PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9927185-3 1999 When treated with N-(phosphonacetyl)-L-aspartate (PALA), which inhibits pyrimidine nucleotide synthesis, leading to synthesis of damaged DNA from highly unbalanced dNTP pools, p53-null cells enter mitosis after they have completed DNA replication, but cells with wild-type p53 do not, revealing that p53 also mediates a checkpoint that monitors the quality of newly replicated DNA. Pyrimidine Nucleotides 72-93 tumor protein p53 Homo sapiens 176-179