PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9886842-4 1999 To this purpose, the effects of the LHRH agonist Zoladex (LHRH-A) on 1) the mitogenic action of IGF-I, 2) the tyrosine phosphorylation of type 1 IGF-I receptor (IGF-IR), 3) the concentration of IGF-IR, and 4) the secretion of IGF-binding protein-3 were studied. Tyrosine 110-118 gonadotropin releasing hormone 1 Homo sapiens 36-40 9886842-4 1999 To this purpose, the effects of the LHRH agonist Zoladex (LHRH-A) on 1) the mitogenic action of IGF-I, 2) the tyrosine phosphorylation of type 1 IGF-I receptor (IGF-IR), 3) the concentration of IGF-IR, and 4) the secretion of IGF-binding protein-3 were studied. Tyrosine 110-118 gonadotropin releasing hormone 1 Homo sapiens 58-62 9886842-5 1999 The results obtained show that in DU 145 cells, LHRH-A 1) counteracts the mitogenic action of IGF-I in a dose-dependent manner, 2) prevents the IGF-I-induced tyrosine phosphorylation of the IGF-IR, 3) reduces the concentration of IGF-IR without affecting its Kd value, and 4) does not affect the secretion of IGF-binding protein-3 in the conditioned medium from these cells. Tyrosine 158-166 gonadotropin releasing hormone 1 Homo sapiens 48-52