PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
998518-0	1976	Renin and aldosterone suppression in the antihypertensive action of clonidine.	Clonidine	68-77	renin	Homo sapiens	0-5	
998518-1	1976	In 18 hypertensive patients receiving a constant (100 mEq/day) sodium diet, treatment with clonidine (0.3 mg/day for 5 days) decreased blood pressure in 11 patients with high and normal renin levels and 7 with low renin levels.	Clonidine	91-100	renin	Homo sapiens	186-191	
998518-1	1976	In 18 hypertensive patients receiving a constant (100 mEq/day) sodium diet, treatment with clonidine (0.3 mg/day for 5 days) decreased blood pressure in 11 patients with high and normal renin levels and 7 with low renin levels.	Clonidine	91-100	renin	Homo sapiens	214-219	
998518-5	1976	Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients.	Clonidine	34-43	renin	Homo sapiens	97-102	
998518-5	1976	Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients.	Clonidine	34-43	renin	Homo sapiens	155-160	
998518-5	1976	Thus, two mechanisms of action of clonidine are possible, one related to acute inhibition of the renin-angiotensin system in patients with high and normal renin levels and another that is independent of renin mechanisms and occurs in all hypertensive patients.	Clonidine	34-43	renin	Homo sapiens	155-160	
998518-11	1976	Thus, the antirenin effect of clonidine enhances its antihypertensive action not only by acutely ablating renin-angiotensin pressor mechanisms, but also by inhibiting aldosterone production and thereby minimizing longer-term reactive volume retention during treatment.	Clonidine	30-39	renin	Homo sapiens	14-19