PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9972388-1 1999 OBJECTIVE: To review published literature investigating the efficacy and safety of levodopa in the management of restless legs syndrome (RLS), with emphasis on the hemodialysis population. Levodopa 83-91 RLS1 Homo sapiens 137-140 9972388-4 1999 STUDY SELECTION AND DATA EXTRACTION: All identified human studies investigating the use of levodopa for the management of RLS in uremic and nonuremic patients were analyzed. Levodopa 91-99 RLS1 Homo sapiens 122-125 9972388-6 1999 Although the benefits of levodopa/(carbidopa/benserazide) in reducing the signs and symptoms of RLS are documented in nonuremic patients, evidence in patients with ESRD is less readily available. Levodopa 25-33 RLS1 Homo sapiens 96-99 9972388-8 1999 CONCLUSIONS: In general, the small amount of published literature supports the empirical use of levodopa/carbidopa as a safe and effective therapy to manage the distressing symptoms of RLS in a hemodialysis population. Levodopa 96-104 RLS1 Homo sapiens 185-188