	136-138	diacylglycerol O-acyltransferase 1	Homo sapiens	24-29
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	diacylglycerol O-acyltransferase 1	Homo sapiens	23-53
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	Flavonoids	119-128	diacylglycerol O-acyltransferase 1	Homo sapiens	55-59
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	taxifolin	130-139	diacylglycerol O-acyltransferase 1	Homo sapiens	23-53
15380446-0	2004	Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion.	taxifolin	130-139	diacylglycerol O-acyltransferase 1	Homo sapiens	55-59
15258194-0	2004	Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells.	Niacin	0-6	diacylglycerol O-acyltransferase 1	Homo sapiens	47-52
15258194-3	2004	In this report, using HepG2 cells, we have examined the effect of niacin on the mRNA expression and microsomal activity of diacylglycerol acyltransferase 1 and 2 (DGAT1 and DGAT2), the last committed but distinctly different enzymes for triglyceride synthesis.	Niacin	66-72	diacylglycerol O-acyltransferase 1	Homo sapiens	163-168
15258194-4	2004	Addition of niacin to the DGAT assay reaction mixture dose-dependently (0-3 mM) inhibited DGAT activity by 35-50%, and the IC(50) was found to be 0.1 mM.	Niacin	12-18	diacylglycerol O-acyltransferase 1	Homo sapiens	26-30
15258194-4	2004	Addition of niacin to the DGAT assay reaction mixture dose-dependently (0-3 mM) inhibited DGAT activity by 35-50%, and the IC(50) was found to be 0.1 mM.	Niacin	12-18	diacylglycerol O-acyltransferase 1	Homo sapiens	90-94
15258194-7	2004	A Lineweaver-Burk plot of DGAT inhibition by niacin showed a noncompetitive type of inhibition.	Niacin	45-51	diacylglycerol O-acyltransferase 1	Homo sapiens	26-30
15258194-8	2004	Niacin selectively inhibited DGAT2 but not DGAT1 activity.	Niacin	0-6	diacylglycerol O-acyltransferase 1	Homo sapiens	43-48
15258194-9	2004	Niacin inhibited overt DGAT activity.	Niacin	0-6	diacylglycerol O-acyltransferase 1	Homo sapiens	23-27
15161747-1	2004	Mice that lack acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in mammalian triglyceride synthesis, have decreased adiposity and increased insulin sensitivity.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	20-56
15161747-1	2004	Mice that lack acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), a key enzyme in mammalian triglyceride synthesis, have decreased adiposity and increased insulin sensitivity.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	58-63
15173394-6	2004	The inhibition of TG synthesis was caused by a reduction in diacylglycerol acyltransferase (DGAT) activity, which corresponded to a decrease in DGAT-1 mRNA expression, but not DGAT-2 expression.	Triglycerides	18-20	diacylglycerol O-acyltransferase 1	Homo sapiens	60-90
15173394-6	2004	The inhibition of TG synthesis was caused by a reduction in diacylglycerol acyltransferase (DGAT) activity, which corresponded to a decrease in DGAT-1 mRNA expression, but not DGAT-2 expression.	Triglycerides	18-20	diacylglycerol O-acyltransferase 1	Homo sapiens	92-96
15173394-6	2004	The inhibition of TG synthesis was caused by a reduction in diacylglycerol acyltransferase (DGAT) activity, which corresponded to a decrease in DGAT-1 mRNA expression, but not DGAT-2 expression.	Triglycerides	18-20	diacylglycerol O-acyltransferase 1	Homo sapiens	144-150
14668353-6	2004	DGAT1 was unable to compensate for the absence of DGAT2, supporting the hypothesis that the two enzymes play fundamentally different roles in mammalian triglyceride metabolism.	Triglycerides	152-164	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
15224651-1	2004	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules.	Triglycerides	76-88	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
15224651-1	2004	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules.	Triglycerides	76-88	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
15224651-1	2004	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules.	Triglycerides	90-92	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
15224651-1	2004	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules.	Triglycerides	90-92	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
14557275-0	2003	Overexpression of diacylglycerol acyltransferase-1 reduces phospholipid synthesis, proliferation, and invasiveness in simian virus 40-transformed human lung fibroblasts.	Phospholipids	59-71	diacylglycerol O-acyltransferase 1	Homo sapiens	18-48
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	0-14	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	0-14	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	16-19	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	16-19	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Triglycerides	267-282	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Triglycerides	267-282	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	glycerolipid	363-375	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	glycerolipid	363-375	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	386-389	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Diglycerides	386-389	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Triglycerides	412-427	diacylglycerol O-acyltransferase 1	Homo sapiens	199-229
14557275-1	2003	Diacylglycerol (DAG) is a versatile molecule that participates as substrate in the synthesis of structural and energetic lipids, and acts as the physiological signal that activates protein kinase C. Diacylglycerol acyltransferase (DGAT), the last committed enzyme in triacylglycerol synthesis, could potentially regulate the content and use of both signaling and glycerolipid substrate DAG by converting it into triacylglycerol.	Triglycerides	412-427	diacylglycerol O-acyltransferase 1	Homo sapiens	231-235
14557275-2	2003	To test this hypothesis, we stably overexpressed the DGAT1 mouse gene in human lung SV40-transformed fibroblasts (DGAT cells), which contains high levels of DAG.	Diglycerides	157-160	diacylglycerol O-acyltransferase 1	Homo sapiens	53-57
14557275-3	2003	DGAT cells exhibited a 3.9-fold higher DGAT activity and a 3.2-fold increase in triacylglycerol content, whereas DAG and phosphatidylcholine decreased by 70 and 20%, respectively, compared with empty vector-transfected SV40 cells (Control cells).	Triglycerides	80-95	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phosphatidylcholines	40-59	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phosphatidylcholines	40-59	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	phosphatidylethanolamine	61-85	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	phosphatidylethanolamine	61-85	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Sphingomyelins	91-104	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Sphingomyelins	91-104	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Triglycerides	207-222	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Triglycerides	207-222	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phospholipids	278-291	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
14557275-4	2003	Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids.	Phospholipids	278-291	diacylglycerol O-acyltransferase 1	Homo sapiens	182-186
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	14c]dag	22-29	diacylglycerol O-acyltransferase 1	Homo sapiens	214-218
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	14c]dag	22-29	diacylglycerol O-acyltransferase 1	Homo sapiens	270-274
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Carbon-14	22-25	diacylglycerol O-acyltransferase 1	Homo sapiens	214-218
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Carbon-14	22-25	diacylglycerol O-acyltransferase 1	Homo sapiens	270-274
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Fatty Acids	39-50	diacylglycerol O-acyltransferase 1	Homo sapiens	214-218
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Fatty Acids	39-50	diacylglycerol O-acyltransferase 1	Homo sapiens	270-274
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Triglycerides	145-160	diacylglycerol O-acyltransferase 1	Homo sapiens	214-218
14557275-5	2003	The incorporation of [14C]DAG and [14C]fatty acids released from plasma membrane by additions of either phospholipase C or phospholipase A2 into triacylglycerol was increased by 6.2- and 2.8-fold, respectively, in DGAT cells compared with control cells, indicating that DGAT can attenuate signaling lipids.	Triglycerides	145-160	diacylglycerol O-acyltransferase 1	Homo sapiens	270-274
14652003-3	2003	In addition, expression of mRNA for diacylglycerol acyltransferase (DGAT), a key enzyme in triacylglycerol synthesis, was significantly decreased by lycCRLPs, but not CRLPs.	Triglycerides	91-106	diacylglycerol O-acyltransferase 1	Homo sapiens	36-66
14652003-3	2003	In addition, expression of mRNA for diacylglycerol acyltransferase (DGAT), a key enzyme in triacylglycerol synthesis, was significantly decreased by lycCRLPs, but not CRLPs.	Triglycerides	91-106	diacylglycerol O-acyltransferase 1	Homo sapiens	68-72
14683457-4	2003	A key enzyme in the synthesis of triglycerides is acylCoA: diacylglycerol acyltransferase (DGAT).	Triglycerides	33-46	diacylglycerol O-acyltransferase 1	Homo sapiens	59-89
14683457-4	2003	A key enzyme in the synthesis of triglycerides is acylCoA: diacylglycerol acyltransferase (DGAT).	Triglycerides	33-46	diacylglycerol O-acyltransferase 1	Homo sapiens	91-95
14569040-1	2003	Acyl-coenzyme A, diacylglycerol acyltransferase (DGAT), is a key enzyme involved in adipose-cell triglyceride storage.	Triglycerides	97-109	diacylglycerol O-acyltransferase 1	Homo sapiens	17-47
14569040-1	2003	Acyl-coenzyme A, diacylglycerol acyltransferase (DGAT), is a key enzyme involved in adipose-cell triglyceride storage.	Triglycerides	97-109	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
12888629-4	2003	These effects were associated with octanoate-mediated reductions in the activities of acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) and acetyl CoA carboxylase (ACC).	octanoic acid	35-44	diacylglycerol O-acyltransferase 1	Homo sapiens	91-129
12888629-4	2003	These effects were associated with octanoate-mediated reductions in the activities of acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) and acetyl CoA carboxylase (ACC).	octanoic acid	35-44	diacylglycerol O-acyltransferase 1	Homo sapiens	131-135
12888629-5	2003	Cells pretreated with octanoate had reduced mRNA levels for a number of lipid metabolism genes, including of DGAT, ACC and stearoyl CoA desaturase-1.	octanoic acid	22-31	diacylglycerol O-acyltransferase 1	Homo sapiens	109-113
12730219-10	2003	Using recombinant murine MGAT2 expressed in Escherichia coli, we demonstrated conclusively that MGAT2 also possessed an intrinsic acyl-CoA:diacylglycerol acyltransferase (DGAT) activity, which could provide an alternative pathway for triacylglycerol synthesis in the absence of DGAT.	Triglycerides	234-249	diacylglycerol O-acyltransferase 1	Homo sapiens	171-175
12670046-0	2003	Core structure in roselipins essential for eliciting inhibitory activity against diacylglycerol acyltransferase.	roselipins	18-28	diacylglycerol O-acyltransferase 1	Homo sapiens	81-111
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	roselipins	7-17	diacylglycerol O-acyltransferase 1	Homo sapiens	47-77
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	roselipins	7-17	diacylglycerol O-acyltransferase 1	Homo sapiens	79-83
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	c20 fatty acid	128-142	diacylglycerol O-acyltransferase 1	Homo sapiens	47-77
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	c20 fatty acid	128-142	diacylglycerol O-acyltransferase 1	Homo sapiens	79-83
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	Mannose	144-151	diacylglycerol O-acyltransferase 1	Homo sapiens	47-77
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	Mannose	144-151	diacylglycerol O-acyltransferase 1	Homo sapiens	79-83
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	arabitol	156-166	diacylglycerol O-acyltransferase 1	Homo sapiens	47-77
12670046-1	2003	Fungal roselipins, discovered as inhibitors of diacylglycerol acyltransferase (DGAT), consist of three parts; highly methylated C20 fatty acid, mannose and arabinitol.	arabitol	156-166	diacylglycerol O-acyltransferase 1	Homo sapiens	79-83
12670046-3	2003	Demannnosyl roselipins conserved the DGAT inhibitory activity, but the others lost the activity, indicating that the arabinitoyl fatty acid core is essential for eliciting the activity.	demannnosyl roselipins	0-22	diacylglycerol O-acyltransferase 1	Homo sapiens	37-41
12407108-1	2002	Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) catalyzes the final step of triglyceride synthesis in mammalian cells.	Triglycerides	78-90	diacylglycerol O-acyltransferase 1	Homo sapiens	0-41
12407108-1	2002	Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) catalyzes the final step of triglyceride synthesis in mammalian cells.	Triglycerides	78-90	diacylglycerol O-acyltransferase 1	Homo sapiens	43-48
12407108-11	2002	No significant functional changes were observed when the conserved tyrosine phosphorylation site in hDGAT1 was mutated by a single base pair substitution.	Tyrosine	67-75	diacylglycerol O-acyltransferase 1	Homo sapiens	100-106
12401709-1	2002	Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two DGAT enzymes known to catalyze the final step in mammalian triglyceride synthesis.	Triglycerides	130-142	diacylglycerol O-acyltransferase 1	Homo sapiens	50-55
12204791-2	2002	Using human hepatoblastoma (HepG2) cells, we examined the effect of gemfibrozil on apo B secretion and TG synthesis catalyzed by diacylglycerol acyltransferase (DGAT), primary processes associated with the secretion of LDL.	Gemfibrozil	68-79	diacylglycerol O-acyltransferase 1	Homo sapiens	129-159
12204791-2	2002	Using human hepatoblastoma (HepG2) cells, we examined the effect of gemfibrozil on apo B secretion and TG synthesis catalyzed by diacylglycerol acyltransferase (DGAT), primary processes associated with the secretion of LDL.	Gemfibrozil	68-79	diacylglycerol O-acyltransferase 1	Homo sapiens	161-165
12204791-2	2002	Using human hepatoblastoma (HepG2) cells, we examined the effect of gemfibrozil on apo B secretion and TG synthesis catalyzed by diacylglycerol acyltransferase (DGAT), primary processes associated with the secretion of LDL.	Triglycerides	103-105	diacylglycerol O-acyltransferase 1	Homo sapiens	129-159
12204791-2	2002	Using human hepatoblastoma (HepG2) cells, we examined the effect of gemfibrozil on apo B secretion and TG synthesis catalyzed by diacylglycerol acyltransferase (DGAT), primary processes associated with the secretion of LDL.	Triglycerides	103-105	diacylglycerol O-acyltransferase 1	Homo sapiens	161-165
12204791-4	2002	It decreased oleate-induced stimulation of apo B secretion, suggesting that gemfibrozil-mediated inhibition of apo B secretion may be dependent on the synthesis of TG catalyzed by DGAT.	Gemfibrozil	76-87	diacylglycerol O-acyltransferase 1	Homo sapiens	180-184
12204791-4	2002	It decreased oleate-induced stimulation of apo B secretion, suggesting that gemfibrozil-mediated inhibition of apo B secretion may be dependent on the synthesis of TG catalyzed by DGAT.	Triglycerides	164-166	diacylglycerol O-acyltransferase 1	Homo sapiens	180-184
12204791-5	2002	Pre-incubation of HepG2 cells with gemfibrozil (200-400 micromol/l for 48 h) significantly inhibited microsomal DGAT activity.	Gemfibrozil	35-46	diacylglycerol O-acyltransferase 1	Homo sapiens	112-116
12204791-6	2002	When added directly to the DGAT assay system containing control microsomes, gemfibrozil significantly inhibited the activity of DGAT by 14-25%.	Gemfibrozil	76-87	diacylglycerol O-acyltransferase 1	Homo sapiens	27-31
12204791-6	2002	When added directly to the DGAT assay system containing control microsomes, gemfibrozil significantly inhibited the activity of DGAT by 14-25%.	Gemfibrozil	76-87	diacylglycerol O-acyltransferase 1	Homo sapiens	128-132
12204791-8	2002	The data indicate that gemfibrozil inhibits DGAT activity resulting in decreased synthesis of TG and its availability for apo B lipidation rendering it susceptible to intracellular apo B degradation leading to the decreased secretion.	Gemfibrozil	23-34	diacylglycerol O-acyltransferase 1	Homo sapiens	44-48
12204791-8	2002	The data indicate that gemfibrozil inhibits DGAT activity resulting in decreased synthesis of TG and its availability for apo B lipidation rendering it susceptible to intracellular apo B degradation leading to the decreased secretion.	Triglycerides	94-96	diacylglycerol O-acyltransferase 1	Homo sapiens	44-48
12130553-1	2002	Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known enzymes that catalyze the final step in mammalian triglyceride synthesis.	Triglycerides	127-139	diacylglycerol O-acyltransferase 1	Homo sapiens	50-55
12123490-1	2002	Triglyceride synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferases (DGAT), microsomal enzymes that use diacylglycerol and fatty acyl CoAs as substrates.	Triglycerides	0-12	diacylglycerol O-acyltransferase 1	Homo sapiens	44-79
12123490-1	2002	Triglyceride synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferases (DGAT), microsomal enzymes that use diacylglycerol and fatty acyl CoAs as substrates.	Triglycerides	0-12	diacylglycerol O-acyltransferase 1	Homo sapiens	81-85
12123490-1	2002	Triglyceride synthesis is catalyzed by acyl CoA:diacylglycerol acyltransferases (DGAT), microsomal enzymes that use diacylglycerol and fatty acyl CoAs as substrates.	Diglycerides	48-62	diacylglycerol O-acyltransferase 1	Homo sapiens	81-85
11973306-4	2002	The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG).	Diglycerides	72-86	diacylglycerol O-acyltransferase 1	Homo sapiens	104-108
11973306-4	2002	The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG).	Diglycerides	142-145	diacylglycerol O-acyltransferase 1	Homo sapiens	72-102
11973306-4	2002	The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG).	Diglycerides	142-145	diacylglycerol O-acyltransferase 1	Homo sapiens	104-108
11973306-4	2002	The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG).	Triglycerides	152-167	diacylglycerol O-acyltransferase 1	Homo sapiens	72-102
11973306-4	2002	The midway gene encodes a protein similar to mammalian acyl coenzyme A: diacylglycerol acyltransferase (DGAT), which converts diacylglycerol (DAG) into triacylglycerol (TAG).	Triglycerides	152-167	diacylglycerol O-acyltransferase 1	Homo sapiens	104-108
11956242-1	2002	Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in mammalian triglyceride synthesis.	Triglycerides	132-144	diacylglycerol O-acyltransferase 1	Homo sapiens	50-55
11956242-1	2002	Acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in mammalian triglyceride synthesis.	Triglycerides	132-144	diacylglycerol O-acyltransferase 1	Homo sapiens	50-54
11672446-1	2001	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA.	Triglycerides	110-125	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
11672446-1	2001	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is an integral membrane enzyme that catalyses the last step of triacylglycerol synthesis from diacylglycerol and acyl-CoA.	Acyl Coenzyme A	160-168	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
11481335-1	2001	Studies involving the cloning and disruption of the gene for acyl-CoA:diacylglycerol acyltransferase (DGAT) have shown that alternative mechanisms exist for triglyceride synthesis.	Triglycerides	157-169	diacylglycerol O-acyltransferase 1	Homo sapiens	61-100
11481335-1	2001	Studies involving the cloning and disruption of the gene for acyl-CoA:diacylglycerol acyltransferase (DGAT) have shown that alternative mechanisms exist for triglyceride synthesis.	Triglycerides	157-169	diacylglycerol O-acyltransferase 1	Homo sapiens	102-106
11481335-4	2001	The expression of DGAT2 in insect cells stimulated triglyceride synthesis 6-fold in assays with cellular membranes, and DGAT2 activity was dependent on the presence of fatty acyl-CoA and diacylglycerol, indicating that this protein is a DGAT.	Triglycerides	51-63	diacylglycerol O-acyltransferase 1	Homo sapiens	18-22
11481335-4	2001	The expression of DGAT2 in insect cells stimulated triglyceride synthesis 6-fold in assays with cellular membranes, and DGAT2 activity was dependent on the presence of fatty acyl-CoA and diacylglycerol, indicating that this protein is a DGAT.	Acyl Coenzyme A	168-182	diacylglycerol O-acyltransferase 1	Homo sapiens	18-22
11481335-4	2001	The expression of DGAT2 in insect cells stimulated triglyceride synthesis 6-fold in assays with cellular membranes, and DGAT2 activity was dependent on the presence of fatty acyl-CoA and diacylglycerol, indicating that this protein is a DGAT.	Diglycerides	187-201	diacylglycerol O-acyltransferase 1	Homo sapiens	18-22
11481335-6	2001	DGAT2 activity was inhibited by a high concentration (100 mm) of MgCl(2) in an in vitro assay, a characteristic that distinguishes DGAT2 from DGAT1.	Magnesium Chloride	65-72	diacylglycerol O-acyltransferase 1	Homo sapiens	142-147
10829075-1	2000	Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase.	Triglycerides	0-15	diacylglycerol O-acyltransferase 1	Homo sapiens	171-210
10829075-1	2000	Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase.	Acyl Coenzyme A	73-81	diacylglycerol O-acyltransferase 1	Homo sapiens	171-210
10829075-1	2000	Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase.	Diglycerides	100-114	diacylglycerol O-acyltransferase 1	Homo sapiens	171-210
10829075-1	2000	Triacylglycerol (TAG) is known to be synthesized in a reaction that uses acyl-CoA as acyl donor and diacylglycerol (DAG) as acceptor, and which is catalyzed by the enzyme acyl-CoA:diacylglycerol acyltransferase.	Diglycerides	116-119	diacylglycerol O-acyltransferase 1	Homo sapiens	171-210
10070036-6	1999	The amount of intestinal fatty acid-binding protein (I-FABP), which is thought to be important for fatty acid absorption, and the activity of diacylglycerol acyltransferase (DGAT), an enzyme at the branch point of diacylglycerol utilization, were reduced.	Diglycerides	142-156	diacylglycerol O-acyltransferase 1	Homo sapiens	174-178
10070036-8	1999	This suggests that EGF inhibited palmitate uptake by reducing the I-FABP level and shifted its utilization from triglycerides to phospholipids by inhibiting DGAT.	Palmitates	33-42	diacylglycerol O-acyltransferase 1	Homo sapiens	157-161
9756920-10	1998	Consistent with this hypothesis, ARGP1, unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylation in triglyceride biosynthesis.	Diglycerides	112-126	diacylglycerol O-acyltransferase 1	Homo sapiens	33-38
9756920-10	1998	Consistent with this hypothesis, ARGP1, unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylation in triglyceride biosynthesis.	Triglycerides	194-206	diacylglycerol O-acyltransferase 1	Homo sapiens	33-38
9475289-0	1998	L-glutamine and transforming growth factor-alpha enhance recovery of monoacylglycerol acyltransferase and diacylglycerol acyltransferase activity in porcine postischemic ileum.	Glutamine	0-11	diacylglycerol O-acyltransferase 1	Homo sapiens	106-136
9475289-2	1998	Two intrinsic microsomal enzymes, monoacylglycerol acyltransferase (MGAT) and diacylglycerol acyltransferase (DGAT), catalyze the major pathway for intestinal triacylglycerol biosynthesis.	Triglycerides	159-174	diacylglycerol O-acyltransferase 1	Homo sapiens	78-108
9475289-2	1998	Two intrinsic microsomal enzymes, monoacylglycerol acyltransferase (MGAT) and diacylglycerol acyltransferase (DGAT), catalyze the major pathway for intestinal triacylglycerol biosynthesis.	Triglycerides	159-174	diacylglycerol O-acyltransferase 1	Homo sapiens	110-114
9475289-7	1998	At 72 h, MGAT and DGAT recovery in Gln plus TGF-alpha-treated loops was significantly greater than their corresponding 6-h peak damage levels (p < 0.05).	Glutamine	35-38	diacylglycerol O-acyltransferase 1	Homo sapiens	18-22
9475289-8	1998	From 6 to 72 h, MGAT increased 4-fold and DGAT increased 3.6-fold after Gln plus TGF-alpha treatment.	Glutamine	72-75	diacylglycerol O-acyltransferase 1	Homo sapiens	42-46
9475289-9	1998	With other treatments, MGAT and DGAT activities increased <2.5-fold from 6 to 72 h. This study shows that intestinal MGAT and DGAT activities decrease after ischemic damage, yet recover rapidly in bowel exposed to Gln and/or TGF-alpha.	Glutamine	217-220	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
9475289-9	1998	With other treatments, MGAT and DGAT activities increased <2.5-fold from 6 to 72 h. This study shows that intestinal MGAT and DGAT activities decrease after ischemic damage, yet recover rapidly in bowel exposed to Gln and/or TGF-alpha.	Glutamine	217-220	diacylglycerol O-acyltransferase 1	Homo sapiens	129-133
9366096-2	1997	From DGAT inhibitory activity-guided fractionation, two chalcones were isolated.	Chalcones	56-65	diacylglycerol O-acyltransferase 1	Homo sapiens	5-9
9366096-6	1997	They showed preferential inhibition of triacylglycerol formation in intact Raji cells, indicating that they inhibit DGAT activity preferentially in living cells.	Triglycerides	39-54	diacylglycerol O-acyltransferase 1	Homo sapiens	116-120
8703940-9	1996	However, this results in less favorable binding of Arg-P1 in the oxyanion hole as shown by long hydrogen-bonding distances.	Hydrogen	96-104	diacylglycerol O-acyltransferase 1	Homo sapiens	51-57
8900457-0	1996	A protein tyrosine kinase associated with the ATP-dependent inactivation of adipose diacylglycerol acyltransferase.	Adenosine Triphosphate	46-49	diacylglycerol O-acyltransferase 1	Homo sapiens	84-114
8900457-1	1996	The activity that has been previously reported to reversibly inactivate adipose glycerolphosphate acyltransferase (GPAT) and diacylglycerol acyltransferase (DGAT) in vitro in the presence of ATP is shown here to be partially purified from adipose tissue with an apparent molecular weight of 68 kDa.	Adenosine Triphosphate	191-194	diacylglycerol O-acyltransferase 1	Homo sapiens	125-155
8900457-1	1996	The activity that has been previously reported to reversibly inactivate adipose glycerolphosphate acyltransferase (GPAT) and diacylglycerol acyltransferase (DGAT) in vitro in the presence of ATP is shown here to be partially purified from adipose tissue with an apparent molecular weight of 68 kDa.	Adenosine Triphosphate	191-194	diacylglycerol O-acyltransferase 1	Homo sapiens	157-161
8900457-2	1996	The activity responsible for inactivating DGAT is associated with a kinase activity as determined by phosphate incorporation both into microsomal proteins and into a synthetic tyrosine-containing peptide as substrate for protein tyrosine kinase.	Phosphates	101-110	diacylglycerol O-acyltransferase 1	Homo sapiens	42-46
8900457-4	1996	Both DGAT inactivating and kinase activities assayed from the purified sample have been found to be insensitive to the Ser/Thr kinase inhibitor H-7 while being sensitive to genistein and tyrphostin-25.	Genistein	173-182	diacylglycerol O-acyltransferase 1	Homo sapiens	5-9
8900457-4	1996	Both DGAT inactivating and kinase activities assayed from the purified sample have been found to be insensitive to the Ser/Thr kinase inhibitor H-7 while being sensitive to genistein and tyrphostin-25.	tyrphostin 25	187-200	diacylglycerol O-acyltransferase 1	Homo sapiens	5-9
7592058-8	1995	Amidepsines also showed specific inhibition of triacylglycerol formation in intact Raji cells, indicating that they inhibit DGAT activity in living cells.	amidepsines	0-11	diacylglycerol O-acyltransferase 1	Homo sapiens	124-128
27519880-4	1993	As the inhibition of DGAT activity by Triton X-100 was overcome by the addition of diacylglycerol (DG), the dependency of DGAT activity on exogenous DG was determined in the presence of 0.1% Triton X-100.	Octoxynol	38-50	diacylglycerol O-acyltransferase 1	Homo sapiens	21-25
27519880-4	1993	As the inhibition of DGAT activity by Triton X-100 was overcome by the addition of diacylglycerol (DG), the dependency of DGAT activity on exogenous DG was determined in the presence of 0.1% Triton X-100.	Diglycerides	83-97	diacylglycerol O-acyltransferase 1	Homo sapiens	21-25
27519880-4	1993	As the inhibition of DGAT activity by Triton X-100 was overcome by the addition of diacylglycerol (DG), the dependency of DGAT activity on exogenous DG was determined in the presence of 0.1% Triton X-100.	Octoxynol	191-203	diacylglycerol O-acyltransferase 1	Homo sapiens	122-126
27519880-5	1993	DGAT activity in the membrane fraction was traced in fungi cultured for different time periods or in media at different carbon to nitrogen (C/N) ratios.	Carbon	120-126	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
27519880-5	1993	DGAT activity in the membrane fraction was traced in fungi cultured for different time periods or in media at different carbon to nitrogen (C/N) ratios.	Nitrogen	130-138	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
27519880-5	1993	DGAT activity in the membrane fraction was traced in fungi cultured for different time periods or in media at different carbon to nitrogen (C/N) ratios.	Carbon	140-141	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
27519880-5	1993	DGAT activity in the membrane fraction was traced in fungi cultured for different time periods or in media at different carbon to nitrogen (C/N) ratios.	Nitrogen	142-143	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
2366629-4	1990	AcylCoA:cholesterol acyltransferase (ACAT) and diacylglycerol acyltransferase (DGAT) activities measured on cell-free extracts appeared to be decreased also by phospholipid polar head group modification, whereas the overall phospholipid acyltransferase activity remained unchanged.	Phospholipids	160-172	diacylglycerol O-acyltransferase 1	Homo sapiens	47-77
2366629-4	1990	AcylCoA:cholesterol acyltransferase (ACAT) and diacylglycerol acyltransferase (DGAT) activities measured on cell-free extracts appeared to be decreased also by phospholipid polar head group modification, whereas the overall phospholipid acyltransferase activity remained unchanged.	Phospholipids	160-172	diacylglycerol O-acyltransferase 1	Homo sapiens	79-83
33235909-1	2020	We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth.	Fatty Acids	145-156	diacylglycerol O-acyltransferase 1	Homo sapiens	86-120
33235909-1	2020	We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth.	Fatty Acids	145-156	diacylglycerol O-acyltransferase 1	Homo sapiens	122-127
33235909-1	2020	We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth.	Triglycerides	162-175	diacylglycerol O-acyltransferase 1	Homo sapiens	86-120
33235909-1	2020	We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth.	Triglycerides	162-175	diacylglycerol O-acyltransferase 1	Homo sapiens	122-127
34757839-7	2022	DGAT1/2 could elevate cellular triglycerides synthesis and ultimately promote intracellular LD formation.	Triglycerides	31-44	diacylglycerol O-acyltransferase 1	Homo sapiens	0-7
34757839-12	2022	Then NDRG1 elevated cellular triglycerides synthesis by increasing the activity of diacylglycerol acyltransferase 1/2 (DGAT1/2), which promotes the biogenesis of LDs.	Triglycerides	29-42	diacylglycerol O-acyltransferase 1	Homo sapiens	119-126
34884755-8	2021	Interestingly, ANGPTL8 inhibited steatosis and expression of lipogenic factors (PPARG2, SREBF1, MOGAT2 and DGAT1) in palmitate-treated human hepatocytes.	Palmitates	117-126	diacylglycerol O-acyltransferase 1	Homo sapiens	107-112
34785957-6	2021	Results: A six ARG-based signature, including CLU, DGAT1, MXI1, NFKBI, PIK3CA and PLAU, was developed in the TCGA cohort and significantly stratified patients into low- and high-risk groups.	Arginine	15-18	diacylglycerol O-acyltransferase 1	Homo sapiens	51-56
34740033-11	2021	Expression of genes VLCAD and DGAT1, involved in fatty acid oxidation as well as DGAT1 in TAG synthesis, were significantly elevated after each cycle, whereas expression of genes ELOVL2 and FADS2, involved in fatty acid elongation and desaturation were significantly lower at D9 compared to D2 and D0 (P < 0.03).	Fatty Acids	49-59	diacylglycerol O-acyltransferase 1	Homo sapiens	30-35
34702802-6	2021	Importantly, a cheap and orally available DGAT inhibitor, xanthohumol, was found to suppress SARS-CoV-2 replication and the associated pulmonary inflammation in a hamster model.	xanthohumol	58-69	diacylglycerol O-acyltransferase 1	Homo sapiens	42-46
34116261-1	2021	In eukaryotic organisms, two unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, catalyze the final step of the triacylglycerol biosynthetic pathway.	Triglycerides	143-158	diacylglycerol O-acyltransferase 1	Homo sapiens	39-78
34116261-1	2021	In eukaryotic organisms, two unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, catalyze the final step of the triacylglycerol biosynthetic pathway.	Triglycerides	143-158	diacylglycerol O-acyltransferase 1	Homo sapiens	80-84
34116261-1	2021	In eukaryotic organisms, two unrelated acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, catalyze the final step of the triacylglycerol biosynthetic pathway.	Triglycerides	143-158	diacylglycerol O-acyltransferase 1	Homo sapiens	95-100
34160713-1	2021	DGAT1 plays a crucial controlling role in triglyceride biosynthetic pathways, which makes it an attractive therapeutic target for obesity.	Triglycerides	42-54	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Triglycerides	58-71	diacylglycerol O-acyltransferase 1	Homo sapiens	0-34
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Triglycerides	58-71	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Acyl Coenzyme A	88-96	diacylglycerol O-acyltransferase 1	Homo sapiens	0-34
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Acyl Coenzyme A	88-96	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Diglycerides	100-114	diacylglycerol O-acyltransferase 1	Homo sapiens	0-34
34095320-5	2021	Diacylglycerol O-acyltransferase 1 (DGAT1) can synthesize triglycerides by transferring acyl-CoA to diacylglycerol, which plays a key role in lipid synthesis.	Diglycerides	100-114	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
34095320-9	2021	GSEA was used to analyze the KEGG pathways and biological function enriched because of DGAT1 expression in ovarian cancer.	gsea	0-4	diacylglycerol O-acyltransferase 1	Homo sapiens	87-92
34095320-13	2021	In addition, GSEA showed that DGAT1 may be involved in the immune process.	gsea	13-17	diacylglycerol O-acyltransferase 1	Homo sapiens	30-35
35549216-4	2022	Acylation occurred in two stages: (i) proton transfer from Ser441 to His296 concerted with the nucleophilic attack of Ser441 to the substrate"s P1-Arg and (ii) proton transfer from His296 to the P1"-Ser residue concerted with the cleavage of the ArgP1-SerP1" peptide bond, with a Gibbs activation energy of 17.1 and 15.8 kcal mol-1, relative to the reactant.	Arginine	147-150	diacylglycerol O-acyltransferase 1	Homo sapiens	246-251
35549216-4	2022	Acylation occurred in two stages: (i) proton transfer from Ser441 to His296 concerted with the nucleophilic attack of Ser441 to the substrate"s P1-Arg and (ii) proton transfer from His296 to the P1"-Ser residue concerted with the cleavage of the ArgP1-SerP1" peptide bond, with a Gibbs activation energy of 17.1 and 15.8 kcal mol-1, relative to the reactant.	Serine	199-202	diacylglycerol O-acyltransferase 1	Homo sapiens	246-251
35411952-0	2022	DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion.	Iron	87-91	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
35411952-6	2022	DGAT1-dependent lipid droplet biosynthesis occurred several hours before mitochondrial clearance, with lipid droplets bordering mitochondria upon iron chelation.	Iron	146-150	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
35322811-10	2022	Additionally, we demonstrated that the MGAT activity of DGAT1 only makes a minor contribution to TG synthesis in intact HepG2 cells.	Thioguanine	97-99	diacylglycerol O-acyltransferase 1	Homo sapiens	56-61
35102546-7	2022	Increased oil content under SD was attributed to the high phosphoenolpyruvate carboxylase (PEPCase, EC 4.1.1.31), acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) and diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) activities, whereas the opposite effects were seen under ET.	Oils	10-13	diacylglycerol O-acyltransferase 1	Homo sapiens	162-192
35102546-7	2022	Increased oil content under SD was attributed to the high phosphoenolpyruvate carboxylase (PEPCase, EC 4.1.1.31), acetyl-CoA carboxylase (ACCase, EC 6.4.1.2) and diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) activities, whereas the opposite effects were seen under ET.	Oils	10-13	diacylglycerol O-acyltransferase 1	Homo sapiens	194-198
3311005-5	1987	Additional regulatory steps in triglyceride formation are the reactions catalyzed by the microsomal phosphatidic acid phosphatase and diglyceride acyltransferase.	Triglycerides	31-43	diacylglycerol O-acyltransferase 1	Homo sapiens	134-161
6516908-1	1984	Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT).	Vitamin A	45-52	diacylglycerol O-acyltransferase 1	Homo sapiens	167-201
6516908-1	1984	Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT).	Vitamin A	45-52	diacylglycerol O-acyltransferase 1	Homo sapiens	203-207
6516908-3	1984	At optimal incubation conditions the rate of retinyl ester formation due to ARAT (0.37 +/- 0.31 nmole ester formed X mg microsomal protein-1 X minute-1, mean +/- SD, n = 6) suggests that the enzyme is of physiological importance.	Retinyl ester	45-58	diacylglycerol O-acyltransferase 1	Homo sapiens	76-80
6516908-3	1984	At optimal incubation conditions the rate of retinyl ester formation due to ARAT (0.37 +/- 0.31 nmole ester formed X mg microsomal protein-1 X minute-1, mean +/- SD, n = 6) suggests that the enzyme is of physiological importance.	Esters	53-58	diacylglycerol O-acyltransferase 1	Homo sapiens	76-80
6853505-0	1983	Medium chain fatty acids as specific substrates for diglyceride acyltransferase in cultured hepatocytes.	medium chain fatty acids	0-24	diacylglycerol O-acyltransferase 1	Homo sapiens	52-79
6853505-3	1983	On the other hand, octanoic and decanoic acids may serve as substrates for the diglyceride acyltransferase.	octanoic	19-27	diacylglycerol O-acyltransferase 1	Homo sapiens	79-106
6853505-3	1983	On the other hand, octanoic and decanoic acids may serve as substrates for the diglyceride acyltransferase.	Decanoic Acids	32-46	diacylglycerol O-acyltransferase 1	Homo sapiens	79-106
6853505-5	1983	The availability of octanoate as a specific substrate for the diglyceride acyltransferase reaction in cultured hepatocytes enables the measurement of this activity in situ under conditions of overall triglyceride synthesis.	octanoic acid	20-29	diacylglycerol O-acyltransferase 1	Homo sapiens	62-89
6853505-5	1983	The availability of octanoate as a specific substrate for the diglyceride acyltransferase reaction in cultured hepatocytes enables the measurement of this activity in situ under conditions of overall triglyceride synthesis.	Triglycerides	200-212	diacylglycerol O-acyltransferase 1	Homo sapiens	62-89
33945525-8	2021	Nephrocyte knockdown of diglyceride acyltransferase 1 (DGAT1), overexpression of adipose triglyceride lipase (ATGL), and epistasis tests together reveal that fatty acid flux through the lipid droplet triglyceride compartment protects the ER, mitochondria, and endocytosis of renal cells.	Fatty Acids	158-168	diacylglycerol O-acyltransferase 1	Homo sapiens	24-53
33945525-8	2021	Nephrocyte knockdown of diglyceride acyltransferase 1 (DGAT1), overexpression of adipose triglyceride lipase (ATGL), and epistasis tests together reveal that fatty acid flux through the lipid droplet triglyceride compartment protects the ER, mitochondria, and endocytosis of renal cells.	Fatty Acids	158-168	diacylglycerol O-acyltransferase 1	Homo sapiens	55-60
33465519-2	2021	The rate-limiting step in triglyceride synthesis is catalyzed by diacylglycerol acyltransferases (DGAT).	Triglycerides	26-38	diacylglycerol O-acyltransferase 1	Homo sapiens	65-96
33465519-2	2021	The rate-limiting step in triglyceride synthesis is catalyzed by diacylglycerol acyltransferases (DGAT).	Triglycerides	26-38	diacylglycerol O-acyltransferase 1	Homo sapiens	98-102
33828577-5	2021	Specifically, mechanistic links between sucrose non-fermenting-1-related protein kinase 1 (SnRK1)-mediated trehalose 6-phosphate (T6P) sensing and its regulation by phosphorylation of WRI1 stability, diacylglycerol acyltransferase 1 (DGAT1) enzyme activity, and of 2-OG-mediated relief of inhibition of acetyl-CoA carboxylase (ACCase) activity by protein PII are exemplified in detail in this review.	Sucrose	40-47	diacylglycerol O-acyltransferase 1	Homo sapiens	200-232
33828577-5	2021	Specifically, mechanistic links between sucrose non-fermenting-1-related protein kinase 1 (SnRK1)-mediated trehalose 6-phosphate (T6P) sensing and its regulation by phosphorylation of WRI1 stability, diacylglycerol acyltransferase 1 (DGAT1) enzyme activity, and of 2-OG-mediated relief of inhibition of acetyl-CoA carboxylase (ACCase) activity by protein PII are exemplified in detail in this review.	Sucrose	40-47	diacylglycerol O-acyltransferase 1	Homo sapiens	234-239
33723275-10	2021	Gossypol decreased the mRNA levels of DGAT, GLUT, TTP, IL families and a number of previously reported genes.	Gossypol	0-8	diacylglycerol O-acyltransferase 1	Homo sapiens	38-42
33750350-6	2021	Then we testified the DGAT1 expression and function after sodium oleate treatment in AGS and MKN45 cell line.	osteum	58-71	diacylglycerol O-acyltransferase 1	Homo sapiens	22-27
33897098-5	2021	Transcript profiling indicated that predominant route to TAG synthesis and oil accumulation is via the Kennedy pathway and diacylglycerol acyltransferase (DGAT) activity.	Oils	75-78	diacylglycerol O-acyltransferase 1	Homo sapiens	123-153
33897098-5	2021	Transcript profiling indicated that predominant route to TAG synthesis and oil accumulation is via the Kennedy pathway and diacylglycerol acyltransferase (DGAT) activity.	Oils	75-78	diacylglycerol O-acyltransferase 1	Homo sapiens	155-159
33326472-9	2020	Pharmacological modulation of LD formation by inhibition of DGAT-1 with A922500 significantly inhibited SARS-CoV-2 replication as well as reduced production of mediators pro-inflammatory response.	(IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid	72-79	diacylglycerol O-acyltransferase 1	Homo sapiens	60-66
33219129-7	2021	Interestingly, ABHD5-dependent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or DGAT2, isoenzymes that re-esterify fatty acids in a process that consumes ATP.	Fatty Acids	144-155	diacylglycerol O-acyltransferase 1	Homo sapiens	100-105
33219129-7	2021	Interestingly, ABHD5-dependent suppression of mTORC1 was abrogated by pharmacological inhibition of DGAT1 or DGAT2, isoenzymes that re-esterify fatty acids in a process that consumes ATP.	Adenosine Triphosphate	183-186	diacylglycerol O-acyltransferase 1	Homo sapiens	100-105
32878484-1	2020	INTRODUCTION: DGAT and MGAT enzymes play an important role in triacylglycerol (TGA) biosynthesis.	Triglycerides	62-77	diacylglycerol O-acyltransferase 1	Homo sapiens	14-18
32878484-1	2020	INTRODUCTION: DGAT and MGAT enzymes play an important role in triacylglycerol (TGA) biosynthesis.	tga	79-82	diacylglycerol O-acyltransferase 1	Homo sapiens	14-18
32559414-3	2020	Here, we identify that GBM upregulates diacylglycerol-acyltransferase 1 (DGAT1) to store excess FAs into triglycerides and lipid droplets.	Fatty Acids	96-99	diacylglycerol O-acyltransferase 1	Homo sapiens	39-71
32559414-3	2020	Here, we identify that GBM upregulates diacylglycerol-acyltransferase 1 (DGAT1) to store excess FAs into triglycerides and lipid droplets.	Fatty Acids	96-99	diacylglycerol O-acyltransferase 1	Homo sapiens	73-78
32559414-3	2020	Here, we identify that GBM upregulates diacylglycerol-acyltransferase 1 (DGAT1) to store excess FAs into triglycerides and lipid droplets.	Triglycerides	105-118	diacylglycerol O-acyltransferase 1	Homo sapiens	39-71
32559414-3	2020	Here, we identify that GBM upregulates diacylglycerol-acyltransferase 1 (DGAT1) to store excess FAs into triglycerides and lipid droplets.	Triglycerides	105-118	diacylglycerol O-acyltransferase 1	Homo sapiens	73-78
32559414-4	2020	Inhibiting DGAT1 disrupted lipid homeostasis and resulted in excessive FAs moving into mitochondria for oxidation, leading to the generation of high levels of reactive oxygen species (ROS), mitochondrial damage, cytochrome c release, and apoptosis.	Reactive Oxygen Species	159-182	diacylglycerol O-acyltransferase 1	Homo sapiens	11-16
32559414-4	2020	Inhibiting DGAT1 disrupted lipid homeostasis and resulted in excessive FAs moving into mitochondria for oxidation, leading to the generation of high levels of reactive oxygen species (ROS), mitochondrial damage, cytochrome c release, and apoptosis.	Reactive Oxygen Species	184-187	diacylglycerol O-acyltransferase 1	Homo sapiens	11-16
32559414-5	2020	Adding N-acetyl-cysteine or inhibiting FA shuttling into mitochondria decreased ROS and cell death induced by DGAT1 inhibition.	Acetylcysteine	7-24	diacylglycerol O-acyltransferase 1	Homo sapiens	110-115
32559414-5	2020	Adding N-acetyl-cysteine or inhibiting FA shuttling into mitochondria decreased ROS and cell death induced by DGAT1 inhibition.	Reactive Oxygen Species	80-83	diacylglycerol O-acyltransferase 1	Homo sapiens	110-115
32620771-8	2020	Treatment with cPLA2-alpha inhibitor (CAY10650) or DGAT-1 inhibitor (A922500) suppressed lipid droplets formation and PGE2 secretion.	(IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid	69-76	diacylglycerol O-acyltransferase 1	Homo sapiens	51-57
32620771-8	2020	Treatment with cPLA2-alpha inhibitor (CAY10650) or DGAT-1 inhibitor (A922500) suppressed lipid droplets formation and PGE2 secretion.	Dinoprostone	118-122	diacylglycerol O-acyltransferase 1	Homo sapiens	51-57
32438640-7	2020	Interestingly, inhibition of TGF-beta2 signaling and diacylglycerol O-acyltransferase (DGAT), the last enzyme involved in triglyceride synthesis, led to a significant restoration of DC activity and anticancer immune response.	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	53-85
32438640-7	2020	Interestingly, inhibition of TGF-beta2 signaling and diacylglycerol O-acyltransferase (DGAT), the last enzyme involved in triglyceride synthesis, led to a significant restoration of DC activity and anticancer immune response.	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	87-91
32433610-1	2020	Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans1.	triacylglycerides	55-72	diacylglycerol O-acyltransferase 1	Homo sapiens	0-34
32433610-1	2020	Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans1.	triacylglycerides	55-72	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
32433610-5	2020	Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate.	oleoyl-coenzyme A	89-99	diacylglycerol O-acyltransferase 1	Homo sapiens	64-69
32433611-3	2020	Triacylglycerol synthesis is catalysed by acyl-CoA diacylglycerol acyltransferase (DGAT) enzymes2-4, the structures and catalytic mechanisms of which remain unknown.	Triglycerides	0-15	diacylglycerol O-acyltransferase 1	Homo sapiens	83-87
32433611-6	2020	A structure obtained with oleoyl-CoA substrate resolved at approximately 3.2 A shows that the CoA moiety binds DGAT1 on the cytosolic side and the acyl group lies deep within a hydrophobic channel, positioning the acyl-CoA thioester bond near an invariant catalytic histidine residue.	oleoyl-coenzyme A	26-36	diacylglycerol O-acyltransferase 1	Homo sapiens	111-116
32433611-6	2020	A structure obtained with oleoyl-CoA substrate resolved at approximately 3.2 A shows that the CoA moiety binds DGAT1 on the cytosolic side and the acyl group lies deep within a hydrophobic channel, positioning the acyl-CoA thioester bond near an invariant catalytic histidine residue.	Coenzyme A	33-36	diacylglycerol O-acyltransferase 1	Homo sapiens	111-116
32433611-6	2020	A structure obtained with oleoyl-CoA substrate resolved at approximately 3.2 A shows that the CoA moiety binds DGAT1 on the cytosolic side and the acyl group lies deep within a hydrophobic channel, positioning the acyl-CoA thioester bond near an invariant catalytic histidine residue.	Histidine	266-275	diacylglycerol O-acyltransferase 1	Homo sapiens	111-116
32433611-9	2020	Insights provided by the DGAT1 structures, together with mutagenesis and functional studies, provide the basis for a model of the catalysis of triacylglycerol synthesis by DGAT.	Triglycerides	143-158	diacylglycerol O-acyltransferase 1	Homo sapiens	25-30
32433611-9	2020	Insights provided by the DGAT1 structures, together with mutagenesis and functional studies, provide the basis for a model of the catalysis of triacylglycerol synthesis by DGAT.	Triglycerides	143-158	diacylglycerol O-acyltransferase 1	Homo sapiens	25-29
32213983-4	2020	Twenty percent of the VDR responsive genes were related to lipid metabolism, including MOGAT1, LPGAT1, AGPAT2, and DGAT1 (glycerolipid metabolism); CDS1, PCTP, and MAT1A (phospholipid metabolism); and FATP2, SLC6A12, and AQP3 (uptake of fatty acids, betaine, and glycerol, respectively).	glycerolipid	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	115-120
32213983-4	2020	Twenty percent of the VDR responsive genes were related to lipid metabolism, including MOGAT1, LPGAT1, AGPAT2, and DGAT1 (glycerolipid metabolism); CDS1, PCTP, and MAT1A (phospholipid metabolism); and FATP2, SLC6A12, and AQP3 (uptake of fatty acids, betaine, and glycerol, respectively).	Glycerol	122-130	diacylglycerol O-acyltransferase 1	Homo sapiens	115-120
32160926-7	2020	The Met/Cys-low group had increased mRNA expression of lipogenic genes in adipose tissue including DGAT1.	Cysteine	8-11	diacylglycerol O-acyltransferase 1	Homo sapiens	99-104
32160926-8	2020	When we excluded one participant with high fasting insulin at baseline, the Met/Cys-low group showed increased expression of ACAC, DGAT1, and tendencies for increased expression of FASN and SCD1 compared to the Met/Cys-high group.	Cysteine	80-83	diacylglycerol O-acyltransferase 1	Homo sapiens	131-136
32138658-1	2020	BACKGROUND: The diacylglycerol acyltransferases (DGAT) are a vital group of enzymes in catalyzing triacylglycerol biosynthesis.	Triglycerides	98-113	diacylglycerol O-acyltransferase 1	Homo sapiens	16-47
32138658-1	2020	BACKGROUND: The diacylglycerol acyltransferases (DGAT) are a vital group of enzymes in catalyzing triacylglycerol biosynthesis.	Triglycerides	98-113	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
31652233-12	2020	cg09565397 (p-value=1.59 10), located within DGAT1 in chromosome 8, encodes an enzyme involved in triacylglycerol synthesis and has been associated with body mass index.	Triglycerides	98-113	diacylglycerol O-acyltransferase 1	Homo sapiens	45-50
31937853-5	2020	The results showed that DGAT1 was dominant in human skeletal muscle cells utilizing fatty acids (FAs) derived from various sources, both exogenously supplied FA, de novo synthesised FA, or FA derived from lipolysis, to generate TAG, as well as being involved in de novo synthesis of TAG.	Fatty Acids	84-95	diacylglycerol O-acyltransferase 1	Homo sapiens	24-29
31937853-5	2020	The results showed that DGAT1 was dominant in human skeletal muscle cells utilizing fatty acids (FAs) derived from various sources, both exogenously supplied FA, de novo synthesised FA, or FA derived from lipolysis, to generate TAG, as well as being involved in de novo synthesis of TAG.	Fatty Acids	97-100	diacylglycerol O-acyltransferase 1	Homo sapiens	24-29
31937853-5	2020	The results showed that DGAT1 was dominant in human skeletal muscle cells utilizing fatty acids (FAs) derived from various sources, both exogenously supplied FA, de novo synthesised FA, or FA derived from lipolysis, to generate TAG, as well as being involved in de novo synthesis of TAG.	Triglycerides	228-231	diacylglycerol O-acyltransferase 1	Homo sapiens	24-29
31937853-5	2020	The results showed that DGAT1 was dominant in human skeletal muscle cells utilizing fatty acids (FAs) derived from various sources, both exogenously supplied FA, de novo synthesised FA, or FA derived from lipolysis, to generate TAG, as well as being involved in de novo synthesis of TAG.	Triglycerides	283-286	diacylglycerol O-acyltransferase 1	Homo sapiens	24-29
31937853-7	2020	Interestingly, DGAT activities were also important for regulating FA oxidation, indicating a key role in balancing FAs between storage in TAG and efficient utilization through oxidation.	Fatty Acids	115-118	diacylglycerol O-acyltransferase 1	Homo sapiens	15-19
31937853-7	2020	Interestingly, DGAT activities were also important for regulating FA oxidation, indicating a key role in balancing FAs between storage in TAG and efficient utilization through oxidation.	Triglycerides	138-141	diacylglycerol O-acyltransferase 1	Homo sapiens	15-19
31937853-8	2020	Finally, we observed that inhibition of DGAT enzymes could potentially alter glucose-FA interactions in skeletal muscle.	Glucose	77-84	diacylglycerol O-acyltransferase 1	Homo sapiens	40-44
31937853-9	2020	In summary, treatment with DGAT1 or DGAT2 specific inhibitors resulted in different responses on lipid metabolism in human myotubes, indicating that the two enzymes play distinct roles in TAG metabolism in skeletal muscle.	Triglycerides	188-191	diacylglycerol O-acyltransferase 1	Homo sapiens	27-32
30950565-0	2019	First-in-Human Pharmacokinetics and Safety Study of GSK3008356, a Selective DGAT1 Inhibitor, in Healthy Volunteers.	gsk3008356	52-62	diacylglycerol O-acyltransferase 1	Homo sapiens	76-81
30950565-1	2019	Diacylglycerol acyltransferase (DGAT) enzymes are involved in triglyceride (TG) biosynthesis.	Triglycerides	62-74	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
30950565-1	2019	Diacylglycerol acyltransferase (DGAT) enzymes are involved in triglyceride (TG) biosynthesis.	Triglycerides	62-74	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
30950565-1	2019	Diacylglycerol acyltransferase (DGAT) enzymes are involved in triglyceride (TG) biosynthesis.	Triglycerides	76-78	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
30950565-1	2019	Diacylglycerol acyltransferase (DGAT) enzymes are involved in triglyceride (TG) biosynthesis.	Triglycerides	76-78	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
30950565-2	2019	GSK3008356 is a potent and selective DGAT1 inhibitor that was administered orally in a 2-part study as double-blind, randomized, placebo-controlled single doses (SDs) and repeat doses (RDs) in healthy subjects to investigate its pharmacokinetics, pharmacodynamics, and safety/tolerability.	gsk3008356	0-10	diacylglycerol O-acyltransferase 1	Homo sapiens	37-42
31657789-3	2019	A crucial step for the formation of LDs is the catalytic activity of diacylglycerol acyltransferases (DGAT) in the final step of TG synthesis.	Triglycerides	129-131	diacylglycerol O-acyltransferase 1	Homo sapiens	69-100
31657789-3	2019	A crucial step for the formation of LDs is the catalytic activity of diacylglycerol acyltransferases (DGAT) in the final step of TG synthesis.	Triglycerides	129-131	diacylglycerol O-acyltransferase 1	Homo sapiens	102-106
30790345-0	2019	A population analysis of the DGAT1 inhibitor GSK3008356 and its effect on endogenous and meal-induced triglyceride turnover in healthy subjects.	gsk3008356	45-55	diacylglycerol O-acyltransferase 1	Homo sapiens	29-34
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	gsk3008356	0-10	diacylglycerol O-acyltransferase 1	Homo sapiens	60-92
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	gsk3008356	0-10	diacylglycerol O-acyltransferase 1	Homo sapiens	94-99
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	Triglycerides	144-156	diacylglycerol O-acyltransferase 1	Homo sapiens	60-92
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	Triglycerides	144-156	diacylglycerol O-acyltransferase 1	Homo sapiens	94-99
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	Triglycerides	158-160	diacylglycerol O-acyltransferase 1	Homo sapiens	60-92
30790345-2	2019	GSK3008356 is under development as a selective inhibitor of diacylglycerol acyltransferase 1 (DGAT1), a key enzyme involved in the formation of triglyceride (TG).	Triglycerides	158-160	diacylglycerol O-acyltransferase 1	Homo sapiens	94-99
31315900-1	2019	Dietary lipids are taken up as fatty acids (FAs) by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs).	Fatty Acids	31-42	diacylglycerol O-acyltransferase 1	Homo sapiens	127-131
31315900-1	2019	Dietary lipids are taken up as fatty acids (FAs) by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs).	Fatty Acids	44-47	diacylglycerol O-acyltransferase 1	Homo sapiens	127-131
31315900-1	2019	Dietary lipids are taken up as fatty acids (FAs) by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs).	Triglycerides	146-159	diacylglycerol O-acyltransferase 1	Homo sapiens	95-125
31315900-1	2019	Dietary lipids are taken up as fatty acids (FAs) by the intestinal epithelium and converted by diacylglycerol acyltransferase (DGAT) enzymes into triglycerides, which are packaged in chylomicrons or stored in cytoplasmic lipid droplets (LDs).	Triglycerides	146-159	diacylglycerol O-acyltransferase 1	Homo sapiens	127-131
31456800-3	2019	They also express elevated amounts of both isoforms of diacylglycerol acyl transferase (DGAT1 &amp; 2), enzymes required for the terminal step of triacylglycerol synthesis.	Triglycerides	146-161	diacylglycerol O-acyltransferase 1	Homo sapiens	88-93
31151997-7	2019	Our results revealed that specific pathways like trehalose-related glycogen metabolism and enzymes such as wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT) are mainly restricted within specific types of bacterial groups, which provides evolutionary insights into the understanding of their origins and functions.	Trehalose	49-58	diacylglycerol O-acyltransferase 1	Homo sapiens	170-174
31151997-7	2019	Our results revealed that specific pathways like trehalose-related glycogen metabolism and enzymes such as wax ester synthase/acyl-CoA:diacylglycerol acyltransferase (WS/DGAT) are mainly restricted within specific types of bacterial groups, which provides evolutionary insights into the understanding of their origins and functions.	Glycogen	67-75	diacylglycerol O-acyltransferase 1	Homo sapiens	170-174
31331203-3	2019	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme which is responsible for the synthesis of triglycerides from 1,2-diacylglycerol by catalyzing the acyl-CoA-dependent acylation.	Triglycerides	116-129	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
31331203-3	2019	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme which is responsible for the synthesis of triglycerides from 1,2-diacylglycerol by catalyzing the acyl-CoA-dependent acylation.	Triglycerides	116-129	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
31331203-3	2019	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme which is responsible for the synthesis of triglycerides from 1,2-diacylglycerol by catalyzing the acyl-CoA-dependent acylation.	1,2-diacylglycerol	135-153	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
31331203-3	2019	Diacylglycerol acyltransferase (DGAT; EC 2.3.1.20) is a microsomal enzyme which is responsible for the synthesis of triglycerides from 1,2-diacylglycerol by catalyzing the acyl-CoA-dependent acylation.	1,2-diacylglycerol	135-153	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
31331203-12	2019	Thirteen new DGAT1 inhibitors were designed from the lead compound DGAT011.	dgat011	67-74	diacylglycerol O-acyltransferase 1	Homo sapiens	13-18
31413796-1	2019	Diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor Pradigastat (1) was shown to be effective at decreasing postprandial triglyceride levels in a patient population with familial chylomicronemia syndrome (FCS).	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	0-34
31413796-1	2019	Diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor Pradigastat (1) was shown to be effective at decreasing postprandial triglyceride levels in a patient population with familial chylomicronemia syndrome (FCS).	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
30952592-2	2019	Through a highly collaborative and iterative library design, synthesis and testing, a benzimidazole lead was rapidly and systematically advanced to a highly potent, selective and bioavailable DGAT1 inhibitor with the potential for further development.	benzimidazole	86-99	diacylglycerol O-acyltransferase 1	Homo sapiens	192-197
31049804-0	2019	D-ribose increases triglyceride via upregulation of DGAT in the liver.	Ribose	0-8	diacylglycerol O-acyltransferase 1	Homo sapiens	52-56
31049804-0	2019	D-ribose increases triglyceride via upregulation of DGAT in the liver.	Triglycerides	19-31	diacylglycerol O-acyltransferase 1	Homo sapiens	52-56
30647103-6	2019	Whereas in PC-3 cells, palmitate induced apoptosis, which was prevented by pretreatment of PC-3 cells with FAs, and this protective effect required DGAT-1-mediated triacylglycerol synthesis.	Palmitates	23-32	diacylglycerol O-acyltransferase 1	Homo sapiens	148-154
30647103-6	2019	Whereas in PC-3 cells, palmitate induced apoptosis, which was prevented by pretreatment of PC-3 cells with FAs, and this protective effect required DGAT-1-mediated triacylglycerol synthesis.	Triglycerides	164-179	diacylglycerol O-acyltransferase 1	Homo sapiens	148-154
30899516-1	2019	We have developed a novel mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model to describe the time course of plasma triglyceride (TAG) after Oral Lipid Tolerance Test (OLTT) and the effects of AZD7687, an inhibitor of diacylglycerol acyltransferase 1 (DGAT1), in humans, rats, and mice.	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	224-256
30899516-1	2019	We have developed a novel mechanistic pharmacokinetic-pharmacodynamic (PK/PD) model to describe the time course of plasma triglyceride (TAG) after Oral Lipid Tolerance Test (OLTT) and the effects of AZD7687, an inhibitor of diacylglycerol acyltransferase 1 (DGAT1), in humans, rats, and mice.	Triglycerides	122-134	diacylglycerol O-acyltransferase 1	Homo sapiens	258-263
30578966-5	2019	In the mesenchymal model, the diacylglycerol acyltransferase (DGAT)-1 appears to be the major enzyme involved in TAG synthesis and inhibition of DGAT1, but not DGAT2, drastically reduces the incorporation of labeled palmitate into TAG.	Palmitates	216-225	diacylglycerol O-acyltransferase 1	Homo sapiens	30-69
30658160-7	2019	Calcitriol treatment increased mRNA expression of triglyceride synthesizing genes DGAT1 and DGAT2 and also lipolytic genes ATGL and CGI-58.	Calcitriol	0-10	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
30658160-7	2019	Calcitriol treatment increased mRNA expression of triglyceride synthesizing genes DGAT1 and DGAT2 and also lipolytic genes ATGL and CGI-58.	Triglycerides	50-62	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
30718413-0	2019	DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.	Vitamin A	15-22	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30718413-2	2019	Here we show that memory phenotype CD4+ T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis (EAE), a widely studied animal model of MS, expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme that catalyzes triglyceride synthesis and retinyl ester formation.	Triglycerides	299-311	diacylglycerol O-acyltransferase 1	Homo sapiens	215-220
30718413-2	2019	Here we show that memory phenotype CD4+ T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis (EAE), a widely studied animal model of MS, expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme that catalyzes triglyceride synthesis and retinyl ester formation.	Triglycerides	299-311	diacylglycerol O-acyltransferase 1	Homo sapiens	230-264
30718413-2	2019	Here we show that memory phenotype CD4+ T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis (EAE), a widely studied animal model of MS, expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme that catalyzes triglyceride synthesis and retinyl ester formation.	Retinyl ester	326-339	diacylglycerol O-acyltransferase 1	Homo sapiens	215-220
30718413-2	2019	Here we show that memory phenotype CD4+ T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitis (EAE), a widely studied animal model of MS, expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1), an enzyme that catalyzes triglyceride synthesis and retinyl ester formation.	Retinyl ester	326-339	diacylglycerol O-acyltransferase 1	Homo sapiens	230-264
30718413-4	2019	DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic acid, a cofactor for Treg generation.	Vitamin A	42-49	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30718413-4	2019	DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic acid, a cofactor for Treg generation.	Esters	35-40	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30718413-4	2019	DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic acid, a cofactor for Treg generation.	Tretinoin	89-102	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30718413-4	2019	DGAT1 acyltransferase activity sequesters retinol in ester form, preventing synthesis of retinoic acid, a cofactor for Treg generation.	treg	119-123	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30718413-5	2019	In cultures with T cell-depleted lymphoid tissues, retinol enhanced Treg induction from DGAT1-/- but not from WT T cells.	Vitamin A	51-58	diacylglycerol O-acyltransferase 1	Homo sapiens	88-93
30718413-5	2019	In cultures with T cell-depleted lymphoid tissues, retinol enhanced Treg induction from DGAT1-/- but not from WT T cells.	treg	68-72	diacylglycerol O-acyltransferase 1	Homo sapiens	88-93
30718413-7	2019	These results demonstrate that DGAT1 suppresses retinol-dependent Treg formation and suggest its potential as a therapeutic target for autoimmune inflammation.	Vitamin A	48-55	diacylglycerol O-acyltransferase 1	Homo sapiens	31-36
30095213-6	2018	Elevation in cellular lipid levels, including diacylglycerol (DAG) and phospholipid metabolites of DAG, was documented by lipid analysis in DGAT1 knockdown cells.	Diglycerides	62-65	diacylglycerol O-acyltransferase 1	Homo sapiens	140-145
30095213-5	2018	DGAT1 knockdown in Caco2-BBe cells modeled the deficits in apical trafficking, with loss of apical DPPIV and junctional occludin.	caco2	19-24	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30095213-5	2018	DGAT1 knockdown in Caco2-BBe cells modeled the deficits in apical trafficking, with loss of apical DPPIV and junctional occludin.	CHEMBL145735	25-28	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
30095213-6	2018	Elevation in cellular lipid levels, including diacylglycerol (DAG) and phospholipid metabolites of DAG, was documented by lipid analysis in DGAT1 knockdown cells.	Diglycerides	46-60	diacylglycerol O-acyltransferase 1	Homo sapiens	140-145
30095213-6	2018	Elevation in cellular lipid levels, including diacylglycerol (DAG) and phospholipid metabolites of DAG, was documented by lipid analysis in DGAT1 knockdown cells.	Phospholipids	71-83	diacylglycerol O-acyltransferase 1	Homo sapiens	140-145
30095213-6	2018	Elevation in cellular lipid levels, including diacylglycerol (DAG) and phospholipid metabolites of DAG, was documented by lipid analysis in DGAT1 knockdown cells.	Diglycerides	99-102	diacylglycerol O-acyltransferase 1	Homo sapiens	140-145
30077544-0	2018	Role of DGAT enzymes in triacylglycerol metabolism.	Triglycerides	24-39	diacylglycerol O-acyltransferase 1	Homo sapiens	8-12
30077544-6	2018	DGAT1 is proposed to have dual topology contributing to TAG synthesis on both sides of the ER membrane and esterifying only the pre-formed fatty acids.	Fatty Acids	139-150	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Esters	27-32	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Esters	101-106	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Diglycerides	117-131	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Esters	178-184	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Fatty Acids	191-202	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-3	2018	An expedient route for wax-ester biocatalysis may be facilitated by the action of enzymes termed wax ester synthases/diacylglycerol acyltransferases (WS/DGAT), which produce wax esters using fatty acids and alcohols as a precursor.	Ethanol	207-215	diacylglycerol O-acyltransferase 1	Homo sapiens	153-157
31559109-7	2018	This study demonstrates the efficacy of a structure-guided engineering effort towards a WS/DGAT variant with preference towards wax esters of desired lengths.	Esters	132-138	diacylglycerol O-acyltransferase 1	Homo sapiens	91-95
30018616-8	2018	We identified a role for the human enzyme involved in TG synthesis, diacylglycerol O-acyltransferase (DGAT1), in this phenomenon.	Triglycerides	54-56	diacylglycerol O-acyltransferase 1	Homo sapiens	102-107
29604290-1	2018	BACKGROUND &amp; AIMS: Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from diacylglycerol and acyl-CoA.	Triglycerides	304-319	diacylglycerol O-acyltransferase 1	Homo sapiens	233-265
29604290-1	2018	BACKGROUND &amp; AIMS: Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from diacylglycerol and acyl-CoA.	Diglycerides	233-247	diacylglycerol O-acyltransferase 1	Homo sapiens	267-272
29604290-1	2018	BACKGROUND &amp; AIMS: Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from diacylglycerol and acyl-CoA.	Acyl Coenzyme A	344-352	diacylglycerol O-acyltransferase 1	Homo sapiens	233-265
29604290-9	2018	In patient-derived fibroblasts and organoids, the mutations reduced expression of DGAT1 protein and altered triacylglycerol metabolism, resulting in decreased lipid droplet formation after oleic acid addition.	Triglycerides	108-123	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
29604290-9	2018	In patient-derived fibroblasts and organoids, the mutations reduced expression of DGAT1 protein and altered triacylglycerol metabolism, resulting in decreased lipid droplet formation after oleic acid addition.	Oleic Acid	189-199	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
29602042-9	2018	The analysis also suggested that 6th position could be substituted with the oxadiazolyl ring or analogous heterocyclic rings, where the 3rd position of such heterocyclic rings substituted with rigid hydrophobic substitute can improve DGAT1 activity.	oxadiazolyl	76-87	diacylglycerol O-acyltransferase 1	Homo sapiens	234-239
29602042-8	2018	The 3D-QSAR model suggested that the substitutions of the alkyl group at the oxadiazolyl ring at the 6th position of the pyrrolo-pyridazine ring is undesirable, on the contrary, substituted phenyl ring at 7th position is responsible for the improved DGAT1 inhibitory activity.	oxadiazolyl	77-88	diacylglycerol O-acyltransferase 1	Homo sapiens	250-255
29602042-8	2018	The 3D-QSAR model suggested that the substitutions of the alkyl group at the oxadiazolyl ring at the 6th position of the pyrrolo-pyridazine ring is undesirable, on the contrary, substituted phenyl ring at 7th position is responsible for the improved DGAT1 inhibitory activity.	Pyrrolopyridazine	121-139	diacylglycerol O-acyltransferase 1	Homo sapiens	250-255
29523747-2	2018	Here, a potential process involving the catalytic actions of long-chain acyl-CoA synthetase (LACS) and diacylglycerol acyltransferase (DGAT) is proposed for ALA enrichment in triacylglycerol (TAG).	alpha-Linolenic Acid	157-160	diacylglycerol O-acyltransferase 1	Homo sapiens	135-139
29523747-2	2018	Here, a potential process involving the catalytic actions of long-chain acyl-CoA synthetase (LACS) and diacylglycerol acyltransferase (DGAT) is proposed for ALA enrichment in triacylglycerol (TAG).	Triglycerides	175-190	diacylglycerol O-acyltransferase 1	Homo sapiens	135-139
29242171-7	2018	Lastly, we investigated microRNA expression predicted to target SCD1 and diacylglycerol O-acyltransferase 1 (DGAT1) by PA.	Palmitic Acid	119-121	diacylglycerol O-acyltransferase 1	Homo sapiens	73-107
29242171-7	2018	Lastly, we investigated microRNA expression predicted to target SCD1 and diacylglycerol O-acyltransferase 1 (DGAT1) by PA.	Palmitic Acid	119-121	diacylglycerol O-acyltransferase 1	Homo sapiens	109-114
29242171-8	2018	Collectively, the results suggest potential roles of SCD1 and DGAT1 in alleviating the toxicity of PA and maintaining lipid homeostasis for normal placentation.	Palmitic Acid	99-101	diacylglycerol O-acyltransferase 1	Homo sapiens	62-67
29563512-2	2018	The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid.	Triglycerides	17-19	diacylglycerol O-acyltransferase 1	Homo sapiens	46-76
29563512-2	2018	The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid.	Triglycerides	17-19	diacylglycerol O-acyltransferase 1	Homo sapiens	78-82
29563512-2	2018	The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid.	Diglycerides	46-60	diacylglycerol O-acyltransferase 1	Homo sapiens	78-82
29563512-2	2018	The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid.	Fatty Acids	127-137	diacylglycerol O-acyltransferase 1	Homo sapiens	46-76
29563512-2	2018	The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid.	Fatty Acids	127-137	diacylglycerol O-acyltransferase 1	Homo sapiens	78-82
28866046-7	2017	SREBP-1c, ACC, FASN, and MTP, CES3 and DGAT1 proteins increased significantly after 24h of formaldehyde treatment.	Formaldehyde	91-103	diacylglycerol O-acyltransferase 1	Homo sapiens	39-44
27855567-2	2017	Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients.	Triglycerides	123-136	diacylglycerol O-acyltransferase 1	Homo sapiens	37-69
27855567-2	2017	Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients.	Triglycerides	123-136	diacylglycerol O-acyltransferase 1	Homo sapiens	71-76
27855567-2	2017	Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients.	Triglycerides	138-140	diacylglycerol O-acyltransferase 1	Homo sapiens	37-69
27855567-2	2017	Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients.	Triglycerides	138-140	diacylglycerol O-acyltransferase 1	Homo sapiens	71-76
28802563-9	2017	RESULTS: We validated human Agpat1 and Dgat1 mRNAs, involved in triglyceride synthesis, as targets of MIR122.	Triglycerides	64-76	diacylglycerol O-acyltransferase 1	Homo sapiens	39-44
28994204-0	2017	Directed evolution of DGAT1 to increase triacylglycerol content.	Triglycerides	40-55	diacylglycerol O-acyltransferase 1	Homo sapiens	22-27
28751309-3	2017	Mutants deficient in genes of fat metabolism, such as fcsA, encoding a fatty acid activating enzyme, or dgat1 and dgat2, specifying proteins that synthesize triacylglycerol, strongly increase their chances to contribute to the spore fraction of the developing fruiting body, but lose the ability to produce storage fat efficiently.	Fatty Acids	71-81	diacylglycerol O-acyltransferase 1	Homo sapiens	104-109
28751309-3	2017	Mutants deficient in genes of fat metabolism, such as fcsA, encoding a fatty acid activating enzyme, or dgat1 and dgat2, specifying proteins that synthesize triacylglycerol, strongly increase their chances to contribute to the spore fraction of the developing fruiting body, but lose the ability to produce storage fat efficiently.	Triglycerides	157-172	diacylglycerol O-acyltransferase 1	Homo sapiens	104-109
28877685-13	2017	Interestingly, DGAT-1 is involved in the synthesis of triacylglycerol where as ABHD5 is a hydrolase and participates in the fatty acid oxidation process, yet inhibition of both enzymes similarly promotes prostate cancer cell death.	Triglycerides	54-69	diacylglycerol O-acyltransferase 1	Homo sapiens	15-21
28877685-13	2017	Interestingly, DGAT-1 is involved in the synthesis of triacylglycerol where as ABHD5 is a hydrolase and participates in the fatty acid oxidation process, yet inhibition of both enzymes similarly promotes prostate cancer cell death.	Fatty Acids	124-134	diacylglycerol O-acyltransferase 1	Homo sapiens	15-21
28768178-0	2017	Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.	Triglycerides	0-12	diacylglycerol O-acyltransferase 1	Homo sapiens	26-31
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	Sulfhydryl Compounds	60-65	diacylglycerol O-acyltransferase 1	Homo sapiens	171-176
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	ros	110-113	diacylglycerol O-acyltransferase 1	Homo sapiens	171-176
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	beta-lapachone	142-156	diacylglycerol O-acyltransferase 1	Homo sapiens	171-176
28697336-5	2017	The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated FAs into new, clustered LDs that are in close proximity to mitochondria and are lipolytically degraded.	Fatty Acids	98-101	diacylglycerol O-acyltransferase 1	Homo sapiens	16-48
28697336-5	2017	The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively channels autophagy-liberated FAs into new, clustered LDs that are in close proximity to mitochondria and are lipolytically degraded.	Fatty Acids	98-101	diacylglycerol O-acyltransferase 1	Homo sapiens	50-55
28373485-1	2017	Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans.	Triglycerides	67-79	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
28373485-1	2017	Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans.	Triglycerides	67-79	diacylglycerol O-acyltransferase 1	Homo sapiens	41-47
28373485-1	2017	Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans.	Triglycerides	81-83	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
28373485-1	2017	Acyl-CoA:diacylglycerol acyltransferase (DGAT)1 and DGAT2 catalyze triglyceride (TG) biosynthesis in humans.	Triglycerides	81-83	diacylglycerol O-acyltransferase 1	Homo sapiens	41-47
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Diglycerides	180-183	diacylglycerol O-acyltransferase 1	Homo sapiens	75-105
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Diglycerides	180-183	diacylglycerol O-acyltransferase 1	Homo sapiens	107-111
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Diglycerides	180-183	diacylglycerol O-acyltransferase 1	Homo sapiens	144-148
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	192-204	diacylglycerol O-acyltransferase 1	Homo sapiens	75-105
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	192-204	diacylglycerol O-acyltransferase 1	Homo sapiens	107-111
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	192-204	diacylglycerol O-acyltransferase 1	Homo sapiens	144-148
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	206-208	diacylglycerol O-acyltransferase 1	Homo sapiens	75-105
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	206-208	diacylglycerol O-acyltransferase 1	Homo sapiens	107-111
28328322-4	2017	Furthermore, microsomal membrane preparations typically contain endogenous diacylglycerol acyltransferase (DGAT) from the host cells, and these DGAT activities can further acylate DAG to form triglyceride (TG).	Triglycerides	206-208	diacylglycerol O-acyltransferase 1	Homo sapiens	144-148
27788579-2	2017	Diacylglycerol transferase 1 (DGAT-1), a triglyceride synthesis enzyme, is important for the HCV life cycle in vitro.	Triglycerides	41-53	diacylglycerol O-acyltransferase 1	Homo sapiens	30-36
27815220-3	2017	To investigate the role of lecithin:retinol acyltransferase (LRAT) and acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) in retinyl ester synthesis and lipid droplet dynamics, we modified LC-MS/MS procedures by including multiple reaction monitoring allowing unambiguous identification and quantification of all major retinyl ester species.	Retinyl ester	124-137	diacylglycerol O-acyltransferase 1	Homo sapiens	114-119
27815220-5	2017	Exogenous fatty acids are a major determinant in the retinyl ester species synthesized by activated HSCs and LX-2 cells, indicating that HSCs shift their retinyl ester synthesizing capacity from LRAT to DGAT1 during activation.	Fatty Acids	10-21	diacylglycerol O-acyltransferase 1	Homo sapiens	203-208
28806138-4	2017	In our recent study, we demonstrated that FAs released during MTORC1-regulated autophagy are selectively channeled by DGAT1 (diacylglycerol O-acyltransferase 1) into triacylglycerol (TAG)-rich LDs.	Fatty Acids	42-45	diacylglycerol O-acyltransferase 1	Homo sapiens	118-123
28806138-4	2017	In our recent study, we demonstrated that FAs released during MTORC1-regulated autophagy are selectively channeled by DGAT1 (diacylglycerol O-acyltransferase 1) into triacylglycerol (TAG)-rich LDs.	Fatty Acids	42-45	diacylglycerol O-acyltransferase 1	Homo sapiens	125-159
28806138-4	2017	In our recent study, we demonstrated that FAs released during MTORC1-regulated autophagy are selectively channeled by DGAT1 (diacylglycerol O-acyltransferase 1) into triacylglycerol (TAG)-rich LDs.	Triglycerides	166-181	diacylglycerol O-acyltransferase 1	Homo sapiens	118-123
28806138-4	2017	In our recent study, we demonstrated that FAs released during MTORC1-regulated autophagy are selectively channeled by DGAT1 (diacylglycerol O-acyltransferase 1) into triacylglycerol (TAG)-rich LDs.	Triglycerides	166-181	diacylglycerol O-acyltransferase 1	Homo sapiens	125-159
28806138-5	2017	These DGAT1-dependent LDs sequester FAs and prevent the accumulation of acylcarnitines, which otherwise directly disrupt mitochondrial integrity.	Fatty Acids	36-39	diacylglycerol O-acyltransferase 1	Homo sapiens	6-11
27654821-4	2017	This paper reviews two key enzymes that play their role in production of bio-oil: DGAT (acyl-CoA:diacylglycerol acyltransferase) and PDAT (phospholipid:diacylglycerol acyltransferase).	Oils	77-80	diacylglycerol O-acyltransferase 1	Homo sapiens	82-86
27654821-4	2017	This paper reviews two key enzymes that play their role in production of bio-oil: DGAT (acyl-CoA:diacylglycerol acyltransferase) and PDAT (phospholipid:diacylglycerol acyltransferase).	Oils	77-80	diacylglycerol O-acyltransferase 1	Homo sapiens	88-127
27654821-4	2017	This paper reviews two key enzymes that play their role in production of bio-oil: DGAT (acyl-CoA:diacylglycerol acyltransferase) and PDAT (phospholipid:diacylglycerol acyltransferase).	Phospholipids	139-151	diacylglycerol O-acyltransferase 1	Homo sapiens	88-127
27836993-5	2017	DGAT1 does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes.	Glycerol	69-77	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
27803313-6	2016	Dimethyl sulfoxide treatment altered the expression of genes involved in lipid (FAS, ACC1, ACC2, DGAT1, DGAT2, SCD) and glucose (PEPCK, G6Pase) metabolism as well as liver functionality (albumin, alpha-1-antitrypsin, AFP).	Dimethyl Sulfoxide	0-18	diacylglycerol O-acyltransferase 1	Homo sapiens	97-102
27531967-1	2016	Acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT)-2 is one of the two DGAT enzymes that catalyzes the synthesis of triacylglycerol, which is an important form of stored energy for eukaryotic organisms.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	45-49
27706370-1	2016	Since the first diacylglycerol acyltransferase (DGAT) gene was characterized in plants, a number of studies have focused on understanding the role of DGAT activity in plant triacylglycerol (TAG) biosynthesis.	Triglycerides	173-188	diacylglycerol O-acyltransferase 1	Homo sapiens	16-46
27706370-1	2016	Since the first diacylglycerol acyltransferase (DGAT) gene was characterized in plants, a number of studies have focused on understanding the role of DGAT activity in plant triacylglycerol (TAG) biosynthesis.	Triglycerides	173-188	diacylglycerol O-acyltransferase 1	Homo sapiens	48-52
27706370-1	2016	Since the first diacylglycerol acyltransferase (DGAT) gene was characterized in plants, a number of studies have focused on understanding the role of DGAT activity in plant triacylglycerol (TAG) biosynthesis.	Triglycerides	173-188	diacylglycerol O-acyltransferase 1	Homo sapiens	150-154
27546480-6	2016	Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin.	Quercetin	226-235	diacylglycerol O-acyltransferase 1	Homo sapiens	48-78
27546480-6	2016	Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin.	Quercetin	226-235	diacylglycerol O-acyltransferase 1	Homo sapiens	197-201
26961929-7	2016	The messenger RNA expression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with maternal plasma enrichment in DHA and EPA (P &lt; 0.05).	Docosahexaenoic Acids	168-171	diacylglycerol O-acyltransferase 1	Homo sapiens	64-98
26961929-7	2016	The messenger RNA expression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with maternal plasma enrichment in DHA and EPA (P &lt; 0.05).	Docosahexaenoic Acids	168-171	diacylglycerol O-acyltransferase 1	Homo sapiens	100-105
26961929-7	2016	The messenger RNA expression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with maternal plasma enrichment in DHA and EPA (P &lt; 0.05).	Eicosapentaenoic Acid	176-179	diacylglycerol O-acyltransferase 1	Homo sapiens	64-98
26961929-7	2016	The messenger RNA expression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negatively correlated with maternal plasma enrichment in DHA and EPA (P &lt; 0.05).	Eicosapentaenoic Acid	176-179	diacylglycerol O-acyltransferase 1	Homo sapiens	100-105
26804232-0	2016	Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.	Diamide	13-20	diacylglycerol O-acyltransferase 1	Homo sapiens	34-66
26804232-0	2016	Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.	Diamide	13-20	diacylglycerol O-acyltransferase 1	Homo sapiens	68-73
26804232-1	2016	Diamide compounds were identified as potent DGAT1 inhibitors in vitro, but their poor molecular properties resulted in low oral bioavailability, both systemically and to DGAT1 in the enterocytes of the small intestine, resulting in a lack of efficacy in vivo.	Diamide	0-7	diacylglycerol O-acyltransferase 1	Homo sapiens	44-49
26804232-1	2016	Diamide compounds were identified as potent DGAT1 inhibitors in vitro, but their poor molecular properties resulted in low oral bioavailability, both systemically and to DGAT1 in the enterocytes of the small intestine, resulting in a lack of efficacy in vivo.	Diamide	0-7	diacylglycerol O-acyltransferase 1	Homo sapiens	170-175
26493024-1	2016	Diacylglycerol acyltransferase-1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes.	Triglycerides	58-70	diacylglycerol O-acyltransferase 1	Homo sapiens	0-32
26493024-1	2016	Diacylglycerol acyltransferase-1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes.	Triglycerides	58-70	diacylglycerol O-acyltransferase 1	Homo sapiens	34-39
26493024-1	2016	Diacylglycerol acyltransferase-1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes.	Triglycerides	72-74	diacylglycerol O-acyltransferase 1	Homo sapiens	0-32
26493024-1	2016	Diacylglycerol acyltransferase-1 (DGAT1), a key enzyme in triglyceride (TG) biogenesis, is highly associated with metabolic abnormalities, such as obesity and type 2 diabetes.	Triglycerides	72-74	diacylglycerol O-acyltransferase 1	Homo sapiens	34-39
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Hydrogen	112-120	diacylglycerol O-acyltransferase 1	Homo sapiens	26-31
26634958-4	2015	During the MD simulation, ArgP1 in a substrate accessed thrombin"s substrate-binding pocket and formed specific hydrogen bonds (H-bonds) with Asp189 in thrombin, while the catalytic serine of thrombin was still away from the substrate"s active site.	Serine	182-188	diacylglycerol O-acyltransferase 1	Homo sapiens	26-31
26634958-6	2015	Furthermore, in the earlier stage of ArgP1 access to the pocket, we observed that ArgP1 was spatially separated from Asp189 by two water molecules in the pocket.	Water	131-136	diacylglycerol O-acyltransferase 1	Homo sapiens	37-42
26634958-6	2015	Furthermore, in the earlier stage of ArgP1 access to the pocket, we observed that ArgP1 was spatially separated from Asp189 by two water molecules in the pocket.	Water	131-136	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
26228353-1	2015	Synthesis of neutral lipids such as triacylglycerols (TAG) and wax esters (WE) is catalyzed in bacteria by wax ester synthase/diacylglycerol acyltransferase enzymes (WS/DGAT).	Triglycerides	36-52	diacylglycerol O-acyltransferase 1	Homo sapiens	169-173
26228353-1	2015	Synthesis of neutral lipids such as triacylglycerols (TAG) and wax esters (WE) is catalyzed in bacteria by wax ester synthase/diacylglycerol acyltransferase enzymes (WS/DGAT).	wax esters	63-73	diacylglycerol O-acyltransferase 1	Homo sapiens	169-173
26246845-1	2015	BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis.	Fatty Acids	88-98	diacylglycerol O-acyltransferase 1	Homo sapiens	47-52
26246845-1	2015	BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis.	diacylglyceride	107-122	diacylglycerol O-acyltransferase 1	Homo sapiens	47-52
26246845-1	2015	BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis.	Triglycerides	130-142	diacylglycerol O-acyltransferase 1	Homo sapiens	47-52
26246845-1	2015	BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis.	Triglycerides	144-146	diacylglycerol O-acyltransferase 1	Homo sapiens	47-52
26246845-2	2015	DGAT1 plays a key role in the repackaging of dietary TG into circulating TG rich chylomicrons.	Triglycerides	53-55	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
26246845-2	2015	DGAT1 plays a key role in the repackaging of dietary TG into circulating TG rich chylomicrons.	Triglycerides	73-75	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
26246845-5	2015	METHODS: Twenty individual phytochemicals and an internal proprietary botanical extract library were screened with a primary cell-free DGAT1 enzyme assay that contained dioleoyl glycerol and palmitoleoyl Coenzyme A as substrates plus human intestinal microsomes as the DGAT1 enzyme source.	diolein	169-186	diacylglycerol O-acyltransferase 1	Homo sapiens	135-140
26246845-7	2015	The cellular DGAT1 assay comprised the analysis of (14)C labeled TG synthesis in cells incubated with (14)C-glycerol and 0.3 mM oleic acid.	Triglycerides	65-67	diacylglycerol O-acyltransferase 1	Homo sapiens	13-18
26246845-7	2015	The cellular DGAT1 assay comprised the analysis of (14)C labeled TG synthesis in cells incubated with (14)C-glycerol and 0.3 mM oleic acid.	14)c-glycerol	103-116	diacylglycerol O-acyltransferase 1	Homo sapiens	13-18
26246845-7	2015	The cellular DGAT1 assay comprised the analysis of (14)C labeled TG synthesis in cells incubated with (14)C-glycerol and 0.3 mM oleic acid.	Oleic Acid	128-138	diacylglycerol O-acyltransferase 1	Homo sapiens	13-18
26246845-11	2015	RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro.	phenolic acid	9-23	diacylglycerol O-acyltransferase 1	Homo sapiens	124-129
26246845-11	2015	RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro.	Gallic Acid	31-42	diacylglycerol O-acyltransferase 1	Homo sapiens	124-129
26246845-11	2015	RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro.	Polyphenols	48-59	diacylglycerol O-acyltransferase 1	Homo sapiens	124-129
26246845-11	2015	RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro.	cyanidin	67-75	diacylglycerol O-acyltransferase 1	Homo sapiens	124-129
26246845-14	2015	Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model.	Proanthocyanidins	108-125	diacylglycerol O-acyltransferase 1	Homo sapiens	219-224
26246845-14	2015	Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model.	Catechin	127-136	diacylglycerol O-acyltransferase 1	Homo sapiens	219-224
26246845-14	2015	Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model.	Anthocyanins	138-150	diacylglycerol O-acyltransferase 1	Homo sapiens	219-224
27144101-4	2016	These findings include a decrease in total GPAT and GPAT1 as a function of adipocyte size in both omental and subcutaneous adipose tissue and a strong, positive correlations between ACS, GPAT, and DGAT activities for both sexes and depots and between these storage factors and palmitate storage rates into TAG.	Palmitates	277-286	diacylglycerol O-acyltransferase 1	Homo sapiens	197-201
25745068-10	2015	DGAT1 and 2 knock-down with specific small interfering (si)-RNA completely abrogated the steatogenic effect of tetracycline in HepG2 cells.	Tetracycline	111-123	diacylglycerol O-acyltransferase 1	Homo sapiens	0-11
25792450-6	2015	However, inhibition of DGAT2 augmented fatty acid oxidation, whereas inhibition of DGAT1 increased triacylglycerol secretion, suggesting preferential channeling of separate DGAT-derived triacylglycerol pools to distinct metabolic pathways.	Fatty Acids	39-49	diacylglycerol O-acyltransferase 1	Homo sapiens	23-27
25792450-6	2015	However, inhibition of DGAT2 augmented fatty acid oxidation, whereas inhibition of DGAT1 increased triacylglycerol secretion, suggesting preferential channeling of separate DGAT-derived triacylglycerol pools to distinct metabolic pathways.	Triglycerides	99-114	diacylglycerol O-acyltransferase 1	Homo sapiens	83-88
25792450-6	2015	However, inhibition of DGAT2 augmented fatty acid oxidation, whereas inhibition of DGAT1 increased triacylglycerol secretion, suggesting preferential channeling of separate DGAT-derived triacylglycerol pools to distinct metabolic pathways.	Triglycerides	186-201	diacylglycerol O-acyltransferase 1	Homo sapiens	83-88
25792450-10	2015	CONCLUSIONS: Our data suggest that DGAT1 and DGAT2 can compensate for each other to synthesize triacylglycerol, but triacylglycerol synthesized by DGAT1 is preferentially channeled to oxidation, whereas DGAT2 synthesizes triacylglycerol destined for very low-density lipoprotein assembly.	Triglycerides	95-110	diacylglycerol O-acyltransferase 1	Homo sapiens	35-40
25792450-10	2015	CONCLUSIONS: Our data suggest that DGAT1 and DGAT2 can compensate for each other to synthesize triacylglycerol, but triacylglycerol synthesized by DGAT1 is preferentially channeled to oxidation, whereas DGAT2 synthesizes triacylglycerol destined for very low-density lipoprotein assembly.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	147-152
25792450-10	2015	CONCLUSIONS: Our data suggest that DGAT1 and DGAT2 can compensate for each other to synthesize triacylglycerol, but triacylglycerol synthesized by DGAT1 is preferentially channeled to oxidation, whereas DGAT2 synthesizes triacylglycerol destined for very low-density lipoprotein assembly.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	147-152
25740267-0	2015	Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.	Rosuvastatin Calcium	72-84	diacylglycerol O-acyltransferase 1	Homo sapiens	110-116
25740267-0	2015	Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor.	pradigastat	89-100	diacylglycerol O-acyltransferase 1	Homo sapiens	110-116
25997070-1	2015	The acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2 catalyze the final step in triglycerides biosynthesis.	Triglycerides	102-115	diacylglycerol O-acyltransferase 1	Homo sapiens	4-43
25997070-1	2015	The acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2 catalyze the final step in triglycerides biosynthesis.	Triglycerides	102-115	diacylglycerol O-acyltransferase 1	Homo sapiens	45-49
25997070-1	2015	The acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2 catalyze the final step in triglycerides biosynthesis.	Triglycerides	102-115	diacylglycerol O-acyltransferase 1	Homo sapiens	59-64
25997070-2	2015	This study examined the relationships of baseline phenotypes and the common polymorphisms in DGAT1 and DGAT2 with the lipid responses to niacin.Lipid responses in Chinese patients with dyslipidemia treated with the extended release (ER) niacin/laropiprant combination 1000/20 mg for 4 weeks and then 2000/40 mg for 8 weeks (n = 121, the primary study) or with ER niacin 1500 mg for at least 4 weeks (n = 68, the replication study) were analyzed according to genotypes of DGAT1 rs7003945 T&gt;C and DGAT2 rs3060 T&gt;C polymorphisms.Treatment with ER niacin improved all lipid parameters in both studies.	Niacin	137-143	diacylglycerol O-acyltransferase 1	Homo sapiens	93-98
25672855-0	2015	Phosphatidic acid phosphatase and diacylglycerol acyltransferase: potential targets for metabolic engineering of microorganism oil.	Oils	127-130	diacylglycerol O-acyltransferase 1	Homo sapiens	34-64
25672855-7	2015	In addition, PAP and DGAT are the conjunction points of the G3P pathway, the Kennedy pathway, and the CDP-diacylglycerol pathway (CDP-DAG pathway), and the mutual transformation between TAGs and phospholipids is discussed as well.	Phospholipids	195-208	diacylglycerol O-acyltransferase 1	Homo sapiens	21-25
25672855-8	2015	Given that both the Kennedy and CDP-diacylglycerol pathways are in metabolic interlock (MI) with the G3P pathway, it is suggested that, via metabolic engineering, TAG accumulation can be improved by the two pathways based on the pivotal function of PAP and DGAT.	Diglycerides	36-50	diacylglycerol O-acyltransferase 1	Homo sapiens	257-261
29148488-0	2015	Investigation of the conformational flexibility of DGAT1 peptides using tryptophan fluorescence.	Tryptophan	72-82	diacylglycerol O-acyltransferase 1	Homo sapiens	51-56
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	chylomicron triglyceride	71-95	diacylglycerol O-acyltransferase 1	Homo sapiens	14-46
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	chylomicron triglyceride	71-95	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	Triglycerides	97-99	diacylglycerol O-acyltransferase 1	Homo sapiens	14-46
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	Triglycerides	97-99	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	Triglycerides	148-150	diacylglycerol O-acyltransferase 1	Homo sapiens	14-46
25889044-2	2015	Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which mediates chylomicron triglyceride (TG) synthesis, is an attractive strategy to reduce TG levels in FCS.	Triglycerides	148-150	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
25889044-16	2015	CONCLUSION: The novel DGAT1 inhibitor pradigastat substantially reduces plasma TG levels in FCS patients, and may be a promising new treatment for this orphan disease.	Triglycerides	79-81	diacylglycerol O-acyltransferase 1	Homo sapiens	22-27
25152299-1	2014	Diacylglycerol acyltransferase 1 (DGAT1) is a microsomal membrane enzyme responsible for the final step in the synthesis of triacylglycerides.	triacylglycerides	124-141	diacylglycerol O-acyltransferase 1	Homo sapiens	0-32
25152299-1	2014	Diacylglycerol acyltransferase 1 (DGAT1) is a microsomal membrane enzyme responsible for the final step in the synthesis of triacylglycerides.	triacylglycerides	124-141	diacylglycerol O-acyltransferase 1	Homo sapiens	34-39
25152299-3	2014	The substrate binding sites of DGAT1 are predicted to be in its large luminal extramembranous loop and to include common motifs with acyl-CoA cholesterol acyltransferase enzymes and the diacylglycerol binding domain found in protein kinases.	Diglycerides	186-200	diacylglycerol O-acyltransferase 1	Homo sapiens	31-36
25152299-4	2014	In this study, synthetic peptides corresponding to the predicted binding sites of DGAT1 enzyme were examined using synchrotron radiation circular dichroism spectroscopy, fluorescence emission and adsorption onto lipid monolayers to determine their interactions with substrates associated with triacylglyceride synthesis (oleoyl-CoA and dioleoylglycerol).	triacylglyceride	293-309	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
25152299-4	2014	In this study, synthetic peptides corresponding to the predicted binding sites of DGAT1 enzyme were examined using synchrotron radiation circular dichroism spectroscopy, fluorescence emission and adsorption onto lipid monolayers to determine their interactions with substrates associated with triacylglyceride synthesis (oleoyl-CoA and dioleoylglycerol).	oleoyl-coenzyme A	321-331	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
25152299-4	2014	In this study, synthetic peptides corresponding to the predicted binding sites of DGAT1 enzyme were examined using synchrotron radiation circular dichroism spectroscopy, fluorescence emission and adsorption onto lipid monolayers to determine their interactions with substrates associated with triacylglyceride synthesis (oleoyl-CoA and dioleoylglycerol).	diolein	336-352	diacylglycerol O-acyltransferase 1	Homo sapiens	82-87
24954424-2	2014	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is responsible for catalyzing the final reaction in the glycerol phosphate pathway of triglycerol synthesis.	Glycerophosphates	103-121	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
24954424-2	2014	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is responsible for catalyzing the final reaction in the glycerol phosphate pathway of triglycerol synthesis.	Glycerophosphates	103-121	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
24954424-2	2014	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is responsible for catalyzing the final reaction in the glycerol phosphate pathway of triglycerol synthesis.	Triglycerol	133-144	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
24954424-2	2014	Acyl-CoA:diacylglycerol acyltransferase (DGAT) is responsible for catalyzing the final reaction in the glycerol phosphate pathway of triglycerol synthesis.	Triglycerol	133-144	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
25157099-3	2014	In contrast, failing human hearts have severely reduced DGAT1 expression associated with accumulation of DAGs and ceramides.	Ceramides	114-123	diacylglycerol O-acyltransferase 1	Homo sapiens	56-61
24899196-7	2014	Strikingly, after DGAT1 silencing, CLDN1 expression and HCV entry were also restored by low-dose palmitic acid treatment, indicating that the downregulation of CLDN1 was associated with altered fatty acid homeostasis in the absence of DGAT1.	Palmitic Acid	97-110	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
24899196-7	2014	Strikingly, after DGAT1 silencing, CLDN1 expression and HCV entry were also restored by low-dose palmitic acid treatment, indicating that the downregulation of CLDN1 was associated with altered fatty acid homeostasis in the absence of DGAT1.	Palmitic Acid	97-110	diacylglycerol O-acyltransferase 1	Homo sapiens	235-240
24934589-0	2014	A novel assay of DGAT activity based on high temperature GC/MS of triacylglycerol.	Triglycerides	66-81	diacylglycerol O-acyltransferase 1	Homo sapiens	17-21
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Acyl Coenzyme A	70-78	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Acyl Coenzyme A	70-78	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Triglycerides	105-120	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Triglycerides	105-120	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Fatty Acids	169-180	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Fatty Acids	169-180	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
24934589-1	2014	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG), a high-energy compound composed of three fatty acids esterified to a glycerol backbone.	Glycerol	6-14	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
24934589-6	2014	The GC/MS-based assay of DGAT activity was strongly correlated with the typical in vitro assay of the enzyme using [1-(14)C] acyl-CoA as an acyl donor.	[1-(14)c] acyl-coa	115-133	diacylglycerol O-acyltransferase 1	Homo sapiens	25-29
24820123-1	2014	Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by diacylglycerol acyltransferase (DGAT) in the endoplasmic reticulum (ER).	Triglycerides	0-15	diacylglycerol O-acyltransferase 1	Homo sapiens	102-132
24820123-1	2014	Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by diacylglycerol acyltransferase (DGAT) in the endoplasmic reticulum (ER).	Triglycerides	0-15	diacylglycerol O-acyltransferase 1	Homo sapiens	134-138
24820123-1	2014	Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by diacylglycerol acyltransferase (DGAT) in the endoplasmic reticulum (ER).	Triglycerides	17-19	diacylglycerol O-acyltransferase 1	Homo sapiens	102-132
24820123-1	2014	Triacylglycerol (TG) is the major form of stored energy in eukaryotic organisms and is synthesized by diacylglycerol acyltransferase (DGAT) in the endoplasmic reticulum (ER).	Triglycerides	17-19	diacylglycerol O-acyltransferase 1	Homo sapiens	134-138
24618302-0	2014	Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors.	quinaldic acid	19-44	diacylglycerol O-acyltransferase 1	Homo sapiens	55-60
24618302-1	2014	Herein we report the design and synthesis of a series of novel bicyclic DGAT1 inhibitors with a carboxylic acid moiety.	Carboxylic Acids	96-111	diacylglycerol O-acyltransferase 1	Homo sapiens	72-77
24618302-2	2014	The optimization of the initial lead compound 7 based on in vitro and in vivo activity led to the discovery of potent indoline and quinoline classes of DGAT1 inhibitors.	indoline	118-126	diacylglycerol O-acyltransferase 1	Homo sapiens	152-157
24618302-2	2014	The optimization of the initial lead compound 7 based on in vitro and in vivo activity led to the discovery of potent indoline and quinoline classes of DGAT1 inhibitors.	quinoline	131-140	diacylglycerol O-acyltransferase 1	Homo sapiens	152-157
24618302-3	2014	The structure-activity relationship studies of these novel series of bicyclic carboxylic acid derivatives as DGAT1 inhibitors are described.	bicyclic carboxylic acid	69-93	diacylglycerol O-acyltransferase 1	Homo sapiens	109-114
24118885-0	2014	Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial.	AZD7687	49-56	diacylglycerol O-acyltransferase 1	Homo sapiens	0-32
24118885-2	2014	This randomized, placebo-controlled, phase 1 study in 62 overweight or obese men explored the effects and tolerability of AZD7687, a reversible and selective DGAT1 inhibitor.	AZD7687	122-129	diacylglycerol O-acyltransferase 1	Homo sapiens	158-163
24118885-9	2014	CONCLUSIONS: Altered lipid handling and hormone secretion in the gut were demonstrated during 1-week treatment with the DGAT1 inhibitor AZD7687.	AZD7687	136-143	diacylglycerol O-acyltransferase 1	Homo sapiens	120-125
24562909-0	2014	Dictyostelium discoideum Dgat2 can substitute for the essential function of Dgat1 in triglyceride production but not in ether lipid synthesis.	Triglycerides	85-97	diacylglycerol O-acyltransferase 1	Homo sapiens	76-81
24562909-7	2014	In contrast, mammalian DGAT1 is more promiscuous regarding its substrates, producing diacylglycerol, retinyl esters, and waxes in addition to TAG.	Diglycerides	85-99	diacylglycerol O-acyltransferase 1	Homo sapiens	23-28
24562909-7	2014	In contrast, mammalian DGAT1 is more promiscuous regarding its substrates, producing diacylglycerol, retinyl esters, and waxes in addition to TAG.	retinyl esters	101-115	diacylglycerol O-acyltransferase 1	Homo sapiens	23-28
24562909-7	2014	In contrast, mammalian DGAT1 is more promiscuous regarding its substrates, producing diacylglycerol, retinyl esters, and waxes in addition to TAG.	Waxes	121-126	diacylglycerol O-acyltransferase 1	Homo sapiens	23-28
24562909-8	2014	The Dictyostelium Dgat1, however, produces TAG, wax esters, and, most interestingly, also neutral ether lipids, which represent a significant constituent of lipid droplets.	wax esters	48-58	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
24562909-8	2014	The Dictyostelium Dgat1, however, produces TAG, wax esters, and, most interestingly, also neutral ether lipids, which represent a significant constituent of lipid droplets.	ether lipids	98-110	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
24578031-0	2014	The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in Crambe seed oil.	erucic acid-rich	89-105	diacylglycerol O-acyltransferase 1	Homo sapiens	61-65
24578031-0	2014	The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in Crambe seed oil.	Triglycerides	106-122	diacylglycerol O-acyltransferase 1	Homo sapiens	61-65
24578031-0	2014	The utilization of the acyl-CoA and the involvement PDAT and DGAT in the biosynthesis of erucic acid-rich triacylglycerols in Crambe seed oil.	crambe seed oil	126-141	diacylglycerol O-acyltransferase 1	Homo sapiens	61-65
24578031-2	2014	This would suggest that C. abyssinica triacylglycerols are not formed by the action of the phospholipid:diacylglycerol acyltransferase (PDAT), but are rather the results of acyl-CoA:diacylglycerol acyltransferase (DGAT) activity.	Triglycerides	38-54	diacylglycerol O-acyltransferase 1	Homo sapiens	214-218
24578031-5	2014	This indicates that an expression of an isoform of DGAT with high specificity for erucoyl-CoA is induced at the onset of rapid erucic acid and oil accumulation in the C. abyssinica seeds.	erucyl-coenzyme A	82-93	diacylglycerol O-acyltransferase 1	Homo sapiens	51-55
24578031-5	2014	This indicates that an expression of an isoform of DGAT with high specificity for erucoyl-CoA is induced at the onset of rapid erucic acid and oil accumulation in the C. abyssinica seeds.	erucic acid	127-138	diacylglycerol O-acyltransferase 1	Homo sapiens	51-55
24578031-5	2014	This indicates that an expression of an isoform of DGAT with high specificity for erucoyl-CoA is induced at the onset of rapid erucic acid and oil accumulation in the C. abyssinica seeds.	Oils	143-146	diacylglycerol O-acyltransferase 1	Homo sapiens	51-55
24529140-5	2014	DGAT activity was measured by acylation of sn-l,2-diacylglycerol with [(14)C] oleoyl-CoA in microsomal fractions isolated from whole adipose tissue homogenates.	sn-l,2-diacylglycerol	43-64	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
24529140-5	2014	DGAT activity was measured by acylation of sn-l,2-diacylglycerol with [(14)C] oleoyl-CoA in microsomal fractions isolated from whole adipose tissue homogenates.	[(14)c] oleoyl-coa	70-88	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
24529140-11	2014	Plasma total, LDL and HDL TG levels were negatively associated with OM DGAT activity independent of total body fat mass (r = -0.39, p &lt; 0.05, r = -0.46, p &lt; 0.001 and r = -0.40, p &lt; 0.05 respectively).	Triglycerides	26-28	diacylglycerol O-acyltransferase 1	Homo sapiens	71-75
24262292-5	2014	RESULTS: Pre-existing maternal obesity and GDM are associated with decreased expression in genes involved in fatty acid uptake and intracellular transport (LPL, FATP2, FATP6, FABPpm and ASCL1), triacylglyceride (TAG) biosynthesis (MGAT1,7 MGAT2 and DGAT1), lipogenesis (FASN) and lipolysis (PNPLA2, HSL and MGLL).	Fatty Acids	109-119	diacylglycerol O-acyltransferase 1	Homo sapiens	249-254
23919406-2	2013	DGAT1 processes diacylglycerol to triglycerides in the final step of resynthesis for the absorption of fat across the intestine.	Diglycerides	16-30	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23919406-2	2013	DGAT1 processes diacylglycerol to triglycerides in the final step of resynthesis for the absorption of fat across the intestine.	Triglycerides	34-47	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23919406-4	2013	Proof of target engagement was achieved with the observation of reduced triglycerides upon treatment of humans with DGAT1 inhibitors; however, there were gastrointestinal adverse events such as nausea, diarrhea, and vomiting.	Triglycerides	72-85	diacylglycerol O-acyltransferase 1	Homo sapiens	116-121
24018969-5	2013	Furthermore, treatment with t10,c12 CLA led to increased mRNA expression and protein levels of lipogenic genes including SREBP1, ACC1, FASN, ELOVL6, GPAT1, and DGAT1, presenting potential mechanisms by which CLA may increase lipid deposition.	Linoleic Acids, Conjugated	36-39	diacylglycerol O-acyltransferase 1	Homo sapiens	160-165
23512750-9	2013	DGAT1 was elevated in CII&amp;III, and PLIN5 was elevated in CI compared to L. CONCLUSIONS: Severe obesity is associated with reduced muscle oxidative capacity and occurs concomitantly with elevated IMTG, ceramide and insulin resistance.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	22-25	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23512750-9	2013	DGAT1 was elevated in CII&amp;III, and PLIN5 was elevated in CI compared to L. CONCLUSIONS: Severe obesity is associated with reduced muscle oxidative capacity and occurs concomitantly with elevated IMTG, ceramide and insulin resistance.	Adenosine Monophosphate	26-29	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23871442-1	2013	DGAT-1 is an enzyme that catalyzes the final step in triglyceride synthesis.	Triglycerides	53-65	diacylglycerol O-acyltransferase 1	Homo sapiens	0-6
23871442-3	2013	The carboxylic acid-based DGAT-1 inhibitor 1 was advanced to clinical trials for the treatment of type 2 diabetes, despite of the low passive permeability of 1.	Carboxylic Acids	4-19	diacylglycerol O-acyltransferase 1	Homo sapiens	26-32
23810496-1	2013	A series of benzimidazole derivatives with a phenylcyclohexyl acetic acid group as DGAT-1 inhibitors was developed.	benzimidazole	12-25	diacylglycerol O-acyltransferase 1	Homo sapiens	83-89
23558010-2	2013	Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a member of the large family of membrane-bound O-acyltransferases, catalyzes the final step in triacylglycerol formation.	Triglycerides	146-161	diacylglycerol O-acyltransferase 1	Homo sapiens	0-41
23558010-2	2013	Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a member of the large family of membrane-bound O-acyltransferases, catalyzes the final step in triacylglycerol formation.	Triglycerides	146-161	diacylglycerol O-acyltransferase 1	Homo sapiens	43-48
23558010-3	2013	In the intestine, DGAT1 is one of the acyltransferases responsible for the reesterficiation of dietary TG.	Triglycerides	103-105	diacylglycerol O-acyltransferase 1	Homo sapiens	18-23
23558010-4	2013	Following a single dose of a selective pharmacological inhibitor of DGAT1, PF-04620110, a dose-dependent inhibition of TG and vitamin A absorption postprandially was demonstrated in rodents and human subjects.	PF-04620110	75-86	diacylglycerol O-acyltransferase 1	Homo sapiens	68-73
23558010-4	2013	Following a single dose of a selective pharmacological inhibitor of DGAT1, PF-04620110, a dose-dependent inhibition of TG and vitamin A absorption postprandially was demonstrated in rodents and human subjects.	Triglycerides	119-121	diacylglycerol O-acyltransferase 1	Homo sapiens	68-73
23558010-4	2013	Following a single dose of a selective pharmacological inhibitor of DGAT1, PF-04620110, a dose-dependent inhibition of TG and vitamin A absorption postprandially was demonstrated in rodents and human subjects.	Vitamin A	126-135	diacylglycerol O-acyltransferase 1	Homo sapiens	68-73
23558010-7	2013	DGAT1 inhibition causes an enrichment of polyunsaturated fatty acids within the TG class of lipids.	Fatty Acids, Unsaturated	41-68	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23558010-7	2013	DGAT1 inhibition causes an enrichment of polyunsaturated fatty acids within the TG class of lipids.	Triglycerides	80-82	diacylglycerol O-acyltransferase 1	Homo sapiens	0-5
23420847-1	2013	The triglyceride-synthesizing enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) plays a critical role in hepatitis C virus (HCV) infection by recruiting the HCV capsid protein core onto the surface of cellular lipid droplets (LDs).	Triglycerides	4-16	diacylglycerol O-acyltransferase 1	Homo sapiens	80-85
23489367-5	2013	This function is complemented, but not substituted for, by the ability of DGAT1 to rescue partial glycerides from complete hydrolysis.	Glycerides	98-108	diacylglycerol O-acyltransferase 1	Homo sapiens	74-79
23317570-0	2013	Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.	pyridine-carboxamide	23-43	diacylglycerol O-acyltransferase 1	Homo sapiens	54-60
23317570-1	2013	The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described.	Carboxylic Acids	65-80	diacylglycerol O-acyltransferase 1	Homo sapiens	121-127
23317570-1	2013	The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described.	pyridine-carboxamides	96-117	diacylglycerol O-acyltransferase 1	Homo sapiens	121-127
23242135-0	2013	Discovery of indolyl acrylamide derivatives as human diacylglycerol acyltransferase-2 selective inhibitors.	indolyl acrylamide	13-31	diacylglycerol O-acyltransferase 1	Homo sapiens	53-83
23242135-1	2013	A series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors.	indolyl acrylamide	12-30	diacylglycerol O-acyltransferase 1	Homo sapiens	72-102
23242135-1	2013	A series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors.	indolyl acrylamide	12-30	diacylglycerol O-acyltransferase 1	Homo sapiens	104-108
23242135-3	2013	Further evaluation against human DGAT-1 and DGAT-2 identified indolyl acrylamide analogues as selective inhibitors against human DGAT-2.	indolyl acrylamide	62-80	diacylglycerol O-acyltransferase 1	Homo sapiens	33-39
22950654-0	2013	Proof of mechanism for the DGAT1 inhibitor AZD7687: results from a first-time-in-human single-dose study.	AZD7687	43-50	diacylglycerol O-acyltransferase 1	Homo sapiens	27-32
22950654-1	2013	AIMS: Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which catalyses the final step in triacylglycerol (TAG) assembly, is suggested as a treatment for type 2 diabetes and obesity based on animal data indicating insulin sensitization and weight reduction.	Triglycerides	96-111	diacylglycerol O-acyltransferase 1	Homo sapiens	20-52
22950654-1	2013	AIMS: Inhibition of diacylglycerol acyltransferase 1 (DGAT1), which catalyses the final step in triacylglycerol (TAG) assembly, is suggested as a treatment for type 2 diabetes and obesity based on animal data indicating insulin sensitization and weight reduction.	Triglycerides	96-111	diacylglycerol O-acyltransferase 1	Homo sapiens	54-59
22950654-2	2013	This first-time-in-human single ascending dose study explored the safety, tolerability, pharmacokinetics and pharmacodynamics of the selective DGAT1 inhibitor AZD7687.	AZD7687	159-166	diacylglycerol O-acyltransferase 1	Homo sapiens	143-148
22950654-12	2013	CONCLUSIONS: The attenuating effect of AZD7687 on postprandial TAG excursion provides proof of mechanism with respect to gut DGAT1 inhibition.	AZD7687	39-46	diacylglycerol O-acyltransferase 1	Homo sapiens	125-130
23585481-1	2013	Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis.	Triglycerides	108-123	diacylglycerol O-acyltransferase 1	Homo sapiens	34-38
23585481-1	2013	Diacylglycerol acyltransferase 2 (DGAT2) is one of two distinct DGAT enzymes that catalyze the last step in triacylglycerol (TG) synthesis.	Triglycerides	125-127	diacylglycerol O-acyltransferase 1	Homo sapiens	34-38
23141914-0	2012	Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.	benzimidazole	31-44	diacylglycerol O-acyltransferase 1	Homo sapiens	60-90
23141914-2	2012	Among the newly synthesized compounds, furfurylamine containing benzimidazole carboxamide 10j showed the most potent DGAT inhibitory effect (IC(50)=4.4 muM) and inhibited triglyceride formation in HepG2 cells.	furfurylamine	39-52	diacylglycerol O-acyltransferase 1	Homo sapiens	117-121
23141914-2	2012	Among the newly synthesized compounds, furfurylamine containing benzimidazole carboxamide 10j showed the most potent DGAT inhibitory effect (IC(50)=4.4 muM) and inhibited triglyceride formation in HepG2 cells.	benzimidazole carboxamide 10j	64-93	diacylglycerol O-acyltransferase 1	Homo sapiens	117-121
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	Pyrazinamide	27-46	diacylglycerol O-acyltransferase 1	Homo sapiens	67-99
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	Pyrazinamide	27-46	diacylglycerol O-acyltransferase 1	Homo sapiens	101-106
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	dimethylpyrazinecarboxamide phenylcyclohexylacetic acid	140-195	diacylglycerol O-acyltransferase 1	Homo sapiens	67-99
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	dimethylpyrazinecarboxamide phenylcyclohexylacetic acid	140-195	diacylglycerol O-acyltransferase 1	Homo sapiens	101-106
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	AZD7687	197-204	diacylglycerol O-acyltransferase 1	Homo sapiens	67-99
23116186-0	2012	Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).	AZD7687	197-204	diacylglycerol O-acyltransferase 1	Homo sapiens	101-106
23116186-1	2012	A new series of pyrazinecarboxamide DGAT1 inhibitors was designed to address the need for a candidate drug with good potency, selectivity, and physical and DMPK properties combined with a low predicted dose in man.	Pyrazinamide	16-35	diacylglycerol O-acyltransferase 1	Homo sapiens	36-41
22705711-3	2012	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the final step in the sn-glycerol-3-phosphate pathway leading to TG.	alpha-glycerophosphoric acid	92-115	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
22705711-3	2012	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the final step in the sn-glycerol-3-phosphate pathway leading to TG.	alpha-glycerophosphoric acid	92-115	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
22705711-3	2012	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the final step in the sn-glycerol-3-phosphate pathway leading to TG.	Triglycerides	135-137	diacylglycerol O-acyltransferase 1	Homo sapiens	0-39
22705711-3	2012	Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes the final step in the sn-glycerol-3-phosphate pathway leading to TG.	Triglycerides	135-137	diacylglycerol O-acyltransferase 1	Homo sapiens	41-45
22748069-4	2012	By contrast, inhibition of DGAT1 affects equally the incorporation of glycerol and exogenous (preformed) oleate into cellular and secreted triacylglycerol (TAG).	Glycerol	70-78	diacylglycerol O-acyltransferase 1	Homo sapiens	27-32
22748069-4	2012	By contrast, inhibition of DGAT1 affects equally the incorporation of glycerol and exogenous (preformed) oleate into cellular and secreted triacylglycerol (TAG).	Triglycerides	139-154	diacylglycerol O-acyltransferase 1	Homo sapiens	27-32
22748069-5	2012	These data indicate that DGAT2 acts upstream of DGAT1, largely determines the rate of de novo synthesis of triglyceride, and uses nascent diacylglycerol and de novo synthesized fatty acids as substrates.	Triglycerides	107-119	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
22748069-5	2012	These data indicate that DGAT2 acts upstream of DGAT1, largely determines the rate of de novo synthesis of triglyceride, and uses nascent diacylglycerol and de novo synthesized fatty acids as substrates.	nascent diacylglycerol	130-152	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
22748069-5	2012	These data indicate that DGAT2 acts upstream of DGAT1, largely determines the rate of de novo synthesis of triglyceride, and uses nascent diacylglycerol and de novo synthesized fatty acids as substrates.	Fatty Acids	177-188	diacylglycerol O-acyltransferase 1	Homo sapiens	48-53
22748069-6	2012	By contrast, the data suggest that DGAT1 functions in the re-esterification of partial glycerides generated by intracellular lipolysis, using preformed (exogenous) fatty acids.	Glycerides	87-97	diacylglycerol O-acyltransferase 1	Homo sapiens	35-40
22748069-6	2012	By contrast, the data suggest that DGAT1 functions in the re-esterification of partial glycerides generated by intracellular lipolysis, using preformed (exogenous) fatty acids.	Fatty Acids	164-175	diacylglycerol O-acyltransferase 1	Homo sapiens	35-40
22683241-2	2012	Amino biphenyl carboxylic acids, exemplified by compound 4, are known potent inhibitors of hDGAT1.	amino biphenyl carboxylic acids	0-31	diacylglycerol O-acyltransferase 1	Homo sapiens	91-97
22683241-4	2012	We have synthesized and evaluated compounds containing 3-phenylisoxazole, 5-phenyloxazole, and 3-phenyl-1,2,4-oxadiazole biaryl units for their hDGAT1 inhibition.	3-Phenylisoxazole	55-72	diacylglycerol O-acyltransferase 1	Homo sapiens	144-150
22683241-4	2012	We have synthesized and evaluated compounds containing 3-phenylisoxazole, 5-phenyloxazole, and 3-phenyl-1,2,4-oxadiazole biaryl units for their hDGAT1 inhibition.	5-phenyl oxazole	74-89	diacylglycerol O-acyltransferase 1	Homo sapiens	144-150
22683241-4	2012	We have synthesized and evaluated compounds containing 3-phenylisoxazole, 5-phenyloxazole, and 3-phenyl-1,2,4-oxadiazole biaryl units for their hDGAT1 inhibition.	3-phenyl-1,2,4-oxadiazole biaryl	95-127	diacylglycerol O-acyltransferase 1	Homo sapiens	144-150
22683241-6	2012	Several compounds within the 3-phenylisoxazole series exhibited potent hDGAT1 inhibition when evaluated using an in vitro enzymatic assay.	3-Phenylisoxazole	29-46	diacylglycerol O-acyltransferase 1	Homo sapiens	71-77
22608962-0	2012	Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.	Oxadiazoles	55-65	diacylglycerol O-acyltransferase 1	Homo sapiens	66-72
22608962-1	2012	A novel series of DGAT-1 inhibitors was discovered from an oxadiazole amide high throughput screening (HTS) hit.	oxadiazole amide	59-75	diacylglycerol O-acyltransferase 1	Homo sapiens	18-24
22608962-2	2012	Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clinical in vivo efficacy that could be rationalised through a PK/PD relationship.	Carboxylic Acids	80-95	diacylglycerol O-acyltransferase 1	Homo sapiens	169-175
22608962-2	2012	Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clinical in vivo efficacy that could be rationalised through a PK/PD relationship.	AZD3988	130-137	diacylglycerol O-acyltransferase 1	Homo sapiens	169-175
22493088-0	2012	The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.	Glycerol	34-42	diacylglycerol O-acyltransferase 1	Homo sapiens	100-112
22493088-0	2012	The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2.	Oleic Acid	47-57	diacylglycerol O-acyltransferase 1	Homo sapiens	100-112
22493088-1	2012	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.	Triglycerides	66-78	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
22493088-1	2012	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.	Triglycerides	66-78	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
22493088-1	2012	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.	Triglycerides	80-82	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
22493088-1	2012	Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis.	Triglycerides	80-82	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
22493088-5	2012	Selective DGAT1 and DGAT2 inhibitors demonstrated that (13)C(3)-D(5)-glycerol-incorporated TG synthesis was mediated by DGAT2, not DGAT1.	Carbon-13	55-60	diacylglycerol O-acyltransferase 1	Homo sapiens	10-15
22493088-5	2012	Selective DGAT1 and DGAT2 inhibitors demonstrated that (13)C(3)-D(5)-glycerol-incorporated TG synthesis was mediated by DGAT2, not DGAT1.	(3)-d(5)-glycerol	60-77	diacylglycerol O-acyltransferase 1	Homo sapiens	10-15
22493088-5	2012	Selective DGAT1 and DGAT2 inhibitors demonstrated that (13)C(3)-D(5)-glycerol-incorporated TG synthesis was mediated by DGAT2, not DGAT1.	Triglycerides	91-93	diacylglycerol O-acyltransferase 1	Homo sapiens	10-15
22493088-6	2012	Conversely, (13)C(18)-oleoyl-incorporated TG synthesis was predominantly mediated by DGAT1.	Triglycerides	42-44	diacylglycerol O-acyltransferase 1	Homo sapiens	85-90
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	ammonium ferrous sulfate	158-161	diacylglycerol O-acyltransferase 1	Homo sapiens	32-37
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	Triglycerides	167-169	diacylglycerol O-acyltransferase 1	Homo sapiens	32-37
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	ammonium ferrous sulfate	231-234	diacylglycerol O-acyltransferase 1	Homo sapiens	32-37
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	ammonium ferrous sulfate	231-234	diacylglycerol O-acyltransferase 1	Homo sapiens	179-184
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	Glycerol	238-246	diacylglycerol O-acyltransferase 1	Homo sapiens	32-37
22493088-10	2012	Thus, our results indicate that DGAT1 and DGAT2 mediate distinct hepatic functions: DGAT2 is primarily responsible for incorporating endogenously synthesized FAs into TG, whereas DGAT1 plays a greater role in esterifying exogenous FAs to glycerol.	Glycerol	238-246	diacylglycerol O-acyltransferase 1	Homo sapiens	179-184
22405833-1	2012	A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered.	Thiadiazoles	47-58	diacylglycerol O-acyltransferase 1	Homo sapiens	17-22
21984835-3	2011	Core localizes to the surface of lipid droplets (LDs) in infected liver cells through a process dependent on host diacylglycerol acyltransferase 1 (DGAT1), an enzyme that synthesizes triglycerides in the endoplasmic reticulum.	Triglycerides	183-196	diacylglycerol O-acyltransferase 1	Homo sapiens	114-146
21984835-3	2011	Core localizes to the surface of lipid droplets (LDs) in infected liver cells through a process dependent on host diacylglycerol acyltransferase 1 (DGAT1), an enzyme that synthesizes triglycerides in the endoplasmic reticulum.	Triglycerides	183-196	diacylglycerol O-acyltransferase 1	Homo sapiens	148-153
21908190-0	2011	Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.	dioxino[2,3-d]pyrimidine	77-101	diacylglycerol O-acyltransferase 1	Homo sapiens	46-52
21908190-1	2011	A novel series of potent DGAT-1 inhibitors was developed originating from the lactam-based clinical candidate PF-04620110.	Lactams	78-84	diacylglycerol O-acyltransferase 1	Homo sapiens	25-31
21868220-2	2011	Biphenyl ureas, exemplified by compound 4, have been reported to be potent hDGAT1 inhibitors.	biphenyl ureas	0-14	diacylglycerol O-acyltransferase 1	Homo sapiens	75-81
21868220-3	2011	We have synthesized and evaluated 2-pyridyl and 3-pyridyl containing biaryl ureas as hDGAT1 inhibitors.	2-pyridyl and 3-pyridyl containing biaryl ureas	34-81	diacylglycerol O-acyltransferase 1	Homo sapiens	85-91
21653930-1	2011	Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes.	Triglycerides	0-16	diacylglycerol O-acyltransferase 1	Homo sapiens	121-159
21653930-1	2011	Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes.	Triglycerides	0-16	diacylglycerol O-acyltransferase 1	Homo sapiens	161-165
21653930-1	2011	Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes.	Triglycerides	18-20	diacylglycerol O-acyltransferase 1	Homo sapiens	121-159
21653930-1	2011	Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes.	Triglycerides	18-20	diacylglycerol O-acyltransferase 1	Homo sapiens	161-165
21653930-2	2011	In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA or diacylglycerol (DG) into TG.	Acyl Coenzyme A	108-122	diacylglycerol O-acyltransferase 1	Homo sapiens	9-13
21653930-2	2011	In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA or diacylglycerol (DG) into TG.	Diglycerides	126-140	diacylglycerol O-acyltransferase 1	Homo sapiens	9-13
21653930-2	2011	In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA or diacylglycerol (DG) into TG.	Triglycerides	151-153	diacylglycerol O-acyltransferase 1	Homo sapiens	9-13
21653930-4	2011	In the modified assay, radioactive fatty acyl CoA is replaced with fluorescent NBD-palmitoyl CoA, which is used as a substrate by DGAT with DG to produce NBD-TG.	radioactive fatty acyl coa	23-49	diacylglycerol O-acyltransferase 1	Homo sapiens	130-134
21653930-4	2011	In the modified assay, radioactive fatty acyl CoA is replaced with fluorescent NBD-palmitoyl CoA, which is used as a substrate by DGAT with DG to produce NBD-TG.	nbd-palmitoyl coa	79-96	diacylglycerol O-acyltransferase 1	Homo sapiens	130-134
21653930-4	2011	In the modified assay, radioactive fatty acyl CoA is replaced with fluorescent NBD-palmitoyl CoA, which is used as a substrate by DGAT with DG to produce NBD-TG.	nbd-tg	154-160	diacylglycerol O-acyltransferase 1	Homo sapiens	130-134
21369919-1	2011	Acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme plays a significant role in dietary triacylglycerol (TAG) absorption in the small intestine.	Triglycerides	97-112	diacylglycerol O-acyltransferase 1	Homo sapiens	48-52
21369919-3	2011	The aim of our study was to characterize the human intestinal DGAT enzyme by examining acyl-CoA specificity, temperature dependency, and selectivity for 1,2-diacylglycerol (DAG) or 1,3-DAG.	1,2-diacylglycerol	153-171	diacylglycerol O-acyltransferase 1	Homo sapiens	62-66
21369919-3	2011	The aim of our study was to characterize the human intestinal DGAT enzyme by examining acyl-CoA specificity, temperature dependency, and selectivity for 1,2-diacylglycerol (DAG) or 1,3-DAG.	1,2-diacylglycerol	173-176	diacylglycerol O-acyltransferase 1	Homo sapiens	62-66
21369919-3	2011	The aim of our study was to characterize the human intestinal DGAT enzyme by examining acyl-CoA specificity, temperature dependency, and selectivity for 1,2-diacylglycerol (DAG) or 1,3-DAG.	1,3-dag	181-188	diacylglycerol O-acyltransferase 1	Homo sapiens	62-66
21369919-5	2011	To elucidate the selectivity of human intestinal DGAT to 1,2-DAG or 1,3-DAG, we conducted acyl-coenzyme A:monoacylglycerol acyltransferase assays using 1- or 2-monoacylglycerol (MAG) as substrates.	1,2-dag	57-64	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
21369919-5	2011	To elucidate the selectivity of human intestinal DGAT to 1,2-DAG or 1,3-DAG, we conducted acyl-coenzyme A:monoacylglycerol acyltransferase assays using 1- or 2-monoacylglycerol (MAG) as substrates.	1,3-dag	68-75	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
21369919-5	2011	To elucidate the selectivity of human intestinal DGAT to 1,2-DAG or 1,3-DAG, we conducted acyl-coenzyme A:monoacylglycerol acyltransferase assays using 1- or 2-monoacylglycerol (MAG) as substrates.	1- or 2-monoacylglycerol	152-176	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
21369919-5	2011	To elucidate the selectivity of human intestinal DGAT to 1,2-DAG or 1,3-DAG, we conducted acyl-coenzyme A:monoacylglycerol acyltransferase assays using 1- or 2-monoacylglycerol (MAG) as substrates.	mag	178-181	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
21369919-7	2011	These findings suggest that human small intestinal DGAT, which is mainly encoded by DGAT1, utilizes 1,2-DAG as the substrate to form TAG.	1,2-dag	100-107	diacylglycerol O-acyltransferase 1	Homo sapiens	51-55
21369919-7	2011	These findings suggest that human small intestinal DGAT, which is mainly encoded by DGAT1, utilizes 1,2-DAG as the substrate to form TAG.	1,2-dag	100-107	diacylglycerol O-acyltransferase 1	Homo sapiens	84-89
22097091-8	2011	Some phytochemicals (vogelin B, vogelin C, isowightcone, abyssinin II, derrone) were the active principles as antibacterials, antifungals, antiplasmodials and inhibitors of enzyme borne diseases (PTP1B, HIV protease, DGAT).	derrone	71-78	diacylglycerol O-acyltransferase 1	Homo sapiens	217-221
20820848-4	2011	Inhibiting DGAT or CPT-1 by using, respectively, amidepsine or etomoxir increased DAG accumulation and sensitized myotubes to palmitate-induced insulin resistance.	amidepsine	49-59	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
20820848-4	2011	Inhibiting DGAT or CPT-1 by using, respectively, amidepsine or etomoxir increased DAG accumulation and sensitized myotubes to palmitate-induced insulin resistance.	etomoxir	63-71	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
20820848-4	2011	Inhibiting DGAT or CPT-1 by using, respectively, amidepsine or etomoxir increased DAG accumulation and sensitized myotubes to palmitate-induced insulin resistance.	dag	82-85	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
20820848-4	2011	Inhibiting DGAT or CPT-1 by using, respectively, amidepsine or etomoxir increased DAG accumulation and sensitized myotubes to palmitate-induced insulin resistance.	Palmitates	126-135	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
21317108-0	2011	DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.	Triglycerides	30-45	diacylglycerol O-acyltransferase 1	Homo sapiens	0-4
21317108-1	2011	The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	35-69
21317108-1	2011	The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	71-75
21317108-1	2011	The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.	Triglycerides	116-131	diacylglycerol O-acyltransferase 1	Homo sapiens	86-91
21317108-1	2011	The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.	Triglycerides	133-135	diacylglycerol O-acyltransferase 1	Homo sapiens	35-69
21317108-1	2011	The total contribution of the acyl CoA:diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.	Triglycerides	133-135	diacylglycerol O-acyltransferase 1	Homo sapiens	71-75
24900321-0	2011	Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.	PF-04620110	13-24	diacylglycerol O-acyltransferase 1	Homo sapiens	84-90
24900321-1	2011	Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides.	Triglycerides	109-122	diacylglycerol O-acyltransferase 1	Homo sapiens	0-41
24900321-1	2011	Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides.	Triglycerides	109-122	diacylglycerol O-acyltransferase 1	Homo sapiens	43-49
24900321-4	2011	Herein, we report the discovery and characterization of a potent and selective DGAT-1 inhibitor PF-04620110 (3).	PF-04620110	96-107	diacylglycerol O-acyltransferase 1	Homo sapiens	79-85
24900321-6	2011	In vivo DGAT-1 inhibition has been demonstrated through reduction of plasma triglyceride levels in rodents at doses of &gt;=0.1 mg/kg following a lipid challenge.	Triglycerides	76-88	diacylglycerol O-acyltransferase 1	Homo sapiens	8-14
20935628-2	2010	Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection.	Triglycerides	21-33	diacylglycerol O-acyltransferase 1	Homo sapiens	88-93
20833038-0	2010	Discovery of pyrrolopyridazines as novel DGAT1 inhibitors.	Pyrrolopyridazine	13-31	diacylglycerol O-acyltransferase 1	Homo sapiens	41-46
20509774-2	2010	Diacylglycerol acyltransferase (DGAT) catalyzes the final reaction of triacylglycerol synthesis.	Triglycerides	70-85	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
20509774-2	2010	Diacylglycerol acyltransferase (DGAT) catalyzes the final reaction of triacylglycerol synthesis.	Triglycerides	70-85	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
20509774-4	2010	Patent WO2009126624 proposes 69 new triazolopyridine compounds as DGAT1 inhibitors by Bristol-Myers Squibb.	wo2009126624	7-19	diacylglycerol O-acyltransferase 1	Homo sapiens	66-71
20509774-4	2010	Patent WO2009126624 proposes 69 new triazolopyridine compounds as DGAT1 inhibitors by Bristol-Myers Squibb.	triazolopyridine compounds	36-62	diacylglycerol O-acyltransferase 1	Homo sapiens	66-71
20509774-5	2010	The inhibitory activity of these triazolopyridine compounds was assessed in an enzyme assay using microsomal fractions prepared from human DGAT1-expressing insect cells.	CP-808844	33-49	diacylglycerol O-acyltransferase 1	Homo sapiens	139-144
20385122-7	2010	The potent and selective DGAT-1 inhibitor A-922500 (0.03, 0.3 and 3 mg/kg, p.o.	(IR,2R)-2-(4'-(3-phenyl-ureido)-biphenyl-4-carbonyl)cyclopentanecarboxylic acid	42-50	diacylglycerol O-acyltransferase 1	Homo sapiens	25-31
20385122-9	2010	At the highest dose of DGAT-1 inhibitor, the postprandial triglyceride response was abolished.	Triglycerides	58-70	diacylglycerol O-acyltransferase 1	Homo sapiens	23-29
20597032-3	2010	The progress of medicinal chemistry efforts has resulted in a new generation of DGAT1 inhibitors that have progressed into clinical development, with the leading compound LCQ-908 (Novartis AG) now in phase II clinical trials.	pradigastat	171-178	diacylglycerol O-acyltransferase 1	Homo sapiens	80-85
20493784-7	2010	Intracellularly, 2-monoacylglycerol and fatty acid are reconstituted to form triacylglycerol by the action of MGAT and DGAT.	1,3-dihydroxypropan-2-yl formate	17-35	diacylglycerol O-acyltransferase 1	Homo sapiens	119-123
20493784-7	2010	Intracellularly, 2-monoacylglycerol and fatty acid are reconstituted to form triacylglycerol by the action of MGAT and DGAT.	Fatty Acids	40-50	diacylglycerol O-acyltransferase 1	Homo sapiens	119-123
20493784-7	2010	Intracellularly, 2-monoacylglycerol and fatty acid are reconstituted to form triacylglycerol by the action of MGAT and DGAT.	Triglycerides	77-92	diacylglycerol O-acyltransferase 1	Homo sapiens	119-123
20167659-8	2010	HNF4A and DGAT1 expressions were analyzed in 80 human liver samples, and significant relationships were observed between HNF4A and DGAT1 mRNA levels (r(2)=0.50, P&lt;0.0001) and between DGAT1 mRNA levels and plasma triglyceride concentration (r(2)=0.09, P&lt;0.01).	Triglycerides	215-227	diacylglycerol O-acyltransferase 1	Homo sapiens	10-15
20167659-8	2010	HNF4A and DGAT1 expressions were analyzed in 80 human liver samples, and significant relationships were observed between HNF4A and DGAT1 mRNA levels (r(2)=0.50, P&lt;0.0001) and between DGAT1 mRNA levels and plasma triglyceride concentration (r(2)=0.09, P&lt;0.01).	Triglycerides	215-227	diacylglycerol O-acyltransferase 1	Homo sapiens	131-136
20167659-8	2010	HNF4A and DGAT1 expressions were analyzed in 80 human liver samples, and significant relationships were observed between HNF4A and DGAT1 mRNA levels (r(2)=0.50, P&lt;0.0001) and between DGAT1 mRNA levels and plasma triglyceride concentration (r(2)=0.09, P&lt;0.01).	Triglycerides	215-227	diacylglycerol O-acyltransferase 1	Homo sapiens	131-136
20460795-3	2010	A series of novel N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides 2 was designed from 1a, synthesized and evaluated for inhibitory activity against DGAT-1 enzyme.	n-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides	18-84	diacylglycerol O-acyltransferase 1	Homo sapiens	167-173
20195824-1	2010	Acyl-coenzyme A: diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes triglyceride synthesis in the glycerol phosphate pathway.	Triglycerides	78-90	diacylglycerol O-acyltransferase 1	Homo sapiens	17-47
20195824-1	2010	Acyl-coenzyme A: diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes triglyceride synthesis in the glycerol phosphate pathway.	Triglycerides	78-90	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
20195824-1	2010	Acyl-coenzyme A: diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes triglyceride synthesis in the glycerol phosphate pathway.	Glycerophosphates	108-126	diacylglycerol O-acyltransferase 1	Homo sapiens	17-47
20195824-1	2010	Acyl-coenzyme A: diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) catalyzes triglyceride synthesis in the glycerol phosphate pathway.	Glycerophosphates	108-126	diacylglycerol O-acyltransferase 1	Homo sapiens	49-53
20195824-4	2010	Five flavonoids were isolated from the ethanol extracts of licorice roots, using an in vitro DGAT inhibitory assay.	Flavonoids	5-15	diacylglycerol O-acyltransferase 1	Homo sapiens	93-97
20195824-4	2010	Five flavonoids were isolated from the ethanol extracts of licorice roots, using an in vitro DGAT inhibitory assay.	Ethanol	39-46	diacylglycerol O-acyltransferase 1	Homo sapiens	93-97
20195824-5	2010	One isoprenyl flavonoid showed most potential inhibition of DGAT on five flavonoids (1-5).	isoprenyl flavonoid	4-23	diacylglycerol O-acyltransferase 1	Homo sapiens	60-64
20195824-5	2010	One isoprenyl flavonoid showed most potential inhibition of DGAT on five flavonoids (1-5).	Flavonoids	73-83	diacylglycerol O-acyltransferase 1	Homo sapiens	60-64
20195824-8	2010	In addition, glabrol showed a noncompetitive type of inhibition against DGAT.	glabrol	13-20	diacylglycerol O-acyltransferase 1	Homo sapiens	72-76
20021283-3	2010	Diacylglycerol acyltransferase (DGAT) enzymes catalyze the final and only committed step in triglyceride biosynthesis and have thus been identified as potential therapeutic targets to combat human cardio-metabolic diseases.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
20021283-3	2010	Diacylglycerol acyltransferase (DGAT) enzymes catalyze the final and only committed step in triglyceride biosynthesis and have thus been identified as potential therapeutic targets to combat human cardio-metabolic diseases.	Triglycerides	92-104	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
19942946-4	2010	Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.	amidepsine	17-27	diacylglycerol O-acyltransferase 1	Homo sapiens	51-84
19942946-4	2010	Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.	amidepsine	17-27	diacylglycerol O-acyltransferase 1	Homo sapiens	86-91
19942946-4	2010	Non-glycosylated amidepsine J inhibited both human diacylglycerol acyltransferases 1 (DGAT1) and DGAT2 with the same IC(50) value of 40 muM, whereas glycosylated amidepsines F to I showed very weak inhibitory activity against DGAT1 and DGAT2.	amidepsine	17-27	diacylglycerol O-acyltransferase 1	Homo sapiens	226-231
19748893-12	2009	Expressing the ER enzyme DGAT1, which removes DG by converting it to triacylglycerol, attenuated perilipin 3 DG-induced ER recruitment.	Triglycerides	69-84	diacylglycerol O-acyltransferase 1	Homo sapiens	25-30
19682446-4	2009	The expression levels of LPL and DGAT1 proteins in the adipocytes treated with clozapine or rosiglitazone were determined by Western blot analysis.	Clozapine	79-88	diacylglycerol O-acyltransferase 1	Homo sapiens	33-38
19682446-4	2009	The expression levels of LPL and DGAT1 proteins in the adipocytes treated with clozapine or rosiglitazone were determined by Western blot analysis.	Rosiglitazone	92-105	diacylglycerol O-acyltransferase 1	Homo sapiens	33-38
19197254-1	2009	Diacylglycerol acyltransferase (DGAT) could be a rate limiting step in triglyceride (TG) synthesis as it is the final step in this pathway.	Triglycerides	71-83	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
19197254-1	2009	Diacylglycerol acyltransferase (DGAT) could be a rate limiting step in triglyceride (TG) synthesis as it is the final step in this pathway.	Triglycerides	71-83	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
19197254-1	2009	Diacylglycerol acyltransferase (DGAT) could be a rate limiting step in triglyceride (TG) synthesis as it is the final step in this pathway.	Triglycerides	85-87	diacylglycerol O-acyltransferase 1	Homo sapiens	0-30
19197254-1	2009	Diacylglycerol acyltransferase (DGAT) could be a rate limiting step in triglyceride (TG) synthesis as it is the final step in this pathway.	Triglycerides	85-87	diacylglycerol O-acyltransferase 1	Homo sapiens	32-36
18980578-1	2009	The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis.	Triglycerides	86-101	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
18980578-1	2009	The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis.	Triglycerides	86-101	diacylglycerol O-acyltransferase 1	Homo sapiens	17-56
18980578-1	2009	The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis.	Triglycerides	103-115	diacylglycerol O-acyltransferase 1	Homo sapiens	11-15
18980578-1	2009	The enzyme DGAT (acyl-CoA:diacylglycerol acyltransferase) catalyses the final step of triacylglycerol (triglyceride) synthesis.	Triglycerides	103-115	diacylglycerol O-acyltransferase 1	Homo sapiens	17-56
19132064-3	2009	Amidepsines and xanthohumol inhibited DGAT1 and DGAT2 with similar potency, whereas roselipins were found to inhibit DGAT2 selectively.	amidepsines	0-11	diacylglycerol O-acyltransferase 1	Homo sapiens	38-43
19132064-3	2009	Amidepsines and xanthohumol inhibited DGAT1 and DGAT2 with similar potency, whereas roselipins were found to inhibit DGAT2 selectively.	xanthohumol	16-27	diacylglycerol O-acyltransferase 1	Homo sapiens	38-43