PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9973252-2	1999	The mechanism underlying this down-regulation was studied in the rat liver cell line CWSV-1, where continuous GH suppressed the level of activated (tyrosine- phosphorylated) STAT5b to approximately 10-20% of the maximal GH pulse-induced STAT5b signal within 3 h. In contrast to the robust JAK2 kinase-dependent STAT5b activation loop that is established by a GH pulse, JAK2 kinase signaling to individual STAT5b molecules was found to be short lived in cells treated with GH continuously.	Tyrosine	148-156	signal transducer and activator of transcription 5B	Rattus norvegicus	174-180	
9973252-4	1999	Increased STAT5b DNA-binding activity was observed in cells treated with the proteasome inhibitor MG132, suggesting that at least one component of the GH receptor (GHR)-JAK2-STAT5b signaling pathway becomes labile in response to continuous GH treatment.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-103	signal transducer and activator of transcription 5B	Rattus norvegicus	10-16	
9973252-4	1999	Increased STAT5b DNA-binding activity was observed in cells treated with the proteasome inhibitor MG132, suggesting that at least one component of the GH receptor (GHR)-JAK2-STAT5b signaling pathway becomes labile in response to continuous GH treatment.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-103	growth hormone receptor	Rattus norvegicus	151-162	
9973252-4	1999	Increased STAT5b DNA-binding activity was observed in cells treated with the proteasome inhibitor MG132, suggesting that at least one component of the GH receptor (GHR)-JAK2-STAT5b signaling pathway becomes labile in response to continuous GH treatment.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-103	growth hormone receptor	Rattus norvegicus	164-167	
9973252-4	1999	Increased STAT5b DNA-binding activity was observed in cells treated with the proteasome inhibitor MG132, suggesting that at least one component of the GH receptor (GHR)-JAK2-STAT5b signaling pathway becomes labile in response to continuous GH treatment.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-103	Janus kinase 2	Rattus norvegicus	169-173	
9973252-4	1999	Increased STAT5b DNA-binding activity was observed in cells treated with the proteasome inhibitor MG132, suggesting that at least one component of the GH receptor (GHR)-JAK2-STAT5b signaling pathway becomes labile in response to continuous GH treatment.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-103	signal transducer and activator of transcription 5B	Rattus norvegicus	174-180	
9973252-5	1999	The phosphotyrosine phosphatase inhibitor pervanadate fully reversed the down-regulation of STAT5b DNA-binding activity in continuous GH-treated cells by a mechanism that involves both increased STAT5b activation and decreased STAT5b dephosphorylation.	pervanadate	42-53	signal transducer and activator of transcription 5B	Rattus norvegicus	92-98	
9973252-5	1999	The phosphotyrosine phosphatase inhibitor pervanadate fully reversed the down-regulation of STAT5b DNA-binding activity in continuous GH-treated cells by a mechanism that involves both increased STAT5b activation and decreased STAT5b dephosphorylation.	pervanadate	42-53	signal transducer and activator of transcription 5B	Rattus norvegicus	195-201	
9973252-5	1999	The phosphotyrosine phosphatase inhibitor pervanadate fully reversed the down-regulation of STAT5b DNA-binding activity in continuous GH-treated cells by a mechanism that involves both increased STAT5b activation and decreased STAT5b dephosphorylation.	pervanadate	42-53	signal transducer and activator of transcription 5B	Rattus norvegicus	195-201	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	pervanadate	165-176	signal transducer and activator of transcription 5B	Rattus norvegicus	94-100	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	pervanadate	165-176	growth hormone receptor	Rattus norvegicus	321-324	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	pervanadate	165-176	Janus kinase 2	Rattus norvegicus	325-329	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	Phosphotyrosine	204-219	signal transducer and activator of transcription 5B	Rattus norvegicus	94-100	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	Phosphotyrosine	204-219	growth hormone receptor	Rattus norvegicus	321-324	
9973252-6	1999	Moreover, the requirement for ongoing GH stimulation and active protein synthesis to maintain STAT5b activity in continuous GH-treated cells were both eliminated by pervanadate treatment, suggesting that phosphotyrosine dephosphorylation may be an obligatory first step in the internalization/degradation pathway for the GHR-JAK2 complex.	Phosphotyrosine	204-219	Janus kinase 2	Rattus norvegicus	325-329